locus-tag class description CDCE8392_0002 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) CDCE8392_0005 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) CDCE8392_0009 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) CDCE8392_0012 ENOG4105DAA L-lactate CDCE8392_0014 ENOG4108JJ9 ABC, transporter CDCE8392_0015 ENOG4105BZ1 (ABC) transporter CDCE8392_0019 ENOG4108HWV )-transporter CDCE8392_0020 ENOG4105C2J ABC transporter CDCE8392_0023 ENOG4105DQ6 Transposase CDCE8392_0026 ENOG4107Y5I Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) CDCE8392_0027 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) CDCE8392_0030 ENOG4105DWF phosphomethylpyrimidine kinase CDCE8392_0038 ENOG4105TZK CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. May be involved in the integration of spacer DNA into the CRISPR cassette (By similarity) CDCE8392_0039 ENOG4105PWE CRISPR-associated protein cas2 CDCE8392_0040 ENOG4105XBB septation inhibitor protein CDCE8392_0041 ENOG4108DT4 serine threonine protein kinase CDCE8392_0043 ENOG4105CJN penicillin-binding protein CDCE8392_0047 ENOG4105TV9 FHA Domain-Containing protein CDCE8392_0047 ENOG4105TV9 FHA Domain-Containing protein CDCE8392_0051 ENOG4105JAB phenazine biosynthesis protein, phzf family CDCE8392_0054 ENOG4105WH1 Two component transcriptional regulator luxr family CDCE8392_0055 ENOG4105BZU Histidine kinase CDCE8392_0058 ENOG4105E90 ABC transporter CDCE8392_0059 ENOG4105R40 Glycine betaine carnitine choline CDCE8392_0060 ENOG4108IJ8 ABC transporter CDCE8392_0065 ENOG4107TXC Transcriptional regulator CDCE8392_0067 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) CDCE8392_0071 ENOG4105EHG Permease protein CDCE8392_0072 ENOG4105E0A ABC, transporter CDCE8392_0074 ENOG4108ZMX Domain of unknown function (DU1801) CDCE8392_0075 ENOG4105CVP deoxyribo-dipyrimidine photolyase CDCE8392_0081 ENOG4105CB5 ATP-dependent DNA helicase recG CDCE8392_0084 ENOG4108Z0R Transferase CDCE8392_0087 ENOG4108URH decarboxylase CDCE8392_0089 ENOG4105K56 Transcriptional regulator CDCE8392_0090 ENOG4108KK1 membrane protein AbrB duplication CDCE8392_0093 ENOG4105CQ7 ATP-dependent helicase CDCE8392_0095 ENOG4105CF1 Alkylated DNA repair protein CDCE8392_0103 ENOG4105F9F transposase CDCE8392_0104 ENOG4105F9F transposase CDCE8392_0107 ENOG410848D S4 domain protein YaaA CDCE8392_0111 ENOG4105C9K Endothelin-converting enzyme 1 CDCE8392_0116 ENOG4105J1Z Arabinosyltransferase CDCE8392_0117 ENOG4108K7T Involved in the biosynthesis of the arabinogalactan (AG) region of the mycolylarabinogalactan-peptidoglycan (mAGP) complex, an essential component the mycobacterial cell wall. Catalyzes the addition of the first key arabinofuranosyl (Araf) residue from the sugar donor beta-D-arabinofuranosyl-1-monophosphoryldecaprenol (DPA) on the C-5 of a 6-linked galactofuranosyl (Galf) of the galactan domain, thus 'priming' the galactan for further elaboration by other arabinofuranosyltransferases CDCE8392_0118 ENOG4108RG3 short-chain dehydrogenase reductase CDCE8392_0119 ENOG4105IQ5 FAD linked oxidase domain protein CDCE8392_0125 ENOG4108MKI Glycosyl transferase, family 2 CDCE8392_0126 ENOG4105DSE periplasmic solute binding protein CDCE8392_0127 ENOG4105DIK (ABC) transporter CDCE8392_0128 ENOG4107RPQ ABC transporter CDCE8392_0129 ENOG4107RBD ABC, transporter CDCE8392_0130 ENOG4105DSE periplasmic solute binding protein CDCE8392_0134 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein CDCE8392_0136 ENOG4105C8P )-transporter CDCE8392_0137 ENOG4105C8P )-transporter CDCE8392_0139 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) CDCE8392_0180 ENOG4108ZJ4 polysaccharide deacetylase CDCE8392_0181 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family CDCE8392_0185 ENOG410836F Transposase CDCE8392_0187 ENOG410836F Transposase CDCE8392_0200 ENOG4105EVN Prephenate dehydrogenase CDCE8392_0202 ENOG4108Z6B deaminase CDCE8392_0205 ENOG4105EYF MMPL domain protein CDCE8392_0207 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) CDCE8392_0209 ENOG4105C6Z Gluconate CDCE8392_0210 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family CDCE8392_0212 ENOG4105CHR reductase CDCE8392_0213 ENOG4105XT2 Transcriptional regulator CDCE8392_0218 ENOG4105CAA catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation (By similarity) CDCE8392_0219 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) CDCE8392_0221 ENOG4108DBC nitroreductase CDCE8392_0223 ENOG4107RHR regulatoR CDCE8392_0227 ENOG4108J8C transporter major facilitator family protein CDCE8392_0229 ENOG4107QSU Phosphoglucomutase phosphomannomutase alpha beta alpha domain CDCE8392_0231 ENOG4105PP6 Membrane CDCE8392_0232 ENOG4105CFH Aspartokinase CDCE8392_0235 ENOG4105CH6 catalase CDCE8392_0239 ENOG4105CXY transporter CDCE8392_0240 ENOG4105CK6 Two component transcriptional regulator (Winged helix family CDCE8392_0241 ENOG4105BZU Histidine kinase CDCE8392_0245 ENOG4108JPZ Monovalent cation H antiporter subunit D CDCE8392_0246 ENOG4105MKQ Monovalent cation H antiporter subunit C CDCE8392_0247 ENOG4105D65 subunit l CDCE8392_0253 ENOG4105BZ4 penicillin-binding protein CDCE8392_0254 ENOG4105N0U Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) CDCE8392_0257 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) CDCE8392_0258 ENOG4105IJJ transcriptional regulator, crp fnr family CDCE8392_0275 ENOG4108I5C dEAD DEAH box helicase CDCE8392_0276 ENOG4105VEQ Cold shock protein CDCE8392_0278 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) CDCE8392_0282 ENOG4105CGD Nad-dependent epimerase dehydratase CDCE8392_0283 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) CDCE8392_0285 ENOG4105EPD Oligopeptide transporter, Opt family CDCE8392_0289 ENOG4107QRG dna polymerase iii CDCE8392_0296 ENOG4105DQ6 Transposase CDCE8392_0299 ENOG4105F9F transposase CDCE8392_0301 ENOG4107R3N Filamentation induced by cAMP protein fic CDCE8392_0302 ENOG4105CF1 Alkylated DNA repair protein CDCE8392_0309 ENOG4105CEY Amp-dependent synthetase and ligase CDCE8392_0311 ENOG4107QPT Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) CDCE8392_0313 ENOG4105C1B dTDP-glucose 4-6-dehydratase CDCE8392_0318 ENOG4107QN2 dihydrolipoyl dehydrogenase CDCE8392_0319 ENOG4105CFF transcriptional regulator CDCE8392_0322 ENOG4105E33 succinate dehydrogenase CDCE8392_0325 ENOG4106BRA Membrane CDCE8392_0327 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) CDCE8392_0329 ENOG4105F1A Pyruvate formate-lyase CDCE8392_0331 ENOG4105C6N Formate acetyltransferase CDCE8392_0335 ENOG4105KWG Pfam:DUF1696 CDCE8392_0336 ENOG4105CEY Amp-dependent synthetase and ligase CDCE8392_0337 ENOG4105CEY Amp-dependent synthetase and ligase CDCE8392_0340 ENOG4105BZU Histidine kinase CDCE8392_0349 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) CDCE8392_0350 ENOG4108RXW HAD-superfamily subfamily IB hydrolase CDCE8392_0354 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) CDCE8392_0355 ENOG4105D52 delta-aminolevulinic acid dehydratase CDCE8392_0362 ENOG4108RH7 phosphoglycerate mutase CDCE8392_0364 ENOG4107QIV Cytochrome c biogenesis protein CDCE8392_0366 ENOG4105CRE cytochrome C CDCE8392_0373 ENOG4107SIQ Naphthoate synthase CDCE8392_0374 ENOG4107TCW O-succinylbenzoate synthase CDCE8392_0376 ENOG4105BZF Glycosyl transferase (Group 1 CDCE8392_0377 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) CDCE8392_0378 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) CDCE8392_0379 ENOG4105P52 geranylgeranyl reductase CDCE8392_0386 ENOG4105DQ6 Transposase CDCE8392_0389 ENOG4105DSE periplasmic solute binding protein CDCE8392_0391 ENOG4105DIK (ABC) transporter CDCE8392_0392 ENOG4105CC5 ABC transporter CDCE8392_0408 ENOG4105BZU Histidine kinase CDCE8392_0409 ENOG4105WH1 Two component transcriptional regulator luxr family CDCE8392_0410 ENOG4105CJ1 ABC, transporter CDCE8392_0413 ENOG4108PJD permease CDCE8392_0434 ENOG4105C19 ABC transporter CDCE8392_0435 ENOG4107RBB ABC transporter, permease CDCE8392_0439 ENOG4105C44 Serine transporter CDCE8392_0440 ENOG4105EJQ L-serine dehydratase CDCE8392_0441 ENOG4105HDK L-asparaginase CDCE8392_0443 ENOG4105EPU Molybdenum cofactor synthesis domain protein CDCE8392_0450 ENOG4108IUE nitrate reductase beta subunit CDCE8392_0455 ENOG4105C6R Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) CDCE8392_0456 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) CDCE8392_0458 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) CDCE8392_0459 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) CDCE8392_0462 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component CDCE8392_0463 ENOG4105DEF Extracellular solute-binding protein, family 5 CDCE8392_0464 ENOG4107EJG GntR family transcriptional regulator CDCE8392_0467 ENOG4105CE4 GlcNAc 6-P deacetylase CDCE8392_0477 ENOG4105CG3 alpha amylase, catalytic region CDCE8392_0478 ENOG4105CG3 alpha amylase, catalytic region CDCE8392_0481 ENOG4105EG2 ABC transporter, permease CDCE8392_0484 ENOG4108IJ9 (ABC) transporter CDCE8392_0485 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) CDCE8392_0499 ENOG41090GG peptidase S8 and S53, subtilisin, kexin, sedolisin CDCE8392_0502 ENOG4105EC2 ftsk spoIIIe CDCE8392_0513 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) CDCE8392_0518 ENOG41080E2 ribosomal-protein-alanine acetyltransferase CDCE8392_0526 ENOG4107QVP Dehydrogenase CDCE8392_0527 ENOG4108HUF Transporter CDCE8392_0528 ENOG4105EHG Permease protein CDCE8392_0529 ENOG4108U1V ABC transporter, permease CDCE8392_0530 ENOG4105E0A ABC, transporter CDCE8392_0531 ENOG4105DUU IucA IucC family protein CDCE8392_0554 ENOG4108UMI ABC transporter, permease CDCE8392_0556 ENOG4105D01 (LipO)protein CDCE8392_0557 ENOG4105D01 (LipO)protein CDCE8392_0561 ENOG4105DSE periplasmic solute binding protein CDCE8392_0562 ENOG4105DIK (ABC) transporter CDCE8392_0563 ENOG4105CC5 ABC transporter CDCE8392_0568 ENOG4105DQ6 Transposase CDCE8392_0575 ENOG4105EHG Permease protein CDCE8392_0576 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) CDCE8392_0578 ENOG4108IQK o-acetylhomoserine CDCE8392_0579 ENOG4105E9K Isocitrate dehydrogenase CDCE8392_0580 ENOG4105F27 Major Facilitator CDCE8392_0583 ENOG4105C31 Tryptophanyl-tRNA synthetase CDCE8392_0584 ENOG4107H3J ribonuclease CDCE8392_0585 ENOG4105DZ1 carboxypeptidase CDCE8392_0588 ENOG4107SN7 NLP P60 protein CDCE8392_0592 ENOG4107RM1 amidohydrolase CDCE8392_0594 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) CDCE8392_0597 ENOG4108JIK carboxylase CDCE8392_0598 ENOG4105KHC sulfurtransferase CDCE8392_0599 ENOG4105D7Z glutathione synthase CDCE8392_0600 ENOG4105EXC Acyl-transferase CDCE8392_0603 ENOG4108RVA ribokinase CDCE8392_0604 ENOG4105ETE Transcriptional regulator (LacI family CDCE8392_0606 ENOG4105D8K carboxyl transferase CDCE8392_0608 ENOG4105D8K carboxyl transferase CDCE8392_0609 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase CDCE8392_0614 ENOG4105CQS hydrogenase expression formation protein HypD CDCE8392_0615 ENOG4105WRB Hydrogenase assembly chaperone hypC hupF CDCE8392_0616 ENOG4105C45 hydrogenase expression formation protein (HypE) CDCE8392_0618 ENOG4105WMM Probably plays a role in a hydrogenase nickel cofactor insertion step (By similarity) CDCE8392_0619 ENOG4107RSS Hydrogenase accessory protein HypB CDCE8392_0620 ENOG4105E3S small subunit CDCE8392_0621 ENOG4105DPX Hydrogenase, large subunit CDCE8392_0622 ENOG4105X7T Ni Fe-hydrogenase, b-type cytochrome subunit CDCE8392_0623 ENOG4108USZ hydrogenase CDCE8392_0624 ENOG4105WMM Probably plays a role in a hydrogenase nickel cofactor insertion step (By similarity) CDCE8392_0628 ENOG4107TB5 TRANSCRIPTIONal CDCE8392_0631 ENOG4105K51 Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) CDCE8392_0636 ENOG4105EIP mannose-6-phosphate isomerase CDCE8392_0642 ENOG4105CK6 Two component transcriptional regulator (Winged helix family CDCE8392_0643 ENOG4105BZU Histidine kinase CDCE8392_0646 ENOG4108S7Q sigma 54 modulation protein ribosomal protein S30ea CDCE8392_0653 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) CDCE8392_0654 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase CDCE8392_0655 ENOG4108RAV Conserved protein CDCE8392_0656 ENOG4108Z66 YbaK ebsC protein CDCE8392_0663 ENOG4105C1J atp-dependent rna helicase CDCE8392_0668 ENOG4105C4R Atp-dependent dna helicase CDCE8392_0669 ENOG4107SVH Potassium channel protein CDCE8392_0670 ENOG4105E09 nadh pyrophosphatase CDCE8392_0675 ENOG41063PX domain protein CDCE8392_0682 ENOG4105DZR Type I site-specific deoxyribonuclease CDCE8392_0687 ENOG4107QSA Oxaloacetate decarboxylase CDCE8392_0688 ENOG4107QX3 carboxylase CDCE8392_0690 ENOG4107QSA Oxaloacetate decarboxylase CDCE8392_0692 ENOG4107TK4 histidinol-phosphate phosphatase CDCE8392_0693 ENOG4107TK4 histidinol-phosphate phosphatase CDCE8392_0695 ENOG4105CFC Transporter CDCE8392_0697 ENOG4105CAK Cell division ATP-binding protein ftsE CDCE8392_0698 ENOG4107RYD Part of the ABC transporter FtsEX involved in cellular division (By similarity) CDCE8392_0702 ENOG41089UC methyltransferase, type 11 CDCE8392_0710 ENOG4105MS9 Resuscitation-promoting factor CDCE8392_0711 ENOG4105VEQ Cold shock protein CDCE8392_0715 ENOG4105C7N Xanthine uracil vitamin C permease CDCE8392_0716 ENOG4105FCS tRNA rRNA methyltransferase CDCE8392_0721 ENOG4105BZN citrate synthase CDCE8392_0722 ENOG41081K0 peptidylprolyl cis-trans isomerase CDCE8392_0724 ENOG4105CV8 reductase CDCE8392_0727 ENOG4107QN1 sodium solute CDCE8392_0729 ENOG4108WKN secreted protein CDCE8392_0739 ENOG4107QRT dEAD DEAH box helicase CDCE8392_0741 ENOG4108S0J Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized pyrimidines, such as thymine glycol, 5,6-dihydrouracil and 5,6-dihydrothymine. Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'- phosphates (By similarity) CDCE8392_0743 ENOG410901E Membrane CDCE8392_0758 ENOG4105EC0 Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity) CDCE8392_0766 ENOG4105ETX regulatoR CDCE8392_0767 ENOG41062D9 Histidine kinase CDCE8392_0768 ENOG4105C0H protease CDCE8392_0774 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase CDCE8392_0780 ENOG4105FF9 glycosyl transferase, family 39 CDCE8392_0781 ENOG4105C94 Transporter CDCE8392_0782 ENOG4108K88 Membrane CDCE8392_0785 ENOG4105F8V Hydrolase, tatD family CDCE8392_0786 ENOG4106839 domain protein CDCE8392_0789 ENOG4105C5H ABC transporter CDCE8392_0794 ENOG4105CSR polyphosphate kinase 2 CDCE8392_0796 ENOG410667J hydrolase CDCE8392_0805 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) CDCE8392_0809 ENOG4108IUM Glycogen debranching enzyme CDCE8392_0810 ENOG4105C5T Phosphoribosyl pyrophosphate synthase CDCE8392_0815 ENOG4105BZ1 (ABC) transporter CDCE8392_0816 ENOG4105BZ1 (ABC) transporter CDCE8392_0821 ENOG4105D5Q Arginine ornithine antiporter CDCE8392_0822 ENOG4105DXN mazG family CDCE8392_0834 ENOG4105T1M mycothiol conjugate amidase mca CDCE8392_0853 ENOG4105C8J )-transporter CDCE8392_0854 ENOG4105C3G gtp-binding protein CDCE8392_0855 ENOG4105CKW Inner membrane protein yedI CDCE8392_0859 ENOG4108JJB ABC transporter CDCE8392_0862 ENOG4108J59 Extracellular solute-binding protein, family 5 CDCE8392_0863 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component CDCE8392_0864 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component CDCE8392_0867 ENOG4108JJB ABC transporter CDCE8392_0869 ENOG4108TVX serine protease CDCE8392_0870 ENOG4105K89 arsenate reductase CDCE8392_0873 ENOG4105CI3 gtp-binding protein typa CDCE8392_0877 ENOG4108Z4U Ferredoxin CDCE8392_0883 ENOG4105C85 amino acid CDCE8392_0884 ENOG4105EJ3 Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2- amino-6-oxopimelate using succinyl-CoA (By similarity) CDCE8392_0885 ENOG4105C85 amino acid CDCE8392_0889 ENOG4105EEI dihydropteroate synthase CDCE8392_0890 ENOG4105C3Q Glycosyl transferase, family 2 CDCE8392_0895 ENOG4107FQX Alpha-acetolactate decarboxylase CDCE8392_0896 ENOG4107QPH glycogen) synthase CDCE8392_0899 ENOG4105DU6 RNA polymerase CDCE8392_0904 ENOG4105CJW magnesium transporter CDCE8392_0907 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 CDCE8392_0908 ENOG4105BZ1 (ABC) transporter CDCE8392_0912 ENOG4105F9E Shikimate 5-dehydrogenase CDCE8392_0913 ENOG4105EBR Carboxylesterase CDCE8392_0918 ENOG4105CK7 Sodium proline symporter CDCE8392_0921 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) CDCE8392_0923 ENOG4105M6F mutator MutT protein CDCE8392_0928 ENOG4105CK7 Sodium proline symporter CDCE8392_0929 ENOG4105C0D helicase CDCE8392_0933 ENOG4108YYC ycei family CDCE8392_0936 ENOG41080R8 Conserved Protein CDCE8392_0937 ENOG4107QR9 Iron-sulfur cluster binding protein CDCE8392_0938 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) CDCE8392_0939 ENOG4105DAA L-lactate CDCE8392_0941 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) CDCE8392_0942 ENOG4105D6E homoserine dehydrogenase CDCE8392_0945 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) CDCE8392_0945 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) CDCE8392_0951 ENOG4107UH5 it plays a direct role in the translocation of protons across the membrane (By similarity) CDCE8392_0952 ENOG4105ZA1 atp synthase CDCE8392_0964 ENOG4105E0A ABC, transporter CDCE8392_0965 ENOG4105TVJ transport system, permease CDCE8392_0966 ENOG4105DQ5 transport system permease protein CDCE8392_0967 ENOG4108MES Periplasmic binding protein CDCE8392_0972 ENOG4105DKW ABC transporter CDCE8392_0976 ENOG4105C10 Electron transfer flavoprotein CDCE8392_0978 ENOG4105C3J Cysteine desulfurase CDCE8392_0990 ENOG4105EHG Permease protein CDCE8392_0991 ENOG4105E0A ABC, transporter CDCE8392_0994 ENOG4105CTQ phosphohexokinase CDCE8392_0996 ENOG4105CPC Aldo Keto reductase CDCE8392_0998 ENOG4105CXD Specific inhibitor of chromosomal initiation of replication in vitro. Binds the three 13-mers in the origin (oriC) to block initiation of replication (By similarity) CDCE8392_0999 ENOG4105CHF Glutathione S-transferase CDCE8392_1004 ENOG4105C7K acetolactate synthase CDCE8392_1007 ENOG4105PGM cation diffusion facilitator family transporter CDCE8392_1014 ENOG4105ERH Fumarylacetoacetate hydrolase CDCE8392_1018 ENOG4105F9F transposase CDCE8392_1021 ENOG4105EYF MMPL domain protein CDCE8392_1025 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA CDCE8392_1035 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) CDCE8392_1036 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) CDCE8392_1037 ENOG4105DP4 dak2 domain fusion protein ylov CDCE8392_1038 ENOG4105CB5 ATP-dependent DNA helicase recG CDCE8392_1040 ENOG4106H78 methyltransferase CDCE8392_1044 ENOG4105E5Q amino acid AbC transporter CDCE8392_1047 ENOG4105F9F transposase CDCE8392_1050 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) CDCE8392_1051 ENOG4105CEE C4-dicarboxylate transporter CDCE8392_1052 ENOG4105CID antiterminator CDCE8392_1058 ENOG4105EEM helicase CDCE8392_1060 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) CDCE8392_1072 ENOG4105C8Y Acetylornithine aminotransferase CDCE8392_1077 ENOG4105W49 UPF0434 protein CDCE8392_1080 ENOG4105DSU hydrolase CDCE8392_1087 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) CDCE8392_1091 ENOG4105DUX Transporter CDCE8392_1092 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) CDCE8392_1095 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) CDCE8392_1098 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) CDCE8392_1099 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter CDCE8392_1100 ENOG4108BSC Methyltransferase CDCE8392_1101 ENOG4108SEA Esterase CDCE8392_1111 ENOG4105C37 (CBS) domain CDCE8392_1112 ENOG4105C1J atp-dependent rna helicase CDCE8392_1113 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) CDCE8392_1115 ENOG4105D7N magnesium and cobalt transport protein CorA CDCE8392_1123 ENOG4105C09 Bile acid CDCE8392_1128 ENOG4106N3V dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83) CDCE8392_1129 ENOG4107R05 Transfers the fatty acyl group on membrane lipoproteins (By similarity) CDCE8392_1131 ENOG4105CTK cobaltochelatase, cobn subunit CDCE8392_1132 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) CDCE8392_1141 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) CDCE8392_1142 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) CDCE8392_1144 ENOG4107TMB Transcriptional regulator CDCE8392_1148 ENOG4105E5F proteasome CDCE8392_1151 ENOG4105DFM M18 family aminopeptidase CDCE8392_1154 ENOG4108IJ0 Aspartate ammonia-lyase CDCE8392_1155 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter CDCE8392_1156 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter CDCE8392_1160 ENOG4105C3R Methionine synthase CDCE8392_1166 ENOG4108V1U phospholipid-binding protein CDCE8392_1174 ENOG4105KHC sulfurtransferase CDCE8392_1185 ENOG4105ZXU NLP P60 protein CDCE8392_1191 ENOG4105CAG UPF0210 protein CDCE8392_1192 ENOG4105C5H ABC transporter CDCE8392_1193 ENOG4105VG1 fes assembly suf system protein CDCE8392_1194 ENOG4108UNV SUF system FeS assembly protein, NifU family CDCE8392_1195 ENOG4105C9B Cysteine desulfurase CDCE8392_1196 ENOG4105C3K feS assembly ATPase SufC CDCE8392_1197 ENOG4105JRK feS assembly protein SufD CDCE8392_1200 ENOG4107JC6 Membrane CDCE8392_1201 ENOG4105CJ1 ABC, transporter CDCE8392_1205 ENOG4105CV1 Transketolase (EC 2.2.1.1) CDCE8392_1206 ENOG4107QQX Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) CDCE8392_1213 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase CDCE8392_1215 ENOG4105CHW UPF0052 protein CDCE8392_1226 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) CDCE8392_1234 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain CDCE8392_1236 ENOG4105CD3 dihydroorotase CDCE8392_1242 ENOG4105DC7 peptidase M24 CDCE8392_1247 ENOG4105E2X shikimate dehydrogenase CDCE8392_1260 ENOG4105EJQ L-serine dehydratase CDCE8392_1262 ENOG4105C5X domain protein CDCE8392_1263 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) CDCE8392_1267 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) CDCE8392_1270 ENOG4107RTU Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) CDCE8392_1278 ENOG4105C29 acyl-CoA thioesterase CDCE8392_1283 ENOG4105D4K integrase catalytic CDCE8392_1299 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) CDCE8392_1301 ENOG4105E2K Glycosyl transferase (Group 1 CDCE8392_1302 ENOG4107YQ3 lipid a biosynthesis lauroyl acyltransferase CDCE8392_1306 ENOG4105DBE peroxidase CDCE8392_1310 ENOG4105WCJ ec 1.1.1.193 CDCE8392_1311 ENOG4105E0X reductase CDCE8392_1312 ENOG4107JTW chlorite dismutase CDCE8392_1338 ENOG4105D3R alkyl hydroperoxide reductase CDCE8392_1339 ENOG4105C5Q Transcriptional regulator CDCE8392_1341 ENOG4105CQ7 ATP-dependent helicase CDCE8392_1346 ENOG4105E98 transcriptional regulator DeoR family CDCE8392_1347 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) CDCE8392_1348 ENOG4105E98 transcriptional regulator DeoR family CDCE8392_1353 ENOG4105KRI phosphocarrier protein (HPr CDCE8392_1355 ENOG4108UZX fmn reductase CDCE8392_1356 ENOG4105C2W permease CDCE8392_1357 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) CDCE8392_1360 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) CDCE8392_1363 ENOG4105C99 atpase involved in dna repair CDCE8392_1371 ENOG4107ZYJ bioY protein CDCE8392_1372 ENOG4108JJB ABC transporter CDCE8392_1373 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) CDCE8392_1375 ENOG4105WBV Transcriptional regulator CDCE8392_1376 ENOG4105CEV competence damage-inducible protein CDCE8392_1382 ENOG4105CN5 Metallo-Beta-Lactamase CDCE8392_1393 ENOG4107QMU Mate efflux family protein CDCE8392_1395 ENOG4105SFS phosphoesterase RecJ domain protein CDCE8392_1403 ENOG4107XFJ UPF0246 protein CDCE8392_1404 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) CDCE8392_1405 ENOG4105CNG UPF0061 protein CDCE8392_1406 ENOG4105CKI cobalamin synthesis protein CDCE8392_1416 ENOG4105CJN penicillin-binding protein CDCE8392_1418 ENOG4105DZP Membrane-associated zinc metalloprotease CDCE8392_1420 ENOG41068X0 Protein of unknown function (DUF2631) CDCE8392_1429 ENOG4108IYT Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) CDCE8392_1431 ENOG4105C0P Mg chelatase subunit ChlI CDCE8392_1435 ENOG4107QYR Signal peptidase i CDCE8392_1443 ENOG4105E1P Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity) CDCE8392_1455 ENOG4107R37 Glutamate dehydrogenase CDCE8392_1456 ENOG4105BZW Glycerate kinase CDCE8392_1461 ENOG4105CA9 Pyruvate kinase CDCE8392_1463 ENOG4105DK0 Indole-3-glycerol phosphate synthase CDCE8392_1467 ENOG4108MWI inositol mono-phosphatase CDCE8392_1486 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein CDCE8392_1487 ENOG4105C7B Threonine dehydratase CDCE8392_1489 ENOG4105FR1 rard protein CDCE8392_1495 ENOG4105HDK L-asparaginase CDCE8392_1498 ENOG4107VQS DivIVA family CDCE8392_1500 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) CDCE8392_1501 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase CDCE8392_1502 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) CDCE8392_1503 ENOG4108UFP Essential cell division protein (By similarity) CDCE8392_1510 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) CDCE8392_1511 ENOG4105CJN penicillin-binding protein CDCE8392_1520 ENOG41072RD Membrane CDCE8392_1521 ENOG4105KYH transcriptional regulatory protein CDCE8392_1523 ENOG4105C7V phospho-2-dehydro-3-deoxyheptonate aldolase CDCE8392_1526 ENOG4105DKQ ROK family CDCE8392_1527 ENOG4105JNK Glycosyl transferase (Group 1 CDCE8392_1529 ENOG4105K4H Nlp p60 protein CDCE8392_1539 ENOG4108YZT Adenosylcobinamide kinase CDCE8392_1540 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) CDCE8392_1542 ENOG4105CM2 brancheD-chain amino acid aminotransferase CDCE8392_1550 ENOG4105C5F glutamine synthetase CDCE8392_1553 ENOG4105D3Y Na H antiporter CDCE8392_1559 ENOG4105D98 threonine synthase CDCE8392_1564 ENOG4105C5F glutamine synthetase CDCE8392_1574 ENOG4105CVJ phosphoglycerate mutase CDCE8392_1576 ENOG4105EGD dinuclear metal center protein, YbgI family CDCE8392_1581 ENOG4105DH2 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity) CDCE8392_1583 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) CDCE8392_1587 ENOG4108YIQ Alpha beta hydrolase CDCE8392_1592 ENOG4105EN6 Membrane CDCE8392_1604 ENOG4105D9H Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) CDCE8392_1609 ENOG4106DBE Involved in DNA repair and RecF pathway recombination (By similarity) CDCE8392_1625 ENOG4105DGW oligopeptidase A CDCE8392_1626 ENOG4105EBR Carboxylesterase CDCE8392_1632 ENOG4105BZ1 (ABC) transporter CDCE8392_1633 ENOG4105C87 Aminotransferase class I and II CDCE8392_1634 ENOG4105CWM branched-chain amino acid transport system II carrier protein CDCE8392_1635 ENOG4105DEN Luciferase family CDCE8392_1636 ENOG4105C94 Transporter CDCE8392_1637 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein CDCE8392_1639 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component CDCE8392_1640 ENOG4108JQ6 ABC transporter CDCE8392_1643 ENOG4105DFA alanine racemase domain protein CDCE8392_1646 ENOG4107QMW pyridine nucleotide-disulfide oxidoreductase CDCE8392_1654 ENOG4105D85 methylase CDCE8392_1668 ENOG4107Z8D degv family CDCE8392_1669 ENOG4105CVJ phosphoglycerate mutase CDCE8392_1671 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) CDCE8392_1677 ENOG4105C03 ribonuclease CDCE8392_1680 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase CDCE8392_1692 ENOG4105MC2 DSBA oxidoreductase CDCE8392_1694 ENOG4105D8X mechanosensitive ion channel CDCE8392_1700 ENOG4108PNC copper resistance CDCE8392_1701 ENOG4105D22 carbon starvation protein CDCE8392_1704 ENOG4105DQ6 Transposase CDCE8392_1706 ENOG4105D3Z quinone oxidoreductase, yhdh yhfp family CDCE8392_1707 ENOG4105EMU Dehydrogenase CDCE8392_1709 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) CDCE8392_1710 ENOG4107UBC ErfK ybiS ycfS ynhG family protein CDCE8392_1717 ENOG4105IBS Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) CDCE8392_1720 ENOG4105XM7 Lipoprotein lprD CDCE8392_1724 ENOG4108RQ5 Beta-lactamase domain-containing protein CDCE8392_1727 ENOG4105KXX peptidase s58 dmpa CDCE8392_1730 ENOG4107RKP Nicotinate phosphoribosyltransferase CDCE8392_1737 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) CDCE8392_1740 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) CDCE8392_1741 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) CDCE8392_1742 ENOG4105WAZ (Glutaredoxin-like protein) NrdH CDCE8392_1746 ENOG4107RA1 nh(3)-dependent nad( ) synthetase CDCE8392_1755 ENOG4107QIX Phosphoglucomutase (EC 5.4.2.2 CDCE8392_1758 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) CDCE8392_1759 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) CDCE8392_1763 ENOG4105C6T cysteine synthase CDCE8392_1764 ENOG4105D7W serine acetyltransferase CDCE8392_1767 ENOG4105E0A ABC, transporter CDCE8392_1769 ENOG4105DQ5 transport system permease protein CDCE8392_1790 ENOG4105C4M (Ubiquinol oxidase) subunit I CDCE8392_1791 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii CDCE8392_1792 ENOG4108JJ9 ABC, transporter CDCE8392_1801 ENOG4105CBD Diacylglycerol kinase CDCE8392_1804 ENOG4106XY2 Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity) CDCE8392_1811 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) CDCE8392_1812 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) CDCE8392_1815 ENOG4108V06 Glutathione peroxidase CDCE8392_1818 ENOG4105C83 adenylosuccinate lyase CDCE8392_1819 ENOG4105CHM Aminotransferase CDCE8392_1820 ENOG4107ZYR domain protein CDCE8392_1822 ENOG4105C12 Phosphoribosylglycinamide synthetase CDCE8392_1823 ENOG4107ZUX Histidine triad (HIT) protein CDCE8392_1824 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) CDCE8392_1825 ENOG4105GR3 Histidine kinase CDCE8392_1826 ENOG4105CK6 Two component transcriptional regulator (Winged helix family CDCE8392_1828 ENOG4105C57 major facilitator superfamily CDCE8392_1831 ENOG4105C7K acetolactate synthase CDCE8392_1837 ENOG4108K4C ec 3.1.3.12 CDCE8392_1839 ENOG4105C2N RNA methyltransferase TrmH family group 3 CDCE8392_1843 ENOG4108VJ1 Transcriptional regulator (CarD family CDCE8392_1846 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) CDCE8392_1848 ENOG4108V9Q carbonic anhydrase CDCE8392_1852 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit CDCE8392_1855 ENOG4105E5G Alpha beta hydrolase fold CDCE8392_1857 ENOG4105KG3 cytidine deaminase CDCE8392_1858 ENOG4105D9N nucleoside CDCE8392_1861 ENOG4105CRK lysyL-tRNA synthetase CDCE8392_1870 ENOG4108M15 ABC transporter CDCE8392_1872 ENOG410836F Transposase CDCE8392_1876 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) CDCE8392_1884 ENOG4105EUJ GTP cyclohydrolase i CDCE8392_1885 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) CDCE8392_1886 ENOG4108UGV hypoxanthine phosphoribosyltransferase CDCE8392_1889 ENOG4105F0N pyrophosphate phospho-hydrolase CDCE8392_1890 ENOG4105WZW rhodanese family CDCE8392_1899 ENOG4105CSR polyphosphate kinase 2 CDCE8392_1919 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) CDCE8392_1921 ENOG4105CGK Exodeoxyribonuclease III CDCE8392_1922 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) CDCE8392_1930 ENOG4107Q25 Serine Threonine protein kinase CDCE8392_1932 ENOG4108IJ2 phosphate acetyltransferase CDCE8392_1934 ENOG4108HH9 Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR CDCE8392_1935 ENOG4105DYA Acts on guanine, xanthine and to a lesser extent hypoxanthine (By similarity) CDCE8392_1938 ENOG4105F9F transposase CDCE8392_1959 ENOG4105J1P transposase, IS3 IS911 family protein CDCE8392_1964 ENOG4105C0W non-ribosomal peptide synthetase CDCE8392_1966 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase CDCE8392_1967 ENOG4105C0W non-ribosomal peptide synthetase CDCE8392_1970 ENOG4108JJB ABC transporter CDCE8392_1975 ENOG4108UW5 maltose o-acetyltransferase CDCE8392_1981 ENOG4105F9F transposase CDCE8392_1982 ENOG4105DQ6 Transposase CDCE8392_1984 ENOG4105F9F transposase CDCE8392_1988 ENOG4107RCW fructose-bisphosphate aldolase CDCE8392_1994 ENOG4105DRP amino acid AbC transporter CDCE8392_1996 ENOG4108Q1T ABC transporter CDCE8392_1998 ENOG4105MS9 Resuscitation-promoting factor CDCE8392_1999 ENOG4105CJ1 ABC, transporter CDCE8392_2009 ENOG4105C26 Dehydrogenase CDCE8392_2012 ENOG410836F Transposase CDCE8392_2013 ENOG4105KNI merR family transcriptional Regulator CDCE8392_2017 ENOG4107RHT methyl-accepting chemotaxis sensory transducer with Pas Pac sensor CDCE8392_2020 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component CDCE8392_2029 ENOG4107QIK phosphoribosylformylglycinamidine synthase CDCE8392_2030 ENOG4105CHU acetyl-coa acetyltransferase CDCE8392_2031 ENOG4105CHU acetyl-coa acetyltransferase CDCE8392_2032 ENOG4105CHU acetyl-coa acetyltransferase CDCE8392_2033 ENOG4105CHU acetyl-coa acetyltransferase CDCE8392_2035 ENOG4105E0A ABC, transporter CDCE8392_2036 ENOG4105TVJ transport system, permease CDCE8392_2037 ENOG4105DQ5 transport system permease protein CDCE8392_2042 ENOG4105DF6 Fe-S oxidoreductase CDCE8392_2047 ENOG4105CRK lysyL-tRNA synthetase CDCE8392_2050 ENOG4105C6Y Udp-glucose 6-dehydrogenase CDCE8392_2054 ENOG4105WXW Antirepressor CDCE8392_2058 ENOG4105BZ1 (ABC) transporter CDCE8392_2061 ENOG4105C0W non-ribosomal peptide synthetase CDCE8392_2061 ENOG4105C0W non-ribosomal peptide synthetase CDCE8392_2061 ENOG4105C0W non-ribosomal peptide synthetase CDCE8392_2063 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component CDCE8392_2065 ENOG4108JJB ABC transporter CDCE8392_2066 ENOG4105CSH Transporter CDCE8392_2068 ENOG4105C2C drug resistance transporter, Bcr CflA CDCE8392_2073 ENOG41073B4 coagulation factor 5 8 type domain-containing protein CDCE8392_2074 ENOG4105EXC Acyl-transferase CDCE8392_2075 ENOG41090MF Protein of unknown function (DUF3068) CDCE8392_2077 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) CDCE8392_2078 ENOG4108M6P methyltransferase CDCE8392_2089 ENOG4105D8K carboxyl transferase CDCE8392_2094 ENOG4107YB1 Trehalose corynomycolyl transferase CDCE8392_2096 ENOG4105DQ6 Transposase CDCE8392_2099 ENOG4107ISF Involved in the biosynthesis of the arabinogalactan (AG) region of the mycolylarabinogalactan-peptidoglycan (mAGP) complex, an essential component the mycobacterial cell wall. Catalyzes the transfer of arabinofuranosyl (Araf) residues residue from the sugar donor beta-D-arabinofuranosyl-1-monophosphoryldecaprenol (DPA) to the arabinan domain to form terminal beta-(1- 2)-linked Araf residues, which marks the end point for AG arabinan biosynthesis before decoration with mycolic acids CDCE8392_2100 ENOG4106YN8 Prenyltransferase CDCE8392_2102 ENOG410602S Transferase CDCE8392_2103 ENOG410841Q phosphoesterase PA-phosphatase related protein CDCE8392_2104 ENOG4105C26 Dehydrogenase CDCE8392_2105 ENOG4105C94 Transporter CDCE8392_2110 ENOG4108JJB ABC transporter CDCE8392_2120 ENOG4105E0A ABC, transporter CDCE8392_2122 ENOG4105TVJ transport system, permease CDCE8392_2123 ENOG4105DQ5 transport system permease protein CDCE8392_2124 ENOG4105DQ5 transport system permease protein CDCE8392_2126 ENOG4108JQ0 Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) CDCE8392_2127 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) CDCE8392_2128 ENOG4105C6V Glycerol-3-phosphate dehydrogenase CDCE8392_2129 ENOG4105E9Q Acyl-transferase CDCE8392_2130 ENOG4108AZI Catalyzes the hydrolysis of 4-amino-2-methyl-5- hydroxymethylpyrimidine pyrophosphate (HMP-PP) to 4-amino-2- methyl-5-hydroxymethylpyrimidine phosphate (HMP-P) (By similarity) CDCE8392_2132 ENOG4105FDP GntR family transcriptional regulator CDCE8392_2137 ENOG4105CQC Prephenate dehydratase CDCE8392_2140 ENOG4105DSQ Nitric oxide reductase CDCE8392_2141 ENOG4108KGH TRANSCRIPTIONal CDCE8392_2142 ENOG4105BZG amino acid carrier protein CDCE8392_2143 ENOG4105EXC Acyl-transferase CDCE8392_2147 ENOG4105MN5 HAD-superfamily hydrolase subfamily IA variant 3 CDCE8392_2153 ENOG4108YYH Nadph-dependent fmn reductase CDCE8392_2154 ENOG4108VJY integral membrane protein CDCE8392_2158 ENOG4105WH1 Two component transcriptional regulator luxr family CDCE8392_2160 ENOG4105CXY transporter CDCE8392_2162 ENOG4108RN7 integral membrane protein CDCE8392_2163 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins CDCE8392_2168 ENOG4105D3G Pseudouridine synthase CDCE8392_2170 ENOG4105C2J ABC transporter CDCE8392_2171 ENOG4105C6F GntR Family Transcriptional Regulator CDCE8392_2175 ENOG41080RH Thioredoxin CDCE8392_2178 ENOG41079KZ Major Facilitator Superfamily CDCE8392_2181 ENOG4107YH6 single-stranded DNA-binding protein CDCE8392_2185 ENOG4105BZ4 penicillin-binding protein CDCE8392_2191 ENOG4105CB5 ATP-dependent DNA helicase recG CDCE8392_2193 ENOG4105DQR SNARE associated Golgi CDCE8392_2194 ENOG4105DPV During stationary phase, binds the chromosome non- specifically, forming a highly ordered and stable dps-DNA co- crystal within which chromosomal DNA is condensed and protected from diverse damages. It protects DNA from oxidative damage by sequestering intracellular Fe(2 ) ion and storing it in the form of Fe(3 ) oxyhydroxide mineral, which can be released after reduction. One hydrogen peroxide oxidizes two Fe(2 ) ions, which prevents hydroxyl radical production by the Fenton reaction CDCE8392_2199 ENOG4105DSM The key enzymatic reactions in nitrogen fixation are catalyzed by the nitrogenase complex, which has 2 components the iron protein and the molybdenum-iron protein (By similarity) CDCE8392_2202 ENOG4105CB5 ATP-dependent DNA helicase recG CDCE8392_2204 ENOG4105DZR Type I site-specific deoxyribonuclease CDCE8392_2206 ENOG4105CVR type I restriction-modification system CDCE8392_2213 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) CDCE8392_2214 ENOG4105I2S Part of the ABC transporter complex hrt involved in hemin import. Responsible for the translocation of the substrate across the membrane (By similarity) CDCE8392_2215 ENOG4105ENE Histidine kinase CDCE8392_2216 ENOG4105WH1 Two component transcriptional regulator luxr family CDCE8392_2218 ENOG4105ECB domain protein CDCE8392_2219 ENOG4105C26 Dehydrogenase CDCE8392_2222 ENOG4105CMT Dihydroxyacetone kinase CDCE8392_2223 ENOG4108UTZ Dihydroxyacetone kinase CDCE8392_2233 ENOG4105D6J arsenicaL-resistance protein CDCE8392_2241 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) CDCE8392_2242 ENOG4105CRQ synthase (Component I) CDCE8392_2243 ENOG4105RGK anthranilate synthase component ii CDCE8392_2245 ENOG4105DK0 Indole-3-glycerol phosphate synthase CDCE8392_2246 ENOG4105WD1 Membrane CDCE8392_2249 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) CDCE8392_2252 ENOG4105DHU Bile acid CDCE8392_2255 ENOG4108UMN azlc family CDCE8392_2256 ENOG4108UJU UPF0301 protein CDCE8392_2257 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate CDCE8392_2262 ENOG4105C3M thioredoxin reductase CDCE8392_2263 ENOG4105K63 Thioredoxin CDCE8392_2264 ENOG4108E1C hydrolase CDCE8392_2266 ENOG4107QJE Chromosome Partitioning Protein