locus-tag	class	description
A6P53_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
A6P53_00010	COG0592	DNA-directed DNA polymerase activity
A6P53_00015	COG2501	S4 domain
A6P53_00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
A6P53_00025	COG0187	DNA topoisomerase II activity
A6P53_00035	COG0360	Binds together with S18 to 16S ribosomal RNA
A6P53_00040	COG0629	single-stranded DNA binding
A6P53_00045	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
A6P53_00060	COG0359	binds to the 23S rRNA
A6P53_00070	COG0305	Participates in initiation and elongation during chromosome replication
A6P53_00075	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
A6P53_00085	COG0488	(ABC) transporter
A6P53_00095	COG0028	Belongs to the TPP enzyme family
A6P53_00130	COG0518	GMP synthase (glutamine-hydrolyzing) activity
A6P53_00130	COG0519	Catalyzes the synthesis of GMP from XMP
A6P53_00135	COG1072	(Pantothenic acid kinase))
A6P53_00140	COG2813	Specifically methylates the guanine in position
A6P53_00155	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
A6P53_00160	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
A6P53_00165	COG0295	cytidine deaminase activity
A6P53_00170	COG1744	ABC transporter substrate-binding protein PnrA-like
A6P53_00190	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
A6P53_00200	COG0813	purine-nucleoside phosphorylase activity
A6P53_00205	COG0588	phosphoglycerate mutase activity
A6P53_00215	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
A6P53_00220	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
A6P53_00225	COG0049	tRNA binding
A6P53_00230	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
A6P53_00235	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
A6P53_00240	COG3711	transcriptional antiterminator
A6P53_00245	COG2190	(PTS) system
A6P53_00245	COG1263	PTS System
A6P53_00245	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A6P53_00255	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A6P53_00255	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
A6P53_00255	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A6P53_00260	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A6P53_00265	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A6P53_00265	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A6P53_00280	COG0051	transcription antitermination factor activity, RNA binding
A6P53_00285	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
A6P53_00290	COG0088	Forms part of the polypeptide exit tunnel
A6P53_00295	COG0089	rRNA binding
A6P53_00300	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
A6P53_00305	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
A6P53_00310	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
A6P53_00315	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
A6P53_00320	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
A6P53_00325	COG0255	Belongs to the universal ribosomal protein uL29 family
A6P53_00330	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
A6P53_00335	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
A6P53_00340	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
A6P53_00345	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
A6P53_00350	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
A6P53_00355	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
A6P53_00360	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
A6P53_00365	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
A6P53_00370	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
A6P53_00375	COG1841	ribosomal large subunit assembly
A6P53_00380	COG0200	Binds to the 23S rRNA
A6P53_00385	COG0201	protein transport
A6P53_00390	COG0563	adenylate kinase activity
A6P53_00395	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
A6P53_00400	COG0257	Belongs to the bacterial ribosomal protein bL36 family
A6P53_00405	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
A6P53_00410	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
A6P53_00415	COG0202	RNA polymerase activity
A6P53_00420	COG0203	ribosomal protein L17
A6P53_00425	COG1122	ATPase activity
A6P53_00430	COG1122	ATPase activity
A6P53_00440	COG0101	tRNA pseudouridine synthase activity
A6P53_00470	COG0227	Belongs to the bacterial ribosomal protein bL28 family
A6P53_00480	COG1461	Dihydroxyacetone kinase
A6P53_00485	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
A6P53_00490	COG0416	fatty acid biosynthetic process
A6P53_00495	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A6P53_00505	COG4608	Belongs to the ABC transporter superfamily
A6P53_00510	COG0601	transmembrane transport
A6P53_00525	COG0571	ribonuclease III activity
A6P53_00530	COG1196	nuclear chromosome segregation
A6P53_00535	COG0561	phosphatase activity
A6P53_00540	COG0552	protein localization to endoplasmic reticulum
A6P53_00550	COG1181	Belongs to the D-alanine--D-alanine ligase family
A6P53_00550	COG2918	glutathione biosynthetic process
A6P53_00580	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A6P53_00585	COG4605	iron ion homeostasis
A6P53_00590	COG4604	ABC transporter, ATP-binding protein
A6P53_00595	COG4607	ABC-type enterochelin transport system periplasmic component
A6P53_00610	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A6P53_00635	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
A6P53_00640	COG1380	Effector of murein hydrolase LrgA
A6P53_00645	COG1346	cytolysis
A6P53_00660	COG1028	Short-chain dehydrogenase reductase Sdr
A6P53_00665	COG4708	membrane
A6P53_00695	COG1268	BioY protein
A6P53_00700	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
A6P53_00710	COG0561	phosphatase activity
A6P53_00715	COG1692	metallophosphoesterase
A6P53_00725	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
A6P53_00740	COG1263	PTS System
A6P53_00740	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A6P53_00745	COG2188	Transcriptional regulator
A6P53_00750	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
A6P53_00755	COG0632	four-way junction helicase activity
A6P53_00760	COG2255	four-way junction helicase activity
A6P53_00770	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
A6P53_00785	COG1114	Component of the transport system for branched-chain amino acids
A6P53_00790	COG1113	amino acid transport
A6P53_00795	COG1126	abc transporter atp-binding protein
A6P53_00800	COG0765	amino acid transport
A6P53_00810	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
A6P53_00815	COG0110	maltose O-acetyltransferase activity
A6P53_00820	COG1827	regulation of RNA biosynthetic process
A6P53_00840	COG0242	peptide deformylase activity
A6P53_00845	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
A6P53_00850	COG1185	polyribonucleotide nucleotidyltransferase activity
A6P53_00860	COG3158	transport of potassium into the cell
A6P53_00870	COG1253	flavin adenine dinucleotide binding
A6P53_00880	COG0534	Mate efflux family protein
A6P53_00890	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
A6P53_00895	COG1187	pseudouridine synthase activity
A6P53_00900	COG1011	Hydrolase
A6P53_00905	COG0572	uridine kinase
A6P53_00925	COG1671	Belongs to the UPF0178 family
A6P53_00935	COG1181	Belongs to the D-alanine--D-alanine ligase family
A6P53_00940	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
A6P53_00950	COG0736	holo-[acyl-carrier-protein] synthase activity
A6P53_00955	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
A6P53_00960	COG2337	Toxic component of a toxin-antitoxin (TA) module
A6P53_00965	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
A6P53_00970	COG1064	alcohol dehydrogenase
A6P53_00980	COG0531	amino acid
A6P53_00990	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
A6P53_01015	COG1922	lipopolysaccharide N-acetylmannosaminouronosyltransferase activity
A6P53_01030	COG0438	transferase activity, transferring glycosyl groups
A6P53_01080	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
A6P53_01085	COG1764	response to oxidative stress
A6P53_01105	COG0343	queuine tRNA-ribosyltransferase activity
A6P53_01110	COG1862	Preprotein translocase
A6P53_01115	COG1454	alcohol dehydrogenase
A6P53_01115	COG1012	belongs to the aldehyde dehydrogenase family
A6P53_01125	COG1304	FMN binding
A6P53_01140	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
A6P53_01145	COG1428	Deoxynucleoside kinase
A6P53_01155	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
A6P53_01160	COG0291	Belongs to the bacterial ribosomal protein bL35 family
A6P53_01165	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
A6P53_01185	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
A6P53_01220	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
A6P53_01225	COG2376	Dihydroxyacetone kinase
A6P53_01230	COG1461	Dihydroxyacetone kinase
A6P53_01250	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
A6P53_01260	COG0531	amino acid
A6P53_01270	COG1609	Transcriptional regulator
A6P53_01280	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
A6P53_01290	COG2190	(PTS) system
A6P53_01290	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A6P53_01290	COG1263	PTS System
A6P53_01310	COG3479	Phenolic acid decarboxylase
A6P53_01315	COG1695	Transcriptional regulator
A6P53_01325	COG2814	Major facilitator Superfamily
A6P53_01340	COG1136	(ABC) transporter
A6P53_01340	COG0577	efflux transmembrane transporter activity
A6P53_01350	COG5002	protein histidine kinase activity
A6P53_01350	COG3850	Histidine kinase
A6P53_01385	COG1136	(ABC) transporter
A6P53_01395	COG3942	CHAP domain
A6P53_01395	COG1705	Flagellar rod assembly protein muramidase FlgJ
A6P53_01400	COG1609	Transcriptional regulator
A6P53_01420	COG0366	Alpha amylase catalytic
A6P53_01440	COG0628	permease
A6P53_01445	COG0803	Belongs to the bacterial solute-binding protein 9 family
A6P53_01445	COG3443	Belongs to the bacterial solute-binding protein 9 family
A6P53_01450	COG3279	Response regulator of the LytR AlgR family
A6P53_01475	COG0210	DNA helicase
A6P53_01480	COG1393	Belongs to the ArsC family
A6P53_01485	COG1393	Belongs to the ArsC family
A6P53_01505	COG0386	Belongs to the glutathione peroxidase family
A6P53_01515	COG0626	cystathionine gamma-synthase activity
A6P53_01520	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
A6P53_01525	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
A6P53_01555	COG1272	protein, Hemolysin III
A6P53_01560	COG0019	diaminopimelate decarboxylase activity
A6P53_01565	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
A6P53_01570	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
A6P53_01575	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
A6P53_01580	COG2171	N-acyltransferase activity
A6P53_01585	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
A6P53_01590	COG0527	aspartate kinase activity
A6P53_01595	COG1473	amidohydrolase
A6P53_01600	COG0436	Aminotransferase
A6P53_01605	COG0446	pyridine nucleotide-disulphide oxidoreductase
A6P53_01610	COG0662	Cupin 2, conserved barrel domain protein
A6P53_01610	COG2207	Transcriptional regulator
A6P53_01620	COG2211	Major facilitator Superfamily
A6P53_01650	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
A6P53_01665	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
A6P53_01670	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
A6P53_01675	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
A6P53_01680	COG0287	Prephenate dehydrogenase
A6P53_01690	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
A6P53_01695	COG0077	Prephenate dehydratase
A6P53_01700	COG0693	protein deglycase activity
A6P53_01715	COG4116	CYTH
A6P53_01720	COG2357	RelA SpoT domain protein
A6P53_01725	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
A6P53_01730	COG0564	pseudouridine synthase activity
A6P53_01735	COG2239	Acts as a magnesium transporter
A6P53_01740	COG3142	Participates in the control of copper homeostasis
A6P53_01750	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
A6P53_01755	COG0406	alpha-ribazole phosphatase activity
A6P53_01760	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
A6P53_01765	COG1597	lipid kinase activity
A6P53_01780	COG0267	Belongs to the bacterial ribosomal protein bL33 family
A6P53_01790	COG0250	Participates in transcription elongation, termination and antitermination
A6P53_01815	COG1760	l-serine dehydratase
A6P53_01820	COG1760	l-serine dehydratase
A6P53_01825	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
A6P53_01830	COG0081	regulation of translation
A6P53_01835	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
A6P53_01840	COG0222	ribosome binding
A6P53_01860	COG2814	Major facilitator Superfamily
A6P53_01870	COG2337	Toxic component of a toxin-antitoxin (TA) module
A6P53_01875	COG0488	(ABC) transporter
A6P53_01880	COG0363	glucosamine-6-phosphate deaminase activity
A6P53_01885	COG1285	pathogenesis
A6P53_01890	COG0628	permease
A6P53_01895	COG3711	transcriptional antiterminator
A6P53_01895	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
A6P53_01905	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A6P53_01910	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
A6P53_01915	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A6P53_01925	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
A6P53_01935	COG0235	Class ii aldolase
A6P53_01945	COG1070	Carbohydrate kinase
A6P53_01965	COG3715	PTS system
A6P53_01975	COG4821	SIS domain
A6P53_01985	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
A6P53_01990	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
A6P53_02010	COG4175	Glycine betaine
A6P53_02010	COG3448	diguanylate cyclase activity
A6P53_02020	COG2135	peptidase activity
A6P53_02040	COG1307	EDD domain protein, DegV family
A6P53_02050	COG0745	RESPONSE REGULATOR receiver
A6P53_02055	COG5002	protein histidine kinase activity
A6P53_02070	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
A6P53_02090	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
A6P53_02095	COG0459	protein refolding
A6P53_02110	COG1609	Transcriptional regulator
A6P53_02115	COG0789	Transcriptional regulator
A6P53_02135	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
A6P53_02140	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
A6P53_02145	COG1368	sulfuric ester hydrolase activity
A6P53_02155	COG2706	6-phosphogluconolactonase activity
A6P53_02165	COG0628	permease
A6P53_02170	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
A6P53_02185	COG1132	(ABC) transporter
A6P53_02200	COG1482	cell wall glycoprotein biosynthetic process
A6P53_02210	COG1869	D-ribose catabolic process
A6P53_02215	COG4975	Glucose uptake
A6P53_02275	COG3442	glutamine amidotransferase
A6P53_02280	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
A6P53_02285	COG1396	sequence-specific DNA binding
A6P53_02295	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
A6P53_02315	COG0681	Belongs to the peptidase S26 family
A6P53_02325	COG1435	thymidine kinase activity
A6P53_02330	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
A6P53_02335	COG2890	protein-(glutamine-N5) methyltransferase activity
A6P53_02340	COG0009	L-threonylcarbamoyladenylate synthase
A6P53_02345	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
A6P53_02355	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
A6P53_02380	COG0463	Glycosyl transferase, family 2
A6P53_02385	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
A6P53_02390	COG2855	membrane
A6P53_02400	COG0583	DNA-binding transcription factor activity
A6P53_02405	COG0772	Belongs to the SEDS family
A6P53_02410	COG1393	Belongs to the ArsC family
A6P53_02415	COG0509	glycine decarboxylation via glycine cleavage system
A6P53_02420	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
A6P53_02425	COG2011	ABC-type metal ion transport system permease component
A6P53_02430	COG1464	Belongs to the NlpA lipoprotein family
A6P53_02440	COG0719	Fe-S assembly protein
A6P53_02445	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
A6P53_02455	COG0719	Fe-S assembly protein
A6P53_02485	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
A6P53_02520	COG2222	sugar isomerase
A6P53_02525	COG3684	Belongs to the aldolase LacD family
A6P53_02530	COG1105	Belongs to the carbohydrate kinase PfkB family
A6P53_02545	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
A6P53_02545	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A6P53_02550	COG3715	PTS system
A6P53_02555	COG3716	PTS system mannose fructose sorbose family IID component
A6P53_02570	COG2197	response regulator
A6P53_02580	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
A6P53_02585	COG0531	amino acid
A6P53_02590	COG2957	Belongs to the agmatine deiminase family
A6P53_02600	COG1136	(ABC) transporter
A6P53_02620	COG1597	lipid kinase activity
A6P53_02625	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
A6P53_02630	COG2814	Major facilitator Superfamily
A6P53_02640	COG3764	Sortase (surface protein transpeptidase)
A6P53_02645	COG3711	transcriptional antiterminator
A6P53_02650	COG2190	(PTS) system
A6P53_02650	COG1263	PTS System
A6P53_02650	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A6P53_02655	COG2723	6-phospho-beta-galactosidase activity
A6P53_02660	COG2116	formate transmembrane transporter activity
A6P53_02665	COG2188	Transcriptional regulator
A6P53_02670	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
A6P53_02680	COG3964	amidohydrolase
A6P53_02710	COG1428	Deoxynucleoside kinase
A6P53_02725	COG2723	6-phospho-beta-galactosidase activity
A6P53_02730	COG3842	ATPase activity
A6P53_02735	COG1175	transmembrane transport
A6P53_02740	COG0395	ABC-type sugar transport system, permease component
A6P53_02755	COG0737	Belongs to the 5'-nucleotidase family
A6P53_02770	COG1368	sulfuric ester hydrolase activity
A6P53_02785	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
A6P53_02790	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
A6P53_02795	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
A6P53_02800	COG2011	ABC-type metal ion transport system permease component
A6P53_02805	COG1464	Belongs to the NlpA lipoprotein family
A6P53_02810	COG1473	amidohydrolase
A6P53_02825	COG1113	amino acid transport
A6P53_02840	COG0004	ammonium transporteR
A6P53_02845	COG0531	amino acid
A6P53_02860	COG1929	Belongs to the glycerate kinase type-1 family
A6P53_02865	COG0488	(ABC) transporter
A6P53_02880	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
A6P53_02885	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A6P53_02885	COG1263	PTS System
A6P53_02905	COG2076	Multidrug Resistance protein
A6P53_02920	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
A6P53_02930	COG3201	nicotinamide mononucleotide transporter
A6P53_02935	COG0346	lactoylglutathione lyase activity
A6P53_02965	COG0561	phosphatase activity
A6P53_02970	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
A6P53_02975	COG0280	phosphate acetyltransferase
A6P53_02980	COG0802	atpase or kinase
A6P53_02985	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
A6P53_03000	COG0708	Exodeoxyribonuclease III
A6P53_03010	COG0812	UDP-N-acetylmuramate dehydrogenase activity
A6P53_03015	COG0454	-acetyltransferase
A6P53_03015	COG0456	acetyltransferase
A6P53_03030	COG1053	succinate dehydrogenase
A6P53_03035	COG1755	Isoprenylcysteine carboxyl methyltransferase
A6P53_03045	COG0702	epimerase
A6P53_03050	COG4684	Psort location CytoplasmicMembrane, score
A6P53_03055	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
A6P53_03065	COG0604	alcohol dehydrogenase
A6P53_03075	COG3842	ATPase activity
A6P53_03080	COG1176	ABC-type spermidine putrescine transport system, permease component I
A6P53_03085	COG1177	transmembrane transport
A6P53_03090	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
A6P53_03110	COG1846	Transcriptional regulator
A6P53_03115	COG1132	(ABC) transporter
A6P53_03120	COG5002	protein histidine kinase activity
A6P53_03125	COG0745	RESPONSE REGULATOR receiver
A6P53_03130	COG0577	efflux transmembrane transporter activity
A6P53_03135	COG1136	(ABC) transporter
A6P53_03145	COG0488	(ABC) transporter
A6P53_03150	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
A6P53_03160	COG0602	queuosine metabolic process
A6P53_03165	COG1328	CTP reductase activity
A6P53_03170	COG1136	(ABC) transporter
A6P53_03175	COG0577	efflux transmembrane transporter activity
A6P53_03185	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
A6P53_03190	COG1696	Membrane protein involved in D-alanine export
A6P53_03195	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
A6P53_03200	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
A6P53_03205	COG1363	Peptidase, m42
A6P53_03215	COG1234	tRNA 3'-trailer cleavage
A6P53_03220	COG0095	Lipoate-protein ligase
A6P53_03245	COG3759	membrane
A6P53_03250	COG0659	secondary active sulfate transmembrane transporter activity
A6P53_03260	COG0261	This protein binds to 23S rRNA in the presence of protein L20
A6P53_03270	COG0211	Belongs to the bacterial ribosomal protein bL27 family
A6P53_03275	COG3594	Acyltransferase
A6P53_03280	COG3933	PFAM sigma-54 factor interaction domain-containing protein
A6P53_03280	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
A6P53_03285	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
A6P53_03285	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A6P53_03295	COG3715	PTS system
A6P53_03300	COG3716	PTS system mannose fructose sorbose family IID component
A6P53_03310	COG2261	transglycosylase associated protein
A6P53_03315	COG0006	proline dipeptidase activity
A6P53_03320	COG1302	Protein conserved in bacteria
A6P53_03325	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
A6P53_03330	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
A6P53_03335	COG1570	exodeoxyribonuclease VII activity
A6P53_03340	COG1722	exodeoxyribonuclease VII activity
A6P53_03345	COG0142	geranyltranstransferase activity
A6P53_03350	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
A6P53_03355	COG1438	arginine binding
A6P53_03360	COG0497	DNA recombination
A6P53_03385	COG4839	cell division protein FtsL
A6P53_03390	COG0768	penicillin binding
A6P53_03425	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
A6P53_03430	COG1799	cell septum assembly
A6P53_03435	COG0762	integral membrane protein
A6P53_03440	COG2302	S4 RNA-binding domain
A6P53_03445	COG3599	regulation of cell shape
A6P53_03450	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
A6P53_03470	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
A6P53_03475	COG1108	ABC-type Mn2 Zn2 transport systems permease components
A6P53_03475	COG1321	iron dependent repressor
A6P53_03490	COG0673	inositol 2-dehydrogenase activity
A6P53_03500	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
A6P53_03500	COG3933	PFAM sigma-54 factor interaction domain-containing protein
A6P53_03505	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
A6P53_03515	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
A6P53_03550	COG2309	aminopeptidase activity
A6P53_03560	COG0716	FMN binding
A6P53_03565	COG0024	Methionine aminopeptidase
A6P53_03570	COG1295	ribonuclease BN
A6P53_03575	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
A6P53_03590	COG1215	transferase activity, transferring glycosyl groups
A6P53_03595	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
A6P53_03600	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
A6P53_03605	COG1088	dTDP-glucose 4,6-dehydratase activity
A6P53_03610	COG1091	dTDP-4-dehydrorhamnose reductase activity
A6P53_03630	COG1682	transport, permease protein
A6P53_03640	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
A6P53_03645	COG1216	Glycosyl transferase, family 2
A6P53_03645	COG0438	transferase activity, transferring glycosyl groups
A6P53_03650	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
A6P53_03655	COG1216	Glycosyl transferase, family 2
A6P53_03660	COG3475	LICD family
A6P53_03675	COG1088	dTDP-glucose 4,6-dehydratase activity
A6P53_03680	COG1216	Glycosyl transferase, family 2
A6P53_03690	COG3475	LICD family
A6P53_03710	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
A6P53_03715	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
A6P53_03720	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
A6P53_03730	COG4585	Histidine kinase
A6P53_03740	COG0569	domain protein
A6P53_03745	COG4841	protein insertion into membrane
A6P53_03760	COG2246	polysaccharide biosynthetic process
A6P53_03765	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
A6P53_03770	COG1278	Cold shock
A6P53_03795	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
A6P53_03800	COG1316	TRANSCRIPTIONal
A6P53_03805	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
A6P53_03815	COG3397	chitin binding
A6P53_03825	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
A6P53_03830	COG2137	regulation of response to DNA damage stimulus
A6P53_03835	COG1194	a g-specific adenine glycosylase
A6P53_03840	COG3557	Belongs to the UPF0374 family
A6P53_03850	COG0628	permease
A6P53_03855	COG1253	flavin adenine dinucleotide binding
A6P53_03860	COG5492	domain, Protein
A6P53_03865	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
A6P53_03870	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
A6P53_03880	COG0542	response to heat
A6P53_03885	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
A6P53_03890	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
A6P53_03900	COG0438	transferase activity, transferring glycosyl groups
A6P53_03905	COG2084	Dehydrogenase
A6P53_03910	COG4703	Protein of unknown function (DUF1797)
A6P53_03920	COG1846	Transcriptional regulator
A6P53_03925	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
A6P53_03935	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
A6P53_03955	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
A6P53_03960	COG0439	Biotin carboxylase
A6P53_03965	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
A6P53_03970	COG0825	malonyl-CoA metabolic process
A6P53_03985	COG0765	amino acid transport
A6P53_03990	COG1126	abc transporter atp-binding protein
A6P53_04000	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
A6P53_04005	COG1534	Rna-binding protein
A6P53_04010	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
A6P53_04015	COG1713	HD superfamily hydrolase involved in NAD metabolism
A6P53_04020	COG0799	negative regulation of ribosome biogenesis
A6P53_04025	COG2226	methyltransferase
A6P53_04030	COG1323	Belongs to the UPF0348 family
A6P53_04035	COG0217	transcriptional regulatory protein
A6P53_04045	COG3973	AAA domain
A6P53_04055	COG1942	4-Oxalocrotonate Tautomerase
A6P53_04060	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
A6P53_04070	COG1737	Transcriptional regulator
A6P53_04075	COG0768	penicillin binding
A6P53_04080	COG0561	phosphatase activity
A6P53_04085	COG2252	PERMEase
A6P53_04090	COG2814	Major facilitator Superfamily
A6P53_04100	COG0587	DNA-directed DNA polymerase activity
A6P53_04105	COG0205	6-phosphofructokinase activity
A6P53_04115	COG0583	DNA-binding transcription factor activity
A6P53_04125	COG0333	Belongs to the bacterial ribosomal protein bL32 family
A6P53_04130	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
A6P53_04135	COG0745	RESPONSE REGULATOR receiver
A6P53_04140	COG5002	protein histidine kinase activity
A6P53_04250	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
A6P53_04260	COG2145	Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ)
A6P53_04265	COG0352	thiamine-phosphate diphosphorylase activity
A6P53_04265	COG0351	phosphomethylpyrimidine kinase
A6P53_04280	COG3732	PTS system glucitol sorbitol-specific
A6P53_04290	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
A6P53_04325	COG0346	lactoylglutathione lyase activity
A6P53_04330	COG2188	Transcriptional regulator
A6P53_04335	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
A6P53_04340	COG2723	6-phospho-beta-galactosidase activity
A6P53_04365	COG0589	response to stress
A6P53_04370	COG0351	phosphomethylpyrimidine kinase
A6P53_04380	COG1105	Belongs to the carbohydrate kinase PfkB family
A6P53_04385	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A6P53_04385	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
A6P53_04385	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A6P53_04395	COG3684	Belongs to the aldolase LacD family
A6P53_04430	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
A6P53_04445	COG3425	synthase
A6P53_04460	COG0772	Belongs to the SEDS family
A6P53_04465	COG0671	phosphoesterase, PA-phosphatase related
A6P53_04480	COG0656	L-ascorbic acid biosynthetic process
A6P53_04490	COG0346	lactoylglutathione lyase activity
A6P53_04505	COG0392	lysyltransferase activity
A6P53_04505	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
A6P53_04515	COG0741	lytic transglycosylase activity
A6P53_04525	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
A6P53_04530	COG0358	DNA primase activity
A6P53_04535	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
A6P53_04545	COG2996	Protein conserved in bacteria
A6P53_04550	COG0735	belongs to the Fur family
A6P53_04555	COG4974	Belongs to the 'phage' integrase family
A6P53_04565	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
A6P53_04570	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
A6P53_04575	COG1187	pseudouridine synthase activity
A6P53_04580	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
A6P53_04585	COG1288	antiporter activity
A6P53_04590	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A6P53_04600	COG1141	Ferredoxin
A6P53_04610	COG0514	ATP-dependent DNA helicase (RecQ)
A6P53_04615	COG1388	LysM domain
A6P53_04615	COG3942	CHAP domain
A6P53_04620	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
A6P53_04625	COG0539	negative regulation of cytoplasmic translation
A6P53_04630	COG1940	carbohydrate kinase activity
A6P53_04635	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A6P53_04635	COG1263	PTS System
A6P53_04635	COG2190	(PTS) system
A6P53_04640	COG1621	beta-fructofuranosidase activity
A6P53_04645	COG1609	Transcriptional regulator
A6P53_04650	COG1160	GTP binding
A6P53_04655	COG0776	regulation of translation
A6P53_04670	COG0457	Tetratricopeptide repeat
A6P53_04675	COG5582	Belongs to the UPF0302 family
A6P53_04680	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
A6P53_04685	COG1694	Mazg nucleotide pyrophosphohydrolase
A6P53_04690	COG0617	tRNA 3'-terminal CCA addition
A6P53_04705	COG0025	NhaP-type Na H and K H
A6P53_04710	COG2076	Multidrug Resistance protein
A6P53_04715	COG2076	Multidrug Resistance protein
A6P53_04720	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
A6P53_04725	COG0488	(ABC) transporter
A6P53_04730	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
A6P53_04740	COG1307	EDD domain protein, DegV family
A6P53_04745	COG2755	lipolytic protein G-D-S-L family
A6P53_04750	COG4698	Protein conserved in bacteria
A6P53_04760	COG4479	Belongs to the UPF0346 family
A6P53_04765	COG0681	Belongs to the peptidase S26 family
A6P53_04770	COG0095	Lipoate-protein ligase
A6P53_04790	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
A6P53_04795	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
A6P53_04800	COG0758	DNA mediated transformation
A6P53_04805	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
A6P53_04810	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
A6P53_04815	COG4974	Belongs to the 'phage' integrase family
A6P53_04820	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
A6P53_04825	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
A6P53_04830	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
A6P53_04840	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
A6P53_04845	COG1832	CoA-binding protein
A6P53_04850	COG0187	DNA topoisomerase II activity
A6P53_04860	COG1882	Formate acetyltransferase
A6P53_04865	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
A6P53_04875	COG1349	DNA-binding transcription factor activity
A6P53_04880	COG2207	Transcriptional regulator
A6P53_04910	COG4209	transmembrane transport
A6P53_04915	COG0395	ABC-type sugar transport system, permease component
A6P53_04925	COG2723	6-phospho-beta-galactosidase activity
A6P53_04930	COG1227	inorganic diphosphatase activity
A6P53_04955	COG1609	Transcriptional regulator
A6P53_04965	COG0604	alcohol dehydrogenase
A6P53_04970	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
A6P53_04980	COG1732	Glycine betaine
A6P53_05025	COG3942	CHAP domain
A6P53_05025	COG1388	LysM domain
A6P53_05040	COG0436	Aminotransferase
A6P53_05070	COG3037	sugar-specific permease SgaT UlaA
A6P53_05085	COG3623	hexulose-6-phosphate isomerase
A6P53_05095	COG0789	Transcriptional regulator
A6P53_05100	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
A6P53_05110	COG2268	Band 7 protein
A6P53_05120	COG4129	membrane
A6P53_05135	COG1876	peptidase activity
A6P53_05150	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
A6P53_05155	COG2233	PERMEase
A6P53_05170	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
A6P53_05175	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
A6P53_05180	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
A6P53_05190	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
A6P53_05195	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
A6P53_05200	COG0047	phosphoribosylformylglycinamidine synthase activity
A6P53_05205	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
A6P53_05215	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
A6P53_05220	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
A6P53_05225	COG0138	bifunctional purine biosynthesis protein purh
A6P53_05230	COG0151	Belongs to the GarS family
A6P53_05235	COG4989	oxidoreductase activity
A6P53_05245	COG0516	GMP reductase activity
A6P53_05250	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A6P53_05260	COG0022	dehydrogenase e1 component
A6P53_05315	COG4476	Belongs to the UPF0223 family
A6P53_05320	COG0483	inositol monophosphate 1-phosphatase activity
A6P53_05330	COG0514	ATP-dependent DNA helicase (RecQ)
A6P53_05335	COG4838	Belongs to the UPF0358 family
A6P53_05340	COG0772	Belongs to the SEDS family
A6P53_05345	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
A6P53_05355	COG3679	Belongs to the UPF0342 family
A6P53_05360	COG4471	UPF0298 protein
A6P53_05365	COG0742	ribosomal rna small subunit methyltransferase
A6P53_05370	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
A6P53_05375	COG3480	Lon protease (S16) C-terminal proteolytic domain
A6P53_05390	COG2131	deaminase
A6P53_05395	COG0658	competence protein
A6P53_05395	COG2333	competence protein COMEC
A6P53_05400	COG1466	dna polymerase III delta subunit
A6P53_05405	COG0268	Binds directly to 16S ribosomal RNA
A6P53_05415	COG2707	UPF0756 membrane protein
A6P53_05420	COG2217	Heavy metal translocating P-type atpase
A6P53_05425	COG1968	undecaprenyl-diphosphatase activity
A6P53_05440	COG1199	ATP-dependent helicase activity
A6P53_05440	COG1199	ATP-dependent helicase activity
A6P53_05445	COG1666	GTP binding
A6P53_05450	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
A6P53_05455	COG2151	metal-sulfur cluster biosynthetic enzyme
A6P53_05480	COG1388	LysM domain
A6P53_05480	COG3942	CHAP domain
A6P53_05530	COG4990	cell redox homeostasis
A6P53_05560	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
A6P53_05565	COG1074	ATP-dependent DNA helicase activity
A6P53_05570	COG1733	regulation of RNA biosynthetic process
A6P53_05575	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
A6P53_05580	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A6P53_05580	COG0072	phenylalanine-tRNA ligase activity
A6P53_05590	COG1126	abc transporter atp-binding protein
A6P53_05595	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A6P53_05600	COG0765	amino acid transport
A6P53_05605	COG0765	amino acid transport
A6P53_05640	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
A6P53_05645	COG2096	Adenosyltransferase
A6P53_05670	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
A6P53_05685	COG0517	IMP dehydrogenase activity
A6P53_05690	COG0668	transmembrane transport
A6P53_05695	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
A6P53_05700	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
A6P53_05705	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
A6P53_05710	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
A6P53_05735	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
A6P53_05745	COG1234	tRNA 3'-trailer cleavage
A6P53_05750	COG0300	oxidoreductase activity
A6P53_05755	COG5416	Lipopolysaccharide assembly protein A domain
A6P53_05760	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
A6P53_05760	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
A6P53_05765	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
A6P53_05775	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
A6P53_05790	COG1705	Flagellar rod assembly protein muramidase FlgJ
A6P53_05790	COG1388	LysM domain
A6P53_05800	COG0735	belongs to the Fur family
A6P53_05805	COG0446	pyridine nucleotide-disulphide oxidoreductase
A6P53_05820	COG3935	DnaD domain protein
A6P53_05825	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
A6P53_05830	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
A6P53_05835	COG3331	DNA recombination
A6P53_05840	COG4474	Belongs to the UPF0398 family
A6P53_05845	COG3599	regulation of cell shape
A6P53_05855	COG0116	Belongs to the methyltransferase superfamily
A6P53_05860	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
A6P53_05865	COG1418	mRNA catabolic process
A6P53_05875	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
A6P53_05880	COG0531	amino acid
A6P53_05895	COG0513	Belongs to the DEAD box helicase family
A6P53_05905	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
A6P53_05910	COG4684	Psort location CytoplasmicMembrane, score
A6P53_05920	COG0328	RNA-DNA hybrid ribonuclease activity
A6P53_05940	COG1278	Cold shock
A6P53_05970	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
A6P53_05975	COG0564	pseudouridine synthase activity
A6P53_05980	COG2065	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant
A6P53_05985	COG2233	PERMEase
A6P53_05990	COG0540	Belongs to the ATCase OTCase family
A6P53_05995	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
A6P53_06000	COG0505	Belongs to the CarA family
A6P53_06005	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
A6P53_06010	COG0543	2 iron, 2 sulfur cluster binding
A6P53_06015	COG0167	dihydroorotate dehydrogenase activity
A6P53_06020	COG0284	orotidine-5'-phosphate decarboxylase activity
A6P53_06025	COG0461	Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP)
A6P53_06060	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
A6P53_06065	COG2011	ABC-type metal ion transport system permease component
A6P53_06070	COG1464	Belongs to the NlpA lipoprotein family
A6P53_06090	COG4120	Belongs to the binding-protein-dependent transport system permease family
A6P53_06095	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
A6P53_06100	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
A6P53_06105	COG1316	TRANSCRIPTIONal
A6P53_06175	COG0039	L-malate dehydrogenase activity
A6P53_06190	COG0673	inositol 2-dehydrogenase activity
A6P53_06195	COG1737	Transcriptional regulator
A6P53_06230	COG0351	phosphomethylpyrimidine kinase
A6P53_06240	COG4475	Protein of unknown function (DUF436)
A6P53_06245	COG0366	Alpha amylase catalytic
A6P53_06260	COG1307	EDD domain protein, DegV family
A6P53_06265	COG2244	polysaccharide biosynthetic process
A6P53_06305	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
A6P53_06310	COG0194	GDP metabolic process
A6P53_06345	COG2011	ABC-type metal ion transport system permease component
A6P53_06350	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
A6P53_06365	COG1921	L-seryl-tRNASec selenium transferase activity
A6P53_06370	COG1104	cysteine desulfurase activity
A6P53_06390	COG0709	Synthesizes selenophosphate from selenide and ATP
A6P53_06405	COG0252	asparaginase activity
A6P53_06405	COG5275	peptidyl-tyrosine sulfation
A6P53_06415	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
A6P53_06420	COG1978	Selenoprotein B, glycine betaine sarcosine D-proline reductase family
A6P53_06430	COG5275	peptidyl-tyrosine sulfation
A6P53_06430	COG0252	asparaginase activity
A6P53_06435	COG4656	Part of a membrane complex involved in electron transport
A6P53_06445	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
A6P53_06450	COG5521	maltodextrose utilization protein MalA
A6P53_06455	COG3833	ABC-type maltose transport systems, permease component
A6P53_06460	COG1175	transmembrane transport
A6P53_06465	COG2182	Extracellular solute-binding protein
A6P53_06470	COG0366	Alpha amylase catalytic
A6P53_06475	COG4948	Mandelate Racemase Muconate Lactonizing
A6P53_06480	COG0596	Alpha beta hydrolase
A6P53_06485	COG1165	Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate (SEPHCHC)
A6P53_06495	COG0318	PFAM AMP-dependent synthetase and ligase
A6P53_06500	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
A6P53_06510	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
A6P53_06515	COG1764	response to oxidative stress
A6P53_06520	COG1846	Transcriptional regulator
A6P53_06525	COG0628	permease
A6P53_06530	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
A6P53_06545	COG0450	alkyl hydroperoxide reductase
A6P53_06550	COG3634	alkyl hydroperoxide reductase activity
A6P53_06585	COG1316	TRANSCRIPTIONal
A6P53_06595	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
A6P53_06600	COG0666	response to abiotic stimulus
A6P53_06615	COG2261	transglycosylase associated protein
A6P53_06640	COG4512	PFAM Accessory gene regulator B
A6P53_06645	COG3279	Response regulator of the LytR AlgR family
A6P53_06660	COG3655	Transcriptional regulator
A6P53_06690	COG1028	Short-chain dehydrogenase reductase Sdr
A6P53_06705	COG1442	glycosyl transferase family 8
A6P53_06710	COG1442	glycosyl transferase family 8
A6P53_06715	COG0561	phosphatase activity
A6P53_06745	COG1278	Cold shock
A6P53_06780	COG1940	carbohydrate kinase activity
A6P53_06785	COG2723	6-phospho-beta-galactosidase activity
A6P53_06805	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
A6P53_06825	COG1278	Cold shock
A6P53_06835	COG0481	GTPase activity
A6P53_06855	COG0542	response to heat
A6P53_06870	COG1597	lipid kinase activity
A6P53_06875	COG2195	Cleaves the N-terminal amino acid of tripeptides
A6P53_06880	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
A6P53_06885	COG2384	SAM-dependent methyltransferase
A6P53_06895	COG1484	DNA-dependent DNA replication
A6P53_06905	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
A6P53_06970	COG0237	dephospho-CoA kinase activity
A6P53_06975	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
A6P53_06980	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
A6P53_06980	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
A6P53_06995	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
A6P53_07000	COG1434	Gram-negative-bacterium-type cell wall biogenesis
A6P53_07005	COG3091	SprT-like family
A6P53_07010	COG2183	response to ionizing radiation
A6P53_07015	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
A6P53_07045	COG0546	phosphoglycolate phosphatase activity
A6P53_07050	COG0588	phosphoglycerate mutase activity
A6P53_07090	COG2723	6-phospho-beta-galactosidase activity
A6P53_07095	COG1940	carbohydrate kinase activity
A6P53_07100	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
A6P53_07110	COG2207	Transcriptional regulator
A6P53_07110	COG3708	Transcriptional regulator
A6P53_07140	COG4753	response regulator
A6P53_07140	COG2207	Transcriptional regulator
A6P53_07145	COG2972	Histidine kinase
A6P53_07150	COG3250	beta-galactosidase activity
A6P53_07175	COG1132	(ABC) transporter
A6P53_07180	COG1132	(ABC) transporter
A6P53_07205	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
A6P53_07210	COG1597	lipid kinase activity
A6P53_07215	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
A6P53_07220	COG0154	amidase activity
A6P53_07225	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
A6P53_07230	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
A6P53_07235	COG0210	DNA helicase
A6P53_07240	COG0038	chloride channel
A6P53_07265	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A6P53_07265	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A6P53_07265	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
A6P53_07270	COG1105	Belongs to the carbohydrate kinase PfkB family
A6P53_07275	COG1349	DNA-binding transcription factor activity
A6P53_07285	COG0218	Necessary for normal cell division and for the maintenance of normal septation
A6P53_07290	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
A6P53_07295	COG0544	peptidyl-prolyl cis-trans isomerase activity
A6P53_07305	COG1714	RDD family
A6P53_07320	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
A6P53_07345	COG1624	Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria
A6P53_07370	COG1481	regulation of sporulation
A6P53_07380	COG1660	Displays ATPase and GTPase activities
A6P53_07395	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
A6P53_07400	COG0556	nucleotide-excision repair
A6P53_07410	COG1126	abc transporter atp-binding protein
A6P53_07415	COG0484	heat shock protein binding
A6P53_07420	COG0443	Heat shock 70 kDa protein
A6P53_07425	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
A6P53_07430	COG1420	regulation of RNA biosynthetic process
A6P53_07435	COG0635	Involved in the biosynthesis of porphyrin-containing compound
A6P53_07500	COG0477	Major facilitator Superfamily
A6P53_07505	COG1695	Transcriptional regulator
A6P53_07535	COG1653	transport
A6P53_07540	COG0395	ABC-type sugar transport system, permease component
A6P53_07545	COG4209	transmembrane transport
A6P53_07550	COG2207	Transcriptional regulator
A6P53_07550	COG4753	response regulator
A6P53_07555	COG2972	Histidine kinase
A6P53_07600	COG1114	Component of the transport system for branched-chain amino acids
A6P53_07625	COG0196	riboflavin kinase activity
A6P53_07630	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
A6P53_07635	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
A6P53_07650	COG2740	Nucleic-acid-binding protein implicated in transcription termination
A6P53_07655	COG0195	Participates in both transcription termination and antitermination
A6P53_07660	COG0779	Required for maturation of 30S ribosomal subunits
A6P53_07665	COG2176	DNA-directed DNA polymerase activity
A6P53_07670	COG1733	regulation of RNA biosynthetic process
A6P53_07675	COG0656	L-ascorbic acid biosynthetic process
A6P53_07680	COG1028	Short-chain dehydrogenase reductase Sdr
A6P53_07685	COG0442	prolyl-tRNA aminoacylation
A6P53_07690	COG0750	zinc metalloprotease
A6P53_07695	COG4589	Belongs to the CDS family
A6P53_07700	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
A6P53_07705	COG0233	cytoplasmic translational termination
A6P53_07710	COG0528	UMP kinase activity
A6P53_07715	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
A6P53_07720	COG0052	Belongs to the universal ribosomal protein uS2 family
A6P53_07725	COG1438	arginine binding
A6P53_07730	COG0018	arginyl-trna synthetase
A6P53_07745	COG2235	arginine
A6P53_07750	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
A6P53_07755	COG1215	transferase activity, transferring glycosyl groups
A6P53_07795	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
A6P53_07800	COG0456	acetyltransferase
A6P53_07810	COG1214	PFAM Peptidase M22, glycoprotease
A6P53_07815	COG1609	Transcriptional regulator
A6P53_07820	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
A6P53_07825	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
A6P53_07835	COG3189	MarR family transcriptional regulator
A6P53_07845	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
A6P53_07850	COG1940	carbohydrate kinase activity
A6P53_07860	COG0705	Rhomboid family
A6P53_07860	COG0457	Tetratricopeptide repeat
A6P53_07865	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
A6P53_07870	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A6P53_07875	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
A6P53_07880	COG1120	ATPase activity
A6P53_07895	COG0267	Belongs to the bacterial ribosomal protein bL33 family
A6P53_07900	COG4876	unkown
A6P53_07905	COG0367	asparagine synthase
A6P53_07910	COG0463	Glycosyl transferase, family 2
A6P53_07950	COG3942	CHAP domain
A6P53_07950	COG1388	LysM domain
A6P53_07955	COG4974	Belongs to the 'phage' integrase family
A6P53_07965	COG1309	transcriptional regulator
A6P53_07980	COG0398	Pfam SNARE associated Golgi protein
A6P53_07985	COG0584	glycerophosphoryl diester phosphodiesterase
A6P53_08025	COG5632	N-Acetylmuramoyl-L-alanine amidase
A6P53_08025	COG5263	repeat protein
A6P53_08065	COG0739	heme binding
A6P53_08065	COG0741	lytic transglycosylase activity
A6P53_08065	COG1196	nuclear chromosome segregation
A6P53_08200	COG3935	DnaD domain protein
A6P53_08205	COG3723	Recombinational DNA repair protein, rece pathway
A6P53_08210	COG5377	YqaJ viral recombinase family
A6P53_08250	COG1396	sequence-specific DNA binding
A6P53_08265	COG4974	Belongs to the 'phage' integrase family
A6P53_08270	COG0166	Belongs to the GPI family
A6P53_08275	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
A6P53_08280	COG2081	HI0933 family
A6P53_08285	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
A6P53_08295	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
A6P53_08300	COG1368	sulfuric ester hydrolase activity
A6P53_08315	COG3850	Histidine kinase
A6P53_08315	COG5002	protein histidine kinase activity
A6P53_08320	COG0745	RESPONSE REGULATOR receiver
A6P53_08355	COG4932	domain protein
A6P53_08355	COG4886	Leucine-rich repeat (LRR) protein
A6P53_08360	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
A6P53_08365	COG0778	Nitroreductase
A6P53_08370	COG1846	Transcriptional regulator
A6P53_08445	COG1956	GAF domain-containing protein
A6P53_08450	COG3527	Alpha-acetolactate decarboxylase
A6P53_08455	COG0028	Belongs to the TPP enzyme family
A6P53_08460	COG1247	-acetyltransferase
A6P53_08465	COG2964	Protein conserved in bacteria
A6P53_08475	COG0446	pyridine nucleotide-disulphide oxidoreductase
A6P53_08480	COG0251	oxidation-reduction process
A6P53_08485	COG0626	cystathionine gamma-synthase activity
A6P53_08490	COG0789	Transcriptional regulator
A6P53_08500	COG1349	DNA-binding transcription factor activity
A6P53_08510	COG0745	RESPONSE REGULATOR receiver
A6P53_08515	COG2205	protein histidine kinase activity
A6P53_08520	COG2156	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit acts as a catalytic chaperone that increases the ATP- binding affinity of the ATP-hydrolyzing subunit KdpB by the formation of a transient KdpB KdpC ATP ternary complex
A6P53_08525	COG2216	Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system
A6P53_08535	COG3684	Belongs to the aldolase LacD family
A6P53_08540	COG0698	ribose 5-phosphate isomerase
A6P53_08550	COG2723	6-phospho-beta-galactosidase activity
A6P53_08565	COG1349	DNA-binding transcription factor activity
A6P53_08570	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
A6P53_08580	COG2723	6-phospho-beta-galactosidase activity
A6P53_08585	COG2188	Transcriptional regulator
A6P53_08590	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
A6P53_08595	COG0335	large ribosomal subunit rRNA binding
A6P53_08600	COG0336	Belongs to the RNA methyltransferase TrmD family
A6P53_08605	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
A6P53_08615	COG1837	Belongs to the UPF0109 family
A6P53_08620	COG0228	four-way junction DNA binding
A6P53_08630	COG1131	(ABC) transporter
A6P53_08640	COG0431	NADPH-dependent FMN reductase
A6P53_08650	COG0519	Catalyzes the synthesis of GMP from XMP
A6P53_08655	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
A6P53_08660	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
A6P53_08665	COG1683	Conserved Protein
A6P53_08670	COG0745	RESPONSE REGULATOR receiver
A6P53_08675	COG5002	protein histidine kinase activity
A6P53_08680	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
A6P53_08685	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
A6P53_08725	COG2217	Heavy metal translocating P-type atpase
A6P53_08730	COG2217	Heavy metal translocating P-type atpase
A6P53_08735	COG2608	mercury ion transmembrane transporter activity
A6P53_08740	COG3682	Transcriptional regulator
A6P53_08750	COG0531	amino acid
A6P53_08755	COG2217	Heavy metal translocating P-type atpase
A6P53_08775	COG0017	Asparaginyl-tRNA synthetase
A6P53_08780	COG0436	Aminotransferase
A6P53_08790	COG1199	ATP-dependent helicase activity
A6P53_08790	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
A6P53_08795	COG1278	Cold shock
A6P53_08805	COG1686	Belongs to the peptidase S11 family
A6P53_08815	COG0038	chloride channel
A6P53_08830	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
A6P53_08835	COG1254	Belongs to the acylphosphatase family
A6P53_08840	COG0706	membrane insertase activity
A6P53_08855	COG0438	transferase activity, transferring glycosyl groups
A6P53_08860	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
A6P53_08865	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
A6P53_08880	COG4464	protein tyrosine phosphatase activity
A6P53_08885	COG0489	protein tyrosine kinase activity
A6P53_08895	COG0751	glycine-tRNA ligase activity
A6P53_08900	COG0752	glycyl-tRNA synthetase alpha subunit
A6P53_08905	COG1381	Involved in DNA repair and RecF pathway recombination
A6P53_08910	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
A6P53_08915	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
A6P53_08920	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
A6P53_08930	COG1702	phosphate starvation-inducible protein PhoH
A6P53_08935	COG1610	YqeY-like protein
A6P53_08940	COG0828	Belongs to the bacterial ribosomal protein bS21 family
A6P53_08945	COG0735	belongs to the Fur family
A6P53_08950	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
A6P53_08955	COG0640	Transcriptional regulator
A6P53_08960	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
A6P53_08970	COG0492	ferredoxin-NADP+ reductase activity
A6P53_08975	COG2723	6-phospho-beta-galactosidase activity
A6P53_08980	COG1486	melibiose metabolic process
A6P53_08990	COG1132	(ABC) transporter
A6P53_08995	COG1132	(ABC) transporter
A6P53_09000	COG3763	UPF0154 protein
A6P53_09010	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
A6P53_09030	COG1609	Transcriptional regulator
A6P53_09040	COG4980	gas vesicle protein
A6P53_09050	COG1210	Utp--glucose-1-phosphate uridylyltransferase
A6P53_09055	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
A6P53_09060	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
A6P53_09065	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
A6P53_09070	COG1950	PFAM Membrane protein of
A6P53_09090	COG0704	Plays a role in the regulation of phosphate uptake
A6P53_09095	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
A6P53_09100	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
A6P53_09105	COG0581	inorganic phosphate transmembrane transporter activity
A6P53_09110	COG0573	inorganic phosphate transmembrane transporter activity
A6P53_09115	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
A6P53_09120	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
A6P53_09125	COG2177	Part of the ABC transporter FtsEX involved in
A6P53_09130	COG2884	Cell division ATP-binding protein ftsE
A6P53_09135	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
A6P53_09140	COG0653	protein targeting
A6P53_09155	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
A6P53_09160	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
A6P53_09170	COG1739	Uncharacterized protein family UPF0029
A6P53_09195	COG1940	carbohydrate kinase activity
A6P53_09205	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
A6P53_09210	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
A6P53_09235	COG0355	proton-transporting ATP synthase activity, rotational mechanism
A6P53_09240	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
A6P53_09245	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
A6P53_09250	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
A6P53_09255	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
A6P53_09260	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
A6P53_09265	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
A6P53_09270	COG0356	it plays a direct role in the translocation of protons across the membrane
A6P53_09275	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
A6P53_09280	COG0557	exoribonuclease II activity
A6P53_09290	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
A6P53_09295	COG2388	GCN5-related N-acetyl-transferase
A6P53_09330	COG0149	triose-phosphate isomerase activity
A6P53_09335	COG0126	phosphoglycerate kinase activity
A6P53_09350	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
A6P53_09370	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
A6P53_09375	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
A6P53_09380	COG1446	asparaginase
A6P53_09385	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
A6P53_09390	COG2188	Transcriptional regulator
A6P53_09420	COG1595	DNA-templated transcription, initiation
A6P53_09435	COG0095	Lipoate-protein ligase
A6P53_09440	COG1078	dGTPase activity
A6P53_09445	COG0561	phosphatase activity
A6P53_09450	COG0494	nUDIX hydrolase
A6P53_09455	COG0346	lactoylglutathione lyase activity
A6P53_09460	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
A6P53_09465	COG1394	ATPase activity, coupled to movement of substances
A6P53_09470	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
A6P53_09475	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
A6P53_09480	COG1436	Produces ATP from ADP in the presence of a proton gradient across the membrane
A6P53_09485	COG1527	subunit (C
A6P53_09490	COG1390	Produces ATP from ADP in the presence of a proton gradient across the membrane
A6P53_09495	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
A6P53_09500	COG1269	ATP hydrolysis coupled proton transport
A6P53_09510	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
A6P53_09515	COG1668	transmembrane transport
A6P53_09520	COG4152	abc transporter atp-binding protein
A6P53_09525	COG0322	excinuclease ABC activity
A6P53_09530	COG3118	belongs to the thioredoxin family
A6P53_09535	COG1193	negative regulation of DNA recombination
A6P53_09550	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
A6P53_09575	COG1136	(ABC) transporter
A6P53_09585	COG1304	FMN binding
A6P53_09595	COG2423	ornithine cyclodeaminase activity
A6P53_09600	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
A6P53_09630	COG0281	malic enzyme
A6P53_09650	COG1132	(ABC) transporter
A6P53_09675	COG3906	Belongs to the UPF0473 family
A6P53_09680	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
A6P53_09685	COG4472	Bacterial protein of unknown function (DUF965)
A6P53_09710	COG3689	TIGRFAM TIGR03943 family protein
A6P53_09715	COG0701	Predicted permease
A6P53_09720	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A6P53_09735	COG4467	Involved in initiation control of chromosome replication
A6P53_09740	COG1774	PSP1 C-terminal conserved region
A6P53_09745	COG0470	DNA polymerase III
A6P53_09750	COG3870	Protein conserved in bacteria
A6P53_09755	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
A6P53_09760	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
A6P53_09765	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
A6P53_09770	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
A6P53_09790	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
A6P53_09800	COG2814	Major facilitator Superfamily
A6P53_09810	COG1349	DNA-binding transcription factor activity
A6P53_09820	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A6P53_09820	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
A6P53_09835	COG0254	rRNA binding
A6P53_09840	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
A6P53_09845	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
A6P53_09855	COG0191	fructose-bisphosphate aldolase activity
A6P53_09860	COG0504	CTP synthase activity
A6P53_09875	COG0174	glutamine synthetase
A6P53_09880	COG0789	Transcriptional regulator
A6P53_09890	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
A6P53_09895	COG0584	glycerophosphoryl diester phosphodiesterase
A6P53_09905	COG0740	serine-type endopeptidase activity
A6P53_09910	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
A6P53_09920	COG1132	(ABC) transporter
A6P53_09940	COG1278	Cold shock
A6P53_09945	COG2003	Belongs to the UPF0758 family
A6P53_09950	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
A6P53_09955	COG0285	dihydrofolate synthase activity
A6P53_09960	COG0525	valine-tRNA ligase activity
A6P53_09970	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
A6P53_09975	COG0301	tRNA thio-modification
A6P53_09980	COG1104	cysteine desulfurase activity
A6P53_09985	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
A6P53_09995	COG0561	phosphatase activity
A6P53_10000	COG1801	Protein of unknown function DUF72
A6P53_10020	COG3579	cysteine-type endopeptidase activity
A6P53_10065	COG1098	S1 RNA binding domain
A6P53_10070	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
A6P53_10080	COG0492	ferredoxin-NADP+ reductase activity
A6P53_10085	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
A6P53_10100	COG4470	Protein conserved in bacteria
A6P53_10105	COG0737	Belongs to the 5'-nucleotidase family
A6P53_10125	COG0590	tRNA wobble adenosine to inosine editing
A6P53_10150	COG2738	Putative neutral zinc metallopeptidase
A6P53_10155	COG2824	Alkylphosphonate utilization operon protein PhnA
A6P53_10160	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
A6P53_10165	COG4109	DRTGG domain
A6P53_10170	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
A6P53_10185	COG3237	CsbD-like
A6P53_10190	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
A6P53_10195	COG1288	antiporter activity
A6P53_10200	COG4821	SIS domain
A6P53_10210	COG1210	Utp--glucose-1-phosphate uridylyltransferase
A6P53_10215	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
A6P53_10220	COG3469	chitinase activity
A6P53_10230	COG3397	chitin binding
A6P53_10235	COG3397	chitin binding
A6P53_10245	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
A6P53_10250	COG3716	PTS system mannose fructose sorbose family IID component
A6P53_10255	COG3715	PTS system
A6P53_10265	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
A6P53_10265	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A6P53_10270	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
A6P53_10270	COG3933	PFAM sigma-54 factor interaction domain-containing protein
A6P53_10275	COG1132	(ABC) transporter
A6P53_10280	COG1132	(ABC) transporter
A6P53_10310	COG1803	Methylglyoxal synthase
A6P53_10315	COG3842	ATPase activity
A6P53_10325	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
A6P53_10330	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
A6P53_10335	COG0084	hydrolase, TatD family'
A6P53_10340	COG0531	amino acid
A6P53_10355	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A6P53_10355	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A6P53_10445	COG1705	Flagellar rod assembly protein muramidase FlgJ
A6P53_10445	COG3942	CHAP domain
A6P53_10455	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
A6P53_10460	COG1134	teichoic acid transport
A6P53_10465	COG1682	transport, permease protein
A6P53_10495	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
A6P53_10505	COG0675	Transposase, IS605 OrfB family
A6P53_10510	COG4608	Belongs to the ABC transporter superfamily
A6P53_10515	COG0444	Belongs to the ABC transporter superfamily
A6P53_10520	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
A6P53_10525	COG0601	transmembrane transport
A6P53_10535	COG4166	transmembrane transport
A6P53_10545	COG0820	rRNA (adenine-C2-)-methyltransferase activity
A6P53_10550	COG1280	lysine exporter protein (LysE YggA)
A6P53_10550	COG1674	ftsk spoiiie
A6P53_10555	COG2723	6-phospho-beta-galactosidase activity
A6P53_10560	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
A6P53_10565	COG1126	abc transporter atp-binding protein
A6P53_10570	COG0765	amino acid transport
A6P53_10595	COG2814	Major facilitator Superfamily
A6P53_10600	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
A6P53_10605	COG0482	sulfurtransferase activity
A6P53_10655	COG1104	cysteine desulfurase activity
A6P53_10660	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
A6P53_10670	COG3590	peptidase
A6P53_10680	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
A6P53_10690	COG1335	isochorismatase
A6P53_10695	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
A6P53_10705	COG0494	nUDIX hydrolase
A6P53_10715	COG3853	Toxic anion resistance protein (TelA)
A6P53_10720	COG0531	amino acid
A6P53_10725	COG4975	Glucose uptake
A6P53_10730	COG0642	Histidine kinase
A6P53_10735	COG0745	RESPONSE REGULATOR receiver
A6P53_10745	COG0395	ABC-type sugar transport system, permease component
A6P53_10750	COG1175	transmembrane transport
A6P53_10760	COG3546	catalase activity
A6P53_10765	COG1764	response to oxidative stress
A6P53_10780	COG1438	arginine binding
A6P53_10790	COG0477	Major facilitator Superfamily
A6P53_10795	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
A6P53_10800	COG2823	Periplasmic or secreted lipoprotein
A6P53_10800	COG1652	LysM domain
A6P53_10805	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
A6P53_10820	COG1108	ABC-type Mn2 Zn2 transport systems permease components
A6P53_10825	COG1121	(ABC) transporter
A6P53_10830	COG1113	amino acid transport
A6P53_10840	COG2249	NAD(P)H dehydrogenase (quinone) activity
A6P53_10845	COG2207	Transcriptional regulator
A6P53_10860	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
A6P53_10880	COG4862	establishment of competence for transformation
A6P53_10885	COG1393	Belongs to the ArsC family
A6P53_10895	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
A6P53_10900	COG0419	ATPase involved in DNA repair
A6P53_10905	COG0420	3'-5' exonuclease activity
A6P53_10910	COG0204	Acyl-transferase
A6P53_10915	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
A6P53_10920	COG2827	Endonuclease containing a URI domain
A6P53_10930	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
A6P53_10935	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
A6P53_10940	COG0124	histidyl-tRNA synthetase
A6P53_10945	COG0667	Aldo Keto reductase
A6P53_10950	COG2124	cytochrome p450
A6P53_10955	COG1490	D-aminoacyl-tRNA deacylase activity
A6P53_10960	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
A6P53_10965	COG1385	rRNA (uridine-N3-)-methyltransferase activity
A6P53_10970	COG2264	protein methyltransferase activity
A6P53_10980	COG2094	Belongs to the DNA glycosylase MPG family
A6P53_10990	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
A6P53_11005	COG0589	response to stress
A6P53_11025	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
A6P53_11030	COG0827	DNA restriction-modification system
A6P53_11055	COG4537	Required for transformation and DNA binding
A6P53_11060	COG1459	type II secretion system
A6P53_11065	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
A6P53_11075	COG0220	tRNA (guanine-N7-)-methyltransferase activity
A6P53_11085	COG4473	ABC transporter
A6P53_11090	COG1131	(ABC) transporter
A6P53_11095	COG0537	adenosine 5'-monophosphoramidase activity
A6P53_11105	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
A6P53_11115	COG3481	metal-dependent phosphohydrolase, HD sub domain
A6P53_11120	COG4717	serine-type aminopeptidase activity
A6P53_11150	COG3679	Belongs to the UPF0342 family
A6P53_11155	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
A6P53_11160	COG0564	pseudouridine synthase activity
A6P53_11170	COG0383	alpha-mannosidase activity
A6P53_11195	COG0477	Major facilitator Superfamily
A6P53_11205	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
A6P53_11215	COG3835	regulator
A6P53_11225	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
A6P53_11235	COG2723	6-phospho-beta-galactosidase activity
A6P53_11245	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
A6P53_11245	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
A6P53_11290	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
A6P53_11315	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
A6P53_11320	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
A6P53_11325	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A6P53_11345	COG3716	PTS system mannose fructose sorbose family IID component
A6P53_11350	COG3715	PTS system
A6P53_11355	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
A6P53_11360	COG2188	Transcriptional regulator
A6P53_11365	COG0589	response to stress
A6P53_11370	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
A6P53_11375	COG1363	Peptidase, m42
A6P53_11395	COG0053	Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family
A6P53_11405	COG1215	transferase activity, transferring glycosyl groups
A6P53_11415	COG3973	AAA domain
A6P53_11420	COG0446	pyridine nucleotide-disulphide oxidoreductase
A6P53_11425	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
A6P53_11430	COG1937	Protein conserved in bacteria
A6P53_11440	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
A6P53_11445	COG1193	negative regulation of DNA recombination
A6P53_11450	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
A6P53_11455	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
A6P53_11460	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
A6P53_11470	COG0446	pyridine nucleotide-disulphide oxidoreductase
A6P53_11495	COG1902	pentaerythritol trinitrate reductase activity
A6P53_11500	COG1846	Transcriptional regulator
A6P53_11520	COG0366	Alpha amylase catalytic
A6P53_11525	COG2252	PERMEase
A6P53_11540	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
A6P53_11540	COG0072	phenylalanine-tRNA ligase activity
A6P53_11550	COG1846	Transcriptional regulator
A6P53_11555	COG1051	belongs to the nudix hydrolase family
A6P53_11565	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
A6P53_11570	COG1113	amino acid transport
A6P53_11575	COG1113	amino acid transport
A6P53_11605	COG3512	CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette
A6P53_11610	COG1518	maintenance of DNA repeat elements
A6P53_11615	COG3513	CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). In type II CRISPR systems correct processing of pre-crRNA requires a trans-encoded small RNA (tracrRNA), endogenous ribonuclease 3 (rnc) and this protein. The tracrRNA serves as a guide for ribonuclease 3-aided processing of pre-crRNA. Subsequently Cas9 crRNA tracrRNA endonucleolytically cleaves linear or circular dsDNA target complementary to the spacer
A6P53_11625	COG4716	Myosin-crossreactive antigen
A6P53_11635	COG1063	alcohol dehydrogenase
A6P53_11650	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
A6P53_11655	COG1447	Phosphotransferase system cellobiose-specific component IIA
A6P53_11660	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
A6P53_11670	COG0667	Aldo Keto reductase
A6P53_11680	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
A6P53_11695	COG2207	Transcriptional regulator
A6P53_11695	COG4753	response regulator
A6P53_11700	COG2972	Histidine kinase
A6P53_11715	COG0395	ABC-type sugar transport system, permease component
A6P53_11725	COG1187	pseudouridine synthase activity
A6P53_11730	COG2244	polysaccharide biosynthetic process
A6P53_11740	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
A6P53_11745	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
A6P53_11755	COG1447	Phosphotransferase system cellobiose-specific component IIA
A6P53_11760	COG3711	transcriptional antiterminator
A6P53_11760	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
A6P53_11775	COG0495	leucyl-tRNA aminoacylation
A6P53_11780	COG1388	LysM domain
A6P53_11780	COG1705	Flagellar rod assembly protein muramidase FlgJ
A6P53_11785	COG0671	phosphoesterase, PA-phosphatase related
A6P53_11790	COG1242	4 iron, 4 sulfur cluster binding
A6P53_11795	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
A6P53_11820	COG1132	(ABC) transporter
A6P53_11825	COG1132	(ABC) transporter
A6P53_11835	COG1607	acyl-coa hydrolase
A6P53_11845	COG0477	Major facilitator Superfamily
A6P53_11850	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
A6P53_12000	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
A6P53_12005	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
A6P53_12010	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
A6P53_12015	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
A6P53_12025	COG0037	tRNA processing
A6P53_12030	COG1098	S1 RNA binding domain
A6P53_12040	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
A6P53_12045	COG2244	polysaccharide biosynthetic process
A6P53_12050	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
A6P53_12055	COG0193	aminoacyl-tRNA hydrolase activity
A6P53_12060	COG0039	L-malate dehydrogenase activity
A6P53_12095	COG1792	Involved in formation and maintenance of cell shape
A6P53_12105	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
A6P53_12110	COG1162	GTPase activity
A6P53_12115	COG0515	serine threonine protein kinase
A6P53_12115	COG2815	serine threonine protein kinase
A6P53_12120	COG0631	protein serine/threonine phosphatase activity
A6P53_12125	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
A6P53_12125	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
A6P53_12130	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
A6P53_12135	COG0242	peptide deformylase activity
A6P53_12140	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
A6P53_12145	COG1758	RNA polymerase activity
A6P53_12150	COG0194	GDP metabolic process
A6P53_12160	COG1561	YicC-like family, N-terminal region
A6P53_12185	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
A6P53_12190	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
A6P53_12195	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
A6P53_12200	COG1108	ABC-type Mn2 Zn2 transport systems permease components
A6P53_12205	COG1121	(ABC) transporter
A6P53_12210	COG0803	Belongs to the bacterial solute-binding protein 9 family
A6P53_12210	COG3443	Belongs to the bacterial solute-binding protein 9 family
A6P53_12215	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
A6P53_12220	COG0392	lysyltransferase activity
A6P53_12220	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
A6P53_12225	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
A6P53_12235	COG1418	mRNA catabolic process
A6P53_12240	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
A6P53_12245	COG1546	Belongs to the CinA family
A6P53_12245	COG1058	Belongs to the CinA family
A6P53_12250	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
A6P53_12255	COG1426	Protein conserved in bacteria
A6P53_12260	COG0612	Peptidase, M16
A6P53_12265	COG0612	Peptidase, M16
A6P53_12270	COG1970	mechanosensitive ion channel activity
A6P53_12275	COG2153	protein acetylation
A6P53_12280	COG4466	Protein conserved in bacteria
A6P53_12290	COG3688	RNA-binding protein containing a PIN domain
A6P53_12300	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
A6P53_12305	COG0215	cysteine-tRNA ligase activity
A6P53_12310	COG1045	serine acetyltransferase
A6P53_12315	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
A6P53_12320	COG4956	integral membrane protein (PIN domain superfamily)
A6P53_12330	COG0756	dUTP diphosphatase activity
A6P53_12335	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
A6P53_12340	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
A6P53_12355	COG2814	Major facilitator Superfamily
A6P53_12370	COG0702	epimerase
A6P53_12375	COG1959	2 iron, 2 sulfur cluster binding
A6P53_12385	COG1674	ftsk spoiiie
A6P53_12400	COG4842	Belongs to the WXG100 family
A6P53_12405	COG1562	ergosterol biosynthetic process
A6P53_12410	COG1233	COG1233 Phytoene dehydrogenase and related
A6P53_12415	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
A6P53_12425	COG0842	Transport permease protein
A6P53_12430	COG1131	(ABC) transporter
A6P53_12445	COG2723	6-phospho-beta-galactosidase activity
A6P53_12455	COG1131	(ABC) transporter
A6P53_12465	COG4585	Histidine kinase
A6P53_12490	COG3414	Phosphotransferase system galactitol-specific IIB component
A6P53_12495	COG3775	system Galactitol-specific IIC component
A6P53_12500	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
A6P53_12505	COG3711	transcriptional antiterminator
A6P53_12505	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
A6P53_12510	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
A6P53_12530	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
A6P53_12535	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
A6P53_12540	COG0783	Belongs to the Dps family
A6P53_12545	COG1070	Carbohydrate kinase
A6P53_12550	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
A6P53_12555	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
A6P53_12565	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
A6P53_12585	COG4120	Belongs to the binding-protein-dependent transport system permease family
A6P53_12595	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
A6P53_12595	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
A6P53_12605	COG0142	geranyltranstransferase activity
A6P53_12625	COG4939	FMN-binding domain protein
A6P53_12700	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
A6P53_12715	COG0542	response to heat
A6P53_12720	COG4463	regulation of RNA biosynthetic process
A6P53_12795	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
A6P53_12800	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
A6P53_12815	COG0012	GTP binding
A6P53_12820	COG4481	Protein conserved in bacteria
A6P53_12825	COG1475	DNA binding
A6P53_12830	COG1192	Involved in chromosome partitioning
A6P53_12835	COG0357	Ribosomal RNA small subunit methyltransferase G
A6P53_12845	COG0445	tRNA wobble uridine modification
A6P53_12850	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
A6P53_12860	COG1847	R3H domain protein
A6P53_12865	COG0706	membrane insertase activity
A6P53_12870	COG0594	ribonuclease P activity
A6P53_12875	COG0230	Belongs to the bacterial ribosomal protein bL34 family
A6P53_12955	COG1192	Involved in chromosome partitioning
A6P53_12990	COG3316	Transposase and inactivated derivatives
A6P53_13000	COG0791	NLP P60 protein
A6P53_13000	COG0741	lytic transglycosylase activity
A6P53_13025	COG3316	Transposase and inactivated derivatives
A6P53_13040	COG3316	Transposase and inactivated derivatives
A6P53_13070	COG3316	Transposase and inactivated derivatives
A6P53_13080	COG0629	single-stranded DNA binding