locus-tag	class	description
Ent638_0003	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
Ent638_0004	COG0187	DNA topoisomerase II activity
Ent638_0005	COG0561	phosphatase activity
Ent638_0006	COG2186	Transcriptional regulator
Ent638_0007	COG3734	2-keto-3-deoxy-galactonokinase
Ent638_0008	COG0800	Aldolase
Ent638_0009	COG4948	Mandelate Racemase Muconate Lactonizing
Ent638_0010	COG2271	Major facilitator Superfamily
Ent638_0011	COG0823	Involved in the tonB-independent uptake of proteins
Ent638_0012	COG5645	(Lipo)protein
Ent638_0014	COG0071	Belongs to the small heat shock protein (HSP20) family
Ent638_0015	COG2985	domain, Protein
Ent638_0016	COG2188	Transcriptional regulator
Ent638_0019	COG2149	membrane
Ent638_0023	COG2814	Major facilitator Superfamily
Ent638_0025	COG0028	Belongs to the TPP enzyme family
Ent638_0026	COG0440	acetolactate synthase activity
Ent638_0027	COG2197	response regulator
Ent638_0033	COG0697	spore germination
Ent638_0034	COG4580	involved in the transport of maltose and maltodextrins
Ent638_0035	COG1447	Phosphotransferase system cellobiose-specific component IIA
Ent638_0036	COG2723	6-phospho-beta-galactosidase activity
Ent638_0037	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
Ent638_0039	COG1609	Transcriptional regulator
Ent638_0042	COG1309	transcriptional regulator
Ent638_0045	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
Ent638_0045	COG2169	Transcriptional regulator
Ent638_0046	COG1464	Belongs to the NlpA lipoprotein family
Ent638_0050	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
Ent638_0060	COG2801	Transposase and inactivated derivatives
Ent638_0062	COG3272	Protein of unknown function (DUF1722)
Ent638_0063	COG2351	hydroxyisourate hydrolase activity
Ent638_0064	COG0789	Transcriptional regulator
Ent638_0070	COG2211	Major facilitator Superfamily
Ent638_0071	COG1501	Belongs to the glycosyl hydrolase 31 family
Ent638_0072	COG2982	Protein involved in outer membrane biogenesis
Ent638_0073	COG2233	PERMEase
Ent638_0078	COG3539	Fimbrial protein
Ent638_0084	COG3188	usher protein
Ent638_0085	COG3121	Chaperone
Ent638_0087	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
Ent638_0088	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
Ent638_0089	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
Ent638_0090	COG1758	RNA polymerase activity
Ent638_0092	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
Ent638_0093	COG2194	sulfuric ester hydrolase activity
Ent638_0094	COG2860	membrane
Ent638_0095	COG1561	YicC-like family, N-terminal region
Ent638_0096	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
Ent638_0097	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
Ent638_0098	COG1309	transcriptional regulator
Ent638_0099	COG0756	dUTP diphosphatase activity
Ent638_0100	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
Ent638_0101	COG2003	Belongs to the UPF0758 family
Ent638_0102	COG0227	Belongs to the bacterial ribosomal protein bL28 family
Ent638_0104	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
Ent638_0105	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
Ent638_0107	COG1519	Transferase
Ent638_0110	COG1216	Glycosyl transferase, family 2
Ent638_0113	COG0438	transferase activity, transferring glycosyl groups
Ent638_0114	COG0859	PFAM glycosyl transferase family 9
Ent638_0115	COG0859	PFAM glycosyl transferase family 9
Ent638_0116	COG0859	PFAM glycosyl transferase family 9
Ent638_0117	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Ent638_0119	COG1063	alcohol dehydrogenase
Ent638_0120	COG0463	Glycosyl transferase, family 2
Ent638_0121	COG2861	carbohydrate metabolic process
Ent638_0122	COG4942	peptidase
Ent638_0123	COG0696	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
Ent638_0124	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
Ent638_0125	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
Ent638_0126	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
Ent638_0127	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
Ent638_0129	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
Ent638_0130	COG1304	FMN binding
Ent638_0131	COG2186	Transcriptional regulator
Ent638_0134	COG3722	fumarate hydratase activity
Ent638_0136	COG2213	PTS system mannitol-specific
Ent638_0136	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
Ent638_0138	COG1566	PFAM secretion protein HlyD family protein
Ent638_0139	COG0625	glutathione transferase activity
Ent638_0141	COG3276	selenocysteine insertion sequence binding
Ent638_0142	COG1454	alcohol dehydrogenase
Ent638_0143	COG1012	belongs to the aldehyde dehydrogenase family
Ent638_0144	COG0583	DNA-binding transcription factor activity
Ent638_0145	COG3713	MltA-interacting MipA family protein
Ent638_0146	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
Ent638_0149	COG3977	Valine--pyruvate aminotransferase
Ent638_0150	COG0366	Alpha amylase catalytic
Ent638_0151	COG2992	FlgJ-related protein
Ent638_0152	COG1609	Transcriptional regulator
Ent638_0152	COG2207	Transcriptional regulator
Ent638_0153	COG4214	carbohydrate transport
Ent638_0154	COG1129	ABC transporter
Ent638_0155	COG4213	ABC transporter substrate-binding protein
Ent638_0156	COG2115	Belongs to the xylose isomerase family
Ent638_0157	COG1070	Carbohydrate kinase
Ent638_0158	COG1335	isochorismatase
Ent638_0159	COG2169	Transcriptional regulator
Ent638_0160	COG3274	enterobacterial common antigen metabolic process
Ent638_0162	COG0752	glycyl-tRNA synthetase alpha subunit
Ent638_0163	COG0751	glycine-tRNA ligase activity
Ent638_0164	COG2944	sequence-specific DNA binding
Ent638_0166	COG1278	Cold shock
Ent638_0167	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
Ent638_0169	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
Ent638_0171	COG1609	Transcriptional regulator
Ent638_0172	COG2885	chlorophyll binding
Ent638_0173	COG0243	molybdopterin cofactor binding
Ent638_0174	COG0456	acetyltransferase
Ent638_0175	COG2818	Glycosylase
Ent638_0176	COG5571	outer membrane autotransporter
Ent638_0177	COG2223	nitrite transmembrane transporter activity
Ent638_0178	COG2194	sulfuric ester hydrolase activity
Ent638_0180	COG1134	teichoic acid transport
Ent638_0180	COG1388	LysM domain
Ent638_0184	COG0747	negative chemotaxis
Ent638_0185	COG0601	transmembrane transport
Ent638_0186	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
Ent638_0187	COG0444	Belongs to the ABC transporter superfamily
Ent638_0188	COG4608	Belongs to the ABC transporter superfamily
Ent638_0189	COG1072	(Pantothenic acid kinase))
Ent638_0190	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
Ent638_0191	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
Ent638_0192	COG0250	Participates in transcription elongation, termination and antitermination
Ent638_0193	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
Ent638_0194	COG0081	regulation of translation
Ent638_0195	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
Ent638_0196	COG0222	ribosome binding
Ent638_0197	COG0085	RNA polymerase activity
Ent638_0198	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
Ent638_0201	COG1278	Cold shock
Ent638_0203	COG2022	thiamine diphosphate biosynthetic process
Ent638_0204	COG2104	thiamine diphosphate biosynthetic process
Ent638_0205	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
Ent638_0206	COG0352	thiamine-phosphate diphosphorylase activity
Ent638_0208	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
Ent638_0209	COG2816	NAD+ diphosphatase activity
Ent638_0210	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
Ent638_0211	COG1515	deoxyribonuclease V activity
Ent638_0212	COG3068	Protein conserved in bacteria
Ent638_0213	COG0776	regulation of translation
Ent638_0215	COG0151	Belongs to the GarS family
Ent638_0217	COG1897	L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine
Ent638_0218	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
Ent638_0220	COG4579	[isocitrate dehydrogenase (NADP+)] phosphatase activity
Ent638_0224	COG3636	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
Ent638_0225	COG3657	addiction module killer protein
Ent638_0226	COG1187	pseudouridine synthase activity
Ent638_0229	COG0527	aspartate kinase activity
Ent638_0230	COG0166	Belongs to the GPI family
Ent638_0234	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
Ent638_0235	COG3223	Belongs to the PsiE family
Ent638_0236	COG3833	ABC-type maltose transport systems, permease component
Ent638_0241	COG4580	involved in the transport of maltose and maltodextrins
Ent638_0243	COG3161	chorismate lyase activity
Ent638_0244	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
Ent638_0245	COG2937	Belongs to the GPAT DAPAT family
Ent638_0246	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
Ent638_0247	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
Ent638_0248	COG0534	Mate efflux family protein
Ent638_0249	COG3237	CsbD-like
Ent638_0250	COG0735	belongs to the Fur family
Ent638_0253	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
Ent638_0255	COG0604	alcohol dehydrogenase
Ent638_0256	COG0305	Participates in initiation and elongation during chromosome replication
Ent638_0257	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
Ent638_0258	COG1448	Aminotransferase
Ent638_0259	COG3700	Belongs to the class B bacterial acid phosphatase family
Ent638_0260	COG2315	Protein conserved in bacteria
Ent638_0261	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
Ent638_0262	COG0629	single-stranded DNA binding
Ent638_0265	COG4943	cyclic-guanylate-specific phosphodiesterase activity
Ent638_0267	COG0789	Transcriptional regulator
Ent638_0269	COG2252	PERMEase
Ent638_0270	COG0025	NhaP-type Na H and K H
Ent638_0271	COG0583	DNA-binding transcription factor activity
Ent638_0273	COG1346	cytolysis
Ent638_0274	COG4147	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
Ent638_0275	COG3162	membrane
Ent638_0276	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
Ent638_0277	COG1301	dicarboxylic acid transport
Ent638_0278	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
Ent638_0280	COG1733	regulation of RNA biosynthetic process
Ent638_0281	COG3383	formate dehydrogenase (NAD+) activity
Ent638_0282	COG3383	formate dehydrogenase (NAD+) activity
Ent638_0285	COG0191	fructose-bisphosphate aldolase activity
Ent638_0287	COG1879	ABC-type sugar transport system periplasmic component
Ent638_0288	COG1172	Belongs to the binding-protein-dependent transport system permease family
Ent638_0289	COG1129	ABC transporter
Ent638_0294	COG5499	transcription regulator containing HTH domain
Ent638_0295	COG4680	protein conserved in bacteria
Ent638_0296	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
Ent638_0297	COG0456	acetyltransferase
Ent638_0298	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
Ent638_0299	COG3454	Phosphonate metabolism
Ent638_0300	COG4778	phosphonate C-P lyase system protein PhnL
Ent638_0301	COG4107	phosphonate C-P lyase system protein PhnK
Ent638_0302	COG3627	carbon phosphorus lyase activity
Ent638_0303	COG3626	phosphonate metabolism
Ent638_0304	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
Ent638_0305	COG3624	Phosphonate C-P lyase system protein PhnG
Ent638_0306	COG2188	Transcriptional regulator
Ent638_0307	COG3639	organic phosphonate transmembrane transporter activity
Ent638_0308	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
Ent638_0310	COG2764	glyoxalase bleomycin resistance protein dioxygenase
Ent638_0311	COG2824	Alkylphosphonate utilization operon protein PhnA
Ent638_0312	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
Ent638_0315	COG0477	Major facilitator Superfamily
Ent638_0316	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
Ent638_0322	COG1309	transcriptional regulator
Ent638_0325	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
Ent638_0326	COG1027	Aspartate ammonia-lyase
Ent638_0327	COG3030	protein affecting phage T7 exclusion by the F plasmid
Ent638_0328	COG0531	amino acid
Ent638_0329	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
Ent638_0330	COG0459	protein refolding
Ent638_0332	COG1509	lysine 2,3-aminomutase activity
Ent638_0333	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
Ent638_0340	COG3080	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
Ent638_0341	COG3029	Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane
Ent638_0342	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
Ent638_0343	COG1053	succinate dehydrogenase
Ent638_0344	COG2269	With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P
Ent638_0345	COG1511	domain protein
Ent638_0345	COG3264	Mechanosensitive ion channel
Ent638_0348	COG1949	3'-to-5' exoribonuclease specific for small oligoribonucleotides
Ent638_0350	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
Ent638_0350	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
Ent638_0351	COG0802	atpase or kinase
Ent638_0353	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
Ent638_0354	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
Ent638_0355	COG1923	regulation of RNA biosynthetic process
Ent638_0356	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
Ent638_0357	COG0330	HflC and HflK could
Ent638_0358	COG0330	HflC and HflK could
Ent638_0359	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
Ent638_0360	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
Ent638_0361	COG1959	2 iron, 2 sulfur cluster binding
Ent638_0362	COG0557	exoribonuclease II activity
Ent638_0363	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
Ent638_0364	COG0477	Major facilitator Superfamily
Ent638_0365	COG1960	acyl-CoA dehydrogenase activity
Ent638_0366	COG0840	transmembrane signaling receptor activity
Ent638_0368	COG3650	response to hydrogen peroxide
Ent638_0369	COG1073	alpha beta
Ent638_0371	COG0360	Binds together with S18 to 16S ribosomal RNA
Ent638_0372	COG2965	DNA replication, synthesis of RNA primer
Ent638_0374	COG0359	binds to the 23S rRNA
Ent638_0376	COG3061	Opacity-associated protein A
Ent638_0377	COG0545	Peptidyl-prolyl cis-trans isomerase
Ent638_0378	COG1113	amino acid transport
Ent638_0379	COG2846	Di-iron-containing protein involved in the repair of iron-sulfur clusters
Ent638_0380	COG0840	transmembrane signaling receptor activity
Ent638_0381	COG0697	spore germination
Ent638_0383	COG0702	epimerase
Ent638_0384	COG1733	regulation of RNA biosynthetic process
Ent638_0387	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
Ent638_0390	COG4319	ketosteroid isomerase
Ent638_0393	COG1218	3'(2'),5'-bisphosphate nucleotidase
Ent638_0394	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
Ent638_0396	COG1253	flavin adenine dinucleotide binding
Ent638_0397	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
Ent638_0398	COG0729	surface antigen
Ent638_0399	COG2911	Protein conserved in bacteria
Ent638_0400	COG2105	PFAM AIG2 family protein
Ent638_0403	COG3188	usher protein
Ent638_0404	COG3121	Chaperone
Ent638_0407	COG3539	Fimbrial protein
Ent638_0408	COG3539	Fimbrial protein
Ent638_0411	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
Ent638_0412	COG1879	ABC-type sugar transport system periplasmic component
Ent638_0413	COG1129	ABC transporter
Ent638_0414	COG1172	Belongs to the binding-protein-dependent transport system permease family
Ent638_0415	COG1172	Belongs to the binding-protein-dependent transport system permease family
Ent638_0417	COG0583	DNA-binding transcription factor activity
Ent638_0418	COG0158	D-fructose-1,6-bisphosphate 1-phosphohydrolase class 1
Ent638_0419	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
Ent638_0421	COG3028	Belongs to the UPF0307 family
Ent638_0422	COG0312	modulator of DNA gyrase
Ent638_0423	COG3783	Cytochrome b(562)
Ent638_0429	COG3964	amidohydrolase
Ent638_0433	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
Ent638_0433	COG3711	transcriptional antiterminator
Ent638_0434	COG3077	Addiction module antitoxin, RelB DinJ family
Ent638_0435	COG2026	Addiction module toxin, RelE StbE family
Ent638_0436	COG0602	queuosine metabolic process
Ent638_0438	COG0366	Alpha amylase catalytic
Ent638_0439	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
Ent638_0439	COG1263	PTS System
Ent638_0440	COG1609	Transcriptional regulator
Ent638_0442	COG3525	Glycosyl hydrolase, family 20, catalytic domain
Ent638_0445	COG0251	oxidation-reduction process
Ent638_0446	COG1781	'de novo' pyrimidine nucleobase biosynthetic process
Ent638_0447	COG0540	Belongs to the ATCase OTCase family
Ent638_0449	COG1288	antiporter activity
Ent638_0452	COG2235	arginine
Ent638_0453	COG2731	YhcH YjgK YiaL family protein
Ent638_0454	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
Ent638_0455	COG0129	dihydroxy-acid dehydratase activity
Ent638_0456	COG2211	Major facilitator Superfamily
Ent638_0457	COG3507	Belongs to the glycosyl hydrolase 43 family
Ent638_0458	COG1414	Transcriptional regulator
Ent638_0459	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
Ent638_0460	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
Ent638_0463	COG0582	viral genome integration into host DNA
Ent638_0474	COG2003	Belongs to the UPF0758 family
Ent638_0483	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
Ent638_0486	COG0456	acetyltransferase
Ent638_0487	COG0346	lactoylglutathione lyase activity
Ent638_0488	COG1349	DNA-binding transcription factor activity
Ent638_0489	COG0740	serine-type endopeptidase activity
Ent638_0491	COG2850	peptidyl-arginine hydroxylation
Ent638_0494	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
Ent638_0498	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
Ent638_0500	COG0640	Transcriptional regulator
Ent638_0505	COG1566	PFAM secretion protein HlyD family protein
Ent638_0507	COG2733	membrane
Ent638_0508	COG1012	belongs to the aldehyde dehydrogenase family
Ent638_0509	COG0523	cobalamin synthesis protein
Ent638_0510	COG2879	small protein
Ent638_0511	COG1966	Carbon starvation protein
Ent638_0513	COG0840	transmembrane signaling receptor activity
Ent638_0516	COG1484	DNA-dependent DNA replication
Ent638_0518	COG1764	response to oxidative stress
Ent638_0519	COG1846	Transcriptional regulator
Ent638_0520	COG1309	transcriptional regulator
Ent638_0521	COG3610	response to peptide
Ent638_0522	COG2966	Psort location CytoplasmicMembrane, score
Ent638_0523	COG2197	response regulator
Ent638_0524	COG2197	response regulator
Ent638_0525	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
Ent638_0526	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
Ent638_0527	COG4114	ferric iron reductase
Ent638_0528	COG3706	GGDEF domain
Ent638_0530	COG2813	Specifically methylates the guanine in position
Ent638_0531	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
Ent638_0532	COG0456	acetyltransferase
Ent638_0533	COG1011	Hydrolase
Ent638_0534	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
Ent638_0535	COG2823	Periplasmic or secreted lipoprotein
Ent638_0536	COG5487	UPF0391 membrane protein
Ent638_0537	COG4667	esterase of the alpha-beta hydrolase superfamily
Ent638_0538	COG0084	hydrolase, TatD family'
Ent638_0539	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
Ent638_0540	COG1328	CTP reductase activity
Ent638_0541	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
Ent638_0542	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
Ent638_0543	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
Ent638_0544	COG0813	purine-nucleoside phosphorylase activity
Ent638_0545	COG0095	Lipoate-protein ligase
Ent638_0547	COG0560	Phosphoserine phosphatase
Ent638_0550	COG0604	alcohol dehydrogenase
Ent638_0552	COG0488	(ABC) transporter
Ent638_0553	COG0741	lytic transglycosylase activity
Ent638_0554	COG2973	This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regulatory region
Ent638_0555	COG1986	Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions
Ent638_0556	COG0406	alpha-ribazole phosphatase activity
Ent638_0557	COG2207	Transcriptional regulator
Ent638_0557	COG3708	Transcriptional regulator
Ent638_0558	COG3045	CreA protein
Ent638_0559	COG0745	RESPONSE REGULATOR receiver
Ent638_0560	COG2205	protein histidine kinase activity
Ent638_0561	COG4452	Inner membrane protein CreD
Ent638_0562	COG0745	RESPONSE REGULATOR receiver
Ent638_0563	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
Ent638_0564	COG0460	homoserine dehydrogenase
Ent638_0564	COG0527	aspartate kinase activity
Ent638_0566	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
Ent638_0568	COG3022	response to hydroperoxide
Ent638_0569	COG1115	amino acid carrier protein
Ent638_0570	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
Ent638_0571	COG0521	Mo-molybdopterin cofactor biosynthetic process
Ent638_0574	COG1120	ATPase activity
Ent638_0575	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Ent638_0577	COG1584	GPR1 FUN34 yaaH family protein
Ent638_0578	COG0443	Heat shock 70 kDa protein
Ent638_0579	COG0484	heat shock protein binding
Ent638_0580	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
Ent638_0581	COG0583	DNA-binding transcription factor activity
Ent638_0582	COG0268	Binds directly to 16S ribosomal RNA
Ent638_0583	COG0196	riboflavin kinase activity
Ent638_0585	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
Ent638_0586	COG1047	Peptidyl-prolyl cis-trans
Ent638_0587	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
Ent638_0590	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
Ent638_0591	COG0505	Belongs to the CarA family
Ent638_0595	COG2249	NAD(P)H dehydrogenase (quinone) activity
Ent638_0596	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
Ent638_0596	COG0475	glutathione-regulated potassium exporter activity
Ent638_0598	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
Ent638_0599	COG2967	ApaG domain
Ent638_0600	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
Ent638_0601	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
Ent638_0602	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
Ent638_0603	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
Ent638_0605	COG0564	pseudouridine synthase activity
Ent638_0606	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
Ent638_0607	COG0417	DNA replication proofreading
Ent638_0608	COG0235	Class ii aldolase
Ent638_0609	COG2160	L-arabinose isomerase activity
Ent638_0610	COG1069	ribulokinase activity
Ent638_0612	COG0586	Pfam SNARE associated Golgi protein
Ent638_0614	COG1178	ABC-type Fe3 transport system permease component
Ent638_0615	COG4143	(ABC) transporter
Ent638_0618	COG2814	Major facilitator Superfamily
Ent638_0619	COG0066	3-isopropylmalate dehydratase activity
Ent638_0620	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
Ent638_0622	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Ent638_0624	COG0028	Belongs to the TPP enzyme family
Ent638_0625	COG0440	acetolactate synthase activity
Ent638_0626	COG1609	Transcriptional regulator
Ent638_0627	COG2001	Belongs to the MraZ family
Ent638_0628	COG0275	rRNA processing
Ent638_0630	COG0768	penicillin binding
Ent638_0631	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
Ent638_0632	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
Ent638_0633	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
Ent638_0635	COG0772	Belongs to the SEDS family
Ent638_0637	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
Ent638_0638	COG1181	Belongs to the D-alanine--D-alanine ligase family
Ent638_0640	COG0849	cell division
Ent638_0641	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
Ent638_0642	COG0774	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
Ent638_0644	COG0653	protein targeting
Ent638_0645	COG0494	nUDIX hydrolase
Ent638_0646	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
Ent638_0647	COG4582	Cell division factor that enhances FtsZ-ring assembly. Directly interacts with FtsZ and promotes bundling of FtsZ protofilaments, with a reduction in FtsZ GTPase activity
Ent638_0649	COG0516	GMP reductase activity
Ent638_0650	COG1459	type II secretion system
Ent638_0651	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
Ent638_0652	COG4969	Belongs to the N-Me-Phe pilin family
Ent638_0654	COG3023	N-Acetylmuramoyl-L-alanine amidase
Ent638_0655	COG3725	Membrane protein required for beta-lactamase induction
Ent638_0656	COG3940	Belongs to the glycosyl hydrolase 43 family
Ent638_0657	COG2211	Major facilitator Superfamily
Ent638_0658	COG1113	amino acid transport
Ent638_0659	COG2186	Transcriptional regulator
Ent638_0660	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
Ent638_0661	COG0508	dehydrogenase complex catalyzes the overall conversion of
Ent638_0662	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
Ent638_0664	COG3064	Membrane
Ent638_0665	COG1049	propionate catabolic process, 2-methylcitrate cycle
Ent638_0667	COG3112	Uncharacterised protein family (UPF0231)
Ent638_0668	COG1586	Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine
Ent638_0669	COG0421	Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy- AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine
Ent638_0672	COG4993	Dehydrogenase
Ent638_0673	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
Ent638_0674	COG0288	reversible hydration of carbon dioxide
Ent638_0675	COG1131	(ABC) transporter
Ent638_0676	COG0842	Transport permease protein
Ent638_0677	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
Ent638_0678	COG0726	polysaccharide deacetylase
Ent638_0679	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
Ent638_0680	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
Ent638_0681	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
Ent638_0682	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
Ent638_0683	COG0617	tRNA 3'-terminal CCA addition
Ent638_0685	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
Ent638_0686	COG1489	DNA binding
Ent638_0687	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
Ent638_0688	COG1643	Atp-dependent helicase
Ent638_0689	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
Ent638_0690	COG4774	siderophore transport
Ent638_0691	COG1120	ATPase activity
Ent638_0692	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
Ent638_0693	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Ent638_0694	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
Ent638_0696	COG0316	Belongs to the HesB IscA family
Ent638_0697	COG2860	membrane
Ent638_0699	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
Ent638_0700	COG0232	Belongs to the dGTPase family. Type 2 subfamily
Ent638_0702	COG3835	regulator
Ent638_0704	COG2171	N-acyltransferase activity
Ent638_0706	COG0024	Methionine aminopeptidase
Ent638_0707	COG0052	Belongs to the universal ribosomal protein uS2 family
Ent638_0708	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
Ent638_0709	COG0528	UMP kinase activity
Ent638_0710	COG0233	cytoplasmic translational termination
Ent638_0711	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
Ent638_0713	COG0575	Belongs to the CDS family
Ent638_0715	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
Ent638_0717	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
Ent638_0718	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
Ent638_0719	COG1043	involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
Ent638_0720	COG0763	Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
Ent638_0721	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
Ent638_0722	COG0587	DNA-directed DNA polymerase activity
Ent638_0723	COG0825	malonyl-CoA metabolic process
Ent638_0725	COG0346	lactoylglutathione lyase activity
Ent638_0726	COG0037	tRNA processing
Ent638_0727	COG4568	rho-dependent transcription termination
Ent638_0729	COG4681	YaeQ
Ent638_0730	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
Ent638_0731	COG3015	lipoprotein NlpE involved in copper resistance
Ent638_0732	COG0442	prolyl-tRNA aminoacylation
Ent638_0733	COG1720	tRNA m6t6A37 methyltransferase activity
Ent638_0735	COG1464	Belongs to the NlpA lipoprotein family
Ent638_0736	COG2011	ABC-type metal ion transport system permease component
Ent638_0739	COG2963	transposase activity
Ent638_0741	COG2801	Transposase and inactivated derivatives
Ent638_0742	COG0583	DNA-binding transcription factor activity
Ent638_0743	COG3021	interspecies interaction between organisms
Ent638_0744	COG2226	methyltransferase
Ent638_0745	COG0741	lytic transglycosylase activity
Ent638_0745	COG1388	LysM domain
Ent638_0746	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Ent638_0747	COG2226	methyltransferase
Ent638_0748	COG0328	RNA-DNA hybrid ribonuclease activity
Ent638_0749	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
Ent638_0751	COG0444	Belongs to the ABC transporter superfamily
Ent638_0752	COG4608	Belongs to the ABC transporter superfamily
Ent638_0757	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
Ent638_0758	COG1960	acyl-CoA dehydrogenase activity
Ent638_0759	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
Ent638_0760	COG0121	glutamine amidotransferase
Ent638_0761	COG3034	peptidoglycan biosynthetic process
Ent638_0762	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
Ent638_0763	COG2195	Cleaves the N-terminal amino acid of tripeptides
Ent638_0764	COG2236	Acts on guanine, xanthine and to a lesser extent hypoxanthine
Ent638_0767	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
Ent638_0768	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
Ent638_0769	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
Ent638_0770	COG0582	viral genome integration into host DNA
Ent638_0773	COG4725	Belongs to the MT-A70-like family
Ent638_0776	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
Ent638_0785	COG0305	Participates in initiation and elongation during chromosome replication
Ent638_0790	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
Ent638_0821	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
Ent638_0823	COG3104	oligopeptide transport
Ent638_0826	COG0628	permease
Ent638_0827	COG0833	amino acid
Ent638_0828	COG2040	homocysteine
Ent638_0831	COG3842	ATPase activity
Ent638_0833	COG1840	ABC-type Fe3 transport system, periplasmic component
Ent638_0834	COG2271	Major facilitator Superfamily
Ent638_0838	COG4521	taurine ABC transporter
Ent638_0839	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
Ent638_0840	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
Ent638_0841	COG2175	clavaminate synthase activity
Ent638_0843	COG0113	porphobilinogen synthase activity
Ent638_0844	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
Ent638_0846	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
Ent638_0850	COG1181	Belongs to the D-alanine--D-alanine ligase family
Ent638_0854	COG1785	Belongs to the alkaline phosphatase family
Ent638_0856	COG3706	GGDEF domain
Ent638_0857	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
Ent638_0858	COG1671	Belongs to the UPF0178 family
Ent638_0859	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
Ent638_0861	COG4126	flavin adenine dinucleotide binding
Ent638_0862	COG3123	guanosine phosphorylase activity
Ent638_0863	COG2974	May be involved in recombination
Ent638_0864	COG1940	carbohydrate kinase activity
Ent638_0865	COG0419	ATPase involved in DNA repair
Ent638_0866	COG0420	3'-5' exonuclease activity
Ent638_0868	COG5002	protein histidine kinase activity
Ent638_0869	COG1114	Component of the transport system for branched-chain amino acids
Ent638_0871	COG0366	Alpha amylase catalytic
Ent638_0872	COG0450	alkyl hydroperoxide reductase
Ent638_0873	COG3124	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
Ent638_0874	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
Ent638_0875	COG0343	queuine tRNA-ribosyltransferase activity
Ent638_0876	COG1862	Preprotein translocase
Ent638_0877	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
Ent638_0878	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
Ent638_0879	COG3248	Nucleoside-binding outer membrane protein
Ent638_0880	COG4238	major outer membrane lipoprotein
Ent638_0881	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
Ent638_0882	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
Ent638_0882	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
Ent638_0883	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
Ent638_0884	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
Ent638_0885	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
Ent638_0886	COG0667	Aldo Keto reductase
Ent638_0887	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
Ent638_0888	COG0142	geranyltranstransferase activity
Ent638_0889	COG1722	exodeoxyribonuclease VII activity
Ent638_0892	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
Ent638_0893	COG1666	GTP binding
Ent638_0894	COG2814	Major facilitator Superfamily
Ent638_0895	COG0109	protoheme IX farnesyltransferase activity
Ent638_0896	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
Ent638_0897	COG1845	cytochrome c oxidase, subunit III
Ent638_0898	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
Ent638_0899	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
Ent638_0900	COG2223	nitrite transmembrane transporter activity
Ent638_0901	COG3056	Lipoprotein
Ent638_0902	COG0271	Belongs to the BolA IbaG family
Ent638_0903	COG0544	peptidyl-prolyl cis-trans isomerase activity
Ent638_0905	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
Ent638_0906	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
Ent638_0907	COG0776	regulation of translation
Ent638_0908	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
Ent638_0909	COG1555	photosystem II stabilization
Ent638_0910	COG0824	Thioesterase
Ent638_0911	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
Ent638_0912	COG4533	DNA binding
Ent638_0913	COG0561	phosphatase activity
Ent638_0915	COG1522	sequence-specific DNA binding
Ent638_0916	COG1132	(ABC) transporter
Ent638_0917	COG1132	(ABC) transporter
Ent638_0918	COG0347	Belongs to the P(II) protein family
Ent638_0919	COG0004	ammonium transporteR
Ent638_0920	COG1946	Acyl-CoA thioesterase
Ent638_0921	COG3126	Type III secretion system lipoprotein chaperone (YscW)
Ent638_0922	COG3695	enzyme binding
Ent638_0925	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
Ent638_0926	COG2364	Membrane
Ent638_0927	COG1609	Transcriptional regulator
Ent638_0928	COG3250	beta-galactosidase activity
Ent638_0929	COG5507	3-demethylubiquinone-9 3-methyltransferase
Ent638_0930	COG4943	cyclic-guanylate-specific phosphodiesterase activity
Ent638_0932	COG4948	Mandelate Racemase Muconate Lactonizing
Ent638_0933	COG1263	PTS System
Ent638_0933	COG2190	(PTS) system
Ent638_0933	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
Ent638_0935	COG0257	Belongs to the bacterial ribosomal protein bL36 family
Ent638_0939	COG0110	maltose O-acetyltransferase activity
Ent638_0942	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
Ent638_0943	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Ent638_0944	COG1309	transcriptional regulator
Ent638_0945	COG3264	Mechanosensitive ion channel
Ent638_0945	COG1196	nuclear chromosome segregation
Ent638_0947	COG3923	Primosomal replication protein n
Ent638_0948	COG2832	Protein of unknown function (DUF454)
Ent638_0949	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
Ent638_0951	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
Ent638_0952	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
Ent638_0953	COG0326	Molecular chaperone. Has ATPase activity
Ent638_0954	COG0563	adenylate kinase activity
Ent638_0955	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
Ent638_0956	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
Ent638_0957	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
Ent638_0957	COG4651	solute:proton antiporter activity
Ent638_0958	COG2223	nitrite transmembrane transporter activity
Ent638_0959	COG0737	Belongs to the 5'-nucleotidase family
Ent638_0960	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
Ent638_0961	COG3735	TraB family
Ent638_0964	COG1585	Membrane protein implicated in regulation of membrane protease activity
Ent638_0965	COG0330	HflC and HflK could
Ent638_0966	COG3118	belongs to the thioredoxin family
Ent638_0967	COG0300	oxidoreductase activity
Ent638_0968	COG2755	lipolytic protein G-D-S-L family
Ent638_0969	COG4181	ATPase activity
Ent638_0970	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
Ent638_0971	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
Ent638_0972	COG1464	Belongs to the NlpA lipoprotein family
Ent638_0976	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
Ent638_0977	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
Ent638_0978	COG2908	Hydrolyzes the pyrophosphate bond of UDP-2,3- diacylglucosamine to yield 2,3-diacylglucosamine 1-phosphate (lipid X) and UMP by catalyzing the attack of water at the alpha-P atom. Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
Ent638_0979	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
Ent638_0980	COG0215	cysteine-tRNA ligase activity
Ent638_0982	COG0545	Peptidyl-prolyl cis-trans isomerase
Ent638_0983	COG1609	Transcriptional regulator
Ent638_0984	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
Ent638_0984	COG1263	PTS System
Ent638_0984	COG2190	(PTS) system
Ent638_0985	COG2501	S4 domain
Ent638_0986	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
Ent638_0996	COG0582	viral genome integration into host DNA
Ent638_1059	COG1113	amino acid transport
Ent638_1060	COG2211	Major facilitator Superfamily
Ent638_1062	COG0673	inositol 2-dehydrogenase activity
Ent638_1063	COG1609	Transcriptional regulator
Ent638_1064	COG0668	transmembrane transport
Ent638_1071	COG3188	usher protein
Ent638_1074	COG0778	Nitroreductase
Ent638_1075	COG2315	Protein conserved in bacteria
Ent638_1078	COG2207	Transcriptional regulator
Ent638_1079	COG4774	siderophore transport
Ent638_1082	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
Ent638_1085	COG2170	ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity
Ent638_1087	COG0477	Major facilitator Superfamily
Ent638_1089	COG2200	EAL domain
Ent638_1091	COG0477	Major facilitator Superfamily
Ent638_1094	COG0583	DNA-binding transcription factor activity
Ent638_1095	COG3122	Protein conserved in bacteria
Ent638_1096	COG0564	pseudouridine synthase activity
Ent638_1097	COG1278	Cold shock
Ent638_1099	COG4771	TonB-dependent receptor
Ent638_1100	COG3391	amine dehydrogenase activity
Ent638_1101	COG4608	Belongs to the ABC transporter superfamily
Ent638_1102	COG0444	Belongs to the ABC transporter superfamily
Ent638_1104	COG0601	transmembrane transport
Ent638_1112	COG1121	(ABC) transporter
Ent638_1113	COG1108	ABC-type Mn2 Zn2 transport systems permease components
Ent638_1114	COG1108	ABC-type Mn2 Zn2 transport systems permease components
Ent638_1115	COG2977	Belongs to the P-Pant transferase superfamily
Ent638_1116	COG4771	TonB-dependent receptor
Ent638_1117	COG2382	esterase
Ent638_1118	COG3251	PFAM MbtH domain protein
Ent638_1119	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
Ent638_1119	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
Ent638_1120	COG1120	ATPase activity
Ent638_1121	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Ent638_1122	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Ent638_1123	COG0477	Major facilitator Superfamily
Ent638_1124	COG4592	Periplasmic binding protein
Ent638_1125	COG1169	isochorismate synthase
Ent638_1126	COG1021	2,3-dihydroxybenzoate-AMP ligase
Ent638_1127	COG1535	isochorismatase
Ent638_1127	COG3433	isochorismatase activity
Ent638_1128	COG1028	Short-chain dehydrogenase reductase Sdr
Ent638_1129	COG2050	protein possibly involved in aromatic compounds catabolism
Ent638_1130	COG1966	Carbon starvation protein
Ent638_1131	COG2879	small protein
Ent638_1133	COG1028	Short-chain dehydrogenase reductase Sdr
Ent638_1134	COG0371	Dehydrogenase
Ent638_1135	COG1129	ABC transporter
Ent638_1136	COG1172	Belongs to the binding-protein-dependent transport system permease family
Ent638_1139	COG4857	Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate
Ent638_1140	COG0182	Catalyzes the interconversion of methylthioribose-1- phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1- P)
Ent638_1141	COG1791	Catalyzes 2 different reactions between oxygene and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4- methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway
Ent638_1142	COG4229	Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK- MTPene)
Ent638_1143	COG0235	Class ii aldolase
Ent638_1144	COG0436	Aminotransferase
Ent638_1145	COG0450	alkyl hydroperoxide reductase
Ent638_1147	COG0589	response to stress
Ent638_1148	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
Ent638_1150	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
Ent638_1151	COG3719	Belongs to the RNase T2 family
Ent638_1152	COG3069	C4-dicarboxylate transmembrane transporter activity
Ent638_1156	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Ent638_1157	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
Ent638_1159	COG1278	Cold shock
Ent638_1160	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
Ent638_1161	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
Ent638_1163	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
Ent638_1164	COG0583	DNA-binding transcription factor activity
Ent638_1165	COG0321	lipoyl(octanoyl) transferase activity
Ent638_1166	COG2921	Belongs to the UPF0250 family
Ent638_1167	COG1686	Belongs to the peptidase S11 family
Ent638_1168	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
Ent638_1169	COG0772	Belongs to the SEDS family
Ent638_1170	COG0768	penicillin binding
Ent638_1171	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
Ent638_1172	COG0799	negative regulation of ribosome biogenesis
Ent638_1173	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
Ent638_1174	COG1466	dna polymerase III delta subunit
Ent638_1175	COG2980	Together with LptD, is involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane. Required for the proper assembly of LptD. Binds LPS and may serve as the LPS recognition site at the outer membrane
Ent638_1176	COG0495	leucyl-tRNA aminoacylation
Ent638_1177	COG2888	peptidyl-tyrosine sulfation
Ent638_1178	COG1957	nucleoside hydrolase
Ent638_1179	COG1126	abc transporter atp-binding protein
Ent638_1180	COG0765	amino acid transport
Ent638_1181	COG0765	amino acid transport
Ent638_1184	COG4535	Mg2 and Co2 transporter CorC
Ent638_1185	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
Ent638_1186	COG1702	phosphate starvation-inducible protein PhoH
Ent638_1187	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
Ent638_1188	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
Ent638_1189	COG0367	asparagine synthase
Ent638_1190	COG0647	UMP catabolic process
Ent638_1191	COG1846	Transcriptional regulator
Ent638_1191	COG1940	carbohydrate kinase activity
Ent638_1192	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
Ent638_1193	COG0363	glucosamine-6-phosphate deaminase activity
Ent638_1194	COG1263	PTS System
Ent638_1194	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
Ent638_1194	COG2190	(PTS) system
Ent638_1195	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
Ent638_1198	COG0735	belongs to the Fur family
Ent638_1201	COG0596	Alpha beta hydrolase
Ent638_1202	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
Ent638_1203	COG0033	Phosphoglucomutase
Ent638_1204	COG0531	amino acid
Ent638_1205	COG1982	Orn Lys Arg decarboxylase major
Ent638_1206	COG0745	RESPONSE REGULATOR receiver
Ent638_1207	COG2205	protein histidine kinase activity
Ent638_1208	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
Ent638_1209	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
Ent638_1210	COG2060	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds and transports the potassium across the cytoplasmic membrane
Ent638_1212	COG0415	Belongs to the DNA photolyase family
Ent638_1213	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
Ent638_1214	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
Ent638_1215	COG1984	allophanate hydrolase subunit 2
Ent638_1219	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
Ent638_1220	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
Ent638_1221	COG0372	Belongs to the citrate synthase family
Ent638_1222	COG2009	succinate dehydrogenase
Ent638_1223	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
Ent638_1224	COG1053	succinate dehydrogenase
Ent638_1225	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
Ent638_1226	COG0567	Dehydrogenase, E1 component
Ent638_1227	COG0508	dehydrogenase complex catalyzes the overall conversion of
Ent638_1228	COG0045	succinate-CoA ligase (ADP-forming) activity
Ent638_1229	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
Ent638_1230	COG1271	oxidase subunit
Ent638_1231	COG1294	oxidase, subunit
Ent638_1232	COG4890	Cyd operon protein YbgT
Ent638_1233	COG3790	cyd operon protein YbgE
Ent638_1234	COG0824	Thioesterase
Ent638_1235	COG0811	peptide transport
Ent638_1236	COG0848	biopolymer transport protein
Ent638_1237	COG3064	Membrane
Ent638_1238	COG0823	Involved in the tonB-independent uptake of proteins
Ent638_1239	COG2885	chlorophyll binding
Ent638_1240	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
Ent638_1241	COG0379	Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate
Ent638_1242	COG3201	nicotinamide mononucleotide transporter
Ent638_1245	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
Ent638_1246	COG0588	phosphoglycerate mutase activity
Ent638_1247	COG2017	converts alpha-aldose to the beta-anomer
Ent638_1248	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
Ent638_1249	COG1085	galactose-1-phosphate uridylyltransferase
Ent638_1250	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
Ent638_1251	COG1119	ATPase activity
Ent638_1252	COG2005	Transcriptional regulator
Ent638_1252	COG3585	molybdate ion transport
Ent638_1254	COG0725	ABC transporter, periplasmic molybdate-binding protein
Ent638_1255	COG4149	molybdate abc transporter
Ent638_1257	COG0561	phosphatase activity
Ent638_1258	COG2706	6-phosphogluconolactonase activity
Ent638_1259	COG4677	pectinesterase activity
Ent638_1261	COG0010	Belongs to the arginase family
Ent638_1263	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
Ent638_1264	COG2986	histidine ammonia-lyase
Ent638_1265	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
Ent638_1266	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
Ent638_1267	COG0156	8-amino-7-oxononanoate synthase activity
Ent638_1268	COG2226	methyltransferase
Ent638_1271	COG0556	nucleotide-excision repair
Ent638_1274	COG0521	Mo-molybdopterin cofactor biosynthetic process
Ent638_1275	COG0315	cyclic pyranopterin monophosphate synthase activity
Ent638_1276	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
Ent638_1277	COG0314	molybdopterin synthase activity
Ent638_1278	COG0670	Belongs to the BI1 family
Ent638_1279	COG0392	lysyltransferase activity
Ent638_1281	COG3568	Endonuclease Exonuclease Phosphatase
Ent638_1283	COG0842	Transport permease protein
Ent638_1284	COG0842	Transport permease protein
Ent638_1285	COG1131	(ABC) transporter
Ent638_1286	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Ent638_1287	COG1309	transcriptional regulator
Ent638_1288	COG0513	Belongs to the DEAD box helicase family
Ent638_1289	COG1199	ATP-dependent helicase activity
Ent638_1290	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
Ent638_1292	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
Ent638_1294	COG3129	Specifically methylates the adenine in position 1618 of 23S rRNA
Ent638_1295	COG0668	transmembrane transport
Ent638_1296	COG1126	abc transporter atp-binding protein
Ent638_1297	COG0765	amino acid transport
Ent638_1298	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Ent638_1299	COG0783	Belongs to the Dps family
Ent638_1301	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
Ent638_1302	COG2194	sulfuric ester hydrolase activity
Ent638_1304	COG1321	iron dependent repressor
Ent638_1305	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
Ent638_1306	COG0667	Aldo Keto reductase
Ent638_1307	COG2723	6-phospho-beta-galactosidase activity
Ent638_1308	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
Ent638_1309	COG2188	Transcriptional regulator
Ent638_1310	COG1376	ErfK ybiS ycfS ynhG family protein
Ent638_1311	COG0488	(ABC) transporter
Ent638_1313	COG2271	Major facilitator Superfamily
Ent638_1314	COG1609	Transcriptional regulator
Ent638_1316	COG0561	phosphatase activity
Ent638_1318	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
Ent638_1319	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
Ent638_1320	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
Ent638_1322	COG1446	asparaginase
Ent638_1324	COG0747	negative chemotaxis
Ent638_1326	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
Ent638_1328	COG2133	pyrroloquinoline quinone binding
Ent638_1329	COG0625	glutathione transferase activity
Ent638_1330	COG1686	Belongs to the peptidase S11 family
Ent638_1331	COG1349	DNA-binding transcription factor activity
Ent638_1332	COG0671	phosphoesterase, PA-phosphatase related
Ent638_1334	COG2814	Major facilitator Superfamily
Ent638_1335	COG0561	phosphatase activity
Ent638_1336	COG0738	Major facilitator superfamily
Ent638_1337	COG3226	Transcriptional regulator
Ent638_1338	COG3594	Acyltransferase
Ent638_1340	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
Ent638_1348	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
Ent638_1355	COG4695	Portal protein
Ent638_1362	COG2985	domain, Protein
Ent638_1362	COG0569	domain protein
Ent638_1364	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
Ent638_1366	COG0189	ligase activity
Ent638_1368	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
Ent638_1369	COG3842	ATPase activity
Ent638_1370	COG1176	ABC-type spermidine putrescine transport system, permease component I
Ent638_1371	COG1177	transmembrane transport
Ent638_1373	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
Ent638_1374	COG0745	RESPONSE REGULATOR receiver
Ent638_1375	COG5002	protein histidine kinase activity
Ent638_1376	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Ent638_1377	COG4160	amino acid transport
Ent638_1378	COG4215	(ABC) transporter
Ent638_1379	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Ent638_1380	COG1126	abc transporter atp-binding protein
Ent638_1382	COG0393	Putative heavy-metal-binding
Ent638_1383	COG3023	N-Acetylmuramoyl-L-alanine amidase
Ent638_1384	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Ent638_1385	COG0702	epimerase
Ent638_1386	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
Ent638_1387	COG0028	Belongs to the TPP enzyme family
Ent638_1389	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
Ent638_1390	COG1151	hydroxylamine reductase activity
Ent638_1391	COG2431	L-lysine efflux transmembrane transporter activity
Ent638_1392	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
Ent638_1393	COG3593	DNA synthesis involved in DNA repair
Ent638_1394	COG2990	Protein conserved in bacteria
Ent638_1395	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Ent638_1397	COG1278	Cold shock
Ent638_1398	COG2127	Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation
Ent638_1399	COG0542	response to heat
Ent638_1401	COG1518	maintenance of DNA repeat elements
Ent638_1402	COG1203	CRISPR-associated helicase, Cas3
Ent638_1407	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
Ent638_1409	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
Ent638_1410	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
Ent638_1411	COG4988	ABC transporter
Ent638_1412	COG0492	ferredoxin-NADP+ reductase activity
Ent638_1413	COG1522	sequence-specific DNA binding
Ent638_1414	COG1674	ftsk spoiiie
Ent638_1414	COG1178	ABC-type Fe3 transport system permease component
Ent638_1415	COG2834	Participates in the translocation of lipoproteins from the inner membrane to the outer membrane. Only forms a complex with a lipoprotein if the residue after the N-terminal Cys is not an aspartate (The Asp acts as a targeting signal to indicate that the lipoprotein should stay in the inner membrane)
Ent638_1416	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
Ent638_1417	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
Ent638_1418	COG0243	molybdopterin cofactor binding
Ent638_1419	COG0437	4 iron, 4 sulfur cluster binding
Ent638_1420	COG3302	dmso reductase anchor subunit
Ent638_1421	COG0477	Major facilitator Superfamily
Ent638_1422	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
Ent638_1423	COG1882	Formate acetyltransferase
Ent638_1424	COG2116	formate transmembrane transporter activity
Ent638_1425	COG1944	ATP diphosphatase activity
Ent638_1426	COG2323	membrane
Ent638_1427	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
Ent638_1428	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
Ent638_1429	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
Ent638_1430	COG0539	negative regulation of cytoplasmic translation
Ent638_1431	COG0776	regulation of translation
Ent638_1432	COG2333	competence protein COMEC
Ent638_1432	COG0658	competence protein
Ent638_1434	COG1663	tetraacyldisaccharide 4'-kinase activity
Ent638_1435	COG3214	Protein conserved in bacteria
Ent638_1436	COG2835	tetraacyldisaccharide 4'-kinase activity
Ent638_1437	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
Ent638_1438	COG3173	Aminoglycoside phosphotransferase
Ent638_1439	COG1434	Gram-negative-bacterium-type cell wall biogenesis
Ent638_1440	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
Ent638_1442	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
Ent638_1443	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
Ent638_1444	COG2989	Protein conserved in bacteria
Ent638_1445	COG3108	Peptidase M15
Ent638_1446	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Ent638_1447	COG1448	Aminotransferase
Ent638_1448	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
Ent638_1449	COG0017	Asparaginyl-tRNA synthetase
Ent638_1450	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
Ent638_1451	COG0308	aminopeptidase N
Ent638_1453	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
Ent638_1454	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
Ent638_1455	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
Ent638_1456	COG0431	NADPH-dependent FMN reductase
Ent638_1457	COG0167	dihydroorotate dehydrogenase activity
Ent638_1459	COG0633	Ferredoxin
Ent638_1459	COG3217	Mosc domain protein beta barrel domain protein
Ent638_1460	COG0116	Belongs to the methyltransferase superfamily
Ent638_1460	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
Ent638_1461	COG0488	(ABC) transporter
Ent638_1462	COG2995	paraquat-inducible protein a
Ent638_1463	COG3008	intermembrane lipid transfer
Ent638_1463	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
Ent638_1464	COG3009	Protein conserved in bacteria
Ent638_1465	COG3130	regulation of translation
Ent638_1466	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
Ent638_1467	COG1067	ATP-dependent peptidase activity
Ent638_1468	COG3120	sequence-specific DNA binding
Ent638_1470	COG5404	Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1 1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division
Ent638_1471	COG3070	regulator of competence-specific genes
Ent638_1472	COG1289	transmembrane transporter activity
Ent638_1473	COG3304	Inner membrane component domain
Ent638_1474	COG0210	DNA helicase
Ent638_1475	COG1803	Methylglyoxal synthase
Ent638_1476	COG3110	Uncharacterized protein conserved in bacteria (DUF2057)
Ent638_1477	COG1832	CoA-binding protein
Ent638_1479	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
Ent638_1480	COG1254	Belongs to the acylphosphatase family
Ent638_1482	COG0670	Belongs to the BI1 family
Ent638_1487	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
Ent638_1490	COG0300	oxidoreductase activity
Ent638_1495	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
Ent638_1497	COG0745	RESPONSE REGULATOR receiver
Ent638_1498	COG5002	protein histidine kinase activity
Ent638_1500	COG0024	Methionine aminopeptidase
Ent638_1506	COG3119	arylsulfatase activity
Ent638_1507	COG0641	radical SAM
Ent638_1510	COG1028	Short-chain dehydrogenase reductase Sdr
Ent638_1511	COG1733	regulation of RNA biosynthetic process
Ent638_1512	COG4221	oxidoreductase activity
Ent638_1513	COG1733	regulation of RNA biosynthetic process
Ent638_1516	COG0655	NAD(P)H dehydrogenase (quinone) activity
Ent638_1517	COG3729	General stress protein
Ent638_1519	COG2233	PERMEase
Ent638_1520	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
Ent638_1521	COG0778	Nitroreductase
Ent638_1522	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
Ent638_1523	COG0251	oxidation-reduction process
Ent638_1524	COG1335	isochorismatase
Ent638_1525	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
Ent638_1527	COG0583	DNA-binding transcription factor activity
Ent638_1529	COG3386	PFAM SMP-30 Gluconolaconase
Ent638_1530	COG3547	Transposase (IS116 IS110 IS902 family)
Ent638_1534	COG3300	MHYT domain
Ent638_1534	COG5001	Diguanylate cyclase
Ent638_1539	COG1309	transcriptional regulator
Ent638_1540	COG3755	Protein conserved in bacteria
Ent638_1541	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
Ent638_1541	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
Ent638_1541	COG0506	proline dehydrogenase activity
Ent638_1542	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
Ent638_1544	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
Ent638_1545	COG0672	)-iron permease
Ent638_1546	COG2822	iron ion transport
Ent638_1548	COG1702	phosphate starvation-inducible protein PhoH
Ent638_1549	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
Ent638_1550	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
Ent638_1551	COG3381	protein complex oligomerization
Ent638_1561	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
Ent638_1562	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
Ent638_1565	COG2943	transferase activity, transferring hexosyl groups
Ent638_1566	COG5645	(Lipo)protein
Ent638_1568	COG1560	Kdo2-lipid A biosynthetic process
Ent638_1570	COG2353	YceI-like domain
Ent638_1571	COG3038	cytochrome b561
Ent638_1576	COG0418	dihydroorotase activity
Ent638_1578	COG2999	glutathione oxidoreductase activity
Ent638_1579	COG0477	Major facilitator Superfamily
Ent638_1580	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
Ent638_1581	COG3132	Protein of unknown function, DUF480
Ent638_1582	COG0673	inositol 2-dehydrogenase activity
Ent638_1584	COG3418	PFAM FlgN family protein
Ent638_1588	COG1558	bacterial-type flagellum-dependent cell motility
Ent638_1589	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
Ent638_1590	COG1749	Flagellar hook protein flgE
Ent638_1592	COG4786	Flagellar basal body rod
Ent638_1596	COG1256	bacterial-type flagellum assembly
Ent638_1598	COG2814	Major facilitator Superfamily
Ent638_1599	COG0583	DNA-binding transcription factor activity
Ent638_1600	COG1530	ribonuclease E activity
Ent638_1602	COG0424	maF-like protein
Ent638_1603	COG1399	metal-binding, possibly nucleic acid-binding protein
Ent638_1604	COG0333	Belongs to the bacterial ribosomal protein bL32 family
Ent638_1605	COG0416	fatty acid biosynthetic process
Ent638_1606	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
Ent638_1608	COG1028	Short-chain dehydrogenase reductase Sdr
Ent638_1609	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
Ent638_1610	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
Ent638_1611	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
Ent638_1612	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
Ent638_1613	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
Ent638_1614	COG0470	DNA polymerase III
Ent638_1615	COG0084	hydrolase, TatD family'
Ent638_1616	COG1263	PTS System
Ent638_1616	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
Ent638_1617	COG4773	Receptor
Ent638_1618	COG0537	adenosine 5'-monophosphoramidase activity
Ent638_1619	COG5633	Lipoprotein
Ent638_1620	COG3417	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)
Ent638_1623	COG3150	esterase
Ent638_1624	COG1252	NADH dehydrogenase
Ent638_1625	COG3134	Outer membrane lipoprotein
Ent638_1626	COG1309	transcriptional regulator
Ent638_1628	COG1388	LysM domain
Ent638_1628	COG1376	ErfK ybiS ycfS ynhG family protein
Ent638_1629	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
Ent638_1630	COG4763	Acyl-transferase
Ent638_1631	COG4591	ABC-type transport system involved in lipoprotein release permease component
Ent638_1633	COG4591	ABC-type transport system involved in lipoprotein release permease component
Ent638_1635	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
Ent638_1636	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
Ent638_1637	COG1177	transmembrane transport
Ent638_1638	COG1176	ABC-type spermidine putrescine transport system, permease component I
Ent638_1641	COG2850	peptidyl-arginine hydroxylation
Ent638_1643	COG0745	RESPONSE REGULATOR receiver
Ent638_1644	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
Ent638_1645	COG2915	High frequency lysogenization protein hflD homolog
Ent638_1646	COG0482	sulfurtransferase activity
Ent638_1648	COG1187	pseudouridine synthase activity
Ent638_1649	COG0538	isocitrate dehydrogenase activity
Ent638_1650	COG0582	viral genome integration into host DNA
Ent638_1657	COG0840	transmembrane signaling receptor activity
Ent638_1658	COG2261	transglycosylase associated protein
Ent638_1659	COG2203	Gaf domain
Ent638_1659	COG2199	diguanylate cyclase activity
Ent638_1660	COG3042	response to heat
Ent638_1662	COG3189	MarR family transcriptional regulator
Ent638_1663	COG1683	Conserved Protein
Ent638_1664	COG0504	CTP synthase activity
Ent638_1665	COG2807	transmembrane transport
Ent638_1666	COG2207	Transcriptional regulator
Ent638_1667	COG2707	UPF0756 membrane protein
Ent638_1668	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
Ent638_1669	COG3706	GGDEF domain
Ent638_1670	COG2718	Belongs to the UPF0229 family
Ent638_1671	COG2766	serine protein kinase
Ent638_1672	COG3713	MltA-interacting MipA family protein
Ent638_1673	COG0656	L-ascorbic acid biosynthetic process
Ent638_1675	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
Ent638_1677	COG3139	Protein of unknown function (DUF1315)
Ent638_1678	COG1403	HNH endonuclease
Ent638_1679	COG1335	isochorismatase
Ent638_1680	COG0252	asparaginase activity
Ent638_1681	COG0616	signal peptide processing
Ent638_1682	COG0778	Nitroreductase
Ent638_1683	COG0709	Synthesizes selenophosphate from selenide and ATP
Ent638_1684	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
Ent638_1687	COG0494	nUDIX hydrolase
Ent638_1688	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
Ent638_1689	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
Ent638_1690	COG2897	thiosulfate sulfurtransferase activity
Ent638_1691	COG4136	ATPase activity
Ent638_1692	COG4135	transport system, permease component
Ent638_1693	COG4134	Bacterial extracellular solute-binding protein
Ent638_1695	COG0708	Exodeoxyribonuclease III
Ent638_1697	COG3138	arginine N-succinyltransferase
Ent638_1698	COG1012	belongs to the aldehyde dehydrogenase family
Ent638_1699	COG3724	N-succinylarginine dihydrolase activity
Ent638_1701	COG3678	ATP-independent chaperone mediated protein folding
Ent638_1703	COG0322	excinuclease ABC activity
Ent638_1704	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
Ent638_1705	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
Ent638_1706	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
Ent638_1707	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
Ent638_1708	COG1447	Phosphotransferase system cellobiose-specific component IIA
Ent638_1709	COG1917	Cupin 2, conserved barrel domain protein
Ent638_1709	COG2169	Transcriptional regulator
Ent638_1710	COG1486	melibiose metabolic process
Ent638_1711	COG3394	polysaccharide catabolic process
Ent638_1712	COG0753	catalase activity
Ent638_1715	COG1988	membrane-bound metal-dependent
Ent638_1716	COG1028	Short-chain dehydrogenase reductase Sdr
Ent638_1717	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
Ent638_1721	COG1105	Belongs to the carbohydrate kinase PfkB family
Ent638_1722	COG3137	Salt-induced outer membrane protein
Ent638_1724	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
Ent638_1726	COG0291	Belongs to the bacterial ribosomal protein bL35 family
Ent638_1727	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
Ent638_1728	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
Ent638_1730	COG0776	regulation of translation
Ent638_1732	COG0386	Belongs to the glutathione peroxidase family
Ent638_1734	COG0791	NLP P60 protein
Ent638_1736	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
Ent638_1738	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Ent638_1739	COG4558	Periplasmic binding protein
Ent638_1740	COG3720	iron ion transport
Ent638_1742	COG4256	Hemin uptake protein
Ent638_1743	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
Ent638_1744	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
Ent638_1745	COG0574	Belongs to the PEP-utilizing enzyme family
Ent638_1745	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
Ent638_1746	COG0628	permease
Ent638_1747	COG0247	lactate metabolic process
Ent638_1747	COG0277	FAD linked oxidase domain protein
Ent638_1748	COG2050	protein possibly involved in aromatic compounds catabolism
Ent638_1750	COG3383	formate dehydrogenase (NAD+) activity
Ent638_1750	COG0243	molybdopterin cofactor binding
Ent638_1751	COG0437	4 iron, 4 sulfur cluster binding
Ent638_1752	COG2864	formate dehydrogenase
Ent638_1753	COG3383	formate dehydrogenase (NAD+) activity
Ent638_1757	COG2200	EAL domain
Ent638_1758	COG0789	Transcriptional regulator
Ent638_1760	COG0316	Belongs to the HesB IscA family
Ent638_1761	COG0719	Fe-S assembly protein
Ent638_1762	COG0396	ATPase activity
Ent638_1763	COG0719	Fe-S assembly protein
Ent638_1764	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
Ent638_1765	COG2166	iron-sulfur cluster assembly
Ent638_1766	COG1376	ErfK ybiS ycfS ynhG family protein
Ent638_1769	COG0626	cystathionine gamma-synthase activity
Ent638_1772	COG2011	ABC-type metal ion transport system permease component
Ent638_1773	COG1464	Belongs to the NlpA lipoprotein family
Ent638_1776	COG0765	amino acid transport
Ent638_1777	COG0765	amino acid transport
Ent638_1779	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Ent638_1780	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
Ent638_1782	COG4529	Protein conserved in bacteria
Ent638_1783	COG0534	Mate efflux family protein
Ent638_1784	COG0307	riboflavin synthase, alpha
Ent638_1786	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
Ent638_1787	COG2814	Major facilitator Superfamily
Ent638_1788	COG0583	DNA-binding transcription factor activity
Ent638_1790	COG2814	Major facilitator Superfamily
Ent638_1791	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
Ent638_1792	COG0791	NLP P60 protein
Ent638_1793	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
Ent638_1794	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
Ent638_1795	COG0346	lactoylglutathione lyase activity
Ent638_1796	COG1902	pentaerythritol trinitrate reductase activity
Ent638_1797	COG1309	transcriptional regulator
Ent638_1798	COG2194	sulfuric ester hydrolase activity
Ent638_1799	COG3313	Fe-S protein
Ent638_1800	COG4989	oxidoreductase activity
Ent638_1801	COG2032	superoxide dismutase activity
Ent638_1803	COG1566	PFAM secretion protein HlyD family protein
Ent638_1806	COG3706	GGDEF domain
Ent638_1807	COG3133	Outer membrane lipoprotein
Ent638_1808	COG2377	Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling
Ent638_1809	COG3895	Periplasmic Protein
Ent638_1810	COG0259	pyridoxamine-phosphate oxidase activity
Ent638_1811	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
Ent638_1812	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
Ent638_1813	COG0625	glutathione transferase activity
Ent638_1814	COG3104	oligopeptide transport
Ent638_1815	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
Ent638_1824	COG0673	inositol 2-dehydrogenase activity
Ent638_1825	COG1816	Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism
Ent638_1826	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
Ent638_1827	COG1263	PTS System
Ent638_1827	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
Ent638_1828	COG1609	Transcriptional regulator
Ent638_1829	COG5339	Protein conserved in bacteria
Ent638_1830	COG1482	cell wall glycoprotein biosynthetic process
Ent638_1831	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
Ent638_1831	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
Ent638_1834	COG0747	negative chemotaxis
Ent638_1835	COG0601	transmembrane transport
Ent638_1836	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
Ent638_1838	COG1124	(ABC) transporter
Ent638_1839	COG0864	Transcriptional regulator
Ent638_1840	COG2205	protein histidine kinase activity
Ent638_1844	COG0745	RESPONSE REGULATOR receiver
Ent638_1845	COG3136	membrane protein required for alginate biosynthesis
Ent638_1846	COG1028	Short-chain dehydrogenase reductase Sdr
Ent638_1847	COG0531	amino acid
Ent638_1849	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
Ent638_1850	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
Ent638_1851	COG0589	response to stress
Ent638_1854	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
Ent638_1855	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
Ent638_1857	COG2840	Smr protein MutS2
Ent638_1859	COG0667	Aldo Keto reductase
Ent638_1861	COG0745	RESPONSE REGULATOR receiver
Ent638_1865	COG0596	Alpha beta hydrolase
Ent638_1867	COG5295	Hep Hag repeat protein
Ent638_1876	COG0667	Aldo Keto reductase
Ent638_1879	COG0583	DNA-binding transcription factor activity
Ent638_1882	COG0583	DNA-binding transcription factor activity
Ent638_1885	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
Ent638_1887	COG3141	response to X-ray
Ent638_1889	COG0583	DNA-binding transcription factor activity
Ent638_1890	COG3708	Transcriptional regulator
Ent638_1890	COG2207	Transcriptional regulator
Ent638_1891	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Ent638_1896	COG1605	Chorismate mutase
Ent638_1907	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
Ent638_1908	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
Ent638_1910	COG0628	permease
Ent638_1911	COG2076	Multidrug Resistance protein
Ent638_1912	COG2076	Multidrug Resistance protein
Ent638_1913	COG5001	Diguanylate cyclase
Ent638_1914	COG3591	Belongs to the peptidase S1B family
Ent638_1916	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
Ent638_1917	COG2814	Major facilitator Superfamily
Ent638_1918	COG0583	DNA-binding transcription factor activity
Ent638_1919	COG1940	carbohydrate kinase activity
Ent638_1920	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
Ent638_1925	COG3381	protein complex oligomerization
Ent638_1929	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
Ent638_1931	COG1742	UPF0060 membrane protein
Ent638_1932	COG4948	Mandelate Racemase Muconate Lactonizing
Ent638_1933	COG1063	alcohol dehydrogenase
Ent638_1934	COG0477	Major facilitator Superfamily
Ent638_1935	COG0246	Mannitol dehydrogenase
Ent638_1937	COG0589	response to stress
Ent638_1938	COG1802	Transcriptional regulator
Ent638_1939	COG4221	oxidoreductase activity
Ent638_1942	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
Ent638_1943	COG2911	Protein conserved in bacteria
Ent638_1945	COG3784	Protein of unknown function (DUF1318)
Ent638_1946	COG5001	Diguanylate cyclase
Ent638_1946	COG3706	GGDEF domain
Ent638_1946	COG2203	Gaf domain
Ent638_1946	COG4251	negative regulation of phosphorylation
Ent638_1948	COG1643	Atp-dependent helicase
Ent638_1949	COG1538	Outer membrane efflux protein
Ent638_1952	COG1434	Gram-negative-bacterium-type cell wall biogenesis
Ent638_1953	COG1012	belongs to the aldehyde dehydrogenase family
Ent638_1954	COG0657	acetylesterase activity
Ent638_1954	COG2755	lipolytic protein G-D-S-L family
Ent638_1955	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
Ent638_1956	COG3038	cytochrome b561
Ent638_1958	COG0477	Major facilitator Superfamily
Ent638_1961	COG0840	transmembrane signaling receptor activity
Ent638_1963	COG4993	Dehydrogenase
Ent638_1964	COG0583	DNA-binding transcription factor activity
Ent638_1965	COG5383	Protein conserved in bacteria
Ent638_1966	COG2272	Belongs to the type-B carboxylesterase lipase family
Ent638_1968	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
Ent638_1969	COG0436	Aminotransferase
Ent638_1971	COG3131	Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs)
Ent638_1972	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
Ent638_1973	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
Ent638_1974	COG1275	C4-dicarboxylate transporter malic acid transport protein
Ent638_1975	COG0500	methyltransferase
Ent638_1976	COG2195	Cleaves the N-terminal amino acid of tripeptides
Ent638_1977	COG0747	negative chemotaxis
Ent638_1980	COG2169	Transcriptional regulator
Ent638_1980	COG1917	Cupin 2, conserved barrel domain protein
Ent638_1981	COG3135	benzoate transporter
Ent638_1982	COG1396	sequence-specific DNA binding
Ent638_1983	COG0826	peptidase U32
Ent638_1987	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
Ent638_1989	COG0559	Belongs to the binding-protein-dependent transport system permease family
Ent638_1993	COG3443	Belongs to the bacterial solute-binding protein 9 family
Ent638_1994	COG2814	Major facilitator Superfamily
Ent638_1995	COG0697	spore germination
Ent638_1998	COG1846	Transcriptional regulator
Ent638_2000	COG2814	Major facilitator Superfamily
Ent638_2002	COG0039	L-malate dehydrogenase activity
Ent638_2004	COG0583	DNA-binding transcription factor activity
Ent638_2005	COG1012	belongs to the aldehyde dehydrogenase family
Ent638_2006	COG0840	transmembrane signaling receptor activity
Ent638_2007	COG2066	Belongs to the glutaminase family
Ent638_2009	COG2199	diguanylate cyclase activity
Ent638_2011	COG2203	Gaf domain
Ent638_2011	COG2199	diguanylate cyclase activity
Ent638_2013	COG0246	Mannitol dehydrogenase
Ent638_2014	COG3781	membrane
Ent638_2018	COG4106	trans-aconitate 2-methyltransferase activity
Ent638_2029	COG4628	conserved protein (DUF2132)
Ent638_2031	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
Ent638_2032	COG2200	EAL domain
Ent638_2033	COG3550	peptidyl-serine autophosphorylation
Ent638_2034	COG1396	sequence-specific DNA binding
Ent638_2035	COG1733	regulation of RNA biosynthetic process
Ent638_2036	COG2814	Major facilitator Superfamily
Ent638_2039	COG1028	Short-chain dehydrogenase reductase Sdr
Ent638_2040	COG0583	DNA-binding transcription factor activity
Ent638_2041	COG1764	response to oxidative stress
Ent638_2047	COG0281	malic enzyme
Ent638_2048	COG0488	(ABC) transporter
Ent638_2050	COG2814	Major facilitator Superfamily
Ent638_2052	COG2864	formate dehydrogenase
Ent638_2053	COG0437	4 iron, 4 sulfur cluster binding
Ent638_2054	COG0243	molybdopterin cofactor binding
Ent638_2054	COG3383	formate dehydrogenase (NAD+) activity
Ent638_2055	COG3383	formate dehydrogenase (NAD+) activity
Ent638_2055	COG0243	molybdopterin cofactor binding
Ent638_2061	COG2223	nitrite transmembrane transporter activity
Ent638_2062	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
Ent638_2063	COG1140	nitrate reductase beta subunit
Ent638_2064	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
Ent638_2065	COG2181	nitrate reductase activity
Ent638_2066	COG2336	PFAM SpoVT AbrB
Ent638_2067	COG2337	Toxic component of a toxin-antitoxin (TA) module
Ent638_2068	COG2162	N-hydroxyarylamine O-acetyltransferase activity
Ent638_2069	COG1178	ABC-type Fe3 transport system permease component
Ent638_2070	COG1840	ABC-type Fe3 transport system, periplasmic component
Ent638_2071	COG3842	ATPase activity
Ent638_2072	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
Ent638_2073	COG2076	Multidrug Resistance protein
Ent638_2074	COG2076	Multidrug Resistance protein
Ent638_2075	COG1807	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family
Ent638_2076	COG0726	polysaccharide deacetylase
Ent638_2077	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
Ent638_2077	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Ent638_2078	COG0463	Glycosyl transferase, family 2
Ent638_2079	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
Ent638_2081	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
Ent638_2082	COG0640	Transcriptional regulator
Ent638_2084	COG1942	4-Oxalocrotonate Tautomerase
Ent638_2086	COG1126	abc transporter atp-binding protein
Ent638_2087	COG0765	amino acid transport
Ent638_2090	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
Ent638_2092	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
Ent638_2093	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
Ent638_2094	COG0840	transmembrane signaling receptor activity
Ent638_2099	COG4772	TonB-dependent receptor
Ent638_2101	COG1802	Transcriptional regulator
Ent638_2102	COG2130	NADP-dependent
Ent638_2104	COG1247	-acetyltransferase
Ent638_2105	COG3238	Protein conserved in bacteria
Ent638_2107	COG0747	negative chemotaxis
Ent638_2115	COG5434	Belongs to the glycosyl hydrolase 28 family
Ent638_2119	COG0840	transmembrane signaling receptor activity
Ent638_2121	COG3615	Tellurite resistance protein tehB
Ent638_2122	COG3615	Tellurite resistance protein tehB
Ent638_2124	COG1012	belongs to the aldehyde dehydrogenase family
Ent638_2125	COG1177	transmembrane transport
Ent638_2126	COG1176	ABC-type spermidine putrescine transport system, permease component I
Ent638_2127	COG3842	ATPase activity
Ent638_2128	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
Ent638_2129	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
Ent638_2131	COG1271	oxidase subunit
Ent638_2132	COG1294	oxidase, subunit
Ent638_2134	COG3187	Heat shock protein
Ent638_2135	COG3042	response to heat
Ent638_2136	COG0674	pyruvate-flavodoxin oxidoreductase activity
Ent638_2136	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Ent638_2136	COG1013	pyruvate-flavodoxin oxidoreductase activity
Ent638_2136	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
Ent638_2139	COG0840	transmembrane signaling receptor activity
Ent638_2140	COG3706	GGDEF domain
Ent638_2141	COG0582	viral genome integration into host DNA
Ent638_2142	COG0037	tRNA processing
Ent638_2143	COG0513	Belongs to the DEAD box helicase family
Ent638_2144	COG0598	Magnesium transport protein CorA
Ent638_2145	COG0840	transmembrane signaling receptor activity
Ent638_2147	COG3706	GGDEF domain
Ent638_2148	COG4166	transmembrane transport
Ent638_2149	COG2866	Carboxypeptidase
Ent638_2150	COG4948	Mandelate Racemase Muconate Lactonizing
Ent638_2151	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
Ent638_2152	COG3283	Transcriptional regulator of aromatic amino acids metabolism
Ent638_2153	COG3768	UPF0283 membrane protein
Ent638_2154	COG3106	COG3106 Predicted ATPase
Ent638_2155	COG1609	Transcriptional regulator
Ent638_2157	COG3842	ATPase activity
Ent638_2158	COG1554	hydrolase, family 65, central catalytic
Ent638_2159	COG0673	inositol 2-dehydrogenase activity
Ent638_2160	COG1082	Xylose isomerase domain protein TIM barrel
Ent638_2161	COG1063	alcohol dehydrogenase
Ent638_2162	COG0395	ABC-type sugar transport system, permease component
Ent638_2163	COG1175	transmembrane transport
Ent638_2164	COG1653	transport
Ent638_2165	COG0366	Alpha amylase catalytic
Ent638_2167	COG1983	PspC domain protein
Ent638_2169	COG1842	Phage shock protein A
Ent638_2170	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
Ent638_2172	COG4168	peptide transport system, permease
Ent638_2173	COG4171	peptide transport system, permease
Ent638_2175	COG4172	Belongs to the ABC transporter superfamily
Ent638_2179	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
Ent638_2179	COG4950	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
Ent638_2180	COG4776	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
Ent638_2181	COG5001	Diguanylate cyclase
Ent638_2182	COG1024	Enoyl-CoA hydratase
Ent638_2184	COG1349	DNA-binding transcription factor activity
Ent638_2186	COG0023	Translation Initiation Factor
Ent638_2187	COG0284	orotidine-5'-phosphate decarboxylase activity
Ent638_2188	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
Ent638_2189	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
Ent638_2190	COG0671	phosphoesterase, PA-phosphatase related
Ent638_2191	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
Ent638_2192	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
Ent638_2196	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
Ent638_2198	COG0616	signal peptide processing
Ent638_2199	COG1028	Short-chain dehydrogenase reductase Sdr
Ent638_2200	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
Ent638_2201	COG1187	pseudouridine synthase activity
Ent638_2202	COG0009	L-threonylcarbamoyladenylate synthase
Ent638_2203	COG0613	PHP domain protein
Ent638_2205	COG0512	Glutamine amidotransferase of anthranilate synthase
Ent638_2205	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
Ent638_2207	COG0133	tryptophan synthase activity
Ent638_2208	COG0159	tryptophan synthase activity
Ent638_2209	COG2135	peptidase activity
Ent638_2210	COG2135	peptidase activity
Ent638_2211	COG0653	protein targeting
Ent638_2248	COG3772	lysozyme
Ent638_2253	COG1403	HNH endonuclease
Ent638_2254	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
Ent638_2267	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
Ent638_2269	COG0582	viral genome integration into host DNA
Ent638_2270	COG2391	methyltransferase activity
Ent638_2271	COG0425	Belongs to the sulfur carrier protein TusA family
Ent638_2274	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
Ent638_2275	COG0640	Transcriptional regulator
Ent638_2277	COG1902	pentaerythritol trinitrate reductase activity
Ent638_2281	COG0604	alcohol dehydrogenase
Ent638_2282	COG3477	response to acidic pH
Ent638_2283	COG3047	cAMP biosynthetic process
Ent638_2285	COG2917	probably involved in intracellular septation
Ent638_2286	COG1607	acyl-coa hydrolase
Ent638_2288	COG2350	Protein conserved in bacteria
Ent638_2291	COG0583	DNA-binding transcription factor activity
Ent638_2293	COG1280	lysine exporter protein (LysE YggA)
Ent638_2295	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
Ent638_2296	COG3099	Belongs to the UPF0263 family
Ent638_2297	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
Ent638_2299	COG0444	Belongs to the ABC transporter superfamily
Ent638_2302	COG4166	transmembrane transport
Ent638_2303	COG2095	MarC family integral membrane protein
Ent638_2304	COG1454	alcohol dehydrogenase
Ent638_2304	COG1012	belongs to the aldehyde dehydrogenase family
Ent638_2307	COG1210	Utp--glucose-1-phosphate uridylyltransferase
Ent638_2308	COG0745	RESPONSE REGULATOR receiver
Ent638_2309	COG1752	Esterase of the alpha-beta hydrolase superfamily
Ent638_2310	COG3012	SEC-C Motif Domain Protein
Ent638_2311	COG0788	formyltetrahydrofolate deformylase activity
Ent638_2312	COG2181	nitrate reductase activity
Ent638_2313	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
Ent638_2314	COG1140	nitrate reductase beta subunit
Ent638_2315	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
Ent638_2316	COG2223	nitrite transmembrane transporter activity
Ent638_2317	COG3850	Histidine kinase
Ent638_2318	COG2197	response regulator
Ent638_2319	COG4932	domain protein
Ent638_2321	COG0243	molybdopterin cofactor binding
Ent638_2322	COG2146	nitrite reductase [NAD(P)H] activity
Ent638_2322	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
Ent638_2323	COG1116	anion transmembrane transporter activity
Ent638_2325	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
Ent638_2326	COG3707	response regulator
Ent638_2327	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
Ent638_2328	COG0840	transmembrane signaling receptor activity
Ent638_2330	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
Ent638_2331	COG4572	Cation transport regulator
Ent638_2332	COG0387	Pfam Sodium calcium exchanger
Ent638_2333	COG2877	3-deoxy-8-phosphooctulonate synthase activity
Ent638_2334	COG2912	Transglutaminase-like superfamily
Ent638_2335	COG3094	Invasion gene expression up-regulator, SirB
Ent638_2337	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
Ent638_2338	COG0373	Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)
Ent638_2339	COG3017	Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein
Ent638_2340	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
Ent638_2341	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
Ent638_2342	COG0659	secondary active sulfate transmembrane transporter activity
Ent638_2344	COG0193	aminoacyl-tRNA hydrolase activity
Ent638_2345	COG0012	GTP binding
Ent638_2347	COG0243	molybdopterin cofactor binding
Ent638_2348	COG2207	Transcriptional regulator
Ent638_2353	COG2814	Major facilitator Superfamily
Ent638_2356	COG4774	siderophore transport
Ent638_2359	COG0741	lytic transglycosylase activity
Ent638_2360	COG1619	proteins homologs of microcin C7 resistance protein MccF
Ent638_2361	COG3263	regulation of cellular component size
Ent638_2362	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
Ent638_2363	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
Ent638_2364	COG2719	SpoVR family
Ent638_2365	COG2186	Transcriptional regulator
Ent638_2366	COG3067	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
Ent638_2368	COG2983	Belongs to the UPF0260 family
Ent638_2369	COG0179	Fumarylacetoacetate (FAA) hydrolase
Ent638_2370	COG3100	YcgL domain-containing protein
Ent638_2371	COG0850	regulation of cytokinetic process
Ent638_2372	COG2894	cell division
Ent638_2373	COG0851	Prevents the cell division inhibition by proteins MinC and MinD at internal division sites while permitting inhibition at polar sites. This ensures cell division at the proper site by restricting the formation of a division septum at the midpoint of the long axis of the cell
Ent638_2374	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
Ent638_2375	COG0318	PFAM AMP-dependent synthetase and ligase
Ent638_2376	COG3065	identical protein binding
Ent638_2378	COG1199	ATP-dependent helicase activity
Ent638_2379	COG0251	oxidation-reduction process
Ent638_2380	COG3140	Belongs to the UPF0181 family
Ent638_2381	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
Ent638_2382	COG0494	nUDIX hydrolase
Ent638_2383	COG1760	l-serine dehydratase
Ent638_2384	COG2200	EAL domain
Ent638_2385	COG1253	flavin adenine dinucleotide binding
Ent638_2386	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
Ent638_2386	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
Ent638_2387	COG3715	PTS system
Ent638_2388	COG3716	PTS system mannose fructose sorbose family IID component
Ent638_2389	COG4811	Protein of unknown function (DUF986)
Ent638_2390	COG1971	Probably functions as a manganese efflux pump
Ent638_2391	COG2226	methyltransferase
Ent638_2392	COG0768	penicillin binding
Ent638_2393	COG1278	Cold shock
Ent638_2397	COG1414	Transcriptional regulator
Ent638_2398	COG2814	Major facilitator Superfamily
Ent638_2399	COG0501	Belongs to the peptidase M48B family
Ent638_2401	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
Ent638_2402	COG1956	GAF domain-containing protein
Ent638_2403	COG2995	paraquat-inducible protein a
Ent638_2404	COG3008	intermembrane lipid transfer
Ent638_2405	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
Ent638_2405	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
Ent638_2409	COG2990	Protein conserved in bacteria
Ent638_2411	COG1276	copper resistance
Ent638_2412	COG2372	response to copper ion
Ent638_2414	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
Ent638_2415	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
Ent638_2416	COG1770	oligopeptidase
Ent638_2417	COG2979	Protein of unknown function (DUF533)
Ent638_2419	COG0800	Aldolase
Ent638_2420	COG0129	dihydroxy-acid dehydratase activity
Ent638_2421	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
Ent638_2422	COG1737	Transcriptional regulator
Ent638_2423	COG0469	pyruvate kinase activity
Ent638_2424	COG1560	Kdo2-lipid A biosynthetic process
Ent638_2425	COG0739	heme binding
Ent638_2426	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
Ent638_2428	COG1108	ABC-type Mn2 Zn2 transport systems permease components
Ent638_2429	COG2255	four-way junction helicase activity
Ent638_2430	COG0632	four-way junction helicase activity
Ent638_2431	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
Ent638_2432	COG0217	transcriptional regulatory protein
Ent638_2433	COG0494	nUDIX hydrolase
Ent638_2434	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
Ent638_2435	COG1335	isochorismatase
Ent638_2436	COG1801	Protein of unknown function DUF72
Ent638_2437	COG3788	relative of glutathione S-transferase, MAPEG superfamily
Ent638_2438	COG2226	methyltransferase
Ent638_2439	COG0500	methyltransferase
Ent638_2440	COG3142	Participates in the control of copper homeostasis
Ent638_2441	COG3102	Protein conserved in bacteria
Ent638_2442	COG0018	arginyl-trna synthetase
Ent638_2443	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
Ent638_2449	COG3121	Chaperone
Ent638_2450	COG3188	usher protein
Ent638_2451	COG3539	Fimbrial protein
Ent638_2453	COG0745	RESPONSE REGULATOR receiver
Ent638_2456	COG0840	transmembrane signaling receptor activity
Ent638_2463	COG1301	dicarboxylic acid transport
Ent638_2472	COG0380	Probably involved in the osmoprotection via the biosynthesis of trehalose. Catalyzes the transfer of glucose from UDP-glucose (UDP-Glc) to D-glucose 6-phosphate (Glc-6-P) to form trehalose-6-phosphate. Acts with retention of the anomeric configuration of the UDP-sugar donor
Ent638_2474	COG1172	Belongs to the binding-protein-dependent transport system permease family
Ent638_2476	COG1879	ABC-type sugar transport system periplasmic component
Ent638_2478	COG1528	Iron-storage protein
Ent638_2479	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
Ent638_2482	COG0477	Major facilitator Superfamily
Ent638_2484	COG3437	response regulator, receiver
Ent638_2486	COG1528	Iron-storage protein
Ent638_2489	COG0814	amino acid
Ent638_2490	COG3318	Belongs to the UPF0149 family
Ent638_2490	COG3012	SEC-C Motif Domain Protein
Ent638_2492	COG0559	Belongs to the binding-protein-dependent transport system permease family
Ent638_2495	COG0410	ABC transporter
Ent638_2497	COG1278	Cold shock
Ent638_2498	COG1278	Cold shock
Ent638_2499	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
Ent638_2501	COG2197	response regulator
Ent638_2503	COG2197	response regulator
Ent638_2506	COG2515	1-aminocyclopropane-1-carboxylate deaminase
Ent638_2509	COG1191	sigma factor activity
Ent638_2512	COG0318	PFAM AMP-dependent synthetase and ligase
Ent638_2513	COG3958	Transketolase
Ent638_2514	COG3959	Transketolase, thiamine diphosphate binding domain
Ent638_2515	COG1028	Short-chain dehydrogenase reductase Sdr
Ent638_2516	COG1028	Short-chain dehydrogenase reductase Sdr
Ent638_2523	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
Ent638_2526	COG0366	Alpha amylase catalytic
Ent638_2528	COG1677	Flagellar hook-basal body complex protein FliE
Ent638_2530	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
Ent638_2532	COG1157	protein secretion by the type III secretion system
Ent638_2533	COG2882	bacterial-type flagellum organization
Ent638_2538	COG3190	flagellar
Ent638_2540	COG1987	bacterial-type flagellum assembly
Ent638_2542	COG2197	response regulator
Ent638_2547	COG5475	Uncharacterized small protein (DUF2158)
Ent638_2548	COG2354	Protein conserved in bacteria
Ent638_2549	COG0697	spore germination
Ent638_2550	COG3727	T/G mismatch-specific endonuclease activity
Ent638_2551	COG0270	DNA (cytosine-5-)-methyltransferase activity
Ent638_2552	COG1418	mRNA catabolic process
Ent638_2553	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
Ent638_2555	COG3290	protein histidine kinase activity
Ent638_2556	COG4565	transcriptional regulatory protein
Ent638_2558	COG1053	succinate dehydrogenase
Ent638_2560	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
Ent638_2560	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
Ent638_2561	COG3228	Belongs to the MtfA family
Ent638_2566	COG0589	response to stress
Ent638_2568	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
Ent638_2571	COG0477	Major facilitator Superfamily
Ent638_2572	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
Ent638_2573	COG0006	proline dipeptidase activity
Ent638_2574	COG0534	Mate efflux family protein
Ent638_2575	COG2926	Belongs to the UPF0265 family
Ent638_2576	COG1289	transmembrane transporter activity
Ent638_2577	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
Ent638_2583	COG3778	Protein conserved in bacteria
Ent638_2584	COG3299	homolog of phage Mu protein gp47
Ent638_2588	COG4228	DNA circulation
Ent638_2592	COG4386	tail sheath protein
Ent638_2602	COG4626	Terminase
Ent638_2602	COG1802	Transcriptional regulator
Ent638_2609	COG3772	lysozyme
Ent638_2611	COG1598	PFAM Uncharacterised protein family UPF0150
Ent638_2614	COG1403	HNH endonuclease
Ent638_2626	COG0582	viral genome integration into host DNA
Ent638_2627	COG2925	Exonuclease
Ent638_2628	COG0531	amino acid
Ent638_2629	COG0583	DNA-binding transcription factor activity
Ent638_2630	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Ent638_2631	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
Ent638_2633	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
Ent638_2635	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
Ent638_2636	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
Ent638_2637	COG0107	imidazoleglycerol-phosphate synthase activity
Ent638_2638	COG0140	phosphoribosyl-ATP diphosphatase activity
Ent638_2638	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
Ent638_2642	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
Ent638_2643	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
Ent638_2644	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
Ent638_2644	COG0662	Cupin 2, conserved barrel domain protein
Ent638_2654	COG0110	maltose O-acetyltransferase activity
Ent638_2656	COG1210	Utp--glucose-1-phosphate uridylyltransferase
Ent638_2658	COG0438	transferase activity, transferring glycosyl groups
Ent638_2659	COG2327	Polysaccharide pyruvyl transferase
Ent638_2660	COG2244	polysaccharide biosynthetic process
Ent638_2661	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
Ent638_2662	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
Ent638_2664	COG0297	glycogen (starch) synthase activity
Ent638_2665	COG1051	belongs to the nudix hydrolase family
Ent638_2666	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
Ent638_2667	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
Ent638_2668	COG0110	maltose O-acetyltransferase activity
Ent638_2669	COG1216	Glycosyl transferase, family 2
Ent638_2671	COG0438	transferase activity, transferring glycosyl groups
Ent638_2672	COG1045	serine acetyltransferase
Ent638_2673	COG0463	Glycosyl transferase, family 2
Ent638_2674	COG3206	protein involved in exopolysaccharide biosynthesis
Ent638_2674	COG0489	protein tyrosine kinase activity
Ent638_2676	COG1596	polysaccharide export
Ent638_2677	COG1253	flavin adenine dinucleotide binding
Ent638_2678	COG2982	Protein involved in outer membrane biogenesis
Ent638_2679	COG0717	Belongs to the dCTP deaminase family
Ent638_2680	COG0572	uridine kinase
Ent638_2681	COG5002	protein histidine kinase activity
Ent638_2681	COG5001	Diguanylate cyclase
Ent638_2681	COG3447	MASE1 domain protein
Ent638_2682	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
Ent638_2683	COG0443	Heat shock 70 kDa protein
Ent638_2684	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Ent638_2685	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
Ent638_2686	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
Ent638_2687	COG0477	Major facilitator Superfamily
Ent638_2688	COG2205	protein histidine kinase activity
Ent638_2689	COG0745	RESPONSE REGULATOR receiver
Ent638_2692	COG1309	transcriptional regulator
Ent638_2694	COG2814	Major facilitator Superfamily
Ent638_2699	COG0386	Belongs to the glutathione peroxidase family
Ent638_2701	COG1597	lipid kinase activity
Ent638_2702	COG4608	Belongs to the ABC transporter superfamily
Ent638_2703	COG0444	Belongs to the ABC transporter superfamily
Ent638_2705	COG0601	transmembrane transport
Ent638_2706	COG0747	negative chemotaxis
Ent638_2707	COG4948	Mandelate Racemase Muconate Lactonizing
Ent638_2708	COG1830	Aldolase
Ent638_2710	COG0351	phosphomethylpyrimidine kinase
Ent638_2711	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
Ent638_2713	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
Ent638_2714	COG0076	glutamate decarboxylase activity
Ent638_2716	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
Ent638_2717	COG1596	polysaccharide export
Ent638_2718	COG5455	response to cobalt ion
Ent638_2720	COG0489	protein tyrosine kinase activity
Ent638_2721	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Ent638_2721	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
Ent638_2722	COG4807	Protein conserved in bacteria
Ent638_2724	COG3275	phosphorelay sensor kinase activity
Ent638_2725	COG0789	Transcriptional regulator
Ent638_2727	COG1174	glycine betaine transport
Ent638_2728	COG1125	glycine betaine transport
Ent638_2729	COG1174	glycine betaine transport
Ent638_2730	COG1732	Glycine betaine
Ent638_2731	COG1472	Belongs to the glycosyl hydrolase 3 family
Ent638_2732	COG0277	FAD linked oxidase domain protein
Ent638_2734	COG1686	Belongs to the peptidase S11 family
Ent638_2736	COG0586	Pfam SNARE associated Golgi protein
Ent638_2737	COG1028	Short-chain dehydrogenase reductase Sdr
Ent638_2738	COG1538	Outer membrane efflux protein
Ent638_2739	COG2723	6-phospho-beta-galactosidase activity
Ent638_2742	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
Ent638_2744	COG1380	Effector of murein hydrolase LrgA
Ent638_2745	COG1346	cytolysis
Ent638_2746	COG0295	cytidine deaminase activity
Ent638_2747	COG2949	membrane
Ent638_2748	COG4211	Belongs to the binding-protein-dependent transport system permease family
Ent638_2749	COG1129	ABC transporter
Ent638_2752	COG2311	Membrane
Ent638_2753	COG0302	gtp cyclohydrolase
Ent638_2754	COG0477	Major facilitator Superfamily
Ent638_2755	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
Ent638_2756	COG4771	TonB-dependent receptor
Ent638_2757	COG0833	amino acid
Ent638_2758	COG0583	DNA-binding transcription factor activity
Ent638_2759	COG2855	membrane
Ent638_2760	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
Ent638_2761	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
Ent638_2761	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
Ent638_2761	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
Ent638_2762	COG1105	Belongs to the carbohydrate kinase PfkB family
Ent638_2766	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
Ent638_2767	COG1312	Catalyzes the dehydration of D-mannonate
Ent638_2768	COG0246	Mannitol dehydrogenase
Ent638_2769	COG0523	cobalamin synthesis protein
Ent638_2770	COG0671	phosphoesterase, PA-phosphatase related
Ent638_2771	COG0791	NLP P60 protein
Ent638_2772	COG2200	EAL domain
Ent638_2773	COG4166	transmembrane transport
Ent638_2774	COG4174	ABC transporter (Permease)
Ent638_2775	COG4239	(ABC) transporter, permease
Ent638_2776	COG4172	Belongs to the ABC transporter superfamily
Ent638_2778	COG2814	Major facilitator Superfamily
Ent638_2779	COG1187	pseudouridine synthase activity
Ent638_2780	COG1061	Type III restriction enzyme res subunit
Ent638_2781	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
Ent638_2782	COG3081	Nucleoid-associated protein
Ent638_2783	COG3082	Protein of unknown function (DUF1414)
Ent638_2786	COG3182	Iron-regulated membrane protein
Ent638_2787	COG4574	serine-type endopeptidase inhibitor activity
Ent638_2788	COG0579	oxidoreductase
Ent638_2789	COG0659	secondary active sulfate transmembrane transporter activity
Ent638_2790	COG2239	Acts as a magnesium transporter
Ent638_2791	COG4615	Cyclic peptide transporter
Ent638_2792	COG3145	DNA-N1-methyladenine dioxygenase activity
Ent638_2793	COG2169	Transcriptional regulator
Ent638_2793	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
Ent638_2794	COG1477	protein flavinylation
Ent638_2795	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
Ent638_2796	COG0642	Histidine kinase
Ent638_2796	COG2198	Histidine kinase
Ent638_2797	COG2197	response regulator
Ent638_2798	COG0784	Response regulator, receiver
Ent638_2798	COG2205	protein histidine kinase activity
Ent638_2800	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
Ent638_2803	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
Ent638_2804	COG2271	Major facilitator Superfamily
Ent638_2805	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
Ent638_2806	COG3075	Conversion of glycerol 3-phosphate to dihydroxyacetone. Uses fumarate or nitrate as electron acceptor
Ent638_2807	COG0247	lactate metabolic process
Ent638_2811	COG1441	menaquinone biosynthetic process
Ent638_2813	COG0596	Alpha beta hydrolase
Ent638_2814	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
Ent638_2815	COG1169	isochorismate synthase
Ent638_2816	COG4575	ribosome binding
Ent638_2817	COG2153	protein acetylation
Ent638_2818	COG1234	tRNA 3'-trailer cleavage
Ent638_2819	COG0835	chemotaxis
Ent638_2819	COG0784	Response regulator, receiver
Ent638_2820	COG1007	ATP synthesis coupled electron transport
Ent638_2821	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Ent638_2822	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
Ent638_2823	COG0713	ATP synthesis coupled electron transport
Ent638_2824	COG0839	Belongs to the complex I subunit 6 family
Ent638_2825	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Ent638_2826	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
Ent638_2827	COG1034	ATP synthesis coupled electron transport
Ent638_2829	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
Ent638_2830	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Ent638_2830	COG0649	NAD binding
Ent638_2831	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Ent638_2832	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Ent638_2833	COG0583	DNA-binding transcription factor activity
Ent638_2834	COG0436	Aminotransferase
Ent638_2835	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
Ent638_2836	COG0490	domain, Protein
Ent638_2836	COG0471	metal ion transport
Ent638_2837	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
Ent638_2838	COG3013	Belongs to the UPF0304 family
Ent638_2839	COG3092	negative regulation of chromosome organization
Ent638_2840	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
Ent638_2842	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
Ent638_2843	COG3959	Transketolase, thiamine diphosphate binding domain
Ent638_2844	COG3037	sugar-specific permease SgaT UlaA
Ent638_2846	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
Ent638_2847	COG1609	Transcriptional regulator
Ent638_2848	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
Ent638_2849	COG0622	Phosphoesterase
Ent638_2850	COG0625	glutathione transferase activity
Ent638_2851	COG0625	glutathione transferase activity
Ent638_2852	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
Ent638_2853	COG1090	epimerase
Ent638_2854	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
Ent638_2855	COG4598	ABC transporter
Ent638_2856	COG4160	amino acid transport
Ent638_2857	COG4215	(ABC) transporter
Ent638_2858	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Ent638_2860	COG0163	prenyltransferase activity
Ent638_2861	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
Ent638_2862	COG1286	toxin biosynthetic process
Ent638_2863	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
Ent638_2864	COG0285	dihydrofolate synthase activity
Ent638_2865	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
Ent638_2866	COG0586	Pfam SNARE associated Golgi protein
Ent638_2867	COG0101	tRNA pseudouridine synthase activity
Ent638_2868	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
Ent638_2869	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
Ent638_2871	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
Ent638_2872	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
Ent638_2872	COG4121	Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34
Ent638_2874	COG3101	peptidyl-lysine hydroxylation
Ent638_2875	COG0730	response to heat
Ent638_2877	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
Ent638_2878	COG2890	protein-(glutamine-N5) methyltransferase activity
Ent638_2879	COG2840	Smr protein MutS2
Ent638_2880	COG2062	phosphohistidine phosphatase, SixA
Ent638_2881	COG1250	3-hydroxyacyl-CoA dehydrogenase
Ent638_2881	COG1024	Enoyl-CoA hydratase
Ent638_2882	COG0183	Belongs to the thiolase family
Ent638_2883	COG3691	Protein conserved in bacteria
Ent638_2884	COG2067	long-chain fatty acid transport protein
Ent638_2886	COG2116	formate transmembrane transporter activity
Ent638_2887	COG0582	viral genome integration into host DNA
Ent638_2889	COG1475	DNA binding
Ent638_2902	COG4974	Belongs to the 'phage' integrase family
Ent638_2917	COG1560	Kdo2-lipid A biosynthetic process
Ent638_2918	COG0436	Aminotransferase
Ent638_2919	COG3275	phosphorelay sensor kinase activity
Ent638_2920	COG3279	Response regulator of the LytR AlgR family
Ent638_2921	COG0837	glucose binding
Ent638_2923	COG3961	Belongs to the TPP enzyme family
Ent638_2924	COG0667	Aldo Keto reductase
Ent638_2926	COG1914	H( )-stimulated, divalent metal cation uptake system
Ent638_2927	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
Ent638_2928	COG2200	EAL domain
Ent638_2928	COG2199	diguanylate cyclase activity
Ent638_2929	COG3415	Transposase
Ent638_2930	COG3415	Transposase
Ent638_2931	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
Ent638_2932	COG0583	DNA-binding transcription factor activity
Ent638_2933	COG2211	Major facilitator Superfamily
Ent638_2934	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
Ent638_2936	COG0583	DNA-binding transcription factor activity
Ent638_2937	COG0385	Bile acid
Ent638_2938	COG3530	Putative quorum-sensing-regulated virulence factor
Ent638_2939	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
Ent638_2940	COG3115	cell septum assembly
Ent638_2942	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
Ent638_2943	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
Ent638_2945	COG2190	(PTS) system
Ent638_2948	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
Ent638_2949	COG4208	sulfate ABC transporter
Ent638_2950	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
Ent638_2951	COG4150	thiosulfate binding
Ent638_2952	COG2837	iron assimilation
Ent638_2956	COG0860	N-Acetylmuramoyl-L-alanine amidase
Ent638_2957	COG0408	coproporphyrinogen oxidase activity
Ent638_2960	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
Ent638_2961	COG5342	invasion associated locus B
Ent638_2962	COG0494	nUDIX hydrolase
Ent638_2963	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
Ent638_2963	COG0493	'glutamate synthase
Ent638_2964	COG3850	Histidine kinase
Ent638_2965	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
Ent638_2966	COG1393	Belongs to the ArsC family
Ent638_2967	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
Ent638_2969	COG0400	carboxylic ester hydrolase activity
Ent638_2970	COG1444	tRNA N-acetyltransferase activity
Ent638_2971	COG2321	neutral zinc metallopeptidase
Ent638_2972	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
Ent638_2973	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
Ent638_2975	COG2716	regulation of RNA biosynthetic process
Ent638_2976	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
Ent638_2977	COG0628	permease
Ent638_2978	COG4783	chaperone-mediated protein folding
Ent638_2979	COG1393	Belongs to the ArsC family
Ent638_2981	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
Ent638_2982	COG1446	asparaginase
Ent638_2983	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
Ent638_2985	COG2233	PERMEase
Ent638_2986	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
Ent638_2987	COG2723	6-phospho-beta-galactosidase activity
Ent638_2988	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
Ent638_2989	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
Ent638_2991	COG0248	Ppx GppA phosphatase
Ent638_2992	COG2200	EAL domain
Ent638_2994	COG0583	DNA-binding transcription factor activity
Ent638_2996	COG3507	Belongs to the glycosyl hydrolase 43 family
Ent638_2997	COG2211	Major facilitator Superfamily
Ent638_2998	COG0518	GMP synthase (glutamine-hydrolyzing) activity
Ent638_2998	COG0519	Catalyzes the synthesis of GMP from XMP
Ent638_2999	COG0517	IMP dehydrogenase activity
Ent638_2999	COG0516	GMP reductase activity
Ent638_3000	COG1570	exodeoxyribonuclease VII activity
Ent638_3001	COG1645	bacterial-type flagellum-dependent swarming motility
Ent638_3005	COG1160	GTP binding
Ent638_3007	COG2976	Protein conserved in bacteria
Ent638_3008	COG0124	histidyl-tRNA synthetase
Ent638_3009	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
Ent638_3010	COG1426	Protein conserved in bacteria
Ent638_3011	COG0820	rRNA (adenine-C2-)-methyltransferase activity
Ent638_3012	COG0105	UTP biosynthetic process
Ent638_3013	COG4953	penicillin-binding protein 1C
Ent638_3014	COG2373	Large extracellular alpha-helical protein
Ent638_3015	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
Ent638_3015	COG2190	(PTS) system
Ent638_3015	COG1263	PTS System
Ent638_3017	COG2897	thiosulfate sulfurtransferase activity
Ent638_3018	COG1737	Transcriptional regulator
Ent638_3020	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
Ent638_3021	COG2975	iron-sulfur cluster assembly
Ent638_3022	COG0633	Ferredoxin
Ent638_3023	COG0443	Heat shock 70 kDa protein
Ent638_3024	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
Ent638_3025	COG0316	Belongs to the HesB IscA family
Ent638_3026	COG0822	iron-sulfur transferase activity
Ent638_3027	COG1104	cysteine desulfurase activity
Ent638_3028	COG1959	2 iron, 2 sulfur cluster binding
Ent638_3031	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
Ent638_3032	COG3683	transport system, periplasmic component
Ent638_3033	COG3711	transcriptional antiterminator
Ent638_3034	COG2814	Major facilitator Superfamily
Ent638_3035	COG2259	Doxx family
Ent638_3036	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
Ent638_3037	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
Ent638_3037	COG1017	nitric oxide dioxygenase activity
Ent638_3038	COG0347	Belongs to the P(II) protein family
Ent638_3039	COG2204	response regulator
Ent638_3040	COG3170	Tfp pilus assembly protein FimV
Ent638_3041	COG2205	protein histidine kinase activity
Ent638_3042	COG0047	phosphoribosylformylglycinamidine synthase activity
Ent638_3042	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
Ent638_3043	COG4623	carbon-oxygen lyase activity, acting on polysaccharides
Ent638_3044	COG0590	tRNA wobble adenosine to inosine editing
Ent638_3045	COG0560	Phosphoserine phosphatase
Ent638_3046	COG1263	PTS System
Ent638_3046	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
Ent638_3047	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
Ent638_3048	COG1737	Transcriptional regulator
Ent638_3049	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
Ent638_3050	COG0736	holo-[acyl-carrier-protein] synthase activity
Ent638_3051	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
Ent638_3052	COG1381	Involved in DNA repair and RecF pathway recombination
Ent638_3053	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
Ent638_3054	COG0571	ribonuclease III activity
Ent638_3055	COG0681	Belongs to the peptidase S26 family
Ent638_3056	COG0481	GTPase activity
Ent638_3057	COG3086	response to oxidative stress
Ent638_3061	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
Ent638_3062	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
Ent638_3063	COG0513	Belongs to the DEAD box helicase family
Ent638_3064	COG3445	Acts as a radical domain for damaged PFL and possibly other radical proteins
Ent638_3065	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
Ent638_3066	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
Ent638_3067	COG3118	belongs to the thioredoxin family
Ent638_3070	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
Ent638_3071	COG5544	Lipoprotein
Ent638_3072	COG0542	response to heat
Ent638_3074	COG0564	pseudouridine synthase activity
Ent638_3075	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
Ent638_3076	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
Ent638_3077	COG0077	Prephenate dehydratase
Ent638_3077	COG1605	Chorismate mutase
Ent638_3079	COG1605	Chorismate mutase
Ent638_3079	COG0287	Prephenate dehydrogenase
Ent638_3080	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
Ent638_3083	COG2199	diguanylate cyclase activity
Ent638_3084	COG2885	chlorophyll binding
Ent638_3087	COG0335	large ribosomal subunit rRNA binding
Ent638_3088	COG0336	Belongs to the RNA methyltransferase TrmD family
Ent638_3089	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
Ent638_3090	COG0228	four-way junction DNA binding
Ent638_3091	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
Ent638_3092	COG4137	Cytochrome C assembly protein
Ent638_3093	COG4536	flavin adenine dinucleotide binding
Ent638_3094	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
Ent638_3095	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
Ent638_3096	COG0497	DNA recombination
Ent638_3099	COG2867	negative regulation of translational initiation
Ent638_3100	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
Ent638_3101	COG0582	viral genome integration into host DNA
Ent638_3122	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Ent638_3123	COG1051	belongs to the nudix hydrolase family
Ent638_3125	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
Ent638_3126	COG3729	General stress protein
Ent638_3127	COG3685	Protein conserved in bacteria
Ent638_3128	COG3685	Protein conserved in bacteria
Ent638_3129	COG3546	catalase activity
Ent638_3130	COG1271	oxidase subunit
Ent638_3131	COG1294	oxidase, subunit
Ent638_3132	COG1546	Belongs to the CinA family
Ent638_3135	COG3111	PFAM Bacterial OB fold (BOF) protein
Ent638_3137	COG0583	DNA-binding transcription factor activity
Ent638_3139	COG2226	methyltransferase
Ent638_3140	COG0402	S-adenosylhomocysteine deaminase activity
Ent638_3141	COG0549	Belongs to the carbamate kinase family
Ent638_3143	COG1304	FMN binding
Ent638_3144	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
Ent638_3145	COG0666	response to abiotic stimulus
Ent638_3146	COG0583	DNA-binding transcription factor activity
Ent638_3147	COG0401	homolog of Blt101
Ent638_3149	COG2916	Histone family protein nucleoid-structuring protein H-NS
Ent638_3152	COG4575	ribosome binding
Ent638_3154	COG1780	Probably involved in ribonucleotide reductase function
Ent638_3157	COG4175	Glycine betaine
Ent638_3158	COG4176	ABC-type proline glycine betaine transport system permease component
Ent638_3161	COG2814	Major facilitator Superfamily
Ent638_3162	COG1846	Transcriptional regulator
Ent638_3163	COG1566	PFAM secretion protein HlyD family protein
Ent638_3164	COG2814	Major facilitator Superfamily
Ent638_3165	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
Ent638_3167	COG1854	S-ribosylhomocysteine lyase activity
Ent638_3168	COG2918	glutathione biosynthetic process
Ent638_3169	COG1238	metal cluster binding
Ent638_3170	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
Ent638_3172	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
Ent638_3173	COG2137	regulation of response to DNA damage stimulus
Ent638_3174	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
Ent638_3175	COG1546	Belongs to the CinA family
Ent638_3177	COG1108	ABC-type Mn2 Zn2 transport systems permease components
Ent638_3179	COG2951	lytic endotransglycosylase activity
Ent638_3180	COG0517	IMP dehydrogenase activity
Ent638_3180	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
Ent638_3181	COG3604	Transcriptional regulator
Ent638_3182	COG1773	rubredoxin
Ent638_3182	COG0426	domain, Protein
Ent638_3183	COG0446	pyridine nucleotide-disulphide oxidoreductase
Ent638_3184	COG3376	Belongs to the NiCoT transporter (TC 2.A.52) family
Ent638_3185	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
Ent638_3186	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
Ent638_3187	COG1609	Transcriptional regulator
Ent638_3188	COG1263	PTS System
Ent638_3188	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
Ent638_3189	COG2723	6-phospho-beta-galactosidase activity
Ent638_3190	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
Ent638_3192	COG3260	NADH ubiquinone oxidoreductase 20
Ent638_3193	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
Ent638_3194	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
Ent638_3194	COG3261	NADH dehydrogenase
Ent638_3195	COG0650	Formate hydrogenlyase subunit 4
Ent638_3196	COG0651	ATP synthesis coupled electron transport
Ent638_3197	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
Ent638_3199	COG0375	protein maturation
Ent638_3200	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
Ent638_3201	COG0298	carbon dioxide binding
Ent638_3202	COG0409	Hydrogenase expression formation protein
Ent638_3203	COG0309	Hydrogenase expression formation protein (HypE)
Ent638_3206	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Ent638_3207	COG1120	ATPase activity
Ent638_3211	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
Ent638_3212	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
Ent638_3213	COG1388	LysM domain
Ent638_3213	COG4942	peptidase
Ent638_3214	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
Ent638_3215	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
Ent638_3216	COG0585	pseudouridine synthase activity
Ent638_3217	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
Ent638_3218	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
Ent638_3219	COG2919	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic
Ent638_3221	COG0529	Catalyzes the synthesis of activated sulfate
Ent638_3223	COG0175	sulfate reduction
Ent638_3224	COG2234	aminopeptidase activity
Ent638_3225	COG0175	sulfate reduction
Ent638_3226	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
Ent638_3227	COG0369	Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component
Ent638_3228	COG0720	synthase
Ent638_3229	COG0602	queuosine metabolic process
Ent638_3230	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
Ent638_3231	COG2190	(PTS) system
Ent638_3231	COG1263	PTS System
Ent638_3231	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
Ent638_3233	COG0148	phosphopyruvate hydratase activity
Ent638_3234	COG0504	CTP synthase activity
Ent638_3235	COG3956	TIGRFAM MazG family protein
Ent638_3236	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
Ent638_3237	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
Ent638_3238	COG4999	Histidine kinase
Ent638_3238	COG3850	Histidine kinase
Ent638_3238	COG3437	response regulator, receiver
Ent638_3238	COG2205	protein histidine kinase activity
Ent638_3239	COG1929	Belongs to the glycerate kinase type-1 family
Ent638_3240	COG4948	Mandelate Racemase Muconate Lactonizing
Ent638_3241	COG4948	Mandelate Racemase Muconate Lactonizing
Ent638_3242	COG2271	Major facilitator Superfamily
Ent638_3243	COG0716	FMN binding
Ent638_3244	COG0564	pseudouridine synthase activity
Ent638_3245	COG3098	single-species biofilm formation
Ent638_3248	COG1611	Belongs to the LOG family
Ent638_3249	COG0814	amino acid
Ent638_3250	COG1760	l-serine dehydratase
Ent638_3252	COG2933	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. RlmM subfamily
Ent638_3253	COG2363	Small membrane protein
Ent638_3254	COG0583	DNA-binding transcription factor activity
Ent638_3256	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
Ent638_3257	COG2166	iron-sulfur cluster assembly
Ent638_3258	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
Ent638_3259	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
Ent638_3260	COG0860	N-Acetylmuramoyl-L-alanine amidase
Ent638_3261	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
Ent638_3261	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
Ent638_3262	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
Ent638_3263	COG1074	ATP-dependent DNA helicase activity
Ent638_3265	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
Ent638_3266	COG4967	type IV pilus modification protein PilV
Ent638_3267	COG4795	General secretion pathway protein
Ent638_3268	COG2165	general secretion pathway protein
Ent638_3269	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
Ent638_3270	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
Ent638_3272	COG0494	nUDIX hydrolase
Ent638_3273	COG3066	DNA modification
Ent638_3275	COG0667	Aldo Keto reductase
Ent638_3276	COG0477	Major facilitator Superfamily
Ent638_3277	COG0318	PFAM AMP-dependent synthetase and ligase
Ent638_3277	COG0204	Acyl-transferase
Ent638_3278	COG1609	Transcriptional regulator
Ent638_3280	COG2186	Transcriptional regulator
Ent638_3281	COG2723	6-phospho-beta-galactosidase activity
Ent638_3282	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
Ent638_3283	COG1609	Transcriptional regulator
Ent638_3284	COG0019	diaminopimelate decarboxylase activity
Ent638_3285	COG0583	DNA-binding transcription factor activity
Ent638_3286	COG1794	racemase activity, acting on amino acids and derivatives
Ent638_3289	COG1175	transmembrane transport
Ent638_3290	COG0395	ABC-type sugar transport system, permease component
Ent638_3291	COG3842	ATPase activity
Ent638_3293	COG0823	Involved in the tonB-independent uptake of proteins
Ent638_3294	COG2814	Major facilitator Superfamily
Ent638_3295	COG1028	Short-chain dehydrogenase reductase Sdr
Ent638_3296	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
Ent638_3297	COG0823	Involved in the tonB-independent uptake of proteins
Ent638_3298	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
Ent638_3299	COG0183	Belongs to the thiolase family
Ent638_3300	COG0583	DNA-binding transcription factor activity
Ent638_3302	COG0814	amino acid
Ent638_3304	COG2388	GCN5-related N-acetyl-transferase
Ent638_3305	COG3592	Divergent 4Fe-4S mono-cluster
Ent638_3306	COG4942	peptidase
Ent638_3307	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
Ent638_3308	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
Ent638_3310	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
Ent638_3312	COG4974	Belongs to the 'phage' integrase family
Ent638_3313	COG0716	FMN binding
Ent638_3315	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
Ent638_3316	COG0354	folic acid binding
Ent638_3317	COG1272	protein, Hemolysin III
Ent638_3319	COG1737	Transcriptional regulator
Ent638_3320	COG2723	6-phospho-beta-galactosidase activity
Ent638_3321	COG1028	Short-chain dehydrogenase reductase Sdr
Ent638_3322	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
Ent638_3322	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
Ent638_3323	COG0509	glycine decarboxylation via glycine cleavage system
Ent638_3324	COG0404	The glycine cleavage system catalyzes the degradation of glycine
Ent638_3325	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
Ent638_3326	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
Ent638_3327	COG0006	proline dipeptidase activity
Ent638_3329	COG3027	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. It is recruited early at mid-cell but it is not essential for cell division
Ent638_3331	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
Ent638_3332	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
Ent638_3333	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
Ent638_3334	COG0583	DNA-binding transcription factor activity
Ent638_3335	COG2968	Membrane
Ent638_3336	COG1279	arginine transmembrane transporter activity
Ent638_3337	COG0668	transmembrane transport
Ent638_3338	COG0191	fructose-bisphosphate aldolase activity
Ent638_3339	COG0126	phosphoglycerate kinase activity
Ent638_3340	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
Ent638_3341	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
Ent638_3342	COG0501	Belongs to the peptidase M48B family
Ent638_3343	COG0010	Belongs to the arginase family
Ent638_3344	COG1166	arginine decarboxylase activity
Ent638_3346	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
Ent638_3347	COG2814	Major facilitator Superfamily
Ent638_3348	COG3091	SprT-like family
Ent638_3349	COG2356	endonuclease I
Ent638_3350	COG1385	rRNA (uridine-N3-)-methyltransferase activity
Ent638_3351	COG0189	ligase activity
Ent638_3353	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
Ent638_3356	COG2805	Type II/IV secretion system protein
Ent638_3357	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
Ent638_3358	COG0762	integral membrane protein
Ent638_3359	COG1872	DUF167
Ent638_3360	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
Ent638_3361	COG0635	Involved in the biosynthesis of porphyrin-containing compound
Ent638_3362	COG2852	Protein conserved in bacteria
Ent638_3364	COG3171	Protein conserved in bacteria
Ent638_3366	COG1194	a g-specific adenine glycosylase
Ent638_3367	COG2924	Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes
Ent638_3368	COG0741	lytic transglycosylase activity
Ent638_3369	COG2211	Major facilitator Superfamily
Ent638_3370	COG1767	triphosphoribosyl-dephospho-CoA synthase activity
Ent638_3374	COG3052	prosthetic group binding
Ent638_3376	COG0179	Fumarylacetoacetate (FAA) hydrolase
Ent638_3377	COG3493	citrate carrier protein
Ent638_3380	COG1982	Orn Lys Arg decarboxylase major
Ent638_3381	COG1811	Na channel or pump
Ent638_3385	COG4625	pathogenesis
Ent638_3386	COG3647	Membrane
Ent638_3390	COG4232	protein-disulfide reductase activity
Ent638_3393	COG0754	glutathionylspermidine amidase activity
Ent638_3394	COG0625	glutathione transferase activity
Ent638_3397	COG0668	transmembrane transport
Ent638_3398	COG0628	permease
Ent638_3400	COG2197	response regulator
Ent638_3404	COG2199	diguanylate cyclase activity
Ent638_3404	COG2203	Gaf domain
Ent638_3405	COG1349	DNA-binding transcription factor activity
Ent638_3407	COG0840	transmembrane signaling receptor activity
Ent638_3410	COG0667	Aldo Keto reductase
Ent638_3411	COG2862	Uncharacterized protein family, UPF0114
Ent638_3415	COG1028	Short-chain dehydrogenase reductase Sdr
Ent638_3416	COG0848	biopolymer transport protein
Ent638_3417	COG0811	peptide transport
Ent638_3418	COG0626	cystathionine gamma-synthase activity
Ent638_3419	COG0586	Pfam SNARE associated Golgi protein
Ent638_3420	COG2207	Transcriptional regulator
Ent638_3422	COG1979	alcohol dehydrogenase
Ent638_3424	COG1032	radical SAM domain protein
Ent638_3425	COG2132	Multicopper oxidase
Ent638_3426	COG0204	Acyl-transferase
Ent638_3428	COG3111	PFAM Bacterial OB fold (BOF) protein
Ent638_3429	COG0745	RESPONSE REGULATOR receiver
Ent638_3431	COG2249	NAD(P)H dehydrogenase (quinone) activity
Ent638_3432	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
Ent638_3433	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
Ent638_3434	COG2211	Major facilitator Superfamily
Ent638_3439	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Ent638_3440	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
Ent638_3441	COG1120	ATPase activity
Ent638_3442	COG4774	siderophore transport
Ent638_3443	COG0187	DNA topoisomerase II activity
Ent638_3444	COG3150	esterase
Ent638_3445	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
Ent638_3446	COG3151	Protein conserved in bacteria
Ent638_3447	COG0494	nUDIX hydrolase
Ent638_3448	COG1538	Outer membrane efflux protein
Ent638_3450	COG0754	glutathionylspermidine amidase activity
Ent638_3451	COG3384	dioxygenase
Ent638_3452	COG0428	transporter
Ent638_3453	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
Ent638_3455	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
Ent638_3455	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
Ent638_3457	COG3025	triphosphatase activity
Ent638_3458	COG4991	sh3 domain protein
Ent638_3459	COG0617	tRNA 3'-terminal CCA addition
Ent638_3460	COG1968	undecaprenyl-diphosphatase activity
Ent638_3461	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
Ent638_3462	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
Ent638_3463	COG0829	nickel cation binding
Ent638_3464	COG0831	urea catabolic process
Ent638_3465	COG0832	Belongs to the urease beta subunit family
Ent638_3466	COG0804	urea catabolic process
Ent638_3467	COG2371	Involved in urease metallocenter assembly. Binds nickel. Probably functions as a nickel donor during metallocenter assembly
Ent638_3468	COG0830	nickel cation binding
Ent638_3469	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
Ent638_3470	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
Ent638_3472	COG0358	DNA primase activity
Ent638_3473	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
Ent638_3474	COG3663	DNA glycosylase
Ent638_3483	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
Ent638_3502	COG4695	Portal protein
Ent638_3507	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
Ent638_3514	COG4974	Belongs to the 'phage' integrase family
Ent638_3519	COG0251	oxidation-reduction process
Ent638_3520	COG1309	transcriptional regulator
Ent638_3524	COG2375	cellular response to nickel ion
Ent638_3525	COG1695	Transcriptional regulator
Ent638_3527	COG0840	transmembrane signaling receptor activity
Ent638_3528	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
Ent638_3531	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
Ent638_3532	COG1830	Aldolase
Ent638_3533	COG1879	ABC-type sugar transport system periplasmic component
Ent638_3534	COG1172	Belongs to the binding-protein-dependent transport system permease family
Ent638_3535	COG1172	Belongs to the binding-protein-dependent transport system permease family
Ent638_3536	COG1129	ABC transporter
Ent638_3537	COG2390	Transcriptional regulator
Ent638_3538	COG1070	Carbohydrate kinase
Ent638_3539	COG0446	pyridine nucleotide-disulphide oxidoreductase
Ent638_3539	COG1902	pentaerythritol trinitrate reductase activity
Ent638_3540	COG2813	Specifically methylates the guanine in position
Ent638_3541	COG1451	nucleotide metabolic process
Ent638_3542	COG0673	inositol 2-dehydrogenase activity
Ent638_3544	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
Ent638_3545	COG2721	sulfolactate sulfo-lyase activity
Ent638_3547	COG2271	Major facilitator Superfamily
Ent638_3548	COG2186	Transcriptional regulator
Ent638_3549	COG0586	Pfam SNARE associated Golgi protein
Ent638_3551	COG1422	Protein of unknown function (DUF1090)
Ent638_3552	COG4575	ribosome binding
Ent638_3553	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
Ent638_3555	COG2259	Doxx family
Ent638_3556	COG0435	Glutathione S-transferase
Ent638_3557	COG3152	Membrane
Ent638_3558	COG0583	DNA-binding transcription factor activity
Ent638_3559	COG1741	Belongs to the pirin family
Ent638_3561	COG1882	Formate acetyltransferase
Ent638_3562	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
Ent638_3563	COG0814	amino acid
Ent638_3565	COG0583	DNA-binding transcription factor activity
Ent638_3566	COG1929	Belongs to the glycerate kinase type-1 family
Ent638_3567	COG2084	Dehydrogenase
Ent638_3568	COG3836	Belongs to the HpcH HpaI aldolase family
Ent638_3569	COG2271	Major facilitator Superfamily
Ent638_3570	COG2721	sulfolactate sulfo-lyase activity
Ent638_3571	COG1349	DNA-binding transcription factor activity
Ent638_3572	COG4573	that is required for full activity and stability of the Y subunit. Could have a chaperone-like function for the proper and stable folding of
Ent638_3573	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
Ent638_3575	COG3716	PTS system mannose fructose sorbose family IID component
Ent638_3576	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
Ent638_3577	COG2222	sugar isomerase
Ent638_3578	COG0191	fructose-bisphosphate aldolase activity
Ent638_3579	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
Ent638_3580	COG3715	PTS system
Ent638_3581	COG3716	PTS system mannose fructose sorbose family IID component
Ent638_3582	COG0363	glucosamine-6-phosphate deaminase activity
Ent638_3583	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
Ent638_3584	COG3107	peptidoglycan biosynthetic process
Ent638_3585	COG0792	nuclease activity
Ent638_3586	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
Ent638_3587	COG2823	Periplasmic or secreted lipoprotein
Ent638_3588	COG0701	Predicted permease
Ent638_3589	COG0702	epimerase
Ent638_3590	COG0693	protein deglycase activity
Ent638_3591	COG3787	Belongs to the UPF0306 family
Ent638_3592	COG2827	Endonuclease containing a URI domain
Ent638_3593	COG3153	acetyltransferase
Ent638_3597	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
Ent638_3598	COG0814	amino acid
Ent638_3601	COG1185	polyribonucleotide nucleotidyltransferase activity
Ent638_3603	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
Ent638_3604	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
Ent638_3605	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
Ent638_3606	COG0195	Participates in both transcription termination and antitermination
Ent638_3607	COG0779	Required for maturation of 30S ribosomal subunits
Ent638_3608	COG0137	argininosuccinate synthase activity
Ent638_3610	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
Ent638_3611	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
Ent638_3612	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
Ent638_3613	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
Ent638_3614	COG1534	Rna-binding protein
Ent638_3615	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
Ent638_3616	COG2027	D-alanyl-D-alanine carboxypeptidase
Ent638_3617	COG0745	RESPONSE REGULATOR receiver
Ent638_3618	COG0642	Histidine kinase
Ent638_3619	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
Ent638_3620	COG0697	spore germination
Ent638_3621	COG0211	Belongs to the bacterial ribosomal protein bL27 family
Ent638_3622	COG0261	This protein binds to 23S rRNA in the presence of protein L20
Ent638_3623	COG0142	geranyltranstransferase activity
Ent638_3624	COG3423	Transcriptional regulator
Ent638_3625	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
Ent638_3626	COG5007	Belongs to the BolA IbaG family
Ent638_3627	COG3113	response to antibiotic
Ent638_3628	COG2854	intermembrane phospholipid transfer
Ent638_3629	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
Ent638_3630	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
Ent638_3631	COG1127	ABC transporter
Ent638_3632	COG0530	calcium, potassium:sodium antiporter activity
Ent638_3634	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
Ent638_3635	COG3117	lipopolysaccharide transmembrane transporter activity
Ent638_3636	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
Ent638_3637	COG1137	ATPase activity
Ent638_3640	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
Ent638_3641	COG1660	Displays ATPase and GTPase activities
Ent638_3642	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
Ent638_3644	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
Ent638_3645	COG5002	protein histidine kinase activity
Ent638_3645	COG0784	Response regulator, receiver
Ent638_3645	COG2198	Histidine kinase
Ent638_3646	COG0795	lipopolysaccharide-transporting ATPase activity
Ent638_3647	COG0795	lipopolysaccharide-transporting ATPase activity
Ent638_3648	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
Ent638_3649	COG2927	DNA polymerase III (CHI subunit)
Ent638_3652	COG1064	alcohol dehydrogenase
Ent638_3654	COG0433	COG0433 Predicted ATPase
Ent638_3655	COG1242	4 iron, 4 sulfur cluster binding
Ent638_3656	COG0070	glutamate synthase
Ent638_3656	COG0069	glutamate synthase activity
Ent638_3656	COG0067	glutamate synthase
Ent638_3657	COG0493	'glutamate synthase
Ent638_3658	COG2731	YhcH YjgK YiaL family protein
Ent638_3660	COG2814	Major facilitator Superfamily
Ent638_3661	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
Ent638_3662	COG2186	Transcriptional regulator
Ent638_3663	COG2969	positive regulation of protein catabolic process
Ent638_3664	COG0625	glutathione transferase activity
Ent638_3665	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
Ent638_3667	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
Ent638_3668	COG3105	Protein conserved in bacteria
Ent638_3669	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Ent638_3670	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
Ent638_3671	COG0039	L-malate dehydrogenase activity
Ent638_3672	COG1438	arginine binding
Ent638_3675	COG2732	(Barnase) inhibitor
Ent638_3677	COG1289	transmembrane transporter activity
Ent638_3678	COG1566	PFAM secretion protein HlyD family protein
Ent638_3680	COG0583	DNA-binding transcription factor activity
Ent638_3681	COG0312	modulator of DNA gyrase
Ent638_3682	COG3164	Protein of unknown function
Ent638_3683	COG1530	ribonuclease E activity
Ent638_3685	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
Ent638_3686	COG1792	Involved in formation and maintenance of cell shape
Ent638_3687	COG1077	Cell shape determining protein MreB Mrl
Ent638_3688	COG2200	EAL domain
Ent638_3688	COG2199	diguanylate cyclase activity
Ent638_3689	COG0604	alcohol dehydrogenase
Ent638_3691	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
Ent638_3692	COG0757	Catalyzes a trans-dehydration via an enolate intermediate
Ent638_3693	COG0511	ligase activity, forming carbon-carbon bonds
Ent638_3694	COG0439	Biotin carboxylase
Ent638_3695	COG3924	membrane
Ent638_3696	COG4145	pantothenate transmembrane transporter activity
Ent638_3697	COG2264	protein methyltransferase activity
Ent638_3699	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
Ent638_3700	COG2901	Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters
Ent638_3703	COG1309	transcriptional regulator
Ent638_3704	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
Ent638_3705	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
Ent638_3707	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
Ent638_3708	COG4597	amino acid ABC transporter
Ent638_3709	COG0765	amino acid transport
Ent638_3710	COG1126	abc transporter atp-binding protein
Ent638_3711	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
Ent638_3713	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
Ent638_3714	COG0009	L-threonylcarbamoyladenylate synthase
Ent638_3715	COG0551	DNA topoisomerase type I activity
Ent638_3716	COG2922	Belongs to the Smg family
Ent638_3717	COG0758	DNA mediated transformation
Ent638_3718	COG0242	peptide deformylase activity
Ent638_3719	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
Ent638_3720	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
Ent638_3720	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
Ent638_3721	COG0569	domain protein
Ent638_3722	COG1970	mechanosensitive ion channel activity
Ent638_3723	COG3036	rescue of stalled ribosome
Ent638_3724	COG0789	Transcriptional regulator
Ent638_3725	COG0203	ribosomal protein L17
Ent638_3726	COG0202	RNA polymerase activity
Ent638_3727	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
Ent638_3728	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
Ent638_3730	COG0257	Belongs to the bacterial ribosomal protein bL36 family
Ent638_3731	COG0201	protein transport
Ent638_3732	COG0200	Binds to the 23S rRNA
Ent638_3733	COG1841	ribosomal large subunit assembly
Ent638_3734	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
Ent638_3735	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
Ent638_3736	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
Ent638_3737	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
Ent638_3738	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
Ent638_3739	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
Ent638_3740	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
Ent638_3741	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
Ent638_3742	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
Ent638_3743	COG0255	Belongs to the universal ribosomal protein uL29 family
Ent638_3744	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
Ent638_3746	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
Ent638_3748	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
Ent638_3750	COG0088	Forms part of the polypeptide exit tunnel
Ent638_3751	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
Ent638_3752	COG0051	transcription antitermination factor activity, RNA binding
Ent638_3755	COG2906	2 iron, 2 sulfur cluster binding
Ent638_3756	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
Ent638_3757	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
Ent638_3758	COG0049	tRNA binding
Ent638_3760	COG2168	tRNA wobble position uridine thiolation
Ent638_3761	COG2923	Belongs to the DsrF TusC family
Ent638_3762	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
Ent638_3763	COG2964	Protein conserved in bacteria
Ent638_3764	COG0545	Peptidyl-prolyl cis-trans isomerase
Ent638_3765	COG2900	Belongs to the SlyX family
Ent638_3766	COG1047	Peptidyl-prolyl cis-trans
Ent638_3767	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
Ent638_3768	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
Ent638_3768	COG0475	glutathione-regulated potassium exporter activity
Ent638_3769	COG2249	NAD(P)H dehydrogenase (quinone) activity
Ent638_3770	COG0488	(ABC) transporter
Ent638_3772	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
Ent638_3774	COG0679	Auxin Efflux Carrier
Ent638_3780	COG0429	hydrolase of the alpha beta-hydrolase fold
Ent638_3781	COG3089	Belongs to the UPF0270 family
Ent638_3782	COG3954	Phosphoribulokinase
Ent638_3783	COG1765	OsmC-like protein
Ent638_3785	COG1289	transmembrane transporter activity
Ent638_3787	COG0512	Glutamine amidotransferase of anthranilate synthase
Ent638_3788	COG2184	nucleotidyltransferase activity
Ent638_3791	COG0738	Major facilitator superfamily
Ent638_3792	COG0402	S-adenosylhomocysteine deaminase activity
Ent638_3793	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
Ent638_3794	COG2146	nitrite reductase [NAD(P)H] activity
Ent638_3796	COG1648	precorrin-2 dehydrogenase activity
Ent638_3796	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
Ent638_3799	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
Ent638_3800	COG0338	D12 class N6 adenine-specific DNA methyltransferase
Ent638_3801	COG3266	domain, Protein
Ent638_3802	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
Ent638_3803	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
Ent638_3804	COG4796	Type ii and iii secretion system protein
Ent638_3808	COG4972	Pilus assembly protein
Ent638_3809	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
Ent638_3810	COG0494	nUDIX hydrolase
Ent638_3812	COG1011	Hydrolase
Ent638_3813	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
Ent638_3814	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
Ent638_3815	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
Ent638_3816	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
Ent638_3818	COG0745	RESPONSE REGULATOR receiver
Ent638_3819	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
Ent638_3820	COG2183	response to ionizing radiation
Ent638_3821	COG1918	ferrous iron import across plasma membrane
Ent638_3826	COG1040	competence protein
Ent638_3827	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
Ent638_3827	COG0316	Belongs to the HesB IscA family
Ent638_3828	COG2610	gluconate transmembrane transporter activity
Ent638_3829	COG1640	4-alpha-glucanotransferase
Ent638_3830	COG0058	SHG alpha-glucan phosphorylase activity
Ent638_3831	COG2909	trisaccharide binding
Ent638_3832	COG1349	DNA-binding transcription factor activity
Ent638_3833	COG0705	Rhomboid family
Ent638_3834	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
Ent638_3835	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
Ent638_3836	COG0058	SHG alpha-glucan phosphorylase activity
Ent638_3837	COG0297	glycogen (starch) synthase activity
Ent638_3838	COG0448	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans
Ent638_3839	COG1523	belongs to the glycosyl hydrolase 13 family
Ent638_3840	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
Ent638_3841	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
Ent638_3842	COG2095	MarC family integral membrane protein
Ent638_3844	COG2610	gluconate transmembrane transporter activity
Ent638_3845	COG3265	gluconokinase activity
Ent638_3846	COG1609	Transcriptional regulator
Ent638_3847	COG1741	Belongs to the pirin family
Ent638_3848	COG0673	inositol 2-dehydrogenase activity
Ent638_3849	COG1247	-acetyltransferase
Ent638_3850	COG0405	Gamma-glutamyltransferase
Ent638_3852	COG0584	glycerophosphoryl diester phosphodiesterase
Ent638_3856	COG1653	transport
Ent638_3857	COG0410	ABC transporter
Ent638_3858	COG0411	ABC transporter
Ent638_3859	COG4177	L-phenylalanine transmembrane transporter activity
Ent638_3860	COG0559	Belongs to the binding-protein-dependent transport system permease family
Ent638_3861	COG0683	leucine binding
Ent638_3863	COG0683	leucine binding
Ent638_3864	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
Ent638_3865	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
Ent638_3866	COG2177	Part of the ABC transporter FtsEX involved in
Ent638_3867	COG2884	Cell division ATP-binding protein ftsE
Ent638_3868	COG0552	protein localization to endoplasmic reticulum
Ent638_3869	COG0742	ribosomal rna small subunit methyltransferase
Ent638_3870	COG3776	membrane
Ent638_3872	COG3714	YhhN family
Ent638_3876	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
Ent638_3877	COG0425	Belongs to the sulfur carrier protein TusA family
Ent638_3878	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
Ent638_3880	COG0477	Major facilitator Superfamily
Ent638_3881	COG0628	permease
Ent638_3887	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
Ent638_3889	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
Ent638_3889	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
Ent638_3890	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
Ent638_3891	COG1216	Glycosyl transferase, family 2
Ent638_3896	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
Ent638_3898	COG1028	Short-chain dehydrogenase reductase Sdr
Ent638_3899	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
Ent638_3901	COG1028	Short-chain dehydrogenase reductase Sdr
Ent638_3902	COG0791	NLP P60 protein
Ent638_3903	COG0560	Phosphoserine phosphatase
Ent638_3906	COG2081	HI0933 family
Ent638_3907	COG0306	phosphate transporter
Ent638_3909	COG0589	response to stress
Ent638_3910	COG0742	ribosomal rna small subunit methyltransferase
Ent638_3912	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
Ent638_3913	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
Ent638_3917	COG1028	Short-chain dehydrogenase reductase Sdr
Ent638_3918	COG0583	DNA-binding transcription factor activity
Ent638_3919	COG1295	ribonuclease BN
Ent638_3920	COG0477	Major facilitator Superfamily
Ent638_3921	COG2982	Protein involved in outer membrane biogenesis
Ent638_3922	COG2200	EAL domain
Ent638_3923	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
Ent638_3924	COG0612	Peptidase, M16
Ent638_3925	COG1301	dicarboxylic acid transport
Ent638_3926	COG2200	EAL domain
Ent638_3926	COG2199	diguanylate cyclase activity
Ent638_3927	COG3118	belongs to the thioredoxin family
Ent638_3927	COG0457	Tetratricopeptide repeat
Ent638_3928	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
Ent638_3929	COG1215	transferase activity, transferring glycosyl groups
Ent638_3935	COG2194	sulfuric ester hydrolase activity
Ent638_3944	COG0812	UDP-N-acetylmuramate dehydrogenase activity
Ent638_3947	COG1739	Uncharacterized protein family UPF0029
Ent638_3948	COG0006	proline dipeptidase activity
Ent638_3949	COG1250	3-hydroxyacyl-CoA dehydrogenase
Ent638_3949	COG1024	Enoyl-CoA hydratase
Ent638_3950	COG0183	Belongs to the thiolase family
Ent638_3952	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
Ent638_3954	COG0084	hydrolase, TatD family'
Ent638_3955	COG0805	protein transport
Ent638_3957	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
Ent638_3958	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
Ent638_3959	COG3165	ubiquinone biosynthetic process from chorismate
Ent638_3960	COG2226	methyltransferase
Ent638_3961	COG1322	Protein conserved in bacteria
Ent638_3962	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
Ent638_3963	COG0412	Dienelactone hydrolase
Ent638_3964	COG2190	(PTS) system
Ent638_3964	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
Ent638_3964	COG1263	PTS System
Ent638_3965	COG2723	6-phospho-beta-galactosidase activity
Ent638_3966	COG3711	transcriptional antiterminator
Ent638_3967	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
Ent638_3968	COG0583	DNA-binding transcription factor activity
Ent638_3970	COG0561	phosphatase activity
Ent638_3971	COG2267	carboxylic ester hydrolase activity
Ent638_3972	COG1280	lysine exporter protein (LysE YggA)
Ent638_3973	COG1280	lysine exporter protein (LysE YggA)
Ent638_3975	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
Ent638_3976	COG2050	protein possibly involved in aromatic compounds catabolism
Ent638_3980	COG1011	Hydrolase
Ent638_3983	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
Ent638_3984	COG5567	small periplasmic lipoprotein
Ent638_3985	COG1965	Belongs to the frataxin family
Ent638_3986	COG3072	Adenylate cyclase
Ent638_3987	COG0181	hydroxymethylbilane synthase activity
Ent638_3989	COG2959	enzyme of heme biosynthesis
Ent638_3990	COG3071	HemY protein
Ent638_3992	COG1113	amino acid transport
Ent638_3993	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
Ent638_3996	COG2244	polysaccharide biosynthetic process
Ent638_3997	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
Ent638_3998	COG0456	acetyltransferase
Ent638_3999	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
Ent638_4000	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
Ent638_4002	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
Ent638_4003	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
Ent638_4004	COG3118	belongs to the thioredoxin family
Ent638_4005	COG0513	Belongs to the DEAD box helicase family
Ent638_4006	COG0248	Ppx GppA phosphatase
Ent638_4008	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
Ent638_4009	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
Ent638_4010	COG0583	DNA-binding transcription factor activity
Ent638_4011	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
Ent638_4012	COG0129	dihydroxy-acid dehydratase activity
Ent638_4013	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
Ent638_4014	COG3978	acetolactate synthase activity
Ent638_4017	COG3085	chromosome segregation
Ent638_4020	COG4206	TonB-dependent receptor
Ent638_4021	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
Ent638_4023	COG1309	transcriptional regulator
Ent638_4024	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
Ent638_4025	COG0583	DNA-binding transcription factor activity
Ent638_4026	COG0165	Argininosuccinate lyase
Ent638_4027	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
Ent638_4028	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
Ent638_4029	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
Ent638_4030	COG2352	Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle
Ent638_4031	COG0371	Dehydrogenase
Ent638_4032	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
Ent638_4033	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
Ent638_4034	COG0527	aspartate kinase activity
Ent638_4034	COG0460	homoserine dehydrogenase
Ent638_4035	COG0626	cystathionine gamma-synthase activity
Ent638_4036	COG3060	This regulatory protein, when combined with SAM (S- adenosylmethionine) represses the expression of the methionine regulon and of enzymes involved in SAM synthesis
Ent638_4037	COG0254	rRNA binding
Ent638_4038	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
Ent638_4039	COG1609	Transcriptional regulator
Ent638_4040	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
Ent638_4041	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
Ent638_4042	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
Ent638_4043	COG1575	Belongs to the MenA family. Type 1 subfamily
Ent638_4044	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
Ent638_4045	COG3074	FtsZ-dependent cytokinesis
Ent638_4046	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
Ent638_4047	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
Ent638_4048	COG1494	fructose-1,6-bisphosphatase
Ent638_4050	COG3152	Membrane
Ent638_4052	COG0149	triose-phosphate isomerase activity
Ent638_4054	COG2134	cdp-diacylglycerol pyrophosphatase
Ent638_4056	COG0205	6-phosphofructokinase activity
Ent638_4059	COG3678	ATP-independent chaperone mediated protein folding
Ent638_4060	COG0745	RESPONSE REGULATOR receiver
Ent638_4061	COG2205	protein histidine kinase activity
Ent638_4062	COG2258	MOSC domain
Ent638_4063	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
Ent638_4065	COG4977	sequence-specific DNA binding
Ent638_4065	COG1917	Cupin 2, conserved barrel domain protein
Ent638_4066	COG4977	sequence-specific DNA binding
Ent638_4067	COG1070	Carbohydrate kinase
Ent638_4068	COG4806	L-rhamnose isomerase
Ent638_4069	COG0235	Class ii aldolase
Ent638_4070	COG1879	ABC-type sugar transport system periplasmic component
Ent638_4071	COG1129	ABC transporter
Ent638_4072	COG1172	Belongs to the binding-protein-dependent transport system permease family
Ent638_4074	COG1454	alcohol dehydrogenase
Ent638_4075	COG3254	rhamnose metabolic process
Ent638_4076	COG2211	Major facilitator Superfamily
Ent638_4080	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
Ent638_4084	COG3383	formate dehydrogenase (NAD+) activity
Ent638_4084	COG0243	molybdopterin cofactor binding
Ent638_4085	COG3383	formate dehydrogenase (NAD+) activity
Ent638_4085	COG0243	molybdopterin cofactor binding
Ent638_4086	COG0437	4 iron, 4 sulfur cluster binding
Ent638_4087	COG2864	formate dehydrogenase
Ent638_4088	COG3058	Necessary for formate dehydrogenase activity
Ent638_4090	COG0456	acetyltransferase
Ent638_4091	COG1490	D-aminoacyl-tRNA deacylase activity
Ent638_4092	COG1295	ribonuclease BN
Ent638_4093	COG1011	Hydrolase
Ent638_4096	COG0174	glutamine synthetase
Ent638_4097	COG3852	Histidine kinase
Ent638_4098	COG2204	response regulator
Ent638_4099	COG0635	Involved in the biosynthesis of porphyrin-containing compound
Ent638_4100	COG3078	GTPase activator activity
Ent638_4101	COG0218	Necessary for normal cell division and for the maintenance of normal septation
Ent638_4105	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
Ent638_4106	COG3084	Protein conserved in bacteria
Ent638_4107	COG0746	molybdenum cofactor guanylyltransferase activity
Ent638_4108	COG1763	Mo-molybdopterin cofactor biosynthetic process
Ent638_4109	COG2186	Transcriptional regulator
Ent638_4110	COG0477	Major facilitator Superfamily
Ent638_4111	COG1609	Transcriptional regulator
Ent638_4112	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
Ent638_4113	COG1879	ABC-type sugar transport system periplasmic component
Ent638_4114	COG1172	Belongs to the binding-protein-dependent transport system permease family
Ent638_4116	COG1869	D-ribose catabolic process
Ent638_4117	COG3158	transport of potassium into the cell
Ent638_4119	COG2425	protein containing a von Willebrand factor type A (vWA) domain
Ent638_4120	COG2502	aspartate--ammonia ligase
Ent638_4121	COG1522	sequence-specific DNA binding
Ent638_4122	COG0716	FMN binding
Ent638_4123	COG0445	tRNA wobble uridine modification
Ent638_4124	COG0357	Ribosomal RNA small subunit methyltransferase G
Ent638_4125	COG3312	ion transport
Ent638_4126	COG0356	it plays a direct role in the translocation of protons across the membrane
Ent638_4128	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
Ent638_4129	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
Ent638_4130	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
Ent638_4131	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
Ent638_4132	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
Ent638_4133	COG0355	proton-transporting ATP synthase activity, rotational mechanism
Ent638_4135	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
Ent638_4137	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
Ent638_4138	COG0573	inorganic phosphate transmembrane transporter activity
Ent638_4139	COG0581	inorganic phosphate transmembrane transporter activity
Ent638_4141	COG0704	Plays a role in the regulation of phosphate uptake
Ent638_4142	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
Ent638_4143	COG2252	PERMEase
Ent638_4144	COG0431	NADPH-dependent FMN reductase
Ent638_4145	COG2091	lysine biosynthetic process via aminoadipic acid
Ent638_4148	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
Ent638_4149	COG0706	membrane insertase activity
Ent638_4150	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
Ent638_4152	COG0230	Belongs to the bacterial ribosomal protein bL34 family
Ent638_4212	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
Ent638_4219	COG2207	Transcriptional regulator
Ent638_4220	COG1902	pentaerythritol trinitrate reductase activity
Ent638_4221	COG0667	Aldo Keto reductase
Ent638_4226	COG3077	Addiction module antitoxin, RelB DinJ family
Ent638_4227	COG2026	Addiction module toxin, RelE StbE family
Ent638_4228	COG2026	Addiction module toxin, RelE StbE family
Ent638_4233	COG1262	PFAM Formylglycine-generating sulfatase enzyme
Ent638_4235	COG1136	(ABC) transporter
Ent638_4241	COG2304	oxidoreductase activity
Ent638_4244	COG0589	response to stress
Ent638_4245	COG3459	Glycosyltransferase 36 associated
Ent638_4247	COG3685	Protein conserved in bacteria
Ent638_4250	COG1192	Involved in chromosome partitioning
Ent638_4251	COG1475	DNA binding
Ent638_4254	COG0431	NADPH-dependent FMN reductase
Ent638_4255	COG0640	Transcriptional regulator
Ent638_4257	COG1393	Belongs to the ArsC family
Ent638_4261	COG0477	Major facilitator Superfamily
Ent638_4262	COG3077	Addiction module antitoxin, RelB DinJ family
Ent638_4263	COG2026	Addiction module toxin, RelE StbE family
Ent638_4264	COG2026	Addiction module toxin, RelE StbE family
Ent638_4265	COG0457	Tetratricopeptide repeat
Ent638_4268	COG3077	Addiction module antitoxin, RelB DinJ family
Ent638_4273	COG1475	DNA binding
Ent638_4321	COG2963	transposase activity
Ent638_4322	COG1192	Involved in chromosome partitioning