locus-tag	class	description
skT53_00010	COG5002	protein histidine kinase activity
skT53_00050	COG2200	EAL domain
skT53_00050	COG2771	luxR family
skT53_00090	COG1366	Belongs to the anti-sigma-factor antagonist family
skT53_00100	COG0302	gtp cyclohydrolase
skT53_00120	COG0300	oxidoreductase activity
skT53_00180	COG2030	dehydratase
skT53_00210	COG1657	PFAM Prenyltransferase squalene oxidase
skT53_00250	COG2226	methyltransferase
skT53_00260	COG1028	Short-chain dehydrogenase reductase Sdr
skT53_00280	COG0730	response to heat
skT53_00290	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
skT53_00290	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
skT53_00300	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
skT53_00320	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
skT53_00330	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
skT53_00330	COG1648	precorrin-2 dehydrogenase activity
skT53_00340	COG0181	hydroxymethylbilane synthase activity
skT53_00350	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
skT53_00350	COG1587	Uroporphyrinogen-III synthase
skT53_00360	COG0113	porphobilinogen synthase activity
skT53_00370	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
skT53_00410	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
skT53_00490	COG0285	dihydrofolate synthase activity
skT53_00500	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
skT53_00510	COG3583	domain protein
skT53_00510	COG3584	3D domain protein
skT53_00530	COG1027	Aspartate ammonia-lyase
skT53_00560	COG0424	maF-like protein
skT53_00570	COG2003	Belongs to the UPF0758 family
skT53_00580	COG1077	Cell shape determining protein MreB Mrl
skT53_00590	COG1792	Involved in formation and maintenance of cell shape
skT53_00610	COG0768	penicillin binding
skT53_00620	COG0850	regulation of cytokinetic process
skT53_00630	COG2894	cell division
skT53_00640	COG0772	Belongs to the SEDS family
skT53_00690	COG2267	carboxylic ester hydrolase activity
skT53_00710	COG0791	NLP P60 protein
skT53_00710	COG1388	LysM domain
skT53_00770	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
skT53_00800	COG0022	dehydrogenase e1 component
skT53_00860	COG0840	transmembrane signaling receptor activity
skT53_00890	COG4555	ABC transporter
skT53_00910	COG1293	RNA-binding protein homologous to eukaryotic snRNP
skT53_00920	COG2814	Major facilitator Superfamily
skT53_00940	COG3973	AAA domain
skT53_00950	COG0697	spore germination
skT53_00960	COG0697	spore germination
skT53_00990	COG3123	guanosine phosphorylase activity
skT53_01000	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
skT53_01020	COG1561	YicC-like family, N-terminal region
skT53_01030	COG2052	Domain of unknown function (DUF370)
skT53_01040	COG0194	GDP metabolic process
skT53_01050	COG1758	RNA polymerase activity
skT53_01060	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
skT53_01070	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
skT53_01080	COG0242	peptide deformylase activity
skT53_01100	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
skT53_01100	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
skT53_01110	COG0820	rRNA (adenine-C2-)-methyltransferase activity
skT53_01120	COG0631	protein serine/threonine phosphatase activity
skT53_01130	COG2815	serine threonine protein kinase
skT53_01130	COG0515	serine threonine protein kinase
skT53_01140	COG1162	GTPase activity
skT53_01150	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
skT53_01160	COG0227	Belongs to the bacterial ribosomal protein bL28 family
skT53_01170	COG1302	Protein conserved in bacteria
skT53_01180	COG1461	Dihydroxyacetone kinase
skT53_01190	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
skT53_01210	COG0742	ribosomal rna small subunit methyltransferase
skT53_01220	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
skT53_01230	COG1752	Esterase of the alpha-beta hydrolase superfamily
skT53_01240	COG3480	Lon protease (S16) C-terminal proteolytic domain
skT53_01250	COG1323	Belongs to the UPF0348 family
skT53_01270	COG0333	Belongs to the bacterial ribosomal protein bL32 family
skT53_01320	COG1597	lipid kinase activity
skT53_01340	COG0416	fatty acid biosynthetic process
skT53_01350	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
skT53_01360	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
skT53_01370	COG1028	Short-chain dehydrogenase reductase Sdr
skT53_01380	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
skT53_01390	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
skT53_01400	COG0571	ribonuclease III activity
skT53_01430	COG0745	RESPONSE REGULATOR receiver
skT53_01440	COG5002	protein histidine kinase activity
skT53_01450	COG1196	nuclear chromosome segregation
skT53_01460	COG0552	protein localization to endoplasmic reticulum
skT53_01470	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
skT53_01480	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
skT53_01490	COG0228	four-way junction DNA binding
skT53_01500	COG1837	Belongs to the UPF0109 family
skT53_01510	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
skT53_01520	COG0336	Belongs to the RNA methyltransferase TrmD family
skT53_01540	COG1960	acyl-CoA dehydrogenase activity
skT53_01650	COG2223	nitrite transmembrane transporter activity
skT53_01670	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
skT53_01680	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
skT53_01690	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
skT53_01700	COG1140	nitrate reductase beta subunit
skT53_01710	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
skT53_01720	COG2181	nitrate reductase activity
skT53_01730	COG0535	radical SAM domain protein
skT53_01740	COG4585	Histidine kinase
skT53_01750	COG2197	response regulator
skT53_01760	COG0243	molybdopterin cofactor binding
skT53_01770	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
skT53_01780	COG2146	nitrite reductase [NAD(P)H] activity
skT53_01790	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
skT53_01800	COG0789	Transcriptional regulator
skT53_01830	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
skT53_01850	COG0010	Belongs to the arginase family
skT53_01890	COG1122	ATPase activity
skT53_01900	COG0831	urea catabolic process
skT53_01910	COG0804	urea catabolic process
skT53_01930	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
skT53_02000	COG1028	Short-chain dehydrogenase reductase Sdr
skT53_02010	COG2814	Major facilitator Superfamily
skT53_02040	COG0347	Belongs to the P(II) protein family
skT53_02050	COG2223	nitrite transmembrane transporter activity
skT53_02070	COG0004	ammonium transporteR
skT53_02080	COG1285	pathogenesis
skT53_02130	COG0335	large ribosomal subunit rRNA binding
skT53_02160	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
skT53_02180	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
skT53_02230	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
skT53_02240	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
skT53_02250	COG1120	ATPase activity
skT53_02270	COG0606	chelatase, subunit chli
skT53_02300	COG0778	Nitroreductase
skT53_02320	COG0045	succinate-CoA ligase (ADP-forming) activity
skT53_02330	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
skT53_02340	COG0758	DNA mediated transformation
skT53_02350	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
skT53_02360	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
skT53_02370	COG4974	Belongs to the 'phage' integrase family
skT53_02380	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
skT53_02390	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
skT53_02400	COG1815	bacterial-type flagellum-dependent cell motility
skT53_02420	COG1677	Flagellar hook-basal body complex protein FliE
skT53_02430	COG1766	The M ring may be actively involved in energy transduction
skT53_02440	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
skT53_02460	COG1157	protein secretion by the type III secretion system
skT53_02500	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
skT53_02520	COG4786	Flagellar basal body rod
skT53_02550	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
skT53_02560	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
skT53_02560	COG1776	CheC inhibitor of MCP methylation
skT53_02570	COG2201	protein-glutamate methylesterase activity
skT53_02590	COG1338	Plays a role in the flagellum-specific transport system
skT53_02600	COG1987	bacterial-type flagellum assembly
skT53_02610	COG1684	flagellar biosynthetic protein fliR
skT53_02620	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
skT53_02630	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
skT53_02640	COG1419	protein localization to endoplasmic reticulum
skT53_02650	COG0455	bacterial-type flagellum organization
skT53_02660	COG2201	protein-glutamate methylesterase activity
skT53_02670	COG0643	Histidine kinase
skT53_02670	COG2198	Histidine kinase
skT53_02690	COG1776	CheC inhibitor of MCP methylation
skT53_02700	COG1871	Probably deamidates glutamine residues to glutamate on methyl-accepting chemotaxis receptors (MCPs), playing an important role in chemotaxis
skT53_02720	COG1191	sigma factor activity
skT53_02770	COG0052	Belongs to the universal ribosomal protein uS2 family
skT53_02780	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
skT53_02790	COG0528	UMP kinase activity
skT53_02800	COG0233	cytoplasmic translational termination
skT53_02810	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
skT53_02820	COG4589	Belongs to the CDS family
skT53_02840	COG0442	prolyl-tRNA aminoacylation
skT53_02860	COG2176	DNA-directed DNA polymerase activity
skT53_02870	COG0779	Required for maturation of 30S ribosomal subunits
skT53_02880	COG0195	Participates in both transcription termination and antitermination
skT53_02890	COG2740	Nucleic-acid-binding protein implicated in transcription termination
skT53_02910	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
skT53_02930	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
skT53_02940	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
skT53_02950	COG0196	riboflavin kinase activity
skT53_02980	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
skT53_02990	COG1185	polyribonucleotide nucleotidyltransferase activity
skT53_03000	COG0726	polysaccharide deacetylase
skT53_03010	COG0612	Peptidase, M16
skT53_03020	COG0756	dUTP diphosphatase activity
skT53_03040	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
skT53_03050	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
skT53_03060	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
skT53_03070	COG0527	aspartate kinase activity
skT53_03080	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
skT53_03090	COG0595	An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and or decay
skT53_03130	COG0740	serine-type endopeptidase activity
skT53_03150	COG1674	ftsk spoiiie
skT53_03150	COG4980	gas vesicle protein
skT53_03160	COG1285	pathogenesis
skT53_03190	COG0067	glutamate synthase
skT53_03190	COG0070	glutamate synthase
skT53_03190	COG0069	glutamate synthase activity
skT53_03200	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
skT53_03230	COG0300	oxidoreductase activity
skT53_03250	COG1278	Cold shock
skT53_03260	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
skT53_03270	COG0302	gtp cyclohydrolase
skT53_03290	COG3091	SprT-like family
skT53_03320	COG0210	DNA helicase
skT53_03330	COG1609	Transcriptional regulator
skT53_03340	COG4862	establishment of competence for transformation
skT53_03350	COG2707	UPF0756 membrane protein
skT53_03360	COG1809	phosphosulfolactate synthase activity
skT53_03370	COG2814	Major facilitator Superfamily
skT53_03380	COG0626	cystathionine gamma-synthase activity
skT53_03390	COG0626	cystathionine gamma-synthase activity
skT53_03400	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
skT53_03410	COG0252	asparaginase activity
skT53_03440	COG2959	enzyme of heme biosynthesis
skT53_03450	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
skT53_03470	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
skT53_03490	COG0539	negative regulation of cytoplasmic translation
skT53_03500	COG1304	FMN binding
skT53_03550	COG1160	GTP binding
skT53_03560	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
skT53_03570	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
skT53_03580	COG0509	glycine decarboxylation via glycine cleavage system
skT53_03590	COG0095	Lipoate-protein ligase
skT53_03600	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
skT53_03620	COG0776	regulation of translation
skT53_03650	COG1842	Phage shock protein A
skT53_03700	COG2226	methyltransferase
skT53_03710	COG0142	geranyltranstransferase activity
skT53_03720	COG0105	UTP biosynthetic process
skT53_03730	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
skT53_03740	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
skT53_03760	COG0564	pseudouridine synthase activity
skT53_03810	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
skT53_03820	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
skT53_03830	COG4401	Chorismate mutase type I
skT53_03840	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
skT53_03850	COG0134	indole-3-glycerol-phosphate synthase activity
skT53_03860	COG0135	phosphoribosylanthranilate isomerase activity
skT53_03880	COG0159	tryptophan synthase activity
skT53_03890	COG0287	Prephenate dehydrogenase
skT53_03900	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
skT53_03920	COG1061	Type III restriction enzyme res subunit
skT53_03940	COG5582	Belongs to the UPF0302 family
skT53_03990	COG4347	Protein of unknown function (DUF1405)
skT53_04000	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
skT53_04010	COG0586	Pfam SNARE associated Golgi protein
skT53_04020	COG3949	Membrane
skT53_04030	COG1968	undecaprenyl-diphosphatase activity
skT53_04040	COG3314	Sporulation integral membrane protein YlbJ
skT53_04050	COG1694	Mazg nucleotide pyrophosphohydrolase
skT53_04060	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
skT53_04070	COG0617	tRNA 3'-terminal CCA addition
skT53_04090	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
skT53_04100	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
skT53_04110	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
skT53_04130	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
skT53_04130	COG1199	ATP-dependent helicase activity
skT53_04150	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
skT53_04160	COG3285	dna ligase
skT53_04160	COG1793	dna ligase
skT53_04170	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
skT53_04190	COG0235	Class ii aldolase
skT53_04200	COG0402	S-adenosylhomocysteine deaminase activity
skT53_04250	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
skT53_04290	COG1028	Short-chain dehydrogenase reductase Sdr
skT53_04310	COG0183	Belongs to the thiolase family
skT53_04320	COG1028	Short-chain dehydrogenase reductase Sdr
skT53_04330	COG1960	acyl-CoA dehydrogenase activity
skT53_04340	COG2030	dehydratase
skT53_04380	COG0318	PFAM AMP-dependent synthetase and ligase
skT53_04470	COG0657	acetylesterase activity
skT53_04490	COG2181	nitrate reductase activity
skT53_04490	COG0247	lactate metabolic process
skT53_04500	COG2130	NADP-dependent
skT53_04520	COG1902	pentaerythritol trinitrate reductase activity
skT53_04570	COG1683	Conserved Protein
skT53_04620	COG0318	PFAM AMP-dependent synthetase and ligase
skT53_04630	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
skT53_04680	COG0559	Belongs to the binding-protein-dependent transport system permease family
skT53_04720	COG0318	PFAM AMP-dependent synthetase and ligase
skT53_04750	COG1024	Enoyl-CoA hydratase
skT53_04760	COG1804	L-carnitine dehydratase bile acid-inducible protein F
skT53_04780	COG3622	Belongs to the hyi family
skT53_04790	COG2084	Dehydrogenase
skT53_04800	COG0247	lactate metabolic process
skT53_04810	COG1139	Iron-sulfur cluster binding protein
skT53_04820	COG1556	Lactate utilization protein
skT53_04830	COG0667	Aldo Keto reductase
skT53_04880	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
skT53_04890	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
skT53_04900	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
skT53_04910	COG0488	(ABC) transporter
skT53_04930	COG0488	(ABC) transporter
skT53_04970	COG1960	acyl-CoA dehydrogenase activity
skT53_04980	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
skT53_04990	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
skT53_05040	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
skT53_05050	COG0444	Belongs to the ABC transporter superfamily
skT53_05060	COG4608	Belongs to the ABC transporter superfamily
skT53_05070	COG0318	PFAM AMP-dependent synthetase and ligase
skT53_05100	COG0450	alkyl hydroperoxide reductase
skT53_05140	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
skT53_05150	COG2011	ABC-type metal ion transport system permease component
skT53_05160	COG1464	Belongs to the NlpA lipoprotein family
skT53_05170	COG2271	Major facilitator Superfamily
skT53_05190	COG3773	Cell wall hydrolase
skT53_05200	COG1012	belongs to the aldehyde dehydrogenase family
skT53_05210	COG1063	alcohol dehydrogenase
skT53_05240	COG3829	transcription factor binding
skT53_05250	COG0154	amidase activity
skT53_05310	COG0154	amidase activity
skT53_05330	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
skT53_05390	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
skT53_05410	COG3627	carbon phosphorus lyase activity
skT53_05420	COG3627	carbon phosphorus lyase activity
skT53_05430	COG4107	phosphonate C-P lyase system protein PhnK
skT53_05450	COG1116	anion transmembrane transporter activity
skT53_05470	COG3454	Phosphonate metabolism
skT53_05480	COG0613	PHP domain protein
skT53_05510	COG1968	undecaprenyl-diphosphatase activity
skT53_05530	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
skT53_05610	COG0248	Ppx GppA phosphatase
skT53_05620	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
skT53_05630	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
skT53_05640	COG1028	Short-chain dehydrogenase reductase Sdr
skT53_05790	COG2972	Histidine kinase
skT53_05800	COG2204	response regulator
skT53_05810	COG2855	membrane
skT53_05820	COG2855	membrane
skT53_05840	COG2721	sulfolactate sulfo-lyase activity
skT53_05850	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
skT53_05860	COG2186	Transcriptional regulator
skT53_05870	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
skT53_05880	COG2271	Major facilitator Superfamily
skT53_05900	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
skT53_05940	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
skT53_05950	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
skT53_05950	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
skT53_05960	COG1960	acyl-CoA dehydrogenase activity
skT53_05970	COG1960	acyl-CoA dehydrogenase activity
skT53_05980	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
skT53_05980	COG1042	CoA-binding domain protein
skT53_05980	COG0045	succinate-CoA ligase (ADP-forming) activity
skT53_06000	COG1024	Enoyl-CoA hydratase
skT53_06070	COG1012	belongs to the aldehyde dehydrogenase family
skT53_06080	COG1960	acyl-CoA dehydrogenase activity
skT53_06090	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
skT53_06100	COG4670	ketone body catabolic process
skT53_06120	COG1024	Enoyl-CoA hydratase
skT53_06130	COG1802	Transcriptional regulator
skT53_06140	COG0860	N-Acetylmuramoyl-L-alanine amidase
skT53_06150	COG0805	protein transport
skT53_06160	COG1971	Probably functions as a manganese efflux pump
skT53_06230	COG1802	Transcriptional regulator
skT53_06240	COG1012	belongs to the aldehyde dehydrogenase family
skT53_06250	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
skT53_06260	COG0431	NADPH-dependent FMN reductase
skT53_06270	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
skT53_06290	COG3359	exonuclease
skT53_06300	COG1205	dead DEAH box helicase
skT53_06300	COG1111	helicase
skT53_06310	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
skT53_06330	COG0604	alcohol dehydrogenase
skT53_06330	COG3321	synthase
skT53_06340	COG0179	Fumarylacetoacetate (FAA) hydrolase
skT53_06490	COG1695	Transcriptional regulator
skT53_06580	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
skT53_06620	COG1482	cell wall glycoprotein biosynthetic process
skT53_06640	COG1940	carbohydrate kinase activity
skT53_06650	COG0010	Belongs to the arginase family
skT53_06680	COG1376	ErfK ybiS ycfS ynhG family protein
skT53_06710	COG2271	Major facilitator Superfamily
skT53_06720	COG0840	transmembrane signaling receptor activity
skT53_06810	COG2271	Major facilitator Superfamily
skT53_06820	COG2186	Transcriptional regulator
skT53_06840	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
skT53_06840	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
skT53_06850	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
skT53_06850	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
skT53_06860	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
skT53_06900	COG2855	membrane
skT53_06910	COG0039	L-malate dehydrogenase activity
skT53_06920	COG2837	iron assimilation
skT53_06930	COG2822	iron ion transport
skT53_06940	COG1279	arginine transmembrane transporter activity
skT53_06960	COG0521	Mo-molybdopterin cofactor biosynthetic process
skT53_06970	COG2839	Protein conserved in bacteria
skT53_06990	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
skT53_07000	COG0174	glutamine synthetase
skT53_07020	COG0789	Transcriptional regulator
skT53_07030	COG0174	glutamine synthetase
skT53_07040	COG4100	CystaTHIonine beta-lyase family protein involved in aluminum resistance
skT53_07050	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
skT53_07080	COG0464	growth
skT53_07090	COG1141	Ferredoxin
skT53_07100	COG1923	regulation of RNA biosynthetic process
skT53_07120	COG2136	Putative SAM-dependent methyltransferase
skT53_07120	COG2521	methyltransferase
skT53_07130	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
skT53_07140	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
skT53_07150	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
skT53_07210	COG0189	ligase activity
skT53_07240	COG1234	tRNA 3'-trailer cleavage
skT53_07270	COG2359	stage V sporulation protein S
skT53_07280	COG1692	metallophosphoesterase
skT53_07300	COG1418	mRNA catabolic process
skT53_07310	COG2137	regulation of response to DNA damage stimulus
skT53_07320	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
skT53_07330	COG0513	Belongs to the DEAD box helicase family
skT53_07340	COG1546	Belongs to the CinA family
skT53_07340	COG1058	Belongs to the CinA family
skT53_07350	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
skT53_07360	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
skT53_07410	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
skT53_07510	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
skT53_07550	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
skT53_07570	COG1966	Carbon starvation protein
skT53_07580	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
skT53_07590	COG2022	thiamine diphosphate biosynthetic process
skT53_07610	COG0352	thiamine-phosphate diphosphorylase activity
skT53_07630	COG1832	CoA-binding protein
skT53_07650	COG5002	protein histidine kinase activity
skT53_07660	COG0745	RESPONSE REGULATOR receiver
skT53_07670	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
skT53_07680	COG1333	cytochrome c biogenesis protein
skT53_07690	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
skT53_07700	COG1187	pseudouridine synthase activity
skT53_07710	COG0700	Nucleoside recognition
skT53_07720	COG2715	membrane protein required for spore maturation
skT53_07730	COG1686	Belongs to the peptidase S11 family
skT53_07750	COG0815	Transfers the fatty acyl group on membrane lipoproteins
skT53_07770	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
skT53_07780	COG1116	anion transmembrane transporter activity
skT53_07800	COG3874	Sporulation protein YtfJ
skT53_07830	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
skT53_07840	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
skT53_07850	COG1994	Peptidase M50
skT53_07870	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
skT53_07880	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
skT53_07880	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
skT53_07900	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
skT53_07900	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
skT53_07910	COG1686	Belongs to the peptidase S11 family
skT53_07920	COG0019	diaminopimelate decarboxylase activity
skT53_07930	COG0697	spore germination
skT53_07960	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
skT53_07980	COG1191	sigma factor activity
skT53_07990	COG2172	sigma factor antagonist activity
skT53_08000	COG1366	Belongs to the anti-sigma-factor antagonist family
skT53_08010	COG0446	pyridine nucleotide-disulphide oxidoreductase
skT53_08030	COG1686	Belongs to the peptidase S11 family
skT53_08040	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
skT53_08060	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
skT53_08070	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
skT53_08090	COG4974	Belongs to the 'phage' integrase family
skT53_08120	COG0686	Belongs to the AlaDH PNT family
skT53_08130	COG0735	belongs to the Fur family
skT53_08140	COG1300	Membrane
skT53_08180	COG1379	DNA repair
skT53_08190	COG0494	nUDIX hydrolase
skT53_08210	COG2195	Cleaves the N-terminal amino acid of tripeptides
skT53_08250	COG2195	Cleaves the N-terminal amino acid of tripeptides
skT53_08260	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
skT53_08270	COG0346	lactoylglutathione lyase activity
skT53_08280	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
skT53_08280	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
skT53_08290	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
skT53_08290	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
skT53_08330	COG1131	(ABC) transporter
skT53_08360	COG1595	DNA-templated transcription, initiation
skT53_08390	COG0321	lipoyl(octanoyl) transferase activity
skT53_08400	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
skT53_08490	COG0314	molybdopterin synthase activity
skT53_08500	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
skT53_08510	COG0840	transmembrane signaling receptor activity
skT53_08520	COG0531	amino acid
skT53_08550	COG0697	spore germination
skT53_08580	COG2814	Major facilitator Superfamily
skT53_08590	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
skT53_08670	COG0464	growth
skT53_08680	COG1028	Short-chain dehydrogenase reductase Sdr
skT53_08730	COG0586	Pfam SNARE associated Golgi protein
skT53_08740	COG0726	polysaccharide deacetylase
skT53_08750	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
skT53_08770	COG0672	)-iron permease
skT53_08790	COG1525	nuclease
skT53_08860	COG0598	Magnesium transport protein CorA
skT53_08870	COG0745	RESPONSE REGULATOR receiver
skT53_08880	COG0750	zinc metalloprotease
skT53_08890	COG0497	DNA recombination
skT53_08900	COG1438	arginine binding
skT53_08910	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
skT53_08920	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
skT53_08930	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
skT53_08950	COG2323	membrane
skT53_08970	COG1722	exodeoxyribonuclease VII activity
skT53_08980	COG1570	exodeoxyribonuclease VII activity
skT53_08990	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
skT53_09000	COG0492	ferredoxin-NADP+ reductase activity
skT53_09010	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
skT53_09020	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
skT53_09050	COG1302	Protein conserved in bacteria
skT53_09060	COG0439	Biotin carboxylase
skT53_09070	COG0511	ligase activity, forming carbon-carbon bonds
skT53_09150	COG3854	ATPases associated with a variety of cellular activities
skT53_09180	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
skT53_09190	COG0006	proline dipeptidase activity
skT53_09200	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
skT53_09250	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
skT53_09260	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
skT53_09270	COG0404	The glycine cleavage system catalyzes the degradation of glycine
skT53_09280	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
skT53_09320	COG0083	homoserine kinase activity
skT53_09330	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
skT53_09340	COG4492	Belongs to the UPF0735 family
skT53_09370	COG0427	acetyl-CoA hydrolase
skT53_09390	COG3315	Exhibits S-adenosyl-L-methionine-dependent methyltransferase activity
skT53_09400	COG3279	Response regulator of the LytR AlgR family
skT53_09410	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
skT53_09430	COG2271	Major facilitator Superfamily
skT53_09440	COG0318	PFAM AMP-dependent synthetase and ligase
skT53_09460	COG1028	Short-chain dehydrogenase reductase Sdr
skT53_09530	COG0367	asparagine synthase
skT53_09540	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
skT53_09590	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
skT53_09620	COG2267	carboxylic ester hydrolase activity
skT53_09650	COG2814	Major facilitator Superfamily
skT53_09670	COG1802	Transcriptional regulator
skT53_09680	COG4193	domain, Protein
skT53_09680	COG5263	repeat protein
skT53_09690	COG5001	Diguanylate cyclase
skT53_09690	COG1716	ATPase activity
skT53_09710	COG0189	ligase activity
skT53_09720	COG0024	Methionine aminopeptidase
skT53_09730	COG2814	Major facilitator Superfamily
skT53_09740	COG0701	Predicted permease
skT53_09750	COG1108	ABC-type Mn2 Zn2 transport systems permease components
skT53_09760	COG1121	(ABC) transporter
skT53_09770	COG0803	Belongs to the bacterial solute-binding protein 9 family
skT53_09780	COG0735	belongs to the Fur family
skT53_09800	COG1294	oxidase, subunit
skT53_09850	COG4537	Required for transformation and DNA binding
skT53_09860	COG1459	type II secretion system
skT53_09870	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
skT53_09880	COG0730	response to heat
skT53_09890	COG1310	metal-dependent protease of the Pad1 Jab1 superfamily
skT53_09900	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
skT53_09960	COG1215	transferase activity, transferring glycosyl groups
skT53_09990	COG0745	RESPONSE REGULATOR receiver
skT53_10000	COG5002	protein histidine kinase activity
skT53_10040	COG2031	fatty acid transporter
skT53_10100	COG0211	Belongs to the bacterial ribosomal protein bL27 family
skT53_10120	COG0261	This protein binds to 23S rRNA in the presence of protein L20
skT53_10170	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
skT53_10180	COG1063	alcohol dehydrogenase
skT53_10210	COG0284	orotidine-5'-phosphate decarboxylase activity
skT53_10220	COG0167	dihydroorotate dehydrogenase activity
skT53_10230	COG0543	2 iron, 2 sulfur cluster binding
skT53_10240	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
skT53_10260	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
skT53_10270	COG0540	Belongs to the ATCase OTCase family
skT53_10290	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
skT53_10300	COG0564	pseudouridine synthase activity
skT53_10310	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
skT53_10320	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
skT53_10330	COG5658	integral membrane protein
skT53_10340	COG0640	Transcriptional regulator
skT53_10350	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
skT53_10390	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
skT53_10400	COG3599	regulation of cell shape
skT53_10410	COG2302	S4 RNA-binding domain
skT53_10430	COG1799	cell septum assembly
skT53_10440	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
skT53_10460	COG1873	PFAM PRC-barrel domain
skT53_10470	COG1191	sigma factor activity
skT53_10480	COG1191	sigma factor activity
skT53_10500	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
skT53_10510	COG0849	cell division
skT53_10520	COG3856	small basic protein
skT53_10540	COG3879	Bacterial protein of unknown function (DUF881)
skT53_10550	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
skT53_10560	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
skT53_10570	COG0812	UDP-N-acetylmuramate dehydrogenase activity
skT53_10580	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
skT53_10590	COG0772	Belongs to the SEDS family
skT53_10600	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
skT53_10610	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
skT53_10620	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
skT53_10640	COG0768	penicillin binding
skT53_10650	COG0768	penicillin binding
skT53_10670	COG0275	rRNA processing
skT53_10680	COG2001	Belongs to the MraZ family
skT53_10720	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
skT53_10740	COG0180	Tryptophanyl-tRNA synthetase
skT53_10750	COG0180	Tryptophanyl-tRNA synthetase
skT53_10780	COG0861	Integral membrane protein TerC family
skT53_10790	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
skT53_10880	COG1903	Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A
skT53_10910	COG2096	Adenosyltransferase
skT53_10920	COG0778	Nitroreductase
skT53_10950	COG0511	ligase activity, forming carbon-carbon bonds
skT53_10970	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
skT53_10990	COG2030	dehydratase
skT53_11000	COG0318	PFAM AMP-dependent synthetase and ligase
skT53_11020	COG1960	acyl-CoA dehydrogenase activity
skT53_11030	COG1960	acyl-CoA dehydrogenase activity
skT53_11060	COG1024	Enoyl-CoA hydratase
skT53_11070	COG3829	transcription factor binding
skT53_11070	COG3290	protein histidine kinase activity
skT53_11090	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
skT53_11130	COG0318	PFAM AMP-dependent synthetase and ligase
skT53_11140	COG1804	L-carnitine dehydratase bile acid-inducible protein F
skT53_11150	COG1028	Short-chain dehydrogenase reductase Sdr
skT53_11170	COG2030	dehydratase
skT53_11180	COG1960	acyl-CoA dehydrogenase activity
skT53_11190	COG0318	PFAM AMP-dependent synthetase and ligase
skT53_11210	COG0183	Belongs to the thiolase family
skT53_11230	COG0318	PFAM AMP-dependent synthetase and ligase
skT53_11260	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
skT53_11270	COG1024	Enoyl-CoA hydratase
skT53_11280	COG0511	ligase activity, forming carbon-carbon bonds
skT53_11290	COG0439	Biotin carboxylase
skT53_11300	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
skT53_11310	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
skT53_11320	COG1116	anion transmembrane transporter activity
skT53_11350	COG0066	3-isopropylmalate dehydratase activity
skT53_11360	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
skT53_11380	COG0784	Response regulator, receiver
skT53_11390	COG4191	Histidine kinase
skT53_11400	COG0765	amino acid transport
skT53_11410	COG0765	amino acid transport
skT53_11420	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
skT53_11440	COG1028	Short-chain dehydrogenase reductase Sdr
skT53_11450	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
skT53_11490	COG3383	formate dehydrogenase (NAD+) activity
skT53_11500	COG2116	formate transmembrane transporter activity
skT53_11540	COG1217	gtp-binding protein TYPA
skT53_11550	COG1671	Belongs to the UPF0178 family
skT53_11620	COG0740	serine-type endopeptidase activity
skT53_11690	COG3906	Belongs to the UPF0473 family
skT53_11700	COG0697	spore germination
skT53_11710	COG2081	HI0933 family
skT53_11720	COG0598	Magnesium transport protein CorA
skT53_11730	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
skT53_11750	COG3442	glutamine amidotransferase
skT53_11780	COG1376	ErfK ybiS ycfS ynhG family protein
skT53_11800	COG0512	Glutamine amidotransferase of anthranilate synthase
skT53_11830	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
skT53_11860	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
skT53_11870	COG2384	SAM-dependent methyltransferase
skT53_11880	COG0318	PFAM AMP-dependent synthetase and ligase
skT53_11900	COG1960	acyl-CoA dehydrogenase activity
skT53_11910	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
skT53_11920	COG0358	DNA primase activity
skT53_11930	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
skT53_11930	COG0574	Belongs to the PEP-utilizing enzyme family
skT53_11940	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
skT53_11950	COG0517	IMP dehydrogenase activity
skT53_11970	COG0423	glycine-tRNA ligase activity
skT53_11980	COG1575	Belongs to the MenA family. Type 1 subfamily
skT53_11990	COG1381	Involved in DNA repair and RecF pathway recombination
skT53_12010	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
skT53_12020	COG0295	cytidine deaminase activity
skT53_12030	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
skT53_12040	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
skT53_12050	COG1480	7TM receptor with intracellular HD hydrolase
skT53_12060	COG1702	phosphate starvation-inducible protein PhoH
skT53_12100	COG4864	UPF0365 protein
skT53_12110	COG1030	water channel activity
skT53_12120	COG1610	YqeY-like protein
skT53_12130	COG0828	Belongs to the bacterial ribosomal protein bS21 family
skT53_12160	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
skT53_12170	COG1283	sodium-dependent phosphate transmembrane transporter activity
skT53_12180	COG1540	5-oxoprolinase (ATP-hydrolyzing) activity
skT53_12190	COG1984	allophanate hydrolase subunit 2
skT53_12200	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
skT53_12210	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
skT53_12230	COG0778	Nitroreductase
skT53_12240	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
skT53_12250	COG1385	rRNA (uridine-N3-)-methyltransferase activity
skT53_12270	COG2340	Cysteine-rich secretory protein family
skT53_12280	COG0477	Major facilitator Superfamily
skT53_12310	COG0318	PFAM AMP-dependent synthetase and ligase
skT53_12320	COG1309	transcriptional regulator
skT53_12330	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
skT53_12350	COG4149	molybdate abc transporter
skT53_12360	COG0725	ABC transporter, periplasmic molybdate-binding protein
skT53_12380	COG3608	succinylglutamate desuccinylase aspartoacylase
skT53_12380	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
skT53_12400	COG1335	isochorismatase
skT53_12420	COG1063	alcohol dehydrogenase
skT53_12440	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
skT53_12450	COG0583	DNA-binding transcription factor activity
skT53_12460	COG1641	Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2 ), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor- dependent enzymes
skT53_12480	COG1691	(AIR) carboxylase
skT53_12490	COG1606	tRNA processing
skT53_12500	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
skT53_12510	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
skT53_12550	COG3829	transcription factor binding
skT53_12550	COG3290	protein histidine kinase activity
skT53_12560	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
skT53_12570	COG1250	3-hydroxyacyl-CoA dehydrogenase
skT53_12580	COG1028	Short-chain dehydrogenase reductase Sdr
skT53_12590	COG1454	alcohol dehydrogenase
skT53_12600	COG1012	belongs to the aldehyde dehydrogenase family
skT53_12660	COG1609	Transcriptional regulator
skT53_12700	COG1090	epimerase
skT53_12750	COG0768	penicillin binding
skT53_12760	COG4122	O-methyltransferase activity
skT53_12770	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
skT53_12790	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
skT53_12800	COG4472	Bacterial protein of unknown function (DUF965)
skT53_12810	COG0628	permease
skT53_12870	COG1104	cysteine desulfurase activity
skT53_12880	COG1959	2 iron, 2 sulfur cluster binding
skT53_12920	COG1169	isochorismate synthase
skT53_12930	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
skT53_12940	COG0596	Alpha beta hydrolase
skT53_12950	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
skT53_12960	COG0318	PFAM AMP-dependent synthetase and ligase
skT53_12970	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
skT53_12980	COG1028	Short-chain dehydrogenase reductase Sdr
skT53_12990	COG2610	gluconate transmembrane transporter activity
skT53_13000	COG3290	protein histidine kinase activity
skT53_13000	COG3829	transcription factor binding
skT53_13010	COG4948	Mandelate Racemase Muconate Lactonizing
skT53_13020	COG4106	trans-aconitate 2-methyltransferase activity
skT53_13060	COG0482	sulfurtransferase activity
skT53_13090	COG1529	Aldehyde oxidase and xanthine dehydrogenase
skT53_13100	COG1529	Aldehyde oxidase and xanthine dehydrogenase
skT53_13130	COG0346	lactoylglutathione lyase activity
skT53_13140	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
skT53_13150	COG0124	histidyl-tRNA synthetase
skT53_13170	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
skT53_13180	COG0346	lactoylglutathione lyase activity
skT53_13200	COG0798	PFAM Bile acid sodium symporter
skT53_13210	COG0640	Transcriptional regulator
skT53_13220	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
skT53_13230	COG1104	cysteine desulfurase activity
skT53_13240	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
skT53_13250	COG0157	Belongs to the NadC ModD family
skT53_13260	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
skT53_13270	COG1827	regulation of RNA biosynthetic process
skT53_13290	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
skT53_13370	COG1063	alcohol dehydrogenase
skT53_13390	COG1960	acyl-CoA dehydrogenase activity
skT53_13400	COG0318	PFAM AMP-dependent synthetase and ligase
skT53_13430	COG0635	Involved in the biosynthesis of porphyrin-containing compound
skT53_13450	COG0709	Synthesizes selenophosphate from selenide and ATP
skT53_13470	COG1914	H( )-stimulated, divalent metal cation uptake system
skT53_13510	COG3069	C4-dicarboxylate transmembrane transporter activity
skT53_13560	COG1910	domain protein
skT53_13570	COG0303	'Molybdopterin
skT53_13580	COG0746	molybdenum cofactor guanylyltransferase activity
skT53_13600	COG3301	Polysulphide reductase, NrfD
skT53_13610	COG0437	4 iron, 4 sulfur cluster binding
skT53_13630	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
skT53_13650	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
skT53_13660	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
skT53_13680	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
skT53_13690	COG0457	Tetratricopeptide repeat
skT53_13690	COG0705	Rhomboid family
skT53_13700	COG5002	protein histidine kinase activity
skT53_13710	COG5002	protein histidine kinase activity
skT53_13770	COG2050	protein possibly involved in aromatic compounds catabolism
skT53_13780	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
skT53_13800	COG1802	Transcriptional regulator
skT53_13850	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
skT53_13880	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
skT53_13890	COG3290	protein histidine kinase activity
skT53_13900	COG4565	transcriptional regulatory protein
skT53_13910	COG1301	dicarboxylic acid transport
skT53_13940	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
skT53_13970	COG0564	pseudouridine synthase activity
skT53_13990	COG1216	Glycosyl transferase, family 2
skT53_14010	COG2076	Multidrug Resistance protein
skT53_14020	COG0840	transmembrane signaling receptor activity
skT53_14030	COG0367	asparagine synthase
skT53_14050	COG4974	Belongs to the 'phage' integrase family
skT53_14060	COG3584	3D domain protein
skT53_14070	COG2445	Protein of unknown function DUF86
skT53_14080	COG0352	thiamine-phosphate diphosphorylase activity
skT53_14090	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
skT53_14100	COG0584	glycerophosphoryl diester phosphodiesterase
skT53_14110	COG1725	Transcriptional regulator
skT53_14120	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
skT53_14120	COG0674	pyruvate-flavodoxin oxidoreductase activity
skT53_14130	COG1013	pyruvate-flavodoxin oxidoreductase activity
skT53_14140	COG0494	nUDIX hydrolase
skT53_14150	COG0492	ferredoxin-NADP+ reductase activity
skT53_14160	COG4502	5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C)
skT53_14470	COG1802	Transcriptional regulator
skT53_14470	COG4626	Terminase
skT53_14530	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
skT53_14610	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
skT53_14640	COG3935	DnaD domain protein
skT53_14660	COG0270	DNA (cytosine-5-)-methyltransferase activity
skT53_14750	COG3723	Recombinational DNA repair protein, rece pathway
skT53_14760	COG5377	YqaJ viral recombinase family
skT53_14850	COG3617	BRO family, N-terminal domain
skT53_14920	COG1396	sequence-specific DNA binding
skT53_14940	COG2176	DNA-directed DNA polymerase activity
skT53_15000	COG1963	PFAM Acid phosphatase vanadium-dependent haloperoxidase related
skT53_15010	COG1363	Peptidase, m42
skT53_15030	COG3377	Domain of unknown function (DUF1805)
skT53_15070	COG1078	dGTPase activity
skT53_15100	COG0316	Belongs to the HesB IscA family
skT53_15160	COG3584	3D domain protein
skT53_15160	COG1388	LysM domain
skT53_15170	COG1982	Orn Lys Arg decarboxylase major
skT53_15180	COG1388	LysM domain
skT53_15180	COG0791	NLP P60 protein
skT53_15210	COG0697	spore germination
skT53_15220	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
skT53_15230	COG0612	Peptidase, M16
skT53_15240	COG1393	Belongs to the ArsC family
skT53_15250	COG0783	Belongs to the Dps family
skT53_15270	COG2329	Antibiotic biosynthesis monooxygenase
skT53_15300	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
skT53_15350	COG0235	Class ii aldolase
skT53_15360	COG4359	Dephosphorylates 2-hydroxy-3-keto-5-methylthiopentenyl- 1-phosphate (HK-MTPenyl-1-P) yielding 1,2-dihydroxy-3-keto-5- methylthiopentene (DHK-MTPene)
skT53_15370	COG1850	ribulose-bisphosphate carboxylase activity
skT53_15380	COG0436	Aminotransferase
skT53_15390	COG0772	Belongs to the SEDS family
skT53_15410	COG0772	Belongs to the SEDS family
skT53_15420	COG0426	domain, Protein
skT53_15440	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
skT53_15470	COG0739	heme binding
skT53_15520	COG0720	synthase
skT53_15530	COG0602	queuosine metabolic process
skT53_15540	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
skT53_15560	COG0584	glycerophosphoryl diester phosphodiesterase
skT53_15600	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
skT53_15610	COG0612	Peptidase, M16
skT53_15620	COG0612	Peptidase, M16
skT53_15640	COG0583	DNA-binding transcription factor activity
skT53_15650	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
skT53_15690	COG1703	isobutyryl-CoA mutase activity
skT53_15690	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
skT53_15690	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
skT53_15700	COG1309	transcriptional regulator
skT53_15790	COG1960	acyl-CoA dehydrogenase activity
skT53_15800	COG0183	Belongs to the thiolase family
skT53_15810	COG1024	Enoyl-CoA hydratase
skT53_15810	COG1250	3-hydroxyacyl-CoA dehydrogenase
skT53_15830	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
skT53_15840	COG2078	PFAM AMMECR1 domain protein
skT53_15840	COG3885	ferrous iron binding
skT53_15890	COG0644	oxidoreductase
skT53_15900	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
skT53_15910	COG2086	electron transfer activity
skT53_15920	COG2258	MOSC domain
skT53_15930	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
skT53_16070	COG1192	Involved in chromosome partitioning
skT53_16140	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
skT53_16150	COG0368	Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate
skT53_16160	COG1270	Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group
skT53_16170	COG2087	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate
skT53_16180	COG2038	nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity
skT53_16200	COG0385	Bile acid
skT53_16230	COG0517	IMP dehydrogenase activity
skT53_16240	COG0384	phenazine biosynthesis protein PhzF
skT53_16250	COG2814	Major facilitator Superfamily
skT53_16260	COG0789	Transcriptional regulator
skT53_16280	COG1012	belongs to the aldehyde dehydrogenase family
skT53_16300	COG3830	Belongs to the UPF0237 family
skT53_16310	COG2848	UPF0210 protein
skT53_16320	COG3547	Transposase (IS116 IS110 IS902 family)
skT53_16340	COG4647	ligase activity
skT53_16350	COG0146	N-methylhydantoinase B acetone carboxylase alpha subunit
skT53_16360	COG0145	ligase activity
skT53_16400	COG1024	Enoyl-CoA hydratase
skT53_16600	COG2226	methyltransferase
skT53_16620	COG2603	Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
skT53_16660	COG0537	adenosine 5'-monophosphoramidase activity
skT53_16720	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
skT53_16720	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
skT53_16760	COG1388	LysM domain
skT53_16760	COG4942	peptidase
skT53_16770	COG4948	Mandelate Racemase Muconate Lactonizing
skT53_16790	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
skT53_16800	COG0604	alcohol dehydrogenase
skT53_16810	COG3852	Histidine kinase
skT53_16830	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
skT53_16840	COG0785	Cytochrome C biogenesis protein
skT53_16850	COG0477	Major facilitator Superfamily
skT53_16860	COG0247	lactate metabolic process
skT53_16870	COG0277	FAD linked oxidase domain protein
skT53_16890	COG1917	Cupin 2, conserved barrel domain protein
skT53_16900	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
skT53_16920	COG1126	abc transporter atp-binding protein
skT53_16930	COG0765	amino acid transport
skT53_16940	COG0765	amino acid transport
skT53_16950	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
skT53_16980	COG2186	Transcriptional regulator
skT53_16990	COG1361	Conserved repeat domain
skT53_16990	COG2911	Protein conserved in bacteria
skT53_16990	COG3266	domain, Protein
skT53_17000	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
skT53_17010	COG3118	belongs to the thioredoxin family
skT53_17020	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
skT53_17070	COG0628	permease
skT53_17090	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
skT53_17120	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
skT53_17130	COG2086	electron transfer activity
skT53_17140	COG1309	transcriptional regulator
skT53_17160	COG3002	Belongs to the UPF0753 family
skT53_17170	COG5609	conserved protein (DUF2294)
skT53_17180	COG3328	transposase activity
skT53_17190	COG0288	reversible hydration of carbon dioxide
skT53_17200	COG2738	Putative neutral zinc metallopeptidase
skT53_17210	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
skT53_17220	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
skT53_17250	COG0840	transmembrane signaling receptor activity
skT53_17250	COG3290	protein histidine kinase activity
skT53_17270	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
skT53_17290	COG0477	Major facilitator Superfamily
skT53_17310	COG1388	LysM domain
skT53_17310	COG3858	chitin binding
skT53_17340	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
skT53_17350	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
skT53_17360	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
skT53_17370	COG0277	FAD linked oxidase domain protein
skT53_17430	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
skT53_17440	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
skT53_17470	COG0473	3-isopropylmalate dehydrogenase activity
skT53_17500	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
skT53_17510	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
skT53_17520	COG2086	electron transfer activity
skT53_17530	COG1053	succinate dehydrogenase
skT53_17540	COG0583	DNA-binding transcription factor activity
skT53_17550	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
skT53_17560	COG1242	4 iron, 4 sulfur cluster binding
skT53_17580	COG0657	acetylesterase activity
skT53_17630	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
skT53_17650	COG1122	ATPase activity
skT53_17660	COG1268	BioY protein
skT53_17670	COG0360	Binds together with S18 to 16S ribosomal RNA
skT53_17680	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
skT53_17700	COG0291	Belongs to the bacterial ribosomal protein bL35 family
skT53_17710	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
skT53_17740	COG0583	DNA-binding transcription factor activity
skT53_17760	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
skT53_17770	COG0066	3-isopropylmalate dehydratase activity
skT53_17790	COG1595	DNA-templated transcription, initiation
skT53_17800	COG0824	Thioesterase
skT53_17820	COG0166	Belongs to the GPI family
skT53_17920	COG1331	Highly conserved protein containing a thioredoxin domain
skT53_17930	COG1331	Highly conserved protein containing a thioredoxin domain
skT53_18060	COG1250	3-hydroxyacyl-CoA dehydrogenase
skT53_18070	COG0277	FAD linked oxidase domain protein
skT53_18080	COG0247	lactate metabolic process
skT53_18090	COG0277	FAD linked oxidase domain protein
skT53_18100	COG0477	Major facilitator Superfamily
skT53_18170	COG0531	amino acid
skT53_18190	COG0697	spore germination
skT53_18220	COG1024	Enoyl-CoA hydratase
skT53_18230	COG3829	transcription factor binding
skT53_18230	COG3290	protein histidine kinase activity
skT53_18240	COG0183	Belongs to the thiolase family
skT53_18250	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
skT53_18270	COG1250	3-hydroxyacyl-CoA dehydrogenase
skT53_18280	COG1960	acyl-CoA dehydrogenase activity
skT53_18290	COG0318	PFAM AMP-dependent synthetase and ligase
skT53_18300	COG1960	acyl-CoA dehydrogenase activity
skT53_18310	COG1250	3-hydroxyacyl-CoA dehydrogenase
skT53_18330	COG1960	acyl-CoA dehydrogenase activity
skT53_18340	COG1804	L-carnitine dehydratase bile acid-inducible protein F
skT53_18360	COG0318	PFAM AMP-dependent synthetase and ligase
skT53_18370	COG0477	Major facilitator Superfamily
skT53_18390	COG3583	domain protein
skT53_18390	COG3584	3D domain protein
skT53_18410	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
skT53_18410	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
skT53_18440	COG3858	chitin binding
skT53_18450	COG1098	S1 RNA binding domain
skT53_18470	COG0492	ferredoxin-NADP+ reductase activity
skT53_18490	COG1119	ATPase activity
skT53_18500	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
skT53_18530	COG0398	Pfam SNARE associated Golgi protein
skT53_18550	COG0109	protoheme IX farnesyltransferase activity
skT53_18560	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
skT53_18580	COG0116	Belongs to the methyltransferase superfamily
skT53_18610	COG2259	Doxx family
skT53_18640	COG0646	methionine synthase
skT53_18640	COG1410	methionine synthase
skT53_18660	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
skT53_18670	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
skT53_18690	COG0840	transmembrane signaling receptor activity
skT53_18710	COG1232	Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX
skT53_18730	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
skT53_18740	COG3253	May function as heme-dependent peroxidase
skT53_18750	COG0347	Belongs to the P(II) protein family
skT53_18760	COG0004	ammonium transporteR
skT53_18770	COG0028	Belongs to the TPP enzyme family
skT53_18780	COG2205	protein histidine kinase activity
skT53_18790	COG0745	RESPONSE REGULATOR receiver
skT53_18830	COG1063	alcohol dehydrogenase
skT53_18860	COG0667	Aldo Keto reductase
skT53_18870	COG0656	L-ascorbic acid biosynthetic process
skT53_18880	COG0656	L-ascorbic acid biosynthetic process
skT53_18890	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
skT53_18970	COG1506	peptidase
skT53_18980	COG2738	Putative neutral zinc metallopeptidase
skT53_18990	COG1253	flavin adenine dinucleotide binding
skT53_19000	COG0789	Transcriptional regulator
skT53_19010	COG2124	cytochrome p450
skT53_19070	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
skT53_19080	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
skT53_19100	COG1802	Transcriptional regulator
skT53_19120	COG1801	Protein of unknown function DUF72
skT53_19140	COG0189	ligase activity
skT53_19180	COG0154	amidase activity
skT53_19200	COG0708	Exodeoxyribonuclease III
skT53_19210	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
skT53_19230	COG0557	exoribonuclease II activity
skT53_19240	COG1647	Serine aminopeptidase, S33
skT53_19250	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
skT53_19260	COG0148	phosphopyruvate hydratase activity
skT53_19270	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
skT53_19280	COG0149	triose-phosphate isomerase activity
skT53_19290	COG0126	phosphoglycerate kinase activity
skT53_19320	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
skT53_19340	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
skT53_19350	COG0351	phosphomethylpyrimidine kinase
skT53_19390	COG2719	SpoVR family
skT53_19400	COG2718	Belongs to the UPF0229 family
skT53_19410	COG2766	serine protein kinase
skT53_19470	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
skT53_19500	COG1414	Transcriptional regulator
skT53_19520	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
skT53_19530	COG0538	isocitrate dehydrogenase activity
skT53_19580	COG0438	transferase activity, transferring glycosyl groups
skT53_19590	COG0328	RNA-DNA hybrid ribonuclease activity
skT53_19640	COG0697	spore germination
skT53_19660	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
skT53_19680	COG0737	Belongs to the 5'-nucleotidase family
skT53_19690	COG0318	PFAM AMP-dependent synthetase and ligase
skT53_19720	COG4493	Belongs to the UPF0637 family
skT53_19740	COG3663	DNA glycosylase
skT53_19780	COG0156	8-amino-7-oxononanoate synthase activity
skT53_19790	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
skT53_19800	COG0561	phosphatase activity
skT53_19840	COG1028	Short-chain dehydrogenase reductase Sdr
skT53_19860	COG1408	metallophosphoesterase
skT53_19920	COG0438	transferase activity, transferring glycosyl groups
skT53_19920	COG0297	glycogen (starch) synthase activity
skT53_19930	COG2186	Transcriptional regulator
skT53_19940	COG0670	Belongs to the BI1 family
skT53_19960	COG1194	a g-specific adenine glycosylase
skT53_19980	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
skT53_20050	COG4251	negative regulation of phosphorylation
skT53_20050	COG3706	GGDEF domain
skT53_20050	COG2203	Gaf domain
skT53_20050	COG5001	Diguanylate cyclase
skT53_20100	COG0456	acetyltransferase
skT53_20140	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
skT53_20160	COG0220	tRNA (guanine-N7-)-methyltransferase activity
skT53_20170	COG2199	diguanylate cyclase activity
skT53_20170	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
skT53_20210	COG1164	Oligoendopeptidase f
skT53_20220	COG2346	COG2346, Truncated hemoglobins
skT53_20260	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
skT53_20270	COG2199	diguanylate cyclase activity
skT53_20270	COG2203	Gaf domain
skT53_20320	COG1294	oxidase, subunit
skT53_20330	COG1271	oxidase subunit
skT53_20340	COG0861	Integral membrane protein TerC family
skT53_20360	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
skT53_20420	COG0719	Fe-S assembly protein
skT53_20430	COG0822	iron-sulfur transferase activity
skT53_20440	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
skT53_20450	COG0719	Fe-S assembly protein
skT53_20460	COG0396	ATPase activity
skT53_20470	COG1959	2 iron, 2 sulfur cluster binding
skT53_20530	COG1612	heme a metabolic process
skT53_20540	COG0697	spore germination
skT53_20560	COG2233	PERMEase
skT53_20570	COG1611	Belongs to the LOG family
skT53_20590	COG2271	Major facilitator Superfamily
skT53_20600	COG5278	phosphoserine phosphatase activity
skT53_20600	COG0840	transmembrane signaling receptor activity
skT53_20620	COG5002	protein histidine kinase activity
skT53_20620	COG3850	Histidine kinase
skT53_20640	COG0745	RESPONSE REGULATOR receiver
skT53_20700	COG2814	Major facilitator Superfamily
skT53_20710	COG0477	Major facilitator Superfamily
skT53_20720	COG0071	Belongs to the small heat shock protein (HSP20) family
skT53_20750	COG1343	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
skT53_20760	COG1518	maintenance of DNA repeat elements
skT53_20840	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
skT53_20900	COG5002	protein histidine kinase activity
skT53_20910	COG1597	lipid kinase activity
skT53_20920	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
skT53_20930	COG0154	amidase activity
skT53_20940	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
skT53_20950	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
skT53_20960	COG1028	Short-chain dehydrogenase reductase Sdr
skT53_20970	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
skT53_20990	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
skT53_21010	COG0662	Cupin 2, conserved barrel domain protein
skT53_21010	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
skT53_21020	COG0463	Glycosyl transferase, family 2
skT53_21040	COG1910	domain protein
skT53_21090	COG1012	belongs to the aldehyde dehydrogenase family
skT53_21150	COG0210	DNA helicase
skT53_21170	COG0750	zinc metalloprotease
skT53_21180	COG1646	35 carbon atoms) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P), producing heptaprenylglyceryl phosphate (HepGP). This reaction is an ether-bond-formation step in the biosynthesis of archaea-type G1P-based membrane lipids found in Bacillales
skT53_21190	COG4496	protein, YerC YecD
skT53_21220	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
skT53_21250	COG0018	arginyl-trna synthetase
skT53_21270	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
skT53_21300	COG2271	Major facilitator Superfamily
skT53_21310	COG0405	Gamma-glutamyltransferase
skT53_21320	COG0477	Major facilitator Superfamily
skT53_21330	COG0151	Belongs to the GarS family
skT53_21350	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
skT53_21360	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
skT53_21370	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
skT53_21380	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
skT53_21390	COG0047	phosphoribosylformylglycinamidine synthase activity
skT53_21400	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
skT53_21410	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
skT53_21420	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
skT53_21430	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
skT53_21440	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
skT53_21480	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
skT53_21490	COG2252	PERMEase
skT53_21500	COG0518	GMP synthase (glutamine-hydrolyzing) activity
skT53_21500	COG0519	Catalyzes the synthesis of GMP from XMP
skT53_21510	COG1305	Transglutaminase-like
skT53_21530	COG0714	Associated with various cellular activities
skT53_21590	COG0459	protein refolding
skT53_21610	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
skT53_21620	COG0805	protein transport
skT53_21630	COG1763	Mo-molybdopterin cofactor biosynthetic process
skT53_21640	COG0303	'Molybdopterin
skT53_21670	COG4221	oxidoreductase activity
skT53_21680	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
skT53_21690	COG0488	(ABC) transporter
skT53_21730	COG3852	Histidine kinase
skT53_21740	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
skT53_21750	COG0456	acetyltransferase
skT53_21760	COG1214	PFAM Peptidase M22, glycoprotease
skT53_21770	COG0802	atpase or kinase
skT53_21780	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
skT53_21790	COG2201	protein-glutamate methylesterase activity
skT53_21810	COG5577	PFAM Coat F domain
skT53_21820	COG0840	transmembrane signaling receptor activity
skT53_21830	COG2183	response to ionizing radiation
skT53_21870	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
skT53_21880	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
skT53_21930	COG1607	acyl-coa hydrolase
skT53_21940	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
skT53_21970	COG1620	l-lactate permease
skT53_21980	COG1476	TRANSCRIPTIONal
skT53_22000	COG2337	Toxic component of a toxin-antitoxin (TA) module
skT53_22010	COG0864	Transcriptional regulator
skT53_22020	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
skT53_22030	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
skT53_22040	COG1028	Short-chain dehydrogenase reductase Sdr
skT53_22050	COG5002	protein histidine kinase activity
skT53_22060	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
skT53_22100	COG2223	nitrite transmembrane transporter activity
skT53_22130	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
skT53_22150	COG2323	membrane
skT53_22170	COG1988	membrane-bound metal-dependent
skT53_22180	COG0667	Aldo Keto reductase
skT53_22190	COG0412	Dienelactone hydrolase
skT53_22200	COG4221	oxidoreductase activity
skT53_22210	COG3321	synthase
skT53_22210	COG1028	Short-chain dehydrogenase reductase Sdr
skT53_22210	COG0604	alcohol dehydrogenase
skT53_22230	COG1253	flavin adenine dinucleotide binding
skT53_22240	COG0456	acetyltransferase
skT53_22260	COG1573	uracil-dna glycosylase
skT53_22270	COG1733	regulation of RNA biosynthetic process
skT53_22280	COG2259	Doxx family
skT53_22290	COG1733	regulation of RNA biosynthetic process
skT53_22300	COG2259	Doxx family
skT53_22310	COG1741	Belongs to the pirin family
skT53_22320	COG0655	NAD(P)H dehydrogenase (quinone) activity
skT53_22360	COG1017	nitric oxide dioxygenase activity
skT53_22360	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
skT53_22370	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
skT53_22390	COG1063	alcohol dehydrogenase
skT53_22400	COG5577	PFAM Coat F domain
skT53_22430	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
skT53_22440	COG3162	membrane
skT53_22450	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
skT53_22460	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
skT53_22470	COG3275	phosphorelay sensor kinase activity
skT53_22480	COG3279	Response regulator of the LytR AlgR family
skT53_22510	COG1053	succinate dehydrogenase
skT53_22520	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
skT53_22620	COG1309	transcriptional regulator
skT53_22640	COG0656	L-ascorbic acid biosynthetic process
skT53_22700	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
skT53_22710	COG0745	RESPONSE REGULATOR receiver
skT53_22740	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
skT53_22750	COG2046	Belongs to the sulfate adenylyltransferase family
skT53_22760	COG0730	response to heat
skT53_22770	COG0175	sulfate reduction
skT53_22810	COG0726	polysaccharide deacetylase
skT53_22840	COG0489	protein tyrosine kinase activity
skT53_22850	COG0860	N-Acetylmuramoyl-L-alanine amidase
skT53_22860	COG0697	spore germination
skT53_22890	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
skT53_22920	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
skT53_22930	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
skT53_22940	COG0101	tRNA pseudouridine synthase activity
skT53_22950	COG0203	ribosomal protein L17
skT53_22960	COG0202	RNA polymerase activity
skT53_22970	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
skT53_22980	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
skT53_22990	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
skT53_23000	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
skT53_23010	COG2163	COG2163 Ribosomal protein L14E L6E L27E
skT53_23020	COG0024	Methionine aminopeptidase
skT53_23030	COG0563	adenylate kinase activity
skT53_23040	COG0201	protein transport
skT53_23050	COG0200	Binds to the 23S rRNA
skT53_23060	COG1841	ribosomal large subunit assembly
skT53_23070	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
skT53_23080	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
skT53_23090	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
skT53_23100	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
skT53_23110	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
skT53_23140	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
skT53_23160	COG0255	Belongs to the universal ribosomal protein uL29 family
skT53_23170	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
skT53_23180	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
skT53_23200	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
skT53_23210	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
skT53_23220	COG0089	rRNA binding
skT53_23240	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
skT53_23260	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
skT53_23270	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
skT53_23280	COG0049	tRNA binding
skT53_23290	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
skT53_23300	COG1358	cellular component organization or biogenesis
skT53_23310	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
skT53_23320	COG0085	RNA polymerase activity
skT53_23330	COG2813	Specifically methylates the guanine in position
skT53_23340	COG0222	ribosome binding
skT53_23350	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
skT53_23360	COG0081	regulation of translation
skT53_23370	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
skT53_23380	COG0250	Participates in transcription elongation, termination and antitermination
skT53_23390	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
skT53_23400	COG0267	Belongs to the bacterial ribosomal protein bL33 family
skT53_23420	COG3688	RNA-binding protein containing a PIN domain
skT53_23430	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
skT53_23440	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
skT53_23450	COG0215	cysteine-tRNA ligase activity
skT53_23460	COG1045	serine acetyltransferase
skT53_23470	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
skT53_23480	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
skT53_23480	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
skT53_23490	COG4956	integral membrane protein (PIN domain superfamily)
skT53_23500	COG1183	phosphatidylcholine synthase activity
skT53_23510	COG1623	Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c- di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation
skT53_23520	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
skT53_23530	COG0542	response to heat
skT53_23540	COG3869	Catalyzes the specific phosphorylation of arginine residues in
skT53_23550	COG3880	PFAM UvrB UvrC protein
skT53_23600	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
skT53_23620	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
skT53_23630	COG1396	sequence-specific DNA binding
skT53_23640	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
skT53_23640	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
skT53_23650	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
skT53_23660	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
skT53_23670	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
skT53_23680	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
skT53_23690	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
skT53_23700	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
skT53_23720	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
skT53_23740	COG0037	tRNA processing
skT53_23780	COG2304	oxidoreductase activity
skT53_23790	COG2208	phosphoserine phosphatase activity
skT53_23800	COG2131	deaminase
skT53_23830	COG1098	S1 RNA binding domain
skT53_23870	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
skT53_23890	COG3956	TIGRFAM MazG family protein
skT53_23900	COG2244	polysaccharide biosynthetic process
skT53_23910	COG2002	toxin-antitoxin pair type II binding
skT53_23920	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
skT53_23940	COG0193	aminoacyl-tRNA hydrolase activity
skT53_23960	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
skT53_23970	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
skT53_23980	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
skT53_23990	COG2088	sporulation resulting in formation of a cellular spore
skT53_24000	COG0251	oxidation-reduction process
skT53_24010	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
skT53_24030	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
skT53_24040	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
skT53_24040	COG1181	Belongs to the D-alanine--D-alanine ligase family
skT53_24050	COG4242	Belongs to the peptidase S51 family
skT53_24070	COG4466	Protein conserved in bacteria
skT53_24100	COG0688	phosphatidylethanolamine metabolic process
skT53_24110	COG5002	protein histidine kinase activity
skT53_24130	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
skT53_24150	COG0084	hydrolase, TatD family'
skT53_24170	COG2002	toxin-antitoxin pair type II binding
skT53_24180	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
skT53_24190	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
skT53_24200	COG4467	Involved in initiation control of chromosome replication
skT53_24210	COG1774	PSP1 C-terminal conserved region
skT53_24220	COG0470	DNA polymerase III
skT53_24230	COG1728	Protein conserved in bacteria
skT53_24240	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
skT53_24250	COG1982	Orn Lys Arg decarboxylase major
skT53_24300	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
skT53_24310	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
skT53_24320	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
skT53_24370	COG1396	sequence-specific DNA binding
skT53_24430	COG0311	Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS
skT53_24440	COG0214	Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively
skT53_24450	COG1686	Belongs to the peptidase S11 family
skT53_24460	COG0517	IMP dehydrogenase activity
skT53_24460	COG0516	GMP reductase activity
skT53_24500	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
skT53_24510	COG0187	DNA topoisomerase II activity
skT53_24530	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
skT53_24540	COG2501	S4 domain
skT53_24550	COG0592	DNA-directed DNA polymerase activity
skT53_24560	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
skT53_24570	COG0230	Belongs to the bacterial ribosomal protein bL34 family
skT53_24580	COG0594	ribonuclease P activity
skT53_24600	COG0706	membrane insertase activity
skT53_24610	COG1847	R3H domain protein
skT53_24620	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
skT53_24630	COG0445	tRNA wobble uridine modification
skT53_24640	COG0357	Ribosomal RNA small subunit methyltransferase G
skT53_24660	COG1192	Involved in chromosome partitioning
skT53_24670	COG1475	DNA binding
skT53_24680	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
skT53_24820	COG0668	transmembrane transport
skT53_24830	COG4481	Protein conserved in bacteria
skT53_24860	COG0513	Belongs to the DEAD box helicase family
skT53_24870	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
skT53_24900	COG0012	GTP binding
skT53_24910	COG0629	single-stranded DNA binding
skT53_24920	COG2807	transmembrane transport
skT53_24930	COG1846	Transcriptional regulator
skT53_24950	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
skT53_25010	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
skT53_25040	COG0359	binds to the 23S rRNA
skT53_25050	COG0470	DNA polymerase III
skT53_25050	COG1067	ATP-dependent peptidase activity
skT53_25060	COG0305	Participates in initiation and elongation during chromosome replication
skT53_25070	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
skT53_25110	COG0745	RESPONSE REGULATOR receiver
skT53_25150	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
skT53_25160	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
skT53_25200	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
skT53_25260	COG2814	Major facilitator Superfamily
skT53_25310	COG1136	(ABC) transporter
skT53_25310	COG0577	efflux transmembrane transporter activity
skT53_25320	COG1136	(ABC) transporter
skT53_25320	COG0577	efflux transmembrane transporter activity
skT53_25330	COG0577	efflux transmembrane transporter activity
skT53_25330	COG1136	(ABC) transporter
skT53_25340	COG1278	Cold shock
skT53_25390	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
skT53_25430	COG1131	(ABC) transporter
skT53_25450	COG0477	Major facilitator Superfamily
skT53_25460	COG1028	Short-chain dehydrogenase reductase Sdr
skT53_25490	COG5577	PFAM Coat F domain
skT53_25500	COG0745	RESPONSE REGULATOR receiver
skT53_25530	COG1113	amino acid transport
skT53_25550	COG3654	unkown
skT53_25580	COG1131	(ABC) transporter
skT53_25590	COG1725	Transcriptional regulator
skT53_25610	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
skT53_25620	COG0656	L-ascorbic acid biosynthetic process
skT53_25630	COG1028	Short-chain dehydrogenase reductase Sdr
skT53_25670	COG3290	protein histidine kinase activity
skT53_25670	COG0840	transmembrane signaling receptor activity
skT53_25680	COG0477	Major facilitator Superfamily
skT53_25690	COG1054	Belongs to the UPF0176 family
skT53_25700	COG0070	glutamate synthase
skT53_25700	COG0067	glutamate synthase
skT53_25700	COG0069	glutamate synthase activity
skT53_25710	COG0493	'glutamate synthase
skT53_25730	COG1132	(ABC) transporter
skT53_25740	COG1132	(ABC) transporter
skT53_25760	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
skT53_25770	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
skT53_25780	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
skT53_25790	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
skT53_25820	COG0129	dihydroxy-acid dehydratase activity
skT53_25830	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
skT53_25840	COG0800	Aldolase
skT53_25850	COG1414	Transcriptional regulator
skT53_25870	COG2721	sulfolactate sulfo-lyase activity
skT53_25880	COG2721	sulfolactate sulfo-lyase activity
skT53_25920	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
skT53_25940	COG1414	Transcriptional regulator
skT53_25950	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
skT53_25990	COG5577	PFAM Coat F domain
skT53_26020	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
skT53_26030	COG2224	Isocitrate lyase
skT53_26040	COG4548	von Willebrand factor, type A
skT53_26050	COG0714	Associated with various cellular activities
skT53_26110	COG1139	Iron-sulfur cluster binding protein
skT53_26120	COG1556	Lactate utilization protein
skT53_26130	COG3300	MHYT domain
skT53_26130	COG5001	Diguanylate cyclase
skT53_26140	COG0436	Aminotransferase
skT53_26150	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
skT53_26160	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
skT53_26170	COG0010	Belongs to the arginase family
skT53_26210	COG0183	Belongs to the thiolase family
skT53_26220	COG1250	3-hydroxyacyl-CoA dehydrogenase
skT53_26230	COG1024	Enoyl-CoA hydratase
skT53_26240	COG1960	acyl-CoA dehydrogenase activity
skT53_26260	COG3343	RNA polymerase activity
skT53_26270	COG0504	CTP synthase activity
skT53_26280	COG2204	response regulator
skT53_26300	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
skT53_26310	COG2171	N-acyltransferase activity
skT53_26320	COG1473	amidohydrolase
skT53_26340	COG0436	Aminotransferase
skT53_26360	COG1494	fructose-1,6-bisphosphatase
skT53_26370	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
skT53_26390	COG0725	ABC transporter, periplasmic molybdate-binding protein
skT53_26400	COG0254	rRNA binding
skT53_26420	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
skT53_26430	COG2890	protein-(glutamine-N5) methyltransferase activity
skT53_26440	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
skT53_26470	COG3153	acetyltransferase
skT53_26470	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
skT53_26490	COG0009	L-threonylcarbamoyladenylate synthase
skT53_26520	COG0698	ribose 5-phosphate isomerase
skT53_26530	COG4475	Protein of unknown function (DUF436)
skT53_26540	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
skT53_26580	COG1476	TRANSCRIPTIONal
skT53_26690	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
skT53_26840	COG4948	Mandelate Racemase Muconate Lactonizing
skT53_26900	COG2188	Transcriptional regulator
skT53_26910	COG3180	Ammonia monooxygenase
skT53_26920	COG2186	Transcriptional regulator
skT53_26930	COG0579	oxidoreductase
skT53_26960	COG2814	Major facilitator Superfamily
skT53_26970	COG0277	FAD linked oxidase domain protein
skT53_26980	COG0247	lactate metabolic process
skT53_26990	COG0473	3-isopropylmalate dehydrogenase activity
skT53_27000	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
skT53_27010	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
skT53_27020	COG0183	Belongs to the thiolase family
skT53_27050	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
skT53_27070	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
skT53_27080	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
skT53_27090	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
skT53_27100	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
skT53_27110	COG0355	proton-transporting ATP synthase activity, rotational mechanism
skT53_27130	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
skT53_27140	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
skT53_27150	COG0649	NAD binding
skT53_27160	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
skT53_27170	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
skT53_27200	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
skT53_27210	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
skT53_27220	COG1007	ATP synthesis coupled electron transport
skT53_27250	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
skT53_27260	COG2385	sporulation resulting in formation of a cellular spore
skT53_27280	COG1609	Transcriptional regulator
skT53_27290	COG1077	Cell shape determining protein MreB Mrl
skT53_27300	COG4786	Flagellar basal body rod
skT53_27320	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
skT53_27330	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
skT53_27340	COG1739	Uncharacterized protein family UPF0029
skT53_27350	COG3706	GGDEF domain
skT53_27420	COG0438	transferase activity, transferring glycosyl groups
skT53_27470	COG0463	Glycosyl transferase, family 2
skT53_27540	COG2337	Toxic component of a toxin-antitoxin (TA) module
skT53_27550	COG2336	PFAM SpoVT AbrB
skT53_27560	COG0671	phosphoesterase, PA-phosphatase related
skT53_27570	COG0586	Pfam SNARE associated Golgi protein
skT53_27600	COG0189	ligase activity
skT53_27610	COG5002	protein histidine kinase activity
skT53_27620	COG0745	RESPONSE REGULATOR receiver
skT53_27630	COG3103	Sh3 type 3 domain protein
skT53_27630	COG0791	NLP P60 protein
skT53_27630	COG1388	LysM domain
skT53_27650	COG2814	Major facilitator Superfamily
skT53_27660	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
skT53_27670	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
skT53_27730	COG1216	Glycosyl transferase, family 2
skT53_27730	COG0438	transferase activity, transferring glycosyl groups
skT53_27790	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
skT53_27810	COG1091	dTDP-4-dehydrorhamnose reductase activity
skT53_27860	COG0730	response to heat
skT53_27890	COG0613	PHP domain protein
skT53_27920	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
skT53_27940	COG1846	Transcriptional regulator
skT53_27950	COG1566	PFAM secretion protein HlyD family protein
skT53_27970	COG2814	Major facilitator Superfamily
skT53_28000	COG4846	Membrane protein involved in cytochrome C biogenesis
skT53_28010	COG1566	PFAM secretion protein HlyD family protein
skT53_28020	COG2814	Major facilitator Superfamily
skT53_28040	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
skT53_28070	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
skT53_28130	COG2226	methyltransferase
skT53_28140	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
skT53_28150	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
skT53_28160	COG1210	Utp--glucose-1-phosphate uridylyltransferase
skT53_28190	COG3409	Peptidoglycan-binding domain 1 protein
skT53_28190	COG0793	Belongs to the peptidase S41A family
skT53_28210	COG2244	polysaccharide biosynthetic process
skT53_28240	COG1316	TRANSCRIPTIONal
skT53_28260	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
skT53_28280	COG2197	response regulator
skT53_28310	COG3300	MHYT domain
skT53_28310	COG5001	Diguanylate cyclase
skT53_28340	COG0840	transmembrane signaling receptor activity
skT53_28350	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
skT53_28360	COG0573	inorganic phosphate transmembrane transporter activity
skT53_28370	COG0581	inorganic phosphate transmembrane transporter activity
skT53_28380	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
skT53_28390	COG0704	Plays a role in the regulation of phosphate uptake
skT53_28410	COG0306	phosphate transporter
skT53_28420	COG0745	RESPONSE REGULATOR receiver
skT53_28430	COG5002	protein histidine kinase activity
skT53_28440	COG1307	EDD domain protein, DegV family
skT53_28490	COG4786	Flagellar basal body rod
skT53_28490	COG1256	bacterial-type flagellum assembly
skT53_28500	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
skT53_28530	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
skT53_28540	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
skT53_28560	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
skT53_28610	COG1516	flagellar protein fliS
skT53_28630	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
skT53_28640	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
skT53_28650	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
skT53_28660	COG2089	acid synthase
skT53_28680	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
skT53_28690	COG1083	cytidylyl-transferase
skT53_28710	COG0765	amino acid transport
skT53_28720	COG1126	abc transporter atp-binding protein
skT53_28760	COG0653	protein targeting
skT53_28770	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
skT53_28820	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
skT53_28830	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
skT53_28840	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
skT53_28850	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
skT53_28860	COG0028	Belongs to the TPP enzyme family
skT53_28900	COG0477	Major facilitator Superfamily
skT53_28910	COG0505	Belongs to the CarA family
skT53_28920	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
skT53_28930	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
skT53_28940	COG0137	argininosuccinate synthase activity
skT53_28950	COG0165	Argininosuccinate lyase
skT53_28980	COG2884	Cell division ATP-binding protein ftsE
skT53_28990	COG2177	Part of the ABC transporter FtsEX involved in
skT53_29000	COG0793	Belongs to the peptidase S41A family
skT53_29000	COG3409	Peptidoglycan-binding domain 1 protein
skT53_29010	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
skT53_29030	COG1360	Flagellar Motor Protein
skT53_29040	COG0556	nucleotide-excision repair
skT53_29050	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
skT53_29090	COG2771	luxR family
skT53_29090	COG2200	EAL domain
skT53_29100	COG2201	protein-glutamate methylesterase activity
skT53_29110	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
skT53_29130	COG0739	heme binding
skT53_29130	COG0741	lytic transglycosylase activity
skT53_29130	COG1196	nuclear chromosome segregation
skT53_29140	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
skT53_29150	COG0546	phosphoglycolate phosphatase activity
skT53_29160	COG0110	maltose O-acetyltransferase activity
skT53_29170	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
skT53_29180	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
skT53_29190	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
skT53_29200	COG0131	Imidazoleglycerol-phosphate dehydratase
skT53_29210	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
skT53_29220	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
skT53_29230	COG0107	imidazoleglycerol-phosphate synthase activity
skT53_29240	COG0140	phosphoribosyl-ATP diphosphatase activity
skT53_29240	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
skT53_29250	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
skT53_29260	COG0457	Tetratricopeptide repeat
skT53_29290	COG1051	belongs to the nudix hydrolase family
skT53_29300	COG1660	Displays ATPase and GTPase activities
skT53_29310	COG0391	Required for morphogenesis under gluconeogenic growth conditions
skT53_29320	COG1481	regulation of sporulation
skT53_29330	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
skT53_29360	COG0477	Major facilitator Superfamily
skT53_29370	COG1346	cytolysis
skT53_29390	COG0583	DNA-binding transcription factor activity
skT53_29400	COG0840	transmembrane signaling receptor activity
skT53_29470	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
skT53_29530	COG0583	DNA-binding transcription factor activity
skT53_29540	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
skT53_29550	COG2962	Rard protein
skT53_29570	COG1024	Enoyl-CoA hydratase
skT53_29580	COG0318	PFAM AMP-dependent synthetase and ligase
skT53_29600	COG2271	Major facilitator Superfamily
skT53_29620	COG1309	transcriptional regulator
skT53_29660	COG4032	Thiamine pyrophosphate enzyme, N-terminal TPP binding domain
skT53_29660	COG0028	Belongs to the TPP enzyme family
skT53_29690	COG0726	polysaccharide deacetylase
skT53_29710	COG3639	organic phosphonate transmembrane transporter activity
skT53_29720	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
skT53_29730	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
skT53_29790	COG0583	DNA-binding transcription factor activity
skT53_29800	COG0069	glutamate synthase activity
skT53_29840	COG2059	Chromate
skT53_29850	COG2059	Chromate
skT53_29860	COG5002	protein histidine kinase activity
skT53_29880	COG1360	Flagellar Motor Protein
skT53_29890	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
skT53_29910	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
skT53_29920	COG0604	alcohol dehydrogenase
skT53_29940	COG0183	Belongs to the thiolase family
skT53_30000	COG4109	DRTGG domain
skT53_30010	COG0587	DNA-directed DNA polymerase activity
skT53_30020	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
skT53_30030	COG0281	malic enzyme
skT53_30050	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
skT53_30060	COG0825	malonyl-CoA metabolic process
skT53_30070	COG0205	6-phosphofructokinase activity
skT53_30100	COG3030	protein affecting phage T7 exclusion by the F plasmid
skT53_30110	COG0538	isocitrate dehydrogenase activity
skT53_30120	COG0039	L-malate dehydrogenase activity
skT53_30170	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
skT53_30170	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
skT53_30180	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
skT53_30190	COG1971	Probably functions as a manganese efflux pump
skT53_30200	COG0237	dephospho-CoA kinase activity
skT53_30220	COG3290	protein histidine kinase activity
skT53_30220	COG3829	transcription factor binding
skT53_30270	COG1288	antiporter activity
skT53_30280	COG1288	antiporter activity
skT53_30290	COG0477	Major facilitator Superfamily
skT53_30300	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
skT53_30310	COG1929	Belongs to the glycerate kinase type-1 family
skT53_30360	COG2755	lipolytic protein G-D-S-L family
skT53_30370	COG1131	(ABC) transporter
skT53_30390	COG0768	penicillin binding
skT53_30400	COG0736	holo-[acyl-carrier-protein] synthase activity
skT53_30420	COG0372	Belongs to the citrate synthase family
skT53_30430	COG0860	N-Acetylmuramoyl-L-alanine amidase
skT53_30450	COG0517	IMP dehydrogenase activity
skT53_30480	COG0739	heme binding
skT53_30510	COG0436	Aminotransferase
skT53_30530	COG0861	Integral membrane protein TerC family
skT53_30540	COG1024	Enoyl-CoA hydratase
skT53_30550	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
skT53_30580	COG0778	Nitroreductase
skT53_30640	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
skT53_30650	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
skT53_30660	COG1733	regulation of RNA biosynthetic process
skT53_30670	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
skT53_30690	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
skT53_30710	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
skT53_30750	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
skT53_30760	COG0569	domain protein
skT53_30770	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
skT53_30790	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
skT53_30800	COG0072	phenylalanine-tRNA ligase activity
skT53_30800	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
skT53_30810	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
skT53_30820	COG1286	toxin biosynthetic process
skT53_30840	COG1193	negative regulation of DNA recombination
skT53_30860	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
skT53_30870	COG3852	Histidine kinase
skT53_30930	COG0460	homoserine dehydrogenase
skT53_30940	COG1605	Chorismate mutase
skT53_30940	COG0077	Prephenate dehydratase
skT53_30960	COG0028	Belongs to the TPP enzyme family
skT53_30970	COG0440	acetolactate synthase activity
skT53_30990	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
skT53_31000	COG0473	3-isopropylmalate dehydrogenase activity
skT53_31030	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
skT53_31050	COG0523	cobalamin synthesis protein
skT53_31060	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
skT53_31070	COG0632	four-way junction helicase activity
skT53_31080	COG2255	four-way junction helicase activity
skT53_31100	COG1191	sigma factor activity
skT53_31110	COG4447	cellulose binding
skT53_31120	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
skT53_31130	COG0343	queuine tRNA-ribosyltransferase activity
skT53_31140	COG1862	Preprotein translocase
skT53_31160	COG2323	membrane
skT53_31170	COG2244	polysaccharide biosynthetic process
skT53_31190	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
skT53_31200	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
skT53_31210	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
skT53_31210	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
skT53_31230	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
skT53_31240	COG1490	D-aminoacyl-tRNA deacylase activity
skT53_31250	COG1979	alcohol dehydrogenase
skT53_31300	COG0840	transmembrane signaling receptor activity
skT53_31320	COG1273	With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD
skT53_31360	COG3842	ATPase activity
skT53_31390	COG4464	protein tyrosine phosphatase activity
skT53_31450	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
skT53_31460	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
skT53_31510	COG4962	Type ii secretion system protein e
skT53_31610	COG0659	secondary active sulfate transmembrane transporter activity
skT53_31640	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
skT53_31690	COG3384	dioxygenase
skT53_31700	COG1793	dna ligase
skT53_31720	COG0318	PFAM AMP-dependent synthetase and ligase
skT53_31730	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
skT53_31740	COG1216	Glycosyl transferase, family 2
skT53_31770	COG4549	nuclear export factor GLE1
skT53_31790	COG4585	Histidine kinase
skT53_31790	COG2203	Gaf domain
skT53_31800	COG2197	response regulator
skT53_31830	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
skT53_31850	COG2206	PFAM metal-dependent phosphohydrolase, HD sub domain
skT53_31850	COG2199	diguanylate cyclase activity
skT53_31860	COG3326	Membrane
skT53_31890	COG5609	conserved protein (DUF2294)
skT53_31900	COG0531	amino acid
skT53_31920	COG3103	Sh3 type 3 domain protein
skT53_31920	COG1388	LysM domain
skT53_31920	COG0791	NLP P60 protein
skT53_32020	COG1414	Transcriptional regulator
skT53_32030	COG1526	Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH
skT53_32040	COG3383	formate dehydrogenase (NAD+) activity
skT53_32060	COG1045	serine acetyltransferase
skT53_32080	COG0701	Predicted permease
skT53_32100	COG4638	Rieske (2fe-2S)
skT53_32140	COG0028	Belongs to the TPP enzyme family
skT53_32150	COG1012	belongs to the aldehyde dehydrogenase family
skT53_32190	COG0318	PFAM AMP-dependent synthetase and ligase
skT53_32200	COG4977	sequence-specific DNA binding
skT53_32200	COG1917	Cupin 2, conserved barrel domain protein
skT53_32210	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
skT53_32270	COG1024	Enoyl-CoA hydratase
skT53_32280	COG0477	Major facilitator Superfamily
skT53_32300	COG1012	belongs to the aldehyde dehydrogenase family
skT53_32340	COG0420	3'-5' exonuclease activity
skT53_32360	COG0420	3'-5' exonuclease activity
skT53_32370	COG0419	ATPase involved in DNA repair
skT53_32420	COG1028	Short-chain dehydrogenase reductase Sdr
skT53_32480	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
skT53_32490	COG0647	UMP catabolic process
skT53_32500	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
skT53_32530	COG2204	response regulator
skT53_32540	COG3258	Cytochrome c
skT53_32560	COG0446	pyridine nucleotide-disulphide oxidoreductase
skT53_32590	COG1937	Protein conserved in bacteria
skT53_32630	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
skT53_32640	COG2210	Belongs to the sulfur carrier protein TusA family
skT53_32650	COG0730	response to heat
skT53_32660	COG0425	Belongs to the sulfur carrier protein TusA family
skT53_32670	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
skT53_32670	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
skT53_32680	COG0425	Belongs to the sulfur carrier protein TusA family
skT53_32700	COG1937	Protein conserved in bacteria
skT53_32740	COG3858	chitin binding
skT53_32740	COG1388	LysM domain
skT53_32750	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
skT53_32780	COG5002	protein histidine kinase activity
skT53_32790	COG0785	Cytochrome C biogenesis protein
skT53_32820	COG1633	Catalyzes the formation of the isocyclic ring in chlorophyll biosynthesis. Mediates the cyclase reaction, which results in the formation of divinylprotochlorophyllide (Pchlide) characteristic of all chlorophylls from magnesium-protoporphyrin IX 13-monomethyl ester (MgPMME)
skT53_32840	COG0596	Alpha beta hydrolase
skT53_32840	COG0508	dehydrogenase complex catalyzes the overall conversion of
skT53_32880	COG2814	Major facilitator Superfamily
skT53_32880	COG0477	Major facilitator Superfamily
skT53_32900	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
skT53_32920	COG1388	LysM domain
skT53_32920	COG3858	chitin binding
skT53_32970	COG0492	ferredoxin-NADP+ reductase activity
skT53_32990	COG0586	Pfam SNARE associated Golgi protein
skT53_33030	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
skT53_33040	COG0390	transport system, permease component
skT53_33050	COG1028	Short-chain dehydrogenase reductase Sdr
skT53_33060	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
skT53_33070	COG4120	Belongs to the binding-protein-dependent transport system permease family
skT53_33100	COG5337	Spore coat protein CotH
skT53_33110	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
skT53_33150	COG1902	pentaerythritol trinitrate reductase activity
skT53_33160	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
skT53_33170	COG0840	transmembrane signaling receptor activity
skT53_33200	COG1937	Protein conserved in bacteria
skT53_33210	COG1876	peptidase activity
skT53_33230	COG1842	Phage shock protein A
skT53_33310	COG0586	Pfam SNARE associated Golgi protein
skT53_33320	COG2132	Multicopper oxidase
skT53_33330	COG0745	RESPONSE REGULATOR receiver
skT53_33340	COG5002	protein histidine kinase activity
skT53_33370	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
skT53_33390	COG2132	Multicopper oxidase
skT53_33400	COG0745	RESPONSE REGULATOR receiver
skT53_33410	COG5002	protein histidine kinase activity
skT53_33460	COG1937	Protein conserved in bacteria
skT53_33470	COG2217	Heavy metal translocating P-type atpase
skT53_33480	COG2608	mercury ion transmembrane transporter activity
skT53_33490	COG3103	Sh3 type 3 domain protein
skT53_33490	COG0791	NLP P60 protein
skT53_33490	COG1388	LysM domain
skT53_33500	COG0785	Cytochrome C biogenesis protein
skT53_33510	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
skT53_33540	COG1999	signal sequence binding
skT53_33590	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
skT53_33600	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
skT53_33620	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
skT53_33630	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
skT53_33700	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
skT53_33710	COG0163	prenyltransferase activity
skT53_33820	COG1346	cytolysis
skT53_33830	COG1346	cytolysis
skT53_33880	COG1414	Transcriptional regulator
skT53_33910	COG0789	Transcriptional regulator
skT53_33960	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
skT53_33970	COG0318	PFAM AMP-dependent synthetase and ligase
skT53_33990	COG0242	peptide deformylase activity
skT53_34010	COG0024	Methionine aminopeptidase
skT53_34040	COG1959	2 iron, 2 sulfur cluster binding
skT53_34060	COG0114	fumarate hydratase activity
skT53_34090	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
skT53_34160	COG1132	(ABC) transporter
skT53_34170	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
skT53_34200	COG5002	protein histidine kinase activity
skT53_34210	COG2204	response regulator
skT53_34230	COG0180	Tryptophanyl-tRNA synthetase
skT53_34240	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
skT53_34260	COG1587	Uroporphyrinogen-III synthase
skT53_34260	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
skT53_34270	COG0306	phosphate transporter
skT53_34280	COG0175	sulfate reduction
skT53_34290	COG2046	Belongs to the sulfate adenylyltransferase family
skT53_34300	COG0529	Catalyzes the synthesis of activated sulfate
skT53_34310	COG1104	cysteine desulfurase activity
skT53_34320	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
skT53_34360	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
skT53_34370	COG0598	Magnesium transport protein CorA
skT53_34390	COG3162	membrane
skT53_34400	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
skT53_34410	COG2827	Endonuclease containing a URI domain
skT53_34420	COG0387	Pfam Sodium calcium exchanger
skT53_34430	COG0492	ferredoxin-NADP+ reductase activity
skT53_34440	COG0741	lytic transglycosylase activity
skT53_34480	COG2814	Major facilitator Superfamily
skT53_34490	COG2814	Major facilitator Superfamily
skT53_34510	COG3546	catalase activity
skT53_34540	COG0028	Belongs to the TPP enzyme family
skT53_34550	COG0849	cell division
skT53_34560	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
skT53_34570	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
skT53_34580	COG1605	Chorismate mutase
skT53_34580	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
skT53_34610	COG3773	Cell wall hydrolase
skT53_34660	COG3278	Belongs to the heme-copper respiratory oxidase family
skT53_34670	COG0123	including yeast histone deacetylase and acetoin utilization protein
skT53_34680	COG0517	IMP dehydrogenase activity
skT53_34690	COG0454	-acetyltransferase
skT53_34700	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
skT53_34710	COG5577	PFAM Coat F domain
skT53_34720	COG5577	PFAM Coat F domain
skT53_34760	COG0697	spore germination
skT53_34810	COG0646	methionine synthase
skT53_34810	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
skT53_34830	COG0436	Aminotransferase
skT53_34840	COG1522	sequence-specific DNA binding
skT53_34850	COG0671	phosphoesterase, PA-phosphatase related
skT53_34860	COG0322	excinuclease ABC activity
skT53_34880	COG0527	aspartate kinase activity
skT53_34900	COG1970	mechanosensitive ion channel activity
skT53_34910	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
skT53_34920	COG2009	succinate dehydrogenase
skT53_34930	COG1053	succinate dehydrogenase
skT53_34940	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
skT53_34950	COG2197	response regulator
skT53_34960	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
skT53_34980	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
skT53_34990	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
skT53_35000	COG0544	peptidyl-prolyl cis-trans isomerase activity
skT53_35010	COG0740	serine-type endopeptidase activity
skT53_35020	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
skT53_35030	COG0470	DNA polymerase III
skT53_35030	COG1067	ATP-dependent peptidase activity
skT53_35050	COG0218	Necessary for normal cell division and for the maintenance of normal septation
skT53_35080	COG0697	spore germination
skT53_35090	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
skT53_35100	COG1116	anion transmembrane transporter activity
skT53_35140	COG1294	oxidase, subunit
skT53_35150	COG1271	oxidase subunit
skT53_35170	COG3858	chitin binding
skT53_35170	COG1388	LysM domain
skT53_35190	COG0179	Fumarylacetoacetate (FAA) hydrolase
skT53_35200	COG2186	Transcriptional regulator
skT53_35210	COG1073	alpha beta
skT53_35220	COG1228	amidohydrolase
skT53_35250	COG4191	Histidine kinase
skT53_35270	COG1902	pentaerythritol trinitrate reductase activity
skT53_35280	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
skT53_35290	COG1960	acyl-CoA dehydrogenase activity
skT53_35300	COG1802	Transcriptional regulator
skT53_35310	COG1804	L-carnitine dehydratase bile acid-inducible protein F
skT53_35330	COG2814	Major facilitator Superfamily
skT53_35360	COG1012	belongs to the aldehyde dehydrogenase family
skT53_35370	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
skT53_35380	COG2197	response regulator
skT53_35390	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
skT53_35400	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
skT53_35420	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
skT53_35430	COG1534	Rna-binding protein
skT53_35450	COG1713	HD superfamily hydrolase involved in NAD metabolism
skT53_35460	COG0799	negative regulation of ribosome biogenesis
skT53_35470	COG2226	methyltransferase
skT53_35480	COG1492	cobalamin metabolic process
skT53_35490	COG2096	Adenosyltransferase
skT53_35500	COG3858	chitin binding
skT53_35500	COG1388	LysM domain
skT53_35520	COG0495	leucyl-tRNA aminoacylation
skT53_35580	COG5002	protein histidine kinase activity
skT53_35600	COG1181	Belongs to the D-alanine--D-alanine ligase family
skT53_35610	COG1321	iron dependent repressor
skT53_35620	COG0316	Belongs to the HesB IscA family
skT53_35640	COG0450	alkyl hydroperoxide reductase
skT53_35650	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
skT53_35660	COG1555	photosystem II stabilization
skT53_35660	COG1596	polysaccharide export
skT53_35680	COG0658	competence protein
skT53_35680	COG2333	competence protein COMEC
skT53_35740	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
skT53_35770	COG1252	NADH dehydrogenase
skT53_35780	COG1466	dna polymerase III delta subunit
skT53_35800	COG0268	Binds directly to 16S ribosomal RNA
skT53_35820	COG0860	N-Acetylmuramoyl-L-alanine amidase
skT53_35840	COG0481	GTPase activity
skT53_35870	COG0635	Involved in the biosynthesis of porphyrin-containing compound
skT53_35880	COG1420	regulation of RNA biosynthetic process
skT53_35900	COG0443	Heat shock 70 kDa protein
skT53_35910	COG0484	heat shock protein binding
skT53_35960	COG2801	Transposase and inactivated derivatives