locus-tag	class	description
CULC809_00002	COG0592	DNA-directed DNA polymerase activity
CULC809_00005	COG0187	DNA topoisomerase II activity
CULC809_00009	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
CULC809_00032	COG1518	maintenance of DNA repeat elements
CULC809_00041	COG1120	ATPase activity
CULC809_00042	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CULC809_00043	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CULC809_00044	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CULC809_00046	COG2815	serine threonine protein kinase
CULC809_00046	COG0515	serine threonine protein kinase
CULC809_00047	COG0515	serine threonine protein kinase
CULC809_00048	COG0768	penicillin binding
CULC809_00052	COG1716	ATPase activity
CULC809_00052	COG1716	ATPase activity
CULC809_00054	COG1131	(ABC) transporter
CULC809_00055	COG4585	Histidine kinase
CULC809_00056	COG2197	response regulator
CULC809_00059	COG2897	thiosulfate sulfurtransferase activity
CULC809_00063	COG1120	ATPase activity
CULC809_00064	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CULC809_00065	COG2239	Acts as a magnesium transporter
CULC809_00066	COG0366	Alpha amylase catalytic
CULC809_00070	COG2197	response regulator
CULC809_00083	COG0517	IMP dehydrogenase activity
CULC809_00083	COG1125	glycine betaine transport
CULC809_00087	COG2197	response regulator
CULC809_00091	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CULC809_00095	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
CULC809_00099	COG3409	Peptidoglycan-binding domain 1 protein
CULC809_00099	COG3757	hydrolase, family 25
CULC809_00103	COG0477	Major facilitator Superfamily
CULC809_00110	COG1468	defense response to virus
CULC809_00110	COG1518	maintenance of DNA repeat elements
CULC809_00118	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
CULC809_00123	COG1846	Transcriptional regulator
CULC809_00126	COG3180	Ammonia monooxygenase
CULC809_00128	COG0730	response to heat
CULC809_00130	COG3037	sugar-specific permease SgaT UlaA
CULC809_00131	COG1643	Atp-dependent helicase
CULC809_00132	COG0110	maltose O-acetyltransferase activity
CULC809_00133	COG3145	DNA-N1-methyladenine dioxygenase activity
CULC809_00134	COG0519	Catalyzes the synthesis of GMP from XMP
CULC809_00136	COG1280	lysine exporter protein (LysE YggA)
CULC809_00137	COG0393	Putative heavy-metal-binding
CULC809_00138	COG2501	S4 domain
CULC809_00141	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
CULC809_00142	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
CULC809_00144	COG3590	peptidase
CULC809_00150	COG1028	Short-chain dehydrogenase reductase Sdr
CULC809_00151	COG0277	FAD linked oxidase domain protein
CULC809_00156	COG1216	Glycosyl transferase, family 2
CULC809_00157	COG0803	Belongs to the bacterial solute-binding protein 9 family
CULC809_00158	COG1121	(ABC) transporter
CULC809_00159	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CULC809_00160	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CULC809_00161	COG0803	Belongs to the bacterial solute-binding protein 9 family
CULC809_00169	COG0471	metal ion transport
CULC809_00171	COG1263	PTS System
CULC809_00171	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CULC809_00172	COG2190	(PTS) system
CULC809_00172	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
CULC809_00172	COG1263	PTS System
CULC809_00176	COG4974	Belongs to the 'phage' integrase family
CULC809_00180	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CULC809_00184	COG0287	Prephenate dehydrogenase
CULC809_00185	COG0590	tRNA wobble adenosine to inosine editing
CULC809_00186	COG2409	Drug exporters of the RND superfamily
CULC809_00187	COG0343	queuine tRNA-ribosyltransferase activity
CULC809_00189	COG2610	gluconate transmembrane transporter activity
CULC809_00190	COG3265	gluconokinase activity
CULC809_00191	COG1063	alcohol dehydrogenase
CULC809_00192	COG1028	Short-chain dehydrogenase reductase Sdr
CULC809_00193	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
CULC809_00198	COG2610	gluconate transmembrane transporter activity
CULC809_00199	COG2084	Dehydrogenase
CULC809_00201	COG2186	Transcriptional regulator
CULC809_00202	COG0179	Fumarylacetoacetate (FAA) hydrolase
CULC809_00205	COG3442	glutamine amidotransferase
CULC809_00206	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
CULC809_00209	COG0778	Nitroreductase
CULC809_00211	COG2390	Transcriptional regulator
CULC809_00212	COG0813	purine-nucleoside phosphorylase activity
CULC809_00213	COG2814	Major facilitator Superfamily
CULC809_00215	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CULC809_00219	COG0697	spore germination
CULC809_00220	COG1131	(ABC) transporter
CULC809_00222	COG0527	aspartate kinase activity
CULC809_00224	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
CULC809_00239	COG2111	Na H antiporter
CULC809_00239	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CULC809_00243	COG4152	abc transporter atp-binding protein
CULC809_00245	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CULC809_00250	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
CULC809_00254	COG0494	nUDIX hydrolase
CULC809_00267	COG1205	dead DEAH box helicase
CULC809_00267	COG1111	helicase
CULC809_00269	COG1754	DNA topoisomerase type I activity
CULC809_00269	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
CULC809_00270	COG1297	OPT oligopeptide transporter protein
CULC809_00272	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
CULC809_00274	COG0318	PFAM AMP-dependent synthetase and ligase
CULC809_00278	COG1088	dTDP-glucose 4,6-dehydratase activity
CULC809_00280	COG1505	serine-type exopeptidase activity
CULC809_00283	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
CULC809_00284	COG3800	Transcriptional regulator
CULC809_00284	COG1396	sequence-specific DNA binding
CULC809_00286	COG1053	succinate dehydrogenase
CULC809_00287	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
CULC809_00289	COG2733	membrane
CULC809_00291	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
CULC809_00293	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
CULC809_00295	COG1882	Formate acetyltransferase
CULC809_00299	COG0318	PFAM AMP-dependent synthetase and ligase
CULC809_00302	COG5002	protein histidine kinase activity
CULC809_00303	COG0745	RESPONSE REGULATOR receiver
CULC809_00307	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
CULC809_00310	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
CULC809_00310	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
CULC809_00312	COG0560	Phosphoserine phosphatase
CULC809_00317	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CULC809_00317	COG1648	precorrin-2 dehydrogenase activity
CULC809_00320	COG2217	Heavy metal translocating P-type atpase
CULC809_00325	COG0406	alpha-ribazole phosphatase activity
CULC809_00327	COG0785	Cytochrome C biogenesis protein
CULC809_00330	COG1120	ATPase activity
CULC809_00332	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CULC809_00333	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CULC809_00339	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
CULC809_00341	COG3069	C4-dicarboxylate transmembrane transporter activity
CULC809_00342	COG4948	Mandelate Racemase Muconate Lactonizing
CULC809_00345	COG0438	transferase activity, transferring glycosyl groups
CULC809_00345	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
CULC809_00347	COG0039	L-malate dehydrogenase activity
CULC809_00348	COG0644	oxidoreductase
CULC809_00350	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CULC809_00356	COG1902	pentaerythritol trinitrate reductase activity
CULC809_00362	COG1121	(ABC) transporter
CULC809_00363	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CULC809_00371	COG2197	response regulator
CULC809_00375	COG1131	(ABC) transporter
CULC809_00378	COG0701	Predicted permease
CULC809_00393	COG1302	Protein conserved in bacteria
CULC809_00394	COG0051	transcription antitermination factor activity, RNA binding
CULC809_00405	COG0747	negative chemotaxis
CULC809_00412	COG0814	amino acid
CULC809_00413	COG1760	l-serine dehydratase
CULC809_00414	COG0252	asparaginase activity
CULC809_00415	COG0671	phosphoesterase, PA-phosphatase related
CULC809_00424	COG1175	transmembrane transport
CULC809_00425	COG3833	ABC-type maltose transport systems, permease component
CULC809_00429	COG3842	ATPase activity
CULC809_00431	COG0201	protein transport
CULC809_00441	COG0203	ribosomal protein L17
CULC809_00445	COG1404	Belongs to the peptidase S8 family
CULC809_00447	COG1674	ftsk spoiiie
CULC809_00458	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
CULC809_00463	COG0456	acetyltransferase
CULC809_00472	COG0516	GMP reductase activity
CULC809_00478	COG2197	response regulator
CULC809_00481	COG2011	ABC-type metal ion transport system permease component
CULC809_00484	COG1464	Belongs to the NlpA lipoprotein family
CULC809_00487	COG0803	Belongs to the bacterial solute-binding protein 9 family
CULC809_00488	COG1121	(ABC) transporter
CULC809_00489	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CULC809_00490	COG1108	ABC-type Mn2 Zn2 transport systems permease components
CULC809_00490	COG1321	iron dependent repressor
CULC809_00492	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
CULC809_00500	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CULC809_00501	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
CULC809_00503	COG2873	o-acetylhomoserine
CULC809_00504	COG2838	Isocitrate dehydrogenase
CULC809_00505	COG2814	Major facilitator Superfamily
CULC809_00506	COG4978	Transcriptional regulator
CULC809_00506	COG0789	Transcriptional regulator
CULC809_00510	COG0180	Tryptophanyl-tRNA synthetase
CULC809_00511	COG1295	ribonuclease BN
CULC809_00512	COG1686	Belongs to the peptidase S11 family
CULC809_00519	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
CULC809_00520	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
CULC809_00520	COG1473	amidohydrolase
CULC809_00522	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
CULC809_00523	COG2814	Major facilitator Superfamily
CULC809_00525	COG4770	biotin carboxylase activity
CULC809_00526	COG2897	thiosulfate sulfurtransferase activity
CULC809_00527	COG0189	ligase activity
CULC809_00528	COG2755	lipolytic protein G-D-S-L family
CULC809_00528	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
CULC809_00531	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
CULC809_00532	COG1609	Transcriptional regulator
CULC809_00534	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CULC809_00535	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CULC809_00536	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
CULC809_00536	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
CULC809_00541	COG4555	ABC transporter
CULC809_00547	COG1120	ATPase activity
CULC809_00553	COG1316	TRANSCRIPTIONal
CULC809_00555	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
CULC809_00561	COG1482	cell wall glycoprotein biosynthetic process
CULC809_00566	COG0745	RESPONSE REGULATOR receiver
CULC809_00567	COG5002	protein histidine kinase activity
CULC809_00569	COG1040	competence protein
CULC809_00570	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
CULC809_00577	COG1162	GTPase activity
CULC809_00579	COG2135	peptidase activity
CULC809_00580	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
CULC809_00587	COG0513	Belongs to the DEAD box helicase family
CULC809_00592	COG0210	DNA helicase
CULC809_00594	COG2816	NAD+ diphosphatase activity
CULC809_00599	COG3480	Lon protease (S16) C-terminal proteolytic domain
CULC809_00616	COG0483	inositol monophosphate 1-phosphatase activity
CULC809_00617	COG0483	inositol monophosphate 1-phosphatase activity
CULC809_00620	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
CULC809_00621	COG2884	Cell division ATP-binding protein ftsE
CULC809_00622	COG2177	Part of the ABC transporter FtsEX involved in
CULC809_00624	COG0288	reversible hydration of carbon dioxide
CULC809_00638	COG1652	LysM domain
CULC809_00640	COG1278	Cold shock
CULC809_00644	COG2252	PERMEase
CULC809_00645	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CULC809_00649	COG0372	Belongs to the citrate synthase family
CULC809_00650	COG0545	Peptidyl-prolyl cis-trans isomerase
CULC809_00653	COG0656	L-ascorbic acid biosynthetic process
CULC809_00654	COG1024	Enoyl-CoA hydratase
CULC809_00656	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CULC809_00658	COG3757	hydrolase, family 25
CULC809_00661	COG0534	Mate efflux family protein
CULC809_00662	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
CULC809_00663	COG0019	diaminopimelate decarboxylase activity
CULC809_00666	COG4166	transmembrane transport
CULC809_00668	COG4171	peptide transport system, permease
CULC809_00677	COG1218	3'(2'),5'-bisphosphate nucleotidase
CULC809_00678	COG1201	RNA secondary structure unwinding
CULC809_00680	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
CULC809_00684	COG1605	Chorismate mutase
CULC809_00686	COG0739	heme binding
CULC809_00690	COG1126	abc transporter atp-binding protein
CULC809_00691	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CULC809_00692	COG0765	amino acid transport
CULC809_00693	COG0765	amino acid transport
CULC809_00701	COG0254	rRNA binding
CULC809_00703	COG0745	RESPONSE REGULATOR receiver
CULC809_00704	COG2205	protein histidine kinase activity
CULC809_00705	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
CULC809_00706	COG0315	cyclic pyranopterin monophosphate synthase activity
CULC809_00706	COG0521	Mo-molybdopterin cofactor biosynthetic process
CULC809_00708	COG1970	mechanosensitive ion channel activity
CULC809_00711	COG1210	Utp--glucose-1-phosphate uridylyltransferase
CULC809_00715	COG2259	Doxx family
CULC809_00717	COG1928	C-terminal four TMM region of protein-O-mannosyltransferase
CULC809_00718	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CULC809_00719	COG3949	Membrane
CULC809_00722	COG0084	hydrolase, TatD family'
CULC809_00723	COG3583	domain protein
CULC809_00726	COG0488	(ABC) transporter
CULC809_00731	COG2326	polyphosphate kinase activity
CULC809_00739	COG0596	Alpha beta hydrolase
CULC809_00740	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
CULC809_00742	COG0193	aminoacyl-tRNA hydrolase activity
CULC809_00743	COG2070	2-Nitropropane dioxygenase
CULC809_00746	COG1523	belongs to the glycosyl hydrolase 13 family
CULC809_00747	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
CULC809_00748	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
CULC809_00749	COG2132	Multicopper oxidase
CULC809_00751	COG1309	transcriptional regulator
CULC809_00753	COG0531	amino acid
CULC809_00754	COG3956	TIGRFAM MazG family protein
CULC809_00767	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
CULC809_00781	COG0114	fumarate hydratase activity
CULC809_00782	COG1494	fructose-1,6-bisphosphatase
CULC809_00789	COG0012	GTP binding
CULC809_00791	COG2824	Alkylphosphonate utilization operon protein PhnA
CULC809_00792	COG1132	(ABC) transporter
CULC809_00793	COG1132	(ABC) transporter
CULC809_00794	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
CULC809_00795	COG2354	Protein conserved in bacteria
CULC809_00797	COG4721	ABC-type cobalt transport system, permease component
CULC809_00798	COG4172	Belongs to the ABC transporter superfamily
CULC809_00800	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
CULC809_00801	COG1051	belongs to the nudix hydrolase family
CULC809_00802	COG4166	transmembrane transport
CULC809_00803	COG0601	transmembrane transport
CULC809_00807	COG1136	(ABC) transporter
CULC809_00809	COG5640	endopeptidase activity
CULC809_00821	COG1113	amino acid transport
CULC809_00823	COG1113	amino acid transport
CULC809_00825	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CULC809_00827	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
CULC809_00828	COG0463	Glycosyl transferase, family 2
CULC809_00833	COG3527	Alpha-acetolactate decarboxylase
CULC809_00834	COG0297	glycogen (starch) synthase activity
CULC809_00836	COG4122	O-methyltransferase activity
CULC809_00837	COG1595	DNA-templated transcription, initiation
CULC809_00842	COG2239	Acts as a magnesium transporter
CULC809_00844	COG0567	Dehydrogenase, E1 component
CULC809_00844	COG0508	dehydrogenase complex catalyzes the overall conversion of
CULC809_00845	COG1132	(ABC) transporter
CULC809_00847	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
CULC809_00848	COG2272	Belongs to the type-B carboxylesterase lipase family
CULC809_00852	COG2017	converts alpha-aldose to the beta-anomer
CULC809_00856	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
CULC809_00862	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
CULC809_00863	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
CULC809_00868	COG1846	Transcriptional regulator
CULC809_00871	COG1349	DNA-binding transcription factor activity
CULC809_00873	COG1556	Lactate utilization protein
CULC809_00874	COG1139	Iron-sulfur cluster binding protein
CULC809_00875	COG0247	lactate metabolic process
CULC809_00876	COG1620	l-lactate permease
CULC809_00878	COG0019	diaminopimelate decarboxylase activity
CULC809_00879	COG0460	homoserine dehydrogenase
CULC809_00889	COG0356	it plays a direct role in the translocation of protons across the membrane
CULC809_00890	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
CULC809_00891	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
CULC809_00905	COG1119	ATPase activity
CULC809_00909	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
CULC809_00922	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CULC809_00923	COG1120	ATPase activity
CULC809_00926	COG0205	6-phosphofructokinase activity
CULC809_00928	COG0667	Aldo Keto reductase
CULC809_00930	COG0583	DNA-binding transcription factor activity
CULC809_00931	COG0435	Glutathione S-transferase
CULC809_00936	COG0668	transmembrane transport
CULC809_00937	COG0028	Belongs to the TPP enzyme family
CULC809_00945	COG0473	3-isopropylmalate dehydrogenase activity
CULC809_00949	COG0179	Fumarylacetoacetate (FAA) hydrolase
CULC809_00957	COG0601	transmembrane transport
CULC809_00958	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CULC809_00959	COG0444	Belongs to the ABC transporter superfamily
CULC809_00960	COG4608	Belongs to the ABC transporter superfamily
CULC809_00961	COG0747	negative chemotaxis
CULC809_00971	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
CULC809_00972	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
CULC809_00973	COG1461	Dihydroxyacetone kinase
CULC809_00975	COG0511	ligase activity, forming carbon-carbon bonds
CULC809_00976	COG0742	ribosomal rna small subunit methyltransferase
CULC809_00981	COG0765	amino acid transport
CULC809_00987	COG0539	negative regulation of cytoplasmic translation
CULC809_00993	COG3973	AAA domain
CULC809_00995	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CULC809_00998	COG0291	Belongs to the bacterial ribosomal protein bL35 family
CULC809_01001	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CULC809_01007	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
CULC809_01008	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
CULC809_01011	COG0165	Argininosuccinate lyase
CULC809_01012	COG2835	tetraacyldisaccharide 4'-kinase activity
CULC809_01018	COG0647	UMP catabolic process
CULC809_01025	COG4974	Belongs to the 'phage' integrase family
CULC809_01029	COG3104	oligopeptide transport
CULC809_01030	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
CULC809_01032	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
CULC809_01035	COG1160	GTP binding
CULC809_01036	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
CULC809_01038	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
CULC809_01039	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
CULC809_01040	COG4594	ABC-type Fe3 -citrate transport system, periplasmic component
CULC809_01042	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CULC809_01043	COG1120	ATPase activity
CULC809_01044	COG4264	IucA IucC family
CULC809_01047	COG3012	SEC-C Motif Domain Protein
CULC809_01057	COG1253	flavin adenine dinucleotide binding
CULC809_01058	COG0513	Belongs to the DEAD box helicase family
CULC809_01059	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
CULC809_01061	COG0598	Magnesium transport protein CorA
CULC809_01063	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
CULC809_01068	COG0477	Major facilitator Superfamily
CULC809_01069	COG0277	FAD linked oxidase domain protein
CULC809_01075	COG0463	Glycosyl transferase, family 2
CULC809_01086	COG0300	oxidoreductase activity
CULC809_01089	COG0805	protein transport
CULC809_01091	COG2378	regulation of single-species biofilm formation
CULC809_01095	COG4122	O-methyltransferase activity
CULC809_01098	COG1362	aminopeptidase activity
CULC809_01102	COG1027	Aspartate ammonia-lyase
CULC809_01103	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
CULC809_01106	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
CULC809_01107	COG0646	methionine synthase
CULC809_01107	COG1410	methionine synthase
CULC809_01111	COG0667	Aldo Keto reductase
CULC809_01113	COG0167	dihydroorotate dehydrogenase activity
CULC809_01116	COG1881	PFAM PEBP family protein
CULC809_01118	COG1461	Dihydroxyacetone kinase
CULC809_01119	COG2376	Dihydroxyacetone kinase
CULC809_01133	COG0791	NLP P60 protein
CULC809_01133	COG3883	PFAM NLP P60 protein
CULC809_01139	COG2848	UPF0210 protein
CULC809_01162	COG0740	serine-type endopeptidase activity
CULC809_01174	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CULC809_01174	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
CULC809_01182	COG3561	AntA/AntB antirepressor
CULC809_01186	COG4974	Belongs to the 'phage' integrase family
CULC809_01188	COG2151	metal-sulfur cluster biosynthetic enzyme
CULC809_01189	COG0822	iron-sulfur transferase activity
CULC809_01191	COG0396	ATPase activity
CULC809_01200	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
CULC809_01201	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
CULC809_01205	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
CULC809_01209	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
CULC809_01211	COG0391	Required for morphogenesis under gluconeogenic growth conditions
CULC809_01213	COG0322	excinuclease ABC activity
CULC809_01222	COG0242	peptide deformylase activity
CULC809_01230	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
CULC809_01232	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
CULC809_01234	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
CULC809_01235	COG1090	epimerase
CULC809_01241	COG0006	proline dipeptidase activity
CULC809_01242	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
CULC809_01243	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
CULC809_01245	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
CULC809_01249	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
CULC809_01259	COG1760	l-serine dehydratase
CULC809_01261	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
CULC809_01262	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
CULC809_01265	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
CULC809_01267	COG0747	negative chemotaxis
CULC809_01268	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CULC809_01269	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
CULC809_01273	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
CULC809_01275	COG1946	Acyl-CoA thioesterase
CULC809_01278	COG0156	8-amino-7-oxononanoate synthase activity
CULC809_01280	COG0438	transferase activity, transferring glycosyl groups
CULC809_01281	COG1560	Kdo2-lipid A biosynthetic process
CULC809_01285	COG2837	iron assimilation
CULC809_01291	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
CULC809_01317	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
CULC809_01318	COG0450	alkyl hydroperoxide reductase
CULC809_01321	COG1643	Atp-dependent helicase
CULC809_01325	COG1349	DNA-binding transcription factor activity
CULC809_01326	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CULC809_01327	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
CULC809_01327	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
CULC809_01328	COG1349	DNA-binding transcription factor activity
CULC809_01330	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
CULC809_01330	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CULC809_01330	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CULC809_01331	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
CULC809_01335	COG2233	PERMEase
CULC809_01336	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
CULC809_01339	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
CULC809_01342	COG1196	nuclear chromosome segregation
CULC809_01346	COG2137	regulation of response to DNA damage stimulus
CULC809_01347	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
CULC809_01349	COG1268	BioY protein
CULC809_01350	COG1122	ATPase activity
CULC809_01353	COG1396	sequence-specific DNA binding
CULC809_01354	COG1546	Belongs to the CinA family
CULC809_01354	COG1058	Belongs to the CinA family
CULC809_01357	COG0861	Integral membrane protein TerC family
CULC809_01358	COG1674	ftsk spoiiie
CULC809_01360	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
CULC809_01368	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
CULC809_01371	COG0534	Mate efflux family protein
CULC809_01380	COG3022	response to hydroperoxide
CULC809_01381	COG1648	precorrin-2 dehydrogenase activity
CULC809_01381	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
CULC809_01382	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
CULC809_01383	COG0523	cobalamin synthesis protein
CULC809_01384	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
CULC809_01384	COG2169	Transcriptional regulator
CULC809_01395	COG0768	penicillin binding
CULC809_01397	COG0750	zinc metalloprotease
CULC809_01408	COG4974	Belongs to the 'phage' integrase family
CULC809_01411	COG0606	chelatase, subunit chli
CULC809_01412	COG0792	nuclease activity
CULC809_01414	COG0352	thiamine-phosphate diphosphorylase activity
CULC809_01417	COG2022	thiamine diphosphate biosynthetic process
CULC809_01418	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
CULC809_01419	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
CULC809_01419	COG0352	thiamine-phosphate diphosphorylase activity
CULC809_01419	COG0351	phosphomethylpyrimidine kinase
CULC809_01422	COG0681	Belongs to the peptidase S26 family
CULC809_01425	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CULC809_01425	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
CULC809_01425	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
CULC809_01427	COG0336	Belongs to the RNA methyltransferase TrmD family
CULC809_01428	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
CULC809_01432	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
CULC809_01437	COG1254	Belongs to the acylphosphatase family
CULC809_01438	COG1115	amino acid carrier protein
CULC809_01444	COG0686	Belongs to the AlaDH PNT family
CULC809_01445	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
CULC809_01446	COG1929	Belongs to the glycerate kinase type-1 family
CULC809_01449	COG1473	amidohydrolase
CULC809_01450	COG0058	SHG alpha-glucan phosphorylase activity
CULC809_01452	COG0469	pyruvate kinase activity
CULC809_01454	COG0134	indole-3-glycerol-phosphate synthase activity
CULC809_01458	COG0483	inositol monophosphate 1-phosphatase activity
CULC809_01471	COG2176	DNA-directed DNA polymerase activity
CULC809_01476	COG1739	Uncharacterized protein family UPF0029
CULC809_01477	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
CULC809_01482	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
CULC809_01485	COG0252	asparaginase activity
CULC809_01489	COG3599	regulation of cell shape
CULC809_01491	COG1799	cell septum assembly
CULC809_01493	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
CULC809_01494	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
CULC809_01495	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
CULC809_01501	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
CULC809_01502	COG0768	penicillin binding
CULC809_01514	COG2815	serine threonine protein kinase
CULC809_01514	COG0515	serine threonine protein kinase
CULC809_01515	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
CULC809_01519	COG1940	carbohydrate kinase activity
CULC809_01520	COG0438	transferase activity, transferring glycosyl groups
CULC809_01522	COG0791	NLP P60 protein
CULC809_01533	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
CULC809_01535	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
CULC809_01538	COG0508	dehydrogenase complex catalyzes the overall conversion of
CULC809_01539	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CULC809_01539	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
CULC809_01540	COG0404	The glycine cleavage system catalyzes the degradation of glycine
CULC809_01541	COG0509	glycine decarboxylation via glycine cleavage system
CULC809_01545	COG1120	ATPase activity
CULC809_01546	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CULC809_01547	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CULC809_01552	COG0174	glutamine synthetase
CULC809_01554	COG3547	Transposase (IS116 IS110 IS902 family)
CULC809_01557	COG3237	CsbD-like
CULC809_01558	COG2056	Na+-H+ antiporter family
CULC809_01561	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
CULC809_01567	COG0174	glutamine synthetase
CULC809_01572	COG0557	exoribonuclease II activity
CULC809_01573	COG0406	alpha-ribazole phosphatase activity
CULC809_01573	COG0328	RNA-DNA hybrid ribonuclease activity
CULC809_01580	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
CULC809_01582	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
CULC809_01583	COG0596	Alpha beta hydrolase
CULC809_01588	COG2860	membrane
CULC809_01600	COG0423	glycine-tRNA ligase activity
CULC809_01605	COG1381	Involved in DNA repair and RecF pathway recombination
CULC809_01616	COG1022	Amp-dependent synthetase and ligase
CULC809_01626	COG1132	(ABC) transporter
CULC809_01627	COG1114	Component of the transport system for branched-chain amino acids
CULC809_01628	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
CULC809_01630	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CULC809_01633	COG0747	negative chemotaxis
CULC809_01634	COG0601	transmembrane transport
CULC809_01635	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CULC809_01636	COG4172	Belongs to the ABC transporter superfamily
CULC809_01638	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
CULC809_01639	COG2391	methyltransferase activity
CULC809_01641	COG0577	efflux transmembrane transporter activity
CULC809_01641	COG1136	(ABC) transporter
CULC809_01645	COG4172	Belongs to the ABC transporter superfamily
CULC809_01646	COG1116	anion transmembrane transporter activity
CULC809_01651	COG1280	lysine exporter protein (LysE YggA)
CULC809_01656	COG1307	EDD domain protein, DegV family
CULC809_01657	COG0406	alpha-ribazole phosphatase activity
CULC809_01659	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
CULC809_01662	COG2832	Protein of unknown function (DUF454)
CULC809_01663	COG2985	domain, Protein
CULC809_01663	COG0569	domain protein
CULC809_01668	COG1530	ribonuclease E activity
CULC809_01671	COG2423	ornithine cyclodeaminase activity
CULC809_01673	COG0285	dihydrofolate synthase activity
CULC809_01681	COG0544	peptidyl-prolyl cis-trans isomerase activity
CULC809_01686	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
CULC809_01688	COG0668	transmembrane transport
CULC809_01703	COG1131	(ABC) transporter
CULC809_01704	COG3336	cytochrome c oxidase
CULC809_01705	COG1966	Carbon starvation protein
CULC809_01708	COG0604	alcohol dehydrogenase
CULC809_01709	COG4221	oxidoreductase activity
CULC809_01712	COG1376	ErfK ybiS ycfS ynhG family protein
CULC809_01713	COG2130	NADP-dependent
CULC809_01714	COG1335	isochorismatase
CULC809_01723	COG2197	response regulator
CULC809_01729	COG1234	tRNA 3'-trailer cleavage
CULC809_01734	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
CULC809_01744	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CULC809_01746	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CULC809_01750	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
CULC809_01756	COG0640	Transcriptional regulator
CULC809_01757	COG2217	Heavy metal translocating P-type atpase
CULC809_01760	COG0033	Phosphoglucomutase
CULC809_01763	COG0577	efflux transmembrane transporter activity
CULC809_01763	COG1136	(ABC) transporter
CULC809_01764	COG0577	efflux transmembrane transporter activity
CULC809_01764	COG1136	(ABC) transporter
CULC809_01770	COG2197	response regulator
CULC809_01773	COG1045	serine acetyltransferase
CULC809_01776	COG1271	oxidase subunit
CULC809_01777	COG1294	oxidase, subunit
CULC809_01778	COG4988	ABC transporter
CULC809_01779	COG4988	ABC transporter
CULC809_01784	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
CULC809_01790	COG1597	lipid kinase activity
CULC809_01793	COG0354	folic acid binding
CULC809_01798	COG1780	Probably involved in ribonucleotide reductase function
CULC809_01799	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
CULC809_01801	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CULC809_01802	COG0047	phosphoribosylformylglycinamidine synthase activity
CULC809_01803	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
CULC809_01804	COG0386	Belongs to the glutathione peroxidase family
CULC809_01807	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
CULC809_01808	COG0569	domain protein
CULC809_01809	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
CULC809_01810	COG0151	Belongs to the GarS family
CULC809_01811	COG0537	adenosine 5'-monophosphoramidase activity
CULC809_01813	COG2205	protein histidine kinase activity
CULC809_01814	COG0745	RESPONSE REGULATOR receiver
CULC809_01815	COG0477	Major facilitator Superfamily
CULC809_01820	COG0028	Belongs to the TPP enzyme family
CULC809_01828	COG1609	Transcriptional regulator
CULC809_01830	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
CULC809_01834	COG1329	Transcriptional regulator
CULC809_01835	COG2847	Copper chaperone PCu(A)C
CULC809_01837	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
CULC809_01839	COG0288	reversible hydration of carbon dioxide
CULC809_01842	COG0542	response to heat
CULC809_01844	COG2814	Major facilitator Superfamily
CULC809_01845	COG1957	nucleoside hydrolase
CULC809_01848	COG5640	endopeptidase activity
CULC809_01849	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
CULC809_01852	COG1301	dicarboxylic acid transport
CULC809_01854	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
CULC809_01855	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
CULC809_01856	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
CULC809_01863	COG0302	gtp cyclohydrolase
CULC809_01864	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
CULC809_01869	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
CULC809_01870	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
CULC809_01871	COG1301	dicarboxylic acid transport
CULC809_01879	COG2326	polyphosphate kinase activity
CULC809_01885	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
CULC809_01889	COG2111	Na H antiporter
CULC809_01889	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
CULC809_01895	COG1051	belongs to the nudix hydrolase family
CULC809_01899	COG0242	peptide deformylase activity
CULC809_01902	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
CULC809_01904	COG1131	(ABC) transporter
CULC809_01907	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
CULC809_01910	COG0280	phosphate acetyltransferase
CULC809_01914	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
CULC809_01915	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
CULC809_01924	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
CULC809_01927	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
CULC809_01928	COG3005	denitrification pathway
CULC809_01932	COG4129	membrane
CULC809_01934	COG4129	membrane
CULC809_01941	COG0191	fructose-bisphosphate aldolase activity
CULC809_01944	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
CULC809_01947	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
CULC809_01966	COG0577	efflux transmembrane transporter activity
CULC809_01966	COG1136	(ABC) transporter
CULC809_01967	COG1136	(ABC) transporter
CULC809_01968	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
CULC809_01969	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
CULC809_01972	COG1012	belongs to the aldehyde dehydrogenase family
CULC809_01975	COG0789	Transcriptional regulator
CULC809_01978	COG0443	Heat shock 70 kDa protein
CULC809_01984	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
CULC809_01985	COG0601	transmembrane transport
CULC809_01989	COG2181	nitrate reductase activity
CULC809_01989	COG0247	lactate metabolic process
CULC809_01992	COG1120	ATPase activity
CULC809_01993	COG4139	cobalamin transport
CULC809_01995	COG0829	nickel cation binding
CULC809_01996	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
CULC809_01997	COG0830	nickel cation binding
CULC809_01998	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
CULC809_01999	COG0804	urea catabolic process
CULC809_02000	COG0832	Belongs to the urease beta subunit family
CULC809_02001	COG0831	urea catabolic process
CULC809_02005	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
CULC809_02005	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
CULC809_02008	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
CULC809_02010	COG1012	belongs to the aldehyde dehydrogenase family
CULC809_02014	COG1129	ABC transporter
CULC809_02018	COG1472	Belongs to the glycosyl hydrolase 3 family
CULC809_02019	COG4981	capsule polysaccharide biosynthetic process
CULC809_02020	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
CULC809_02020	COG2755	lipolytic protein G-D-S-L family
CULC809_02023	COG0438	transferase activity, transferring glycosyl groups
CULC809_02024	COG0500	methyltransferase
CULC809_02033	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
CULC809_02034	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
CULC809_02034	COG3321	synthase
CULC809_02038	COG5479	isomerase activity
CULC809_02038	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
CULC809_02039	COG5650	phosphatidylinositol metabolic process
CULC809_02041	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
CULC809_02042	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
CULC809_02043	COG0671	phosphoesterase, PA-phosphatase related
CULC809_02044	COG1216	Glycosyl transferase, family 2
CULC809_02046	COG0671	phosphoesterase, PA-phosphatase related
CULC809_02047	COG0584	glycerophosphoryl diester phosphodiesterase
CULC809_02048	COG2271	Major facilitator Superfamily
CULC809_02050	COG1120	ATPase activity
CULC809_02051	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
CULC809_02052	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
CULC809_02054	COG0561	phosphatase activity
CULC809_02057	COG2188	Transcriptional regulator
CULC809_02061	COG0077	Prephenate dehydratase
CULC809_02064	COG1316	TRANSCRIPTIONal
CULC809_02067	COG1115	amino acid carrier protein
CULC809_02070	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
CULC809_02076	COG0431	NADPH-dependent FMN reductase
CULC809_02077	COG0583	DNA-binding transcription factor activity
CULC809_02078	COG2814	Major facilitator Superfamily
CULC809_02081	COG5650	phosphatidylinositol metabolic process
CULC809_02085	COG2197	response regulator
CULC809_02090	COG0706	membrane insertase activity
CULC809_02095	COG0564	pseudouridine synthase activity
CULC809_02100	COG1131	(ABC) transporter
CULC809_02104	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
CULC809_02108	COG0477	Major facilitator Superfamily
CULC809_02109	COG0305	Participates in initiation and elongation during chromosome replication
CULC809_02110	COG3387	PFAM Glycoside hydrolase 15-related
CULC809_02113	COG0629	single-stranded DNA binding
CULC809_02117	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
CULC809_02121	COG4221	oxidoreductase activity
CULC809_02124	COG0586	Pfam SNARE associated Golgi protein
CULC809_02126	COG0783	Belongs to the Dps family
CULC809_02127	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
CULC809_02128	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
CULC809_02128	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
CULC809_02130	COG1511	domain protein
CULC809_02135	COG3851	Histidine kinase
CULC809_02136	COG2197	response regulator
CULC809_02141	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
CULC809_02143	COG1940	carbohydrate kinase activity
CULC809_02144	COG2186	Transcriptional regulator
CULC809_02145	COG0747	negative chemotaxis
CULC809_02146	COG0601	transmembrane transport
CULC809_02147	COG0444	Belongs to the ABC transporter superfamily
CULC809_02148	COG4608	Belongs to the ABC transporter superfamily
CULC809_02149	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
CULC809_02155	COG1012	belongs to the aldehyde dehydrogenase family
CULC809_02163	COG3422	double-strand break repair
CULC809_02170	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
CULC809_02171	COG0512	Glutamine amidotransferase of anthranilate synthase
CULC809_02173	COG0134	indole-3-glycerol-phosphate synthase activity
CULC809_02173	COG0135	phosphoribosylanthranilate isomerase activity
CULC809_02175	COG0133	tryptophan synthase activity
CULC809_02181	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
CULC809_02182	COG1678	Uncharacterized ACR, COG1678
CULC809_02183	COG0617	tRNA 3'-terminal CCA addition
CULC809_02190	COG3409	Peptidoglycan-binding domain 1 protein
CULC809_02190	COG0860	N-Acetylmuramoyl-L-alanine amidase
CULC809_02193	COG1192	Involved in chromosome partitioning
CULC809_02196	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
CULC809_02198	COG0230	Belongs to the bacterial ribosomal protein bL34 family