locus-tag	class	description
I6I67_00025	COG1846	Transcriptional regulator
I6I67_00030	COG0135	phosphoribosylanthranilate isomerase activity
I6I67_00035	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
I6I67_00040	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I6I67_00050	COG2313	pseudouridylate synthase activity
I6I67_00055	COG0697	spore germination
I6I67_00065	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6I67_00150	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
I6I67_00155	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
I6I67_00165	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
I6I67_00185	COG1119	ATPase activity
I6I67_00190	COG0366	Alpha amylase catalytic
I6I67_00200	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I6I67_00205	COG0747	negative chemotaxis
I6I67_00220	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
I6I67_00230	COG0355	proton-transporting ATP synthase activity, rotational mechanism
I6I67_00235	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
I6I67_00240	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
I6I67_00245	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
I6I67_00250	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
I6I67_00255	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
I6I67_00260	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
I6I67_00265	COG0356	it plays a direct role in the translocation of protons across the membrane
I6I67_00275	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I6I67_00290	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
I6I67_00315	COG0315	cyclic pyranopterin monophosphate synthase activity
I6I67_00320	COG0746	molybdenum cofactor guanylyltransferase activity
I6I67_00340	COG0725	ABC transporter, periplasmic molybdate-binding protein
I6I67_00355	COG0083	homoserine kinase activity
I6I67_00360	COG0460	homoserine dehydrogenase
I6I67_00365	COG0019	diaminopimelate decarboxylase activity
I6I67_00370	COG0018	arginyl-trna synthetase
I6I67_00375	COG1620	l-lactate permease
I6I67_00390	COG0247	lactate metabolic process
I6I67_00395	COG1139	Iron-sulfur cluster binding protein
I6I67_00400	COG1556	Lactate utilization protein
I6I67_00440	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
I6I67_00450	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
I6I67_00455	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6I67_00475	COG1228	amidohydrolase
I6I67_00480	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
I6I67_00490	COG2986	histidine ammonia-lyase
I6I67_00500	COG3314	Sporulation integral membrane protein YlbJ
I6I67_00510	COG0010	Belongs to the arginase family
I6I67_00515	COG0494	nUDIX hydrolase
I6I67_00525	COG2814	Major facilitator Superfamily
I6I67_00550	COG2272	Belongs to the type-B carboxylesterase lipase family
I6I67_00560	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6I67_00560	COG0567	Dehydrogenase, E1 component
I6I67_00565	COG1484	DNA-dependent DNA replication
I6I67_00610	COG1595	DNA-templated transcription, initiation
I6I67_00620	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
I6I67_00625	COG0297	glycogen (starch) synthase activity
I6I67_00650	COG0463	Glycosyl transferase, family 2
I6I67_00655	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
I6I67_00660	COG1611	Belongs to the LOG family
I6I67_00665	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I6I67_00670	COG1113	amino acid transport
I6I67_00680	COG1113	amino acid transport
I6I67_00705	COG0564	pseudouridine synthase activity
I6I67_00735	COG1217	gtp-binding protein TYPA
I6I67_00750	COG2354	Protein conserved in bacteria
I6I67_00755	COG0428	transporter
I6I67_00770	COG3549	Plasmid maintenance system killer
I6I67_00790	COG0709	Synthesizes selenophosphate from selenide and ATP
I6I67_00800	COG0437	4 iron, 4 sulfur cluster binding
I6I67_00805	COG3383	formate dehydrogenase (NAD+) activity
I6I67_00805	COG0243	molybdopterin cofactor binding
I6I67_00810	COG3383	formate dehydrogenase (NAD+) activity
I6I67_00810	COG0243	molybdopterin cofactor binding
I6I67_00815	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
I6I67_00820	COG0095	Lipoate-protein ligase
I6I67_00825	COG1823	symporter activity
I6I67_00830	COG1484	DNA-dependent DNA replication
I6I67_00845	COG2814	Major facilitator Superfamily
I6I67_00860	COG1012	belongs to the aldehyde dehydrogenase family
I6I67_00870	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
I6I67_00875	COG0693	protein deglycase activity
I6I67_00885	COG0012	GTP binding
I6I67_00895	COG1322	Protein conserved in bacteria
I6I67_00910	COG1570	exodeoxyribonuclease VII activity
I6I67_00915	COG1722	exodeoxyribonuclease VII activity
I6I67_00930	COG1494	fructose-1,6-bisphosphatase
I6I67_00935	COG0114	fumarate hydratase activity
I6I67_00945	COG0477	Major facilitator Superfamily
I6I67_00960	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
I6I67_00985	COG1072	(Pantothenic acid kinase))
I6I67_01000	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
I6I67_01060	COG0148	phosphopyruvate hydratase activity
I6I67_01075	COG3956	TIGRFAM MazG family protein
I6I67_01080	COG0531	amino acid
I6I67_01100	COG2860	membrane
I6I67_01110	COG1518	maintenance of DNA repeat elements
I6I67_01125	COG1857	crispr-associated protein
I6I67_01155	COG2132	Multicopper oxidase
I6I67_01165	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
I6I67_01170	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
I6I67_01180	COG0193	aminoacyl-tRNA hydrolase activity
I6I67_01185	COG0179	Fumarylacetoacetate (FAA) hydrolase
I6I67_01195	COG2326	polyphosphate kinase activity
I6I67_01205	COG2070	2-Nitropropane dioxygenase
I6I67_01210	COG0193	aminoacyl-tRNA hydrolase activity
I6I67_01220	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
I6I67_01225	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I6I67_01230	COG2610	gluconate transmembrane transporter activity
I6I67_01255	COG0123	including yeast histone deacetylase and acetoin utilization protein
I6I67_01265	COG1960	acyl-CoA dehydrogenase activity
I6I67_01275	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I6I67_01290	COG1024	Enoyl-CoA hydratase
I6I67_01295	COG0183	Belongs to the thiolase family
I6I67_01300	COG2985	domain, Protein
I6I67_01300	COG0569	domain protein
I6I67_01330	COG0438	transferase activity, transferring glycosyl groups
I6I67_01345	COG0561	phosphatase activity
I6I67_01350	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
I6I67_01350	COG2755	lipolytic protein G-D-S-L family
I6I67_01370	COG0488	(ABC) transporter
I6I67_01390	COG3583	domain protein
I6I67_01395	COG0084	hydrolase, TatD family'
I6I67_01400	COG0456	acetyltransferase
I6I67_01425	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I6I67_01435	COG1928	C-terminal four TMM region of protein-O-mannosyltransferase
I6I67_01455	COG0519	Catalyzes the synthesis of GMP from XMP
I6I67_01475	COG1210	Utp--glucose-1-phosphate uridylyltransferase
I6I67_01490	COG1970	mechanosensitive ion channel activity
I6I67_01500	COG0315	cyclic pyranopterin monophosphate synthase activity
I6I67_01500	COG0521	Mo-molybdopterin cofactor biosynthetic process
I6I67_01505	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6I67_01525	COG0254	rRNA binding
I6I67_01530	COG0227	Belongs to the bacterial ribosomal protein bL28 family
I6I67_01535	COG0267	Belongs to the bacterial ribosomal protein bL33 family
I6I67_01540	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
I6I67_01590	COG0138	bifunctional purine biosynthesis protein purh
I6I67_01605	COG0739	heme binding
I6I67_01635	COG1605	Chorismate mutase
I6I67_01655	COG3304	Inner membrane component domain
I6I67_01660	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
I6I67_01670	COG1201	RNA secondary structure unwinding
I6I67_01675	COG1218	3'(2'),5'-bisphosphate nucleotidase
I6I67_01680	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
I6I67_01690	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
I6I67_01715	COG1129	ABC transporter
I6I67_01720	COG1132	(ABC) transporter
I6I67_01720	COG2375	cellular response to nickel ion
I6I67_01725	COG1132	(ABC) transporter
I6I67_01770	COG1765	OsmC-like protein
I6I67_01780	COG3757	hydrolase, family 25
I6I67_01790	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6I67_01805	COG0545	Peptidyl-prolyl cis-trans isomerase
I6I67_01810	COG0372	Belongs to the citrate synthase family
I6I67_01830	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6I67_01835	COG2252	PERMEase
I6I67_01860	COG1652	LysM domain
I6I67_01885	COG1061	Type III restriction enzyme res subunit
I6I67_01955	COG4607	ABC-type enterochelin transport system periplasmic component
I6I67_01965	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
I6I67_01975	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6I67_01985	COG0814	amino acid
I6I67_02000	COG2177	Part of the ABC transporter FtsEX involved in
I6I67_02005	COG2884	Cell division ATP-binding protein ftsE
I6I67_02010	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
I6I67_02015	COG0483	inositol monophosphate 1-phosphatase activity
I6I67_02020	COG0483	inositol monophosphate 1-phosphatase activity
I6I67_02045	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6I67_02050	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6I67_02060	COG1120	ATPase activity
I6I67_02095	COG2311	Membrane
I6I67_02100	COG4762	Protein conserved in bacteria
I6I67_02105	COG3878	Protein conserved in bacteria
I6I67_02115	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
I6I67_02140	COG3480	Lon protease (S16) C-terminal proteolytic domain
I6I67_02160	COG0210	DNA helicase
I6I67_02165	COG2816	NAD+ diphosphatase activity
I6I67_02170	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I6I67_02200	COG0513	Belongs to the DEAD box helicase family
I6I67_02220	COG5662	AntiSigma factor
I6I67_02230	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
I6I67_02235	COG2135	peptidase activity
I6I67_02240	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
I6I67_02245	COG1162	GTPase activity
I6I67_02280	COG0653	protein targeting
I6I67_02285	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
I6I67_02295	COG5401	PFAM Sporulation and spore germination
I6I67_02300	COG5002	protein histidine kinase activity
I6I67_02305	COG0745	RESPONSE REGULATOR receiver
I6I67_02325	COG1482	cell wall glycoprotein biosynthetic process
I6I67_02335	COG1648	precorrin-2 dehydrogenase activity
I6I67_02335	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
I6I67_02340	COG0730	response to heat
I6I67_02355	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I6I67_02395	COG1316	TRANSCRIPTIONal
I6I67_02420	COG0028	Belongs to the TPP enzyme family
I6I67_02425	COG0814	amino acid
I6I67_02430	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
I6I67_02435	COG1012	belongs to the aldehyde dehydrogenase family
I6I67_02470	COG2072	flavoprotein involved in K transport
I6I67_02475	COG0657	acetylesterase activity
I6I67_02500	COG3835	regulator
I6I67_02510	COG0659	secondary active sulfate transmembrane transporter activity
I6I67_02515	COG1960	acyl-CoA dehydrogenase activity
I6I67_02530	COG1024	Enoyl-CoA hydratase
I6I67_02535	COG2315	Protein conserved in bacteria
I6I67_02545	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I6I67_02555	COG3835	regulator
I6I67_02580	COG2610	gluconate transmembrane transporter activity
I6I67_02585	COG3265	gluconokinase activity
I6I67_02595	COG2040	homocysteine
I6I67_02600	COG4175	Glycine betaine
I6I67_02600	COG0517	IMP dehydrogenase activity
I6I67_02615	COG2113	Glycine betaine
I6I67_02620	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6I67_02625	COG2186	Transcriptional regulator
I6I67_02640	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6I67_02665	COG2235	arginine
I6I67_02670	COG0814	amino acid
I6I67_02735	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
I6I67_02740	COG1984	allophanate hydrolase subunit 2
I6I67_02745	COG4770	biotin carboxylase activity
I6I67_02755	COG4336	lyase activity
I6I67_02760	COG1914	H( )-stimulated, divalent metal cation uptake system
I6I67_02770	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6I67_02770	COG1024	Enoyl-CoA hydratase
I6I67_02815	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6I67_02830	COG3527	Alpha-acetolactate decarboxylase
I6I67_02840	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
I6I67_02840	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
I6I67_02850	COG3842	ATPase activity
I6I67_02885	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I6I67_02890	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I6I67_02900	COG0424	maF-like protein
I6I67_02915	COG0189	ligase activity
I6I67_02920	COG2897	thiosulfate sulfurtransferase activity
I6I67_02925	COG4770	biotin carboxylase activity
I6I67_02945	COG1484	DNA-dependent DNA replication
I6I67_02950	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
I6I67_02955	COG3547	Transposase (IS116 IS110 IS902 family)
I6I67_02975	COG1136	(ABC) transporter
I6I67_02985	COG0372	Belongs to the citrate synthase family
I6I67_02990	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
I6I67_02995	COG2079	MmgE PrpD family protein
I6I67_03000	COG3800	Transcriptional regulator
I6I67_03000	COG1396	sequence-specific DNA binding
I6I67_03015	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
I6I67_03015	COG1473	amidohydrolase
I6I67_03020	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
I6I67_03045	COG1686	Belongs to the peptidase S11 family
I6I67_03060	COG0180	Tryptophanyl-tRNA synthetase
I6I67_03075	COG2814	Major facilitator Superfamily
I6I67_03080	COG2838	Isocitrate dehydrogenase
I6I67_03115	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6I67_03125	COG1595	DNA-templated transcription, initiation
I6I67_03145	COG2873	o-acetylhomoserine
I6I67_03150	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I6I67_03160	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
I6I67_03165	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
I6I67_03170	COG0469	pyruvate kinase activity
I6I67_03210	COG0587	DNA-directed DNA polymerase activity
I6I67_03220	COG1464	Belongs to the NlpA lipoprotein family
I6I67_03230	COG2011	ABC-type metal ion transport system permease component
I6I67_03300	COG0516	GMP reductase activity
I6I67_03340	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
I6I67_03350	COG1136	(ABC) transporter
I6I67_03350	COG0577	efflux transmembrane transporter activity
I6I67_03370	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
I6I67_03375	COG0456	acetyltransferase
I6I67_03390	COG2985	domain, Protein
I6I67_03390	COG0569	domain protein
I6I67_03400	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
I6I67_03405	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
I6I67_03425	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I6I67_03430	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
I6I67_03455	COG1674	ftsk spoiiie
I6I67_03465	COG1404	Belongs to the peptidase S8 family
I6I67_03475	COG0101	tRNA pseudouridine synthase activity
I6I67_03480	COG0203	ribosomal protein L17
I6I67_03485	COG0202	RNA polymerase activity
I6I67_03490	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
I6I67_03495	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
I6I67_03500	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
I6I67_03520	COG0563	adenylate kinase activity
I6I67_03525	COG0201	protein transport
I6I67_03530	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
I6I67_03540	COG0200	Binds to the 23S rRNA
I6I67_03545	COG1841	ribosomal large subunit assembly
I6I67_03550	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
I6I67_03555	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
I6I67_03560	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
I6I67_03575	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
I6I67_03585	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
I6I67_03590	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
I6I67_03595	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
I6I67_03615	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
I6I67_03645	COG1215	transferase activity, transferring glycosyl groups
I6I67_03655	COG1215	transferase activity, transferring glycosyl groups
I6I67_03660	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
I6I67_03665	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
I6I67_03675	COG0218	Necessary for normal cell division and for the maintenance of normal septation
I6I67_03685	COG1621	beta-fructofuranosidase activity
I6I67_03705	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
I6I67_03710	COG0255	Belongs to the universal ribosomal protein uL29 family
I6I67_03715	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
I6I67_03720	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
I6I67_03725	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
I6I67_03730	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
I6I67_03735	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
I6I67_03740	COG0089	rRNA binding
I6I67_03745	COG0088	Forms part of the polypeptide exit tunnel
I6I67_03750	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
I6I67_03755	COG0051	transcription antitermination factor activity, RNA binding
I6I67_03760	COG1302	Protein conserved in bacteria
I6I67_03805	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
I6I67_03810	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
I6I67_03815	COG0049	tRNA binding
I6I67_03820	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
I6I67_03835	COG1122	ATPase activity
I6I67_03840	COG4721	ABC-type cobalt transport system, permease component
I6I67_03855	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
I6I67_03875	COG0222	ribosome binding
I6I67_03880	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
I6I67_03885	COG1120	ATPase activity
I6I67_03890	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6I67_03895	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6I67_03920	COG0019	diaminopimelate decarboxylase activity
I6I67_03925	COG0081	regulation of translation
I6I67_03930	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
I6I67_03940	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
I6I67_03960	COG0435	Glutathione S-transferase
I6I67_03970	COG0142	geranyltranstransferase activity
I6I67_03980	COG2226	methyltransferase
I6I67_03985	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
I6I67_03985	COG0438	transferase activity, transferring glycosyl groups
I6I67_04010	COG4948	Mandelate Racemase Muconate Lactonizing
I6I67_04015	COG3069	C4-dicarboxylate transmembrane transporter activity
I6I67_04030	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
I6I67_04045	COG1321	iron dependent repressor
I6I67_04050	COG0803	Belongs to the bacterial solute-binding protein 9 family
I6I67_04055	COG1121	(ABC) transporter
I6I67_04060	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I6I67_04060	COG1321	iron dependent repressor
I6I67_04065	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I6I67_04070	COG1575	Belongs to the MenA family. Type 1 subfamily
I6I67_04090	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I6I67_04095	COG1333	cytochrome c biogenesis protein
I6I67_04100	COG0785	Cytochrome C biogenesis protein
I6I67_04110	COG0406	alpha-ribazole phosphatase activity
I6I67_04115	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
I6I67_04130	COG1136	(ABC) transporter
I6I67_04135	COG0577	efflux transmembrane transporter activity
I6I67_04135	COG1136	(ABC) transporter
I6I67_04150	COG5479	isomerase activity
I6I67_04150	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
I6I67_04155	COG2076	Multidrug Resistance protein
I6I67_04185	COG0488	(ABC) transporter
I6I67_04190	COG2161	toxin-antitoxin pair type II binding
I6I67_04195	COG4115	mRNA cleavage
I6I67_04200	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
I6I67_04205	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
I6I67_04220	COG0113	porphobilinogen synthase activity
I6I67_04225	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
I6I67_04225	COG1648	precorrin-2 dehydrogenase activity
I6I67_04230	COG0181	hydroxymethylbilane synthase activity
I6I67_04235	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
I6I67_04270	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
I6I67_04290	COG0745	RESPONSE REGULATOR receiver
I6I67_04295	COG5002	protein histidine kinase activity
I6I67_04305	COG0438	transferase activity, transferring glycosyl groups
I6I67_04310	COG0318	PFAM AMP-dependent synthetase and ligase
I6I67_04315	COG0318	PFAM AMP-dependent synthetase and ligase
I6I67_04325	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I6I67_04335	COG1690	Belongs to the RtcB family
I6I67_04350	COG1854	S-ribosylhomocysteine lyase activity
I6I67_04355	COG0812	UDP-N-acetylmuramate dehydrogenase activity
I6I67_04375	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
I6I67_04390	COG2733	membrane
I6I67_04405	COG1002	Type II restriction enzyme, methylase subunits
I6I67_04410	COG1061	Type III restriction enzyme res subunit
I6I67_04415	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
I6I67_04425	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
I6I67_04430	COG1053	succinate dehydrogenase
I6I67_04440	COG3800	Transcriptional regulator
I6I67_04440	COG1396	sequence-specific DNA binding
I6I67_04445	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6I67_04465	COG1088	dTDP-glucose 4,6-dehydratase activity
I6I67_04485	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
I6I67_04485	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I6I67_04495	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6I67_04510	COG0318	PFAM AMP-dependent synthetase and ligase
I6I67_04515	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6I67_04515	COG2190	(PTS) system
I6I67_04515	COG1263	PTS System
I6I67_04520	COG0363	glucosamine-6-phosphate deaminase activity
I6I67_04525	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
I6I67_04565	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I6I67_04565	COG1754	DNA topoisomerase type I activity
I6I67_04575	COG1278	Cold shock
I6I67_04580	COG1205	dead DEAH box helicase
I6I67_04580	COG1111	helicase
I6I67_04635	COG0596	Alpha beta hydrolase
I6I67_04640	COG4166	transmembrane transport
I6I67_04645	COG0601	transmembrane transport
I6I67_04650	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6I67_04675	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6I67_04685	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I6I67_04690	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6I67_04720	COG1408	metallophosphoesterase
I6I67_04765	COG3949	Membrane
I6I67_04775	COG3764	Sortase (surface protein transpeptidase)
I6I67_04795	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
I6I67_04800	COG0527	aspartate kinase activity
I6I67_04805	COG0697	spore germination
I6I67_04830	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
I6I67_04860	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6I67_04905	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I6I67_04920	COG1100	Small GTP-binding protein
I6I67_04970	COG0343	queuine tRNA-ribosyltransferase activity
I6I67_04975	COG2409	Drug exporters of the RND superfamily
I6I67_05005	COG0287	Prephenate dehydrogenase
I6I67_05035	COG0523	cobalamin synthesis protein
I6I67_05040	COG0471	metal ion transport
I6I67_05050	COG2149	membrane
I6I67_05055	COG0569	domain protein
I6I67_05060	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
I6I67_05065	COG1511	domain protein
I6I67_05110	COG3835	regulator
I6I67_05115	COG1113	amino acid transport
I6I67_05120	COG3961	Belongs to the TPP enzyme family
I6I67_05130	COG1950	PFAM Membrane protein of
I6I67_05145	COG0315	cyclic pyranopterin monophosphate synthase activity
I6I67_05145	COG0521	Mo-molybdopterin cofactor biosynthetic process
I6I67_05170	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
I6I67_05180	COG2026	Addiction module toxin, RelE StbE family
I6I67_05205	COG4221	oxidoreductase activity
I6I67_05205	COG3321	synthase
I6I67_05205	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I6I67_05205	COG0604	alcohol dehydrogenase
I6I67_05240	COG1216	Glycosyl transferase, family 2
I6I67_05270	COG0277	FAD linked oxidase domain protein
I6I67_05295	COG3590	peptidase
I6I67_05330	COG2501	S4 domain
I6I67_05335	COG1280	lysine exporter protein (LysE YggA)
I6I67_05345	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I6I67_05350	COG1012	belongs to the aldehyde dehydrogenase family
I6I67_05365	COG0110	maltose O-acetyltransferase activity
I6I67_05370	COG1643	Atp-dependent helicase
I6I67_05375	COG0730	response to heat
I6I67_05380	COG3180	Ammonia monooxygenase
I6I67_05410	COG1528	Iron-storage protein
I6I67_05415	COG0659	secondary active sulfate transmembrane transporter activity
I6I67_05420	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
I6I67_05425	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
I6I67_05435	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
I6I67_05445	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
I6I67_05450	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I6I67_05550	COG2801	Transposase and inactivated derivatives
I6I67_05600	COG1716	ATPase activity
I6I67_05600	COG1716	ATPase activity
I6I67_05605	COG1716	ATPase activity
I6I67_05620	COG0768	penicillin binding
I6I67_05625	COG0515	serine threonine protein kinase
I6I67_05630	COG2815	serine threonine protein kinase
I6I67_05630	COG0515	serine threonine protein kinase
I6I67_05675	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
I6I67_05695	COG1132	(ABC) transporter
I6I67_05715	COG0726	polysaccharide deacetylase
I6I67_05750	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
I6I67_05775	COG0187	DNA topoisomerase II activity
I6I67_05785	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
I6I67_05790	COG0592	DNA-directed DNA polymerase activity
I6I67_05795	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
I6I67_05800	COG0230	Belongs to the bacterial ribosomal protein bL34 family
I6I67_05805	COG0594	ribonuclease P activity
I6I67_05810	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
I6I67_05825	COG1192	Involved in chromosome partitioning
I6I67_05840	COG3409	Peptidoglycan-binding domain 1 protein
I6I67_05840	COG0860	N-Acetylmuramoyl-L-alanine amidase
I6I67_05845	COG3118	belongs to the thioredoxin family
I6I67_05865	COG2353	YceI-like domain
I6I67_05885	COG0617	tRNA 3'-terminal CCA addition
I6I67_05890	COG1678	Uncharacterized ACR, COG1678
I6I67_05895	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
I6I67_05940	COG1484	DNA-dependent DNA replication
I6I67_05945	COG4584	PFAM Integrase catalytic
I6I67_05945	COG2390	Transcriptional regulator
I6I67_05955	COG0159	tryptophan synthase activity
I6I67_05965	COG0134	indole-3-glycerol-phosphate synthase activity
I6I67_05965	COG0135	phosphoribosylanthranilate isomerase activity
I6I67_05970	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I6I67_05975	COG0512	Glutamine amidotransferase of anthranilate synthase
I6I67_05980	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
I6I67_05995	COG1116	anion transmembrane transporter activity
I6I67_05995	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6I67_06005	COG0477	Major facilitator Superfamily
I6I67_06015	COG1802	Transcriptional regulator
I6I67_06020	COG1012	belongs to the aldehyde dehydrogenase family
I6I67_06030	COG3971	2-oxopent-4-enoate hydratase activity
I6I67_06060	COG1012	belongs to the aldehyde dehydrogenase family
I6I67_06100	COG3177	Filamentation induced by cAMP protein fic
I6I67_06155	COG1715	Restriction endonuclease
I6I67_06160	COG3311	Transcriptional regulator
I6I67_06165	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
I6I67_06170	COG0495	leucyl-tRNA aminoacylation
I6I67_06195	COG3573	Dehydrogenase
I6I67_06200	COG0733	neurotransmitter:sodium symporter activity
I6I67_06210	COG0604	alcohol dehydrogenase
I6I67_06225	COG2197	response regulator
I6I67_06230	COG4585	Histidine kinase
I6I67_06235	COG0577	efflux transmembrane transporter activity
I6I67_06240	COG1136	(ABC) transporter
I6I67_06260	COG4868	Belongs to the UPF0371 family
I6I67_06265	COG1054	Belongs to the UPF0176 family
I6I67_06280	COG1846	Transcriptional regulator
I6I67_06290	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I6I67_06305	COG0360	Binds together with S18 to 16S ribosomal RNA
I6I67_06315	COG0359	binds to the 23S rRNA
I6I67_06320	COG0305	Participates in initiation and elongation during chromosome replication
I6I67_06330	COG0477	Major facilitator Superfamily
I6I67_06345	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6I67_06350	COG1842	Phage shock protein A
I6I67_06365	COG1131	(ABC) transporter
I6I67_06395	COG0564	pseudouridine synthase activity
I6I67_06420	COG0706	membrane insertase activity
I6I67_06425	COG3764	Sortase (surface protein transpeptidase)
I6I67_06440	COG2203	Gaf domain
I6I67_06440	COG4585	Histidine kinase
I6I67_06445	COG2197	response regulator
I6I67_06470	COG2814	Major facilitator Superfamily
I6I67_06475	COG0583	DNA-binding transcription factor activity
I6I67_06490	COG1966	Carbon starvation protein
I6I67_06500	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I6I67_06515	COG0584	glycerophosphoryl diester phosphodiesterase
I6I67_06525	COG1316	TRANSCRIPTIONal
I6I67_06540	COG0077	Prephenate dehydratase
I6I67_06560	COG2188	Transcriptional regulator
I6I67_06565	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
I6I67_06575	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
I6I67_06580	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
I6I67_06585	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
I6I67_06590	COG0561	phosphatase activity
I6I67_06635	COG1216	Glycosyl transferase, family 2
I6I67_06645	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
I6I67_06650	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
I6I67_06655	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
I6I67_06660	COG5479	isomerase activity
I6I67_06660	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
I6I67_06670	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
I6I67_06675	COG0318	PFAM AMP-dependent synthetase and ligase
I6I67_06680	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I6I67_06680	COG3321	synthase
I6I67_06680	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
I6I67_06685	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I6I67_06720	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
I6I67_06730	COG0297	glycogen (starch) synthase activity
I6I67_06750	COG4981	capsule polysaccharide biosynthetic process
I6I67_06765	COG1472	Belongs to the glycosyl hydrolase 3 family
I6I67_06775	COG1132	(ABC) transporter
I6I67_06800	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
I6I67_06830	COG0247	lactate metabolic process
I6I67_06830	COG2181	nitrate reductase activity
I6I67_06850	COG0175	sulfate reduction
I6I67_06885	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
I6I67_06895	COG1012	belongs to the aldehyde dehydrogenase family
I6I67_06900	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I6I67_06905	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6I67_06910	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6I67_06915	COG1120	ATPase activity
I6I67_06920	COG0443	Heat shock 70 kDa protein
I6I67_06935	COG0789	Transcriptional regulator
I6I67_06950	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I6I67_06985	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
I6I67_07000	COG0191	fructose-bisphosphate aldolase activity
I6I67_07015	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
I6I67_07020	COG0471	metal ion transport
I6I67_07025	COG4129	membrane
I6I67_07050	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
I6I67_07075	COG3711	transcriptional antiterminator
I6I67_07085	COG0280	phosphate acetyltransferase
I6I67_07090	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
I6I67_07100	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6I67_07115	COG1131	(ABC) transporter
I6I67_07125	COG2814	Major facilitator Superfamily
I6I67_07145	COG0242	peptide deformylase activity
I6I67_07165	COG1051	belongs to the nudix hydrolase family
I6I67_07185	COG0651	ATP synthesis coupled electron transport
I6I67_07190	COG1006	Multisubunit Na H antiporter MnhC subunit
I6I67_07195	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I6I67_07195	COG2111	Na H antiporter
I6I67_07205	COG1297	OPT oligopeptide transporter protein
I6I67_07220	COG2326	polyphosphate kinase activity
I6I67_07240	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I6I67_07260	COG1136	(ABC) transporter
I6I67_07280	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
I6I67_07285	COG2027	D-alanyl-D-alanine carboxypeptidase
I6I67_07300	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I6I67_07305	COG0302	gtp cyclohydrolase
I6I67_07320	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
I6I67_07340	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
I6I67_07355	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
I6I67_07365	COG0477	Major facilitator Superfamily
I6I67_07375	COG0542	response to heat
I6I67_07415	COG1194	a g-specific adenine glycosylase
I6I67_07430	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
I6I67_07435	COG2847	Copper chaperone PCu(A)C
I6I67_07460	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6I67_07465	COG1129	ABC transporter
I6I67_07485	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I6I67_07490	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
I6I67_07490	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
I6I67_07500	COG1609	Transcriptional regulator
I6I67_07505	COG1877	trehalose-phosphatase activity
I6I67_07515	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
I6I67_07545	COG0477	Major facilitator Superfamily
I6I67_07550	COG0028	Belongs to the TPP enzyme family
I6I67_07560	COG0789	Transcriptional regulator
I6I67_07560	COG4978	Transcriptional regulator
I6I67_07565	COG0745	RESPONSE REGULATOR receiver
I6I67_07570	COG2205	protein histidine kinase activity
I6I67_07585	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
I6I67_07620	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
I6I67_07625	COG0047	phosphoribosylformylglycinamidine synthase activity
I6I67_07630	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
I6I67_07645	COG0446	pyridine nucleotide-disulphide oxidoreductase
I6I67_07660	COG1272	protein, Hemolysin III
I6I67_07675	COG0183	Belongs to the thiolase family
I6I67_07680	COG1028	Short-chain dehydrogenase reductase Sdr
I6I67_07685	COG2030	dehydratase
I6I67_07705	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
I6I67_07730	COG1597	lipid kinase activity
I6I67_07740	COG0456	acetyltransferase
I6I67_07760	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
I6I67_07785	COG1937	Protein conserved in bacteria
I6I67_07815	COG1045	serine acetyltransferase
I6I67_07820	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I6I67_07825	COG2197	response regulator
I6I67_07830	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
I6I67_07865	COG2801	Transposase and inactivated derivatives
I6I67_07880	COG2390	Transcriptional regulator
I6I67_07880	COG4584	PFAM Integrase catalytic
I6I67_07890	COG2239	Acts as a magnesium transporter
I6I67_07910	COG1136	(ABC) transporter
I6I67_07910	COG0577	efflux transmembrane transporter activity
I6I67_07915	COG0577	efflux transmembrane transporter activity
I6I67_07915	COG1136	(ABC) transporter
I6I67_07920	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
I6I67_07925	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
I6I67_07930	COG0033	Phosphoglucomutase
I6I67_07970	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
I6I67_07975	COG2814	Major facilitator Superfamily
I6I67_07980	COG0257	Belongs to the bacterial ribosomal protein bL36 family
I6I67_07995	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6I67_08000	COG2186	Transcriptional regulator
I6I67_08005	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6I67_08010	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
I6I67_08030	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
I6I67_08040	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
I6I67_08065	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
I6I67_08090	COG1349	DNA-binding transcription factor activity
I6I67_08110	COG1882	Formate acetyltransferase
I6I67_08120	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
I6I67_08135	COG0747	negative chemotaxis
I6I67_08205	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I6I67_08210	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6I67_08215	COG1120	ATPase activity
I6I67_08240	COG1376	ErfK ybiS ycfS ynhG family protein
I6I67_08245	COG0045	succinate-CoA ligase (ADP-forming) activity
I6I67_08255	COG2094	Belongs to the DNA glycosylase MPG family
I6I67_08270	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
I6I67_08275	COG1115	amino acid carrier protein
I6I67_08280	COG4221	oxidoreductase activity
I6I67_08300	COG0583	DNA-binding transcription factor activity
I6I67_08305	COG1276	copper resistance
I6I67_08330	COG0686	Belongs to the AlaDH PNT family
I6I67_08340	COG0668	transmembrane transport
I6I67_08355	COG0747	negative chemotaxis
I6I67_08360	COG0601	transmembrane transport
I6I67_08365	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6I67_08380	COG0300	oxidoreductase activity
I6I67_08385	COG2188	Transcriptional regulator
I6I67_08410	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
I6I67_08595	COG0756	dUTP diphosphatase activity
I6I67_08625	COG1121	(ABC) transporter
I6I67_08630	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
I6I67_08735	COG0739	heme binding
I6I67_08785	COG3723	Recombinational DNA repair protein, rece pathway
I6I67_08825	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
I6I67_08910	COG2189	Belongs to the N(4) N(6)-methyltransferase family
I6I67_08925	COG0756	dUTP diphosphatase activity
I6I67_08930	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6I67_09075	COG0739	heme binding
I6I67_09145	COG0544	peptidyl-prolyl cis-trans isomerase activity
I6I67_09150	COG0431	NADPH-dependent FMN reductase
I6I67_09160	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6I67_09165	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6I67_09170	COG1780	Probably involved in ribonucleotide reductase function
I6I67_09185	COG0740	serine-type endopeptidase activity
I6I67_09190	COG1028	Short-chain dehydrogenase reductase Sdr
I6I67_09195	COG2814	Major facilitator Superfamily
I6I67_09200	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
I6I67_09205	COG2390	Transcriptional regulator
I6I67_09210	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I6I67_09215	COG0295	cytidine deaminase activity
I6I67_09225	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
I6I67_09230	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I6I67_09240	COG0039	L-malate dehydrogenase activity
I6I67_09250	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
I6I67_09260	COG0285	dihydrofolate synthase activity
I6I67_09280	COG0105	UTP biosynthetic process
I6I67_09285	COG0640	Transcriptional regulator
I6I67_09290	COG0798	PFAM Bile acid sodium symporter
I6I67_09300	COG1530	ribonuclease E activity
I6I67_09305	COG0261	This protein binds to 23S rRNA in the presence of protein L20
I6I67_09310	COG0211	Belongs to the bacterial ribosomal protein bL27 family
I6I67_09330	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I6I67_09360	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
I6I67_09370	COG0406	alpha-ribazole phosphatase activity
I6I67_09375	COG1307	EDD domain protein, DegV family
I6I67_09415	COG0268	Binds directly to 16S ribosomal RNA
I6I67_09425	COG0481	GTPase activity
I6I67_09445	COG1473	amidohydrolase
I6I67_09465	COG4585	Histidine kinase
I6I67_09470	COG2197	response regulator
I6I67_09480	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I6I67_09490	COG4172	Belongs to the ABC transporter superfamily
I6I67_09505	COG0747	negative chemotaxis
I6I67_09510	COG2186	Transcriptional regulator
I6I67_09515	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6I67_09520	COG1114	Component of the transport system for branched-chain amino acids
I6I67_09530	COG1132	(ABC) transporter
I6I67_09540	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
I6I67_09560	COG1022	Amp-dependent synthetase and ligase
I6I67_09570	COG1253	flavin adenine dinucleotide binding
I6I67_09575	COG1253	flavin adenine dinucleotide binding
I6I67_09590	COG1420	regulation of RNA biosynthetic process
I6I67_09610	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
I6I67_09625	COG1381	Involved in DNA repair and RecF pathway recombination
I6I67_09630	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
I6I67_09645	COG0423	glycine-tRNA ligase activity
I6I67_09705	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
I6I67_09725	COG0297	glycogen (starch) synthase activity
I6I67_09730	COG0438	transferase activity, transferring glycosyl groups
I6I67_09745	COG0463	Glycosyl transferase, family 2
I6I67_09755	COG1134	teichoic acid transport
I6I67_09765	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
I6I67_09865	COG4988	ABC transporter
I6I67_09885	COG3311	Transcriptional regulator
I6I67_09905	COG2860	membrane
I6I67_09915	COG0668	transmembrane transport
I6I67_09940	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I6I67_09945	COG2267	carboxylic ester hydrolase activity
I6I67_09950	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
I6I67_09975	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
I6I67_10020	COG0174	glutamine synthetase
I6I67_10025	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
I6I67_10040	COG2271	Major facilitator Superfamily
I6I67_10045	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
I6I67_10090	COG1120	ATPase activity
I6I67_10105	COG0174	glutamine synthetase
I6I67_10120	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
I6I67_10125	COG0321	lipoyl(octanoyl) transferase activity
I6I67_10130	COG0509	glycine decarboxylation via glycine cleavage system
I6I67_10135	COG0404	The glycine cleavage system catalyzes the degradation of glycine
I6I67_10140	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
I6I67_10140	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
I6I67_10150	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6I67_10160	COG1335	isochorismatase
I6I67_10165	COG2066	Belongs to the glutaminase family
I6I67_10175	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I6I67_10180	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
I6I67_10240	COG0438	transferase activity, transferring glycosyl groups
I6I67_10245	COG1940	carbohydrate kinase activity
I6I67_10265	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
I6I67_10285	COG0142	geranyltranstransferase activity
I6I67_10310	COG1136	(ABC) transporter
I6I67_10325	COG0275	rRNA processing
I6I67_10335	COG0768	penicillin binding
I6I67_10340	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
I6I67_10350	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I6I67_10365	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
I6I67_10370	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
I6I67_10375	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
I6I67_10380	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
I6I67_10385	COG1496	oxidoreductase activity
I6I67_10390	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
I6I67_10395	COG1799	cell septum assembly
I6I67_10405	COG3599	regulation of cell shape
I6I67_10420	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
I6I67_10440	COG0252	asparaginase activity
I6I67_10485	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
I6I67_10510	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I6I67_10515	COG1739	Uncharacterized protein family UPF0029
I6I67_10540	COG2176	DNA-directed DNA polymerase activity
I6I67_10570	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
I6I67_10575	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
I6I67_10580	COG0131	Imidazoleglycerol-phosphate dehydratase
I6I67_10595	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
I6I67_10605	COG0483	inositol monophosphate 1-phosphatase activity
I6I67_10610	COG0107	imidazoleglycerol-phosphate synthase activity
I6I67_10630	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
I6I67_10635	COG0469	pyruvate kinase activity
I6I67_10640	COG0058	SHG alpha-glucan phosphorylase activity
I6I67_10655	COG1929	Belongs to the glycerate kinase type-1 family
I6I67_10660	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I6I67_10680	COG0571	ribonuclease III activity
I6I67_10685	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
I6I67_10690	COG1115	amino acid carrier protein
I6I67_10695	COG1254	Belongs to the acylphosphatase family
I6I67_10710	COG2111	Na H antiporter
I6I67_10710	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I6I67_10715	COG1006	Multisubunit Na H antiporter MnhC subunit
I6I67_10720	COG0651	ATP synthesis coupled electron transport
I6I67_10750	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
I6I67_10760	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
I6I67_10760	COG2755	lipolytic protein G-D-S-L family
I6I67_10765	COG0228	four-way junction DNA binding
I6I67_10785	COG0336	Belongs to the RNA methyltransferase TrmD family
I6I67_10815	COG2022	thiamine diphosphate biosynthetic process
I6I67_10830	COG0352	thiamine-phosphate diphosphorylase activity
I6I67_10845	COG0681	Belongs to the peptidase S26 family
I6I67_10850	COG0681	Belongs to the peptidase S26 family
I6I67_10855	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
I6I67_10865	COG0792	nuclease activity
I6I67_10880	COG4974	Belongs to the 'phage' integrase family
I6I67_10895	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
I6I67_10900	COG0528	UMP kinase activity
I6I67_10905	COG0233	cytoplasmic translational termination
I6I67_10910	COG0575	Belongs to the CDS family
I6I67_10920	COG0820	rRNA (adenine-C2-)-methyltransferase activity
I6I67_10925	COG1131	(ABC) transporter
I6I67_10940	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
I6I67_10950	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
I6I67_10955	COG0768	penicillin binding
I6I67_10995	COG0579	oxidoreductase
I6I67_11000	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
I6I67_11015	COG3022	response to hydroperoxide
I6I67_11020	COG0442	prolyl-tRNA aminoacylation
I6I67_11035	COG0779	Required for maturation of 30S ribosomal subunits
I6I67_11050	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
I6I67_11055	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
I6I67_11060	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
I6I67_11065	COG0534	Mate efflux family protein
I6I67_11070	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
I6I67_11075	COG2977	Belongs to the P-Pant transferase superfamily
I6I67_11080	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
I6I67_11095	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
I6I67_11100	COG1185	polyribonucleotide nucleotidyltransferase activity
I6I67_11120	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
I6I67_11125	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
I6I67_11130	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6I67_11135	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
I6I67_11145	COG1674	ftsk spoiiie
I6I67_11160	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
I6I67_11170	COG1396	sequence-specific DNA binding
I6I67_11175	COG1842	Phage shock protein A
I6I67_11180	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
I6I67_11185	COG1122	ATPase activity
I6I67_11190	COG1268	BioY protein
I6I67_11205	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
I6I67_11210	COG2137	regulation of response to DNA damage stimulus
I6I67_11215	COG0765	amino acid transport
I6I67_11220	COG0765	amino acid transport
I6I67_11225	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6I67_11230	COG1126	abc transporter atp-binding protein
I6I67_11245	COG1902	pentaerythritol trinitrate reductase activity
I6I67_11255	COG1196	nuclear chromosome segregation
I6I67_11270	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
I6I67_11285	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
I6I67_11290	COG2233	PERMEase
I6I67_11295	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6I67_11300	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6I67_11300	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6I67_11300	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
I6I67_11305	COG1105	Belongs to the carbohydrate kinase PfkB family
I6I67_11310	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I6I67_11315	COG1349	DNA-binding transcription factor activity
I6I67_11325	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
I6I67_11330	COG1643	Atp-dependent helicase
I6I67_11345	COG0450	alkyl hydroperoxide reductase
I6I67_11350	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I6I67_11385	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I6I67_11390	COG1321	iron dependent repressor
I6I67_11420	COG1061	Type III restriction enzyme res subunit
I6I67_11425	COG2376	Dihydroxyacetone kinase
I6I67_11430	COG1461	Dihydroxyacetone kinase
I6I67_11475	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
I6I67_11480	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
I6I67_11485	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
I6I67_11495	COG3253	May function as heme-dependent peroxidase
I6I67_11500	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I6I67_11570	COG2837	iron assimilation
I6I67_11575	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
I6I67_11585	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
I6I67_11590	COG1560	Kdo2-lipid A biosynthetic process
I6I67_11595	COG0438	transferase activity, transferring glycosyl groups
I6I67_11620	COG1946	Acyl-CoA thioesterase
I6I67_11625	COG0217	transcriptional regulatory protein
I6I67_11635	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
I6I67_11640	COG0632	four-way junction helicase activity
I6I67_11645	COG2255	four-way junction helicase activity
I6I67_11655	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I6I67_11660	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I6I67_11675	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I6I67_11680	COG0737	Belongs to the 5'-nucleotidase family
I6I67_11685	COG2323	membrane
I6I67_11705	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
I6I67_11710	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6I67_11715	COG0124	histidyl-tRNA synthetase
I6I67_11720	COG1760	l-serine dehydratase
I6I67_11750	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
I6I67_11770	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
I6I67_11780	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
I6I67_11790	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
I6I67_11795	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
I6I67_11805	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
I6I67_11810	COG0006	proline dipeptidase activity
I6I67_11815	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
I6I67_11820	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
I6I67_11825	COG1126	abc transporter atp-binding protein
I6I67_11830	COG0765	amino acid transport
I6I67_11835	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6I67_11870	COG0539	negative regulation of cytoplasmic translation
I6I67_11875	COG0237	dephospho-CoA kinase activity
I6I67_11910	COG3973	AAA domain
I6I67_11940	COG0291	Belongs to the bacterial ribosomal protein bL35 family
I6I67_11945	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
I6I67_11960	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6I67_11970	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6I67_11970	COG0072	phenylalanine-tRNA ligase activity
I6I67_11980	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
I6I67_11985	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
I6I67_11995	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I6I67_12000	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
I6I67_12005	COG1438	arginine binding
I6I67_12010	COG0137	argininosuccinate synthase activity
I6I67_12015	COG0165	Argininosuccinate lyase
I6I67_12035	COG2304	oxidoreductase activity
I6I67_12045	COG2835	tetraacyldisaccharide 4'-kinase activity
I6I67_12085	COG0647	UMP catabolic process
I6I67_12100	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
I6I67_12120	COG0494	nUDIX hydrolase
I6I67_12125	COG4974	Belongs to the 'phage' integrase family
I6I67_12145	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
I6I67_12155	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
I6I67_12160	COG1160	GTP binding
I6I67_12165	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
I6I67_12170	COG2197	response regulator
I6I67_12175	COG4585	Histidine kinase
I6I67_12185	COG1131	(ABC) transporter
I6I67_12225	COG3012	SEC-C Motif Domain Protein
I6I67_12235	COG0653	protein targeting
I6I67_12240	COG1716	ATPase activity
I6I67_12270	COG0513	Belongs to the DEAD box helicase family
I6I67_12285	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
I6I67_12295	COG0598	Magnesium transport protein CorA
I6I67_12305	COG0352	thiamine-phosphate diphosphorylase activity
I6I67_12305	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
I6I67_12305	COG0351	phosphomethylpyrimidine kinase
I6I67_12330	COG0477	Major facilitator Superfamily
I6I67_12375	COG3842	ATPase activity
I6I67_12380	COG0463	Glycosyl transferase, family 2
I6I67_12400	COG0300	oxidoreductase activity
I6I67_12420	COG0805	protein transport
I6I67_12425	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I6I67_12440	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
I6I67_12450	COG4122	O-methyltransferase activity
I6I67_12455	COG1222	aaa ATPase
I6I67_12465	COG1362	aminopeptidase activity
I6I67_12480	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
I6I67_12485	COG1027	Aspartate ammonia-lyase
I6I67_12490	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
I6I67_12495	COG0140	phosphoribosyl-ATP diphosphatase activity
I6I67_12500	COG0546	phosphoglycolate phosphatase activity
I6I67_12510	COG0215	cysteine-tRNA ligase activity
I6I67_12515	COG1968	undecaprenyl-diphosphatase activity
I6I67_12525	COG0167	dihydroorotate dehydrogenase activity
I6I67_12535	COG1881	PFAM PEBP family protein
I6I67_12555	COG0398	Pfam SNARE associated Golgi protein
I6I67_12575	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
I6I67_12580	COG0791	NLP P60 protein
I6I67_12580	COG3883	PFAM NLP P60 protein
I6I67_12590	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
I6I67_12620	COG3830	Belongs to the UPF0237 family
I6I67_12625	COG2848	UPF0210 protein
I6I67_12660	COG0488	(ABC) transporter
I6I67_12665	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6I67_12665	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6I67_12665	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6I67_12675	COG0822	iron-sulfur transferase activity
I6I67_12685	COG0396	ATPase activity
I6I67_12740	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
I6I67_12760	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
I6I67_12770	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
I6I67_12775	COG1481	regulation of sporulation
I6I67_12785	COG1660	Displays ATPase and GTPase activities
I6I67_12790	COG0322	excinuclease ABC activity
I6I67_12800	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
I6I67_12830	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
I6I67_12835	COG0242	peptide deformylase activity
I6I67_12845	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
I6I67_12855	COG1758	RNA polymerase activity
I6I67_12870	COG0284	orotidine-5'-phosphate decarboxylase activity
I6I67_12875	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
I6I67_12880	COG0505	Belongs to the CarA family
I6I67_12885	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
I6I67_12890	COG0540	Belongs to the ATCase OTCase family
I6I67_12900	COG1090	epimerase
I6I67_12925	COG2326	polyphosphate kinase activity
I6I67_12935	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
I6I67_12940	COG0742	ribosomal rna small subunit methyltransferase
I6I67_12945	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
I6I67_12950	COG1461	Dihydroxyacetone kinase
I6I67_12955	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
I6I67_12960	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
I6I67_12970	COG1181	Belongs to the D-alanine--D-alanine ligase family
I6I67_12975	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
I6I67_12980	COG0406	alpha-ribazole phosphatase activity
I6I67_12980	COG0494	nUDIX hydrolase
I6I67_12990	COG0066	3-isopropylmalate dehydratase activity
I6I67_12995	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
I6I67_13080	COG1121	(ABC) transporter
I6I67_13085	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I6I67_13100	COG0179	Fumarylacetoacetate (FAA) hydrolase
I6I67_13115	COG0473	3-isopropylmalate dehydrogenase activity
I6I67_13135	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
I6I67_13145	COG0028	Belongs to the TPP enzyme family
I6I67_13155	COG0129	dihydroxy-acid dehydratase activity
I6I67_13160	COG5650	phosphatidylinositol metabolic process
I6I67_13170	COG3547	Transposase (IS116 IS110 IS902 family)
I6I67_13180	COG0583	DNA-binding transcription factor activity
I6I67_13190	COG3949	Membrane
I6I67_13195	COG1064	alcohol dehydrogenase
I6I67_13205	COG2985	domain, Protein
I6I67_13205	COG0569	domain protein
I6I67_13210	COG0205	6-phosphofructokinase activity
I6I67_13235	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
I6I67_13255	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
I6I67_13270	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I6I67_13300	COG0482	sulfurtransferase activity