locus-tag class description CpCap1W_0002 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) CpCap1W_0005 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) CpCap1W_0009 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) CpCap1W_0018 ENOG4107SDZ Galactoside transport system permease protein mglC CpCap1W_0019 ENOG4105C2J ABC transporter CpCap1W_0032 ENOG4105E0A ABC, transporter CpCap1W_0033 ENOG4105TVJ transport system, permease CpCap1W_0034 ENOG4105DQ5 transport system permease protein CpCap1W_0035 ENOG4108MES Periplasmic binding protein CpCap1W_0036 ENOG4105XBB septation inhibitor protein CpCap1W_0037 ENOG4108DT4 serine threonine protein kinase CpCap1W_0039 ENOG4105CJN penicillin-binding protein CpCap1W_0043 ENOG4105TV9 FHA Domain-Containing protein CpCap1W_0043 ENOG4105TV9 FHA Domain-Containing protein CpCap1W_0049 ENOG4105E0A ABC, transporter CpCap1W_0050 ENOG4105EHG Permease protein CpCap1W_0051 ENOG4105CJW magnesium transporter CpCap1W_0053 ENOG4105CG3 alpha amylase, catalytic region CpCap1W_0058 ENOG4105K6V RNA polymerase CpCap1W_0065 ENOG4108IJ8 ABC transporter CpCap1W_0067 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) CpCap1W_0069 ENOG41066NP positive regulation by symbiont of host immune response CpCap1W_0071 ENOG4105FYV Amp nucleosidase CpCap1W_0073 ENOG4107YXZ hydrolase, family 25 CpCap1W_0078 ENOG4108Z0R Transferase CpCap1W_0081 ENOG4108URH decarboxylase CpCap1W_0083 ENOG4105K56 Transcriptional regulator CpCap1W_0086 ENOG4108KK1 membrane protein AbrB duplication CpCap1W_0088 ENOG4105EJ9 Membrane CpCap1W_0089 ENOG4106ETB IIa component CpCap1W_0091 ENOG4105CQ7 ATP-dependent helicase CpCap1W_0093 ENOG4105CF1 Alkylated DNA repair protein CpCap1W_0094 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) CpCap1W_0096 ENOG4105K8R UPF0145 protein CpCap1W_0097 ENOG410848D S4 domain protein YaaA CpCap1W_0102 ENOG4108JQ0 Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) CpCap1W_0103 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) CpCap1W_0105 ENOG4105C9K Endothelin-converting enzyme 1 CpCap1W_0109 ENOG4105J1Z Arabinosyltransferase CpCap1W_0110 ENOG4108K7T Involved in the biosynthesis of the arabinogalactan (AG) region of the mycolylarabinogalactan-peptidoglycan (mAGP) complex, an essential component the mycobacterial cell wall. Catalyzes the addition of the first key arabinofuranosyl (Araf) residue from the sugar donor beta-D-arabinofuranosyl-1-monophosphoryldecaprenol (DPA) on the C-5 of a 6-linked galactofuranosyl (Galf) of the galactan domain, thus 'priming' the galactan for further elaboration by other arabinofuranosyltransferases CpCap1W_0111 ENOG4108RG3 short-chain dehydrogenase reductase CpCap1W_0112 ENOG4105IQ5 FAD linked oxidase domain protein CpCap1W_0118 ENOG4108MKI Glycosyl transferase, family 2 CpCap1W_0120 ENOG4107SIG periplasmic solute binding protein CpCap1W_0121 ENOG4105DIK (ABC) transporter CpCap1W_0122 ENOG4107RPQ ABC transporter CpCap1W_0123 ENOG4107RBD ABC, transporter CpCap1W_0124 ENOG4105DSE periplasmic solute binding protein CpCap1W_0129 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein CpCap1W_0134 ENOG4105C8P )-transporter CpCap1W_0138 ENOG4105DSQ Nitric oxide reductase CpCap1W_0141 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family CpCap1W_0144 ENOG4105EVN Prephenate dehydrogenase CpCap1W_0146 ENOG4108Z6B deaminase CpCap1W_0148 ENOG4105EYF MMPL domain protein CpCap1W_0149 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) CpCap1W_0151 ENOG4105C6Z Gluconate CpCap1W_0152 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family CpCap1W_0153 ENOG4105CPQ Dehydrogenase CpCap1W_0154 ENOG4105CHR reductase CpCap1W_0157 ENOG4105XT2 Transcriptional regulator CpCap1W_0162 ENOG4105C6Z Gluconate CpCap1W_0163 ENOG4105ZXK Dehydrogenase CpCap1W_0166 ENOG4105ERH Fumarylacetoacetate hydrolase CpCap1W_0169 ENOG4105F1K Glutamine amidotransferase CpCap1W_0170 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) CpCap1W_0174 ENOG4107RHR regulatoR CpCap1W_0175 ENOG4105D3A purine nucleoside phosphorylase DeoD-type CpCap1W_0178 ENOG4107QSU Phosphoglucomutase phosphomannomutase alpha beta alpha domain CpCap1W_0181 ENOG4105DUY Ser-Asp rich fibrinogen-binding, bone sialoprotein-binding protein CpCap1W_0184 ENOG4105PP6 Membrane CpCap1W_0185 ENOG4105CFH Aspartokinase CpCap1W_0186 ENOG4105DUY Ser-Asp rich fibrinogen-binding, bone sialoprotein-binding protein CpCap1W_0189 ENOG4105CH6 catalase CpCap1W_0197 ENOG4107QKW extracellular solute-binding protein family 1 CpCap1W_0198 ENOG4105CXY transporter CpCap1W_0199 ENOG4105CK6 Two component transcriptional regulator (Winged helix family CpCap1W_0200 ENOG4105BZU Histidine kinase CpCap1W_0204 ENOG4108JPZ Monovalent cation H antiporter subunit D CpCap1W_0206 ENOG4105D65 subunit l CpCap1W_0208 ENOG4108NJC CpCap1W_0210 ENOG4108IUX (ABC) transporter CpCap1W_0217 ENOG4105BZ4 penicillin-binding protein CpCap1W_0218 ENOG4105N0U Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) CpCap1W_0222 ENOG4105IJJ transcriptional regulator, crp fnr family CpCap1W_0226 ENOG4105P8F nudix hydrolase CpCap1W_0240 ENOG4108I5C dEAD DEAH box helicase CpCap1W_0242 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) CpCap1W_0243 ENOG4105EPD Oligopeptide transporter, Opt family CpCap1W_0245 ENOG4107QRG dna polymerase iii CpCap1W_0249 ENOG4105CEY Amp-dependent synthetase and ligase CpCap1W_0251 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) CpCap1W_0253 ENOG4105C1B dTDP-glucose 4-6-dehydratase CpCap1W_0259 ENOG4107QN2 dihydrolipoyl dehydrogenase CpCap1W_0260 ENOG4105CFF transcriptional regulator CpCap1W_0263 ENOG4105E33 succinate dehydrogenase CpCap1W_0265 ENOG4106BRA Membrane CpCap1W_0267 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) CpCap1W_0271 ENOG4105C6N Formate acetyltransferase CpCap1W_0275 ENOG4105CEY Amp-dependent synthetase and ligase CpCap1W_0278 ENOG4105BZU Histidine kinase CpCap1W_0279 ENOG4105CK6 Two component transcriptional regulator (Winged helix family CpCap1W_0283 ENOG4105II7 pyrroline-5-carboxylate reductase CpCap1W_0286 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) CpCap1W_0288 ENOG4108RXW HAD-superfamily subfamily IB hydrolase CpCap1W_0292 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) CpCap1W_0295 ENOG4105C59 p-type ATPase CpCap1W_0297 ENOG4105C1Q protoporphyrinogen oxidase CpCap1W_0300 ENOG4108RH7 phosphoglycerate mutase CpCap1W_0304 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) CpCap1W_0307 ENOG4105EHG Permease protein CpCap1W_0308 ENOG4105CRE cytochrome C CpCap1W_0314 ENOG4105CEE C4-dicarboxylate transporter CpCap1W_0315 ENOG4107TCW O-succinylbenzoate synthase CpCap1W_0318 ENOG4105BZF Glycosyl transferase (Group 1 CpCap1W_0320 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) CpCap1W_0321 ENOG4105P52 geranylgeranyl reductase CpCap1W_0327 ENOG410683Z Preprotein translocase SecE subunit CpCap1W_0332 ENOG4105CTZ aminopeptidase c CpCap1W_0333 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase CpCap1W_0337 ENOG4105DSE periplasmic solute binding protein CpCap1W_0339 ENOG4105DIK (ABC) transporter CpCap1W_0340 ENOG4105CC5 ABC transporter CpCap1W_0345 ENOG4105BZU Histidine kinase CpCap1W_0346 ENOG4105WH1 Two component transcriptional regulator luxr family CpCap1W_0348 ENOG4105CJ1 ABC, transporter CpCap1W_0351 ENOG4108PJD permease CpCap1W_0366 ENOG4105VBF alkaline shock protein CpCap1W_0367 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) CpCap1W_0388 ENOG4105C44 Serine transporter CpCap1W_0389 ENOG4105EJQ L-serine dehydratase CpCap1W_0391 ENOG4105HDK L-asparaginase CpCap1W_0402 ENOG4105EG2 ABC transporter, permease CpCap1W_0406 ENOG4108IJ9 (ABC) transporter CpCap1W_0408 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) CpCap1W_0418 ENOG4108ZT0 50S ribosomal protein l17 CpCap1W_0424 ENOG4105EC2 ftsk spoIIIe CpCap1W_0436 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) CpCap1W_0449 ENOG4107QVP Dehydrogenase CpCap1W_0458 ENOG4108UMI ABC transporter, permease CpCap1W_0460 ENOG4105D01 (LipO)protein CpCap1W_0462 ENOG4105D01 (LipO)protein CpCap1W_0467 ENOG4105DSE periplasmic solute binding protein CpCap1W_0468 ENOG4105DIK (ABC) transporter CpCap1W_0469 ENOG4107RBD ABC, transporter CpCap1W_0470 ENOG4107RPQ ABC transporter CpCap1W_0471 ENOG4107R5H iron (metal) dependent repressor, dtxr family CpCap1W_0472 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) CpCap1W_0473 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) CpCap1W_0480 ENOG4105DQ5 transport system permease protein CpCap1W_0481 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) CpCap1W_0484 ENOG4105E9K Isocitrate dehydrogenase CpCap1W_0485 ENOG4105F27 Major Facilitator CpCap1W_0486 ENOG4108Z5V transcriptional regulator, merr family CpCap1W_0489 ENOG4105C31 Tryptophanyl-tRNA synthetase CpCap1W_0490 ENOG4107H3J ribonuclease CpCap1W_0491 ENOG4105DZ1 carboxypeptidase CpCap1W_0497 ENOG4107QSU Phosphoglucomutase phosphomannomutase alpha beta alpha domain CpCap1W_0498 ENOG4107RM1 amidohydrolase CpCap1W_0500 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) CpCap1W_0503 ENOG4108JIK carboxylase CpCap1W_0504 ENOG4105KHC sulfurtransferase CpCap1W_0507 ENOG4105EXC Acyl-transferase CpCap1W_0509 ENOG4107WR6 Maf-like protein CpCap1W_0510 ENOG4108RVA ribokinase CpCap1W_0511 ENOG4105ETE Transcriptional regulator (LacI family CpCap1W_0513 ENOG4105D8K carboxyl transferase CpCap1W_0514 ENOG4105D8K carboxyl transferase CpCap1W_0516 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase CpCap1W_0527 ENOG4107TB5 TRANSCRIPTIONal CpCap1W_0531 ENOG4105K51 Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) CpCap1W_0536 ENOG4105EIP mannose-6-phosphate isomerase CpCap1W_0543 ENOG4105CK6 Two component transcriptional regulator (Winged helix family CpCap1W_0544 ENOG4105BZU Histidine kinase CpCap1W_0547 ENOG4108S7Q sigma 54 modulation protein ribosomal protein S30ea CpCap1W_0555 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase CpCap1W_0556 ENOG4108RAV Conserved protein CpCap1W_0557 ENOG4108Z66 YbaK ebsC protein CpCap1W_0564 ENOG4105C1J atp-dependent rna helicase CpCap1W_0569 ENOG4105C4R Atp-dependent dna helicase CpCap1W_0571 ENOG4105E09 nadh pyrophosphatase CpCap1W_0576 ENOG41063PX domain protein CpCap1W_0596 ENOG4105C85 amino acid CpCap1W_0597 ENOG4107QSA Oxaloacetate decarboxylase CpCap1W_0598 ENOG4107QX3 carboxylase CpCap1W_0600 ENOG4107QSA Oxaloacetate decarboxylase CpCap1W_0602 ENOG4107TK4 histidinol-phosphate phosphatase CpCap1W_0603 ENOG4107TK4 histidinol-phosphate phosphatase CpCap1W_0606 ENOG4105CFC Transporter CpCap1W_0607 ENOG4105CAK Cell division ATP-binding protein ftsE CpCap1W_0608 ENOG4107RYD Part of the ABC transporter FtsEX involved in cellular division (By similarity) CpCap1W_0610 ENOG4107B2H carbonic anhydrase CpCap1W_0613 ENOG4105CM4 permease protein CpCap1W_0614 ENOG4108IPW abc transporter atp-binding protein CpCap1W_0624 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins CpCap1W_0625 ENOG4108RN7 integral membrane protein CpCap1W_0629 ENOG4105WH1 Two component transcriptional regulator luxr family CpCap1W_0634 ENOG4108VJY integral membrane protein CpCap1W_0636 ENOG4105CXY transporter CpCap1W_0640 ENOG4105D94 Major Facilitator Superfamily CpCap1W_0641 ENOG4108YYH Nadph-dependent fmn reductase CpCap1W_0649 ENOG4105D9N nucleoside CpCap1W_0655 ENOG4108KGH TRANSCRIPTIONal CpCap1W_0657 ENOG4105DV0 amidase (EC 3.5.1.4 CpCap1W_0662 ENOG4105FDP GntR family transcriptional regulator CpCap1W_0665 ENOG4108KP7 hydrolase CpCap1W_0669 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) CpCap1W_0670 ENOG4105EHG Permease protein CpCap1W_0673 ENOG4105CXY transporter CpCap1W_0674 ENOG4108QXE glycerophosphoryl diester phosphodiesterase CpCap1W_0676 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase CpCap1W_0678 ENOG410602S Transferase CpCap1W_0680 ENOG4106YN8 Prenyltransferase CpCap1W_0682 ENOG4107ISF Involved in the biosynthesis of the arabinogalactan (AG) region of the mycolylarabinogalactan-peptidoglycan (mAGP) complex, an essential component the mycobacterial cell wall. Catalyzes the transfer of arabinofuranosyl (Araf) residues residue from the sugar donor beta-D-arabinofuranosyl-1-monophosphoryldecaprenol (DPA) to the arabinan domain to form terminal beta-(1- 2)-linked Araf residues, which marks the end point for AG arabinan biosynthesis before decoration with mycolic acids CpCap1W_0685 ENOG4107YB1 Trehalose corynomycolyl transferase CpCap1W_0688 ENOG4107RCI amp-dependent synthetase and ligase CpCap1W_0689 ENOG4107EEY synthase CpCap1W_0690 ENOG4105D8K carboxyl transferase CpCap1W_0699 ENOG4108M6P methyltransferase CpCap1W_0700 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) CpCap1W_0703 ENOG4105EXC Acyl-transferase CpCap1W_0704 ENOG41073B4 coagulation factor 5 8 type domain-containing protein CpCap1W_0706 ENOG4107QPA Cleaves GlcNAc linked beta-1,4 to MurNAc tripeptides (By similarity) CpCap1W_0708 ENOG4105C26 Dehydrogenase CpCap1W_0711 ENOG4105C6Y Udp-glucose 6-dehydrogenase CpCap1W_0715 ENOG4105CRK lysyL-tRNA synthetase CpCap1W_0720 ENOG4108YZ9 Urea amidohydrolase subunit gamma CpCap1W_0721 ENOG4105KI2 Urea amidohydrolase subunit beta CpCap1W_0722 ENOG4105CQM Urea amidohydrolase subunit alpha CpCap1W_0723 ENOG4105HFU Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly (By similarity) CpCap1W_0724 ENOG4108YH3 Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) CpCap1W_0725 ENOG4107S16 Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG (By similarity) CpCap1W_0726 ENOG4105ICD Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) CpCap1W_0728 ENOG4108ESU Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Involved in the translocation of the substrate across the membrane (By similarity) CpCap1W_0729 ENOG4105E0A ABC, transporter CpCap1W_0732 ENOG4105DF6 Fe-S oxidoreductase CpCap1W_0744 ENOG4105CFG Acts as a chaperone (By similarity) CpCap1W_0747 ENOG4105KNI merR family transcriptional Regulator CpCap1W_0750 ENOG4105C26 Dehydrogenase CpCap1W_0751 ENOG4105C26 Dehydrogenase CpCap1W_0756 ENOG4105DJY efflux transporter, rnd family, mfp subunit CpCap1W_0757 ENOG4105C19 ABC transporter CpCap1W_0758 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) CpCap1W_0761 ENOG4105DWV Homoserine O-trans-acetylase CpCap1W_0767 ENOG4105CJ1 ABC, transporter CpCap1W_0776 ENOG4105C6V Glycerol-3-phosphate dehydrogenase CpCap1W_0780 ENOG41065E1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) CpCap1W_0784 ENOG4107RCW fructose-bisphosphate aldolase CpCap1W_0796 ENOG4108W6G cytochrome C CpCap1W_0797 ENOG4105EAU Plays a role in nitrite reduction (By similarity) CpCap1W_0799 ENOG4105EBH Required during biogenesis of c-type cytochromes (cytochrome c6 and cytochrome f) at the step of heme attachment (By similarity) CpCap1W_0800 ENOG4105CRE cytochrome C CpCap1W_0807 ENOG4105DYA Acts on guanine, xanthine and to a lesser extent hypoxanthine (By similarity) CpCap1W_0808 ENOG4108HH9 Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR CpCap1W_0812 ENOG4108IJ2 phosphate acetyltransferase CpCap1W_0815 ENOG4105CT1 (ABC) transporter CpCap1W_0820 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) CpCap1W_0821 ENOG4105CGK Exodeoxyribonuclease III CpCap1W_0822 ENOG4105KEG ribosomal-protein-alanine acetyltransferase CpCap1W_0823 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) CpCap1W_0827 ENOG4108U8T Mannosyltransferase CpCap1W_0831 ENOG4108JPZ Monovalent cation H antiporter subunit D CpCap1W_0832 ENOG4105MKQ Monovalent cation H antiporter subunit C CpCap1W_0833 ENOG4105D65 subunit l CpCap1W_0839 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) CpCap1W_0843 ENOG4105CSR polyphosphate kinase 2 CpCap1W_0845 ENOG4105CEY Amp-dependent synthetase and ligase CpCap1W_0848 ENOG4107QJT sodium dicarboxylate symporter CpCap1W_0849 ENOG4105VFE sira family CpCap1W_0850 ENOG4105F0N pyrophosphate phospho-hydrolase CpCap1W_0853 ENOG4108UGV hypoxanthine phosphoribosyltransferase CpCap1W_0854 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) CpCap1W_0855 ENOG4105EUJ GTP cyclohydrolase i CpCap1W_0856 ENOG4105EEI dihydropteroate synthase CpCap1W_0862 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) CpCap1W_0864 ENOG4105C94 Transporter CpCap1W_0865 ENOG4105C26 Dehydrogenase CpCap1W_0869 ENOG4105CRK lysyL-tRNA synthetase CpCap1W_0872 ENOG4105DU0 nucleoside hydrolase CpCap1W_0873 ENOG41080V3 Major Facilitator superfamily CpCap1W_0875 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit CpCap1W_0879 ENOG4108V9Q carbonic anhydrase CpCap1W_0881 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) CpCap1W_0885 ENOG4108VJ1 Transcriptional regulator (CarD family CpCap1W_0889 ENOG4105C2N RNA methyltransferase TrmH family group 3 CpCap1W_0899 ENOG4105C7K acetolactate synthase CpCap1W_0905 ENOG4105CK6 Two component transcriptional regulator (Winged helix family CpCap1W_0906 ENOG4105BZU Histidine kinase CpCap1W_0908 ENOG4107ZUX Histidine triad (HIT) protein CpCap1W_0909 ENOG4105C12 Phosphoribosylglycinamide synthetase CpCap1W_0910 ENOG4105CZN Potassium uptake protein CpCap1W_0911 ENOG4107ZYR domain protein CpCap1W_0912 ENOG4105C83 adenylosuccinate lyase CpCap1W_0916 ENOG4108V06 Glutathione peroxidase CpCap1W_0917 ENOG410839H phosphoribosylformylglycinamidine synthase CpCap1W_0918 ENOG4105D21 Phosphoribosylformylglycinamidine synthase I CpCap1W_0919 ENOG4108JIU phosphoribosylformylglycinamidine synthase ii CpCap1W_0921 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) CpCap1W_0922 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) CpCap1W_0927 ENOG4106XY2 Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity) CpCap1W_0930 ENOG4105CBD Diacylglycerol kinase CpCap1W_0936 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) CpCap1W_0941 ENOG4108JJ9 ABC, transporter CpCap1W_0942 ENOG4108JJ9 ABC, transporter CpCap1W_0943 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii CpCap1W_0944 ENOG4105C4M (Ubiquinol oxidase) subunit I CpCap1W_0953 ENOG4105D7W serine acetyltransferase CpCap1W_0963 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) CpCap1W_0964 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) CpCap1W_0967 ENOG4107QIX Phosphoglucomutase (EC 5.4.2.2 CpCap1W_0982 ENOG4107RA1 nh(3)-dependent nad( ) synthetase CpCap1W_0984 ENOG4105WAZ (Glutaredoxin-like protein) NrdH CpCap1W_0985 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) CpCap1W_0986 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) CpCap1W_0988 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) CpCap1W_0998 ENOG4107RKP Nicotinate phosphoribosyltransferase CpCap1W_1003 ENOG4108RQ5 Beta-lactamase domain-containing protein CpCap1W_1013 ENOG4105WH1 Two component transcriptional regulator luxr family CpCap1W_1022 ENOG4108RWI nicotinamidase CpCap1W_1023 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein CpCap1W_1025 ENOG4107UBC ErfK ybiS ycfS ynhG family protein CpCap1W_1029 ENOG4105EMU Dehydrogenase CpCap1W_1030 ENOG4105D3Z quinone oxidoreductase, yhdh yhfp family CpCap1W_1032 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin CpCap1W_1035 ENOG4105D22 carbon starvation protein CpCap1W_1036 ENOG4105E4J Cytochrome c oxidase caa3-type, assembly factor ctag-related protein CpCap1W_1037 ENOG4108M15 ABC transporter CpCap1W_1054 ENOG4105D8X mechanosensitive ion channel CpCap1W_1056 ENOG4105MC2 DSBA oxidoreductase CpCap1W_1058 ENOG4105EUB pirin domain protein CpCap1W_1063 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation CpCap1W_1071 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase CpCap1W_1073 ENOG4105CIF Ornithine Cyclodeaminase CpCap1W_1077 ENOG4105C03 ribonuclease CpCap1W_1082 ENOG4105D0C transport protein CpCap1W_1083 ENOG4105WD1 Membrane CpCap1W_1086 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) CpCap1W_1088 ENOG4105CVJ phosphoglycerate mutase CpCap1W_1089 ENOG4107Z8D degv family CpCap1W_1094 ENOG4105CCF Lysine exporter protein (Lyse ygga) CpCap1W_1099 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) CpCap1W_1100 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) CpCap1W_1105 ENOG4105CUC YeeE YedE family protein CpCap1W_1106 ENOG4105DFA alanine racemase domain protein CpCap1W_1109 ENOG4108JQ5 ABC transporter CpCap1W_1110 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component CpCap1W_1112 ENOG4105DEF Extracellular solute-binding protein, family 5 CpCap1W_1115 ENOG4105C94 Transporter CpCap1W_1117 ENOG4105DEN Luciferase family CpCap1W_1118 ENOG4105CWM branched-chain amino acid transport system II carrier protein CpCap1W_1124 ENOG4105EBR Carboxylesterase CpCap1W_1125 ENOG4105DGW oligopeptidase A CpCap1W_1129 ENOG4108IQE Amp-dependent synthetase and ligase CpCap1W_1141 ENOG4106DBE Involved in DNA repair and RecF pathway recombination (By similarity) CpCap1W_1146 ENOG4105D9H Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) CpCap1W_1159 ENOG4105EN6 Membrane CpCap1W_1165 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) CpCap1W_1168 ENOG4105DH2 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity) CpCap1W_1173 ENOG4105EGD dinuclear metal center protein, YbgI family CpCap1W_1175 ENOG4105CVJ phosphoglycerate mutase CpCap1W_1177 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) CpCap1W_1182 ENOG4105C5F glutamine synthetase CpCap1W_1187 ENOG4105D98 threonine synthase CpCap1W_1189 ENOG4105E09 nadh pyrophosphatase CpCap1W_1190 ENOG4105D3Y Na H antiporter CpCap1W_1207 ENOG4107QMH DNA methylase CpCap1W_1221 ENOG4105C5F glutamine synthetase CpCap1W_1228 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) CpCap1W_1229 ENOG4105CBI The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor CpCap1W_1233 ENOG4105CM2 brancheD-chain amino acid aminotransferase CpCap1W_1235 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) CpCap1W_1236 ENOG4108YZT Adenosylcobinamide kinase CpCap1W_1247 ENOG4105K4H Nlp p60 protein CpCap1W_1249 ENOG4105JNK Glycosyl transferase (Group 1 CpCap1W_1250 ENOG4105DKQ ROK family CpCap1W_1254 ENOG4105C7V phospho-2-dehydro-3-deoxyheptonate aldolase CpCap1W_1256 ENOG4105KYH transcriptional regulatory protein CpCap1W_1257 ENOG41072RD Membrane CpCap1W_1268 ENOG4105CJN penicillin-binding protein CpCap1W_1269 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) CpCap1W_1276 ENOG4105DFU Cell wall formation (By similarity) CpCap1W_1278 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) CpCap1W_1279 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase CpCap1W_1280 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) CpCap1W_1283 ENOG4107VQS DivIVA family CpCap1W_1287 ENOG4105HDK L-asparaginase CpCap1W_1295 ENOG4105C7B Threonine dehydratase CpCap1W_1296 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein CpCap1W_1302 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) CpCap1W_1315 ENOG4108MWI inositol mono-phosphatase CpCap1W_1319 ENOG4105DK0 Indole-3-glycerol phosphate synthase CpCap1W_1321 ENOG4105CA9 Pyruvate kinase CpCap1W_1326 ENOG4105CH2 amidohydrolase CpCap1W_1329 ENOG4105BZW Glycerate kinase CpCap1W_1330 ENOG4107R37 Glutamate dehydrogenase CpCap1W_1331 ENOG4105DCF alanine dehydrogenase CpCap1W_1336 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) CpCap1W_1343 ENOG4105E1P Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity) CpCap1W_1347 ENOG4107XUM An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) CpCap1W_1348 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) CpCap1W_1350 ENOG4105DM4 PTS System CpCap1W_1353 ENOG4107QYR Signal peptidase i CpCap1W_1357 ENOG4105C0P Mg chelatase subunit ChlI CpCap1W_1359 ENOG4108IYT Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) CpCap1W_1368 ENOG41068X0 Protein of unknown function (DUF2631) CpCap1W_1371 ENOG4105DZP Membrane-associated zinc metalloprotease CpCap1W_1383 ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase CpCap1W_1385 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) CpCap1W_1386 ENOG4105CKI cobalamin synthesis protein CpCap1W_1387 ENOG4105CNG UPF0061 protein CpCap1W_1388 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) CpCap1W_1389 ENOG4107XFJ UPF0246 protein CpCap1W_1398 ENOG4107QMU Mate efflux family protein CpCap1W_1401 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) CpCap1W_1409 ENOG4105CN5 Metallo-Beta-Lactamase CpCap1W_1416 ENOG4105WBV Transcriptional regulator CpCap1W_1418 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) CpCap1W_1419 ENOG4108JJB ABC transporter CpCap1W_1420 ENOG4107ZYJ bioY protein CpCap1W_1427 ENOG4105C99 atpase involved in dna repair CpCap1W_1430 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) CpCap1W_1433 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) CpCap1W_1434 ENOG4105C2W permease CpCap1W_1436 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone CpCap1W_1437 ENOG4105KRI phosphocarrier protein (HPr CpCap1W_1439 ENOG4105DM4 PTS System CpCap1W_1440 ENOG4105DE4 1-phosphofructokinase CpCap1W_1441 ENOG4105E98 transcriptional regulator DeoR family CpCap1W_1442 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) CpCap1W_1443 ENOG4105E98 transcriptional regulator DeoR family CpCap1W_1448 ENOG4105CQ7 ATP-dependent helicase CpCap1W_1450 ENOG4105C5Q Transcriptional regulator CpCap1W_1452 ENOG4105D3R alkyl hydroperoxide reductase CpCap1W_1453 ENOG4105JNJ Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) CpCap1W_1461 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) CpCap1W_1478 ENOG4107JTW chlorite dismutase CpCap1W_1479 ENOG4105E0X reductase CpCap1W_1491 ENOG4105DBE peroxidase CpCap1W_1495 ENOG4107YQ3 lipid a biosynthesis lauroyl acyltransferase CpCap1W_1498 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) CpCap1W_1501 ENOG4105C29 acyl-CoA thioesterase CpCap1W_1509 ENOG4107RTU Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) CpCap1W_1512 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) CpCap1W_1515 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) CpCap1W_1516 ENOG4105C5X domain protein CpCap1W_1522 ENOG4105EJQ L-serine dehydratase CpCap1W_1523 ENOG4108UZX fmn reductase CpCap1W_1533 ENOG41080G3 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) CpCap1W_1537 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase CpCap1W_1541 ENOG4105DC7 peptidase M24 CpCap1W_1549 ENOG4105CD3 dihydroorotase CpCap1W_1551 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain CpCap1W_1560 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) CpCap1W_1563 ENOG4105DJV ribulose-phosphate 3-epimerase CpCap1W_1569 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) CpCap1W_1571 ENOG4105CHW UPF0052 protein CpCap1W_1573 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase CpCap1W_1581 ENOG4107QQX Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) CpCap1W_1582 ENOG4105CV1 Transketolase (EC 2.2.1.1) CpCap1W_1587 ENOG4107JC6 Membrane CpCap1W_1591 ENOG4105C3K feS assembly ATPase SufC CpCap1W_1593 ENOG4108UNV SUF system FeS assembly protein, NifU family CpCap1W_1594 ENOG4105VG1 fes assembly suf system protein CpCap1W_1599 ENOG4105CAG UPF0210 protein CpCap1W_1606 ENOG4105ZXU NLP P60 protein CpCap1W_1619 ENOG4105C5H ABC transporter CpCap1W_1622 ENOG4105CMT Dihydroxyacetone kinase CpCap1W_1623 ENOG4108UTZ Dihydroxyacetone kinase CpCap1W_1628 ENOG4107QYT Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) CpCap1W_1630 ENOG4107SET aldo keto reductase CpCap1W_1634 ENOG4105C3R Methionine synthase CpCap1W_1638 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter CpCap1W_1640 ENOG4108IJ0 Aspartate ammonia-lyase CpCap1W_1645 ENOG4105DFM M18 family aminopeptidase CpCap1W_1648 ENOG4105E5F proteasome CpCap1W_1652 ENOG4107TMB Transcriptional regulator CpCap1W_1654 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) CpCap1W_1657 ENOG4108RG3 short-chain dehydrogenase reductase CpCap1W_1664 ENOG4105CTK cobaltochelatase, cobn subunit CpCap1W_1667 ENOG4106N3V dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83) CpCap1W_1672 ENOG4105CSH Transporter CpCap1W_1676 ENOG4105D7N magnesium and cobalt transport protein CorA CpCap1W_1678 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) CpCap1W_1679 ENOG4105C1J atp-dependent rna helicase CpCap1W_1680 ENOG4105C37 (CBS) domain CpCap1W_1688 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving CpCap1W_1691 ENOG4105K5B UPF0225 protein CpCap1W_1703 ENOG4105DUU IucA IucC family protein CpCap1W_1704 ENOG4105E0A ABC, transporter CpCap1W_1705 ENOG4108U1V ABC transporter, permease CpCap1W_1706 ENOG4105DQ5 transport system permease protein CpCap1W_1707 ENOG4108HUF Transporter CpCap1W_1708 ENOG4105FF5 Membrane CpCap1W_1709 ENOG4108SEA Esterase CpCap1W_1711 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter CpCap1W_1712 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) CpCap1W_1715 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) CpCap1W_1717 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) CpCap1W_1718 ENOG4105DUX Transporter CpCap1W_1720 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) CpCap1W_1722 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) CpCap1W_1730 ENOG4105DSU hydrolase CpCap1W_1737 ENOG4105W49 UPF0434 protein CpCap1W_1738 ENOG4105CH7 arginosuccinase CpCap1W_1742 ENOG4105C8Y Acetylornithine aminotransferase CpCap1W_1745 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase CpCap1W_1751 ENOG41084BS 50S ribosomal protein L35 CpCap1W_1754 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) CpCap1W_1756 ENOG4105EEM helicase CpCap1W_1760 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) CpCap1W_1762 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) CpCap1W_1763 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) CpCap1W_1768 ENOG4105E5Q amino acid AbC transporter CpCap1W_1769 ENOG4108JEH abc transporter atp-binding protein CpCap1W_1774 ENOG4106H78 methyltransferase CpCap1W_1775 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit CpCap1W_1777 ENOG4105DP4 dak2 domain fusion protein ylov CpCap1W_1778 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) CpCap1W_1779 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) CpCap1W_1798 ENOG4105ERH Fumarylacetoacetate hydrolase CpCap1W_1802 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) CpCap1W_1815 ENOG4105CXD Specific inhibitor of chromosomal initiation of replication in vitro. Binds the three 13-mers in the origin (oriC) to block initiation of replication (By similarity) CpCap1W_1817 ENOG4105CPC Aldo Keto reductase CpCap1W_1819 ENOG4105CTQ phosphohexokinase CpCap1W_1821 ENOG4105E0A ABC, transporter CpCap1W_1822 ENOG4105EHG Permease protein CpCap1W_1835 ENOG4105C10 Electron transfer flavoprotein CpCap1W_1839 ENOG4105DKW ABC transporter CpCap1W_1853 ENOG4107Z0K Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) (By similarity) CpCap1W_1854 ENOG4105ZA1 atp synthase CpCap1W_1855 ENOG4107UH5 it plays a direct role in the translocation of protons across the membrane (By similarity) CpCap1W_1866 ENOG4105D6E homoserine dehydrogenase CpCap1W_1867 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) CpCap1W_1869 ENOG4105DAA L-lactate CpCap1W_1870 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) CpCap1W_1871 ENOG4107QR9 Iron-sulfur cluster binding protein CpCap1W_1872 ENOG41080R8 Conserved Protein CpCap1W_1877 ENOG4105FS7 Transcriptional regulator CpCap1W_1882 ENOG4105C0D helicase CpCap1W_1883 ENOG4105CK7 Sodium proline symporter CpCap1W_1890 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) CpCap1W_1894 ENOG4107WI4 Aldose-1-epimerase CpCap1W_1898 ENOG4105EBR Carboxylesterase CpCap1W_1899 ENOG4105F9E Shikimate 5-dehydrogenase CpCap1W_1901 ENOG4105BZ1 (ABC) transporter CpCap1W_1902 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 CpCap1W_1904 ENOG4105CJW magnesium transporter CpCap1W_1910 ENOG4107ZBN O-methyltransferase CpCap1W_1912 ENOG4107QPH glycogen) synthase CpCap1W_1913 ENOG4107FQX Alpha-acetolactate decarboxylase CpCap1W_1918 ENOG4105C3Q Glycosyl transferase, family 2 CpCap1W_1919 ENOG4105EEI dihydropteroate synthase CpCap1W_1923 ENOG4105C85 amino acid CpCap1W_1925 ENOG4105C85 amino acid CpCap1W_1929 ENOG4108Z4U Ferredoxin CpCap1W_1933 ENOG4105CI3 gtp-binding protein typa CpCap1W_1937 ENOG4108TVX serine protease CpCap1W_1939 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component CpCap1W_1940 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component CpCap1W_1941 ENOG4108J59 Extracellular solute-binding protein, family 5 CpCap1W_1943 ENOG4105CAT Cytidine monophosphate kinase CpCap1W_1945 ENOG4108JJB ABC transporter CpCap1W_1946 ENOG4105NSK ABC superfamily ATP binding cassette transporter membrane protein CpCap1W_1948 ENOG4105CKW Inner membrane protein yedI CpCap1W_1949 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) CpCap1W_1951 ENOG4105BZ1 (ABC) transporter CpCap1W_1952 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA CpCap1W_1955 ENOG4105C3G gtp-binding protein CpCap1W_1977 ENOG4105T1M mycothiol conjugate amidase mca CpCap1W_1991 ENOG4105DXN mazG family CpCap1W_1992 ENOG4105D5Q Arginine ornithine antiporter CpCap1W_1994 ENOG41082JN Transcriptional regulator CpCap1W_1997 ENOG4107TZ2 Cell division protein that is required for growth during stress conditions. May be involved in protecting or stabilizing the divisomal assembly under conditions of stress (By similarity) CpCap1W_1998 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) CpCap1W_1999 ENOG4105C5T Phosphoribosyl pyrophosphate synthase CpCap1W_2000 ENOG4108IUM Glycogen debranching enzyme CpCap1W_2003 ENOG4105EA8 2-Nitropropane dioxygenase CpCap1W_2004 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) CpCap1W_2006 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) CpCap1W_2007 ENOG4108HGY Proline imino-peptidase CpCap1W_2016 ENOG4105CSR polyphosphate kinase 2 CpCap1W_2019 ENOG4105C5H ABC transporter CpCap1W_2022 ENOG4106839 domain protein CpCap1W_2023 ENOG4105F8V Hydrolase, tatD family CpCap1W_2026 ENOG4108K88 Membrane CpCap1W_2027 ENOG4105C94 Transporter CpCap1W_2029 ENOG4105FF9 glycosyl transferase, family 39 CpCap1W_2031 ENOG4108VGI doxx family CpCap1W_2035 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase CpCap1W_2040 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) CpCap1W_2041 ENOG4105C0H protease CpCap1W_2042 ENOG41062D9 Histidine kinase CpCap1W_2043 ENOG4105ETX regulatoR CpCap1W_2045 ENOG4105NRA 50s ribosomal protein l31 type b CpCap1W_2051 ENOG4105EC0 Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity) CpCap1W_2053 ENOG4105DRP amino acid AbC transporter CpCap1W_2054 ENOG4108Q1T ABC transporter CpCap1W_2055 ENOG4107UBR Extracellular solute-binding protein family 3 CpCap1W_2056 ENOG4105CDA abc transporter atp-binding protein CpCap1W_2060 ENOG41061JJ Peptidase family M23 CpCap1W_2066 ENOG4108S0J Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized pyrimidines, such as thymine glycol, 5,6-dihydrouracil and 5,6-dihydrothymine. Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'- phosphates (By similarity) CpCap1W_2068 ENOG4107QRT dEAD DEAH box helicase CpCap1W_2069 ENOG4108RM3 Phosphatase with a broad specificity. Its primary physiological function is to dephosphorylate 3'-phosphoadenosine 5'-phosphate (PAP) and 3'-phosphoadenosine 5'-phosphosulfate (PAPS). Thus, plays a role in mycobacterial sulfur metabolism, since it can serve as a key regulator of the sulfate assimilation pathway by controlling the pools of PAP and PAPS in the cell. To a lesser extent, is also able to hydrolyze inositol 1-phosphate (I- 1-P), fructose 1,6-bisphosphate (FBP) (to fructose 6-phosphate (F- 6-P)) and AMP in vitro, but this might has no significance in vivo CpCap1W_2076 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) CpCap1W_2079 ENOG4108J59 Extracellular solute-binding protein, family 5 CpCap1W_2084 ENOG4107QI1 Mate efflux family protein CpCap1W_2088 ENOG4108WKN secreted protein CpCap1W_2090 ENOG4107QN1 sodium solute CpCap1W_2092 ENOG4108VUG Enoyl-CoA hydratase CpCap1W_2093 ENOG4105CV8 reductase CpCap1W_2097 ENOG41081K0 peptidylprolyl cis-trans isomerase CpCap1W_2098 ENOG4105BZN citrate synthase CpCap1W_2102 ENOG4105FCS tRNA rRNA methyltransferase CpCap1W_2103 ENOG4105C7N Xanthine uracil vitamin C permease CpCap1W_2109 ENOG4105MS9 Resuscitation-promoting factor CpCap1W_2111 ENOG4105CFI type iii restriction protein res subunit CpCap1W_2119 ENOG4105DVE abc transporter atp-binding protein CpCap1W_2124 ENOG41080RH Thioredoxin CpCap1W_2127 ENOG41079KZ Major Facilitator Superfamily CpCap1W_2129 ENOG4105BZP glycoside hydrolase 15-related CpCap1W_2132 ENOG4107YH6 single-stranded DNA-binding protein CpCap1W_2136 ENOG4105BZ4 penicillin-binding protein CpCap1W_2140 ENOG4108RKS Short-chain dehydrogenase reductase Sdr CpCap1W_2143 ENOG4107XFB conserved TRANSMEMBRANE PROTEIN CpCap1W_2144 ENOG4105DPV During stationary phase, binds the chromosome non- specifically, forming a highly ordered and stable dps-DNA co- crystal within which chromosomal DNA is condensed and protected from diverse damages. It protects DNA from oxidative damage by sequestering intracellular Fe(2 ) ion and storing it in the form of Fe(3 ) oxyhydroxide mineral, which can be released after reduction. One hydrogen peroxide oxidizes two Fe(2 ) ions, which prevents hydroxyl radical production by the Fenton reaction CpCap1W_2145 ENOG4108S0J Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized pyrimidines, such as thymine glycol, 5,6-dihydrouracil and 5,6-dihydrothymine. Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'- phosphates (By similarity) CpCap1W_2148 ENOG4105ECB domain protein CpCap1W_2152 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) CpCap1W_2156 ENOG4105ENE Histidine kinase CpCap1W_2157 ENOG4105WH1 Two component transcriptional regulator luxr family CpCap1W_2161 ENOG4105CE4 GlcNAc 6-P deacetylase CpCap1W_2164 ENOG4107EJG GntR family transcriptional regulator CpCap1W_2165 ENOG4105DEF Extracellular solute-binding protein, family 5 CpCap1W_2166 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component CpCap1W_2168 ENOG4108JQ7 (ABC) transporter CpCap1W_2169 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) CpCap1W_2176 ENOG4106178 UPF0339 protein CpCap1W_2179 ENOG4107QV7 Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system) (By similarity) CpCap1W_2181 ENOG4105EWK phytoene CpCap1W_2183 ENOG4105CRQ synthase (Component I) CpCap1W_2184 ENOG4105RGK anthranilate synthase component ii CpCap1W_2186 ENOG4105DK0 Indole-3-glycerol phosphate synthase CpCap1W_2191 ENOG4105DHU Bile acid CpCap1W_2193 ENOG4105KMT branched-chain amino acid CpCap1W_2194 ENOG4108UMN azlc family CpCap1W_2195 ENOG4108UJU UPF0301 protein CpCap1W_2196 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate CpCap1W_2201 ENOG4105EMN RNA polymerase sigma factor CpCap1W_2202 ENOG4105C3M thioredoxin reductase CpCap1W_2203 ENOG4105K63 Thioredoxin CpCap1W_2204 ENOG4108E1C hydrolase CpCap1W_2207 ENOG4107QJE Chromosome Partitioning Protein CpCap1W_2213 ENOG41084CH 50S ribosomal protein l34