locus-tag	class	description
Cp162_0002	COG0592	DNA-directed DNA polymerase activity
Cp162_0005	COG0187	DNA topoisomerase II activity
Cp162_0009	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
Cp162_0028	COG1120	ATPase activity
Cp162_0029	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Cp162_0030	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Cp162_0031	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
Cp162_0033	COG2815	serine threonine protein kinase
Cp162_0033	COG0515	serine threonine protein kinase
Cp162_0034	COG0515	serine threonine protein kinase
Cp162_0035	COG0768	penicillin binding
Cp162_0039	COG1716	ATPase activity
Cp162_0039	COG1716	ATPase activity
Cp162_0044	COG2239	Acts as a magnesium transporter
Cp162_0046	COG0366	Alpha amylase catalytic
Cp162_0061	COG0517	IMP dehydrogenase activity
Cp162_0061	COG1125	glycine betaine transport
Cp162_0068	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
Cp162_0076	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
Cp162_0082	COG1846	Transcriptional regulator
Cp162_0087	COG0730	response to heat
Cp162_0090	COG1643	Atp-dependent helicase
Cp162_0091	COG3145	DNA-N1-methyladenine dioxygenase activity
Cp162_0092	COG0519	Catalyzes the synthesis of GMP from XMP
Cp162_0094	COG0393	Putative heavy-metal-binding
Cp162_0095	COG2501	S4 domain
Cp162_0099	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
Cp162_0100	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
Cp162_0102	COG3590	peptidase
Cp162_0108	COG1028	Short-chain dehydrogenase reductase Sdr
Cp162_0109	COG0277	FAD linked oxidase domain protein
Cp162_0115	COG1216	Glycosyl transferase, family 2
Cp162_0116	COG0803	Belongs to the bacterial solute-binding protein 9 family
Cp162_0117	COG1121	(ABC) transporter
Cp162_0118	COG1108	ABC-type Mn2 Zn2 transport systems permease components
Cp162_0119	COG1108	ABC-type Mn2 Zn2 transport systems permease components
Cp162_0120	COG0803	Belongs to the bacterial solute-binding protein 9 family
Cp162_0125	COG0604	alcohol dehydrogenase
Cp162_0129	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
Cp162_0129	COG1263	PTS System
Cp162_0133	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
Cp162_0136	COG0287	Prephenate dehydrogenase
Cp162_0138	COG0590	tRNA wobble adenosine to inosine editing
Cp162_0140	COG2409	Drug exporters of the RND superfamily
Cp162_0141	COG0343	queuine tRNA-ribosyltransferase activity
Cp162_0143	COG2610	gluconate transmembrane transporter activity
Cp162_0144	COG3265	gluconokinase activity
Cp162_0145	COG1063	alcohol dehydrogenase
Cp162_0146	COG1028	Short-chain dehydrogenase reductase Sdr
Cp162_0148	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
Cp162_0153	COG2610	gluconate transmembrane transporter activity
Cp162_0154	COG2084	Dehydrogenase
Cp162_0157	COG0179	Fumarylacetoacetate (FAA) hydrolase
Cp162_0160	COG3442	glutamine amidotransferase
Cp162_0161	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
Cp162_0163	COG0778	Nitroreductase
Cp162_0164	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Cp162_0165	COG2390	Transcriptional regulator
Cp162_0166	COG0813	purine-nucleoside phosphorylase activity
Cp162_0169	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
Cp162_0173	COG0697	spore germination
Cp162_0174	COG0527	aspartate kinase activity
Cp162_0183	COG3842	ATPase activity
Cp162_0185	COG1840	ABC-type Fe3 transport system, periplasmic component
Cp162_0186	COG2271	Major facilitator Superfamily
Cp162_0194	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
Cp162_0194	COG2111	Na H antiporter
Cp162_0199	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
Cp162_0204	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
Cp162_0208	COG0494	nUDIX hydrolase
Cp162_0221	COG1111	helicase
Cp162_0221	COG1205	dead DEAH box helicase
Cp162_0223	COG1754	DNA topoisomerase type I activity
Cp162_0223	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
Cp162_0224	COG1297	OPT oligopeptide transporter protein
Cp162_0226	COG0470	DNA polymerase III
Cp162_0228	COG0318	PFAM AMP-dependent synthetase and ligase
Cp162_0230	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
Cp162_0232	COG1088	dTDP-glucose 4,6-dehydratase activity
Cp162_0234	COG1505	serine-type exopeptidase activity
Cp162_0237	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
Cp162_0238	COG1396	sequence-specific DNA binding
Cp162_0238	COG3800	Transcriptional regulator
Cp162_0240	COG1053	succinate dehydrogenase
Cp162_0241	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
Cp162_0243	COG2733	membrane
Cp162_0245	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
Cp162_0249	COG1882	Formate acetyltransferase
Cp162_0253	COG0318	PFAM AMP-dependent synthetase and ligase
Cp162_0257	COG0745	RESPONSE REGULATOR receiver
Cp162_0262	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
Cp162_0266	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
Cp162_0266	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
Cp162_0268	COG0560	Phosphoserine phosphatase
Cp162_0272	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
Cp162_0272	COG1648	precorrin-2 dehydrogenase activity
Cp162_0275	COG2217	Heavy metal translocating P-type atpase
Cp162_0280	COG0406	alpha-ribazole phosphatase activity
Cp162_0282	COG0785	Cytochrome C biogenesis protein
Cp162_0284	COG0275	rRNA processing
Cp162_0287	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Cp162_0288	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
Cp162_0295	COG4948	Mandelate Racemase Muconate Lactonizing
Cp162_0300	COG0039	L-malate dehydrogenase activity
Cp162_0301	COG0644	oxidoreductase
Cp162_0303	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
Cp162_0308	COG3579	cysteine-type endopeptidase activity
Cp162_0309	COG1902	pentaerythritol trinitrate reductase activity
Cp162_0313	COG0803	Belongs to the bacterial solute-binding protein 9 family
Cp162_0315	COG1121	(ABC) transporter
Cp162_0316	COG1108	ABC-type Mn2 Zn2 transport systems permease components
Cp162_0322	COG2197	response regulator
Cp162_0324	COG1131	(ABC) transporter
Cp162_0327	COG0701	Predicted permease
Cp162_0341	COG1302	Protein conserved in bacteria
Cp162_0342	COG0051	transcription antitermination factor activity, RNA binding
Cp162_0362	COG0814	amino acid
Cp162_0363	COG1760	l-serine dehydratase
Cp162_0365	COG0252	asparaginase activity
Cp162_0367	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
Cp162_0377	COG1175	transmembrane transport
Cp162_0378	COG3833	ABC-type maltose transport systems, permease component
Cp162_0382	COG3842	ATPase activity
Cp162_0383	COG0201	protein transport
Cp162_0393	COG0203	ribosomal protein L17
Cp162_0397	COG1404	Belongs to the peptidase S8 family
Cp162_0399	COG1674	ftsk spoiiie
Cp162_0411	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
Cp162_0425	COG0516	GMP reductase activity
Cp162_0434	COG2011	ABC-type metal ion transport system permease component
Cp162_0436	COG1464	Belongs to the NlpA lipoprotein family
Cp162_0437	COG1464	Belongs to the NlpA lipoprotein family
Cp162_0440	COG0803	Belongs to the bacterial solute-binding protein 9 family
Cp162_0441	COG1121	(ABC) transporter
Cp162_0443	COG1321	iron dependent repressor
Cp162_0443	COG1108	ABC-type Mn2 Zn2 transport systems permease components
Cp162_0444	COG1321	iron dependent repressor
Cp162_0445	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
Cp162_0446	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
Cp162_0454	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
Cp162_0456	COG2873	o-acetylhomoserine
Cp162_0457	COG2838	Isocitrate dehydrogenase
Cp162_0458	COG2814	Major facilitator Superfamily
Cp162_0462	COG0180	Tryptophanyl-tRNA synthetase
Cp162_0463	COG1295	ribonuclease BN
Cp162_0464	COG1686	Belongs to the peptidase S11 family
Cp162_0471	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
Cp162_0472	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
Cp162_0472	COG1473	amidohydrolase
Cp162_0474	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
Cp162_0475	COG2814	Major facilitator Superfamily
Cp162_0477	COG4770	biotin carboxylase activity
Cp162_0478	COG2897	thiosulfate sulfurtransferase activity
Cp162_0480	COG0189	ligase activity
Cp162_0481	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
Cp162_0481	COG2755	lipolytic protein G-D-S-L family
Cp162_0483	COG0424	maF-like protein
Cp162_0484	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
Cp162_0485	COG1609	Transcriptional regulator
Cp162_0487	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
Cp162_0488	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
Cp162_0490	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
Cp162_0490	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
Cp162_0501	COG1316	TRANSCRIPTIONal
Cp162_0503	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
Cp162_0509	COG1482	cell wall glycoprotein biosynthetic process
Cp162_0516	COG0745	RESPONSE REGULATOR receiver
Cp162_0517	COG5002	protein histidine kinase activity
Cp162_0520	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
Cp162_0528	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
Cp162_0529	COG2135	peptidase activity
Cp162_0530	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
Cp162_0537	COG0513	Belongs to the DEAD box helicase family
Cp162_0544	COG2816	NAD+ diphosphatase activity
Cp162_0549	COG3480	Lon protease (S16) C-terminal proteolytic domain
Cp162_0570	COG0483	inositol monophosphate 1-phosphatase activity
Cp162_0571	COG0483	inositol monophosphate 1-phosphatase activity
Cp162_0574	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
Cp162_0575	COG2884	Cell division ATP-binding protein ftsE
Cp162_0576	COG2177	Part of the ABC transporter FtsEX involved in
Cp162_0579	COG0288	reversible hydration of carbon dioxide
Cp162_0591	COG1652	LysM domain
Cp162_0597	COG2252	PERMEase
Cp162_0598	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
Cp162_0603	COG0372	Belongs to the citrate synthase family
Cp162_0604	COG0545	Peptidyl-prolyl cis-trans isomerase
Cp162_0609	COG0656	L-ascorbic acid biosynthetic process
Cp162_0610	COG1024	Enoyl-CoA hydratase
Cp162_0612	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
Cp162_0614	COG3757	hydrolase, family 25
Cp162_0617	COG0534	Mate efflux family protein
Cp162_0618	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
Cp162_0619	COG0019	diaminopimelate decarboxylase activity
Cp162_0622	COG4166	transmembrane transport
Cp162_0631	COG1218	3'(2'),5'-bisphosphate nucleotidase
Cp162_0633	COG1201	RNA secondary structure unwinding
Cp162_0635	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
Cp162_0641	COG0739	heme binding
Cp162_0645	COG1126	abc transporter atp-binding protein
Cp162_0646	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Cp162_0647	COG0765	amino acid transport
Cp162_0648	COG0765	amino acid transport
Cp162_0656	COG0254	rRNA binding
Cp162_0658	COG0745	RESPONSE REGULATOR receiver
Cp162_0659	COG2205	protein histidine kinase activity
Cp162_0660	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Cp162_0661	COG0315	cyclic pyranopterin monophosphate synthase activity
Cp162_0661	COG0521	Mo-molybdopterin cofactor biosynthetic process
Cp162_0665	COG1210	Utp--glucose-1-phosphate uridylyltransferase
Cp162_0669	COG2259	Doxx family
Cp162_0671	COG1928	C-terminal four TMM region of protein-O-mannosyltransferase
Cp162_0672	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
Cp162_0673	COG3949	Membrane
Cp162_0676	COG0084	hydrolase, TatD family'
Cp162_0677	COG3583	domain protein
Cp162_0680	COG0488	(ABC) transporter
Cp162_0683	COG2326	polyphosphate kinase activity
Cp162_0685	COG0561	phosphatase activity
Cp162_0694	COG0596	Alpha beta hydrolase
Cp162_0695	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
Cp162_0697	COG0193	aminoacyl-tRNA hydrolase activity
Cp162_0698	COG2070	2-Nitropropane dioxygenase
Cp162_0702	COG1523	belongs to the glycosyl hydrolase 13 family
Cp162_0703	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
Cp162_0704	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
Cp162_0705	COG2132	Multicopper oxidase
Cp162_0707	COG1309	transcriptional regulator
Cp162_0709	COG0531	amino acid
Cp162_0710	COG3956	TIGRFAM MazG family protein
Cp162_0722	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
Cp162_0736	COG0114	fumarate hydratase activity
Cp162_0737	COG1494	fructose-1,6-bisphosphatase
Cp162_0744	COG0012	GTP binding
Cp162_0746	COG2824	Alkylphosphonate utilization operon protein PhnA
Cp162_0747	COG1132	(ABC) transporter
Cp162_0748	COG1132	(ABC) transporter
Cp162_0750	COG2354	Protein conserved in bacteria
Cp162_0752	COG4721	ABC-type cobalt transport system, permease component
Cp162_0753	COG1122	ATPase activity
Cp162_0757	COG4166	transmembrane transport
Cp162_0758	COG0601	transmembrane transport
Cp162_0761	COG5640	endopeptidase activity
Cp162_0767	COG4166	transmembrane transport
Cp162_0774	COG1113	amino acid transport
Cp162_0776	COG1113	amino acid transport
Cp162_0778	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
Cp162_0779	COG1611	Belongs to the LOG family
Cp162_0780	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
Cp162_0781	COG0463	Glycosyl transferase, family 2
Cp162_0786	COG3527	Alpha-acetolactate decarboxylase
Cp162_0787	COG0297	glycogen (starch) synthase activity
Cp162_0789	COG4122	O-methyltransferase activity
Cp162_0795	COG2239	Acts as a magnesium transporter
Cp162_0797	COG0567	Dehydrogenase, E1 component
Cp162_0797	COG0508	dehydrogenase complex catalyzes the overall conversion of
Cp162_0798	COG1132	(ABC) transporter
Cp162_0800	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
Cp162_0801	COG2272	Belongs to the type-B carboxylesterase lipase family
Cp162_0805	COG2017	converts alpha-aldose to the beta-anomer
Cp162_0809	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
Cp162_0815	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
Cp162_0816	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
Cp162_0821	COG1846	Transcriptional regulator
Cp162_0824	COG1349	DNA-binding transcription factor activity
Cp162_0826	COG1556	Lactate utilization protein
Cp162_0827	COG1139	Iron-sulfur cluster binding protein
Cp162_0828	COG0247	lactate metabolic process
Cp162_0829	COG1620	l-lactate permease
Cp162_0831	COG0019	diaminopimelate decarboxylase activity
Cp162_0832	COG0460	homoserine dehydrogenase
Cp162_0843	COG0356	it plays a direct role in the translocation of protons across the membrane
Cp162_0844	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
Cp162_0845	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
Cp162_0858	COG1119	ATPase activity
Cp162_0862	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
Cp162_0875	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Cp162_0876	COG1120	ATPase activity
Cp162_0878	COG0205	6-phosphofructokinase activity
Cp162_0880	COG0667	Aldo Keto reductase
Cp162_0882	COG0583	DNA-binding transcription factor activity
Cp162_0887	COG0668	transmembrane transport
Cp162_0895	COG0473	3-isopropylmalate dehydrogenase activity
Cp162_0899	COG0179	Fumarylacetoacetate (FAA) hydrolase
Cp162_0913	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
Cp162_0914	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
Cp162_0915	COG1461	Dihydroxyacetone kinase
Cp162_0917	COG0511	ligase activity, forming carbon-carbon bonds
Cp162_0918	COG0742	ribosomal rna small subunit methyltransferase
Cp162_0923	COG0765	amino acid transport
Cp162_0927	COG2226	methyltransferase
Cp162_0929	COG0539	negative regulation of cytoplasmic translation
Cp162_0932	COG0237	dephospho-CoA kinase activity
Cp162_0936	COG3973	AAA domain
Cp162_0941	COG0291	Belongs to the bacterial ribosomal protein bL35 family
Cp162_0944	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
Cp162_0947	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
Cp162_0950	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
Cp162_0954	COG0165	Argininosuccinate lyase
Cp162_0955	COG2835	tetraacyldisaccharide 4'-kinase activity
Cp162_0959	COG0647	UMP catabolic process
Cp162_0967	COG4974	Belongs to the 'phage' integrase family
Cp162_0971	COG3104	oligopeptide transport
Cp162_0972	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
Cp162_0974	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
Cp162_0977	COG1160	GTP binding
Cp162_0978	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
Cp162_0980	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
Cp162_0981	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
Cp162_0982	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
Cp162_0983	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Cp162_0984	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Cp162_0985	COG1120	ATPase activity
Cp162_0986	COG4264	IucA IucC family
Cp162_0988	COG3012	SEC-C Motif Domain Protein
Cp162_0991	COG0653	protein targeting
Cp162_0999	COG1253	flavin adenine dinucleotide binding
Cp162_1000	COG0513	Belongs to the DEAD box helicase family
Cp162_1001	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
Cp162_1003	COG0598	Magnesium transport protein CorA
Cp162_1008	COG0477	Major facilitator Superfamily
Cp162_1013	COG0463	Glycosyl transferase, family 2
Cp162_1024	COG0300	oxidoreductase activity
Cp162_1027	COG0805	protein transport
Cp162_1029	COG2378	regulation of single-species biofilm formation
Cp162_1033	COG4122	O-methyltransferase activity
Cp162_1036	COG1362	aminopeptidase activity
Cp162_1041	COG1027	Aspartate ammonia-lyase
Cp162_1042	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
Cp162_1046	COG1410	methionine synthase
Cp162_1046	COG0646	methionine synthase
Cp162_1050	COG0667	Aldo Keto reductase
Cp162_1052	COG0167	dihydroorotate dehydrogenase activity
Cp162_1057	COG1461	Dihydroxyacetone kinase
Cp162_1058	COG2376	Dihydroxyacetone kinase
Cp162_1072	COG0791	NLP P60 protein
Cp162_1072	COG3883	PFAM NLP P60 protein
Cp162_1078	COG2848	UPF0210 protein
Cp162_1083	COG2151	metal-sulfur cluster biosynthetic enzyme
Cp162_1084	COG0822	iron-sulfur transferase activity
Cp162_1086	COG0396	ATPase activity
Cp162_1095	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
Cp162_1096	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
Cp162_1100	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
Cp162_1104	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
Cp162_1106	COG0391	Required for morphogenesis under gluconeogenic growth conditions
Cp162_1108	COG0322	excinuclease ABC activity
Cp162_1114	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
Cp162_1117	COG0242	peptide deformylase activity
Cp162_1126	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
Cp162_1128	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
Cp162_1131	COG1090	epimerase
Cp162_1136	COG0006	proline dipeptidase activity
Cp162_1137	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
Cp162_1138	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
Cp162_1139	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
Cp162_1140	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
Cp162_1143	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
Cp162_1144	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
Cp162_1155	COG1760	l-serine dehydratase
Cp162_1160	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Cp162_1161	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
Cp162_1164	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
Cp162_1167	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
Cp162_1168	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
Cp162_1178	COG0156	8-amino-7-oxononanoate synthase activity
Cp162_1181	COG1560	Kdo2-lipid A biosynthetic process
Cp162_1185	COG2837	iron assimilation
Cp162_1191	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
Cp162_1209	COG2890	protein-(glutamine-N5) methyltransferase activity
Cp162_1217	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
Cp162_1218	COG0450	alkyl hydroperoxide reductase
Cp162_1222	COG1643	Atp-dependent helicase
Cp162_1227	COG1349	DNA-binding transcription factor activity
Cp162_1228	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
Cp162_1229	COG1349	DNA-binding transcription factor activity
Cp162_1230	COG1105	Belongs to the carbohydrate kinase PfkB family
Cp162_1231	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
Cp162_1231	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
Cp162_1231	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
Cp162_1233	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
Cp162_1234	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
Cp162_1236	COG2233	PERMEase
Cp162_1237	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
Cp162_1240	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
Cp162_1243	COG1196	nuclear chromosome segregation
Cp162_1247	COG2137	regulation of response to DNA damage stimulus
Cp162_1248	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
Cp162_1250	COG1268	BioY protein
Cp162_1251	COG1122	ATPase activity
Cp162_1254	COG1396	sequence-specific DNA binding
Cp162_1258	COG0861	Integral membrane protein TerC family
Cp162_1260	COG1674	ftsk spoiiie
Cp162_1262	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
Cp162_1270	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
Cp162_1273	COG0534	Mate efflux family protein
Cp162_1282	COG3022	response to hydroperoxide
Cp162_1283	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
Cp162_1283	COG1648	precorrin-2 dehydrogenase activity
Cp162_1285	COG0523	cobalamin synthesis protein
Cp162_1286	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
Cp162_1286	COG2169	Transcriptional regulator
Cp162_1299	COG0750	zinc metalloprotease
Cp162_1311	COG4974	Belongs to the 'phage' integrase family
Cp162_1316	COG0681	Belongs to the peptidase S26 family
Cp162_1319	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
Cp162_1319	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
Cp162_1319	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
Cp162_1321	COG0336	Belongs to the RNA methyltransferase TrmD family
Cp162_1322	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
Cp162_1326	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
Cp162_1331	COG1254	Belongs to the acylphosphatase family
Cp162_1332	COG1115	amino acid carrier protein
Cp162_1333	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
Cp162_1338	COG0686	Belongs to the AlaDH PNT family
Cp162_1339	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
Cp162_1340	COG1929	Belongs to the glycerate kinase type-1 family
Cp162_1343	COG1473	amidohydrolase
Cp162_1344	COG0058	SHG alpha-glucan phosphorylase activity
Cp162_1346	COG0469	pyruvate kinase activity
Cp162_1348	COG0134	indole-3-glycerol-phosphate synthase activity
Cp162_1352	COG0483	inositol monophosphate 1-phosphatase activity
Cp162_1365	COG2176	DNA-directed DNA polymerase activity
Cp162_1371	COG1739	Uncharacterized protein family UPF0029
Cp162_1372	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
Cp162_1377	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
Cp162_1380	COG0252	asparaginase activity
Cp162_1384	COG3599	regulation of cell shape
Cp162_1386	COG1799	cell septum assembly
Cp162_1388	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
Cp162_1390	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
Cp162_1397	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
Cp162_1398	COG0768	penicillin binding
Cp162_1411	COG2815	serine threonine protein kinase
Cp162_1411	COG0515	serine threonine protein kinase
Cp162_1412	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
Cp162_1416	COG1940	carbohydrate kinase activity
Cp162_1417	COG0438	transferase activity, transferring glycosyl groups
Cp162_1419	COG0791	NLP P60 protein
Cp162_1430	COG2087	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate
Cp162_1431	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
Cp162_1433	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
Cp162_1436	COG0508	dehydrogenase complex catalyzes the overall conversion of
Cp162_1437	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
Cp162_1437	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
Cp162_1438	COG0404	The glycine cleavage system catalyzes the degradation of glycine
Cp162_1439	COG0509	glycine decarboxylation via glycine cleavage system
Cp162_1445	COG0174	glutamine synthetase
Cp162_1451	COG2056	Na+-H+ antiporter family
Cp162_1454	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
Cp162_1460	COG0174	glutamine synthetase
Cp162_1465	COG0557	exoribonuclease II activity
Cp162_1466	COG0406	alpha-ribazole phosphatase activity
Cp162_1466	COG0328	RNA-DNA hybrid ribonuclease activity
Cp162_1468	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
Cp162_1468	COG3323	Protein of unknown function (DUF1653)
Cp162_1476	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
Cp162_1482	COG2860	membrane
Cp162_1494	COG0423	glycine-tRNA ligase activity
Cp162_1499	COG1381	Involved in DNA repair and RecF pathway recombination
Cp162_1510	COG1022	Amp-dependent synthetase and ligase
Cp162_1520	COG1132	(ABC) transporter
Cp162_1521	COG1114	Component of the transport system for branched-chain amino acids
Cp162_1522	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
Cp162_1524	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
Cp162_1527	COG0747	negative chemotaxis
Cp162_1528	COG0601	transmembrane transport
Cp162_1529	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
Cp162_1530	COG4172	Belongs to the ABC transporter superfamily
Cp162_1533	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
Cp162_1534	COG2391	methyltransferase activity
Cp162_1538	COG4171	peptide transport system, permease
Cp162_1541	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
Cp162_1542	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
Cp162_1546	COG1280	lysine exporter protein (LysE YggA)
Cp162_1551	COG1555	photosystem II stabilization
Cp162_1551	COG1596	polysaccharide export
Cp162_1552	COG1307	EDD domain protein, DegV family
Cp162_1553	COG0406	alpha-ribazole phosphatase activity
Cp162_1555	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
Cp162_1558	COG2832	Protein of unknown function (DUF454)
Cp162_1559	COG0569	domain protein
Cp162_1559	COG2985	domain, Protein
Cp162_1564	COG1530	ribonuclease E activity
Cp162_1567	COG2423	ornithine cyclodeaminase activity
Cp162_1569	COG0285	dihydrofolate synthase activity
Cp162_1577	COG0544	peptidyl-prolyl cis-trans isomerase activity
Cp162_1583	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
Cp162_1588	COG0668	transmembrane transport
Cp162_1605	COG1131	(ABC) transporter
Cp162_1606	COG3336	cytochrome c oxidase
Cp162_1607	COG1966	Carbon starvation protein
Cp162_1609	COG4221	oxidoreductase activity
Cp162_1612	COG1376	ErfK ybiS ycfS ynhG family protein
Cp162_1614	COG2130	NADP-dependent
Cp162_1615	COG1335	isochorismatase
Cp162_1624	COG2197	response regulator
Cp162_1633	COG1234	tRNA 3'-trailer cleavage
Cp162_1638	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
Cp162_1642	COG1518	maintenance of DNA repeat elements
Cp162_1650	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
Cp162_1652	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
Cp162_1656	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
Cp162_1660	COG2217	Heavy metal translocating P-type atpase
Cp162_1666	COG0033	Phosphoglucomutase
Cp162_1669	COG1136	(ABC) transporter
Cp162_1669	COG0577	efflux transmembrane transporter activity
Cp162_1670	COG1136	(ABC) transporter
Cp162_1670	COG0577	efflux transmembrane transporter activity
Cp162_1675	COG2197	response regulator
Cp162_1677	COG1045	serine acetyltransferase
Cp162_1679	COG0371	Dehydrogenase
Cp162_1680	COG1271	oxidase subunit
Cp162_1681	COG1294	oxidase, subunit
Cp162_1682	COG4988	ABC transporter
Cp162_1683	COG4988	ABC transporter
Cp162_1688	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
Cp162_1694	COG1597	lipid kinase activity
Cp162_1697	COG0354	folic acid binding
Cp162_1702	COG1780	Probably involved in ribonucleotide reductase function
Cp162_1703	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
Cp162_1705	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
Cp162_1706	COG0047	phosphoribosylformylglycinamidine synthase activity
Cp162_1707	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
Cp162_1708	COG0386	Belongs to the glutathione peroxidase family
Cp162_1712	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
Cp162_1713	COG0569	domain protein
Cp162_1714	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
Cp162_1715	COG0151	Belongs to the GarS family
Cp162_1716	COG0537	adenosine 5'-monophosphoramidase activity
Cp162_1718	COG2205	protein histidine kinase activity
Cp162_1719	COG0745	RESPONSE REGULATOR receiver
Cp162_1720	COG0477	Major facilitator Superfamily
Cp162_1725	COG0028	Belongs to the TPP enzyme family
Cp162_1733	COG1609	Transcriptional regulator
Cp162_1734	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
Cp162_1738	COG1329	Transcriptional regulator
Cp162_1740	COG2847	Copper chaperone PCu(A)C
Cp162_1742	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
Cp162_1744	COG0288	reversible hydration of carbon dioxide
Cp162_1748	COG0542	response to heat
Cp162_1750	COG0477	Major facilitator Superfamily
Cp162_1751	COG1957	nucleoside hydrolase
Cp162_1754	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
Cp162_1757	COG1301	dicarboxylic acid transport
Cp162_1759	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
Cp162_1760	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
Cp162_1761	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
Cp162_1767	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
Cp162_1768	COG0302	gtp cyclohydrolase
Cp162_1769	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
Cp162_1773	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
Cp162_1774	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
Cp162_1774	COG0425	Belongs to the sulfur carrier protein TusA family
Cp162_1775	COG1301	dicarboxylic acid transport
Cp162_1779	COG2326	polyphosphate kinase activity
Cp162_1784	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
Cp162_1794	COG1051	belongs to the nudix hydrolase family
Cp162_1798	COG0242	peptide deformylase activity
Cp162_1799	COG0456	acetyltransferase
Cp162_1800	COG0708	Exodeoxyribonuclease III
Cp162_1801	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
Cp162_1806	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Cp162_1809	COG0280	phosphate acetyltransferase
Cp162_1812	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
Cp162_1813	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
Cp162_1820	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
Cp162_1821	COG1333	cytochrome c biogenesis protein
Cp162_1823	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
Cp162_1824	COG3005	denitrification pathway
Cp162_1827	COG4129	membrane
Cp162_1829	COG4129	membrane
Cp162_1836	COG0191	fructose-bisphosphate aldolase activity
Cp162_1839	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
Cp162_1842	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
Cp162_1851	COG1131	(ABC) transporter
Cp162_1858	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
Cp162_1862	COG1136	(ABC) transporter
Cp162_1862	COG0577	efflux transmembrane transporter activity
Cp162_1863	COG1136	(ABC) transporter
Cp162_1864	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Cp162_1869	COG1012	belongs to the aldehyde dehydrogenase family
Cp162_1872	COG0789	Transcriptional regulator
Cp162_1875	COG0443	Heat shock 70 kDa protein
Cp162_1881	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
Cp162_1882	COG0601	transmembrane transport
Cp162_1887	COG2181	nitrate reductase activity
Cp162_1887	COG0247	lactate metabolic process
Cp162_1890	COG1120	ATPase activity
Cp162_1891	COG4139	cobalamin transport
Cp162_1893	COG0829	nickel cation binding
Cp162_1894	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
Cp162_1895	COG0830	nickel cation binding
Cp162_1896	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
Cp162_1897	COG0804	urea catabolic process
Cp162_1898	COG0832	Belongs to the urease beta subunit family
Cp162_1899	COG0831	urea catabolic process
Cp162_1903	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
Cp162_1903	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
Cp162_1907	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
Cp162_1909	COG1012	belongs to the aldehyde dehydrogenase family
Cp162_1911	COG1472	Belongs to the glycosyl hydrolase 3 family
Cp162_1913	COG4981	capsule polysaccharide biosynthetic process
Cp162_1917	COG0438	transferase activity, transferring glycosyl groups
Cp162_1926	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
Cp162_1927	COG3321	synthase
Cp162_1927	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
Cp162_1928	COG0318	PFAM AMP-dependent synthetase and ligase
Cp162_1931	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
Cp162_1931	COG5479	isomerase activity
Cp162_1934	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
Cp162_1936	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
Cp162_1937	COG0671	phosphoesterase, PA-phosphatase related
Cp162_1938	COG1216	Glycosyl transferase, family 2
Cp162_1940	COG0671	phosphoesterase, PA-phosphatase related
Cp162_1942	COG0584	glycerophosphoryl diester phosphodiesterase
Cp162_1943	COG2271	Major facilitator Superfamily
Cp162_1945	COG1120	ATPase activity
Cp162_1946	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Cp162_1947	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
Cp162_1950	COG0561	phosphatase activity
Cp162_1953	COG2188	Transcriptional regulator
Cp162_1957	COG0077	Prephenate dehydratase
Cp162_1958	COG0154	amidase activity
Cp162_1960	COG1316	TRANSCRIPTIONal
Cp162_1963	COG1115	amino acid carrier protein
Cp162_1967	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
Cp162_1973	COG0431	NADPH-dependent FMN reductase
Cp162_1974	COG2814	Major facilitator Superfamily
Cp162_1975	COG2271	Major facilitator Superfamily
Cp162_1977	COG5650	phosphatidylinositol metabolic process
Cp162_1981	COG2197	response regulator
Cp162_1985	COG3764	Sortase (surface protein transpeptidase)
Cp162_1986	COG0706	membrane insertase activity
Cp162_1992	COG0564	pseudouridine synthase activity
Cp162_1995	COG1131	(ABC) transporter
Cp162_1999	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
Cp162_2002	COG0477	Major facilitator Superfamily
Cp162_2003	COG0305	Participates in initiation and elongation during chromosome replication
Cp162_2013	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
Cp162_2017	COG0300	oxidoreductase activity
Cp162_2021	COG0586	Pfam SNARE associated Golgi protein
Cp162_2022	COG0783	Belongs to the Dps family
Cp162_2023	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
Cp162_2024	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
Cp162_2024	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
Cp162_2026	COG1511	domain protein
Cp162_2031	COG1136	(ABC) transporter
Cp162_2031	COG0577	efflux transmembrane transporter activity
Cp162_2034	COG4585	Histidine kinase
Cp162_2035	COG2197	response regulator
Cp162_2038	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
Cp162_2041	COG2186	Transcriptional regulator
Cp162_2042	COG0747	negative chemotaxis
Cp162_2043	COG0601	transmembrane transport
Cp162_2044	COG0444	Belongs to the ABC transporter superfamily
Cp162_2045	COG4608	Belongs to the ABC transporter superfamily
Cp162_2046	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
Cp162_2054	COG3422	double-strand break repair
Cp162_2057	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
Cp162_2061	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
Cp162_2062	COG0512	Glutamine amidotransferase of anthranilate synthase
Cp162_2064	COG0135	phosphoribosylanthranilate isomerase activity
Cp162_2064	COG0134	indole-3-glycerol-phosphate synthase activity
Cp162_2071	COG1687	branched-chain amino acid
Cp162_2072	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
Cp162_2073	COG1678	Uncharacterized ACR, COG1678
Cp162_2074	COG0617	tRNA 3'-terminal CCA addition
Cp162_2082	COG3409	Peptidoglycan-binding domain 1 protein
Cp162_2082	COG0860	N-Acetylmuramoyl-L-alanine amidase
Cp162_2085	COG1192	Involved in chromosome partitioning
Cp162_2089	COG0230	Belongs to the bacterial ribosomal protein bL34 family
Cp162_2097	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Cp162_2108	COG1263	PTS System
Cp162_2108	COG2190	(PTS) system
Cp162_2108	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
Cp162_2116	COG1140	nitrate reductase beta subunit
Cp162_2129	COG0604	alcohol dehydrogenase
Cp162_2161	COG1120	ATPase activity
Cp162_2162	COG0500	methyltransferase
Cp162_2167	COG0315	cyclic pyranopterin monophosphate synthase activity
Cp162_2171	COG1201	RNA secondary structure unwinding