locus-tag class description Cp162_0002 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) Cp162_0005 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) Cp162_0009 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) Cp162_0015 ENOG4107SDZ Galactoside transport system permease protein mglC Cp162_0016 ENOG4105C2J ABC transporter Cp162_0028 ENOG4105E0A ABC, transporter Cp162_0029 ENOG4105TVJ transport system, permease Cp162_0030 ENOG4105DQ5 transport system permease protein Cp162_0031 ENOG4108MES Periplasmic binding protein Cp162_0032 ENOG4105XBB septation inhibitor protein Cp162_0033 ENOG4108DT4 serine threonine protein kinase Cp162_0035 ENOG4105CJN penicillin-binding protein Cp162_0039 ENOG4105TV9 FHA Domain-Containing protein Cp162_0039 ENOG4105TV9 FHA Domain-Containing protein Cp162_0044 ENOG4105CJW magnesium transporter Cp162_0046 ENOG4105CG3 alpha amylase, catalytic region Cp162_0054 ENOG4105K6V RNA polymerase Cp162_0061 ENOG4108IJ8 ABC transporter Cp162_0066 ENOG41066NP positive regulation by symbiont of host immune response Cp162_0068 ENOG4105FYV Amp nucleosidase Cp162_0076 ENOG4108Z0R Transferase Cp162_0080 ENOG4108URH decarboxylase Cp162_0082 ENOG4105K56 Transcriptional regulator Cp162_0087 ENOG4105EJ9 Membrane Cp162_0090 ENOG4105CQ7 ATP-dependent helicase Cp162_0091 ENOG4105CF1 Alkylated DNA repair protein Cp162_0092 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) Cp162_0094 ENOG4105K8R UPF0145 protein Cp162_0095 ENOG410848D S4 domain protein YaaA Cp162_0099 ENOG4108JQ0 Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) Cp162_0100 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) Cp162_0102 ENOG4105C9K Endothelin-converting enzyme 1 Cp162_0106 ENOG4105J1Z Arabinosyltransferase Cp162_0107 ENOG4108K7T Involved in the biosynthesis of the arabinogalactan (AG) region of the mycolylarabinogalactan-peptidoglycan (mAGP) complex, an essential component the mycobacterial cell wall. Catalyzes the addition of the first key arabinofuranosyl (Araf) residue from the sugar donor beta-D-arabinofuranosyl-1-monophosphoryldecaprenol (DPA) on the C-5 of a 6-linked galactofuranosyl (Galf) of the galactan domain, thus 'priming' the galactan for further elaboration by other arabinofuranosyltransferases Cp162_0108 ENOG4108RG3 short-chain dehydrogenase reductase Cp162_0109 ENOG4105IQ5 FAD linked oxidase domain protein Cp162_0115 ENOG4108MKI Glycosyl transferase, family 2 Cp162_0116 ENOG4107SIG periplasmic solute binding protein Cp162_0117 ENOG4105DIK (ABC) transporter Cp162_0118 ENOG4107RPQ ABC transporter Cp162_0119 ENOG4107RBD ABC, transporter Cp162_0120 ENOG4107SIG periplasmic solute binding protein Cp162_0125 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein Cp162_0131 ENOG4105DSQ Nitric oxide reductase Cp162_0133 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family Cp162_0136 ENOG4105EVN Prephenate dehydrogenase Cp162_0138 ENOG4108Z6B deaminase Cp162_0140 ENOG4105EYF MMPL domain protein Cp162_0141 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) Cp162_0143 ENOG4105C6Z Gluconate Cp162_0144 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family Cp162_0145 ENOG4105CPQ Dehydrogenase Cp162_0146 ENOG4105CHR reductase Cp162_0148 ENOG4105XT2 Transcriptional regulator Cp162_0153 ENOG4105C6Z Gluconate Cp162_0154 ENOG4105ZXK Dehydrogenase Cp162_0157 ENOG4105ERH Fumarylacetoacetate hydrolase Cp162_0160 ENOG4105F1K Glutamine amidotransferase Cp162_0161 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) Cp162_0163 ENOG4108DBC nitroreductase Cp162_0165 ENOG4107RHR regulatoR Cp162_0166 ENOG4105D3A purine nucleoside phosphorylase DeoD-type Cp162_0169 ENOG4107QSU Phosphoglucomutase phosphomannomutase alpha beta alpha domain Cp162_0171 ENOG4105DUY Ser-Asp rich fibrinogen-binding, bone sialoprotein-binding protein Cp162_0173 ENOG4105PP6 Membrane Cp162_0174 ENOG4105CFH Aspartokinase Cp162_0175 ENOG4105DUY Ser-Asp rich fibrinogen-binding, bone sialoprotein-binding protein Cp162_0178 ENOG4105CH6 catalase Cp162_0183 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) Cp162_0185 ENOG4107QKW extracellular solute-binding protein family 1 Cp162_0186 ENOG4105CXY transporter Cp162_0187 ENOG4105CK6 Two component transcriptional regulator (Winged helix family Cp162_0192 ENOG4108JPZ Monovalent cation H antiporter subunit D Cp162_0194 ENOG4105D65 subunit l Cp162_0196 ENOG4108NJC Cp162_0199 ENOG4105BZ4 penicillin-binding protein Cp162_0200 ENOG4105N0U Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) Cp162_0204 ENOG4105IJJ transcriptional regulator, crp fnr family Cp162_0208 ENOG4105P8F nudix hydrolase Cp162_0221 ENOG4108I5C dEAD DEAH box helicase Cp162_0223 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) Cp162_0224 ENOG4105EPD Oligopeptide transporter, Opt family Cp162_0226 ENOG4107QRG dna polymerase iii Cp162_0228 ENOG4105CEY Amp-dependent synthetase and ligase Cp162_0230 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) Cp162_0232 ENOG4105C1B dTDP-glucose 4-6-dehydratase Cp162_0237 ENOG4107QN2 dihydrolipoyl dehydrogenase Cp162_0238 ENOG4105CFF transcriptional regulator Cp162_0241 ENOG4105E33 succinate dehydrogenase Cp162_0243 ENOG4106BRA Membrane Cp162_0245 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) Cp162_0249 ENOG4105C6N Formate acetyltransferase Cp162_0253 ENOG4105CEY Amp-dependent synthetase and ligase Cp162_0257 ENOG4105CK6 Two component transcriptional regulator (Winged helix family Cp162_0262 ENOG4105II7 pyrroline-5-carboxylate reductase Cp162_0266 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) Cp162_0268 ENOG4108RXW HAD-superfamily subfamily IB hydrolase Cp162_0272 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) Cp162_0275 ENOG4105C59 p-type ATPase Cp162_0277 ENOG4105C1Q protoporphyrinogen oxidase Cp162_0280 ENOG4108RH7 phosphoglycerate mutase Cp162_0282 ENOG4107QIV Cytochrome c biogenesis protein Cp162_0284 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) Cp162_0287 ENOG4105EHG Permease protein Cp162_0288 ENOG4105CRE cytochrome C Cp162_0295 ENOG4107TCW O-succinylbenzoate synthase Cp162_0300 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) Cp162_0301 ENOG4105P52 geranylgeranyl reductase Cp162_0303 ENOG410683Z Preprotein translocase SecE subunit Cp162_0308 ENOG4105CTZ aminopeptidase c Cp162_0309 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase Cp162_0313 ENOG4105DSE periplasmic solute binding protein Cp162_0315 ENOG4105DIK (ABC) transporter Cp162_0316 ENOG4105CC5 ABC transporter Cp162_0321 ENOG4105BZU Histidine kinase Cp162_0322 ENOG4105WH1 Two component transcriptional regulator luxr family Cp162_0324 ENOG4105CJ1 ABC, transporter Cp162_0327 ENOG4108PJD permease Cp162_0341 ENOG4105VBF alkaline shock protein Cp162_0342 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) Cp162_0362 ENOG4105C44 Serine transporter Cp162_0363 ENOG4105EJQ L-serine dehydratase Cp162_0365 ENOG4105HDK L-asparaginase Cp162_0367 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) Cp162_0378 ENOG4105EG2 ABC transporter, permease Cp162_0382 ENOG4108IJ9 (ABC) transporter Cp162_0383 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) Cp162_0393 ENOG4108ZT0 50S ribosomal protein l17 Cp162_0399 ENOG4105EC2 ftsk spoIIIe Cp162_0411 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) Cp162_0423 ENOG4108VT4 Cp162_0425 ENOG4107QVP Dehydrogenase Cp162_0434 ENOG4108UMI ABC transporter, permease Cp162_0436 ENOG4105D01 (LipO)protein Cp162_0437 ENOG4105D01 (LipO)protein Cp162_0440 ENOG4105DSE periplasmic solute binding protein Cp162_0441 ENOG4105DIK (ABC) transporter Cp162_0442 ENOG4107RBD ABC, transporter Cp162_0443 ENOG4107RPQ ABC transporter Cp162_0444 ENOG4107R5H iron (metal) dependent repressor, dtxr family Cp162_0445 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) Cp162_0446 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) Cp162_0454 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) Cp162_0456 ENOG4108IQK o-acetylhomoserine Cp162_0457 ENOG4105E9K Isocitrate dehydrogenase Cp162_0458 ENOG4105F27 Major Facilitator Cp162_0462 ENOG4105C31 Tryptophanyl-tRNA synthetase Cp162_0463 ENOG4107H3J ribonuclease Cp162_0464 ENOG4105DZ1 carboxypeptidase Cp162_0471 ENOG4107QSU Phosphoglucomutase phosphomannomutase alpha beta alpha domain Cp162_0472 ENOG4107RM1 amidohydrolase Cp162_0474 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) Cp162_0477 ENOG4108JIK carboxylase Cp162_0478 ENOG4105KHC sulfurtransferase Cp162_0480 ENOG4105D7Z glutathione synthase Cp162_0481 ENOG4105EXC Acyl-transferase Cp162_0483 ENOG4107WR6 Maf-like protein Cp162_0484 ENOG4108RVA ribokinase Cp162_0485 ENOG4105ETE Transcriptional regulator (LacI family Cp162_0487 ENOG4105D8K carboxyl transferase Cp162_0488 ENOG4105D8K carboxyl transferase Cp162_0490 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase Cp162_0501 ENOG4107TB5 TRANSCRIPTIONal Cp162_0504 ENOG4105K51 Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) Cp162_0509 ENOG4105EIP mannose-6-phosphate isomerase Cp162_0516 ENOG4105CK6 Two component transcriptional regulator (Winged helix family Cp162_0517 ENOG4105BZU Histidine kinase Cp162_0520 ENOG4108S7Q sigma 54 modulation protein ribosomal protein S30ea Cp162_0528 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase Cp162_0529 ENOG4108RAV Conserved protein Cp162_0530 ENOG4108Z66 YbaK ebsC protein Cp162_0537 ENOG4105C1J atp-dependent rna helicase Cp162_0544 ENOG4105E09 nadh pyrophosphatase Cp162_0549 ENOG41063PX domain protein Cp162_0564 ENOG4105C85 amino acid Cp162_0565 ENOG4107QSA Oxaloacetate decarboxylase Cp162_0566 ENOG4107QX3 carboxylase Cp162_0568 ENOG4107QSA Oxaloacetate decarboxylase Cp162_0570 ENOG4107TK4 histidinol-phosphate phosphatase Cp162_0571 ENOG4107TK4 histidinol-phosphate phosphatase Cp162_0574 ENOG4105CFC Transporter Cp162_0575 ENOG4105CAK Cell division ATP-binding protein ftsE Cp162_0576 ENOG4107RYD Part of the ABC transporter FtsEX involved in cellular division (By similarity) Cp162_0579 ENOG4107B2H carbonic anhydrase Cp162_0583 ENOG4105CM4 permease protein Cp162_0584 ENOG4108IPW abc transporter atp-binding protein Cp162_0591 ENOG4105MS9 Resuscitation-promoting factor Cp162_0597 ENOG4105C7N Xanthine uracil vitamin C permease Cp162_0598 ENOG4105FCS tRNA rRNA methyltransferase Cp162_0603 ENOG4105BZN citrate synthase Cp162_0604 ENOG41081K0 peptidylprolyl cis-trans isomerase Cp162_0609 ENOG4105CV8 reductase Cp162_0610 ENOG4108VUG Enoyl-CoA hydratase Cp162_0612 ENOG4107QN1 sodium solute Cp162_0614 ENOG4108WKN secreted protein Cp162_0617 ENOG4107QI1 Mate efflux family protein Cp162_0622 ENOG4108J59 Extracellular solute-binding protein, family 5 Cp162_0623 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component Cp162_0625 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) Cp162_0631 ENOG4108RM3 Phosphatase with a broad specificity. Its primary physiological function is to dephosphorylate 3'-phosphoadenosine 5'-phosphate (PAP) and 3'-phosphoadenosine 5'-phosphosulfate (PAPS). Thus, plays a role in mycobacterial sulfur metabolism, since it can serve as a key regulator of the sulfate assimilation pathway by controlling the pools of PAP and PAPS in the cell. To a lesser extent, is also able to hydrolyze inositol 1-phosphate (I- 1-P), fructose 1,6-bisphosphate (FBP) (to fructose 6-phosphate (F- 6-P)) and AMP in vitro, but this might has no significance in vivo Cp162_0633 ENOG4107QRT dEAD DEAH box helicase Cp162_0635 ENOG4108S0J Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized pyrimidines, such as thymine glycol, 5,6-dihydrouracil and 5,6-dihydrothymine. Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'- phosphates (By similarity) Cp162_0641 ENOG41061JJ Peptidase family M23 Cp162_0645 ENOG4105CDA abc transporter atp-binding protein Cp162_0646 ENOG4107UBR Extracellular solute-binding protein family 3 Cp162_0647 ENOG4108Q1T ABC transporter Cp162_0648 ENOG4105DRP amino acid AbC transporter Cp162_0650 ENOG4105EC0 Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity) Cp162_0656 ENOG4105NRA 50s ribosomal protein l31 type b Cp162_0658 ENOG4105ETX regulatoR Cp162_0659 ENOG41062D9 Histidine kinase Cp162_0660 ENOG4105C0H protease Cp162_0661 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) Cp162_0665 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase Cp162_0669 ENOG4108VGI doxx family Cp162_0671 ENOG4105FF9 glycosyl transferase, family 39 Cp162_0672 ENOG4105C94 Transporter Cp162_0673 ENOG4108K88 Membrane Cp162_0676 ENOG4105F8V Hydrolase, tatD family Cp162_0677 ENOG4106839 domain protein Cp162_0680 ENOG4105C5H ABC transporter Cp162_0683 ENOG4105CSR polyphosphate kinase 2 Cp162_0685 ENOG410667J hydrolase Cp162_0694 ENOG4108HGY Proline imino-peptidase Cp162_0695 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) Cp162_0697 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) Cp162_0698 ENOG4105EA8 2-Nitropropane dioxygenase Cp162_0702 ENOG4108IUM Glycogen debranching enzyme Cp162_0703 ENOG4105C5T Phosphoribosyl pyrophosphate synthase Cp162_0704 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) Cp162_0705 ENOG4107TZ2 Cell division protein that is required for growth during stress conditions. May be involved in protecting or stabilizing the divisomal assembly under conditions of stress (By similarity) Cp162_0707 ENOG41082JN Transcriptional regulator Cp162_0709 ENOG4105D5Q Arginine ornithine antiporter Cp162_0710 ENOG4105DXN mazG family Cp162_0722 ENOG4105T1M mycothiol conjugate amidase mca Cp162_0744 ENOG4105C3G gtp-binding protein Cp162_0746 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA Cp162_0747 ENOG4105BZ1 (ABC) transporter Cp162_0748 ENOG4105BZ1 (ABC) transporter Cp162_0749 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) Cp162_0750 ENOG4105CKW Inner membrane protein yedI Cp162_0752 ENOG4105NSK ABC superfamily ATP binding cassette transporter membrane protein Cp162_0753 ENOG4108JJB ABC transporter Cp162_0755 ENOG4105CAT Cytidine monophosphate kinase Cp162_0757 ENOG4108J59 Extracellular solute-binding protein, family 5 Cp162_0758 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component Cp162_0759 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component Cp162_0761 ENOG4108TVX serine protease Cp162_0766 ENOG4105CI3 gtp-binding protein typa Cp162_0770 ENOG4108Z4U Ferredoxin Cp162_0774 ENOG4105C85 amino acid Cp162_0776 ENOG4105C85 amino acid Cp162_0780 ENOG4105EEI dihydropteroate synthase Cp162_0781 ENOG4105C3Q Glycosyl transferase, family 2 Cp162_0786 ENOG4107FQX Alpha-acetolactate decarboxylase Cp162_0787 ENOG4107QPH glycogen) synthase Cp162_0789 ENOG4107ZBN O-methyltransferase Cp162_0795 ENOG4105CJW magnesium transporter Cp162_0797 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 Cp162_0798 ENOG4105BZ1 (ABC) transporter Cp162_0800 ENOG4105F9E Shikimate 5-dehydrogenase Cp162_0801 ENOG4105EBR Carboxylesterase Cp162_0805 ENOG4107WI4 Aldose-1-epimerase Cp162_0809 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) Cp162_0815 ENOG4105CK7 Sodium proline symporter Cp162_0816 ENOG4105C0D helicase Cp162_0821 ENOG4105FS7 Transcriptional regulator Cp162_0824 ENOG4105E98 transcriptional regulator DeoR family Cp162_0826 ENOG41080R8 Conserved Protein Cp162_0827 ENOG4107QR9 Iron-sulfur cluster binding protein Cp162_0828 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) Cp162_0829 ENOG4105DAA L-lactate Cp162_0831 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) Cp162_0832 ENOG4105D6E homoserine dehydrogenase Cp162_0843 ENOG4107UH5 it plays a direct role in the translocation of protons across the membrane (By similarity) Cp162_0844 ENOG4105ZA1 atp synthase Cp162_0845 ENOG4107Z0K Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) (By similarity) Cp162_0858 ENOG4105DKW ABC transporter Cp162_0862 ENOG4105C10 Electron transfer flavoprotein Cp162_0875 ENOG4105EHG Permease protein Cp162_0876 ENOG4105E0A ABC, transporter Cp162_0878 ENOG4105CTQ phosphohexokinase Cp162_0880 ENOG4105CPC Aldo Keto reductase Cp162_0882 ENOG4105CXD Specific inhibitor of chromosomal initiation of replication in vitro. Binds the three 13-mers in the origin (oriC) to block initiation of replication (By similarity) Cp162_0895 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) Cp162_0899 ENOG4105ERH Fumarylacetoacetate hydrolase Cp162_0913 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) Cp162_0914 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) Cp162_0915 ENOG4105DP4 dak2 domain fusion protein ylov Cp162_0917 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit Cp162_0918 ENOG4106H78 methyltransferase Cp162_0922 ENOG4108JEH abc transporter atp-binding protein Cp162_0923 ENOG4105E5Q amino acid AbC transporter Cp162_0927 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) Cp162_0929 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) Cp162_0932 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) Cp162_0936 ENOG4105EEM helicase Cp162_0941 ENOG41084BS 50S ribosomal protein L35 Cp162_0947 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase Cp162_0950 ENOG4105C8Y Acetylornithine aminotransferase Cp162_0954 ENOG4105CH7 arginosuccinase Cp162_0955 ENOG4105W49 UPF0434 protein Cp162_0959 ENOG4105DSU hydrolase Cp162_0967 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) Cp162_0969 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) Cp162_0971 ENOG4105DUX Transporter Cp162_0972 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) Cp162_0974 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) Cp162_0977 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) Cp162_0978 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter Cp162_0980 ENOG4108SEA Esterase Cp162_0981 ENOG4105FF5 Membrane Cp162_0982 ENOG4108HUF Transporter Cp162_0983 ENOG4105DQ5 transport system permease protein Cp162_0984 ENOG4108U1V ABC transporter, permease Cp162_0985 ENOG4105E0A ABC, transporter Cp162_0986 ENOG4105DUU IucA IucC family protein Cp162_0988 ENOG4105K5B UPF0225 protein Cp162_0991 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving Cp162_0999 ENOG4105C37 (CBS) domain Cp162_1000 ENOG4105C1J atp-dependent rna helicase Cp162_1001 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) Cp162_1003 ENOG4105D7N magnesium and cobalt transport protein CorA Cp162_1008 ENOG4105CSH Transporter Cp162_1013 ENOG4106N3V dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83) Cp162_1016 ENOG4105CTK cobaltochelatase, cobn subunit Cp162_1024 ENOG4108RG3 short-chain dehydrogenase reductase Cp162_1027 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) Cp162_1029 ENOG4107TMB Transcriptional regulator Cp162_1033 ENOG4105E5F proteasome Cp162_1036 ENOG4105DFM M18 family aminopeptidase Cp162_1041 ENOG4108IJ0 Aspartate ammonia-lyase Cp162_1042 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter Cp162_1046 ENOG4105C3R Methionine synthase Cp162_1050 ENOG4107SET aldo keto reductase Cp162_1052 ENOG4107QYT Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) Cp162_1057 ENOG4108UTZ Dihydroxyacetone kinase Cp162_1058 ENOG4105CMT Dihydroxyacetone kinase Cp162_1059 ENOG4105C5H ABC transporter Cp162_1072 ENOG4105ZXU NLP P60 protein Cp162_1078 ENOG4105CAG UPF0210 protein Cp162_1083 ENOG4105VG1 fes assembly suf system protein Cp162_1084 ENOG4108UNV SUF system FeS assembly protein, NifU family Cp162_1086 ENOG4105C3K feS assembly ATPase SufC Cp162_1090 ENOG4107JC6 Membrane Cp162_1095 ENOG4105CV1 Transketolase (EC 2.2.1.1) Cp162_1096 ENOG4107QQX Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) Cp162_1104 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase Cp162_1106 ENOG4105CHW UPF0052 protein Cp162_1108 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) Cp162_1114 ENOG4105DJV ribulose-phosphate 3-epimerase Cp162_1117 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) Cp162_1126 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain Cp162_1128 ENOG4105CD3 dihydroorotase Cp162_1136 ENOG4105DC7 peptidase M24 Cp162_1140 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase Cp162_1143 ENOG4105HHA aminodeoxychorismate lyase Cp162_1144 ENOG41080G3 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) Cp162_1154 ENOG4108UZX fmn reductase Cp162_1155 ENOG4105EJQ L-serine dehydratase Cp162_1160 ENOG4105C5X domain protein Cp162_1161 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) Cp162_1164 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) Cp162_1167 ENOG4107RTU Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) Cp162_1178 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) Cp162_1181 ENOG4107YQ3 lipid a biosynthesis lauroyl acyltransferase Cp162_1185 ENOG4105DBE peroxidase Cp162_1191 ENOG4105E0X reductase Cp162_1192 ENOG4107JTW chlorite dismutase Cp162_1209 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) Cp162_1217 ENOG4105JNJ Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) Cp162_1218 ENOG4105D3R alkyl hydroperoxide reductase Cp162_1220 ENOG4105C5Q Transcriptional regulator Cp162_1222 ENOG4105CQ7 ATP-dependent helicase Cp162_1227 ENOG4105E98 transcriptional regulator DeoR family Cp162_1228 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) Cp162_1229 ENOG4105E98 transcriptional regulator DeoR family Cp162_1230 ENOG4105DE4 1-phosphofructokinase Cp162_1231 ENOG4105DM4 PTS System Cp162_1233 ENOG4105KRI phosphocarrier protein (HPr Cp162_1234 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone Cp162_1236 ENOG4105C2W permease Cp162_1237 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) Cp162_1240 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) Cp162_1243 ENOG4105C99 atpase involved in dna repair Cp162_1250 ENOG4107ZYJ bioY protein Cp162_1251 ENOG4108JJB ABC transporter Cp162_1252 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) Cp162_1254 ENOG4105WBV Transcriptional regulator Cp162_1262 ENOG4105CN5 Metallo-Beta-Lactamase Cp162_1270 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) Cp162_1273 ENOG4107QMU Mate efflux family protein Cp162_1282 ENOG4107XFJ UPF0246 protein Cp162_1283 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) Cp162_1285 ENOG4105CKI cobalamin synthesis protein Cp162_1286 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) Cp162_1288 ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase Cp162_1299 ENOG4105DZP Membrane-associated zinc metalloprotease Cp162_1302 ENOG41068X0 Protein of unknown function (DUF2631) Cp162_1311 ENOG4108IYT Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) Cp162_1316 ENOG4107QYR Signal peptidase i Cp162_1319 ENOG4105DM4 PTS System Cp162_1321 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) Cp162_1322 ENOG4107XUM An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) Cp162_1326 ENOG4105E1P Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity) Cp162_1331 ENOG4108375 Acylphosphatase (EC 3.6.1.7) Cp162_1333 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) Cp162_1338 ENOG4105DCF alanine dehydrogenase Cp162_1339 ENOG4107R37 Glutamate dehydrogenase Cp162_1340 ENOG4105BZW Glycerate kinase Cp162_1343 ENOG4105CH2 amidohydrolase Cp162_1346 ENOG4105CA9 Pyruvate kinase Cp162_1348 ENOG4105DK0 Indole-3-glycerol phosphate synthase Cp162_1352 ENOG4108MWI inositol mono-phosphatase Cp162_1365 ENOG4105DE5 Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity) Cp162_1371 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein Cp162_1372 ENOG4105C7B Threonine dehydratase Cp162_1377 ENOG4107ZIW This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) Cp162_1380 ENOG4105HDK L-asparaginase Cp162_1384 ENOG4107VQS DivIVA family Cp162_1386 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) Cp162_1387 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase Cp162_1388 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) Cp162_1390 ENOG4105DFU Cell wall formation (By similarity) Cp162_1397 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) Cp162_1398 ENOG4105CJN penicillin-binding protein Cp162_1409 ENOG41072RD Membrane Cp162_1410 ENOG4105KYH transcriptional regulatory protein Cp162_1412 ENOG4105C7V phospho-2-dehydro-3-deoxyheptonate aldolase Cp162_1416 ENOG4105DKQ ROK family Cp162_1417 ENOG4105JNK Glycosyl transferase (Group 1 Cp162_1419 ENOG4105K4H Nlp p60 protein Cp162_1430 ENOG4108YZT Adenosylcobinamide kinase Cp162_1431 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) Cp162_1433 ENOG4105CM2 brancheD-chain amino acid aminotransferase Cp162_1437 ENOG4105CBI The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor Cp162_1438 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) Cp162_1445 ENOG4105C5F glutamine synthetase Cp162_1451 ENOG4105D3Y Na H antiporter Cp162_1452 ENOG4105E09 nadh pyrophosphatase Cp162_1454 ENOG4105D98 threonine synthase Cp162_1460 ENOG4105C5F glutamine synthetase Cp162_1465 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) Cp162_1466 ENOG4105CVJ phosphoglycerate mutase Cp162_1468 ENOG4105EGD dinuclear metal center protein, YbgI family Cp162_1473 ENOG4105DH2 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity) Cp162_1476 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) Cp162_1482 ENOG4105EN6 Membrane Cp162_1494 ENOG4105D9H Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) Cp162_1499 ENOG4106DBE Involved in DNA repair and RecF pathway recombination (By similarity) Cp162_1510 ENOG4108IQE Amp-dependent synthetase and ligase Cp162_1514 ENOG4105DGW oligopeptidase A Cp162_1515 ENOG4105EBR Carboxylesterase Cp162_1520 ENOG4105BZ1 (ABC) transporter Cp162_1521 ENOG4105CWM branched-chain amino acid transport system II carrier protein Cp162_1522 ENOG4105DEN Luciferase family Cp162_1524 ENOG4105C94 Transporter Cp162_1527 ENOG4105DEF Extracellular solute-binding protein, family 5 Cp162_1529 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component Cp162_1530 ENOG4108JQ5 ABC transporter Cp162_1533 ENOG4105DFA alanine racemase domain protein Cp162_1534 ENOG4105CUC YeeE YedE family protein Cp162_1538 ENOG4108EU3 peptide transport system, permease Cp162_1541 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) Cp162_1542 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) Cp162_1546 ENOG4105CCF Lysine exporter protein (Lyse ygga) Cp162_1551 ENOG4105KQC Competence protein Cp162_1552 ENOG4107Z8D degv family Cp162_1553 ENOG4105CVJ phosphoglycerate mutase Cp162_1555 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) Cp162_1558 ENOG4105WD1 Membrane Cp162_1559 ENOG4105D0C transport protein Cp162_1564 ENOG4105C03 ribonuclease Cp162_1567 ENOG4105CIF Ornithine Cyclodeaminase Cp162_1569 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase Cp162_1577 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation Cp162_1581 ENOG4105EUB pirin domain protein Cp162_1583 ENOG4105MC2 DSBA oxidoreductase Cp162_1588 ENOG4105D8X mechanosensitive ion channel Cp162_1605 ENOG4108M15 ABC transporter Cp162_1606 ENOG4105E4J Cytochrome c oxidase caa3-type, assembly factor ctag-related protein Cp162_1607 ENOG4105D22 carbon starvation protein Cp162_1608 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin Cp162_1609 ENOG4105EMU Dehydrogenase Cp162_1612 ENOG4107UBC ErfK ybiS ycfS ynhG family protein Cp162_1614 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein Cp162_1615 ENOG4108RWI nicotinamidase Cp162_1624 ENOG4105WH1 Two component transcriptional regulator luxr family Cp162_1633 ENOG4108RQ5 Beta-lactamase domain-containing protein Cp162_1638 ENOG4107RKP Nicotinate phosphoribosyltransferase Cp162_1642 ENOG4105TZK CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. May be involved in the integration of spacer DNA into the CRISPR cassette (By similarity) Cp162_1650 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) Cp162_1652 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) Cp162_1653 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) Cp162_1654 ENOG4105WAZ (Glutaredoxin-like protein) NrdH Cp162_1656 ENOG4107RA1 nh(3)-dependent nad( ) synthetase Cp162_1660 ENOG4105C59 p-type ATPase Cp162_1666 ENOG4107QIX Phosphoglucomutase (EC 5.4.2.2 Cp162_1669 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) Cp162_1670 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) Cp162_1677 ENOG4105D7W serine acetyltransferase Cp162_1680 ENOG4105C4M (Ubiquinol oxidase) subunit I Cp162_1681 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii Cp162_1682 ENOG4108JJ9 ABC, transporter Cp162_1683 ENOG4108JJ9 ABC, transporter Cp162_1688 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) Cp162_1694 ENOG4105CBD Diacylglycerol kinase Cp162_1697 ENOG4106XY2 Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity) Cp162_1702 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) Cp162_1703 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) Cp162_1705 ENOG4108JIU phosphoribosylformylglycinamidine synthase ii Cp162_1706 ENOG4105D21 Phosphoribosylformylglycinamidine synthase I Cp162_1707 ENOG410839H phosphoribosylformylglycinamidine synthase Cp162_1708 ENOG4108V06 Glutathione peroxidase Cp162_1712 ENOG4105C83 adenylosuccinate lyase Cp162_1713 ENOG4107ZYR domain protein Cp162_1714 ENOG4105CZN Potassium uptake protein Cp162_1715 ENOG4105C12 Phosphoribosylglycinamide synthetase Cp162_1716 ENOG4107ZUX Histidine triad (HIT) protein Cp162_1718 ENOG4105BZU Histidine kinase Cp162_1719 ENOG4105CK6 Two component transcriptional regulator (Winged helix family Cp162_1720 ENOG4105C57 major facilitator superfamily Cp162_1725 ENOG4105C7K acetolactate synthase Cp162_1734 ENOG4105C2N RNA methyltransferase TrmH family group 3 Cp162_1738 ENOG4108VJ1 Transcriptional regulator (CarD family Cp162_1742 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) Cp162_1744 ENOG4108V9Q carbonic anhydrase Cp162_1748 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit Cp162_1750 ENOG41080V3 Major Facilitator superfamily Cp162_1751 ENOG4105DU0 nucleoside hydrolase Cp162_1754 ENOG4105CRK lysyL-tRNA synthetase Cp162_1758 ENOG4105C26 Dehydrogenase Cp162_1759 ENOG4105C94 Transporter Cp162_1761 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) Cp162_1767 ENOG4105EEI dihydropteroate synthase Cp162_1768 ENOG4105EUJ GTP cyclohydrolase i Cp162_1769 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) Cp162_1770 ENOG4108UGV hypoxanthine phosphoribosyltransferase Cp162_1773 ENOG4105F0N pyrophosphate phospho-hydrolase Cp162_1774 ENOG4105VFE sira family Cp162_1775 ENOG4107QJT sodium dicarboxylate symporter Cp162_1779 ENOG4105CSR polyphosphate kinase 2 Cp162_1784 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) Cp162_1789 ENOG4105MKQ Monovalent cation H antiporter subunit C Cp162_1790 ENOG4108JPZ Monovalent cation H antiporter subunit D Cp162_1794 ENOG4108U8T Mannosyltransferase Cp162_1798 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) Cp162_1799 ENOG4105KEG ribosomal-protein-alanine acetyltransferase Cp162_1800 ENOG4105CGK Exodeoxyribonuclease III Cp162_1801 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) Cp162_1806 ENOG4105CT1 (ABC) transporter Cp162_1809 ENOG4108IJ2 phosphate acetyltransferase Cp162_1812 ENOG4108HH9 Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR Cp162_1813 ENOG4105DYA Acts on guanine, xanthine and to a lesser extent hypoxanthine (By similarity) Cp162_1820 ENOG4105CRE cytochrome C Cp162_1821 ENOG4105EBH Required during biogenesis of c-type cytochromes (cytochrome c6 and cytochrome f) at the step of heme attachment (By similarity) Cp162_1823 ENOG4105EAU Plays a role in nitrite reduction (By similarity) Cp162_1824 ENOG4108W6G cytochrome C Cp162_1835 ENOG4105DUY Ser-Asp rich fibrinogen-binding, bone sialoprotein-binding protein Cp162_1836 ENOG4107RCW fructose-bisphosphate aldolase Cp162_1839 ENOG41065E1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) Cp162_1842 ENOG4105C6V Glycerol-3-phosphate dehydrogenase Cp162_1851 ENOG4105CJ1 ABC, transporter Cp162_1858 ENOG4105DWV Homoserine O-trans-acetylase Cp162_1862 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) Cp162_1863 ENOG4105C19 ABC transporter Cp162_1864 ENOG4105DJY efflux transporter, rnd family, mfp subunit Cp162_1869 ENOG4105C26 Dehydrogenase Cp162_1872 ENOG4105KNI merR family transcriptional Regulator Cp162_1875 ENOG4105CFG Acts as a chaperone (By similarity) Cp162_1881 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component Cp162_1887 ENOG4105DF6 Fe-S oxidoreductase Cp162_1890 ENOG4105E0A ABC, transporter Cp162_1891 ENOG4108ESU Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Involved in the translocation of the substrate across the membrane (By similarity) Cp162_1893 ENOG4105ICD Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) Cp162_1894 ENOG4107S16 Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG (By similarity) Cp162_1895 ENOG4108YH3 Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) Cp162_1896 ENOG4105HFU Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly (By similarity) Cp162_1897 ENOG4105CQM Urea amidohydrolase subunit alpha Cp162_1898 ENOG4105KI2 Urea amidohydrolase subunit beta Cp162_1899 ENOG4108YZ9 Urea amidohydrolase subunit gamma Cp162_1903 ENOG4105CRK lysyL-tRNA synthetase Cp162_1907 ENOG4105C6Y Udp-glucose 6-dehydrogenase Cp162_1909 ENOG4105C26 Dehydrogenase Cp162_1911 ENOG4107QPA Cleaves GlcNAc linked beta-1,4 to MurNAc tripeptides (By similarity) Cp162_1913 ENOG41073B4 coagulation factor 5 8 type domain-containing protein Cp162_1917 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) Cp162_1926 ENOG4105D8K carboxyl transferase Cp162_1927 ENOG4107EEY synthase Cp162_1928 ENOG4107RCI amp-dependent synthetase and ligase Cp162_1931 ENOG4107YB1 Trehalose corynomycolyl transferase Cp162_1934 ENOG4107ISF Involved in the biosynthesis of the arabinogalactan (AG) region of the mycolylarabinogalactan-peptidoglycan (mAGP) complex, an essential component the mycobacterial cell wall. Catalyzes the transfer of arabinofuranosyl (Araf) residues residue from the sugar donor beta-D-arabinofuranosyl-1-monophosphoryldecaprenol (DPA) to the arabinan domain to form terminal beta-(1- 2)-linked Araf residues, which marks the end point for AG arabinan biosynthesis before decoration with mycolic acids Cp162_1936 ENOG4106YN8 Prenyltransferase Cp162_1938 ENOG410602S Transferase Cp162_1940 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase Cp162_1942 ENOG4108QXE glycerophosphoryl diester phosphodiesterase Cp162_1943 ENOG4105CXY transporter Cp162_1945 ENOG4105E0A ABC, transporter Cp162_1946 ENOG4105EHG Permease protein Cp162_1947 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) Cp162_1950 ENOG4108KP7 hydrolase Cp162_1953 ENOG4105FDP GntR family transcriptional regulator Cp162_1957 ENOG4105CQC Prephenate dehydratase Cp162_1958 ENOG4105DV0 amidase (EC 3.5.1.4 Cp162_1960 ENOG4108KGH TRANSCRIPTIONal Cp162_1963 ENOG4105BZG amino acid carrier protein Cp162_1964 ENOG4105EXC Acyl-transferase Cp162_1967 ENOG4105D9N nucleoside Cp162_1973 ENOG4108YYH Nadph-dependent fmn reductase Cp162_1974 ENOG4105D94 Major Facilitator Superfamily Cp162_1975 ENOG4105CXY transporter Cp162_1977 ENOG4108VJY integral membrane protein Cp162_1981 ENOG4105WH1 Two component transcriptional regulator luxr family Cp162_1985 ENOG4108RN7 integral membrane protein Cp162_1986 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins Cp162_1995 ENOG4105DVE abc transporter atp-binding protein Cp162_1999 ENOG41080RH Thioredoxin Cp162_2002 ENOG41079KZ Major Facilitator Superfamily Cp162_2013 ENOG4105BZ4 penicillin-binding protein Cp162_2017 ENOG4108RKS Short-chain dehydrogenase reductase Sdr Cp162_2021 ENOG4107XFB conserved TRANSMEMBRANE PROTEIN Cp162_2022 ENOG4105DPV During stationary phase, binds the chromosome non- specifically, forming a highly ordered and stable dps-DNA co- crystal within which chromosomal DNA is condensed and protected from diverse damages. It protects DNA from oxidative damage by sequestering intracellular Fe(2 ) ion and storing it in the form of Fe(3 ) oxyhydroxide mineral, which can be released after reduction. One hydrogen peroxide oxidizes two Fe(2 ) ions, which prevents hydroxyl radical production by the Fenton reaction Cp162_2023 ENOG4108S0J Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized pyrimidines, such as thymine glycol, 5,6-dihydrouracil and 5,6-dihydrothymine. Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'- phosphates (By similarity) Cp162_2026 ENOG4105ECB domain protein Cp162_2031 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) Cp162_2034 ENOG4105ENE Histidine kinase Cp162_2035 ENOG4105WH1 Two component transcriptional regulator luxr family Cp162_2038 ENOG4105CE4 GlcNAc 6-P deacetylase Cp162_2041 ENOG4107EJG GntR family transcriptional regulator Cp162_2042 ENOG4105DEF Extracellular solute-binding protein, family 5 Cp162_2043 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component Cp162_2045 ENOG4108JQ7 (ABC) transporter Cp162_2046 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) Cp162_2054 ENOG4106178 UPF0339 protein Cp162_2057 ENOG4107QV7 Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system) (By similarity) Cp162_2059 ENOG4105EWK phytoene Cp162_2061 ENOG4105CRQ synthase (Component I) Cp162_2062 ENOG4105RGK anthranilate synthase component ii Cp162_2064 ENOG4105DK0 Indole-3-glycerol phosphate synthase Cp162_2069 ENOG4105DHU Bile acid Cp162_2071 ENOG4105KMT branched-chain amino acid Cp162_2072 ENOG4108UMN azlc family Cp162_2073 ENOG4108UJU UPF0301 protein Cp162_2074 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate Cp162_2078 ENOG4105EMN RNA polymerase sigma factor Cp162_2080 ENOG4105C3M thioredoxin reductase Cp162_2081 ENOG4105K63 Thioredoxin Cp162_2082 ENOG4108E1C hydrolase Cp162_2085 ENOG4107QJE Chromosome Partitioning Protein Cp162_2089 ENOG41084CH 50S ribosomal protein l34 Cp162_2097 ENOG4105EHG Permease protein Cp162_2108 ENOG4105CI1 PTS System Cp162_2116 ENOG4108IUE nitrate reductase beta subunit Cp162_2129 ENOG4105D3Z quinone oxidoreductase, yhdh yhfp family Cp162_2161 ENOG4105E0A ABC, transporter Cp162_2162 ENOG4108M6P methyltransferase Cp162_2167 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) Cp162_2171 ENOG4107QRT dEAD DEAH box helicase