locus-tag	class	description
CLSA_c00010	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
CLSA_c00020	COG0592	DNA-directed DNA polymerase activity
CLSA_c00040	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
CLSA_c00060	COG0187	DNA topoisomerase II activity
CLSA_c00070	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CLSA_c00140	COG1827	regulation of RNA biosynthetic process
CLSA_c00230	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
CLSA_c00240	COG1074	ATP-dependent DNA helicase activity
CLSA_c00250	COG1376	ErfK ybiS ycfS ynhG family protein
CLSA_c00270	COG5002	protein histidine kinase activity
CLSA_c00290	COG0789	Transcriptional regulator
CLSA_c00290	COG4978	Transcriptional regulator
CLSA_c00320	COG0688	phosphatidylethanolamine metabolic process
CLSA_c00330	COG1309	transcriptional regulator
CLSA_c00350	COG0488	(ABC) transporter
CLSA_c00400	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
CLSA_c00410	COG1803	Methylglyoxal synthase
CLSA_c00440	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
CLSA_c00490	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CLSA_c00540	COG3949	Membrane
CLSA_c00550	COG1242	4 iron, 4 sulfur cluster binding
CLSA_c00560	COG2045	Belongs to the ComB family
CLSA_c00580	COG0745	RESPONSE REGULATOR receiver
CLSA_c00590	COG5002	protein histidine kinase activity
CLSA_c00640	COG1846	Transcriptional regulator
CLSA_c00670	COG2715	membrane protein required for spore maturation
CLSA_c00680	COG0700	Nucleoside recognition
CLSA_c00690	COG0006	proline dipeptidase activity
CLSA_c00730	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
CLSA_c00740	COG0084	hydrolase, TatD family'
CLSA_c00750	COG3583	domain protein
CLSA_c00750	COG3584	3D domain protein
CLSA_c00770	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
CLSA_c00830	COG1141	Ferredoxin
CLSA_c00860	COG1328	CTP reductase activity
CLSA_c00870	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CLSA_c00880	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
CLSA_c00890	COG0602	queuosine metabolic process
CLSA_c00910	COG2094	Belongs to the DNA glycosylase MPG family
CLSA_c00920	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
CLSA_c00940	COG0463	Glycosyl transferase, family 2
CLSA_c00950	COG0463	Glycosyl transferase, family 2
CLSA_c00960	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
CLSA_c00980	COG3681	Belongs to the UPF0597 family
CLSA_c00990	COG3328	transposase activity
CLSA_c01000	COG0017	Asparaginyl-tRNA synthetase
CLSA_c01030	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CLSA_c01040	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CLSA_c01050	COG2088	sporulation resulting in formation of a cellular spore
CLSA_c01060	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
CLSA_c01080	COG0745	RESPONSE REGULATOR receiver
CLSA_c01090	COG3850	Histidine kinase
CLSA_c01090	COG5002	protein histidine kinase activity
CLSA_c01100	COG0193	aminoacyl-tRNA hydrolase activity
CLSA_c01110	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
CLSA_c01160	COG2002	toxin-antitoxin pair type II binding
CLSA_c01170	COG2244	polysaccharide biosynthetic process
CLSA_c01180	COG3956	TIGRFAM MazG family protein
CLSA_c01200	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
CLSA_c01240	COG1098	S1 RNA binding domain
CLSA_c01350	COG2208	phosphoserine phosphatase activity
CLSA_c01360	COG0037	tRNA processing
CLSA_c01380	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CLSA_c01390	COG2759	Belongs to the formate--tetrahydrofolate ligase family
CLSA_c01400	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
CLSA_c01410	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CLSA_c01420	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CLSA_c01430	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
CLSA_c01470	COG0423	glycine-tRNA ligase activity
CLSA_c01480	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
CLSA_c01610	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
CLSA_c01620	COG3870	Protein conserved in bacteria
CLSA_c01630	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
CLSA_c01640	COG1774	PSP1 C-terminal conserved region
CLSA_c01670	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
CLSA_c01690	COG3880	PFAM UvrB UvrC protein
CLSA_c01710	COG0542	response to heat
CLSA_c01740	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
CLSA_c01750	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
CLSA_c01770	COG4956	integral membrane protein (PIN domain superfamily)
CLSA_c01780	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
CLSA_c01790	COG0442	prolyl-tRNA aminoacylation
CLSA_c01800	COG0215	cysteine-tRNA ligase activity
CLSA_c01820	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CLSA_c01860	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CLSA_c01870	COG0267	Belongs to the bacterial ribosomal protein bL33 family
CLSA_c01880	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CLSA_c01890	COG0250	Participates in transcription elongation, termination and antitermination
CLSA_c01900	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
CLSA_c01910	COG0081	regulation of translation
CLSA_c01940	COG0085	RNA polymerase activity
CLSA_c01950	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
CLSA_c01980	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CLSA_c01990	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
CLSA_c02000	COG0051	transcription antitermination factor activity, RNA binding
CLSA_c02010	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
CLSA_c02020	COG0088	Forms part of the polypeptide exit tunnel
CLSA_c02030	COG0089	rRNA binding
CLSA_c02040	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
CLSA_c02050	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
CLSA_c02060	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
CLSA_c02070	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
CLSA_c02080	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
CLSA_c02090	COG0255	Belongs to the universal ribosomal protein uL29 family
CLSA_c02100	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
CLSA_c02120	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
CLSA_c02130	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
CLSA_c02140	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
CLSA_c02160	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
CLSA_c02170	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
CLSA_c02180	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
CLSA_c02190	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
CLSA_c02200	COG1841	ribosomal large subunit assembly
CLSA_c02210	COG0200	Binds to the 23S rRNA
CLSA_c02220	COG0201	protein transport
CLSA_c02230	COG0563	adenylate kinase activity
CLSA_c02260	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
CLSA_c02270	COG0257	Belongs to the bacterial ribosomal protein bL36 family
CLSA_c02280	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
CLSA_c02290	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
CLSA_c02300	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
CLSA_c02310	COG0202	RNA polymerase activity
CLSA_c02320	COG0203	ribosomal protein L17
CLSA_c02330	COG1122	ATPase activity
CLSA_c02340	COG1122	ATPase activity
CLSA_c02350	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
CLSA_c02360	COG0101	tRNA pseudouridine synthase activity
CLSA_c02370	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
CLSA_c02380	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
CLSA_c02390	COG0860	N-Acetylmuramoyl-L-alanine amidase
CLSA_c02400	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
CLSA_c02420	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CLSA_c02460	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CLSA_c02470	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CLSA_c02480	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CLSA_c02500	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
CLSA_c02510	COG3773	Cell wall hydrolase
CLSA_c02530	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
CLSA_c02560	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
CLSA_c02570	COG0280	phosphate acetyltransferase
CLSA_c02590	COG1418	mRNA catabolic process
CLSA_c02600	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
CLSA_c02610	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
CLSA_c02610	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
CLSA_c02630	COG4496	protein, YerC YecD
CLSA_c02640	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CLSA_c02650	COG0071	Belongs to the small heat shock protein (HSP20) family
CLSA_c02670	COG0440	acetolactate synthase activity
CLSA_c02680	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CLSA_c02690	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
CLSA_c02700	COG0066	3-isopropylmalate dehydratase activity
CLSA_c02710	COG0473	3-isopropylmalate dehydrogenase activity
CLSA_c02730	COG0028	Belongs to the TPP enzyme family
CLSA_c02740	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
CLSA_c02810	COG1136	(ABC) transporter
CLSA_c02820	COG0577	efflux transmembrane transporter activity
CLSA_c02830	COG0626	cystathionine gamma-synthase activity
CLSA_c02840	COG0626	cystathionine gamma-synthase activity
CLSA_c02850	COG1846	Transcriptional regulator
CLSA_c02880	COG2801	Transposase and inactivated derivatives
CLSA_c02910	COG2801	Transposase and inactivated derivatives
CLSA_c03020	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CLSA_c03040	COG4152	abc transporter atp-binding protein
CLSA_c03070	COG1032	radical SAM domain protein
CLSA_c03150	COG0840	transmembrane signaling receptor activity
CLSA_c03160	COG0840	transmembrane signaling receptor activity
CLSA_c03170	COG0840	transmembrane signaling receptor activity
CLSA_c03190	COG2116	formate transmembrane transporter activity
CLSA_c03210	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
CLSA_c03250	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
CLSA_c03290	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
CLSA_c03310	COG0726	polysaccharide deacetylase
CLSA_c03330	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
CLSA_c03400	COG1136	(ABC) transporter
CLSA_c03400	COG0577	efflux transmembrane transporter activity
CLSA_c03410	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
CLSA_c03450	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
CLSA_c03470	COG2186	Transcriptional regulator
CLSA_c03480	COG2086	electron transfer activity
CLSA_c03490	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
CLSA_c03500	COG0277	FAD linked oxidase domain protein
CLSA_c03510	COG0653	protein targeting
CLSA_c03520	COG0662	Cupin 2, conserved barrel domain protein
CLSA_c03520	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
CLSA_c03550	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
CLSA_c03560	COG1024	Enoyl-CoA hydratase
CLSA_c03570	COG1960	acyl-CoA dehydrogenase activity
CLSA_c03580	COG2086	electron transfer activity
CLSA_c03600	COG1250	3-hydroxyacyl-CoA dehydrogenase
CLSA_c03630	COG1403	HNH endonuclease
CLSA_c03650	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
CLSA_c03660	COG0459	protein refolding
CLSA_c03680	COG0516	GMP reductase activity
CLSA_c03680	COG0517	IMP dehydrogenase activity
CLSA_c03710	COG0166	Belongs to the GPI family
CLSA_c03720	COG1671	Belongs to the UPF0178 family
CLSA_c03730	COG0745	RESPONSE REGULATOR receiver
CLSA_c03740	COG3850	Histidine kinase
CLSA_c03740	COG5002	protein histidine kinase activity
CLSA_c03790	COG0741	lytic transglycosylase activity
CLSA_c03800	COG1187	pseudouridine synthase activity
CLSA_c03820	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
CLSA_c03910	COG0622	Phosphoesterase
CLSA_c04110	COG0582	viral genome integration into host DNA
CLSA_c04170	COG1484	DNA-dependent DNA replication
CLSA_c04180	COG2002	toxin-antitoxin pair type II binding
CLSA_c04190	COG3617	BRO family, N-terminal domain
CLSA_c04250	COG0586	Pfam SNARE associated Golgi protein
CLSA_c04270	COG0861	Integral membrane protein TerC family
CLSA_c04430	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
CLSA_c04440	COG0732	type I restriction modification DNA specificity domain
CLSA_c04450	COG4974	Belongs to the 'phage' integrase family
CLSA_c04480	COG1192	Involved in chromosome partitioning
CLSA_c04500	COG3328	transposase activity
CLSA_c04540	COG0789	Transcriptional regulator
CLSA_c04540	COG4978	Transcriptional regulator
CLSA_c04600	COG3590	peptidase
CLSA_c04660	COG0312	modulator of DNA gyrase
CLSA_c04670	COG0312	modulator of DNA gyrase
CLSA_c04680	COG1368	sulfuric ester hydrolase activity
CLSA_c04730	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
CLSA_c04750	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CLSA_c04850	COG0840	transmembrane signaling receptor activity
CLSA_c04860	COG4466	Protein conserved in bacteria
CLSA_c04870	COG1388	LysM domain
CLSA_c04870	COG0791	NLP P60 protein
CLSA_c04890	COG0189	ligase activity
CLSA_c04890	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CLSA_c04900	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
CLSA_c04920	COG0482	sulfurtransferase activity
CLSA_c04950	COG0504	CTP synthase activity
CLSA_c04960	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
CLSA_c04970	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CLSA_c04980	COG0254	rRNA binding
CLSA_c05010	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
CLSA_c05030	COG0009	L-threonylcarbamoyladenylate synthase
CLSA_c05040	COG0698	ribose 5-phosphate isomerase
CLSA_c05050	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
CLSA_c05070	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
CLSA_c05080	COG0183	Belongs to the thiolase family
CLSA_c05090	COG0356	it plays a direct role in the translocation of protons across the membrane
CLSA_c05100	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CLSA_c05110	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
CLSA_c05130	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
CLSA_c05140	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
CLSA_c05150	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
CLSA_c05190	COG2385	sporulation resulting in formation of a cellular spore
CLSA_c05210	COG1609	Transcriptional regulator
CLSA_c05330	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
CLSA_c05350	COG1040	competence protein
CLSA_c05370	COG0653	protein targeting
CLSA_c05380	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
CLSA_c05430	COG5002	protein histidine kinase activity
CLSA_c05450	COG2183	response to ionizing radiation
CLSA_c05460	COG3949	Membrane
CLSA_c05470	COG1473	amidohydrolase
CLSA_c05490	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
CLSA_c05530	COG0494	nUDIX hydrolase
CLSA_c05540	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CLSA_c05570	COG4656	Part of a membrane complex involved in electron transport
CLSA_c05580	COG4658	electron transport chain
CLSA_c05590	COG4659	FMN binding
CLSA_c05600	COG4660	Part of a membrane complex involved in electron transport
CLSA_c05610	COG4657	Part of a membrane complex involved in electron transport
CLSA_c05620	COG1148	4fe-4S ferredoxin, iron-sulfur binding domain protein
CLSA_c05620	COG2878	Part of a membrane complex involved in electron transport
CLSA_c05690	COG2703	oxygen carrier activity
CLSA_c05710	COG0456	acetyltransferase
CLSA_c05720	COG1214	PFAM Peptidase M22, glycoprotease
CLSA_c05730	COG0802	atpase or kinase
CLSA_c05800	COG1136	(ABC) transporter
CLSA_c05870	COG1592	Rubrerythrin
CLSA_c05870	COG1773	rubredoxin
CLSA_c05880	COG0426	domain, Protein
CLSA_c05890	COG0251	oxidation-reduction process
CLSA_c05900	COG2070	2-Nitropropane dioxygenase
CLSA_c05960	COG0803	Belongs to the bacterial solute-binding protein 9 family
CLSA_c05970	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
CLSA_c06050	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
CLSA_c06050	COG0539	negative regulation of cytoplasmic translation
CLSA_c06070	COG2195	Cleaves the N-terminal amino acid of tripeptides
CLSA_c06080	COG0791	NLP P60 protein
CLSA_c06100	COG0424	maF-like protein
CLSA_c06110	COG2003	Belongs to the UPF0758 family
CLSA_c06120	COG1077	Cell shape determining protein MreB Mrl
CLSA_c06130	COG1792	Involved in formation and maintenance of cell shape
CLSA_c06160	COG1489	DNA binding
CLSA_c06180	COG2894	cell division
CLSA_c06190	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
CLSA_c06200	COG0772	Belongs to the SEDS family
CLSA_c06240	COG0745	RESPONSE REGULATOR receiver
CLSA_c06250	COG2205	protein histidine kinase activity
CLSA_c06300	COG0745	RESPONSE REGULATOR receiver
CLSA_c06350	COG5002	protein histidine kinase activity
CLSA_c06390	COG1530	ribonuclease E activity
CLSA_c06420	COG0211	Belongs to the bacterial ribosomal protein bL27 family
CLSA_c06430	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
CLSA_c06440	COG1534	Rna-binding protein
CLSA_c06450	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
CLSA_c06460	COG1713	HD superfamily hydrolase involved in NAD metabolism
CLSA_c06470	COG1316	TRANSCRIPTIONal
CLSA_c06480	COG0564	pseudouridine synthase activity
CLSA_c06490	COG1686	Belongs to the peptidase S11 family
CLSA_c06500	COG1555	photosystem II stabilization
CLSA_c06500	COG1596	polysaccharide export
CLSA_c06570	COG2310	stress, protein
CLSA_c06590	COG2310	stress, protein
CLSA_c06610	COG0861	Integral membrane protein TerC family
CLSA_c06650	COG0443	Heat shock 70 kDa protein
CLSA_c06660	COG0443	Heat shock 70 kDa protein
CLSA_c06680	COG0443	Heat shock 70 kDa protein
CLSA_c06700	COG1131	(ABC) transporter
CLSA_c06730	COG3507	Belongs to the glycosyl hydrolase 43 family
CLSA_c06740	COG0737	Belongs to the 5'-nucleotidase family
CLSA_c06750	COG1966	Carbon starvation protein
CLSA_c06800	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
CLSA_c06810	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
CLSA_c06820	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
CLSA_c06830	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
CLSA_c06840	COG0077	Prephenate dehydratase
CLSA_c06840	COG1605	Chorismate mutase
CLSA_c06850	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CLSA_c06880	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
CLSA_c06900	COG3507	Belongs to the glycosyl hydrolase 43 family
CLSA_c06910	COG0726	polysaccharide deacetylase
CLSA_c06970	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
CLSA_c06980	COG0583	DNA-binding transcription factor activity
CLSA_c07000	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CLSA_c07010	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CLSA_c07020	COG0738	Major facilitator superfamily
CLSA_c07040	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CLSA_c07050	COG0738	Major facilitator superfamily
CLSA_c07060	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
CLSA_c07090	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
CLSA_c07140	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
CLSA_c07150	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CLSA_c07160	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
CLSA_c07170	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
CLSA_c07180	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
CLSA_c07190	COG0165	Argininosuccinate lyase
CLSA_c07200	COG0137	argininosuccinate synthase activity
CLSA_c07220	COG2323	membrane
CLSA_c07230	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
CLSA_c07240	COG0840	transmembrane signaling receptor activity
CLSA_c07250	COG1760	l-serine dehydratase
CLSA_c07260	COG1760	l-serine dehydratase
CLSA_c07270	COG0745	RESPONSE REGULATOR receiver
CLSA_c07280	COG5002	protein histidine kinase activity
CLSA_c07300	COG0348	domain, Protein
CLSA_c07300	COG3901	Regulator of nitric oxide reductase transcription
CLSA_c07350	COG0351	phosphomethylpyrimidine kinase
CLSA_c07370	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
CLSA_c07380	COG0352	thiamine-phosphate diphosphorylase activity
CLSA_c07390	COG3706	GGDEF domain
CLSA_c07400	COG0514	ATP-dependent DNA helicase (RecQ)
CLSA_c07410	COG0613	PHP domain protein
CLSA_c07420	COG1126	abc transporter atp-binding protein
CLSA_c07430	COG0765	amino acid transport
CLSA_c07440	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CLSA_c07450	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CLSA_c07470	COG2207	Transcriptional regulator
CLSA_c07470	COG4753	response regulator
CLSA_c07490	COG1879	ABC-type sugar transport system periplasmic component
CLSA_c07500	COG1129	ABC transporter
CLSA_c07510	COG1172	Belongs to the binding-protein-dependent transport system permease family
CLSA_c07520	COG1172	Belongs to the binding-protein-dependent transport system permease family
CLSA_c07530	COG2972	Histidine kinase
CLSA_c07550	COG0561	phosphatase activity
CLSA_c07560	COG2160	L-arabinose isomerase activity
CLSA_c07600	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
CLSA_c07620	COG2814	Major facilitator Superfamily
CLSA_c07660	COG0288	reversible hydration of carbon dioxide
CLSA_c07690	COG5278	phosphoserine phosphatase activity
CLSA_c07690	COG0840	transmembrane signaling receptor activity
CLSA_c07750	COG1982	Orn Lys Arg decarboxylase major
CLSA_c07760	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
CLSA_c08040	COG0484	heat shock protein binding
CLSA_c08510	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
CLSA_c08520	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
CLSA_c08530	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
CLSA_c08540	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
CLSA_c08580	COG1454	alcohol dehydrogenase
CLSA_c08600	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CLSA_c08610	COG0765	amino acid transport
CLSA_c08620	COG2508	Transcriptional regulator
CLSA_c08630	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
CLSA_c08660	COG2207	Transcriptional regulator
CLSA_c08680	COG1725	Transcriptional regulator
CLSA_c08690	COG1131	(ABC) transporter
CLSA_c08740	COG0028	Belongs to the TPP enzyme family
CLSA_c08740	COG4032	Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
CLSA_c08790	COG0643	Histidine kinase
CLSA_c08790	COG2198	Histidine kinase
CLSA_c08810	COG0493	'glutamate synthase
CLSA_c08810	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
CLSA_c08820	COG2364	Membrane
CLSA_c08840	COG2801	Transposase and inactivated derivatives
CLSA_c08960	COG1053	succinate dehydrogenase
CLSA_c08960	COG0431	NADPH-dependent FMN reductase
CLSA_c08960	COG3976	FMN-binding domain protein
CLSA_c09010	COG3328	transposase activity
CLSA_c09180	COG3617	BRO family, N-terminal domain
CLSA_c09250	COG4978	Transcriptional regulator
CLSA_c09250	COG0789	Transcriptional regulator
CLSA_c09340	COG0629	single-stranded DNA binding
CLSA_c09350	COG0640	Transcriptional regulator
CLSA_c09370	COG0025	NhaP-type Na H and K H
CLSA_c09410	COG5520	Belongs to the glycosyl hydrolase 30 family
CLSA_c09430	COG0840	transmembrane signaling receptor activity
CLSA_c09460	COG2801	Transposase and inactivated derivatives
CLSA_c09530	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
CLSA_c09540	COG1136	(ABC) transporter
CLSA_c09560	COG4555	ABC transporter
CLSA_c09590	COG0745	RESPONSE REGULATOR receiver
CLSA_c09600	COG2205	protein histidine kinase activity
CLSA_c09630	COG0363	glucosamine-6-phosphate deaminase activity
CLSA_c09650	COG3715	PTS system
CLSA_c09660	COG3716	PTS system mannose fructose sorbose family IID component
CLSA_c09810	COG3328	transposase activity
CLSA_c09820	COG2723	6-phospho-beta-galactosidase activity
CLSA_c09840	COG3711	transcriptional antiterminator
CLSA_c09840	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CLSA_c09850	COG1447	Phosphotransferase system cellobiose-specific component IIA
CLSA_c09870	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CLSA_c09880	COG0823	Involved in the tonB-independent uptake of proteins
CLSA_c09910	COG1940	carbohydrate kinase activity
CLSA_c09920	COG2723	6-phospho-beta-galactosidase activity
CLSA_c09940	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CLSA_c09950	COG1447	Phosphotransferase system cellobiose-specific component IIA
CLSA_c10000	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
CLSA_c10040	COG2207	Transcriptional regulator
CLSA_c10040	COG3708	Transcriptional regulator
CLSA_c10070	COG1263	PTS System
CLSA_c10070	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CLSA_c10070	COG2190	(PTS) system
CLSA_c10080	COG3711	transcriptional antiterminator
CLSA_c10090	COG3279	Response regulator of the LytR AlgR family
CLSA_c10100	COG1131	(ABC) transporter
CLSA_c10150	COG1566	PFAM secretion protein HlyD family protein
CLSA_c10160	COG2814	Major facilitator Superfamily
CLSA_c10170	COG1846	Transcriptional regulator
CLSA_c10180	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
CLSA_c10190	COG1360	Flagellar Motor Protein
CLSA_c10200	COG0840	transmembrane signaling receptor activity
CLSA_c10210	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
CLSA_c10220	COG0698	ribose 5-phosphate isomerase
CLSA_c10230	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
CLSA_c10240	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
CLSA_c10260	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
CLSA_c10280	COG1737	Transcriptional regulator
CLSA_c10290	COG4989	oxidoreductase activity
CLSA_c10360	COG0840	transmembrane signaling receptor activity
CLSA_c10380	COG1846	Transcriptional regulator
CLSA_c10400	COG1349	DNA-binding transcription factor activity
CLSA_c10430	COG1253	flavin adenine dinucleotide binding
CLSA_c10440	COG0531	amino acid
CLSA_c10460	COG1131	(ABC) transporter
CLSA_c10470	COG1725	Transcriptional regulator
CLSA_c10510	COG0157	Belongs to the NadC ModD family
CLSA_c10520	COG3850	Histidine kinase
CLSA_c10520	COG5002	protein histidine kinase activity
CLSA_c10530	COG0745	RESPONSE REGULATOR receiver
CLSA_c10560	COG1136	(ABC) transporter
CLSA_c10570	COG0577	efflux transmembrane transporter activity
CLSA_c10600	COG2801	Transposase and inactivated derivatives
CLSA_c10610	COG0110	maltose O-acetyltransferase activity
CLSA_c10620	COG0840	transmembrane signaling receptor activity
CLSA_c10650	COG1067	ATP-dependent peptidase activity
CLSA_c10670	COG2172	sigma factor antagonist activity
CLSA_c10700	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CLSA_c10720	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
CLSA_c10740	COG1466	dna polymerase III delta subunit
CLSA_c10750	COG0268	Binds directly to 16S ribosomal RNA
CLSA_c10780	COG2801	Transposase and inactivated derivatives
CLSA_c10820	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CLSA_c10830	COG1420	regulation of RNA biosynthetic process
CLSA_c10840	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
CLSA_c10850	COG0443	Heat shock 70 kDa protein
CLSA_c10860	COG0484	heat shock protein binding
CLSA_c10870	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CLSA_c10880	COG0220	tRNA (guanine-N7-)-methyltransferase activity
CLSA_c10890	COG2264	protein methyltransferase activity
CLSA_c10900	COG1385	rRNA (uridine-N3-)-methyltransferase activity
CLSA_c10910	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CLSA_c10920	COG0537	adenosine 5'-monophosphoramidase activity
CLSA_c10940	COG1610	YqeY-like protein
CLSA_c10970	COG1480	7TM receptor with intracellular HD hydrolase
CLSA_c10980	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
CLSA_c10990	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
CLSA_c11000	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
CLSA_c11030	COG0517	IMP dehydrogenase activity
CLSA_c11040	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CLSA_c11040	COG0574	Belongs to the PEP-utilizing enzyme family
CLSA_c11070	COG0358	DNA primase activity
CLSA_c11080	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
CLSA_c11180	COG0745	RESPONSE REGULATOR receiver
CLSA_c11210	COG0697	spore germination
CLSA_c11220	COG1404	Belongs to the peptidase S8 family
CLSA_c11260	COG0058	SHG alpha-glucan phosphorylase activity
CLSA_c11270	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CLSA_c11280	COG0561	phosphatase activity
CLSA_c11290	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
CLSA_c11300	COG0512	Glutamine amidotransferase of anthranilate synthase
CLSA_c11300	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CLSA_c11320	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CLSA_c11330	COG1254	Belongs to the acylphosphatase family
CLSA_c11340	COG0105	UTP biosynthetic process
CLSA_c11370	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CLSA_c11400	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
CLSA_c11430	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CLSA_c11440	COG1739	Uncharacterized protein family UPF0029
CLSA_c11470	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
CLSA_c11480	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
CLSA_c11580	COG3706	GGDEF domain
CLSA_c11590	COG0586	Pfam SNARE associated Golgi protein
CLSA_c11600	COG0527	aspartate kinase activity
CLSA_c11630	COG0069	glutamate synthase activity
CLSA_c11630	COG0070	glutamate synthase
CLSA_c11630	COG0067	glutamate synthase
CLSA_c11640	COG0493	'glutamate synthase
CLSA_c11660	COG0538	isocitrate dehydrogenase activity
CLSA_c11680	COG2610	gluconate transmembrane transporter activity
CLSA_c11690	COG1929	Belongs to the glycerate kinase type-1 family
CLSA_c11700	COG3835	regulator
CLSA_c11740	COG2309	aminopeptidase activity
CLSA_c11750	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CLSA_c11750	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CLSA_c11770	COG0741	lytic transglycosylase activity
CLSA_c11900	COG2936	dipeptidyl-peptidase activity
CLSA_c11930	COG5002	protein histidine kinase activity
CLSA_c11970	COG2226	methyltransferase
CLSA_c11990	COG0004	ammonium transporteR
CLSA_c12000	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CLSA_c12010	COG1116	anion transmembrane transporter activity
CLSA_c12020	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CLSA_c12040	COG1346	cytolysis
CLSA_c12070	COG1686	Belongs to the peptidase S11 family
CLSA_c12090	COG1349	DNA-binding transcription factor activity
CLSA_c12100	COG1454	alcohol dehydrogenase
CLSA_c12110	COG0191	fructose-bisphosphate aldolase activity
CLSA_c12120	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CLSA_c12130	COG3718	enzyme involved in inositol metabolism
CLSA_c12150	COG0673	inositol 2-dehydrogenase activity
CLSA_c12160	COG1082	Xylose isomerase domain protein TIM barrel
CLSA_c12170	COG2814	Major facilitator Superfamily
CLSA_c12180	COG3442	glutamine amidotransferase
CLSA_c12190	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
CLSA_c12210	COG0826	peptidase U32
CLSA_c12220	COG1193	negative regulation of DNA recombination
CLSA_c12230	COG1683	Conserved Protein
CLSA_c12250	COG0420	3'-5' exonuclease activity
CLSA_c12260	COG0419	ATPase involved in DNA repair
CLSA_c12270	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
CLSA_c12280	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
CLSA_c12290	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CLSA_c12310	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
CLSA_c12320	COG0728	peptidoglycan biosynthetic process
CLSA_c12340	COG0438	transferase activity, transferring glycosyl groups
CLSA_c12390	COG0012	GTP binding
CLSA_c12410	COG1482	cell wall glycoprotein biosynthetic process
CLSA_c12450	COG0540	Belongs to the ATCase OTCase family
CLSA_c12510	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
CLSA_c12590	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
CLSA_c12590	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
CLSA_c12600	COG4632	Exopolysaccharide biosynthesis protein
CLSA_c12600	COG5434	Belongs to the glycosyl hydrolase 28 family
CLSA_c12620	COG1994	Peptidase M50
CLSA_c12630	COG0018	arginyl-trna synthetase
CLSA_c12640	COG0628	permease
CLSA_c12650	COG0778	Nitroreductase
CLSA_c12730	COG2155	Conserved Protein
CLSA_c12740	COG1522	sequence-specific DNA binding
CLSA_c12790	COG0367	asparagine synthase
CLSA_c12830	COG1116	anion transmembrane transporter activity
CLSA_c12850	COG3118	belongs to the thioredoxin family
CLSA_c12870	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CLSA_c12880	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CLSA_c12880	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
CLSA_c12920	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CLSA_c12930	COG0765	amino acid transport
CLSA_c12960	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CLSA_c12970	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
CLSA_c12990	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
CLSA_c13000	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
CLSA_c13010	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
CLSA_c13020	COG0138	bifunctional purine biosynthesis protein purh
CLSA_c13030	COG0151	Belongs to the GarS family
CLSA_c13080	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CLSA_c13110	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
CLSA_c13120	COG1028	Short-chain dehydrogenase reductase Sdr
CLSA_c13130	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CLSA_c13140	COG0511	ligase activity, forming carbon-carbon bonds
CLSA_c13160	COG0439	Biotin carboxylase
CLSA_c13170	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
CLSA_c13180	COG0825	malonyl-CoA metabolic process
CLSA_c13200	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
CLSA_c13210	COG1959	2 iron, 2 sulfur cluster binding
CLSA_c13230	COG0822	iron-sulfur transferase activity
CLSA_c13240	COG0482	sulfurtransferase activity
CLSA_c13260	COG0628	permease
CLSA_c13270	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
CLSA_c13290	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
CLSA_c13310	COG0735	belongs to the Fur family
CLSA_c13320	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
CLSA_c13340	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
CLSA_c13370	COG0768	penicillin binding
CLSA_c13380	COG1191	sigma factor activity
CLSA_c13400	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
CLSA_c13420	COG1191	sigma factor activity
CLSA_c13430	COG1191	sigma factor activity
CLSA_c13440	COG1873	PFAM PRC-barrel domain
CLSA_c13450	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
CLSA_c13470	COG0745	RESPONSE REGULATOR receiver
CLSA_c13480	COG5002	protein histidine kinase activity
CLSA_c13490	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
CLSA_c13500	COG0573	inorganic phosphate transmembrane transporter activity
CLSA_c13510	COG0581	inorganic phosphate transmembrane transporter activity
CLSA_c13520	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CLSA_c13530	COG0704	Plays a role in the regulation of phosphate uptake
CLSA_c13550	COG1160	GTP binding
CLSA_c13560	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
CLSA_c13590	COG2252	PERMEase
CLSA_c13600	COG1561	YicC-like family, N-terminal region
CLSA_c13620	COG0194	GDP metabolic process
CLSA_c13630	COG1758	RNA polymerase activity
CLSA_c13640	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
CLSA_c13650	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
CLSA_c13670	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
CLSA_c13680	COG2738	Putative neutral zinc metallopeptidase
CLSA_c13690	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CLSA_c13690	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
CLSA_c13700	COG0820	rRNA (adenine-C2-)-methyltransferase activity
CLSA_c13710	COG0631	protein serine/threonine phosphatase activity
CLSA_c13730	COG1162	GTPase activity
CLSA_c13740	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
CLSA_c13750	COG1564	THIamine pyrophosphokinase
CLSA_c13760	COG0227	Belongs to the bacterial ribosomal protein bL28 family
CLSA_c13770	COG1302	Protein conserved in bacteria
CLSA_c13780	COG1461	Dihydroxyacetone kinase
CLSA_c13790	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
CLSA_c13800	COG0742	ribosomal rna small subunit methyltransferase
CLSA_c13810	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
CLSA_c13840	COG1323	Belongs to the UPF0348 family
CLSA_c13850	COG0280	phosphate acetyltransferase
CLSA_c13860	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
CLSA_c13880	COG0333	Belongs to the bacterial ribosomal protein bL32 family
CLSA_c13890	COG0416	fatty acid biosynthetic process
CLSA_c13900	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CLSA_c13910	COG0571	ribonuclease III activity
CLSA_c13940	COG0552	protein localization to endoplasmic reticulum
CLSA_c13950	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
CLSA_c13960	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
CLSA_c13970	COG0228	four-way junction DNA binding
CLSA_c13980	COG1837	Belongs to the UPF0109 family
CLSA_c13990	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
CLSA_c14000	COG0336	Belongs to the RNA methyltransferase TrmD family
CLSA_c14010	COG0335	large ribosomal subunit rRNA binding
CLSA_c14030	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
CLSA_c14040	COG3328	transposase activity
CLSA_c14050	COG0792	nuclease activity
CLSA_c14060	COG0606	chelatase, subunit chli
CLSA_c14070	COG0758	DNA mediated transformation
CLSA_c14080	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CLSA_c14090	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
CLSA_c14100	COG0052	Belongs to the universal ribosomal protein uS2 family
CLSA_c14150	COG4589	Belongs to the CDS family
CLSA_c14360	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
CLSA_c14370	COG0779	Required for maturation of 30S ribosomal subunits
CLSA_c14380	COG0195	Participates in both transcription termination and antitermination
CLSA_c14390	COG2740	Nucleic-acid-binding protein implicated in transcription termination
CLSA_c14410	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
CLSA_c14420	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
CLSA_c14450	COG0196	riboflavin kinase activity
CLSA_c14460	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
CLSA_c14470	COG1185	polyribonucleotide nucleotidyltransferase activity
CLSA_c14480	COG0612	Peptidase, M16
CLSA_c14500	COG0527	aspartate kinase activity
CLSA_c14510	COG0740	serine-type endopeptidase activity
CLSA_c14530	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CLSA_c14540	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CLSA_c14550	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
CLSA_c14560	COG1418	mRNA catabolic process
CLSA_c14570	COG2359	stage V sporulation protein S
CLSA_c14580	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CLSA_c14590	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
CLSA_c14640	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CLSA_c14640	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
CLSA_c14680	COG1125	glycine betaine transport
CLSA_c14680	COG0517	IMP dehydrogenase activity
CLSA_c14690	COG1174	glycine betaine transport
CLSA_c14710	COG1592	Rubrerythrin
CLSA_c14710	COG1773	rubredoxin
CLSA_c14720	COG0778	Nitroreductase
CLSA_c14810	COG0371	Dehydrogenase
CLSA_c14820	COG3328	transposase activity
CLSA_c14840	COG1959	2 iron, 2 sulfur cluster binding
CLSA_c14930	COG0583	DNA-binding transcription factor activity
CLSA_c14950	COG0784	Response regulator, receiver
CLSA_c14950	COG0835	chemotaxis
CLSA_c14970	COG1924	4 iron, 4 sulfur cluster binding
CLSA_c15010	COG0446	pyridine nucleotide-disulphide oxidoreductase
CLSA_c15020	COG1550	Protein conserved in bacteria
CLSA_c15030	COG1733	regulation of RNA biosynthetic process
CLSA_c15050	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
CLSA_c15070	COG0628	permease
CLSA_c15080	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
CLSA_c15100	COG0693	protein deglycase activity
CLSA_c15110	COG2378	regulation of single-species biofilm formation
CLSA_c15140	COG1695	Transcriptional regulator
CLSA_c15210	COG1012	belongs to the aldehyde dehydrogenase family
CLSA_c15230	COG2703	oxygen carrier activity
CLSA_c15250	COG0671	phosphoesterase, PA-phosphatase related
CLSA_c15280	COG1027	Aspartate ammonia-lyase
CLSA_c15290	COG1522	sequence-specific DNA binding
CLSA_c15300	COG2226	methyltransferase
CLSA_c15330	COG0726	polysaccharide deacetylase
CLSA_c15350	COG3830	Belongs to the UPF0237 family
CLSA_c15360	COG2848	UPF0210 protein
CLSA_c15410	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CLSA_c15420	COG0708	Exodeoxyribonuclease III
CLSA_c15470	COG1234	tRNA 3'-trailer cleavage
CLSA_c15530	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
CLSA_c15600	COG0602	queuosine metabolic process
CLSA_c15610	COG0302	gtp cyclohydrolase
CLSA_c15620	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
CLSA_c15630	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
CLSA_c15680	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
CLSA_c15730	COG0494	nUDIX hydrolase
CLSA_c15740	COG3546	catalase activity
CLSA_c15770	COG1056	cytidyltransferase-related domain
CLSA_c15770	COG1051	belongs to the nudix hydrolase family
CLSA_c15820	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
CLSA_c15850	COG0517	IMP dehydrogenase activity
CLSA_c15890	COG1129	ABC transporter
CLSA_c15900	COG1172	Belongs to the binding-protein-dependent transport system permease family
CLSA_c15910	COG1879	ABC-type sugar transport system periplasmic component
CLSA_c15920	COG1609	Transcriptional regulator
CLSA_c16050	COG0242	peptide deformylase activity
CLSA_c16160	COG0493	'glutamate synthase
CLSA_c16210	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CLSA_c16310	COG3963	phosphatidate phosphatase activity
CLSA_c16360	COG2205	protein histidine kinase activity
CLSA_c16370	COG1309	transcriptional regulator
CLSA_c16380	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CLSA_c16390	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CLSA_c16400	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
CLSA_c16410	COG1882	Formate acetyltransferase
CLSA_c16470	COG3189	MarR family transcriptional regulator
CLSA_c16520	COG0789	Transcriptional regulator
CLSA_c16540	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
CLSA_c16560	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
CLSA_c16650	COG2177	Part of the ABC transporter FtsEX involved in
CLSA_c16690	COG1879	ABC-type sugar transport system periplasmic component
CLSA_c16750	COG0798	PFAM Bile acid sodium symporter
CLSA_c16790	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
CLSA_c16800	COG0659	secondary active sulfate transmembrane transporter activity
CLSA_c16810	COG2226	methyltransferase
CLSA_c16840	COG2199	diguanylate cyclase activity
CLSA_c16840	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
CLSA_c16860	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
CLSA_c16870	COG2207	Transcriptional regulator
CLSA_c16880	COG1169	isochorismate synthase
CLSA_c16910	COG2091	lysine biosynthetic process via aminoadipic acid
CLSA_c16920	COG1021	2,3-dihydroxybenzoate-AMP ligase
CLSA_c16930	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CLSA_c16930	COG2226	methyltransferase
CLSA_c16930	COG3433	isochorismatase activity
CLSA_c16940	COG3433	isochorismatase activity
CLSA_c16940	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CLSA_c16940	COG2226	methyltransferase
CLSA_c17000	COG1129	ABC transporter
CLSA_c17010	COG1132	(ABC) transporter
CLSA_c17020	COG1132	(ABC) transporter
CLSA_c17040	COG0840	transmembrane signaling receptor activity
CLSA_c17110	COG2207	Transcriptional regulator
CLSA_c17130	COG1132	(ABC) transporter
CLSA_c17150	COG1342	Belongs to the UPF0251 family
CLSA_c17270	COG0440	acetolactate synthase activity
CLSA_c17280	COG0028	Belongs to the TPP enzyme family
CLSA_c17310	COG1329	Transcriptional regulator
CLSA_c17320	COG1619	proteins homologs of microcin C7 resistance protein MccF
CLSA_c17360	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CLSA_c17370	COG5002	protein histidine kinase activity
CLSA_c17380	COG2273	Hydrolase Family 16
CLSA_c17390	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CLSA_c17430	COG0701	Predicted permease
CLSA_c17460	COG1028	Short-chain dehydrogenase reductase Sdr
CLSA_c17520	COG0697	spore germination
CLSA_c17530	COG0561	phosphatase activity
CLSA_c17560	COG0310	cobalt ion transport
CLSA_c17580	COG1122	ATPase activity
CLSA_c17590	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
CLSA_c17600	COG1606	tRNA processing
CLSA_c17610	COG1691	(AIR) carboxylase
CLSA_c17640	COG0024	Methionine aminopeptidase
CLSA_c17650	COG0514	ATP-dependent DNA helicase (RecQ)
CLSA_c17670	COG0484	heat shock protein binding
CLSA_c17680	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CLSA_c17690	COG1191	sigma factor activity
CLSA_c17710	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
CLSA_c17710	COG0646	methionine synthase
CLSA_c17720	COG0493	'glutamate synthase
CLSA_c17730	COG0531	amino acid
CLSA_c17760	COG2217	Heavy metal translocating P-type atpase
CLSA_c17780	COG2814	Major facilitator Superfamily
CLSA_c17800	COG2267	carboxylic ester hydrolase activity
CLSA_c17810	COG0583	DNA-binding transcription factor activity
CLSA_c17830	COG0436	Aminotransferase
CLSA_c17850	COG3711	transcriptional antiterminator
CLSA_c17860	COG2190	(PTS) system
CLSA_c17860	COG1263	PTS System
CLSA_c17860	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CLSA_c17880	COG1802	Transcriptional regulator
CLSA_c17890	COG0523	cobalamin synthesis protein
CLSA_c17910	COG0840	transmembrane signaling receptor activity
CLSA_c17930	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
CLSA_c17960	COG0789	Transcriptional regulator
CLSA_c17970	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
CLSA_c18040	COG3933	PFAM sigma-54 factor interaction domain-containing protein
CLSA_c18040	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
CLSA_c18060	COG3414	Phosphotransferase system galactitol-specific IIB component
CLSA_c18070	COG3775	system Galactitol-specific IIC component
CLSA_c18080	COG0371	Dehydrogenase
CLSA_c18110	COG0477	Major facilitator Superfamily
CLSA_c18130	COG0840	transmembrane signaling receptor activity
CLSA_c18150	COG0531	amino acid
CLSA_c18170	COG5278	phosphoserine phosphatase activity
CLSA_c18170	COG0840	transmembrane signaling receptor activity
CLSA_c18180	COG0778	Nitroreductase
CLSA_c18190	COG0840	transmembrane signaling receptor activity
CLSA_c18210	COG2207	Transcriptional regulator
CLSA_c18240	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CLSA_c18250	COG1132	(ABC) transporter
CLSA_c18260	COG1132	(ABC) transporter
CLSA_c18280	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CLSA_c18290	COG3608	succinylglutamate desuccinylase aspartoacylase
CLSA_c18290	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
CLSA_c18320	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
CLSA_c18330	COG1924	4 iron, 4 sulfur cluster binding
CLSA_c18370	COG2080	2 iron, 2 sulfur cluster binding
CLSA_c18370	COG1529	Aldehyde oxidase and xanthine dehydrogenase
CLSA_c18380	COG3608	succinylglutamate desuccinylase aspartoacylase
CLSA_c18380	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
CLSA_c18510	COG0346	lactoylglutathione lyase activity
CLSA_c18520	COG2205	protein histidine kinase activity
CLSA_c18520	COG0745	RESPONSE REGULATOR receiver
CLSA_c18520	COG4191	Histidine kinase
CLSA_c18530	COG1960	acyl-CoA dehydrogenase activity
CLSA_c18540	COG0426	domain, Protein
CLSA_c18550	COG1393	Belongs to the ArsC family
CLSA_c18580	COG0494	nUDIX hydrolase
CLSA_c18600	COG1027	Aspartate ammonia-lyase
CLSA_c18610	COG1160	GTP binding
CLSA_c18720	COG1113	amino acid transport
CLSA_c18740	COG1695	Transcriptional regulator
CLSA_c18760	COG0840	transmembrane signaling receptor activity
CLSA_c18800	COG0840	transmembrane signaling receptor activity
CLSA_c18810	COG2521	methyltransferase
CLSA_c18810	COG2136	Putative SAM-dependent methyltransferase
CLSA_c18840	COG0840	transmembrane signaling receptor activity
CLSA_c18850	COG0367	asparagine synthase
CLSA_c18860	COG0004	ammonium transporteR
CLSA_c18930	COG1846	Transcriptional regulator
CLSA_c18990	COG5002	protein histidine kinase activity
CLSA_c19040	COG2086	electron transfer activity
CLSA_c19050	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
CLSA_c19060	COG1620	l-lactate permease
CLSA_c19080	COG1960	acyl-CoA dehydrogenase activity
CLSA_c19090	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CLSA_c19130	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CLSA_c19150	COG1695	Transcriptional regulator
CLSA_c19170	COG0488	(ABC) transporter
CLSA_c19200	COG0667	Aldo Keto reductase
CLSA_c19270	COG0326	Molecular chaperone. Has ATPase activity
CLSA_c19300	COG0326	Molecular chaperone. Has ATPase activity
CLSA_c19360	COG0824	Thioesterase
CLSA_c19370	COG0840	transmembrane signaling receptor activity
CLSA_c19400	COG0860	N-Acetylmuramoyl-L-alanine amidase
CLSA_c19400	COG2247	cell wall binding repeat
CLSA_c19420	COG4978	Transcriptional regulator
CLSA_c19420	COG0789	Transcriptional regulator
CLSA_c19440	COG1132	(ABC) transporter
CLSA_c19470	COG1609	Transcriptional regulator
CLSA_c19490	COG2211	Major facilitator Superfamily
CLSA_c19500	COG1904	glucuronate isomerase
CLSA_c19510	COG0800	Aldolase
CLSA_c19520	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CLSA_c19530	COG0246	Mannitol dehydrogenase
CLSA_c19540	COG2721	sulfolactate sulfo-lyase activity
CLSA_c19560	COG1695	Transcriptional regulator
CLSA_c19650	COG0840	transmembrane signaling receptor activity
CLSA_c19690	COG2223	nitrite transmembrane transporter activity
CLSA_c19700	COG3279	Response regulator of the LytR AlgR family
CLSA_c19710	COG3275	phosphorelay sensor kinase activity
CLSA_c19790	COG0534	Mate efflux family protein
CLSA_c19870	COG1595	DNA-templated transcription, initiation
CLSA_c20000	COG1309	transcriptional regulator
CLSA_c20020	COG1846	Transcriptional regulator
CLSA_c20030	COG0534	Mate efflux family protein
CLSA_c20040	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
CLSA_c20050	COG0643	Histidine kinase
CLSA_c20050	COG2198	Histidine kinase
CLSA_c20060	COG2201	protein-glutamate methylesterase activity
CLSA_c20070	COG0835	chemotaxis
CLSA_c20080	COG0840	transmembrane signaling receptor activity
CLSA_c20090	COG1136	(ABC) transporter
CLSA_c20120	COG1136	(ABC) transporter
CLSA_c20140	COG0745	RESPONSE REGULATOR receiver
CLSA_c20150	COG2205	protein histidine kinase activity
CLSA_c20150	COG2202	Pas domain
CLSA_c20230	COG0745	RESPONSE REGULATOR receiver
CLSA_c20270	COG2205	protein histidine kinase activity
CLSA_c20300	COG2207	Transcriptional regulator
CLSA_c20300	COG1917	Cupin 2, conserved barrel domain protein
CLSA_c20310	COG0697	spore germination
CLSA_c20340	COG0488	(ABC) transporter
CLSA_c20360	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
CLSA_c20370	COG3706	GGDEF domain
CLSA_c20390	COG0835	chemotaxis
CLSA_c20400	COG2201	protein-glutamate methylesterase activity
CLSA_c20420	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
CLSA_c20430	COG2201	protein-glutamate methylesterase activity
CLSA_c20440	COG0643	Histidine kinase
CLSA_c20440	COG2198	Histidine kinase
CLSA_c20450	COG2201	protein-glutamate methylesterase activity
CLSA_c20480	COG1366	Belongs to the anti-sigma-factor antagonist family
CLSA_c20490	COG1366	Belongs to the anti-sigma-factor antagonist family
CLSA_c20500	COG2172	sigma factor antagonist activity
CLSA_c20520	COG3852	Histidine kinase
CLSA_c20530	COG2198	Histidine kinase
CLSA_c20530	COG0643	Histidine kinase
CLSA_c20560	COG1192	Involved in chromosome partitioning
CLSA_c20570	COG0835	chemotaxis
CLSA_c20580	COG2201	protein-glutamate methylesterase activity
CLSA_c20590	COG3328	transposase activity
CLSA_c20630	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
CLSA_c20630	COG3933	PFAM sigma-54 factor interaction domain-containing protein
CLSA_c20640	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
CLSA_c20640	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CLSA_c20650	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CLSA_c20650	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
CLSA_c20660	COG3715	PTS system
CLSA_c20670	COG3716	PTS system mannose fructose sorbose family IID component
CLSA_c20680	COG1621	beta-fructofuranosidase activity
CLSA_c20680	COG3583	domain protein
CLSA_c20680	COG5492	domain, Protein
CLSA_c20700	COG1609	Transcriptional regulator
CLSA_c20730	COG1846	Transcriptional regulator
CLSA_c20740	COG1289	transmembrane transporter activity
CLSA_c20800	COG0840	transmembrane signaling receptor activity
CLSA_c20840	COG0436	Aminotransferase
CLSA_c20850	COG0745	RESPONSE REGULATOR receiver
CLSA_c20880	COG2205	protein histidine kinase activity
CLSA_c20930	COG1074	ATP-dependent DNA helicase activity
CLSA_c20960	COG0745	RESPONSE REGULATOR receiver
CLSA_c20980	COG5002	protein histidine kinase activity
CLSA_c21040	COG1215	transferase activity, transferring glycosyl groups
CLSA_c21080	COG1937	Protein conserved in bacteria
CLSA_c21090	COG0601	transmembrane transport
CLSA_c21120	COG0444	Belongs to the ABC transporter superfamily
CLSA_c21130	COG4608	Belongs to the ABC transporter superfamily
CLSA_c21220	COG3384	dioxygenase
CLSA_c21260	COG0745	RESPONSE REGULATOR receiver
CLSA_c21270	COG2205	protein histidine kinase activity
CLSA_c21300	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
CLSA_c21310	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
CLSA_c21390	COG2390	Transcriptional regulator
CLSA_c21420	COG1172	Belongs to the binding-protein-dependent transport system permease family
CLSA_c21430	COG1879	ABC-type sugar transport system periplasmic component
CLSA_c21460	COG1988	membrane-bound metal-dependent
CLSA_c21500	COG3875	lactate racemase activity
CLSA_c21520	COG2801	Transposase and inactivated derivatives
CLSA_c21570	COG2814	Major facilitator Superfamily
CLSA_c21580	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
CLSA_c21620	COG1122	ATPase activity
CLSA_c21630	COG5001	Diguanylate cyclase
CLSA_c21630	COG3706	GGDEF domain
CLSA_c21630	COG2203	Gaf domain
CLSA_c21630	COG4251	negative regulation of phosphorylation
CLSA_c21650	COG0534	Mate efflux family protein
CLSA_c21680	COG0745	RESPONSE REGULATOR receiver
CLSA_c21700	COG5002	protein histidine kinase activity
CLSA_c21720	COG2207	Transcriptional regulator
CLSA_c21720	COG1917	Cupin 2, conserved barrel domain protein
CLSA_c21820	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
CLSA_c21830	COG3706	GGDEF domain
CLSA_c21840	COG0328	RNA-DNA hybrid ribonuclease activity
CLSA_c21870	COG3706	GGDEF domain
CLSA_c21870	COG0745	RESPONSE REGULATOR receiver
CLSA_c21880	COG1879	ABC-type sugar transport system periplasmic component
CLSA_c21890	COG5002	protein histidine kinase activity
CLSA_c21900	COG1879	ABC-type sugar transport system periplasmic component
CLSA_c21920	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
CLSA_c21940	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
CLSA_c21950	COG2176	DNA-directed DNA polymerase activity
CLSA_c21970	COG1132	(ABC) transporter
CLSA_c21980	COG3584	3D domain protein
CLSA_c21980	COG1388	LysM domain
CLSA_c21990	COG0765	amino acid transport
CLSA_c22000	COG0765	amino acid transport
CLSA_c22010	COG1126	abc transporter atp-binding protein
CLSA_c22030	COG3437	response regulator, receiver
CLSA_c22040	COG0784	Response regulator, receiver
CLSA_c22040	COG2205	protein histidine kinase activity
CLSA_c22040	COG5002	protein histidine kinase activity
CLSA_c22050	COG2201	protein-glutamate methylesterase activity
CLSA_c22070	COG1187	pseudouridine synthase activity
CLSA_c22100	COG1072	(Pantothenic acid kinase))
CLSA_c22110	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
CLSA_c22110	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CLSA_c22120	COG3715	PTS system
CLSA_c22130	COG3716	PTS system mannose fructose sorbose family IID component
CLSA_c22140	COG1349	DNA-binding transcription factor activity
CLSA_c22150	COG1105	Belongs to the carbohydrate kinase PfkB family
CLSA_c22160	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CLSA_c22160	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CLSA_c22160	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CLSA_c22190	COG2801	Transposase and inactivated derivatives
CLSA_c22230	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
CLSA_c22260	COG1131	(ABC) transporter
CLSA_c22290	COG1307	EDD domain protein, DegV family
CLSA_c22310	COG2081	HI0933 family
CLSA_c22320	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
CLSA_c22330	COG0539	negative regulation of cytoplasmic translation
CLSA_c22330	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
CLSA_c22370	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
CLSA_c22420	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
CLSA_c22430	COG4974	Belongs to the 'phage' integrase family
CLSA_c22460	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
CLSA_c22470	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
CLSA_c22480	COG1923	regulation of RNA biosynthetic process
CLSA_c22490	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
CLSA_c22500	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
CLSA_c22540	COG0318	PFAM AMP-dependent synthetase and ligase
CLSA_c22570	COG2086	electron transfer activity
CLSA_c22580	COG1960	acyl-CoA dehydrogenase activity
CLSA_c22620	COG2252	PERMEase
CLSA_c22640	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
CLSA_c22650	COG5663	Belongs to the 5'(3')-deoxyribonucleotidase family
CLSA_c22700	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
CLSA_c22720	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
CLSA_c22740	COG1012	belongs to the aldehyde dehydrogenase family
CLSA_c22750	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
CLSA_c22770	COG0730	response to heat
CLSA_c22830	COG2801	Transposase and inactivated derivatives
CLSA_c23010	COG0791	NLP P60 protein
CLSA_c23250	COG2201	protein-glutamate methylesterase activity
CLSA_c23260	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
CLSA_c23280	COG2198	Histidine kinase
CLSA_c23280	COG0643	Histidine kinase
CLSA_c23290	COG0835	chemotaxis
CLSA_c23300	COG2201	protein-glutamate methylesterase activity
CLSA_c23310	COG5002	protein histidine kinase activity
CLSA_c23360	COG2608	mercury ion transmembrane transporter activity
CLSA_c23380	COG2217	Heavy metal translocating P-type atpase
CLSA_c23390	COG5002	protein histidine kinase activity
CLSA_c23400	COG0745	RESPONSE REGULATOR receiver
CLSA_c23430	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CLSA_c23440	COG1285	pathogenesis
CLSA_c23470	COG0488	(ABC) transporter
CLSA_c23520	COG1268	BioY protein
CLSA_c23560	COG0159	tryptophan synthase activity
CLSA_c23570	COG0133	tryptophan synthase activity
CLSA_c23580	COG0135	phosphoribosylanthranilate isomerase activity
CLSA_c23590	COG0134	indole-3-glycerol-phosphate synthase activity
CLSA_c23600	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CLSA_c23610	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
CLSA_c23610	COG0512	Glutamine amidotransferase of anthranilate synthase
CLSA_c23630	COG1959	2 iron, 2 sulfur cluster binding
CLSA_c23660	COG0406	alpha-ribazole phosphatase activity
CLSA_c23730	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
CLSA_c23740	COG0346	lactoylglutathione lyase activity
CLSA_c23750	COG3328	transposase activity
CLSA_c23770	COG0306	phosphate transporter
CLSA_c23780	COG1392	Phosphate transport regulator
CLSA_c23840	COG2195	Cleaves the N-terminal amino acid of tripeptides
CLSA_c23850	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CLSA_c23880	COG0561	phosphatase activity
CLSA_c23950	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CLSA_c23980	COG0561	phosphatase activity
CLSA_c23990	COG1349	DNA-binding transcription factor activity
CLSA_c24000	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
CLSA_c24010	COG0840	transmembrane signaling receptor activity
CLSA_c24030	COG4978	Transcriptional regulator
CLSA_c24030	COG0789	Transcriptional regulator
CLSA_c24040	COG0534	Mate efflux family protein
CLSA_c24060	COG1773	rubredoxin
CLSA_c24060	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
CLSA_c24080	COG1113	amino acid transport
CLSA_c24100	COG3639	organic phosphonate transmembrane transporter activity
CLSA_c24120	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
CLSA_c24150	COG2201	protein-glutamate methylesterase activity
CLSA_c24180	COG0835	chemotaxis
CLSA_c24190	COG2198	Histidine kinase
CLSA_c24190	COG0643	Histidine kinase
CLSA_c24200	COG2201	protein-glutamate methylesterase activity
CLSA_c24230	COG2801	Transposase and inactivated derivatives
CLSA_c24260	COG0446	pyridine nucleotide-disulphide oxidoreductase
CLSA_c24310	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
CLSA_c24320	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
CLSA_c24330	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CLSA_c24340	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
CLSA_c24350	COG1802	Transcriptional regulator
CLSA_c24360	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CLSA_c24420	COG2226	methyltransferase
CLSA_c24430	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CLSA_c24450	COG1113	amino acid transport
CLSA_c24520	COG1116	anion transmembrane transporter activity
CLSA_c24530	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
CLSA_c24540	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
CLSA_c24560	COG0084	hydrolase, TatD family'
CLSA_c24580	COG5002	protein histidine kinase activity
CLSA_c24660	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
CLSA_c24670	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CLSA_c24680	COG0833	amino acid
CLSA_c24700	COG2040	homocysteine
CLSA_c24780	COG2962	Rard protein
CLSA_c24840	COG4129	membrane
CLSA_c24850	COG0367	asparagine synthase
CLSA_c24860	COG5002	protein histidine kinase activity
CLSA_c24890	COG0840	transmembrane signaling receptor activity
CLSA_c24910	COG1335	isochorismatase
CLSA_c24930	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
CLSA_c24940	COG1518	maintenance of DNA repeat elements
CLSA_c25010	COG0477	Major facilitator Superfamily
CLSA_c25040	COG1733	regulation of RNA biosynthetic process
CLSA_c25120	COG0352	thiamine-phosphate diphosphorylase activity
CLSA_c25140	COG2022	thiamine diphosphate biosynthetic process
CLSA_c25150	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
CLSA_c25170	COG3875	lactate racemase activity
CLSA_c25180	COG3546	catalase activity
CLSA_c25210	COG1902	pentaerythritol trinitrate reductase activity
CLSA_c25210	COG0446	pyridine nucleotide-disulphide oxidoreductase
CLSA_c25220	COG0543	2 iron, 2 sulfur cluster binding
CLSA_c25230	COG0583	DNA-binding transcription factor activity
CLSA_c25260	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
CLSA_c25270	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
CLSA_c25290	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
CLSA_c25300	COG0583	DNA-binding transcription factor activity
CLSA_c25310	COG0406	alpha-ribazole phosphatase activity
CLSA_c25340	COG0583	DNA-binding transcription factor activity
CLSA_c25350	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CLSA_c25370	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CLSA_c25400	COG1408	metallophosphoesterase
CLSA_c25410	COG2909	trisaccharide binding
CLSA_c25440	COG1131	(ABC) transporter
CLSA_c25490	COG1733	regulation of RNA biosynthetic process
CLSA_c25540	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CLSA_c25580	COG0110	maltose O-acetyltransferase activity
CLSA_c25610	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
CLSA_c25620	COG3708	Transcriptional regulator
CLSA_c25620	COG2207	Transcriptional regulator
CLSA_c25680	COG0477	Major facilitator Superfamily
CLSA_c25690	COG1309	transcriptional regulator
CLSA_c25720	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
CLSA_c25780	COG0791	NLP P60 protein
CLSA_c25790	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CLSA_c25830	COG1283	sodium-dependent phosphate transmembrane transporter activity
CLSA_c25840	COG0840	transmembrane signaling receptor activity
CLSA_c25900	COG0494	nUDIX hydrolase
CLSA_c25910	COG4708	membrane
CLSA_c25920	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CLSA_c25940	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
CLSA_c25940	COG1199	ATP-dependent helicase activity
CLSA_c25990	COG0551	DNA topoisomerase type I activity
CLSA_c25990	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CLSA_c26040	COG2909	trisaccharide binding
CLSA_c26050	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
CLSA_c26060	COG0583	DNA-binding transcription factor activity
CLSA_c26160	COG0768	penicillin binding
CLSA_c26170	COG0346	lactoylglutathione lyase activity
CLSA_c26200	COG1737	Transcriptional regulator
CLSA_c26210	COG1187	pseudouridine synthase activity
CLSA_c26240	COG0531	amino acid
CLSA_c26300	COG0445	tRNA wobble uridine modification
CLSA_c26310	COG1686	Belongs to the peptidase S11 family
CLSA_c26330	COG3874	Sporulation protein YtfJ
CLSA_c26340	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
CLSA_c26360	COG1686	Belongs to the peptidase S11 family
CLSA_c26370	COG1910	domain protein
CLSA_c26380	COG0725	ABC transporter, periplasmic molybdate-binding protein
CLSA_c26390	COG4149	molybdate abc transporter
CLSA_c26400	COG3842	ATPase activity
CLSA_c26420	COG0521	Mo-molybdopterin cofactor biosynthetic process
CLSA_c26470	COG0303	'Molybdopterin
CLSA_c26480	COG1546	Belongs to the CinA family
CLSA_c26480	COG1058	Belongs to the CinA family
CLSA_c26530	COG0243	molybdopterin cofactor binding
CLSA_c26540	COG2221	Nitrite and sulphite reductase 4Fe-4S
CLSA_c26580	COG2223	nitrite transmembrane transporter activity
CLSA_c26590	COG4974	Belongs to the 'phage' integrase family
CLSA_c26710	COG3328	transposase activity
CLSA_c26750	COG0653	protein targeting
CLSA_c26770	COG4974	Belongs to the 'phage' integrase family
CLSA_c26780	COG0745	RESPONSE REGULATOR receiver
CLSA_c26790	COG0750	zinc metalloprotease
CLSA_c26800	COG0497	DNA recombination
CLSA_c26810	COG1438	arginine binding
CLSA_c26820	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
CLSA_c26830	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
CLSA_c26840	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
CLSA_c26850	COG0142	geranyltranstransferase activity
CLSA_c26860	COG1722	exodeoxyribonuclease VII activity
CLSA_c26870	COG1570	exodeoxyribonuclease VII activity
CLSA_c26880	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
CLSA_c26890	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
CLSA_c26900	COG1302	Protein conserved in bacteria
CLSA_c26980	COG3854	ATPases associated with a variety of cellular activities
CLSA_c27160	COG1737	Transcriptional regulator
CLSA_c27170	COG0116	Belongs to the methyltransferase superfamily
CLSA_c27180	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
CLSA_c27190	COG0564	pseudouridine synthase activity
CLSA_c27200	COG3599	regulation of cell shape
CLSA_c27210	COG2302	S4 RNA-binding domain
CLSA_c27230	COG1799	cell septum assembly
CLSA_c27240	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
CLSA_c27260	COG3856	small basic protein
CLSA_c27290	COG0772	Belongs to the SEDS family
CLSA_c27300	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CLSA_c27310	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
CLSA_c27330	COG0768	penicillin binding
CLSA_c27350	COG0275	rRNA processing
CLSA_c27390	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CLSA_c27400	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
CLSA_c27470	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
CLSA_c27480	COG2226	methyltransferase
CLSA_c27500	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
CLSA_c27540	COG3123	guanosine phosphorylase activity
CLSA_c27550	COG0436	Aminotransferase
CLSA_c27560	COG2171	N-acyltransferase activity
CLSA_c27640	COG0861	Integral membrane protein TerC family
CLSA_c27690	COG1619	proteins homologs of microcin C7 resistance protein MccF
CLSA_c27750	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
CLSA_c27790	COG4632	Exopolysaccharide biosynthesis protein
CLSA_c27790	COG5434	Belongs to the glycosyl hydrolase 28 family
CLSA_c27810	COG0534	Mate efflux family protein
CLSA_c27830	COG4632	Exopolysaccharide biosynthesis protein
CLSA_c27830	COG5434	Belongs to the glycosyl hydrolase 28 family
CLSA_c27870	COG2137	regulation of response to DNA damage stimulus
CLSA_c27880	COG0612	Peptidase, M16
CLSA_c27890	COG0745	RESPONSE REGULATOR receiver
CLSA_c27900	COG5002	protein histidine kinase activity
CLSA_c27910	COG0252	asparaginase activity
CLSA_c27920	COG1028	Short-chain dehydrogenase reductase Sdr
CLSA_c27950	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
CLSA_c27960	COG2966	Psort location CytoplasmicMembrane, score
CLSA_c28010	COG2801	Transposase and inactivated derivatives
CLSA_c28050	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
CLSA_c28090	COG1187	pseudouridine synthase activity
CLSA_c28120	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CLSA_c28130	COG0183	Belongs to the thiolase family
CLSA_c28140	COG1268	BioY protein
CLSA_c28150	COG0488	(ABC) transporter
CLSA_c28180	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CLSA_c28190	COG0840	transmembrane signaling receptor activity
CLSA_c28210	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CLSA_c28220	COG0572	uridine kinase
CLSA_c28240	COG1329	Transcriptional regulator
CLSA_c28270	COG2271	Major facilitator Superfamily
CLSA_c28290	COG0446	pyridine nucleotide-disulphide oxidoreductase
CLSA_c28310	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
CLSA_c28320	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
CLSA_c28330	COG5002	protein histidine kinase activity
CLSA_c28350	COG0460	homoserine dehydrogenase
CLSA_c28370	COG1132	(ABC) transporter
CLSA_c28380	COG1404	Belongs to the peptidase S8 family
CLSA_c28450	COG0489	protein tyrosine kinase activity
CLSA_c28480	COG1091	dTDP-4-dehydrorhamnose reductase activity
CLSA_c28610	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
CLSA_c28640	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
CLSA_c28660	COG0635	Involved in the biosynthesis of porphyrin-containing compound
CLSA_c28670	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CLSA_c28680	COG1490	D-aminoacyl-tRNA deacylase activity
CLSA_c28690	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CLSA_c28700	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
CLSA_c28710	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
CLSA_c28710	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
CLSA_c28720	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CLSA_c28730	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CLSA_c28760	COG0343	queuine tRNA-ribosyltransferase activity
CLSA_c28770	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
CLSA_c28780	COG2255	four-way junction helicase activity
CLSA_c28790	COG0632	four-way junction helicase activity
CLSA_c28830	COG0583	DNA-binding transcription factor activity
CLSA_c28840	COG0281	malic enzyme
CLSA_c28850	COG0471	metal ion transport
CLSA_c28860	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
CLSA_c28900	COG0671	phosphoesterase, PA-phosphatase related
CLSA_c28910	COG5002	protein histidine kinase activity
CLSA_c28920	COG0745	RESPONSE REGULATOR receiver
CLSA_c28930	COG5577	PFAM Coat F domain
CLSA_c28950	COG1063	alcohol dehydrogenase
CLSA_c28960	COG5577	PFAM Coat F domain
CLSA_c28980	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
CLSA_c29340	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
CLSA_c29470	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
CLSA_c29720	COG5492	domain, Protein
CLSA_c29730	COG1045	serine acetyltransferase
CLSA_c29780	COG3299	homolog of phage Mu protein gp47
CLSA_c29810	COG0791	NLP P60 protein
CLSA_c30050	COG2189	Belongs to the N(4) N(6)-methyltransferase family
CLSA_c30150	COG0037	tRNA processing
CLSA_c30250	COG2002	toxin-antitoxin pair type II binding
CLSA_c30310	COG1396	sequence-specific DNA binding
CLSA_c30320	COG4974	Belongs to the 'phage' integrase family
CLSA_c30400	COG1595	DNA-templated transcription, initiation
CLSA_c30420	COG0723	plastoquinol--plastocyanin reductase activity
CLSA_c30420	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
CLSA_c30430	COG0024	Methionine aminopeptidase
CLSA_c30440	COG1395	domain, Protein
CLSA_c30450	COG2006	4fe-4S ferredoxin, iron-sulfur binding domain protein
CLSA_c30460	COG1253	flavin adenine dinucleotide binding
CLSA_c30470	COG0501	Belongs to the peptidase M48B family
CLSA_c30520	COG0647	UMP catabolic process
CLSA_c30550	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
CLSA_c30560	COG1592	Rubrerythrin
CLSA_c30560	COG1773	rubredoxin
CLSA_c30580	COG0484	heat shock protein binding
CLSA_c30620	COG0531	amino acid
CLSA_c30640	COG1362	aminopeptidase activity
CLSA_c30650	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
CLSA_c30720	COG0646	methionine synthase
CLSA_c30720	COG1410	methionine synthase
CLSA_c30750	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
CLSA_c30800	COG1527	subunit (C
CLSA_c30820	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CLSA_c30830	COG1269	ATP hydrolysis coupled proton transport
CLSA_c30850	COG0439	Biotin carboxylase
CLSA_c30860	COG0511	ligase activity, forming carbon-carbon bonds
CLSA_c30870	COG1984	allophanate hydrolase subunit 2
CLSA_c30880	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
CLSA_c30900	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
CLSA_c30910	COG4336	lyase activity
CLSA_c30950	COG1522	sequence-specific DNA binding
CLSA_c30980	COG0038	chloride channel
CLSA_c30990	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
CLSA_c31030	COG2244	polysaccharide biosynthetic process
CLSA_c31040	COG0564	pseudouridine synthase activity
CLSA_c31060	COG0849	cell division
CLSA_c31090	COG0210	DNA helicase
CLSA_c31100	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
CLSA_c31140	COG0735	belongs to the Fur family
CLSA_c31200	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
CLSA_c31210	COG1067	ATP-dependent peptidase activity
CLSA_c31210	COG0470	DNA polymerase III
CLSA_c31220	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
CLSA_c31240	COG0544	peptidyl-prolyl cis-trans isomerase activity
CLSA_c31270	COG0140	phosphoribosyl-ATP diphosphatase activity
CLSA_c31280	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
CLSA_c31290	COG0107	imidazoleglycerol-phosphate synthase activity
CLSA_c31300	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
CLSA_c31310	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
CLSA_c31320	COG0131	Imidazoleglycerol-phosphate dehydratase
CLSA_c31330	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CLSA_c31340	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
CLSA_c31450	COG1595	DNA-templated transcription, initiation
CLSA_c31460	COG1301	dicarboxylic acid transport
CLSA_c31470	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CLSA_c31500	COG4492	Belongs to the UPF0735 family
CLSA_c31510	COG0083	homoserine kinase activity
CLSA_c31520	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
CLSA_c31560	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
CLSA_c31580	COG1376	ErfK ybiS ycfS ynhG family protein
CLSA_c31590	COG5002	protein histidine kinase activity
CLSA_c31590	COG3850	Histidine kinase
CLSA_c31640	COG0039	L-malate dehydrogenase activity
CLSA_c31650	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
CLSA_c31660	COG0113	porphobilinogen synthase activity
CLSA_c31680	COG0181	hydroxymethylbilane synthase activity
CLSA_c31700	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
CLSA_c31850	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
CLSA_c31870	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
CLSA_c31880	COG2706	6-phosphogluconolactonase activity
CLSA_c31890	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
CLSA_c31910	COG0561	phosphatase activity
CLSA_c31920	COG0673	inositol 2-dehydrogenase activity
CLSA_c31960	COG1492	cobalamin metabolic process
CLSA_c31970	COG0482	sulfurtransferase activity
CLSA_c31980	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
CLSA_c32020	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
CLSA_c32050	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
CLSA_c32090	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
CLSA_c32130	COG1705	Flagellar rod assembly protein muramidase FlgJ
CLSA_c32140	COG2099	Precorrin-6x reductase
CLSA_c32180	COG4565	transcriptional regulatory protein
CLSA_c32190	COG3290	protein histidine kinase activity
CLSA_c32200	COG3426	butyrate kinase activity
CLSA_c32220	COG0281	malic enzyme
CLSA_c32260	COG2078	PFAM AMMECR1 domain protein
CLSA_c32260	COG3885	ferrous iron binding
CLSA_c32300	COG3158	transport of potassium into the cell
CLSA_c32370	COG5002	protein histidine kinase activity
CLSA_c32380	COG0745	RESPONSE REGULATOR receiver
CLSA_c32400	COG1704	LemA family
CLSA_c32420	COG0598	Magnesium transport protein CorA
CLSA_c32440	COG2875	Belongs to the precorrin methyltransferase family
CLSA_c32470	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CLSA_c32470	COG1648	precorrin-2 dehydrogenase activity
CLSA_c32480	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
CLSA_c32530	COG3706	GGDEF domain
CLSA_c32530	COG0745	RESPONSE REGULATOR receiver
CLSA_c32570	COG0428	transporter
CLSA_c32650	COG5002	protein histidine kinase activity
CLSA_c32690	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CLSA_c32700	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CLSA_c32710	COG4604	ABC transporter, ATP-binding protein
CLSA_c32720	COG3328	transposase activity
CLSA_c32730	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
CLSA_c32740	COG0583	DNA-binding transcription factor activity
CLSA_c32760	COG0310	cobalt ion transport
CLSA_c32770	COG1122	ATPase activity
CLSA_c32790	COG1228	amidohydrolase
CLSA_c32870	COG3279	Response regulator of the LytR AlgR family
CLSA_c32890	COG4864	UPF0365 protein
CLSA_c32920	COG0583	DNA-binding transcription factor activity
CLSA_c32930	COG0697	spore germination
CLSA_c32970	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
CLSA_c32990	COG1940	carbohydrate kinase activity
CLSA_c33020	COG2323	membrane
CLSA_c33050	COG2323	membrane
CLSA_c33070	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CLSA_c33110	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CLSA_c33130	COG1879	ABC-type sugar transport system periplasmic component
CLSA_c33180	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
CLSA_c33190	COG1253	flavin adenine dinucleotide binding
CLSA_c33200	COG0347	Belongs to the P(II) protein family
CLSA_c33230	COG4177	L-phenylalanine transmembrane transporter activity
CLSA_c33240	COG0559	Belongs to the binding-protein-dependent transport system permease family
CLSA_c33290	COG0559	Belongs to the binding-protein-dependent transport system permease family
CLSA_c33370	COG2323	membrane
CLSA_c33450	COG1396	sequence-specific DNA binding
CLSA_c33460	COG0697	spore germination
CLSA_c33480	COG1136	(ABC) transporter
CLSA_c33490	COG0598	Magnesium transport protein CorA
CLSA_c33530	COG3104	oligopeptide transport
CLSA_c33550	COG0706	membrane insertase activity
CLSA_c33560	COG1742	UPF0060 membrane protein
CLSA_c33590	COG2249	NAD(P)H dehydrogenase (quinone) activity
CLSA_c33610	COG4689	acetoacetate decarboxylase
CLSA_c33640	COG1012	belongs to the aldehyde dehydrogenase family
CLSA_c33680	COG3850	Histidine kinase
CLSA_c33680	COG5002	protein histidine kinase activity
CLSA_c33690	COG0745	RESPONSE REGULATOR receiver
CLSA_c33700	COG1114	Component of the transport system for branched-chain amino acids
CLSA_c33800	COG1011	Hydrolase
CLSA_c33860	COG1131	(ABC) transporter
CLSA_c33870	COG1725	Transcriptional regulator
CLSA_c33920	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
CLSA_c33930	COG2733	membrane
CLSA_c33970	COG2217	Heavy metal translocating P-type atpase
CLSA_c33980	COG3328	transposase activity
CLSA_c34020	COG3290	protein histidine kinase activity
CLSA_c34020	COG0840	transmembrane signaling receptor activity
CLSA_c34090	COG0840	transmembrane signaling receptor activity
CLSA_c34160	COG1309	transcriptional regulator
CLSA_c34180	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
CLSA_c34210	COG3647	Membrane
CLSA_c34240	COG1028	Short-chain dehydrogenase reductase Sdr
CLSA_c34390	COG0454	-acetyltransferase
CLSA_c34420	COG0477	Major facilitator Superfamily
CLSA_c34450	COG0789	Transcriptional regulator
CLSA_c34470	COG0406	alpha-ribazole phosphatase activity
CLSA_c34520	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
CLSA_c34590	COG0346	lactoylglutathione lyase activity
CLSA_c34690	COG0726	polysaccharide deacetylase
CLSA_c34690	COG1649	PFAM Uncharacterised BCR, COG1649
CLSA_c34780	COG0281	malic enzyme
CLSA_c34790	COG0493	'glutamate synthase
CLSA_c34800	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
CLSA_c34810	COG2985	domain, Protein
CLSA_c34810	COG0569	domain protein
CLSA_c34820	COG2828	Protein conserved in bacteria
CLSA_c34830	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
CLSA_c34850	COG3051	citrate lyase alpha subunit
CLSA_c34870	COG3052	prosthetic group binding
CLSA_c34880	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
CLSA_c34890	COG1802	Transcriptional regulator
CLSA_c34910	COG1113	amino acid transport
CLSA_c34980	COG0662	Cupin 2, conserved barrel domain protein
CLSA_c34990	COG0840	transmembrane signaling receptor activity
CLSA_c35020	COG0534	Mate efflux family protein
CLSA_c35080	COG0840	transmembrane signaling receptor activity
CLSA_c35080	COG3290	protein histidine kinase activity
CLSA_c35140	COG2801	Transposase and inactivated derivatives
CLSA_c35210	COG5444	nuclease activity
CLSA_c35310	COG0840	transmembrane signaling receptor activity
CLSA_c35310	COG5278	phosphoserine phosphatase activity
CLSA_c35330	COG0840	transmembrane signaling receptor activity
CLSA_c35410	COG3299	homolog of phage Mu protein gp47
CLSA_c35620	COG3728	DNA packaging
CLSA_c35620	COG5484	DNA packaging
CLSA_c35690	COG1484	DNA-dependent DNA replication
CLSA_c35760	COG2801	Transposase and inactivated derivatives
CLSA_c35780	COG1131	(ABC) transporter
CLSA_c35810	COG0840	transmembrane signaling receptor activity
CLSA_c35840	COG2207	Transcriptional regulator
CLSA_c35860	COG0789	Transcriptional regulator
CLSA_c35870	COG5504	Zn-dependent protease
CLSA_c35910	COG3866	Pectate lyase
CLSA_c35920	COG1335	isochorismatase
CLSA_c35930	COG1522	sequence-specific DNA binding
CLSA_c35940	COG0583	DNA-binding transcription factor activity
CLSA_c35950	COG1881	PFAM PEBP family protein
CLSA_c35960	COG0138	bifunctional purine biosynthesis protein purh
CLSA_c35970	COG2076	Multidrug Resistance protein
CLSA_c36050	COG0745	RESPONSE REGULATOR receiver
CLSA_c36060	COG5002	protein histidine kinase activity
CLSA_c36110	COG2723	6-phospho-beta-galactosidase activity
CLSA_c36140	COG1454	alcohol dehydrogenase
CLSA_c36190	COG3576	pyridoxamine 5-phosphate
CLSA_c36270	COG0583	DNA-binding transcription factor activity
CLSA_c36280	COG2855	membrane
CLSA_c36300	COG5002	protein histidine kinase activity
CLSA_c36310	COG0745	RESPONSE REGULATOR receiver
CLSA_c36320	COG1216	Glycosyl transferase, family 2
CLSA_c36360	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
CLSA_c36380	COG0693	protein deglycase activity
CLSA_c36390	COG4753	response regulator
CLSA_c36390	COG2207	Transcriptional regulator
CLSA_c36440	COG1172	Belongs to the binding-protein-dependent transport system permease family
CLSA_c36450	COG1129	ABC transporter
CLSA_c36500	COG5444	nuclease activity
CLSA_c36540	COG3547	Transposase (IS116 IS110 IS902 family)
CLSA_c36750	COG1472	Belongs to the glycosyl hydrolase 3 family
CLSA_c36770	COG0840	transmembrane signaling receptor activity
CLSA_c36780	COG4753	response regulator
CLSA_c36780	COG2207	Transcriptional regulator
CLSA_c36790	COG4251	negative regulation of phosphorylation
CLSA_c36810	COG5002	protein histidine kinase activity
CLSA_c36870	COG0726	polysaccharide deacetylase
CLSA_c36880	COG1132	(ABC) transporter
CLSA_c36890	COG1132	(ABC) transporter
CLSA_c36900	COG0583	DNA-binding transcription factor activity
CLSA_c36910	COG3655	Transcriptional regulator
CLSA_c36940	COG3760	aminoacyl-tRNA metabolism involved in translational fidelity
CLSA_c36960	COG1733	regulation of RNA biosynthetic process
CLSA_c36980	COG0842	Transport permease protein
CLSA_c36990	COG1131	(ABC) transporter
CLSA_c37020	COG3300	MHYT domain
CLSA_c37020	COG5001	Diguanylate cyclase
CLSA_c37060	COG1132	(ABC) transporter
CLSA_c37100	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
CLSA_c37160	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
CLSA_c37220	COG2340	Cysteine-rich secretory protein family
CLSA_c37240	COG1879	ABC-type sugar transport system periplasmic component
CLSA_c37270	COG1595	DNA-templated transcription, initiation
CLSA_c37300	COG0840	transmembrane signaling receptor activity
CLSA_c37370	COG1879	ABC-type sugar transport system periplasmic component
CLSA_c37410	COG2816	NAD+ diphosphatase activity
CLSA_c37420	COG0840	transmembrane signaling receptor activity
CLSA_c37490	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
CLSA_c37500	COG1846	Transcriptional regulator
CLSA_c37510	COG2814	Major facilitator Superfamily
CLSA_c37530	COG0477	Major facilitator Superfamily
CLSA_c37550	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CLSA_c37560	COG0745	RESPONSE REGULATOR receiver
CLSA_c37570	COG5002	protein histidine kinase activity
CLSA_c37580	COG5599	Phosphatase
CLSA_c37630	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CLSA_c37680	COG1846	Transcriptional regulator
CLSA_c37690	COG4106	trans-aconitate 2-methyltransferase activity
CLSA_c37770	COG0386	Belongs to the glutathione peroxidase family
CLSA_c37790	COG0531	amino acid
CLSA_c37860	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CLSA_c37880	COG0583	DNA-binding transcription factor activity
CLSA_c38000	COG1151	hydroxylamine reductase activity
CLSA_c38040	COG0754	glutathionylspermidine amidase activity
CLSA_c38130	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
CLSA_c38150	COG2824	Alkylphosphonate utilization operon protein PhnA
CLSA_c38160	COG0726	polysaccharide deacetylase
CLSA_c38170	COG5002	protein histidine kinase activity
CLSA_c38190	COG0463	Glycosyl transferase, family 2
CLSA_c38200	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
CLSA_c38210	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
CLSA_c38220	COG0861	Integral membrane protein TerC family
CLSA_c38230	COG4302	ethanolamine ammonia-lyase activity
CLSA_c38240	COG4303	Ethanolamine ammonia lyase large subunit
CLSA_c38260	COG4819	ethanolamine utilization protein
CLSA_c38280	COG0840	transmembrane signaling receptor activity
CLSA_c38310	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CLSA_c38360	COG3958	Transketolase
CLSA_c38370	COG3959	Transketolase, thiamine diphosphate binding domain
CLSA_c38420	COG3037	sugar-specific permease SgaT UlaA
CLSA_c38460	COG1349	DNA-binding transcription factor activity
CLSA_c38470	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
CLSA_c38480	COG2033	superoxide reductase activity
CLSA_c38500	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CLSA_c38530	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
CLSA_c38550	COG1523	belongs to the glycosyl hydrolase 13 family
CLSA_c38570	COG4086	secreted protein
CLSA_c38610	COG2267	carboxylic ester hydrolase activity
CLSA_c38660	COG0813	purine-nucleoside phosphorylase activity
CLSA_c38710	COG1744	ABC transporter substrate-binding protein PnrA-like
CLSA_c38730	COG0436	Aminotransferase
CLSA_c38740	COG1522	sequence-specific DNA binding
CLSA_c38760	COG0542	response to heat
CLSA_c38770	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
CLSA_c38780	COG1982	Orn Lys Arg decarboxylase major
CLSA_c38800	COG0612	Peptidase, M16
CLSA_c38840	COG0326	Molecular chaperone. Has ATPase activity
CLSA_c38850	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
CLSA_c38850	COG2199	diguanylate cyclase activity
CLSA_c38870	COG1136	(ABC) transporter
CLSA_c38890	COG2205	protein histidine kinase activity
CLSA_c38900	COG0745	RESPONSE REGULATOR receiver
CLSA_c38910	COG0840	transmembrane signaling receptor activity
CLSA_c38930	COG0175	sulfate reduction
CLSA_c38960	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
CLSA_c38970	COG4208	sulfate ABC transporter
CLSA_c38990	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
CLSA_c39040	COG0726	polysaccharide deacetylase
CLSA_c39080	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
CLSA_c39110	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
CLSA_c39130	COG4786	Flagellar basal body rod
CLSA_c39170	COG1191	sigma factor activity
CLSA_c39190	COG0455	bacterial-type flagellum organization
CLSA_c39200	COG1419	protein localization to endoplasmic reticulum
CLSA_c39210	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CLSA_c39220	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CLSA_c39240	COG1338	Plays a role in the flagellum-specific transport system
CLSA_c39270	COG1582	Flagellar protein (FlbD)
CLSA_c39280	COG4786	Flagellar basal body rod
CLSA_c39320	COG2882	bacterial-type flagellum organization
CLSA_c39330	COG1157	protein secretion by the type III secretion system
CLSA_c39350	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CLSA_c39360	COG1766	The M ring may be actively involved in energy transduction
CLSA_c39370	COG1677	Flagellar hook-basal body complex protein FliE
CLSA_c39380	COG1558	bacterial-type flagellum-dependent cell motility
CLSA_c39390	COG1815	bacterial-type flagellum-dependent cell motility
CLSA_c39450	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
CLSA_c39460	COG1088	dTDP-glucose 4,6-dehydratase activity
CLSA_c39480	COG1086	Polysaccharide biosynthesis protein
CLSA_c39490	COG0457	Tetratricopeptide repeat
CLSA_c39490	COG0463	Glycosyl transferase, family 2
CLSA_c39500	COG2089	acid synthase
CLSA_c39520	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
CLSA_c39540	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
CLSA_c39570	COG0107	imidazoleglycerol-phosphate synthase activity
CLSA_c39580	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
CLSA_c39600	COG1861	Spore coat polysaccharide biosynthesis protein F CMP-KDO synthetase
CLSA_c39650	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
CLSA_c39680	COG1334	flagellar protein FlaG
CLSA_c39690	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
CLSA_c39700	COG1699	Binds to the C-terminal region of flagellin, which is implicated in polymerization, and participates in the assembly of the flagellum
CLSA_c39720	COG1256	bacterial-type flagellum assembly
CLSA_c39720	COG4786	Flagellar basal body rod
CLSA_c39750	COG1776	CheC inhibitor of MCP methylation
CLSA_c39750	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CLSA_c39760	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
CLSA_c39780	COG2201	protein-glutamate methylesterase activity
CLSA_c39790	COG1776	CheC inhibitor of MCP methylation
CLSA_c39800	COG2198	Histidine kinase
CLSA_c39800	COG0643	Histidine kinase
CLSA_c39810	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
CLSA_c39820	COG2201	protein-glutamate methylesterase activity
CLSA_c39880	COG0436	Aminotransferase
CLSA_c39910	COG0655	NAD(P)H dehydrogenase (quinone) activity
CLSA_c39920	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CLSA_c39930	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
CLSA_c39930	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
CLSA_c39950	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CLSA_c39960	COG0187	DNA topoisomerase II activity
CLSA_c39970	COG1215	transferase activity, transferring glycosyl groups
CLSA_c39990	COG0457	Tetratricopeptide repeat
CLSA_c39990	COG0705	Rhomboid family
CLSA_c40000	COG1164	Oligoendopeptidase f
CLSA_c40030	COG1121	(ABC) transporter
CLSA_c40040	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CLSA_c40060	COG1971	Probably functions as a manganese efflux pump
CLSA_c40070	COG0205	6-phosphofructokinase activity
CLSA_c40080	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CLSA_c40100	COG1309	transcriptional regulator
CLSA_c40110	COG0488	(ABC) transporter
CLSA_c40120	COG0756	dUTP diphosphatase activity
CLSA_c40140	COG0726	polysaccharide deacetylase
CLSA_c40180	COG0037	tRNA processing
CLSA_c40200	COG3191	aminopeptidase activity
CLSA_c40280	COG0437	4 iron, 4 sulfur cluster binding
CLSA_c40290	COG0243	molybdopterin cofactor binding
CLSA_c40310	COG1464	Belongs to the NlpA lipoprotein family
CLSA_c40320	COG2011	ABC-type metal ion transport system permease component
CLSA_c40340	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
CLSA_c40350	COG0557	exoribonuclease II activity
CLSA_c40370	COG0148	phosphopyruvate hydratase activity
CLSA_c40400	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
CLSA_c40410	COG0149	triose-phosphate isomerase activity
CLSA_c40420	COG0126	phosphoglycerate kinase activity
CLSA_c40440	COG2390	Transcriptional regulator
CLSA_c40450	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
CLSA_c40470	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
CLSA_c40480	COG2720	vancomycin resistance protein
CLSA_c40500	COG1181	Belongs to the D-alanine--D-alanine ligase family
CLSA_c40520	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
CLSA_c40540	COG1045	serine acetyltransferase
CLSA_c40550	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CLSA_c40560	COG2239	Acts as a magnesium transporter
CLSA_c40600	COG1597	lipid kinase activity
CLSA_c40610	COG1183	phosphatidylcholine synthase activity
CLSA_c40640	COG1592	Rubrerythrin
CLSA_c40650	COG2719	SpoVR family
CLSA_c40660	COG2718	Belongs to the UPF0229 family
CLSA_c40670	COG2766	serine protein kinase
CLSA_c40680	COG2814	Major facilitator Superfamily
CLSA_c40700	COG2201	protein-glutamate methylesterase activity
CLSA_c40710	COG0390	transport system, permease component
CLSA_c40720	COG2274	protein secretion by the type I secretion system
CLSA_c40730	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
CLSA_c40740	COG0493	'glutamate synthase
CLSA_c40740	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
CLSA_c40760	COG1063	alcohol dehydrogenase
CLSA_c40820	COG2205	protein histidine kinase activity
CLSA_c40830	COG0745	RESPONSE REGULATOR receiver
CLSA_c40850	COG2199	diguanylate cyclase activity
CLSA_c40850	COG2200	EAL domain
CLSA_c40850	COG2202	Pas domain
CLSA_c40860	COG4974	Belongs to the 'phage' integrase family
CLSA_c40880	COG1846	Transcriptional regulator
CLSA_c40890	COG1960	acyl-CoA dehydrogenase activity
CLSA_c40900	COG4670	ketone body catabolic process
CLSA_c40910	COG1024	Enoyl-CoA hydratase
CLSA_c40920	COG0495	leucyl-tRNA aminoacylation
CLSA_c40940	COG3279	Response regulator of the LytR AlgR family
CLSA_c40950	COG2205	protein histidine kinase activity
CLSA_c41010	COG2357	RelA SpoT domain protein
CLSA_c41030	COG0840	transmembrane signaling receptor activity
CLSA_c41080	COG2723	6-phospho-beta-galactosidase activity
CLSA_c41090	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CLSA_c41090	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
CLSA_c41120	COG0698	ribose 5-phosphate isomerase
CLSA_c41130	COG1349	DNA-binding transcription factor activity
CLSA_c41150	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
CLSA_c41170	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
CLSA_c41200	COG2199	diguanylate cyclase activity
CLSA_c41200	COG2203	Gaf domain
CLSA_c41230	COG1210	Utp--glucose-1-phosphate uridylyltransferase
CLSA_c41240	COG0673	inositol 2-dehydrogenase activity
CLSA_c41250	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
CLSA_c41300	COG1216	Glycosyl transferase, family 2
CLSA_c41300	COG1442	glycosyl transferase family 8
CLSA_c41310	COG3475	LICD family
CLSA_c41320	COG1442	glycosyl transferase family 8
CLSA_c41320	COG1216	Glycosyl transferase, family 2
CLSA_c41330	COG0860	N-Acetylmuramoyl-L-alanine amidase
CLSA_c41370	COG1737	Transcriptional regulator
CLSA_c41400	COG2723	6-phospho-beta-galactosidase activity
CLSA_c41410	COG0561	phosphatase activity
CLSA_c41420	COG3706	GGDEF domain
CLSA_c41430	COG0697	spore germination
CLSA_c41450	COG0697	spore germination
CLSA_c41480	COG4750	Nucleotidyl transferase
CLSA_c41540	COG1737	Transcriptional regulator
CLSA_c41550	COG1737	Transcriptional regulator
CLSA_c41580	COG1486	melibiose metabolic process
CLSA_c41610	COG1263	PTS System
CLSA_c41610	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CLSA_c41620	COG2190	(PTS) system
CLSA_c41640	COG0463	Glycosyl transferase, family 2
CLSA_c41640	COG0457	Tetratricopeptide repeat
CLSA_c41690	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
CLSA_c41740	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
CLSA_c41800	COG1231	oxidoreductase activity
CLSA_c41810	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
CLSA_c41840	COG0584	glycerophosphoryl diester phosphodiesterase
CLSA_c41990	COG0463	Glycosyl transferase, family 2
CLSA_c42010	COG1442	glycosyl transferase family 8
CLSA_c42010	COG1216	Glycosyl transferase, family 2
CLSA_c42040	COG1682	transport, permease protein
CLSA_c42060	COG1216	Glycosyl transferase, family 2
CLSA_c42080	COG0438	transferase activity, transferring glycosyl groups
CLSA_c42150	COG0577	efflux transmembrane transporter activity
CLSA_c42150	COG1136	(ABC) transporter
CLSA_c42220	COG1210	Utp--glucose-1-phosphate uridylyltransferase
CLSA_c42240	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CLSA_c42260	COG1091	dTDP-4-dehydrorhamnose reductase activity
CLSA_c42280	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
CLSA_c42350	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
CLSA_c42370	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
CLSA_c42410	COG0489	protein tyrosine kinase activity
CLSA_c42420	COG3944	biosynthesis protein
CLSA_c42480	COG0840	transmembrane signaling receptor activity
CLSA_c42500	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
CLSA_c42510	COG0840	transmembrane signaling receptor activity
CLSA_c42520	COG0561	phosphatase activity
CLSA_c42530	COG1349	DNA-binding transcription factor activity
CLSA_c42540	COG0840	transmembrane signaling receptor activity
CLSA_c42550	COG3459	Glycosyltransferase 36 associated
CLSA_c42560	COG1362	aminopeptidase activity
CLSA_c42580	COG0840	transmembrane signaling receptor activity
CLSA_c42600	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CLSA_c42610	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
CLSA_c42620	COG3590	peptidase
CLSA_c42630	COG1126	abc transporter atp-binding protein
CLSA_c42640	COG0765	amino acid transport
CLSA_c42650	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CLSA_c42670	COG3973	AAA domain
CLSA_c42680	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CLSA_c42700	COG0681	Belongs to the peptidase S26 family
CLSA_c42720	COG0019	diaminopimelate decarboxylase activity
CLSA_c42760	COG3328	transposase activity
CLSA_c42770	COG0840	transmembrane signaling receptor activity
CLSA_c42780	COG2608	mercury ion transmembrane transporter activity
CLSA_c42790	COG2217	Heavy metal translocating P-type atpase
CLSA_c42800	COG1937	Protein conserved in bacteria
CLSA_c42810	COG1408	metallophosphoesterase
CLSA_c42840	COG1266	CAAX protease self-immunity
CLSA_c42880	COG0628	permease
CLSA_c42900	COG0469	pyruvate kinase activity
CLSA_c42940	COG1481	regulation of sporulation
CLSA_c42950	COG0391	Required for morphogenesis under gluconeogenic growth conditions
CLSA_c42960	COG1660	Displays ATPase and GTPase activities
CLSA_c42970	COG0812	UDP-N-acetylmuramate dehydrogenase activity
CLSA_c42990	COG0322	excinuclease ABC activity
CLSA_c43000	COG0768	penicillin binding
CLSA_c43020	COG1716	ATPase activity
CLSA_c43040	COG0556	nucleotide-excision repair
CLSA_c43050	COG0833	amino acid
CLSA_c43070	COG3409	Peptidoglycan-binding domain 1 protein
CLSA_c43070	COG0793	Belongs to the peptidase S41A family
CLSA_c43080	COG2177	Part of the ABC transporter FtsEX involved in
CLSA_c43090	COG2884	Cell division ATP-binding protein ftsE
CLSA_c43100	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
CLSA_c43110	COG3958	Transketolase
CLSA_c43120	COG3959	Transketolase, thiamine diphosphate binding domain
CLSA_c43130	COG2337	Toxic component of a toxin-antitoxin (TA) module
CLSA_c43170	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
CLSA_c43170	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
CLSA_c43180	COG0736	holo-[acyl-carrier-protein] synthase activity
CLSA_c43200	COG0629	single-stranded DNA binding
CLSA_c43210	COG1295	ribonuclease BN
CLSA_c43220	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
CLSA_c43230	COG1696	Membrane protein involved in D-alanine export
CLSA_c43320	COG2002	toxin-antitoxin pair type II binding
CLSA_c43330	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
CLSA_c43340	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
CLSA_c43370	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CLSA_c43380	COG3328	transposase activity
CLSA_c43400	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
CLSA_c43470	COG1546	Belongs to the CinA family
CLSA_c43470	COG1058	Belongs to the CinA family
CLSA_c43480	COG1940	carbohydrate kinase activity
CLSA_c43510	COG2801	Transposase and inactivated derivatives
CLSA_c43520	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
CLSA_c43540	COG1368	sulfuric ester hydrolase activity
CLSA_c43680	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
CLSA_c43720	COG0039	L-malate dehydrogenase activity
CLSA_c43770	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
CLSA_c43780	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
CLSA_c43800	COG0058	SHG alpha-glucan phosphorylase activity
CLSA_c43810	COG0297	glycogen (starch) synthase activity
CLSA_c43820	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
CLSA_c43880	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CLSA_c43880	COG1263	PTS System
CLSA_c43880	COG2190	(PTS) system
CLSA_c43890	COG3711	transcriptional antiterminator
CLSA_c43910	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
CLSA_c43930	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
CLSA_c43970	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
CLSA_c43980	COG4166	transmembrane transport
CLSA_c43990	COG4608	Belongs to the ABC transporter superfamily
CLSA_c44000	COG0444	Belongs to the ABC transporter superfamily
CLSA_c44010	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CLSA_c44020	COG0601	transmembrane transport
CLSA_c44040	COG3590	peptidase
CLSA_c44100	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
CLSA_c44120	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
CLSA_c44140	COG1733	regulation of RNA biosynthetic process
CLSA_c44180	COG1914	H( )-stimulated, divalent metal cation uptake system
CLSA_c44190	COG2239	Acts as a magnesium transporter
CLSA_c44200	COG0772	Belongs to the SEDS family
CLSA_c44240	COG0590	tRNA wobble adenosine to inosine editing
CLSA_c44250	COG1253	flavin adenine dinucleotide binding
CLSA_c44270	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CLSA_c44280	COG1621	beta-fructofuranosidase activity
CLSA_c44290	COG1609	Transcriptional regulator
CLSA_c44310	COG3620	sequence-specific DNA binding
CLSA_c44320	COG1132	(ABC) transporter
CLSA_c44330	COG1132	(ABC) transporter
CLSA_c44350	COG2814	Major facilitator Superfamily
CLSA_c44400	COG1619	proteins homologs of microcin C7 resistance protein MccF
CLSA_c44440	COG3290	protein histidine kinase activity
CLSA_c44460	COG4512	PFAM Accessory gene regulator B
CLSA_c44510	COG1131	(ABC) transporter
CLSA_c44640	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
CLSA_c44660	COG0513	Belongs to the DEAD box helicase family
CLSA_c44680	COG3933	PFAM sigma-54 factor interaction domain-containing protein
CLSA_c44680	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
CLSA_c44690	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
CLSA_c44690	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CLSA_c44700	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CLSA_c44700	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
CLSA_c44710	COG0617	tRNA 3'-terminal CCA addition
CLSA_c44720	COG0347	Belongs to the P(II) protein family
CLSA_c44730	COG0004	ammonium transporteR
CLSA_c44760	COG0659	secondary active sulfate transmembrane transporter activity
CLSA_c44780	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CLSA_c44900	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
CLSA_c44910	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
CLSA_c44930	COG0037	tRNA processing
CLSA_c44990	COG0860	N-Acetylmuramoyl-L-alanine amidase
CLSA_c45050	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
CLSA_c45070	COG0840	transmembrane signaling receptor activity
CLSA_c45080	COG0653	protein targeting
CLSA_c45090	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
CLSA_c45140	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
CLSA_c45150	COG1404	Belongs to the peptidase S8 family
CLSA_c45220	COG2081	HI0933 family
CLSA_c45260	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
CLSA_c45270	COG0305	Participates in initiation and elongation during chromosome replication
CLSA_c45280	COG0470	DNA polymerase III
CLSA_c45280	COG1067	ATP-dependent peptidase activity
CLSA_c45290	COG0359	binds to the 23S rRNA
CLSA_c45300	COG3887	signaling protein consisting of a modified GGDEF domain and a DHH domain
CLSA_c45320	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
CLSA_c45330	COG0629	single-stranded DNA binding
CLSA_c45340	COG0360	Binds together with S18 to 16S ribosomal RNA
CLSA_c45360	COG0668	transmembrane transport
CLSA_c45420	COG1475	DNA binding
CLSA_c45430	COG1192	Involved in chromosome partitioning
CLSA_c45450	COG0357	Ribosomal RNA small subunit methyltransferase G
CLSA_c45460	COG0445	tRNA wobble uridine modification
CLSA_c45470	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
CLSA_c45480	COG1847	R3H domain protein
CLSA_c45500	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
CLSA_c45510	COG0594	ribonuclease P activity
CLSA_c45520	COG0230	Belongs to the bacterial ribosomal protein bL34 family