locus-tag	class	description
CULC0211_00020	COG0592	DNA-directed DNA polymerase activity
CULC0211_00050	COG0187	DNA topoisomerase II activity
CULC0211_00090	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CULC0211_00260	COG1518	maintenance of DNA repeat elements
CULC0211_00350	COG1120	ATPase activity
CULC0211_00360	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CULC0211_00370	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CULC0211_00380	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CULC0211_00400	COG0515	serine threonine protein kinase
CULC0211_00400	COG2815	serine threonine protein kinase
CULC0211_00410	COG0515	serine threonine protein kinase
CULC0211_00420	COG0768	penicillin binding
CULC0211_00460	COG1716	ATPase activity
CULC0211_00460	COG1716	ATPase activity
CULC0211_00530	COG2897	thiosulfate sulfurtransferase activity
CULC0211_00570	COG1120	ATPase activity
CULC0211_00580	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CULC0211_00590	COG2239	Acts as a magnesium transporter
CULC0211_00600	COG0366	Alpha amylase catalytic
CULC0211_00640	COG2197	response regulator
CULC0211_00770	COG1125	glycine betaine transport
CULC0211_00770	COG0517	IMP dehydrogenase activity
CULC0211_00800	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CULC0211_00840	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
CULC0211_00870	COG3757	hydrolase, family 25
CULC0211_00870	COG3409	Peptidoglycan-binding domain 1 protein
CULC0211_01000	COG1518	maintenance of DNA repeat elements
CULC0211_01000	COG1468	defense response to virus
CULC0211_01020	COG1201	RNA secondary structure unwinding
CULC0211_01080	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
CULC0211_01130	COG1846	Transcriptional regulator
CULC0211_01160	COG3180	Ammonia monooxygenase
CULC0211_01180	COG0730	response to heat
CULC0211_01200	COG3037	sugar-specific permease SgaT UlaA
CULC0211_01210	COG1643	Atp-dependent helicase
CULC0211_01220	COG0110	maltose O-acetyltransferase activity
CULC0211_01230	COG3145	DNA-N1-methyladenine dioxygenase activity
CULC0211_01240	COG0519	Catalyzes the synthesis of GMP from XMP
CULC0211_01260	COG1280	lysine exporter protein (LysE YggA)
CULC0211_01270	COG0393	Putative heavy-metal-binding
CULC0211_01280	COG2501	S4 domain
CULC0211_01320	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
CULC0211_01330	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
CULC0211_01350	COG3590	peptidase
CULC0211_01410	COG1028	Short-chain dehydrogenase reductase Sdr
CULC0211_01420	COG0277	FAD linked oxidase domain protein
CULC0211_01480	COG1216	Glycosyl transferase, family 2
CULC0211_01490	COG0803	Belongs to the bacterial solute-binding protein 9 family
CULC0211_01500	COG1121	(ABC) transporter
CULC0211_01510	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CULC0211_01520	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CULC0211_01530	COG0803	Belongs to the bacterial solute-binding protein 9 family
CULC0211_01580	COG0604	alcohol dehydrogenase
CULC0211_01600	COG0471	metal ion transport
CULC0211_01620	COG1263	PTS System
CULC0211_01620	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CULC0211_01630	COG1263	PTS System
CULC0211_01630	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CULC0211_01630	COG2190	(PTS) system
CULC0211_01650	COG4974	Belongs to the 'phage' integrase family
CULC0211_02100	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CULC0211_02140	COG0287	Prephenate dehydrogenase
CULC0211_02160	COG0590	tRNA wobble adenosine to inosine editing
CULC0211_02170	COG2409	Drug exporters of the RND superfamily
CULC0211_02180	COG0343	queuine tRNA-ribosyltransferase activity
CULC0211_02200	COG2610	gluconate transmembrane transporter activity
CULC0211_02210	COG3265	gluconokinase activity
CULC0211_02220	COG1063	alcohol dehydrogenase
CULC0211_02230	COG1028	Short-chain dehydrogenase reductase Sdr
CULC0211_02240	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CULC0211_02290	COG2610	gluconate transmembrane transporter activity
CULC0211_02300	COG2084	Dehydrogenase
CULC0211_02320	COG2186	Transcriptional regulator
CULC0211_02330	COG0179	Fumarylacetoacetate (FAA) hydrolase
CULC0211_02360	COG3442	glutamine amidotransferase
CULC0211_02370	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
CULC0211_02400	COG0778	Nitroreductase
CULC0211_02420	COG2390	Transcriptional regulator
CULC0211_02430	COG0813	purine-nucleoside phosphorylase activity
CULC0211_02440	COG2814	Major facilitator Superfamily
CULC0211_02460	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CULC0211_02480	COG4932	domain protein
CULC0211_02480	COG2931	calcium- and calmodulin-responsive adenylate cyclase activity
CULC0211_02480	COG3266	domain, Protein
CULC0211_02500	COG0697	spore germination
CULC0211_02510	COG1131	(ABC) transporter
CULC0211_02530	COG0527	aspartate kinase activity
CULC0211_02560	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
CULC0211_02700	COG1840	ABC-type Fe3 transport system, periplasmic component
CULC0211_02710	COG2271	Major facilitator Superfamily
CULC0211_02730	COG3852	Histidine kinase
CULC0211_02790	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CULC0211_02790	COG2111	Na H antiporter
CULC0211_02840	COG4152	abc transporter atp-binding protein
CULC0211_02870	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CULC0211_02920	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CULC0211_02960	COG0494	nUDIX hydrolase
CULC0211_03100	COG1111	helicase
CULC0211_03100	COG1205	dead DEAH box helicase
CULC0211_03120	COG1754	DNA topoisomerase type I activity
CULC0211_03120	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CULC0211_03130	COG1297	OPT oligopeptide transporter protein
CULC0211_03150	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
CULC0211_03170	COG0318	PFAM AMP-dependent synthetase and ligase
CULC0211_03210	COG1088	dTDP-glucose 4,6-dehydratase activity
CULC0211_03230	COG1505	serine-type exopeptidase activity
CULC0211_03260	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CULC0211_03270	COG3800	Transcriptional regulator
CULC0211_03270	COG1396	sequence-specific DNA binding
CULC0211_03290	COG1053	succinate dehydrogenase
CULC0211_03300	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
CULC0211_03320	COG2733	membrane
CULC0211_03340	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
CULC0211_03360	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
CULC0211_03380	COG1882	Formate acetyltransferase
CULC0211_03420	COG0318	PFAM AMP-dependent synthetase and ligase
CULC0211_03450	COG5002	protein histidine kinase activity
CULC0211_03460	COG0745	RESPONSE REGULATOR receiver
CULC0211_03500	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
CULC0211_03540	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CULC0211_03540	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
CULC0211_03560	COG0560	Phosphoserine phosphatase
CULC0211_03600	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CULC0211_03600	COG1648	precorrin-2 dehydrogenase activity
CULC0211_03630	COG2217	Heavy metal translocating P-type atpase
CULC0211_03680	COG0406	alpha-ribazole phosphatase activity
CULC0211_03700	COG0785	Cytochrome C biogenesis protein
CULC0211_03730	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CULC0211_03790	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
CULC0211_03810	COG3069	C4-dicarboxylate transmembrane transporter activity
CULC0211_03820	COG4948	Mandelate Racemase Muconate Lactonizing
CULC0211_03850	COG0438	transferase activity, transferring glycosyl groups
CULC0211_03850	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CULC0211_03870	COG0039	L-malate dehydrogenase activity
CULC0211_03880	COG0644	oxidoreductase
CULC0211_03900	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CULC0211_03960	COG1902	pentaerythritol trinitrate reductase activity
CULC0211_04020	COG1121	(ABC) transporter
CULC0211_04030	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CULC0211_04120	COG2197	response regulator
CULC0211_04160	COG1131	(ABC) transporter
CULC0211_04190	COG0701	Predicted permease
CULC0211_04340	COG1302	Protein conserved in bacteria
CULC0211_04350	COG0051	transcription antitermination factor activity, RNA binding
CULC0211_04460	COG0747	negative chemotaxis
CULC0211_04530	COG0814	amino acid
CULC0211_04540	COG1760	l-serine dehydratase
CULC0211_04550	COG0252	asparaginase activity
CULC0211_04570	COG0671	phosphoesterase, PA-phosphatase related
CULC0211_04660	COG1175	transmembrane transport
CULC0211_04670	COG3833	ABC-type maltose transport systems, permease component
CULC0211_04710	COG3842	ATPase activity
CULC0211_04720	COG0201	protein transport
CULC0211_04730	COG0563	adenylate kinase activity
CULC0211_04820	COG0203	ribosomal protein L17
CULC0211_04860	COG1404	Belongs to the peptidase S8 family
CULC0211_04890	COG1674	ftsk spoiiie
CULC0211_05620	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CULC0211_05670	COG0456	acetyltransferase
CULC0211_05750	COG0516	GMP reductase activity
CULC0211_05840	COG2011	ABC-type metal ion transport system permease component
CULC0211_05860	COG1464	Belongs to the NlpA lipoprotein family
CULC0211_05870	COG1464	Belongs to the NlpA lipoprotein family
CULC0211_05900	COG0803	Belongs to the bacterial solute-binding protein 9 family
CULC0211_05910	COG1121	(ABC) transporter
CULC0211_05930	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CULC0211_05930	COG1321	iron dependent repressor
CULC0211_05950	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
CULC0211_06040	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CULC0211_06050	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
CULC0211_06070	COG2873	o-acetylhomoserine
CULC0211_06080	COG2838	Isocitrate dehydrogenase
CULC0211_06090	COG2814	Major facilitator Superfamily
CULC0211_06100	COG0789	Transcriptional regulator
CULC0211_06100	COG4978	Transcriptional regulator
CULC0211_06140	COG0180	Tryptophanyl-tRNA synthetase
CULC0211_06150	COG1295	ribonuclease BN
CULC0211_06160	COG1686	Belongs to the peptidase S11 family
CULC0211_06230	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CULC0211_06240	COG1473	amidohydrolase
CULC0211_06240	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
CULC0211_06260	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
CULC0211_06270	COG2814	Major facilitator Superfamily
CULC0211_06290	COG4770	biotin carboxylase activity
CULC0211_06300	COG2897	thiosulfate sulfurtransferase activity
CULC0211_06310	COG0189	ligase activity
CULC0211_06320	COG2755	lipolytic protein G-D-S-L family
CULC0211_06320	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
CULC0211_06340	COG0424	maF-like protein
CULC0211_06350	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CULC0211_06360	COG1609	Transcriptional regulator
CULC0211_06380	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CULC0211_06390	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CULC0211_06400	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
CULC0211_06400	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
CULC0211_06440	COG4555	ABC transporter
CULC0211_06500	COG1120	ATPase activity
CULC0211_06560	COG1316	TRANSCRIPTIONal
CULC0211_06580	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
CULC0211_06640	COG1482	cell wall glycoprotein biosynthetic process
CULC0211_06700	COG0745	RESPONSE REGULATOR receiver
CULC0211_06710	COG5002	protein histidine kinase activity
CULC0211_06730	COG1040	competence protein
CULC0211_06740	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
CULC0211_06810	COG1162	GTPase activity
CULC0211_06830	COG2135	peptidase activity
CULC0211_06840	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
CULC0211_06910	COG0513	Belongs to the DEAD box helicase family
CULC0211_06960	COG0210	DNA helicase
CULC0211_06980	COG2816	NAD+ diphosphatase activity
CULC0211_07030	COG3480	Lon protease (S16) C-terminal proteolytic domain
CULC0211_07200	COG0483	inositol monophosphate 1-phosphatase activity
CULC0211_07210	COG0483	inositol monophosphate 1-phosphatase activity
CULC0211_07240	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
CULC0211_07250	COG2884	Cell division ATP-binding protein ftsE
CULC0211_07260	COG2177	Part of the ABC transporter FtsEX involved in
CULC0211_07280	COG0288	reversible hydration of carbon dioxide
CULC0211_07390	COG1652	LysM domain
CULC0211_07400	COG1278	Cold shock
CULC0211_07440	COG2252	PERMEase
CULC0211_07490	COG0372	Belongs to the citrate synthase family
CULC0211_07500	COG0545	Peptidyl-prolyl cis-trans isomerase
CULC0211_07540	COG0656	L-ascorbic acid biosynthetic process
CULC0211_07550	COG1024	Enoyl-CoA hydratase
CULC0211_07570	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CULC0211_07590	COG3757	hydrolase, family 25
CULC0211_07620	COG0534	Mate efflux family protein
CULC0211_07630	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CULC0211_07640	COG0019	diaminopimelate decarboxylase activity
CULC0211_07670	COG4166	transmembrane transport
CULC0211_07690	COG4171	peptide transport system, permease
CULC0211_07780	COG1218	3'(2'),5'-bisphosphate nucleotidase
CULC0211_07790	COG1201	RNA secondary structure unwinding
CULC0211_07810	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
CULC0211_07850	COG1605	Chorismate mutase
CULC0211_07870	COG0739	heme binding
CULC0211_07910	COG1126	abc transporter atp-binding protein
CULC0211_07920	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CULC0211_07930	COG0765	amino acid transport
CULC0211_07940	COG0765	amino acid transport
CULC0211_08020	COG0254	rRNA binding
CULC0211_08040	COG0745	RESPONSE REGULATOR receiver
CULC0211_08050	COG2205	protein histidine kinase activity
CULC0211_08060	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CULC0211_08070	COG0521	Mo-molybdopterin cofactor biosynthetic process
CULC0211_08070	COG0315	cyclic pyranopterin monophosphate synthase activity
CULC0211_08090	COG1970	mechanosensitive ion channel activity
CULC0211_08120	COG1210	Utp--glucose-1-phosphate uridylyltransferase
CULC0211_08160	COG2259	Doxx family
CULC0211_08180	COG1928	C-terminal four TMM region of protein-O-mannosyltransferase
CULC0211_08190	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CULC0211_08200	COG3949	Membrane
CULC0211_08230	COG0084	hydrolase, TatD family'
CULC0211_08240	COG3583	domain protein
CULC0211_08270	COG0488	(ABC) transporter
CULC0211_08320	COG2326	polyphosphate kinase activity
CULC0211_08400	COG0596	Alpha beta hydrolase
CULC0211_08410	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
CULC0211_08430	COG0193	aminoacyl-tRNA hydrolase activity
CULC0211_08440	COG2070	2-Nitropropane dioxygenase
CULC0211_08480	COG1523	belongs to the glycosyl hydrolase 13 family
CULC0211_08490	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CULC0211_08500	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
CULC0211_08510	COG2132	Multicopper oxidase
CULC0211_08530	COG1309	transcriptional regulator
CULC0211_08550	COG0531	amino acid
CULC0211_08560	COG3956	TIGRFAM MazG family protein
CULC0211_08680	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
CULC0211_08820	COG0114	fumarate hydratase activity
CULC0211_08830	COG1494	fructose-1,6-bisphosphatase
CULC0211_08900	COG0012	GTP binding
CULC0211_08920	COG2824	Alkylphosphonate utilization operon protein PhnA
CULC0211_08930	COG1132	(ABC) transporter
CULC0211_08940	COG1132	(ABC) transporter
CULC0211_08950	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CULC0211_08960	COG2354	Protein conserved in bacteria
CULC0211_08980	COG4721	ABC-type cobalt transport system, permease component
CULC0211_08990	COG4172	Belongs to the ABC transporter superfamily
CULC0211_09010	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
CULC0211_09020	COG1051	belongs to the nudix hydrolase family
CULC0211_09030	COG4166	transmembrane transport
CULC0211_09040	COG0601	transmembrane transport
CULC0211_09080	COG1136	(ABC) transporter
CULC0211_09100	COG5640	endopeptidase activity
CULC0211_09220	COG1113	amino acid transport
CULC0211_09240	COG1113	amino acid transport
CULC0211_09260	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CULC0211_09280	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
CULC0211_09290	COG0463	Glycosyl transferase, family 2
CULC0211_09340	COG3527	Alpha-acetolactate decarboxylase
CULC0211_09350	COG0297	glycogen (starch) synthase activity
CULC0211_09370	COG4122	O-methyltransferase activity
CULC0211_09380	COG1595	DNA-templated transcription, initiation
CULC0211_09430	COG2239	Acts as a magnesium transporter
CULC0211_09450	COG0508	dehydrogenase complex catalyzes the overall conversion of
CULC0211_09450	COG0567	Dehydrogenase, E1 component
CULC0211_09460	COG1132	(ABC) transporter
CULC0211_09480	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CULC0211_09490	COG2272	Belongs to the type-B carboxylesterase lipase family
CULC0211_09540	COG2017	converts alpha-aldose to the beta-anomer
CULC0211_09580	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
CULC0211_09630	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CULC0211_09640	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CULC0211_09690	COG1846	Transcriptional regulator
CULC0211_09720	COG1349	DNA-binding transcription factor activity
CULC0211_09760	COG1556	Lactate utilization protein
CULC0211_09770	COG1139	Iron-sulfur cluster binding protein
CULC0211_09780	COG0247	lactate metabolic process
CULC0211_09790	COG1620	l-lactate permease
CULC0211_09810	COG0019	diaminopimelate decarboxylase activity
CULC0211_09820	COG0460	homoserine dehydrogenase
CULC0211_09920	COG0356	it plays a direct role in the translocation of protons across the membrane
CULC0211_09930	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CULC0211_09940	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
CULC0211_10070	COG1119	ATPase activity
CULC0211_10110	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
CULC0211_10240	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CULC0211_10250	COG1120	ATPase activity
CULC0211_10290	COG0205	6-phosphofructokinase activity
CULC0211_10320	COG0667	Aldo Keto reductase
CULC0211_10340	COG0583	DNA-binding transcription factor activity
CULC0211_10350	COG0435	Glutathione S-transferase
CULC0211_10400	COG0668	transmembrane transport
CULC0211_10410	COG0028	Belongs to the TPP enzyme family
CULC0211_10490	COG0473	3-isopropylmalate dehydrogenase activity
CULC0211_10530	COG0179	Fumarylacetoacetate (FAA) hydrolase
CULC0211_10630	COG3586	endonuclease activity
CULC0211_10650	COG0601	transmembrane transport
CULC0211_10660	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CULC0211_10670	COG0444	Belongs to the ABC transporter superfamily
CULC0211_10690	COG0747	negative chemotaxis
CULC0211_10790	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
CULC0211_10800	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
CULC0211_10810	COG1461	Dihydroxyacetone kinase
CULC0211_10830	COG0511	ligase activity, forming carbon-carbon bonds
CULC0211_10840	COG0742	ribosomal rna small subunit methyltransferase
CULC0211_10890	COG0765	amino acid transport
CULC0211_10950	COG0539	negative regulation of cytoplasmic translation
CULC0211_11010	COG3973	AAA domain
CULC0211_11030	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CULC0211_11060	COG0291	Belongs to the bacterial ribosomal protein bL35 family
CULC0211_11090	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CULC0211_11150	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CULC0211_11160	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
CULC0211_11190	COG0165	Argininosuccinate lyase
CULC0211_11200	COG2835	tetraacyldisaccharide 4'-kinase activity
CULC0211_11230	COG0647	UMP catabolic process
CULC0211_11310	COG4974	Belongs to the 'phage' integrase family
CULC0211_11350	COG3104	oligopeptide transport
CULC0211_11360	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CULC0211_11380	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
CULC0211_11410	COG1160	GTP binding
CULC0211_11420	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
CULC0211_11440	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
CULC0211_11450	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
CULC0211_11460	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
CULC0211_11480	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CULC0211_11490	COG1120	ATPase activity
CULC0211_11500	COG4264	IucA IucC family
CULC0211_11530	COG3012	SEC-C Motif Domain Protein
CULC0211_11640	COG1253	flavin adenine dinucleotide binding
CULC0211_11650	COG0513	Belongs to the DEAD box helicase family
CULC0211_11660	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
CULC0211_11680	COG0598	Magnesium transport protein CorA
CULC0211_11700	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
CULC0211_11750	COG0477	Major facilitator Superfamily
CULC0211_11760	COG0277	FAD linked oxidase domain protein
CULC0211_11820	COG0463	Glycosyl transferase, family 2
CULC0211_11930	COG0300	oxidoreductase activity
CULC0211_11960	COG0805	protein transport
CULC0211_11980	COG2378	regulation of single-species biofilm formation
CULC0211_12020	COG4122	O-methyltransferase activity
CULC0211_12050	COG1362	aminopeptidase activity
CULC0211_12090	COG1027	Aspartate ammonia-lyase
CULC0211_12100	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
CULC0211_12130	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CULC0211_12140	COG0646	methionine synthase
CULC0211_12140	COG1410	methionine synthase
CULC0211_12180	COG0667	Aldo Keto reductase
CULC0211_12200	COG0167	dihydroorotate dehydrogenase activity
CULC0211_12230	COG1881	PFAM PEBP family protein
CULC0211_12250	COG1461	Dihydroxyacetone kinase
CULC0211_12260	COG2376	Dihydroxyacetone kinase
CULC0211_12400	COG3883	PFAM NLP P60 protein
CULC0211_12400	COG0791	NLP P60 protein
CULC0211_12460	COG2848	UPF0210 protein
CULC0211_12480	COG4932	domain protein
CULC0211_12480	COG1388	LysM domain
CULC0211_12690	COG0740	serine-type endopeptidase activity
CULC0211_12820	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CULC0211_12820	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CULC0211_12960	COG4974	Belongs to the 'phage' integrase family
CULC0211_12970	COG0488	(ABC) transporter
CULC0211_12980	COG2151	metal-sulfur cluster biosynthetic enzyme
CULC0211_12990	COG0822	iron-sulfur transferase activity
CULC0211_13010	COG0396	ATPase activity
CULC0211_13100	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
CULC0211_13110	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
CULC0211_13150	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CULC0211_13190	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
CULC0211_13210	COG0391	Required for morphogenesis under gluconeogenic growth conditions
CULC0211_13230	COG0322	excinuclease ABC activity
CULC0211_13320	COG0242	peptide deformylase activity
CULC0211_13400	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
CULC0211_13420	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
CULC0211_13440	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
CULC0211_13450	COG1090	epimerase
CULC0211_13500	COG0006	proline dipeptidase activity
CULC0211_13510	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
CULC0211_13520	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
CULC0211_13540	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
CULC0211_13560	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CULC0211_13580	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
CULC0211_13690	COG1760	l-serine dehydratase
CULC0211_13710	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CULC0211_13720	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
CULC0211_13750	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CULC0211_13770	COG0747	negative chemotaxis
CULC0211_13780	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CULC0211_13790	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CULC0211_13830	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
CULC0211_13850	COG1946	Acyl-CoA thioesterase
CULC0211_13880	COG0156	8-amino-7-oxononanoate synthase activity
CULC0211_13900	COG0438	transferase activity, transferring glycosyl groups
CULC0211_13910	COG1560	Kdo2-lipid A biosynthetic process
CULC0211_13950	COG2837	iron assimilation
CULC0211_14010	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CULC0211_14260	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CULC0211_14270	COG0450	alkyl hydroperoxide reductase
CULC0211_14300	COG1643	Atp-dependent helicase
CULC0211_14340	COG1349	DNA-binding transcription factor activity
CULC0211_14350	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CULC0211_14360	COG1349	DNA-binding transcription factor activity
CULC0211_14380	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
CULC0211_14380	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CULC0211_14380	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CULC0211_14390	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CULC0211_14400	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CULC0211_14430	COG2233	PERMEase
CULC0211_14440	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
CULC0211_14470	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
CULC0211_14500	COG1196	nuclear chromosome segregation
CULC0211_14540	COG2137	regulation of response to DNA damage stimulus
CULC0211_14550	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
CULC0211_14560	COG1268	BioY protein
CULC0211_14570	COG1122	ATPase activity
CULC0211_14600	COG1396	sequence-specific DNA binding
CULC0211_14610	COG1058	Belongs to the CinA family
CULC0211_14610	COG1546	Belongs to the CinA family
CULC0211_14640	COG0861	Integral membrane protein TerC family
CULC0211_14650	COG1674	ftsk spoiiie
CULC0211_14670	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
CULC0211_14750	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
CULC0211_14780	COG0534	Mate efflux family protein
CULC0211_14870	COG3022	response to hydroperoxide
CULC0211_14880	COG1648	precorrin-2 dehydrogenase activity
CULC0211_14880	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CULC0211_14890	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
CULC0211_14900	COG0523	cobalamin synthesis protein
CULC0211_14910	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CULC0211_14910	COG2169	Transcriptional regulator
CULC0211_15020	COG0768	penicillin binding
CULC0211_15040	COG0750	zinc metalloprotease
CULC0211_15170	COG4974	Belongs to the 'phage' integrase family
CULC0211_15190	COG0606	chelatase, subunit chli
CULC0211_15200	COG0792	nuclease activity
CULC0211_15220	COG0352	thiamine-phosphate diphosphorylase activity
CULC0211_15250	COG2022	thiamine diphosphate biosynthetic process
CULC0211_15260	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
CULC0211_15270	COG0352	thiamine-phosphate diphosphorylase activity
CULC0211_15270	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
CULC0211_15270	COG0351	phosphomethylpyrimidine kinase
CULC0211_15300	COG0681	Belongs to the peptidase S26 family
CULC0211_15330	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CULC0211_15330	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CULC0211_15330	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CULC0211_15350	COG0336	Belongs to the RNA methyltransferase TrmD family
CULC0211_15360	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
CULC0211_15400	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
CULC0211_15450	COG1254	Belongs to the acylphosphatase family
CULC0211_15460	COG1115	amino acid carrier protein
CULC0211_15520	COG0686	Belongs to the AlaDH PNT family
CULC0211_15530	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
CULC0211_15540	COG1929	Belongs to the glycerate kinase type-1 family
CULC0211_15570	COG1473	amidohydrolase
CULC0211_15580	COG0058	SHG alpha-glucan phosphorylase activity
CULC0211_15600	COG0469	pyruvate kinase activity
CULC0211_15620	COG0134	indole-3-glycerol-phosphate synthase activity
CULC0211_15660	COG0483	inositol monophosphate 1-phosphatase activity
CULC0211_15790	COG2176	DNA-directed DNA polymerase activity
CULC0211_15850	COG1739	Uncharacterized protein family UPF0029
CULC0211_15860	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CULC0211_15910	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
CULC0211_15940	COG0252	asparaginase activity
CULC0211_15980	COG3599	regulation of cell shape
CULC0211_16000	COG1799	cell septum assembly
CULC0211_16020	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
CULC0211_16030	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
CULC0211_16040	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CULC0211_16100	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CULC0211_16110	COG0768	penicillin binding
CULC0211_16220	COG0515	serine threonine protein kinase
CULC0211_16220	COG2815	serine threonine protein kinase
CULC0211_16230	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
CULC0211_16270	COG1940	carbohydrate kinase activity
CULC0211_16280	COG0438	transferase activity, transferring glycosyl groups
CULC0211_16300	COG0791	NLP P60 protein
CULC0211_16410	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
CULC0211_16430	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CULC0211_16460	COG0508	dehydrogenase complex catalyzes the overall conversion of
CULC0211_16470	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CULC0211_16470	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CULC0211_16480	COG0404	The glycine cleavage system catalyzes the degradation of glycine
CULC0211_16490	COG0509	glycine decarboxylation via glycine cleavage system
CULC0211_16530	COG1120	ATPase activity
CULC0211_16540	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CULC0211_16550	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CULC0211_16600	COG0174	glutamine synthetase
CULC0211_16630	COG3547	Transposase (IS116 IS110 IS902 family)
CULC0211_16670	COG3237	CsbD-like
CULC0211_16680	COG2056	Na+-H+ antiporter family
CULC0211_16710	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
CULC0211_16770	COG0174	glutamine synthetase
CULC0211_16820	COG0557	exoribonuclease II activity
CULC0211_16830	COG0406	alpha-ribazole phosphatase activity
CULC0211_16830	COG0328	RNA-DNA hybrid ribonuclease activity
CULC0211_16850	COG3323	Protein of unknown function (DUF1653)
CULC0211_16850	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
CULC0211_16910	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
CULC0211_16930	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
CULC0211_16940	COG0596	Alpha beta hydrolase
CULC0211_16990	COG2860	membrane
CULC0211_17110	COG0423	glycine-tRNA ligase activity
CULC0211_17160	COG1381	Involved in DNA repair and RecF pathway recombination
CULC0211_17270	COG1022	Amp-dependent synthetase and ligase
CULC0211_17350	COG1132	(ABC) transporter
CULC0211_17360	COG1114	Component of the transport system for branched-chain amino acids
CULC0211_17370	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CULC0211_17390	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CULC0211_17420	COG0747	negative chemotaxis
CULC0211_17430	COG0601	transmembrane transport
CULC0211_17440	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CULC0211_17450	COG4172	Belongs to the ABC transporter superfamily
CULC0211_17470	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
CULC0211_17480	COG2391	methyltransferase activity
CULC0211_17490	COG1136	(ABC) transporter
CULC0211_17490	COG0577	efflux transmembrane transporter activity
CULC0211_17530	COG4172	Belongs to the ABC transporter superfamily
CULC0211_17540	COG1116	anion transmembrane transporter activity
CULC0211_17590	COG1280	lysine exporter protein (LysE YggA)
CULC0211_17640	COG1307	EDD domain protein, DegV family
CULC0211_17650	COG0406	alpha-ribazole phosphatase activity
CULC0211_17670	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
CULC0211_17700	COG2985	domain, Protein
CULC0211_17700	COG0569	domain protein
CULC0211_17760	COG1530	ribonuclease E activity
CULC0211_17790	COG2423	ornithine cyclodeaminase activity
CULC0211_17810	COG0285	dihydrofolate synthase activity
CULC0211_17890	COG0544	peptidyl-prolyl cis-trans isomerase activity
CULC0211_17940	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
CULC0211_17960	COG0668	transmembrane transport
CULC0211_18120	COG1131	(ABC) transporter
CULC0211_18130	COG3336	cytochrome c oxidase
CULC0211_18140	COG1966	Carbon starvation protein
CULC0211_18180	COG0604	alcohol dehydrogenase
CULC0211_18190	COG4221	oxidoreductase activity
CULC0211_18220	COG1376	ErfK ybiS ycfS ynhG family protein
CULC0211_18230	COG2130	NADP-dependent
CULC0211_18240	COG1335	isochorismatase
CULC0211_18330	COG2197	response regulator
CULC0211_18350	COG0726	polysaccharide deacetylase
CULC0211_18420	COG1234	tRNA 3'-trailer cleavage
CULC0211_18470	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
CULC0211_18540	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CULC0211_18560	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CULC0211_18600	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
CULC0211_18680	COG0640	Transcriptional regulator
CULC0211_18690	COG2217	Heavy metal translocating P-type atpase
CULC0211_18720	COG0033	Phosphoglucomutase
CULC0211_18750	COG1136	(ABC) transporter
CULC0211_18750	COG0577	efflux transmembrane transporter activity
CULC0211_18760	COG1136	(ABC) transporter
CULC0211_18760	COG0577	efflux transmembrane transporter activity
CULC0211_18790	COG2197	response regulator
CULC0211_18810	COG1045	serine acetyltransferase
CULC0211_18830	COG0371	Dehydrogenase
CULC0211_18840	COG1271	oxidase subunit
CULC0211_18850	COG1294	oxidase, subunit
CULC0211_18860	COG4988	ABC transporter
CULC0211_18870	COG4988	ABC transporter
CULC0211_18920	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CULC0211_18980	COG1597	lipid kinase activity
CULC0211_19010	COG0354	folic acid binding
CULC0211_19060	COG1780	Probably involved in ribonucleotide reductase function
CULC0211_19070	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CULC0211_19090	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CULC0211_19100	COG0047	phosphoribosylformylglycinamidine synthase activity
CULC0211_19110	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CULC0211_19120	COG0386	Belongs to the glutathione peroxidase family
CULC0211_19160	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
CULC0211_19170	COG0569	domain protein
CULC0211_19180	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CULC0211_19190	COG0151	Belongs to the GarS family
CULC0211_19200	COG0537	adenosine 5'-monophosphoramidase activity
CULC0211_19220	COG2205	protein histidine kinase activity
CULC0211_19230	COG0745	RESPONSE REGULATOR receiver
CULC0211_19240	COG0477	Major facilitator Superfamily
CULC0211_19290	COG0028	Belongs to the TPP enzyme family
CULC0211_19380	COG1609	Transcriptional regulator
CULC0211_19400	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CULC0211_19440	COG1329	Transcriptional regulator
CULC0211_19450	COG2847	Copper chaperone PCu(A)C
CULC0211_19470	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
CULC0211_19490	COG0288	reversible hydration of carbon dioxide
CULC0211_19530	COG0542	response to heat
CULC0211_19550	COG2814	Major facilitator Superfamily
CULC0211_19560	COG1957	nucleoside hydrolase
CULC0211_19630	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
CULC0211_19660	COG1301	dicarboxylic acid transport
CULC0211_19680	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CULC0211_19690	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
CULC0211_19700	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
CULC0211_19770	COG0302	gtp cyclohydrolase
CULC0211_19780	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CULC0211_19820	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
CULC0211_19830	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CULC0211_19840	COG1301	dicarboxylic acid transport
CULC0211_19890	COG2326	polyphosphate kinase activity
CULC0211_19950	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CULC0211_19980	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CULC0211_19980	COG2111	Na H antiporter
CULC0211_20040	COG1051	belongs to the nudix hydrolase family
CULC0211_20080	COG0242	peptide deformylase activity
CULC0211_20100	COG0708	Exodeoxyribonuclease III
CULC0211_20110	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CULC0211_20130	COG1131	(ABC) transporter
CULC0211_20160	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CULC0211_20190	COG0280	phosphate acetyltransferase
CULC0211_20230	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
CULC0211_20240	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
CULC0211_20330	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CULC0211_20360	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
CULC0211_20370	COG3005	denitrification pathway
CULC0211_20400	COG4129	membrane
CULC0211_20430	COG4129	membrane
CULC0211_20470	COG0191	fructose-bisphosphate aldolase activity
CULC0211_20500	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
CULC0211_20530	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
CULC0211_20620	COG1131	(ABC) transporter
CULC0211_20700	COG1136	(ABC) transporter
CULC0211_20710	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CULC0211_20720	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CULC0211_20760	COG1012	belongs to the aldehyde dehydrogenase family
CULC0211_20790	COG0789	Transcriptional regulator
CULC0211_20820	COG0443	Heat shock 70 kDa protein
CULC0211_20880	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CULC0211_20890	COG0601	transmembrane transport
CULC0211_20930	COG2181	nitrate reductase activity
CULC0211_20930	COG0247	lactate metabolic process
CULC0211_20960	COG1120	ATPase activity
CULC0211_20970	COG4139	cobalamin transport
CULC0211_20990	COG0829	nickel cation binding
CULC0211_21000	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
CULC0211_21010	COG0830	nickel cation binding
CULC0211_21020	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
CULC0211_21030	COG0804	urea catabolic process
CULC0211_21040	COG0832	Belongs to the urease beta subunit family
CULC0211_21050	COG0831	urea catabolic process
CULC0211_21090	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
CULC0211_21090	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
CULC0211_21130	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
CULC0211_21150	COG1012	belongs to the aldehyde dehydrogenase family
CULC0211_21190	COG1129	ABC transporter
CULC0211_21230	COG1472	Belongs to the glycosyl hydrolase 3 family
CULC0211_21250	COG4981	capsule polysaccharide biosynthetic process
CULC0211_21260	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
CULC0211_21260	COG2755	lipolytic protein G-D-S-L family
CULC0211_21290	COG0438	transferase activity, transferring glycosyl groups
CULC0211_21300	COG0500	methyltransferase
CULC0211_21390	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CULC0211_21400	COG3321	synthase
CULC0211_21400	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CULC0211_21440	COG5479	isomerase activity
CULC0211_21440	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
CULC0211_21450	COG5650	phosphatidylinositol metabolic process
CULC0211_21470	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
CULC0211_21480	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
CULC0211_21490	COG0671	phosphoesterase, PA-phosphatase related
CULC0211_21500	COG1216	Glycosyl transferase, family 2
CULC0211_21520	COG0671	phosphoesterase, PA-phosphatase related
CULC0211_21530	COG0584	glycerophosphoryl diester phosphodiesterase
CULC0211_21540	COG2271	Major facilitator Superfamily
CULC0211_21560	COG1120	ATPase activity
CULC0211_21570	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CULC0211_21580	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CULC0211_21600	COG0561	phosphatase activity
CULC0211_21640	COG2188	Transcriptional regulator
CULC0211_21680	COG0077	Prephenate dehydratase
CULC0211_21710	COG1316	TRANSCRIPTIONal
CULC0211_21740	COG1115	amino acid carrier protein
CULC0211_21750	COG1115	amino acid carrier protein
CULC0211_21780	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CULC0211_21840	COG0431	NADPH-dependent FMN reductase
CULC0211_21850	COG0583	DNA-binding transcription factor activity
CULC0211_21860	COG2814	Major facilitator Superfamily
CULC0211_21900	COG5650	phosphatidylinositol metabolic process
CULC0211_21940	COG2197	response regulator
CULC0211_21980	COG3764	Sortase (surface protein transpeptidase)
CULC0211_21990	COG0706	membrane insertase activity
CULC0211_22040	COG0564	pseudouridine synthase activity
CULC0211_22060	COG1131	(ABC) transporter
CULC0211_22100	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CULC0211_22140	COG0596	Alpha beta hydrolase
CULC0211_22180	COG0477	Major facilitator Superfamily
CULC0211_22190	COG0305	Participates in initiation and elongation during chromosome replication
CULC0211_22200	COG3387	PFAM Glycoside hydrolase 15-related
CULC0211_22220	COG0629	single-stranded DNA binding
CULC0211_22260	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CULC0211_22300	COG0300	oxidoreductase activity
CULC0211_22330	COG0586	Pfam SNARE associated Golgi protein
CULC0211_22350	COG0783	Belongs to the Dps family
CULC0211_22360	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
CULC0211_22370	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
CULC0211_22370	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
CULC0211_22390	COG1511	domain protein
CULC0211_22450	COG3851	Histidine kinase
CULC0211_22460	COG2197	response regulator
CULC0211_22510	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
CULC0211_22530	COG1940	carbohydrate kinase activity
CULC0211_22540	COG2186	Transcriptional regulator
CULC0211_22550	COG0747	negative chemotaxis
CULC0211_22560	COG0601	transmembrane transport
CULC0211_22570	COG0444	Belongs to the ABC transporter superfamily
CULC0211_22580	COG4608	Belongs to the ABC transporter superfamily
CULC0211_22590	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CULC0211_22650	COG1012	belongs to the aldehyde dehydrogenase family
CULC0211_22730	COG3422	double-strand break repair
CULC0211_22760	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
CULC0211_22800	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
CULC0211_22810	COG0512	Glutamine amidotransferase of anthranilate synthase
CULC0211_22830	COG0134	indole-3-glycerol-phosphate synthase activity
CULC0211_22830	COG0135	phosphoribosylanthranilate isomerase activity
CULC0211_22840	COG0133	tryptophan synthase activity
CULC0211_22900	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
CULC0211_22910	COG1678	Uncharacterized ACR, COG1678
CULC0211_22920	COG0617	tRNA 3'-terminal CCA addition
CULC0211_22990	COG3409	Peptidoglycan-binding domain 1 protein
CULC0211_22990	COG0860	N-Acetylmuramoyl-L-alanine amidase
CULC0211_23020	COG1192	Involved in chromosome partitioning
CULC0211_23050	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
CULC0211_23070	COG0230	Belongs to the bacterial ribosomal protein bL34 family