locus-tag class description CpMB16_00015 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) CpMB16_00030 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) CpMB16_00050 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) CpMB16_00095 ENOG4107SDZ Galactoside transport system permease protein mglC CpMB16_00100 ENOG4105C2J ABC transporter CpMB16_00135 ENOG4105TZK CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. May be involved in the integration of spacer DNA into the CRISPR cassette (By similarity) CpMB16_00180 ENOG4105E0A ABC, transporter CpMB16_00185 ENOG4105TVJ transport system, permease CpMB16_00190 ENOG4105DQ5 transport system permease protein CpMB16_00195 ENOG4108MES Periplasmic binding protein CpMB16_00200 ENOG4105XBB septation inhibitor protein CpMB16_00205 ENOG4108DT4 serine threonine protein kinase CpMB16_00215 ENOG4105CJN penicillin-binding protein CpMB16_00220 ENOG4107QHZ cell cycle protein CpMB16_00235 ENOG4105TV9 FHA Domain-Containing protein CpMB16_00235 ENOG4105TV9 FHA Domain-Containing protein CpMB16_00285 ENOG4105CJW magnesium transporter CpMB16_00290 ENOG4105CG3 alpha amylase, catalytic region CpMB16_00315 ENOG4105K6V RNA polymerase CpMB16_00345 ENOG4108IJ8 ABC transporter CpMB16_00360 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) CpMB16_00370 ENOG41066NP positive regulation by symbiont of host immune response CpMB16_00380 ENOG4105FYV Amp nucleosidase CpMB16_00390 ENOG4107YXZ hydrolase, family 25 CpMB16_00415 ENOG4108Z0R Transferase CpMB16_00430 ENOG4108URH decarboxylase CpMB16_00440 ENOG4105K56 Transcriptional regulator CpMB16_00455 ENOG4108KK1 membrane protein AbrB duplication CpMB16_00465 ENOG4105EJ9 Membrane CpMB16_00470 ENOG4106ETB IIa component CpMB16_00480 ENOG4105CQ7 ATP-dependent helicase CpMB16_00485 ENOG4105CF1 Alkylated DNA repair protein CpMB16_00490 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) CpMB16_00500 ENOG4105K8R UPF0145 protein CpMB16_00505 ENOG410848D S4 domain protein YaaA CpMB16_00530 ENOG4108JQ0 Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) CpMB16_00535 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) CpMB16_00545 ENOG4105C9K Endothelin-converting enzyme 1 CpMB16_00565 ENOG4105J1Z Arabinosyltransferase CpMB16_00570 ENOG4108K7T Involved in the biosynthesis of the arabinogalactan (AG) region of the mycolylarabinogalactan-peptidoglycan (mAGP) complex, an essential component the mycobacterial cell wall. Catalyzes the addition of the first key arabinofuranosyl (Araf) residue from the sugar donor beta-D-arabinofuranosyl-1-monophosphoryldecaprenol (DPA) on the C-5 of a 6-linked galactofuranosyl (Galf) of the galactan domain, thus 'priming' the galactan for further elaboration by other arabinofuranosyltransferases CpMB16_00575 ENOG4108RG3 short-chain dehydrogenase reductase CpMB16_00580 ENOG4105IQ5 FAD linked oxidase domain protein CpMB16_00610 ENOG4108MKI Glycosyl transferase, family 2 CpMB16_00615 ENOG4107SIG periplasmic solute binding protein CpMB16_00620 ENOG4105DIK (ABC) transporter CpMB16_00625 ENOG4107RPQ ABC transporter CpMB16_00630 ENOG4107RBD ABC, transporter CpMB16_00635 ENOG4105DSE periplasmic solute binding protein CpMB16_00660 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein CpMB16_00720 ENOG4105C8P )-transporter CpMB16_00735 ENOG4105CI1 PTS System CpMB16_00745 ENOG4105DSQ Nitric oxide reductase CpMB16_00760 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family CpMB16_00775 ENOG4105EVN Prephenate dehydrogenase CpMB16_00785 ENOG4108Z6B deaminase CpMB16_00795 ENOG4105EYF MMPL domain protein CpMB16_00800 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) CpMB16_00810 ENOG4105C6Z Gluconate CpMB16_00815 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family CpMB16_00820 ENOG4105CPQ Dehydrogenase CpMB16_00825 ENOG4105CHR reductase CpMB16_00840 ENOG4105XT2 Transcriptional regulator CpMB16_00865 ENOG4105C6Z Gluconate CpMB16_00870 ENOG4105ZXK Dehydrogenase CpMB16_00880 ENOG4107U9B transcriptional regulator CpMB16_00885 ENOG4105ERH Fumarylacetoacetate hydrolase CpMB16_00895 ENOG4105F1K Glutamine amidotransferase CpMB16_00900 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) CpMB16_00910 ENOG4108DBC nitroreductase CpMB16_00920 ENOG4107RHR regulatoR CpMB16_00925 ENOG4105D3A purine nucleoside phosphorylase DeoD-type CpMB16_00940 ENOG4107QSU Phosphoglucomutase phosphomannomutase alpha beta alpha domain CpMB16_00950 ENOG4105DUY Ser-Asp rich fibrinogen-binding, bone sialoprotein-binding protein CpMB16_00960 ENOG4105PP6 Membrane CpMB16_00965 ENOG4105CFH Aspartokinase CpMB16_00985 ENOG4105CH6 catalase CpMB16_01005 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) CpMB16_01015 ENOG4107QKW extracellular solute-binding protein family 1 CpMB16_01020 ENOG4105CXY transporter CpMB16_01025 ENOG4105CK6 Two component transcriptional regulator (Winged helix family CpMB16_01050 ENOG4108JPZ Monovalent cation H antiporter subunit D CpMB16_01060 ENOG4105D65 subunit l CpMB16_01070 ENOG4108NJC CpMB16_01090 ENOG4105BZ4 penicillin-binding protein CpMB16_01095 ENOG4105N0U Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) CpMB16_01115 ENOG4105IJJ transcriptional regulator, crp fnr family CpMB16_01135 ENOG4105P8F nudix hydrolase CpMB16_01205 ENOG4108I5C dEAD DEAH box helicase CpMB16_01215 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) CpMB16_01220 ENOG4105EPD Oligopeptide transporter, Opt family CpMB16_01230 ENOG4107QRG dna polymerase iii CpMB16_01245 ENOG4105CEY Amp-dependent synthetase and ligase CpMB16_01255 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) CpMB16_01265 ENOG4105C1B dTDP-glucose 4-6-dehydratase CpMB16_01290 ENOG4107QN2 dihydrolipoyl dehydrogenase CpMB16_01295 ENOG4105CFF transcriptional regulator CpMB16_01310 ENOG4105E33 succinate dehydrogenase CpMB16_01320 ENOG4106BRA Membrane CpMB16_01330 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) CpMB16_01350 ENOG4105C6N Formate acetyltransferase CpMB16_01370 ENOG4105CEY Amp-dependent synthetase and ligase CpMB16_01385 ENOG4105BZU Histidine kinase CpMB16_01390 ENOG4105CK6 Two component transcriptional regulator (Winged helix family CpMB16_01410 ENOG4105II7 pyrroline-5-carboxylate reductase CpMB16_01430 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) CpMB16_01440 ENOG4108RXW HAD-superfamily subfamily IB hydrolase CpMB16_01460 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) CpMB16_01475 ENOG4105C59 p-type ATPase CpMB16_01485 ENOG4105C1Q protoporphyrinogen oxidase CpMB16_01500 ENOG4108RH7 phosphoglycerate mutase CpMB16_01510 ENOG4107QIV Cytochrome c biogenesis protein CpMB16_01520 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) CpMB16_01535 ENOG4105DQ5 transport system permease protein CpMB16_01540 ENOG4105CRE cytochrome C CpMB16_01570 ENOG4105CEE C4-dicarboxylate transporter CpMB16_01575 ENOG4107TCW O-succinylbenzoate synthase CpMB16_01590 ENOG4105BZF Glycosyl transferase (Group 1 CpMB16_01600 ENOG4105C80 Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity) CpMB16_01605 ENOG4105P52 geranylgeranyl reductase CpMB16_01635 ENOG410683Z Preprotein translocase SecE subunit CpMB16_01660 ENOG4105CTZ aminopeptidase c CpMB16_01665 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase CpMB16_01685 ENOG4105DSE periplasmic solute binding protein CpMB16_01695 ENOG4105DIK (ABC) transporter CpMB16_01700 ENOG4105CC5 ABC transporter CpMB16_01725 ENOG4105BZU Histidine kinase CpMB16_01730 ENOG4105WH1 Two component transcriptional regulator luxr family CpMB16_01735 ENOG4105CJ1 ABC, transporter CpMB16_01750 ENOG4108PJD permease CpMB16_01820 ENOG4105VBF alkaline shock protein CpMB16_01825 ENOG4108Z10 Involved in the binding of tRNA to the ribosomes (By similarity) CpMB16_01915 ENOG4105C44 Serine transporter CpMB16_01920 ENOG4105EJQ L-serine dehydratase CpMB16_01925 ENOG4105HDK L-asparaginase CpMB16_01965 ENOG4108IUE nitrate reductase beta subunit CpMB16_01995 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) CpMB16_02005 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) CpMB16_02060 ENOG4105EG2 ABC transporter, permease CpMB16_02080 ENOG4108IJ9 (ABC) transporter CpMB16_02085 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) CpMB16_02135 ENOG4108ZT0 50S ribosomal protein l17 CpMB16_02165 ENOG4105EC2 ftsk spoIIIe CpMB16_02220 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) CpMB16_02270 ENOG4105KIU Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) CpMB16_02285 ENOG4108VT4 CpMB16_02295 ENOG4107QVP Dehydrogenase CpMB16_02340 ENOG4108UMI ABC transporter, permease CpMB16_02350 ENOG4105D01 (LipO)protein CpMB16_02360 ENOG4105D01 (LipO)protein CpMB16_02370 ENOG4105DSE periplasmic solute binding protein CpMB16_02375 ENOG4105DIK (ABC) transporter CpMB16_02380 ENOG4107RBD ABC, transporter CpMB16_02385 ENOG4107RPQ ABC transporter CpMB16_02390 ENOG4107R5H iron (metal) dependent repressor, dtxr family CpMB16_02395 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) CpMB16_02400 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) CpMB16_02435 ENOG4105DQ5 transport system permease protein CpMB16_02440 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) CpMB16_02450 ENOG4108IQK o-acetylhomoserine CpMB16_02455 ENOG4105E9K Isocitrate dehydrogenase CpMB16_02460 ENOG4105F27 Major Facilitator CpMB16_02480 ENOG4105C31 Tryptophanyl-tRNA synthetase CpMB16_02485 ENOG4107H3J ribonuclease CpMB16_02525 ENOG4107QSU Phosphoglucomutase phosphomannomutase alpha beta alpha domain CpMB16_02530 ENOG4107RM1 amidohydrolase CpMB16_02540 ENOG4108JIJ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second (By similarity) CpMB16_02555 ENOG4108JIK carboxylase CpMB16_02560 ENOG4105KHC sulfurtransferase CpMB16_02565 ENOG4105D7Z glutathione synthase CpMB16_02570 ENOG4105EXC Acyl-transferase CpMB16_02580 ENOG4107WR6 Maf-like protein CpMB16_02585 ENOG4108RVA ribokinase CpMB16_02590 ENOG4105ETE Transcriptional regulator (LacI family CpMB16_02600 ENOG4105D8K carboxyl transferase CpMB16_02605 ENOG4105D8K carboxyl transferase CpMB16_02610 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase CpMB16_02660 ENOG4107TB5 TRANSCRIPTIONal CpMB16_02680 ENOG4105K51 Acts as a transcriptional regulator. Probably redox- responsive. The apo- but not holo-form probably binds DNA (By similarity) CpMB16_02705 ENOG4105EIP mannose-6-phosphate isomerase CpMB16_02730 ENOG4105CK6 Two component transcriptional regulator (Winged helix family CpMB16_02735 ENOG4105BZU Histidine kinase CpMB16_02750 ENOG4108S7Q sigma 54 modulation protein ribosomal protein S30ea CpMB16_02790 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase CpMB16_02795 ENOG4108RAV Conserved protein CpMB16_02800 ENOG4108Z66 YbaK ebsC protein CpMB16_02835 ENOG4105C1J atp-dependent rna helicase CpMB16_02870 ENOG4105E09 nadh pyrophosphatase CpMB16_02895 ENOG41063PX domain protein CpMB16_02970 ENOG4105C85 amino acid CpMB16_02975 ENOG4107QSA Oxaloacetate decarboxylase CpMB16_02980 ENOG4107QX3 carboxylase CpMB16_02990 ENOG4107QSA Oxaloacetate decarboxylase CpMB16_03000 ENOG4107TK4 histidinol-phosphate phosphatase CpMB16_03005 ENOG4107TK4 histidinol-phosphate phosphatase CpMB16_03020 ENOG4105CFC Transporter CpMB16_03030 ENOG4105CAK Cell division ATP-binding protein ftsE CpMB16_03035 ENOG4107RYD Part of the ABC transporter FtsEX involved in cellular division (By similarity) CpMB16_03060 ENOG4107B2H carbonic anhydrase CpMB16_03075 ENOG4105CM4 permease protein CpMB16_03080 ENOG4108IPW abc transporter atp-binding protein CpMB16_03115 ENOG4105CFI type iii restriction protein res subunit CpMB16_03125 ENOG4105MS9 Resuscitation-promoting factor CpMB16_03150 ENOG4105C7N Xanthine uracil vitamin C permease CpMB16_03155 ENOG4105FCS tRNA rRNA methyltransferase CpMB16_03175 ENOG4105BZN citrate synthase CpMB16_03180 ENOG41081K0 peptidylprolyl cis-trans isomerase CpMB16_03195 ENOG4105CV8 reductase CpMB16_03200 ENOG4108VUG Enoyl-CoA hydratase CpMB16_03210 ENOG4107QN1 sodium solute CpMB16_03220 ENOG4108WKN secreted protein CpMB16_03235 ENOG4107QI1 Mate efflux family protein CpMB16_03260 ENOG4108J59 Extracellular solute-binding protein, family 5 CpMB16_03265 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component CpMB16_03275 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) CpMB16_03315 ENOG4108RM3 Phosphatase with a broad specificity. Its primary physiological function is to dephosphorylate 3'-phosphoadenosine 5'-phosphate (PAP) and 3'-phosphoadenosine 5'-phosphosulfate (PAPS). Thus, plays a role in mycobacterial sulfur metabolism, since it can serve as a key regulator of the sulfate assimilation pathway by controlling the pools of PAP and PAPS in the cell. To a lesser extent, is also able to hydrolyze inositol 1-phosphate (I- 1-P), fructose 1,6-bisphosphate (FBP) (to fructose 6-phosphate (F- 6-P)) and AMP in vitro, but this might has no significance in vivo CpMB16_03320 ENOG4107QRT dEAD DEAH box helicase CpMB16_03330 ENOG4108S0J Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized pyrimidines, such as thymine glycol, 5,6-dihydrouracil and 5,6-dihydrothymine. Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'- phosphates (By similarity) CpMB16_03360 ENOG41061JJ Peptidase family M23 CpMB16_03385 ENOG4107UBR Extracellular solute-binding protein family 3 CpMB16_03390 ENOG4108Q1T ABC transporter CpMB16_03395 ENOG4105DRP amino acid AbC transporter CpMB16_03405 ENOG4105EC0 Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity) CpMB16_03435 ENOG4105NRA 50s ribosomal protein l31 type b CpMB16_03445 ENOG4105ETX regulatoR CpMB16_03450 ENOG41062D9 Histidine kinase CpMB16_03455 ENOG4105C0H protease CpMB16_03460 ENOG4108YXW Together with MoaA, is involved in the conversion of 5'- GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) CpMB16_03485 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase CpMB16_03505 ENOG4108VGI doxx family CpMB16_03530 ENOG4105FF9 glycosyl transferase, family 39 CpMB16_03540 ENOG4105C94 Transporter CpMB16_03545 ENOG4108K88 Membrane CpMB16_03560 ENOG4105F8V Hydrolase, tatD family CpMB16_03565 ENOG4106839 domain protein CpMB16_03580 ENOG4105C5H ABC transporter CpMB16_03595 ENOG4105CSR polyphosphate kinase 2 CpMB16_03605 ENOG410667J hydrolase CpMB16_03635 ENOG4108HGY Proline imino-peptidase CpMB16_03640 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) CpMB16_03650 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) CpMB16_03655 ENOG4105EA8 2-Nitropropane dioxygenase CpMB16_03675 ENOG4108IUM Glycogen debranching enzyme CpMB16_03680 ENOG4105C5T Phosphoribosyl pyrophosphate synthase CpMB16_03685 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) CpMB16_03700 ENOG41082JN Transcriptional regulator CpMB16_03710 ENOG4105D5Q Arginine ornithine antiporter CpMB16_03715 ENOG4105DXN mazG family CpMB16_03775 ENOG4105T1M mycothiol conjugate amidase mca CpMB16_03875 ENOG4105DQ6 Transposase CpMB16_03890 ENOG4105C3G gtp-binding protein CpMB16_03905 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA CpMB16_03910 ENOG4105BZ1 (ABC) transporter CpMB16_03915 ENOG4105BZ1 (ABC) transporter CpMB16_03920 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) CpMB16_03925 ENOG4105CKW Inner membrane protein yedI CpMB16_03935 ENOG4105NSK ABC superfamily ATP binding cassette transporter membrane protein CpMB16_03940 ENOG4108JJB ABC transporter CpMB16_03950 ENOG4105CAT Cytidine monophosphate kinase CpMB16_03960 ENOG4108J59 Extracellular solute-binding protein, family 5 CpMB16_03965 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component CpMB16_03970 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component CpMB16_03980 ENOG4108TVX serine protease CpMB16_04000 ENOG4105CI3 gtp-binding protein typa CpMB16_04020 ENOG4108Z4U Ferredoxin CpMB16_04040 ENOG4105C85 amino acid CpMB16_04050 ENOG4105C85 amino acid CpMB16_04070 ENOG4105EEI dihydropteroate synthase CpMB16_04075 ENOG4105C3Q Glycosyl transferase, family 2 CpMB16_04100 ENOG4107FQX Alpha-acetolactate decarboxylase CpMB16_04105 ENOG4107QPH glycogen) synthase CpMB16_04115 ENOG4107ZBN O-methyltransferase CpMB16_04145 ENOG4105CJW magnesium transporter CpMB16_04155 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 CpMB16_04160 ENOG4105BZ1 (ABC) transporter CpMB16_04175 ENOG4105EBR Carboxylesterase CpMB16_04195 ENOG4107WI4 Aldose-1-epimerase CpMB16_04215 ENOG4105CRD Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity) CpMB16_04245 ENOG4105CK7 Sodium proline symporter CpMB16_04250 ENOG4105C0D helicase CpMB16_04275 ENOG4105FS7 Transcriptional regulator CpMB16_04305 ENOG41080R8 Conserved Protein CpMB16_04310 ENOG4107QR9 Iron-sulfur cluster binding protein CpMB16_04315 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) CpMB16_04320 ENOG4105DAA L-lactate CpMB16_04330 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) CpMB16_04335 ENOG4105D6E homoserine dehydrogenase CpMB16_04385 ENOG4107UH5 it plays a direct role in the translocation of protons across the membrane (By similarity) CpMB16_04390 ENOG4105ZA1 atp synthase CpMB16_04395 ENOG4107Z0K Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0) (By similarity) CpMB16_04465 ENOG4105DKW ABC transporter CpMB16_04485 ENOG4105C10 Electron transfer flavoprotein CpMB16_04550 ENOG4105EHG Permease protein CpMB16_04555 ENOG4105E0A ABC, transporter CpMB16_04565 ENOG4105CTQ phosphohexokinase CpMB16_04575 ENOG4105CPC Aldo Keto reductase CpMB16_04585 ENOG4105CXD Specific inhibitor of chromosomal initiation of replication in vitro. Binds the three 13-mers in the origin (oriC) to block initiation of replication (By similarity) CpMB16_04615 ENOG4105C7K acetolactate synthase CpMB16_04650 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) CpMB16_04670 ENOG4105ERH Fumarylacetoacetate hydrolase CpMB16_04755 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) CpMB16_04760 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) CpMB16_04765 ENOG4105DP4 dak2 domain fusion protein ylov CpMB16_04775 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit CpMB16_04780 ENOG4106H78 methyltransferase CpMB16_04800 ENOG4108JEH abc transporter atp-binding protein CpMB16_04805 ENOG4105E5Q amino acid AbC transporter CpMB16_04855 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) CpMB16_04860 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) CpMB16_04870 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) CpMB16_04890 ENOG4105EEM helicase CpMB16_04915 ENOG41084BS 50S ribosomal protein L35 CpMB16_04945 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase CpMB16_04960 ENOG4105C8Y Acetylornithine aminotransferase CpMB16_04980 ENOG4105CH7 arginosuccinase CpMB16_04985 ENOG4105W49 UPF0434 protein CpMB16_05020 ENOG4105DSU hydrolase CpMB16_05055 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) CpMB16_05065 ENOG4108KVX Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves (By similarity) CpMB16_05075 ENOG4105DUX Transporter CpMB16_05080 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) CpMB16_05090 ENOG4105K8I Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves (By similarity) CpMB16_05105 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) CpMB16_05110 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter CpMB16_05115 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) CpMB16_05120 ENOG4108SEA Esterase CpMB16_05125 ENOG4105FF5 Membrane CpMB16_05130 ENOG4108HUF Transporter CpMB16_05135 ENOG4105DQ5 transport system permease protein CpMB16_05140 ENOG4108U1V ABC transporter, permease CpMB16_05145 ENOG4105E0A ABC, transporter CpMB16_05150 ENOG4105DUU IucA IucC family protein CpMB16_05165 ENOG4105K5B UPF0225 protein CpMB16_05180 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving CpMB16_05220 ENOG4105C37 (CBS) domain CpMB16_05225 ENOG4105C1J atp-dependent rna helicase CpMB16_05230 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) CpMB16_05240 ENOG4105D7N magnesium and cobalt transport protein CorA CpMB16_05260 ENOG4105CSH Transporter CpMB16_05285 ENOG4106N3V dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83) CpMB16_05300 ENOG4105CTK cobaltochelatase, cobn subunit CpMB16_05335 ENOG4108RG3 short-chain dehydrogenase reductase CpMB16_05350 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) CpMB16_05360 ENOG4107TMB Transcriptional regulator CpMB16_05380 ENOG4105E5F proteasome CpMB16_05395 ENOG4105DFM M18 family aminopeptidase CpMB16_05415 ENOG4108IJ0 Aspartate ammonia-lyase CpMB16_05420 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter CpMB16_05440 ENOG4105C3R Methionine synthase CpMB16_05460 ENOG4107SET aldo keto reductase CpMB16_05470 ENOG4107QYT Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) CpMB16_05495 ENOG4108UTZ Dihydroxyacetone kinase CpMB16_05500 ENOG4105CMT Dihydroxyacetone kinase CpMB16_05515 ENOG4105C5H ABC transporter CpMB16_05580 ENOG4105ZXU NLP P60 protein CpMB16_05610 ENOG4105CAG UPF0210 protein CpMB16_05630 ENOG4105C5H ABC transporter CpMB16_05635 ENOG4105VG1 fes assembly suf system protein CpMB16_05640 ENOG4108UNV SUF system FeS assembly protein, NifU family CpMB16_05650 ENOG4105C3K feS assembly ATPase SufC CpMB16_05670 ENOG4107JC6 Membrane CpMB16_05695 ENOG4105CV1 Transketolase (EC 2.2.1.1) CpMB16_05700 ENOG4107QQX Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) CpMB16_05740 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase CpMB16_05750 ENOG4105CHW UPF0052 protein CpMB16_05760 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) CpMB16_05790 ENOG4105DJV ribulose-phosphate 3-epimerase CpMB16_05805 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) CpMB16_05850 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain CpMB16_05860 ENOG4105CD3 dihydroorotase CpMB16_05900 ENOG4105DC7 peptidase M24 CpMB16_05920 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase CpMB16_05930 ENOG4105E2X shikimate dehydrogenase CpMB16_05940 ENOG41080G3 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) CpMB16_05990 ENOG4108UZX fmn reductase CpMB16_05995 ENOG4105EJQ L-serine dehydratase CpMB16_06020 ENOG4105C5X domain protein CpMB16_06025 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) CpMB16_06040 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) CpMB16_06055 ENOG4107RTU Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) CpMB16_06090 ENOG4105C29 acyl-CoA thioesterase CpMB16_06105 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) CpMB16_06120 ENOG4107YQ3 lipid a biosynthesis lauroyl acyltransferase CpMB16_06140 ENOG4105DBE peroxidase CpMB16_06215 ENOG4105E0X reductase CpMB16_06220 ENOG4107JTW chlorite dismutase CpMB16_06305 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) CpMB16_06345 ENOG4105JNJ Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) CpMB16_06350 ENOG4105D3R alkyl hydroperoxide reductase CpMB16_06355 ENOG4105C5Q Transcriptional regulator CpMB16_06365 ENOG4105CQ7 ATP-dependent helicase CpMB16_06390 ENOG4105E98 transcriptional regulator DeoR family CpMB16_06395 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) CpMB16_06400 ENOG4105E98 transcriptional regulator DeoR family CpMB16_06405 ENOG4105DE4 1-phosphofructokinase CpMB16_06410 ENOG4105DM4 PTS System CpMB16_06420 ENOG4105KRI phosphocarrier protein (HPr CpMB16_06425 ENOG41079Y2 Catalyzes the coenzyme F420-dependent oxidation of glucose 6-phosphate (G6P) to 6-phosphogluconolactone CpMB16_06435 ENOG4105C2W permease CpMB16_06440 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) CpMB16_06455 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) CpMB16_06470 ENOG4105C99 atpase involved in dna repair CpMB16_06505 ENOG4107ZYJ bioY protein CpMB16_06510 ENOG4108JJB ABC transporter CpMB16_06515 ENOG4105EK6 Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity) CpMB16_06525 ENOG4105WBV Transcriptional regulator CpMB16_06560 ENOG4105CN5 Metallo-Beta-Lactamase CpMB16_06600 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) CpMB16_06615 ENOG4107QMU Mate efflux family protein CpMB16_06660 ENOG4107XFJ UPF0246 protein CpMB16_06665 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) CpMB16_06670 ENOG4105CNG UPF0061 protein CpMB16_06675 ENOG4105CKI cobalamin synthesis protein CpMB16_06680 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) CpMB16_06690 ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase CpMB16_06745 ENOG4105DZP Membrane-associated zinc metalloprotease CpMB16_06755 ENOG41068X0 Protein of unknown function (DUF2631) CpMB16_06800 ENOG4108IYT Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) CpMB16_06810 ENOG4105C0P Mg chelatase subunit ChlI CpMB16_06830 ENOG4107QYR Signal peptidase i CpMB16_06845 ENOG4105DM4 PTS System CpMB16_06855 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) CpMB16_06860 ENOG4107XUM An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) CpMB16_06880 ENOG4105E1P Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity) CpMB16_06915 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) CpMB16_06940 ENOG4105DCF alanine dehydrogenase CpMB16_06945 ENOG4107R37 Glutamate dehydrogenase CpMB16_06950 ENOG4105BZW Glycerate kinase CpMB16_06965 ENOG4105CH2 amidohydrolase CpMB16_06985 ENOG4105CA9 Pyruvate kinase CpMB16_06995 ENOG4105DK0 Indole-3-glycerol phosphate synthase CpMB16_07015 ENOG4108MWI inositol mono-phosphatase CpMB16_07105 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein CpMB16_07110 ENOG4105C7B Threonine dehydratase CpMB16_07135 ENOG4107ZIW This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) CpMB16_07150 ENOG4105HDK L-asparaginase CpMB16_07170 ENOG4107VQS DivIVA family CpMB16_07180 ENOG4105VR5 Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity) CpMB16_07185 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase CpMB16_07190 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) CpMB16_07200 ENOG4105DFU Cell wall formation (By similarity) CpMB16_07230 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) CpMB16_07235 ENOG4105CJN penicillin-binding protein CpMB16_07285 ENOG41072RD Membrane CpMB16_07290 ENOG4105KYH transcriptional regulatory protein CpMB16_07300 ENOG4105C7V phospho-2-dehydro-3-deoxyheptonate aldolase CpMB16_07320 ENOG4105DKQ ROK family CpMB16_07325 ENOG4105JNK Glycosyl transferase (Group 1 CpMB16_07335 ENOG4105K4H Nlp p60 protein CpMB16_07385 ENOG4108YZT Adenosylcobinamide kinase CpMB16_07390 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) CpMB16_07400 ENOG4105CM2 brancheD-chain amino acid aminotransferase CpMB16_07420 ENOG4105CBI The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor CpMB16_07425 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) CpMB16_07460 ENOG4105C5F glutamine synthetase CpMB16_07515 ENOG410836F Transposase CpMB16_07545 ENOG4105D3Y Na H antiporter CpMB16_07550 ENOG4105E09 nadh pyrophosphatase CpMB16_07555 ENOG4105D98 threonine synthase CpMB16_07580 ENOG4105C5F glutamine synthetase CpMB16_07605 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) CpMB16_07615 ENOG4105CVJ phosphoglycerate mutase CpMB16_07625 ENOG4105EGD dinuclear metal center protein, YbgI family CpMB16_07650 ENOG4105DH2 Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group (By similarity) CpMB16_07665 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) CpMB16_07670 ENOG4108YIQ Alpha beta hydrolase CpMB16_07695 ENOG4105EN6 Membrane CpMB16_07765 ENOG4105D9H Catalyzes the attachment of glycine to tRNA(Gly) (By similarity) CpMB16_07795 ENOG4106DBE Involved in DNA repair and RecF pathway recombination (By similarity) CpMB16_07850 ENOG4108IQE Amp-dependent synthetase and ligase CpMB16_07870 ENOG4105DGW oligopeptidase A CpMB16_07875 ENOG4105EBR Carboxylesterase CpMB16_07900 ENOG4105BZ1 (ABC) transporter CpMB16_07905 ENOG4105CWM branched-chain amino acid transport system II carrier protein CpMB16_07920 ENOG4105C94 Transporter CpMB16_07935 ENOG4105DEF Extracellular solute-binding protein, family 5 CpMB16_07945 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component CpMB16_07950 ENOG4108JQ5 ABC transporter CpMB16_07960 ENOG4105DFA alanine racemase domain protein CpMB16_07965 ENOG4105CUC YeeE YedE family protein CpMB16_07990 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) CpMB16_07995 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) CpMB16_08015 ENOG4105CCF Lysine exporter protein (Lyse ygga) CpMB16_08035 ENOG4105KQC Competence protein CpMB16_08040 ENOG4107Z8D degv family CpMB16_08045 ENOG4105CVJ phosphoglycerate mutase CpMB16_08055 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) CpMB16_08070 ENOG4105WD1 Membrane CpMB16_08075 ENOG4105D0C transport protein CpMB16_08100 ENOG4105C03 ribonuclease CpMB16_08115 ENOG4105CIF Ornithine Cyclodeaminase CpMB16_08125 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase CpMB16_08165 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation CpMB16_08190 ENOG4105EUB pirin domain protein CpMB16_08200 ENOG4105MC2 DSBA oxidoreductase CpMB16_08210 ENOG4105D8X mechanosensitive ion channel CpMB16_08290 ENOG4108M15 ABC transporter CpMB16_08295 ENOG4105E4J Cytochrome c oxidase caa3-type, assembly factor ctag-related protein CpMB16_08300 ENOG4105D22 carbon starvation protein CpMB16_08315 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin CpMB16_08320 ENOG4105D3Z quinone oxidoreductase, yhdh yhfp family CpMB16_08325 ENOG4105EMU Dehydrogenase CpMB16_08345 ENOG4107UBC ErfK ybiS ycfS ynhG family protein CpMB16_08385 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein CpMB16_08390 ENOG4108RWI nicotinamidase CpMB16_08435 ENOG4105WH1 Two component transcriptional regulator luxr family CpMB16_08485 ENOG4108RQ5 Beta-lactamase domain-containing protein CpMB16_08510 ENOG4107RKP Nicotinate phosphoribosyltransferase CpMB16_08650 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) CpMB16_08660 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) CpMB16_08665 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) CpMB16_08670 ENOG4105WAZ (Glutaredoxin-like protein) NrdH CpMB16_08680 ENOG4107RA1 nh(3)-dependent nad( ) synthetase CpMB16_08700 ENOG4105C59 p-type ATPase CpMB16_08735 ENOG4107QIX Phosphoglucomutase (EC 5.4.2.2 CpMB16_08750 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) CpMB16_08755 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) CpMB16_08805 ENOG4105D7W serine acetyltransferase CpMB16_08845 ENOG4105C4M (Ubiquinol oxidase) subunit I CpMB16_08850 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii CpMB16_08855 ENOG4108JJ9 ABC, transporter CpMB16_08860 ENOG4108JJ9 ABC, transporter CpMB16_08885 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) CpMB16_08915 ENOG4105CBD Diacylglycerol kinase CpMB16_08930 ENOG4106XY2 Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity) CpMB16_08955 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) CpMB16_08960 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) CpMB16_08970 ENOG4108JIU phosphoribosylformylglycinamidine synthase ii CpMB16_08975 ENOG4105D21 Phosphoribosylformylglycinamidine synthase I CpMB16_08980 ENOG410839H phosphoribosylformylglycinamidine synthase CpMB16_08985 ENOG4108V06 Glutathione peroxidase CpMB16_09005 ENOG4105C83 adenylosuccinate lyase CpMB16_09010 ENOG4107ZYR domain protein CpMB16_09015 ENOG4105CZN Potassium uptake protein CpMB16_09020 ENOG4105C12 Phosphoribosylglycinamide synthetase CpMB16_09025 ENOG4107ZUX Histidine triad (HIT) protein CpMB16_09035 ENOG4105BZU Histidine kinase CpMB16_09040 ENOG4105CK6 Two component transcriptional regulator (Winged helix family CpMB16_09045 ENOG4105C57 major facilitator superfamily CpMB16_09070 ENOG4105C7K acetolactate synthase CpMB16_09125 ENOG4105C2N RNA methyltransferase TrmH family group 3 CpMB16_09145 ENOG4108VJ1 Transcriptional regulator (CarD family CpMB16_09165 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) CpMB16_09175 ENOG4108V9Q carbonic anhydrase CpMB16_09195 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit CpMB16_09205 ENOG41080V3 Major Facilitator superfamily CpMB16_09210 ENOG4105DU0 nucleoside hydrolase CpMB16_09225 ENOG4105CRK lysyL-tRNA synthetase CpMB16_09245 ENOG4105C26 Dehydrogenase CpMB16_09250 ENOG4105C94 Transporter CpMB16_09260 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) CpMB16_09290 ENOG4105EEI dihydropteroate synthase CpMB16_09295 ENOG4105EUJ GTP cyclohydrolase i CpMB16_09300 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) CpMB16_09305 ENOG4108UGV hypoxanthine phosphoribosyltransferase CpMB16_09320 ENOG4105F0N pyrophosphate phospho-hydrolase CpMB16_09325 ENOG4105VFE sira family CpMB16_09330 ENOG4107QJT sodium dicarboxylate symporter CpMB16_09355 ENOG4105CSR polyphosphate kinase 2 CpMB16_09375 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) CpMB16_09395 ENOG4105D65 subunit l CpMB16_09400 ENOG4105MKQ Monovalent cation H antiporter subunit C CpMB16_09405 ENOG4108JPZ Monovalent cation H antiporter subunit D CpMB16_09425 ENOG4108U8T Mannosyltransferase CpMB16_09445 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) CpMB16_09450 ENOG4105KEG ribosomal-protein-alanine acetyltransferase CpMB16_09455 ENOG4105CGK Exodeoxyribonuclease III CpMB16_09460 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) CpMB16_09485 ENOG4105CT1 (ABC) transporter CpMB16_09500 ENOG4108IJ2 phosphate acetyltransferase CpMB16_09520 ENOG4108HH9 Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR CpMB16_09525 ENOG4105DYA Acts on guanine, xanthine and to a lesser extent hypoxanthine (By similarity) CpMB16_09555 ENOG4105CRE cytochrome C CpMB16_09560 ENOG4105EBH Required during biogenesis of c-type cytochromes (cytochrome c6 and cytochrome f) at the step of heme attachment (By similarity) CpMB16_09570 ENOG4105EAU Plays a role in nitrite reduction (By similarity) CpMB16_09575 ENOG4108W6G cytochrome C CpMB16_09635 ENOG4107RCW fructose-bisphosphate aldolase CpMB16_09650 ENOG41065E1 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) CpMB16_09665 ENOG4105C6V Glycerol-3-phosphate dehydrogenase CpMB16_09725 ENOG410836F Transposase CpMB16_09760 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) CpMB16_09765 ENOG4105C19 ABC transporter CpMB16_09795 ENOG4105C26 Dehydrogenase CpMB16_09810 ENOG4105KNI merR family transcriptional Regulator CpMB16_09825 ENOG4105CFG Acts as a chaperone (By similarity) CpMB16_09855 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component CpMB16_09880 ENOG4105DF6 Fe-S oxidoreductase CpMB16_09895 ENOG4105E0A ABC, transporter CpMB16_09900 ENOG4108ESU Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Involved in the translocation of the substrate across the membrane (By similarity) CpMB16_09910 ENOG4105ICD Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) CpMB16_09915 ENOG4107S16 Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG (By similarity) CpMB16_09920 ENOG4108YH3 Required for maturation of urease via the functional incorporation of the urease nickel metallocenter (By similarity) CpMB16_09925 ENOG4105HFU Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly (By similarity) CpMB16_09930 ENOG4105CQM Urea amidohydrolase subunit alpha CpMB16_09935 ENOG4105KI2 Urea amidohydrolase subunit beta CpMB16_09940 ENOG4108YZ9 Urea amidohydrolase subunit gamma CpMB16_09965 ENOG4105CRK lysyL-tRNA synthetase CpMB16_09985 ENOG4105C6Y Udp-glucose 6-dehydrogenase CpMB16_10000 ENOG4105C26 Dehydrogenase CpMB16_10010 ENOG4107QPA Cleaves GlcNAc linked beta-1,4 to MurNAc tripeptides (By similarity) CpMB16_10020 ENOG41073B4 coagulation factor 5 8 type domain-containing protein CpMB16_10025 ENOG4105EXC Acyl-transferase CpMB16_10040 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) CpMB16_10045 ENOG4108M6P methyltransferase CpMB16_10090 ENOG4105D8K carboxyl transferase CpMB16_10095 ENOG4107EEY synthase CpMB16_10100 ENOG4107RCI amp-dependent synthetase and ligase CpMB16_10115 ENOG4107YB1 Trehalose corynomycolyl transferase CpMB16_10130 ENOG4107ISF Involved in the biosynthesis of the arabinogalactan (AG) region of the mycolylarabinogalactan-peptidoglycan (mAGP) complex, an essential component the mycobacterial cell wall. Catalyzes the transfer of arabinofuranosyl (Araf) residues residue from the sugar donor beta-D-arabinofuranosyl-1-monophosphoryldecaprenol (DPA) to the arabinan domain to form terminal beta-(1- 2)-linked Araf residues, which marks the end point for AG arabinan biosynthesis before decoration with mycolic acids CpMB16_10135 ENOG4106YN8 Prenyltransferase CpMB16_10145 ENOG410602S Transferase CpMB16_10165 ENOG4108QXE glycerophosphoryl diester phosphodiesterase CpMB16_10170 ENOG4105CXY transporter CpMB16_10185 ENOG4105EHG Permease protein CpMB16_10190 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) CpMB16_10200 ENOG4108KP7 hydrolase CpMB16_10215 ENOG4105FDP GntR family transcriptional regulator CpMB16_10235 ENOG4105CQC Prephenate dehydratase CpMB16_10240 ENOG4105DV0 amidase (EC 3.5.1.4 CpMB16_10250 ENOG4108KGH TRANSCRIPTIONal CpMB16_10270 ENOG4105EXC Acyl-transferase CpMB16_10315 ENOG4108YYH Nadph-dependent fmn reductase CpMB16_10320 ENOG4105D94 Major Facilitator Superfamily CpMB16_10340 ENOG4108VJY integral membrane protein CpMB16_10360 ENOG4105WH1 Two component transcriptional regulator luxr family CpMB16_10375 ENOG4108RN7 integral membrane protein CpMB16_10380 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins CpMB16_10455 ENOG41080RH Thioredoxin CpMB16_10470 ENOG41079KZ Major Facilitator Superfamily CpMB16_10520 ENOG4105BZ4 penicillin-binding protein CpMB16_10540 ENOG4108RKS Short-chain dehydrogenase reductase Sdr CpMB16_10555 ENOG4107XFB conserved TRANSMEMBRANE PROTEIN CpMB16_10560 ENOG4105DPV During stationary phase, binds the chromosome non- specifically, forming a highly ordered and stable dps-DNA co- crystal within which chromosomal DNA is condensed and protected from diverse damages. It protects DNA from oxidative damage by sequestering intracellular Fe(2 ) ion and storing it in the form of Fe(3 ) oxyhydroxide mineral, which can be released after reduction. One hydrogen peroxide oxidizes two Fe(2 ) ions, which prevents hydroxyl radical production by the Fenton reaction CpMB16_10565 ENOG4108S0J Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized pyrimidines, such as thymine glycol, 5,6-dihydrouracil and 5,6-dihydrothymine. Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'- phosphates (By similarity) CpMB16_10580 ENOG4105ECB domain protein CpMB16_10590 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) CpMB16_10605 ENOG4105ENE Histidine kinase CpMB16_10610 ENOG4105WH1 Two component transcriptional regulator luxr family CpMB16_10625 ENOG4105CE4 GlcNAc 6-P deacetylase CpMB16_10640 ENOG4107EJG GntR family transcriptional regulator CpMB16_10645 ENOG4105DEF Extracellular solute-binding protein, family 5 CpMB16_10650 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component CpMB16_10660 ENOG4108JQ7 (ABC) transporter CpMB16_10665 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) CpMB16_10705 ENOG4106178 UPF0339 protein CpMB16_10720 ENOG4107QV7 Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system) (By similarity) CpMB16_10730 ENOG4105EWK phytoene CpMB16_10740 ENOG4105CRQ synthase (Component I) CpMB16_10745 ENOG4105RGK anthranilate synthase component ii CpMB16_10755 ENOG4105DK0 Indole-3-glycerol phosphate synthase CpMB16_10775 ENOG4105DHU Bile acid CpMB16_10785 ENOG4105KMT branched-chain amino acid CpMB16_10790 ENOG4108UMN azlc family CpMB16_10795 ENOG4108UJU UPF0301 protein CpMB16_10800 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate CpMB16_10820 ENOG4105EMN RNA polymerase sigma factor CpMB16_10825 ENOG4105C3M thioredoxin reductase CpMB16_10830 ENOG4105K63 Thioredoxin CpMB16_10835 ENOG4108E1C hydrolase CpMB16_10850 ENOG4107QJE Chromosome Partitioning Protein CpMB16_10875 ENOG41084CH 50S ribosomal protein l34