locus-tag class description Cp267_0003 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) Cp267_0006 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) Cp267_0011 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) Cp267_0017 ENOG4107SDZ Galactoside transport system permease protein mglC Cp267_0018 ENOG4105C2J ABC transporter Cp267_0033 ENOG4105E0A ABC, transporter Cp267_0034 ENOG4105TVJ transport system, permease Cp267_0035 ENOG4105DQ5 transport system permease protein Cp267_0036 ENOG4108MES Periplasmic binding protein Cp267_0037 ENOG4105XBB septation inhibitor protein Cp267_0038 ENOG4108DT4 serine threonine protein kinase Cp267_0040 ENOG4105CJN penicillin-binding protein Cp267_0044 ENOG4105TV9 FHA Domain-Containing protein Cp267_0044 ENOG4105TV9 FHA Domain-Containing protein Cp267_0049 ENOG4105E0A ABC, transporter Cp267_0050 ENOG4105EHG Permease protein Cp267_0051 ENOG4105CJW magnesium transporter Cp267_0053 ENOG4105CG3 alpha amylase, catalytic region Cp267_0059 ENOG4105K6V RNA polymerase Cp267_0066 ENOG4108IJ8 ABC transporter Cp267_0068 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) Cp267_0070 ENOG41066NP positive regulation by symbiont of host immune response Cp267_0072 ENOG4105FYV Amp nucleosidase Cp267_0074 ENOG4107YXZ hydrolase, family 25 Cp267_0080 ENOG4108Z0R Transferase Cp267_0083 ENOG4108URH decarboxylase Cp267_0085 ENOG4105K56 Transcriptional regulator Cp267_0088 ENOG4108KK1 membrane protein AbrB duplication Cp267_0090 ENOG4105EJ9 Membrane Cp267_0091 ENOG4106ETB IIa component Cp267_0093 ENOG4105CQ7 ATP-dependent helicase Cp267_0094 ENOG4105CF1 Alkylated DNA repair protein Cp267_0095 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) Cp267_0097 ENOG4105K8R UPF0145 protein Cp267_0098 ENOG410848D S4 domain protein YaaA Cp267_0103 ENOG4108JQ0 Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) Cp267_0104 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) Cp267_0106 ENOG4105C9K Endothelin-converting enzyme 1 Cp267_0110 ENOG4105J1Z Arabinosyltransferase Cp267_0111 ENOG4108K7T Involved in the biosynthesis of the arabinogalactan (AG) region of the mycolylarabinogalactan-peptidoglycan (mAGP) complex, an essential component the mycobacterial cell wall. Catalyzes the addition of the first key arabinofuranosyl (Araf) residue from the sugar donor beta-D-arabinofuranosyl-1-monophosphoryldecaprenol (DPA) on the C-5 of a 6-linked galactofuranosyl (Galf) of the galactan domain, thus 'priming' the galactan for further elaboration by other arabinofuranosyltransferases Cp267_0112 ENOG4108RG3 short-chain dehydrogenase reductase Cp267_0113 ENOG4105IQ5 FAD linked oxidase domain protein Cp267_0119 ENOG4108MKI Glycosyl transferase, family 2 Cp267_0120 ENOG4107SIG periplasmic solute binding protein Cp267_0121 ENOG4105DIK (ABC) transporter Cp267_0122 ENOG4107RPQ ABC transporter Cp267_0123 ENOG4107RBD ABC, transporter Cp267_0124 ENOG4105DSE periplasmic solute binding protein Cp267_0129 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein Cp267_0131 ENOG4105C8P )-transporter Cp267_0135 ENOG4105DSQ Nitric oxide reductase Cp267_0137 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family Cp267_0140 ENOG4105EVN Prephenate dehydrogenase Cp267_0142 ENOG4108Z6B deaminase Cp267_0143 ENOG4105EYF MMPL domain protein Cp267_0144 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) Cp267_0146 ENOG4105C6Z Gluconate Cp267_0147 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family Cp267_0148 ENOG4105CPQ Dehydrogenase Cp267_0149 ENOG4105CHR reductase Cp267_0151 ENOG4105XT2 Transcriptional regulator Cp267_0156 ENOG4105C6Z Gluconate Cp267_0157 ENOG4105ZXK Dehydrogenase Cp267_0160 ENOG4105ERH Fumarylacetoacetate hydrolase Cp267_0163 ENOG4105F1K Glutamine amidotransferase Cp267_0164 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) Cp267_0166 ENOG4108DBC nitroreductase Cp267_0168 ENOG4107RHR regulatoR Cp267_0169 ENOG4105D3A purine nucleoside phosphorylase DeoD-type Cp267_0172 ENOG4107QSU Phosphoglucomutase phosphomannomutase alpha beta alpha domain Cp267_0175 ENOG4105DUY Ser-Asp rich fibrinogen-binding, bone sialoprotein-binding protein Cp267_0178 ENOG4105PP6 Membrane Cp267_0179 ENOG4105CFH Aspartokinase Cp267_0181 ENOG4105DUY Ser-Asp rich fibrinogen-binding, bone sialoprotein-binding protein Cp267_0184 ENOG4105CH6 catalase Cp267_0193 ENOG4107QKW extracellular solute-binding protein family 1 Cp267_0194 ENOG4105CXY transporter Cp267_0195 ENOG4105CK6 Two component transcriptional regulator (Winged helix family Cp267_0196 ENOG4105BZU Histidine kinase Cp267_0200 ENOG4108JPZ Monovalent cation H antiporter subunit D Cp267_0202 ENOG4105D65 subunit l Cp267_0204 ENOG4108NJC Cp267_0206 ENOG4108IUX (ABC) transporter Cp267_0214 ENOG4105BZ4 penicillin-binding protein Cp267_0215 ENOG4105N0U Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) Cp267_0219 ENOG4105IJJ transcriptional regulator, crp fnr family Cp267_0223 ENOG4105P8F nudix hydrolase Cp267_0237 ENOG4108I5C dEAD DEAH box helicase Cp267_0239 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) Cp267_0240 ENOG4105EPD Oligopeptide transporter, Opt family Cp267_0242 ENOG4107QRG dna polymerase iii Cp267_0244 ENOG4105CEY Amp-dependent synthetase and ligase Cp267_0246 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) Cp267_0248 ENOG4105C1B dTDP-glucose 4-6-dehydratase Cp267_0254 ENOG4107QN2 dihydrolipoyl dehydrogenase Cp267_0255 ENOG4105CFF transcriptional regulator Cp267_0258 ENOG4105E33 succinate dehydrogenase Cp267_0260 ENOG4106BRA Membrane Cp267_0262 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) Cp267_0266 ENOG4105C6N Formate acetyltransferase Cp267_0270 ENOG4105CEY Amp-dependent synthetase and ligase Cp267_0273 ENOG4105BZU Histidine kinase Cp267_0274 ENOG4105CK6 Two component transcriptional regulator (Winged helix family Cp267_0278 ENOG4105II7 pyrroline-5-carboxylate reductase Cp267_0282 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) Cp267_0284 ENOG4108RXW HAD-superfamily subfamily IB hydrolase Cp267_0288 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) Cp267_0291 ENOG4105C59 p-type ATPase Cp267_0293 ENOG4105C1Q protoporphyrinogen oxidase Cp267_0296 ENOG4108RH7 phosphoglycerate mutase Cp267_0298 ENOG4107QIV Cytochrome c biogenesis protein Cp267_0300 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) Cp267_0303 ENOG4105EHG Permease protein Cp267_0304 ENOG4105CRE cytochrome C Cp267_0310 ENOG4105CEE C4-dicarboxylate transporter Cp267_0311 ENOG4107TCW O-succinylbenzoate synthase Cp267_0314 ENOG4105BZF Glycosyl transferase (Group 1 Cp267_0316 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) Cp267_0317 ENOG4105P52 geranylgeranyl reductase Cp267_0319 ENOG410683Z Preprotein translocase SecE subunit Cp267_0324 ENOG4105CTZ aminopeptidase c Cp267_0325 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase Cp267_0329 ENOG4105DSE periplasmic solute binding protein Cp267_0331 ENOG4105DIK (ABC) transporter Cp267_0332 ENOG4105CC5 ABC transporter Cp267_0337 ENOG4105BZU Histidine kinase Cp267_0338 ENOG4105WH1 Two component transcriptional regulator luxr family Cp267_0340 ENOG4105CJ1 ABC, transporter Cp267_0343 ENOG4108PJD permease Cp267_0358 ENOG4105VBF alkaline shock protein Cp267_0359 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) Cp267_0380 ENOG4105C44 Serine transporter Cp267_0381 ENOG4105EJQ L-serine dehydratase Cp267_0383 ENOG4105HDK L-asparaginase Cp267_0384 ENOG4105YVM Phosphoesterase, PA-phosphatase related Cp267_0394 ENOG4105EG2 ABC transporter, permease Cp267_0398 ENOG4108IJ9 (ABC) transporter Cp267_0399 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) Cp267_0409 ENOG4108ZT0 50S ribosomal protein l17 Cp267_0415 ENOG4105EC2 ftsk spoIIIe Cp267_0427 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) Cp267_0441 ENOG4108VT4 Cp267_0443 ENOG4107QVP Dehydrogenase Cp267_0452 ENOG4108UMI ABC transporter, permease Cp267_0454 ENOG4105D01 (LipO)protein Cp267_0456 ENOG4105D01 (LipO)protein Cp267_0460 ENOG4105DSE periplasmic solute binding protein Cp267_0461 ENOG4105DIK (ABC) transporter Cp267_0462 ENOG4107RBD ABC, transporter Cp267_0463 ENOG4107RPQ ABC transporter Cp267_0464 ENOG4107R5H iron (metal) dependent repressor, dtxr family Cp267_0465 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) Cp267_0466 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) Cp267_0473 ENOG4105DQ5 transport system permease protein Cp267_0474 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) Cp267_0476 ENOG4108IQK o-acetylhomoserine Cp267_0477 ENOG4105E9K Isocitrate dehydrogenase Cp267_0478 ENOG4105F27 Major Facilitator Cp267_0479 ENOG4108Z5V transcriptional regulator, merr family Cp267_0482 ENOG4105C31 Tryptophanyl-tRNA synthetase Cp267_0483 ENOG4107H3J ribonuclease Cp267_0484 ENOG4105DZ1 carboxypeptidase Cp267_0491 ENOG4107QSU Phosphoglucomutase phosphomannomutase alpha beta alpha domain Cp267_0492 ENOG4107RM1 amidohydrolase Cp267_0494 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) Cp267_0497 ENOG4108JIK carboxylase Cp267_0498 ENOG4105KHC sulfurtransferase Cp267_0500 ENOG4105D7Z glutathione synthase Cp267_0501 ENOG4105EXC Acyl-transferase Cp267_0503 ENOG4107WR6 Maf-like protein Cp267_0504 ENOG4108RVA ribokinase Cp267_0505 ENOG4105ETE Transcriptional regulator (LacI family Cp267_0507 ENOG4105D8K carboxyl transferase Cp267_0508 ENOG4105D8K carboxyl transferase Cp267_0510 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase Cp267_0521 ENOG4107TB5 TRANSCRIPTIONal Cp267_0527 ENOG4105K51 Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) Cp267_0532 ENOG4105EIP mannose-6-phosphate isomerase Cp267_0538 ENOG4105CK6 Two component transcriptional regulator (Winged helix family Cp267_0539 ENOG4105BZU Histidine kinase Cp267_0542 ENOG4108S7Q sigma 54 modulation protein ribosomal protein S30ea Cp267_0550 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase Cp267_0551 ENOG4108RAV Conserved protein Cp267_0552 ENOG4108Z66 YbaK ebsC protein Cp267_0559 ENOG4105C1J atp-dependent rna helicase Cp267_0564 ENOG4105C4R Atp-dependent dna helicase Cp267_0566 ENOG4105E09 nadh pyrophosphatase Cp267_0571 ENOG41063PX domain protein Cp267_0579 ENOG4108F3G Type I restriction-modification system, R subunit Cp267_0593 ENOG4105C85 amino acid Cp267_0594 ENOG4107QSA Oxaloacetate decarboxylase Cp267_0595 ENOG4107QX3 carboxylase Cp267_0597 ENOG4107QSA Oxaloacetate decarboxylase Cp267_0599 ENOG4107TK4 histidinol-phosphate phosphatase Cp267_0600 ENOG4107TK4 histidinol-phosphate phosphatase Cp267_0603 ENOG4105CFC Transporter Cp267_0605 ENOG4105CAK Cell division ATP-binding protein ftsE Cp267_0606 ENOG4107RYD Part of the ABC transporter FtsEX involved in cellular division (By similarity) Cp267_0609 ENOG4107B2H carbonic anhydrase Cp267_0612 ENOG4105CM4 permease protein Cp267_0613 ENOG4108IPW abc transporter atp-binding protein Cp267_0617 ENOG4105CFI type iii restriction protein res subunit Cp267_0619 ENOG4105MS9 Resuscitation-promoting factor Cp267_0626 ENOG4105C7N Xanthine uracil vitamin C permease Cp267_0627 ENOG4105FCS tRNA rRNA methyltransferase Cp267_0632 ENOG4105BZN citrate synthase Cp267_0633 ENOG41081K0 peptidylprolyl cis-trans isomerase Cp267_0638 ENOG4105CV8 reductase Cp267_0639 ENOG4108VUG Enoyl-CoA hydratase Cp267_0641 ENOG4107QN1 sodium solute Cp267_0642 ENOG4108WKN secreted protein Cp267_0646 ENOG4107QI1 Mate efflux family protein Cp267_0651 ENOG4108J59 Extracellular solute-binding protein, family 5 Cp267_0652 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component Cp267_0654 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) Cp267_0662 ENOG4108RM3 Phosphatase with a broad specificity. Its primary physiological function is to dephosphorylate 3'-phosphoadenosine 5'-phosphate (PAP) and 3'-phosphoadenosine 5'-phosphosulfate (PAPS). Thus, plays a role in mycobacterial sulfur metabolism, since it can serve as a key regulator of the sulfate assimilation pathway by controlling the pools of PAP and PAPS in the cell. To a lesser extent, is also able to hydrolyze inositol 1-phosphate (I- 1-P), fructose 1,6-bisphosphate (FBP) (to fructose 6-phosphate (F- 6-P)) and AMP in vitro, but this might has no significance in vivo Cp267_0664 ENOG4107QRT dEAD DEAH box helicase Cp267_0666 ENOG4108S0J Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized pyrimidines, such as thymine glycol, 5,6-dihydrouracil and 5,6-dihydrothymine. Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'- phosphates (By similarity) Cp267_0672 ENOG41061JJ Peptidase family M23 Cp267_0677 ENOG4105CDA abc transporter atp-binding protein Cp267_0678 ENOG4107UBR Extracellular solute-binding protein family 3 Cp267_0679 ENOG4108Q1T ABC transporter Cp267_0680 ENOG4105DRP amino acid AbC transporter Cp267_0682 ENOG4105EC0 Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity) Cp267_0688 ENOG4105NRA 50s ribosomal protein l31 type b Cp267_0690 ENOG4105ETX regulatoR Cp267_0691 ENOG41062D9 Histidine kinase Cp267_0692 ENOG4105C0H protease Cp267_0693 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) Cp267_0698 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase Cp267_0702 ENOG4108VGI doxx family Cp267_0704 ENOG4105FF9 glycosyl transferase, family 39 Cp267_0706 ENOG4105C94 Transporter Cp267_0707 ENOG4108K88 Membrane Cp267_0710 ENOG4105F8V Hydrolase, tatD family Cp267_0711 ENOG4106839 domain protein Cp267_0714 ENOG4105C5H ABC transporter Cp267_0717 ENOG4105CSR polyphosphate kinase 2 Cp267_0719 ENOG410667J hydrolase Cp267_0728 ENOG4108HGY Proline imino-peptidase Cp267_0729 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) Cp267_0731 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) Cp267_0732 ENOG4105EA8 2-Nitropropane dioxygenase Cp267_0736 ENOG4108IUM Glycogen debranching enzyme Cp267_0737 ENOG4105C5T Phosphoribosyl pyrophosphate synthase Cp267_0738 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) Cp267_0739 ENOG4107TZ2 Cell division protein that is required for growth during stress conditions. May be involved in protecting or stabilizing the divisomal assembly under conditions of stress (By similarity) Cp267_0741 ENOG41082JN Transcriptional regulator Cp267_0744 ENOG4105D5Q Arginine ornithine antiporter Cp267_0745 ENOG4105DXN mazG family Cp267_0757 ENOG4105T1M mycothiol conjugate amidase mca Cp267_0779 ENOG4105C3G gtp-binding protein Cp267_0782 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA Cp267_0783 ENOG4105BZ1 (ABC) transporter Cp267_0785 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) Cp267_0786 ENOG4105CKW Inner membrane protein yedI Cp267_0788 ENOG4105NSK ABC superfamily ATP binding cassette transporter membrane protein Cp267_0789 ENOG4108JJB ABC transporter Cp267_0791 ENOG4105CAT Cytidine monophosphate kinase Cp267_0793 ENOG4108J59 Extracellular solute-binding protein, family 5 Cp267_0794 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component Cp267_0795 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component Cp267_0797 ENOG4108TVX serine protease Cp267_0801 ENOG4105CI3 gtp-binding protein typa Cp267_0805 ENOG4108Z4U Ferredoxin Cp267_0809 ENOG4105C85 amino acid Cp267_0811 ENOG4105C85 amino acid Cp267_0815 ENOG4105EEI dihydropteroate synthase Cp267_0816 ENOG4105C3Q Glycosyl transferase, family 2 Cp267_0821 ENOG4107FQX Alpha-acetolactate decarboxylase Cp267_0822 ENOG4107QPH glycogen) synthase Cp267_0824 ENOG4107ZBN O-methyltransferase Cp267_0830 ENOG4105CJW magnesium transporter Cp267_0832 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 Cp267_0833 ENOG4105BZ1 (ABC) transporter Cp267_0835 ENOG4105F9E Shikimate 5-dehydrogenase Cp267_0836 ENOG4105EBR Carboxylesterase Cp267_0840 ENOG4107WI4 Aldose-1-epimerase Cp267_0844 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) Cp267_0850 ENOG4105CK7 Sodium proline symporter Cp267_0851 ENOG4105C0D helicase Cp267_0856 ENOG4105FS7 Transcriptional regulator Cp267_0859 ENOG4105E98 transcriptional regulator DeoR family Cp267_0861 ENOG41080R8 Conserved Protein Cp267_0862 ENOG4107QR9 Iron-sulfur cluster binding protein Cp267_0863 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) Cp267_0864 ENOG4105DAA L-lactate Cp267_0866 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) Cp267_0867 ENOG4105D6E homoserine dehydrogenase Cp267_0878 ENOG4107UH5 it plays a direct role in the translocation of protons across the membrane (By similarity) Cp267_0879 ENOG4105ZA1 atp synthase Cp267_0880 ENOG4107Z0K Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) (By similarity) Cp267_0894 ENOG4105DKW ABC transporter Cp267_0898 ENOG4105C10 Electron transfer flavoprotein Cp267_0912 ENOG4105EHG Permease protein Cp267_0913 ENOG4105E0A ABC, transporter Cp267_0915 ENOG4105CTQ phosphohexokinase Cp267_0917 ENOG4105CPC Aldo Keto reductase Cp267_0919 ENOG4105CXD Specific inhibitor of chromosomal initiation of replication in vitro. Binds the three 13-mers in the origin (oriC) to block initiation of replication (By similarity) Cp267_0933 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) Cp267_0937 ENOG4105ERH Fumarylacetoacetate hydrolase Cp267_0955 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) Cp267_0956 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) Cp267_0957 ENOG4105DP4 dak2 domain fusion protein ylov Cp267_0959 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit Cp267_0960 ENOG4106H78 methyltransferase Cp267_0964 ENOG4108JEH abc transporter atp-binding protein Cp267_0965 ENOG4105E5Q amino acid AbC transporter Cp267_0971 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) Cp267_0974 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) Cp267_0978 ENOG4105EEM helicase Cp267_0981 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) Cp267_0984 ENOG41084BS 50S ribosomal protein L35 Cp267_0990 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase Cp267_0993 ENOG4105C8Y Acetylornithine aminotransferase Cp267_0997 ENOG4105CH7 arginosuccinase Cp267_0998 ENOG4105W49 UPF0434 protein Cp267_1002 ENOG4105DSU hydrolase Cp267_1010 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) Cp267_1012 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) Cp267_1015 ENOG4105DUX Transporter Cp267_1016 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) Cp267_1018 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) Cp267_1021 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) Cp267_1022 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter Cp267_1024 ENOG4108SEA Esterase Cp267_1025 ENOG4105FF5 Membrane Cp267_1026 ENOG4108HUF Transporter Cp267_1027 ENOG4105DQ5 transport system permease protein Cp267_1028 ENOG4108U1V ABC transporter, permease Cp267_1029 ENOG4105E0A ABC, transporter Cp267_1030 ENOG4105DUU IucA IucC family protein Cp267_1034 ENOG410836F Transposase Cp267_1040 ENOG4105K5B UPF0225 protein Cp267_1043 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving Cp267_1051 ENOG4105C37 (CBS) domain Cp267_1052 ENOG4105C1J atp-dependent rna helicase Cp267_1053 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) Cp267_1055 ENOG4105D7N magnesium and cobalt transport protein CorA Cp267_1059 ENOG4105CSH Transporter Cp267_1064 ENOG4106N3V dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83) Cp267_1067 ENOG4105CTK cobaltochelatase, cobn subunit Cp267_1074 ENOG4108RG3 short-chain dehydrogenase reductase Cp267_1077 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) Cp267_1079 ENOG4107TMB Transcriptional regulator Cp267_1083 ENOG4105E5F proteasome Cp267_1086 ENOG4105DFM M18 family aminopeptidase Cp267_1091 ENOG4108IJ0 Aspartate ammonia-lyase Cp267_1093 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter Cp267_1098 ENOG4105C3R Methionine synthase Cp267_1102 ENOG4107SET aldo keto reductase Cp267_1104 ENOG4107QYT Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) Cp267_1109 ENOG4108UTZ Dihydroxyacetone kinase Cp267_1110 ENOG4105CMT Dihydroxyacetone kinase Cp267_1112 ENOG4105C5H ABC transporter Cp267_1125 ENOG4105ZXU NLP P60 protein Cp267_1131 ENOG4105CAG UPF0210 protein Cp267_1137 ENOG4105VG1 fes assembly suf system protein Cp267_1138 ENOG4108UNV SUF system FeS assembly protein, NifU family Cp267_1140 ENOG4105C3K feS assembly ATPase SufC Cp267_1144 ENOG4107JC6 Membrane Cp267_1149 ENOG4105CV1 Transketolase (EC 2.2.1.1) Cp267_1150 ENOG4107QQX Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) Cp267_1158 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase Cp267_1160 ENOG4105CHW UPF0052 protein Cp267_1162 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) Cp267_1168 ENOG4105DJV ribulose-phosphate 3-epimerase Cp267_1171 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) Cp267_1180 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain Cp267_1182 ENOG4105CD3 dihydroorotase Cp267_1190 ENOG4105DC7 peptidase M24 Cp267_1194 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase Cp267_1198 ENOG41080G3 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) Cp267_1209 ENOG4108UZX fmn reductase Cp267_1210 ENOG4105EJQ L-serine dehydratase Cp267_1216 ENOG4105C5X domain protein Cp267_1217 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) Cp267_1221 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) Cp267_1224 ENOG4107RTU Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) Cp267_1232 ENOG4105C29 acyl-CoA thioesterase Cp267_1235 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) Cp267_1238 ENOG4107YQ3 lipid a biosynthesis lauroyl acyltransferase Cp267_1242 ENOG4105DBE peroxidase Cp267_1249 ENOG4105E0X reductase Cp267_1250 ENOG4107JTW chlorite dismutase Cp267_1268 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) Cp267_1276 ENOG4105JNJ Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) Cp267_1277 ENOG4105D3R alkyl hydroperoxide reductase Cp267_1279 ENOG4105C5Q Transcriptional regulator Cp267_1281 ENOG4105CQ7 ATP-dependent helicase Cp267_1286 ENOG4105E98 transcriptional regulator DeoR family Cp267_1287 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) Cp267_1288 ENOG4105E98 transcriptional regulator DeoR family Cp267_1289 ENOG4105DE4 1-phosphofructokinase Cp267_1290 ENOG4105DM4 PTS System Cp267_1292 ENOG4105KRI phosphocarrier protein (HPr Cp267_1293 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone Cp267_1295 ENOG4105C2W permease Cp267_1296 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) Cp267_1299 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) Cp267_1302 ENOG4105C99 atpase involved in dna repair Cp267_1309 ENOG4107ZYJ bioY protein Cp267_1310 ENOG4108JJB ABC transporter Cp267_1311 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) Cp267_1313 ENOG4105WBV Transcriptional regulator Cp267_1320 ENOG4105CN5 Metallo-Beta-Lactamase Cp267_1328 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) Cp267_1331 ENOG4107QMU Mate efflux family protein Cp267_1340 ENOG4107XFJ UPF0246 protein Cp267_1341 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) Cp267_1342 ENOG4105CNG UPF0061 protein Cp267_1343 ENOG4105CKI cobalamin synthesis protein Cp267_1344 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) Cp267_1346 ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase Cp267_1357 ENOG4105DZP Membrane-associated zinc metalloprotease Cp267_1360 ENOG41068X0 Protein of unknown function (DUF2631) Cp267_1369 ENOG4108IYT Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) Cp267_1371 ENOG4105C0P Mg chelatase subunit ChlI Cp267_1377 ENOG4105DM4 PTS System Cp267_1379 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) Cp267_1380 ENOG4107XUM An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) Cp267_1384 ENOG4105E1P Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity) Cp267_1391 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) Cp267_1396 ENOG4105DCF alanine dehydrogenase Cp267_1397 ENOG4107R37 Glutamate dehydrogenase Cp267_1398 ENOG4105BZW Glycerate kinase Cp267_1401 ENOG4105CH2 amidohydrolase Cp267_1404 ENOG4105CA9 Pyruvate kinase Cp267_1406 ENOG4105DK0 Indole-3-glycerol phosphate synthase Cp267_1410 ENOG4108MWI inositol mono-phosphatase Cp267_1423 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) Cp267_1429 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein Cp267_1430 ENOG4105C7B Threonine dehydratase Cp267_1438 ENOG4105HDK L-asparaginase Cp267_1442 ENOG4107VQS DivIVA family Cp267_1444 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) Cp267_1446 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase Cp267_1447 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) Cp267_1449 ENOG4105DFU Cell wall formation (By similarity) Cp267_1456 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) Cp267_1457 ENOG4105CJN penicillin-binding protein Cp267_1467 ENOG41072RD Membrane Cp267_1468 ENOG4105KYH transcriptional regulatory protein Cp267_1470 ENOG4105C7V phospho-2-dehydro-3-deoxyheptonate aldolase Cp267_1474 ENOG4105DKQ ROK family Cp267_1475 ENOG4105JNK Glycosyl transferase (Group 1 Cp267_1477 ENOG4105K4H Nlp p60 protein Cp267_1489 ENOG4108YZT Adenosylcobinamide kinase Cp267_1490 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) Cp267_1492 ENOG4105CM2 brancheD-chain amino acid aminotransferase Cp267_1496 ENOG4105CBI The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor Cp267_1497 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) Cp267_1517 ENOG4107QMH DNA methylase Cp267_1537 ENOG4105D3Y Na H antiporter Cp267_1538 ENOG4105E09 nadh pyrophosphatase Cp267_1540 ENOG4105D98 threonine synthase Cp267_1545 ENOG4105C5F glutamine synthetase Cp267_1550 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) Cp267_1552 ENOG4105CVJ phosphoglycerate mutase Cp267_1554 ENOG4105EGD dinuclear metal center protein, YbgI family Cp267_1559 ENOG4105DH2 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity) Cp267_1562 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) Cp267_1568 ENOG4105EN6 Membrane Cp267_1580 ENOG4105D9H Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) Cp267_1586 ENOG4106DBE Involved in DNA repair and RecF pathway recombination (By similarity) Cp267_1597 ENOG4108IQE Amp-dependent synthetase and ligase Cp267_1601 ENOG4105DGW oligopeptidase A Cp267_1602 ENOG4105EBR Carboxylesterase Cp267_1607 ENOG4105BZ1 (ABC) transporter Cp267_1608 ENOG4105CWM branched-chain amino acid transport system II carrier protein Cp267_1609 ENOG4105DEN Luciferase family Cp267_1611 ENOG4105C94 Transporter Cp267_1614 ENOG4105DEF Extracellular solute-binding protein, family 5 Cp267_1616 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component Cp267_1617 ENOG4108JQ5 ABC transporter Cp267_1620 ENOG4105DFA alanine racemase domain protein Cp267_1621 ENOG4105CUC YeeE YedE family protein Cp267_1625 ENOG4108EU3 peptide transport system, permease Cp267_1627 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) Cp267_1628 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) Cp267_1633 ENOG4105CCF Lysine exporter protein (Lyse ygga) Cp267_1638 ENOG4107Z8D degv family Cp267_1639 ENOG4105CVJ phosphoglycerate mutase Cp267_1641 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) Cp267_1644 ENOG4105WD1 Membrane Cp267_1645 ENOG4105D0C transport protein Cp267_1650 ENOG4105C03 ribonuclease Cp267_1654 ENOG4105CIF Ornithine Cyclodeaminase Cp267_1656 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase Cp267_1665 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation Cp267_1669 ENOG4105EUB pirin domain protein Cp267_1671 ENOG4105MC2 DSBA oxidoreductase Cp267_1675 ENOG4105D8X mechanosensitive ion channel Cp267_1691 ENOG4108M15 ABC transporter Cp267_1692 ENOG4105E4J Cytochrome c oxidase caa3-type, assembly factor ctag-related protein Cp267_1695 ENOG4105D22 carbon starvation protein Cp267_1697 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin Cp267_1699 ENOG4105D3Z quinone oxidoreductase, yhdh yhfp family Cp267_1700 ENOG4105EMU Dehydrogenase Cp267_1703 ENOG4107UBC ErfK ybiS ycfS ynhG family protein Cp267_1704 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein Cp267_1705 ENOG4108RWI nicotinamidase Cp267_1714 ENOG4105WH1 Two component transcriptional regulator luxr family Cp267_1723 ENOG4108RQ5 Beta-lactamase domain-containing protein Cp267_1728 ENOG4107RKP Nicotinate phosphoribosyltransferase Cp267_1738 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) Cp267_1741 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) Cp267_1742 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) Cp267_1743 ENOG4105WAZ (Glutaredoxin-like protein) NrdH Cp267_1745 ENOG4107RA1 nh(3)-dependent nad( ) synthetase Cp267_1758 ENOG4107QIX Phosphoglucomutase (EC 5.4.2.2 Cp267_1761 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) Cp267_1762 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) Cp267_1769 ENOG4105D7W serine acetyltransferase Cp267_1772 ENOG4105C4M (Ubiquinol oxidase) subunit I Cp267_1773 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii Cp267_1774 ENOG4108JJ9 ABC, transporter Cp267_1775 ENOG4108JJ9 ABC, transporter Cp267_1780 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) Cp267_1786 ENOG4105CBD Diacylglycerol kinase Cp267_1789 ENOG4106XY2 Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity) Cp267_1794 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) Cp267_1795 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) Cp267_1797 ENOG4108JIU phosphoribosylformylglycinamidine synthase ii Cp267_1798 ENOG4105D21 Phosphoribosylformylglycinamidine synthase I Cp267_1799 ENOG410839H phosphoribosylformylglycinamidine synthase Cp267_1800 ENOG4108V06 Glutathione peroxidase Cp267_1804 ENOG4105C83 adenylosuccinate lyase Cp267_1805 ENOG4107ZYR domain protein Cp267_1806 ENOG4105CZN Potassium uptake protein Cp267_1807 ENOG4105C12 Phosphoribosylglycinamide synthetase Cp267_1808 ENOG4107ZUX Histidine triad (HIT) protein Cp267_1810 ENOG4105BZU Histidine kinase Cp267_1811 ENOG4105CK6 Two component transcriptional regulator (Winged helix family Cp267_1812 ENOG4105C57 major facilitator superfamily Cp267_1817 ENOG4105C7K acetolactate synthase Cp267_1827 ENOG4105C2N RNA methyltransferase TrmH family group 3 Cp267_1831 ENOG4108VJ1 Transcriptional regulator (CarD family Cp267_1835 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) Cp267_1837 ENOG4108V9Q carbonic anhydrase Cp267_1841 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit Cp267_1843 ENOG41080V3 Major Facilitator superfamily Cp267_1844 ENOG4105DU0 nucleoside hydrolase Cp267_1847 ENOG4105CRK lysyL-tRNA synthetase Cp267_1851 ENOG4105C26 Dehydrogenase Cp267_1852 ENOG4105C94 Transporter Cp267_1854 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) Cp267_1861 ENOG4105EUJ GTP cyclohydrolase i Cp267_1862 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) Cp267_1863 ENOG4108UGV hypoxanthine phosphoribosyltransferase Cp267_1866 ENOG4105F0N pyrophosphate phospho-hydrolase Cp267_1867 ENOG4105VFE sira family Cp267_1868 ENOG4107QJT sodium dicarboxylate symporter Cp267_1872 ENOG4105CEY Amp-dependent synthetase and ligase Cp267_1874 ENOG4105CSR polyphosphate kinase 2 Cp267_1878 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) Cp267_1883 ENOG4105D65 subunit l Cp267_1884 ENOG4105MKQ Monovalent cation H antiporter subunit C Cp267_1885 ENOG4108JPZ Monovalent cation H antiporter subunit D Cp267_1889 ENOG4108U8T Mannosyltransferase Cp267_1893 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) Cp267_1894 ENOG4105KEG ribosomal-protein-alanine acetyltransferase Cp267_1895 ENOG4105CGK Exodeoxyribonuclease III Cp267_1896 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) Cp267_1901 ENOG4105CT1 (ABC) transporter Cp267_1904 ENOG4108IJ2 phosphate acetyltransferase Cp267_1908 ENOG4108HH9 Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR Cp267_1909 ENOG4105DYA Acts on guanine, xanthine and to a lesser extent hypoxanthine (By similarity) Cp267_1916 ENOG4105CRE cytochrome C Cp267_1917 ENOG4105EBH Required during biogenesis of c-type cytochromes (cytochrome c6 and cytochrome f) at the step of heme attachment (By similarity) Cp267_1919 ENOG4105EAU Plays a role in nitrite reduction (By similarity) Cp267_1920 ENOG4108W6G cytochrome C Cp267_1932 ENOG4107RCW fructose-bisphosphate aldolase Cp267_1935 ENOG41065E1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) Cp267_1938 ENOG4105C6V Glycerol-3-phosphate dehydrogenase Cp267_1948 ENOG4105CJ1 ABC, transporter Cp267_1957 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) Cp267_1958 ENOG4105C19 ABC transporter Cp267_1959 ENOG4105DJY efflux transporter, rnd family, mfp subunit Cp267_1964 ENOG4105C26 Dehydrogenase Cp267_1967 ENOG4105KNI merR family transcriptional Regulator Cp267_1970 ENOG4105CFG Acts as a chaperone (By similarity) Cp267_1983 ENOG4105DF6 Fe-S oxidoreductase Cp267_1986 ENOG4105E0A ABC, transporter Cp267_1987 ENOG4108ESU Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Involved in the translocation of the substrate across the membrane (By similarity) Cp267_1989 ENOG4105ICD Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) Cp267_1990 ENOG4107S16 Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG (By similarity) Cp267_1991 ENOG4108YH3 Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) Cp267_1992 ENOG4105HFU Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly (By similarity) Cp267_1993 ENOG4105CQM Urea amidohydrolase subunit alpha Cp267_1994 ENOG4105KI2 Urea amidohydrolase subunit beta Cp267_1995 ENOG4108YZ9 Urea amidohydrolase subunit gamma Cp267_2000 ENOG4105CRK lysyL-tRNA synthetase Cp267_2004 ENOG4105C6Y Udp-glucose 6-dehydrogenase Cp267_2006 ENOG4105C26 Dehydrogenase Cp267_2008 ENOG4107QPA Cleaves GlcNAc linked beta-1,4 to MurNAc tripeptides (By similarity) Cp267_2010 ENOG41073B4 coagulation factor 5 8 type domain-containing protein Cp267_2011 ENOG4105EXC Acyl-transferase Cp267_2015 ENOG4108M6P methyltransferase Cp267_2024 ENOG4105D8K carboxyl transferase Cp267_2025 ENOG4107EEY synthase Cp267_2026 ENOG4107RCI amp-dependent synthetase and ligase Cp267_2029 ENOG4107YB1 Trehalose corynomycolyl transferase Cp267_2032 ENOG4107ISF Involved in the biosynthesis of the arabinogalactan (AG) region of the mycolylarabinogalactan-peptidoglycan (mAGP) complex, an essential component the mycobacterial cell wall. Catalyzes the transfer of arabinofuranosyl (Araf) residues residue from the sugar donor beta-D-arabinofuranosyl-1-monophosphoryldecaprenol (DPA) to the arabinan domain to form terminal beta-(1- 2)-linked Araf residues, which marks the end point for AG arabinan biosynthesis before decoration with mycolic acids Cp267_2033 ENOG4106YN8 Prenyltransferase Cp267_2035 ENOG410602S Transferase Cp267_2037 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase Cp267_2039 ENOG4108QXE glycerophosphoryl diester phosphodiesterase Cp267_2043 ENOG4105EHG Permease protein Cp267_2044 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) Cp267_2047 ENOG4108KP7 hydrolase Cp267_2050 ENOG4105FDP GntR family transcriptional regulator Cp267_2054 ENOG4105CQC Prephenate dehydratase Cp267_2055 ENOG4105DV0 amidase (EC 3.5.1.4 Cp267_2057 ENOG4108KGH TRANSCRIPTIONal Cp267_2063 ENOG4105D9N nucleoside Cp267_2069 ENOG4108YYH Nadph-dependent fmn reductase Cp267_2070 ENOG4105D94 Major Facilitator Superfamily Cp267_2073 ENOG4105CXY transporter Cp267_2075 ENOG4108VJY integral membrane protein Cp267_2079 ENOG4105WH1 Two component transcriptional regulator luxr family Cp267_2083 ENOG4108RN7 integral membrane protein Cp267_2084 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins Cp267_2093 ENOG4105DVE abc transporter atp-binding protein Cp267_2097 ENOG41080RH Thioredoxin Cp267_2100 ENOG41079KZ Major Facilitator Superfamily Cp267_2102 ENOG4105BZP glycoside hydrolase 15-related Cp267_2106 ENOG4107YH6 single-stranded DNA-binding protein Cp267_2112 ENOG4105BZ4 penicillin-binding protein Cp267_2116 ENOG4108RKS Short-chain dehydrogenase reductase Sdr Cp267_2119 ENOG4107XFB conserved TRANSMEMBRANE PROTEIN Cp267_2120 ENOG4105DPV During stationary phase, binds the chromosome non- specifically, forming a highly ordered and stable dps-DNA co- crystal within which chromosomal DNA is condensed and protected from diverse damages. It protects DNA from oxidative damage by sequestering intracellular Fe(2 ) ion and storing it in the form of Fe(3 ) oxyhydroxide mineral, which can be released after reduction. One hydrogen peroxide oxidizes two Fe(2 ) ions, which prevents hydroxyl radical production by the Fenton reaction Cp267_2121 ENOG4108S0J Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized pyrimidines, such as thymine glycol, 5,6-dihydrouracil and 5,6-dihydrothymine. Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'- phosphates (By similarity) Cp267_2124 ENOG4105ECB domain protein Cp267_2129 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) Cp267_2133 ENOG4105ENE Histidine kinase Cp267_2134 ENOG4105WH1 Two component transcriptional regulator luxr family Cp267_2137 ENOG4105CE4 GlcNAc 6-P deacetylase Cp267_2140 ENOG4107EJG GntR family transcriptional regulator Cp267_2141 ENOG4105DEF Extracellular solute-binding protein, family 5 Cp267_2142 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component Cp267_2144 ENOG4108JQ7 (ABC) transporter Cp267_2145 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) Cp267_2153 ENOG4106178 UPF0339 protein Cp267_2156 ENOG4107QV7 Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system) (By similarity) Cp267_2158 ENOG4105EWK phytoene Cp267_2160 ENOG4105CRQ synthase (Component I) Cp267_2161 ENOG4105RGK anthranilate synthase component ii Cp267_2163 ENOG4105DK0 Indole-3-glycerol phosphate synthase Cp267_2167 ENOG4105DHU Bile acid Cp267_2169 ENOG4105KMT branched-chain amino acid Cp267_2171 ENOG4108UJU UPF0301 protein Cp267_2172 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate Cp267_2177 ENOG4105EMN RNA polymerase sigma factor Cp267_2178 ENOG4105C3M thioredoxin reductase Cp267_2179 ENOG4105K63 Thioredoxin Cp267_2180 ENOG4108E1C hydrolase Cp267_2183 ENOG4107QJE Chromosome Partitioning Protein Cp267_2188 ENOG41084CH 50S ribosomal protein l34