locus-tag	class	description
I6I74_00010	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
I6I74_00030	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6I74_00040	COG1760	l-serine dehydratase
I6I74_00050	COG0124	histidyl-tRNA synthetase
I6I74_00055	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6I74_00060	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
I6I74_00065	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
I6I74_00080	COG0737	Belongs to the 5'-nucleotidase family
I6I74_00085	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I6I74_00095	COG0747	negative chemotaxis
I6I74_00100	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I6I74_00105	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I6I74_00115	COG2255	four-way junction helicase activity
I6I74_00120	COG0632	four-way junction helicase activity
I6I74_00125	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
I6I74_00130	COG0217	transcriptional regulatory protein
I6I74_00135	COG1946	Acyl-CoA thioesterase
I6I74_00150	COG0438	transferase activity, transferring glycosyl groups
I6I74_00155	COG1560	Kdo2-lipid A biosynthetic process
I6I74_00160	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
I6I74_00170	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
I6I74_00175	COG2837	iron assimilation
I6I74_00245	COG3253	May function as heme-dependent peroxidase
I6I74_00255	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
I6I74_00260	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
I6I74_00265	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
I6I74_00295	COG0483	inositol monophosphate 1-phosphatase activity
I6I74_00325	COG2890	protein-(glutamine-N5) methyltransferase activity
I6I74_00335	COG0814	amino acid
I6I74_00340	COG1760	l-serine dehydratase
I6I74_00355	COG1321	iron dependent repressor
I6I74_00360	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I6I74_00380	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I6I74_00405	COG1643	Atp-dependent helicase
I6I74_00410	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
I6I74_00415	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
I6I74_00420	COG1349	DNA-binding transcription factor activity
I6I74_00425	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I6I74_00435	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6I74_00435	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6I74_00435	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
I6I74_00440	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6I74_00450	COG2233	PERMEase
I6I74_00455	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
I6I74_00470	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
I6I74_00485	COG1196	nuclear chromosome segregation
I6I74_00505	COG2137	regulation of response to DNA damage stimulus
I6I74_00510	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
I6I74_00520	COG1268	BioY protein
I6I74_00525	COG1122	ATPase activity
I6I74_00530	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
I6I74_00535	COG1842	Phage shock protein A
I6I74_00540	COG1396	sequence-specific DNA binding
I6I74_00545	COG1546	Belongs to the CinA family
I6I74_00545	COG1058	Belongs to the CinA family
I6I74_00565	COG1674	ftsk spoiiie
I6I74_00575	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
I6I74_00580	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6I74_00585	COG1351	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant
I6I74_00590	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
I6I74_00605	COG1185	polyribonucleotide nucleotidyltransferase activity
I6I74_00610	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
I6I74_00625	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
I6I74_00630	COG2977	Belongs to the P-Pant transferase superfamily
I6I74_00645	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
I6I74_00650	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
I6I74_00660	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
I6I74_00675	COG0779	Required for maturation of 30S ribosomal subunits
I6I74_00695	COG0442	prolyl-tRNA aminoacylation
I6I74_00700	COG3022	response to hydroperoxide
I6I74_00715	COG1131	(ABC) transporter
I6I74_00720	COG2197	response regulator
I6I74_00725	COG4585	Histidine kinase
I6I74_00730	COG0384	phenazine biosynthesis protein PhzF
I6I74_00735	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
I6I74_00740	COG0579	oxidoreductase
I6I74_00770	COG0768	penicillin binding
I6I74_00775	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
I6I74_00785	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
I6I74_00820	COG0233	cytoplasmic translational termination
I6I74_00830	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
I6I74_00845	COG4974	Belongs to the 'phage' integrase family
I6I74_00870	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
I6I74_00880	COG0681	Belongs to the peptidase S26 family
I6I74_00885	COG0335	large ribosomal subunit rRNA binding
I6I74_00905	COG0336	Belongs to the RNA methyltransferase TrmD family
I6I74_00920	COG1309	transcriptional regulator
I6I74_00925	COG0228	four-way junction DNA binding
I6I74_00930	COG2755	lipolytic protein G-D-S-L family
I6I74_00930	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
I6I74_00940	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
I6I74_00965	COG0651	ATP synthesis coupled electron transport
I6I74_00970	COG1006	Multisubunit Na H antiporter MnhC subunit
I6I74_00975	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I6I74_00975	COG2111	Na H antiporter
I6I74_00990	COG1254	Belongs to the acylphosphatase family
I6I74_00995	COG1115	amino acid carrier protein
I6I74_01000	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
I6I74_01005	COG0571	ribonuclease III activity
I6I74_01025	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I6I74_01030	COG1929	Belongs to the glycerate kinase type-1 family
I6I74_01045	COG0058	SHG alpha-glucan phosphorylase activity
I6I74_01075	COG0469	pyruvate kinase activity
I6I74_01080	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
I6I74_01100	COG0107	imidazoleglycerol-phosphate synthase activity
I6I74_01105	COG0483	inositol monophosphate 1-phosphatase activity
I6I74_01115	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
I6I74_01130	COG0131	Imidazoleglycerol-phosphate dehydratase
I6I74_01140	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
I6I74_01170	COG2176	DNA-directed DNA polymerase activity
I6I74_01195	COG1739	Uncharacterized protein family UPF0029
I6I74_01200	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I6I74_01215	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
I6I74_01250	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
I6I74_01265	COG0252	asparaginase activity
I6I74_01275	COG3842	ATPase activity
I6I74_01285	COG1178	ABC-type Fe3 transport system permease component
I6I74_01305	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
I6I74_01320	COG3599	regulation of cell shape
I6I74_01330	COG1799	cell septum assembly
I6I74_01335	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
I6I74_01340	COG1496	oxidoreductase activity
I6I74_01345	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
I6I74_01355	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
I6I74_01360	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
I6I74_01375	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I6I74_01385	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
I6I74_01390	COG0768	penicillin binding
I6I74_01400	COG0275	rRNA processing
I6I74_01425	COG0142	geranyltranstransferase activity
I6I74_01445	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
I6I74_01470	COG1940	carbohydrate kinase activity
I6I74_01475	COG0438	transferase activity, transferring glycosyl groups
I6I74_01495	COG0723	plastoquinol--plastocyanin reductase activity
I6I74_01505	COG1845	cytochrome c oxidase, subunit III
I6I74_01535	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
I6I74_01540	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I6I74_01550	COG1335	isochorismatase
I6I74_01565	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6I74_01570	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
I6I74_01570	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
I6I74_01575	COG0404	The glycine cleavage system catalyzes the degradation of glycine
I6I74_01580	COG0509	glycine decarboxylation via glycine cleavage system
I6I74_01585	COG0321	lipoyl(octanoyl) transferase activity
I6I74_01590	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
I6I74_01605	COG0174	glutamine synthetase
I6I74_01645	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
I6I74_01675	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
I6I74_01680	COG0174	glutamine synthetase
I6I74_01705	COG0557	exoribonuclease II activity
I6I74_01725	COG3323	Protein of unknown function (DUF1653)
I6I74_01725	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
I6I74_01785	COG4974	Belongs to the 'phage' integrase family
I6I74_01800	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
I6I74_01805	COG2267	carboxylic ester hydrolase activity
I6I74_01810	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I6I74_01835	COG1902	pentaerythritol trinitrate reductase activity
I6I74_01840	COG0668	transmembrane transport
I6I74_01850	COG2860	membrane
I6I74_01875	COG1846	Transcriptional regulator
I6I74_01880	COG1764	response to oxidative stress
I6I74_01885	COG1764	response to oxidative stress
I6I74_01910	COG4988	ABC transporter
I6I74_01990	COG2856	Zn peptidase
I6I74_02025	COG1210	Utp--glucose-1-phosphate uridylyltransferase
I6I74_02030	COG0463	Glycosyl transferase, family 2
I6I74_02030	COG1216	Glycosyl transferase, family 2
I6I74_02050	COG2918	glutathione biosynthetic process
I6I74_02050	COG1181	Belongs to the D-alanine--D-alanine ligase family
I6I74_02080	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
I6I74_02110	COG1134	teichoic acid transport
I6I74_02115	COG0438	transferase activity, transferring glycosyl groups
I6I74_02140	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
I6I74_02175	COG0232	Belongs to the dGTPase family. Type 2 subfamily
I6I74_02200	COG0423	glycine-tRNA ligase activity
I6I74_02215	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
I6I74_02220	COG1381	Involved in DNA repair and RecF pathway recombination
I6I74_02235	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I6I74_02245	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
I6I74_02260	COG0484	heat shock protein binding
I6I74_02265	COG1420	regulation of RNA biosynthetic process
I6I74_02280	COG1253	flavin adenine dinucleotide binding
I6I74_02285	COG1253	flavin adenine dinucleotide binding
I6I74_02330	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
I6I74_02340	COG1132	(ABC) transporter
I6I74_02350	COG1114	Component of the transport system for branched-chain amino acids
I6I74_02355	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6I74_02365	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6I74_02370	COG0747	negative chemotaxis
I6I74_02375	COG0601	transmembrane transport
I6I74_02380	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6I74_02385	COG4172	Belongs to the ABC transporter superfamily
I6I74_02400	COG2391	methyltransferase activity
I6I74_02410	COG2197	response regulator
I6I74_02415	COG4585	Histidine kinase
I6I74_02420	COG2197	response regulator
I6I74_02435	COG1473	amidohydrolase
I6I74_02445	COG0481	GTPase activity
I6I74_02455	COG0268	Binds directly to 16S ribosomal RNA
I6I74_02475	COG1280	lysine exporter protein (LysE YggA)
I6I74_02500	COG1307	EDD domain protein, DegV family
I6I74_02510	COG0799	negative regulation of ribosome biogenesis
I6I74_02515	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
I6I74_02525	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I6I74_02545	COG0211	Belongs to the bacterial ribosomal protein bL27 family
I6I74_02550	COG0261	This protein binds to 23S rRNA in the presence of protein L20
I6I74_02555	COG1530	ribonuclease E activity
I6I74_02565	COG0798	PFAM Bile acid sodium symporter
I6I74_02570	COG0640	Transcriptional regulator
I6I74_02575	COG0105	UTP biosynthetic process
I6I74_02590	COG0285	dihydrofolate synthase activity
I6I74_02600	COG0039	L-malate dehydrogenase activity
I6I74_02610	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
I6I74_02615	COG1028	Short-chain dehydrogenase reductase Sdr
I6I74_02635	COG3104	oligopeptide transport
I6I74_02640	COG0740	serine-type endopeptidase activity
I6I74_02655	COG1780	Probably involved in ribonucleotide reductase function
I6I74_02660	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6I74_02665	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6I74_02675	COG0431	NADPH-dependent FMN reductase
I6I74_02680	COG0544	peptidyl-prolyl cis-trans isomerase activity
I6I74_02700	COG0778	Nitroreductase
I6I74_02725	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
I6I74_02735	COG2186	Transcriptional regulator
I6I74_02740	COG4221	oxidoreductase activity
I6I74_02755	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6I74_02780	COG0668	transmembrane transport
I6I74_02790	COG0686	Belongs to the AlaDH PNT family
I6I74_02820	COG0583	DNA-binding transcription factor activity
I6I74_02830	COG4221	oxidoreductase activity
I6I74_02835	COG1115	amino acid carrier protein
I6I74_02850	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6I74_02855	COG1376	ErfK ybiS ycfS ynhG family protein
I6I74_02865	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
I6I74_02870	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6I74_02880	COG2066	Belongs to the glutaminase family
I6I74_02925	COG1882	Formate acetyltransferase
I6I74_02930	COG2233	PERMEase
I6I74_02960	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
I6I74_02965	COG1234	tRNA 3'-trailer cleavage
I6I74_02980	COG3191	aminopeptidase activity
I6I74_02990	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
I6I74_02995	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
I6I74_03010	COG3830	Belongs to the UPF0237 family
I6I74_03010	COG0560	Phosphoserine phosphatase
I6I74_03015	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
I6I74_03020	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6I74_03030	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6I74_03050	COG0257	Belongs to the bacterial ribosomal protein bL36 family
I6I74_03055	COG2814	Major facilitator Superfamily
I6I74_03060	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
I6I74_03075	COG3634	alkyl hydroperoxide reductase activity
I6I74_03095	COG0033	Phosphoglucomutase
I6I74_03100	COG1115	amino acid carrier protein
I6I74_03105	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
I6I74_03110	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
I6I74_03115	COG0577	efflux transmembrane transporter activity
I6I74_03120	COG0577	efflux transmembrane transporter activity
I6I74_03120	COG1136	(ABC) transporter
I6I74_03190	COG2197	response regulator
I6I74_03195	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I6I74_03200	COG1045	serine acetyltransferase
I6I74_03235	COG1937	Protein conserved in bacteria
I6I74_03260	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
I6I74_03280	COG0456	acetyltransferase
I6I74_03290	COG1597	lipid kinase activity
I6I74_03345	COG0252	asparaginase activity
I6I74_03365	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
I6I74_03375	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
I6I74_03405	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
I6I74_03420	COG2205	protein histidine kinase activity
I6I74_03425	COG0745	RESPONSE REGULATOR receiver
I6I74_03430	COG0028	Belongs to the TPP enzyme family
I6I74_03435	COG0477	Major facilitator Superfamily
I6I74_03440	COG1309	transcriptional regulator
I6I74_03460	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
I6I74_03475	COG1609	Transcriptional regulator
I6I74_03480	COG0803	Belongs to the bacterial solute-binding protein 9 family
I6I74_03485	COG3842	ATPase activity
I6I74_03490	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I6I74_03505	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6I74_03520	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
I6I74_03530	COG2847	Copper chaperone PCu(A)C
I6I74_03535	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
I6I74_03550	COG1194	a g-specific adenine glycosylase
I6I74_03560	COG0542	response to heat
I6I74_03570	COG2814	Major facilitator Superfamily
I6I74_03600	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
I6I74_03610	COG1966	Carbon starvation protein
I6I74_03620	COG0003	Pfam Anion-transporting ATPase
I6I74_03630	COG3579	cysteine-type endopeptidase activity
I6I74_03640	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
I6I74_03675	COG0302	gtp cyclohydrolase
I6I74_03680	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I6I74_03690	COG0037	tRNA processing
I6I74_03695	COG2027	D-alanyl-D-alanine carboxypeptidase
I6I74_03700	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
I6I74_03725	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I6I74_03735	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I6I74_03750	COG2326	polyphosphate kinase activity
I6I74_03765	COG0459	protein refolding
I6I74_03770	COG1297	OPT oligopeptide transporter protein
I6I74_03780	COG2111	Na H antiporter
I6I74_03780	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I6I74_03785	COG1006	Multisubunit Na H antiporter MnhC subunit
I6I74_03790	COG0651	ATP synthesis coupled electron transport
I6I74_03800	COG2212	antiporter activity
I6I74_03805	COG1320	monovalent cation:proton antiporter activity
I6I74_03810	COG1051	belongs to the nudix hydrolase family
I6I74_03830	COG0242	peptide deformylase activity
I6I74_03865	COG2176	DNA-directed DNA polymerase activity
I6I74_03935	COG1131	(ABC) transporter
I6I74_03950	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6I74_03975	COG0280	phosphate acetyltransferase
I6I74_03985	COG2153	protein acetylation
I6I74_04030	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
I6I74_04040	COG4129	membrane
I6I74_04050	COG0191	fructose-bisphosphate aldolase activity
I6I74_04065	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
I6I74_04115	COG0789	Transcriptional regulator
I6I74_04130	COG0443	Heat shock 70 kDa protein
I6I74_04150	COG1012	belongs to the aldehyde dehydrogenase family
I6I74_04165	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
I6I74_04205	COG0175	sulfate reduction
I6I74_04230	COG2181	nitrate reductase activity
I6I74_04230	COG0247	lactate metabolic process
I6I74_04255	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
I6I74_04300	COG1132	(ABC) transporter
I6I74_04310	COG1472	Belongs to the glycosyl hydrolase 3 family
I6I74_04325	COG4981	capsule polysaccharide biosynthetic process
I6I74_04350	COG0500	methyltransferase
I6I74_04355	COG1136	(ABC) transporter
I6I74_04370	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
I6I74_04375	COG0220	tRNA (guanine-N7-)-methyltransferase activity
I6I74_04400	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I6I74_04405	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I6I74_04405	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
I6I74_04405	COG3321	synthase
I6I74_04415	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
I6I74_04425	COG5479	isomerase activity
I6I74_04425	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
I6I74_04430	COG1012	belongs to the aldehyde dehydrogenase family
I6I74_04445	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
I6I74_04450	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
I6I74_04460	COG1216	Glycosyl transferase, family 2
I6I74_04490	COG0561	phosphatase activity
I6I74_04495	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
I6I74_04500	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
I6I74_04505	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
I6I74_04515	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
I6I74_04520	COG2188	Transcriptional regulator
I6I74_04540	COG0077	Prephenate dehydratase
I6I74_04555	COG1316	TRANSCRIPTIONal
I6I74_04575	COG1122	ATPase activity
I6I74_04595	COG2353	YceI-like domain
I6I74_04615	COG0617	tRNA 3'-terminal CCA addition
I6I74_04620	COG1678	Uncharacterized ACR, COG1678
I6I74_04625	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
I6I74_04665	COG0159	tryptophan synthase activity
I6I74_04675	COG0135	phosphoribosylanthranilate isomerase activity
I6I74_04675	COG0134	indole-3-glycerol-phosphate synthase activity
I6I74_04680	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I6I74_04685	COG0512	Glutamine amidotransferase of anthranilate synthase
I6I74_04690	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
I6I74_04715	COG0495	leucyl-tRNA aminoacylation
I6I74_04730	COG0604	alcohol dehydrogenase
I6I74_04745	COG2072	flavoprotein involved in K transport
I6I74_04750	COG2197	response regulator
I6I74_04755	COG4585	Histidine kinase
I6I74_04760	COG0577	efflux transmembrane transporter activity
I6I74_04765	COG1136	(ABC) transporter
I6I74_04765	COG0577	efflux transmembrane transporter activity
I6I74_04770	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
I6I74_04770	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
I6I74_04775	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
I6I74_04780	COG4868	Belongs to the UPF0371 family
I6I74_04785	COG1054	Belongs to the UPF0176 family
I6I74_04820	COG1846	Transcriptional regulator
I6I74_04825	COG1260	myo-inositol-1-phosphate synthase
I6I74_04835	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I6I74_04850	COG0360	Binds together with S18 to 16S ribosomal RNA
I6I74_04855	COG0629	single-stranded DNA binding
I6I74_04860	COG0359	binds to the 23S rRNA
I6I74_04865	COG0305	Participates in initiation and elongation during chromosome replication
I6I74_04885	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6I74_04890	COG1842	Phage shock protein A
I6I74_04905	COG1131	(ABC) transporter
I6I74_04930	COG0564	pseudouridine synthase activity
I6I74_04955	COG0706	membrane insertase activity
I6I74_04960	COG3764	Sortase (surface protein transpeptidase)
I6I74_04975	COG4585	Histidine kinase
I6I74_04980	COG2197	response regulator
I6I74_05005	COG2814	Major facilitator Superfamily
I6I74_05020	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I6I74_05170	COG3118	belongs to the thioredoxin family
I6I74_05175	COG0860	N-Acetylmuramoyl-L-alanine amidase
I6I74_05175	COG3409	Peptidoglycan-binding domain 1 protein
I6I74_05190	COG1192	Involved in chromosome partitioning
I6I74_05205	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
I6I74_05210	COG0594	ribonuclease P activity
I6I74_05215	COG0230	Belongs to the bacterial ribosomal protein bL34 family
I6I74_05220	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
I6I74_05225	COG0592	DNA-directed DNA polymerase activity
I6I74_05230	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
I6I74_05240	COG0187	DNA topoisomerase II activity
I6I74_05270	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
I6I74_05290	COG2826	transposase and inactivated derivatives, IS30 family
I6I74_05310	COG1122	ATPase activity
I6I74_05345	COG2890	protein-(glutamine-N5) methyltransferase activity
I6I74_05350	COG2375	cellular response to nickel ion
I6I74_05350	COG1132	(ABC) transporter
I6I74_05355	COG1132	(ABC) transporter
I6I74_05370	COG2315	Protein conserved in bacteria
I6I74_05380	COG2094	Belongs to the DNA glycosylase MPG family
I6I74_05385	COG0726	polysaccharide deacetylase
I6I74_05420	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
I6I74_05430	COG2376	Dihydroxyacetone kinase
I6I74_05465	COG0515	serine threonine protein kinase
I6I74_05465	COG2815	serine threonine protein kinase
I6I74_05470	COG0515	serine threonine protein kinase
I6I74_05475	COG0768	penicillin binding
I6I74_05495	COG1716	ATPase activity
I6I74_05495	COG1716	ATPase activity
I6I74_05505	COG3415	Transposase
I6I74_05505	COG2801	Transposase and inactivated derivatives
I6I74_05520	COG2132	Multicopper oxidase
I6I74_05530	COG0745	RESPONSE REGULATOR receiver
I6I74_05535	COG2205	protein histidine kinase activity
I6I74_05545	COG2217	Heavy metal translocating P-type atpase
I6I74_05595	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I6I74_05600	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
I6I74_05610	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
I6I74_05635	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
I6I74_05650	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
I6I74_05660	COG0659	secondary active sulfate transmembrane transporter activity
I6I74_05665	COG1528	Iron-storage protein
I6I74_05695	COG3180	Ammonia monooxygenase
I6I74_05700	COG0730	response to heat
I6I74_05705	COG1643	Atp-dependent helicase
I6I74_05710	COG0110	maltose O-acetyltransferase activity
I6I74_05735	COG0431	NADPH-dependent FMN reductase
I6I74_05775	COG0393	Putative heavy-metal-binding
I6I74_05785	COG2501	S4 domain
I6I74_05795	COG3695	enzyme binding
I6I74_05800	COG2076	Multidrug Resistance protein
I6I74_05820	COG3590	peptidase
I6I74_05845	COG1028	Short-chain dehydrogenase reductase Sdr
I6I74_05850	COG0277	FAD linked oxidase domain protein
I6I74_05880	COG1216	Glycosyl transferase, family 2
I6I74_05905	COG0604	alcohol dehydrogenase
I6I74_05930	COG0314	molybdopterin synthase activity
I6I74_05935	COG0521	Mo-molybdopterin cofactor biosynthetic process
I6I74_05950	COG1950	PFAM Membrane protein of
I6I74_05995	COG2239	Acts as a magnesium transporter
I6I74_06000	COG0471	metal ion transport
I6I74_06010	COG2801	Transposase and inactivated derivatives
I6I74_06010	COG3415	Transposase
I6I74_06030	COG0287	Prephenate dehydrogenase
I6I74_06055	COG2409	Drug exporters of the RND superfamily
I6I74_06060	COG0343	queuine tRNA-ribosyltransferase activity
I6I74_06070	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I6I74_06090	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
I6I74_06090	COG2755	lipolytic protein G-D-S-L family
I6I74_06105	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6I74_06135	COG3442	glutamine amidotransferase
I6I74_06140	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
I6I74_06160	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
I6I74_06170	COG0697	spore germination
I6I74_06175	COG0527	aspartate kinase activity
I6I74_06185	COG3949	Membrane
I6I74_06235	COG2851	Citrate transporter
I6I74_06270	COG0251	oxidation-reduction process
I6I74_06275	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6I74_06285	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I6I74_06295	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6I74_06300	COG0494	nUDIX hydrolase
I6I74_06310	COG0596	Alpha beta hydrolase
I6I74_06370	COG1111	helicase
I6I74_06370	COG1205	dead DEAH box helicase
I6I74_06375	COG1278	Cold shock
I6I74_06385	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I6I74_06385	COG1754	DNA topoisomerase type I activity
I6I74_06405	COG0470	DNA polymerase III
I6I74_06415	COG0318	PFAM AMP-dependent synthetase and ligase
I6I74_06430	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6I74_06445	COG1088	dTDP-glucose 4,6-dehydratase activity
I6I74_06470	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6I74_06475	COG3800	Transcriptional regulator
I6I74_06475	COG1396	sequence-specific DNA binding
I6I74_06485	COG1053	succinate dehydrogenase
I6I74_06490	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
I6I74_06500	COG2733	membrane
I6I74_06515	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
I6I74_06540	COG1854	S-ribosylhomocysteine lyase activity
I6I74_06545	COG1295	ribonuclease BN
I6I74_06550	COG0318	PFAM AMP-dependent synthetase and ligase
I6I74_06555	COG0318	PFAM AMP-dependent synthetase and ligase
I6I74_06565	COG0318	PFAM AMP-dependent synthetase and ligase
I6I74_06570	COG0438	transferase activity, transferring glycosyl groups
I6I74_06575	COG0588	phosphoglycerate mutase activity
I6I74_06580	COG2826	transposase and inactivated derivatives, IS30 family
I6I74_06585	COG5002	protein histidine kinase activity
I6I74_06590	COG0745	RESPONSE REGULATOR receiver
I6I74_06610	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
I6I74_06635	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
I6I74_06640	COG0181	hydroxymethylbilane synthase activity
I6I74_06645	COG1648	precorrin-2 dehydrogenase activity
I6I74_06645	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
I6I74_06665	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
I6I74_06680	COG2084	Dehydrogenase
I6I74_06685	COG2076	Multidrug Resistance protein
I6I74_06690	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
I6I74_06695	COG0406	alpha-ribazole phosphatase activity
I6I74_06705	COG0785	Cytochrome C biogenesis protein
I6I74_06710	COG1333	cytochrome c biogenesis protein
I6I74_06715	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I6I74_06735	COG1575	Belongs to the MenA family. Type 1 subfamily
I6I74_06740	COG1321	iron dependent repressor
I6I74_06760	COG1121	(ABC) transporter
I6I74_06765	COG0803	Belongs to the bacterial solute-binding protein 9 family
I6I74_06780	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
I6I74_06790	COG4948	Mandelate Racemase Muconate Lactonizing
I6I74_06820	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
I6I74_06820	COG0438	transferase activity, transferring glycosyl groups
I6I74_06825	COG2226	methyltransferase
I6I74_06830	COG0644	oxidoreductase
I6I74_06835	COG0142	geranyltranstransferase activity
I6I74_06855	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I6I74_06865	COG2814	Major facilitator Superfamily
I6I74_06870	COG0813	purine-nucleoside phosphorylase activity
I6I74_06890	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
I6I74_06895	COG0250	Participates in transcription elongation, termination and antitermination
I6I74_06900	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
I6I74_06905	COG0081	regulation of translation
I6I74_06910	COG0019	diaminopimelate decarboxylase activity
I6I74_06925	COG0415	Belongs to the DNA photolyase family
I6I74_06930	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
I6I74_06935	COG0222	ribosome binding
I6I74_06960	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
I6I74_06970	COG4721	ABC-type cobalt transport system, permease component
I6I74_06975	COG1122	ATPase activity
I6I74_06990	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
I6I74_06995	COG0049	tRNA binding
I6I74_07000	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
I6I74_07005	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
I6I74_07060	COG1302	Protein conserved in bacteria
I6I74_07065	COG0051	transcription antitermination factor activity, RNA binding
I6I74_07070	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
I6I74_07075	COG0088	Forms part of the polypeptide exit tunnel
I6I74_07080	COG0089	rRNA binding
I6I74_07085	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
I6I74_07090	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
I6I74_07095	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
I6I74_07100	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
I6I74_07105	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
I6I74_07110	COG0255	Belongs to the universal ribosomal protein uL29 family
I6I74_07115	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
I6I74_07120	COG2826	transposase and inactivated derivatives, IS30 family
I6I74_07135	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6I74_07140	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6I74_07145	COG1120	ATPase activity
I6I74_07170	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
I6I74_07175	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
I6I74_07180	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
I6I74_07190	COG2116	formate transmembrane transporter activity
I6I74_07195	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
I6I74_07215	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
I6I74_07220	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
I6I74_07225	COG1841	ribosomal large subunit assembly
I6I74_07230	COG0200	Binds to the 23S rRNA
I6I74_07235	COG2826	transposase and inactivated derivatives, IS30 family
I6I74_07255	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
I6I74_07260	COG0201	protein transport
I6I74_07265	COG0563	adenylate kinase activity
I6I74_07285	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
I6I74_07290	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
I6I74_07295	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
I6I74_07305	COG0203	ribosomal protein L17
I6I74_07310	COG0101	tRNA pseudouridine synthase activity
I6I74_07320	COG1404	Belongs to the peptidase S8 family
I6I74_07330	COG1674	ftsk spoiiie
I6I74_07365	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I6I74_07400	COG0488	(ABC) transporter
I6I74_07405	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
I6I74_07415	COG2985	domain, Protein
I6I74_07415	COG0569	domain protein
I6I74_07430	COG0456	acetyltransferase
I6I74_07435	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
I6I74_07460	COG0577	efflux transmembrane transporter activity
I6I74_07460	COG1136	(ABC) transporter
I6I74_07470	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
I6I74_07480	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
I6I74_07510	COG0516	GMP reductase activity
I6I74_07555	COG2011	ABC-type metal ion transport system permease component
I6I74_07565	COG1464	Belongs to the NlpA lipoprotein family
I6I74_07570	COG0587	DNA-directed DNA polymerase activity
I6I74_07585	COG3655	Transcriptional regulator
I6I74_07605	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
I6I74_07610	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
I6I74_07625	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
I6I74_07630	COG2873	o-acetylhomoserine
I6I74_07640	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6I74_07655	COG2838	Isocitrate dehydrogenase
I6I74_07660	COG2814	Major facilitator Superfamily
I6I74_07670	COG2860	membrane
I6I74_07680	COG0180	Tryptophanyl-tRNA synthetase
I6I74_07695	COG1686	Belongs to the peptidase S11 family
I6I74_07735	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
I6I74_07745	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
I6I74_07745	COG1473	amidohydrolase
I6I74_07760	COG1131	(ABC) transporter
I6I74_07765	COG2186	Transcriptional regulator
I6I74_07775	COG0577	efflux transmembrane transporter activity
I6I74_07775	COG1136	(ABC) transporter
I6I74_07785	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
I6I74_07805	COG1129	ABC transporter
I6I74_07815	COG4770	biotin carboxylase activity
I6I74_07820	COG2897	thiosulfate sulfurtransferase activity
I6I74_07825	COG0189	ligase activity
I6I74_07845	COG0424	maF-like protein
I6I74_07855	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
I6I74_07895	COG3842	ATPase activity
I6I74_07910	COG3527	Alpha-acetolactate decarboxylase
I6I74_07945	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6I74_07955	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6I74_07960	COG1129	ABC transporter
I6I74_07965	COG1609	Transcriptional regulator
I6I74_07995	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
I6I74_08000	COG0328	RNA-DNA hybrid ribonuclease activity
I6I74_08010	COG1914	H( )-stimulated, divalent metal cation uptake system
I6I74_08015	COG4336	lyase activity
I6I74_08025	COG4770	biotin carboxylase activity
I6I74_08030	COG1984	allophanate hydrolase subunit 2
I6I74_08035	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
I6I74_08045	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6I74_08045	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6I74_08045	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6I74_08065	COG0477	Major facilitator Superfamily
I6I74_08080	COG3265	gluconokinase activity
I6I74_08085	COG2610	gluconate transmembrane transporter activity
I6I74_08095	COG3842	ATPase activity
I6I74_08100	COG1653	transport
I6I74_08135	COG0814	amino acid
I6I74_08160	COG1316	TRANSCRIPTIONal
I6I74_08200	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I6I74_08215	COG0730	response to heat
I6I74_08220	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
I6I74_08220	COG1648	precorrin-2 dehydrogenase activity
I6I74_08230	COG1482	cell wall glycoprotein biosynthetic process
I6I74_08250	COG0745	RESPONSE REGULATOR receiver
I6I74_08255	COG5002	protein histidine kinase activity
I6I74_08260	COG5401	PFAM Sporulation and spore germination
I6I74_08270	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
I6I74_08275	COG0653	protein targeting
I6I74_08305	COG1162	GTPase activity
I6I74_08310	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
I6I74_08315	COG2135	peptidase activity
I6I74_08320	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
I6I74_08350	COG0513	Belongs to the DEAD box helicase family
I6I74_08375	COG0210	DNA helicase
I6I74_08380	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I6I74_08410	COG3480	Lon protease (S16) C-terminal proteolytic domain
I6I74_08440	COG0659	secondary active sulfate transmembrane transporter activity
I6I74_08460	COG4762	Protein conserved in bacteria
I6I74_08470	COG0483	inositol monophosphate 1-phosphatase activity
I6I74_08475	COG0483	inositol monophosphate 1-phosphatase activity
I6I74_08480	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
I6I74_08485	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
I6I74_08495	COG2884	Cell division ATP-binding protein ftsE
I6I74_08500	COG2177	Part of the ABC transporter FtsEX involved in
I6I74_08555	COG2801	Transposase and inactivated derivatives
I6I74_08555	COG3415	Transposase
I6I74_08565	COG1061	Type III restriction enzyme res subunit
I6I74_08580	COG1652	LysM domain
I6I74_08605	COG2252	PERMEase
I6I74_08610	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6I74_08630	COG0372	Belongs to the citrate synthase family
I6I74_08635	COG0545	Peptidyl-prolyl cis-trans isomerase
I6I74_08650	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6I74_08660	COG3757	hydrolase, family 25
I6I74_08740	COG2801	Transposase and inactivated derivatives
I6I74_08740	COG3415	Transposase
I6I74_08745	COG2801	Transposase and inactivated derivatives
I6I74_08745	COG3415	Transposase
I6I74_08755	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
I6I74_08765	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
I6I74_08770	COG1218	3'(2'),5'-bisphosphate nucleotidase
I6I74_08775	COG1201	RNA secondary structure unwinding
I6I74_08780	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
I6I74_08785	COG3304	Inner membrane component domain
I6I74_08795	COG2056	Na+-H+ antiporter family
I6I74_08800	COG1605	Chorismate mutase
I6I74_08830	COG0138	bifunctional purine biosynthesis protein purh
I6I74_08845	COG1309	transcriptional regulator
I6I74_08860	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
I6I74_08865	COG0267	Belongs to the bacterial ribosomal protein bL33 family
I6I74_08870	COG0227	Belongs to the bacterial ribosomal protein bL28 family
I6I74_08875	COG0254	rRNA binding
I6I74_08885	COG0745	RESPONSE REGULATOR receiver
I6I74_08890	COG2205	protein histidine kinase activity
I6I74_08895	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6I74_08900	COG0315	cyclic pyranopterin monophosphate synthase activity
I6I74_08900	COG0521	Mo-molybdopterin cofactor biosynthetic process
I6I74_08910	COG1970	mechanosensitive ion channel activity
I6I74_08920	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
I6I74_08925	COG1210	Utp--glucose-1-phosphate uridylyltransferase
I6I74_08935	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6I74_08945	COG0519	Catalyzes the synthesis of GMP from XMP
I6I74_08960	COG1928	C-terminal four TMM region of protein-O-mannosyltransferase
I6I74_08970	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I6I74_08990	COG0084	hydrolase, TatD family'
I6I74_08995	COG3583	domain protein
I6I74_09000	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
I6I74_09015	COG0488	(ABC) transporter
I6I74_09045	COG0561	phosphatase activity
I6I74_09050	COG1024	Enoyl-CoA hydratase
I6I74_09140	COG2985	domain, Protein
I6I74_09140	COG0569	domain protein
I6I74_09145	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
I6I74_09155	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
I6I74_09165	COG0193	aminoacyl-tRNA hydrolase activity
I6I74_09210	COG1131	(ABC) transporter
I6I74_09215	COG2197	response regulator
I6I74_09220	COG4585	Histidine kinase
I6I74_09225	COG2326	polyphosphate kinase activity
I6I74_09230	COG0179	Fumarylacetoacetate (FAA) hydrolase
I6I74_09235	COG0193	aminoacyl-tRNA hydrolase activity
I6I74_09245	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
I6I74_09250	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
I6I74_09260	COG2860	membrane
I6I74_09275	COG0531	amino acid
I6I74_09280	COG3956	TIGRFAM MazG family protein
I6I74_09290	COG0148	phosphopyruvate hydratase activity
I6I74_09330	COG3415	Transposase
I6I74_09330	COG2801	Transposase and inactivated derivatives
I6I74_09365	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
I6I74_09380	COG1072	(Pantothenic acid kinase))
I6I74_09385	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
I6I74_09405	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
I6I74_09415	COG2826	transposase and inactivated derivatives, IS30 family
I6I74_09430	COG0114	fumarate hydratase activity
I6I74_09435	COG1494	fructose-1,6-bisphosphatase
I6I74_09450	COG1722	exodeoxyribonuclease VII activity
I6I74_09470	COG1322	Protein conserved in bacteria
I6I74_09480	COG0012	GTP binding
I6I74_09485	COG0693	protein deglycase activity
I6I74_09490	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
I6I74_09505	COG1823	symporter activity
I6I74_09510	COG1525	nuclease
I6I74_09515	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
I6I74_09520	COG3383	formate dehydrogenase (NAD+) activity
I6I74_09520	COG0243	molybdopterin cofactor binding
I6I74_09525	COG0243	molybdopterin cofactor binding
I6I74_09525	COG3383	formate dehydrogenase (NAD+) activity
I6I74_09530	COG0437	4 iron, 4 sulfur cluster binding
I6I74_09575	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I6I74_09580	COG0428	transporter
I6I74_09585	COG2354	Protein conserved in bacteria
I6I74_09600	COG1217	gtp-binding protein TYPA
I6I74_09635	COG0564	pseudouridine synthase activity
I6I74_09650	COG1476	TRANSCRIPTIONal
I6I74_09660	COG1113	amino acid transport
I6I74_09670	COG1113	amino acid transport
I6I74_09675	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I6I74_09680	COG1611	Belongs to the LOG family
I6I74_09685	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
I6I74_09690	COG0463	Glycosyl transferase, family 2
I6I74_09715	COG0297	glycogen (starch) synthase activity
I6I74_09720	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
I6I74_09725	COG4122	O-methyltransferase activity
I6I74_09730	COG1595	DNA-templated transcription, initiation
I6I74_09755	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6I74_09755	COG0567	Dehydrogenase, E1 component
I6I74_09765	COG2272	Belongs to the type-B carboxylesterase lipase family
I6I74_09785	COG2814	Major facilitator Superfamily
I6I74_09795	COG0494	nUDIX hydrolase
I6I74_09800	COG3314	Sporulation integral membrane protein YlbJ
I6I74_09805	COG0010	Belongs to the arginase family
I6I74_09815	COG2986	histidine ammonia-lyase
I6I74_09820	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I6I74_09825	COG2755	lipolytic protein G-D-S-L family
I6I74_09830	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
I6I74_09835	COG1228	amidohydrolase
I6I74_09860	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6I74_09865	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
I6I74_09900	COG1668	transmembrane transport
I6I74_09905	COG4152	abc transporter atp-binding protein
I6I74_09930	COG1556	Lactate utilization protein
I6I74_09935	COG1139	Iron-sulfur cluster binding protein
I6I74_09940	COG0247	lactate metabolic process
I6I74_09945	COG0018	arginyl-trna synthetase
I6I74_09950	COG0019	diaminopimelate decarboxylase activity
I6I74_09955	COG0460	homoserine dehydrogenase
I6I74_09960	COG0083	homoserine kinase activity
I6I74_10005	COG0315	cyclic pyranopterin monophosphate synthase activity
I6I74_10015	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
I6I74_10020	COG0318	PFAM AMP-dependent synthetase and ligase
I6I74_10030	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
I6I74_10055	COG0356	it plays a direct role in the translocation of protons across the membrane
I6I74_10060	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
I6I74_10065	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
I6I74_10070	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
I6I74_10075	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
I6I74_10085	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
I6I74_10090	COG0355	proton-transporting ATP synthase activity, rotational mechanism
I6I74_10100	COG1637	Cleaves both 3' and 5' ssDNA extremities of branched DNA structures
I6I74_10115	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I6I74_10125	COG0366	Alpha amylase catalytic
I6I74_10130	COG1119	ATPase activity
I6I74_10150	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
I6I74_10175	COG0482	sulfurtransferase activity
I6I74_10200	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
I6I74_10210	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
I6I74_10235	COG0205	6-phosphofructokinase activity
I6I74_10240	COG0385	Bile acid
I6I74_10255	COG1064	alcohol dehydrogenase
I6I74_10260	COG3949	Membrane
I6I74_10265	COG0667	Aldo Keto reductase
I6I74_10275	COG0583	DNA-binding transcription factor activity
I6I74_10300	COG0129	dihydroxy-acid dehydratase activity
I6I74_10310	COG0028	Belongs to the TPP enzyme family
I6I74_10315	COG0440	acetolactate synthase activity
I6I74_10320	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
I6I74_10340	COG0473	3-isopropylmalate dehydrogenase activity
I6I74_10345	COG0179	Fumarylacetoacetate (FAA) hydrolase
I6I74_10365	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I6I74_10370	COG1121	(ABC) transporter
I6I74_10435	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
I6I74_10440	COG0066	3-isopropylmalate dehydratase activity
I6I74_10450	COG0406	alpha-ribazole phosphatase activity
I6I74_10450	COG0494	nUDIX hydrolase
I6I74_10455	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
I6I74_10460	COG1181	Belongs to the D-alanine--D-alanine ligase family
I6I74_10470	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
I6I74_10475	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
I6I74_10480	COG1461	Dihydroxyacetone kinase
I6I74_10485	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
I6I74_10490	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6I74_10495	COG0742	ribosomal rna small subunit methyltransferase
I6I74_10500	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
I6I74_10515	COG0765	amino acid transport
I6I74_10520	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6I74_10530	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
I6I74_10560	COG2226	methyltransferase
I6I74_10565	COG0539	negative regulation of cytoplasmic translation
I6I74_10575	COG0237	dephospho-CoA kinase activity
I6I74_10605	COG3973	AAA domain
I6I74_10635	COG0291	Belongs to the bacterial ribosomal protein bL35 family
I6I74_10640	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
I6I74_10650	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6I74_10660	COG0072	phenylalanine-tRNA ligase activity
I6I74_10660	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6I74_10665	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I6I74_10670	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
I6I74_10675	COG1438	arginine binding
I6I74_10680	COG0137	argininosuccinate synthase activity
I6I74_10685	COG0165	Argininosuccinate lyase
I6I74_10700	COG2835	tetraacyldisaccharide 4'-kinase activity
I6I74_10740	COG0647	UMP catabolic process
I6I74_10755	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
I6I74_10775	COG0494	nUDIX hydrolase
I6I74_10780	COG4974	Belongs to the 'phage' integrase family
I6I74_10805	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
I6I74_10815	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
I6I74_10820	COG1160	GTP binding
I6I74_10825	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
I6I74_10835	COG1132	(ABC) transporter
I6I74_10840	COG1132	(ABC) transporter
I6I74_10875	COG2197	response regulator
I6I74_10880	COG4585	Histidine kinase
I6I74_10890	COG1131	(ABC) transporter
I6I74_10905	COG3012	SEC-C Motif Domain Protein
I6I74_10915	COG0653	protein targeting
I6I74_10920	COG1716	ATPase activity
I6I74_10950	COG0513	Belongs to the DEAD box helicase family
I6I74_10955	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
I6I74_10965	COG3268	Saccharopine dehydrogenase
I6I74_10970	COG0598	Magnesium transport protein CorA
I6I74_10980	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
I6I74_10980	COG0352	thiamine-phosphate diphosphorylase activity
I6I74_10980	COG0351	phosphomethylpyrimidine kinase
I6I74_10985	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
I6I74_10985	COG0352	thiamine-phosphate diphosphorylase activity
I6I74_10985	COG0351	phosphomethylpyrimidine kinase
I6I74_11005	COG2837	iron assimilation
I6I74_11030	COG0463	Glycosyl transferase, family 2
I6I74_11050	COG0300	oxidoreductase activity
I6I74_11065	COG0805	protein transport
I6I74_11070	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I6I74_11085	COG0638	Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine
I6I74_11095	COG4122	O-methyltransferase activity
I6I74_11100	COG1222	aaa ATPase
I6I74_11110	COG1362	aminopeptidase activity
I6I74_11120	COG2759	Belongs to the formate--tetrahydrofolate ligase family
I6I74_11125	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
I6I74_11130	COG1027	Aspartate ammonia-lyase
I6I74_11135	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
I6I74_11155	COG0215	cysteine-tRNA ligase activity
I6I74_11170	COG0167	dihydroorotate dehydrogenase activity
I6I74_11180	COG1881	PFAM PEBP family protein
I6I74_11215	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
I6I74_11220	COG0791	NLP P60 protein
I6I74_11220	COG3883	PFAM NLP P60 protein
I6I74_11230	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
I6I74_11265	COG3830	Belongs to the UPF0237 family
I6I74_11270	COG2848	UPF0210 protein
I6I74_11280	COG0488	(ABC) transporter
I6I74_11285	COG2151	metal-sulfur cluster biosynthetic enzyme
I6I74_11290	COG0822	iron-sulfur transferase activity
I6I74_11300	COG0396	ATPase activity
I6I74_11355	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
I6I74_11375	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
I6I74_11380	COG0149	triose-phosphate isomerase activity
I6I74_11385	COG0126	phosphoglycerate kinase activity
I6I74_11390	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
I6I74_11395	COG1620	l-lactate permease
I6I74_11400	COG1481	regulation of sporulation
I6I74_11405	COG0391	Required for morphogenesis under gluconeogenic growth conditions
I6I74_11410	COG1660	Displays ATPase and GTPase activities
I6I74_11415	COG0322	excinuclease ABC activity
I6I74_11425	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
I6I74_11455	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
I6I74_11460	COG0242	peptide deformylase activity
I6I74_11470	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
I6I74_11480	COG1758	RNA polymerase activity
I6I74_11495	COG0284	orotidine-5'-phosphate decarboxylase activity
I6I74_11500	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
I6I74_11510	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
I6I74_11515	COG0540	Belongs to the ATCase OTCase family
I6I74_11540	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
I6I74_11545	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
I6I74_11555	COG0006	proline dipeptidase activity
I6I74_11560	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
I6I74_11570	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
I6I74_11575	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
I6I74_11585	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
I6I74_11595	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA