locus-tag	class	description
JCP76_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
JCP76_00010	COG0592	DNA-directed DNA polymerase activity
JCP76_00015	COG2501	S4 domain
JCP76_00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
JCP76_00025	COG0187	DNA topoisomerase II activity
JCP76_00035	COG0360	Binds together with S18 to 16S ribosomal RNA
JCP76_00040	COG0629	single-stranded DNA binding
JCP76_00045	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
JCP76_00055	COG0359	binds to the 23S rRNA
JCP76_00060	COG0305	Participates in initiation and elongation during chromosome replication
JCP76_00065	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
JCP76_00075	COG0488	(ABC) transporter
JCP76_00085	COG0028	Belongs to the TPP enzyme family
JCP76_00130	COG3328	transposase activity
JCP76_00160	COG2723	6-phospho-beta-galactosidase activity
JCP76_00170	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
JCP76_00170	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
JCP76_00180	COG3328	transposase activity
JCP76_00210	COG1674	ftsk spoiiie
JCP76_00215	COG2946	Replication initiation factor
JCP76_00260	COG0741	lytic transglycosylase activity
JCP76_00260	COG0791	NLP P60 protein
JCP76_00305	COG0582	viral genome integration into host DNA
JCP76_00310	COG0518	GMP synthase (glutamine-hydrolyzing) activity
JCP76_00310	COG0519	Catalyzes the synthesis of GMP from XMP
JCP76_00315	COG1072	(Pantothenic acid kinase))
JCP76_00320	COG2813	Specifically methylates the guanine in position
JCP76_00325	COG1609	Transcriptional regulator
JCP76_00330	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
JCP76_00335	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
JCP76_00340	COG0295	cytidine deaminase activity
JCP76_00345	COG1744	ABC transporter substrate-binding protein PnrA-like
JCP76_00350	COG3845	ABC transporter
JCP76_00355	COG4603	Belongs to the binding-protein-dependent transport system permease family
JCP76_00360	COG1079	Belongs to the binding-protein-dependent transport system permease family
JCP76_00365	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
JCP76_00375	COG0813	purine-nucleoside phosphorylase activity
JCP76_00380	COG0588	phosphoglycerate mutase activity
JCP76_00390	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
JCP76_00395	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
JCP76_00400	COG0049	tRNA binding
JCP76_00405	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
JCP76_00410	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
JCP76_00415	COG0051	transcription antitermination factor activity, RNA binding
JCP76_00420	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
JCP76_00425	COG0088	Forms part of the polypeptide exit tunnel
JCP76_00430	COG0089	rRNA binding
JCP76_00435	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
JCP76_00445	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
JCP76_00450	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
JCP76_00455	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
JCP76_00460	COG0255	Belongs to the universal ribosomal protein uL29 family
JCP76_00465	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
JCP76_00470	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
JCP76_00475	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
JCP76_00480	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
JCP76_00485	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
JCP76_00490	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
JCP76_00495	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
JCP76_00500	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
JCP76_00505	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
JCP76_00510	COG1841	ribosomal large subunit assembly
JCP76_00515	COG0200	Binds to the 23S rRNA
JCP76_00520	COG0201	protein transport
JCP76_00525	COG0563	adenylate kinase activity
JCP76_00530	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
JCP76_00535	COG0257	Belongs to the bacterial ribosomal protein bL36 family
JCP76_00540	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
JCP76_00545	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
JCP76_00550	COG0202	RNA polymerase activity
JCP76_00555	COG0203	ribosomal protein L17
JCP76_00560	COG1122	ATPase activity
JCP76_00565	COG1122	ATPase activity
JCP76_00575	COG0101	tRNA pseudouridine synthase activity
JCP76_00585	COG0227	Belongs to the bacterial ribosomal protein bL28 family
JCP76_00595	COG1461	Dihydroxyacetone kinase
JCP76_00600	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
JCP76_00605	COG0416	fatty acid biosynthetic process
JCP76_00610	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
JCP76_00620	COG4608	Belongs to the ABC transporter superfamily
JCP76_00625	COG0601	transmembrane transport
JCP76_00640	COG0571	ribonuclease III activity
JCP76_00645	COG1196	nuclear chromosome segregation
JCP76_00650	COG0561	phosphatase activity
JCP76_00655	COG0552	protein localization to endoplasmic reticulum
JCP76_00660	COG1181	Belongs to the D-alanine--D-alanine ligase family
JCP76_00660	COG2918	glutathione biosynthetic process
JCP76_00670	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
JCP76_00675	COG4605	iron ion homeostasis
JCP76_00680	COG4604	ABC transporter, ATP-binding protein
JCP76_00685	COG4607	ABC-type enterochelin transport system periplasmic component
JCP76_00710	COG4932	domain protein
JCP76_00710	COG4886	Leucine-rich repeat (LRR) protein
JCP76_00725	COG3328	transposase activity
JCP76_00745	COG1380	Effector of murein hydrolase LrgA
JCP76_00750	COG1346	cytolysis
JCP76_00775	COG1028	Short-chain dehydrogenase reductase Sdr
JCP76_00785	COG1268	BioY protein
JCP76_00790	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
JCP76_00805	COG0561	phosphatase activity
JCP76_00810	COG1692	metallophosphoesterase
JCP76_00820	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
JCP76_00830	COG0424	maF-like protein
JCP76_00835	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
JCP76_00835	COG1263	PTS System
JCP76_00840	COG2188	Transcriptional regulator
JCP76_00850	COG0632	four-way junction helicase activity
JCP76_00855	COG2255	four-way junction helicase activity
JCP76_00865	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
JCP76_00875	COG3328	transposase activity
JCP76_00880	COG1114	Component of the transport system for branched-chain amino acids
JCP76_00890	COG1113	amino acid transport
JCP76_00895	COG1126	abc transporter atp-binding protein
JCP76_00900	COG0765	amino acid transport
JCP76_00910	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
JCP76_00915	COG0110	maltose O-acetyltransferase activity
JCP76_00920	COG1827	regulation of RNA biosynthetic process
JCP76_00925	COG0242	peptide deformylase activity
JCP76_00930	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
JCP76_00935	COG1185	polyribonucleotide nucleotidyltransferase activity
JCP76_00945	COG3158	transport of potassium into the cell
JCP76_00950	COG1253	flavin adenine dinucleotide binding
JCP76_00955	COG0534	Mate efflux family protein
JCP76_00965	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
JCP76_00970	COG1187	pseudouridine synthase activity
JCP76_00975	COG1011	Hydrolase
JCP76_00980	COG0572	uridine kinase
JCP76_01005	COG1671	Belongs to the UPF0178 family
JCP76_01015	COG1181	Belongs to the D-alanine--D-alanine ligase family
JCP76_01020	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
JCP76_01030	COG0736	holo-[acyl-carrier-protein] synthase activity
JCP76_01035	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
JCP76_01040	COG2337	Toxic component of a toxin-antitoxin (TA) module
JCP76_01045	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
JCP76_01050	COG3321	synthase
JCP76_01050	COG0604	alcohol dehydrogenase
JCP76_01060	COG0531	amino acid
JCP76_01085	COG1174	glycine betaine transport
JCP76_01105	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
JCP76_01120	COG0343	queuine tRNA-ribosyltransferase activity
JCP76_01125	COG1862	Preprotein translocase
JCP76_01130	COG1012	belongs to the aldehyde dehydrogenase family
JCP76_01130	COG1454	alcohol dehydrogenase
JCP76_01140	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
JCP76_01170	COG2207	Transcriptional regulator
JCP76_01170	COG1917	Cupin 2, conserved barrel domain protein
JCP76_01175	COG1070	Carbohydrate kinase
JCP76_01180	COG4806	L-rhamnose isomerase
JCP76_01185	COG0235	Class ii aldolase
JCP76_01190	COG3254	rhamnose metabolic process
JCP76_01195	COG1454	alcohol dehydrogenase
JCP76_01200	COG1414	Transcriptional regulator
JCP76_01205	COG0800	Aldolase
JCP76_01215	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
JCP76_01220	COG1028	Short-chain dehydrogenase reductase Sdr
JCP76_01225	COG1304	FMN binding
JCP76_01240	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
JCP76_01245	COG1428	Deoxynucleoside kinase
JCP76_01265	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
JCP76_01270	COG0291	Belongs to the bacterial ribosomal protein bL35 family
JCP76_01275	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
JCP76_01305	COG0824	Thioesterase
JCP76_01310	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
JCP76_01330	COG1363	Peptidase, m42
JCP76_01335	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
JCP76_01340	COG0589	response to stress
JCP76_01345	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
JCP76_01350	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
JCP76_01355	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
JCP76_01360	COG4807	Protein conserved in bacteria
JCP76_01370	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
JCP76_01385	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
JCP76_01450	COG1368	sulfuric ester hydrolase activity
JCP76_01460	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
JCP76_01470	COG0101	tRNA pseudouridine synthase activity
JCP76_01485	COG3328	transposase activity
JCP76_01505	COG0667	Aldo Keto reductase
JCP76_01510	COG2186	Transcriptional regulator
JCP76_01515	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
JCP76_01520	COG2723	6-phospho-beta-galactosidase activity
JCP76_01530	COG1447	Phosphotransferase system cellobiose-specific component IIA
JCP76_01550	COG1063	alcohol dehydrogenase
JCP76_01560	COG4716	Myosin-crossreactive antigen
JCP76_01600	COG1113	amino acid transport
JCP76_01625	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
JCP76_01635	COG3052	prosthetic group binding
JCP76_01695	COG1051	belongs to the nudix hydrolase family
JCP76_01700	COG1846	Transcriptional regulator
JCP76_01725	COG2252	PERMEase
JCP76_01730	COG0366	Alpha amylase catalytic
JCP76_01735	COG2723	6-phospho-beta-galactosidase activity
JCP76_01745	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
JCP76_01745	COG2190	(PTS) system
JCP76_01745	COG1263	PTS System
JCP76_01750	COG2723	6-phospho-beta-galactosidase activity
JCP76_01760	COG1902	pentaerythritol trinitrate reductase activity
JCP76_01770	COG0446	pyridine nucleotide-disulphide oxidoreductase
JCP76_01780	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
JCP76_01785	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
JCP76_01790	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
JCP76_01800	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
JCP76_01810	COG1937	Protein conserved in bacteria
JCP76_01815	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
JCP76_01820	COG0446	pyridine nucleotide-disulphide oxidoreductase
JCP76_01825	COG3973	AAA domain
JCP76_01850	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
JCP76_01855	COG2376	Dihydroxyacetone kinase
JCP76_01860	COG1461	Dihydroxyacetone kinase
JCP76_01870	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
JCP76_01880	COG1131	(ABC) transporter
JCP76_01885	COG1309	transcriptional regulator
JCP76_01905	COG0531	amino acid
JCP76_01915	COG1609	Transcriptional regulator
JCP76_01925	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
JCP76_01935	COG1263	PTS System
JCP76_01935	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
JCP76_01935	COG2190	(PTS) system
JCP76_01960	COG3479	Phenolic acid decarboxylase
JCP76_01965	COG1695	Transcriptional regulator
JCP76_01975	COG2814	Major facilitator Superfamily
JCP76_01995	COG0163	prenyltransferase activity
JCP76_02000	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
JCP76_02010	COG0577	efflux transmembrane transporter activity
JCP76_02010	COG1136	(ABC) transporter
JCP76_02030	COG1811	Na channel or pump
JCP76_02065	COG1136	(ABC) transporter
JCP76_02080	COG1705	Flagellar rod assembly protein muramidase FlgJ
JCP76_02080	COG3942	CHAP domain
JCP76_02085	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
JCP76_02085	COG2190	(PTS) system
JCP76_02085	COG1263	PTS System
JCP76_02090	COG1869	D-ribose catabolic process
JCP76_02100	COG1609	Transcriptional regulator
JCP76_02120	COG0366	Alpha amylase catalytic
JCP76_02125	COG0628	permease
JCP76_02130	COG3443	Belongs to the bacterial solute-binding protein 9 family
JCP76_02130	COG0803	Belongs to the bacterial solute-binding protein 9 family
JCP76_02155	COG1428	Deoxynucleoside kinase
JCP76_02165	COG0210	DNA helicase
JCP76_02175	COG1393	Belongs to the ArsC family
JCP76_02180	COG1393	Belongs to the ArsC family
JCP76_02185	COG2801	Transposase and inactivated derivatives
JCP76_02190	COG2963	transposase activity
JCP76_02210	COG0386	Belongs to the glutathione peroxidase family
JCP76_02215	COG1854	S-ribosylhomocysteine lyase activity
JCP76_02220	COG0626	cystathionine gamma-synthase activity
JCP76_02230	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
JCP76_02235	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
JCP76_02245	COG0019	diaminopimelate decarboxylase activity
JCP76_02250	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
JCP76_02260	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
JCP76_02265	COG2171	N-acyltransferase activity
JCP76_02270	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
JCP76_02275	COG0527	aspartate kinase activity
JCP76_02280	COG1473	amidohydrolase
JCP76_02285	COG0436	Aminotransferase
JCP76_02290	COG0446	pyridine nucleotide-disulphide oxidoreductase
JCP76_02310	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
JCP76_02315	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
JCP76_02330	COG2207	Transcriptional regulator
JCP76_02335	COG2249	NAD(P)H dehydrogenase (quinone) activity
JCP76_02350	COG1113	amino acid transport
JCP76_02355	COG1121	(ABC) transporter
JCP76_02360	COG1108	ABC-type Mn2 Zn2 transport systems permease components
JCP76_02375	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
JCP76_02380	COG1652	LysM domain
JCP76_02380	COG2823	Periplasmic or secreted lipoprotein
JCP76_02390	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
JCP76_02395	COG0477	Major facilitator Superfamily
JCP76_02405	COG1438	arginine binding
JCP76_02420	COG1764	response to oxidative stress
JCP76_02425	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
JCP76_02430	COG1335	isochorismatase
JCP76_02445	COG2135	peptidase activity
JCP76_02480	COG3546	catalase activity
JCP76_02490	COG1175	transmembrane transport
JCP76_02495	COG0395	ABC-type sugar transport system, permease component
JCP76_02535	COG0745	RESPONSE REGULATOR receiver
JCP76_02540	COG2205	protein histidine kinase activity
JCP76_02545	COG4975	Glucose uptake
JCP76_02550	COG0531	amino acid
JCP76_02555	COG3853	Toxic anion resistance protein (TelA)
JCP76_02575	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
JCP76_02580	COG1335	isochorismatase
JCP76_02590	COG3590	peptidase
JCP76_02600	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
JCP76_02605	COG1104	cysteine desulfurase activity
JCP76_02625	COG0482	sulfurtransferase activity
JCP76_02635	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
JCP76_02640	COG2814	Major facilitator Superfamily
JCP76_02660	COG0463	Glycosyl transferase, family 2
JCP76_02665	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
JCP76_02670	COG2855	membrane
JCP76_02680	COG0583	DNA-binding transcription factor activity
JCP76_02685	COG0772	Belongs to the SEDS family
JCP76_02690	COG1393	Belongs to the ArsC family
JCP76_02695	COG0509	glycine decarboxylation via glycine cleavage system
JCP76_02700	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
JCP76_02705	COG2011	ABC-type metal ion transport system permease component
JCP76_02710	COG1464	Belongs to the NlpA lipoprotein family
JCP76_02720	COG0719	Fe-S assembly protein
JCP76_02725	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
JCP76_02735	COG0719	Fe-S assembly protein
JCP76_02815	COG1136	(ABC) transporter
JCP76_02815	COG0577	efflux transmembrane transporter activity
JCP76_02825	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
JCP76_02835	COG1597	lipid kinase activity
JCP76_02870	COG1733	regulation of RNA biosynthetic process
JCP76_02880	COG3764	Sortase (surface protein transpeptidase)
JCP76_02885	COG3711	transcriptional antiterminator
JCP76_02890	COG1263	PTS System
JCP76_02890	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
JCP76_02890	COG2190	(PTS) system
JCP76_02895	COG2723	6-phospho-beta-galactosidase activity
JCP76_02900	COG2188	Transcriptional regulator
JCP76_02910	COG1611	Belongs to the LOG family
JCP76_02920	COG1428	Deoxynucleoside kinase
JCP76_02940	COG2723	6-phospho-beta-galactosidase activity
JCP76_02950	COG1368	sulfuric ester hydrolase activity
JCP76_02960	COG0105	UTP biosynthetic process
JCP76_02965	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
JCP76_02970	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
JCP76_02975	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
JCP76_02980	COG2011	ABC-type metal ion transport system permease component
JCP76_02985	COG1464	Belongs to the NlpA lipoprotein family
JCP76_02995	COG1757	Na H antiporter
JCP76_03010	COG1113	amino acid transport
JCP76_03020	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
JCP76_03025	COG1929	Belongs to the glycerate kinase type-1 family
JCP76_03030	COG0488	(ABC) transporter
JCP76_03045	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
JCP76_03050	COG1263	PTS System
JCP76_03050	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
JCP76_03065	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
JCP76_03070	COG1131	(ABC) transporter
JCP76_03090	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
JCP76_03105	COG0346	lactoylglutathione lyase activity
JCP76_03130	COG0561	phosphatase activity
JCP76_03135	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
JCP76_03140	COG0280	phosphate acetyltransferase
JCP76_03145	COG0802	atpase or kinase
JCP76_03150	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
JCP76_03160	COG0708	Exodeoxyribonuclease III
JCP76_03170	COG0812	UDP-N-acetylmuramate dehydrogenase activity
JCP76_03195	COG1053	succinate dehydrogenase
JCP76_03205	COG0702	epimerase
JCP76_03210	COG4684	Psort location CytoplasmicMembrane, score
JCP76_03215	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
JCP76_03220	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
JCP76_03225	COG0604	alcohol dehydrogenase
JCP76_03235	COG3842	ATPase activity
JCP76_03240	COG1176	ABC-type spermidine putrescine transport system, permease component I
JCP76_03245	COG1177	transmembrane transport
JCP76_03250	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
JCP76_03255	COG3829	transcription factor binding
JCP76_03270	COG3715	PTS system
JCP76_03275	COG3716	PTS system mannose fructose sorbose family IID component
JCP76_03290	COG1940	carbohydrate kinase activity
JCP76_03320	COG0582	viral genome integration into host DNA
JCP76_03325	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
JCP76_03335	COG0789	Transcriptional regulator
JCP76_03345	COG0504	CTP synthase activity
JCP76_03355	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
JCP76_03360	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
JCP76_03365	COG0254	rRNA binding
JCP76_03385	COG1349	DNA-binding transcription factor activity
JCP76_03395	COG2814	Major facilitator Superfamily
JCP76_03405	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
JCP76_03425	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
JCP76_03430	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
JCP76_03435	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
JCP76_03440	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
JCP76_03445	COG3870	Protein conserved in bacteria
JCP76_03450	COG0470	DNA polymerase III
JCP76_03455	COG1774	PSP1 C-terminal conserved region
JCP76_03460	COG4467	Involved in initiation control of chromosome replication
JCP76_03475	COG0602	queuosine metabolic process
JCP76_03480	COG1328	CTP reductase activity
JCP76_03485	COG1136	(ABC) transporter
JCP76_03490	COG0577	efflux transmembrane transporter activity
JCP76_03500	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
JCP76_03505	COG1696	Membrane protein involved in D-alanine export
JCP76_03510	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
JCP76_03515	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
JCP76_03520	COG1363	Peptidase, m42
JCP76_03530	COG1234	tRNA 3'-trailer cleavage
JCP76_03535	COG0095	Lipoate-protein ligase
JCP76_03545	COG3328	transposase activity
JCP76_03565	COG3759	membrane
JCP76_03570	COG0659	secondary active sulfate transmembrane transporter activity
JCP76_03580	COG0261	This protein binds to 23S rRNA in the presence of protein L20
JCP76_03590	COG0211	Belongs to the bacterial ribosomal protein bL27 family
JCP76_03600	COG3933	PFAM sigma-54 factor interaction domain-containing protein
JCP76_03600	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
JCP76_03605	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
JCP76_03605	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
JCP76_03615	COG3715	PTS system
JCP76_03620	COG3716	PTS system mannose fructose sorbose family IID component
JCP76_03630	COG2261	transglycosylase associated protein
JCP76_03635	COG0006	proline dipeptidase activity
JCP76_03640	COG1302	Protein conserved in bacteria
JCP76_03645	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
JCP76_03650	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
JCP76_03655	COG1570	exodeoxyribonuclease VII activity
JCP76_03660	COG1722	exodeoxyribonuclease VII activity
JCP76_03670	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
JCP76_03675	COG1438	arginine binding
JCP76_03680	COG0497	DNA recombination
JCP76_03720	COG0768	penicillin binding
JCP76_03755	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
JCP76_03760	COG1799	cell septum assembly
JCP76_03770	COG2302	S4 RNA-binding domain
JCP76_03775	COG3599	regulation of cell shape
JCP76_03780	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
JCP76_03785	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
JCP76_03805	COG0673	inositol 2-dehydrogenase activity
JCP76_03810	COG0513	Belongs to the DEAD box helicase family
JCP76_03815	COG3933	PFAM sigma-54 factor interaction domain-containing protein
JCP76_03815	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
JCP76_03820	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
JCP76_03825	COG1447	Phosphotransferase system cellobiose-specific component IIA
JCP76_03830	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
JCP76_03875	COG2309	aminopeptidase activity
JCP76_03885	COG0716	FMN binding
JCP76_03890	COG0024	Methionine aminopeptidase
JCP76_03895	COG1295	ribonuclease BN
JCP76_03900	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
JCP76_03915	COG1215	transferase activity, transferring glycosyl groups
JCP76_03920	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
JCP76_03930	COG1088	dTDP-glucose 4,6-dehydratase activity
JCP76_03935	COG1091	dTDP-4-dehydrorhamnose reductase activity
JCP76_03950	COG1682	transport, permease protein
JCP76_03960	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
JCP76_03965	COG0438	transferase activity, transferring glycosyl groups
JCP76_03965	COG1216	Glycosyl transferase, family 2
JCP76_03980	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
JCP76_03985	COG0463	Glycosyl transferase, family 2
JCP76_03990	COG0438	transferase activity, transferring glycosyl groups
JCP76_04015	COG1086	Polysaccharide biosynthesis protein
JCP76_04020	COG2089	acid synthase
JCP76_04025	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
JCP76_04035	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
JCP76_04050	COG1083	cytidylyl-transferase
JCP76_04100	COG3328	transposase activity
JCP76_04105	COG4485	Bacterial membrane protein, YfhO
JCP76_04115	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
JCP76_04120	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
JCP76_04130	COG4585	Histidine kinase
JCP76_04140	COG0569	domain protein
JCP76_04170	COG2246	polysaccharide biosynthetic process
JCP76_04175	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
JCP76_04190	COG1316	TRANSCRIPTIONal
JCP76_04195	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
JCP76_04200	COG3397	chitin binding
JCP76_04205	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
JCP76_04210	COG2137	regulation of response to DNA damage stimulus
JCP76_04215	COG1194	a g-specific adenine glycosylase
JCP76_04220	COG3557	Belongs to the UPF0374 family
JCP76_04230	COG0628	permease
JCP76_04235	COG1253	flavin adenine dinucleotide binding
JCP76_04240	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
JCP76_04260	COG0542	response to heat
JCP76_04265	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
JCP76_04270	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
JCP76_04280	COG0438	transferase activity, transferring glycosyl groups
JCP76_04285	COG2084	Dehydrogenase
JCP76_04290	COG4703	Protein of unknown function (DUF1797)
JCP76_04295	COG0322	excinuclease ABC activity
JCP76_04300	COG1846	Transcriptional regulator
JCP76_04305	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
JCP76_04315	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
JCP76_04325	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
JCP76_04335	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
JCP76_04340	COG0439	Biotin carboxylase
JCP76_04345	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
JCP76_04350	COG0825	malonyl-CoA metabolic process
JCP76_04355	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
JCP76_04360	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
JCP76_04365	COG1534	Rna-binding protein
JCP76_04370	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
JCP76_04375	COG1713	HD superfamily hydrolase involved in NAD metabolism
JCP76_04380	COG0799	negative regulation of ribosome biogenesis
JCP76_04385	COG2226	methyltransferase
JCP76_04390	COG1323	Belongs to the UPF0348 family
JCP76_04395	COG0217	transcriptional regulatory protein
JCP76_04405	COG3973	AAA domain
JCP76_04410	COG2217	Heavy metal translocating P-type atpase
JCP76_04415	COG1942	4-Oxalocrotonate Tautomerase
JCP76_04420	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
JCP76_04430	COG1737	Transcriptional regulator
JCP76_04435	COG0768	penicillin binding
JCP76_04440	COG0561	phosphatase activity
JCP76_04445	COG2252	PERMEase
JCP76_04450	COG2814	Major facilitator Superfamily
JCP76_04460	COG0587	DNA-directed DNA polymerase activity
JCP76_04465	COG0205	6-phosphofructokinase activity
JCP76_04475	COG0583	DNA-binding transcription factor activity
JCP76_04485	COG0333	Belongs to the bacterial ribosomal protein bL32 family
JCP76_04495	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
JCP76_04500	COG0745	RESPONSE REGULATOR receiver
JCP76_04505	COG5002	protein histidine kinase activity
JCP76_04605	COG3711	transcriptional antiterminator
JCP76_04615	COG2190	(PTS) system
JCP76_04615	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
JCP76_04615	COG1263	PTS System
JCP76_04620	COG1486	melibiose metabolic process
JCP76_04625	COG1263	PTS System
JCP76_04625	COG2190	(PTS) system
JCP76_04625	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
JCP76_04630	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
JCP76_04650	COG1349	DNA-binding transcription factor activity
JCP76_04675	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
JCP76_04680	COG3623	hexulose-6-phosphate isomerase
JCP76_04690	COG0456	acetyltransferase
JCP76_04710	COG3711	transcriptional antiterminator
JCP76_04730	COG3775	system Galactitol-specific IIC component
JCP76_04745	COG0400	carboxylic ester hydrolase activity
JCP76_04750	COG0346	lactoylglutathione lyase activity
JCP76_04755	COG2188	Transcriptional regulator
JCP76_04760	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
JCP76_04765	COG2723	6-phospho-beta-galactosidase activity
JCP76_04770	COG0589	response to stress
JCP76_04785	COG1393	Belongs to the ArsC family
JCP76_04795	COG0351	phosphomethylpyrimidine kinase
JCP76_04800	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
JCP76_04805	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
JCP76_04815	COG3425	synthase
JCP76_04820	COG0183	Belongs to the thiolase family
JCP76_04835	COG0656	L-ascorbic acid biosynthetic process
JCP76_04855	COG0392	lysyltransferase activity
JCP76_04855	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
JCP76_04860	COG0596	Alpha beta hydrolase
JCP76_04865	COG0741	lytic transglycosylase activity
JCP76_04875	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
JCP76_04880	COG0358	DNA primase activity
JCP76_04885	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
JCP76_04895	COG2996	Protein conserved in bacteria
JCP76_04900	COG0735	belongs to the Fur family
JCP76_04910	COG4974	Belongs to the 'phage' integrase family
JCP76_04920	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
JCP76_04925	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
JCP76_04930	COG1187	pseudouridine synthase activity
JCP76_04935	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
JCP76_04940	COG1288	antiporter activity
JCP76_04945	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
JCP76_04965	COG0514	ATP-dependent DNA helicase (RecQ)
JCP76_04975	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
JCP76_04980	COG0539	negative regulation of cytoplasmic translation
JCP76_04985	COG1160	GTP binding
JCP76_04990	COG0776	regulation of translation
JCP76_05005	COG0457	Tetratricopeptide repeat
JCP76_05010	COG5582	Belongs to the UPF0302 family
JCP76_05015	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
JCP76_05020	COG1694	Mazg nucleotide pyrophosphohydrolase
JCP76_05025	COG0617	tRNA 3'-terminal CCA addition
JCP76_05045	COG0025	NhaP-type Na H and K H
JCP76_05050	COG0488	(ABC) transporter
JCP76_05055	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
JCP76_05065	COG1272	protein, Hemolysin III
JCP76_05070	COG1307	EDD domain protein, DegV family
JCP76_05075	COG2755	lipolytic protein G-D-S-L family
JCP76_05080	COG4698	Protein conserved in bacteria
JCP76_05090	COG4479	Belongs to the UPF0346 family
JCP76_05095	COG0681	Belongs to the peptidase S26 family
JCP76_05115	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
JCP76_05120	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
JCP76_05125	COG0758	DNA mediated transformation
JCP76_05130	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
JCP76_05135	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
JCP76_05140	COG4974	Belongs to the 'phage' integrase family
JCP76_05145	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
JCP76_05150	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
JCP76_05170	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
JCP76_05175	COG1832	CoA-binding protein
JCP76_05180	COG0187	DNA topoisomerase II activity
JCP76_05190	COG1882	Formate acetyltransferase
JCP76_05195	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
JCP76_05200	COG1227	inorganic diphosphatase activity
JCP76_05220	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
JCP76_05230	COG1073	alpha beta
JCP76_05235	COG1609	Transcriptional regulator
JCP76_05245	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
JCP76_05260	COG1732	Glycine betaine
JCP76_05275	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
JCP76_05285	COG1116	anion transmembrane transporter activity
JCP76_05290	COG0084	hydrolase, TatD family'
JCP76_05295	COG3942	CHAP domain
JCP76_05295	COG1388	LysM domain
JCP76_05315	COG3328	transposase activity
JCP76_05345	COG0436	Aminotransferase
JCP76_05365	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
JCP76_05370	COG4565	transcriptional regulatory protein
JCP76_05375	COG3290	protein histidine kinase activity
JCP76_05380	COG3290	protein histidine kinase activity
JCP76_05390	COG2268	Band 7 protein
JCP76_05405	COG0673	inositol 2-dehydrogenase activity
JCP76_05415	COG1876	peptidase activity
JCP76_05420	COG1705	Flagellar rod assembly protein muramidase FlgJ
JCP76_05420	COG1388	LysM domain
JCP76_05430	COG1653	transport
JCP76_05435	COG1175	transmembrane transport
JCP76_05440	COG0395	ABC-type sugar transport system, permease component
JCP76_05450	COG0673	inositol 2-dehydrogenase activity
JCP76_05455	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
JCP76_05460	COG2233	PERMEase
JCP76_05465	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
JCP76_05470	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
JCP76_05475	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
JCP76_05485	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
JCP76_05490	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
JCP76_05495	COG0047	phosphoribosylformylglycinamidine synthase activity
JCP76_05500	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
JCP76_05510	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
JCP76_05515	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
JCP76_05520	COG0138	bifunctional purine biosynthesis protein purh
JCP76_05525	COG0151	Belongs to the GarS family
JCP76_05530	COG4989	oxidoreductase activity
JCP76_05540	COG2972	Histidine kinase
JCP76_05550	COG4213	ABC transporter substrate-binding protein
JCP76_05560	COG4214	carbohydrate transport
JCP76_05565	COG0516	GMP reductase activity
JCP76_05570	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
JCP76_05580	COG0022	dehydrogenase e1 component
JCP76_05595	COG4476	Belongs to the UPF0223 family
JCP76_05600	COG0483	inositol monophosphate 1-phosphatase activity
JCP76_05605	COG1217	gtp-binding protein TYPA
JCP76_05610	COG0514	ATP-dependent DNA helicase (RecQ)
JCP76_05615	COG4838	Belongs to the UPF0358 family
JCP76_05620	COG0772	Belongs to the SEDS family
JCP76_05625	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
JCP76_05640	COG4471	UPF0298 protein
JCP76_05645	COG0742	ribosomal rna small subunit methyltransferase
JCP76_05650	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
JCP76_05655	COG3480	Lon protease (S16) C-terminal proteolytic domain
JCP76_05660	COG1555	photosystem II stabilization
JCP76_05660	COG1596	polysaccharide export
JCP76_05675	COG2131	deaminase
JCP76_05680	COG2333	competence protein COMEC
JCP76_05680	COG0658	competence protein
JCP76_05685	COG1466	dna polymerase III delta subunit
JCP76_05690	COG0268	Binds directly to 16S ribosomal RNA
JCP76_05700	COG2707	UPF0756 membrane protein
JCP76_05705	COG2217	Heavy metal translocating P-type atpase
JCP76_05710	COG1968	undecaprenyl-diphosphatase activity
JCP76_05730	COG1666	GTP binding
JCP76_05735	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
JCP76_05740	COG2151	metal-sulfur cluster biosynthetic enzyme
JCP76_05755	COG3942	CHAP domain
JCP76_05755	COG1388	LysM domain
JCP76_05810	COG4990	cell redox homeostasis
JCP76_05830	COG3104	oligopeptide transport
JCP76_05840	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
JCP76_05845	COG1074	ATP-dependent DNA helicase activity
JCP76_05850	COG1733	regulation of RNA biosynthetic process
JCP76_05855	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
JCP76_05860	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
JCP76_05860	COG0072	phenylalanine-tRNA ligase activity
JCP76_05870	COG1126	abc transporter atp-binding protein
JCP76_05875	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
JCP76_05880	COG0765	amino acid transport
JCP76_05885	COG0765	amino acid transport
JCP76_05890	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
JCP76_05895	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
JCP76_05905	COG0517	IMP dehydrogenase activity
JCP76_05910	COG0668	transmembrane transport
JCP76_05915	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
JCP76_05920	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
JCP76_05925	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
JCP76_05955	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
JCP76_05965	COG1234	tRNA 3'-trailer cleavage
JCP76_05970	COG0300	oxidoreductase activity
JCP76_05975	COG5416	Lipopolysaccharide assembly protein A domain
JCP76_05980	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
JCP76_05980	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
JCP76_05985	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
JCP76_05995	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
JCP76_06010	COG2826	transposase and inactivated derivatives, IS30 family
JCP76_06015	COG1705	Flagellar rod assembly protein muramidase FlgJ
JCP76_06015	COG1388	LysM domain
JCP76_06020	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
JCP76_06025	COG0735	belongs to the Fur family
JCP76_06030	COG0446	pyridine nucleotide-disulphide oxidoreductase
JCP76_06050	COG3935	DnaD domain protein
JCP76_06055	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
JCP76_06065	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
JCP76_06070	COG3331	DNA recombination
JCP76_06075	COG4474	Belongs to the UPF0398 family
JCP76_06080	COG3599	regulation of cell shape
JCP76_06090	COG0116	Belongs to the methyltransferase superfamily
JCP76_06095	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
JCP76_06100	COG1418	mRNA catabolic process
JCP76_06105	COG0156	8-amino-7-oxononanoate synthase activity
JCP76_06110	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
JCP76_06115	COG0531	amino acid
JCP76_06130	COG0513	Belongs to the DEAD box helicase family
JCP76_06135	COG2153	protein acetylation
JCP76_06140	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
JCP76_06145	COG4684	Psort location CytoplasmicMembrane, score
JCP76_06155	COG0328	RNA-DNA hybrid ribonuclease activity
JCP76_06165	COG1278	Cold shock
JCP76_06170	COG2759	Belongs to the formate--tetrahydrofolate ligase family
JCP76_06185	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
JCP76_06190	COG0564	pseudouridine synthase activity
JCP76_06200	COG2233	PERMEase
JCP76_06205	COG0540	Belongs to the ATCase OTCase family
JCP76_06210	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
JCP76_06215	COG0505	Belongs to the CarA family
JCP76_06220	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
JCP76_06225	COG0543	2 iron, 2 sulfur cluster binding
JCP76_06235	COG0284	orotidine-5'-phosphate decarboxylase activity
JCP76_06265	COG1293	RNA-binding protein homologous to eukaryotic snRNP
JCP76_06280	COG4120	Belongs to the binding-protein-dependent transport system permease family
JCP76_06290	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
JCP76_06325	COG0039	L-malate dehydrogenase activity
JCP76_06345	COG3037	sugar-specific permease SgaT UlaA
JCP76_06355	COG3711	transcriptional antiterminator
JCP76_06365	COG0673	inositol 2-dehydrogenase activity
JCP76_06415	COG0745	RESPONSE REGULATOR receiver
JCP76_06420	COG5002	protein histidine kinase activity
JCP76_06425	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
JCP76_06450	COG0351	phosphomethylpyrimidine kinase
JCP76_06460	COG4475	Protein of unknown function (DUF436)
JCP76_06465	COG0366	Alpha amylase catalytic
JCP76_06480	COG1307	EDD domain protein, DegV family
JCP76_06485	COG2244	polysaccharide biosynthetic process
JCP76_06535	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
JCP76_06540	COG0194	GDP metabolic process
JCP76_06565	COG0765	amino acid transport
JCP76_06570	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
JCP76_06580	COG0167	dihydroorotate dehydrogenase activity
JCP76_06595	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
JCP76_06605	COG3833	ABC-type maltose transport systems, permease component
JCP76_06610	COG1175	transmembrane transport
JCP76_06615	COG2182	Extracellular solute-binding protein
JCP76_06620	COG0366	Alpha amylase catalytic
JCP76_06625	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
JCP76_06635	COG1764	response to oxidative stress
JCP76_06640	COG1846	Transcriptional regulator
JCP76_06645	COG0628	permease
JCP76_06660	COG1312	Catalyzes the dehydration of D-mannonate
JCP76_06665	COG0246	Mannitol dehydrogenase
JCP76_06675	COG0450	alkyl hydroperoxide reductase
JCP76_06720	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
JCP76_06735	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
JCP76_06765	COG2946	Replication initiation factor
JCP76_06785	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
JCP76_06805	COG0004	ammonium transporteR
JCP76_06810	COG2261	transglycosylase associated protein
JCP76_06840	COG3655	Transcriptional regulator
JCP76_06855	COG2261	transglycosylase associated protein
JCP76_06875	COG1028	Short-chain dehydrogenase reductase Sdr
JCP76_06890	COG1442	glycosyl transferase family 8
JCP76_06895	COG1442	glycosyl transferase family 8
JCP76_06900	COG0561	phosphatase activity
JCP76_06925	COG1476	TRANSCRIPTIONal
JCP76_06940	COG1278	Cold shock
JCP76_06955	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
JCP76_06960	COG1312	Catalyzes the dehydration of D-mannonate
JCP76_06980	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
JCP76_06985	COG3716	PTS system mannose fructose sorbose family IID component
JCP76_06995	COG0371	Dehydrogenase
JCP76_07010	COG1023	phosphogluconate dehydrogenase (decarboxylating) activity
JCP76_07015	COG0837	glucose binding
JCP76_07015	COG1737	Transcriptional regulator
JCP76_07025	COG2272	Belongs to the type-B carboxylesterase lipase family
JCP76_07030	COG1073	alpha beta
JCP76_07065	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
JCP76_07085	COG3732	PTS system glucitol sorbitol-specific
JCP76_07090	COG3730	PTS system glucitol sorbitol-specific
JCP76_07100	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
JCP76_07100	COG3711	transcriptional antiterminator
JCP76_07125	COG3328	transposase activity
JCP76_07135	COG4974	Belongs to the 'phage' integrase family
JCP76_07140	COG0582	viral genome integration into host DNA
JCP76_07160	COG3250	beta-galactosidase activity
JCP76_07175	COG2211	Major facilitator Superfamily
JCP76_07185	COG1904	glucuronate isomerase
JCP76_07190	COG1312	Catalyzes the dehydration of D-mannonate
JCP76_07195	COG0246	Mannitol dehydrogenase
JCP76_07200	COG2188	Transcriptional regulator
JCP76_07255	COG0433	COG0433 Predicted ATPase
JCP76_07300	COG2946	Replication initiation factor
JCP76_07365	COG0481	GTPase activity
JCP76_07385	COG0542	response to heat
JCP76_07400	COG1597	lipid kinase activity
JCP76_07405	COG2195	Cleaves the N-terminal amino acid of tripeptides
JCP76_07410	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
JCP76_07415	COG2384	SAM-dependent methyltransferase
JCP76_07440	COG1484	DNA-dependent DNA replication
JCP76_07450	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
JCP76_07460	COG0237	dephospho-CoA kinase activity
JCP76_07465	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
JCP76_07470	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
JCP76_07470	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
JCP76_07485	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
JCP76_07490	COG1434	Gram-negative-bacterium-type cell wall biogenesis
JCP76_07495	COG3091	SprT-like family
JCP76_07500	COG2183	response to ionizing radiation
JCP76_07510	COG1054	Belongs to the UPF0176 family
JCP76_07525	COG0546	phosphoglycolate phosphatase activity
JCP76_07530	COG0588	phosphoglycerate mutase activity
JCP76_07575	COG4753	response regulator
JCP76_07575	COG2207	Transcriptional regulator
JCP76_07585	COG2972	Histidine kinase
JCP76_07590	COG0077	Prephenate dehydratase
JCP76_07595	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
JCP76_07600	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
JCP76_07605	COG0287	Prephenate dehydrogenase
JCP76_07610	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
JCP76_07620	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
JCP76_07625	COG3250	beta-galactosidase activity
JCP76_07640	COG1609	Transcriptional regulator
JCP76_07650	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
JCP76_07660	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
JCP76_07665	COG1597	lipid kinase activity
JCP76_07670	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
JCP76_07675	COG0154	amidase activity
JCP76_07680	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
JCP76_07685	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
JCP76_07690	COG0210	DNA helicase
JCP76_07700	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
JCP76_07700	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
JCP76_07700	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
JCP76_07705	COG1105	Belongs to the carbohydrate kinase PfkB family
JCP76_07710	COG1349	DNA-binding transcription factor activity
JCP76_07730	COG0218	Necessary for normal cell division and for the maintenance of normal septation
JCP76_07735	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
JCP76_07740	COG0544	peptidyl-prolyl cis-trans isomerase activity
JCP76_07750	COG1714	RDD family
JCP76_07765	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
JCP76_07775	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
JCP76_07845	COG1481	regulation of sporulation
JCP76_07850	COG0391	Required for morphogenesis under gluconeogenic growth conditions
JCP76_07855	COG1660	Displays ATPase and GTPase activities
JCP76_07870	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
JCP76_07875	COG0556	nucleotide-excision repair
JCP76_07880	COG0765	amino acid transport
JCP76_07885	COG1126	abc transporter atp-binding protein
JCP76_07890	COG0484	heat shock protein binding
JCP76_07895	COG0443	Heat shock 70 kDa protein
JCP76_07900	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
JCP76_07905	COG1420	regulation of RNA biosynthetic process
JCP76_07910	COG0635	Involved in the biosynthesis of porphyrin-containing compound
JCP76_07955	COG0693	protein deglycase activity
JCP76_07965	COG1619	proteins homologs of microcin C7 resistance protein MccF
JCP76_07975	COG5646	InterPro IPR014922
JCP76_07985	COG4975	Glucose uptake
JCP76_08000	COG0196	riboflavin kinase activity
JCP76_08005	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
JCP76_08010	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
JCP76_08015	COG1175	transmembrane transport
JCP76_08020	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
JCP76_08035	COG2740	Nucleic-acid-binding protein implicated in transcription termination
JCP76_08040	COG0195	Participates in both transcription termination and antitermination
JCP76_08045	COG0779	Required for maturation of 30S ribosomal subunits
JCP76_08050	COG2176	DNA-directed DNA polymerase activity
JCP76_08055	COG0442	prolyl-tRNA aminoacylation
JCP76_08060	COG0750	zinc metalloprotease
JCP76_08065	COG4589	Belongs to the CDS family
JCP76_08070	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
JCP76_08080	COG0233	cytoplasmic translational termination
JCP76_08085	COG0528	UMP kinase activity
JCP76_08090	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
JCP76_08095	COG0052	Belongs to the universal ribosomal protein uS2 family
JCP76_08100	COG1438	arginine binding
JCP76_08110	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
JCP76_08115	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
JCP76_08120	COG0018	arginyl-trna synthetase
JCP76_08135	COG2235	arginine
JCP76_08140	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
JCP76_08150	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
JCP76_08155	COG0456	acetyltransferase
JCP76_08165	COG1214	PFAM Peptidase M22, glycoprotease
JCP76_08175	COG1609	Transcriptional regulator
JCP76_08180	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
JCP76_08185	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
JCP76_08200	COG3189	MarR family transcriptional regulator
JCP76_08205	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
JCP76_08210	COG1940	carbohydrate kinase activity
JCP76_08225	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
JCP76_08230	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
JCP76_08235	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
JCP76_08240	COG1120	ATPase activity
JCP76_08255	COG0267	Belongs to the bacterial ribosomal protein bL33 family
JCP76_08260	COG4876	unkown
JCP76_08265	COG0367	asparagine synthase
JCP76_08270	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
JCP76_08280	COG1309	transcriptional regulator
JCP76_08300	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
JCP76_08315	COG0584	glycerophosphoryl diester phosphodiesterase
JCP76_08345	COG0166	Belongs to the GPI family
JCP76_08350	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
JCP76_08355	COG2081	HI0933 family
JCP76_08360	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
JCP76_08365	COG0710	3-dehydroquinate dehydratase activity
JCP76_08370	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
JCP76_08375	COG1368	sulfuric ester hydrolase activity
JCP76_08390	COG3850	Histidine kinase
JCP76_08390	COG5002	protein histidine kinase activity
JCP76_08395	COG0745	RESPONSE REGULATOR receiver
JCP76_08420	COG3328	transposase activity
JCP76_08435	COG3328	transposase activity
JCP76_08450	COG1956	GAF domain-containing protein
JCP76_08455	COG3527	Alpha-acetolactate decarboxylase
JCP76_08460	COG0028	Belongs to the TPP enzyme family
JCP76_08470	COG3328	transposase activity
JCP76_08480	COG0395	ABC-type sugar transport system, permease component
JCP76_08490	COG0583	DNA-binding transcription factor activity
JCP76_08495	COG0789	Transcriptional regulator
JCP76_08500	COG2814	Major facilitator Superfamily
JCP76_08555	COG4974	Belongs to the 'phage' integrase family
JCP76_08580	COG4372	Transposase
JCP76_08610	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
JCP76_08610	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
JCP76_08615	COG3716	PTS system mannose fructose sorbose family IID component
JCP76_08620	COG3715	PTS system
JCP76_08625	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
JCP76_08625	COG3933	PFAM sigma-54 factor interaction domain-containing protein
JCP76_08630	COG1940	carbohydrate kinase activity
JCP76_08635	COG2190	(PTS) system
JCP76_08650	COG1609	Transcriptional regulator
JCP76_08675	COG3385	transposase activity
JCP76_08695	COG0741	lytic transglycosylase activity
JCP76_08695	COG0791	NLP P60 protein
JCP76_08725	COG1196	nuclear chromosome segregation
JCP76_08755	COG2946	Replication initiation factor
JCP76_08770	COG1674	ftsk spoiiie
JCP76_08800	COG0335	large ribosomal subunit rRNA binding
JCP76_08805	COG0336	Belongs to the RNA methyltransferase TrmD family
JCP76_08810	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
JCP76_08820	COG1837	Belongs to the UPF0109 family
JCP76_08825	COG0228	four-way junction DNA binding
JCP76_08830	COG0431	NADPH-dependent FMN reductase
JCP76_08835	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
JCP76_08840	COG0519	Catalyzes the synthesis of GMP from XMP
JCP76_08845	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
JCP76_08850	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
JCP76_08860	COG0745	RESPONSE REGULATOR receiver
JCP76_08865	COG5002	protein histidine kinase activity
JCP76_08870	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
JCP76_08880	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
JCP76_08905	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
JCP76_08925	COG3328	transposase activity
JCP76_08965	COG0714	Associated with various cellular activities
JCP76_08985	COG2217	Heavy metal translocating P-type atpase
JCP76_08990	COG2217	Heavy metal translocating P-type atpase
JCP76_08995	COG2608	mercury ion transmembrane transporter activity
JCP76_09000	COG3682	Transcriptional regulator
JCP76_09010	COG0531	amino acid
JCP76_09015	COG2217	Heavy metal translocating P-type atpase
JCP76_09035	COG0017	Asparaginyl-tRNA synthetase
JCP76_09040	COG0436	Aminotransferase
JCP76_09050	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
JCP76_09050	COG1199	ATP-dependent helicase activity
JCP76_09055	COG1278	Cold shock
JCP76_09075	COG1686	Belongs to the peptidase S11 family
JCP76_09085	COG0038	chloride channel
JCP76_09100	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
JCP76_09105	COG1254	Belongs to the acylphosphatase family
JCP76_09110	COG0706	membrane insertase activity
JCP76_09115	COG3684	Belongs to the aldolase LacD family
JCP76_09120	COG4372	Transposase
JCP76_09180	COG1216	Glycosyl transferase, family 2
JCP76_09185	COG0438	transferase activity, transferring glycosyl groups
JCP76_09205	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
JCP76_09210	COG4464	protein tyrosine phosphatase activity
JCP76_09215	COG0489	protein tyrosine kinase activity
JCP76_09220	COG3944	biosynthesis protein
JCP76_09225	COG1316	TRANSCRIPTIONal
JCP76_09235	COG0751	glycine-tRNA ligase activity
JCP76_09240	COG0752	glycyl-tRNA synthetase alpha subunit
JCP76_09245	COG1381	Involved in DNA repair and RecF pathway recombination
JCP76_09250	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
JCP76_09255	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
JCP76_09260	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
JCP76_09270	COG1702	phosphate starvation-inducible protein PhoH
JCP76_09275	COG1114	Component of the transport system for branched-chain amino acids
JCP76_09280	COG1610	YqeY-like protein
JCP76_09285	COG0828	Belongs to the bacterial ribosomal protein bS21 family
JCP76_09290	COG0735	belongs to the Fur family
JCP76_09295	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
JCP76_09300	COG0640	Transcriptional regulator
JCP76_09305	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
JCP76_09310	COG0492	ferredoxin-NADP+ reductase activity
JCP76_09315	COG2723	6-phospho-beta-galactosidase activity
JCP76_09320	COG1486	melibiose metabolic process
JCP76_09325	COG1737	Transcriptional regulator
JCP76_09330	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
JCP76_09330	COG2190	(PTS) system
JCP76_09330	COG1263	PTS System
JCP76_09340	COG1132	(ABC) transporter
JCP76_09345	COG1132	(ABC) transporter
JCP76_09350	COG3763	UPF0154 protein
JCP76_09355	COG1914	H( )-stimulated, divalent metal cation uptake system
JCP76_09365	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
JCP76_09375	COG3328	transposase activity
JCP76_09410	COG1609	Transcriptional regulator
JCP76_09420	COG4980	gas vesicle protein
JCP76_09430	COG1210	Utp--glucose-1-phosphate uridylyltransferase
JCP76_09435	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
JCP76_09440	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
JCP76_09445	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
JCP76_09450	COG1950	PFAM Membrane protein of
JCP76_09475	COG0704	Plays a role in the regulation of phosphate uptake
JCP76_09480	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
JCP76_09485	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
JCP76_09490	COG0581	inorganic phosphate transmembrane transporter activity
JCP76_09495	COG0573	inorganic phosphate transmembrane transporter activity
JCP76_09500	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
JCP76_09505	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
JCP76_09510	COG2177	Part of the ABC transporter FtsEX involved in
JCP76_09515	COG2884	Cell division ATP-binding protein ftsE
JCP76_09525	COG0653	protein targeting
JCP76_09540	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
JCP76_09545	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
JCP76_09555	COG1739	Uncharacterized protein family UPF0029
JCP76_09560	COG2188	Transcriptional regulator
JCP76_09585	COG1940	carbohydrate kinase activity
JCP76_09605	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
JCP76_09620	COG0355	proton-transporting ATP synthase activity, rotational mechanism
JCP76_09625	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
JCP76_09630	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
JCP76_09635	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
JCP76_09640	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
JCP76_09645	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
JCP76_09650	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
JCP76_09655	COG0356	it plays a direct role in the translocation of protons across the membrane
JCP76_09665	COG1647	Serine aminopeptidase, S33
JCP76_09670	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
JCP76_09675	COG2388	GCN5-related N-acetyl-transferase
JCP76_09685	COG1957	nucleoside hydrolase
JCP76_09695	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
JCP76_09705	COG0149	triose-phosphate isomerase activity
JCP76_09710	COG0126	phosphoglycerate kinase activity
JCP76_09720	COG2390	Transcriptional regulator
JCP76_09725	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
JCP76_09745	COG1595	DNA-templated transcription, initiation
JCP76_09760	COG0095	Lipoate-protein ligase
JCP76_09765	COG1078	dGTPase activity
JCP76_09770	COG0561	phosphatase activity
JCP76_09775	COG0494	nUDIX hydrolase
JCP76_09780	COG0346	lactoylglutathione lyase activity
JCP76_09790	COG2423	ornithine cyclodeaminase activity
JCP76_09795	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
JCP76_09800	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
JCP76_09805	COG1394	ATPase activity, coupled to movement of substances
JCP76_09810	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
JCP76_09815	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
JCP76_09820	COG1436	Produces ATP from ADP in the presence of a proton gradient across the membrane
JCP76_09825	COG1527	subunit (C
JCP76_09830	COG1390	Produces ATP from ADP in the presence of a proton gradient across the membrane
JCP76_09835	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
JCP76_09840	COG1269	ATP hydrolysis coupled proton transport
JCP76_09850	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
JCP76_09855	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
JCP76_09865	COG4152	abc transporter atp-binding protein
JCP76_09870	COG0322	excinuclease ABC activity
JCP76_09880	COG3118	belongs to the thioredoxin family
JCP76_09885	COG1193	negative regulation of DNA recombination
JCP76_09900	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
JCP76_09915	COG1136	(ABC) transporter
JCP76_09925	COG0446	pyridine nucleotide-disulphide oxidoreductase
JCP76_09955	COG1304	FMN binding
JCP76_09965	COG0281	malic enzyme
JCP76_10005	COG4695	Portal protein
JCP76_10085	COG4974	Belongs to the 'phage' integrase family
JCP76_10090	COG3906	Belongs to the UPF0473 family
JCP76_10095	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
JCP76_10100	COG4472	Bacterial protein of unknown function (DUF965)
JCP76_10130	COG4555	ABC transporter
JCP76_10140	COG3689	TIGRFAM TIGR03943 family protein
JCP76_10145	COG0701	Predicted permease
JCP76_10150	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
JCP76_10155	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
JCP76_10160	COG0488	(ABC) transporter
JCP76_10165	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
JCP76_10180	COG0395	ABC-type sugar transport system, permease component
JCP76_10200	COG0662	Cupin 2, conserved barrel domain protein
JCP76_10200	COG2207	Transcriptional regulator
JCP76_10205	COG0446	pyridine nucleotide-disulphide oxidoreductase
JCP76_10220	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
JCP76_10225	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
JCP76_10230	COG0584	glycerophosphoryl diester phosphodiesterase
JCP76_10240	COG0740	serine-type endopeptidase activity
JCP76_10245	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
JCP76_10255	COG1132	(ABC) transporter
JCP76_10265	COG5503	Protein of unknown function (DUF1447)
JCP76_10280	COG1278	Cold shock
JCP76_10370	COG1196	nuclear chromosome segregation
JCP76_10370	COG0741	lytic transglycosylase activity
JCP76_10370	COG0739	heme binding
JCP76_10515	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
JCP76_10525	COG3723	Recombinational DNA repair protein, rece pathway
JCP76_10530	COG5377	YqaJ viral recombinase family
JCP76_10580	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
JCP76_10585	COG2003	Belongs to the UPF0758 family
JCP76_10590	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
JCP76_10595	COG0285	dihydrofolate synthase activity
JCP76_10600	COG0525	valine-tRNA ligase activity
JCP76_10605	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
JCP76_10610	COG0301	tRNA thio-modification
JCP76_10615	COG1104	cysteine desulfurase activity
JCP76_10625	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
JCP76_10635	COG0561	phosphatase activity
JCP76_10640	COG1801	Protein of unknown function DUF72
JCP76_10660	COG3579	cysteine-type endopeptidase activity
JCP76_10710	COG4372	Transposase
JCP76_10740	COG1098	S1 RNA binding domain
JCP76_10745	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
JCP76_10760	COG0492	ferredoxin-NADP+ reductase activity
JCP76_10765	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
JCP76_10780	COG4470	Protein conserved in bacteria
JCP76_10785	COG0737	Belongs to the 5'-nucleotidase family
JCP76_10795	COG0590	tRNA wobble adenosine to inosine editing
JCP76_10800	COG2508	Transcriptional regulator
JCP76_10810	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
JCP76_10810	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
JCP76_10825	COG2738	Putative neutral zinc metallopeptidase
JCP76_10830	COG2824	Alkylphosphonate utilization operon protein PhnA
JCP76_10835	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
JCP76_10840	COG4109	DRTGG domain
JCP76_10845	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
JCP76_10865	COG0577	efflux transmembrane transporter activity
JCP76_10870	COG1136	(ABC) transporter
JCP76_10880	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
JCP76_10885	COG1288	antiporter activity
JCP76_10890	COG4821	SIS domain
JCP76_10910	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
JCP76_10915	COG0279	D-glycero-D-manno-heptose 7-phosphate biosynthetic process
JCP76_10920	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
JCP76_10925	COG3716	PTS system mannose fructose sorbose family IID component
JCP76_10930	COG3715	PTS system
JCP76_10955	COG1132	(ABC) transporter
JCP76_10960	COG1132	(ABC) transporter
JCP76_10970	COG1803	Methylglyoxal synthase
JCP76_10975	COG3842	ATPase activity
JCP76_10985	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
JCP76_10990	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
JCP76_10995	COG0084	hydrolase, TatD family'
JCP76_11000	COG0531	amino acid
JCP76_11010	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
JCP76_11010	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
JCP76_11025	COG0675	Transposase, IS605 OrfB family
JCP76_11030	COG4608	Belongs to the ABC transporter superfamily
JCP76_11035	COG0444	Belongs to the ABC transporter superfamily
JCP76_11040	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
JCP76_11045	COG0601	transmembrane transport
JCP76_11055	COG4166	transmembrane transport
JCP76_11070	COG0820	rRNA (adenine-C2-)-methyltransferase activity
JCP76_11075	COG1280	lysine exporter protein (LysE YggA)
JCP76_11075	COG1674	ftsk spoiiie
JCP76_11080	COG2723	6-phospho-beta-galactosidase activity
JCP76_11085	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
JCP76_11090	COG1126	abc transporter atp-binding protein
JCP76_11095	COG0765	amino acid transport
JCP76_11140	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
JCP76_11150	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
JCP76_11155	COG0009	L-threonylcarbamoyladenylate synthase
JCP76_11165	COG2890	protein-(glutamine-N5) methyltransferase activity
JCP76_11170	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
JCP76_11175	COG1435	thymidine kinase activity
JCP76_11185	COG2226	methyltransferase
JCP76_11190	COG0681	Belongs to the peptidase S26 family
JCP76_11210	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
JCP76_11215	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
JCP76_11220	COG3442	glutamine amidotransferase
JCP76_11225	COG0246	Mannitol dehydrogenase
JCP76_11230	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
JCP76_11235	COG2213	PTS system mannitol-specific
JCP76_11240	COG1131	(ABC) transporter
JCP76_11250	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
JCP76_11255	COG3711	transcriptional antiterminator
JCP76_11260	COG2213	PTS system mannitol-specific
JCP76_11265	COG1482	cell wall glycoprotein biosynthetic process
JCP76_11280	COG1132	(ABC) transporter
JCP76_11300	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
JCP76_11310	COG0628	permease
JCP76_11320	COG2706	6-phosphogluconolactonase activity
JCP76_11335	COG1368	sulfuric ester hydrolase activity
JCP76_11345	COG2160	L-arabinose isomerase activity
JCP76_11350	COG0235	Class ii aldolase
JCP76_11370	COG3940	Belongs to the glycosyl hydrolase 43 family
JCP76_11375	COG3534	alpha-L-arabinofuranosidase
JCP76_11385	COG0395	ABC-type sugar transport system, permease component
JCP76_11390	COG1175	transmembrane transport
JCP76_11410	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
JCP76_11415	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
JCP76_11425	COG0789	Transcriptional regulator
JCP76_11430	COG1609	Transcriptional regulator
JCP76_11460	COG0459	protein refolding
JCP76_11465	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
JCP76_11475	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
JCP76_11480	COG2910	NAD(P)H-binding
JCP76_11485	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
JCP76_11500	COG5002	protein histidine kinase activity
JCP76_11505	COG0745	RESPONSE REGULATOR receiver
JCP76_11510	COG1307	EDD domain protein, DegV family
JCP76_11550	COG3448	diguanylate cyclase activity
JCP76_11550	COG4175	Glycine betaine
JCP76_11575	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
JCP76_11580	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
JCP76_11590	COG0628	permease
JCP76_11595	COG1285	pathogenesis
JCP76_11600	COG0363	glucosamine-6-phosphate deaminase activity
JCP76_11605	COG0488	(ABC) transporter
JCP76_11620	COG2814	Major facilitator Superfamily
JCP76_11630	COG0222	ribosome binding
JCP76_11635	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
JCP76_11640	COG0081	regulation of translation
JCP76_11645	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
JCP76_11650	COG1760	l-serine dehydratase
JCP76_11655	COG1760	l-serine dehydratase
JCP76_11660	COG1304	FMN binding
JCP76_11665	COG1075	acetyltransferases and hydrolases with the alpha beta hydrolase fold
JCP76_11670	COG0250	Participates in transcription elongation, termination and antitermination
JCP76_11675	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
JCP76_11680	COG0267	Belongs to the bacterial ribosomal protein bL33 family
JCP76_11695	COG1597	lipid kinase activity
JCP76_11710	COG1131	(ABC) transporter
JCP76_11715	COG4585	Histidine kinase
JCP76_11720	COG2197	response regulator
JCP76_11730	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
JCP76_11740	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
JCP76_11745	COG2226	methyltransferase
JCP76_11750	COG3142	Participates in the control of copper homeostasis
JCP76_11755	COG2239	Acts as a magnesium transporter
JCP76_11760	COG0564	pseudouridine synthase activity
JCP76_11765	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
JCP76_11770	COG2357	RelA SpoT domain protein
JCP76_11775	COG4116	CYTH
JCP76_11800	COG4862	establishment of competence for transformation
JCP76_11805	COG1393	Belongs to the ArsC family
JCP76_11820	COG0419	ATPase involved in DNA repair
JCP76_11825	COG0420	3'-5' exonuclease activity
JCP76_11830	COG0204	Acyl-transferase
JCP76_11835	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
JCP76_11840	COG2827	Endonuclease containing a URI domain
JCP76_11845	COG2755	lipolytic protein G-D-S-L family
JCP76_11845	COG1835	transferase activity, transferring acyl groups other than amino-acyl groups
JCP76_11850	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
JCP76_11855	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
JCP76_11860	COG0124	histidyl-tRNA synthetase
JCP76_11865	COG0667	Aldo Keto reductase
JCP76_11870	COG2124	cytochrome p450
JCP76_11875	COG1490	D-aminoacyl-tRNA deacylase activity
JCP76_11880	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
JCP76_11885	COG1385	rRNA (uridine-N3-)-methyltransferase activity
JCP76_11890	COG2264	protein methyltransferase activity
JCP76_11900	COG2094	Belongs to the DNA glycosylase MPG family
JCP76_11905	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
JCP76_11920	COG0589	response to stress
JCP76_11930	COG0488	(ABC) transporter
JCP76_11935	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
JCP76_11940	COG0827	DNA restriction-modification system
JCP76_11965	COG4537	Required for transformation and DNA binding
JCP76_11970	COG1459	type II secretion system
JCP76_11975	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
JCP76_11980	COG1001	Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family
JCP76_11985	COG0220	tRNA (guanine-N7-)-methyltransferase activity
JCP76_11995	COG4473	ABC transporter
JCP76_12000	COG1131	(ABC) transporter
JCP76_12005	COG0537	adenosine 5'-monophosphoramidase activity
JCP76_12015	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
JCP76_12020	COG3481	metal-dependent phosphohydrolase, HD sub domain
JCP76_12025	COG4717	serine-type aminopeptidase activity
JCP76_12030	COG0420	3'-5' exonuclease activity
JCP76_12035	COG0561	phosphatase activity
JCP76_12060	COG2211	Major facilitator Superfamily
JCP76_12065	COG3507	Belongs to the glycosyl hydrolase 43 family
JCP76_12080	COG1073	alpha beta
JCP76_12090	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
JCP76_12095	COG1653	transport
JCP76_12105	COG4209	transmembrane transport
JCP76_12110	COG0395	ABC-type sugar transport system, permease component
JCP76_12115	COG2207	Transcriptional regulator
JCP76_12120	COG1609	Transcriptional regulator
JCP76_12125	COG0246	Mannitol dehydrogenase
JCP76_12130	COG2721	sulfolactate sulfo-lyase activity
JCP76_12135	COG1904	glucuronate isomerase
JCP76_12140	COG2755	lipolytic protein G-D-S-L family
JCP76_12150	COG1132	(ABC) transporter
JCP76_12155	COG3679	Belongs to the UPF0342 family
JCP76_12160	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
JCP76_12165	COG0564	pseudouridine synthase activity
JCP76_12170	COG1940	carbohydrate kinase activity
JCP76_12175	COG0383	alpha-mannosidase activity
JCP76_12195	COG2207	Transcriptional regulator
JCP76_12195	COG4753	response regulator
JCP76_12200	COG2972	Histidine kinase
JCP76_12210	COG1653	transport
JCP76_12215	COG0395	ABC-type sugar transport system, permease component
JCP76_12220	COG1175	transmembrane transport
JCP76_12225	COG1187	pseudouridine synthase activity
JCP76_12230	COG2244	polysaccharide biosynthetic process
JCP76_12240	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
JCP76_12245	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
JCP76_12260	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
JCP76_12260	COG3711	transcriptional antiterminator
JCP76_12305	COG4978	Transcriptional regulator
JCP76_12305	COG0789	Transcriptional regulator
JCP76_12315	COG1132	(ABC) transporter
JCP76_12325	COG0495	leucyl-tRNA aminoacylation
JCP76_12330	COG1388	LysM domain
JCP76_12330	COG1705	Flagellar rod assembly protein muramidase FlgJ
JCP76_12335	COG0671	phosphoesterase, PA-phosphatase related
JCP76_12340	COG1242	4 iron, 4 sulfur cluster binding
JCP76_12345	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
JCP76_12395	COG0582	viral genome integration into host DNA
JCP76_12400	COG3328	transposase activity
JCP76_12415	COG1132	(ABC) transporter
JCP76_12420	COG1132	(ABC) transporter
JCP76_12435	COG0477	Major facilitator Superfamily
JCP76_12440	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
JCP76_12600	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
JCP76_12605	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
JCP76_12610	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
JCP76_12620	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
JCP76_12625	COG0037	tRNA processing
JCP76_12630	COG1098	S1 RNA binding domain
JCP76_12640	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
JCP76_12645	COG2244	polysaccharide biosynthetic process
JCP76_12650	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
JCP76_12655	COG0193	aminoacyl-tRNA hydrolase activity
JCP76_12660	COG0039	L-malate dehydrogenase activity
JCP76_12670	COG0217	transcriptional regulatory protein
JCP76_12695	COG1792	Involved in formation and maintenance of cell shape
JCP76_12705	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
JCP76_12710	COG1162	GTPase activity
JCP76_12715	COG0515	serine threonine protein kinase
JCP76_12715	COG2815	serine threonine protein kinase
JCP76_12720	COG0631	protein serine/threonine phosphatase activity
JCP76_12725	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
JCP76_12725	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
JCP76_12730	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
JCP76_12735	COG0242	peptide deformylase activity
JCP76_12740	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
JCP76_12745	COG1758	RNA polymerase activity
JCP76_12750	COG0194	GDP metabolic process
JCP76_12760	COG1561	YicC-like family, N-terminal region
JCP76_12770	COG1752	Esterase of the alpha-beta hydrolase superfamily
JCP76_12785	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
JCP76_12790	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
JCP76_12795	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
JCP76_12800	COG1108	ABC-type Mn2 Zn2 transport systems permease components
JCP76_12805	COG1121	(ABC) transporter
JCP76_12810	COG3443	Belongs to the bacterial solute-binding protein 9 family
JCP76_12810	COG0803	Belongs to the bacterial solute-binding protein 9 family
JCP76_12815	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
JCP76_12820	COG0392	lysyltransferase activity
JCP76_12820	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
JCP76_12825	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
JCP76_12835	COG1418	mRNA catabolic process
JCP76_12840	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
JCP76_12845	COG1546	Belongs to the CinA family
JCP76_12845	COG1058	Belongs to the CinA family
JCP76_12850	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
JCP76_12855	COG1426	Protein conserved in bacteria
JCP76_12860	COG0612	Peptidase, M16
JCP76_12865	COG0612	Peptidase, M16
JCP76_12870	COG1970	mechanosensitive ion channel activity
JCP76_12875	COG2153	protein acetylation
JCP76_12880	COG4466	Protein conserved in bacteria
JCP76_12890	COG3688	RNA-binding protein containing a PIN domain
JCP76_12895	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
JCP76_12900	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
JCP76_12905	COG0215	cysteine-tRNA ligase activity
JCP76_12910	COG1045	serine acetyltransferase
JCP76_12915	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
JCP76_12920	COG4956	integral membrane protein (PIN domain superfamily)
JCP76_12930	COG0756	dUTP diphosphatase activity
JCP76_12940	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
JCP76_12945	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
JCP76_12960	COG2814	Major facilitator Superfamily
JCP76_12980	COG0778	Nitroreductase
JCP76_12990	COG1705	Flagellar rod assembly protein muramidase FlgJ
JCP76_12990	COG1388	LysM domain
JCP76_12995	COG4221	oxidoreductase activity
JCP76_13005	COG0583	DNA-binding transcription factor activity
JCP76_13010	COG3711	transcriptional antiterminator
JCP76_13015	COG2190	(PTS) system
JCP76_13015	COG1263	PTS System
JCP76_13015	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
JCP76_13020	COG0702	epimerase
JCP76_13035	COG2207	Transcriptional regulator
JCP76_13035	COG3708	Transcriptional regulator
JCP76_13055	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
JCP76_13065	COG0604	alcohol dehydrogenase
JCP76_13070	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
JCP76_13075	COG0842	Transport permease protein
JCP76_13080	COG1131	(ABC) transporter
JCP76_13090	COG2205	protein histidine kinase activity
JCP76_13095	COG0745	RESPONSE REGULATOR receiver
JCP76_13135	COG2188	Transcriptional regulator
JCP76_13140	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
JCP76_13145	COG3716	PTS system mannose fructose sorbose family IID component
JCP76_13150	COG3715	PTS system
JCP76_13160	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
JCP76_13165	COG2222	sugar isomerase
JCP76_13270	COG1674	ftsk spoiiie
JCP76_13295	COG2946	Replication initiation factor
JCP76_13335	COG0741	lytic transglycosylase activity
JCP76_13335	COG0791	NLP P60 protein
JCP76_13360	COG2814	Major facilitator Superfamily
JCP76_13370	COG3942	CHAP domain
JCP76_13370	COG1705	Flagellar rod assembly protein muramidase FlgJ
JCP76_13375	COG0446	pyridine nucleotide-disulphide oxidoreductase
JCP76_13390	COG2207	Transcriptional regulator
JCP76_13390	COG3708	Transcriptional regulator
JCP76_13420	COG0523	cobalamin synthesis protein
JCP76_13440	COG0803	Belongs to the bacterial solute-binding protein 9 family
JCP76_13440	COG3443	Belongs to the bacterial solute-binding protein 9 family
JCP76_13455	COG0267	Belongs to the bacterial ribosomal protein bL33 family
JCP76_13465	COG0333	Belongs to the bacterial ribosomal protein bL32 family
JCP76_13470	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
JCP76_13475	COG1132	(ABC) transporter
JCP76_13480	COG1132	(ABC) transporter
JCP76_13490	COG1129	ABC transporter
JCP76_13500	COG1309	transcriptional regulator
JCP76_13535	COG4974	Belongs to the 'phage' integrase family
JCP76_13540	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
JCP76_13545	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
JCP76_13550	COG0783	Belongs to the Dps family
JCP76_13555	COG1070	Carbohydrate kinase
JCP76_13560	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
JCP76_13565	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
JCP76_13570	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
JCP76_13580	COG1554	hydrolase, family 65, central catalytic
JCP76_13585	COG0673	inositol 2-dehydrogenase activity
JCP76_13590	COG1082	Xylose isomerase domain protein TIM barrel
JCP76_13595	COG1063	alcohol dehydrogenase
JCP76_13600	COG0395	ABC-type sugar transport system, permease component
JCP76_13605	COG1175	transmembrane transport
JCP76_13610	COG1653	transport
JCP76_13615	COG0366	Alpha amylase catalytic
JCP76_13620	COG1609	Transcriptional regulator
JCP76_13625	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
JCP76_13630	COG0085	RNA polymerase activity
JCP76_13640	COG4120	Belongs to the binding-protein-dependent transport system permease family
JCP76_13650	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
JCP76_13650	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
JCP76_13665	COG0142	geranyltranstransferase activity
JCP76_13685	COG4939	FMN-binding domain protein
JCP76_13700	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
JCP76_13705	COG0826	peptidase U32
JCP76_13710	COG0826	peptidase U32
JCP76_13715	COG0542	response to heat
JCP76_13720	COG4463	regulation of RNA biosynthetic process
JCP76_13795	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
JCP76_13800	COG0516	GMP reductase activity
JCP76_13800	COG0517	IMP dehydrogenase activity
JCP76_13810	COG0012	GTP binding
JCP76_13815	COG4481	Protein conserved in bacteria
JCP76_13820	COG1475	DNA binding
JCP76_13825	COG1192	Involved in chromosome partitioning
JCP76_13830	COG0357	Ribosomal RNA small subunit methyltransferase G
JCP76_13835	COG0445	tRNA wobble uridine modification
JCP76_13840	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
JCP76_13850	COG1847	R3H domain protein
JCP76_13855	COG0706	membrane insertase activity
JCP76_13860	COG0594	ribonuclease P activity
JCP76_13865	COG0230	Belongs to the bacterial ribosomal protein bL34 family
JCP76_13935	COG1192	Involved in chromosome partitioning
JCP76_13955	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
JCP76_13965	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
JCP76_14010	COG0629	single-stranded DNA binding
JCP76_14110	COG3344	reverse transcriptase
JCP76_14195	COG4372	Transposase
JCP76_14215	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
JCP76_14220	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
JCP76_14225	COG0853	Catalyzes the pyruvoyl-dependent decarboxylation of aspartate to produce beta-alanine
JCP76_14240	COG3328	transposase activity
JCP76_14255	COG3328	transposase activity
JCP76_14270	COG2188	Transcriptional regulator
JCP76_14275	COG2222	sugar isomerase
JCP76_14280	COG3684	Belongs to the aldolase LacD family
JCP76_14290	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
JCP76_14300	COG4974	Belongs to the 'phage' integrase family
JCP76_14320	COG2190	(PTS) system
JCP76_14320	COG1263	PTS System
JCP76_14320	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
JCP76_14325	COG1263	PTS System
JCP76_14325	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
JCP76_14325	COG2190	(PTS) system
JCP76_14330	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
JCP76_14360	COG1609	Transcriptional regulator
JCP76_14365	COG1621	beta-fructofuranosidase activity
JCP76_14370	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
JCP76_14370	COG2190	(PTS) system
JCP76_14370	COG1263	PTS System
JCP76_14375	COG1940	carbohydrate kinase activity
JCP76_14410	COG4372	Transposase
JCP76_14420	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
JCP76_14435	COG3775	system Galactitol-specific IIC component
JCP76_14450	COG3328	transposase activity
JCP76_14595	COG2337	Toxic component of a toxin-antitoxin (TA) module
JCP76_14610	COG3344	reverse transcriptase
JCP76_14765	COG3715	PTS system
JCP76_14770	COG3716	PTS system mannose fructose sorbose family IID component
JCP76_14775	COG2222	sugar isomerase
JCP76_14780	COG3933	PFAM sigma-54 factor interaction domain-containing protein
JCP76_14780	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
JCP76_14785	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
JCP76_14790	COG3711	transcriptional antiterminator
JCP76_14815	COG2222	sugar isomerase
JCP76_14820	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
JCP76_14825	COG2188	Transcriptional regulator
JCP76_14845	COG1288	antiporter activity
JCP76_14890	COG3933	PFAM sigma-54 factor interaction domain-containing protein
JCP76_14890	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
JCP76_14895	COG2190	(PTS) system
JCP76_14895	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
JCP76_14895	COG1263	PTS System
JCP76_14900	COG2723	6-phospho-beta-galactosidase activity
JCP76_14905	COG3711	transcriptional antiterminator
JCP76_14915	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
JCP76_14925	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
JCP76_14930	COG2217	Heavy metal translocating P-type atpase
JCP76_14950	COG2217	Heavy metal translocating P-type atpase
JCP76_14975	COG0582	viral genome integration into host DNA
JCP76_15010	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
JCP76_15030	COG1136	(ABC) transporter
JCP76_15045	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
JCP76_15065	COG1387	Histidinol phosphatase and related hydrolases of the PHP family
JCP76_15080	COG0395	ABC-type sugar transport system, permease component
JCP76_15090	COG3842	ATPase activity
JCP76_15105	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
JCP76_15120	COG5002	protein histidine kinase activity
JCP76_15140	COG3409	Peptidoglycan-binding domain 1 protein
JCP76_15155	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
JCP76_15240	COG2226	methyltransferase
JCP76_15250	COG0456	acetyltransferase
JCP76_15270	COG2378	regulation of single-species biofilm formation
JCP76_15375	COG2826	transposase and inactivated derivatives, IS30 family
JCP76_15415	COG4115	mRNA cleavage
JCP76_15430	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
JCP76_15450	COG1192	Involved in chromosome partitioning