locus-tag	class	description
LH89_00045	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
LH89_00055	COG2840	Smr protein MutS2
LH89_00120	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
LH89_00145	COG0840	transmembrane signaling receptor activity
LH89_00155	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
LH89_00155	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
LH89_00160	COG3008	intermembrane lipid transfer
LH89_00165	COG2995	paraquat-inducible protein a
LH89_00170	COG1956	GAF domain-containing protein
LH89_00175	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
LH89_00180	COG0793	Belongs to the peptidase S41A family
LH89_00195	COG2197	response regulator
LH89_00200	COG3850	Histidine kinase
LH89_00205	COG2223	nitrite transmembrane transporter activity
LH89_00210	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
LH89_00215	COG1140	nitrate reductase beta subunit
LH89_00220	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
LH89_00225	COG2181	nitrate reductase activity
LH89_00235	COG1454	alcohol dehydrogenase
LH89_00270	COG0583	DNA-binding transcription factor activity
LH89_00285	COG2076	Multidrug Resistance protein
LH89_00290	COG0583	DNA-binding transcription factor activity
LH89_00295	COG1064	alcohol dehydrogenase
LH89_00300	COG4221	oxidoreductase activity
LH89_00315	COG3842	ATPase activity
LH89_00325	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
LH89_00330	COG1012	belongs to the aldehyde dehydrogenase family
LH89_00340	COG1176	ABC-type spermidine putrescine transport system, permease component I
LH89_00360	COG4774	siderophore transport
LH89_00365	COG1349	DNA-binding transcription factor activity
LH89_00370	COG0483	inositol monophosphate 1-phosphatase activity
LH89_00375	COG2223	nitrite transmembrane transporter activity
LH89_00380	COG0561	phosphatase activity
LH89_00395	COG0765	amino acid transport
LH89_00400	COG0765	amino acid transport
LH89_00405	COG0626	cystathionine gamma-synthase activity
LH89_00425	COG0840	transmembrane signaling receptor activity
LH89_00430	COG0840	transmembrane signaling receptor activity
LH89_00440	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
LH89_00450	COG4792	protein secretion
LH89_00460	COG4794	Type iii secretion
LH89_00510	COG4585	Histidine kinase
LH89_00550	COG2951	lytic endotransglycosylase activity
LH89_00615	COG2831	hemolysin activation secretion protein
LH89_00675	COG2195	Cleaves the N-terminal amino acid of tripeptides
LH89_00680	COG2850	peptidyl-arginine hydroxylation
LH89_00695	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
LH89_00700	COG2915	High frequency lysogenization protein hflD homolog
LH89_00705	COG0482	sulfurtransferase activity
LH89_00715	COG1187	pseudouridine synthase activity
LH89_00720	COG0538	isocitrate dehydrogenase activity
LH89_00730	COG0501	Belongs to the peptidase M48B family
LH89_00735	COG0823	Involved in the tonB-independent uptake of proteins
LH89_00750	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
LH89_00755	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
LH89_00760	COG0291	Belongs to the bacterial ribosomal protein bL35 family
LH89_00770	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
LH89_00775	COG0072	phenylalanine-tRNA ligase activity
LH89_00775	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LH89_00780	COG0776	regulation of translation
LH89_00795	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
LH89_00800	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
LH89_00810	COG1988	membrane-bound metal-dependent
LH89_00815	COG2755	lipolytic protein G-D-S-L family
LH89_00815	COG0657	acetylesterase activity
LH89_00820	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
LH89_00830	COG3842	ATPase activity
LH89_00835	COG0395	ABC-type sugar transport system, permease component
LH89_00840	COG1175	transmembrane transport
LH89_00850	COG1028	Short-chain dehydrogenase reductase Sdr
LH89_00855	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
LH89_00860	COG1917	Cupin 2, conserved barrel domain protein
LH89_00875	COG1278	Cold shock
LH89_00880	COG2226	methyltransferase
LH89_00885	COG1971	Probably functions as a manganese efflux pump
LH89_00895	COG3716	PTS system mannose fructose sorbose family IID component
LH89_00900	COG3715	PTS system
LH89_00905	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LH89_00905	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
LH89_00910	COG1253	flavin adenine dinucleotide binding
LH89_00915	COG0840	transmembrane signaling receptor activity
LH89_00920	COG1760	l-serine dehydratase
LH89_00925	COG0494	nUDIX hydrolase
LH89_00940	COG0251	oxidation-reduction process
LH89_00945	COG1199	ATP-dependent helicase activity
LH89_00955	COG3065	identical protein binding
LH89_00960	COG0318	PFAM AMP-dependent synthetase and ligase
LH89_00965	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
LH89_00970	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
LH89_00975	COG2894	cell division
LH89_00980	COG0850	regulation of cytokinetic process
LH89_00990	COG0179	Fumarylacetoacetate (FAA) hydrolase
LH89_00995	COG2983	Belongs to the UPF0260 family
LH89_01000	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
LH89_01005	COG2186	Transcriptional regulator
LH89_01010	COG2719	SpoVR family
LH89_01015	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LH89_01090	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
LH89_01095	COG1074	ATP-dependent DNA helicase activity
LH89_01100	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
LH89_01105	COG3706	GGDEF domain
LH89_01130	COG0513	Belongs to the DEAD box helicase family
LH89_01140	COG0012	GTP binding
LH89_01145	COG0193	aminoacyl-tRNA hydrolase activity
LH89_01155	COG0583	DNA-binding transcription factor activity
LH89_01165	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
LH89_01170	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
LH89_01175	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
LH89_01180	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
LH89_01185	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
LH89_01190	COG2890	protein-(glutamine-N5) methyltransferase activity
LH89_01195	COG2912	Transglutaminase-like superfamily
LH89_01200	COG2877	3-deoxy-8-phosphooctulonate synthase activity
LH89_01210	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
LH89_01215	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
LH89_01225	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
LH89_01230	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
LH89_01235	COG0840	transmembrane signaling receptor activity
LH89_01250	COG0840	transmembrane signaling receptor activity
LH89_01260	COG3479	Phenolic acid decarboxylase
LH89_01275	COG3842	ATPase activity
LH89_01280	COG1175	transmembrane transport
LH89_01285	COG1176	ABC-type spermidine putrescine transport system, permease component I
LH89_01300	COG0584	glycerophosphoryl diester phosphodiesterase
LH89_01305	COG0483	inositol monophosphate 1-phosphatase activity
LH89_01310	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
LH89_01340	COG0702	epimerase
LH89_01385	COG3158	transport of potassium into the cell
LH89_01420	COG2995	paraquat-inducible protein a
LH89_01440	COG4305	rare lipoprotein A
LH89_01465	COG1215	transferase activity, transferring glycosyl groups
LH89_01470	COG2226	methyltransferase
LH89_01475	COG4221	oxidoreductase activity
LH89_01485	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
LH89_01505	COG1028	Short-chain dehydrogenase reductase Sdr
LH89_01520	COG2814	Major facilitator Superfamily
LH89_01535	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
LH89_01540	COG1940	carbohydrate kinase activity
LH89_01545	COG0583	DNA-binding transcription factor activity
LH89_01550	COG2814	Major facilitator Superfamily
LH89_01560	COG0114	fumarate hydratase activity
LH89_01565	COG1482	cell wall glycoprotein biosynthetic process
LH89_01570	COG5339	Protein conserved in bacteria
LH89_01580	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
LH89_01590	COG0385	Bile acid
LH89_01595	COG0673	inositol 2-dehydrogenase activity
LH89_01605	COG1172	Belongs to the binding-protein-dependent transport system permease family
LH89_01610	COG1129	ABC transporter
LH89_01615	COG1879	ABC-type sugar transport system periplasmic component
LH89_01620	COG1069	ribulokinase activity
LH89_01625	COG2160	L-arabinose isomerase activity
LH89_01635	COG4657	Part of a membrane complex involved in electron transport
LH89_01640	COG2878	Part of a membrane complex involved in electron transport
LH89_01645	COG4656	Part of a membrane complex involved in electron transport
LH89_01650	COG4658	electron transport chain
LH89_01655	COG4659	FMN binding
LH89_01665	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
LH89_01670	COG0583	DNA-binding transcription factor activity
LH89_01675	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
LH89_01690	COG0616	signal peptide processing
LH89_01695	COG1028	Short-chain dehydrogenase reductase Sdr
LH89_01700	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
LH89_01705	COG1187	pseudouridine synthase activity
LH89_01710	COG0009	L-threonylcarbamoyladenylate synthase
LH89_01715	COG0613	PHP domain protein
LH89_01725	COG0512	Glutamine amidotransferase of anthranilate synthase
LH89_01730	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
LH89_01740	COG0133	tryptophan synthase activity
LH89_01745	COG0159	tryptophan synthase activity
LH89_01750	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
LH89_01755	COG3047	cAMP biosynthetic process
LH89_01765	COG2917	probably involved in intracellular septation
LH89_01770	COG1607	acyl-coa hydrolase
LH89_01780	COG2350	Protein conserved in bacteria
LH89_01795	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
LH89_01810	COG0444	Belongs to the ABC transporter superfamily
LH89_01815	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LH89_01835	COG2095	MarC family integral membrane protein
LH89_01845	COG1454	alcohol dehydrogenase
LH89_01845	COG1012	belongs to the aldehyde dehydrogenase family
LH89_01850	COG1435	thymidine kinase activity
LH89_01860	COG1210	Utp--glucose-1-phosphate uridylyltransferase
LH89_01865	COG0745	RESPONSE REGULATOR receiver
LH89_01870	COG1752	Esterase of the alpha-beta hydrolase superfamily
LH89_01875	COG3012	SEC-C Motif Domain Protein
LH89_01880	COG0788	formyltetrahydrofolate deformylase activity
LH89_01890	COG2860	membrane
LH89_01895	COG0708	Exodeoxyribonuclease III
LH89_01910	COG0778	Nitroreductase
LH89_01915	COG0616	signal peptide processing
LH89_01920	COG0252	asparaginase activity
LH89_01925	COG1335	isochorismatase
LH89_01930	COG3139	Protein of unknown function (DUF1315)
LH89_01935	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
LH89_01950	COG0656	L-ascorbic acid biosynthetic process
LH89_01955	COG3713	MltA-interacting MipA family protein
LH89_01960	COG2766	serine protein kinase
LH89_01965	COG2718	Belongs to the UPF0229 family
LH89_01995	COG2261	transglycosylase associated protein
LH89_02035	COG2204	response regulator
LH89_02050	COG1528	Iron-storage protein
LH89_02055	COG1276	copper resistance
LH89_02075	COG1770	oligopeptidase
LH89_02080	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
LH89_02085	COG0800	Aldolase
LH89_02090	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
LH89_02095	COG1737	Transcriptional regulator
LH89_02100	COG0469	pyruvate kinase activity
LH89_02105	COG2963	transposase activity
LH89_02125	COG1560	Kdo2-lipid A biosynthetic process
LH89_02130	COG0739	heme binding
LH89_02135	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
LH89_02140	COG1121	(ABC) transporter
LH89_02145	COG1108	ABC-type Mn2 Zn2 transport systems permease components
LH89_02150	COG2255	four-way junction helicase activity
LH89_02155	COG0632	four-way junction helicase activity
LH89_02160	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
LH89_02165	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
LH89_02170	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
LH89_02175	COG0698	ribose 5-phosphate isomerase
LH89_02190	COG3395	kinase activity
LH89_02205	COG2390	Transcriptional regulator
LH89_02215	COG0217	transcriptional regulatory protein
LH89_02220	COG0494	nUDIX hydrolase
LH89_02225	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
LH89_02230	COG1801	Protein of unknown function DUF72
LH89_02235	COG3788	relative of glutathione S-transferase, MAPEG superfamily
LH89_02240	COG2226	methyltransferase
LH89_02245	COG0500	methyltransferase
LH89_02255	COG3142	Participates in the control of copper homeostasis
LH89_02260	COG3102	Protein conserved in bacteria
LH89_02265	COG0018	arginyl-trna synthetase
LH89_02360	COG0728	peptidoglycan biosynthetic process
LH89_02370	COG3132	Protein of unknown function, DUF480
LH89_02375	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
LH89_02380	COG0477	Major facilitator Superfamily
LH89_02385	COG2999	glutathione oxidoreductase activity
LH89_02395	COG3381	protein complex oligomerization
LH89_02400	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
LH89_02425	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
LH89_02435	COG1349	DNA-binding transcription factor activity
LH89_02445	COG0625	glutathione transferase activity
LH89_02455	COG0494	nUDIX hydrolase
LH89_02465	COG1733	regulation of RNA biosynthetic process
LH89_02470	COG2132	Multicopper oxidase
LH89_02475	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
LH89_02490	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
LH89_02490	COG2755	lipolytic protein G-D-S-L family
LH89_02515	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
LH89_02520	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
LH89_02525	COG3006	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Not required for mini-F plasmid partitioning. Probably acts via its interaction with MukB and MukE. Overexpression results in anucleate cells. It has a calcium binding activity
LH89_02530	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
LH89_02535	COG1434	Gram-negative-bacterium-type cell wall biogenesis
LH89_02540	COG3173	Aminoglycoside phosphotransferase
LH89_02550	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
LH89_02555	COG2835	tetraacyldisaccharide 4'-kinase activity
LH89_02560	COG1663	tetraacyldisaccharide 4'-kinase activity
LH89_02565	COG1132	(ABC) transporter
LH89_02570	COG0658	competence protein
LH89_02570	COG2333	competence protein COMEC
LH89_02580	COG2926	Belongs to the UPF0265 family
LH89_02585	COG2925	Exonuclease
LH89_02595	COG0531	amino acid
LH89_02600	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
LH89_02605	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
LH89_02610	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
LH89_02610	COG3697	Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase
LH89_02625	COG3052	prosthetic group binding
LH89_02630	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
LH89_02635	COG0179	Fumarylacetoacetate (FAA) hydrolase
LH89_02640	COG3493	citrate carrier protein
LH89_02655	COG0840	transmembrane signaling receptor activity
LH89_02660	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
LH89_02665	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
LH89_02670	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
LH89_02675	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
LH89_02680	COG0131	Imidazoleglycerol-phosphate dehydratase
LH89_02680	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
LH89_02685	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
LH89_02690	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
LH89_02695	COG0107	imidazoleglycerol-phosphate synthase activity
LH89_02700	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
LH89_02700	COG0140	phosphoribosyl-ATP diphosphatase activity
LH89_02715	COG0776	regulation of translation
LH89_02720	COG0539	negative regulation of cytoplasmic translation
LH89_02725	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
LH89_02730	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
LH89_02735	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
LH89_02740	COG1944	ATP diphosphatase activity
LH89_02745	COG2116	formate transmembrane transporter activity
LH89_02750	COG1882	Formate acetyltransferase
LH89_02755	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
LH89_02765	COG2814	Major facilitator Superfamily
LH89_02790	COG3381	protein complex oligomerization
LH89_02795	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
LH89_02800	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
LH89_02805	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
LH89_02810	COG1674	ftsk spoiiie
LH89_02810	COG3107	peptidoglycan biosynthetic process
LH89_02820	COG0492	ferredoxin-NADP+ reductase activity
LH89_02825	COG4988	ABC transporter
LH89_02830	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
LH89_02835	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
LH89_02840	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
LH89_02845	COG0542	response to heat
LH89_02850	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
LH89_02855	COG1278	Cold shock
LH89_02860	COG3593	DNA synthesis involved in DNA repair
LH89_02865	COG1151	hydroxylamine reductase activity
LH89_02870	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
LH89_02875	COG0702	epimerase
LH89_02880	COG3023	N-Acetylmuramoyl-L-alanine amidase
LH89_02885	COG0393	Putative heavy-metal-binding
LH89_02890	COG1126	abc transporter atp-binding protein
LH89_02900	COG4215	(ABC) transporter
LH89_02905	COG4160	amino acid transport
LH89_02910	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LH89_02920	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
LH89_02930	COG1177	transmembrane transport
LH89_02935	COG1176	ABC-type spermidine putrescine transport system, permease component I
LH89_02940	COG3842	ATPase activity
LH89_02945	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
LH89_02955	COG0189	ligase activity
LH89_02965	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
LH89_02975	COG2985	domain, Protein
LH89_02975	COG0569	domain protein
LH89_02980	COG1349	DNA-binding transcription factor activity
LH89_02985	COG1686	Belongs to the peptidase S11 family
LH89_02990	COG2267	carboxylic ester hydrolase activity
LH89_02995	COG2011	ABC-type metal ion transport system permease component
LH89_03000	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
LH89_03005	COG1464	Belongs to the NlpA lipoprotein family
LH89_03010	COG0625	glutathione transferase activity
LH89_03015	COG2133	pyrroloquinoline quinone binding
LH89_03020	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
LH89_03025	COG2949	membrane
LH89_03030	COG2311	Membrane
LH89_03035	COG0302	gtp cyclohydrolase
LH89_03040	COG0840	transmembrane signaling receptor activity
LH89_03050	COG0840	transmembrane signaling receptor activity
LH89_03065	COG0840	transmembrane signaling receptor activity
LH89_03075	COG0583	DNA-binding transcription factor activity
LH89_03100	COG0371	Dehydrogenase
LH89_03105	COG1129	ABC transporter
LH89_03110	COG1172	Belongs to the binding-protein-dependent transport system permease family
LH89_03120	COG0508	dehydrogenase complex catalyzes the overall conversion of
LH89_03135	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
LH89_03145	COG0833	amino acid
LH89_03150	COG0583	DNA-binding transcription factor activity
LH89_03155	COG2855	membrane
LH89_03160	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
LH89_03170	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
LH89_03170	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
LH89_03170	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
LH89_03175	COG1105	Belongs to the carbohydrate kinase PfkB family
LH89_03180	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
LH89_03180	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
LH89_03195	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
LH89_03200	COG0523	cobalamin synthesis protein
LH89_03205	COG0671	phosphoesterase, PA-phosphatase related
LH89_03210	COG0791	NLP P60 protein
LH89_03215	COG4166	transmembrane transport
LH89_03220	COG4174	ABC transporter (Permease)
LH89_03225	COG4239	(ABC) transporter, permease
LH89_03230	COG4172	Belongs to the ABC transporter superfamily
LH89_03240	COG2814	Major facilitator Superfamily
LH89_03245	COG1187	pseudouridine synthase activity
LH89_03260	COG1061	Type III restriction enzyme res subunit
LH89_03270	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
LH89_03275	COG2223	nitrite transmembrane transporter activity
LH89_03280	COG3279	Response regulator of the LytR AlgR family
LH89_03285	COG3275	phosphorelay sensor kinase activity
LH89_03290	COG3081	Nucleoid-associated protein
LH89_03295	COG3082	Protein of unknown function (DUF1414)
LH89_03345	COG1393	Belongs to the ArsC family
LH89_03360	COG2199	diguanylate cyclase activity
LH89_03360	COG2203	Gaf domain
LH89_03390	COG0444	Belongs to the ABC transporter superfamily
LH89_03395	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LH89_03400	COG0601	transmembrane transport
LH89_03420	COG3136	membrane protein required for alginate biosynthesis
LH89_03425	COG4677	pectinesterase activity
LH89_03450	COG1136	(ABC) transporter
LH89_03450	COG0577	efflux transmembrane transporter activity
LH89_03455	COG1136	(ABC) transporter
LH89_03470	COG0071	Belongs to the small heat shock protein (HSP20) family
LH89_03480	COG1984	allophanate hydrolase subunit 2
LH89_03490	COG0439	Biotin carboxylase
LH89_03510	COG2807	transmembrane transport
LH89_03515	COG1846	Transcriptional regulator
LH89_03520	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
LH89_03530	COG0783	Belongs to the Dps family
LH89_03535	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LH89_03540	COG0765	amino acid transport
LH89_03545	COG1126	abc transporter atp-binding protein
LH89_03575	COG0671	phosphoesterase, PA-phosphatase related
LH89_03590	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
LH89_03610	COG1472	Belongs to the glycosyl hydrolase 3 family
LH89_03615	COG0493	'glutamate synthase
LH89_03620	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
LH89_03620	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
LH89_03620	COG1013	pyruvate-flavodoxin oxidoreductase activity
LH89_03620	COG0674	pyruvate-flavodoxin oxidoreductase activity
LH89_03640	COG1686	Belongs to the peptidase S11 family
LH89_03645	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
LH89_03655	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
LH89_03660	COG0747	negative chemotaxis
LH89_03665	COG2195	Cleaves the N-terminal amino acid of tripeptides
LH89_03675	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LH89_03690	COG0584	glycerophosphoryl diester phosphodiesterase
LH89_03695	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LH89_03705	COG4608	Belongs to the ABC transporter superfamily
LH89_03710	COG0444	Belongs to the ABC transporter superfamily
LH89_03725	COG0697	spore germination
LH89_03730	COG0513	Belongs to the DEAD box helicase family
LH89_03735	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LH89_03740	COG1131	(ABC) transporter
LH89_03745	COG0842	Transport permease protein
LH89_03750	COG0842	Transport permease protein
LH89_03755	COG3568	Endonuclease Exonuclease Phosphatase
LH89_03760	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
LH89_03765	COG0670	Belongs to the BI1 family
LH89_03785	COG0314	molybdopterin synthase activity
LH89_03790	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
LH89_03800	COG0521	Mo-molybdopterin cofactor biosynthetic process
LH89_03805	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
LH89_03815	COG1294	oxidase, subunit
LH89_03820	COG1271	oxidase subunit
LH89_03830	COG0391	Required for morphogenesis under gluconeogenic growth conditions
LH89_03840	COG0556	nucleotide-excision repair
LH89_03855	COG2226	methyltransferase
LH89_03860	COG0156	8-amino-7-oxononanoate synthase activity
LH89_03865	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
LH89_03880	COG1380	Effector of murein hydrolase LrgA
LH89_03885	COG1346	cytolysis
LH89_03895	COG0295	cytidine deaminase activity
LH89_03900	COG0281	malic enzyme
LH89_03905	COG0303	'Molybdopterin
LH89_03910	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
LH89_03920	COG0457	Tetratricopeptide repeat
LH89_03920	COG0463	Glycosyl transferase, family 2
LH89_03930	COG0401	homolog of Blt101
LH89_03940	COG3228	Belongs to the MtfA family
LH89_03955	COG2207	Transcriptional regulator
LH89_03960	COG1979	alcohol dehydrogenase
LH89_03965	COG0803	Belongs to the bacterial solute-binding protein 9 family
LH89_03970	COG1121	(ABC) transporter
LH89_03975	COG1108	ABC-type Mn2 Zn2 transport systems permease components
LH89_03980	COG1108	ABC-type Mn2 Zn2 transport systems permease components
LH89_03990	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
LH89_04000	COG0679	Auxin Efflux Carrier
LH89_04035	COG0835	chemotaxis
LH89_04035	COG0784	Response regulator, receiver
LH89_04050	COG2964	Protein conserved in bacteria
LH89_04065	COG0174	glutamine synthetase
LH89_04085	COG0601	transmembrane transport
LH89_04090	COG1957	nucleoside hydrolase
LH89_04095	COG1957	nucleoside hydrolase
LH89_04100	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
LH89_04105	COG0747	negative chemotaxis
LH89_04115	COG2134	cdp-diacylglycerol pyrophosphatase
LH89_04130	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
LH89_04155	COG2011	ABC-type metal ion transport system permease component
LH89_04175	COG3416	Protein conserved in bacteria
LH89_04220	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
LH89_04225	COG2199	diguanylate cyclase activity
LH89_04240	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LH89_04260	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
LH89_04285	COG2211	Major facilitator Superfamily
LH89_04300	COG2864	formate dehydrogenase
LH89_04305	COG0437	4 iron, 4 sulfur cluster binding
LH89_04310	COG0243	molybdopterin cofactor binding
LH89_04310	COG3383	formate dehydrogenase (NAD+) activity
LH89_04320	COG1598	PFAM Uncharacterised protein family UPF0150
LH89_04325	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
LH89_04330	COG1120	ATPase activity
LH89_04335	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LH89_04340	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LH89_04345	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
LH89_04350	COG4264	IucA IucC family
LH89_04360	COG4264	IucA IucC family
LH89_04370	COG0019	diaminopimelate decarboxylase activity
LH89_04385	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
LH89_04390	COG3639	organic phosphonate transmembrane transporter activity
LH89_04405	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
LH89_04415	COG0583	DNA-binding transcription factor activity
LH89_04425	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
LH89_04430	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
LH89_04435	COG3454	Phosphonate metabolism
LH89_04440	COG4778	phosphonate C-P lyase system protein PhnL
LH89_04445	COG4107	phosphonate C-P lyase system protein PhnK
LH89_04450	COG3627	carbon phosphorus lyase activity
LH89_04455	COG3626	phosphonate metabolism
LH89_04460	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
LH89_04465	COG3624	Phosphonate C-P lyase system protein PhnG
LH89_04470	COG2188	Transcriptional regulator
LH89_04495	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
LH89_04500	COG1012	belongs to the aldehyde dehydrogenase family
LH89_04505	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LH89_04515	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
LH89_04525	COG2515	1-aminocyclopropane-1-carboxylate deaminase
LH89_04530	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
LH89_04540	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
LH89_04545	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
LH89_04550	COG0371	Dehydrogenase
LH89_04560	COG0625	glutathione transferase activity
LH89_04565	COG0625	glutathione transferase activity
LH89_04575	COG1434	Gram-negative-bacterium-type cell wall biogenesis
LH89_04580	COG1943	Transposase
LH89_04585	COG1301	dicarboxylic acid transport
LH89_04590	COG0583	DNA-binding transcription factor activity
LH89_04595	COG0697	spore germination
LH89_04610	COG0298	carbon dioxide binding
LH89_04615	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
LH89_04620	COG0651	ATP synthesis coupled electron transport
LH89_04625	COG0650	Formate hydrogenlyase subunit 4
LH89_04630	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
LH89_04635	COG4237	Hydrogenase 4 membrane
LH89_04640	COG0651	ATP synthesis coupled electron transport
LH89_04645	COG3261	NADH dehydrogenase
LH89_04645	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
LH89_04650	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LH89_04655	COG3260	NADH ubiquinone oxidoreductase 20
LH89_04665	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
LH89_04680	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
LH89_04685	COG3383	formate dehydrogenase (NAD+) activity
LH89_04695	COG1301	dicarboxylic acid transport
LH89_04700	COG0583	DNA-binding transcription factor activity
LH89_04710	COG1609	Transcriptional regulator
LH89_04715	COG3250	beta-galactosidase activity
LH89_04730	COG0765	amino acid transport
LH89_04735	COG0765	amino acid transport
LH89_04740	COG4221	oxidoreductase activity
LH89_04760	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
LH89_04765	COG1984	allophanate hydrolase subunit 2
LH89_04775	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LH89_04780	COG0697	spore germination
LH89_04785	COG2814	Major facilitator Superfamily
LH89_04805	COG3961	Belongs to the TPP enzyme family
LH89_04815	COG2814	Major facilitator Superfamily
LH89_04820	COG1566	PFAM secretion protein HlyD family protein
LH89_04825	COG1846	Transcriptional regulator
LH89_04830	COG1124	(ABC) transporter
LH89_04835	COG0444	Belongs to the ABC transporter superfamily
LH89_04840	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LH89_04845	COG0601	transmembrane transport
LH89_04850	COG0747	negative chemotaxis
LH89_04855	COG2890	protein-(glutamine-N5) methyltransferase activity
LH89_04865	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
LH89_04875	COG1285	pathogenesis
LH89_04880	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
LH89_04885	COG1116	anion transmembrane transporter activity
LH89_04890	COG4191	Histidine kinase
LH89_04895	COG4566	intracellular signal transduction
LH89_04905	COG1346	cytolysis
LH89_04915	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
LH89_04920	COG0247	lactate metabolic process
LH89_04925	COG1139	Iron-sulfur cluster binding protein
LH89_04930	COG1556	Lactate utilization protein
LH89_04945	COG0488	(ABC) transporter
LH89_04950	COG0730	response to heat
LH89_04975	COG0583	DNA-binding transcription factor activity
LH89_04985	COG0745	RESPONSE REGULATOR receiver
LH89_04990	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LH89_04995	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LH89_05045	COG1028	Short-chain dehydrogenase reductase Sdr
LH89_05050	COG2070	2-Nitropropane dioxygenase
LH89_05050	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
LH89_05055	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
LH89_05075	COG0577	efflux transmembrane transporter activity
LH89_05075	COG1136	(ABC) transporter
LH89_05080	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LH89_05090	COG0477	Major facilitator Superfamily
LH89_05095	COG3813	Protein conserved in bacteria
LH89_05115	COG3706	GGDEF domain
LH89_05115	COG2203	Gaf domain
LH89_05115	COG5001	Diguanylate cyclase
LH89_05115	COG4251	negative regulation of phosphorylation
LH89_05125	COG4948	Mandelate Racemase Muconate Lactonizing
LH89_05230	COG1473	amidohydrolase
LH89_05260	COG3209	COG3209 Rhs family protein
LH89_05315	COG3501	Rhs element vgr protein
LH89_05330	COG0443	Heat shock 70 kDa protein
LH89_05335	COG2214	Heat shock protein DnaJ domain protein
LH89_05345	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
LH89_05360	COG0444	Belongs to the ABC transporter superfamily
LH89_05385	COG2267	carboxylic ester hydrolase activity
LH89_05390	COG0783	Belongs to the Dps family
LH89_05395	COG2706	6-phosphogluconolactonase activity
LH89_05405	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
LH89_05410	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LH89_05415	COG4558	Periplasmic binding protein
LH89_05420	COG3720	iron ion transport
LH89_05440	COG2990	Protein conserved in bacteria
LH89_05460	COG3706	GGDEF domain
LH89_05480	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
LH89_05505	COG1210	Utp--glucose-1-phosphate uridylyltransferase
LH89_05535	COG2244	polysaccharide biosynthetic process
LH89_05540	COG1215	transferase activity, transferring glycosyl groups
LH89_05560	COG1088	dTDP-glucose 4,6-dehydratase activity
LH89_05615	COG1253	flavin adenine dinucleotide binding
LH89_05620	COG2982	Protein involved in outer membrane biogenesis
LH89_05625	COG0717	Belongs to the dCTP deaminase family
LH89_05630	COG0572	uridine kinase
LH89_05635	COG0489	protein tyrosine kinase activity
LH89_05640	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LH89_05640	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
LH89_05660	COG2706	6-phosphogluconolactonase activity
LH89_05665	COG0561	phosphatase activity
LH89_05670	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
LH89_05675	COG4149	molybdate abc transporter
LH89_05680	COG0725	ABC transporter, periplasmic molybdate-binding protein
LH89_05690	COG2005	Transcriptional regulator
LH89_05690	COG3585	molybdate ion transport
LH89_05695	COG1119	ATPase activity
LH89_05700	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
LH89_05705	COG1085	galactose-1-phosphate uridylyltransferase
LH89_05715	COG2017	converts alpha-aldose to the beta-anomer
LH89_05735	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LH89_05740	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LH89_05745	COG0588	phosphoglycerate mutase activity
LH89_05750	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
LH89_05755	COG1230	cation diffusion facilitator family transporter
LH89_05765	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
LH89_05770	COG1811	Na channel or pump
LH89_05785	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
LH89_05790	COG2885	chlorophyll binding
LH89_05795	COG0823	Involved in the tonB-independent uptake of proteins
LH89_05800	COG3064	Membrane
LH89_05805	COG0848	biopolymer transport protein
LH89_05810	COG0811	peptide transport
LH89_05815	COG0824	Thioesterase
LH89_05820	COG3790	cyd operon protein YbgE
LH89_05830	COG1294	oxidase, subunit
LH89_05835	COG1271	oxidase subunit
LH89_05840	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
LH89_05845	COG0045	succinate-CoA ligase (ADP-forming) activity
LH89_05850	COG0508	dehydrogenase complex catalyzes the overall conversion of
LH89_05855	COG0567	Dehydrogenase, E1 component
LH89_05860	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
LH89_05865	COG1053	succinate dehydrogenase
LH89_05870	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
LH89_05875	COG2009	succinate dehydrogenase
LH89_05880	COG0372	Belongs to the citrate synthase family
LH89_05885	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
LH89_05890	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
LH89_05895	COG1984	allophanate hydrolase subunit 2
LH89_05900	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
LH89_05905	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
LH89_05910	COG0415	Belongs to the DNA photolyase family
LH89_05915	COG3272	Protein of unknown function (DUF1722)
LH89_05930	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
LH89_05935	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
LH89_05940	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
LH89_05945	COG2205	protein histidine kinase activity
LH89_05950	COG0745	RESPONSE REGULATOR receiver
LH89_05960	COG0033	Phosphoglucomutase
LH89_05970	COG0596	Alpha beta hydrolase
LH89_05980	COG0840	transmembrane signaling receptor activity
LH89_05985	COG0716	FMN binding
LH89_05990	COG0735	belongs to the Fur family
LH89_05995	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
LH89_06000	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LH89_06000	COG2190	(PTS) system
LH89_06000	COG1263	PTS System
LH89_06005	COG0363	glucosamine-6-phosphate deaminase activity
LH89_06010	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
LH89_06015	COG1940	carbohydrate kinase activity
LH89_06015	COG1846	Transcriptional regulator
LH89_06020	COG0367	asparagine synthase
LH89_06060	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
LH89_06065	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
LH89_06070	COG1702	phosphate starvation-inducible protein PhoH
LH89_06075	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
LH89_06080	COG4535	Mg2 and Co2 transporter CorC
LH89_06085	COG0815	Transfers the fatty acyl group on membrane lipoproteins
LH89_06095	COG0765	amino acid transport
LH89_06100	COG0765	amino acid transport
LH89_06105	COG1126	abc transporter atp-binding protein
LH89_06110	COG2888	peptidyl-tyrosine sulfation
LH89_06115	COG0495	leucyl-tRNA aminoacylation
LH89_06120	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
LH89_06125	COG1466	dna polymerase III delta subunit
LH89_06130	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
LH89_06135	COG0799	negative regulation of ribosome biogenesis
LH89_06140	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
LH89_06145	COG0768	penicillin binding
LH89_06150	COG0772	Belongs to the SEDS family
LH89_06155	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
LH89_06160	COG1686	Belongs to the peptidase S11 family
LH89_06165	COG2921	Belongs to the UPF0250 family
LH89_06170	COG0321	lipoyl(octanoyl) transferase activity
LH89_06175	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
LH89_06180	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
LH89_06185	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
LH89_06190	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
LH89_06195	COG1278	Cold shock
LH89_06200	COG1794	racemase activity, acting on amino acids and derivatives
LH89_06205	COG1393	Belongs to the ArsC family
LH89_06210	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
LH89_06215	COG1876	peptidase activity
LH89_06225	COG0400	carboxylic ester hydrolase activity
LH89_06230	COG1444	tRNA N-acetyltransferase activity
LH89_06235	COG2707	UPF0756 membrane protein
LH89_06240	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
LH89_06245	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
LH89_06255	COG2716	regulation of RNA biosynthetic process
LH89_06260	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
LH89_06270	COG4783	chaperone-mediated protein folding
LH89_06275	COG1393	Belongs to the ArsC family
LH89_06280	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
LH89_06285	COG2233	PERMEase
LH89_06290	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
LH89_06295	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
LH89_06300	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
LH89_06330	COG0765	amino acid transport
LH89_06345	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
LH89_06350	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
LH89_06355	COG4181	ATPase activity
LH89_06360	COG2755	lipolytic protein G-D-S-L family
LH89_06365	COG0300	oxidoreductase activity
LH89_06370	COG3118	belongs to the thioredoxin family
LH89_06395	COG1441	menaquinone biosynthetic process
LH89_06405	COG0596	Alpha beta hydrolase
LH89_06410	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
LH89_06415	COG1169	isochorismate synthase
LH89_06420	COG2223	nitrite transmembrane transporter activity
LH89_06425	COG0642	Histidine kinase
LH89_06425	COG2198	Histidine kinase
LH89_06435	COG2205	protein histidine kinase activity
LH89_06435	COG0784	Response regulator, receiver
LH89_06445	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
LH89_06450	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
LH89_06460	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
LH89_06465	COG0330	HflC and HflK could
LH89_06470	COG1585	Membrane protein implicated in regulation of membrane protease activity
LH89_06480	COG2217	Heavy metal translocating P-type atpase
LH89_06485	COG3735	TraB family
LH89_06490	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
LH89_06500	COG0840	transmembrane signaling receptor activity
LH89_06510	COG0737	Belongs to the 5'-nucleotidase family
LH89_06515	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
LH89_06515	COG4651	solute:proton antiporter activity
LH89_06520	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
LH89_06525	COG0563	adenylate kinase activity
LH89_06530	COG0326	Molecular chaperone. Has ATPase activity
LH89_06535	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
LH89_06540	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
LH89_06550	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
LH89_06555	COG2832	Protein of unknown function (DUF454)
LH89_06575	COG1196	nuclear chromosome segregation
LH89_06575	COG3264	Mechanosensitive ion channel
LH89_06580	COG1309	transcriptional regulator
LH89_06585	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LH89_06590	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LH89_06595	COG0254	rRNA binding
LH89_06600	COG0257	Belongs to the bacterial ribosomal protein bL36 family
LH89_06615	COG3695	enzyme binding
LH89_06620	COG3126	Type III secretion system lipoprotein chaperone (YscW)
LH89_06625	COG1946	Acyl-CoA thioesterase
LH89_06630	COG0004	ammonium transporteR
LH89_06635	COG0347	Belongs to the P(II) protein family
LH89_06640	COG1132	(ABC) transporter
LH89_06645	COG1132	(ABC) transporter
LH89_06650	COG1522	sequence-specific DNA binding
LH89_06660	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
LH89_06665	COG1555	photosystem II stabilization
LH89_06670	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
LH89_06675	COG0776	regulation of translation
LH89_06680	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
LH89_06685	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
LH89_06690	COG0740	serine-type endopeptidase activity
LH89_06695	COG0544	peptidyl-prolyl cis-trans isomerase activity
LH89_06700	COG0271	Belongs to the BolA IbaG family
LH89_06705	COG3056	Lipoprotein
LH89_06710	COG2223	nitrite transmembrane transporter activity
LH89_06715	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
LH89_06720	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
LH89_06725	COG1845	cytochrome c oxidase, subunit III
LH89_06730	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
LH89_06735	COG0109	protoheme IX farnesyltransferase activity
LH89_06740	COG2814	Major facilitator Superfamily
LH89_06755	COG1666	GTP binding
LH89_06760	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
LH89_06765	COG0693	protein deglycase activity
LH89_06770	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
LH89_06770	COG0301	tRNA thio-modification
LH89_06775	COG1722	exodeoxyribonuclease VII activity
LH89_06785	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
LH89_06790	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
LH89_06795	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
LH89_06800	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
LH89_06805	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
LH89_06810	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
LH89_06810	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
LH89_06815	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
LH89_06820	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
LH89_06825	COG4238	major outer membrane lipoprotein
LH89_06830	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
LH89_06835	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
LH89_06840	COG1862	Preprotein translocase
LH89_06845	COG0343	queuine tRNA-ribosyltransferase activity
LH89_06850	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
LH89_06855	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
LH89_06860	COG0450	alkyl hydroperoxide reductase
LH89_06870	COG1114	Component of the transport system for branched-chain amino acids
LH89_06875	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
LH89_06885	COG5002	protein histidine kinase activity
LH89_06895	COG0420	3'-5' exonuclease activity
LH89_06900	COG0419	ATPase involved in DNA repair
LH89_06905	COG1940	carbohydrate kinase activity
LH89_06910	COG2974	May be involved in recombination
LH89_06915	COG0840	transmembrane signaling receptor activity
LH89_06920	COG3123	guanosine phosphorylase activity
LH89_06935	COG4615	Cyclic peptide transporter
LH89_06940	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
LH89_06955	COG0583	DNA-binding transcription factor activity
LH89_06980	COG0583	DNA-binding transcription factor activity
LH89_07005	COG3706	GGDEF domain
LH89_07010	COG2824	Alkylphosphonate utilization operon protein PhnA
LH89_07025	COG0546	phosphoglycolate phosphatase activity
LH89_07035	COG0583	DNA-binding transcription factor activity
LH89_07105	COG1881	PFAM PEBP family protein
LH89_07120	COG0778	Nitroreductase
LH89_07150	COG1733	regulation of RNA biosynthetic process
LH89_07165	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
LH89_07170	COG3015	lipoprotein NlpE involved in copper resistance
LH89_07175	COG4681	YaeQ
LH89_07185	COG4568	rho-dependent transcription termination
LH89_07190	COG0037	tRNA processing
LH89_07195	COG0346	lactoylglutathione lyase activity
LH89_07200	COG0825	malonyl-CoA metabolic process
LH89_07205	COG0587	DNA-directed DNA polymerase activity
LH89_07210	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
LH89_07215	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
LH89_07220	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
LH89_07225	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
LH89_07230	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
LH89_07235	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
LH89_07240	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
LH89_07245	COG0750	zinc metalloprotease
LH89_07250	COG0575	Belongs to the CDS family
LH89_07255	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
LH89_07260	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
LH89_07265	COG0233	cytoplasmic translational termination
LH89_07275	COG0528	UMP kinase activity
LH89_07280	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
LH89_07290	COG0024	Methionine aminopeptidase
LH89_07295	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
LH89_07300	COG2171	N-acyltransferase activity
LH89_07330	COG1611	Belongs to the LOG family
LH89_07335	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
LH89_07340	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
LH89_07345	COG2363	Small membrane protein
LH89_07350	COG0583	DNA-binding transcription factor activity
LH89_07360	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
LH89_07365	COG2166	iron-sulfur cluster assembly
LH89_07370	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
LH89_07380	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
LH89_07390	COG0456	acetyltransferase
LH89_07395	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
LH89_07410	COG0860	N-Acetylmuramoyl-L-alanine amidase
LH89_07415	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
LH89_07415	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
LH89_07420	COG1025	Belongs to the peptidase M16 family
LH89_07435	COG4795	General secretion pathway protein
LH89_07440	COG2165	general secretion pathway protein
LH89_07445	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
LH89_07450	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
LH89_07460	COG0494	nUDIX hydrolase
LH89_07465	COG3066	DNA modification
LH89_07470	COG0861	Integral membrane protein TerC family
LH89_07480	COG0667	Aldo Keto reductase
LH89_07505	COG3171	Protein conserved in bacteria
LH89_07510	COG0220	tRNA (guanine-N7-)-methyltransferase activity
LH89_07520	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
LH89_07525	COG0741	lytic transglycosylase activity
LH89_07535	COG1982	Orn Lys Arg decarboxylase major
LH89_07585	COG4221	oxidoreductase activity
LH89_07610	COG0534	Mate efflux family protein
LH89_07615	COG1028	Short-chain dehydrogenase reductase Sdr
LH89_07655	COG1136	(ABC) transporter
LH89_07655	COG0577	efflux transmembrane transporter activity
LH89_07665	COG1136	(ABC) transporter
LH89_07665	COG0577	efflux transmembrane transporter activity
LH89_07670	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
LH89_07710	COG1733	regulation of RNA biosynthetic process
LH89_07720	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LH89_07730	COG5002	protein histidine kinase activity
LH89_07735	COG0745	RESPONSE REGULATOR receiver
LH89_07775	COG2862	Uncharacterized protein family, UPF0114
LH89_07795	COG2904	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
LH89_07795	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
LH89_07800	COG0583	DNA-binding transcription factor activity
LH89_07805	COG0473	3-isopropylmalate dehydrogenase activity
LH89_07820	COG1653	transport
LH89_07840	COG1234	tRNA 3'-trailer cleavage
LH89_07845	COG1609	Transcriptional regulator
LH89_07870	COG0437	4 iron, 4 sulfur cluster binding
LH89_07875	COG3301	Polysulphide reductase, NrfD
LH89_07880	COG0477	Major facilitator Superfamily
LH89_07885	COG0431	NADPH-dependent FMN reductase
LH89_07885	COG3976	FMN-binding domain protein
LH89_07885	COG1053	succinate dehydrogenase
LH89_07890	COG1053	succinate dehydrogenase
LH89_07915	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
LH89_07915	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
LH89_07920	COG3604	Transcriptional regulator
LH89_07925	COG1773	rubredoxin
LH89_07925	COG0426	domain, Protein
LH89_07930	COG0446	pyridine nucleotide-disulphide oxidoreductase
LH89_07940	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
LH89_07950	COG0531	amino acid
LH89_07955	COG3115	cell septum assembly
LH89_07960	COG2981	High affinity, high specificity proton-dependent sulfate transporter, which mediates sulfate uptake. Provides the sulfur source for the cysteine synthesis pathway
LH89_07965	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
LH89_07970	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
LH89_07980	COG2190	(PTS) system
LH89_07985	COG2205	protein histidine kinase activity
LH89_07990	COG0745	RESPONSE REGULATOR receiver
LH89_07995	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LH89_08000	COG0577	efflux transmembrane transporter activity
LH89_08000	COG1136	(ABC) transporter
LH89_08010	COG2837	iron assimilation
LH89_08040	COG4178	(ABC) transporter
LH89_08045	COG0612	Peptidase, M16
LH89_08050	COG4771	TonB-dependent receptor
LH89_08055	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
LH89_08060	COG0456	acetyltransferase
LH89_08065	COG0408	coproporphyrinogen oxidase activity
LH89_08070	COG1671	Belongs to the UPF0178 family
LH89_08080	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
LH89_08085	COG0494	nUDIX hydrolase
LH89_08090	COG1914	H( )-stimulated, divalent metal cation uptake system
LH89_08095	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
LH89_08100	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
LH89_08105	COG0497	DNA recombination
LH89_08115	COG2914	Belongs to the UPF0125 (RnfH) family
LH89_08120	COG2867	negative regulation of translational initiation
LH89_08130	COG0582	viral genome integration into host DNA
LH89_08220	COG3846	protein secretion by the type IV secretion system
LH89_08230	COG3451	type IV secretory pathway VirB4
LH89_08245	COG4962	Type ii secretion system protein e
LH89_08265	COG0583	DNA-binding transcription factor activity
LH89_08270	COG3423	Transcriptional regulator
LH89_08285	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
LH89_08345	COG2963	transposase activity
LH89_08350	COG3547	Transposase (IS116 IS110 IS902 family)
LH89_08405	COG4948	Mandelate Racemase Muconate Lactonizing
LH89_08410	COG2271	Major facilitator Superfamily
LH89_08415	COG0583	DNA-binding transcription factor activity
LH89_08420	COG2951	lytic endotransglycosylase activity
LH89_08430	COG3718	enzyme involved in inositol metabolism
LH89_08440	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LH89_08450	COG1172	Belongs to the binding-protein-dependent transport system permease family
LH89_08460	COG1879	ABC-type sugar transport system periplasmic component
LH89_08465	COG0673	inositol 2-dehydrogenase activity
LH89_08470	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
LH89_08495	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
LH89_08500	COG3962	Belongs to the TPP enzyme family
LH89_08525	COG0583	DNA-binding transcription factor activity
LH89_08530	COG2814	Major facilitator Superfamily
LH89_08555	COG1181	Belongs to the D-alanine--D-alanine ligase family
LH89_08575	COG2211	Major facilitator Superfamily
LH89_08605	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LH89_08605	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
LH89_08605	COG1013	pyruvate-flavodoxin oxidoreductase activity
LH89_08605	COG0674	pyruvate-flavodoxin oxidoreductase activity
LH89_08610	COG1376	ErfK ybiS ycfS ynhG family protein
LH89_08615	COG1846	Transcriptional regulator
LH89_08625	COG2814	Major facilitator Superfamily
LH89_08630	COG0246	Mannitol dehydrogenase
LH89_08670	COG3712	iron ion homeostasis
LH89_08680	COG4608	Belongs to the ABC transporter superfamily
LH89_08685	COG0444	Belongs to the ABC transporter superfamily
LH89_08695	COG0601	transmembrane transport
LH89_08700	COG0747	negative chemotaxis
LH89_08705	COG4948	Mandelate Racemase Muconate Lactonizing
LH89_08725	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
LH89_08730	COG3162	membrane
LH89_08735	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
LH89_08740	COG0025	NhaP-type Na H and K H
LH89_08745	COG2252	PERMEase
LH89_08750	COG1560	Kdo2-lipid A biosynthetic process
LH89_08770	COG0395	ABC-type sugar transport system, permease component
LH89_08775	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
LH89_08790	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
LH89_08805	COG1733	regulation of RNA biosynthetic process
LH89_08835	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LH89_08890	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
LH89_08895	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
LH89_08900	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
LH89_08905	COG4974	Belongs to the 'phage' integrase family
LH89_08910	COG0477	Major facilitator Superfamily
LH89_08915	COG0716	FMN binding
LH89_08925	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
LH89_08930	COG0354	folic acid binding
LH89_08935	COG1272	protein, Hemolysin III
LH89_08945	COG1280	lysine exporter protein (LysE YggA)
LH89_08950	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
LH89_08950	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
LH89_08955	COG0509	glycine decarboxylation via glycine cleavage system
LH89_08960	COG0404	The glycine cleavage system catalyzes the degradation of glycine
LH89_08965	COG1454	alcohol dehydrogenase
LH89_09005	COG0583	DNA-binding transcription factor activity
LH89_09010	COG0667	Aldo Keto reductase
LH89_09015	COG2813	Specifically methylates the guanine in position
LH89_09020	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
LH89_09025	COG0456	acetyltransferase
LH89_09030	COG1595	DNA-templated transcription, initiation
LH89_09045	COG4178	(ABC) transporter
LH89_09050	COG0813	purine-nucleoside phosphorylase activity
LH89_09055	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
LH89_09065	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
LH89_09080	COG3153	acetyltransferase
LH89_09100	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LH89_09105	COG0513	Belongs to the DEAD box helicase family
LH89_09115	COG1185	polyribonucleotide nucleotidyltransferase activity
LH89_09125	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
LH89_09130	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
LH89_09135	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
LH89_09140	COG0195	Participates in both transcription termination and antitermination
LH89_09160	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
LH89_09165	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
LH89_09170	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
LH89_09175	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
LH89_09180	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
LH89_09185	COG1534	Rna-binding protein
LH89_09190	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
LH89_09195	COG2027	D-alanyl-D-alanine carboxypeptidase
LH89_09200	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
LH89_09205	COG0697	spore germination
LH89_09215	COG0261	This protein binds to 23S rRNA in the presence of protein L20
LH89_09220	COG0142	geranyltranstransferase activity
LH89_09240	COG1438	arginine binding
LH89_09245	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
LH89_09255	COG0358	DNA primase activity
LH89_09260	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
LH89_09280	COG0300	oxidoreductase activity
LH89_09285	COG0300	oxidoreductase activity
LH89_09290	COG0667	Aldo Keto reductase
LH89_09305	COG1053	succinate dehydrogenase
LH89_09315	COG1477	protein flavinylation
LH89_09320	COG3678	ATP-independent chaperone mediated protein folding
LH89_09330	COG2271	Major facilitator Superfamily
LH89_09340	COG2197	response regulator
LH89_09355	COG2813	Specifically methylates the guanine in position
LH89_09360	COG0861	Integral membrane protein TerC family
LH89_09370	COG2721	sulfolactate sulfo-lyase activity
LH89_09375	COG0246	Mannitol dehydrogenase
LH89_09380	COG1904	glucuronate isomerase
LH89_09385	COG2271	Major facilitator Superfamily
LH89_09395	COG0586	Pfam SNARE associated Golgi protein
LH89_09405	COG4575	ribosome binding
LH89_09410	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
LH89_09425	COG2259	Doxx family
LH89_09430	COG0435	Glutathione S-transferase
LH89_09435	COG0583	DNA-binding transcription factor activity
LH89_09440	COG1741	Belongs to the pirin family
LH89_09445	COG0735	belongs to the Fur family
LH89_09450	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
LH89_09455	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
LH89_09460	COG2937	Belongs to the GPAT DAPAT family
LH89_09465	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
LH89_09470	COG3161	chorismate lyase activity
LH89_09475	COG0459	protein refolding
LH89_09480	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
LH89_09500	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
LH89_09505	COG1324	tolerance protein
LH89_09510	COG4232	protein-disulfide reductase activity
LH89_09515	COG1309	transcriptional regulator
LH89_09535	COG1045	serine acetyltransferase
LH89_09550	COG0297	glycogen (starch) synthase activity
LH89_09550	COG0438	transferase activity, transferring glycosyl groups
LH89_09555	COG0297	glycogen (starch) synthase activity
LH89_09590	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
LH89_09600	COG1609	Transcriptional regulator
LH89_09605	COG0789	Transcriptional regulator
LH89_09620	COG2971	BadF BadG BcrA BcrD
LH89_09635	COG0456	acetyltransferase
LH89_09645	COG1175	transmembrane transport
LH89_09650	COG0395	ABC-type sugar transport system, permease component
LH89_09705	COG2351	hydroxyisourate hydrolase activity
LH89_09710	COG0110	maltose O-acetyltransferase activity
LH89_09720	COG3634	alkyl hydroperoxide reductase activity
LH89_09725	COG0450	alkyl hydroperoxide reductase
LH89_09730	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LH89_09740	COG1120	ATPase activity
LH89_09770	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
LH89_09775	COG0840	transmembrane signaling receptor activity
LH89_09780	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
LH89_09795	COG0084	hydrolase, TatD family'
LH89_09810	COG2823	Periplasmic or secreted lipoprotein
LH89_09815	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
LH89_09830	COG4106	trans-aconitate 2-methyltransferase activity
LH89_09835	COG3726	membrane protein affecting hemolysin expression
LH89_09840	COG0560	Phosphoserine phosphatase
LH89_09855	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
LH89_09860	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
LH89_09870	COG0006	proline dipeptidase activity
LH89_09875	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
LH89_09880	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
LH89_09895	COG3477	response to acidic pH
LH89_09900	COG0747	negative chemotaxis
LH89_09920	COG3157	Type VI secretion system effector, Hcp
LH89_09925	COG4977	sequence-specific DNA binding
LH89_09925	COG1917	Cupin 2, conserved barrel domain protein
LH89_09930	COG1917	Cupin 2, conserved barrel domain protein
LH89_09930	COG2169	Transcriptional regulator
LH89_09935	COG1070	Carbohydrate kinase
LH89_09940	COG4806	L-rhamnose isomerase
LH89_09945	COG0235	Class ii aldolase
LH89_09960	COG0840	transmembrane signaling receptor activity
LH89_09965	COG1414	Transcriptional regulator
LH89_09970	COG0288	reversible hydration of carbon dioxide
LH89_09975	COG0659	secondary active sulfate transmembrane transporter activity
LH89_09980	COG1418	mRNA catabolic process
LH89_09990	COG1605	Chorismate mutase
LH89_10005	COG0583	DNA-binding transcription factor activity
LH89_10015	COG4608	Belongs to the ABC transporter superfamily
LH89_10020	COG0444	Belongs to the ABC transporter superfamily
LH89_10025	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LH89_10035	COG0747	negative chemotaxis
LH89_10045	COG2814	Major facilitator Superfamily
LH89_10060	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LH89_10070	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
LH89_10075	COG1172	Belongs to the binding-protein-dependent transport system permease family
LH89_10080	COG1172	Belongs to the binding-protein-dependent transport system permease family
LH89_10085	COG1129	ABC transporter
LH89_10095	COG1349	DNA-binding transcription factor activity
LH89_10125	COG3811	Belongs to the UPF0386 family
LH89_10130	COG2226	methyltransferase
LH89_10140	COG0795	lipopolysaccharide-transporting ATPase activity
LH89_10145	COG0795	lipopolysaccharide-transporting ATPase activity
LH89_10150	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
LH89_10155	COG2927	DNA polymerase III (CHI subunit)
LH89_10160	COG0525	valine-tRNA ligase activity
LH89_10165	COG0840	transmembrane signaling receptor activity
LH89_10170	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
LH89_10175	COG0454	-acetyltransferase
LH89_10190	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
LH89_10195	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
LH89_10200	COG2723	6-phospho-beta-galactosidase activity
LH89_10205	COG1263	PTS System
LH89_10205	COG2190	(PTS) system
LH89_10205	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LH89_10210	COG2731	YhcH YjgK YiaL family protein
LH89_10215	COG0540	Belongs to the ATCase OTCase family
LH89_10220	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
LH89_10235	COG2308	Evidence 4 Homologs of previously reported genes of
LH89_10265	COG0601	transmembrane transport
LH89_10270	COG4166	transmembrane transport
LH89_10280	COG1328	CTP reductase activity
LH89_10300	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
LH89_10305	COG1518	maintenance of DNA repeat elements
LH89_10320	COG1857	crispr-associated protein
LH89_10380	COG0848	biopolymer transport protein
LH89_10385	COG0811	peptide transport
LH89_10390	COG0626	cystathionine gamma-synthase activity
LH89_10395	COG0586	Pfam SNARE associated Golgi protein
LH89_10400	COG2207	Transcriptional regulator
LH89_10405	COG0778	Nitroreductase
LH89_10410	COG1979	alcohol dehydrogenase
LH89_10415	COG0656	L-ascorbic acid biosynthetic process
LH89_10420	COG2132	Multicopper oxidase
LH89_10425	COG0204	Acyl-transferase
LH89_10435	COG2249	NAD(P)H dehydrogenase (quinone) activity
LH89_10440	COG0583	DNA-binding transcription factor activity
LH89_10460	COG0187	DNA topoisomerase II activity
LH89_10465	COG3150	esterase
LH89_10470	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
LH89_10475	COG3151	Protein conserved in bacteria
LH89_10480	COG0494	nUDIX hydrolase
LH89_10485	COG1538	Outer membrane efflux protein
LH89_10490	COG5463	Belongs to the UPF0441 family
LH89_10495	COG0754	glutathionylspermidine amidase activity
LH89_10500	COG3384	dioxygenase
LH89_10505	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
LH89_10510	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
LH89_10515	COG3107	peptidoglycan biosynthetic process
LH89_10520	COG0792	nuclease activity
LH89_10525	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
LH89_10530	COG2823	Periplasmic or secreted lipoprotein
LH89_10540	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
LH89_10545	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
LH89_10550	COG5002	protein histidine kinase activity
LH89_10550	COG0784	Response regulator, receiver
LH89_10550	COG2198	Histidine kinase
LH89_10555	COG1242	4 iron, 4 sulfur cluster binding
LH89_10560	COG0069	glutamate synthase activity
LH89_10560	COG0070	glutamate synthase
LH89_10560	COG0067	glutamate synthase
LH89_10565	COG0493	'glutamate synthase
LH89_10575	COG2969	positive regulation of protein catabolic process
LH89_10580	COG0625	glutathione transferase activity
LH89_10585	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
LH89_10600	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
LH89_10605	COG3105	Protein conserved in bacteria
LH89_10610	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LH89_10615	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LH89_10620	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
LH89_10625	COG5007	Belongs to the BolA IbaG family
LH89_10630	COG3113	response to antibiotic
LH89_10635	COG2854	intermembrane phospholipid transfer
LH89_10640	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
LH89_10645	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
LH89_10650	COG1127	ABC transporter
LH89_10655	COG0530	calcium, potassium:sodium antiporter activity
LH89_10660	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
LH89_10660	COG0517	IMP dehydrogenase activity
LH89_10665	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
LH89_10670	COG3117	lipopolysaccharide transmembrane transporter activity
LH89_10675	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
LH89_10680	COG1137	ATPase activity
LH89_10685	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
LH89_10695	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
LH89_10700	COG1660	Displays ATPase and GTPase activities
LH89_10705	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
LH89_10710	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
LH89_10715	COG0312	modulator of DNA gyrase
LH89_10720	COG3028	Belongs to the UPF0307 family
LH89_10725	COG1280	lysine exporter protein (LysE YggA)
LH89_10735	COG1289	transmembrane transporter activity
LH89_10740	COG1566	PFAM secretion protein HlyD family protein
LH89_10750	COG0583	DNA-binding transcription factor activity
LH89_10755	COG0312	modulator of DNA gyrase
LH89_10760	COG3164	Protein of unknown function
LH89_10765	COG1530	ribonuclease E activity
LH89_10775	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
LH89_10780	COG1792	Involved in formation and maintenance of cell shape
LH89_10785	COG1077	Cell shape determining protein MreB Mrl
LH89_10790	COG2200	EAL domain
LH89_10790	COG2199	diguanylate cyclase activity
LH89_10795	COG0604	alcohol dehydrogenase
LH89_10800	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
LH89_10805	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
LH89_10810	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
LH89_10815	COG0511	ligase activity, forming carbon-carbon bonds
LH89_10820	COG0439	Biotin carboxylase
LH89_10825	COG3924	membrane
LH89_10830	COG4145	pantothenate transmembrane transporter activity
LH89_10835	COG2264	protein methyltransferase activity
LH89_10850	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
LH89_10855	COG1064	alcohol dehydrogenase
LH89_10860	COG4221	oxidoreductase activity
LH89_10875	COG4221	oxidoreductase activity
LH89_10885	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LH89_10890	COG0765	amino acid transport
LH89_10895	COG0504	CTP synthase activity
LH89_10900	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LH89_10905	COG4597	amino acid ABC transporter
LH89_10910	COG0765	amino acid transport
LH89_10915	COG1126	abc transporter atp-binding protein
LH89_10950	COG0138	bifunctional purine biosynthesis protein purh
LH89_10955	COG0151	Belongs to the GarS family
LH89_10965	COG0776	regulation of translation
LH89_10970	COG3068	Protein conserved in bacteria
LH89_10975	COG1515	deoxyribonuclease V activity
LH89_10980	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
LH89_10985	COG2816	NAD+ diphosphatase activity
LH89_10990	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
LH89_10995	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
LH89_11000	COG0352	thiamine-phosphate diphosphorylase activity
LH89_11005	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
LH89_11010	COG2104	thiamine diphosphate biosynthetic process
LH89_11015	COG2022	thiamine diphosphate biosynthetic process
LH89_11020	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
LH89_11040	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
LH89_11045	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
LH89_11050	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LH89_11070	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
LH89_11100	COG0250	Participates in transcription elongation, termination and antitermination
LH89_11105	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
LH89_11110	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
LH89_11145	COG1072	(Pantothenic acid kinase))
LH89_11185	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
LH89_11190	COG1739	Uncharacterized protein family UPF0029
LH89_11195	COG0006	proline dipeptidase activity
LH89_11200	COG1250	3-hydroxyacyl-CoA dehydrogenase
LH89_11200	COG1024	Enoyl-CoA hydratase
LH89_11205	COG0183	Belongs to the thiolase family
LH89_11220	COG0640	Transcriptional regulator
LH89_11235	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
LH89_11250	COG0084	hydrolase, TatD family'
LH89_11255	COG0805	protein transport
LH89_11265	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
LH89_11270	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
LH89_11275	COG3165	ubiquinone biosynthetic process from chorismate
LH89_11280	COG2226	methyltransferase
LH89_11285	COG1322	Protein conserved in bacteria
LH89_11290	COG0165	Argininosuccinate lyase
LH89_11295	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
LH89_11300	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
LH89_11305	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
LH89_11310	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
LH89_11330	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
LH89_11340	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
LH89_11345	COG0583	DNA-binding transcription factor activity
LH89_11365	COG1045	serine acetyltransferase
LH89_11370	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
LH89_11375	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
LH89_11380	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
LH89_11385	COG4942	peptidase
LH89_11390	COG2861	carbohydrate metabolic process
LH89_11395	COG1063	alcohol dehydrogenase
LH89_11400	COG0156	8-amino-7-oxononanoate synthase activity
LH89_11405	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
LH89_11410	COG0859	PFAM glycosyl transferase family 9
LH89_11415	COG0859	PFAM glycosyl transferase family 9
LH89_11420	COG0859	PFAM glycosyl transferase family 9
LH89_11440	COG0438	transferase activity, transferring glycosyl groups
LH89_11450	COG1519	Transferase
LH89_11460	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
LH89_11465	COG1216	Glycosyl transferase, family 2
LH89_11470	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
LH89_11485	COG2003	Belongs to the UPF0758 family
LH89_11490	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
LH89_11495	COG0756	dUTP diphosphatase activity
LH89_11500	COG1309	transcriptional regulator
LH89_11505	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
LH89_11510	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
LH89_11515	COG2149	membrane
LH89_11530	COG4948	Mandelate Racemase Muconate Lactonizing
LH89_11535	COG4172	Belongs to the ABC transporter superfamily
LH89_11540	COG0747	negative chemotaxis
LH89_11545	COG0601	transmembrane transport
LH89_11550	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LH89_11590	COG4608	Belongs to the ABC transporter superfamily
LH89_11595	COG0444	Belongs to the ABC transporter superfamily
LH89_11605	COG0601	transmembrane transport
LH89_11610	COG0747	negative chemotaxis
LH89_11620	COG0583	DNA-binding transcription factor activity
LH89_11625	COG1561	YicC-like family, N-terminal region
LH89_11670	COG3916	Acyl-homoserine-lactone synthase
LH89_11675	COG2771	luxR family
LH89_11695	COG0318	PFAM AMP-dependent synthetase and ligase
LH89_11730	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
LH89_11755	COG2091	lysine biosynthetic process via aminoadipic acid
LH89_11770	COG0577	efflux transmembrane transporter activity
LH89_11775	COG0577	efflux transmembrane transporter activity
LH89_11775	COG1136	(ABC) transporter
LH89_11780	COG2207	Transcriptional regulator
LH89_11780	COG1917	Cupin 2, conserved barrel domain protein
LH89_11820	COG0546	phosphoglycolate phosphatase activity
LH89_11825	COG2313	pseudouridylate synthase activity
LH89_11830	COG0697	spore germination
LH89_11835	COG1846	Transcriptional regulator
LH89_11840	COG0137	argininosuccinate synthase activity
LH89_11860	COG1609	Transcriptional regulator
LH89_11860	COG2207	Transcriptional regulator
LH89_11865	COG4214	carbohydrate transport
LH89_11870	COG1129	ABC transporter
LH89_11875	COG4213	ABC transporter substrate-binding protein
LH89_11880	COG2115	Belongs to the xylose isomerase family
LH89_11885	COG1070	Carbohydrate kinase
LH89_11890	COG1012	belongs to the aldehyde dehydrogenase family
LH89_11895	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
LH89_11900	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
LH89_11905	COG0840	transmembrane signaling receptor activity
LH89_11910	COG3722	fumarate hydratase activity
LH89_11915	COG0246	Mannitol dehydrogenase
LH89_11920	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
LH89_11920	COG2213	PTS system mannitol-specific
LH89_11940	COG3842	ATPase activity
LH89_11970	COG4104	PAAR repeat-containing protein
LH89_11970	COG3209	COG3209 Rhs family protein
LH89_11980	COG3501	Rhs element vgr protein
LH89_11990	COG0477	Major facilitator Superfamily
LH89_11995	COG0751	glycine-tRNA ligase activity
LH89_12000	COG0752	glycyl-tRNA synthetase alpha subunit
LH89_12005	COG0730	response to heat
LH89_12010	COG2818	Glycosylase
LH89_12015	COG0456	acetyltransferase
LH89_12020	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
LH89_12035	COG3977	Valine--pyruvate aminotransferase
LH89_12045	COG0747	negative chemotaxis
LH89_12055	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LH89_12060	COG4172	Belongs to the ABC transporter superfamily
LH89_12065	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LH89_12080	COG0837	glucose binding
LH89_12100	COG0583	DNA-binding transcription factor activity
LH89_12125	COG4191	Histidine kinase
LH89_12130	COG1804	L-carnitine dehydratase bile acid-inducible protein F
LH89_12150	COG1509	lysine 2,3-aminomutase activity
LH89_12160	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
LH89_12165	COG1522	sequence-specific DNA binding
LH89_12180	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
LH89_12185	COG0471	metal ion transport
LH89_12190	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
LH89_12200	COG1234	tRNA 3'-trailer cleavage
LH89_12205	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
LH89_12215	COG0339	signal peptide processing
LH89_12220	COG0742	ribosomal rna small subunit methyltransferase
LH89_12235	COG0187	DNA topoisomerase II activity
LH89_12240	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
LH89_12245	COG0592	DNA-directed DNA polymerase activity
LH89_12255	COG0594	ribonuclease P activity
LH89_12260	COG0706	membrane insertase activity
LH89_12265	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
LH89_12275	COG1396	sequence-specific DNA binding
LH89_12285	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
LH89_12295	COG1733	regulation of RNA biosynthetic process
LH89_12300	COG2910	NAD(P)H-binding
LH89_12315	COG2076	Multidrug Resistance protein
LH89_12320	COG2076	Multidrug Resistance protein
LH89_12325	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
LH89_12330	COG0726	polysaccharide deacetylase
LH89_12340	COG0463	Glycosyl transferase, family 2
LH89_12350	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
LH89_12350	COG0493	'glutamate synthase
LH89_12355	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
LH89_12360	COG2091	lysine biosynthetic process via aminoadipic acid
LH89_12365	COG2252	PERMEase
LH89_12370	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
LH89_12375	COG0765	amino acid transport
LH89_12380	COG0765	amino acid transport
LH89_12385	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LH89_12395	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
LH89_12400	COG0581	inorganic phosphate transmembrane transporter activity
LH89_12405	COG0573	inorganic phosphate transmembrane transporter activity
LH89_12410	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
LH89_12415	COG3706	GGDEF domain
LH89_12430	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
LH89_12465	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
LH89_12475	COG1028	Short-chain dehydrogenase reductase Sdr
LH89_12510	COG0463	Glycosyl transferase, family 2
LH89_12530	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
LH89_12560	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
LH89_12565	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
LH89_12575	COG0355	proton-transporting ATP synthase activity, rotational mechanism
LH89_12580	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
LH89_12585	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
LH89_12590	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
LH89_12595	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
LH89_12600	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
LH89_12610	COG0356	it plays a direct role in the translocation of protons across the membrane
LH89_12615	COG3312	ion transport
LH89_12620	COG0357	Ribosomal RNA small subunit methyltransferase G
LH89_12625	COG0445	tRNA wobble uridine modification
LH89_12630	COG0716	FMN binding
LH89_12635	COG1522	sequence-specific DNA binding
LH89_12640	COG2425	protein containing a von Willebrand factor type A (vWA) domain
LH89_12645	COG0714	Associated with various cellular activities
LH89_12650	COG3158	transport of potassium into the cell
LH89_12660	COG0745	RESPONSE REGULATOR receiver
LH89_12665	COG3111	PFAM Bacterial OB fold (BOF) protein
LH89_12670	COG1869	D-ribose catabolic process
LH89_12675	COG1129	ABC transporter
LH89_12680	COG1172	Belongs to the binding-protein-dependent transport system permease family
LH89_12685	COG1879	ABC-type sugar transport system periplasmic component
LH89_12690	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LH89_12695	COG1609	Transcriptional regulator
LH89_12720	COG1763	Mo-molybdopterin cofactor biosynthetic process
LH89_12730	COG3084	Protein conserved in bacteria
LH89_12735	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
LH89_12740	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
LH89_12745	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
LH89_12745	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
LH89_12755	COG3078	GTPase activator activity
LH89_12765	COG0635	Involved in the biosynthesis of porphyrin-containing compound
LH89_12780	COG3852	Histidine kinase
LH89_12785	COG0174	glutamine synthetase
LH89_12795	COG1011	Hydrolase
LH89_12800	COG1490	D-aminoacyl-tRNA deacylase activity
LH89_12805	COG0456	acetyltransferase
LH89_12810	COG2982	Protein involved in outer membrane biogenesis
LH89_12815	COG2233	PERMEase
LH89_12820	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
LH89_12825	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
LH89_12830	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
LH89_12840	COG0194	GDP metabolic process
LH89_12845	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
LH89_12850	COG2194	sulfuric ester hydrolase activity
LH89_12865	COG4221	oxidoreductase activity
LH89_12885	COG2814	Major facilitator Superfamily
LH89_12895	COG1175	transmembrane transport
LH89_12905	COG1653	transport
LH89_12930	COG3048	D-serine ammonia-lyase activity
LH89_12960	COG0395	ABC-type sugar transport system, permease component
LH89_12965	COG3842	ATPase activity
LH89_12980	COG2081	HI0933 family
LH89_12985	COG0306	phosphate transporter
LH89_12995	COG0589	response to stress
LH89_13010	COG0561	phosphatase activity
LH89_13050	COG0823	Involved in the tonB-independent uptake of proteins
LH89_13060	COG1069	ribulokinase activity
LH89_13070	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
LH89_13080	COG0477	Major facilitator Superfamily
LH89_13090	COG5645	(Lipo)protein
LH89_13095	COG0071	Belongs to the small heat shock protein (HSP20) family
LH89_13100	COG0071	Belongs to the small heat shock protein (HSP20) family
LH89_13105	COG0471	metal ion transport
LH89_13110	COG3290	protein histidine kinase activity
LH89_13115	COG4565	transcriptional regulatory protein
LH89_13120	COG3493	citrate carrier protein
LH89_13125	COG0747	negative chemotaxis
LH89_13130	COG0601	transmembrane transport
LH89_13135	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LH89_13140	COG0444	Belongs to the ABC transporter superfamily
LH89_13145	COG4608	Belongs to the ABC transporter superfamily
LH89_13160	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LH89_13170	COG2378	regulation of single-species biofilm formation
LH89_13185	COG0489	protein tyrosine kinase activity
LH89_13200	COG0457	Tetratricopeptide repeat
LH89_13210	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
LH89_13215	COG1301	dicarboxylic acid transport
LH89_13225	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LH89_13230	COG1942	4-Oxalocrotonate Tautomerase
LH89_13235	COG1295	ribonuclease BN
LH89_13240	COG0477	Major facilitator Superfamily
LH89_13250	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
LH89_13255	COG0425	Belongs to the sulfur carrier protein TusA family
LH89_13260	COG3714	YhhN family
LH89_13270	COG3776	membrane
LH89_13275	COG0742	ribosomal rna small subunit methyltransferase
LH89_13280	COG0552	protein localization to endoplasmic reticulum
LH89_13280	COG0552	protein localization to endoplasmic reticulum
LH89_13285	COG2884	Cell division ATP-binding protein ftsE
LH89_13290	COG2177	Part of the ABC transporter FtsEX involved in
LH89_13305	COG0683	leucine binding
LH89_13310	COG0559	Belongs to the binding-protein-dependent transport system permease family
LH89_13315	COG4177	L-phenylalanine transmembrane transporter activity
LH89_13320	COG0411	ABC transporter
LH89_13325	COG0410	ABC transporter
LH89_13330	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LH89_13340	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
LH89_13345	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
LH89_13360	COG0840	transmembrane signaling receptor activity
LH89_13370	COG0840	transmembrane signaling receptor activity
LH89_13375	COG0840	transmembrane signaling receptor activity
LH89_13385	COG0840	transmembrane signaling receptor activity
LH89_13395	COG1653	transport
LH89_13400	COG1175	transmembrane transport
LH89_13405	COG0395	ABC-type sugar transport system, permease component
LH89_13410	COG3842	ATPase activity
LH89_13415	COG0584	glycerophosphoryl diester phosphodiesterase
LH89_13420	COG0679	Auxin Efflux Carrier
LH89_13430	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
LH89_13450	COG2205	protein histidine kinase activity
LH89_13455	COG0745	RESPONSE REGULATOR receiver
LH89_13460	COG3678	ATP-independent chaperone mediated protein folding
LH89_13475	COG2801	Transposase and inactivated derivatives
LH89_13530	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
LH89_13535	COG0205	6-phosphofructokinase activity
LH89_13545	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
LH89_13550	COG2957	Belongs to the agmatine deiminase family
LH89_13555	COG1785	Belongs to the alkaline phosphatase family
LH89_13560	COG0149	triose-phosphate isomerase activity
LH89_13570	COG3152	Membrane
LH89_13580	COG1494	fructose-1,6-bisphosphatase
LH89_13590	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
LH89_13595	COG3074	FtsZ-dependent cytokinesis
LH89_13600	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
LH89_13605	COG1575	Belongs to the MenA family. Type 1 subfamily
LH89_13610	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
LH89_13615	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
LH89_13620	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
LH89_13625	COG1609	Transcriptional regulator
LH89_13630	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
LH89_13640	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
LH89_13645	COG0626	cystathionine gamma-synthase activity
LH89_13650	COG0527	aspartate kinase activity
LH89_13650	COG0460	homoserine dehydrogenase
LH89_13660	COG0678	peroxiredoxin activity
LH89_13660	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
LH89_13670	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
LH89_13685	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
LH89_13695	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
LH89_13735	COG0583	DNA-binding transcription factor activity
LH89_13740	COG3085	chromosome segregation
LH89_13750	COG2814	Major facilitator Superfamily
LH89_13760	COG3978	acetolactate synthase activity
LH89_13765	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
LH89_13775	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
LH89_13790	COG0583	DNA-binding transcription factor activity
LH89_13795	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
LH89_13805	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
LH89_13810	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
LH89_13810	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
LH89_13810	COG0506	proline dehydrogenase activity
LH89_13815	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
LH89_13830	COG0248	Ppx GppA phosphatase
LH89_13835	COG0513	Belongs to the DEAD box helicase family
LH89_13840	COG3118	belongs to the thioredoxin family
LH89_13845	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
LH89_13850	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
LH89_13855	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
LH89_13860	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
LH89_13865	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
LH89_13875	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
LH89_13880	COG2244	polysaccharide biosynthetic process
LH89_13885	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
LH89_13895	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
LH89_13900	COG1113	amino acid transport
LH89_13930	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
LH89_13940	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LH89_13945	COG0765	amino acid transport
LH89_13950	COG1126	abc transporter atp-binding protein
LH89_13960	COG1126	abc transporter atp-binding protein
LH89_13970	COG4597	amino acid ABC transporter
LH89_13975	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LH89_13995	COG1802	Transcriptional regulator
LH89_14000	COG3071	HemY protein
LH89_14005	COG2959	enzyme of heme biosynthesis
LH89_14010	COG1587	Uroporphyrinogen-III synthase
LH89_14015	COG0181	hydroxymethylbilane synthase activity
LH89_14035	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
LH89_14050	COG1011	Hydrolase
LH89_14055	COG0210	DNA helicase
LH89_14060	COG0598	Magnesium transport protein CorA
LH89_14065	COG3180	Ammonia monooxygenase
LH89_14075	COG2050	protein possibly involved in aromatic compounds catabolism
LH89_14080	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
LH89_14085	COG0514	ATP-dependent DNA helicase (RecQ)
LH89_14090	COG1280	lysine exporter protein (LysE YggA)
LH89_14105	COG1280	lysine exporter protein (LysE YggA)
LH89_14110	COG2267	carboxylic ester hydrolase activity
LH89_14115	COG0561	phosphatase activity
LH89_14120	COG0584	glycerophosphoryl diester phosphodiesterase
LH89_14125	COG2271	Major facilitator Superfamily
LH89_14130	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
LH89_14135	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
LH89_14140	COG0247	lactate metabolic process
LH89_14145	COG1741	Belongs to the pirin family
LH89_14155	COG1609	Transcriptional regulator
LH89_14160	COG3265	gluconokinase activity
LH89_14165	COG2610	gluconate transmembrane transporter activity
LH89_14170	COG2095	MarC family integral membrane protein
LH89_14175	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
LH89_14185	COG1278	Cold shock
LH89_14190	COG3275	phosphorelay sensor kinase activity
LH89_14205	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
LH89_14210	COG0297	glycogen (starch) synthase activity
LH89_14215	COG0058	SHG alpha-glucan phosphorylase activity
LH89_14220	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
LH89_14225	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
LH89_14230	COG2271	Major facilitator Superfamily
LH89_14235	COG2731	YhcH YjgK YiaL family protein
LH89_14245	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
LH89_14250	COG0705	Rhomboid family
LH89_14255	COG1349	DNA-binding transcription factor activity
LH89_14260	COG0058	SHG alpha-glucan phosphorylase activity
LH89_14265	COG1640	4-alpha-glucanotransferase
LH89_14270	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
LH89_14270	COG0316	Belongs to the HesB IscA family
LH89_14280	COG2267	carboxylic ester hydrolase activity
LH89_14290	COG2183	response to ionizing radiation
LH89_14300	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
LH89_14305	COG0745	RESPONSE REGULATOR receiver
LH89_14315	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
LH89_14320	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
LH89_14325	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
LH89_14330	COG1011	Hydrolase
LH89_14340	COG0494	nUDIX hydrolase
LH89_14345	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
LH89_14370	COG4796	Type ii and iii secretion system protein
LH89_14375	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
LH89_14380	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
LH89_14395	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
LH89_14400	COG0546	phosphoglycolate phosphatase activity
LH89_14410	COG4948	Mandelate Racemase Muconate Lactonizing
LH89_14415	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
LH89_14435	COG0076	glutamate decarboxylase activity
LH89_14455	COG3179	chitinase
LH89_14460	COG1404	Belongs to the peptidase S8 family
LH89_14475	COG2207	Transcriptional regulator
LH89_14475	COG4753	response regulator
LH89_14495	COG1765	OsmC-like protein
LH89_14500	COG3954	Phosphoribulokinase
LH89_14510	COG0429	hydrolase of the alpha beta-hydrolase fold
LH89_14520	COG0488	(ABC) transporter
LH89_14525	COG2249	NAD(P)H dehydrogenase (quinone) activity
LH89_14530	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
LH89_14530	COG0475	glutathione-regulated potassium exporter activity
LH89_14535	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
LH89_14545	COG1047	Peptidyl-prolyl cis-trans
LH89_14550	COG2140	Oxalate decarboxylase
LH89_14565	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
LH89_14575	COG2900	Belongs to the SlyX family
LH89_14580	COG0545	Peptidyl-prolyl cis-trans isomerase
LH89_14585	COG0642	Histidine kinase
LH89_14590	COG0745	RESPONSE REGULATOR receiver
LH89_14595	COG2194	sulfuric ester hydrolase activity
LH89_14600	COG2964	Protein conserved in bacteria
LH89_14605	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
LH89_14610	COG2923	Belongs to the DsrF TusC family
LH89_14615	COG2168	tRNA wobble position uridine thiolation
LH89_14620	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
LH89_14625	COG0049	tRNA binding
LH89_14630	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
LH89_14635	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
LH89_14650	COG0051	transcription antitermination factor activity, RNA binding
LH89_14655	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
LH89_14660	COG0088	Forms part of the polypeptide exit tunnel
LH89_14665	COG0089	rRNA binding
LH89_14670	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
LH89_14680	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
LH89_14690	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
LH89_14715	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
LH89_14720	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
LH89_14730	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
LH89_14740	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
LH89_14745	COG1841	ribosomal large subunit assembly
LH89_14750	COG0200	Binds to the 23S rRNA
LH89_14755	COG0201	protein transport
LH89_14765	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
LH89_14775	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
LH89_14785	COG0203	ribosomal protein L17
LH89_14795	COG1970	mechanosensitive ion channel activity
LH89_14800	COG0569	domain protein
LH89_14805	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
LH89_14805	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
LH89_14810	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
LH89_14815	COG0242	peptide deformylase activity
LH89_14820	COG0758	DNA mediated transformation
LH89_14825	COG2922	Belongs to the Smg family
LH89_14840	COG0009	L-threonylcarbamoyladenylate synthase
LH89_14845	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
LH89_14855	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
LH89_14880	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
LH89_14885	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
LH89_14895	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
LH89_14910	COG0646	methionine synthase
LH89_14910	COG1410	methionine synthase
LH89_14925	COG0471	metal ion transport
LH89_14930	COG1283	sodium-dependent phosphate transmembrane transporter activity
LH89_14935	COG0840	transmembrane signaling receptor activity
LH89_14940	COG0527	aspartate kinase activity
LH89_14945	COG0166	Belongs to the GPI family
LH89_14950	COG4124	Belongs to the glycosyl hydrolase 26 family
LH89_14960	COG1509	lysine 2,3-aminomutase activity
LH89_14965	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
LH89_14975	COG3040	lipid binding
LH89_14980	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
LH89_14985	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
LH89_14990	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
LH89_14995	COG1053	succinate dehydrogenase
LH89_15000	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
LH89_15005	COG1511	domain protein
LH89_15005	COG3264	Mechanosensitive ion channel
LH89_15010	COG0688	phosphatidylethanolamine metabolic process
LH89_15015	COG1162	GTPase activity
LH89_15020	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
LH89_15080	COG1309	transcriptional regulator
LH89_15085	COG4178	(ABC) transporter
LH89_15090	COG4774	siderophore transport
LH89_15100	COG1595	DNA-templated transcription, initiation
LH89_15105	COG3712	iron ion homeostasis
LH89_15125	COG0312	modulator of DNA gyrase
LH89_15130	COG0312	modulator of DNA gyrase
LH89_15200	COG0840	transmembrane signaling receptor activity
LH89_15255	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
LH89_15260	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
LH89_15280	COG2205	protein histidine kinase activity
LH89_15285	COG3604	Transcriptional regulator
LH89_15300	COG0840	transmembrane signaling receptor activity
LH89_15305	COG0583	DNA-binding transcription factor activity
LH89_15315	COG1473	amidohydrolase
LH89_15320	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
LH89_15325	COG1846	Transcriptional regulator
LH89_15330	COG1764	response to oxidative stress
LH89_15340	COG1126	abc transporter atp-binding protein
LH89_15345	COG0765	amino acid transport
LH89_15365	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LH89_15375	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LH89_15395	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
LH89_15395	COG0438	transferase activity, transferring glycosyl groups
LH89_15405	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
LH89_15420	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
LH89_15440	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
LH89_15450	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
LH89_15450	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
LH89_15455	COG0802	atpase or kinase
LH89_15465	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
LH89_15470	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
LH89_15475	COG1923	regulation of RNA biosynthetic process
LH89_15480	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
LH89_15485	COG0330	HflC and HflK could
LH89_15490	COG0330	HflC and HflK could
LH89_15495	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
LH89_15500	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
LH89_15505	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
LH89_15510	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
LH89_15515	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
LH89_15520	COG1678	Uncharacterized ACR, COG1678
LH89_15525	COG0189	ligase activity
LH89_15530	COG1385	rRNA (uridine-N3-)-methyltransferase activity
LH89_15535	COG2356	endonuclease I
LH89_15540	COG3091	SprT-like family
LH89_15545	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
LH89_15560	COG1166	arginine decarboxylase activity
LH89_15565	COG0738	Major facilitator superfamily
LH89_15570	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
LH89_15575	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
LH89_15580	COG0126	phosphoglycerate kinase activity
LH89_15590	COG0668	transmembrane transport
LH89_15595	COG1414	Transcriptional regulator
LH89_15600	COG2968	Membrane
LH89_15605	COG0583	DNA-binding transcription factor activity
LH89_15610	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
LH89_15615	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
LH89_15620	COG0604	alcohol dehydrogenase
LH89_15625	COG0583	DNA-binding transcription factor activity
LH89_15630	COG0840	transmembrane signaling receptor activity
LH89_15635	COG0488	(ABC) transporter
LH89_15645	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
LH89_15650	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
LH89_15655	COG0406	alpha-ribazole phosphatase activity
LH89_15660	COG2207	Transcriptional regulator
LH89_15660	COG3708	Transcriptional regulator
LH89_15665	COG3045	CreA protein
LH89_15670	COG0745	RESPONSE REGULATOR receiver
LH89_15675	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
LH89_15685	COG0083	homoserine kinase activity
LH89_15695	COG3022	response to hydroperoxide
LH89_15700	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
LH89_15705	COG3706	GGDEF domain
LH89_15710	COG0521	Mo-molybdopterin cofactor biosynthetic process
LH89_15720	COG1584	GPR1 FUN34 yaaH family protein
LH89_15730	COG0484	heat shock protein binding
LH89_15735	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
LH89_15740	COG0583	DNA-binding transcription factor activity
LH89_15745	COG0268	Binds directly to 16S ribosomal RNA
LH89_15750	COG0196	riboflavin kinase activity
LH89_15755	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
LH89_15760	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
LH89_15765	COG1047	Peptidyl-prolyl cis-trans
LH89_15770	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
LH89_15785	COG0505	Belongs to the CarA family
LH89_15790	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
LH89_15795	COG1280	lysine exporter protein (LysE YggA)
LH89_15800	COG2966	Psort location CytoplasmicMembrane, score
LH89_15805	COG3610	response to peptide
LH89_15810	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
LH89_15820	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
LH89_15825	COG2967	ApaG domain
LH89_15830	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
LH89_15835	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
LH89_15840	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
LH89_15845	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
LH89_15850	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
LH89_15855	COG0564	pseudouridine synthase activity
LH89_15860	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
LH89_15865	COG0417	DNA replication proofreading
LH89_15885	COG0411	ABC transporter
LH89_15895	COG3157	Type VI secretion system effector, Hcp
LH89_15920	COG0586	Pfam SNARE associated Golgi protein
LH89_15925	COG0440	acetolactate synthase activity
LH89_15930	COG0028	Belongs to the TPP enzyme family
LH89_15940	COG3840	Part of the ABC transporter complex ThiBPQ involved in thiamine import. Responsible for energy coupling to the transport system
LH89_15945	COG1178	ABC-type Fe3 transport system permease component
LH89_15950	COG4143	(ABC) transporter
LH89_15955	COG4533	DNA binding
LH89_15965	COG3033	Beta-eliminating lyase
LH89_15975	COG0066	3-isopropylmalate dehydratase activity
LH89_15980	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
LH89_15985	COG0473	3-isopropylmalate dehydrogenase activity
LH89_15990	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
LH89_15995	COG1022	Amp-dependent synthetase and ligase
LH89_16000	COG0028	Belongs to the TPP enzyme family
LH89_16010	COG1609	Transcriptional regulator
LH89_16025	COG2001	Belongs to the MraZ family
LH89_16030	COG0275	rRNA processing
LH89_16035	COG3116	cell division
LH89_16040	COG0768	penicillin binding
LH89_16045	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
LH89_16050	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
LH89_16055	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
LH89_16060	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
LH89_16065	COG0772	Belongs to the SEDS family
LH89_16070	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
LH89_16075	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
LH89_16080	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
LH89_16085	COG0849	cell division
LH89_16090	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
LH89_16095	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
LH89_16110	COG0653	protein targeting
LH89_16115	COG0494	nUDIX hydrolase
LH89_16120	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
LH89_16125	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
LH89_16130	COG0237	dephospho-CoA kinase activity
LH89_16140	COG1459	type II secretion system
LH89_16145	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
LH89_16150	COG4969	Belongs to the N-Me-Phe pilin family
LH89_16160	COG3248	Nucleoside-binding outer membrane protein
LH89_16165	COG3023	N-Acetylmuramoyl-L-alanine amidase
LH89_16170	COG3725	Membrane protein required for beta-lactamase induction
LH89_16175	COG1113	amino acid transport
LH89_16180	COG2186	Transcriptional regulator
LH89_16185	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
LH89_16190	COG0508	dehydrogenase complex catalyzes the overall conversion of
LH89_16195	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
LH89_16205	COG2079	MmgE PrpD family protein
LH89_16215	COG4771	TonB-dependent receptor
LH89_16230	COG3112	Uncharacterised protein family (UPF0231)
LH89_16235	COG0861	Integral membrane protein TerC family
LH89_16240	COG1028	Short-chain dehydrogenase reductase Sdr
LH89_16245	COG2731	YhcH YjgK YiaL family protein
LH89_16260	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
LH89_16265	COG1454	alcohol dehydrogenase
LH89_16270	COG3395	kinase activity
LH89_16275	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
LH89_16280	COG1349	DNA-binding transcription factor activity
LH89_16320	COG2368	4-hydroxyphenylacetate
LH89_16325	COG0803	Belongs to the bacterial solute-binding protein 9 family
LH89_16330	COG1108	ABC-type Mn2 Zn2 transport systems permease components
LH89_16335	COG1121	(ABC) transporter
LH89_16345	COG0725	ABC transporter, periplasmic molybdate-binding protein
LH89_16355	COG2971	BadF BadG BcrA BcrD
LH89_16375	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
LH89_16385	COG1175	transmembrane transport
LH89_16390	COG0395	ABC-type sugar transport system, permease component
LH89_16395	COG1609	Transcriptional regulator
LH89_16495	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
LH89_16505	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
LH89_16510	COG0432	Pfam Uncharacterised protein family UPF0047
LH89_16515	COG2199	diguanylate cyclase activity
LH89_16515	COG2203	Gaf domain
LH89_16520	COG0745	RESPONSE REGULATOR receiver
LH89_16520	COG3706	GGDEF domain
LH89_16525	COG0840	transmembrane signaling receptor activity
LH89_16530	COG1518	maintenance of DNA repeat elements
LH89_16535	COG1203	CRISPR-associated helicase, Cas3
LH89_16560	COG1448	Aminotransferase
LH89_16570	COG1522	sequence-specific DNA binding
LH89_16595	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
LH89_16600	COG0305	Participates in initiation and elongation during chromosome replication
LH89_16610	COG2124	cytochrome p450
LH89_16625	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
LH89_16650	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
LH89_16655	COG4149	molybdate abc transporter
LH89_16665	COG3842	ATPase activity
LH89_16670	COG0583	DNA-binding transcription factor activity
LH89_16675	COG0019	diaminopimelate decarboxylase activity
LH89_16680	COG1609	Transcriptional regulator
LH89_16685	COG1447	Phosphotransferase system cellobiose-specific component IIA
LH89_16690	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
LH89_16695	COG2723	6-phospho-beta-galactosidase activity
LH89_16700	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
LH89_16705	COG2186	Transcriptional regulator
LH89_16715	COG1609	Transcriptional regulator
LH89_16725	COG3711	transcriptional antiterminator
LH89_16735	COG2723	6-phospho-beta-galactosidase activity
LH89_16740	COG2723	6-phospho-beta-galactosidase activity
LH89_16745	COG0318	PFAM AMP-dependent synthetase and ligase
LH89_16745	COG0204	Acyl-transferase
LH89_16750	COG0477	Major facilitator Superfamily
LH89_16755	COG2153	protein acetylation
LH89_16765	COG0635	Involved in the biosynthesis of porphyrin-containing compound
LH89_16770	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
LH89_16775	COG1872	DUF167
LH89_16780	COG0762	integral membrane protein
LH89_16785	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
LH89_16790	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
LH89_16795	COG2805	Type II/IV secretion system protein
LH89_16805	COG0402	S-adenosylhomocysteine deaminase activity
LH89_16820	COG1959	2 iron, 2 sulfur cluster binding
LH89_16825	COG0557	exoribonuclease II activity
LH89_16830	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
LH89_16845	COG0840	transmembrane signaling receptor activity
LH89_16850	COG1073	alpha beta
LH89_16860	COG2965	DNA replication, synthesis of RNA primer
LH89_16870	COG0359	binds to the 23S rRNA
LH89_16880	COG3061	Opacity-associated protein A
LH89_16885	COG0545	Peptidyl-prolyl cis-trans isomerase
LH89_16895	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
LH89_16900	COG0737	Belongs to the 5'-nucleotidase family
LH89_16905	COG1218	3'(2'),5'-bisphosphate nucleotidase
LH89_16915	COG1253	flavin adenine dinucleotide binding
LH89_16920	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
LH89_16925	COG0729	surface antigen
LH89_16930	COG2911	Protein conserved in bacteria
LH89_16935	COG2105	PFAM AIG2 family protein
LH89_16940	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
LH89_16950	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
LH89_16955	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
LH89_16960	COG1968	undecaprenyl-diphosphatase activity
LH89_16965	COG0617	tRNA 3'-terminal CCA addition
LH89_16970	COG4991	sh3 domain protein
LH89_16975	COG3025	triphosphatase activity
LH89_16980	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
LH89_16985	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
LH89_16985	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
LH89_16990	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
LH89_16995	COG3530	Putative quorum-sensing-regulated virulence factor
LH89_17015	COG0840	transmembrane signaling receptor activity
LH89_17020	COG2721	sulfolactate sulfo-lyase activity
LH89_17030	COG2271	Major facilitator Superfamily
LH89_17035	COG4948	Mandelate Racemase Muconate Lactonizing
LH89_17040	COG4948	Mandelate Racemase Muconate Lactonizing
LH89_17050	COG2084	Dehydrogenase
LH89_17055	COG1929	Belongs to the glycerate kinase type-1 family
LH89_17065	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
LH89_17070	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
LH89_17075	COG3956	TIGRFAM MazG family protein
LH89_17080	COG0504	CTP synthase activity
LH89_17095	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
LH89_17105	COG0602	queuosine metabolic process
LH89_17110	COG0720	synthase
LH89_17130	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
LH89_17135	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
LH89_17140	COG0175	sulfate reduction
LH89_17150	COG1648	precorrin-2 dehydrogenase activity
LH89_17150	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
LH89_17155	COG0175	sulfate reduction
LH89_17160	COG2895	sulfate adenylyltransferase (ATP) activity
LH89_17165	COG0529	Catalyzes the synthesis of activated sulfate
LH89_17175	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
LH89_17180	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
LH89_17185	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
LH89_17190	COG0585	pseudouridine synthase activity
LH89_17195	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
LH89_17200	COG1388	LysM domain
LH89_17200	COG4942	peptidase
LH89_17205	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
LH89_17210	COG0442	prolyl-tRNA aminoacylation
LH89_17215	COG1720	tRNA m6t6A37 methyltransferase activity
LH89_17225	COG1464	Belongs to the NlpA lipoprotein family
LH89_17230	COG2011	ABC-type metal ion transport system permease component
LH89_17240	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
LH89_17280	COG0477	Major facilitator Superfamily
LH89_17285	COG5544	Lipoprotein
LH89_17290	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
LH89_17295	COG0045	succinate-CoA ligase (ADP-forming) activity
LH89_17295	COG1042	CoA-binding domain protein
LH89_17295	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
LH89_17305	COG3118	belongs to the thioredoxin family
LH89_17310	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
LH89_17315	COG2814	Major facilitator Superfamily
LH89_17320	COG1566	PFAM secretion protein HlyD family protein
LH89_17325	COG1846	Transcriptional regulator
LH89_17335	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
LH89_17340	COG2814	Major facilitator Superfamily
LH89_17345	COG2113	Glycine betaine
LH89_17350	COG4176	ABC-type proline glycine betaine transport system permease component
LH89_17355	COG4175	Glycine betaine
LH89_17370	COG1953	Uracil, thiamine, allantoin
LH89_17420	COG0765	amino acid transport
LH89_17435	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
LH89_17450	COG0436	Aminotransferase
LH89_17455	COG0235	Class ii aldolase
LH89_17460	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
LH89_17465	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
LH89_17470	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
LH89_17475	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
LH89_17480	COG1960	acyl-CoA dehydrogenase activity
LH89_17485	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
LH89_17490	COG0121	glutamine amidotransferase
LH89_17495	COG3034	peptidoglycan biosynthetic process
LH89_17500	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
LH89_17505	COG2195	Cleaves the N-terminal amino acid of tripeptides
LH89_17515	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
LH89_17530	COG2199	diguanylate cyclase activity
LH89_17540	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
LH89_17545	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
LH89_17555	COG0582	viral genome integration into host DNA
LH89_17615	COG2161	toxin-antitoxin pair type II binding
LH89_17635	COG1028	Short-chain dehydrogenase reductase Sdr
LH89_17645	COG2026	Addiction module toxin, RelE StbE family
LH89_17655	COG1696	Membrane protein involved in D-alanine export
LH89_17660	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
LH89_17670	COG0583	DNA-binding transcription factor activity
LH89_17695	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
LH89_17705	COG3275	phosphorelay sensor kinase activity
LH89_17715	COG1966	Carbon starvation protein
LH89_17720	COG2879	small protein
LH89_17725	COG0523	cobalamin synthesis protein
LH89_17735	COG2207	Transcriptional regulator
LH89_17745	COG0688	phosphatidylethanolamine metabolic process
LH89_17750	COG1172	Belongs to the binding-protein-dependent transport system permease family
LH89_17755	COG1172	Belongs to the binding-protein-dependent transport system permease family
LH89_17760	COG1129	ABC transporter
LH89_17765	COG1879	ABC-type sugar transport system periplasmic component
LH89_17810	COG3038	cytochrome b561
LH89_17830	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
LH89_17835	COG2137	regulation of response to DNA damage stimulus
LH89_17840	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
LH89_17845	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
LH89_17870	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
LH89_17875	COG1238	metal cluster binding
LH89_17880	COG2918	glutathione biosynthetic process
LH89_17885	COG1854	S-ribosylhomocysteine lyase activity
LH89_17890	COG4137	Cytochrome C assembly protein
LH89_17895	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
LH89_17900	COG0228	four-way junction DNA binding
LH89_17905	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
LH89_17910	COG0336	Belongs to the RNA methyltransferase TrmD family
LH89_17915	COG0335	large ribosomal subunit rRNA binding
LH89_17935	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
LH89_17940	COG0287	Prephenate dehydrogenase
LH89_17940	COG1605	Chorismate mutase
LH89_17945	COG0077	Prephenate dehydratase
LH89_17945	COG1605	Chorismate mutase
LH89_17950	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
LH89_17955	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
LH89_17960	COG0564	pseudouridine synthase activity
LH89_17970	COG0542	response to heat
LH89_18000	COG3021	interspecies interaction between organisms
LH89_18005	COG0741	lytic transglycosylase activity
LH89_18005	COG1388	LysM domain
LH89_18010	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LH89_18015	COG2226	methyltransferase
LH89_18020	COG0328	RNA-DNA hybrid ribonuclease activity
LH89_18025	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
LH89_18035	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
LH89_18040	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
LH89_18045	COG1780	Probably involved in ribonucleotide reductase function
LH89_18055	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
LH89_18060	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
LH89_18075	COG3842	ATPase activity
LH89_18090	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
LH89_18095	COG0288	reversible hydration of carbon dioxide
LH89_18100	COG1131	(ABC) transporter
LH89_18105	COG0842	Transport permease protein
LH89_18110	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
LH89_18115	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
LH89_18120	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
LH89_18125	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
LH89_18130	COG0617	tRNA 3'-terminal CCA addition
LH89_18135	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
LH89_18140	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
LH89_18145	COG1489	DNA binding
LH89_18150	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
LH89_18155	COG1643	Atp-dependent helicase
LH89_18160	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
LH89_18165	COG1120	ATPase activity
LH89_18170	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
LH89_18175	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LH89_18195	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
LH89_18200	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
LH89_18205	COG0232	Belongs to the dGTPase family. Type 2 subfamily
LH89_18210	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
LH89_18215	COG3835	regulator
LH89_18220	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
LH89_18225	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
LH89_18230	COG4208	sulfate ABC transporter
LH89_18235	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
LH89_18265	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
LH89_18280	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
LH89_18285	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
LH89_18290	COG0513	Belongs to the DEAD box helicase family
LH89_18295	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
LH89_18300	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
LH89_18315	COG3026	antisigma factor binding
LH89_18320	COG3086	response to oxidative stress
LH89_18330	COG0481	GTPase activity
LH89_18335	COG0681	Belongs to the peptidase S26 family
LH89_18340	COG0571	ribonuclease III activity
LH89_18345	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
LH89_18350	COG1381	Involved in DNA repair and RecF pathway recombination
LH89_18355	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
LH89_18360	COG0736	holo-[acyl-carrier-protein] synthase activity
LH89_18365	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
LH89_18370	COG2200	EAL domain
LH89_18405	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
LH89_18410	COG0560	Phosphoserine phosphatase
LH89_18415	COG0590	tRNA wobble adenosine to inosine editing
LH89_18420	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
LH89_18425	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
LH89_18425	COG0047	phosphoribosylformylglycinamidine synthase activity
LH89_18430	COG2205	protein histidine kinase activity
LH89_18435	COG3170	Tfp pilus assembly protein FimV
LH89_18440	COG2204	response regulator
LH89_18445	COG0347	Belongs to the P(II) protein family
LH89_18450	COG4677	pectinesterase activity
LH89_18470	COG3866	Pectate lyase
LH89_18475	COG1017	nitric oxide dioxygenase activity
LH89_18475	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
LH89_18480	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
LH89_18485	COG2814	Major facilitator Superfamily
LH89_18490	COG3683	transport system, periplasmic component
LH89_18495	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
LH89_18505	COG1120	ATPase activity
LH89_18510	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LH89_18520	COG0483	inositol monophosphate 1-phosphatase activity
LH89_18525	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
LH89_18530	COG1959	2 iron, 2 sulfur cluster binding
LH89_18540	COG0822	iron-sulfur transferase activity
LH89_18545	COG0316	Belongs to the HesB IscA family
LH89_18550	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
LH89_18555	COG0443	Heat shock 70 kDa protein
LH89_18560	COG0633	Ferredoxin
LH89_18565	COG2975	iron-sulfur cluster assembly
LH89_18570	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
LH89_18580	COG2897	thiosulfate sulfurtransferase activity
LH89_18585	COG0105	UTP biosynthetic process
LH89_18590	COG0820	rRNA (adenine-C2-)-methyltransferase activity
LH89_18600	COG1426	Protein conserved in bacteria
LH89_18605	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
LH89_18610	COG0124	histidyl-tRNA synthetase
LH89_18615	COG2976	Protein conserved in bacteria
LH89_18620	COG1520	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
LH89_18625	COG1160	GTP binding
LH89_18645	COG1570	exodeoxyribonuclease VII activity
LH89_18650	COG0517	IMP dehydrogenase activity
LH89_18650	COG0516	GMP reductase activity
LH89_18655	COG0519	Catalyzes the synthesis of GMP from XMP
LH89_18655	COG0518	GMP synthase (glutamine-hydrolyzing) activity
LH89_18665	COG0583	DNA-binding transcription factor activity
LH89_18670	COG2814	Major facilitator Superfamily
LH89_18685	COG2207	Transcriptional regulator
LH89_18695	COG1902	pentaerythritol trinitrate reductase activity
LH89_18705	COG3007	enoyl-[acyl-carrier-protein] reductase (NADH) activity
LH89_18740	COG0477	Major facilitator Superfamily
LH89_18760	COG2814	Major facilitator Superfamily
LH89_18765	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
LH89_18770	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
LH89_18775	COG0351	phosphomethylpyrimidine kinase
LH89_18780	COG3223	Belongs to the PsiE family
LH89_18790	COG0435	Glutathione S-transferase
LH89_18795	COG0745	RESPONSE REGULATOR receiver
LH89_18800	COG2205	protein histidine kinase activity
LH89_18805	COG0477	Major facilitator Superfamily
LH89_18810	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LH89_18815	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LH89_18820	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LH89_18825	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
LH89_18830	COG0667	Aldo Keto reductase
LH89_18860	COG2885	chlorophyll binding
LH89_18860	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
LH89_18865	COG5404	Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1 1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division
LH89_18870	COG3070	regulator of competence-specific genes
LH89_18875	COG1289	transmembrane transporter activity
LH89_18880	COG3304	Inner membrane component domain
LH89_18885	COG0210	DNA helicase
LH89_18890	COG1803	Methylglyoxal synthase
LH89_18900	COG1832	CoA-binding protein
LH89_18905	COG3785	DNA binding
LH89_18910	COG1254	Belongs to the acylphosphatase family
LH89_18915	COG2920	part of a sulfur-relay system
LH89_18920	COG0670	Belongs to the BI1 family
LH89_18940	COG0589	response to stress
LH89_18945	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
LH89_18955	COG0248	Ppx GppA phosphatase
LH89_18960	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
LH89_18970	COG0581	inorganic phosphate transmembrane transporter activity
LH89_18975	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
LH89_18995	COG1760	l-serine dehydratase
LH89_19000	COG0814	amino acid
LH89_19005	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
LH89_19010	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
LH89_19015	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
LH89_19020	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
LH89_19030	COG0215	cysteine-tRNA ligase activity
LH89_19035	COG2501	S4 domain
LH89_19040	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
LH89_19045	COG0840	transmembrane signaling receptor activity
LH89_19060	COG0402	S-adenosylhomocysteine deaminase activity
LH89_19090	COG2986	histidine ammonia-lyase
LH89_19095	COG4565	transcriptional regulatory protein
LH89_19100	COG3290	protein histidine kinase activity
LH89_19145	COG2986	histidine ammonia-lyase
LH89_19150	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
LH89_19175	COG5297	Belongs to the glycosyl hydrolase family 6
LH89_19185	COG1473	amidohydrolase
LH89_19195	COG2182	Extracellular solute-binding protein
LH89_19200	COG1175	transmembrane transport
LH89_19205	COG3833	ABC-type maltose transport systems, permease component
LH89_19215	COG1874	Beta-galactosidase
LH89_19220	COG1263	PTS System
LH89_19220	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LH89_19235	COG0583	DNA-binding transcription factor activity
LH89_19250	COG0446	pyridine nucleotide-disulphide oxidoreductase
LH89_19260	COG2850	peptidyl-arginine hydroxylation
LH89_19280	COG0583	DNA-binding transcription factor activity
LH89_19290	COG3264	Mechanosensitive ion channel
LH89_19290	COG1511	domain protein
LH89_19295	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
LH89_19300	COG0436	Aminotransferase
LH89_19310	COG3266	domain, Protein
LH89_19315	COG3031	protein transport across the cell outer membrane
LH89_19320	COG1450	Type ii and iii secretion system protein
LH89_19385	COG1902	pentaerythritol trinitrate reductase activity
LH89_19390	COG2050	protein possibly involved in aromatic compounds catabolism
LH89_19395	COG1028	Short-chain dehydrogenase reductase Sdr
LH89_19400	COG3433	isochorismatase activity
LH89_19400	COG1535	isochorismatase
LH89_19405	COG1021	2,3-dihydroxybenzoate-AMP ligase
LH89_19410	COG1169	isochorismate synthase
LH89_19415	COG4774	siderophore transport
LH89_19420	COG2382	esterase
LH89_19435	COG1120	ATPase activity
LH89_19440	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LH89_19445	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
LH89_19455	COG4592	Periplasmic binding protein
LH89_19470	COG2503	HAD superfamily, subfamily IIIB (Acid phosphatase)
LH89_19490	COG0579	oxidoreductase
LH89_19495	COG2067	long-chain fatty acid transport protein
LH89_19500	COG3691	Protein conserved in bacteria
LH89_19505	COG0183	Belongs to the thiolase family
LH89_19510	COG1024	Enoyl-CoA hydratase
LH89_19510	COG1250	3-hydroxyacyl-CoA dehydrogenase
LH89_19515	COG2062	phosphohistidine phosphatase, SixA
LH89_19520	COG2840	Smr protein MutS2
LH89_19525	COG2890	protein-(glutamine-N5) methyltransferase activity
LH89_19530	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
LH89_19535	COG3770	Murein endopeptidase that cleaves the D-alanyl-meso-2,6- diamino-pimelyl amide bond that connects peptidoglycan strands. Likely plays a role in the removal of murein from the sacculus
LH89_19540	COG0730	response to heat
LH89_19545	COG3101	peptidyl-lysine hydroxylation
LH89_19575	COG1764	response to oxidative stress
LH89_19595	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
LH89_19595	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
LH89_19600	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
LH89_19635	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
LH89_19640	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
LH89_19645	COG0101	tRNA pseudouridine synthase activity
LH89_19650	COG0586	Pfam SNARE associated Golgi protein
LH89_19655	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
LH89_19660	COG0285	dihydrofolate synthase activity
LH89_19665	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
LH89_19670	COG1286	toxin biosynthetic process
LH89_19675	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
LH89_19680	COG0163	prenyltransferase activity
LH89_19685	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
LH89_19690	COG4215	(ABC) transporter
LH89_19695	COG4160	amino acid transport
LH89_19705	COG1090	epimerase
LH89_19710	COG0625	glutathione transferase activity
LH89_19715	COG0622	Phosphoesterase
LH89_19725	COG0857	belongs to the CobB CobQ family
LH89_19725	COG0280	phosphate acetyltransferase
LH89_19730	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
LH89_19735	COG3092	negative regulation of chromosome organization
LH89_19740	COG3013	Belongs to the UPF0304 family
LH89_19745	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
LH89_19750	COG0490	domain, Protein
LH89_19750	COG0471	metal ion transport
LH89_19755	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
LH89_19760	COG0436	Aminotransferase
LH89_19765	COG0583	DNA-binding transcription factor activity
LH89_19770	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LH89_19780	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LH89_19780	COG0649	NAD binding
LH89_19785	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
LH89_19790	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
LH89_19795	COG1034	ATP synthesis coupled electron transport
LH89_19800	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
LH89_19805	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LH89_19810	COG0839	Belongs to the complex I subunit 6 family
LH89_19815	COG0713	ATP synthesis coupled electron transport
LH89_19820	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
LH89_19825	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
LH89_19830	COG1007	ATP synthesis coupled electron transport
LH89_19835	COG2132	Multicopper oxidase
LH89_19845	COG0384	phenazine biosynthesis protein PhzF
LH89_19850	COG0488	(ABC) transporter
LH89_19855	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
LH89_19860	COG0437	4 iron, 4 sulfur cluster binding
LH89_19865	COG5557	Pfam Polysulphide reductase, NrfD
LH89_19870	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
LH89_19875	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
LH89_19880	COG1773	rubredoxin
LH89_19885	COG0375	protein maturation
LH89_19895	COG0298	carbon dioxide binding
LH89_19900	COG0409	Hydrogenase expression formation protein
LH89_19905	COG0309	Hydrogenase expression formation protein (HypE)
LH89_19910	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
LH89_19920	COG0518	GMP synthase (glutamine-hydrolyzing) activity
LH89_19920	COG0519	Catalyzes the synthesis of GMP from XMP
LH89_19925	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
LH89_19930	COG3383	formate dehydrogenase (NAD+) activity
LH89_19930	COG0243	molybdopterin cofactor binding
LH89_19935	COG0437	4 iron, 4 sulfur cluster binding
LH89_19940	COG2864	formate dehydrogenase
LH89_19945	COG2271	Major facilitator Superfamily
LH89_19950	COG3058	Necessary for formate dehydrogenase activity
LH89_19960	COG2814	Major facilitator Superfamily
LH89_19970	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
LH89_19975	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
LH89_19980	COG1538	Outer membrane efflux protein
LH89_19990	COG3707	response regulator
LH89_19995	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
LH89_20005	COG1116	anion transmembrane transporter activity
LH89_20010	COG2146	nitrite reductase [NAD(P)H] activity
LH89_20010	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
LH89_20015	COG0243	molybdopterin cofactor binding
LH89_20020	COG1648	precorrin-2 dehydrogenase activity
LH89_20020	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
LH89_20045	COG0436	Aminotransferase
LH89_20050	COG0583	DNA-binding transcription factor activity
LH89_20055	COG1619	proteins homologs of microcin C7 resistance protein MccF
LH89_20065	COG0840	transmembrane signaling receptor activity
LH89_20075	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
LH89_20080	COG1819	glycosyl
LH89_20095	COG2205	protein histidine kinase activity
LH89_20115	COG2963	transposase activity
LH89_20130	COG4227	nucleotidyltransferase activity
LH89_20160	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
LH89_20170	COG3504	Conjugal transfer protein
LH89_20175	COG3736	Type IV secretory pathway, component VirB8
LH89_20230	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
LH89_20250	COG3423	Transcriptional regulator
LH89_20265	COG0582	viral genome integration into host DNA
LH89_20280	COG1113	amino acid transport
LH89_20295	COG2197	response regulator
LH89_20300	COG0322	excinuclease ABC activity
LH89_20305	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
LH89_20335	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
LH89_20350	COG1396	sequence-specific DNA binding
LH89_20375	COG1484	DNA-dependent DNA replication
LH89_20380	COG0305	Participates in initiation and elongation during chromosome replication
LH89_20450	COG3179	chitinase
LH89_20625	COG4733	cellulase activity
LH89_20630	COG2730	Belongs to the glycosyl hydrolase 5 (cellulase A) family
LH89_20640	COG0534	Mate efflux family protein
LH89_20660	COG0840	transmembrane signaling receptor activity
LH89_20665	COG1979	alcohol dehydrogenase
LH89_20690	COG1360	Flagellar Motor Protein
LH89_20695	COG2198	Histidine kinase
LH89_20695	COG0643	Histidine kinase
LH89_20700	COG0835	chemotaxis
LH89_20705	COG0840	transmembrane signaling receptor activity
LH89_20715	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
LH89_20720	COG2201	protein-glutamate methylesterase activity
LH89_20725	COG0745	RESPONSE REGULATOR receiver
LH89_20730	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
LH89_20735	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
LH89_20740	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
LH89_20755	COG2747	anti-sigma28 factor FlgM
LH89_20765	COG1815	bacterial-type flagellum-dependent cell motility
LH89_20770	COG1558	bacterial-type flagellum-dependent cell motility
LH89_20775	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
LH89_20780	COG1749	Flagellar hook protein flgE
LH89_20785	COG4787	bacterial-type flagellum-dependent cell motility
LH89_20790	COG4786	Flagellar basal body rod
LH89_20795	COG2063	Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation
LH89_20800	COG1706	bacterial-type flagellum-dependent cell motility
LH89_20810	COG1256	bacterial-type flagellum assembly
LH89_20815	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
LH89_20850	COG1580	Controls the rotational direction of flagella during chemotaxis
LH89_20860	COG2882	bacterial-type flagellum organization
LH89_20865	COG1157	protein secretion by the type III secretion system
LH89_20870	COG1317	bacterial-type flagellum organization
LH89_20875	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
LH89_20885	COG1677	Flagellar hook-basal body complex protein FliE
LH89_20900	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
LH89_20910	COG0500	methyltransferase
LH89_20925	COG0673	inositol 2-dehydrogenase activity
LH89_20935	COG1191	sigma factor activity
LH89_20945	COG1702	phosphate starvation-inducible protein PhoH
LH89_20975	COG1012	belongs to the aldehyde dehydrogenase family
LH89_20985	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
LH89_20990	COG1067	ATP-dependent peptidase activity
LH89_21010	COG0840	transmembrane signaling receptor activity
LH89_21020	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
LH89_21025	COG2943	transferase activity, transferring hexosyl groups
LH89_21030	COG2814	Major facilitator Superfamily
LH89_21035	COG1560	Kdo2-lipid A biosynthetic process
LH89_21050	COG2353	YceI-like domain
LH89_21055	COG3038	cytochrome b561
LH89_21070	COG0418	dihydroorotase activity
LH89_21080	COG1530	ribonuclease E activity
LH89_21085	COG0564	pseudouridine synthase activity
LH89_21090	COG0424	maF-like protein
LH89_21095	COG1399	metal-binding, possibly nucleic acid-binding protein
LH89_21100	COG0333	Belongs to the bacterial ribosomal protein bL32 family
LH89_21105	COG0416	fatty acid biosynthetic process
LH89_21110	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
LH89_21115	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
LH89_21120	COG1028	Short-chain dehydrogenase reductase Sdr
LH89_21125	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
LH89_21130	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
LH89_21135	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
LH89_21140	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
LH89_21145	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
LH89_21150	COG0470	DNA polymerase III
LH89_21155	COG0084	hydrolase, TatD family'
LH89_21160	COG1263	PTS System
LH89_21160	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
LH89_21165	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
LH89_21170	COG0537	adenosine 5'-monophosphoramidase activity
LH89_21175	COG5633	Lipoprotein
LH89_21180	COG3417	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)
LH89_21190	COG1472	Belongs to the glycosyl hydrolase 3 family
LH89_21200	COG1252	NADH dehydrogenase
LH89_21205	COG3134	Outer membrane lipoprotein
LH89_21210	COG1609	Transcriptional regulator
LH89_21215	COG2271	Major facilitator Superfamily
LH89_21230	COG0443	Heat shock 70 kDa protein
LH89_21235	COG2200	EAL domain
LH89_21240	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
LH89_21245	COG4591	ABC-type transport system involved in lipoprotein release permease component
LH89_21250	COG1136	(ABC) transporter
LH89_21255	COG4591	ABC-type transport system involved in lipoprotein release permease component
LH89_21265	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
LH89_21275	COG4139	cobalamin transport
LH89_21280	COG0386	Belongs to the glutathione peroxidase family
LH89_21285	COG4138	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system
LH89_21290	COG0791	NLP P60 protein
LH89_21295	COG0095	Lipoate-protein ligase
LH89_21305	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
LH89_21310	COG2989	Protein conserved in bacteria
LH89_21315	COG3108	Peptidase M15
LH89_21320	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
LH89_21325	COG1448	Aminotransferase
LH89_21340	COG0017	Asparaginyl-tRNA synthetase
LH89_21345	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
LH89_21350	COG0308	aminopeptidase N
LH89_21355	COG1116	anion transmembrane transporter activity
LH89_21360	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
LH89_21365	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
LH89_21370	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
LH89_21375	COG0431	NADPH-dependent FMN reductase
LH89_21380	COG0167	dihydroorotate dehydrogenase activity
LH89_21390	COG0633	Ferredoxin
LH89_21390	COG3217	Mosc domain protein beta barrel domain protein
LH89_21395	COG0116	Belongs to the methyltransferase superfamily
LH89_21395	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
LH89_21400	COG0488	(ABC) transporter
LH89_21405	COG2995	paraquat-inducible protein a
LH89_21410	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
LH89_21410	COG3008	intermembrane lipid transfer
LH89_21415	COG3009	Protein conserved in bacteria
LH89_21420	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
LH89_21425	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
LH89_21435	COG0574	Belongs to the PEP-utilizing enzyme family
LH89_21435	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
LH89_21440	COG0628	permease
LH89_21445	COG0247	lactate metabolic process
LH89_21445	COG0277	FAD linked oxidase domain protein
LH89_21450	COG2050	protein possibly involved in aromatic compounds catabolism
LH89_21460	COG0316	Belongs to the HesB IscA family
LH89_21465	COG0719	Fe-S assembly protein
LH89_21470	COG0396	ATPase activity
LH89_21475	COG0719	Fe-S assembly protein
LH89_21480	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
LH89_21485	COG2166	iron-sulfur cluster assembly
LH89_21490	COG1376	ErfK ybiS ycfS ynhG family protein
LH89_21490	COG1388	LysM domain
LH89_21495	COG4238	major outer membrane lipoprotein
LH89_21510	COG0583	DNA-binding transcription factor activity
LH89_21515	COG1902	pentaerythritol trinitrate reductase activity
LH89_21545	COG1522	sequence-specific DNA binding
LH89_21570	COG2382	esterase
LH89_21580	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
LH89_21580	COG1028	Short-chain dehydrogenase reductase Sdr
LH89_21580	COG3321	synthase
LH89_21580	COG4221	oxidoreductase activity
LH89_21590	COG0156	8-amino-7-oxononanoate synthase activity
LH89_21615	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
LH89_21630	COG0534	Mate efflux family protein
LH89_21640	COG4615	Cyclic peptide transporter
LH89_21665	COG0583	DNA-binding transcription factor activity
LH89_21675	COG0583	DNA-binding transcription factor activity
LH89_21680	COG1942	4-Oxalocrotonate Tautomerase
LH89_21685	COG1794	racemase activity, acting on amino acids and derivatives
LH89_21710	COG0534	Mate efflux family protein
LH89_21715	COG0307	riboflavin synthase, alpha
LH89_21720	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
LH89_21725	COG1609	Transcriptional regulator
LH89_21735	COG0791	NLP P60 protein
LH89_21740	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
LH89_21745	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
LH89_21750	COG0346	lactoylglutathione lyase activity
LH89_21765	COG3133	Outer membrane lipoprotein
LH89_21770	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
LH89_21775	COG3895	Periplasmic Protein
LH89_21790	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
LH89_21795	COG0625	glutathione transferase activity
LH89_21815	COG0671	phosphoesterase, PA-phosphatase related
LH89_21820	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
LH89_21825	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
LH89_21840	COG0023	Translation Initiation Factor
LH89_21860	COG1966	Carbon starvation protein
LH89_21865	COG4989	oxidoreductase activity
LH89_21870	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
LH89_21875	COG0243	molybdopterin cofactor binding
LH89_21880	COG0583	DNA-binding transcription factor activity
LH89_21895	COG4172	Belongs to the ABC transporter superfamily
LH89_21900	COG4171	peptide transport system, permease
LH89_21905	COG4168	peptide transport system, permease
LH89_21910	COG4166	transmembrane transport
LH89_21930	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
LH89_21935	COG1842	Phage shock protein A
LH89_21945	COG1983	PspC domain protein
LH89_21955	COG3106	COG3106 Predicted ATPase
LH89_21960	COG3768	UPF0283 membrane protein
LH89_21980	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
LH89_21990	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
LH89_22005	COG0477	Major facilitator Superfamily
LH89_22010	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
LH89_22015	COG2866	Carboxypeptidase
LH89_22020	COG4166	transmembrane transport
LH89_22025	COG0598	Magnesium transport protein CorA
LH89_22030	COG0037	tRNA processing
LH89_22070	COG0840	transmembrane signaling receptor activity
LH89_22080	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
LH89_22085	COG0840	transmembrane signaling receptor activity
LH89_22090	COG2911	Protein conserved in bacteria
LH89_22100	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
LH89_22105	COG1643	Atp-dependent helicase
LH89_22110	COG3591	Belongs to the peptidase S1B family
LH89_22125	COG2205	protein histidine kinase activity
LH89_22130	COG0745	RESPONSE REGULATOR receiver
LH89_22140	COG0659	secondary active sulfate transmembrane transporter activity
LH89_22145	COG0387	Pfam Sodium calcium exchanger
LH89_22150	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
LH89_22155	COG0601	transmembrane transport
LH89_22160	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
LH89_22165	COG0444	Belongs to the ABC transporter superfamily
LH89_22170	COG4608	Belongs to the ABC transporter superfamily
LH89_22180	COG0038	chloride channel
LH89_22185	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
LH89_22195	COG0840	transmembrane signaling receptor activity
LH89_22200	COG0840	transmembrane signaling receptor activity
LH89_22210	COG0402	S-adenosylhomocysteine deaminase activity
LH89_22260	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
LH89_22280	COG2840	Smr protein MutS2