locus-tag	class	description
CpMB16_00015	COG0592	DNA-directed DNA polymerase activity
CpMB16_00030	COG0187	DNA topoisomerase II activity
CpMB16_00050	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CpMB16_00135	COG1518	maintenance of DNA repeat elements
CpMB16_00180	COG1120	ATPase activity
CpMB16_00185	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CpMB16_00190	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CpMB16_00195	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CpMB16_00205	COG0515	serine threonine protein kinase
CpMB16_00205	COG2815	serine threonine protein kinase
CpMB16_00210	COG0515	serine threonine protein kinase
CpMB16_00215	COG0768	penicillin binding
CpMB16_00220	COG0772	Belongs to the SEDS family
CpMB16_00235	COG1716	ATPase activity
CpMB16_00235	COG1716	ATPase activity
CpMB16_00285	COG2239	Acts as a magnesium transporter
CpMB16_00290	COG0366	Alpha amylase catalytic
CpMB16_00345	COG0517	IMP dehydrogenase activity
CpMB16_00345	COG1125	glycine betaine transport
CpMB16_00360	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CpMB16_00380	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
CpMB16_00390	COG3409	Peptidoglycan-binding domain 1 protein
CpMB16_00390	COG3757	hydrolase, family 25
CpMB16_00415	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
CpMB16_00440	COG1846	Transcriptional regulator
CpMB16_00455	COG3180	Ammonia monooxygenase
CpMB16_00465	COG0730	response to heat
CpMB16_00480	COG1643	Atp-dependent helicase
CpMB16_00485	COG3145	DNA-N1-methyladenine dioxygenase activity
CpMB16_00490	COG0519	Catalyzes the synthesis of GMP from XMP
CpMB16_00500	COG0393	Putative heavy-metal-binding
CpMB16_00505	COG2501	S4 domain
CpMB16_00530	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
CpMB16_00535	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
CpMB16_00545	COG3590	peptidase
CpMB16_00575	COG1028	Short-chain dehydrogenase reductase Sdr
CpMB16_00580	COG0277	FAD linked oxidase domain protein
CpMB16_00610	COG1216	Glycosyl transferase, family 2
CpMB16_00615	COG0803	Belongs to the bacterial solute-binding protein 9 family
CpMB16_00620	COG1121	(ABC) transporter
CpMB16_00625	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CpMB16_00630	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CpMB16_00635	COG0803	Belongs to the bacterial solute-binding protein 9 family
CpMB16_00660	COG0604	alcohol dehydrogenase
CpMB16_00720	COG0471	metal ion transport
CpMB16_00730	COG1263	PTS System
CpMB16_00730	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CpMB16_00735	COG1263	PTS System
CpMB16_00735	COG2190	(PTS) system
CpMB16_00735	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CpMB16_00760	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CpMB16_00775	COG0287	Prephenate dehydrogenase
CpMB16_00785	COG0590	tRNA wobble adenosine to inosine editing
CpMB16_00795	COG2409	Drug exporters of the RND superfamily
CpMB16_00800	COG0343	queuine tRNA-ribosyltransferase activity
CpMB16_00810	COG2610	gluconate transmembrane transporter activity
CpMB16_00815	COG3265	gluconokinase activity
CpMB16_00820	COG1063	alcohol dehydrogenase
CpMB16_00825	COG1028	Short-chain dehydrogenase reductase Sdr
CpMB16_00840	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CpMB16_00865	COG2610	gluconate transmembrane transporter activity
CpMB16_00870	COG2084	Dehydrogenase
CpMB16_00880	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CpMB16_00885	COG0179	Fumarylacetoacetate (FAA) hydrolase
CpMB16_00895	COG3442	glutamine amidotransferase
CpMB16_00900	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
CpMB16_00910	COG0778	Nitroreductase
CpMB16_00915	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
CpMB16_00920	COG2390	Transcriptional regulator
CpMB16_00925	COG0813	purine-nucleoside phosphorylase activity
CpMB16_00940	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CpMB16_00960	COG0697	spore germination
CpMB16_00965	COG0527	aspartate kinase activity
CpMB16_01005	COG3842	ATPase activity
CpMB16_01015	COG1840	ABC-type Fe3 transport system, periplasmic component
CpMB16_01020	COG2271	Major facilitator Superfamily
CpMB16_01060	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CpMB16_01060	COG2111	Na H antiporter
CpMB16_01090	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CpMB16_01115	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CpMB16_01135	COG0494	nUDIX hydrolase
CpMB16_01205	COG1111	helicase
CpMB16_01205	COG1205	dead DEAH box helicase
CpMB16_01215	COG1754	DNA topoisomerase type I activity
CpMB16_01215	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CpMB16_01220	COG1297	OPT oligopeptide transporter protein
CpMB16_01230	COG0470	DNA polymerase III
CpMB16_01245	COG0318	PFAM AMP-dependent synthetase and ligase
CpMB16_01255	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
CpMB16_01265	COG1088	dTDP-glucose 4,6-dehydratase activity
CpMB16_01275	COG1505	serine-type exopeptidase activity
CpMB16_01290	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CpMB16_01295	COG1396	sequence-specific DNA binding
CpMB16_01295	COG3800	Transcriptional regulator
CpMB16_01305	COG1053	succinate dehydrogenase
CpMB16_01310	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
CpMB16_01320	COG2733	membrane
CpMB16_01330	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
CpMB16_01350	COG1882	Formate acetyltransferase
CpMB16_01370	COG0318	PFAM AMP-dependent synthetase and ligase
CpMB16_01385	COG5002	protein histidine kinase activity
CpMB16_01390	COG0745	RESPONSE REGULATOR receiver
CpMB16_01410	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
CpMB16_01430	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CpMB16_01430	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
CpMB16_01440	COG0560	Phosphoserine phosphatase
CpMB16_01460	COG1648	precorrin-2 dehydrogenase activity
CpMB16_01460	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CpMB16_01475	COG2217	Heavy metal translocating P-type atpase
CpMB16_01500	COG0406	alpha-ribazole phosphatase activity
CpMB16_01510	COG0785	Cytochrome C biogenesis protein
CpMB16_01520	COG0275	rRNA processing
CpMB16_01535	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CpMB16_01540	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CpMB16_01570	COG3069	C4-dicarboxylate transmembrane transporter activity
CpMB16_01575	COG4948	Mandelate Racemase Muconate Lactonizing
CpMB16_01590	COG0438	transferase activity, transferring glycosyl groups
CpMB16_01590	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CpMB16_01600	COG0039	L-malate dehydrogenase activity
CpMB16_01605	COG0644	oxidoreductase
CpMB16_01635	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CpMB16_01660	COG3579	cysteine-type endopeptidase activity
CpMB16_01665	COG1902	pentaerythritol trinitrate reductase activity
CpMB16_01685	COG0803	Belongs to the bacterial solute-binding protein 9 family
CpMB16_01695	COG1121	(ABC) transporter
CpMB16_01700	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CpMB16_01730	COG2197	response regulator
CpMB16_01735	COG1131	(ABC) transporter
CpMB16_01750	COG0701	Predicted permease
CpMB16_01820	COG1302	Protein conserved in bacteria
CpMB16_01825	COG0051	transcription antitermination factor activity, RNA binding
CpMB16_01915	COG0814	amino acid
CpMB16_01920	COG1760	l-serine dehydratase
CpMB16_01925	COG0252	asparaginase activity
CpMB16_01965	COG1140	nitrate reductase beta subunit
CpMB16_01995	COG0315	cyclic pyranopterin monophosphate synthase activity
CpMB16_02005	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
CpMB16_02055	COG1175	transmembrane transport
CpMB16_02060	COG3833	ABC-type maltose transport systems, permease component
CpMB16_02080	COG3842	ATPase activity
CpMB16_02085	COG0201	protein transport
CpMB16_02135	COG0203	ribosomal protein L17
CpMB16_02155	COG1404	Belongs to the peptidase S8 family
CpMB16_02165	COG1674	ftsk spoiiie
CpMB16_02220	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CpMB16_02295	COG0516	GMP reductase activity
CpMB16_02340	COG2011	ABC-type metal ion transport system permease component
CpMB16_02350	COG1464	Belongs to the NlpA lipoprotein family
CpMB16_02360	COG1464	Belongs to the NlpA lipoprotein family
CpMB16_02370	COG0803	Belongs to the bacterial solute-binding protein 9 family
CpMB16_02375	COG1121	(ABC) transporter
CpMB16_02385	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CpMB16_02385	COG1321	iron dependent repressor
CpMB16_02390	COG1321	iron dependent repressor
CpMB16_02395	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
CpMB16_02400	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
CpMB16_02435	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CpMB16_02440	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
CpMB16_02450	COG2873	o-acetylhomoserine
CpMB16_02455	COG2838	Isocitrate dehydrogenase
CpMB16_02460	COG2814	Major facilitator Superfamily
CpMB16_02480	COG0180	Tryptophanyl-tRNA synthetase
CpMB16_02485	COG1295	ribonuclease BN
CpMB16_02525	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CpMB16_02530	COG1473	amidohydrolase
CpMB16_02530	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
CpMB16_02540	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
CpMB16_02545	COG2814	Major facilitator Superfamily
CpMB16_02555	COG4770	biotin carboxylase activity
CpMB16_02560	COG2897	thiosulfate sulfurtransferase activity
CpMB16_02565	COG0189	ligase activity
CpMB16_02570	COG2755	lipolytic protein G-D-S-L family
CpMB16_02570	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
CpMB16_02580	COG0424	maF-like protein
CpMB16_02585	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CpMB16_02590	COG1609	Transcriptional regulator
CpMB16_02600	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CpMB16_02605	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CpMB16_02610	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
CpMB16_02610	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
CpMB16_02660	COG1316	TRANSCRIPTIONal
CpMB16_02670	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
CpMB16_02705	COG1482	cell wall glycoprotein biosynthetic process
CpMB16_02730	COG0745	RESPONSE REGULATOR receiver
CpMB16_02735	COG5002	protein histidine kinase activity
CpMB16_02750	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
CpMB16_02790	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
CpMB16_02795	COG2135	peptidase activity
CpMB16_02800	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
CpMB16_02835	COG0513	Belongs to the DEAD box helicase family
CpMB16_02870	COG2816	NAD+ diphosphatase activity
CpMB16_02895	COG3480	Lon protease (S16) C-terminal proteolytic domain
CpMB16_03000	COG0483	inositol monophosphate 1-phosphatase activity
CpMB16_03005	COG0483	inositol monophosphate 1-phosphatase activity
CpMB16_03020	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
CpMB16_03030	COG2884	Cell division ATP-binding protein ftsE
CpMB16_03035	COG2177	Part of the ABC transporter FtsEX involved in
CpMB16_03060	COG0288	reversible hydration of carbon dioxide
CpMB16_03115	COG1061	Type III restriction enzyme res subunit
CpMB16_03125	COG1652	LysM domain
CpMB16_03150	COG2252	PERMEase
CpMB16_03155	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CpMB16_03175	COG0372	Belongs to the citrate synthase family
CpMB16_03180	COG0545	Peptidyl-prolyl cis-trans isomerase
CpMB16_03195	COG0656	L-ascorbic acid biosynthetic process
CpMB16_03200	COG1024	Enoyl-CoA hydratase
CpMB16_03210	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CpMB16_03220	COG3757	hydrolase, family 25
CpMB16_03235	COG0534	Mate efflux family protein
CpMB16_03240	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CpMB16_03245	COG0019	diaminopimelate decarboxylase activity
CpMB16_03260	COG4166	transmembrane transport
CpMB16_03315	COG1218	3'(2'),5'-bisphosphate nucleotidase
CpMB16_03320	COG1201	RNA secondary structure unwinding
CpMB16_03330	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
CpMB16_03360	COG0739	heme binding
CpMB16_03385	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CpMB16_03390	COG0765	amino acid transport
CpMB16_03395	COG0765	amino acid transport
CpMB16_03435	COG0254	rRNA binding
CpMB16_03445	COG0745	RESPONSE REGULATOR receiver
CpMB16_03450	COG2205	protein histidine kinase activity
CpMB16_03455	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CpMB16_03460	COG0521	Mo-molybdopterin cofactor biosynthetic process
CpMB16_03460	COG0315	cyclic pyranopterin monophosphate synthase activity
CpMB16_03485	COG1210	Utp--glucose-1-phosphate uridylyltransferase
CpMB16_03505	COG2259	Doxx family
CpMB16_03530	COG1928	C-terminal four TMM region of protein-O-mannosyltransferase
CpMB16_03540	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CpMB16_03545	COG3949	Membrane
CpMB16_03560	COG0084	hydrolase, TatD family'
CpMB16_03565	COG3583	domain protein
CpMB16_03580	COG0488	(ABC) transporter
CpMB16_03595	COG2326	polyphosphate kinase activity
CpMB16_03605	COG0561	phosphatase activity
CpMB16_03635	COG0596	Alpha beta hydrolase
CpMB16_03640	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
CpMB16_03650	COG0193	aminoacyl-tRNA hydrolase activity
CpMB16_03655	COG2070	2-Nitropropane dioxygenase
CpMB16_03675	COG1523	belongs to the glycosyl hydrolase 13 family
CpMB16_03680	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CpMB16_03685	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
CpMB16_03700	COG1309	transcriptional regulator
CpMB16_03710	COG0531	amino acid
CpMB16_03715	COG3956	TIGRFAM MazG family protein
CpMB16_03775	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
CpMB16_03845	COG0114	fumarate hydratase activity
CpMB16_03850	COG1494	fructose-1,6-bisphosphatase
CpMB16_03875	COG2801	Transposase and inactivated derivatives
CpMB16_03890	COG0012	GTP binding
CpMB16_03905	COG2824	Alkylphosphonate utilization operon protein PhnA
CpMB16_03910	COG1132	(ABC) transporter
CpMB16_03915	COG1132	(ABC) transporter
CpMB16_03920	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CpMB16_03925	COG2354	Protein conserved in bacteria
CpMB16_03935	COG4721	ABC-type cobalt transport system, permease component
CpMB16_03940	COG1122	ATPase activity
CpMB16_03950	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
CpMB16_03960	COG4166	transmembrane transport
CpMB16_03965	COG0601	transmembrane transport
CpMB16_03980	COG5640	endopeptidase activity
CpMB16_04005	COG4166	transmembrane transport
CpMB16_04040	COG1113	amino acid transport
CpMB16_04050	COG1113	amino acid transport
CpMB16_04060	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CpMB16_04065	COG1611	Belongs to the LOG family
CpMB16_04070	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
CpMB16_04075	COG0463	Glycosyl transferase, family 2
CpMB16_04100	COG3527	Alpha-acetolactate decarboxylase
CpMB16_04105	COG0297	glycogen (starch) synthase activity
CpMB16_04115	COG4122	O-methyltransferase activity
CpMB16_04145	COG2239	Acts as a magnesium transporter
CpMB16_04155	COG0508	dehydrogenase complex catalyzes the overall conversion of
CpMB16_04155	COG0567	Dehydrogenase, E1 component
CpMB16_04160	COG1132	(ABC) transporter
CpMB16_04175	COG2272	Belongs to the type-B carboxylesterase lipase family
CpMB16_04195	COG2017	converts alpha-aldose to the beta-anomer
CpMB16_04215	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
CpMB16_04245	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CpMB16_04250	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CpMB16_04275	COG1846	Transcriptional regulator
CpMB16_04305	COG1556	Lactate utilization protein
CpMB16_04310	COG1139	Iron-sulfur cluster binding protein
CpMB16_04315	COG0247	lactate metabolic process
CpMB16_04320	COG1620	l-lactate permease
CpMB16_04330	COG0019	diaminopimelate decarboxylase activity
CpMB16_04335	COG0460	homoserine dehydrogenase
CpMB16_04385	COG0356	it plays a direct role in the translocation of protons across the membrane
CpMB16_04390	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CpMB16_04395	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
CpMB16_04465	COG1119	ATPase activity
CpMB16_04485	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
CpMB16_04550	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CpMB16_04555	COG1120	ATPase activity
CpMB16_04565	COG0205	6-phosphofructokinase activity
CpMB16_04575	COG0667	Aldo Keto reductase
CpMB16_04585	COG0583	DNA-binding transcription factor activity
CpMB16_04610	COG0668	transmembrane transport
CpMB16_04615	COG0028	Belongs to the TPP enzyme family
CpMB16_04650	COG0473	3-isopropylmalate dehydrogenase activity
CpMB16_04670	COG0179	Fumarylacetoacetate (FAA) hydrolase
CpMB16_04755	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
CpMB16_04760	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
CpMB16_04765	COG1461	Dihydroxyacetone kinase
CpMB16_04775	COG0511	ligase activity, forming carbon-carbon bonds
CpMB16_04780	COG0742	ribosomal rna small subunit methyltransferase
CpMB16_04805	COG0765	amino acid transport
CpMB16_04855	COG2226	methyltransferase
CpMB16_04860	COG0539	negative regulation of cytoplasmic translation
CpMB16_04870	COG0237	dephospho-CoA kinase activity
CpMB16_04890	COG3973	AAA domain
CpMB16_04915	COG0291	Belongs to the bacterial ribosomal protein bL35 family
CpMB16_04930	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CpMB16_04945	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
CpMB16_04960	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CpMB16_04980	COG0165	Argininosuccinate lyase
CpMB16_04985	COG2835	tetraacyldisaccharide 4'-kinase activity
CpMB16_05020	COG0647	UMP catabolic process
CpMB16_05055	COG4974	Belongs to the 'phage' integrase family
CpMB16_05075	COG3104	oligopeptide transport
CpMB16_05080	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CpMB16_05090	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
CpMB16_05105	COG1160	GTP binding
CpMB16_05110	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
CpMB16_05120	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
CpMB16_05125	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
CpMB16_05130	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
CpMB16_05135	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CpMB16_05140	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CpMB16_05145	COG1120	ATPase activity
CpMB16_05150	COG4264	IucA IucC family
CpMB16_05165	COG3012	SEC-C Motif Domain Protein
CpMB16_05180	COG0653	protein targeting
CpMB16_05220	COG1253	flavin adenine dinucleotide binding
CpMB16_05225	COG0513	Belongs to the DEAD box helicase family
CpMB16_05230	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
CpMB16_05240	COG0598	Magnesium transport protein CorA
CpMB16_05260	COG0477	Major facilitator Superfamily
CpMB16_05285	COG0463	Glycosyl transferase, family 2
CpMB16_05335	COG0300	oxidoreductase activity
CpMB16_05350	COG0805	protein transport
CpMB16_05360	COG2378	regulation of single-species biofilm formation
CpMB16_05380	COG4122	O-methyltransferase activity
CpMB16_05395	COG1362	aminopeptidase activity
CpMB16_05415	COG1027	Aspartate ammonia-lyase
CpMB16_05420	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
CpMB16_05440	COG1410	methionine synthase
CpMB16_05440	COG0646	methionine synthase
CpMB16_05460	COG0667	Aldo Keto reductase
CpMB16_05470	COG0167	dihydroorotate dehydrogenase activity
CpMB16_05495	COG1461	Dihydroxyacetone kinase
CpMB16_05500	COG2376	Dihydroxyacetone kinase
CpMB16_05580	COG3883	PFAM NLP P60 protein
CpMB16_05580	COG0791	NLP P60 protein
CpMB16_05610	COG2848	UPF0210 protein
CpMB16_05625	COG1388	LysM domain
CpMB16_05625	COG4932	domain protein
CpMB16_05630	COG0488	(ABC) transporter
CpMB16_05635	COG2151	metal-sulfur cluster biosynthetic enzyme
CpMB16_05640	COG0822	iron-sulfur transferase activity
CpMB16_05650	COG0396	ATPase activity
CpMB16_05695	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
CpMB16_05700	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
CpMB16_05720	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CpMB16_05740	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
CpMB16_05750	COG0391	Required for morphogenesis under gluconeogenic growth conditions
CpMB16_05760	COG0322	excinuclease ABC activity
CpMB16_05790	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
CpMB16_05805	COG0242	peptide deformylase activity
CpMB16_05850	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
CpMB16_05860	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
CpMB16_05875	COG1090	epimerase
CpMB16_05900	COG0006	proline dipeptidase activity
CpMB16_05905	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
CpMB16_05910	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
CpMB16_05915	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
CpMB16_05920	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
CpMB16_05930	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CpMB16_05940	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
CpMB16_05995	COG1760	l-serine dehydratase
CpMB16_06020	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CpMB16_06025	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
CpMB16_06040	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CpMB16_06055	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CpMB16_06060	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CpMB16_06090	COG1946	Acyl-CoA thioesterase
CpMB16_06105	COG0156	8-amino-7-oxononanoate synthase activity
CpMB16_06120	COG1560	Kdo2-lipid A biosynthetic process
CpMB16_06140	COG2837	iron assimilation
CpMB16_06215	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CpMB16_06305	COG2890	protein-(glutamine-N5) methyltransferase activity
CpMB16_06345	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CpMB16_06350	COG0450	alkyl hydroperoxide reductase
CpMB16_06365	COG1643	Atp-dependent helicase
CpMB16_06390	COG1349	DNA-binding transcription factor activity
CpMB16_06395	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CpMB16_06400	COG1349	DNA-binding transcription factor activity
CpMB16_06405	COG1105	Belongs to the carbohydrate kinase PfkB family
CpMB16_06410	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
CpMB16_06410	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CpMB16_06410	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CpMB16_06420	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CpMB16_06425	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CpMB16_06435	COG2233	PERMEase
CpMB16_06440	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
CpMB16_06455	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
CpMB16_06470	COG1196	nuclear chromosome segregation
CpMB16_06490	COG2137	regulation of response to DNA damage stimulus
CpMB16_06495	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
CpMB16_06505	COG1268	BioY protein
CpMB16_06510	COG1122	ATPase activity
CpMB16_06525	COG1396	sequence-specific DNA binding
CpMB16_06545	COG0861	Integral membrane protein TerC family
CpMB16_06550	COG1674	ftsk spoiiie
CpMB16_06560	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
CpMB16_06600	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
CpMB16_06615	COG0534	Mate efflux family protein
CpMB16_06660	COG3022	response to hydroperoxide
CpMB16_06665	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CpMB16_06665	COG1648	precorrin-2 dehydrogenase activity
CpMB16_06670	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
CpMB16_06675	COG0523	cobalamin synthesis protein
CpMB16_06680	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CpMB16_06680	COG2169	Transcriptional regulator
CpMB16_06745	COG0750	zinc metalloprotease
CpMB16_06800	COG4974	Belongs to the 'phage' integrase family
CpMB16_06810	COG0606	chelatase, subunit chli
CpMB16_06830	COG0681	Belongs to the peptidase S26 family
CpMB16_06845	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CpMB16_06845	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CpMB16_06845	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CpMB16_06855	COG0336	Belongs to the RNA methyltransferase TrmD family
CpMB16_06860	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
CpMB16_06880	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
CpMB16_06910	COG1115	amino acid carrier protein
CpMB16_06915	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
CpMB16_06940	COG0686	Belongs to the AlaDH PNT family
CpMB16_06945	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
CpMB16_06950	COG1929	Belongs to the glycerate kinase type-1 family
CpMB16_06965	COG1473	amidohydrolase
CpMB16_06975	COG0058	SHG alpha-glucan phosphorylase activity
CpMB16_06985	COG0469	pyruvate kinase activity
CpMB16_06995	COG0134	indole-3-glycerol-phosphate synthase activity
CpMB16_07015	COG0483	inositol monophosphate 1-phosphatase activity
CpMB16_07105	COG1739	Uncharacterized protein family UPF0029
CpMB16_07110	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CpMB16_07135	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
CpMB16_07150	COG0252	asparaginase activity
CpMB16_07170	COG3599	regulation of cell shape
CpMB16_07180	COG1799	cell septum assembly
CpMB16_07190	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
CpMB16_07200	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CpMB16_07230	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CpMB16_07235	COG0768	penicillin binding
CpMB16_07300	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
CpMB16_07320	COG1940	carbohydrate kinase activity
CpMB16_07325	COG0438	transferase activity, transferring glycosyl groups
CpMB16_07335	COG0791	NLP P60 protein
CpMB16_07385	COG2087	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate
CpMB16_07390	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
CpMB16_07400	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CpMB16_07415	COG0508	dehydrogenase complex catalyzes the overall conversion of
CpMB16_07420	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CpMB16_07420	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CpMB16_07425	COG0404	The glycine cleavage system catalyzes the degradation of glycine
CpMB16_07430	COG0509	glycine decarboxylation via glycine cleavage system
CpMB16_07460	COG0174	glutamine synthetase
CpMB16_07515	COG3547	Transposase (IS116 IS110 IS902 family)
CpMB16_07545	COG2056	Na+-H+ antiporter family
CpMB16_07555	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
CpMB16_07580	COG0174	glutamine synthetase
CpMB16_07605	COG0557	exoribonuclease II activity
CpMB16_07615	COG0406	alpha-ribazole phosphatase activity
CpMB16_07615	COG0328	RNA-DNA hybrid ribonuclease activity
CpMB16_07625	COG3323	Protein of unknown function (DUF1653)
CpMB16_07625	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
CpMB16_07665	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
CpMB16_07670	COG0596	Alpha beta hydrolase
CpMB16_07695	COG2860	membrane
CpMB16_07765	COG0423	glycine-tRNA ligase activity
CpMB16_07795	COG1381	Involved in DNA repair and RecF pathway recombination
CpMB16_07850	COG1022	Amp-dependent synthetase and ligase
CpMB16_07900	COG1132	(ABC) transporter
CpMB16_07905	COG1114	Component of the transport system for branched-chain amino acids
CpMB16_07920	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CpMB16_07935	COG0747	negative chemotaxis
CpMB16_07940	COG0601	transmembrane transport
CpMB16_07945	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CpMB16_07950	COG4172	Belongs to the ABC transporter superfamily
CpMB16_07960	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
CpMB16_07965	COG2391	methyltransferase activity
CpMB16_07975	COG0601	transmembrane transport
CpMB16_07990	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CpMB16_07995	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
CpMB16_08015	COG1280	lysine exporter protein (LysE YggA)
CpMB16_08035	COG1555	photosystem II stabilization
CpMB16_08035	COG1596	polysaccharide export
CpMB16_08040	COG1307	EDD domain protein, DegV family
CpMB16_08045	COG0406	alpha-ribazole phosphatase activity
CpMB16_08055	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
CpMB16_08070	COG2832	Protein of unknown function (DUF454)
CpMB16_08075	COG0569	domain protein
CpMB16_08075	COG2985	domain, Protein
CpMB16_08100	COG1530	ribonuclease E activity
CpMB16_08115	COG2423	ornithine cyclodeaminase activity
CpMB16_08125	COG0285	dihydrofolate synthase activity
CpMB16_08165	COG0544	peptidyl-prolyl cis-trans isomerase activity
CpMB16_08200	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
CpMB16_08210	COG0668	transmembrane transport
CpMB16_08290	COG1131	(ABC) transporter
CpMB16_08295	COG3336	cytochrome c oxidase
CpMB16_08300	COG1966	Carbon starvation protein
CpMB16_08320	COG0604	alcohol dehydrogenase
CpMB16_08325	COG4221	oxidoreductase activity
CpMB16_08345	COG1376	ErfK ybiS ycfS ynhG family protein
CpMB16_08385	COG2130	NADP-dependent
CpMB16_08390	COG1335	isochorismatase
CpMB16_08435	COG2197	response regulator
CpMB16_08485	COG1234	tRNA 3'-trailer cleavage
CpMB16_08510	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
CpMB16_08650	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CpMB16_08660	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CpMB16_08680	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
CpMB16_08700	COG2217	Heavy metal translocating P-type atpase
CpMB16_08735	COG0033	Phosphoglucomutase
CpMB16_08750	COG1136	(ABC) transporter
CpMB16_08750	COG0577	efflux transmembrane transporter activity
CpMB16_08755	COG1136	(ABC) transporter
CpMB16_08755	COG0577	efflux transmembrane transporter activity
CpMB16_08790	COG2197	response regulator
CpMB16_08805	COG1045	serine acetyltransferase
CpMB16_08825	COG0371	Dehydrogenase
CpMB16_08845	COG1271	oxidase subunit
CpMB16_08850	COG1294	oxidase, subunit
CpMB16_08855	COG4988	ABC transporter
CpMB16_08860	COG4988	ABC transporter
CpMB16_08885	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CpMB16_08915	COG1597	lipid kinase activity
CpMB16_08930	COG0354	folic acid binding
CpMB16_08955	COG1780	Probably involved in ribonucleotide reductase function
CpMB16_08960	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CpMB16_08970	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CpMB16_08975	COG0047	phosphoribosylformylglycinamidine synthase activity
CpMB16_08980	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CpMB16_08985	COG0386	Belongs to the glutathione peroxidase family
CpMB16_09005	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
CpMB16_09010	COG0569	domain protein
CpMB16_09015	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CpMB16_09020	COG0151	Belongs to the GarS family
CpMB16_09025	COG0537	adenosine 5'-monophosphoramidase activity
CpMB16_09035	COG2205	protein histidine kinase activity
CpMB16_09040	COG0745	RESPONSE REGULATOR receiver
CpMB16_09070	COG0028	Belongs to the TPP enzyme family
CpMB16_09115	COG1609	Transcriptional regulator
CpMB16_09125	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CpMB16_09145	COG1329	Transcriptional regulator
CpMB16_09150	COG2847	Copper chaperone PCu(A)C
CpMB16_09165	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
CpMB16_09175	COG0288	reversible hydration of carbon dioxide
CpMB16_09195	COG0542	response to heat
CpMB16_09205	COG0477	Major facilitator Superfamily
CpMB16_09210	COG1957	nucleoside hydrolase
CpMB16_09225	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
CpMB16_09240	COG1301	dicarboxylic acid transport
CpMB16_09250	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CpMB16_09255	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
CpMB16_09260	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
CpMB16_09290	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
CpMB16_09295	COG0302	gtp cyclohydrolase
CpMB16_09300	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CpMB16_09320	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
CpMB16_09325	COG0425	Belongs to the sulfur carrier protein TusA family
CpMB16_09325	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CpMB16_09330	COG1301	dicarboxylic acid transport
CpMB16_09355	COG2326	polyphosphate kinase activity
CpMB16_09375	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CpMB16_09395	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CpMB16_09395	COG2111	Na H antiporter
CpMB16_09425	COG1051	belongs to the nudix hydrolase family
CpMB16_09445	COG0242	peptide deformylase activity
CpMB16_09450	COG0456	acetyltransferase
CpMB16_09455	COG0708	Exodeoxyribonuclease III
CpMB16_09460	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CpMB16_09485	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CpMB16_09500	COG0280	phosphate acetyltransferase
CpMB16_09520	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
CpMB16_09525	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
CpMB16_09555	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CpMB16_09560	COG1333	cytochrome c biogenesis protein
CpMB16_09570	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
CpMB16_09575	COG3005	denitrification pathway
CpMB16_09600	COG4129	membrane
CpMB16_09635	COG0191	fructose-bisphosphate aldolase activity
CpMB16_09650	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
CpMB16_09665	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
CpMB16_09725	COG3547	Transposase (IS116 IS110 IS902 family)
CpMB16_09760	COG0577	efflux transmembrane transporter activity
CpMB16_09760	COG1136	(ABC) transporter
CpMB16_09765	COG1136	(ABC) transporter
CpMB16_09795	COG1012	belongs to the aldehyde dehydrogenase family
CpMB16_09810	COG0789	Transcriptional regulator
CpMB16_09825	COG0443	Heat shock 70 kDa protein
CpMB16_09855	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CpMB16_09860	COG0601	transmembrane transport
CpMB16_09880	COG2181	nitrate reductase activity
CpMB16_09880	COG0247	lactate metabolic process
CpMB16_09895	COG1120	ATPase activity
CpMB16_09900	COG4139	cobalamin transport
CpMB16_09910	COG0829	nickel cation binding
CpMB16_09915	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
CpMB16_09920	COG0830	nickel cation binding
CpMB16_09925	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
CpMB16_09930	COG0804	urea catabolic process
CpMB16_09935	COG0832	Belongs to the urease beta subunit family
CpMB16_09940	COG0831	urea catabolic process
CpMB16_09965	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
CpMB16_09965	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
CpMB16_09985	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
CpMB16_10000	COG1012	belongs to the aldehyde dehydrogenase family
CpMB16_10010	COG1472	Belongs to the glycosyl hydrolase 3 family
CpMB16_10020	COG4981	capsule polysaccharide biosynthetic process
CpMB16_10025	COG2755	lipolytic protein G-D-S-L family
CpMB16_10025	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
CpMB16_10040	COG0438	transferase activity, transferring glycosyl groups
CpMB16_10045	COG0500	methyltransferase
CpMB16_10090	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CpMB16_10095	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CpMB16_10095	COG3321	synthase
CpMB16_10100	COG0318	PFAM AMP-dependent synthetase and ligase
CpMB16_10115	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
CpMB16_10115	COG5479	isomerase activity
CpMB16_10130	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
CpMB16_10135	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
CpMB16_10140	COG0671	phosphoesterase, PA-phosphatase related
CpMB16_10145	COG1216	Glycosyl transferase, family 2
CpMB16_10165	COG0584	glycerophosphoryl diester phosphodiesterase
CpMB16_10170	COG2271	Major facilitator Superfamily
CpMB16_10185	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CpMB16_10190	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CpMB16_10200	COG0561	phosphatase activity
CpMB16_10215	COG2188	Transcriptional regulator
CpMB16_10235	COG0077	Prephenate dehydratase
CpMB16_10240	COG0154	amidase activity
CpMB16_10250	COG1316	TRANSCRIPTIONal
CpMB16_10315	COG0431	NADPH-dependent FMN reductase
CpMB16_10320	COG2814	Major facilitator Superfamily
CpMB16_10340	COG5650	phosphatidylinositol metabolic process
CpMB16_10360	COG2197	response regulator
CpMB16_10375	COG3764	Sortase (surface protein transpeptidase)
CpMB16_10380	COG0706	membrane insertase activity
CpMB16_10405	COG0564	pseudouridine synthase activity
CpMB16_10455	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CpMB16_10470	COG0477	Major facilitator Superfamily
CpMB16_10475	COG0305	Participates in initiation and elongation during chromosome replication
CpMB16_10520	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CpMB16_10540	COG0300	oxidoreductase activity
CpMB16_10555	COG0586	Pfam SNARE associated Golgi protein
CpMB16_10560	COG0783	Belongs to the Dps family
CpMB16_10565	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
CpMB16_10570	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
CpMB16_10570	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
CpMB16_10580	COG1511	domain protein
CpMB16_10590	COG1136	(ABC) transporter
CpMB16_10590	COG0577	efflux transmembrane transporter activity
CpMB16_10605	COG4585	Histidine kinase
CpMB16_10610	COG2197	response regulator
CpMB16_10625	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
CpMB16_10640	COG2186	Transcriptional regulator
CpMB16_10645	COG0747	negative chemotaxis
CpMB16_10650	COG0601	transmembrane transport
CpMB16_10655	COG0444	Belongs to the ABC transporter superfamily
CpMB16_10660	COG4608	Belongs to the ABC transporter superfamily
CpMB16_10665	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CpMB16_10705	COG3422	double-strand break repair
CpMB16_10720	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
CpMB16_10740	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
CpMB16_10745	COG0512	Glutamine amidotransferase of anthranilate synthase
CpMB16_10755	COG0135	phosphoribosylanthranilate isomerase activity
CpMB16_10755	COG0134	indole-3-glycerol-phosphate synthase activity
CpMB16_10785	COG1687	branched-chain amino acid
CpMB16_10790	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
CpMB16_10795	COG1678	Uncharacterized ACR, COG1678
CpMB16_10800	COG0617	tRNA 3'-terminal CCA addition
CpMB16_10835	COG0860	N-Acetylmuramoyl-L-alanine amidase
CpMB16_10835	COG3409	Peptidoglycan-binding domain 1 protein
CpMB16_10850	COG1192	Involved in chromosome partitioning
CpMB16_10865	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
CpMB16_10875	COG0230	Belongs to the bacterial ribosomal protein bL34 family