locus-tag class description LH89_00035 ENOG4105UZW Tail fiber assembly protein LH89_00045 ENOG4108C33 Resolvase LH89_00055 ENOG4108DG9 Smr protein MutS2 LH89_00060 ENOG4105D2S major facilitator superfamily LH89_00115 ENOG4105VZ1 Replication Protein LH89_00120 ENOG4105KSC Transcriptional regulator, TraR DksA family LH89_00145 ENOG4105C8Q Methyl-accepting chemotaxis LH89_00150 ENOG4105UVW uncharacterized protein yebW LH89_00155 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B LH89_00160 ENOG4105DY2 Paraquat-inducible protein b LH89_00165 ENOG4105H2K paraquat-inducible protein a LH89_00170 ENOG4108ZGC gaf domain protein LH89_00175 ENOG41073DY may be a structural element that influences the osmotic activation of ProP at a post-translational level (By similarity) LH89_00180 ENOG4105CN1 protease LH89_00195 ENOG4105WH1 Two component transcriptional regulator luxr family LH89_00200 ENOG4105BZU Histidine kinase LH89_00205 ENOG4105DQQ Major facilitator superfamily MFS_1 LH89_00210 ENOG4105CRU nitrate reductase, alpha subunit LH89_00215 ENOG4108IUE nitrate reductase beta subunit LH89_00220 ENOG4105R3A Nitrate reductase LH89_00225 ENOG41076YT nitrate reductase, gamma subunit LH89_00235 ENOG4105C0A alcohol dehydrogenase LH89_00270 ENOG4105HEI LysR family (Transcriptional regulator LH89_00285 ENOG410814C multidrug resistance protein LH89_00290 ENOG4105EJC lysr family transcriptional regulator LH89_00295 ENOG4105DQ4 alcohol dehydrogenase LH89_00300 ENOG4107GJV short-chain dehydrogenase reductase LH89_00310 ENOG4105WBD 4-oxalocrotonate tautomerase LH89_00315 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) LH89_00325 ENOG4108JPW Aminotransferase LH89_00330 ENOG4105C26 Dehydrogenase LH89_00340 ENOG4105F38 ABC transporter, permease LH89_00360 ENOG4105E0K tonB-dependent siderophore receptor LH89_00365 ENOG4105N2W Transcriptional regulator LH89_00370 ENOG4107TK4 histidinol-phosphate phosphatase LH89_00375 ENOG4106UW1 Major Facilitator superfamily LH89_00380 ENOG4108HCJ Hydrolase LH89_00390 ENOG4105CDA abc transporter atp-binding protein LH89_00395 ENOG4105E5Q amino acid AbC transporter LH89_00400 ENOG4105E5Q amino acid AbC transporter LH89_00405 ENOG4105C28 cystathionine LH89_00425 ENOG4105C8Q Methyl-accepting chemotaxis LH89_00430 ENOG4105C8Q Methyl-accepting chemotaxis LH89_00440 ENOG4108DQG in Escherichia coli SbmA is involved in uptake of microcin J25 LH89_00465 ENOG4108HHI Type III secretion system protein LH89_00495 ENOG4108HR8 type iii secretion LH89_00505 ENOG4105I6B RNA polymerase LH89_00510 ENOG4105ENE Histidine kinase LH89_00515 ENOG4105WH1 Two component transcriptional regulator luxr family LH89_00550 ENOG4105CVE Lytic murein transglycosylase LH89_00615 ENOG4105D5K Hemolysin activator protein LH89_00675 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) LH89_00680 ENOG4105EZE Cupin 4 family protein LH89_00685 ENOG4105IFJ Histidine kinase LH89_00695 ENOG4107QTF adenylosuccinate lyase LH89_00700 ENOG41075W9 High frequency lysogenization protein HflD homolog LH89_00705 ENOG4105CCJ Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity) LH89_00715 ENOG4108R99 pseudouridine synthase LH89_00720 ENOG4108HMX isocitrate dehydrogenase (NADP) LH89_00725 ENOG4105BZU Histidine kinase LH89_00730 ENOG4105D0M Protease HtpX homolog LH89_00735 ENOG4105CAZ oligogalacturonide lyase LH89_00745 ENOG41064PC LH89_00750 ENOG4105C22 threonyL-tRNA synthetase LH89_00755 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) LH89_00760 ENOG41082NX 50s ribosomal protein l35 LH89_00765 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) LH89_00770 ENOG4105CSS phenylalanyl-tRNA synthetase (alpha subunit) LH89_00775 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) LH89_00780 ENOG4108ZUF This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) LH89_00785 ENOG4105VXR cytoplasmic protein LH89_00795 ENOG4107RA1 nh(3)-dependent nad( ) synthetase LH89_00800 ENOG4105KKI DNA-binding transcriptional activator OsmE LH89_00805 ENOG4108ETY sodium dicarboxylate symporter LH89_00810 ENOG4107K5X Membrane-bound metal-dependent hydrolase LH89_00820 ENOG4108PU9 oligogalacturonate-specific porin LH89_00835 ENOG4105F66 Binding-protein-dependent transport systems inner membrane component LH89_00840 ENOG4105DB9 Binding-protein-dependent transport systems inner membrane component LH89_00845 ENOG41061NF Pectate lyase LH89_00850 ENOG4105CHR reductase LH89_00855 ENOG4105D50 Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate (By similarity) LH89_00860 ENOG4105M5J Cupin 2, conserved barrel domain protein LH89_00865 ENOG4107PN8 YfeABCD locus regulator LH89_00870 ENOG4105FGM Fructosamine kinase LH89_00875 ENOG4105VEQ Cold shock protein LH89_00880 ENOG4105DHI Methyltransferase LH89_00885 ENOG4108UI1 Probably functions as a manganese efflux pump (By similarity) LH89_00895 ENOG4105F3R pts system mannose fructose sorbose family iid LH89_00900 ENOG4105ETZ PTS System LH89_00905 ENOG4108EQA pts system LH89_00910 ENOG4105EE5 Membrane protein terC LH89_00915 ENOG4105C8Q Methyl-accepting chemotaxis LH89_00920 ENOG4105EJQ L-serine dehydratase LH89_00925 ENOG4105P8F nudix hydrolase LH89_00935 ENOG4105X5C UPF0181 protein LH89_00940 ENOG4105M4H endoribonuclease L-psp LH89_00945 ENOG4105DVT helicase LH89_00950 ENOG41072GX Peptidase M22 Glycoprotease LH89_00955 ENOG4105Y4Z Outer Membrane Lipoprotein LH89_00960 ENOG4105CEY Amp-dependent synthetase and ligase LH89_00965 ENOG4105ZIE Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity) LH89_00970 ENOG4105VJP Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell (By similarity) LH89_00975 ENOG4107QMS site-determining protein LH89_00980 ENOG4105K7U Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) LH89_00990 ENOG4105FBJ fumarylacetoacetate (faa) hydrolase LH89_00995 ENOG4108ZZ3 UPF0260 protein LH89_01000 ENOG410635M Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein (By similarity) LH89_01005 ENOG4105C05 Multifunctional regulator of fatty acid metabolism (By similarity) LH89_01010 ENOG4105ED1 spovr family LH89_01015 ENOG4105MWK D-amino acid dehydrogenase, small subunit LH89_01025 ENOG4106QAN LH89_01055 ENOG4108RU0 short-chain dehydrogenase reductase LH89_01090 ENOG4105DSY exodeoxyribonuclease V, gamma LH89_01095 ENOG4107QKA exodeoxyribonuclease V beta LH89_01100 ENOG4107QYX exodeoxyribonuclease v alpha LH89_01105 ENOG4105BZU Histidine kinase LH89_01120 ENOG4105I6B RNA polymerase LH89_01130 ENOG4105C1J atp-dependent rna helicase LH89_01140 ENOG4105C3G gtp-binding protein LH89_01145 ENOG4108ZPD The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity) LH89_01150 ENOG4105MGX transcription activated by CRP (cyclic AMP receptor protein), a global transcription factor involved in regulation of metabolism in enteric bacteria LH89_01155 ENOG4105EJC lysr family transcriptional regulator LH89_01165 ENOG4105C5T Phosphoribosyl pyrophosphate synthase LH89_01170 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) LH89_01175 ENOG4105C1U Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein (By similarity) LH89_01180 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) LH89_01185 ENOG4105C8K Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity) LH89_01190 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) LH89_01195 ENOG41063JG Transcriptional regulator LH89_01200 ENOG4105CXR Phospho-2-dehydro-3-deoxyoctonate aldolase LH89_01205 ENOG4105C5D exported protein LH89_01210 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) LH89_01215 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) LH89_01220 ENOG4105Q9Y Universal stress protein LH89_01225 ENOG4105DS0 Transcriptional regulator, Crp Fnr family LH89_01230 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) LH89_01235 ENOG4105C8Q Methyl-accepting chemotaxis LH89_01250 ENOG4105C8Q Methyl-accepting chemotaxis LH89_01260 ENOG4105PY6 Phenolic acid decarboxylase LH89_01275 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) LH89_01280 ENOG4105S9S Binding-protein-dependent transport systems, inner membrane component LH89_01285 ENOG4105F38 ABC transporter, permease LH89_01300 ENOG4108QXE glycerophosphoryl diester phosphodiesterase LH89_01310 ENOG4106I9T LH89_01340 ENOG4105ECR NmrA family LH89_01385 ENOG4105DFH Transport of potassium into the cell (By similarity) LH89_01420 ENOG4105F1S paraquat-inducible protein a LH89_01440 ENOG4108YQE rare lipoprotein a LH89_01465 ENOG4105C3Q Glycosyl transferase, family 2 LH89_01470 ENOG4105F2W methyltransferase LH89_01475 ENOG4105EMU Dehydrogenase LH89_01485 ENOG4105X1V Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) LH89_01505 ENOG4105CHR reductase LH89_01520 ENOG4105DXI Major Facilitator superfamily LH89_01525 ENOG4105M5Q UPF0482 protein LH89_01530 ENOG4105KBG Protein of unknown function (DUF1161) LH89_01535 ENOG4105EWW Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) LH89_01540 ENOG4105DAG ROK family LH89_01545 ENOG4106NZI LysR family Transcriptional regulator LH89_01550 ENOG4105D94 Major Facilitator Superfamily LH89_01555 ENOG4105KR1 Trans-acting protein required for termination of DNA replication. Binds to DNA replication terminator sequences (terA to terF) to prevent the passage of replication forks. The termination efficiency will be affected by the affinity of this protein for the terminator sequence (By similarity) LH89_01560 ENOG4105C9Q fumarate hydratase class II LH89_01565 ENOG4105EIP mannose-6-phosphate isomerase LH89_01570 ENOG4106J39 exported protein LH89_01580 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) LH89_01590 ENOG4105DHU Bile acid LH89_01595 ENOG4105D9R oxidoreductase LH89_01605 ENOG4105CNN ABC, transporter LH89_01610 ENOG4105C2J ABC transporter LH89_01615 ENOG4105DMK Periplasmic binding protein LacI transcriptional regulator LH89_01620 ENOG4105EF1 ribulokinase LH89_01625 ENOG4105CAC Catalyzes the conversion of L-arabinose to L-ribulose (By similarity) LH89_01630 ENOG4105QZ5 OriC-binding nucleoid-associated protein LH89_01635 ENOG4105DGN Electron transport complex LH89_01640 ENOG4108R3D Electron transport complex LH89_01645 ENOG4107QTR Required for nitrogen fixation. May be part of a membrane complex functioning as an intermediate in the electron transport to nitrogenase (By similarity) LH89_01650 ENOG4105D6A Electron transport complex LH89_01655 ENOG4108UQQ Electron transport complex LH89_01665 ENOG4105CSM endonuclease III LH89_01670 ENOG4107R11 Transcriptional regulator LH89_01675 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) LH89_01680 ENOG4105RKX Protein of unknown function (DUF2498) LH89_01690 ENOG4105ERU peptidase LH89_01695 ENOG4105UBK short-chain dehydrogenase reductase LH89_01700 ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase LH89_01705 ENOG4105FE9 pseudouridine synthase LH89_01710 ENOG4107RTD sua5 ycio yrdc ywlc family protein LH89_01715 ENOG4105DB7 PHP domain protein LH89_01725 ENOG4105DDQ anthranilate synthase LH89_01730 ENOG4108I0Q anthranilate phosphoribosyltransferase LH89_01735 ENOG4105DK0 Indole-3-glycerol phosphate synthase LH89_01740 ENOG4105CG0 The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity) LH89_01745 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) LH89_01750 ENOG4108PU9 oligogalacturonate-specific porin LH89_01755 ENOG4105EIF outer membrane protein W LH89_01760 ENOG4108S3I UPF0259 membrane protein LH89_01765 ENOG4107835 probably involved in intracellular septation (By similarity) LH89_01770 ENOG4105NAU thioesterase Superfamily protein LH89_01775 ENOG410822N TonB family LH89_01780 ENOG4105K9H YciI-like protein LH89_01785 ENOG4105C8Q Methyl-accepting chemotaxis LH89_01795 ENOG4105CQX Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity) LH89_01805 ENOG4108JQ7 (ABC) transporter LH89_01810 ENOG4105C3U ABC transporter LH89_01815 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component LH89_01820 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component LH89_01825 ENOG4107QSI ABC, transporter LH89_01835 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein LH89_01845 ENOG4108EKI Dehydrogenase LH89_01850 ENOG4107104 thymidine kinase LH89_01860 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase LH89_01865 ENOG4105I93 response regulator LH89_01870 ENOG4105D78 K07001 NTE family protein LH89_01875 ENOG4105K5B UPF0225 protein LH89_01880 ENOG4105CIY formyltetrahydrofolate deformylase LH89_01890 ENOG4105EN6 Membrane LH89_01895 ENOG4105CGK Exodeoxyribonuclease III LH89_01900 ENOG4105MTM Protein of unknown function (DUF1496) LH89_01905 ENOG4108IYH Dna topoisomerase LH89_01910 ENOG41069NU Nitroreductase LH89_01915 ENOG4105D07 Signal peptide peptidase, SppA LH89_01920 ENOG4105HDK L-asparaginase LH89_01925 ENOG4108RWI nicotinamidase LH89_01930 ENOG4105VUT cytoplasmic protein LH89_01935 ENOG4105E0X reductase LH89_01945 ENOG4105DSB aldose 1-epimerase LH89_01950 ENOG4105CV8 reductase LH89_01955 ENOG4105GNX MltA-interacting MipA family protein LH89_01960 ENOG4105CYN Serine protein kinase LH89_01965 ENOG4106AKX UPF0229 protein LH89_01995 ENOG4105Y3U Transglycosylase-associated protein LH89_02005 ENOG4105NKT exported protein LH89_02030 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family LH89_02050 ENOG41090A1 ferritin LH89_02055 ENOG4108PNC copper resistance LH89_02065 ENOG4105MPK DNA polymerase III subunit theta LH89_02075 ENOG4105CUG Oligopeptidase b LH89_02080 ENOG4108HH9 Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR LH89_02085 ENOG4108UHU Aldolase LH89_02090 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase LH89_02095 ENOG4106KNT transcriptional regulator LH89_02100 ENOG4105CA9 Pyruvate kinase LH89_02110 ENOG4105CMM transposase LH89_02125 ENOG4105NWR lipid A biosynthesis (Kdo)2-(Lauroyl)-lipid IVA acyltransferase LH89_02130 ENOG4105DR5 peptidase LH89_02135 ENOG4105NXV High-affinity zinc uptake system protein LH89_02140 ENOG4105FDK ABC transporter LH89_02145 ENOG4105FAV ABC, transporter LH89_02150 ENOG4105CKJ The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity) LH89_02155 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) LH89_02165 ENOG4105CV1 Transketolase (EC 2.2.1.1) LH89_02170 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) LH89_02175 ENOG4108YZG isomerase LH89_02180 ENOG4105VI0 Pts system, glucitol sorbitol-specific LH89_02185 ENOG4105CAX The 2-keto-3-deoxygluconate permease transports the degraded pectin products into the bacterial cell, where they serve as carbon and energy sources. This is a hydrogen coupled transport system (By similarity) LH89_02190 ENOG4105G63 Type III effector Hrp-dependent LH89_02205 ENOG4105DKT Transcriptional regulator LH89_02215 ENOG4105CDY transcriptional regulatory protein LH89_02220 ENOG4108TIT dATP pyrophosphohydrolase LH89_02225 ENOG4105C9M aspartyl-trna synthetase LH89_02230 ENOG41081XQ Conserved Protein LH89_02235 ENOG4105WJG Glutathione LH89_02240 ENOG4105DA6 Catalyzes the conversion of 5-methoxyuridine (mo5U) to uridine-5-oxyacetic acid (cmo5U) at position 34 in tRNA. May also participate in the methylation of uridine-5-oxyacetic acid (cmo5U) to uridine-5-oxyacetic acid methyl ester (mcmo5U) (By similarity) LH89_02245 ENOG4105PFA Catalyzes the conversion of 5-hydroxyuridine (ho5U) to 5-methoxyuridine (mo5U) at position 34 in tRNA (By similarity) LH89_02255 ENOG4106N3A copper homeostasis protein cutc LH89_02260 ENOG4106ZCM YecM protein LH89_02265 ENOG4105C75 arginyL-tRNA synthetase LH89_02360 ENOG4105CJR Integral membrane protein (MviN LH89_02365 ENOG4105EP9 oxidoreductase LH89_02370 ENOG4108YXG UPF0502 protein LH89_02375 ENOG4105D9U N-acetyltransferase LH89_02380 ENOG4105EV4 Multidrug resistance protein mdtH LH89_02385 ENOG4105E9S glutaredoxin 2 LH89_02390 ENOG4105F3T (LipO)protein LH89_02395 ENOG4107XHZ cytoplasmic chaperone TorD family protein LH89_02400 ENOG4107SSZ Phosphatase LH89_02425 ENOG4105ES4 Nitrilase LH89_02435 ENOG4107EDW L-fucose operon activator LH89_02440 ENOG4107VIJ nudix hydrolase LH89_02445 ENOG4108K3A Glutathione S-transferase LH89_02455 ENOG4105P8F nudix hydrolase LH89_02460 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase LH89_02465 ENOG4105KVH Transcriptional regulator LH89_02470 ENOG4105E3B Multicopper oxidase LH89_02475 ENOG4105CR4 methylisocitrate lyase LH89_02490 ENOG4105EXC Acyl-transferase LH89_02515 ENOG4105DUC Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division (By similarity) LH89_02520 ENOG4105DAH Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF (By similarity) LH89_02525 ENOG4105GHU Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity (By similarity) LH89_02530 ENOG4106371 Methyltransferase LH89_02535 ENOG4107S90 membrAne LH89_02540 ENOG4107VR7 transferase activity, transferring phosphorus-containing groups LH89_02550 ENOG4105CET Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity) LH89_02555 ENOG4105W49 UPF0434 protein LH89_02560 ENOG4105CHD Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity) LH89_02565 ENOG4105BZ1 (ABC) transporter LH89_02570 ENOG4108EQH DNA internalization-related competence protein ComEC Rec2 LH89_02580 ENOG41090HJ UPF0265 protein LH89_02585 ENOG4105CJB Exodeoxyribonuclease I LH89_02595 ENOG4105CUB amino acid LH89_02600 ENOG4108T7K Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Increasing levels of c-di-GMP lead to decreased motility (By similarity) LH89_02605 ENOG4108K6F triphosphoribosyl-dephospho-CoA synthase LH89_02610 ENOG4108K6F triphosphoribosyl-dephospho-CoA synthase LH89_02615 ENOG4105CHY citrate lyase, alpha LH89_02620 ENOG4105CI0 Citrate lyase LH89_02625 ENOG4105XGS Covalent carrier of the coenzyme of citrate lyase (By similarity) LH89_02630 ENOG4105DUA (citrate (pro-3S)-lyase ligase LH89_02635 ENOG4105ERH Fumarylacetoacetate hydrolase LH89_02640 ENOG4105D2K citrate carrier protein LH89_02645 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism LH89_02650 ENOG4106YYS transcriptional regulatory protein LH89_02655 ENOG4105C8Q Methyl-accepting chemotaxis LH89_02660 ENOG4108535 NAD dependent epimerase/dehydratase family LH89_02665 ENOG4105E21 Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity (By similarity) LH89_02670 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) LH89_02675 ENOG4105CIH Imidazole acetol-phosphate transaminase LH89_02680 ENOG4105ECC imidazole-glycerol-phosphate dehydratase LH89_02685 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) LH89_02690 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase LH89_02695 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) LH89_02700 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase LH89_02715 ENOG41080YA This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity) LH89_02720 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) LH89_02725 ENOG4105CAT Cytidine monophosphate kinase LH89_02730 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase LH89_02735 ENOG4107QM1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) LH89_02740 ENOG4105DDY UPF0142 protein ycaO LH89_02745 ENOG4105TMB Formate nitrite transporter LH89_02750 ENOG4105C6N Formate acetyltransferase LH89_02755 ENOG4105F1A Pyruvate formate-lyase LH89_02765 ENOG4108ISG Major Facilitator LH89_02770 ENOG4105EJC lysr family transcriptional regulator LH89_02790 ENOG4108NEM leader-binding protein dmsD LH89_02795 ENOG4105CGR Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity) LH89_02800 ENOG4105D1H recombination factor protein RarA LH89_02805 ENOG4107Y7W Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane) (By similarity) LH89_02810 ENOG4105CNU cell division protein FtsK LH89_02815 ENOG4105EW9 transcriptional regulator AsnC family LH89_02820 ENOG4105C3M thioredoxin reductase LH89_02825 ENOG4108JJ9 ABC, transporter LH89_02830 ENOG4108JJ8 (ABC) transporter LH89_02835 ENOG4108R4Z Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine (By similarity) LH89_02840 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) LH89_02845 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit LH89_02850 ENOG4105KAE Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation (By similarity) LH89_02855 ENOG4105VEQ Cold shock protein LH89_02860 ENOG4105CPB ATP-dependent endonuclease of the OLD family LH89_02865 ENOG4105EJ7 Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity) LH89_02870 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) LH89_02875 ENOG4105CGD Nad-dependent epimerase dehydratase LH89_02880 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase LH89_02885 ENOG4105K8R UPF0145 protein LH89_02890 ENOG4105E5Z arginine transporter ATP-binding subunit LH89_02900 ENOG4105GBT ABC transporter LH89_02905 ENOG4105DMR ABC, transporter LH89_02910 ENOG4106TNF Periplasmic binding protein LH89_02920 ENOG4107SFS Catalyzes the formation of 5-methyl-uridine at position 747 (m5U747) in 23S rRNA (By similarity) LH89_02925 ENOG4105RBQ inner membrane protein ybjO LH89_02930 ENOG4105D38 putrescine abc transporter LH89_02935 ENOG4105F38 ABC transporter, permease LH89_02940 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) LH89_02945 ENOG4107RUE extracellular solute-binding protein family 1 LH89_02950 ENOG4108RMJ sensory transduction regulator LH89_02955 ENOG4105D9I Responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 (By similarity) LH89_02960 ENOG4108DBC nitroreductase LH89_02965 ENOG41090BQ Glutaredoxin LH89_02970 ENOG4105GWF inner membrane protein YbjM LH89_02975 ENOG4105D0C transport protein LH89_02980 ENOG4107FB0 transcriptional regulator DeoR family LH89_02985 ENOG4105DZ1 carboxypeptidase LH89_02990 ENOG4108YI3 3-hydroxyacyl-CoA-acyl carrier protein transferase LH89_02995 ENOG4108UMI ABC transporter, permease LH89_03000 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) LH89_03005 ENOG4105D01 (LipO)protein LH89_03010 ENOG4108TGY Glutathione S-transferase LH89_03015 ENOG4105D8V Glucose sorbosone dehydrogenase LH89_03020 ENOG4105CBM Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12 (By similarity) LH89_03025 ENOG4107GZ4 SanA protein LH89_03030 ENOG4105DHF Membrane LH89_03035 ENOG4105EUJ GTP cyclohydrolase i LH89_03040 ENOG4105C8Q Methyl-accepting chemotaxis LH89_03045 ENOG4105C8Q Methyl-accepting chemotaxis LH89_03050 ENOG4105C8Q Methyl-accepting chemotaxis LH89_03055 ENOG4105C8Q Methyl-accepting chemotaxis LH89_03065 ENOG4105C8Q Methyl-accepting chemotaxis LH89_03075 ENOG4105EGI Transcriptional regulator LH89_03100 ENOG4107SCQ Iron-containing alcohol dehydrogenase LH89_03105 ENOG4105C2J ABC transporter LH89_03110 ENOG4105CNN ABC, transporter LH89_03120 ENOG4105C7S Dehydrogenase LH89_03135 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) LH89_03145 ENOG4108IQI permease LH89_03150 ENOG4105DUM transcriptional regulator, lysR family LH89_03155 ENOG4105HMI Membrane LH89_03160 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) LH89_03170 ENOG4105DM4 PTS System LH89_03175 ENOG4105DE4 1-phosphofructokinase LH89_03180 ENOG4105DTZ bifunctional PTS system fructose-specific transporter subunit IIA HPr protein LH89_03190 ENOG4105KRS Proteinase inhibitor LH89_03195 ENOG4105FUQ Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) LH89_03200 ENOG4105CKI cobalamin synthesis protein LH89_03205 ENOG41076MN Phosphoesterase, PA-phosphatase related LH89_03210 ENOG4107TT5 NLP P60 protein LH89_03215 ENOG4105E43 Extracellular solute-binding protein, family 5 LH89_03220 ENOG4108I5X binding-protein-dependent transport systems inner membrane Component LH89_03225 ENOG4108IYQ Binding-protein-dependent transport systems inner membrane component LH89_03230 ENOG4108JQ5 ABC transporter LH89_03235 ENOG4105HG6 LH89_03240 ENOG4105C2C drug resistance transporter, Bcr CflA LH89_03245 ENOG4105I08 Pseudouridine synthase LH89_03255 ENOG4105VVZ metal-binding protein LH89_03260 ENOG4105CFI type iii restriction protein res subunit LH89_03270 ENOG4105KW6 This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity) LH89_03275 ENOG4105FCD Major Facilitator LH89_03280 ENOG4105DY9 regulatoR LH89_03285 ENOG4108HRK Histidine kinase LH89_03290 ENOG4106V8H Nucleoid-associated protein LH89_03295 ENOG4105PAN UPF0352 protein LH89_03300 ENOG4105E68 Sulfatase LH89_03345 ENOG4105K89 arsenate reductase LH89_03360 ENOG410620I Diguanylate cyclase LH89_03390 ENOG4105C3U ABC transporter LH89_03395 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component LH89_03420 ENOG4105RA2 Membrane LH89_03425 ENOG4105NBR Pectinesterase LH89_03450 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) LH89_03455 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) LH89_03470 ENOG4108ZNX Heat shock protein LH89_03490 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase LH89_03500 ENOG4105E7W lamb ycsf family protein LH89_03510 ENOG4105DJ2 Major Facilitator Superfamily LH89_03515 ENOG4108ZT1 Transcriptional regulator LH89_03520 ENOG4108T1M outer membrane protein x LH89_03530 ENOG4105DPV During stationary phase, binds the chromosome non- specifically, forming a highly ordered and stable dps-DNA co- crystal within which chromosomal DNA is condensed and protected from diverse damages. It protects DNA from oxidative damage by sequestering intracellular Fe(2 ) ion and storing it in the form of Fe(3 ) oxyhydroxide mineral, which can be released after reduction. One hydrogen peroxide oxidizes two Fe(2 ) ions, which prevents hydroxyl radical production by the Fenton reaction LH89_03535 ENOG4107R0W ABC transporter LH89_03540 ENOG4105E5Q amino acid AbC transporter LH89_03545 ENOG4105CDA abc transporter atp-binding protein LH89_03560 ENOG4105JQN Transcriptional regulator LH89_03575 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase LH89_03590 ENOG4108MTB glycosyl transferase family LH89_03600 ENOG4105DVT helicase LH89_03610 ENOG4107QK4 glycoside hydrolase, family 3 domain protein LH89_03615 ENOG4105BZ8 glutamate synthase LH89_03620 ENOG4105D95 Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity) LH89_03625 ENOG4108JPW Aminotransferase LH89_03635 ENOG4107MKT Stringent starvation protein a LH89_03640 ENOG41061WM D-Alanyl-D-Alanine LH89_03645 ENOG4105WPN DNA integration recombination invertion protein LH89_03655 ENOG4105FBT Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity) LH89_03660 ENOG4105DEF Extracellular solute-binding protein, family 5 LH89_03665 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) LH89_03675 ENOG4108Z7R Chaperone CsaA LH89_03690 ENOG4107T6V glycerophosphoryl diester phosphodiesterase LH89_03695 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component LH89_03705 ENOG4107H6U ABC transporter LH89_03710 ENOG4105C3U ABC transporter LH89_03725 ENOG4108Q5Y Membrane LH89_03730 ENOG4105C1J atp-dependent rna helicase LH89_03735 ENOG4105D0S secretion protein (HlyD LH89_03740 ENOG4105CJ1 ABC, transporter LH89_03745 ENOG4107QWP ABC-2 type transporter LH89_03750 ENOG4107QWP ABC-2 type transporter LH89_03755 ENOG4105X23 Endonuclease Exonuclease phosphatase LH89_03760 ENOG4105DZQ phospholipase D Transphosphatidylase LH89_03765 ENOG4105HFZ Membrane LH89_03785 ENOG4108ZAF Molybdopterin LH89_03790 ENOG4105M00 molybdopterin converting factor, subunit 1 LH89_03800 ENOG4108RIR Molybdenum cofactor biosynthesis protein LH89_03805 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) LH89_03815 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii LH89_03820 ENOG4105C4M (Ubiquinol oxidase) subunit I LH89_03830 ENOG4105CHW UPF0052 protein LH89_03840 ENOG4105CCW damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity) LH89_03855 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) LH89_03860 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) LH89_03865 ENOG4105CZF Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism (By similarity) LH89_03880 ENOG4105VAW lrga family LH89_03885 ENOG41067MG lrgb family LH89_03895 ENOG4107T42 This enzyme scavenge exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis (By similarity) LH89_03900 ENOG4107R1I NAD-dependent malic enzyme LH89_03905 ENOG4105CVM Molybdenum cofactor synthesis domain protein LH89_03910 ENOG4105D06 uba thif-type nad fad binding protein LH89_03920 ENOG4107TVC Glycosyl transferase, family 2 LH89_03930 ENOG4105VPI YqaE family transport protein LH89_03940 ENOG4105EXZ Involved in the regulation of ptsG expression by binding and inactivating Mlc (By similarity) LH89_03955 ENOG4105CF7 AraC family transcriptional regulator LH89_03960 ENOG4107QW4 alcohol dehydrogenase LH89_03965 ENOG4105DSE periplasmic solute binding protein LH89_03970 ENOG4105DIK (ABC) transporter LH89_03975 ENOG4105CC5 ABC transporter LH89_03980 ENOG4105CC5 ABC transporter LH89_03985 ENOG4108K70 Transcriptional regulator LH89_03990 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase LH89_03995 ENOG4105PSI phosphoribosyl-dephospho-CoA transferase LH89_04000 ENOG4107TT2 Auxin Efflux Carrier LH89_04035 ENOG4107R88 Chemotaxis protein (CheV) LH89_04050 ENOG4105WWK YheO domain protein LH89_04065 ENOG4105CFQ glutamine synthetase LH89_04085 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component LH89_04090 ENOG4105DU0 nucleoside hydrolase LH89_04095 ENOG4105DU0 nucleoside hydrolase LH89_04100 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) LH89_04105 ENOG4105DEF Extracellular solute-binding protein, family 5 LH89_04115 ENOG4105EAF CDP-diacylglycerol pyrophosphatase (EC 3.6.1.26) LH89_04130 ENOG4105DG7 nitrate ABC transporter LH89_04155 ENOG4108UMI ABC transporter, permease LH89_04165 ENOG4105D01 (LipO)protein LH89_04175 ENOG4105G4C Periplasmic ligand-binding sensor protein LH89_04190 ENOG4105EKC LH89_04205 ENOG4105WQ5 TonB family LH89_04215 ENOG4105SG9 biopolymer transport protein, ExbD LH89_04220 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component LH89_04225 ENOG4105BZU Histidine kinase LH89_04240 ENOG4105BZS acriflavin resistance protein LH89_04260 ENOG4108KHN disulfide isomerase, thiol-disulfide oxidase LH89_04285 ENOG4105U0F oligosaccharide H symporter, major facilitator superfamily (MFS) LH89_04300 ENOG4108MG3 formate dehydrogenase LH89_04305 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein LH89_04310 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) LH89_04320 ENOG4105PF0 Antitoxin component of a toxin-antitoxin (TA) module. Functions as an mRNA interferase antitoxin LH89_04325 ENOG4105JSC dimethylmenaquinone methyltransferase LH89_04330 ENOG4105E0A ABC, transporter LH89_04335 ENOG4108IHU transport system permease protein LH89_04340 ENOG4105DQ5 transport system permease protein LH89_04345 ENOG4108MES Periplasmic binding protein LH89_04350 ENOG4105DJU Siderophore biosynthesis protein LH89_04360 ENOG4105DUU IucA IucC family protein LH89_04365 ENOG4105C0R drug resistance transporter emrb qaca subfamily LH89_04370 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) LH89_04385 ENOG4108JPW Aminotransferase LH89_04405 ENOG4105EHI Phosphonate ABC transporter, periplasmic LH89_04415 ENOG4105CBN LysR family transcriptional regulator LH89_04425 ENOG4107SA6 carbon-phosphorus lyase complex accessory protein LH89_04430 ENOG4105MFQ Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP) (By similarity) LH89_04435 ENOG4105FD8 phosphonate metabolism protein PhnM LH89_04440 ENOG4105HRV phosphonate c-p lyase system protein phnl LH89_04445 ENOG4105ENV phosphonate C-P lyase system protein PhnK LH89_04450 ENOG4105FT8 Phosphonate metabolism LH89_04455 ENOG4105EKV Phosphonate metabolism protein LH89_04460 ENOG4105KZ6 phosphonate C-P lyase system protein PhnH LH89_04465 ENOG4105KQZ Phosphonate C-P lyase system protein PhnG LH89_04470 ENOG4107RJJ Transcriptional regulator LH89_04495 ENOG4105C8Y Acetylornithine aminotransferase LH89_04500 ENOG4105C26 Dehydrogenase LH89_04505 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family LH89_04515 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter LH89_04525 ENOG4105K6H D-cysteine desulfhydrase LH89_04530 ENOG4105DG4 malate L-lactate dehydrogenase LH89_04545 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component LH89_04550 ENOG4107SCQ Iron-containing alcohol dehydrogenase LH89_04560 ENOG4108SHQ Glutathione S-transferase LH89_04565 ENOG4105CYM Glutathione S-transferase LH89_04575 ENOG4107DB1 DUF218 domain LH89_04580 ENOG4108RS6 transposase LH89_04585 ENOG4105CK2 sodium dicarboxylate symporter LH89_04590 ENOG4107R11 Transcriptional regulator LH89_04595 ENOG4105DXC membrane LH89_04605 ENOG4105ECQ AraC Family Transcriptional Regulator LH89_04615 ENOG4108MFN small subunit of hydrogenase-3, iron-sulfur protein (part of formate hydrogenlyase (FHL) complex) LH89_04620 ENOG4108JPZ Monovalent cation H antiporter subunit D LH89_04625 ENOG4107TDF Formate hydrogenlyase subunit 4 LH89_04630 ENOG4105D65 subunit l LH89_04635 ENOG4107WQX hydrogenase 4 membrane subunit LH89_04640 ENOG4108JPZ Monovalent cation H antiporter subunit D LH89_04645 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) LH89_04655 ENOG4105C47 NADH ubiquinone oxidoreductase 20 kda subunit LH89_04660 ENOG4105I6X formate hydrogenlyase maturation LH89_04665 ENOG4108MG9 hydrogenase 3 maturation protease LH89_04680 ENOG4108RC0 Electron transport protein LH89_04685 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) LH89_04690 ENOG4108JUA Transcriptional regulator LH89_04695 ENOG4105CK2 sodium dicarboxylate symporter LH89_04700 ENOG4107YNJ LysR family Transcriptional regulator LH89_04710 ENOG4105ETE Transcriptional regulator (LacI family LH89_04715 ENOG4105CNT hydrolase family 2 LH89_04730 ENOG4105DRP amino acid AbC transporter LH89_04735 ENOG4108HW4 amino acid AbC transporter LH89_04755 ENOG4105CHM Aminotransferase LH89_04760 ENOG4105E7W lamb ycsf family protein LH89_04765 ENOG4107R7A Allophanate hydrolase subunit 2 LH89_04775 ENOG4106PMH Extracellular solute-binding protein family 3 LH89_04780 ENOG4105DFI Membrane LH89_04785 ENOG4105C2C drug resistance transporter, Bcr CflA LH89_04790 ENOG4105YP6 Domain of unknown function (DUF1869) LH89_04800 ENOG4105RI1 glycoprotein receptor LH89_04805 ENOG4107RA9 decarboxylase LH89_04815 ENOG4105C0R drug resistance transporter emrb qaca subfamily LH89_04820 ENOG4105CW7 secretion protein, HlyD family LH89_04825 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes LH89_04830 ENOG4108S9F abc transporter, atp-binding protein LH89_04835 ENOG4108RZA ABC transporter LH89_04840 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component LH89_04845 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component LH89_04850 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein LH89_04855 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) LH89_04865 ENOG4105C1X Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity (By similarity) LH89_04875 ENOG4105KT7 mgtC SapB transporter LH89_04880 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component LH89_04890 ENOG4105BZU Histidine kinase LH89_04895 ENOG4108ZXC Two component transcriptional regulator, luxr family LH89_04905 ENOG41067MG lrgb family LH89_04915 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase LH89_04920 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) LH89_04925 ENOG4107QR9 Iron-sulfur cluster binding protein LH89_04930 ENOG4108ZZK Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source (By similarity) LH89_04945 ENOG4105C5H ABC transporter LH89_04950 ENOG4108VCT Sulfite exporter TauE/SafE LH89_04955 ENOG4109025 Glyoxalase Bleomycin resistance protein (Dioxygenase LH89_04975 ENOG4105CN8 Transcriptional regulator LH89_04985 ENOG4105E3W Two component transcriptional regulator (Winged helix family LH89_04990 ENOG4105C1P efflux transporter, rnd family, mfp subunit LH89_04995 ENOG4105BZS acriflavin resistance protein LH89_05045 ENOG4105CHR reductase LH89_05050 ENOG4107QKG PfaD family LH89_05055 ENOG4108RKI Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl- ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)- decenoyl-ACP. Can catalyze the dehydratase reaction for beta- hydroxyacyl-ACPs with saturated chain lengths up to 16 0, being most active on intermediate chain length (By similarity) LH89_05080 ENOG4105ENT Efflux transporter rnd family, mfp subunit LH89_05090 ENOG4105CSH Transporter LH89_05095 ENOG4105XDF Protein of unknown function (DUF1272) LH89_05125 ENOG4107S8C mandelate racemase muconate lactonizing LH89_05130 ENOG4105F0I Aminotransferase LH89_05180 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit LH89_05230 ENOG4105CH2 amidohydrolase LH89_05260 ENOG4105CNA YD repeat protein LH89_05315 ENOG4105CS6 Rhs element vgr protein LH89_05320 ENOG4108WC9 type VI secretion system effector, hcp1 family LH89_05330 ENOG4105F7F Chaperone LH89_05335 ENOG4105QFC Hsc56 co-chaperone of HscC LH89_05345 ENOG4105FYV Amp nucleosidase LH89_05360 ENOG4105C3U ABC transporter LH89_05365 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component LH89_05375 ENOG4105VJY transcriptional regulator LH89_05390 ENOG4108RMU ferritin dps family protein LH89_05395 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) LH89_05405 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) LH89_05410 ENOG4105EHG Permease protein LH89_05415 ENOG4107R4I Periplasmic binding protein LH89_05420 ENOG4106QJH hemin transport protein LH89_05440 ENOG4108MJ5 VirK protein LH89_05445 ENOG4105CHR reductase LH89_05460 ENOG4105BZU Histidine kinase LH89_05480 ENOG4105E3R (LipO)protein LH89_05485 ENOG4108Q9C Periplasmic Protein LH89_05490 ENOG4108MDC (LipO)protein LH89_05495 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) LH89_05505 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase LH89_05525 ENOG4105CJT Mannose-1-phosphate guanylyltransferase LH89_05535 ENOG4105ER6 polysaccharide biosynthesis protein LH89_05540 ENOG4108SHN Glycosyl transferase, family 2 LH89_05550 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase LH89_05560 ENOG4105C1B dTDP-glucose 4-6-dehydratase LH89_05570 ENOG4108KBE Glycosyl transferase, family 2 LH89_05575 ENOG4108TJN glycosyl transferase group 1 LH89_05595 ENOG4105D75 Capsular exopolysaccharide family LH89_05600 ENOG4107ZF2 Phosphatase LH89_05605 ENOG4105DAY polysaccharide export protein LH89_05615 ENOG4105EE5 Membrane protein terC LH89_05620 ENOG4108GAE asmA family LH89_05625 ENOG4105DHP deoxycytidine triphosphate deaminase LH89_05630 ENOG4105DBI uridine monophosphokinase LH89_05635 ENOG4105D1F ATP-binding protein LH89_05640 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) LH89_05660 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) LH89_05665 ENOG4108K4B hydrolase LH89_05670 ENOG4105CGB Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system (By similarity) LH89_05675 ENOG4105E0C molybdate abc transporter LH89_05680 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein LH89_05685 ENOG410680R Protein of unknown function (DUF2592) LH89_05690 ENOG4105F4R Transcriptional regulator mode LH89_05695 ENOG4105DKW ABC transporter LH89_05700 ENOG4105CMR udp-glucose 4-epimerase LH89_05705 ENOG4105F0Z galactose-1-phosphate uridylyltransferase LH89_05715 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) LH89_05735 ENOG4105EP1 Efflux transporter rnd family, mfp subunit LH89_05740 ENOG4108IJF Heavy metal efflux pump, CzcA LH89_05745 ENOG4105DKJ Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) LH89_05750 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) LH89_05755 ENOG4105PGM cation diffusion facilitator family transporter LH89_05760 ENOG4106Z1T Nicotinamide Mononucleotide Transporter LH89_05765 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) LH89_05770 ENOG4108UQV Membrane LH89_05785 ENOG4105UFD tol-pal system protein YbgF LH89_05790 ENOG4105KCK Peptidoglycan-associated lipoprotein LH89_05795 ENOG4107R6Y Involved in the TonB-independent uptake of proteins (By similarity) LH89_05800 ENOG4108Z82 Cell envelope integrity inner membrane protein TolA LH89_05805 ENOG4105M8F Biopolymer transport protein exbD tolR LH89_05810 ENOG4105E02 MotA TolQ exbB proton channel LH89_05815 ENOG4107YD3 Thioesterase LH89_05820 ENOG4105KJB cyd operon protein YbgE LH89_05830 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii LH89_05835 ENOG4105C4M (Ubiquinol oxidase) subunit I LH89_05840 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha LH89_05845 ENOG4105CMV Succinyl-CoA synthetase subunit beta LH89_05850 ENOG4105C7S Dehydrogenase LH89_05855 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 LH89_05860 ENOG4105E33 succinate dehydrogenase LH89_05870 ENOG4105N1I succinate dehydrogenase, hydrophobic membrane anchor protein LH89_05875 ENOG4108UTY succinate dehydrogenase, cytochrome b556 subunit LH89_05880 ENOG4105BZN citrate synthase LH89_05885 ENOG4108S0J Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized pyrimidines, such as thymine glycol, 5,6-dihydrouracil and 5,6-dihydrothymine. Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'- phosphates (By similarity) LH89_05890 ENOG4105E7W lamb ycsf family protein LH89_05895 ENOG4107R7A Allophanate hydrolase subunit 2 LH89_05900 ENOG4105P4J Allophanate hydrolase, subunit 1 LH89_05905 ENOG4107QNR UPF0135 protein LH89_05910 ENOG4105CVP deoxyribo-dipyrimidine photolyase LH89_05915 ENOG4107SEY Conserved Protein LH89_05920 ENOG4105XIQ Protein of unknown function (DUF2517) LH89_05930 ENOG4105D9K One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) LH89_05935 ENOG4105C8X One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) LH89_05940 ENOG4108R80 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity) LH89_05945 ENOG4105C08 Histidine kinase LH89_05950 ENOG4105EEX Two component transcriptional regulator (Winged helix family LH89_05960 ENOG4107QIX Phosphoglucomutase (EC 5.4.2.2 LH89_05965 ENOG4107CDU Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated (By similarity) LH89_05970 ENOG4105EV9 Alpha Beta Hydrolase LH89_05975 ENOG4105NNH LexA regulated protein LH89_05980 ENOG4105C8Q Methyl-accepting chemotaxis LH89_05985 ENOG4105MHQ Low-potential electron donor to a number of redox enzymes (By similarity) LH89_05990 ENOG41090R7 Ferric uptake LH89_05995 ENOG4105CX6 glutaminyL-tRNA synthetase LH89_06000 ENOG4105CI1 PTS System LH89_06005 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) LH89_06010 ENOG4105CE4 GlcNAc 6-P deacetylase LH89_06015 ENOG4105E2R ROK family LH89_06020 ENOG4105CAQ asparagine synthetase LH89_06060 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family LH89_06065 ENOG4105CIW Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity) LH89_06070 ENOG4105C9A Phoh family LH89_06075 ENOG4105KGE Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity) LH89_06080 ENOG4108JU5 Magnesium and cobalt efflux protein LH89_06085 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) LH89_06090 ENOG4107RP9 extracellular solute-binding protein, family 3 LH89_06095 ENOG4105EAD ABC transporter LH89_06100 ENOG4105DRP amino acid AbC transporter LH89_06105 ENOG4105CDA abc transporter atp-binding protein LH89_06110 ENOG4107PAI alpha helical protein LH89_06115 ENOG4105C8T Leucyl-tRNA synthetase LH89_06120 ENOG4108U2H Rare lipoprotein B LH89_06125 ENOG4105DJF DNA polymerase III, delta' subunit LH89_06130 ENOG4108Z1W Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity) LH89_06135 ENOG4105KEM Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) LH89_06140 ENOG4108UXA Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity) LH89_06145 ENOG4105CJN penicillin-binding protein LH89_06150 ENOG4105CNI cell division protein FtsW LH89_06155 ENOG4105K6T rare lipoprotein A LH89_06160 ENOG4105DZ1 carboxypeptidase LH89_06165 ENOG4108Z43 UPF0250 protein LH89_06170 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) LH89_06175 ENOG4105C0G Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity) LH89_06180 ENOG410607N Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatE shares overlapping functions with TatA (By similarity) LH89_06185 ENOG4107QPI nitrilase cyanide hydratase and apolipoprotein n-acyltransferase LH89_06190 ENOG4107Z6W Protein CrcB homolog LH89_06195 ENOG4105VEQ Cold shock protein LH89_06205 ENOG4105KUZ arsenate reductase LH89_06210 ENOG4105C9Y Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity) LH89_06225 ENOG4106KED esterase YpfH LH89_06230 ENOG4105E0I Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP) (By similarity) LH89_06235 ENOG4108VMM UPF0756 membrane protein LH89_06240 ENOG4105C8V SAICAR synthetase LH89_06245 ENOG4107EG0 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) LH89_06255 ENOG4105RH4 Glycine cleavage system transcriptional repressor LH89_06260 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen LH89_06270 ENOG4105ERG peptidase m48, ste24p LH89_06275 ENOG4105K89 arsenate reductase LH89_06280 ENOG4108KZ1 Mediates the interaction of DNA replication inititator protein DnaA with DNA polymerase subunit beta sliding clamp (dnaN). Stimulates hydrolysis of ATP-DnaA to ADP-DnaA, rendering DnaA inactive for reinititation, a process called regulatory inhibition of DnaA or RIDA (By similarity) LH89_06285 ENOG4105C2W permease LH89_06290 ENOG4105CZ5 Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity) LH89_06295 ENOG4105CXB phosphoribosylaminoimidazole synthetase LH89_06300 ENOG4108V3E phosphoribosylglycinamide formyltransferase LH89_06305 ENOG41060NJ transcriptional regulator LH89_06315 ENOG4105C2J ABC transporter LH89_06320 ENOG4107SDZ Galactoside transport system permease protein mglC LH89_06325 ENOG4105EAB amino acid AbC transporter LH89_06330 ENOG4105E5Q amino acid AbC transporter LH89_06335 ENOG4105S10 periplasmic binding protein LH89_06345 ENOG4108MK9 spermidine N(1)-acetyltransferase LH89_06350 ENOG4105CV6 ABC transporter, permease LH89_06355 ENOG4108I0Y (ABC) transporter LH89_06360 ENOG4108UJV acyl-CoA thioesterase i LH89_06365 ENOG4105E1F short-chain dehydrogenase reductase LH89_06370 ENOG4107QR8 Thioredoxin LH89_06380 ENOG4108UII YfaZ family LH89_06390 ENOG4105CEY Amp-dependent synthetase and ligase LH89_06395 ENOG4105DNI Converts SHCHC to OSB (By similarity) LH89_06400 ENOG4108IPT Naphthoate synthase LH89_06405 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) LH89_06410 ENOG4105C4A Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC) (By similarity) LH89_06415 ENOG4105E4F Isochorismate synthase LH89_06420 ENOG4106UW1 Major Facilitator superfamily LH89_06425 ENOG4105E3G Phosphotransfer intermediate protein in two-component regulatory system with RcsBC LH89_06430 ENOG41068CG regulatoR LH89_06435 ENOG4105BZU Histidine kinase LH89_06440 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) LH89_06445 ENOG4107RFD Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) LH89_06450 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) LH89_06455 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) LH89_06460 ENOG4105XPH Ferredoxin LH89_06465 ENOG4107QX8 SPFH domain, Band 7 family protein LH89_06470 ENOG4105G5H Membrane LH89_06475 ENOG4108Z6Z Transcriptional regulator LH89_06480 ENOG4105C59 p-type ATPase LH89_06485 ENOG4105MBR gumn family LH89_06490 ENOG4108Z66 YbaK ebsC protein LH89_06500 ENOG4105C8Q Methyl-accepting chemotaxis LH89_06510 ENOG4105CGH 5'-nucleotidase LH89_06515 ENOG4105CKD glutathione-regulated potassium-efflux system protein LH89_06520 ENOG4105CFX Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) LH89_06525 ENOG4105CC8 Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity) LH89_06530 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) LH89_06535 ENOG4105F3K May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity) LH89_06540 ENOG4105KDX Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity) LH89_06545 ENOG4107QMP dna polymerase iii subunits gamma and tau LH89_06550 ENOG4109003 Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity) LH89_06555 ENOG4105WD1 Membrane LH89_06560 ENOG4105FR9 TRNA-(Ms 2 io 6 A)-hydroxylase LH89_06575 ENOG4105EGS Mechanosensitive ion channel LH89_06580 ENOG4108IG5 Transcriptional regulator LH89_06585 ENOG4105C1P efflux transporter, rnd family, mfp subunit LH89_06590 ENOG4105BZS acriflavin resistance protein LH89_06595 ENOG4105NRA 50s ribosomal protein l31 type b LH89_06600 ENOG4105YK5 50S ribosomal protein L36 LH89_06605 ENOG4108UKR Biofilm formation regulator YbaJ LH89_06610 ENOG4105KF5 hemolysin expression-modulating protein LH89_06615 ENOG41080UX Methyltransferase LH89_06620 ENOG4108MNP Glycoprotein polysaccharide metabolism LH89_06625 ENOG4105C29 acyl-CoA thioesterase LH89_06630 ENOG4105BZU Histidine kinase LH89_06635 ENOG4108YZA Nitrogen regulatory protein pii LH89_06640 ENOG4105BZ1 (ABC) transporter LH89_06645 ENOG4105BZ1 (ABC) transporter LH89_06650 ENOG4108XM1 transcriptional regulator AsnC family LH89_06660 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) LH89_06665 ENOG41083P1 competence protein ComEA helix-hairpin-helix repeat protein LH89_06670 ENOG4105EIN peptidylprolyl cis-trans isomerase LH89_06675 ENOG4105K70 DNA-binding protein LH89_06680 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) LH89_06685 ENOG4105CHN ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP (By similarity) LH89_06690 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) LH89_06695 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation LH89_06700 ENOG4105M85 Bola protein LH89_06705 ENOG4105IEY (LipO)protein LH89_06710 ENOG4105EYM Major Facilitator superfamily LH89_06715 ENOG4105E2S oxidase) subunit II LH89_06720 ENOG4105BZ9 Cytochrome C oxidase, subunit I LH89_06725 ENOG4105CCU oxidase (Subunit III) LH89_06730 ENOG41090KH cytochrome o ubiquinol oxidase (subunit iv) LH89_06735 ENOG4105F1R Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group (By similarity) LH89_06740 ENOG4107RDB Major Facilitator LH89_06755 ENOG4108VPT UPF0234 protein LH89_06760 ENOG4108JZF Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) LH89_06765 ENOG4107S0N DJ-1 family LH89_06770 ENOG4105D8I Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity) LH89_06775 ENOG41067QG Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) LH89_06785 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) LH89_06790 ENOG4108ZAI phosphatidylglycerophosphatase a LH89_06795 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) LH89_06800 ENOG4107YIM Involved in the transcription termination process (By similarity) LH89_06805 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) LH89_06810 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) LH89_06815 ENOG4108Z11 Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes (By similarity) LH89_06820 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic LH89_06825 ENOG4108KIC (LipO)protein LH89_06830 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) LH89_06835 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) LH89_06840 ENOG4105VIE preprotein translocase, subunit YajC LH89_06845 ENOG4105C6U Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity) LH89_06850 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) LH89_06855 ENOG4108ZYK Acyl carrier protein phosphodiesterase LH89_06860 ENOG4105D3R alkyl hydroperoxide reductase LH89_06865 ENOG4105C85 amino acid LH89_06870 ENOG4105CWM branched-chain amino acid transport system II carrier protein LH89_06885 ENOG4105BZU Histidine kinase LH89_06895 ENOG4107RH8 nuclease SbcCD subunit D LH89_06900 ENOG4105EYH Exonuclease LH89_06905 ENOG4105DKQ ROK family LH89_06910 ENOG4105DH7 May be involved in recombination (By similarity) LH89_06915 ENOG4105C8Q Methyl-accepting chemotaxis LH89_06920 ENOG4105NBK UPF0345 protein LH89_06935 ENOG4105IBP Cyclic peptide transporter LH89_06955 ENOG4105EMY transcriptional regulator LH89_06965 ENOG4105CSH Transporter LH89_06980 ENOG4105DUM transcriptional regulator, lysR family LH89_07005 ENOG4105BZU Histidine kinase LH89_07010 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA LH89_07025 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) LH89_07035 ENOG4105EJC lysr family transcriptional regulator LH89_07095 ENOG4105D9U N-acetyltransferase LH89_07105 ENOG4108V1U phospholipid-binding protein LH89_07120 ENOG4108TVJ Nitroreductase LH89_07150 ENOG4105KVH Transcriptional regulator LH89_07165 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) LH89_07170 ENOG4107EII Lipoprotein involved with copper homeostasis and adhesion LH89_07175 ENOG4108VWS Yaeq family LH89_07180 ENOG4105W1I UPF0253 protein LH89_07185 ENOG4105M1T rho-binding antiterminator LH89_07190 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) LH89_07195 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase LH89_07200 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) LH89_07205 ENOG4105C0B DNA polymerase III (alpha subunit) LH89_07210 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) LH89_07215 ENOG4105D0V Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) LH89_07220 ENOG4105DAF Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) LH89_07225 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) LH89_07230 ENOG4105D7M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) LH89_07235 ENOG4108RFI Molecular chaperone that interacts specifically with outer membrane proteins, thus maintaining the solubility of early folding intermediates during passage through the periplasm (By similarity) LH89_07240 ENOG4105E1Z Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane LH89_07245 ENOG4105DZP Membrane-associated zinc metalloprotease LH89_07250 ENOG4105KNE Phosphatidate cytidylyltransferase LH89_07255 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) LH89_07260 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) LH89_07265 ENOG4108VCV Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another (By similarity) LH89_07275 ENOG4105C41 Catalyzes the reversible phosphorylation of UMP to UDP (By similarity) LH89_07280 ENOG4105CU7 Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity) LH89_07285 ENOG4105CE9 30S ribosomal protein S2 LH89_07290 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) LH89_07295 ENOG4105E1P Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity) LH89_07300 ENOG4105DMJ Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity) LH89_07305 ENOG4108T8E UPF0325 protein LH89_07310 ENOG4105QDK Flavodoxin LH89_07315 ENOG4105DR9 pseudouridine synthase LH89_07320 ENOG4105DR9 pseudouridine synthase LH89_07325 ENOG4108T6E Interacts with the SecY protein in vivo. May bind preferentially to an uncomplexed state of SecY, thus functioning either as a chelating agent for excess SecY in the cell or as a regulatory factor that negatively controls the translocase function (By similarity) LH89_07330 ENOG4105EWT decarboxylase family LH89_07335 ENOG4105CIQ May have a role in processing of nucleic acids. It is probably not an exonuclease LH89_07340 ENOG4105EZ6 Catalyzes the 2'-O-methylation at nucleotide C2498 in 23S rRNA (By similarity) LH89_07345 ENOG4105M08 Membrane LH89_07350 ENOG4105ETT transcriptional Regulator, LysR family LH89_07355 ENOG4105M5B (LipO)protein LH89_07360 ENOG4105C9B Cysteine desulfurase LH89_07365 ENOG4105P9C Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity) LH89_07370 ENOG4105CUZ uba thif-type nad fad binding protein LH89_07375 ENOG4105KEG ribosomal-protein-alanine acetyltransferase LH89_07380 ENOG4108M3J Dehydrogenase LH89_07390 ENOG4108RTV Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol (By similarity) LH89_07395 ENOG4105CA3 membrane-bound lytic murein transglycosylase LH89_07410 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase LH89_07415 ENOG4108EKC n-acetylglutamate synthase LH89_07420 ENOG4107QXK peptidase LH89_07435 ENOG4105JCS prepilin peptidase dependent protein LH89_07440 ENOG4105IPU prepilin peptidase dependent protein A LH89_07445 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) LH89_07450 ENOG4105C3B Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity) LH89_07455 ENOG4108HRM phosphoenolpyruvate--protein phosphotransferase LH89_07460 ENOG4105EJF Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage (By similarity) LH89_07465 ENOG4105IRT Sequence-specific endonuclease that cleaves unmethylated GATC sequences. It is involved in DNA mismatch repair (By similarity) LH89_07470 ENOG4105EE5 Membrane protein terC LH89_07475 ENOG4105SUV lipoprotein YgdR LH89_07480 ENOG4105CPC Aldo Keto reductase LH89_07500 ENOG4105K33 Periplasmic Protein LH89_07505 ENOG41090ED Protein with unknown function (DUF469) LH89_07510 ENOG4105CZ1 Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA (By similarity) LH89_07515 ENOG4105CEN a g-specific adenine glycosylase LH89_07520 ENOG4105KMG Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes (By similarity) LH89_07525 ENOG4106S48 Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and or cell division LH89_07530 ENOG4105C85 amino acid LH89_07535 ENOG4105CXN decarboxylase LH89_07585 ENOG4105EMU Dehydrogenase LH89_07610 ENOG4105UQX Mate efflux family protein LH89_07615 ENOG4105CHR reductase LH89_07655 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) LH89_07665 ENOG4108EE5 Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) LH89_07670 ENOG4108S5C Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell (By similarity) LH89_07710 ENOG4105KVH Transcriptional regulator LH89_07720 ENOG4105BZS acriflavin resistance protein LH89_07730 ENOG4105BZU Histidine kinase LH89_07735 ENOG4105CK6 Two component transcriptional regulator (Winged helix family LH89_07765 ENOG4108MGI Transcriptional regulator LH89_07775 ENOG4108TEB UPF0114 protein LH89_07780 ENOG4108QEY Rhamnogalacturonate lyase LH89_07795 ENOG4107R1K Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) LH89_07800 ENOG4105EJC lysr family transcriptional regulator LH89_07805 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) LH89_07820 ENOG4108JE9 extracellular solute-binding protein family 1 LH89_07825 ENOG4105EQ7 Binding-protein-dependent transport systems, inner membrane component LH89_07835 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) LH89_07840 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) LH89_07845 ENOG4108M60 Transcriptional regulator LH89_07850 ENOG41061EV selenium-binding protein YdfZ LH89_07870 ENOG4105D3S 4Fe-4S Ferredoxin, iron-sulfur binding domain protein LH89_07875 ENOG4105DVI reductase, NrfD LH89_07880 ENOG4105C0R drug resistance transporter emrb qaca subfamily LH89_07885 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) LH89_07890 ENOG4107EFR Flavocytochrome c LH89_07895 ENOG4105CF1 Alkylated DNA repair protein LH89_07910 ENOG4105C5Q Transcriptional regulator LH89_07915 ENOG4107GFK fumarate LH89_07920 ENOG4108JUA Transcriptional regulator LH89_07925 ENOG4105CNW domain protein LH89_07930 ENOG4108EQM faD-dependent pyridine nucleotide-disulfide oxidoreductase LH89_07940 ENOG4105C66 Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate (By similarity) LH89_07945 ENOG4105W0Z cytoplasmic protein LH89_07950 ENOG4105DVH amino acid LH89_07955 ENOG4107NPY receptor for the septal ring structure, may anchor it to the inner-membrane (By similarity) LH89_07960 ENOG4105EXN Sulfate transport protein CysZ LH89_07965 ENOG4105C6T cysteine synthase LH89_07970 ENOG4105KZ7 phosphocarrier protein hpr LH89_07980 ENOG4105C5Y PTS System LH89_07985 ENOG4105E0F Histidine kinase LH89_07990 ENOG4105E3W Two component transcriptional regulator (Winged helix family LH89_07995 ENOG4105DJY efflux transporter, rnd family, mfp subunit LH89_08000 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) LH89_08005 ENOG4105C6T cysteine synthase LH89_08010 ENOG4105EZR dyp-type peroxidase family protein LH89_08035 ENOG4105E7K (LipO)protein LH89_08040 ENOG4105CQ0 ABC transporter LH89_08045 ENOG4107RAN Peptidase, M16 LH89_08050 ENOG4105PE1 Receptor LH89_08055 ENOG410822N TonB family LH89_08060 ENOG4108R6G acetyltransferase LH89_08065 ENOG4105DBS Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III (By similarity) LH89_08070 ENOG4108UPT UPF0178 protein LH89_08075 ENOG4105C6K Malic enzyme LH89_08080 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) LH89_08085 ENOG4107VIJ nudix hydrolase LH89_08090 ENOG4105C56 H( )-stimulated, divalent metal cation uptake system (By similarity) LH89_08095 ENOG4105K90 Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ LH89_08100 ENOG4105F91 Catalyzes the phosphorylation of NAD to NADP. Utilizes ATP and other nucleoside triphosphates as well as inorganic polyphosphate as a source of phosphorus (By similarity) LH89_08105 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) LH89_08110 ENOG4105YRI Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) LH89_08115 ENOG4105VDB UPF0125 protein LH89_08120 ENOG4108Z1B Cyclase dehydrase LH89_08125 ENOG4108UH4 Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity) LH89_08130 ENOG4105DFP Integrase LH89_08190 ENOG4105C42 Type I secretion membrane fusion protein (HlyD LH89_08195 ENOG4108JJA ABC, transporter LH89_08265 ENOG4106NZI LysR family Transcriptional regulator LH89_08270 ENOG4105HVQ Regulatory factor of maltose metabolism LH89_08285 ENOG4105C0D helicase LH89_08350 ENOG4105EQR Transposase IS116 IS110 IS902 LH89_08360 ENOG4105CMM transposase LH89_08370 ENOG4105E89 ABC transporter LH89_08375 ENOG4105ENX hydrolase LH89_08380 ENOG4107RTG Major Facilitator superfamily LH89_08385 ENOG4105EQ2 LysR family Transcriptional regulator LH89_08405 ENOG4105DTQ mandelate racemase muconate lactonizing LH89_08410 ENOG4105DJB Major Facilitator Superfamily LH89_08415 ENOG4108KAM Transcriptional regulator LH89_08420 ENOG4105CVE Lytic murein transglycosylase LH89_08430 ENOG4105DH8 myo-inositol catabolism LH89_08440 ENOG4105EDK PfkB domain protein LH89_08450 ENOG4105CNN ABC, transporter LH89_08460 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator LH89_08470 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) LH89_08485 ENOG4107SDU Methyl-accepting chemotaxis LH89_08495 ENOG4108S5C Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell (By similarity) LH89_08500 ENOG4108HRG Involved in the cleavage of the C1-C2 bond of 3D- (3,5 4)-trihydroxycyclohexane-1,2-dione (THcHDO) to yield 5-deoxy- glucuronate (5DG) (By similarity) LH89_08505 ENOG4105C26 Dehydrogenase LH89_08520 ENOG4105CV8 reductase LH89_08525 ENOG4105HEI LysR family (Transcriptional regulator LH89_08530 ENOG4105F27 Major Facilitator LH89_08555 ENOG4105CPF Cell wall formation (By similarity) LH89_08570 ENOG4105Y50 Virulence Protein LH89_08575 ENOG4105CT4 transporter LH89_08580 ENOG4105E4I Glycoside hydrolase family 28 LH89_08605 ENOG4105D95 Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity) LH89_08610 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein LH89_08615 ENOG4108US0 Transcription regulator that can specifically activate or repress expression of target genes (By similarity) LH89_08625 ENOG4105C0R drug resistance transporter emrb qaca subfamily LH89_08630 ENOG4105DEI Mannitol dehydrogenase LH89_08640 ENOG4105CT4 transporter LH89_08670 ENOG4108S3W Anti-feci sigma factor, fecr LH89_08680 ENOG4108JQ7 (ABC) transporter LH89_08690 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component LH89_08695 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component LH89_08700 ENOG4105DEF Extracellular solute-binding protein, family 5 LH89_08705 ENOG4105CXK mandelate racemase muconate lactonizing LH89_08710 ENOG4105E0K tonB-dependent siderophore receptor LH89_08725 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) LH89_08730 ENOG41062QD Membrane LH89_08735 ENOG4107QN1 sodium solute LH89_08740 ENOG4105EEQ Na H antiporter LH89_08745 ENOG4105C7N Xanthine uracil vitamin C permease LH89_08750 ENOG4105D1S lipid A biosynthesis LH89_08770 ENOG4105DRS transport system, permease LH89_08775 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) LH89_08780 ENOG4108IJ9 (ABC) transporter LH89_08790 ENOG4105D3Q Sugar transferase LH89_08805 ENOG4105KVH Transcriptional regulator LH89_08835 ENOG4105BZS acriflavin resistance protein LH89_08885 ENOG4105CRK lysyL-tRNA synthetase LH89_08890 ENOG4105CG1 Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity) LH89_08895 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) LH89_08900 ENOG4105T95 Thiol disulfide interChange protein LH89_08905 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) LH89_08910 ENOG4105CSH Transporter LH89_08915 ENOG41071R3 Low-potential electron donor to a number of redox enzymes (By similarity) LH89_08930 ENOG4106XY2 Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity) LH89_08935 ENOG4108UT2 hemolysin iii LH89_08945 ENOG410829K Lysine exporter protein (Lyse ygga) LH89_08950 ENOG4105CBI The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor LH89_08955 ENOG4105KE9 The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity) LH89_08960 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) LH89_08965 ENOG4105C0A alcohol dehydrogenase LH89_08970 ENOG4105C7K acetolactate synthase LH89_08985 ENOG4105YBH Protein of unknown function (DUF1435) LH89_09005 ENOG4105CBN LysR family transcriptional regulator LH89_09010 ENOG4105CPC Aldo Keto reductase LH89_09015 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) LH89_09020 ENOG4108WPU DNA polymerase III subunit psi LH89_09025 ENOG4105KEG ribosomal-protein-alanine acetyltransferase LH89_09030 ENOG4108SF5 RNA Polymerase LH89_09040 ENOG4105CNM Receptor LH89_09045 ENOG4105CQ0 ABC transporter LH89_09050 ENOG4105D3A purine nucleoside phosphorylase DeoD-type LH89_09055 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) LH89_09065 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) LH89_09080 ENOG4108YYD acetyltransferase LH89_09085 ENOG4105XPQ lipid carrier protein LH89_09090 ENOG4105CFP Peptidase U32 LH89_09095 ENOG4106RZ4 Peptidase U32 LH89_09100 ENOG4105DEN Luciferase family LH89_09105 ENOG4105C1J atp-dependent rna helicase LH89_09115 ENOG4105C62 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity) LH89_09120 ENOG4105K77 Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity) LH89_09125 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) LH89_09130 ENOG4105KG7 Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity) LH89_09135 ENOG4107QHU One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity) LH89_09140 ENOG4105CHV Transcription elongation factor NusA LH89_09165 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) LH89_09170 ENOG4105EEI dihydropteroate synthase LH89_09175 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) LH89_09180 ENOG4105F7M Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit (By similarity) LH89_09185 ENOG4105HBR Rna-binding protein LH89_09190 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) LH89_09195 ENOG4106HRJ d-alanyl-d-alanine carboxypeptidase LH89_09200 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control LH89_09205 ENOG4105QYV Membrane LH89_09210 ENOG4105K46 50S ribosomal protein l27 LH89_09215 ENOG4105KK9 This protein binds to 23S rRNA in the presence of protein L20 (By similarity) LH89_09220 ENOG4105EAH synthase LH89_09240 ENOG410682Y Regulates arginine biosynthesis genes (By similarity) LH89_09245 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) LH89_09250 ENOG4105VCC 30S ribosomal protein S21 LH89_09255 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) LH89_09260 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) LH89_09280 ENOG4105E1F short-chain dehydrogenase reductase LH89_09285 ENOG4108W6C Dehydrogenase LH89_09290 ENOG4105CPC Aldo Keto reductase LH89_09315 ENOG4105CJ2 (LipO)protein LH89_09320 ENOG4108SPG Periplasmic Protein LH89_09325 ENOG4105CXY transporter LH89_09330 ENOG4105CXY transporter LH89_09335 ENOG4105BZU Histidine kinase LH89_09340 ENOG4108KX4 response regulator LH89_09355 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) LH89_09360 ENOG4105DU1 integral membrane protein, terc LH89_09365 ENOG4105P66 Membrane LH89_09370 ENOG4105CTX dehydratase LH89_09375 ENOG4107QZW Altronate oxidoreductase LH89_09380 ENOG4105D2H Uronic isomerase LH89_09385 ENOG4105DPW Major facilitator superfamily MFS_1 LH89_09395 ENOG4106W5V Membrane LH89_09400 ENOG4105VD9 Modulates the activity of the EnvZ OmpR two-component regulatory system, probably by directly modulating EnvZ enzymatic activity and increasing stability of phosphorylated OmpR (By similarity) LH89_09405 ENOG4105NE1 Conserved Protein LH89_09410 ENOG41090KG Inner membrane protein YqjE LH89_09425 ENOG4108VBZ doxx family LH89_09430 ENOG4105CHF Glutathione S-transferase LH89_09435 ENOG4105CWB LysR family transcriptional Regulator LH89_09440 ENOG4108CNN domain protein LH89_09445 ENOG4105MYN Zinc uptake regulation protein LH89_09450 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) LH89_09455 ENOG41080IJ Diacylglycerol kinase LH89_09460 ENOG4105E55 glycerol-3-phosphate acyltransferase LH89_09465 ENOG4105C4G Synthesis of 3-octaprenyl-4-hydroxybenzoate (By similarity) LH89_09470 ENOG4105VEI Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4- hydroxybenzoate (4HB) for the ubiquinone pathway (By similarity) LH89_09475 ENOG4105CJ9 Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions (By similarity) LH89_09480 ENOG4105K5Y Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter (By similarity) LH89_09500 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter LH89_09505 ENOG4105VF7 tolerance protein LH89_09510 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) LH89_09515 ENOG4108SIC Transcriptional regulator LH89_09535 ENOG41068PY Colanic acid biosynthesis acetyltransferase wcaB LH89_09550 ENOG4107RA4 Glycosyl transferase (Group 1 LH89_09555 ENOG4107QPH glycogen) synthase LH89_09590 ENOG4105D3Q Sugar transferase LH89_09595 ENOG4105DIA mandelate racemase muconate lactonizing LH89_09600 ENOG4105ETE Transcriptional regulator (LacI family LH89_09605 ENOG4105W1Y Transcriptional regulator LH89_09620 ENOG4105RD7 BadF BadG BcrA BcrD LH89_09635 ENOG4108ZBR Gcn5-related n-acetyltransferase LH89_09645 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component LH89_09650 ENOG4105DRS transport system, permease LH89_09680 ENOG41061H0 Monooxygenase LH89_09705 ENOG4105VT2 5-hydroxyisourate hydrolase LH89_09710 ENOG4105EQK -acetyltransferase LH89_09720 ENOG4108JU3 Alkyl hydroperoxide reductase LH89_09725 ENOG4105D3R alkyl hydroperoxide reductase LH89_09730 ENOG4105EHG Permease protein LH89_09740 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) LH89_09750 ENOG4105CH2 amidohydrolase LH89_09770 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) LH89_09775 ENOG4105C8Q Methyl-accepting chemotaxis LH89_09780 ENOG4108VHC Short-chain dehydrogenase reductase Sdr LH89_09795 ENOG4105EYA deoxyribonuclease LH89_09810 ENOG4105K3G Periplasmic Protein LH89_09815 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) LH89_09830 ENOG4107R6G Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate (By similarity) LH89_09835 ENOG41062Z9 Membrane LH89_09840 ENOG4105EAC phosphoserine phosphatase LH89_09845 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) LH89_09850 ENOG4107VZS Nicotinamide-nucleotide adenylyltransferase LH89_09855 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase LH89_09860 ENOG4107YUN Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division (By similarity) LH89_09870 ENOG4107RAQ aminopeptidase LH89_09875 ENOG4105D0A hydroxylase LH89_09880 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family LH89_09895 ENOG4105R3P Inner membrane protein yagU LH89_09900 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein LH89_09910 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component LH89_09920 ENOG4105GMB type VI secretion system effector, hcp1 family LH89_09925 ENOG4108BRW Activates expression of the rhaSR operon in response to L-rhamnose (By similarity) LH89_09930 ENOG4107S4Z Activates expression of the rhaBAD and rhaT operons (By similarity) LH89_09935 ENOG4105DET Rhamnulokinase LH89_09940 ENOG4105DKG l-rhamnose isomerase LH89_09945 ENOG4105C9J Catalyzes the reversible cleavage of L-rhamnulose-1- phosphate to dihydroxyacetone phosphate (DHAP) and L-lactaldehyde (By similarity) LH89_09960 ENOG4105C8Q Methyl-accepting chemotaxis LH89_09965 ENOG4105J4Q Transcriptional regulator LH89_09970 ENOG41077A9 carbonic anhydrase LH89_09975 ENOG4105CHH sulfate transporter LH89_09980 ENOG4105EST Metal Dependent Phosphohydrolase LH89_09990 ENOG4105G7T Catalyzes the Claisen rearrangement of chorismate to prephenate (By similarity) LH89_09995 ENOG4105EW9 transcriptional regulator AsnC family LH89_10005 ENOG4108M0I Transcriptional regulator LH89_10015 ENOG4108JQ7 (ABC) transporter LH89_10020 ENOG4105C3U ABC transporter LH89_10025 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component LH89_10030 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component LH89_10035 ENOG4105DEF Extracellular solute-binding protein, family 5 LH89_10045 ENOG4105C0R drug resistance transporter emrb qaca subfamily LH89_10055 ENOG4108ZUB Lysine exporter protein (Lyse ygga) LH89_10060 ENOG4108RVA ribokinase LH89_10070 ENOG4105UP7 3-epimerase LH89_10075 ENOG4105F5R ABC transporter LH89_10080 ENOG4105CNN ABC, transporter LH89_10085 ENOG4105C2J ABC transporter LH89_10095 ENOG4105E98 transcriptional regulator DeoR family LH89_10125 ENOG4105YCT UPF0386 protein LH89_10140 ENOG4108K5H permease YjgP YjgQ family protein LH89_10145 ENOG4108M8S permease YjgP YjgQ family protein LH89_10150 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) LH89_10155 ENOG4105MYG DNA polymerase iii, chi subunit LH89_10160 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) LH89_10165 ENOG4105C8Q Methyl-accepting chemotaxis LH89_10170 ENOG4105DWV Homoserine O-trans-acetylase LH89_10175 ENOG4108HF7 Gcn5-related n-acetyltransferase LH89_10185 ENOG4108MJ3 acetyltransferase LH89_10190 ENOG4105KQT Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome (By similarity) LH89_10195 ENOG4105DBV ornithine carbamoyltransferase LH89_10200 ENOG4105CS2 ec 3.2.1.21 LH89_10205 ENOG4105C5Y PTS System LH89_10210 ENOG4105XEP YhcH YjgK YiaL family protein LH89_10215 ENOG4105CXT aspartate transcarbamylase LH89_10220 ENOG4108R9M Involved in allosteric regulation of aspartate carbamoyltransferase (By similarity) LH89_10225 ENOG4105KME endoribonuclease L-psp LH89_10260 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component LH89_10265 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component LH89_10270 ENOG4107QSI ABC, transporter LH89_10280 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase LH89_10285 ENOG4108RDD Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine (By similarity) LH89_10290 ENOG4108ZPB UPF0306 protein LH89_10295 ENOG4105C8Q Methyl-accepting chemotaxis LH89_10300 ENOG4105PWE CRISPR-associated protein cas2 LH89_10305 ENOG4105TZK CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. May be involved in the integration of spacer DNA into the CRISPR cassette (By similarity) LH89_10315 ENOG4108VWQ crispr-associated protein LH89_10320 ENOG41060M0 Crispr-associated protein, cse4 family LH89_10350 ENOG4105D7K pfkb domain protein LH89_10355 ENOG4108M0B Sucrose porin LH89_10370 ENOG4105WBN Transcriptional regulator (LacI family LH89_10380 ENOG4108ZZF transport protein (ExbD) LH89_10385 ENOG4105CWK Biopolymer transport protein, ExbB LH89_10390 ENOG4105C28 cystathionine LH89_10395 ENOG4108K81 inner membrane protein YghB LH89_10400 ENOG4105CF7 AraC family transcriptional regulator LH89_10405 ENOG4108DBC nitroreductase LH89_10410 ENOG4108I6A alcohol dehydrogenase LH89_10415 ENOG4105CV8 reductase LH89_10420 ENOG4107TZ2 Cell division protein that is required for growth during stress conditions. May be involved in protecting or stabilizing the divisomal assembly under conditions of stress (By similarity) LH89_10425 ENOG4107S7E 1-acyl-sn-glycerol-3-phosphate acyltransferase LH89_10430 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) LH89_10435 ENOG4105NF4 modulator of drug activity LH89_10440 ENOG4105HEI LysR family (Transcriptional regulator LH89_10460 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) LH89_10465 ENOG4105IPS esterase LH89_10470 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) LH89_10475 ENOG4108SX3 cytoplasmic protein LH89_10480 ENOG41087AY ADP-Ribose pyrophosphatase LH89_10485 ENOG4105DFG type I secretion outer membrane protein LH89_10490 ENOG4105F1G UPF0441 protein LH89_10495 ENOG4106032 Glutathionylspermidine synthase LH89_10500 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b LH89_10505 ENOG4105F9E Shikimate 5-dehydrogenase LH89_10510 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) LH89_10515 ENOG4105E1C Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1A (PBP1a) (By similarity) LH89_10520 ENOG41082RQ UPF0102 protein LH89_10525 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) LH89_10530 ENOG4105W4M Transport-associated protein LH89_10540 ENOG4108VKV Monofunctional biosynthetic peptidoglycan transglycosylase LH89_10545 ENOG4108556 Isoprenoid biosynthesis protein with amidotransferase-like domain LH89_10550 ENOG4105BZU Histidine kinase LH89_10555 ENOG4105N5T Radical SAM Protein LH89_10560 ENOG4105CBC glutamate synthase LH89_10565 ENOG4105BZ8 glutamate synthase LH89_10575 ENOG4105KB2 stringent starvation protein b LH89_10580 ENOG4107MKT Stringent starvation protein a LH89_10585 ENOG4108UJD 30S ribosomal protein S9 LH89_10590 ENOG4108UM5 This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity) LH89_10600 ENOG4105D6Z AFG1 family ATPase LH89_10605 ENOG4108W2Q Cytochrome d ubiquinol oxidase subunit III LH89_10610 ENOG4105C0H protease LH89_10615 ENOG4105C0H protease LH89_10620 ENOG4105CDF Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine (By similarity) LH89_10625 ENOG4105VFK BolA family LH89_10630 ENOG4105UE2 Part of the ABC transporter complex MlaFEDB that actively prevents phospholipid accumulation at the cell surface. Probably maintains lipid asymmetry in the outer membrane by retrograde trafficking of phospholipids from the outer membrane to the inner membrane LH89_10635 ENOG4105E3I toluene tolerance LH89_10640 ENOG4107PE3 Mammalian cell entry related domain protein LH89_10645 ENOG4105CY3 ABC transporter, permease LH89_10650 ENOG4105DHJ ABC, transporter LH89_10655 ENOG4105FEU K -dependent Na -Ca exchanger LH89_10660 ENOG4105C2X Arabinose 5-phosphate isomerase LH89_10665 ENOG4108Z4R 3-deoxy-d-manno-octulosonate 8-phosphate phosphatase LH89_10670 ENOG4108P1K Required for the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane (By similarity) LH89_10675 ENOG4105WI0 lipopolysaccharide transport periplasmic protein lptA LH89_10680 ENOG4108IUZ ABC transporter LH89_10685 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) LH89_10690 ENOG41080QH sigma 54 modulation protein ribosomal protein S30EA LH89_10695 ENOG4107RM2 PTS IIA-like nitrogen-regulatory protein PtsN LH89_10700 ENOG4105C21 Displays ATPase and GTPase activities (By similarity) LH89_10705 ENOG41080Z8 PHOSPHOCARRIER protein LH89_10710 ENOG4105NXH GreA GreB family elongation factor LH89_10715 ENOG4105CMS peptidase U62, modulator of DNA gyrase LH89_10720 ENOG4105N42 UPF0307 protein LH89_10735 ENOG4107Z11 Efflux pump whose substrates are p-hydroxybenzoic acid (pHBA), 6-hydroxy-2-naphthoic and 2-hydroxycinnamate. Could function as a metabolic relief valve, allowing to eliminate certain compounds when they accumulate to high levels in the cell (By similarity) LH89_10740 ENOG4105Y49 secretion protein, HlyD family LH89_10745 ENOG4105ZQC membrane protein AaeX LH89_10750 ENOG4105CR8 Transcriptional regulator LH89_10755 ENOG4105D1U peptidase U62 modulator of DNA gyrase LH89_10760 ENOG4105QD6 exported protein LH89_10765 ENOG4105C03 ribonuclease LH89_10775 ENOG4105VQ7 Rod shape-determining protein MreD LH89_10780 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) LH89_10785 ENOG4105DFF Rod shape-determining protein mreb LH89_10790 ENOG41062P1 Diguanylate cyclase phosphodiesterase LH89_10795 ENOG4105D3Z quinone oxidoreductase, yhdh yhfp family LH89_10800 ENOG4105CCD The exact function is not known. Can catalyze the reduction of a variety of substrates like dimethyl sulfoxide, trimethylamine N-oxide, phenylmethyl sulfoxide and L-methionine sulfoxide. Cannot reduce cyclic N-oxides. Shows no activity as sulfite oxidase (By similarity) LH89_10805 ENOG4105DQ2 Is probably involved in the electron transfer between its heme and the molybdenum cofactor of the reductase catalytic subunit YedY (By similarity) LH89_10810 ENOG4108Z38 Catalyzes a trans-dehydration via an enolate intermediate (By similarity) LH89_10815 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein LH89_10820 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase LH89_10825 ENOG4105RG0 Membrane LH89_10830 ENOG4108IA2 Sodium pantothenate symporter LH89_10835 ENOG4105F59 Methylates ribosomal protein L11 (By similarity) LH89_10845 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) LH89_10850 ENOG4105VY0 Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters (By similarity) LH89_10855 ENOG4105DQ4 alcohol dehydrogenase LH89_10860 ENOG4105EMU Dehydrogenase LH89_10870 ENOG4105EQ2 LysR family Transcriptional regulator LH89_10875 ENOG4105EMU Dehydrogenase LH89_10885 ENOG4105EAB amino acid AbC transporter LH89_10890 ENOG4105E5Q amino acid AbC transporter LH89_10895 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) LH89_10905 ENOG4105EZ7 amino acid ABC transporter LH89_10910 ENOG4105DRP amino acid AbC transporter LH89_10915 ENOG4105CDA abc transporter atp-binding protein LH89_10950 ENOG4105DC1 bifunctional purine biosynthesis protein purh LH89_10955 ENOG4105C12 Phosphoribosylglycinamide synthetase LH89_10960 ENOG4108T8B Protein of unknown function (DUF1481) LH89_10965 ENOG4105K70 DNA-binding protein LH89_10970 ENOG4105R2J Conserved Protein LH89_10975 ENOG4105Y7X Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. Acts in DNA repair (By similarity) LH89_10980 ENOG4105CFZ Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III (By similarity) LH89_10985 ENOG4105E09 nadh pyrophosphatase LH89_10990 ENOG4108ZVW Anti-RNA polymerase sigma 70 factor LH89_10995 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) LH89_11000 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) LH89_11005 ENOG4105D06 uba thif-type nad fad binding protein LH89_11010 ENOG4105WHD thiamine biosynthesis protein ThiS LH89_11015 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) LH89_11020 ENOG4105D41 biosynthesis protein thiH LH89_11040 ENOG4108S1C Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein) LH89_11045 ENOG4105EQW The exact function is not known. Can catalyze the reduction of a variety of substrates like dimethyl sulfoxide, trimethylamine N-oxide, phenylmethyl sulfoxide and L-methionine sulfoxide. Cannot reduce cyclic N-oxides. Shows no activity as sulfite oxidase (By similarity) LH89_11050 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family LH89_11070 ENOG4105D27 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) LH89_11090 ENOG4105C64 Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release (By similarity) LH89_11095 ENOG4108UIK This protein binds directly to 23S ribosomal RNA (By similarity) LH89_11100 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) LH89_11105 ENOG4105PM1 preprotein translocase subunit SecE LH89_11110 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) LH89_11145 ENOG4105CS9 pantothenic acid kinase LH89_11150 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase LH89_11180 ENOG4108RR8 protoporphyrinogen oxidase LH89_11185 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) LH89_11190 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein LH89_11195 ENOG4105D9Y Splits dipeptides with a prolyl residue in the C- terminal position (By similarity) LH89_11200 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase LH89_11205 ENOG4105CHU acetyl-coa acetyltransferase LH89_11220 ENOG41080HT Transcriptional regulator, arsr family LH89_11230 ENOG4107QK7 reductase LH89_11235 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) LH89_11240 ENOG4105MDZ Transcriptional activator rfaH LH89_11245 ENOG4105D52 delta-aminolevulinic acid dehydratase LH89_11250 ENOG4105F8V Hydrolase, tatD family LH89_11255 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) LH89_11265 ENOG4105WKS Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) LH89_11270 ENOG4105CNK Required, probably indirectly, for the hydroxylation of 2-octaprenylphenol to 2-octaprenyl-6-hydroxy-phenol, the fourth step in ubiquinone biosynthesis (By similarity) LH89_11275 ENOG4105JC1 sterol-binding domain protein LH89_11280 ENOG4105DDZ Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity) LH89_11285 ENOG4105CGY Dna recombination protein LH89_11290 ENOG4105CH7 arginosuccinase LH89_11295 ENOG4105CAS nag kinase LH89_11300 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase LH89_11305 ENOG4105CWC Acetylornithine deacetylase LH89_11310 ENOG4105CCA Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity) LH89_11330 ENOG4108I5U Uridine phosphorylase LH89_11335 ENOG4105CDZ Carboxymethylenebutenolidase (EC 3.1.1.45) LH89_11340 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) LH89_11345 ENOG4105DZ2 Transcriptional regulator LH89_11360 ENOG41079UR PagP is required both for biosynthesis of hepta-acylated lipid A species containing palmitate and for resistance to cationic antimicrobial peptides (CAMPs). It catalyzes the transfer of a palmitate chain (16 0) from the sn-1 position of a glycerophospholipid to the free hydroxyl group of the (R)-3- hydroxymyristate chain at position 2 of lipid A (endotoxin) (By similarity) LH89_11365 ENOG4105D7W serine acetyltransferase LH89_11370 ENOG4105CSF NADPH-dependent glycerol-3-phosphate dehydrogenase LH89_11375 ENOG4105IX2 One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA (By similarity) LH89_11380 ENOG4107YZP Rhodanese domain protein LH89_11385 ENOG41063SB peptidase LH89_11390 ENOG4105PXI polysaccharide deacetylase LH89_11395 ENOG4105CPQ Dehydrogenase LH89_11400 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) LH89_11405 ENOG4105CUI Catalyzes the interconversion between ADP-D-glycero- beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose via an epimerization at carbon 6 of the heptose (By similarity) LH89_11410 ENOG4105XA0 heptosyltransferase ii LH89_11415 ENOG4105D16 lipopolysaccharide heptosyltransferase i LH89_11420 ENOG4105DKP glycosyl transferase, family 9 LH89_11440 ENOG4105CPK Glycosyl transferase (Group 1 LH89_11450 ENOG4105D8A 3-Deoxy-D-manno-octulosonic-acid transferase LH89_11460 ENOG4108ZEF Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity) LH89_11465 ENOG4105K64 Glycosyl transferase, family 2 LH89_11470 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) LH89_11475 ENOG4105W0E 50S ribosomal protein L33 LH89_11480 ENOG4105KDC 50s ribosomal protein l28 LH89_11485 ENOG4105W5Q DNA repair protein (RadC LH89_11490 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase LH89_11495 ENOG4108Z1K This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) LH89_11500 ENOG4105EC0 Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. SlmA-DNA-binding sequences (SBS) are dispersed on non-Ter regions of the chromosome, preventing FtsZ polymerization at these regions (By similarity) LH89_11505 ENOG4107QP2 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) LH89_11510 ENOG4105ED0 Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates (By similarity) LH89_11515 ENOG4105VG5 Membrane LH89_11530 ENOG4107S8C mandelate racemase muconate lactonizing LH89_11535 ENOG4108JQ6 ABC transporter LH89_11540 ENOG4105DEF Extracellular solute-binding protein, family 5 LH89_11545 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component LH89_11550 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component LH89_11565 ENOG4105D44 asparaginase LH89_11590 ENOG4108JQ7 (ABC) transporter LH89_11595 ENOG4105C3U ABC transporter LH89_11600 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component LH89_11605 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component LH89_11610 ENOG4105DEF Extracellular solute-binding protein, family 5 LH89_11615 ENOG4108IGT Dipeptidase LH89_11620 ENOG4105RQF LysR family Transcriptional regulator LH89_11625 ENOG4105DSJ YicC domain protein LH89_11670 ENOG4107YC3 synthase LH89_11675 ENOG4105VJY transcriptional regulator LH89_11695 ENOG4105CEY Amp-dependent synthetase and ligase LH89_11730 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) LH89_11760 ENOG4107TUY Histidine kinase LH89_11765 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family LH89_11770 ENOG4107R34 abc transporter permease protein LH89_11775 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) LH89_11780 ENOG4106AXJ AraC family transcriptional regulator LH89_11820 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) LH89_11825 ENOG4105D53 Catalyzes the hydrolysis of pseudouridine 5'-phosphate (PsiMP) to ribose 5-phosphate and uracil (By similarity) LH89_11830 ENOG4108KTG Membrane protein, drug metabolite transporter LH89_11835 ENOG4108ZT1 Transcriptional regulator LH89_11840 ENOG4105CDH Citrulline--aspartate ligase LH89_11845 ENOG41061MD high-affinity nickel-transporter LH89_11860 ENOG4105T16 Transcriptional regulator (AraC family) LH89_11865 ENOG4107RNG ABC transporter LH89_11870 ENOG4105C2J ABC transporter LH89_11875 ENOG4105DFW ABC transporter LH89_11880 ENOG4105C93 Xylose Isomerase LH89_11885 ENOG4105CMG Carbohydrate kinase LH89_11890 ENOG4105C26 Dehydrogenase LH89_11895 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) LH89_11900 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) LH89_11905 ENOG4105C8Q Methyl-accepting chemotaxis LH89_11910 ENOG4105E61 Mannitol repressor protein LH89_11915 ENOG4107SQ3 mannitol-1-phosphate 5-dehydrogenase LH89_11920 ENOG4105CTS PTS system mannitol-specific LH89_11940 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) LH89_11970 ENOG4105CNA YD repeat protein LH89_11980 ENOG4105CS6 Rhs element vgr protein LH89_11985 ENOG4108WC9 type VI secretion system effector, hcp1 family LH89_11990 ENOG4105C0R drug resistance transporter emrb qaca subfamily LH89_11995 ENOG4105C38 Glycyl-tRNA synthetase beta subunit LH89_12000 ENOG4108HMW glycyl-tRNA synthetase, alpha subunit LH89_12005 ENOG4105HF0 Membrane LH89_12010 ENOG4108R3E Dna-3-methyladenine glycosylase i LH89_12015 ENOG4105HNP -acetyltransferase LH89_12020 ENOG4105C5I Dehydrogenase LH89_12035 ENOG4105JKW Valine--pyruvate aminotransferase LH89_12055 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component LH89_12060 ENOG4108JQ6 ABC transporter LH89_12080 ENOG4105CHC glucokinase (EC 2.7.1.2) LH89_12100 ENOG4108M0I Transcriptional regulator LH89_12110 ENOG4105FCD Major Facilitator LH89_12115 ENOG4105CFN oxalyl-CoA decarboxylase LH89_12125 ENOG4105BZU Histidine kinase LH89_12130 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F LH89_12150 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein LH89_12160 ENOG4107R8H Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) LH89_12165 ENOG4108YXU transcriptional regulator AsnC family LH89_12175 ENOG4105FDP GntR family transcriptional regulator LH89_12180 ENOG4107RAW 3-carboxy-cis-cis-muconate cycloisomerase LH89_12185 ENOG4107QPK )-transporter LH89_12190 ENOG4105DC8 reductase LH89_12200 ENOG4105IES Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (By similarity) LH89_12205 ENOG4105D6S protein involved in catabolism of external DNA LH89_12215 ENOG4105DGW oligopeptidase A LH89_12220 ENOG4105FFN Specifically methylates the guanosine in position 1516 of 16S rRNA (By similarity) LH89_12235 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) LH89_12240 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) LH89_12245 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) LH89_12250 ENOG4105CI4 it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity) LH89_12255 ENOG4105NVJ RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity) LH89_12260 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins LH89_12265 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) LH89_12275 ENOG41061P8 Persistence to inhibition of murein or DNA biosynthesis regulatory protein LH89_12280 ENOG4105E7U AraC family transcriptional regulator LH89_12285 ENOG4105IGJ Zn-dependent Hydrolase of the beta-lactamase fold protein LH89_12295 ENOG4105KVH Transcriptional regulator LH89_12300 ENOG4108RYK Nad-dependent epimerase dehydratase LH89_12315 ENOG4105PE8 Translocates 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol (alpha-L-Ara4N-phosphoundecaprenol) from the cytoplasmic to the periplasmic side of the inner membrane (By similarity) LH89_12320 ENOG41060GT Translocates 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol (alpha-L-Ara4N-phosphoundecaprenol) from the cytoplasmic to the periplasmic side of the inner membrane (By similarity) LH89_12325 ENOG4105SA9 Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity) LH89_12330 ENOG4105F73 Catalyzes the deformylation of 4-deoxy-4-formamido-L- arabinose-phosphoundecaprenol to 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity) LH89_12335 ENOG4105C3I Nad-dependent epimerase dehydratase LH89_12340 ENOG4105CKK Glycosyl transferase, family 2 LH89_12350 ENOG4105BZ8 glutamate synthase LH89_12355 ENOG4108RC0 Electron transport protein LH89_12360 ENOG4107YAK holo-(acyl carrier protein) synthase 2 LH89_12365 ENOG4105C7N Xanthine uracil vitamin C permease LH89_12370 ENOG4107UB3 HAD-superfamily hydrolase subfamily IA variant 3 LH89_12375 ENOG4105DRP amino acid AbC transporter LH89_12380 ENOG4105EAD ABC transporter LH89_12385 ENOG4106PMH Extracellular solute-binding protein family 3 LH89_12395 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) LH89_12400 ENOG4105E2Z phosphate ABC transporter (Permease LH89_12405 ENOG4105C8U phosphate abc transporter LH89_12410 ENOG4107QMV Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity) LH89_12415 ENOG4105BZU Histidine kinase LH89_12430 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain LH89_12465 ENOG4107T1C Catalyzes the conversion of GTP to 2,5-diamino-6- ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate (By similarity) LH89_12470 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) LH89_12475 ENOG4105C2D reductase LH89_12485 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) LH89_12510 ENOG4105CKK Glycosyl transferase, family 2 LH89_12515 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) LH89_12560 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) LH89_12565 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) LH89_12575 ENOG4105KNM Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity) LH89_12580 ENOG4105C4J Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity) LH89_12585 ENOG4105J80 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity) LH89_12590 ENOG4105CDG Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity) LH89_12595 ENOG4107S15 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) LH89_12600 ENOG4107Z6K F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) LH89_12605 ENOG4105KY6 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) LH89_12610 ENOG4105EE4 it plays a direct role in the translocation of protons across the membrane (By similarity) LH89_12615 ENOG4105GXX Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit I associates with the membrane and may be involved with cation translocation LH89_12620 ENOG4105D28 Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity) LH89_12625 ENOG4107RE5 NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity) LH89_12630 ENOG4105QTB Flavodoxin LH89_12635 ENOG4108VVK transcriptional Regulator, AsnC LH89_12640 ENOG4105EV2 VWA domain protein interacting with AAA ATPase LH89_12645 ENOG4107R4Q Functions as an ATPase. May play a role in metal insertion (metal-chelatase) or as a chaperone (By similarity) LH89_12650 ENOG4105DFH Transport of potassium into the cell (By similarity) LH89_12655 ENOG4105DHQ Histidine kinase LH89_12660 ENOG4105XJC Two component transcriptional regulator (Winged helix family LH89_12665 ENOG4105H4F exported protein LH89_12670 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) LH89_12675 ENOG4105C2J ABC transporter LH89_12680 ENOG4105CNN ABC, transporter LH89_12685 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator LH89_12690 ENOG4108RVA ribokinase LH89_12695 ENOG4105ETE Transcriptional regulator (LacI family LH89_12720 ENOG4105FNP Molybdopterin-guanine dinucleotide biosynthesis protein b LH89_12730 ENOG4105PC1 Conserved Protein LH89_12735 ENOG4105E27 serine threonine protein kinase LH89_12740 ENOG4108Z33 Thiol disulfide Interchange Protein LH89_12745 ENOG4105C2M dna polymerase I LH89_12750 ENOG4105WHM Necessary for normal cell division and for the maintenance of normal septation (By similarity) LH89_12755 ENOG4105ZR3 A GTPase-activating protein (GAP) that modifies Der EngA GTPase function. May play a role in ribosome biogenesis (By similarity) LH89_12765 ENOG4105D4P Coproporphyrinogen iii oxidase LH89_12775 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family LH89_12780 ENOG4105CUX Signal transduction histidine kinase LH89_12785 ENOG4105C5F glutamine synthetase LH89_12795 ENOG4105EJU HAD-superfamily hydrolase subfamily IA variant 3 LH89_12800 ENOG4108YYA Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity) LH89_12805 ENOG4105SUU thioesterase domain LH89_12810 ENOG4105JV1 AsmA family LH89_12815 ENOG4105C2W permease LH89_12820 ENOG4105CB5 ATP-dependent DNA helicase recG LH89_12825 ENOG4105FE8 tRNA (Guanosine-2'-O-)-methyltransferase LH89_12830 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) LH89_12835 ENOG4105VFG Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) LH89_12840 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) LH89_12845 ENOG410649J Catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction (By similarity) LH89_12850 ENOG4105DIJ Phosphoethanolamine transferase LH89_12865 ENOG4105EMU Dehydrogenase LH89_12880 ENOG4105JQN Transcriptional regulator LH89_12895 ENOG4105F0P binding-protein-dependent transport systems inner membrane Component LH89_12905 ENOG4105BZ7 extracellular solute-binding protein family 1 LH89_12930 ENOG4105BZC d-serine deaminase LH89_12965 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) LH89_12980 ENOG4105CBX hi0933 family LH89_12985 ENOG4105CJ3 phosphate transporter LH89_12990 ENOG4108V6B universal stress protein B LH89_12995 ENOG4108M6U Universal stress protein A LH89_13000 ENOG4105C8Q Methyl-accepting chemotaxis LH89_13010 ENOG410667J hydrolase LH89_13015 ENOG4105CHZ Catalyzes the dehydration of D-mannonate (By similarity) LH89_13045 ENOG4105VR4 UPF0379 protein ybiJ LH89_13050 ENOG4105D99 atp gtp-binding protein LH89_13060 ENOG4105EF1 ribulokinase LH89_13070 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) LH89_13080 ENOG4105CSH Transporter LH89_13085 ENOG4105WBN Transcriptional regulator (LacI family LH89_13090 ENOG4105R2A (LipO)protein LH89_13095 ENOG4108ZNX Heat shock protein LH89_13100 ENOG4108SHS Associates with aggregated proteins, together with IbpA, to stabilize and protect them from irreversible denaturation and extensive proteolysis during heat shock and oxidative stress. Aggregated proteins bound to the IbpAB complex are more efficiently refolded and reactivated by the ATP-dependent chaperone systems ClpB and DnaK DnaJ GrpE. Its activity is ATP- independent (By similarity) LH89_13105 ENOG4107QPK )-transporter LH89_13110 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism LH89_13115 ENOG4108MRH transcriptional regulatory protein LH89_13125 ENOG4105DEF Extracellular solute-binding protein, family 5 LH89_13130 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component LH89_13135 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component LH89_13140 ENOG4105C3U ABC transporter LH89_13145 ENOG4108JQ7 (ABC) transporter LH89_13160 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family LH89_13170 ENOG4105D29 Helix-turn-helix type 11 domain protein LH89_13175 ENOG4108594 Permease of the drug metabolite transporter LH89_13200 ENOG4105EJG cellulose synthase LH89_13210 ENOG4105K2Z endo-1,4-d-glucanase (EC 3.2.1.4) LH89_13215 ENOG4105CK2 sodium dicarboxylate symporter LH89_13220 ENOG4105CS0 peptidase LH89_13225 ENOG4107SS6 2-dehydro-3-deoxygluconokinase LH89_13230 ENOG4105VSH 4-oxalocrotonate tautomerase LH89_13235 ENOG4107H3J ribonuclease LH89_13240 ENOG4105F9N Major Facilitator Superfamily LH89_13245 ENOG4108W1V Lipoprotein LH89_13250 ENOG4105EX9 Membrane LH89_13255 ENOG41082K8 Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Interacts with IscS and stimulates its activity. Then, accepts a sulfur from IscS and transfers it in turn to TusD (By similarity) LH89_13260 ENOG4107FS9 Membrane LH89_13270 ENOG4105MG3 Membrane LH89_13275 ENOG4106H78 methyltransferase LH89_13280 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) LH89_13280 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) LH89_13285 ENOG4105CAK Cell division ATP-binding protein ftsE LH89_13290 ENOG4105CRP Part of the ABC transporter FtsEX involved in LH89_13305 ENOG4105CP9 extracellular ligand-binding receptor LH89_13310 ENOG4105C32 Amino acid ABC transporter (Permease) LH89_13315 ENOG4105CF8 branched-chain amino acid ABC transporter, permease LH89_13320 ENOG4105C0Z ABC transporter LH89_13325 ENOG4108IV0 ABC, transporter LH89_13330 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family LH89_13340 ENOG4107GFK fumarate LH89_13345 ENOG4106DSS Tartrate dehydratase subunit alpha LH89_13360 ENOG4105C8Q Methyl-accepting chemotaxis LH89_13370 ENOG4105C8Q Methyl-accepting chemotaxis LH89_13375 ENOG4105C8Q Methyl-accepting chemotaxis LH89_13380 ENOG4105C8Q Methyl-accepting chemotaxis LH89_13385 ENOG4105C8Q Methyl-accepting chemotaxis LH89_13395 ENOG4105BZ7 extracellular solute-binding protein family 1 LH89_13400 ENOG4105E4X binding-protein-dependent transport systems inner membrane Component LH89_13405 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component LH89_13410 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) LH89_13415 ENOG4107T6V glycerophosphoryl diester phosphodiesterase LH89_13420 ENOG4107TT2 Auxin Efflux Carrier LH89_13430 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) LH89_13450 ENOG4105E0F Histidine kinase LH89_13455 ENOG4105E3W Two component transcriptional regulator (Winged helix family LH89_13460 ENOG4105FMW periplasmic LH89_13475 ENOG4105CMM transposase LH89_13515 ENOG4105PTU response to oxidative stress LH89_13520 ENOG41062IR nudix hydrolase LH89_13530 ENOG41076HS cation diffusion facilitator family transporter LH89_13535 ENOG4105CTQ phosphohexokinase LH89_13545 ENOG4105DCY Is an aliphatic amidase with a restricted substrate specificity, as it only hydrolyzes formamide (By similarity) LH89_13550 ENOG4105DWY Agmatine deiminase LH89_13555 ENOG4105G6Z alkaline phosphatase LH89_13560 ENOG4105CP7 Triose-phosphate isomerase LH89_13565 ENOG4105EBK exported protein LH89_13570 ENOG4108VTS Membrane LH89_13575 ENOG4105DP0 ferredoxin-NADP reductase LH89_13580 ENOG4105CBT Fructose-1,6-bisphosphatase LH89_13590 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) LH89_13595 ENOG4105N4M Non-essential, abundant cell division factor that is required for proper Z-ring formation. It is recruited early to the divisome by direct interaction with FtsZ, stimulating Z-ring assembly and thereby promoting cell division earlier in the cell cycle. Its recruitment to the Z-ring requires functional FtsA or ZipA (By similarity) LH89_13600 ENOG4108YYX Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome. Modulates RNA-binding and helicase activities of the degradosome (By similarity) LH89_13605 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase LH89_13610 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) LH89_13615 ENOG4108R5P Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery (By similarity) LH89_13620 ENOG41063M6 Cell Division Protein LH89_13625 ENOG4105ETE Transcriptional regulator (LacI family LH89_13630 ENOG4105C25 Primosomal protein n' LH89_13640 ENOG4105GGQ This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis (By similarity) LH89_13645 ENOG4105C28 cystathionine LH89_13650 ENOG4105CFH Aspartokinase LH89_13655 ENOG4105SYT Methylenetetrahydrofolate reductase LH89_13660 ENOG4105EHV domain protein LH89_13670 ENOG4105DX1 Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation (By similarity) LH89_13680 ENOG4108Y73 Membrane LH89_13685 ENOG4107R9T Catalyzes the formation of 5-methyl-uridine at position 54 (m5U54) in all tRNAs (By similarity) LH89_13695 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) LH89_13735 ENOG4105CVI Transcriptional regulator LH89_13740 ENOG4108WFC UPF0438 protein yifE LH89_13745 ENOG4105C0P Mg chelatase subunit ChlI LH89_13750 ENOG4105JHE Major Facilitator Superfamily LH89_13760 ENOG4105P3Y Acetolactate synthase 2 regulatory subunit LH89_13765 ENOG4105CM2 brancheD-chain amino acid aminotransferase LH89_13775 ENOG4105C7B Threonine dehydratase LH89_13790 ENOG4105EMY transcriptional regulator LH89_13795 ENOG4105C6M Alpha-keto-beta-hydroxylacyl reductoisomerase LH89_13805 ENOG4105CK7 Sodium proline symporter LH89_13810 ENOG4105C26 Dehydrogenase LH89_13815 ENOG4105KQ5 peptidylprolyl cis-trans isomerase LH89_13820 ENOG4105C4R Atp-dependent dna helicase LH89_13830 ENOG4105C9X ppx gppa phosphatase LH89_13835 ENOG4105C1J atp-dependent rna helicase LH89_13840 ENOG4105K63 Thioredoxin LH89_13850 ENOG4105ESV Glycosyl transferase, family 4 LH89_13855 ENOG4105SFE lipopolysaccharide biosynthesis protein LH89_13860 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase LH89_13865 ENOG4108IJ1 Dehydrogenase LH89_13875 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase LH89_13880 ENOG4105EGZ biosynthesis protein LH89_13885 ENOG4105F18 Catalyzes the synthesis of Und-PP-GlcNAc-ManNAcA-Fuc4NAc (Lipid III), the third lipid-linked intermediate involved in ECA synthesis (By similarity) LH89_13890 ENOG4105DAD Could be involved in ECA polysaccharide chain elongation (By similarity) LH89_13895 ENOG4108UHC Glycosyl transferase, wecb taga cpsf family LH89_13900 ENOG4105C85 amino acid LH89_13930 ENOG4105C83 adenylosuccinate lyase LH89_13935 ENOG4108XSB acetyltransferase, (GNAT) family LH89_13940 ENOG4105EAB amino acid AbC transporter LH89_13945 ENOG4108HW4 amino acid AbC transporter LH89_13955 ENOG4105CH2 amidohydrolase LH89_13960 ENOG4105CDA abc transporter atp-binding protein LH89_13970 ENOG4105EZ7 amino acid ABC transporter LH89_13995 ENOG4105DRR Transcriptional regulator, GntR family LH89_14000 ENOG410601J HemY protein LH89_14005 ENOG4105ECF c-methyltransferase LH89_14010 ENOG41076E6 Uroporphyrinogen-III Synthase LH89_14015 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) LH89_14035 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) LH89_14040 ENOG4105CT0 Protein of unknown function, DUF484 LH89_14050 ENOG4105DFC had-superfamily hydrolase, subfamily ia, variant LH89_14055 ENOG4105C4R Atp-dependent dna helicase LH89_14060 ENOG4107QUT magnesium and cobalt transport protein CorA LH89_14065 ENOG4108KK1 membrane protein AbrB duplication LH89_14070 ENOG4105FR1 rard protein LH89_14075 ENOG4108VUY thioesterase Superfamily protein LH89_14080 ENOG4105HDD phospholipase LH89_14085 ENOG4105C9U ATP-dependent DNA helicase RecQ LH89_14090 ENOG4105CCF Lysine exporter protein (Lyse ygga) LH89_14110 ENOG4108EUD Lysophospholipase LH89_14115 ENOG4105DQF Hydrolase LH89_14120 ENOG4106MZZ glycerophosphoryl diester phosphodiesterase LH89_14125 ENOG4105CXY transporter LH89_14130 ENOG4107R5Y anaerobic glycerol-3-phosphate dehydrogenase, subunit A LH89_14135 ENOG4108KJ0 anaerobic glycerol-3-phosphate dehydrogenase, subunit B LH89_14140 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) LH89_14145 ENOG4105C2I pirin domain protein LH89_14155 ENOG4105DIQ Transcriptional regulator LH89_14160 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family LH89_14165 ENOG4105C6Z Gluconate LH89_14170 ENOG41076UM multiple antibiotic resistance (MarC)-related protein LH89_14175 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) LH89_14180 ENOG4105MRR Transcriptional regulator (By similarity) LH89_14185 ENOG4105VEQ Cold shock protein LH89_14190 ENOG4108HRK Histidine kinase LH89_14205 ENOG4107QQ4 Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity) LH89_14210 ENOG4105CXW Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity) LH89_14215 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) LH89_14220 ENOG4105C6V Glycerol-3-phosphate dehydrogenase LH89_14225 ENOG4105M78 Catalyzes, although with low efficiency, the sulfur transfer reaction from thiosulfate to cyanide (By similarity) LH89_14230 ENOG4108I5G Major Facilitator superfamily LH89_14235 ENOG4108R66 Conserved Protein LH89_14240 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) LH89_14245 ENOG4108RVA ribokinase LH89_14250 ENOG4105EBW Rhomboid-type serine protease that catalyzes intramembrane proteolysis (By similarity) LH89_14255 ENOG4105E98 transcriptional regulator DeoR family LH89_14260 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) LH89_14265 ENOG4107RTM 4-alpha-glucanotransferase (EC 2.4.1.25) LH89_14270 ENOG4107RUK Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins (By similarity) LH89_14275 ENOG4105MJ2 Competence protein LH89_14280 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) LH89_14290 ENOG4105BZM domain protein LH89_14300 ENOG4108RRZ Transcription elongation factor GreB LH89_14305 ENOG4105DPZ Two component transcriptional regulator (Winged helix family LH89_14310 ENOG4105E0F Histidine kinase LH89_14315 ENOG4105DJ1 Phosphoenolpyruvate Carboxylase LH89_14320 ENOG4105F4C Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity) LH89_14325 ENOG4105VEJ Heat shock protein LH89_14330 ENOG4107Y3D HAD-superfamily hydrolase subfamily IA variant 3 LH89_14335 ENOG4105DQY intracellular growth attenuator LH89_14340 ENOG4107RK2 ADP-ribose diphosphatase NudE LH89_14345 ENOG4108JQC penicillin-binding protein 1A LH89_14370 ENOG4105E4G Type IV pilus LH89_14375 ENOG4105KHV Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate (By similarity) LH89_14380 ENOG4105D49 3-dehydroquinate synthase LH89_14395 ENOG4105DJV ribulose-phosphate 3-epimerase LH89_14400 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) LH89_14405 ENOG4105C31 Tryptophanyl-tRNA synthetase LH89_14410 ENOG4105CXK mandelate racemase muconate lactonizing LH89_14415 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) LH89_14435 ENOG4107SJ9 decarboxylase LH89_14455 ENOG4105NVB glycoside hydrolase, family 19 LH89_14460 ENOG4105RX7 peptidase S8 and S53, subtilisin, kexin, sedolisin LH89_14475 ENOG4105EQD regulatoR LH89_14485 ENOG4105C8Y Acetylornithine aminotransferase LH89_14495 ENOG4108UKZ OsmC family LH89_14500 ENOG4105CJE phosphoribulokinase (EC 2.7.1.19) LH89_14510 ENOG4105DNZ Alpha Beta Hydrolase LH89_14520 ENOG4105C5H ABC transporter LH89_14525 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein LH89_14530 ENOG4105CKD glutathione-regulated potassium-efflux system protein LH89_14535 ENOG4105VKU nucleicacid-binding protein LH89_14545 ENOG4108YZY peptidylprolyl cis-trans isomerase LH89_14550 ENOG4105F0F Oxalate decarboxylase LH89_14560 ENOG4105C85 amino acid LH89_14565 ENOG4105CUV Homoserine Kinase LH89_14575 ENOG4105VRX Protein slyX homolog LH89_14580 ENOG4108V1T peptidylprolyl cis-trans isomerase LH89_14595 ENOG4105DIJ Phosphoethanolamine transferase LH89_14600 ENOG4105WWK YheO domain protein LH89_14605 ENOG4108ZAT Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE (By similarity) LH89_14610 ENOG4108ZKU Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions (By similarity) LH89_14625 ENOG4108UHY One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity) LH89_14630 ENOG4105CEJ Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity) LH89_14635 ENOG4105CGV This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity) LH89_14655 ENOG4105EEE One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity) LH89_14660 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) LH89_14665 ENOG41080KG One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) LH89_14670 ENOG4105CFD One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity LH89_14675 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) LH89_14680 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) LH89_14685 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) LH89_14690 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) LH89_14700 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal LH89_14705 ENOG4108UNN Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome (By similarity) LH89_14710 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) LH89_14715 ENOG4105CW6 This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits LH89_14720 ENOG4105VBI Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site (By similarity) LH89_14725 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) LH89_14730 ENOG4108R5J This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity) LH89_14740 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) LH89_14745 ENOG4105VPB 50S ribosomal protein L30 LH89_14750 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) LH89_14755 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) LH89_14765 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits LH89_14770 ENOG4108UHH Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity) LH89_14775 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) LH89_14785 ENOG4108ZT0 50S ribosomal protein l17 LH89_14790 ENOG4105VTS DnaJ-like, subfamily C LH89_14795 ENOG4105M2E Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity) LH89_14800 ENOG4105C1A potassium transporter peripheral membrane LH89_14805 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B LH89_14810 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) LH89_14815 ENOG4108Z02 Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity) LH89_14820 ENOG4105C79 DNA protecting protein DprA LH89_14825 ENOG4108RPN Protein smg homolog LH89_14840 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) LH89_14845 ENOG4105E2X shikimate dehydrogenase LH89_14855 ENOG4108Z0R Transferase LH89_14880 ENOG4105CVG Homoserine O-transsuccinylase LH89_14885 ENOG4107QP3 malate synthase g LH89_14890 ENOG4108I9X Isocitrate lyase LH89_14895 ENOG4105VS7 Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation (By similarity) LH89_14900 ENOG41069M3 Transcriptional regulator LH89_14910 ENOG4105C3R Methionine synthase LH89_14925 ENOG4107QPK )-transporter LH89_14930 ENOG4105EAM Na Pi-cotransporter LH89_14935 ENOG4105C8Q Methyl-accepting chemotaxis LH89_14940 ENOG4105CFH Aspartokinase LH89_14945 ENOG4107QP8 phosphohexose isomerase LH89_14950 ENOG4105D3P Mannan endo-1,4-beta-mannosidase LH89_14955 ENOG4108ZVF (LipO)protein LH89_14960 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein LH89_14965 ENOG4105DRH Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity) LH89_14975 ENOG4105QNF Outer membrane lipoprotein LH89_14980 ENOG4108VP9 Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane (By similarity) LH89_14985 ENOG4108WJH Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane (By similarity) LH89_14990 ENOG4105E33 succinate dehydrogenase LH89_15000 ENOG4105CAP With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P (By similarity) LH89_15005 ENOG4105EGS Mechanosensitive ion channel LH89_15010 ENOG4105DJ4 phosphatidylserine decarboxylase LH89_15015 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) LH89_15020 ENOG4108RBP 3'-to-5' exoribonuclease specific for small oligoribonucleotides (By similarity) LH89_15080 ENOG4107Z3H Transcriptional regulator, TetR family LH89_15090 ENOG4108ESX Receptor LH89_15100 ENOG4108SF5 RNA Polymerase LH89_15105 ENOG4108S3W Anti-feci sigma factor, fecr LH89_15110 ENOG4105WQ5 TonB family LH89_15125 ENOG4105CMS peptidase U62, modulator of DNA gyrase LH89_15130 ENOG4105D1U peptidase U62 modulator of DNA gyrase LH89_15200 ENOG4105C8Q Methyl-accepting chemotaxis LH89_15280 ENOG4105DS4 PAS PAC sensor Signal transduction histidine kinase LH89_15285 ENOG4108JUA Transcriptional regulator LH89_15300 ENOG4105C8Q Methyl-accepting chemotaxis LH89_15305 ENOG4106KR7 LysR family Transcriptional regulator LH89_15315 ENOG4107RT5 aminobenzoyl-glutamate utilization protein B LH89_15320 ENOG4105CFC Transporter LH89_15325 ENOG4105K56 Transcriptional regulator LH89_15330 ENOG4108ZHJ Organic hydroperoxide resistance protein LH89_15340 ENOG4105CDA abc transporter atp-binding protein LH89_15345 ENOG4108HW4 amino acid AbC transporter LH89_15375 ENOG4105DEN Luciferase family LH89_15395 ENOG4105BZF Glycosyl transferase (Group 1 LH89_15405 ENOG4105C30 Nad-dependent epimerase dehydratase LH89_15420 ENOG4105C0K Gdp-mannose 4,6-dehydratase LH89_15440 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) LH89_15450 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) LH89_15455 ENOG4105K8N protein family UPF0079, ATPase LH89_15460 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase LH89_15465 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) LH89_15470 ENOG4105DKX Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity) LH89_15475 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) LH89_15480 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) LH89_15485 ENOG4107QJR hflk protein LH89_15490 ENOG4105EPW hflc protein LH89_15500 ENOG4105C91 Plays an important role in the de novo pathway of purine nucleotide biosynthesis LH89_15505 ENOG4105DFU Cell wall formation (By similarity) LH89_15510 ENOG4105CZI D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1 LH89_15515 ENOG4107Y66 Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity) LH89_15520 ENOG4108UJU UPF0301 protein LH89_15525 ENOG4105D7Z glutathione synthase LH89_15530 ENOG4105QF0 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) LH89_15535 ENOG4105RWS endonuclease I LH89_15540 ENOG4105GPY SprT protein LH89_15545 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP LH89_15560 ENOG4105DP5 Catalyzes the biosynthesis of agmatine from arginine (By similarity) LH89_15565 ENOG4106DTQ Protein TsgA homolog LH89_15570 ENOG4105CV1 Transketolase (EC 2.2.1.1) LH89_15575 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase LH89_15580 ENOG4105BZA Phosphoglycerate kinase LH89_15585 ENOG4105D2N Aldolase LH89_15590 ENOG4105D64 Mechanosensitive ion channel LH89_15595 ENOG4105J4Q Transcriptional regulator LH89_15600 ENOG4105MPN Membrane LH89_15605 ENOG4105CXD Specific inhibitor of chromosomal initiation of replication in vitro. Binds the three 13-mers in the origin (oriC) to block initiation of replication (By similarity) LH89_15610 ENOG4105E66 phosphoriboisomerase A LH89_15615 ENOG4108JQ1 Dehydrogenase LH89_15620 ENOG4105CIS alcohol dehydrogenase LH89_15625 ENOG4105ETT transcriptional Regulator, LysR family LH89_15630 ENOG4105C8Q Methyl-accepting chemotaxis LH89_15635 ENOG4105C5H ABC transporter LH89_15640 ENOG4107SC1 transglycosylase LH89_15645 ENOG4105R9M This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region (By similarity) LH89_15650 ENOG4108K16 Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) LH89_15655 ENOG4105CVJ phosphoglycerate mutase LH89_15660 ENOG4105UEI Transcriptional Regulator AraC Family LH89_15665 ENOG4108RH0 Crea protein LH89_15670 ENOG41065U4 response regulator LH89_15675 ENOG4106FVC RNA methyltransferase LH89_15685 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) LH89_15695 ENOG4105D1Q UPF0246 protein LH89_15700 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) LH89_15705 ENOG4105BZU Histidine kinase LH89_15710 ENOG4108RIR Molybdenum cofactor biosynthesis protein LH89_15720 ENOG4106HK8 GPR1 FUN34 yaaH family protein LH89_15730 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) LH89_15735 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) LH89_15740 ENOG41063Z6 transcriptional regulator, lysR family LH89_15745 ENOG4105KQV Binds directly to 16S ribosomal RNA (By similarity) LH89_15750 ENOG4105DTN riboflavin biosynthesis protein ribF LH89_15755 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) LH89_15760 ENOG4105M02 This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity) LH89_15765 ENOG41090X3 Peptidyl-prolyl cis-trans isomerase LH89_15770 ENOG4105C48 Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity) LH89_15785 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain LH89_15790 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain LH89_15795 ENOG4105N14 lysine exporter protein LysE YggA LH89_15800 ENOG4105DWK Membrane LH89_15805 ENOG4107XM3 UPF0442 protein LH89_15810 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) LH89_15820 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) LH89_15825 ENOG4105NWN ApaG protein LH89_15830 ENOG4105D1X Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits (By similarity) LH89_15835 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) LH89_15840 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) LH89_15845 ENOG4105E7H involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity) LH89_15850 ENOG41066UG Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host (By similarity) LH89_15855 ENOG4105D3G Pseudouridine synthase LH89_15860 ENOG4105BZK Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair (By similarity) LH89_15865 ENOG4105CQ2 DNA polymerase LH89_15875 ENOG4105C32 Amino acid ABC transporter (Permease) LH89_15880 ENOG4105CF8 branched-chain amino acid ABC transporter, permease LH89_15885 ENOG4105C0Z ABC transporter LH89_15890 ENOG4108IV0 ABC, transporter LH89_15895 ENOG4105GMB type VI secretion system effector, hcp1 family LH89_15920 ENOG4108KF1 Membrane LH89_15925 ENOG4105M71 acetolactate synthase 1 regulatory subunit LH89_15930 ENOG4105C7K acetolactate synthase LH89_15940 ENOG4107T0D ABC, transporter LH89_15945 ENOG4106SMU thiamine transporter membrane protein LH89_15950 ENOG4105DP9 ABC transporter LH89_15955 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) LH89_15965 ENOG4105C0F tryptophanase EC 4.1.99.1 LH89_15975 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) LH89_15980 ENOG4105CQI Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) LH89_15985 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) LH89_15990 ENOG4105CYQ Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate) (By similarity) LH89_15995 ENOG4108IQE Amp-dependent synthetase and ligase LH89_16000 ENOG4105C7K acetolactate synthase LH89_16005 ENOG4108ZP8 Acetolactate synthase small subunit LH89_16010 ENOG4107B7Y DNA-binding transcriptional regulator FruR LH89_16015 ENOG4108RNS Exports L-alanine (By similarity) LH89_16025 ENOG4108V6E Cell division protein mraZ LH89_16030 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) LH89_16035 ENOG41063Y6 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) LH89_16040 ENOG4105CJN penicillin-binding protein LH89_16045 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) LH89_16050 ENOG4108EQQ Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity) LH89_16055 ENOG4105CPY First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan (By similarity) LH89_16060 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) LH89_16065 ENOG4105CNI cell division protein FtsW LH89_16070 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) LH89_16075 ENOG4105DFU Cell wall formation (By similarity) LH89_16080 ENOG4105K7E Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity) LH89_16085 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) LH89_16090 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) LH89_16095 ENOG4105C7C involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) LH89_16105 ENOG4108SR7 Regulates secA expression by translational coupling of the secM secA operon. Translational pausing at a specific Pro residue 5 residues before the end of the protein may allow disruption of a mRNA repressor helix that normally suppresses secA translation initiation (By similarity) LH89_16110 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving LH89_16115 ENOG4105M6F mutator MutT protein LH89_16120 ENOG41067SF Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase (By similarity) LH89_16125 ENOG4105DHA Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity (By similarity) LH89_16130 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) LH89_16135 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) LH89_16140 ENOG4105D7Q type ii secretion system LH89_16145 ENOG4107QHF type ii secretion system protein e LH89_16150 ENOG4108ZUW Major pilin subunit LH89_16155 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase LH89_16160 ENOG4105DRB nucleoside-specific channel-forming protein LH89_16165 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase LH89_16170 ENOG4106A72 regulatory protein AmpE LH89_16175 ENOG4105C85 amino acid LH89_16180 ENOG41073TP transcriptional regulator LH89_16185 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) LH89_16190 ENOG4107QSN dihydrolipoamide acetyltransferase LH89_16195 ENOG4107QN2 dihydrolipoyl dehydrogenase LH89_16205 ENOG4108PGP mmge prpd family protein LH89_16215 ENOG4107RNH Outer membrane receptor FepA LH89_16225 ENOG4107QIJ Aconitate hydratase 2 LH89_16230 ENOG4108ZIG UPF0231 protein LH89_16235 ENOG4105EE5 Membrane protein terC LH89_16240 ENOG4105CHR reductase LH89_16245 ENOG4105XEP YhcH YjgK YiaL family protein LH89_16260 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) LH89_16265 ENOG4105C0A alcohol dehydrogenase LH89_16270 ENOG4107S2N Type III effector Hrp-dependent LH89_16275 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) LH89_16280 ENOG4105MVE transcriptional regulator LH89_16290 ENOG4108URH decarboxylase LH89_16295 ENOG4107QP2 Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) (By similarity) LH89_16320 ENOG4105EFA 4-hydroxyphenylacetate LH89_16325 ENOG4105DSE periplasmic solute binding protein LH89_16330 ENOG4105CC5 ABC transporter LH89_16335 ENOG4105DIK (ABC) transporter LH89_16345 ENOG41066FR extracellular solute-binding protein LH89_16355 ENOG4105RD7 BadF BadG BcrA BcrD LH89_16375 ENOG4105F5H Glycosyl Hydrolase Family 88 LH89_16380 ENOG4108IJ9 (ABC) transporter LH89_16390 ENOG4105DRS transport system, permease LH89_16395 ENOG4105ETE Transcriptional regulator (LacI family LH89_16495 ENOG4108MEJ flavin reductase domain protein LH89_16505 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) LH89_16510 ENOG4108YXI Secondary thiamine-phosphate synthase enzyme LH89_16515 ENOG4105BZU Histidine kinase LH89_16520 ENOG4105BZU Histidine kinase LH89_16525 ENOG4105C8Q Methyl-accepting chemotaxis LH89_16530 ENOG4107SV5 CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. May be involved in the integration of spacer DNA into the CRISPR cassette (By similarity) LH89_16535 ENOG4107IIZ CRISPR-associated helicase, Cas3 LH89_16540 ENOG4105ENG CRISPR-associated protein, Csy1 family LH89_16545 ENOG4105DZX CRISPR-associated protein, Csy2 family LH89_16550 ENOG4105M6W Crispr-associated protein, Csy3 family LH89_16555 ENOG4108Y1S CRISPR-associated protein, Csy4 family LH89_16560 ENOG4105CGF Aromatic amino acid aminotransferase LH89_16570 ENOG4108XM1 transcriptional regulator AsnC family LH89_16580 ENOG4105C85 amino acid LH89_16585 ENOG4105F87 Dehydratase LH89_16595 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) LH89_16600 ENOG4105CDU Replicative dna helicase LH89_16605 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein LH89_16610 ENOG4105JZI cytochrome P450 LH89_16620 ENOG4105P4Z Phage shock protein G LH89_16625 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) LH89_16650 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) LH89_16655 ENOG4105E0C molybdate abc transporter LH89_16665 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) LH89_16670 ENOG4105RQF LysR family Transcriptional regulator LH89_16675 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) LH89_16680 ENOG4105DDV Transcriptional regulator (LacI family LH89_16685 ENOG4105VCP PTS System LH89_16690 ENOG4105CK1 PTS System LH89_16695 ENOG4105CS2 ec 3.2.1.21 LH89_16700 ENOG4105VZJ PTS System LH89_16705 ENOG4105C6F GntR Family Transcriptional Regulator LH89_16715 ENOG41060NJ transcriptional regulator LH89_16725 ENOG4105CID antiterminator LH89_16735 ENOG4105CS2 ec 3.2.1.21 LH89_16740 ENOG4105CS2 ec 3.2.1.21 LH89_16745 ENOG4105CEY Amp-dependent synthetase and ligase LH89_16750 ENOG4108J8Q Catalyzes the facilitated diffusion of 2-acyl-glycero-3- phosphoethanolamine (2-acyl-GPE) into the cell (By similarity) LH89_16755 ENOG4107YB6 acetyltransferase, (GNAT) family LH89_16765 ENOG4105CSA Coproporphyrinogen iii oxidase LH89_16770 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) LH89_16775 ENOG4105VZ9 UPF0235 protein LH89_16780 ENOG4108VIA integral membrane protein LH89_16785 ENOG4105II7 pyrroline-5-carboxylate reductase LH89_16790 ENOG4105DFA alanine racemase domain protein LH89_16795 ENOG4105CZX twitching motility protein LH89_16800 ENOG4105MZU cell filamentation protein LH89_16805 ENOG4105DZC cytosine deaminase LH89_16815 ENOG4105C8Q Methyl-accepting chemotaxis LH89_16820 ENOG4105KPV Transcriptional regulator LH89_16825 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) LH89_16830 ENOG4105C2N RNA methyltransferase TrmH family group 3 LH89_16845 ENOG4105C8Q Methyl-accepting chemotaxis LH89_16850 ENOG4108MXZ Esterase LH89_16855 ENOG4108ZDX Binds together with S18 to 16S ribosomal RNA (By similarity) LH89_16860 ENOG4108VDV Binds single-stranded DNA at the primosome assembly site (PAS) (By similarity) LH89_16865 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) LH89_16870 ENOG4105K9Q Binds to the 23S rRNA (By similarity) LH89_16880 ENOG4105FHY Opacity-associated protein A LH89_16885 ENOG4108V1T peptidylprolyl cis-trans isomerase LH89_16890 ENOG41062C6 Protein of unknown function (DUF2502) LH89_16895 ENOG4105FJH Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions (By similarity) LH89_16900 ENOG4107RNS bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase 3'-nucleotidase periplasmic LH89_16905 ENOG4108RNI 3'(2')5'-bisphosphate nucleotidase LH89_16910 ENOG41061GZ Protein of unknown function (DUF1107) LH89_16915 ENOG4105C37 (CBS) domain LH89_16920 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) LH89_16925 ENOG4105CFU surface antigen LH89_16930 ENOG4105MA0 exported protein LH89_16935 ENOG4108ZHD aig2 family LH89_16940 ENOG4105F0N pyrophosphate phospho-hydrolase LH89_16945 ENOG4105C8Q Methyl-accepting chemotaxis LH89_16950 ENOG4105K7Z Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity) LH89_16955 ENOG4107ZVW dihydroneopterin aldolase LH89_16960 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) LH89_16965 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate LH89_16970 ENOG4106MWK domain protein LH89_16975 ENOG4105I7R Adenylate cyclase LH89_16980 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) LH89_16985 ENOG4105DW0 Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity) LH89_16990 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) LH89_16995 ENOG4105VRT cytoplasmic protein LH89_17015 ENOG4107RHT methyl-accepting chemotaxis sensory transducer with Pas Pac sensor LH89_17020 ENOG4105CTX dehydratase LH89_17030 ENOG4105DJB Major Facilitator Superfamily LH89_17035 ENOG4105EQX glucarate dehydratase LH89_17040 ENOG4105EQX glucarate dehydratase LH89_17045 ENOG4105CNV Aldolase LH89_17050 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase LH89_17055 ENOG4105BZW Glycerate kinase LH89_17060 ENOG4105BZU Histidine kinase LH89_17065 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) LH89_17070 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) LH89_17075 ENOG4105DXN mazG family LH89_17080 ENOG4105C8D Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity) LH89_17085 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) LH89_17090 ENOG4105CT4 transporter LH89_17095 ENOG4105F5H Glycosyl Hydrolase Family 88 LH89_17105 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) LH89_17110 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase LH89_17130 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) LH89_17135 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) LH89_17140 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) LH89_17150 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) LH89_17155 ENOG4105C11 sulfate adenylyltransferase), subunit 2 LH89_17160 ENOG4105C3T may be the GTPase, regulating ATP sulfurylase activity (By similarity) LH89_17165 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) LH89_17170 ENOG4105N0Z inner membrane protein ygbE LH89_17175 ENOG4105XX3 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) LH89_17180 ENOG4105CE5 Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity) LH89_17185 ENOG4108UH8 Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity) LH89_17190 ENOG4106NZV Responsible for synthesis of pseudouridine from uracil- 13 in transfer RNAs (By similarity) LH89_17195 ENOG4105E26 Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins (By similarity) LH89_17200 ENOG4108K5P (LipO)protein LH89_17205 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) LH89_17210 ENOG4105C90 Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity) LH89_17215 ENOG4108R96 Methyltransferase, YaeB family LH89_17220 ENOG4108R8X outer membrane lipoprotein LH89_17225 ENOG4105D01 (LipO)protein LH89_17230 ENOG4108UMI ABC transporter, permease LH89_17240 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase LH89_17280 ENOG4105CSH Transporter LH89_17285 ENOG4105T42 (LipO)protein LH89_17290 ENOG4105JIM Phosphatidylserine synthase LH89_17295 ENOG4105CD5 CoA-binding domain protein LH89_17300 ENOG4106IUH DTW domain containing protein LH89_17305 ENOG4105K63 Thioredoxin LH89_17310 ENOG4105EIB trna rrna methyltransferase LH89_17315 ENOG4105C0R drug resistance transporter emrb qaca subfamily LH89_17320 ENOG4105CW7 secretion protein, HlyD family LH89_17325 ENOG4105NTK Transcriptional repressor Mpra LH89_17330 ENOG4105ZED uncharacterized protein ygaH LH89_17335 ENOG4108UMN azlc family LH89_17340 ENOG4105EQ0 Major Facilitator superfamily LH89_17345 ENOG4105GIJ Glycine betaine LH89_17350 ENOG4107U14 binding-protein-dependent transport systems inner membrane Component LH89_17355 ENOG4108IJ7 Glycine betaine LH89_17370 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease LH89_17380 ENOG410633P Hydantoin racemase LH89_17405 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) LH89_17420 ENOG4105DRP amino acid AbC transporter LH89_17425 ENOG4105E5Q amino acid AbC transporter LH89_17435 ENOG4105C5R Aminotransferase LH89_17450 ENOG4105CHM Aminotransferase LH89_17455 ENOG4107QY0 Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P) (By similarity) LH89_17460 ENOG4106YVY Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) (By similarity) LH89_17465 ENOG4108CAF Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway (By similarity) LH89_17470 ENOG4105C35 Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P) (By similarity) LH89_17475 ENOG4105CT5 Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate (By similarity) LH89_17480 ENOG4107QPN acyl-Coa dehydrogenase LH89_17485 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) LH89_17490 ENOG4105E7A Glutamine amidotransferase LH89_17495 ENOG4105F7V ErfK ybiS ycfS ynhG family protein LH89_17500 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) LH89_17505 ENOG4105CIN aminoacyl-histidine dipeptidase LH89_17515 ENOG4105DYA Acts on guanine, xanthine and to a lesser extent hypoxanthine (By similarity) LH89_17520 ENOG4105V1F Fermentation respiration switch protein LH89_17525 ENOG4108WS1 LH89_17530 ENOG4108KHX Diguanylate cyclase LH89_17535 ENOG4108UVK Binds to the sigma-S subunit of RNA polymerase, activating expression of sigma-S-regulated genes. Stimulates RNA polymerase holoenzyme formation and may bind to several other sigma factors, such as sigma-70 and sigma-32 (By similarity) LH89_17540 ENOG4105CGT Catalyzes the transfer of a phosphate group to glutamate to form glutamate 5-phosphate which rapidly cyclizes to 5- oxoproline (By similarity) LH89_17545 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) LH89_17555 ENOG4105DFP Integrase LH89_17615 ENOG4105UG9 Antitoxin of the YafO-YafN toxin-antitoxin system LH89_17625 ENOG41065DM this blockage is overcome by subsequent expression of antitoxin YafN. Overexpression causes cleavage of a number of mRNAs in a ribosome-dependent fashion. YafO binding to the 50S ribosomal subunit in the translation complex induces mRNA cleavage 3' to the region protected by the ribosome LH89_17635 ENOG4105CBZ Short-chain dehydrogenase reductase Sdr LH89_17645 ENOG4105K4U addiction module toxin, RelE StbE family LH89_17655 ENOG4105CK0 Membrane bOund o-acyl transferase mboat family protein LH89_17660 ENOG4108IQD Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Catalyzes an ATP-dependent two-step reaction where it forms a high energy D-alanyl AMP intermediate and transfers the alanyl residues from AMP to Dcp (By similarity) LH89_17670 ENOG4105EJC lysr family transcriptional regulator LH89_17680 ENOG4108K2R Glutathione-regulated potassium-efflux system ancillary protein LH89_17705 ENOG4108HRK Histidine kinase LH89_17710 ENOG4108NEV two component transcriptional regulator, LytTR family LH89_17715 ENOG4105D22 carbon starvation protein LH89_17720 ENOG4105VCD cytoplasmic protein LH89_17725 ENOG4105CKI cobalamin synthesis protein LH89_17735 ENOG4108K3Z AraC family transcriptional regulator LH89_17740 ENOG4108EKI Dehydrogenase LH89_17745 ENOG4105DJ4 phosphatidylserine decarboxylase LH89_17750 ENOG41062B0 ABC transporter, permease LH89_17755 ENOG4107R9N ABC transporter LH89_17760 ENOG4105C2J ABC transporter LH89_17765 ENOG4107R5U Periplasmic binding protein LacI transcriptional regulator LH89_17785 ENOG4105CH6 catalase LH89_17795 ENOG4105CHR reductase LH89_17805 ENOG410829K Lysine exporter protein (Lyse ygga) LH89_17810 ENOG4105CPW cytochrome b561 LH89_17830 ENOG4105C68 Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity) LH89_17835 ENOG4105Y3E Modulates RecA activity (By similarity) LH89_17840 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) LH89_17845 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) LH89_17870 ENOG4107VXZ Hydrolase LH89_17875 ENOG4105W39 Membrane LH89_17880 ENOG4105D9M gamma-glutamylcysteine synthetase LH89_17885 ENOG4106762 Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5- dihydroxy-2,3-pentadione (DPD) (By similarity) LH89_17890 ENOG4106KVJ cytochrome C assembly protein LH89_17895 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY LH89_17900 ENOG4105K5M 30s ribosomal protein S16 LH89_17905 ENOG4108ZR6 An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity) LH89_17910 ENOG4105D6X Specifically methylates guanosine-37 in various tRNAs (By similarity) LH89_17915 ENOG4108YY1 This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity) LH89_17935 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) LH89_17940 ENOG4105EHE chorismate mutase- prephenate dehydrogenase LH89_17950 ENOG4108WPH sigma 54 modulation protein ribosomal protein S30EA LH89_17955 ENOG4106SNF Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane LH89_17960 ENOG4105C34 Pseudouridine synthase LH89_17965 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase LH89_17970 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit LH89_18000 ENOG4107NA1 Endonuclease Exonuclease phosphatase LH89_18005 ENOG4105E9H Lytic Murein transglycosylase LH89_18010 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) LH89_18015 ENOG4105D1A Methyltransferase LH89_18020 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) LH89_18025 ENOG4107RZZ dna polymerase iii epsilon subunit LH89_18035 ENOG4107R25 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) LH89_18040 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) LH89_18045 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) LH89_18055 ENOG4105FDS Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine (By similarity) LH89_18060 ENOG4105CCX Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM), which serves as an aminopropyl donor (By similarity) LH89_18065 ENOG4108ZRK uncharacterized protein yacC LH89_18090 ENOG4108UGV hypoxanthine phosphoribosyltransferase LH89_18095 ENOG41077A9 carbonic anhydrase LH89_18100 ENOG4105DA5 (ABC) transporter LH89_18105 ENOG4105E3A (ABC) transporter LH89_18110 ENOG4108Z2X Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine (By similarity) LH89_18115 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) LH89_18120 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) LH89_18125 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase LH89_18130 ENOG4105DJ0 Poly(A) Polymerase LH89_18135 ENOG4106F3G Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity) LH89_18140 ENOG4108V7X Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters LH89_18145 ENOG4105PW4 Sugar fermentation stimulation protein homolog LH89_18150 ENOG4107XID 2'-5' rna ligase LH89_18155 ENOG4105CQ7 ATP-dependent helicase LH89_18160 ENOG4105BZ4 penicillin-binding protein LH89_18165 ENOG4105E0A ABC, transporter LH89_18170 ENOG4105J76 Periplasmic binding protein LH89_18175 ENOG4105S6R Iron-hydroxamate transporter permease subunit LH89_18195 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) LH89_18200 ENOG4105DUF Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity) LH89_18205 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein LH89_18210 ENOG4105C0H protease LH89_18215 ENOG4108IXP Carbohydrate diacid transcriptional activator CdaR LH89_18220 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein LH89_18225 ENOG4108I5D sulfate abc transporter LH89_18230 ENOG4105ECW sulfate abc transporter LH89_18235 ENOG4108IJ6 ABC transporter LH89_18265 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) LH89_18280 ENOG4105D5S Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity) LH89_18285 ENOG4108VKA Acts as a radical domain for damaged PFL and possibly other radical proteins (By similarity) LH89_18290 ENOG4105C1J atp-dependent rna helicase LH89_18295 ENOG4107S47 Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC) (By similarity) LH89_18300 ENOG4108IYU L-aspartate oxidase LH89_18315 ENOG4105VQK sigma E regulatory protein, MucB RseB LH89_18320 ENOG4105WMJ Positive regulator of sigma E, RseC MucC LH89_18330 ENOG4105C4S Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity) LH89_18335 ENOG4105C3F Signal peptidase i LH89_18340 ENOG4108ZBM Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity) LH89_18345 ENOG4105CWT An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity) LH89_18350 ENOG41071DT Involved in DNA repair and RecF pathway recombination (By similarity) LH89_18355 ENOG4105CSZ Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity) LH89_18360 ENOG4105KJV Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) LH89_18365 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding LH89_18370 ENOG4105CMB EAL domain-containing protein LH89_18375 ENOG4105BZU Histidine kinase LH89_18380 ENOG4107QZV Type I secretion membrane fusion protein LH89_18405 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate LH89_18410 ENOG4105HYY HAD superfamily (Subfamily IF) hydrolase, YfhB LH89_18415 ENOG4108Z6B deaminase LH89_18420 ENOG4105CHQ Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella (By similarity) LH89_18425 ENOG4107QIK phosphoribosylformylglycinamidine synthase LH89_18430 ENOG4107WP9 Histidine kinase LH89_18435 ENOG4108SKK alpha helix protein LH89_18440 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family LH89_18445 ENOG4108YZA Nitrogen regulatory protein pii LH89_18450 ENOG4105NBR Pectinesterase LH89_18470 ENOG4105DBA pectate lyase LH89_18475 ENOG4108EGH Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) LH89_18480 ENOG4105C65 Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity) LH89_18485 ENOG4105D8G Major Facilitator superfamily LH89_18490 ENOG41065CD Exported protein LH89_18495 ENOG4105D7X high-affinity nickel-transporter LH89_18505 ENOG4105E0A ABC, transporter LH89_18510 ENOG4105EHG Permease protein LH89_18525 ENOG4105CVS RNA methyltransferase TrmH family, group 1 LH89_18530 ENOG4108ZF1 Transcriptional regulator, BadM Rrf2 family LH89_18540 ENOG4107XTC May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins LH89_18545 ENOG4108Z4V iron-sulfur cluster assembly LH89_18550 ENOG4108SWN Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA (By similarity) LH89_18555 ENOG4105C9I Chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB LH89_18560 ENOG4108ZIT Ferredoxin, 2FE-2S LH89_18565 ENOG4105WVQ Fe-S assembly protein IscX LH89_18570 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) LH89_18575 ENOG4105YYA enhanced serine sensitivity protein SseB LH89_18580 ENOG4105KHC sulfurtransferase LH89_18585 ENOG4108UGX Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity) LH89_18590 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs LH89_18600 ENOG4105HSZ Cytoskeletal protein that is involved in cell-shape control through regulation of the length of the long axis (By similarity) LH89_18605 ENOG4105C4E Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity) LH89_18610 ENOG4105CUT histidyl-tRNA synthetase LH89_18615 ENOG4105N21 Membrane LH89_18620 ENOG4105CNE Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) LH89_18625 ENOG4105DKZ GTPase that plays an essential role in the late steps of ribosome biogenesis (By similarity) LH89_18640 ENOG4105D4Y metalloprotease LH89_18645 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) LH89_18650 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) LH89_18655 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) LH89_18665 ENOG4105EJC lysr family transcriptional regulator LH89_18670 ENOG4105F27 Major Facilitator LH89_18685 ENOG4105CF7 AraC family transcriptional regulator LH89_18695 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase LH89_18700 ENOG4105JQN Transcriptional regulator LH89_18705 ENOG4105RKW reductase (By LH89_18740 ENOG4105CBP Major Facilitator LH89_18760 ENOG4105C2C drug resistance transporter, Bcr CflA LH89_18765 ENOG4105C87 Aminotransferase class I and II LH89_18770 ENOG4105C4U 4-methyl-5-beta-hydroxyethylthiazole kinase LH89_18775 ENOG4105DWF phosphomethylpyrimidine kinase LH89_18780 ENOG4108VY7 phosphate-starvation-inducible protein PsiE LH89_18785 ENOG4105CFP Peptidase U32 LH89_18790 ENOG4105CHF Glutathione S-transferase LH89_18795 ENOG4105E3W Two component transcriptional regulator (Winged helix family LH89_18800 ENOG4105EB3 Histidine kinase LH89_18805 ENOG4105C0R drug resistance transporter emrb qaca subfamily LH89_18810 ENOG4105BZS acriflavin resistance protein LH89_18815 ENOG4105BZS acriflavin resistance protein LH89_18820 ENOG4105ENT Efflux transporter rnd family, mfp subunit LH89_18825 ENOG4105D9N nucleoside LH89_18830 ENOG4105CPC Aldo Keto reductase LH89_18860 ENOG4105UYK outer membrane protein a LH89_18865 ENOG4108ZD2 Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1 1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division (By similarity) LH89_18870 ENOG4108RZ1 DNA transformation protein LH89_18875 ENOG4105EM2 membrane LH89_18880 ENOG410901E Membrane LH89_18885 ENOG41088T4 Helicase IV LH89_18890 ENOG4108Z5K methylglyoxal synthase LH89_18900 ENOG4105K4P CoA-binding domain protein LH89_18905 ENOG4105GSS Involved in the degradation of certain denaturated proteins, including DnaA, during heat shock stress (By similarity) LH89_18910 ENOG4105VSY K01512 acylphosphatase EC 3.6.1.7 LH89_18915 ENOG4108Z0T Part of a sulfur-relay system (By similarity) LH89_18920 ENOG4108MN8 Membrane LH89_18935 ENOG4105M0C cytoplasmic protein LH89_18940 ENOG4108U51 Universal stress protein LH89_18945 ENOG4105KSC Transcriptional regulator, TraR DksA family LH89_18955 ENOG4105C9X ppx gppa phosphatase LH89_18960 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) LH89_18970 ENOG4105E2Z phosphate ABC transporter (Permease LH89_18975 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) LH89_18995 ENOG4105EJQ L-serine dehydratase LH89_19000 ENOG4105C44 Serine transporter LH89_19005 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit LH89_19010 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) LH89_19015 ENOG4105F10 Catalyzes the hydrolysis of the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1- phosphate (lipid X) and UMP (By similarity) LH89_19020 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) LH89_19030 ENOG4105C8N cysteinyl-tRNA synthetase LH89_19035 ENOG4105WQ3 Rna-binding protein LH89_19040 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) LH89_19045 ENOG4105C8Q Methyl-accepting chemotaxis LH89_19060 ENOG4105D6T Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L- homocysteine, respectively. Is also able to deaminate adenosine (By similarity) LH89_19065 ENOG41090B9 response to stress LH89_19090 ENOG4105C84 Histidine ammonia-lyase LH89_19095 ENOG4106YYS transcriptional regulatory protein LH89_19100 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism LH89_19110 ENOG4107QIJ Aconitate hydratase 2 LH89_19115 ENOG4105CZE histidine utilization repressor LH89_19145 ENOG4105C84 Histidine ammonia-lyase LH89_19150 ENOG4105CGP Urocanate hydratase LH89_19175 ENOG4108E16 pectate lyase LH89_19195 ENOG4107FKK extracellular solute-binding protein family 1 LH89_19205 ENOG4105EG2 ABC transporter, permease LH89_19215 ENOG4105C4C beta-galactosidase LH89_19220 ENOG4105CI1 PTS System LH89_19225 ENOG4108KDD Involved in the transport of maltose and maltodextrins (By similarity) LH89_19230 ENOG4105ETE Transcriptional regulator (LacI family LH89_19235 ENOG4105C5Q Transcriptional regulator LH89_19250 ENOG4107QZF nitrite reductase NADPH large subunit LH89_19260 ENOG4105EZE Cupin 4 family protein LH89_19280 ENOG410642W LysR family Transcriptional regulator LH89_19290 ENOG4105EGS Mechanosensitive ion channel LH89_19295 ENOG4105F0I Aminotransferase LH89_19300 ENOG4105CHM Aminotransferase LH89_19305 ENOG4105XQF Lipoprotein LH89_19310 ENOG4105YGF General secretion pathway protein LH89_19315 ENOG4108XKW General secretion pathway protein C LH89_19320 ENOG4105GVR general secretion pathway protein D LH89_19325 ENOG4107QHF type ii secretion system protein e LH89_19385 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase LH89_19390 ENOG4105KA0 thioesterase Superfamily protein LH89_19395 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase LH89_19400 ENOG4105WQI isochorismatase LH89_19405 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase LH89_19410 ENOG4105E4F Isochorismate synthase LH89_19415 ENOG4105E0K tonB-dependent siderophore receptor LH89_19420 ENOG4105E93 esterase LH89_19435 ENOG4105E0A ABC, transporter LH89_19440 ENOG4105TVJ transport system, permease LH89_19445 ENOG4105DQ5 transport system permease protein LH89_19455 ENOG4105PEC Iron-enterobactin transporter periplasmic binding protein LH89_19470 ENOG4105CUR 5'-nucleotidase, lipoprotein e(p4) family LH89_19485 ENOG410903C (LipO)protein LH89_19490 ENOG4105DWT malate dehydrogenase (quinone) LH89_19495 ENOG4105CKF membrane protein involved in aromatic hydrocarbon degradation LH89_19500 ENOG4105KZW UPF0381 protein LH89_19505 ENOG4105CHU acetyl-coa acetyltransferase LH89_19510 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase LH89_19515 ENOG4108BY2 phosphohistidine phosphatase LH89_19520 ENOG4108DG9 Smr protein MutS2 LH89_19525 ENOG4105C76 Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity) LH89_19530 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase LH89_19535 ENOG4105HPZ Involved in the removal of murein from the sacculus. May also facilitate integration of nascent murein strands into the sacculus by cleaving the peptide bonds between neighboring strands in mature murein (By similarity) LH89_19540 ENOG4105EJ9 Membrane LH89_19545 ENOG4108BPE -transporting atpase LH89_19550 ENOG4105MH2 YfcL protein LH89_19575 ENOG4108ZHJ Organic hydroperoxide resistance protein LH89_19595 ENOG4105CWG Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity) LH89_19600 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) LH89_19605 ENOG4106WZ1 flagella biosynthesis regulator LH89_19635 ENOG4105CJ0 Catalyzes the oxidation of erythronate-4-phosphate to 3- hydroxy-2-oxo-4-phosphonooxybutanoate (By similarity) LH89_19640 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) LH89_19645 ENOG4105DI7 Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity) LH89_19650 ENOG4105DQR SNARE associated Golgi LH89_19655 ENOG4107QTG Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity) LH89_19660 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase LH89_19665 ENOG4108S3P Sporulation domain protein LH89_19670 ENOG4105E96 Colicin v production protein LH89_19675 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase LH89_19680 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase LH89_19685 ENOG4105E89 ABC transporter LH89_19690 ENOG4105DSP amino acid AbC transporter LH89_19695 ENOG4106YG3 ABC transporter LH89_19700 ENOG4108JEH abc transporter atp-binding protein LH89_19705 ENOG4105ECP epimerase LH89_19710 ENOG4105CYM Glutathione S-transferase LH89_19715 ENOG4108RE9 Phosphodiesterase LH89_19725 ENOG4105C6K Malic enzyme LH89_19730 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) LH89_19735 ENOG4105PQ6 UPF0208 membrane protein LH89_19740 ENOG4105XWI UPF0304 protein LH89_19745 ENOG4105EVE HAD-superfamily hydrolase subfamily IA variant 3 LH89_19750 ENOG4107QWE )-transporter LH89_19755 ENOG4105DK2 UPF0207 protein LH89_19760 ENOG4105CHM Aminotransferase LH89_19765 ENOG4107NQ8 LysR family Transcriptional regulator LH89_19770 ENOG4105KWU NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain LH89_19775 ENOG4105ES3 NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) LH89_19780 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) LH89_19785 ENOG4105GKE subunit e LH89_19790 ENOG4107QIZ NADH dehydrogenase LH89_19795 ENOG4107R0R NADH dehydrogenase subunit g LH89_19800 ENOG4105CMZ NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity) LH89_19805 ENOG4105P3U NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) LH89_19810 ENOG4107UFS subunit j LH89_19815 ENOG41080EA NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) LH89_19820 ENOG4105D65 subunit l LH89_19825 ENOG4105C8S subunit m LH89_19830 ENOG4105CNR NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) LH89_19835 ENOG4107STQ Multicopper oxidase LH89_19845 ENOG4105JAB phenazine biosynthesis protein, phzf family LH89_19850 ENOG4105C5H ABC transporter LH89_19855 ENOG4105E3S small subunit LH89_19860 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein LH89_19865 ENOG4105CJ5 hydrogenase 2 b cytochrome subunit LH89_19870 ENOG4105DPX Hydrogenase, large subunit LH89_19875 ENOG4108USZ hydrogenase LH89_19880 ENOG4108WGS hydrogenase 2-specific chaperone LH89_19885 ENOG4105WMM Probably plays a role in a hydrogenase nickel cofactor insertion step (By similarity) LH89_19895 ENOG41082MF Hydrogenase assembly chaperone hypC hupF LH89_19900 ENOG4105CQS hydrogenase expression formation protein HypD LH89_19905 ENOG4105C45 hydrogenase expression formation protein (HypE) LH89_19910 ENOG4105C8H hydrogenase maturation protein Hypf LH89_19915 ENOG4105GSJ Inner membrane protein ylaC LH89_19920 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) LH89_19925 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family LH89_19930 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) LH89_19935 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein LH89_19940 ENOG4108MG3 formate dehydrogenase LH89_19945 ENOG4105CSP Major Facilitator Superfamily LH89_19950 ENOG4105F46 Necessary for formate dehydrogenase activity (By similarity) LH89_19960 ENOG4105C2C drug resistance transporter, Bcr CflA LH89_19965 ENOG41067SE Tetr family transcriptional regulator LH89_19970 ENOG4105C1P efflux transporter, rnd family, mfp subunit LH89_19975 ENOG4105BZS acriflavin resistance protein LH89_19980 ENOG4105ENJ RND efflux system, outer membrane lipoprotein LH89_19995 ENOG4105I5W Transporter LH89_20005 ENOG4105D7T ABC transporter LH89_20010 ENOG4107QZF nitrite reductase NADPH large subunit LH89_20020 ENOG4105CB8 Multifunctional enzyme that catalyzes the SAM-dependent methylation of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 and then position C-12 or C-18 to form trimethylpyrrocorphin 2. It also catalyzes the conversion of precorrin-2 into siroheme. This reaction consists of the NAD- dependent oxidation of precorrin-2 into sirohydrochlorin and its subsequent ferrochelation into siroheme (By similarity) LH89_20025 ENOG4108YYH Nadph-dependent fmn reductase LH89_20040 ENOG4105E89 ABC transporter LH89_20045 ENOG4105CHM Aminotransferase LH89_20050 ENOG4105ETT transcriptional Regulator, LysR family LH89_20055 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A LH89_20065 ENOG4105C8Q Methyl-accepting chemotaxis LH89_20075 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) LH89_20095 ENOG4105EB3 Histidine kinase LH89_20110 ENOG4105CMM transposase LH89_20160 ENOG4108EHY type IV secretion system LH89_20170 ENOG4108PCE TRANSFER protein LH89_20175 ENOG4108V42 Type IV secretion system protein VirB8 LH89_20230 ENOG4105KSC Transcriptional regulator, TraR DksA family LH89_20250 ENOG4105HVQ Regulatory factor of maltose metabolism LH89_20280 ENOG4105C85 amino acid LH89_20290 ENOG4105XVG cytoplasmic protein LH89_20295 ENOG4105WH1 Two component transcriptional regulator luxr family LH89_20300 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) LH89_20305 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase LH89_20340 ENOG4108Y7C Conserved Protein LH89_20350 ENOG41087BU transcriptional repressor DicA LH89_20375 ENOG4106CVF DNA replication protein LH89_20380 ENOG4105CDU Replicative dna helicase LH89_20450 ENOG4105NVB glycoside hydrolase, family 19 LH89_20625 ENOG4108J21 pectate lyase LH89_20630 ENOG4107QWR cellulase (EC 3.2.1.4) LH89_20640 ENOG4105UQX Mate efflux family protein LH89_20655 ENOG4105VZF DsrB protein LH89_20660 ENOG4105C8Q Methyl-accepting chemotaxis LH89_20665 ENOG4108I6A alcohol dehydrogenase LH89_20675 ENOG4105GEH Functions in complex with FlhC as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region. Activates expression of class 2 flagellar genes, including fliA, which is a flagellum-specific sigma factor that turns on the class 3 genes. Also regulates genes whose products function in a variety of physiological pathways (By similarity) LH89_20680 ENOG4106CIA Functions in complex with FlhD as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region LH89_20685 ENOG4107RD7 Flagellar Motor Protein, MotA LH89_20690 ENOG4105ER2 Ompa motb domain protein LH89_20695 ENOG4105CBS Chea signal transduction histidine kinase LH89_20700 ENOG4108V3W Chemotaxis protein, CheW LH89_20705 ENOG4105C8Q Methyl-accepting chemotaxis LH89_20715 ENOG4105BZU Histidine kinase LH89_20720 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) LH89_20725 ENOG4108VYJ response regulator receiver protein LH89_20730 ENOG4108KCC Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P) (By similarity) LH89_20735 ENOG4105D00 flagellar biosynthetic protein flhB LH89_20740 ENOG4105D7B Flagellar biosynthesis protein flha LH89_20755 ENOG4105M9M anti-sigma28 factor FlgM LH89_20760 ENOG4105CKS Flagella basal body P-ring formation protein flgA LH89_20765 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) LH89_20770 ENOG4108ZC9 flagellar basal-body rod protein flgc LH89_20775 ENOG4105W00 Flagellar hook capping protein LH89_20780 ENOG4105BZE flagellar hook protein, FlgE LH89_20785 ENOG4108KPB Flagellar basal-body rod protein FlgF LH89_20790 ENOG4105CGA flagellar basal-body rod protein FlgG LH89_20795 ENOG4107W7W Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) LH89_20800 ENOG4105D92 Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) LH89_20805 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj LH89_20810 ENOG4105E1Q flagellar hook-associated protein LH89_20815 ENOG4105DTJ flagellar hook-associated protein LH89_20820 ENOG4105D19 Role in flagellar biosynthesis (By similarity) LH89_20825 ENOG4105VS8 Flagellar biosynthetic protein fliq LH89_20830 ENOG4105CN7 Flagellar biosynthetic protein FliP LH89_20840 ENOG4105DD5 Flagellar motor switch protein LH89_20845 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) LH89_20850 ENOG4107ZI8 flagellar basal body-associated protein flil LH89_20855 ENOG4105WF4 Flagellar hook-length control protein LH89_20860 ENOG4105GSA Flagellar export protein flij LH89_20865 ENOG4108JIR Flagellum-specific ATP synthase LH89_20870 ENOG41090PJ Flagellar assembly protein LH89_20875 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) LH89_20880 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) LH89_20885 ENOG4105VQ0 flagellar hook-basal body complex protein fliE LH89_20895 ENOG4105MQ3 flagellar protein FliS LH89_20900 ENOG4105DTS flagellar hook-associated LH89_20905 ENOG4105I03 Flagellin LH89_20910 ENOG4106R49 Methyltransferase LH89_20925 ENOG4105DRI Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity) LH89_20935 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) LH89_20940 ENOG4108M9K flagella biosynthesis protein FliZ LH89_20945 ENOG4105D5M phosphate starvation-inducible protein LH89_20955 ENOG4105C8Q Methyl-accepting chemotaxis LH89_20975 ENOG4105C26 Dehydrogenase LH89_20985 ENOG4108RKI Necessary for the introduction of cis unsaturation into fatty acids. Catalyzes the dehydration of (3R)-3-hydroxydecanoyl- ACP to E-(2)-decenoyl-ACP and then its isomerization to Z-(3)- decenoyl-ACP. Can catalyze the dehydratase reaction for beta- hydroxyacyl-ACPs with saturated chain lengths up to 16 0, being most active on intermediate chain length (By similarity) LH89_20990 ENOG4105DAN ATP-dependent protease LH89_20995 ENOG4108R9Q Required for spatial organization of the terminus region of the chromosome (Ter macrodomain) during the cell cycle. Prevents early segregation of duplicated Ter macrodomains during cell division. Binds specifically to matS, which is a 13 bp signature motif repeated within the Ter macrodomain (By similarity) LH89_21000 ENOG410654E Membrane LH89_21010 ENOG4105C8Q Methyl-accepting chemotaxis LH89_21020 ENOG4105DJ9 glucan biosynthesis protein LH89_21025 ENOG4105C3A Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs) (By similarity) LH89_21030 ENOG4105C6X Major Facilitator LH89_21035 ENOG4105D1S lipid A biosynthesis LH89_21045 ENOG4105C72 UPF0176 protein LH89_21050 ENOG4108YYC ycei family LH89_21055 ENOG4105DS1 cytochrome b561 LH89_21060 ENOG4105PVA Biofilm formation regulatory protein BssS LH89_21065 ENOG4105MEA DNA damage-inducible protein i LH89_21070 ENOG4105EKE dihydroorotase LH89_21080 ENOG4107QQB Ribonuclease E LH89_21085 ENOG4105EI2 Pseudouridine synthase LH89_21090 ENOG4108UHJ MAF-like protein LH89_21095 ENOG4105FCQ metal-binding, possibly nucleic acid-binding protein LH89_21100 ENOG4105VGS 50s ribosomal protein l32 LH89_21105 ENOG4105C6B Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity) LH89_21110 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) LH89_21115 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase LH89_21120 ENOG4105CHR reductase LH89_21125 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) LH89_21130 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) LH89_21135 ENOG4105YAZ 4-amino-4-deoxychorismate lyase LH89_21140 ENOG4105HHA aminodeoxychorismate lyase LH89_21145 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) LH89_21150 ENOG4107QRG dna polymerase iii LH89_21155 ENOG4105F8V Hydrolase, tatD family LH89_21160 ENOG4105CI1 PTS System LH89_21165 ENOG4105DG4 malate L-lactate dehydrogenase LH89_21170 ENOG4105K59 histidine triad (HIT) protein LH89_21175 ENOG41090DQ Lipoprotein LH89_21180 ENOG4108WEF Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b) (By similarity) LH89_21185 ENOG4108RUM thiamine kinase LH89_21190 ENOG4107QPA Cleaves GlcNAc linked beta-1,4 to MurNAc tripeptides (By similarity) LH89_21200 ENOG4105CEP NADH dehydrogenase LH89_21205 ENOG4107MBR 17 kDa surface antigen LH89_21210 ENOG4105CQ4 Transcriptional regulator LH89_21215 ENOG4105DPW Major facilitator superfamily MFS_1 LH89_21225 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase LH89_21230 ENOG4105R8A Heat shock protein LH89_21235 ENOG4105BZU Histidine kinase LH89_21240 ENOG4108JA2 transcriptioN-repair coupling factor LH89_21245 ENOG4105D60 lipoprotein releasing system transmembrane protein LH89_21250 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) LH89_21255 ENOG4105D60 lipoprotein releasing system transmembrane protein LH89_21265 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) LH89_21275 ENOG4108ESU Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Involved in the translocation of the substrate across the membrane (By similarity) LH89_21280 ENOG4108V06 Glutathione peroxidase LH89_21285 ENOG41080WI Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system (By similarity) LH89_21290 ENOG4108QBX (LipO)protein LH89_21295 ENOG4107RMF Catalyzes both the ATP-dependent activation of exogenously supplied lipoate to lipoyl-AMP and the transfer of the activated lipoyl onto the lipoyl domains of lipoate-dependent enzymes (By similarity) LH89_21305 ENOG4105CNG UPF0061 protein LH89_21310 ENOG4105DIT ErfK YbiS YcfS YnhG family protein LH89_21315 ENOG4105EAQ (twin-arginine translocation) pathway signal LH89_21320 ENOG4105C5X domain protein LH89_21325 ENOG4105CGF Aromatic amino acid aminotransferase LH89_21340 ENOG4105C5S asparaginyl-tRNA synthetase LH89_21345 ENOG4107RH7 Nicotinate phosphoribosyltransferase LH89_21350 ENOG4105CD8 aminopeptidase N LH89_21355 ENOG4105E2Y ABC, transporter LH89_21360 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component LH89_21365 ENOG4105D4R Catalyzes the desulfonation of aliphatic sulfonates (By similarity) LH89_21370 ENOG4105GVF (ABC) transporter LH89_21375 ENOG4108UZX fmn reductase LH89_21380 ENOG4107QYT Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor (By similarity) LH89_21385 ENOG4108T7E Contributes to the efficiency of the cell division process by stabilizing the polymeric form of the cell division protein FtsZ. Acts by promoting interactions between FtsZ protofilaments and suppressing the GTPase activity of FtsZ (By similarity) LH89_21390 ENOG4105QVC MOSC domain-containing protein LH89_21395 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) LH89_21400 ENOG4105C5H ABC transporter LH89_21405 ENOG4105F1S paraquat-inducible protein a LH89_21410 ENOG4105DY2 Paraquat-inducible protein b LH89_21415 ENOG4108Q2G (LipO)protein LH89_21420 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) LH89_21425 ENOG4105CF9 Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation dephosphorylation (By similarity) LH89_21435 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) LH89_21440 ENOG4105IPI Membrane LH89_21445 ENOG4105CQB FAD linked oxidase domain protein LH89_21450 ENOG4105KA0 thioesterase Superfamily protein LH89_21460 ENOG4108Z4V iron-sulfur cluster assembly LH89_21465 ENOG4105DIW FeS assembly protein SUFB LH89_21470 ENOG4105C3K feS assembly ATPase SufC LH89_21475 ENOG4105JRK feS assembly protein SufD LH89_21480 ENOG4105C9B Cysteine desulfurase LH89_21485 ENOG4105P9C Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity) LH89_21490 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein LH89_21495 ENOG4105KMX major outer membrane lipoprotein LH89_21500 ENOG4105CA9 Pyruvate kinase LH89_21510 ENOG4105CC0 LysR family Transcriptional regulator LH89_21515 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase LH89_21520 ENOG4105FBW Monooxygenase LH89_21535 ENOG4105CWM branched-chain amino acid transport system II carrier protein LH89_21545 ENOG4105EW9 transcriptional regulator AsnC family LH89_21565 ENOG4108P68 Outer membrane porin LH89_21570 ENOG4105DYC esterase LH89_21580 ENOG4105C0W non-ribosomal peptide synthetase LH89_21600 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase LH89_21615 ENOG4105CEY Amp-dependent synthetase and ligase LH89_21630 ENOG4107QI1 Mate efflux family protein LH89_21640 ENOG4105IBP Cyclic peptide transporter LH89_21665 ENOG4107RSM transcriptional regulator LH89_21675 ENOG4105EGI Transcriptional regulator LH89_21680 ENOG4105VSH 4-oxalocrotonate tautomerase LH89_21710 ENOG4107QI1 Mate efflux family protein LH89_21715 ENOG4108R6K riboflavin synthase, subunit alpha LH89_21720 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase LH89_21725 ENOG4105ETE Transcriptional regulator (LacI family LH89_21735 ENOG4105K4H Nlp p60 protein LH89_21740 ENOG4105M2J Glutaredoxin LH89_21745 ENOG4105DH5 Responsible for the end-turnover of tRNA specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis (By similarity) LH89_21750 ENOG4108UYE Lactoylglutathione lyase LH89_21765 ENOG4108XTF Outer Membrane Lipoprotein LH89_21770 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) LH89_21775 ENOG410642K Lysozyme inhibitor LH89_21785 ENOG4105DA0 Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity) LH89_21790 ENOG4107XGF functions in a salvage pathway. Uses pyridoxamine (By similarity) LH89_21795 ENOG4108K3A Glutathione S-transferase LH89_21800 ENOG4107QM5 aconitate hydratase LH89_21805 ENOG4107QSI ABC, transporter LH89_21815 ENOG4105EYK Phosphatidylglycerophosphatase B LH89_21820 ENOG4105Q4A inner membrane protein yciS LH89_21825 ENOG4105CFV Tetratricopeptide repeat protein LH89_21840 ENOG4108ZJT translation initiation factor, Sui1 LH89_21845 ENOG41061RM osmotically inducible lipoprotein LH89_21850 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase LH89_21860 ENOG4105D22 carbon starvation protein LH89_21865 ENOG4107QM2 Aldo Keto reductase LH89_21870 ENOG4108IEC Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction (By similarity) LH89_21875 ENOG4107QKC Oxidoreductase alpha (molybdopterin) subunit LH89_21880 ENOG4107RSM transcriptional regulator LH89_21885 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH LH89_21890 ENOG4108JQ2 peptide transport system atp-binding protein LH89_21895 ENOG4108JQ3 Peptide ABC transporter ATP-binding protein LH89_21900 ENOG4108EU3 peptide transport system, permease LH89_21905 ENOG4108I5W peptide transport system, permease protein LH89_21910 ENOG4108HIY periplasmic LH89_21930 ENOG4105E51 psp operon transcriptional activator LH89_21935 ENOG41087YS Phage shock protein A LH89_21940 ENOG4105YYT phage shock protein B LH89_21945 ENOG4105FM1 phage shock protein C LH89_21955 ENOG4105CM6 amino acid regulated cytosolic protein LH89_21960 ENOG4106K28 UPF0283 membrane protein LH89_21980 ENOG4108MK9 spermidine N(1)-acetyltransferase LH89_21990 ENOG4108Z9I -acetyltransferase LH89_22010 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) LH89_22015 ENOG4105KXI murein peptide amidase A LH89_22020 ENOG4107QSI ABC, transporter LH89_22025 ENOG4107RX3 Mg2 transporter protein cora family protein LH89_22030 ENOG4105CB3 Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity) LH89_22070 ENOG4105C8Q Methyl-accepting chemotaxis LH89_22080 ENOG4105C5I Dehydrogenase LH89_22085 ENOG4107RHT methyl-accepting chemotaxis sensory transducer with Pas Pac sensor LH89_22090 ENOG4107H52 Dicarboxylate transport LH89_22100 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) LH89_22105 ENOG4105CQ7 ATP-dependent helicase LH89_22110 ENOG4105CVW peptidase s1 and s6 chymotrypsin hap LH89_22125 ENOG4105JJR Histidine kinase LH89_22130 ENOG4107EXC regulatoR LH89_22140 ENOG4105CHH sulfate transporter LH89_22145 ENOG4105EWV Sodium calcium exchanger membrane region LH89_22150 ENOG4108NH8 Cation transport protein LH89_22155 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component LH89_22160 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component LH89_22165 ENOG4105C3U ABC transporter LH89_22170 ENOG4107H6U ABC transporter LH89_22180 ENOG4105CMQ Chloride channel LH89_22185 ENOG4108R1E Serine threonine protein phosphatase 1 LH89_22195 ENOG4107RHT methyl-accepting chemotaxis sensory transducer with Pas Pac sensor LH89_22200 ENOG4105C8Q Methyl-accepting chemotaxis LH89_22210 ENOG4107QUY Guanine deaminase LH89_22215 ENOG4105ZTC transcriptional activator, Ogr delta LH89_22250 ENOG4105UZW Tail fiber assembly protein LH89_22260 ENOG4108C33 Resolvase LH89_22275 ENOG4105D2S major facilitator superfamily LH89_22280 ENOG4108DG9 Smr protein MutS2