locus-tag	class	description
I4Q40_00005	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
I4Q40_00010	COG0592	DNA-directed DNA polymerase activity
I4Q40_00015	COG2501	S4 domain
I4Q40_00020	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
I4Q40_00025	COG0187	DNA topoisomerase II activity
I4Q40_00035	COG0360	Binds together with S18 to 16S ribosomal RNA
I4Q40_00040	COG0629	single-stranded DNA binding
I4Q40_00045	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
I4Q40_00055	COG0359	binds to the 23S rRNA
I4Q40_00060	COG0305	Participates in initiation and elongation during chromosome replication
I4Q40_00065	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
I4Q40_00075	COG0488	(ABC) transporter
I4Q40_00085	COG0028	Belongs to the TPP enzyme family
I4Q40_00115	COG4166	transmembrane transport
I4Q40_00120	COG0601	transmembrane transport
I4Q40_00125	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I4Q40_00130	COG0444	Belongs to the ABC transporter superfamily
I4Q40_00135	COG4608	Belongs to the ABC transporter superfamily
I4Q40_00175	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I4Q40_00175	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I4Q40_00185	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
I4Q40_00185	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
I4Q40_00190	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
I4Q40_00210	COG0519	Catalyzes the synthesis of GMP from XMP
I4Q40_00210	COG0518	GMP synthase (glutamine-hydrolyzing) activity
I4Q40_00215	COG1072	(Pantothenic acid kinase))
I4Q40_00220	COG2813	Specifically methylates the guanine in position
I4Q40_00225	COG1609	Transcriptional regulator
I4Q40_00230	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
I4Q40_00235	COG0274	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate
I4Q40_00240	COG0295	cytidine deaminase activity
I4Q40_00245	COG1744	ABC transporter substrate-binding protein PnrA-like
I4Q40_00250	COG3845	ABC transporter
I4Q40_00255	COG4603	Belongs to the binding-protein-dependent transport system permease family
I4Q40_00260	COG1079	Belongs to the binding-protein-dependent transport system permease family
I4Q40_00265	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
I4Q40_00285	COG0588	phosphoglycerate mutase activity
I4Q40_00295	COG0120	Catalyzes the reversible conversion of ribose-5- phosphate to ribulose 5-phosphate
I4Q40_00300	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
I4Q40_00305	COG0049	tRNA binding
I4Q40_00310	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
I4Q40_00315	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
I4Q40_00320	COG0051	transcription antitermination factor activity, RNA binding
I4Q40_00325	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
I4Q40_00330	COG0088	Forms part of the polypeptide exit tunnel
I4Q40_00335	COG0089	rRNA binding
I4Q40_00340	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
I4Q40_00350	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
I4Q40_00355	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
I4Q40_00360	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
I4Q40_00365	COG0255	Belongs to the universal ribosomal protein uL29 family
I4Q40_00370	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
I4Q40_00375	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
I4Q40_00380	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
I4Q40_00385	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
I4Q40_00390	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
I4Q40_00395	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
I4Q40_00400	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
I4Q40_00405	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
I4Q40_00410	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
I4Q40_00415	COG1841	ribosomal large subunit assembly
I4Q40_00420	COG0200	Binds to the 23S rRNA
I4Q40_00425	COG0201	protein transport
I4Q40_00430	COG0563	adenylate kinase activity
I4Q40_00435	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
I4Q40_00440	COG0257	Belongs to the bacterial ribosomal protein bL36 family
I4Q40_00445	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
I4Q40_00450	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
I4Q40_00455	COG0202	RNA polymerase activity
I4Q40_00460	COG0203	ribosomal protein L17
I4Q40_00465	COG1122	ATPase activity
I4Q40_00470	COG1122	ATPase activity
I4Q40_00480	COG0101	tRNA pseudouridine synthase activity
I4Q40_00495	COG0227	Belongs to the bacterial ribosomal protein bL28 family
I4Q40_00505	COG1461	Dihydroxyacetone kinase
I4Q40_00510	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
I4Q40_00515	COG0416	fatty acid biosynthetic process
I4Q40_00520	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I4Q40_00530	COG4608	Belongs to the ABC transporter superfamily
I4Q40_00535	COG0601	transmembrane transport
I4Q40_00540	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I4Q40_00555	COG1136	(ABC) transporter
I4Q40_00555	COG0577	efflux transmembrane transporter activity
I4Q40_00560	COG0571	ribonuclease III activity
I4Q40_00565	COG1196	nuclear chromosome segregation
I4Q40_00570	COG0561	phosphatase activity
I4Q40_00575	COG0552	protein localization to endoplasmic reticulum
I4Q40_00580	COG2918	glutathione biosynthetic process
I4Q40_00580	COG1181	Belongs to the D-alanine--D-alanine ligase family
I4Q40_00590	COG4606	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I4Q40_00595	COG4605	iron ion homeostasis
I4Q40_00600	COG4604	ABC transporter, ATP-binding protein
I4Q40_00605	COG4607	ABC-type enterochelin transport system periplasmic component
I4Q40_00630	COG1349	DNA-binding transcription factor activity
I4Q40_00635	COG1447	Phosphotransferase system cellobiose-specific component IIA
I4Q40_00645	COG2723	6-phospho-beta-galactosidase activity
I4Q40_00660	COG1105	Belongs to the carbohydrate kinase PfkB family
I4Q40_00665	COG3684	Belongs to the aldolase LacD family
I4Q40_00695	COG1380	Effector of murein hydrolase LrgA
I4Q40_00715	COG1028	Short-chain dehydrogenase reductase Sdr
I4Q40_00725	COG1268	BioY protein
I4Q40_00730	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
I4Q40_00745	COG0561	phosphatase activity
I4Q40_00755	COG1692	metallophosphoesterase
I4Q40_00765	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
I4Q40_00775	COG0424	maF-like protein
I4Q40_00780	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I4Q40_00780	COG1263	PTS System
I4Q40_00785	COG2188	Transcriptional regulator
I4Q40_00795	COG0632	four-way junction helicase activity
I4Q40_00800	COG2255	four-way junction helicase activity
I4Q40_00810	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I4Q40_00830	COG1114	Component of the transport system for branched-chain amino acids
I4Q40_00840	COG1113	amino acid transport
I4Q40_00845	COG1126	abc transporter atp-binding protein
I4Q40_00850	COG0765	amino acid transport
I4Q40_00860	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
I4Q40_00865	COG0110	maltose O-acetyltransferase activity
I4Q40_00870	COG1827	regulation of RNA biosynthetic process
I4Q40_00880	COG0242	peptide deformylase activity
I4Q40_00885	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
I4Q40_00890	COG1185	polyribonucleotide nucleotidyltransferase activity
I4Q40_00900	COG3158	transport of potassium into the cell
I4Q40_00905	COG1253	flavin adenine dinucleotide binding
I4Q40_00910	COG0534	Mate efflux family protein
I4Q40_00920	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
I4Q40_00925	COG1187	pseudouridine synthase activity
I4Q40_00930	COG1011	Hydrolase
I4Q40_00935	COG0572	uridine kinase
I4Q40_00955	COG1671	Belongs to the UPF0178 family
I4Q40_00965	COG1181	Belongs to the D-alanine--D-alanine ligase family
I4Q40_00970	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
I4Q40_00980	COG0736	holo-[acyl-carrier-protein] synthase activity
I4Q40_00985	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
I4Q40_00990	COG2337	Toxic component of a toxin-antitoxin (TA) module
I4Q40_00995	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
I4Q40_01000	COG0604	alcohol dehydrogenase
I4Q40_01000	COG3321	synthase
I4Q40_01010	COG0531	amino acid
I4Q40_01025	COG1175	transmembrane transport
I4Q40_01030	COG0395	ABC-type sugar transport system, permease component
I4Q40_01040	COG3940	Belongs to the glycosyl hydrolase 43 family
I4Q40_01045	COG3507	Belongs to the glycosyl hydrolase 43 family
I4Q40_01050	COG3534	alpha-L-arabinofuranosidase
I4Q40_01060	COG3507	Belongs to the glycosyl hydrolase 43 family
I4Q40_01090	COG1174	glycine betaine transport
I4Q40_01115	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
I4Q40_01130	COG0343	queuine tRNA-ribosyltransferase activity
I4Q40_01135	COG1862	Preprotein translocase
I4Q40_01140	COG1012	belongs to the aldehyde dehydrogenase family
I4Q40_01140	COG1454	alcohol dehydrogenase
I4Q40_01145	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
I4Q40_01175	COG2207	Transcriptional regulator
I4Q40_01175	COG1917	Cupin 2, conserved barrel domain protein
I4Q40_01180	COG1070	Carbohydrate kinase
I4Q40_01185	COG4806	L-rhamnose isomerase
I4Q40_01190	COG0235	Class ii aldolase
I4Q40_01195	COG3254	rhamnose metabolic process
I4Q40_01200	COG1454	alcohol dehydrogenase
I4Q40_01205	COG1414	Transcriptional regulator
I4Q40_01210	COG0800	Aldolase
I4Q40_01220	COG3717	Catalyzes the isomerization of 5-dehydro-4-deoxy-D- glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
I4Q40_01225	COG1028	Short-chain dehydrogenase reductase Sdr
I4Q40_01230	COG1304	FMN binding
I4Q40_01245	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
I4Q40_01250	COG1428	Deoxynucleoside kinase
I4Q40_01265	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
I4Q40_01270	COG0291	Belongs to the bacterial ribosomal protein bL35 family
I4Q40_01275	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
I4Q40_01315	COG0824	Thioesterase
I4Q40_01320	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
I4Q40_01340	COG1363	Peptidase, m42
I4Q40_01345	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I4Q40_01350	COG0589	response to stress
I4Q40_01355	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I4Q40_01360	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I4Q40_01365	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
I4Q40_01420	COG2184	nucleotidyltransferase activity
I4Q40_01450	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
I4Q40_01480	COG3328	transposase activity
I4Q40_01495	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I4Q40_01500	COG3414	Phosphotransferase system galactitol-specific IIB component
I4Q40_01505	COG3775	system Galactitol-specific IIC component
I4Q40_01530	COG1105	Belongs to the carbohydrate kinase PfkB family
I4Q40_01535	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I4Q40_01535	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I4Q40_01535	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I4Q40_01540	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I4Q40_01540	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I4Q40_01540	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I4Q40_01545	COG3684	Belongs to the aldolase LacD family
I4Q40_01560	COG2188	Transcriptional regulator
I4Q40_01585	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
I4Q40_01600	COG1764	response to oxidative stress
I4Q40_01615	COG1940	carbohydrate kinase activity
I4Q40_01635	COG0366	Alpha amylase catalytic
I4Q40_01665	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
I4Q40_01675	COG3711	transcriptional antiterminator
I4Q40_01675	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I4Q40_01695	COG4821	SIS domain
I4Q40_01700	COG0101	tRNA pseudouridine synthase activity
I4Q40_01710	COG0667	Aldo Keto reductase
I4Q40_01715	COG2186	Transcriptional regulator
I4Q40_01720	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I4Q40_01725	COG2723	6-phospho-beta-galactosidase activity
I4Q40_01735	COG1447	Phosphotransferase system cellobiose-specific component IIA
I4Q40_01740	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I4Q40_01755	COG1063	alcohol dehydrogenase
I4Q40_01765	COG4716	Myosin-crossreactive antigen
I4Q40_01800	COG1113	amino acid transport
I4Q40_01835	COG3052	prosthetic group binding
I4Q40_01905	COG1051	belongs to the nudix hydrolase family
I4Q40_01910	COG1846	Transcriptional regulator
I4Q40_01935	COG2252	PERMEase
I4Q40_01940	COG0366	Alpha amylase catalytic
I4Q40_01950	COG1902	pentaerythritol trinitrate reductase activity
I4Q40_01960	COG0446	pyridine nucleotide-disulphide oxidoreductase
I4Q40_01975	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
I4Q40_01980	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
I4Q40_01985	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
I4Q40_01990	COG1193	negative regulation of DNA recombination
I4Q40_01995	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
I4Q40_02005	COG1937	Protein conserved in bacteria
I4Q40_02010	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I4Q40_02015	COG0446	pyridine nucleotide-disulphide oxidoreductase
I4Q40_02020	COG3973	AAA domain
I4Q40_02045	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
I4Q40_02050	COG2376	Dihydroxyacetone kinase
I4Q40_02055	COG1461	Dihydroxyacetone kinase
I4Q40_02090	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I4Q40_02095	COG3559	Exporter of polyketide antibiotics
I4Q40_02100	COG1131	(ABC) transporter
I4Q40_02105	COG1309	transcriptional regulator
I4Q40_02125	COG0531	amino acid
I4Q40_02130	COG1757	Na H antiporter
I4Q40_02150	COG1609	Transcriptional regulator
I4Q40_02160	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I4Q40_02170	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I4Q40_02170	COG2190	(PTS) system
I4Q40_02170	COG1263	PTS System
I4Q40_02200	COG3479	Phenolic acid decarboxylase
I4Q40_02205	COG1695	Transcriptional regulator
I4Q40_02215	COG2814	Major facilitator Superfamily
I4Q40_02235	COG0163	prenyltransferase activity
I4Q40_02240	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
I4Q40_02250	COG0577	efflux transmembrane transporter activity
I4Q40_02250	COG1136	(ABC) transporter
I4Q40_02250	COG0577	efflux transmembrane transporter activity
I4Q40_02250	COG1136	(ABC) transporter
I4Q40_02270	COG1811	Na channel or pump
I4Q40_02305	COG1136	(ABC) transporter
I4Q40_02320	COG3942	CHAP domain
I4Q40_02320	COG1705	Flagellar rod assembly protein muramidase FlgJ
I4Q40_02325	COG2190	(PTS) system
I4Q40_02325	COG1263	PTS System
I4Q40_02325	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I4Q40_02330	COG1869	D-ribose catabolic process
I4Q40_02340	COG1609	Transcriptional regulator
I4Q40_02360	COG0366	Alpha amylase catalytic
I4Q40_02365	COG0628	permease
I4Q40_02370	COG0803	Belongs to the bacterial solute-binding protein 9 family
I4Q40_02370	COG3443	Belongs to the bacterial solute-binding protein 9 family
I4Q40_02395	COG1428	Deoxynucleoside kinase
I4Q40_02405	COG0210	DNA helicase
I4Q40_02410	COG1393	Belongs to the ArsC family
I4Q40_02415	COG1393	Belongs to the ArsC family
I4Q40_02435	COG0386	Belongs to the glutathione peroxidase family
I4Q40_02440	COG1854	S-ribosylhomocysteine lyase activity
I4Q40_02445	COG0626	cystathionine gamma-synthase activity
I4Q40_02450	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I4Q40_02455	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
I4Q40_02460	COG0484	heat shock protein binding
I4Q40_02465	COG2015	COG2015, Alkyl sulfatase and related hydrolases
I4Q40_02470	COG0019	diaminopimelate decarboxylase activity
I4Q40_02475	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
I4Q40_02485	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
I4Q40_02490	COG2171	N-acyltransferase activity
I4Q40_02495	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
I4Q40_02500	COG0527	aspartate kinase activity
I4Q40_02505	COG1473	amidohydrolase
I4Q40_02510	COG0436	Aminotransferase
I4Q40_02515	COG0446	pyridine nucleotide-disulphide oxidoreductase
I4Q40_02530	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I4Q40_02535	COG0153	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)
I4Q40_02550	COG2207	Transcriptional regulator
I4Q40_02555	COG2249	NAD(P)H dehydrogenase (quinone) activity
I4Q40_02570	COG1113	amino acid transport
I4Q40_02575	COG1121	(ABC) transporter
I4Q40_02580	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I4Q40_02595	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
I4Q40_02600	COG1652	LysM domain
I4Q40_02600	COG2823	Periplasmic or secreted lipoprotein
I4Q40_02610	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I4Q40_02615	COG0477	Major facilitator Superfamily
I4Q40_02625	COG1438	arginine binding
I4Q40_02640	COG1764	response to oxidative stress
I4Q40_02645	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I4Q40_02650	COG1335	isochorismatase
I4Q40_02660	COG2135	peptidase activity
I4Q40_02675	COG3546	catalase activity
I4Q40_02685	COG1175	transmembrane transport
I4Q40_02690	COG0395	ABC-type sugar transport system, permease component
I4Q40_02700	COG0671	phosphoesterase, PA-phosphatase related
I4Q40_02725	COG0745	RESPONSE REGULATOR receiver
I4Q40_02730	COG5002	protein histidine kinase activity
I4Q40_02735	COG4975	Glucose uptake
I4Q40_02740	COG0531	amino acid
I4Q40_02745	COG3853	Toxic anion resistance protein (TelA)
I4Q40_02765	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
I4Q40_02770	COG1335	isochorismatase
I4Q40_02780	COG3590	peptidase
I4Q40_02790	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
I4Q40_02795	COG1104	cysteine desulfurase activity
I4Q40_02835	COG0482	sulfurtransferase activity
I4Q40_02845	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
I4Q40_02850	COG2814	Major facilitator Superfamily
I4Q40_02870	COG0463	Glycosyl transferase, family 2
I4Q40_02875	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I4Q40_02880	COG2855	membrane
I4Q40_02890	COG0583	DNA-binding transcription factor activity
I4Q40_02895	COG0772	Belongs to the SEDS family
I4Q40_02900	COG1393	Belongs to the ArsC family
I4Q40_02905	COG0509	glycine decarboxylation via glycine cleavage system
I4Q40_02910	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
I4Q40_02915	COG2011	ABC-type metal ion transport system permease component
I4Q40_02920	COG1464	Belongs to the NlpA lipoprotein family
I4Q40_02930	COG0719	Fe-S assembly protein
I4Q40_02935	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
I4Q40_02945	COG0719	Fe-S assembly protein
I4Q40_03050	COG1136	(ABC) transporter
I4Q40_03050	COG0577	efflux transmembrane transporter activity
I4Q40_03055	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I4Q40_03065	COG1597	lipid kinase activity
I4Q40_03100	COG1733	regulation of RNA biosynthetic process
I4Q40_03115	COG3764	Sortase (surface protein transpeptidase)
I4Q40_03120	COG3711	transcriptional antiterminator
I4Q40_03130	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I4Q40_03130	COG2190	(PTS) system
I4Q40_03130	COG1263	PTS System
I4Q40_03135	COG2723	6-phospho-beta-galactosidase activity
I4Q40_03140	COG2188	Transcriptional regulator
I4Q40_03150	COG1611	Belongs to the LOG family
I4Q40_03160	COG1428	Deoxynucleoside kinase
I4Q40_03170	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I4Q40_03175	COG1472	Belongs to the glycosyl hydrolase 3 family
I4Q40_03185	COG2723	6-phospho-beta-galactosidase activity
I4Q40_03195	COG1368	sulfuric ester hydrolase activity
I4Q40_03205	COG0105	UTP biosynthetic process
I4Q40_03210	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
I4Q40_03220	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
I4Q40_03225	COG2011	ABC-type metal ion transport system permease component
I4Q40_03230	COG1464	Belongs to the NlpA lipoprotein family
I4Q40_03235	COG1473	amidohydrolase
I4Q40_03240	COG1757	Na H antiporter
I4Q40_03250	COG1113	amino acid transport
I4Q40_03260	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
I4Q40_03265	COG1929	Belongs to the glycerate kinase type-1 family
I4Q40_03270	COG0488	(ABC) transporter
I4Q40_03285	COG2103	Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate
I4Q40_03290	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I4Q40_03290	COG1263	PTS System
I4Q40_03300	COG1780	Probably involved in ribonucleotide reductase function
I4Q40_03310	COG1277	ABC-type transport system involved in multi-copper enzyme maturation permease component
I4Q40_03315	COG1131	(ABC) transporter
I4Q40_03335	COG1136	(ABC) transporter
I4Q40_03350	COG2039	Removes 5-oxoproline from various penultimate amino acid residues except L-proline
I4Q40_03365	COG0346	lactoylglutathione lyase activity
I4Q40_03390	COG0561	phosphatase activity
I4Q40_03395	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
I4Q40_03400	COG0280	phosphate acetyltransferase
I4Q40_03405	COG0802	atpase or kinase
I4Q40_03410	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I4Q40_03420	COG0708	Exodeoxyribonuclease III
I4Q40_03430	COG0812	UDP-N-acetylmuramate dehydrogenase activity
I4Q40_03455	COG1053	succinate dehydrogenase
I4Q40_03460	COG0604	alcohol dehydrogenase
I4Q40_03460	COG1028	Short-chain dehydrogenase reductase Sdr
I4Q40_03460	COG3321	synthase
I4Q40_03465	COG0702	epimerase
I4Q40_03470	COG4684	Psort location CytoplasmicMembrane, score
I4Q40_03475	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
I4Q40_03480	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
I4Q40_03485	COG0604	alcohol dehydrogenase
I4Q40_03495	COG3842	ATPase activity
I4Q40_03500	COG1176	ABC-type spermidine putrescine transport system, permease component I
I4Q40_03505	COG1177	transmembrane transport
I4Q40_03510	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
I4Q40_03530	COG1121	(ABC) transporter
I4Q40_03545	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
I4Q40_03550	COG0446	pyridine nucleotide-disulphide oxidoreductase
I4Q40_03555	COG0488	(ABC) transporter
I4Q40_03560	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
I4Q40_03570	COG0701	Predicted permease
I4Q40_03575	COG3689	TIGRFAM TIGR03943 family protein
I4Q40_03605	COG4472	Bacterial protein of unknown function (DUF965)
I4Q40_03610	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
I4Q40_03615	COG3906	Belongs to the UPF0473 family
I4Q40_03635	COG0281	malic enzyme
I4Q40_03645	COG1304	FMN binding
I4Q40_03680	COG0446	pyridine nucleotide-disulphide oxidoreductase
I4Q40_03690	COG1136	(ABC) transporter
I4Q40_03705	COG1039	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
I4Q40_03720	COG1193	negative regulation of DNA recombination
I4Q40_03725	COG3118	belongs to the thioredoxin family
I4Q40_03730	COG0322	excinuclease ABC activity
I4Q40_03735	COG4152	abc transporter atp-binding protein
I4Q40_03745	COG3855	fructose 1,6-bisphosphate 1-phosphatase activity
I4Q40_03750	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
I4Q40_03760	COG1269	ATP hydrolysis coupled proton transport
I4Q40_03765	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
I4Q40_03770	COG1390	Produces ATP from ADP in the presence of a proton gradient across the membrane
I4Q40_03775	COG1527	subunit (C
I4Q40_03780	COG1436	Produces ATP from ADP in the presence of a proton gradient across the membrane
I4Q40_03785	COG1155	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit
I4Q40_03790	COG1156	Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit
I4Q40_03795	COG1394	ATPase activity, coupled to movement of substances
I4Q40_03800	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
I4Q40_03805	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I4Q40_03810	COG2423	ornithine cyclodeaminase activity
I4Q40_03820	COG0346	lactoylglutathione lyase activity
I4Q40_03825	COG0494	nUDIX hydrolase
I4Q40_03830	COG0561	phosphatase activity
I4Q40_03835	COG1078	dGTPase activity
I4Q40_03840	COG0095	Lipoate-protein ligase
I4Q40_03855	COG1595	DNA-templated transcription, initiation
I4Q40_03875	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
I4Q40_03880	COG2390	Transcriptional regulator
I4Q40_03890	COG0126	phosphoglycerate kinase activity
I4Q40_03895	COG0149	triose-phosphate isomerase activity
I4Q40_03915	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I4Q40_03935	COG2388	GCN5-related N-acetyl-transferase
I4Q40_03940	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
I4Q40_03950	COG0557	exoribonuclease II activity
I4Q40_03955	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
I4Q40_03960	COG0356	it plays a direct role in the translocation of protons across the membrane
I4Q40_03965	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
I4Q40_03970	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
I4Q40_03975	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
I4Q40_03980	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
I4Q40_03985	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
I4Q40_03990	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
I4Q40_03995	COG0355	proton-transporting ATP synthase activity, rotational mechanism
I4Q40_04005	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
I4Q40_04025	COG1940	carbohydrate kinase activity
I4Q40_04050	COG2188	Transcriptional regulator
I4Q40_04055	COG1739	Uncharacterized protein family UPF0029
I4Q40_04065	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I4Q40_04070	COG4098	Superfamily II DNA RNA helicase required for DNA uptake (late competence protein)
I4Q40_04085	COG0653	protein targeting
I4Q40_04095	COG2884	Cell division ATP-binding protein ftsE
I4Q40_04100	COG2177	Part of the ABC transporter FtsEX involved in
I4Q40_04105	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I4Q40_04110	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
I4Q40_04115	COG0573	inorganic phosphate transmembrane transporter activity
I4Q40_04120	COG0581	inorganic phosphate transmembrane transporter activity
I4Q40_04125	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
I4Q40_04130	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
I4Q40_04135	COG0704	Plays a role in the regulation of phosphate uptake
I4Q40_04160	COG1950	PFAM Membrane protein of
I4Q40_04165	COG1493	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion
I4Q40_04170	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
I4Q40_04175	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
I4Q40_04180	COG1210	Utp--glucose-1-phosphate uridylyltransferase
I4Q40_04190	COG4980	gas vesicle protein
I4Q40_04195	COG0006	proline dipeptidase activity
I4Q40_04200	COG1609	Transcriptional regulator
I4Q40_04250	COG0648	Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin
I4Q40_04260	COG1914	H( )-stimulated, divalent metal cation uptake system
I4Q40_04265	COG3763	UPF0154 protein
I4Q40_04270	COG1132	(ABC) transporter
I4Q40_04275	COG1132	(ABC) transporter
I4Q40_04280	COG3711	transcriptional antiterminator
I4Q40_04285	COG2190	(PTS) system
I4Q40_04285	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I4Q40_04285	COG1263	PTS System
I4Q40_04290	COG1737	Transcriptional regulator
I4Q40_04295	COG1486	melibiose metabolic process
I4Q40_04300	COG2723	6-phospho-beta-galactosidase activity
I4Q40_04305	COG0492	ferredoxin-NADP+ reductase activity
I4Q40_04310	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I4Q40_04315	COG0640	Transcriptional regulator
I4Q40_04320	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
I4Q40_04325	COG0735	belongs to the Fur family
I4Q40_04330	COG0828	Belongs to the bacterial ribosomal protein bS21 family
I4Q40_04335	COG1610	YqeY-like protein
I4Q40_04340	COG1114	Component of the transport system for branched-chain amino acids
I4Q40_04345	COG1702	phosphate starvation-inducible protein PhoH
I4Q40_04355	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
I4Q40_04360	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
I4Q40_04365	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
I4Q40_04370	COG1381	Involved in DNA repair and RecF pathway recombination
I4Q40_04375	COG0752	glycyl-tRNA synthetase alpha subunit
I4Q40_04380	COG0751	glycine-tRNA ligase activity
I4Q40_04390	COG1316	TRANSCRIPTIONal
I4Q40_04395	COG3944	biosynthesis protein
I4Q40_04400	COG0489	protein tyrosine kinase activity
I4Q40_04405	COG4464	protein tyrosine phosphatase activity
I4Q40_04420	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
I4Q40_04425	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
I4Q40_04430	COG1215	transferase activity, transferring glycosyl groups
I4Q40_04445	COG0438	transferase activity, transferring glycosyl groups
I4Q40_04455	COG0706	membrane insertase activity
I4Q40_04460	COG1254	Belongs to the acylphosphatase family
I4Q40_04465	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I4Q40_04480	COG0038	chloride channel
I4Q40_04490	COG1686	Belongs to the peptidase S11 family
I4Q40_04505	COG1278	Cold shock
I4Q40_04510	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I4Q40_04510	COG1199	ATP-dependent helicase activity
I4Q40_04520	COG0436	Aminotransferase
I4Q40_04525	COG0017	Asparaginyl-tRNA synthetase
I4Q40_04550	COG2217	Heavy metal translocating P-type atpase
I4Q40_04555	COG0531	amino acid
I4Q40_04565	COG3682	Transcriptional regulator
I4Q40_04570	COG2608	mercury ion transmembrane transporter activity
I4Q40_04575	COG2217	Heavy metal translocating P-type atpase
I4Q40_04580	COG2217	Heavy metal translocating P-type atpase
I4Q40_04600	COG0714	Associated with various cellular activities
I4Q40_04625	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
I4Q40_04630	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
I4Q40_04640	COG5002	protein histidine kinase activity
I4Q40_04645	COG0745	RESPONSE REGULATOR receiver
I4Q40_04655	COG2739	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein
I4Q40_04660	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
I4Q40_04665	COG0519	Catalyzes the synthesis of GMP from XMP
I4Q40_04675	COG0431	NADPH-dependent FMN reductase
I4Q40_04680	COG1476	TRANSCRIPTIONal
I4Q40_04690	COG1131	(ABC) transporter
I4Q40_04700	COG0228	four-way junction DNA binding
I4Q40_04705	COG1837	Belongs to the UPF0109 family
I4Q40_04715	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
I4Q40_04720	COG0336	Belongs to the RNA methyltransferase TrmD family
I4Q40_04725	COG0335	large ribosomal subunit rRNA binding
I4Q40_04735	COG0028	Belongs to the TPP enzyme family
I4Q40_04740	COG3527	Alpha-acetolactate decarboxylase
I4Q40_04745	COG1956	GAF domain-containing protein
I4Q40_04830	COG0745	RESPONSE REGULATOR receiver
I4Q40_04835	COG3850	Histidine kinase
I4Q40_04835	COG5002	protein histidine kinase activity
I4Q40_04850	COG1368	sulfuric ester hydrolase activity
I4Q40_04855	COG1092	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA
I4Q40_04860	COG0710	3-dehydroquinate dehydratase activity
I4Q40_04865	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
I4Q40_04870	COG2081	HI0933 family
I4Q40_04875	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I4Q40_04880	COG0166	Belongs to the GPI family
I4Q40_04885	COG4974	Belongs to the 'phage' integrase family
I4Q40_04900	COG3620	sequence-specific DNA binding
I4Q40_04945	COG3049	Linear amide C-N hydrolases, choloylglycine hydrolase family
I4Q40_04970	COG0584	glycerophosphoryl diester phosphodiesterase
I4Q40_05000	COG1309	transcriptional regulator
I4Q40_05010	COG0367	asparagine synthase
I4Q40_05015	COG4876	unkown
I4Q40_05020	COG0267	Belongs to the bacterial ribosomal protein bL33 family
I4Q40_05040	COG1120	ATPase activity
I4Q40_05045	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I4Q40_05050	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I4Q40_05055	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
I4Q40_05070	COG1940	carbohydrate kinase activity
I4Q40_05075	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I4Q40_05080	COG3189	MarR family transcriptional regulator
I4Q40_05095	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I4Q40_05100	COG4468	UDPglucose--hexose-1-phosphate uridylyltransferase
I4Q40_05105	COG1609	Transcriptional regulator
I4Q40_05110	COG1214	PFAM Peptidase M22, glycoprotease
I4Q40_05120	COG0456	acetyltransferase
I4Q40_05125	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
I4Q40_05130	COG0489	protein tyrosine kinase activity
I4Q40_05135	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I4Q40_05140	COG2235	arginine
I4Q40_05155	COG0018	arginyl-trna synthetase
I4Q40_05160	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I4Q40_05160	COG0075	2-aminoethylphosphonate-pyruvate transaminase activity
I4Q40_05170	COG1438	arginine binding
I4Q40_05175	COG0052	Belongs to the universal ribosomal protein uS2 family
I4Q40_05180	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
I4Q40_05185	COG0528	UMP kinase activity
I4Q40_05190	COG0233	cytoplasmic translational termination
I4Q40_05195	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
I4Q40_05200	COG4589	Belongs to the CDS family
I4Q40_05205	COG0750	zinc metalloprotease
I4Q40_05210	COG0442	prolyl-tRNA aminoacylation
I4Q40_05215	COG2176	DNA-directed DNA polymerase activity
I4Q40_05220	COG0779	Required for maturation of 30S ribosomal subunits
I4Q40_05225	COG0195	Participates in both transcription termination and antitermination
I4Q40_05230	COG2740	Nucleic-acid-binding protein implicated in transcription termination
I4Q40_05245	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
I4Q40_05250	COG3957	D-xylulose 5-phosphate D-fructose 6-phosphate phosphoketolase
I4Q40_05255	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
I4Q40_05260	COG0196	riboflavin kinase activity
I4Q40_05270	COG4975	Glucose uptake
I4Q40_05340	COG0433	COG0433 Predicted ATPase
I4Q40_05360	COG0582	viral genome integration into host DNA
I4Q40_05365	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I4Q40_05370	COG1420	regulation of RNA biosynthetic process
I4Q40_05375	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
I4Q40_05380	COG0443	Heat shock 70 kDa protein
I4Q40_05385	COG0484	heat shock protein binding
I4Q40_05405	COG1126	abc transporter atp-binding protein
I4Q40_05410	COG0765	amino acid transport
I4Q40_05415	COG0556	nucleotide-excision repair
I4Q40_05420	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
I4Q40_05430	COG1794	racemase activity, acting on amino acids and derivatives
I4Q40_05435	COG1660	Displays ATPase and GTPase activities
I4Q40_05440	COG0391	Required for morphogenesis under gluconeogenic growth conditions
I4Q40_05445	COG1481	regulation of sporulation
I4Q40_05450	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
I4Q40_05480	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I4Q40_05495	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
I4Q40_05510	COG1714	RDD family
I4Q40_05520	COG0544	peptidyl-prolyl cis-trans isomerase activity
I4Q40_05525	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
I4Q40_05530	COG0218	Necessary for normal cell division and for the maintenance of normal septation
I4Q40_05550	COG1349	DNA-binding transcription factor activity
I4Q40_05555	COG1105	Belongs to the carbohydrate kinase PfkB family
I4Q40_05560	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I4Q40_05560	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I4Q40_05560	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I4Q40_05570	COG0210	DNA helicase
I4Q40_05575	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
I4Q40_05580	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
I4Q40_05585	COG0154	amidase activity
I4Q40_05590	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
I4Q40_05595	COG1597	lipid kinase activity
I4Q40_05600	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
I4Q40_05610	COG1132	(ABC) transporter
I4Q40_05620	COG4978	Transcriptional regulator
I4Q40_05620	COG0789	Transcriptional regulator
I4Q40_05625	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
I4Q40_05630	COG0657	acetylesterase activity
I4Q40_05635	COG1609	Transcriptional regulator
I4Q40_05650	COG3250	beta-galactosidase activity
I4Q40_05655	COG2876	3-deoxy-7-phosphoheptulonate synthase activity
I4Q40_05665	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
I4Q40_05670	COG0287	Prephenate dehydrogenase
I4Q40_05675	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
I4Q40_05680	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
I4Q40_05685	COG0077	Prephenate dehydratase
I4Q40_05690	COG2972	Histidine kinase
I4Q40_05695	COG4753	response regulator
I4Q40_05695	COG2207	Transcriptional regulator
I4Q40_05740	COG0588	phosphoglycerate mutase activity
I4Q40_05765	COG1054	Belongs to the UPF0176 family
I4Q40_05775	COG2183	response to ionizing radiation
I4Q40_05780	COG3091	SprT-like family
I4Q40_05785	COG1434	Gram-negative-bacterium-type cell wall biogenesis
I4Q40_05790	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
I4Q40_05805	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I4Q40_05805	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I4Q40_05810	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
I4Q40_05815	COG0237	dephospho-CoA kinase activity
I4Q40_05825	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
I4Q40_05835	COG1484	DNA-dependent DNA replication
I4Q40_05845	COG2384	SAM-dependent methyltransferase
I4Q40_05850	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
I4Q40_05855	COG2195	Cleaves the N-terminal amino acid of tripeptides
I4Q40_05860	COG1597	lipid kinase activity
I4Q40_05875	COG0542	response to heat
I4Q40_05895	COG0481	GTPase activity
I4Q40_05900	COG4974	Belongs to the 'phage' integrase family
I4Q40_05915	COG1396	sequence-specific DNA binding
I4Q40_05955	COG5377	YqaJ viral recombinase family
I4Q40_05960	COG3723	Recombinational DNA repair protein, rece pathway
I4Q40_06195	COG1278	Cold shock
I4Q40_06250	COG1388	LysM domain
I4Q40_06250	COG3942	CHAP domain
I4Q40_06305	COG4990	cell redox homeostasis
I4Q40_06325	COG3104	oligopeptide transport
I4Q40_06330	COG3857	The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination
I4Q40_06335	COG1074	ATP-dependent DNA helicase activity
I4Q40_06340	COG1733	regulation of RNA biosynthetic process
I4Q40_06345	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
I4Q40_06350	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I4Q40_06350	COG0072	phenylalanine-tRNA ligase activity
I4Q40_06360	COG1126	abc transporter atp-binding protein
I4Q40_06365	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I4Q40_06370	COG0765	amino acid transport
I4Q40_06375	COG0765	amino acid transport
I4Q40_06380	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
I4Q40_06385	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
I4Q40_06395	COG0517	IMP dehydrogenase activity
I4Q40_06400	COG0668	transmembrane transport
I4Q40_06405	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I4Q40_06410	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
I4Q40_06415	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
I4Q40_06445	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
I4Q40_06455	COG1234	tRNA 3'-trailer cleavage
I4Q40_06460	COG0300	oxidoreductase activity
I4Q40_06465	COG5416	Lipopolysaccharide assembly protein A domain
I4Q40_06470	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
I4Q40_06470	COG4199	Single-strand DNA-specific exonuclease, C terminal domain
I4Q40_06475	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
I4Q40_06485	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
I4Q40_06500	COG1705	Flagellar rod assembly protein muramidase FlgJ
I4Q40_06500	COG1388	LysM domain
I4Q40_06505	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I4Q40_06510	COG0735	belongs to the Fur family
I4Q40_06515	COG0446	pyridine nucleotide-disulphide oxidoreductase
I4Q40_06525	COG1846	Transcriptional regulator
I4Q40_06535	COG3935	DnaD domain protein
I4Q40_06540	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
I4Q40_06545	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I4Q40_06550	COG3331	DNA recombination
I4Q40_06555	COG4474	Belongs to the UPF0398 family
I4Q40_06560	COG3599	regulation of cell shape
I4Q40_06570	COG0116	Belongs to the methyltransferase superfamily
I4Q40_06575	COG2317	Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues
I4Q40_06580	COG1418	mRNA catabolic process
I4Q40_06585	COG0156	8-amino-7-oxononanoate synthase activity
I4Q40_06590	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I4Q40_06595	COG0531	amino acid
I4Q40_06605	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
I4Q40_06620	COG0513	Belongs to the DEAD box helicase family
I4Q40_06625	COG2153	protein acetylation
I4Q40_06630	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
I4Q40_06635	COG4684	Psort location CytoplasmicMembrane, score
I4Q40_06645	COG0328	RNA-DNA hybrid ribonuclease activity
I4Q40_06655	COG1278	Cold shock
I4Q40_06660	COG2759	Belongs to the formate--tetrahydrofolate ligase family
I4Q40_06675	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
I4Q40_06680	COG0564	pseudouridine synthase activity
I4Q40_06690	COG2233	PERMEase
I4Q40_06695	COG0540	Belongs to the ATCase OTCase family
I4Q40_06700	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
I4Q40_06705	COG0505	Belongs to the CarA family
I4Q40_06710	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
I4Q40_06715	COG0543	2 iron, 2 sulfur cluster binding
I4Q40_06740	COG3715	PTS system
I4Q40_06745	COG3716	PTS system mannose fructose sorbose family IID component
I4Q40_06750	COG2222	sugar isomerase
I4Q40_06755	COG3933	PFAM sigma-54 factor interaction domain-containing protein
I4Q40_06755	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
I4Q40_06760	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I4Q40_06780	COG1293	RNA-binding protein homologous to eukaryotic snRNP
I4Q40_06795	COG4120	Belongs to the binding-protein-dependent transport system permease family
I4Q40_06800	COG3638	Part of the ABC transporter complex PhnCDE involved in phosphonates import. Responsible for energy coupling to the transport system
I4Q40_06805	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
I4Q40_06840	COG0039	L-malate dehydrogenase activity
I4Q40_06875	COG3037	sugar-specific permease SgaT UlaA
I4Q40_06885	COG3711	transcriptional antiterminator
I4Q40_06895	COG0673	inositol 2-dehydrogenase activity
I4Q40_06945	COG0745	RESPONSE REGULATOR receiver
I4Q40_06950	COG5002	protein histidine kinase activity
I4Q40_06955	COG3861	electron transporter, transferring electrons within the cyclic electron transport pathway of photosynthesis activity
I4Q40_06985	COG0351	phosphomethylpyrimidine kinase
I4Q40_06995	COG4475	Protein of unknown function (DUF436)
I4Q40_07000	COG0366	Alpha amylase catalytic
I4Q40_07015	COG1307	EDD domain protein, DegV family
I4Q40_07020	COG2244	polysaccharide biosynthetic process
I4Q40_07070	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I4Q40_07075	COG0194	GDP metabolic process
I4Q40_07095	COG0765	amino acid transport
I4Q40_07100	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I4Q40_07110	COG0167	dihydroorotate dehydrogenase activity
I4Q40_07120	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
I4Q40_07130	COG3833	ABC-type maltose transport systems, permease component
I4Q40_07135	COG1175	transmembrane transport
I4Q40_07140	COG2182	Extracellular solute-binding protein
I4Q40_07145	COG0366	Alpha amylase catalytic
I4Q40_07150	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I4Q40_07160	COG1764	response to oxidative stress
I4Q40_07165	COG1846	Transcriptional regulator
I4Q40_07170	COG0628	permease
I4Q40_07190	COG0246	Mannitol dehydrogenase
I4Q40_07200	COG0450	alkyl hydroperoxide reductase
I4Q40_07225	COG0768	penicillin binding
I4Q40_07245	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I4Q40_07260	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
I4Q40_07275	COG0531	amino acid
I4Q40_07280	COG0004	ammonium transporteR
I4Q40_07285	COG2261	transglycosylase associated protein
I4Q40_07335	COG3655	Transcriptional regulator
I4Q40_07355	COG2261	transglycosylase associated protein
I4Q40_07375	COG1028	Short-chain dehydrogenase reductase Sdr
I4Q40_07390	COG1442	glycosyl transferase family 8
I4Q40_07395	COG1442	glycosyl transferase family 8
I4Q40_07400	COG0561	phosphatase activity
I4Q40_07425	COG1476	TRANSCRIPTIONal
I4Q40_07440	COG1278	Cold shock
I4Q40_07445	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
I4Q40_07460	COG2272	Belongs to the type-B carboxylesterase lipase family
I4Q40_07465	COG1073	alpha beta
I4Q40_07490	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I4Q40_07495	COG0584	glycerophosphoryl diester phosphodiesterase
I4Q40_07510	COG3732	PTS system glucitol sorbitol-specific
I4Q40_07515	COG3730	PTS system glucitol sorbitol-specific
I4Q40_07525	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I4Q40_07525	COG3711	transcriptional antiterminator
I4Q40_07590	COG4974	Belongs to the 'phage' integrase family
I4Q40_07595	COG2151	metal-sulfur cluster biosynthetic enzyme
I4Q40_07600	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I4Q40_07605	COG1666	GTP binding
I4Q40_07625	COG1968	undecaprenyl-diphosphatase activity
I4Q40_07630	COG2217	Heavy metal translocating P-type atpase
I4Q40_07635	COG2707	UPF0756 membrane protein
I4Q40_07645	COG0268	Binds directly to 16S ribosomal RNA
I4Q40_07650	COG1466	dna polymerase III delta subunit
I4Q40_07655	COG0658	competence protein
I4Q40_07655	COG2333	competence protein COMEC
I4Q40_07660	COG2131	deaminase
I4Q40_07665	COG1596	polysaccharide export
I4Q40_07665	COG1555	photosystem II stabilization
I4Q40_07670	COG3480	Lon protease (S16) C-terminal proteolytic domain
I4Q40_07675	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
I4Q40_07680	COG0742	ribosomal rna small subunit methyltransferase
I4Q40_07685	COG4471	UPF0298 protein
I4Q40_07700	COG1038	Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second
I4Q40_07705	COG0772	Belongs to the SEDS family
I4Q40_07710	COG4838	Belongs to the UPF0358 family
I4Q40_07715	COG0514	ATP-dependent DNA helicase (RecQ)
I4Q40_07720	COG1217	gtp-binding protein TYPA
I4Q40_07725	COG0483	inositol monophosphate 1-phosphatase activity
I4Q40_07730	COG4476	Belongs to the UPF0223 family
I4Q40_07745	COG0022	dehydrogenase e1 component
I4Q40_07755	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I4Q40_07760	COG0516	GMP reductase activity
I4Q40_07765	COG4214	carbohydrate transport
I4Q40_07775	COG4213	ABC transporter substrate-binding protein
I4Q40_07785	COG2972	Histidine kinase
I4Q40_07800	COG4989	oxidoreductase activity
I4Q40_07805	COG0151	Belongs to the GarS family
I4Q40_07810	COG0138	bifunctional purine biosynthesis protein purh
I4Q40_07815	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
I4Q40_07820	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
I4Q40_07830	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
I4Q40_07835	COG0047	phosphoribosylformylglycinamidine synthase activity
I4Q40_07840	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
I4Q40_07855	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
I4Q40_07860	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
I4Q40_07865	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
I4Q40_07870	COG2233	PERMEase
I4Q40_07875	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
I4Q40_07885	COG0673	inositol 2-dehydrogenase activity
I4Q40_07895	COG0395	ABC-type sugar transport system, permease component
I4Q40_07900	COG1175	transmembrane transport
I4Q40_07905	COG1653	transport
I4Q40_07920	COG1876	peptidase activity
I4Q40_07930	COG0673	inositol 2-dehydrogenase activity
I4Q40_07945	COG2268	Band 7 protein
I4Q40_07955	COG3290	protein histidine kinase activity
I4Q40_07960	COG4565	transcriptional regulatory protein
I4Q40_07965	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I4Q40_07985	COG0436	Aminotransferase
I4Q40_08010	COG3942	CHAP domain
I4Q40_08010	COG1388	LysM domain
I4Q40_08015	COG0084	hydrolase, TatD family'
I4Q40_08020	COG1116	anion transmembrane transporter activity
I4Q40_08030	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I4Q40_08045	COG1732	Glycine betaine
I4Q40_08055	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I4Q40_08065	COG1609	Transcriptional regulator
I4Q40_08070	COG1073	alpha beta
I4Q40_08080	COG4843	Uncharacterized protein conserved in bacteria (DUF2179)
I4Q40_08095	COG1227	inorganic diphosphatase activity
I4Q40_08100	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
I4Q40_08105	COG1882	Formate acetyltransferase
I4Q40_08115	COG0187	DNA topoisomerase II activity
I4Q40_08120	COG1832	CoA-binding protein
I4Q40_08125	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
I4Q40_08135	COG4465	DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor
I4Q40_08140	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
I4Q40_08145	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
I4Q40_08150	COG4974	Belongs to the 'phage' integrase family
I4Q40_08155	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
I4Q40_08160	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I4Q40_08165	COG0758	DNA mediated transformation
I4Q40_08170	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
I4Q40_08175	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
I4Q40_08190	COG0681	Belongs to the peptidase S26 family
I4Q40_08195	COG4479	Belongs to the UPF0346 family
I4Q40_08210	COG2755	lipolytic protein G-D-S-L family
I4Q40_08215	COG1307	EDD domain protein, DegV family
I4Q40_08220	COG1272	protein, Hemolysin III
I4Q40_08230	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
I4Q40_08235	COG0488	(ABC) transporter
I4Q40_08240	COG0025	NhaP-type Na H and K H
I4Q40_08255	COG0617	tRNA 3'-terminal CCA addition
I4Q40_08260	COG1694	Mazg nucleotide pyrophosphohydrolase
I4Q40_08265	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I4Q40_08270	COG5582	Belongs to the UPF0302 family
I4Q40_08275	COG0457	Tetratricopeptide repeat
I4Q40_08285	COG0776	regulation of translation
I4Q40_08290	COG1160	GTP binding
I4Q40_08295	COG0539	negative regulation of cytoplasmic translation
I4Q40_08300	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
I4Q40_08310	COG0514	ATP-dependent DNA helicase (RecQ)
I4Q40_08330	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I4Q40_08335	COG1288	antiporter activity
I4Q40_08340	COG3601	Mediates riboflavin uptake, may also transport FMN and roseoflavin. Probably a riboflavin-binding protein that interacts with the energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. The substrates themselves are bound by transmembrane, not extracytoplasmic soluble proteins
I4Q40_08345	COG1187	pseudouridine synthase activity
I4Q40_08350	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
I4Q40_08355	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
I4Q40_08365	COG4974	Belongs to the 'phage' integrase family
I4Q40_08370	COG0735	belongs to the Fur family
I4Q40_08375	COG2996	Protein conserved in bacteria
I4Q40_08385	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I4Q40_08390	COG0358	DNA primase activity
I4Q40_08395	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
I4Q40_08405	COG0741	lytic transglycosylase activity
I4Q40_08410	COG0596	Alpha beta hydrolase
I4Q40_08415	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
I4Q40_08415	COG0392	lysyltransferase activity
I4Q40_08435	COG0656	L-ascorbic acid biosynthetic process
I4Q40_08455	COG0183	Belongs to the thiolase family
I4Q40_08460	COG3425	synthase
I4Q40_08470	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
I4Q40_08475	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I4Q40_08480	COG0351	phosphomethylpyrimidine kinase
I4Q40_08490	COG1393	Belongs to the ArsC family
I4Q40_08505	COG0589	response to stress
I4Q40_08510	COG2723	6-phospho-beta-galactosidase activity
I4Q40_08515	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I4Q40_08520	COG2188	Transcriptional regulator
I4Q40_08525	COG0346	lactoylglutathione lyase activity
I4Q40_08530	COG0400	carboxylic ester hydrolase activity
I4Q40_08545	COG3775	system Galactitol-specific IIC component
I4Q40_08555	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I4Q40_08560	COG1349	DNA-binding transcription factor activity
I4Q40_08565	COG1105	Belongs to the carbohydrate kinase PfkB family
I4Q40_08575	COG0789	Transcriptional regulator
I4Q40_08580	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I4Q40_08585	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I4Q40_08590	COG4720	Psort location CytoplasmicMembrane, score
I4Q40_08595	COG1122	ATPase activity
I4Q40_08600	COG0619	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates
I4Q40_08625	COG3623	hexulose-6-phosphate isomerase
I4Q40_08630	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
I4Q40_08655	COG1349	DNA-binding transcription factor activity
I4Q40_08660	COG2723	6-phospho-beta-galactosidase activity
I4Q40_08665	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I4Q40_08680	COG1737	Transcriptional regulator
I4Q40_08685	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I4Q40_08685	COG1263	PTS System
I4Q40_08690	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
I4Q40_08715	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I4Q40_08815	COG5002	protein histidine kinase activity
I4Q40_08820	COG0745	RESPONSE REGULATOR receiver
I4Q40_08825	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
I4Q40_08830	COG0333	Belongs to the bacterial ribosomal protein bL32 family
I4Q40_08840	COG0583	DNA-binding transcription factor activity
I4Q40_08850	COG0205	6-phosphofructokinase activity
I4Q40_08855	COG0587	DNA-directed DNA polymerase activity
I4Q40_08865	COG2814	Major facilitator Superfamily
I4Q40_08870	COG2252	PERMEase
I4Q40_08875	COG0561	phosphatase activity
I4Q40_08880	COG0768	penicillin binding
I4Q40_08885	COG1737	Transcriptional regulator
I4Q40_08890	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
I4Q40_08895	COG1942	4-Oxalocrotonate Tautomerase
I4Q40_08905	COG3973	AAA domain
I4Q40_08915	COG0217	transcriptional regulatory protein
I4Q40_08920	COG1323	Belongs to the UPF0348 family
I4Q40_08925	COG2226	methyltransferase
I4Q40_08930	COG0799	negative regulation of ribosome biogenesis
I4Q40_08935	COG1713	HD superfamily hydrolase involved in NAD metabolism
I4Q40_08940	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
I4Q40_08945	COG1534	Rna-binding protein
I4Q40_08950	COG1161	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity
I4Q40_08955	COG2179	HAD superfamily (subfamily IIIA) phosphatase, TIGR01668
I4Q40_08960	COG0825	malonyl-CoA metabolic process
I4Q40_08965	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
I4Q40_08970	COG0439	Biotin carboxylase
I4Q40_08975	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
I4Q40_08985	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I4Q40_08995	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
I4Q40_09005	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
I4Q40_09010	COG1846	Transcriptional regulator
I4Q40_09015	COG0322	excinuclease ABC activity
I4Q40_09020	COG4703	Protein of unknown function (DUF1797)
I4Q40_09025	COG2084	Dehydrogenase
I4Q40_09030	COG0438	transferase activity, transferring glycosyl groups
I4Q40_09040	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I4Q40_09045	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I4Q40_09050	COG0542	response to heat
I4Q40_09065	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
I4Q40_09070	COG1253	flavin adenine dinucleotide binding
I4Q40_09075	COG0628	permease
I4Q40_09090	COG3557	Belongs to the UPF0374 family
I4Q40_09095	COG1194	a g-specific adenine glycosylase
I4Q40_09100	COG2137	regulation of response to DNA damage stimulus
I4Q40_09105	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
I4Q40_09110	COG3397	chitin binding
I4Q40_09120	COG3476	COG3476 Tryptophan-rich sensory protein (mitochondrial benzodiazepine receptor homolog)
I4Q40_09125	COG1316	TRANSCRIPTIONal
I4Q40_09130	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
I4Q40_09165	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
I4Q40_09170	COG2246	polysaccharide biosynthetic process
I4Q40_09195	COG0569	domain protein
I4Q40_09200	COG5492	domain, Protein
I4Q40_09210	COG4585	Histidine kinase
I4Q40_09220	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I4Q40_09225	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
I4Q40_09245	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
I4Q40_09260	COG0463	Glycosyl transferase, family 2
I4Q40_09260	COG1887	Glycosyl glycerophosphate transferases involved in teichoic acid biosynthesis TagF TagB EpsJ RodC
I4Q40_09265	COG1216	Glycosyl transferase, family 2
I4Q40_09265	COG1442	glycosyl transferase family 8
I4Q40_09270	COG1215	transferase activity, transferring glycosyl groups
I4Q40_09275	COG1216	Glycosyl transferase, family 2
I4Q40_09280	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
I4Q40_09285	COG0438	transferase activity, transferring glycosyl groups
I4Q40_09285	COG1216	Glycosyl transferase, family 2
I4Q40_09290	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
I4Q40_09300	COG1682	transport, permease protein
I4Q40_09315	COG1091	dTDP-4-dehydrorhamnose reductase activity
I4Q40_09320	COG1088	dTDP-glucose 4,6-dehydratase activity
I4Q40_09325	COG1898	dTDP-4-dehydrorhamnose 3,5-epimerase activity
I4Q40_09330	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
I4Q40_09335	COG1215	transferase activity, transferring glycosyl groups
I4Q40_09350	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I4Q40_09355	COG1295	ribonuclease BN
I4Q40_09360	COG0024	Methionine aminopeptidase
I4Q40_09365	COG0716	FMN binding
I4Q40_09375	COG2309	aminopeptidase activity
I4Q40_09490	COG0740	serine-type endopeptidase activity
I4Q40_09655	COG1396	sequence-specific DNA binding
I4Q40_09715	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I4Q40_09720	COG1447	Phosphotransferase system cellobiose-specific component IIA
I4Q40_09725	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I4Q40_09730	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
I4Q40_09730	COG3933	PFAM sigma-54 factor interaction domain-containing protein
I4Q40_09735	COG0513	Belongs to the DEAD box helicase family
I4Q40_09740	COG0673	inositol 2-dehydrogenase activity
I4Q40_09760	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
I4Q40_09765	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
I4Q40_09770	COG3599	regulation of cell shape
I4Q40_09775	COG2302	S4 RNA-binding domain
I4Q40_09785	COG1799	cell septum assembly
I4Q40_09790	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
I4Q40_09825	COG0768	penicillin binding
I4Q40_09860	COG0497	DNA recombination
I4Q40_09865	COG1438	arginine binding
I4Q40_09870	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
I4Q40_09880	COG1722	exodeoxyribonuclease VII activity
I4Q40_09885	COG1570	exodeoxyribonuclease VII activity
I4Q40_09890	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
I4Q40_09895	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
I4Q40_09900	COG1302	Protein conserved in bacteria
I4Q40_09905	COG0006	proline dipeptidase activity
I4Q40_09910	COG2261	transglycosylase associated protein
I4Q40_09920	COG3716	PTS system mannose fructose sorbose family IID component
I4Q40_09925	COG3715	PTS system
I4Q40_09935	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I4Q40_09935	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
I4Q40_09940	COG3933	PFAM sigma-54 factor interaction domain-containing protein
I4Q40_09940	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
I4Q40_09945	COG0211	Belongs to the bacterial ribosomal protein bL27 family
I4Q40_09955	COG0261	This protein binds to 23S rRNA in the presence of protein L20
I4Q40_09965	COG0659	secondary active sulfate transmembrane transporter activity
I4Q40_09970	COG3759	membrane
I4Q40_09995	COG0095	Lipoate-protein ligase
I4Q40_10000	COG1234	tRNA 3'-trailer cleavage
I4Q40_10010	COG1363	Peptidase, m42
I4Q40_10015	COG3966	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein)
I4Q40_10020	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I4Q40_10025	COG1696	Membrane protein involved in D-alanine export
I4Q40_10030	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I4Q40_10050	COG1136	(ABC) transporter
I4Q40_10055	COG1328	CTP reductase activity
I4Q40_10060	COG0602	queuosine metabolic process
I4Q40_10075	COG4467	Involved in initiation control of chromosome replication
I4Q40_10080	COG1774	PSP1 C-terminal conserved region
I4Q40_10085	COG0470	DNA polymerase III
I4Q40_10090	COG3870	Protein conserved in bacteria
I4Q40_10095	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
I4Q40_10100	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
I4Q40_10105	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
I4Q40_10110	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
I4Q40_10130	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I4Q40_10140	COG2814	Major facilitator Superfamily
I4Q40_10195	COG0254	rRNA binding
I4Q40_10200	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
I4Q40_10205	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
I4Q40_10215	COG0504	CTP synthase activity
I4Q40_10225	COG0789	Transcriptional regulator
I4Q40_10230	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
I4Q40_10235	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
I4Q40_10240	COG0584	glycerophosphoryl diester phosphodiesterase
I4Q40_10250	COG0740	serine-type endopeptidase activity
I4Q40_10255	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
I4Q40_10265	COG1132	(ABC) transporter
I4Q40_10275	COG5503	Protein of unknown function (DUF1447)
I4Q40_10285	COG1278	Cold shock
I4Q40_10290	COG2003	Belongs to the UPF0758 family
I4Q40_10295	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I4Q40_10300	COG0285	dihydrofolate synthase activity
I4Q40_10305	COG0525	valine-tRNA ligase activity
I4Q40_10310	COG2344	Modulates transcription in response to changes in cellular NADH NAD( ) redox state
I4Q40_10315	COG0301	tRNA thio-modification
I4Q40_10320	COG1104	cysteine desulfurase activity
I4Q40_10325	COG4477	modulates the frequency and position of FtsZ ring formation. Inhibits FtsZ ring formation at polar sites. Interacts either with FtsZ or with one of its binding partners to promote depolymerization
I4Q40_10335	COG0561	phosphatase activity
I4Q40_10340	COG1801	Protein of unknown function DUF72
I4Q40_10360	COG3579	cysteine-type endopeptidase activity
I4Q40_10390	COG2723	6-phospho-beta-galactosidase activity
I4Q40_10395	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I4Q40_10395	COG2190	(PTS) system
I4Q40_10395	COG1263	PTS System
I4Q40_10400	COG3711	transcriptional antiterminator
I4Q40_10415	COG0549	Belongs to the carbamate kinase family
I4Q40_10420	COG2957	Belongs to the agmatine deiminase family
I4Q40_10465	COG1098	S1 RNA binding domain
I4Q40_10470	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
I4Q40_10480	COG0492	ferredoxin-NADP+ reductase activity
I4Q40_10485	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
I4Q40_10500	COG4470	Protein conserved in bacteria
I4Q40_10505	COG0737	Belongs to the 5'-nucleotidase family
I4Q40_10515	COG0590	tRNA wobble adenosine to inosine editing
I4Q40_10520	COG2508	Transcriptional regulator
I4Q40_10530	COG3270	Specifically methylates the cytosine at position 1407 (m5C1407) of 16S rRNA
I4Q40_10530	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
I4Q40_10545	COG2738	Putative neutral zinc metallopeptidase
I4Q40_10550	COG2824	Alkylphosphonate utilization operon protein PhnA
I4Q40_10555	COG0618	3'(2'),5'-bisphosphate nucleotidase activity
I4Q40_10560	COG4109	DRTGG domain
I4Q40_10565	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
I4Q40_10580	COG0577	efflux transmembrane transporter activity
I4Q40_10585	COG1136	(ABC) transporter
I4Q40_10595	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
I4Q40_10600	COG1288	antiporter activity
I4Q40_10605	COG4821	SIS domain
I4Q40_10620	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
I4Q40_10625	COG3469	chitinase activity
I4Q40_10635	COG3397	chitin binding
I4Q40_10645	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
I4Q40_10650	COG3716	PTS system mannose fructose sorbose family IID component
I4Q40_10655	COG3715	PTS system
I4Q40_10670	COG3933	PFAM sigma-54 factor interaction domain-containing protein
I4Q40_10670	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
I4Q40_10685	COG1132	(ABC) transporter
I4Q40_10690	COG1132	(ABC) transporter
I4Q40_10700	COG1803	Methylglyoxal synthase
I4Q40_10705	COG3842	ATPase activity
I4Q40_10715	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
I4Q40_10720	COG1658	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step
I4Q40_10725	COG0084	hydrolase, TatD family'
I4Q40_10735	COG0531	amino acid
I4Q40_10750	COG0143	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I4Q40_10750	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I4Q40_10765	COG0675	Transposase, IS605 OrfB family
I4Q40_10770	COG4608	Belongs to the ABC transporter superfamily
I4Q40_10775	COG0444	Belongs to the ABC transporter superfamily
I4Q40_10780	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I4Q40_10785	COG0601	transmembrane transport
I4Q40_10795	COG4166	transmembrane transport
I4Q40_10810	COG0820	rRNA (adenine-C2-)-methyltransferase activity
I4Q40_10815	COG1674	ftsk spoiiie
I4Q40_10815	COG1280	lysine exporter protein (LysE YggA)
I4Q40_10820	COG2723	6-phospho-beta-galactosidase activity
I4Q40_10825	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I4Q40_10830	COG1126	abc transporter atp-binding protein
I4Q40_10835	COG0765	amino acid transport
I4Q40_10865	COG0035	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate
I4Q40_10875	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
I4Q40_10880	COG0009	L-threonylcarbamoyladenylate synthase
I4Q40_10885	COG2890	protein-(glutamine-N5) methyltransferase activity
I4Q40_10890	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
I4Q40_10895	COG1435	thymidine kinase activity
I4Q40_10900	COG2226	methyltransferase
I4Q40_10905	COG0681	Belongs to the peptidase S26 family
I4Q40_10925	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
I4Q40_10930	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
I4Q40_10935	COG3442	glutamine amidotransferase
I4Q40_10940	COG0246	Mannitol dehydrogenase
I4Q40_10945	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
I4Q40_10950	COG2213	PTS system mannitol-specific
I4Q40_10955	COG1137	ATPase activity
I4Q40_10965	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
I4Q40_10970	COG3711	transcriptional antiterminator
I4Q40_10975	COG2213	PTS system mannitol-specific
I4Q40_10980	COG1482	cell wall glycoprotein biosynthetic process
I4Q40_10995	COG1132	(ABC) transporter
I4Q40_11015	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
I4Q40_11020	COG0628	permease
I4Q40_11030	COG2706	6-phosphogluconolactonase activity
I4Q40_11045	COG1368	sulfuric ester hydrolase activity
I4Q40_11050	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I4Q40_11055	COG2160	L-arabinose isomerase activity
I4Q40_11060	COG0235	Class ii aldolase
I4Q40_11080	COG3940	Belongs to the glycosyl hydrolase 43 family
I4Q40_11085	COG3534	alpha-L-arabinofuranosidase
I4Q40_11095	COG0395	ABC-type sugar transport system, permease component
I4Q40_11100	COG1175	transmembrane transport
I4Q40_11120	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
I4Q40_11125	COG1488	Catalyzes the synthesis of beta-nicotinate D- ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP
I4Q40_11165	COG0789	Transcriptional regulator
I4Q40_11170	COG1609	Transcriptional regulator
I4Q40_11180	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I4Q40_11185	COG0459	protein refolding
I4Q40_11190	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
I4Q40_11200	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I4Q40_11205	COG2910	NAD(P)H-binding
I4Q40_11210	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
I4Q40_11225	COG5002	protein histidine kinase activity
I4Q40_11230	COG0745	RESPONSE REGULATOR receiver
I4Q40_11235	COG1307	EDD domain protein, DegV family
I4Q40_11255	COG4175	Glycine betaine
I4Q40_11255	COG3448	diguanylate cyclase activity
I4Q40_11280	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
I4Q40_11285	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I4Q40_11310	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I4Q40_11310	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
I4Q40_11315	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
I4Q40_11325	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I4Q40_11330	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I4Q40_11330	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I4Q40_11330	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I4Q40_11335	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I4Q40_11350	COG2188	Transcriptional regulator
I4Q40_11355	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
I4Q40_11380	COG0628	permease
I4Q40_11385	COG1285	pathogenesis
I4Q40_11390	COG0363	glucosamine-6-phosphate deaminase activity
I4Q40_11395	COG0488	(ABC) transporter
I4Q40_11400	COG2814	Major facilitator Superfamily
I4Q40_11410	COG0222	ribosome binding
I4Q40_11415	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
I4Q40_11420	COG0081	regulation of translation
I4Q40_11425	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
I4Q40_11430	COG1760	l-serine dehydratase
I4Q40_11435	COG1760	l-serine dehydratase
I4Q40_11440	COG1304	FMN binding
I4Q40_11450	COG0250	Participates in transcription elongation, termination and antitermination
I4Q40_11460	COG0267	Belongs to the bacterial ribosomal protein bL33 family
I4Q40_11475	COG1597	lipid kinase activity
I4Q40_11480	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I4Q40_11490	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
I4Q40_11500	COG3142	Participates in the control of copper homeostasis
I4Q40_11505	COG2239	Acts as a magnesium transporter
I4Q40_11510	COG0564	pseudouridine synthase activity
I4Q40_11515	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
I4Q40_11520	COG2357	RelA SpoT domain protein
I4Q40_11525	COG4116	CYTH
I4Q40_11545	COG4862	establishment of competence for transformation
I4Q40_11550	COG1393	Belongs to the ArsC family
I4Q40_11565	COG0419	ATPase involved in DNA repair
I4Q40_11570	COG0420	3'-5' exonuclease activity
I4Q40_11575	COG0204	Acyl-transferase
I4Q40_11580	COG4123	Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC)
I4Q40_11585	COG2827	Endonuclease containing a URI domain
I4Q40_11595	COG1284	Uncharacterised 5xTM membrane BCR, YitT family COG1284
I4Q40_11600	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
I4Q40_11605	COG0124	histidyl-tRNA synthetase
I4Q40_11610	COG0667	Aldo Keto reductase
I4Q40_11615	COG2124	cytochrome p450
I4Q40_11620	COG1490	D-aminoacyl-tRNA deacylase activity
I4Q40_11625	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I4Q40_11630	COG1385	rRNA (uridine-N3-)-methyltransferase activity
I4Q40_11635	COG2264	protein methyltransferase activity
I4Q40_11645	COG2094	Belongs to the DNA glycosylase MPG family
I4Q40_11650	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
I4Q40_11665	COG0589	response to stress
I4Q40_11670	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
I4Q40_11675	COG0827	DNA restriction-modification system
I4Q40_11700	COG4537	Required for transformation and DNA binding
I4Q40_11705	COG1459	type II secretion system
I4Q40_11710	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I4Q40_11720	COG0220	tRNA (guanine-N7-)-methyltransferase activity
I4Q40_11730	COG4473	ABC transporter
I4Q40_11735	COG1131	(ABC) transporter
I4Q40_11740	COG0537	adenosine 5'-monophosphoramidase activity
I4Q40_11750	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I4Q40_11755	COG3481	metal-dependent phosphohydrolase, HD sub domain
I4Q40_11760	COG4717	serine-type aminopeptidase activity
I4Q40_11765	COG0420	3'-5' exonuclease activity
I4Q40_11770	COG0561	phosphatase activity
I4Q40_11795	COG2211	Major facilitator Superfamily
I4Q40_11800	COG3507	Belongs to the glycosyl hydrolase 43 family
I4Q40_11815	COG1073	alpha beta
I4Q40_11825	COG4225	unsaturated rhamnogalacturonyl hydrolase activity
I4Q40_11840	COG4209	transmembrane transport
I4Q40_11845	COG0395	ABC-type sugar transport system, permease component
I4Q40_11850	COG2207	Transcriptional regulator
I4Q40_11855	COG1609	Transcriptional regulator
I4Q40_11860	COG0246	Mannitol dehydrogenase
I4Q40_11865	COG2721	sulfolactate sulfo-lyase activity
I4Q40_11870	COG1904	glucuronate isomerase
I4Q40_11875	COG2755	lipolytic protein G-D-S-L family
I4Q40_11885	COG1132	(ABC) transporter
I4Q40_11890	COG3679	Belongs to the UPF0342 family
I4Q40_11895	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I4Q40_11900	COG0564	pseudouridine synthase activity
I4Q40_11905	COG1940	carbohydrate kinase activity
I4Q40_11910	COG0383	alpha-mannosidase activity
I4Q40_11930	COG2207	Transcriptional regulator
I4Q40_11930	COG4753	response regulator
I4Q40_11935	COG2972	Histidine kinase
I4Q40_11945	COG1653	transport
I4Q40_11950	COG0395	ABC-type sugar transport system, permease component
I4Q40_11955	COG1175	transmembrane transport
I4Q40_11960	COG1187	pseudouridine synthase activity
I4Q40_11965	COG2244	polysaccharide biosynthetic process
I4Q40_11975	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
I4Q40_11985	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I4Q40_12000	COG3711	transcriptional antiterminator
I4Q40_12000	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I4Q40_12015	COG0495	leucyl-tRNA aminoacylation
I4Q40_12020	COG1388	LysM domain
I4Q40_12020	COG1705	Flagellar rod assembly protein muramidase FlgJ
I4Q40_12025	COG0671	phosphoesterase, PA-phosphatase related
I4Q40_12030	COG1242	4 iron, 4 sulfur cluster binding
I4Q40_12035	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
I4Q40_12040	COG1132	(ABC) transporter
I4Q40_12045	COG1132	(ABC) transporter
I4Q40_12060	COG0477	Major facilitator Superfamily
I4Q40_12065	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
I4Q40_12215	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
I4Q40_12220	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I4Q40_12225	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
I4Q40_12235	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
I4Q40_12240	COG0037	tRNA processing
I4Q40_12245	COG1098	S1 RNA binding domain
I4Q40_12255	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
I4Q40_12260	COG2244	polysaccharide biosynthetic process
I4Q40_12265	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
I4Q40_12270	COG0193	aminoacyl-tRNA hydrolase activity
I4Q40_12275	COG0039	L-malate dehydrogenase activity
I4Q40_12285	COG0217	transcriptional regulatory protein
I4Q40_12310	COG1792	Involved in formation and maintenance of cell shape
I4Q40_12320	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
I4Q40_12325	COG1162	GTPase activity
I4Q40_12330	COG0515	serine threonine protein kinase
I4Q40_12330	COG2815	serine threonine protein kinase
I4Q40_12335	COG0631	protein serine/threonine phosphatase activity
I4Q40_12340	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
I4Q40_12340	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
I4Q40_12345	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
I4Q40_12350	COG0242	peptide deformylase activity
I4Q40_12355	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
I4Q40_12360	COG1758	RNA polymerase activity
I4Q40_12365	COG0194	GDP metabolic process
I4Q40_12375	COG1561	YicC-like family, N-terminal region
I4Q40_12385	COG1752	Esterase of the alpha-beta hydrolase superfamily
I4Q40_12400	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
I4Q40_12405	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
I4Q40_12410	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
I4Q40_12415	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I4Q40_12420	COG1121	(ABC) transporter
I4Q40_12425	COG0803	Belongs to the bacterial solute-binding protein 9 family
I4Q40_12425	COG3443	Belongs to the bacterial solute-binding protein 9 family
I4Q40_12430	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
I4Q40_12435	COG0392	lysyltransferase activity
I4Q40_12435	COG2898	Catalyzes the transfer of a lysyl group from L-lysyl- tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), a major component of the bacterial membrane with a positive net charge. LPG synthesis contributes to bacterial virulence as it is involved in the resistance mechanism against cationic antimicrobial peptides (CAMP) produces by the host's immune system (defensins, cathelicidins) and by the competing microorganisms
I4Q40_12440	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
I4Q40_12445	COG1418	mRNA catabolic process
I4Q40_12450	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
I4Q40_12455	COG1546	Belongs to the CinA family
I4Q40_12455	COG1058	Belongs to the CinA family
I4Q40_12460	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
I4Q40_12465	COG1426	Protein conserved in bacteria
I4Q40_12470	COG0612	Peptidase, M16
I4Q40_12475	COG0612	Peptidase, M16
I4Q40_12480	COG1970	mechanosensitive ion channel activity
I4Q40_12485	COG2153	protein acetylation
I4Q40_12490	COG4466	Protein conserved in bacteria
I4Q40_12500	COG3688	RNA-binding protein containing a PIN domain
I4Q40_12505	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I4Q40_12510	COG1939	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
I4Q40_12515	COG0215	cysteine-tRNA ligase activity
I4Q40_12520	COG1045	serine acetyltransferase
I4Q40_12525	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I4Q40_12530	COG4956	integral membrane protein (PIN domain superfamily)
I4Q40_12540	COG0756	dUTP diphosphatase activity
I4Q40_12545	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
I4Q40_12550	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
I4Q40_12565	COG2814	Major facilitator Superfamily
I4Q40_12585	COG0778	Nitroreductase
I4Q40_12595	COG1705	Flagellar rod assembly protein muramidase FlgJ
I4Q40_12595	COG1388	LysM domain
I4Q40_12600	COG1388	LysM domain
I4Q40_12600	COG1705	Flagellar rod assembly protein muramidase FlgJ
I4Q40_12605	COG3711	transcriptional antiterminator
I4Q40_12610	COG2190	(PTS) system
I4Q40_12610	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I4Q40_12610	COG1263	PTS System
I4Q40_12615	COG0702	epimerase
I4Q40_12620	COG1959	2 iron, 2 sulfur cluster binding
I4Q40_12630	COG3708	Transcriptional regulator
I4Q40_12630	COG2207	Transcriptional regulator
I4Q40_12640	COG1070	Carbohydrate kinase
I4Q40_12645	COG0395	ABC-type sugar transport system, permease component
I4Q40_12660	COG3507	Belongs to the glycosyl hydrolase 43 family
I4Q40_12670	COG4499	WXG100 protein secretion system (Wss), protein YukC
I4Q40_12690	COG4842	Belongs to the WXG100 family
I4Q40_12700	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
I4Q40_12710	COG0604	alcohol dehydrogenase
I4Q40_12715	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I4Q40_12720	COG0842	Transport permease protein
I4Q40_12725	COG1131	(ABC) transporter
I4Q40_12730	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
I4Q40_12735	COG0383	alpha-mannosidase activity
I4Q40_12740	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I4Q40_12745	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I4Q40_12750	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I4Q40_12750	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I4Q40_12750	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I4Q40_12755	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I4Q40_12755	COG3711	transcriptional antiterminator
I4Q40_12760	COG2205	protein histidine kinase activity
I4Q40_12765	COG0745	RESPONSE REGULATOR receiver
I4Q40_12805	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
I4Q40_12810	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
I4Q40_12815	COG0783	Belongs to the Dps family
I4Q40_12820	COG1070	Carbohydrate kinase
I4Q40_12825	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
I4Q40_12830	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
I4Q40_12840	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
I4Q40_12845	COG0085	RNA polymerase activity
I4Q40_12855	COG4120	Belongs to the binding-protein-dependent transport system permease family
I4Q40_12865	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
I4Q40_12865	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
I4Q40_12920	COG0142	geranyltranstransferase activity
I4Q40_12940	COG4939	FMN-binding domain protein
I4Q40_12980	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I4Q40_12985	COG0826	peptidase U32
I4Q40_12990	COG0826	peptidase U32
I4Q40_12995	COG0542	response to heat
I4Q40_13000	COG4463	regulation of RNA biosynthetic process
I4Q40_13075	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
I4Q40_13080	COG0517	IMP dehydrogenase activity
I4Q40_13080	COG0516	GMP reductase activity
I4Q40_13090	COG0012	GTP binding
I4Q40_13095	COG4481	Protein conserved in bacteria
I4Q40_13100	COG1475	DNA binding
I4Q40_13105	COG1192	Involved in chromosome partitioning
I4Q40_13110	COG0357	Ribosomal RNA small subunit methyltransferase G
I4Q40_13115	COG0445	tRNA wobble uridine modification
I4Q40_13120	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
I4Q40_13130	COG1847	R3H domain protein
I4Q40_13135	COG0706	membrane insertase activity
I4Q40_13140	COG0594	ribonuclease P activity
I4Q40_13145	COG0230	Belongs to the bacterial ribosomal protein bL34 family