locus-tag	class	description
Reut_A0001	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
Reut_A0002	COG0592	DNA-directed DNA polymerase activity
Reut_A0010	COG0667	Aldo Keto reductase
Reut_A0011	COG0583	DNA-binding transcription factor activity
Reut_A0020	COG3246	L-lysine catabolic process to acetate
Reut_A0021	COG2175	clavaminate synthase activity
Reut_A0022	COG1434	Gram-negative-bacterium-type cell wall biogenesis
Reut_A0031	COG2351	hydroxyisourate hydrolase activity
Reut_A0033	COG2271	Major facilitator Superfamily
Reut_A0039	COG0513	Belongs to the DEAD box helicase family
Reut_A0040	COG0517	IMP dehydrogenase activity
Reut_A0043	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
Reut_A0043	COG0426	domain, Protein
Reut_A0048	COG2271	Major facilitator Superfamily
Reut_A0049	COG1802	Transcriptional regulator
Reut_A0051	COG1473	amidohydrolase
Reut_A0052	COG2207	Transcriptional regulator
Reut_A0053	COG2223	nitrite transmembrane transporter activity
Reut_A0059	COG0745	RESPONSE REGULATOR receiver
Reut_A0060	COG0745	RESPONSE REGULATOR receiver
Reut_A0063	COG2894	cell division
Reut_A0064	COG0850	regulation of cytokinetic process
Reut_A0065	COG0598	Magnesium transport protein CorA
Reut_A0068	COG2308	Evidence 4 Homologs of previously reported genes of
Reut_A0068	COG2307	Protein conserved in bacteria
Reut_A0075	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
Reut_A0076	COG1077	Cell shape determining protein MreB Mrl
Reut_A0077	COG1792	Involved in formation and maintenance of cell shape
Reut_A0079	COG0768	penicillin binding
Reut_A0080	COG0772	Belongs to the SEDS family
Reut_A0082	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
Reut_A0083	COG0583	DNA-binding transcription factor activity
Reut_A0087	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
Reut_A0088	COG1984	allophanate hydrolase subunit 2
Reut_A0094	COG2831	hemolysin activation secretion protein
Reut_A0100	COG1127	ABC transporter
Reut_A0101	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
Reut_A0102	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
Reut_A0102	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
Reut_A0105	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
Reut_A0115	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
Reut_A0119	COG1410	methionine synthase
Reut_A0119	COG0646	methionine synthase
Reut_A0121	COG2197	response regulator
Reut_A0122	COG2201	protein-glutamate methylesterase activity
Reut_A0129	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
Reut_A0130	COG4221	oxidoreductase activity
Reut_A0135	COG1960	acyl-CoA dehydrogenase activity
Reut_A0137	COG0288	reversible hydration of carbon dioxide
Reut_A0138	COG0183	Belongs to the thiolase family
Reut_A0140	COG1960	acyl-CoA dehydrogenase activity
Reut_A0142	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
Reut_A0145	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
Reut_A0149	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
Reut_A0152	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
Reut_A0157	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Reut_A0158	COG3328	transposase activity
Reut_A0159	COG4206	TonB-dependent receptor
Reut_A0162	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
Reut_A0163	COG0523	cobalamin synthesis protein
Reut_A0165	COG0596	Alpha beta hydrolase
Reut_A0175	COG0583	DNA-binding transcription factor activity
Reut_A0179	COG1595	DNA-templated transcription, initiation
Reut_A0182	COG1309	transcriptional regulator
Reut_A0183	COG4452	Inner membrane protein CreD
Reut_A0184	COG2205	protein histidine kinase activity
Reut_A0185	COG0745	RESPONSE REGULATOR receiver
Reut_A0191	COG2223	nitrite transmembrane transporter activity
Reut_A0193	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
Reut_A0194	COG0708	Exodeoxyribonuclease III
Reut_A0195	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
Reut_A0197	COG2326	polyphosphate kinase activity
Reut_A0204	COG1960	acyl-CoA dehydrogenase activity
Reut_A0212	COG0351	phosphomethylpyrimidine kinase
Reut_A0214	COG1950	PFAM Membrane protein of
Reut_A0215	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
Reut_A0216	COG3070	regulator of competence-specific genes
Reut_A0218	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
Reut_A0230	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
Reut_A0233	COG2391	methyltransferase activity
Reut_A0234	COG0640	Transcriptional regulator
Reut_A0235	COG1733	regulation of RNA biosynthetic process
Reut_A0237	COG1733	regulation of RNA biosynthetic process
Reut_A0238	COG1566	PFAM secretion protein HlyD family protein
Reut_A0242	COG3181	Tripartite tricarboxylate transporter family receptor
Reut_A0247	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
Reut_A0250	COG0531	amino acid
Reut_A0253	COG1703	isobutyryl-CoA mutase activity
Reut_A0253	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
Reut_A0253	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
Reut_A0254	COG0537	adenosine 5'-monophosphoramidase activity
Reut_A0255	COG1250	3-hydroxyacyl-CoA dehydrogenase
Reut_A0260	COG1022	Amp-dependent synthetase and ligase
Reut_A0262	COG0559	Belongs to the binding-protein-dependent transport system permease family
Reut_A0267	COG2832	Protein of unknown function (DUF454)
Reut_A0269	COG1414	Transcriptional regulator
Reut_A0272	COG3971	2-oxopent-4-enoate hydratase activity
Reut_A0273	COG2814	Major facilitator Superfamily
Reut_A0275	COG2204	response regulator
Reut_A0278	COG3411	Ferredoxin
Reut_A0280	COG1686	Belongs to the peptidase S11 family
Reut_A0281	COG2921	Belongs to the UPF0250 family
Reut_A0282	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
Reut_A0287	COG1280	lysine exporter protein (LysE YggA)
Reut_A0289	COG2960	long-chain fatty acid transporting porin activity
Reut_A0292	COG0004	ammonium transporteR
Reut_A0294	COG0189	ligase activity
Reut_A0296	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
Reut_A0297	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
Reut_A0300	COG0709	Synthesizes selenophosphate from selenide and ATP
Reut_A0302	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
Reut_A0303	COG0793	Belongs to the peptidase S41A family
Reut_A0305	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
Reut_A0306	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
Reut_A0309	COG3181	Tripartite tricarboxylate transporter family receptor
Reut_A0311	COG1040	competence protein
Reut_A0312	COG2226	methyltransferase
Reut_A0322	COG1612	heme a metabolic process
Reut_A0324	COG1999	signal sequence binding
Reut_A0326	COG1741	Belongs to the pirin family
Reut_A0327	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
Reut_A0328	COG1116	anion transmembrane transporter activity
Reut_A0329	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
Reut_A0330	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
Reut_A0331	COG3707	response regulator
Reut_A0333	COG0625	glutathione transferase activity
Reut_A0335	COG0612	Peptidase, M16
Reut_A0336	COG0612	Peptidase, M16
Reut_A0337	COG0742	ribosomal rna small subunit methyltransferase
Reut_A0339	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
Reut_A0342	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
Reut_A0348	COG1194	a g-specific adenine glycosylase
Reut_A0354	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
Reut_A0355	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
Reut_A0356	COG1137	ATPase activity
Reut_A0362	COG0693	protein deglycase activity
Reut_A0364	COG1280	lysine exporter protein (LysE YggA)
Reut_A0368	COG2814	Major facilitator Superfamily
Reut_A0369	COG0629	single-stranded DNA binding
Reut_A0374	COG3162	membrane
Reut_A0375	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
Reut_A0379	COG0025	NhaP-type Na H and K H
Reut_A0390	COG0745	RESPONSE REGULATOR receiver
Reut_A0391	COG2205	protein histidine kinase activity
Reut_A0396	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Reut_A0398	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
Reut_A0407	COG0842	Transport permease protein
Reut_A0408	COG1131	(ABC) transporter
Reut_A0410	COG1309	transcriptional regulator
Reut_A0413	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
Reut_A0416	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
Reut_A0419	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
Reut_A0426	COG1238	metal cluster binding
Reut_A0429	COG4178	(ABC) transporter
Reut_A0434	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
Reut_A0443	COG1763	Mo-molybdopterin cofactor biosynthetic process
Reut_A0444	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
Reut_A0446	COG1960	acyl-CoA dehydrogenase activity
Reut_A0447	COG1024	Enoyl-CoA hydratase
Reut_A0447	COG1250	3-hydroxyacyl-CoA dehydrogenase
Reut_A0448	COG0183	Belongs to the thiolase family
Reut_A0450	COG1024	Enoyl-CoA hydratase
Reut_A0451	COG1607	acyl-coa hydrolase
Reut_A0452	COG5265	(ABC) transporter
Reut_A0453	COG1522	sequence-specific DNA binding
Reut_A0456	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
Reut_A0458	COG0765	amino acid transport
Reut_A0459	COG0765	amino acid transport
Reut_A0460	COG1126	abc transporter atp-binding protein
Reut_A0461	COG0121	glutamine amidotransferase
Reut_A0462	COG0473	3-isopropylmalate dehydrogenase activity
Reut_A0466	COG1765	OsmC-like protein
Reut_A0471	COG0316	Belongs to the HesB IscA family
Reut_A0475	COG0739	heme binding
Reut_A0478	COG1881	PFAM PEBP family protein
Reut_A0479	COG0406	alpha-ribazole phosphatase activity
Reut_A0485	COG0584	glycerophosphoryl diester phosphodiesterase
Reut_A0488	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
Reut_A0490	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
Reut_A0492	COG0006	proline dipeptidase activity
Reut_A0493	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
Reut_A0496	COG3178	'Phosphotransferase
Reut_A0503	COG0346	lactoylglutathione lyase activity
Reut_A0505	COG0204	Acyl-transferase
Reut_A0506	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
Reut_A0507	COG0751	glycine-tRNA ligase activity
Reut_A0509	COG0752	glycyl-tRNA synthetase alpha subunit
Reut_A0510	COG0815	Transfers the fatty acyl group on membrane lipoproteins
Reut_A0513	COG1702	phosphate starvation-inducible protein PhoH
Reut_A0516	COG0038	chloride channel
Reut_A0517	COG0513	Belongs to the DEAD box helicase family
Reut_A0518	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
Reut_A0521	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
Reut_A0525	COG0642	Histidine kinase
Reut_A0528	COG2137	regulation of response to DNA damage stimulus
Reut_A0531	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
Reut_A0532	COG0861	Integral membrane protein TerC family
Reut_A0533	COG4969	Belongs to the N-Me-Phe pilin family
Reut_A0537	COG1278	Cold shock
Reut_A0539	COG3706	GGDEF domain
Reut_A0539	COG0745	RESPONSE REGULATOR receiver
Reut_A0541	COG4783	chaperone-mediated protein folding
Reut_A0543	COG0429	hydrolase of the alpha beta-hydrolase fold
Reut_A0545	COG0859	PFAM glycosyl transferase family 9
Reut_A0547	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
Reut_A0553	COG0009	L-threonylcarbamoyladenylate synthase
Reut_A0554	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
Reut_A0555	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
Reut_A0558	COG0469	pyruvate kinase activity
Reut_A0559	COG0126	phosphoglycerate kinase activity
Reut_A0567	COG0583	DNA-binding transcription factor activity
Reut_A0568	COG3328	transposase activity
Reut_A0570	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
Reut_A0571	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
Reut_A0573	COG0745	RESPONSE REGULATOR receiver
Reut_A0574	COG2205	protein histidine kinase activity
Reut_A0577	COG4974	Belongs to the 'phage' integrase family
Reut_A0578	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
Reut_A0582	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
Reut_A0583	COG0802	atpase or kinase
Reut_A0584	COG0860	N-Acetylmuramoyl-L-alanine amidase
Reut_A0586	COG0583	DNA-binding transcription factor activity
Reut_A0587	COG2226	methyltransferase
Reut_A0595	COG0811	peptide transport
Reut_A0597	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
Reut_A0603	COG5592	hemerythrin HHE cation binding domain
Reut_A0607	COG2201	protein-glutamate methylesterase activity
Reut_A0608	COG1058	Belongs to the CinA family
Reut_A0608	COG1546	Belongs to the CinA family
Reut_A0615	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
Reut_A0616	COG1910	domain protein
Reut_A0619	COG3383	formate dehydrogenase (NAD+) activity
Reut_A0620	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
Reut_A0622	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
Reut_A0624	COG2365	Tyrosine phosphatase family
Reut_A0625	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
Reut_A0628	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
Reut_A0632	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
Reut_A0633	COG4149	molybdate abc transporter
Reut_A0634	COG0725	ABC transporter, periplasmic molybdate-binding protein
Reut_A0636	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
Reut_A0638	COG3328	transposase activity
Reut_A0640	COG0583	DNA-binding transcription factor activity
Reut_A0644	COG1802	Transcriptional regulator
Reut_A0647	COG1024	Enoyl-CoA hydratase
Reut_A0648	COG0318	PFAM AMP-dependent synthetase and ligase
Reut_A0650	COG0730	response to heat
Reut_A0654	COG4206	TonB-dependent receptor
Reut_A0655	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Reut_A0656	COG1120	ATPase activity
Reut_A0658	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
Reut_A0659	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
Reut_A0661	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
Reut_A0669	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
Reut_A0675	COG2885	chlorophyll binding
Reut_A0675	COG3047	cAMP biosynthetic process
Reut_A0676	COG0489	protein tyrosine kinase activity
Reut_A0682	COG0243	molybdopterin cofactor binding
Reut_A0682	COG3383	formate dehydrogenase (NAD+) activity
Reut_A0683	COG0437	4 iron, 4 sulfur cluster binding
Reut_A0687	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
Reut_A0689	COG1982	Orn Lys Arg decarboxylase major
Reut_A0691	COG0438	transferase activity, transferring glycosyl groups
Reut_A0699	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
Reut_A0700	COG0181	hydroxymethylbilane synthase activity
Reut_A0701	COG1587	Uroporphyrinogen-III synthase
Reut_A0703	COG0415	Belongs to the DNA photolyase family
Reut_A0707	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
Reut_A0709	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
Reut_A0711	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
Reut_A0712	COG1088	dTDP-glucose 4,6-dehydratase activity
Reut_A0714	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
Reut_A0716	COG1682	transport, permease protein
Reut_A0718	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
Reut_A0719	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Reut_A0721	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
Reut_A0722	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
Reut_A0723	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
Reut_A0725	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
Reut_A0739	COG0529	Catalyzes the synthesis of activated sulfate
Reut_A0740	COG0438	transferase activity, transferring glycosyl groups
Reut_A0742	COG0297	glycogen (starch) synthase activity
Reut_A0743	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
Reut_A0751	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
Reut_A0764	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
Reut_A0766	COG0741	lytic transglycosylase activity
Reut_A0767	COG0436	Aminotransferase
Reut_A0776	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
Reut_A0776	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
Reut_A0791	COG0824	Thioesterase
Reut_A0796	COG2885	chlorophyll binding
Reut_A0799	COG2391	methyltransferase activity
Reut_A0800	COG5002	protein histidine kinase activity
Reut_A0800	COG5001	Diguanylate cyclase
Reut_A0800	COG3447	MASE1 domain protein
Reut_A0807	COG3483	tryptophan 2,3-dioxygenase activity
Reut_A0810	COG1522	sequence-specific DNA binding
Reut_A0811	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
Reut_A0812	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
Reut_A0814	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
Reut_A0817	COG2982	Protein involved in outer membrane biogenesis
Reut_A0818	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
Reut_A0822	COG3118	belongs to the thioredoxin family
Reut_A0823	COG0318	PFAM AMP-dependent synthetase and ligase
Reut_A0825	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
Reut_A0828	COG4681	YaeQ
Reut_A0833	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
Reut_A0835	COG2808	Putative FMN-binding domain
Reut_A0839	COG3121	Chaperone
Reut_A0843	COG0583	DNA-binding transcription factor activity
Reut_A0846	COG3263	regulation of cellular component size
Reut_A0849	COG1804	L-carnitine dehydratase bile acid-inducible protein F
Reut_A0852	COG0330	HflC and HflK could
Reut_A0855	COG1942	4-Oxalocrotonate Tautomerase
Reut_A0856	COG0477	Major facilitator Superfamily
Reut_A0857	COG0235	Class ii aldolase
Reut_A0858	COG1942	4-Oxalocrotonate Tautomerase
Reut_A0861	COG0425	Belongs to the sulfur carrier protein TusA family
Reut_A0862	COG1210	Utp--glucose-1-phosphate uridylyltransferase
Reut_A0864	COG0210	DNA helicase
Reut_A0865	COG2271	Major facilitator Superfamily
Reut_A0866	COG0318	PFAM AMP-dependent synthetase and ligase
Reut_A0867	COG1012	belongs to the aldehyde dehydrogenase family
Reut_A0868	COG1414	Transcriptional regulator
Reut_A0872	COG1611	Belongs to the LOG family
Reut_A0873	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
Reut_A0873	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
Reut_A0874	COG1252	NADH dehydrogenase
Reut_A0875	COG0412	Dienelactone hydrolase
Reut_A0880	COG1722	exodeoxyribonuclease VII activity
Reut_A0881	COG0142	geranyltranstransferase activity
Reut_A0885	COG2081	HI0933 family
Reut_A0886	COG1610	YqeY-like protein
Reut_A0887	COG0358	DNA primase activity
Reut_A0888	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
Reut_A0889	COG0477	Major facilitator Superfamily
Reut_A0890	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
Reut_A0892	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
Reut_A0896	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
Reut_A0899	COG0513	Belongs to the DEAD box helicase family
Reut_A0900	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
Reut_A0901	COG0583	DNA-binding transcription factor activity
Reut_A0902	COG1741	Belongs to the pirin family
Reut_A0903	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
Reut_A0905	COG1162	GTPase activity
Reut_A0906	COG0501	Belongs to the peptidase M48B family
Reut_A0907	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
Reut_A0909	COG0521	Mo-molybdopterin cofactor biosynthetic process
Reut_A0911	COG0312	modulator of DNA gyrase
Reut_A0915	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
Reut_A0916	COG0861	Integral membrane protein TerC family
Reut_A0918	COG1262	PFAM Formylglycine-generating sulfatase enzyme
Reut_A0919	COG0513	Belongs to the DEAD box helicase family
Reut_A0922	COG1262	PFAM Formylglycine-generating sulfatase enzyme
Reut_A0925	COG1538	Outer membrane efflux protein
Reut_A0928	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
Reut_A0930	COG2204	response regulator
Reut_A0934	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
Reut_A0940	COG0438	transferase activity, transferring glycosyl groups
Reut_A0947	COG0028	Belongs to the TPP enzyme family
Reut_A0948	COG0440	acetolactate synthase activity
Reut_A0951	COG1183	phosphatidylcholine synthase activity
Reut_A0952	COG1652	LysM domain
Reut_A0955	COG0683	leucine binding
Reut_A0967	COG1034	ATP synthesis coupled electron transport
Reut_A0974	COG1007	ATP synthesis coupled electron transport
Reut_A0978	COG1960	acyl-CoA dehydrogenase activity
Reut_A0980	COG2030	dehydratase
Reut_A0980	COG1012	belongs to the aldehyde dehydrogenase family
Reut_A0982	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
Reut_A0989	COG0411	ABC transporter
Reut_A1001	COG0625	glutathione transferase activity
Reut_A1002	COG1960	acyl-CoA dehydrogenase activity
Reut_A1005	COG0405	Gamma-glutamyltransferase
Reut_A1006	COG3181	Tripartite tricarboxylate transporter family receptor
Reut_A1009	COG1024	Enoyl-CoA hydratase
Reut_A1010	COG1250	3-hydroxyacyl-CoA dehydrogenase
Reut_A1011	COG0625	glutathione transferase activity
Reut_A1012	COG0436	Aminotransferase
Reut_A1015	COG2866	Carboxypeptidase
Reut_A1018	COG3181	Tripartite tricarboxylate transporter family receptor
Reut_A1026	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
Reut_A1027	COG0312	modulator of DNA gyrase
Reut_A1028	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
Reut_A1030	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
Reut_A1034	COG0497	DNA recombination
Reut_A1036	COG1420	regulation of RNA biosynthetic process
Reut_A1042	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
Reut_A1045	COG0778	Nitroreductase
Reut_A1046	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
Reut_A1047	COG2878	Part of a membrane complex involved in electron transport
Reut_A1048	COG1309	transcriptional regulator
Reut_A1058	COG1104	cysteine desulfurase activity
Reut_A1059	COG0822	iron-sulfur transferase activity
Reut_A1060	COG0316	Belongs to the HesB IscA family
Reut_A1062	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
Reut_A1069	COG1131	(ABC) transporter
Reut_A1071	COG1028	Short-chain dehydrogenase reductase Sdr
Reut_A1072	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
Reut_A1073	COG4942	peptidase
Reut_A1074	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
Reut_A1078	COG0084	hydrolase, TatD family'
Reut_A1082	COG3265	gluconokinase activity
Reut_A1083	COG2308	Evidence 4 Homologs of previously reported genes of
Reut_A1087	COG2267	carboxylic ester hydrolase activity
Reut_A1094	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
Reut_A1096	COG2833	Protein of unknown function (DUF455)
Reut_A1097	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
Reut_A1098	COG2267	carboxylic ester hydrolase activity
Reut_A1100	COG0613	PHP domain protein
Reut_A1101	COG0009	L-threonylcarbamoyladenylate synthase
Reut_A1102	COG1994	Peptidase M50
Reut_A1104	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
Reut_A1105	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
Reut_A1106	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
Reut_A1108	COG2850	peptidyl-arginine hydroxylation
Reut_A1112	COG0589	response to stress
Reut_A1114	COG2841	Protein conserved in bacteria
Reut_A1117	COG1045	serine acetyltransferase
Reut_A1118	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
Reut_A1120	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
Reut_A1123	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
Reut_A1125	COG0037	tRNA processing
Reut_A1126	COG0527	aspartate kinase activity
Reut_A1127	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Reut_A1130	COG0583	DNA-binding transcription factor activity
Reut_A1131	COG0778	Nitroreductase
Reut_A1135	COG0179	Fumarylacetoacetate (FAA) hydrolase
Reut_A1137	COG0346	lactoylglutathione lyase activity
Reut_A1144	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
Reut_A1147	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
Reut_A1149	COG0071	Belongs to the small heat shock protein (HSP20) family
Reut_A1150	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
Reut_A1150	COG0517	IMP dehydrogenase activity
Reut_A1162	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
Reut_A1162	COG0574	Belongs to the PEP-utilizing enzyme family
Reut_A1163	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
Reut_A1168	COG0686	Belongs to the AlaDH PNT family
Reut_A1175	COG1234	tRNA 3'-trailer cleavage
Reut_A1177	COG1881	PFAM PEBP family protein
Reut_A1184	COG0589	response to stress
Reut_A1187	COG3258	Cytochrome c
Reut_A1188	COG3258	Cytochrome c
Reut_A1191	COG3181	Tripartite tricarboxylate transporter family receptor
Reut_A1192	COG1028	Short-chain dehydrogenase reductase Sdr
Reut_A1196	COG0318	PFAM AMP-dependent synthetase and ligase
Reut_A1198	COG1609	Transcriptional regulator
Reut_A1203	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
Reut_A1213	COG0589	response to stress
Reut_A1214	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
Reut_A1217	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
Reut_A1219	COG0071	Belongs to the small heat shock protein (HSP20) family
Reut_A1221	COG4876	unkown
Reut_A1223	COG1136	(ABC) transporter
Reut_A1234	COG2217	Heavy metal translocating P-type atpase
Reut_A1238	COG3387	PFAM Glycoside hydrolase 15-related
Reut_A1240	COG0747	negative chemotaxis
Reut_A1241	COG0601	transmembrane transport
Reut_A1244	COG4608	Belongs to the ABC transporter superfamily
Reut_A1245	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
Reut_A1247	COG0277	FAD linked oxidase domain protein
Reut_A1250	COG1295	ribonuclease BN
Reut_A1252	COG2267	carboxylic ester hydrolase activity
Reut_A1255	COG0477	Major facilitator Superfamily
Reut_A1258	COG2814	Major facilitator Superfamily
Reut_A1259	COG0579	oxidoreductase
Reut_A1260	COG2186	Transcriptional regulator
Reut_A1263	COG1028	Short-chain dehydrogenase reductase Sdr
Reut_A1266	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
Reut_A1271	COG1028	Short-chain dehydrogenase reductase Sdr
Reut_A1272	COG2267	carboxylic ester hydrolase activity
Reut_A1273	COG0251	oxidation-reduction process
Reut_A1274	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
Reut_A1278	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
Reut_A1281	COG0776	regulation of translation
Reut_A1288	COG2902	Dehydrogenase
Reut_A1290	COG0427	acetyl-CoA hydrolase
Reut_A1298	COG0339	signal peptide processing
Reut_A1301	COG4566	intracellular signal transduction
Reut_A1303	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
Reut_A1304	COG0508	dehydrogenase complex catalyzes the overall conversion of
Reut_A1306	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
Reut_A1308	COG2186	Transcriptional regulator
Reut_A1309	COG1414	Transcriptional regulator
Reut_A1310	COG0247	lactate metabolic process
Reut_A1313	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
Reut_A1316	COG0667	Aldo Keto reductase
Reut_A1331	COG1172	Belongs to the binding-protein-dependent transport system permease family
Reut_A1335	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Reut_A1335	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
Reut_A1336	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
Reut_A1337	COG0745	RESPONSE REGULATOR receiver
Reut_A1338	COG0642	Histidine kinase
Reut_A1339	COG2183	response to ionizing radiation
Reut_A1342	COG1199	ATP-dependent helicase activity
Reut_A1344	COG0564	pseudouridine synthase activity
Reut_A1347	COG3243	poly(R)-hydroxyalkanoic acid synthase
Reut_A1348	COG0183	Belongs to the thiolase family
Reut_A1349	COG1028	Short-chain dehydrogenase reductase Sdr
Reut_A1351	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
Reut_A1353	COG0183	Belongs to the thiolase family
Reut_A1355	COG0626	cystathionine gamma-synthase activity
Reut_A1357	COG0560	Phosphoserine phosphatase
Reut_A1360	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
Reut_A1364	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
Reut_A1365	COG0450	alkyl hydroperoxide reductase
Reut_A1367	COG2205	protein histidine kinase activity
Reut_A1368	COG0745	RESPONSE REGULATOR receiver
Reut_A1377	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
Reut_A1382	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
Reut_A1385	COG4181	ATPase activity
Reut_A1390	COG0047	phosphoribosylformylglycinamidine synthase activity
Reut_A1390	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
Reut_A1392	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
Reut_A1394	COG2917	probably involved in intracellular septation
Reut_A1395	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
Reut_A1398	COG0318	PFAM AMP-dependent synthetase and ligase
Reut_A1400	COG0559	Belongs to the binding-protein-dependent transport system permease family
Reut_A1402	COG0411	ABC transporter
Reut_A1403	COG0410	ABC transporter
Reut_A1404	COG0833	amino acid
Reut_A1405	COG1250	3-hydroxyacyl-CoA dehydrogenase
Reut_A1405	COG1024	Enoyl-CoA hydratase
Reut_A1406	COG1335	isochorismatase
Reut_A1407	COG0183	Belongs to the thiolase family
Reut_A1408	COG1960	acyl-CoA dehydrogenase activity
Reut_A1412	COG2130	NADP-dependent
Reut_A1414	COG4221	oxidoreductase activity
Reut_A1416	COG0596	Alpha beta hydrolase
Reut_A1418	COG1454	alcohol dehydrogenase
Reut_A1422	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Reut_A1423	COG3622	Belongs to the hyi family
Reut_A1424	COG2271	Major facilitator Superfamily
Reut_A1425	COG0235	Class ii aldolase
Reut_A1426	COG3395	kinase activity
Reut_A1427	COG2084	Dehydrogenase
Reut_A1428	COG2186	Transcriptional regulator
Reut_A1433	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
Reut_A1437	COG0084	hydrolase, TatD family'
Reut_A1440	COG1262	PFAM Formylglycine-generating sulfatase enzyme
Reut_A1442	COG0583	DNA-binding transcription factor activity
Reut_A1445	COG1674	ftsk spoiiie
Reut_A1449	COG2072	flavoprotein involved in K transport
Reut_A1455	COG0435	Glutathione S-transferase
Reut_A1456	COG0204	Acyl-transferase
Reut_A1458	COG3284	Transcriptional regulator
Reut_A1465	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
Reut_A1466	COG1960	acyl-CoA dehydrogenase activity
Reut_A1467	COG0318	PFAM AMP-dependent synthetase and ligase
Reut_A1470	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
Reut_A1472	COG4521	taurine ABC transporter
Reut_A1478	COG1012	belongs to the aldehyde dehydrogenase family
Reut_A1480	COG0583	DNA-binding transcription factor activity
Reut_A1486	COG0625	glutathione transferase activity
Reut_A1489	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
Reut_A1497	COG0028	Belongs to the TPP enzyme family
Reut_A1498	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
Reut_A1499	COG3836	Belongs to the HpcH HpaI aldolase family
Reut_A1500	COG2084	Dehydrogenase
Reut_A1505	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
Reut_A1507	COG0583	DNA-binding transcription factor activity
Reut_A1509	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
Reut_A1512	COG1028	Short-chain dehydrogenase reductase Sdr
Reut_A1515	COG1309	transcriptional regulator
Reut_A1525	COG1393	Belongs to the ArsC family
Reut_A1526	COG0798	PFAM Bile acid sodium symporter
Reut_A1534	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
Reut_A1542	COG1960	acyl-CoA dehydrogenase activity
Reut_A1544	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
Reut_A1549	COG1028	Short-chain dehydrogenase reductase Sdr
Reut_A1551	COG1028	Short-chain dehydrogenase reductase Sdr
Reut_A1554	COG1028	Short-chain dehydrogenase reductase Sdr
Reut_A1560	COG1024	Enoyl-CoA hydratase
Reut_A1562	COG1024	Enoyl-CoA hydratase
Reut_A1563	COG1960	acyl-CoA dehydrogenase activity
Reut_A1564	COG1960	acyl-CoA dehydrogenase activity
Reut_A1565	COG0183	Belongs to the thiolase family
Reut_A1567	COG1028	Short-chain dehydrogenase reductase Sdr
Reut_A1569	COG1960	acyl-CoA dehydrogenase activity
Reut_A1572	COG0183	Belongs to the thiolase family
Reut_A1575	COG1902	pentaerythritol trinitrate reductase activity
Reut_A1575	COG0446	pyridine nucleotide-disulphide oxidoreductase
Reut_A1577	COG1028	Short-chain dehydrogenase reductase Sdr
Reut_A1582	COG0196	riboflavin kinase activity
Reut_A1583	COG0583	DNA-binding transcription factor activity
Reut_A1587	COG3485	protocatechuate 3,4-dioxygenase
Reut_A1593	COG0765	amino acid transport
Reut_A1594	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Reut_A1597	COG3246	L-lysine catabolic process to acetate
Reut_A1599	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
Reut_A1600	COG1028	Short-chain dehydrogenase reductase Sdr
Reut_A1601	COG3246	L-lysine catabolic process to acetate
Reut_A1602	COG2175	clavaminate synthase activity
Reut_A1606	COG2207	Transcriptional regulator
Reut_A1608	COG0583	DNA-binding transcription factor activity
Reut_A1614	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Reut_A1617	COG2169	Transcriptional regulator
Reut_A1618	COG2814	Major facilitator Superfamily
Reut_A1619	COG0154	amidase activity
Reut_A1620	COG2814	Major facilitator Superfamily
Reut_A1624	COG0076	glutamate decarboxylase activity
Reut_A1625	COG0582	viral genome integration into host DNA
Reut_A1629	COG3550	peptidyl-serine autophosphorylation
Reut_A1631	COG3246	L-lysine catabolic process to acetate
Reut_A1637	COG0277	FAD linked oxidase domain protein
Reut_A1644	COG0583	DNA-binding transcription factor activity
Reut_A1645	COG4178	(ABC) transporter
Reut_A1650	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
Reut_A1652	COG1172	Belongs to the binding-protein-dependent transport system permease family
Reut_A1655	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
Reut_A1658	COG0154	amidase activity
Reut_A1661	COG1304	FMN binding
Reut_A1663	COG0583	DNA-binding transcription factor activity
Reut_A1664	COG3181	Tripartite tricarboxylate transporter family receptor
Reut_A1665	COG2175	clavaminate synthase activity
Reut_A1667	COG1024	Enoyl-CoA hydratase
Reut_A1671	COG1024	Enoyl-CoA hydratase
Reut_A1672	COG3181	Tripartite tricarboxylate transporter family receptor
Reut_A1673	COG1804	L-carnitine dehydratase bile acid-inducible protein F
Reut_A1674	COG3181	Tripartite tricarboxylate transporter family receptor
Reut_A1677	COG4943	cyclic-guanylate-specific phosphodiesterase activity
Reut_A1678	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
Reut_A1678	COG2111	Na H antiporter
Reut_A1679	COG1006	Multisubunit Na H antiporter MnhC subunit
Reut_A1680	COG0651	ATP synthesis coupled electron transport
Reut_A1681	COG1863	multisubunit Na H antiporter MnhE subunit
Reut_A1682	COG2212	antiporter activity
Reut_A1685	COG0840	transmembrane signaling receptor activity
Reut_A1687	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Reut_A1689	COG4948	Mandelate Racemase Muconate Lactonizing
Reut_A1692	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
Reut_A1693	COG2197	response regulator
Reut_A1695	COG3121	Chaperone
Reut_A1704	COG2871	sodium ion transport
Reut_A1709	COG2814	Major facilitator Superfamily
Reut_A1712	COG2801	Transposase and inactivated derivatives
Reut_A1719	COG1823	symporter activity
Reut_A1721	COG1301	dicarboxylic acid transport
Reut_A1726	COG3501	Rhs element vgr protein
Reut_A1734	COG2197	response regulator
Reut_A1746	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
Reut_A1749	COG3706	GGDEF domain
Reut_A1750	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
Reut_A1752	COG0443	Heat shock 70 kDa protein
Reut_A1753	COG0443	Heat shock 70 kDa protein
Reut_A1756	COG0516	GMP reductase activity
Reut_A1756	COG0517	IMP dehydrogenase activity
Reut_A1757	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
Reut_A1761	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
Reut_A1762	COG1028	Short-chain dehydrogenase reductase Sdr
Reut_A1770	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
Reut_A1770	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
Reut_A1775	COG0165	Argininosuccinate lyase
Reut_A1778	COG3284	Transcriptional regulator
Reut_A1779	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
Reut_A1780	COG5424	Ring cyclization and eight-electron oxidation of 3a-(2- amino-2-carboxyethyl)-4,5-dioxo-4,5,6,7,8,9-hexahydroquinoline- 7,9-dicarboxylic-acid to PQQ
Reut_A1782	COG0535	radical SAM domain protein
Reut_A1783	COG4654	Cytochrome c, class I
Reut_A1785	COG2197	response regulator
Reut_A1790	COG1595	DNA-templated transcription, initiation
Reut_A1791	COG1027	Aspartate ammonia-lyase
Reut_A1801	COG0668	transmembrane transport
Reut_A1806	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
Reut_A1820	COG1804	L-carnitine dehydratase bile acid-inducible protein F
Reut_A1821	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
Reut_A1823	COG2814	Major facilitator Superfamily
Reut_A1824	COG1073	alpha beta
Reut_A1825	COG1063	alcohol dehydrogenase
Reut_A1827	COG1804	L-carnitine dehydratase bile acid-inducible protein F
Reut_A1828	COG1028	Short-chain dehydrogenase reductase Sdr
Reut_A1829	COG1804	L-carnitine dehydratase bile acid-inducible protein F
Reut_A1830	COG1804	L-carnitine dehydratase bile acid-inducible protein F
Reut_A1831	COG3181	Tripartite tricarboxylate transporter family receptor
Reut_A1834	COG1012	belongs to the aldehyde dehydrogenase family
Reut_A1834	COG2030	dehydratase
Reut_A1835	COG1960	acyl-CoA dehydrogenase activity
Reut_A1836	COG0583	DNA-binding transcription factor activity
Reut_A1839	COG2258	MOSC domain
Reut_A1844	COG0488	(ABC) transporter
Reut_A1845	COG1619	proteins homologs of microcin C7 resistance protein MccF
Reut_A1846	COG0590	tRNA wobble adenosine to inosine editing
Reut_A1847	COG0720	synthase
Reut_A1848	COG0602	queuosine metabolic process
Reut_A1849	COG2814	Major facilitator Superfamily
Reut_A1853	COG1201	RNA secondary structure unwinding
Reut_A1860	COG2867	negative regulation of translational initiation
Reut_A1862	COG0330	HflC and HflK could
Reut_A1874	COG0750	zinc metalloprotease
Reut_A1876	COG0575	Belongs to the CDS family
Reut_A1877	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
Reut_A1882	COG0024	Methionine aminopeptidase
Reut_A1884	COG1187	pseudouridine synthase activity
Reut_A1885	COG0242	peptide deformylase activity
Reut_A1894	COG1393	Belongs to the ArsC family
Reut_A1896	COG2890	protein-(glutamine-N5) methyltransferase activity
Reut_A1901	COG0300	oxidoreductase activity
Reut_A1902	COG0583	DNA-binding transcription factor activity
Reut_A1904	COG1024	Enoyl-CoA hydratase
Reut_A1906	COG1024	Enoyl-CoA hydratase
Reut_A1907	COG0045	succinate-CoA ligase (ADP-forming) activity
Reut_A1907	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
Reut_A1907	COG1042	CoA-binding domain protein
Reut_A1909	COG0583	DNA-binding transcription factor activity
Reut_A1910	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
Reut_A1914	COG1335	isochorismatase
Reut_A1924	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
Reut_A1925	COG0601	transmembrane transport
Reut_A1926	COG0747	negative chemotaxis
Reut_A1927	COG4172	Belongs to the ABC transporter superfamily
Reut_A1930	COG0488	(ABC) transporter
Reut_A1934	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
Reut_A1935	COG0477	Major facilitator Superfamily
Reut_A1937	COG1573	uracil-dna glycosylase
Reut_A1939	COG1214	PFAM Peptidase M22, glycoprotease
Reut_A1941	COG2814	Major facilitator Superfamily
Reut_A1948	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
Reut_A1951	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
Reut_A1953	COG0583	DNA-binding transcription factor activity
Reut_A1954	COG0589	response to stress
Reut_A1958	COG0643	Histidine kinase
Reut_A1958	COG2198	Histidine kinase
Reut_A1960	COG0501	Belongs to the peptidase M48B family
Reut_A1961	COG2224	Isocitrate lyase
Reut_A1966	COG2972	Histidine kinase
Reut_A1967	COG0583	DNA-binding transcription factor activity
Reut_A1968	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
Reut_A1969	COG4208	sulfate ABC transporter
Reut_A1970	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
Reut_A1975	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
Reut_A1977	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
Reut_A1978	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
Reut_A1980	COG0542	response to heat
Reut_A1984	COG0410	ABC transporter
Reut_A1985	COG0411	ABC transporter
Reut_A1989	COG0314	molybdopterin synthase activity
Reut_A1990	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
Reut_A1991	COG0303	'Molybdopterin
Reut_A1994	COG0436	Aminotransferase
Reut_A1996	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
Reut_A1997	COG1875	ATPase related to phosphate starvation-inducible protein PhoH
Reut_A1999	COG0791	NLP P60 protein
Reut_A2000	COG0306	phosphate transporter
Reut_A2002	COG0305	Participates in initiation and elongation during chromosome replication
Reut_A2007	COG0252	asparaginase activity
Reut_A2017	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
Reut_A2018	COG0431	NADPH-dependent FMN reductase
Reut_A2019	COG1024	Enoyl-CoA hydratase
Reut_A2020	COG0840	transmembrane signaling receptor activity
Reut_A2022	COG1846	Transcriptional regulator
Reut_A2024	COG1566	PFAM secretion protein HlyD family protein
Reut_A2025	COG2814	Major facilitator Superfamily
Reut_A2029	COG2251	uridine kinase activity
Reut_A2029	COG0195	Participates in both transcription termination and antitermination
Reut_A2031	COG1187	pseudouridine synthase activity
Reut_A2032	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
Reut_A2034	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
Reut_A2041	COG3278	Belongs to the heme-copper respiratory oxidase family
Reut_A2043	COG2217	Heavy metal translocating P-type atpase
Reut_A2044	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
Reut_A2045	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
Reut_A2046	COG0508	dehydrogenase complex catalyzes the overall conversion of
Reut_A2047	COG0567	Dehydrogenase, E1 component
Reut_A2048	COG0584	glycerophosphoryl diester phosphodiesterase
Reut_A2051	COG1175	transmembrane transport
Reut_A2052	COG1653	transport
Reut_A2054	COG2204	response regulator
Reut_A2055	COG3852	Histidine kinase
Reut_A2060	COG1058	Belongs to the CinA family
Reut_A2060	COG1546	Belongs to the CinA family
Reut_A2065	COG1643	Atp-dependent helicase
Reut_A2066	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
Reut_A2066	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
Reut_A2070	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
Reut_A2071	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
Reut_A2072	COG0557	exoribonuclease II activity
Reut_A2074	COG2910	NAD(P)H-binding
Reut_A2075	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
Reut_A2078	COG0330	HflC and HflK could
Reut_A2079	COG0330	HflC and HflK could
Reut_A2080	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
Reut_A2086	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
Reut_A2091	COG0670	Belongs to the BI1 family
Reut_A2099	COG0604	alcohol dehydrogenase
Reut_A2099	COG1028	Short-chain dehydrogenase reductase Sdr
Reut_A2099	COG3321	synthase
Reut_A2102	COG0642	Histidine kinase
Reut_A2103	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
Reut_A2105	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
Reut_A2106	COG3181	Tripartite tricarboxylate transporter family receptor
Reut_A2107	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Reut_A2108	COG1804	L-carnitine dehydratase bile acid-inducible protein F
Reut_A2112	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
Reut_A2113	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
Reut_A2114	COG1074	ATP-dependent DNA helicase activity
Reut_A2118	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
Reut_A2122	COG0534	Mate efflux family protein
Reut_A2124	COG1752	Esterase of the alpha-beta hydrolase superfamily
Reut_A2125	COG0791	NLP P60 protein
Reut_A2126	COG4172	Belongs to the ABC transporter superfamily
Reut_A2127	COG4239	(ABC) transporter, permease
Reut_A2128	COG4174	ABC transporter (Permease)
Reut_A2134	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
Reut_A2140	COG1960	acyl-CoA dehydrogenase activity
Reut_A2143	COG3246	L-lysine catabolic process to acetate
Reut_A2146	COG0318	PFAM AMP-dependent synthetase and ligase
Reut_A2147	COG2175	clavaminate synthase activity
Reut_A2157	COG2062	phosphohistidine phosphatase, SixA
Reut_A2159	COG0248	Ppx GppA phosphatase
Reut_A2160	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
Reut_A2162	COG0745	RESPONSE REGULATOR receiver
Reut_A2165	COG0581	inorganic phosphate transmembrane transporter activity
Reut_A2166	COG0573	inorganic phosphate transmembrane transporter activity
Reut_A2167	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
Reut_A2170	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
Reut_A2172	COG1534	Rna-binding protein
Reut_A2174	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
Reut_A2175	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
Reut_A2177	COG0505	Belongs to the CarA family
Reut_A2182	COG1024	Enoyl-CoA hydratase
Reut_A2183	COG1028	Short-chain dehydrogenase reductase Sdr
Reut_A2185	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
Reut_A2186	COG0741	lytic transglycosylase activity
Reut_A2186	COG1388	LysM domain
Reut_A2190	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
Reut_A2191	COG0582	viral genome integration into host DNA
Reut_A2200	COG3328	transposase activity
Reut_A2206	COG0395	ABC-type sugar transport system, permease component
Reut_A2209	COG3842	ATPase activity
Reut_A2213	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
Reut_A2214	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
Reut_A2215	COG3895	Periplasmic Protein
Reut_A2222	COG2199	diguanylate cyclase activity
Reut_A2223	COG2885	chlorophyll binding
Reut_A2228	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
Reut_A2230	COG0697	spore germination
Reut_A2234	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
Reut_A2239	COG3193	protein, possibly involved in utilization of glycolate and propanediol
Reut_A2241	COG2855	membrane
Reut_A2242	COG0583	DNA-binding transcription factor activity
Reut_A2247	COG1472	Belongs to the glycosyl hydrolase 3 family
Reut_A2251	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
Reut_A2254	COG0681	Belongs to the peptidase S26 family
Reut_A2256	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Reut_A2261	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
Reut_A2262	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
Reut_A2263	COG1028	Short-chain dehydrogenase reductase Sdr
Reut_A2264	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
Reut_A2267	COG0333	Belongs to the bacterial ribosomal protein bL32 family
Reut_A2274	COG0564	pseudouridine synthase activity
Reut_A2275	COG1530	ribonuclease E activity
Reut_A2276	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
Reut_A2284	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
Reut_A2286	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
Reut_A2289	COG0745	RESPONSE REGULATOR receiver
Reut_A2290	COG2205	protein histidine kinase activity
Reut_A2291	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
Reut_A2292	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
Reut_A2293	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
Reut_A2294	COG0828	Belongs to the bacterial ribosomal protein bS21 family
Reut_A2300	COG1286	toxin biosynthetic process
Reut_A2302	COG0285	dihydrofolate synthase activity
Reut_A2303	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
Reut_A2306	COG0133	tryptophan synthase activity
Reut_A2307	COG0135	phosphoribosylanthranilate isomerase activity
Reut_A2310	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
Reut_A2315	COG0410	ABC transporter
Reut_A2320	COG0372	Belongs to the citrate synthase family
Reut_A2321	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
Reut_A2322	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
Reut_A2323	COG1053	succinate dehydrogenase
Reut_A2324	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
Reut_A2326	COG2188	Transcriptional regulator
Reut_A2331	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
Reut_A2334	COG0220	tRNA (guanine-N7-)-methyltransferase activity
Reut_A2343	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
Reut_A2345	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
Reut_A2347	COG0697	spore germination
Reut_A2350	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
Reut_A2351	COG0625	glutathione transferase activity
Reut_A2352	COG1280	lysine exporter protein (LysE YggA)
Reut_A2353	COG1620	l-lactate permease
Reut_A2362	COG3135	benzoate transporter
Reut_A2365	COG0582	viral genome integration into host DNA
Reut_A2374	COG0419	ATPase involved in DNA repair
Reut_A2375	COG1674	ftsk spoiiie
Reut_A2375	COG0531	amino acid
Reut_A2384	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
Reut_A2388	COG5410	chromosome segregation
Reut_A2426	COG1529	Aldehyde oxidase and xanthine dehydrogenase
Reut_A2429	COG0402	S-adenosylhomocysteine deaminase activity
Reut_A2431	COG2119	membrane
Reut_A2434	COG2351	hydroxyisourate hydrolase activity
Reut_A2436	COG2233	PERMEase
Reut_A2438	COG3648	Uricase
Reut_A2438	COG3195	allantoin biosynthetic process
Reut_A2441	COG0280	phosphate acetyltransferase
Reut_A2441	COG0281	malic enzyme
Reut_A2443	COG0308	aminopeptidase N
Reut_A2450	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
Reut_A2451	COG4770	biotin carboxylase activity
Reut_A2452	COG0840	transmembrane signaling receptor activity
Reut_A2459	COG2509	5-formyltetrahydrofolate cyclo-ligase activity
Reut_A2460	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
Reut_A2471	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
Reut_A2472	COG1758	RNA polymerase activity
Reut_A2474	COG1561	YicC-like family, N-terminal region
Reut_A2475	COG4991	sh3 domain protein
Reut_A2475	COG0515	serine threonine protein kinase
Reut_A2475	COG3064	Membrane
Reut_A2477	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
Reut_A2478	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
Reut_A2479	COG0635	Involved in the biosynthesis of porphyrin-containing compound
Reut_A2482	COG0492	ferredoxin-NADP+ reductase activity
Reut_A2483	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
Reut_A2484	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
Reut_A2489	COG2132	Multicopper oxidase
Reut_A2490	COG0745	RESPONSE REGULATOR receiver
Reut_A2491	COG5002	protein histidine kinase activity
Reut_A2497	COG1741	Belongs to the pirin family
Reut_A2505	COG1028	Short-chain dehydrogenase reductase Sdr
Reut_A2506	COG0697	spore germination
Reut_A2508	COG1846	Transcriptional regulator
Reut_A2509	COG1529	Aldehyde oxidase and xanthine dehydrogenase
Reut_A2509	COG2010	Cytochrome c
Reut_A2510	COG1309	transcriptional regulator
Reut_A2511	COG1335	isochorismatase
Reut_A2512	COG2309	aminopeptidase activity
Reut_A2513	COG0596	Alpha beta hydrolase
Reut_A2514	COG3473	Maleate cis-trans isomerase
Reut_A2516	COG2080	2 iron, 2 sulfur cluster binding
Reut_A2517	COG2010	Cytochrome c
Reut_A2517	COG1529	Aldehyde oxidase and xanthine dehydrogenase
Reut_A2518	COG0477	Major facilitator Superfamily
Reut_A2519	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
Reut_A2521	COG0433	COG0433 Predicted ATPase
Reut_A2523	COG0151	Belongs to the GarS family
Reut_A2524	COG0408	coproporphyrinogen oxidase activity
Reut_A2525	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
Reut_A2526	COG0799	negative regulation of ribosome biogenesis
Reut_A2529	COG1530	ribonuclease E activity
Reut_A2530	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
Reut_A2544	COG0583	DNA-binding transcription factor activity
Reut_A2546	COG1522	sequence-specific DNA binding
Reut_A2547	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
Reut_A2548	COG1960	acyl-CoA dehydrogenase activity
Reut_A2552	COG2011	ABC-type metal ion transport system permease component
Reut_A2554	COG1024	Enoyl-CoA hydratase
Reut_A2556	COG2951	lytic endotransglycosylase activity
Reut_A2557	COG0859	PFAM glycosyl transferase family 9
Reut_A2558	COG1442	glycosyl transferase family 8
Reut_A2561	COG2233	PERMEase
Reut_A2564	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
Reut_A2566	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
Reut_A2573	COG0287	Prephenate dehydrogenase
Reut_A2576	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
Reut_A2584	COG1132	(ABC) transporter
Reut_A2586	COG0189	ligase activity
Reut_A2586	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
Reut_A2589	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
Reut_A2590	COG0583	DNA-binding transcription factor activity
Reut_A2591	COG1253	flavin adenine dinucleotide binding
Reut_A2592	COG0671	phosphoesterase, PA-phosphatase related
Reut_A2594	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
Reut_A2595	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
Reut_A2600	COG1674	ftsk spoiiie
Reut_A2601	COG0492	ferredoxin-NADP+ reductase activity
Reut_A2602	COG2840	Smr protein MutS2
Reut_A2603	COG2860	membrane
Reut_A2604	COG0347	Belongs to the P(II) protein family
Reut_A2608	COG2076	Multidrug Resistance protein
Reut_A2612	COG3038	cytochrome b561
Reut_A2613	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
Reut_A2617	COG2271	Major facilitator Superfamily
Reut_A2619	COG2198	Histidine kinase
Reut_A2619	COG0643	Histidine kinase
Reut_A2624	COG1773	rubredoxin
Reut_A2626	COG1704	LemA family
Reut_A2631	COG0583	DNA-binding transcription factor activity
Reut_A2635	COG0463	Glycosyl transferase, family 2
Reut_A2644	COG4964	Belongs to the GSP D family
Reut_A2657	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
Reut_A2659	COG0739	heme binding
Reut_A2659	COG1196	nuclear chromosome segregation
Reut_A2659	COG0741	lytic transglycosylase activity
Reut_A2663	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
Reut_A2666	COG5002	protein histidine kinase activity
Reut_A2666	COG3447	MASE1 domain protein
Reut_A2666	COG5001	Diguanylate cyclase
Reut_A2667	COG1301	dicarboxylic acid transport
Reut_A2671	COG2423	ornithine cyclodeaminase activity
Reut_A2673	COG1522	sequence-specific DNA binding
Reut_A2675	COG0517	IMP dehydrogenase activity
Reut_A2676	COG0628	permease
Reut_A2678	COG2995	paraquat-inducible protein a
Reut_A2679	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
Reut_A2679	COG3008	intermembrane lipid transfer
Reut_A2685	COG0795	lipopolysaccharide-transporting ATPase activity
Reut_A2688	COG3220	belongs to the UPF0276 family
Reut_A2692	COG2895	sulfate adenylyltransferase (ATP) activity
Reut_A2694	COG0175	sulfate reduction
Reut_A2697	COG0730	response to heat
Reut_A2698	COG0583	DNA-binding transcription factor activity
Reut_A2699	COG2813	Specifically methylates the guanine in position
Reut_A2701	COG2084	Dehydrogenase
Reut_A2706	COG0501	Belongs to the peptidase M48B family
Reut_A2707	COG2985	domain, Protein
Reut_A2708	COG2985	domain, Protein
Reut_A2712	COG0402	S-adenosylhomocysteine deaminase activity
Reut_A2715	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
Reut_A2716	COG2986	histidine ammonia-lyase
Reut_A2717	COG2188	Transcriptional regulator
Reut_A2719	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
Reut_A2722	COG0543	2 iron, 2 sulfur cluster binding
Reut_A2722	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
Reut_A2723	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
Reut_A2726	COG0411	ABC transporter
Reut_A2730	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
Reut_A2731	COG1047	Peptidyl-prolyl cis-trans
Reut_A2733	COG0227	Belongs to the bacterial ribosomal protein bL28 family
Reut_A2734	COG0267	Belongs to the bacterial ribosomal protein bL33 family
Reut_A2735	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
Reut_A2737	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
Reut_A2739	COG0668	transmembrane transport
Reut_A2740	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
Reut_A2740	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
Reut_A2741	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
Reut_A2742	COG2197	response regulator
Reut_A2743	COG2205	protein histidine kinase activity
Reut_A2743	COG2198	Histidine kinase
Reut_A2743	COG0784	Response regulator, receiver
Reut_A2744	COG0196	riboflavin kinase activity
Reut_A2748	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
Reut_A2749	COG0756	dUTP diphosphatase activity
Reut_A2752	COG0542	response to heat
Reut_A2754	COG1278	Cold shock
Reut_A2766	COG0728	peptidoglycan biosynthetic process
Reut_A2768	COG0586	Pfam SNARE associated Golgi protein
Reut_A2769	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
Reut_A2774	COG0628	permease
Reut_A2778	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
Reut_A2781	COG4662	Binding-protein-dependent transport system inner membrane component
Reut_A2786	COG2096	Adenosyltransferase
Reut_A2787	COG0277	FAD linked oxidase domain protein
Reut_A2788	COG0583	DNA-binding transcription factor activity
Reut_A2790	COG0277	FAD linked oxidase domain protein
Reut_A2791	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
Reut_A2792	COG0277	FAD linked oxidase domain protein
Reut_A2793	COG0247	lactate metabolic process
Reut_A2794	COG1380	Effector of murein hydrolase LrgA
Reut_A2795	COG1346	cytolysis
Reut_A2798	COG0386	Belongs to the glutathione peroxidase family
Reut_A2804	COG0783	Belongs to the Dps family
Reut_A2806	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
Reut_A2809	COG1862	Preprotein translocase
Reut_A2810	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
Reut_A2811	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
Reut_A2812	COG2204	response regulator
Reut_A2820	COG0625	glutathione transferase activity
Reut_A2823	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
Reut_A2825	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
Reut_A2826	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
Reut_A2832	COG1466	dna polymerase III delta subunit
Reut_A2833	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
Reut_A2836	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
Reut_A2837	COG0735	belongs to the Fur family
Reut_A2838	COG0583	DNA-binding transcription factor activity
Reut_A2839	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
Reut_A2840	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
Reut_A2841	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
Reut_A2843	COG1385	rRNA (uridine-N3-)-methyltransferase activity
Reut_A2847	COG0281	malic enzyme
Reut_A2847	COG0280	phosphate acetyltransferase
Reut_A2849	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
Reut_A2850	COG1058	Belongs to the CinA family
Reut_A2850	COG1546	Belongs to the CinA family
Reut_A2851	COG0284	orotidine-5'-phosphate decarboxylase activity
Reut_A2857	COG0557	exoribonuclease II activity
Reut_A2858	COG1028	Short-chain dehydrogenase reductase Sdr
Reut_A2861	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
Reut_A2864	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
Reut_A2865	COG0511	ligase activity, forming carbon-carbon bonds
Reut_A2866	COG0439	Biotin carboxylase
Reut_A2869	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
Reut_A2875	COG3181	Tripartite tricarboxylate transporter family receptor
Reut_A2876	COG4774	siderophore transport
Reut_A2881	COG0656	L-ascorbic acid biosynthetic process
Reut_A2884	COG2814	Major facilitator Superfamily
Reut_A2888	COG2304	oxidoreductase activity
Reut_A2891	COG0714	Associated with various cellular activities
Reut_A2893	COG3119	arylsulfatase activity
Reut_A2895	COG1262	PFAM Formylglycine-generating sulfatase enzyme
Reut_A2900	COG0628	permease
Reut_A2902	COG0789	Transcriptional regulator
Reut_A2906	COG0025	NhaP-type Na H and K H
Reut_A2910	COG0583	DNA-binding transcription factor activity
Reut_A2923	COG3210	domain, Protein
Reut_A2928	COG3210	domain, Protein
Reut_A2933	COG4223	transferase activity, transferring acyl groups other than amino-acyl groups
Reut_A2933	COG3210	domain, Protein
Reut_A2933	COG3064	Membrane
Reut_A2947	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
Reut_A2951	COG0741	lytic transglycosylase activity
Reut_A2959	COG0142	geranyltranstransferase activity
Reut_A2965	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
Reut_A2966	COG1297	OPT oligopeptide transporter protein
Reut_A2967	COG0494	nUDIX hydrolase
Reut_A2973	COG0678	peroxiredoxin activity
Reut_A2976	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
Reut_A2983	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
Reut_A2984	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
Reut_A2986	COG3116	cell division
Reut_A2990	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
Reut_A2994	COG0318	PFAM AMP-dependent synthetase and ligase
Reut_A2996	COG0318	PFAM AMP-dependent synthetase and ligase
Reut_A2997	COG4770	biotin carboxylase activity
Reut_A3000	COG0243	molybdopterin cofactor binding
Reut_A3002	COG4608	Belongs to the ABC transporter superfamily
Reut_A3004	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
Reut_A3005	COG0601	transmembrane transport
Reut_A3006	COG0747	negative chemotaxis
Reut_A3007	COG1473	amidohydrolase
Reut_A3010	COG1024	Enoyl-CoA hydratase
Reut_A3011	COG0859	PFAM glycosyl transferase family 9
Reut_A3012	COG1126	abc transporter atp-binding protein
Reut_A3013	COG0765	amino acid transport
Reut_A3015	COG1024	Enoyl-CoA hydratase
Reut_A3016	COG2050	protein possibly involved in aromatic compounds catabolism
Reut_A3020	COG2967	ApaG domain
Reut_A3022	COG0546	phosphoglycolate phosphatase activity
Reut_A3028	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
Reut_A3030	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
Reut_A3031	COG1116	anion transmembrane transporter activity
Reut_A3032	COG1289	transmembrane transporter activity
Reut_A3034	COG0604	alcohol dehydrogenase
Reut_A3035	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
Reut_A3036	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
Reut_A3037	COG0012	GTP binding
Reut_A3041	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
Reut_A3046	COG2890	protein-(glutamine-N5) methyltransferase activity
Reut_A3047	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
Reut_A3048	COG0163	prenyltransferase activity
Reut_A3050	COG1012	belongs to the aldehyde dehydrogenase family
Reut_A3052	COG1522	sequence-specific DNA binding
Reut_A3055	COG0038	chloride channel
Reut_A3058	COG0583	DNA-binding transcription factor activity
Reut_A3063	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Reut_A3065	COG1408	metallophosphoesterase
Reut_A3066	COG0488	(ABC) transporter
Reut_A3068	COG1451	nucleotide metabolic process
Reut_A3071	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
Reut_A3072	COG2233	PERMEase
Reut_A3073	COG0583	DNA-binding transcription factor activity
Reut_A3074	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
Reut_A3076	COG1529	Aldehyde oxidase and xanthine dehydrogenase
Reut_A3078	COG0523	cobalamin synthesis protein
Reut_A3079	COG3708	Transcriptional regulator
Reut_A3079	COG2207	Transcriptional regulator
Reut_A3080	COG2233	PERMEase
Reut_A3088	COG1024	Enoyl-CoA hydratase
Reut_A3089	COG2969	positive regulation of protein catabolic process
Reut_A3090	COG0625	glutathione transferase activity
Reut_A3091	COG2857	Cytochrome c1
Reut_A3092	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
Reut_A3093	COG0723	plastoquinol--plastocyanin reductase activity
Reut_A3095	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
Reut_A3096	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Reut_A3097	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
Reut_A3098	COG0805	protein transport
Reut_A3108	COG2095	MarC family integral membrane protein
Reut_A3115	COG0842	Transport permease protein
Reut_A3116	COG1131	(ABC) transporter
Reut_A3120	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
Reut_A3121	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
Reut_A3122	COG1127	ABC transporter
Reut_A3126	COG0070	glutamate synthase
Reut_A3126	COG0067	glutamate synthase
Reut_A3126	COG0069	glutamate synthase activity
Reut_A3128	COG0232	Belongs to the dGTPase family. Type 2 subfamily
Reut_A3139	COG0019	diaminopimelate decarboxylase activity
Reut_A3140	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
Reut_A3141	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
Reut_A3145	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
Reut_A3146	COG1333	cytochrome c biogenesis protein
Reut_A3147	COG2863	cytochrome
Reut_A3150	COG0598	Magnesium transport protein CorA
Reut_A3151	COG4232	protein-disulfide reductase activity
Reut_A3156	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
Reut_A3158	COG0257	Belongs to the bacterial ribosomal protein bL36 family
Reut_A3159	COG0201	protein transport
Reut_A3161	COG1841	ribosomal large subunit assembly
Reut_A3163	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
Reut_A3165	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
Reut_A3169	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
Reut_A3171	COG0255	Belongs to the universal ribosomal protein uL29 family
Reut_A3172	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
Reut_A3174	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
Reut_A3177	COG0089	rRNA binding
Reut_A3181	COG0051	transcription antitermination factor activity, RNA binding
Reut_A3184	COG0049	tRNA binding
Reut_A3186	COG0514	ATP-dependent DNA helicase (RecQ)
Reut_A3198	COG0700	Nucleoside recognition
Reut_A3201	COG0589	response to stress
Reut_A3206	COG3396	Phenylacetate-CoA oxygenase
Reut_A3207	COG3460	Phenylacetate-CoA oxygenase
Reut_A3208	COG3396	Phenylacetate-CoA oxygenase
Reut_A3209	COG2151	metal-sulfur cluster biosynthetic enzyme
Reut_A3210	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
Reut_A3219	COG1017	nitric oxide dioxygenase activity
Reut_A3219	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
Reut_A3220	COG1959	2 iron, 2 sulfur cluster binding
Reut_A3226	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
Reut_A3238	COG0738	Major facilitator superfamily
Reut_A3239	COG3384	dioxygenase
Reut_A3242	COG2818	Glycosylase
Reut_A3243	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
Reut_A3245	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
Reut_A3247	COG2814	Major facilitator Superfamily
Reut_A3249	COG0737	Belongs to the 5'-nucleotidase family
Reut_A3250	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
Reut_A3256	COG4654	Cytochrome c, class I
Reut_A3257	COG4654	Cytochrome c, class I
Reut_A3258	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
Reut_A3259	COG0640	Transcriptional regulator
Reut_A3261	COG0446	pyridine nucleotide-disulphide oxidoreductase
Reut_A3262	COG2863	cytochrome
Reut_A3263	COG2823	Periplasmic or secreted lipoprotein
Reut_A3264	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
Reut_A3268	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Reut_A3271	COG1393	Belongs to the ArsC family
Reut_A3275	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
Reut_A3279	COG1301	dicarboxylic acid transport
Reut_A3282	COG1024	Enoyl-CoA hydratase
Reut_A3283	COG0318	PFAM AMP-dependent synthetase and ligase
Reut_A3286	COG0583	DNA-binding transcription factor activity
Reut_A3289	COG1473	amidohydrolase
Reut_A3291	COG3960	tartronate-semialdehyde synthase activity
Reut_A3292	COG3622	Belongs to the hyi family
Reut_A3293	COG2084	Dehydrogenase
Reut_A3295	COG0469	pyruvate kinase activity
Reut_A3296	COG2321	neutral zinc metallopeptidase
Reut_A3298	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
Reut_A3299	COG0789	Transcriptional regulator
Reut_A3300	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
Reut_A3304	COG4262	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
Reut_A3307	COG0501	Belongs to the peptidase M48B family
Reut_A3318	COG0277	FAD linked oxidase domain protein
Reut_A3319	COG3713	MltA-interacting MipA family protein
Reut_A3322	COG3245	cytochrome
Reut_A3323	COG0635	Involved in the biosynthesis of porphyrin-containing compound
Reut_A3326	COG0745	RESPONSE REGULATOR receiver
Reut_A3327	COG0210	DNA helicase
Reut_A3330	COG0509	glycine decarboxylation via glycine cleavage system
Reut_A3332	COG2323	membrane
Reut_A3333	COG1760	l-serine dehydratase
Reut_A3334	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Reut_A3339	COG0683	leucine binding
Reut_A3341	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
Reut_A3344	COG1832	CoA-binding protein
Reut_A3352	COG0356	it plays a direct role in the translocation of protons across the membrane
Reut_A3355	COG1192	Involved in chromosome partitioning
Reut_A3359	COG3181	Tripartite tricarboxylate transporter family receptor
Reut_A3362	COG0411	ABC transporter
Reut_A3367	COG4177	L-phenylalanine transmembrane transporter activity
Reut_A3373	COG0583	DNA-binding transcription factor activity
Reut_A3374	COG2267	carboxylic ester hydrolase activity
Reut_A3375	COG0789	Transcriptional regulator
Reut_A3376	COG2217	Heavy metal translocating P-type atpase
Reut_A3378	COG3047	cAMP biosynthetic process
Reut_A3379	COG2015	COG2015, Alkyl sulfatase and related hydrolases
Reut_A3381	COG2423	ornithine cyclodeaminase activity
Reut_A3382	COG0667	Aldo Keto reductase
Reut_A3383	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
Reut_A3386	COG1522	sequence-specific DNA binding
Reut_A3387	COG3186	Phenylalanine-4-hydroxylase
Reut_A3390	COG0642	Histidine kinase
Reut_A3394	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
Reut_A3396	COG4663	Part of the tripartite ATP-independent periplasmic (TRAP) transport system
Reut_A3398	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
Reut_A3402	COG2204	response regulator
Reut_A3403	COG5000	phosphorelay sensor kinase activity
Reut_A3405	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
Reut_A3406	COG0501	Belongs to the peptidase M48B family
Reut_A3407	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
Reut_A3408	COG0242	peptide deformylase activity
Reut_A3410	COG0758	DNA mediated transformation
Reut_A3413	COG0583	DNA-binding transcription factor activity
Reut_A3416	COG2879	small protein
Reut_A3417	COG1966	Carbon starvation protein
Reut_A3420	COG1274	phosphoenolpyruvate carboxykinase (GTP) activity
Reut_A3421	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
Reut_A3422	COG2814	Major facilitator Superfamily
Reut_A3423	COG2258	MOSC domain
Reut_A3439	COG1309	transcriptional regulator
Reut_A3440	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Reut_A3441	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
Reut_A3442	COG1538	Outer membrane efflux protein
Reut_A3447	COG0583	DNA-binding transcription factor activity
Reut_A3452	COG1819	glycosyl
Reut_A3454	COG4691	Plasmid stability protein
Reut_A3455	COG1487	ribonuclease activity
Reut_A3459	COG4106	trans-aconitate 2-methyltransferase activity
Reut_A3462	COG0594	ribonuclease P activity
Reut_A3463	COG0230	Belongs to the bacterial ribosomal protein bL34 family
Reut_B3467	COG1233	COG1233 Phytoene dehydrogenase and related
Reut_B3468	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
Reut_B3470	COG1028	Short-chain dehydrogenase reductase Sdr
Reut_B3478	COG0384	phenazine biosynthesis protein PhzF
Reut_B3482	COG3264	Mechanosensitive ion channel
Reut_B3482	COG1511	domain protein
Reut_B3486	COG1028	Short-chain dehydrogenase reductase Sdr
Reut_B3487	COG0583	DNA-binding transcription factor activity
Reut_B3493	COG0625	glutathione transferase activity
Reut_B3495	COG2226	methyltransferase
Reut_B3506	COG2205	protein histidine kinase activity
Reut_B3506	COG0784	Response regulator, receiver
Reut_B3509	COG2188	Transcriptional regulator
Reut_B3510	COG0028	Belongs to the TPP enzyme family
Reut_B3521	COG1215	transferase activity, transferring glycosyl groups
Reut_B3525	COG0457	Tetratricopeptide repeat
Reut_B3526	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
Reut_B3527	COG1215	transferase activity, transferring glycosyl groups
Reut_B3529	COG2721	sulfolactate sulfo-lyase activity
Reut_B3530	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
Reut_B3531	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
Reut_B3533	COG2188	Transcriptional regulator
Reut_B3534	COG1960	acyl-CoA dehydrogenase activity
Reut_B3535	COG1960	acyl-CoA dehydrogenase activity
Reut_B3536	COG0318	PFAM AMP-dependent synthetase and ligase
Reut_B3538	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
Reut_B3539	COG2301	Belongs to the HpcH HpaI aldolase family
Reut_B3542	COG1960	acyl-CoA dehydrogenase activity
Reut_B3544	COG0583	DNA-binding transcription factor activity
Reut_B3545	COG1028	Short-chain dehydrogenase reductase Sdr
Reut_B3546	COG1804	L-carnitine dehydratase bile acid-inducible protein F
Reut_B3549	COG0318	PFAM AMP-dependent synthetase and ligase
Reut_B3551	COG1024	Enoyl-CoA hydratase
Reut_B3553	COG2766	serine protein kinase
Reut_B3554	COG2718	Belongs to the UPF0229 family
Reut_B3555	COG2719	SpoVR family
Reut_B3557	COG1960	acyl-CoA dehydrogenase activity
Reut_B3559	COG2030	dehydratase
Reut_B3560	COG1804	L-carnitine dehydratase bile acid-inducible protein F
Reut_B3561	COG0583	DNA-binding transcription factor activity
Reut_B3563	COG0668	transmembrane transport
Reut_B3567	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
Reut_B3571	COG1028	Short-chain dehydrogenase reductase Sdr
Reut_B3573	COG1414	Transcriptional regulator
Reut_B3574	COG1028	Short-chain dehydrogenase reductase Sdr
Reut_B3575	COG0028	Belongs to the TPP enzyme family
Reut_B3576	COG1712	Catalyzes the reversible NADPH-dependent reductive amination of L-2-amino-6-oxopimelate, the acyclic form of L- tetrahydrodipicolinate, to generate the meso compound, D,L-2,6- diaminopimelate
Reut_B3577	COG1012	belongs to the aldehyde dehydrogenase family
Reut_B3580	COG2271	Major facilitator Superfamily
Reut_B3581	COG0626	cystathionine gamma-synthase activity
Reut_B3583	COG1126	abc transporter atp-binding protein
Reut_B3587	COG4977	sequence-specific DNA binding
Reut_B3591	COG0730	response to heat
Reut_B3593	COG3181	Tripartite tricarboxylate transporter family receptor
Reut_B3598	COG1414	Transcriptional regulator
Reut_B3601	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
Reut_B3602	COG4566	intracellular signal transduction
Reut_B3603	COG1960	acyl-CoA dehydrogenase activity
Reut_B3604	COG1960	acyl-CoA dehydrogenase activity
Reut_B3606	COG2197	response regulator
Reut_B3607	COG0778	Nitroreductase
Reut_B3608	COG1024	Enoyl-CoA hydratase
Reut_B3611	COG0183	Belongs to the thiolase family
Reut_B3614	COG3181	Tripartite tricarboxylate transporter family receptor
Reut_B3616	COG0322	excinuclease ABC activity
Reut_B3617	COG0477	Major facilitator Superfamily
Reut_B3619	COG2197	response regulator
Reut_B3621	COG2963	transposase activity
Reut_B3623	COG3064	Membrane
Reut_B3625	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
Reut_B3629	COG1773	rubredoxin
Reut_B3632	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
Reut_B3633	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
Reut_B3635	COG1845	cytochrome c oxidase, subunit III
Reut_B3642	COG0534	Mate efflux family protein
Reut_B3647	COG5001	Diguanylate cyclase
Reut_B3647	COG4251	negative regulation of phosphorylation
Reut_B3647	COG3706	GGDEF domain
Reut_B3647	COG2203	Gaf domain
Reut_B3653	COG0840	transmembrane signaling receptor activity
Reut_B3654	COG3300	MHYT domain
Reut_B3654	COG5001	Diguanylate cyclase
Reut_B3658	COG0411	ABC transporter
Reut_B3660	COG0559	Belongs to the binding-protein-dependent transport system permease family
Reut_B3663	COG1028	Short-chain dehydrogenase reductase Sdr
Reut_B3665	COG2814	Major facilitator Superfamily
Reut_B3666	COG0784	Response regulator, receiver
Reut_B3666	COG2205	protein histidine kinase activity
Reut_B3667	COG2197	response regulator
Reut_B3678	COG1012	belongs to the aldehyde dehydrogenase family
Reut_B3681	COG2814	Major facilitator Superfamily
Reut_B3682	COG4264	IucA IucC family
Reut_B3683	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
Reut_B3684	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
Reut_B3685	COG0019	diaminopimelate decarboxylase activity
Reut_B3689	COG2271	Major facilitator Superfamily
Reut_B3690	COG2721	sulfolactate sulfo-lyase activity
Reut_B3691	COG1028	Short-chain dehydrogenase reductase Sdr
Reut_B3692	COG0583	DNA-binding transcription factor activity
Reut_B3693	COG0583	DNA-binding transcription factor activity
Reut_B3694	COG1279	arginine transmembrane transporter activity
Reut_B3697	COG1126	abc transporter atp-binding protein
Reut_B3698	COG0765	amino acid transport
Reut_B3699	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Reut_B3702	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
Reut_B3707	COG1804	L-carnitine dehydratase bile acid-inducible protein F
Reut_B3708	COG1024	Enoyl-CoA hydratase
Reut_B3709	COG1960	acyl-CoA dehydrogenase activity
Reut_B3710	COG1960	acyl-CoA dehydrogenase activity
Reut_B3714	COG2186	Transcriptional regulator
Reut_B3721	COG1012	belongs to the aldehyde dehydrogenase family
Reut_B3723	COG3539	Fimbrial protein
Reut_B3724	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
Reut_B3725	COG0840	transmembrane signaling receptor activity
Reut_B3728	COG2610	gluconate transmembrane transporter activity
Reut_B3729	COG1028	Short-chain dehydrogenase reductase Sdr
Reut_B3733	COG1881	PFAM PEBP family protein
Reut_B3734	COG3327	negative regulation of DNA-templated transcription, initiation
Reut_B3735	COG3396	Phenylacetate-CoA oxygenase
Reut_B3736	COG3460	Phenylacetate-CoA oxygenase
Reut_B3737	COG3396	Phenylacetate-CoA oxygenase
Reut_B3738	COG2151	metal-sulfur cluster biosynthetic enzyme
Reut_B3739	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
Reut_B3742	COG3162	membrane
Reut_B3749	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
Reut_B3750	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
Reut_B3752	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
Reut_B3753	COG1113	amino acid transport
Reut_B3754	COG1414	Transcriptional regulator
Reut_B3760	COG3069	C4-dicarboxylate transmembrane transporter activity
Reut_B3765	COG0543	2 iron, 2 sulfur cluster binding
Reut_B3765	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
Reut_B3766	COG1802	Transcriptional regulator
Reut_B3771	COG0730	response to heat
Reut_B3772	COG0280	phosphate acetyltransferase
Reut_B3779	COG4214	carbohydrate transport
Reut_B3782	COG1137	ATPase activity
Reut_B3784	COG0477	Major facilitator Superfamily
Reut_B3786	COG3473	Maleate cis-trans isomerase
Reut_B3787	COG0596	Alpha beta hydrolase
Reut_B3788	COG2309	aminopeptidase activity
Reut_B3789	COG1335	isochorismatase
Reut_B3797	COG3181	Tripartite tricarboxylate transporter family receptor
Reut_B3805	COG2814	Major facilitator Superfamily
Reut_B3809	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
Reut_B3818	COG0251	oxidation-reduction process
Reut_B3819	COG3181	Tripartite tricarboxylate transporter family receptor
Reut_B3820	COG0165	Argininosuccinate lyase
Reut_B3824	COG1804	L-carnitine dehydratase bile acid-inducible protein F
Reut_B3825	COG1960	acyl-CoA dehydrogenase activity
Reut_B3826	COG2015	COG2015, Alkyl sulfatase and related hydrolases
Reut_B3827	COG1042	CoA-binding domain protein
Reut_B3827	COG0045	succinate-CoA ligase (ADP-forming) activity
Reut_B3827	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
Reut_B3832	COG2197	response regulator
Reut_B3834	COG1028	Short-chain dehydrogenase reductase Sdr
Reut_B3835	COG1960	acyl-CoA dehydrogenase activity
Reut_B3836	COG1960	acyl-CoA dehydrogenase activity
Reut_B3838	COG1028	Short-chain dehydrogenase reductase Sdr
Reut_B3842	COG3246	L-lysine catabolic process to acetate
Reut_B3844	COG2197	response regulator
Reut_B3847	COG2175	clavaminate synthase activity
Reut_B3852	COG2130	NADP-dependent
Reut_B3855	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
Reut_B3856	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Reut_B3857	COG1960	acyl-CoA dehydrogenase activity
Reut_B3859	COG3181	Tripartite tricarboxylate transporter family receptor
Reut_B3860	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
Reut_B3865	COG1028	Short-chain dehydrogenase reductase Sdr
Reut_B3868	COG0045	succinate-CoA ligase (ADP-forming) activity
Reut_B3870	COG1960	acyl-CoA dehydrogenase activity
Reut_B3873	COG1024	Enoyl-CoA hydratase
Reut_B3873	COG1250	3-hydroxyacyl-CoA dehydrogenase
Reut_B3874	COG1804	L-carnitine dehydratase bile acid-inducible protein F
Reut_B3876	COG1804	L-carnitine dehydratase bile acid-inducible protein F
Reut_B3877	COG0604	alcohol dehydrogenase
Reut_B3879	COG1804	L-carnitine dehydratase bile acid-inducible protein F
Reut_B3883	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
Reut_B3883	COG0045	succinate-CoA ligase (ADP-forming) activity
Reut_B3883	COG1042	CoA-binding domain protein
Reut_B3891	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
Reut_B3892	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
Reut_B3895	COG1793	dna ligase
Reut_B3896	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
Reut_B3896	COG1793	dna ligase
Reut_B3900	COG0471	metal ion transport
Reut_B3902	COG3246	L-lysine catabolic process to acetate
Reut_B3908	COG0785	Cytochrome C biogenesis protein
Reut_B3908	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
Reut_B3909	COG0745	RESPONSE REGULATOR receiver
Reut_B3914	COG1846	Transcriptional regulator
Reut_B3915	COG1028	Short-chain dehydrogenase reductase Sdr
Reut_B3916	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
Reut_B3918	COG0318	PFAM AMP-dependent synthetase and ligase
Reut_B3927	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
Reut_B3928	COG0726	polysaccharide deacetylase
Reut_B3932	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
Reut_B3935	COG1028	Short-chain dehydrogenase reductase Sdr
Reut_B3938	COG2814	Major facilitator Superfamily
Reut_B3939	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
Reut_B3941	COG3108	Peptidase M15
Reut_B3942	COG2989	Protein conserved in bacteria
Reut_B3944	COG2084	Dehydrogenase
Reut_B3947	COG3550	peptidyl-serine autophosphorylation
Reut_B3949	COG3181	Tripartite tricarboxylate transporter family receptor
Reut_B3950	COG0129	dihydroxy-acid dehydratase activity
Reut_B3955	COG0583	DNA-binding transcription factor activity
Reut_B3956	COG1250	3-hydroxyacyl-CoA dehydrogenase
Reut_B3957	COG3246	L-lysine catabolic process to acetate
Reut_B3973	COG0726	polysaccharide deacetylase
Reut_B3974	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
Reut_B3974	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Reut_B3978	COG2076	Multidrug Resistance protein
Reut_B3979	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
Reut_B3987	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
Reut_B3988	COG1309	transcriptional regulator
Reut_B3993	COG0402	S-adenosylhomocysteine deaminase activity
Reut_B3994	COG3706	GGDEF domain
Reut_B3999	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
Reut_B4001	COG0840	transmembrane signaling receptor activity
Reut_B4003	COG0667	Aldo Keto reductase
Reut_B4004	COG0531	amino acid
Reut_B4008	COG4177	L-phenylalanine transmembrane transporter activity
Reut_B4009	COG0411	ABC transporter
Reut_B4011	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
Reut_B4012	COG2267	carboxylic ester hydrolase activity
Reut_B4013	COG2453	phosphatase
Reut_B4013	COG0671	phosphoesterase, PA-phosphatase related
Reut_B4016	COG4589	Belongs to the CDS family
Reut_B4017	COG0683	leucine binding
Reut_B4020	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
Reut_B4023	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
Reut_B4024	COG0800	Aldolase
Reut_B4026	COG1253	flavin adenine dinucleotide binding
Reut_B4033	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
Reut_B4036	COG2814	Major facilitator Superfamily
Reut_B4037	COG0668	transmembrane transport
Reut_B4038	COG0004	ammonium transporteR
Reut_B4040	COG1607	acyl-coa hydrolase
Reut_B4041	COG3045	CreA protein
Reut_B4042	COG0318	PFAM AMP-dependent synthetase and ligase
Reut_B4043	COG1028	Short-chain dehydrogenase reductase Sdr
Reut_B4047	COG2205	protein histidine kinase activity
Reut_B4049	COG0745	RESPONSE REGULATOR receiver
Reut_B4053	COG1285	pathogenesis
Reut_B4057	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
Reut_B4062	COG0784	Response regulator, receiver
Reut_B4062	COG3437	response regulator, receiver
Reut_B4064	COG1902	pentaerythritol trinitrate reductase activity
Reut_B4066	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
Reut_B4068	COG3437	response regulator, receiver
Reut_B4069	COG5002	protein histidine kinase activity
Reut_B4069	COG0784	Response regulator, receiver
Reut_B4069	COG2205	protein histidine kinase activity
Reut_B4073	COG0154	amidase activity
Reut_B4078	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
Reut_B4080	COG3391	amine dehydrogenase activity
Reut_B4082	COG1566	PFAM secretion protein HlyD family protein
Reut_B4084	COG0583	DNA-binding transcription factor activity
Reut_B4088	COG1538	Outer membrane efflux protein
Reut_B4091	COG0243	molybdopterin cofactor binding
Reut_B4092	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
Reut_B4093	COG0303	'Molybdopterin
Reut_B4094	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
Reut_B4096	COG1566	PFAM secretion protein HlyD family protein
Reut_B4100	COG1294	oxidase, subunit
Reut_B4101	COG1271	oxidase subunit
Reut_B4112	COG2198	Histidine kinase
Reut_B4112	COG0784	Response regulator, receiver
Reut_B4112	COG2205	protein histidine kinase activity
Reut_B4112	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Reut_B4115	COG0473	3-isopropylmalate dehydrogenase activity
Reut_B4116	COG0583	DNA-binding transcription factor activity
Reut_B4121	COG2271	Major facilitator Superfamily
Reut_B4122	COG4948	Mandelate Racemase Muconate Lactonizing
Reut_B4127	COG1028	Short-chain dehydrogenase reductase Sdr
Reut_B4132	COG0402	S-adenosylhomocysteine deaminase activity
Reut_B4133	COG1129	ABC transporter
Reut_B4134	COG1172	Belongs to the binding-protein-dependent transport system permease family
Reut_B4135	COG1172	Belongs to the binding-protein-dependent transport system permease family
Reut_B4136	COG1879	ABC-type sugar transport system periplasmic component
Reut_B4137	COG3485	protocatechuate 3,4-dioxygenase
Reut_B4140	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
Reut_B4141	COG0569	domain protein
Reut_B4141	COG2985	domain, Protein
Reut_B4142	COG3181	Tripartite tricarboxylate transporter family receptor
Reut_B4143	COG0154	amidase activity
Reut_B4144	COG0583	DNA-binding transcription factor activity
Reut_B4146	COG0583	DNA-binding transcription factor activity
Reut_B4149	COG2030	dehydratase
Reut_B4151	COG1804	L-carnitine dehydratase bile acid-inducible protein F
Reut_B4154	COG1960	acyl-CoA dehydrogenase activity
Reut_B4155	COG0318	PFAM AMP-dependent synthetase and ligase
Reut_B4156	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
Reut_B4158	COG2175	clavaminate synthase activity
Reut_B4162	COG1804	L-carnitine dehydratase bile acid-inducible protein F
Reut_B4163	COG3181	Tripartite tricarboxylate transporter family receptor
Reut_B4164	COG2909	trisaccharide binding
Reut_B4165	COG0318	PFAM AMP-dependent synthetase and ligase
Reut_B4166	COG1960	acyl-CoA dehydrogenase activity
Reut_B4167	COG0183	Belongs to the thiolase family
Reut_B4170	COG1028	Short-chain dehydrogenase reductase Sdr
Reut_B4171	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
Reut_B4178	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
Reut_B4179	COG3639	organic phosphonate transmembrane transporter activity
Reut_B4182	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
Reut_B4183	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
Reut_B4184	COG3454	Phosphonate metabolism
Reut_B4185	COG2188	Transcriptional regulator
Reut_B4186	COG3624	Phosphonate C-P lyase system protein PhnG
Reut_B4187	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
Reut_B4188	COG3626	phosphonate metabolism
Reut_B4189	COG3627	carbon phosphorus lyase activity
Reut_B4190	COG4107	phosphonate C-P lyase system protein PhnK
Reut_B4191	COG4778	phosphonate C-P lyase system protein PhnL
Reut_B4192	COG3454	Phosphonate metabolism
Reut_B4194	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Reut_B4196	COG3845	ABC transporter
Reut_B4198	COG2188	Transcriptional regulator
Reut_B4212	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
Reut_B4227	COG0366	Alpha amylase catalytic
Reut_B4232	COG0058	SHG alpha-glucan phosphorylase activity
Reut_B4233	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
Reut_B4236	COG2823	Periplasmic or secreted lipoprotein
Reut_B4240	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
Reut_B4241	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
Reut_B4241	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
Reut_B4244	COG0583	DNA-binding transcription factor activity
Reut_B4245	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
Reut_B4246	COG4771	TonB-dependent receptor
Reut_B4255	COG0745	RESPONSE REGULATOR receiver
Reut_B4255	COG3706	GGDEF domain
Reut_B4257	COG1960	acyl-CoA dehydrogenase activity
Reut_B4260	COG1024	Enoyl-CoA hydratase
Reut_B4261	COG1024	Enoyl-CoA hydratase
Reut_B4263	COG3321	synthase
Reut_B4263	COG1028	Short-chain dehydrogenase reductase Sdr
Reut_B4263	COG0604	alcohol dehydrogenase
Reut_B4268	COG0436	Aminotransferase
Reut_B4272	COG2375	cellular response to nickel ion
Reut_B4274	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Reut_B4275	COG0277	FAD linked oxidase domain protein
Reut_B4277	COG1012	belongs to the aldehyde dehydrogenase family
Reut_B4278	COG2721	sulfolactate sulfo-lyase activity
Reut_B4281	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
Reut_B4284	COG1271	oxidase subunit
Reut_B4285	COG1294	oxidase, subunit
Reut_B4288	COG0583	DNA-binding transcription factor activity
Reut_B4291	COG1309	transcriptional regulator
Reut_B4297	COG0400	carboxylic ester hydrolase activity
Reut_B4300	COG1473	amidohydrolase
Reut_B4303	COG0583	DNA-binding transcription factor activity
Reut_B4308	COG0318	PFAM AMP-dependent synthetase and ligase
Reut_B4313	COG2271	Major facilitator Superfamily
Reut_B4317	COG1902	pentaerythritol trinitrate reductase activity
Reut_B4320	COG2814	Major facilitator Superfamily
Reut_B4325	COG1183	phosphatidylcholine synthase activity
Reut_B4335	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Reut_B4338	COG2032	superoxide dismutase activity
Reut_B4343	COG5001	Diguanylate cyclase
Reut_B4343	COG3300	MHYT domain
Reut_B4346	COG0484	heat shock protein binding
Reut_B4353	COG1289	transmembrane transporter activity
Reut_B4356	COG3181	Tripartite tricarboxylate transporter family receptor
Reut_B4366	COG0583	DNA-binding transcription factor activity
Reut_B4368	COG2205	protein histidine kinase activity
Reut_B4371	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
Reut_B4376	COG1028	Short-chain dehydrogenase reductase Sdr
Reut_B4385	COG2192	nodulation
Reut_B4386	COG0859	PFAM glycosyl transferase family 9
Reut_B4387	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
Reut_B4388	COG1028	Short-chain dehydrogenase reductase Sdr
Reut_B4390	COG0438	transferase activity, transferring glycosyl groups
Reut_B4394	COG5265	(ABC) transporter
Reut_B4395	COG0517	IMP dehydrogenase activity
Reut_B4396	COG1573	uracil-dna glycosylase
Reut_B4399	COG0387	Pfam Sodium calcium exchanger
Reut_B4400	COG4948	Mandelate Racemase Muconate Lactonizing
Reut_B4401	COG0583	DNA-binding transcription factor activity
Reut_B4403	COG4638	Rieske (2fe-2S)
Reut_B4404	COG5517	Aromatic-ring-hydroxylating dioxygenase beta subunit
Reut_B4405	COG0543	2 iron, 2 sulfur cluster binding
Reut_B4405	COG0633	Ferredoxin
Reut_B4406	COG1028	Short-chain dehydrogenase reductase Sdr
Reut_B4408	COG1295	ribonuclease BN
Reut_B4409	COG3546	catalase activity
Reut_B4412	COG0583	DNA-binding transcription factor activity
Reut_B4413	COG3181	Tripartite tricarboxylate transporter family receptor
Reut_B4420	COG1804	L-carnitine dehydratase bile acid-inducible protein F
Reut_B4423	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
Reut_B4428	COG0437	4 iron, 4 sulfur cluster binding
Reut_B4436	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
Reut_B4440	COG0028	Belongs to the TPP enzyme family
Reut_B4441	COG4948	Mandelate Racemase Muconate Lactonizing
Reut_B4442	COG0247	lactate metabolic process
Reut_B4442	COG0277	FAD linked oxidase domain protein
Reut_B4446	COG1309	transcriptional regulator
Reut_B4447	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
Reut_B4447	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
Reut_B4448	COG2814	Major facilitator Superfamily
Reut_B4452	COG0678	peroxiredoxin activity
Reut_B4452	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
Reut_B4453	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
Reut_B4454	COG0492	ferredoxin-NADP+ reductase activity
Reut_B4456	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
Reut_B4461	COG1024	Enoyl-CoA hydratase
Reut_B4462	COG1960	acyl-CoA dehydrogenase activity
Reut_B4463	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
Reut_B4466	COG1858	cytochrome C peroxidase
Reut_B4471	COG2205	protein histidine kinase activity
Reut_B4471	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Reut_B4472	COG2205	protein histidine kinase activity
Reut_B4472	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Reut_B4478	COG0714	Associated with various cellular activities
Reut_B4479	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Reut_B4480	COG2304	oxidoreductase activity
Reut_B4481	COG0567	Dehydrogenase, E1 component
Reut_B4490	COG0028	Belongs to the TPP enzyme family
Reut_B4491	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
Reut_B4494	COG0583	DNA-binding transcription factor activity
Reut_B4497	COG3181	Tripartite tricarboxylate transporter family receptor
Reut_B4503	COG1448	Aminotransferase
Reut_B4504	COG1028	Short-chain dehydrogenase reductase Sdr
Reut_B4505	COG2080	2 iron, 2 sulfur cluster binding
Reut_B4506	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
Reut_B4507	COG1529	Aldehyde oxidase and xanthine dehydrogenase
Reut_B4512	COG3588	fructose-bisphosphate aldolase
Reut_B4518	COG1804	L-carnitine dehydratase bile acid-inducible protein F
Reut_B4520	COG3181	Tripartite tricarboxylate transporter family receptor
Reut_B4522	COG1573	uracil-dna glycosylase
Reut_B4523	COG0587	DNA-directed DNA polymerase activity
Reut_B4526	COG1024	Enoyl-CoA hydratase
Reut_B4528	COG1609	Transcriptional regulator
Reut_B4530	COG0402	S-adenosylhomocysteine deaminase activity
Reut_B4531	COG2233	PERMEase
Reut_B4533	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
Reut_B4536	COG2271	Major facilitator Superfamily
Reut_B4537	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
Reut_B4540	COG2855	membrane
Reut_B4541	COG1309	transcriptional regulator
Reut_B4542	COG2175	clavaminate synthase activity
Reut_B4545	COG0154	amidase activity
Reut_B4547	COG0514	ATP-dependent DNA helicase (RecQ)
Reut_B4549	COG1024	Enoyl-CoA hydratase
Reut_B4550	COG3181	Tripartite tricarboxylate transporter family receptor
Reut_B4551	COG3181	Tripartite tricarboxylate transporter family receptor
Reut_B4552	COG1804	L-carnitine dehydratase bile acid-inducible protein F
Reut_B4557	COG1028	Short-chain dehydrogenase reductase Sdr
Reut_B4558	COG1960	acyl-CoA dehydrogenase activity
Reut_B4559	COG1960	acyl-CoA dehydrogenase activity
Reut_B4560	COG1024	Enoyl-CoA hydratase
Reut_B4561	COG0183	Belongs to the thiolase family
Reut_B4563	COG1960	acyl-CoA dehydrogenase activity
Reut_B4568	COG1262	PFAM Formylglycine-generating sulfatase enzyme
Reut_B4569	COG3119	arylsulfatase activity
Reut_B4575	COG2814	Major facilitator Superfamily
Reut_B4578	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
Reut_B4579	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
Reut_B4580	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
Reut_B4582	COG2733	membrane
Reut_B4584	COG0417	DNA replication proofreading
Reut_B4586	COG3064	Membrane
Reut_B4589	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
Reut_B4595	COG1414	Transcriptional regulator
Reut_B4597	COG1024	Enoyl-CoA hydratase
Reut_B4602	COG0745	RESPONSE REGULATOR receiver
Reut_B4603	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
Reut_B4605	COG0123	including yeast histone deacetylase and acetoin utilization protein
Reut_B4608	COG0392	lysyltransferase activity
Reut_B4609	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
Reut_B4612	COG3618	amidohydrolase
Reut_B4613	COG3386	PFAM SMP-30 Gluconolaconase
Reut_B4615	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
Reut_B4616	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
Reut_B4617	COG1414	Transcriptional regulator
Reut_B4621	COG1132	(ABC) transporter
Reut_B4622	COG1132	(ABC) transporter
Reut_B4628	COG1960	acyl-CoA dehydrogenase activity
Reut_B4629	COG2186	Transcriptional regulator
Reut_B4631	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
Reut_B4631	COG3264	Mechanosensitive ion channel
Reut_B4639	COG0583	DNA-binding transcription factor activity
Reut_B4640	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
Reut_B4642	COG1609	Transcriptional regulator
Reut_B4646	COG4772	TonB-dependent receptor
Reut_B4651	COG3383	formate dehydrogenase (NAD+) activity
Reut_B4655	COG0583	DNA-binding transcription factor activity
Reut_B4659	COG4774	siderophore transport
Reut_B4662	COG4191	Histidine kinase
Reut_B4666	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
Reut_B4667	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
Reut_B4668	COG0179	Fumarylacetoacetate (FAA) hydrolase
Reut_B4669	COG1804	L-carnitine dehydratase bile acid-inducible protein F
Reut_B4670	COG1802	Transcriptional regulator
Reut_B4671	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
Reut_B4672	COG0861	Integral membrane protein TerC family
Reut_B4673	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
Reut_B4675	COG0697	spore germination
Reut_B4678	COG0179	Fumarylacetoacetate (FAA) hydrolase
Reut_B4680	COG1802	Transcriptional regulator
Reut_B4681	COG1335	isochorismatase
Reut_B4683	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
Reut_B4685	COG0583	DNA-binding transcription factor activity
Reut_B4687	COG1335	isochorismatase
Reut_B4698	COG0318	PFAM AMP-dependent synthetase and ligase
Reut_B4699	COG2188	Transcriptional regulator
Reut_B4708	COG0589	response to stress
Reut_B4711	COG3706	GGDEF domain
Reut_B4715	COG3246	L-lysine catabolic process to acetate
Reut_B4717	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
Reut_B4724	COG1309	transcriptional regulator
Reut_B4725	COG4221	oxidoreductase activity
Reut_B4726	COG0484	heat shock protein binding
Reut_B4729	COG0625	glutathione transferase activity
Reut_B4732	COG3321	synthase
Reut_B4732	COG1028	Short-chain dehydrogenase reductase Sdr
Reut_B4732	COG0604	alcohol dehydrogenase
Reut_B4734	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
Reut_B4734	COG2169	Transcriptional regulator
Reut_B4737	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
Reut_B4738	COG0183	Belongs to the thiolase family
Reut_B4742	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
Reut_B4742	COG4651	solute:proton antiporter activity
Reut_B4745	COG0589	response to stress
Reut_B4747	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
Reut_B4751	COG2175	clavaminate synthase activity
Reut_B4754	COG1028	Short-chain dehydrogenase reductase Sdr
Reut_B4758	COG0318	PFAM AMP-dependent synthetase and ligase
Reut_B4759	COG2909	trisaccharide binding
Reut_B4761	COG4459	periplasmic nitrate reductase
Reut_B4764	COG3043	anaerobic respiration
Reut_B4765	COG3005	denitrification pathway
Reut_B4772	COG3088	subunit of a heme lyase
Reut_B4773	COG4235	cytochrome complex assembly
Reut_B4774	COG0583	DNA-binding transcription factor activity
Reut_B4775	COG1028	Short-chain dehydrogenase reductase Sdr
Reut_B4776	COG2271	Major facilitator Superfamily
Reut_B4777	COG3959	Transketolase, thiamine diphosphate binding domain
Reut_B4778	COG3958	Transketolase
Reut_B4781	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
Reut_B4782	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
Reut_B4782	COG0473	3-isopropylmalate dehydrogenase activity
Reut_B4784	COG3384	dioxygenase
Reut_B4785	COG1804	L-carnitine dehydratase bile acid-inducible protein F
Reut_B4788	COG3181	Tripartite tricarboxylate transporter family receptor
Reut_B4790	COG1960	acyl-CoA dehydrogenase activity
Reut_B4791	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
Reut_B4791	COG0045	succinate-CoA ligase (ADP-forming) activity
Reut_B4791	COG1042	CoA-binding domain protein
Reut_B4792	COG1802	Transcriptional regulator
Reut_B4794	COG2159	amidohydrolase
Reut_B4798	COG1024	Enoyl-CoA hydratase
Reut_B4800	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
Reut_B4801	COG1802	Transcriptional regulator
Reut_B4802	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Reut_B4803	COG0156	8-amino-7-oxononanoate synthase activity
Reut_B4806	COG0404	The glycine cleavage system catalyzes the degradation of glycine
Reut_B4807	COG1760	l-serine dehydratase
Reut_B4808	COG0683	leucine binding
Reut_B4811	COG4175	Glycine betaine
Reut_B4817	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
Reut_B4818	COG0247	lactate metabolic process
Reut_B4818	COG2181	nitrate reductase activity
Reut_B4819	COG1902	pentaerythritol trinitrate reductase activity
Reut_B4819	COG0446	pyridine nucleotide-disulphide oxidoreductase
Reut_B4825	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
Reut_B4831	COG1760	l-serine dehydratase
Reut_B4836	COG0583	DNA-binding transcription factor activity
Reut_B4838	COG1252	NADH dehydrogenase
Reut_B4842	COG0066	3-isopropylmalate dehydratase activity
Reut_B4843	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
Reut_B4845	COG0477	Major facilitator Superfamily
Reut_B4846	COG0583	DNA-binding transcription factor activity
Reut_B4849	COG1574	metal-dependent hydrolase with the TIM-barrel fold
Reut_B4855	COG5006	permease, DMT superfamily
Reut_B4856	COG3181	Tripartite tricarboxylate transporter family receptor
Reut_B4858	COG1733	regulation of RNA biosynthetic process
Reut_B4859	COG2223	nitrite transmembrane transporter activity
Reut_B4860	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
Reut_B4861	COG2146	nitrite reductase [NAD(P)H] activity
Reut_B4862	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
Reut_B4863	COG0243	molybdopterin cofactor binding
Reut_B4864	COG2203	Gaf domain
Reut_B4864	COG5001	Diguanylate cyclase
Reut_B4864	COG3706	GGDEF domain
Reut_B4864	COG4251	negative regulation of phosphorylation
Reut_B4865	COG2814	Major facilitator Superfamily
Reut_B4866	COG4772	TonB-dependent receptor
Reut_B4869	COG1012	belongs to the aldehyde dehydrogenase family
Reut_B4870	COG1024	Enoyl-CoA hydratase
Reut_B4872	COG2814	Major facilitator Superfamily
Reut_B4886	COG1116	anion transmembrane transporter activity
Reut_B4887	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
Reut_B4888	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
Reut_B4888	COG1116	anion transmembrane transporter activity
Reut_B4889	COG0477	Major facilitator Superfamily
Reut_B4890	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
Reut_B4891	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
Reut_B4892	COG1845	cytochrome c oxidase, subunit III
Reut_B4893	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
Reut_B4894	COG1113	amino acid transport
Reut_B4897	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Reut_B4898	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
Reut_B4901	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Reut_B4907	COG0545	Peptidyl-prolyl cis-trans isomerase
Reut_B4909	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
Reut_B4926	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
Reut_B4928	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
Reut_B4931	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
Reut_B4934	COG2267	carboxylic ester hydrolase activity
Reut_B4941	COG5002	protein histidine kinase activity
Reut_B4943	COG0745	RESPONSE REGULATOR receiver
Reut_B4951	COG1278	Cold shock
Reut_B4953	COG1562	ergosterol biosynthetic process
Reut_B4954	COG1657	PFAM Prenyltransferase squalene oxidase
Reut_B4956	COG0443	Heat shock 70 kDa protein
Reut_B4960	COG3706	GGDEF domain
Reut_B4961	COG1414	Transcriptional regulator
Reut_B4965	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
Reut_B4966	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
Reut_B4967	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
Reut_B4970	COG1366	Belongs to the anti-sigma-factor antagonist family
Reut_B4971	COG1366	Belongs to the anti-sigma-factor antagonist family
Reut_B4972	COG2172	sigma factor antagonist activity
Reut_B4974	COG2205	protein histidine kinase activity
Reut_B4974	COG0784	Response regulator, receiver
Reut_B4974	COG5002	protein histidine kinase activity
Reut_B4975	COG2205	protein histidine kinase activity
Reut_B4975	COG0784	Response regulator, receiver
Reut_B4980	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
Reut_B4982	COG0659	secondary active sulfate transmembrane transporter activity
Reut_B4984	COG0450	alkyl hydroperoxide reductase
Reut_B4985	COG0835	chemotaxis
Reut_B4985	COG0784	Response regulator, receiver
Reut_B4986	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
Reut_B4989	COG2252	PERMEase
Reut_B4990	COG2916	Histone family protein nucleoid-structuring protein H-NS
Reut_B4992	COG0583	DNA-binding transcription factor activity
Reut_B4993	COG2814	Major facilitator Superfamily
Reut_B5001	COG2223	nitrite transmembrane transporter activity
Reut_B5002	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
Reut_B5003	COG1140	nitrate reductase beta subunit
Reut_B5004	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
Reut_B5005	COG2181	nitrate reductase activity
Reut_B5006	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
Reut_B5007	COG0288	reversible hydration of carbon dioxide
Reut_B5008	COG0572	uridine kinase
Reut_B5012	COG2010	Cytochrome c
Reut_B5022	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
Reut_B5024	COG3485	protocatechuate 3,4-dioxygenase
Reut_B5025	COG3485	protocatechuate 3,4-dioxygenase
Reut_B5026	COG0583	DNA-binding transcription factor activity
Reut_B5029	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
Reut_B5031	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
Reut_B5032	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
Reut_B5033	COG0583	DNA-binding transcription factor activity
Reut_B5034	COG1414	Transcriptional regulator
Reut_B5036	COG3246	L-lysine catabolic process to acetate
Reut_B5038	COG0318	PFAM AMP-dependent synthetase and ligase
Reut_B5042	COG2201	protein-glutamate methylesterase activity
Reut_B5043	COG5002	protein histidine kinase activity
Reut_B5043	COG2205	protein histidine kinase activity
Reut_B5043	COG0784	Response regulator, receiver
Reut_B5044	COG2897	thiosulfate sulfurtransferase activity
Reut_B5046	COG1960	acyl-CoA dehydrogenase activity
Reut_B5047	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
Reut_B5049	COG2207	Transcriptional regulator
Reut_B5050	COG3181	Tripartite tricarboxylate transporter family receptor
Reut_B5051	COG3246	L-lysine catabolic process to acetate
Reut_B5054	COG2175	clavaminate synthase activity
Reut_B5057	COG3604	Transcriptional regulator
Reut_B5061	COG2070	2-Nitropropane dioxygenase
Reut_B5062	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
Reut_B5065	COG3850	Histidine kinase
Reut_B5066	COG2197	response regulator
Reut_B5077	COG2204	response regulator
Reut_B5078	COG1028	Short-chain dehydrogenase reductase Sdr
Reut_B5082	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
Reut_B5087	COG0840	transmembrane signaling receptor activity
Reut_B5091	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
Reut_B5095	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
Reut_B5097	COG1766	The M ring may be actively involved in energy transduction
Reut_B5098	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
Reut_B5102	COG3144	bacterial-type flagellum assembly
Reut_B5105	COG3791	Glutathione-dependent formaldehyde-activating
Reut_B5109	COG0840	transmembrane signaling receptor activity
Reut_B5111	COG1739	Uncharacterized protein family UPF0029
Reut_B5115	COG2124	cytochrome p450
Reut_B5116	COG0656	L-ascorbic acid biosynthetic process
Reut_B5117	COG0583	DNA-binding transcription factor activity
Reut_B5122	COG2271	Major facilitator Superfamily
Reut_B5124	COG1764	response to oxidative stress
Reut_B5126	COG1028	Short-chain dehydrogenase reductase Sdr
Reut_B5128	COG2070	2-Nitropropane dioxygenase
Reut_B5134	COG1278	Cold shock
Reut_B5137	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
Reut_B5139	COG1802	Transcriptional regulator
Reut_B5140	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
Reut_B5141	COG2271	Major facilitator Superfamily
Reut_B5142	COG0154	amidase activity
Reut_B5143	COG2271	Major facilitator Superfamily
Reut_B5148	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
Reut_B5149	COG0583	DNA-binding transcription factor activity
Reut_B5164	COG1477	protein flavinylation
Reut_B5170	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
Reut_B5173	COG0577	efflux transmembrane transporter activity
Reut_B5173	COG1136	(ABC) transporter
Reut_B5178	COG0477	Major facilitator Superfamily
Reut_B5185	COG1278	Cold shock
Reut_B5194	COG0459	protein refolding
Reut_B5195	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
Reut_B5197	COG0640	Transcriptional regulator
Reut_B5199	COG0583	DNA-binding transcription factor activity
Reut_B5201	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
Reut_B5202	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
Reut_B5203	COG1042	CoA-binding domain protein
Reut_B5203	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
Reut_B5203	COG0045	succinate-CoA ligase (ADP-forming) activity
Reut_B5210	COG1272	protein, Hemolysin III
Reut_B5211	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
Reut_B5212	COG1477	protein flavinylation
Reut_B5216	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
Reut_B5217	COG1473	amidohydrolase
Reut_B5224	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
Reut_B5230	COG0840	transmembrane signaling receptor activity
Reut_B5233	COG0667	Aldo Keto reductase
Reut_B5237	COG1538	Outer membrane efflux protein
Reut_B5242	COG0137	argininosuccinate synthase activity
Reut_B5243	COG1804	L-carnitine dehydratase bile acid-inducible protein F
Reut_B5245	COG1024	Enoyl-CoA hydratase
Reut_B5246	COG0583	DNA-binding transcription factor activity
Reut_B5262	COG2885	chlorophyll binding
Reut_B5277	COG3181	Tripartite tricarboxylate transporter family receptor
Reut_B5279	COG1012	belongs to the aldehyde dehydrogenase family
Reut_B5280	COG0583	DNA-binding transcription factor activity
Reut_B5283	COG1024	Enoyl-CoA hydratase
Reut_B5284	COG0318	PFAM AMP-dependent synthetase and ligase
Reut_B5285	COG1960	acyl-CoA dehydrogenase activity
Reut_B5288	COG1960	acyl-CoA dehydrogenase activity
Reut_B5289	COG1028	Short-chain dehydrogenase reductase Sdr
Reut_B5290	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
Reut_B5291	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
Reut_B5292	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
Reut_B5294	COG3321	synthase
Reut_B5294	COG0604	alcohol dehydrogenase
Reut_B5298	COG2721	sulfolactate sulfo-lyase activity
Reut_B5300	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
Reut_B5307	COG3181	Tripartite tricarboxylate transporter family receptor
Reut_B5309	COG0318	PFAM AMP-dependent synthetase and ligase
Reut_B5310	COG0583	DNA-binding transcription factor activity
Reut_B5311	COG1414	Transcriptional regulator
Reut_B5312	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
Reut_B5316	COG0612	Peptidase, M16
Reut_B5319	COG1960	acyl-CoA dehydrogenase activity
Reut_B5321	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
Reut_B5325	COG0642	Histidine kinase
Reut_B5326	COG0745	RESPONSE REGULATOR receiver
Reut_B5328	COG0363	glucosamine-6-phosphate deaminase activity
Reut_B5329	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
Reut_B5331	COG0668	transmembrane transport
Reut_B5335	COG1959	2 iron, 2 sulfur cluster binding
Reut_B5335	COG1295	ribonuclease BN
Reut_B5339	COG2252	PERMEase
Reut_B5340	COG1278	Cold shock
Reut_B5342	COG1278	Cold shock
Reut_B5343	COG1192	Involved in chromosome partitioning
Reut_B5344	COG1475	DNA binding
Reut_B5351	COG3135	benzoate transporter
Reut_B5360	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
Reut_B5362	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
Reut_B5365	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
Reut_B5368	COG3206	protein involved in exopolysaccharide biosynthesis
Reut_B5368	COG0489	protein tyrosine kinase activity
Reut_B5369	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
Reut_B5370	COG1596	polysaccharide export
Reut_B5372	COG0438	transferase activity, transferring glycosyl groups
Reut_B5373	COG0367	asparagine synthase
Reut_B5374	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Reut_B5375	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
Reut_B5377	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
Reut_B5380	COG2197	response regulator
Reut_B5382	COG2807	transmembrane transport
Reut_B5384	COG0583	DNA-binding transcription factor activity
Reut_B5386	COG0066	3-isopropylmalate dehydratase activity
Reut_B5387	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
Reut_B5397	COG0583	DNA-binding transcription factor activity
Reut_B5409	COG4964	Belongs to the GSP D family
Reut_B5422	COG4771	TonB-dependent receptor
Reut_B5424	COG0456	acetyltransferase
Reut_B5425	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
Reut_B5426	COG3047	cAMP biosynthetic process
Reut_B5429	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
Reut_B5429	COG1918	ferrous iron import across plasma membrane
Reut_B5430	COG1918	ferrous iron import across plasma membrane
Reut_B5430	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
Reut_B5432	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
Reut_B5434	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
Reut_B5436	COG0583	DNA-binding transcription factor activity
Reut_B5437	COG1960	acyl-CoA dehydrogenase activity
Reut_B5438	COG3181	Tripartite tricarboxylate transporter family receptor
Reut_B5439	COG1804	L-carnitine dehydratase bile acid-inducible protein F
Reut_B5440	COG3181	Tripartite tricarboxylate transporter family receptor
Reut_B5443	COG0583	DNA-binding transcription factor activity
Reut_B5444	COG1028	Short-chain dehydrogenase reductase Sdr
Reut_B5445	COG1620	l-lactate permease
Reut_B5446	COG1139	Iron-sulfur cluster binding protein
Reut_B5448	COG0247	lactate metabolic process
Reut_B5449	COG2186	Transcriptional regulator
Reut_B5451	COG2197	response regulator
Reut_B5456	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
Reut_B5461	COG2072	flavoprotein involved in K transport
Reut_B5469	COG3706	GGDEF domain
Reut_B5470	COG0477	Major facilitator Superfamily
Reut_B5472	COG0006	proline dipeptidase activity
Reut_B5481	COG2271	Major facilitator Superfamily
Reut_B5484	COG1021	2,3-dihydroxybenzoate-AMP ligase
Reut_B5490	COG4303	Ethanolamine ammonia lyase large subunit
Reut_B5491	COG4302	ethanolamine ammonia-lyase activity
Reut_B5494	COG0583	DNA-binding transcription factor activity
Reut_B5495	COG0477	Major facilitator Superfamily
Reut_B5499	COG3971	2-oxopent-4-enoate hydratase activity
Reut_B5510	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
Reut_B5511	COG0583	DNA-binding transcription factor activity
Reut_B5512	COG3181	Tripartite tricarboxylate transporter family receptor
Reut_B5517	COG0114	fumarate hydratase activity
Reut_B5521	COG5001	Diguanylate cyclase
Reut_B5521	COG5002	protein histidine kinase activity
Reut_B5521	COG3447	MASE1 domain protein
Reut_B5522	COG5001	Diguanylate cyclase
Reut_B5522	COG3300	MHYT domain
Reut_B5523	COG3842	ATPase activity
Reut_B5524	COG1178	ABC-type Fe3 transport system permease component
Reut_B5525	COG1840	ABC-type Fe3 transport system, periplasmic component
Reut_B5528	COG0697	spore germination
Reut_B5530	COG0735	belongs to the Fur family
Reut_B5533	COG0583	DNA-binding transcription factor activity
Reut_B5539	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
Reut_B5541	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
Reut_B5546	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
Reut_B5547	COG0840	transmembrane signaling receptor activity
Reut_B5548	COG3284	Transcriptional regulator
Reut_B5549	COG3199	ATP-NAD kinase
Reut_B5550	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
Reut_B5551	COG0022	dehydrogenase e1 component
Reut_B5552	COG0508	dehydrogenase complex catalyzes the overall conversion of
Reut_B5552	COG0596	Alpha beta hydrolase
Reut_B5553	COG0095	Lipoate-protein ligase
Reut_B5557	COG2345	Transcriptional regulator
Reut_B5559	COG1764	response to oxidative stress
Reut_B5560	COG1846	Transcriptional regulator
Reut_B5561	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Reut_B5567	COG0714	Associated with various cellular activities
Reut_B5568	COG5285	phytanoyl-CoA dioxygenase
Reut_B5569	COG1414	Transcriptional regulator
Reut_B5570	COG0477	Major facilitator Superfamily
Reut_B5573	COG0762	integral membrane protein
Reut_B5576	COG0318	PFAM AMP-dependent synthetase and ligase
Reut_B5578	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
Reut_B5579	COG3360	Dodecin
Reut_B5583	COG0419	ATPase involved in DNA repair
Reut_B5586	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
Reut_B5591	COG1695	Transcriptional regulator
Reut_B5595	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
Reut_B5596	COG2916	Histone family protein nucleoid-structuring protein H-NS
Reut_B5597	COG0840	transmembrane signaling receptor activity
Reut_B5599	COG0745	RESPONSE REGULATOR receiver
Reut_B5600	COG0835	chemotaxis
Reut_B5601	COG0840	transmembrane signaling receptor activity
Reut_B5607	COG1360	Flagellar Motor Protein
Reut_B5608	COG2198	Histidine kinase
Reut_B5608	COG0643	Histidine kinase
Reut_B5610	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
Reut_B5613	COG0745	RESPONSE REGULATOR receiver
Reut_B5614	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
Reut_B5619	COG1191	sigma factor activity
Reut_B5625	COG1815	bacterial-type flagellum-dependent cell motility
Reut_B5626	COG1558	bacterial-type flagellum-dependent cell motility
Reut_B5627	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
Reut_B5628	COG1749	Flagellar hook protein flgE
Reut_B5630	COG4786	Flagellar basal body rod
Reut_B5633	COG3951	Flagellar rod assembly protein muramidase FlgJ
Reut_B5633	COG1705	Flagellar rod assembly protein muramidase FlgJ
Reut_B5634	COG1256	bacterial-type flagellum assembly
Reut_B5635	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
Reut_B5636	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
Reut_B5637	COG2986	histidine ammonia-lyase
Reut_B5642	COG1538	Outer membrane efflux protein
Reut_B5643	COG1309	transcriptional regulator
Reut_B5644	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
Reut_B5648	COG0583	DNA-binding transcription factor activity
Reut_B5649	COG2814	Major facilitator Superfamily
Reut_B5651	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
Reut_B5653	COG0583	DNA-binding transcription factor activity
Reut_B5658	COG0277	FAD linked oxidase domain protein
Reut_B5660	COG1012	belongs to the aldehyde dehydrogenase family
Reut_B5663	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
Reut_B5666	COG0523	cobalamin synthesis protein
Reut_B5667	COG0402	S-adenosylhomocysteine deaminase activity
Reut_B5670	COG1802	Transcriptional regulator
Reut_B5674	COG0543	2 iron, 2 sulfur cluster binding
Reut_B5674	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
Reut_B5695	COG0583	DNA-binding transcription factor activity
Reut_B5704	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
Reut_B5709	COG0662	Cupin 2, conserved barrel domain protein
Reut_B5710	COG3012	SEC-C Motif Domain Protein
Reut_B5710	COG3318	Belongs to the UPF0149 family
Reut_B5712	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
Reut_B5714	COG0251	oxidation-reduction process
Reut_B5716	COG2271	Major facilitator Superfamily
Reut_B5720	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
Reut_B5721	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
Reut_B5722	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
Reut_B5725	COG1560	Kdo2-lipid A biosynthetic process
Reut_B5754	COG0583	DNA-binding transcription factor activity
Reut_B5756	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
Reut_B5757	COG1228	amidohydrolase
Reut_B5759	COG2031	fatty acid transporter
Reut_B5760	COG2423	ornithine cyclodeaminase activity
Reut_B5761	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
Reut_B5761	COG1017	nitric oxide dioxygenase activity
Reut_B5762	COG0583	DNA-binding transcription factor activity
Reut_B5764	COG3119	arylsulfatase activity
Reut_B5765	COG0277	FAD linked oxidase domain protein
Reut_B5768	COG1802	Transcriptional regulator
Reut_B5769	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
Reut_B5770	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
Reut_B5771	COG0412	Dienelactone hydrolase
Reut_B5772	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
Reut_B5773	COG0473	3-isopropylmalate dehydrogenase activity
Reut_B5773	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
Reut_B5775	COG3384	dioxygenase
Reut_B5776	COG2159	amidohydrolase
Reut_B5782	COG3618	amidohydrolase
Reut_B5786	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
Reut_B5790	COG1053	succinate dehydrogenase
Reut_B5790	COG3976	FMN-binding domain protein
Reut_B5798	COG1802	Transcriptional regulator
Reut_B5801	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
Reut_B5804	COG0625	glutathione transferase activity
Reut_B5805	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
Reut_B5806	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
Reut_B5808	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
Reut_B5809	COG0179	Fumarylacetoacetate (FAA) hydrolase
Reut_B5812	COG1473	amidohydrolase
Reut_B5815	COG0531	amino acid
Reut_B5830	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
Reut_B5834	COG2303	Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate
Reut_B5836	COG4638	Rieske (2fe-2S)
Reut_B5839	COG0583	DNA-binding transcription factor activity
Reut_B5842	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
Reut_B5844	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Reut_B5844	COG2205	protein histidine kinase activity
Reut_B5845	COG2197	response regulator
Reut_B5847	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
Reut_B5847	COG2885	chlorophyll binding
Reut_B5848	COG1609	Transcriptional regulator
Reut_B5853	COG3246	L-lysine catabolic process to acetate
Reut_B5855	COG3485	protocatechuate 3,4-dioxygenase
Reut_B5856	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Reut_B5857	COG1136	(ABC) transporter
Reut_B5857	COG0577	efflux transmembrane transporter activity
Reut_B5860	COG2271	Major facilitator Superfamily
Reut_B5861	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
Reut_B5862	COG0625	glutathione transferase activity
Reut_B5866	COG0251	oxidation-reduction process
Reut_B5867	COG3706	GGDEF domain
Reut_B5869	COG1690	Belongs to the RtcB family
Reut_B5870	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
Reut_B5873	COG3842	ATPase activity
Reut_B5874	COG1840	ABC-type Fe3 transport system, periplasmic component
Reut_B5877	COG1012	belongs to the aldehyde dehydrogenase family
Reut_B5878	COG0686	Belongs to the AlaDH PNT family
Reut_B5883	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
Reut_B5885	COG1580	Controls the rotational direction of flagella during chemotaxis
Reut_C5886	COG1024	Enoyl-CoA hydratase
Reut_C5891	COG0583	DNA-binding transcription factor activity
Reut_C5892	COG1609	Transcriptional regulator
Reut_C5894	COG0129	dihydroxy-acid dehydratase activity
Reut_C5896	COG3181	Tripartite tricarboxylate transporter family receptor
Reut_C5897	COG4948	Mandelate Racemase Muconate Lactonizing
Reut_C5899	COG0473	3-isopropylmalate dehydrogenase activity
Reut_C5900	COG2084	Dehydrogenase
Reut_C5901	COG1012	belongs to the aldehyde dehydrogenase family
Reut_C5903	COG2186	Transcriptional regulator
Reut_C5912	COG4977	sequence-specific DNA binding
Reut_C5916	COG0542	response to heat
Reut_C5928	COG3971	2-oxopent-4-enoate hydratase activity
Reut_C5931	COG0251	oxidation-reduction process
Reut_C5932	COG3181	Tripartite tricarboxylate transporter family receptor
Reut_C5933	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
Reut_C5935	COG1012	belongs to the aldehyde dehydrogenase family
Reut_C5939	COG0318	PFAM AMP-dependent synthetase and ligase
Reut_C5941	COG2814	Major facilitator Superfamily
Reut_C5943	COG0183	Belongs to the thiolase family
Reut_C5945	COG1309	transcriptional regulator
Reut_C5946	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
Reut_C5947	COG1802	Transcriptional regulator
Reut_C5950	COG1804	L-carnitine dehydratase bile acid-inducible protein F
Reut_C5952	COG0604	alcohol dehydrogenase
Reut_C5956	COG0411	ABC transporter
Reut_C5973	COG2274	protein secretion by the type I secretion system
Reut_C5974	COG4804	nuclease activity
Reut_C5978	COG3181	Tripartite tricarboxylate transporter family receptor
Reut_C5980	COG3483	tryptophan 2,3-dioxygenase activity
Reut_C5981	COG0154	amidase activity
Reut_C5983	COG0583	DNA-binding transcription factor activity
Reut_C5986	COG0655	NAD(P)H dehydrogenase (quinone) activity
Reut_C5998	COG4115	mRNA cleavage
Reut_C6005	COG2916	Histone family protein nucleoid-structuring protein H-NS
Reut_C6013	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
Reut_C6014	COG1278	Cold shock
Reut_C6017	COG5002	protein histidine kinase activity
Reut_C6017	COG3447	MASE1 domain protein
Reut_C6017	COG5001	Diguanylate cyclase
Reut_C6018	COG1028	Short-chain dehydrogenase reductase Sdr
Reut_C6028	COG1278	Cold shock
Reut_C6029	COG1215	transferase activity, transferring glycosyl groups
Reut_C6036	COG1028	Short-chain dehydrogenase reductase Sdr
Reut_C6037	COG1024	Enoyl-CoA hydratase
Reut_C6039	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
Reut_C6046	COG2814	Major facilitator Superfamily
Reut_C6050	COG3181	Tripartite tricarboxylate transporter family receptor
Reut_C6051	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
Reut_C6058	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
Reut_C6059	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
Reut_C6060	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
Reut_C6062	COG0183	Belongs to the thiolase family
Reut_C6065	COG0318	PFAM AMP-dependent synthetase and ligase
Reut_C6066	COG1960	acyl-CoA dehydrogenase activity
Reut_C6067	COG0702	epimerase
Reut_C6069	COG3246	L-lysine catabolic process to acetate
Reut_C6083	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
Reut_C6084	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
Reut_C6085	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
Reut_C6087	COG2721	sulfolactate sulfo-lyase activity
Reut_C6088	COG2721	sulfolactate sulfo-lyase activity
Reut_C6089	COG1063	alcohol dehydrogenase
Reut_C6090	COG0477	Major facilitator Superfamily
Reut_C6093	COG1609	Transcriptional regulator
Reut_C6098	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
Reut_C6102	COG0300	oxidoreductase activity
Reut_C6104	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Reut_C6106	COG1024	Enoyl-CoA hydratase
Reut_C6107	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
Reut_C6108	COG1028	Short-chain dehydrogenase reductase Sdr
Reut_C6109	COG0318	PFAM AMP-dependent synthetase and ligase
Reut_C6110	COG1902	pentaerythritol trinitrate reductase activity
Reut_C6110	COG0446	pyridine nucleotide-disulphide oxidoreductase
Reut_C6111	COG1846	Transcriptional regulator
Reut_C6114	COG2207	Transcriptional regulator
Reut_C6117	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
Reut_C6125	COG0583	DNA-binding transcription factor activity
Reut_C6126	COG0583	DNA-binding transcription factor activity
Reut_C6127	COG3608	succinylglutamate desuccinylase aspartoacylase
Reut_C6128	COG2814	Major facilitator Superfamily
Reut_C6129	COG0251	oxidation-reduction process
Reut_C6133	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
Reut_C6140	COG1028	Short-chain dehydrogenase reductase Sdr
Reut_C6140	COG0604	alcohol dehydrogenase
Reut_C6140	COG3321	synthase
Reut_C6150	COG2129	metallophosphoesterase
Reut_C6151	COG1074	ATP-dependent DNA helicase activity
Reut_C6162	COG1192	Involved in chromosome partitioning
Reut_C6163	COG1475	DNA binding
Reut_C6164	COG4974	Belongs to the 'phage' integrase family
Reut_C6166	COG1672	PFAM Archaeal ATPase
Reut_C6166	COG2114	Pfam Adenylate and Guanylate cyclase catalytic domain
Reut_C6169	COG2843	Capsule synthesis protein
Reut_C6172	COG0145	ligase activity
Reut_C6173	COG0146	N-methylhydantoinase B acetone carboxylase alpha subunit
Reut_C6174	COG4647	ligase activity
Reut_C6175	COG0318	PFAM AMP-dependent synthetase and ligase
Reut_C6177	COG4456	Virulence-associated protein
Reut_C6185	COG0318	PFAM AMP-dependent synthetase and ligase
Reut_C6189	COG1254	Belongs to the acylphosphatase family
Reut_C6193	COG2326	polyphosphate kinase activity
Reut_C6194	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
Reut_C6197	COG1812	S-adenosylmethionine synthetase (AdoMet synthetase)
Reut_C6198	COG1704	LemA family
Reut_C6199	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
Reut_C6203	COG1846	Transcriptional regulator
Reut_C6205	COG1566	PFAM secretion protein HlyD family protein
Reut_C6206	COG2814	Major facilitator Superfamily
Reut_C6209	COG0583	DNA-binding transcription factor activity
Reut_C6212	COG0559	Belongs to the binding-protein-dependent transport system permease family
Reut_C6217	COG1522	sequence-specific DNA binding
Reut_C6219	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
Reut_C6223	COG0145	ligase activity
Reut_C6224	COG1028	Short-chain dehydrogenase reductase Sdr
Reut_C6225	COG1028	Short-chain dehydrogenase reductase Sdr
Reut_C6226	COG3246	L-lysine catabolic process to acetate
Reut_C6228	COG2814	Major facilitator Superfamily
Reut_C6229	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
Reut_C6230	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
Reut_C6231	COG0402	S-adenosylhomocysteine deaminase activity
Reut_C6233	COG0179	Fumarylacetoacetate (FAA) hydrolase
Reut_C6236	COG2335	COG2335, Secreted and surface protein containing fasciclin-like repeats
Reut_C6237	COG3040	lipid binding
Reut_C6240	COG0840	transmembrane signaling receptor activity
Reut_C6247	COG0583	DNA-binding transcription factor activity
Reut_C6248	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Reut_C6249	COG1804	L-carnitine dehydratase bile acid-inducible protein F
Reut_C6250	COG3181	Tripartite tricarboxylate transporter family receptor
Reut_C6252	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
Reut_C6255	COG1024	Enoyl-CoA hydratase
Reut_C6256	COG1804	L-carnitine dehydratase bile acid-inducible protein F
Reut_C6262	COG1414	Transcriptional regulator
Reut_C6268	COG0559	Belongs to the binding-protein-dependent transport system permease family
Reut_C6270	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
Reut_C6278	COG2267	carboxylic ester hydrolase activity
Reut_C6279	COG2072	flavoprotein involved in K transport
Reut_C6280	COG1250	3-hydroxyacyl-CoA dehydrogenase
Reut_C6281	COG1028	Short-chain dehydrogenase reductase Sdr
Reut_C6285	COG1024	Enoyl-CoA hydratase
Reut_C6287	COG2249	NAD(P)H dehydrogenase (quinone) activity
Reut_C6289	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
Reut_C6296	COG1028	Short-chain dehydrogenase reductase Sdr
Reut_C6298	COG1960	acyl-CoA dehydrogenase activity
Reut_C6299	COG1024	Enoyl-CoA hydratase
Reut_C6300	COG1804	L-carnitine dehydratase bile acid-inducible protein F
Reut_C6302	COG1960	acyl-CoA dehydrogenase activity
Reut_C6303	COG2271	Major facilitator Superfamily
Reut_C6305	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
Reut_C6308	COG3181	Tripartite tricarboxylate transporter family receptor
Reut_C6310	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
Reut_C6314	COG2368	4-hydroxyphenylacetate
Reut_C6315	COG1028	Short-chain dehydrogenase reductase Sdr
Reut_C6317	COG1804	L-carnitine dehydratase bile acid-inducible protein F
Reut_C6325	COG1028	Short-chain dehydrogenase reductase Sdr
Reut_C6327	COG0411	ABC transporter
Reut_C6329	COG0559	Belongs to the binding-protein-dependent transport system permease family
Reut_C6331	COG1104	cysteine desulfurase activity
Reut_C6332	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
Reut_C6334	COG2207	Transcriptional regulator
Reut_C6334	COG1917	Cupin 2, conserved barrel domain protein
Reut_C6338	COG3436	PFAM IS66 Orf2 family protein
Reut_C6347	COG2916	Histone family protein nucleoid-structuring protein H-NS
Reut_C6349	COG4804	nuclease activity
Reut_C6351	COG2030	dehydratase
Reut_C6352	COG0372	Belongs to the citrate synthase family
Reut_C6354	COG0477	Major facilitator Superfamily
Reut_C6357	COG2721	sulfolactate sulfo-lyase activity
Reut_C6359	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
Reut_C6360	COG0604	alcohol dehydrogenase
Reut_C6360	COG3321	synthase
Reut_C6362	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
Reut_C6363	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
Reut_C6364	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
Reut_C6365	COG1028	Short-chain dehydrogenase reductase Sdr
Reut_C6366	COG1960	acyl-CoA dehydrogenase activity
Reut_C6368	COG1960	acyl-CoA dehydrogenase activity
Reut_C6369	COG1250	3-hydroxyacyl-CoA dehydrogenase
Reut_C6370	COG0583	DNA-binding transcription factor activity
Reut_C6374	COG1012	belongs to the aldehyde dehydrogenase family
Reut_C6382	COG2916	Histone family protein nucleoid-structuring protein H-NS
Reut_C6387	COG0251	oxidation-reduction process
Reut_C6390	COG2409	Drug exporters of the RND superfamily
Reut_C6395	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
Reut_C6395	COG4221	oxidoreductase activity
Reut_C6395	COG0300	oxidoreductase activity
Reut_C6395	COG3321	synthase
Reut_C6396	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
Reut_C6399	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
Reut_C6403	COG1028	Short-chain dehydrogenase reductase Sdr
Reut_C6404	COG1028	Short-chain dehydrogenase reductase Sdr
Reut_C6406	COG1028	Short-chain dehydrogenase reductase Sdr
Reut_C6407	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
Reut_C6408	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
Reut_C6409	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
Reut_C6410	COG0739	heme binding
Reut_C6413	COG5002	protein histidine kinase activity
Reut_C6413	COG2198	Histidine kinase
Reut_C6413	COG0784	Response regulator, receiver
Reut_C6418	COG0464	growth
Reut_C6424	COG0318	PFAM AMP-dependent synthetase and ligase
Reut_C6425	COG1960	acyl-CoA dehydrogenase activity
Reut_C6427	COG4670	ketone body catabolic process
Reut_C6430	COG0583	DNA-binding transcription factor activity
Reut_C6434	COG0559	Belongs to the binding-protein-dependent transport system permease family
Reut_C6435	COG0410	ABC transporter
Reut_C6440	COG0477	Major facilitator Superfamily
Reut_D6453	COG3077	Addiction module antitoxin, RelB DinJ family
Reut_D6454	COG3041	Addiction module toxin RelE StbE family
Reut_D6456	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
Reut_D6476	COG1024	Enoyl-CoA hydratase
Reut_D6477	COG1414	Transcriptional regulator
Reut_D6481	COG0183	Belongs to the thiolase family
Reut_D6486	COG1028	Short-chain dehydrogenase reductase Sdr
Reut_D6488	COG0559	Belongs to the binding-protein-dependent transport system permease family
Reut_D6494	COG0789	Transcriptional regulator
Reut_D6496	COG2608	mercury ion transmembrane transporter activity
Reut_D6497	COG2608	mercury ion transmembrane transporter activity
Reut_D6498	COG0789	Transcriptional regulator
Reut_D6502	COG4962	Type ii secretion system protein e
Reut_D6503	COG3838	Conjugal transfer protein Trbc
Reut_D6504	COG5268	conjugation
Reut_D6505	COG3451	type IV secretory pathway VirB4
Reut_D6523	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone