locus-tag	class	description
HQR01_00030	COG2119	membrane
HQR01_00065	COG0789	Transcriptional regulator
HQR01_00070	COG1199	ATP-dependent helicase activity
HQR01_00070	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HQR01_00080	COG4206	TonB-dependent receptor
HQR01_00100	COG0789	Transcriptional regulator
HQR01_00110	COG1228	amidohydrolase
HQR01_00115	COG0640	Transcriptional regulator
HQR01_00125	COG0382	Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3- octaprenyl-4-hydroxybenzoate
HQR01_00130	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HQR01_00165	COG2945	thiolester hydrolase activity
HQR01_00165	COG0596	Alpha beta hydrolase
HQR01_00170	COG0397	Uncharacterized ACR, YdiU/UPF0061 family
HQR01_00175	COG1012	belongs to the aldehyde dehydrogenase family
HQR01_00195	COG0418	dihydroorotase activity
HQR01_00200	COG0354	folic acid binding
HQR01_00220	COG0211	Belongs to the bacterial ribosomal protein bL27 family
HQR01_00225	COG0261	This protein binds to 23S rRNA in the presence of protein L20
HQR01_00240	COG0314	molybdopterin synthase activity
HQR01_00285	COG3175	Exerts its effect at some terminal stage of cytochrome c oxidase synthesis, probably by being involved in the insertion of the copper B into subunit I
HQR01_00290	COG0109	protoheme IX farnesyltransferase activity
HQR01_00295	COG0596	Alpha beta hydrolase
HQR01_00300	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HQR01_00305	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HQR01_00310	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
HQR01_00315	COG0736	holo-[acyl-carrier-protein] synthase activity
HQR01_00320	COG0681	Belongs to the peptidase S26 family
HQR01_00335	COG0816	Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA
HQR01_00350	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
HQR01_00380	COG1309	transcriptional regulator
HQR01_00390	COG5507	3-demethylubiquinone-9 3-methyltransferase
HQR01_00415	COG1741	Belongs to the pirin family
HQR01_00420	COG0300	oxidoreductase activity
HQR01_00425	COG0596	Alpha beta hydrolase
HQR01_00435	COG0040	Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of hisG enzymatic activity
HQR01_00440	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HQR01_00445	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HQR01_00450	COG2819	hydrolase of the alpha beta superfamily
HQR01_00455	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
HQR01_00460	COG3808	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
HQR01_00490	COG0556	nucleotide-excision repair
HQR01_00495	COG0513	Belongs to the DEAD box helicase family
HQR01_00510	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HQR01_00520	COG0235	Class ii aldolase
HQR01_00545	COG2818	Glycosylase
HQR01_00555	COG1309	transcriptional regulator
HQR01_00560	COG0640	Transcriptional regulator
HQR01_00575	COG0322	excinuclease ABC activity
HQR01_00580	COG0531	amino acid
HQR01_00585	COG2081	HI0933 family
HQR01_00605	COG0361	One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre- initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initation complex
HQR01_00610	COG0424	maF-like protein
HQR01_00620	COG3024	Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase
HQR01_00645	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HQR01_00650	COG0156	8-amino-7-oxononanoate synthase activity
HQR01_00655	COG0152	phosphoribosylaminoimidazolesuccinocarboxamide synthase activity
HQR01_00665	COG0612	Peptidase, M16
HQR01_00670	COG4771	TonB-dependent receptor
HQR01_00675	COG1828	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HQR01_00680	COG0047	phosphoribosylformylglycinamidine synthase activity
HQR01_00690	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HQR01_00730	COG0318	PFAM AMP-dependent synthetase and ligase
HQR01_00750	COG0232	Belongs to the dGTPase family. Type 2 subfamily
HQR01_00755	COG1404	Belongs to the peptidase S8 family
HQR01_00815	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HQR01_00820	COG4232	protein-disulfide reductase activity
HQR01_00840	COG2189	Belongs to the N(4) N(6)-methyltransferase family
HQR01_00850	COG1278	Cold shock
HQR01_00860	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HQR01_00865	COG2133	pyrroloquinoline quinone binding
HQR01_00885	COG0617	tRNA 3'-terminal CCA addition
HQR01_00895	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HQR01_00905	COG1335	isochorismatase
HQR01_00925	COG0633	Ferredoxin
HQR01_00930	COG1104	cysteine desulfurase activity
HQR01_00935	COG1104	cysteine desulfurase activity
HQR01_00940	COG2945	thiolester hydrolase activity
HQR01_00970	COG1866	Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA
HQR01_00975	COG0745	RESPONSE REGULATOR receiver
HQR01_00980	COG2205	protein histidine kinase activity
HQR01_00990	COG1660	Displays ATPase and GTPase activities
HQR01_00995	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HQR01_00995	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HQR01_01005	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HQR01_01050	COG1322	Protein conserved in bacteria
HQR01_01055	COG0242	peptide deformylase activity
HQR01_01060	COG0353	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO
HQR01_01065	COG0223	Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus
HQR01_01070	COG0101	tRNA pseudouridine synthase activity
HQR01_01080	COG0252	asparaginase activity
HQR01_01090	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HQR01_01095	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HQR01_01100	COG0165	Argininosuccinate lyase
HQR01_01110	COG0019	diaminopimelate decarboxylase activity
HQR01_01115	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HQR01_01115	COG1648	precorrin-2 dehydrogenase activity
HQR01_01135	COG1595	DNA-templated transcription, initiation
HQR01_01150	COG0104	Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP
HQR01_01165	COG1959	2 iron, 2 sulfur cluster binding
HQR01_01175	COG0306	phosphate transporter
HQR01_01185	COG3705	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine
HQR01_01190	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HQR01_01195	COG1932	Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine
HQR01_01205	COG0297	glycogen (starch) synthase activity
HQR01_01215	COG1695	Transcriptional regulator
HQR01_01220	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HQR01_01270	COG0536	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
HQR01_01275	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HQR01_01290	COG0175	sulfate reduction
HQR01_01300	COG0155	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HQR01_01310	COG1648	precorrin-2 dehydrogenase activity
HQR01_01310	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HQR01_01320	COG0626	cystathionine gamma-synthase activity
HQR01_01325	COG2897	thiosulfate sulfurtransferase activity
HQR01_01335	COG0780	Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1)
HQR01_01360	COG0670	Belongs to the BI1 family
HQR01_01375	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HQR01_01380	COG0849	cell division
HQR01_01385	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
HQR01_01390	COG1181	Belongs to the D-alanine--D-alanine ligase family
HQR01_01395	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HQR01_01400	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HQR01_01405	COG0707	Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II)
HQR01_01415	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HQR01_01420	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HQR01_01425	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HQR01_01430	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HQR01_01445	COG0275	rRNA processing
HQR01_01450	COG2001	Belongs to the MraZ family
HQR01_01485	COG2154	pterin-4-alpha-carbinolamine dehydratase
HQR01_01490	COG0531	amino acid
HQR01_01495	COG4133	protoheme IX ABC transporter activity
HQR01_01500	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HQR01_01505	COG0024	Methionine aminopeptidase
HQR01_01515	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HQR01_01530	COG0347	Belongs to the P(II) protein family
HQR01_01535	COG0174	glutamine synthetase
HQR01_01540	COG1104	cysteine desulfurase activity
HQR01_01570	COG0729	surface antigen
HQR01_01575	COG2935	proteasome-mediated ubiquitin-dependent protein catabolic process
HQR01_01580	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HQR01_01590	COG0805	protein transport
HQR01_01595	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HQR01_01600	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HQR01_01605	COG1386	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpA that pull DNA away from mid-cell into both cell halves
HQR01_01610	COG1354	Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves
HQR01_01615	COG1472	Belongs to the glycosyl hydrolase 3 family
HQR01_01625	COG0018	arginyl-trna synthetase
HQR01_01635	COG0761	Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)- butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP MEP pathway for isoprenoid precursor biosynthesis
HQR01_01640	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HQR01_01645	COG0328	RNA-DNA hybrid ribonuclease activity
HQR01_01650	COG3422	double-strand break repair
HQR01_01675	COG4964	Belongs to the GSP D family
HQR01_01705	COG1024	Enoyl-CoA hydratase
HQR01_01720	COG4771	TonB-dependent receptor
HQR01_01730	COG0457	Tetratricopeptide repeat
HQR01_01750	COG0542	response to heat
HQR01_01760	COG1960	acyl-CoA dehydrogenase activity
HQR01_01805	COG0064	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HQR01_01810	COG0154	amidase activity
HQR01_01815	COG0721	Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp- tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln)
HQR01_01830	COG0828	Belongs to the bacterial ribosomal protein bS21 family
HQR01_01835	COG0239	Important for reducing fluoride concentration in the cell, thus reducing its toxicity
HQR01_01880	COG1127	ABC transporter
HQR01_01885	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HQR01_01890	COG0525	valine-tRNA ligase activity
HQR01_01895	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HQR01_01915	COG0730	response to heat
HQR01_01925	COG1215	transferase activity, transferring glycosyl groups
HQR01_01930	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HQR01_01950	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HQR01_01970	COG3023	N-Acetylmuramoyl-L-alanine amidase
HQR01_01985	COG0564	pseudouridine synthase activity
HQR01_01990	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HQR01_02000	COG1473	amidohydrolase
HQR01_02030	COG1794	racemase activity, acting on amino acids and derivatives
HQR01_02035	COG1219	ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP
HQR01_02040	COG0740	serine-type endopeptidase activity
HQR01_02045	COG0740	serine-type endopeptidase activity
HQR01_02055	COG0154	amidase activity
HQR01_02070	COG4301	Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine
HQR01_02075	COG1262	PFAM Formylglycine-generating sulfatase enzyme
HQR01_02080	COG3706	GGDEF domain
HQR01_02085	COG3200	phospho-2-dehydro-3-deoxyheptonate aldolase
HQR01_02090	COG0612	Peptidase, M16
HQR01_02095	COG0694	Involved in iron-sulfur cluster biogenesis. Binds a 4Fe- 4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe S proteins. Could also act as a scaffold chaperone for damaged Fe S proteins
HQR01_02115	COG4957	zinc ion binding
HQR01_02130	COG0583	DNA-binding transcription factor activity
HQR01_02135	COG1253	flavin adenine dinucleotide binding
HQR01_02140	COG0319	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA
HQR01_02155	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HQR01_02165	COG2239	Acts as a magnesium transporter
HQR01_02170	COG3791	Glutathione-dependent formaldehyde-activating
HQR01_02190	COG2816	NAD+ diphosphatase activity
HQR01_02205	COG1194	a g-specific adenine glycosylase
HQR01_02225	COG1196	nuclear chromosome segregation
HQR01_02250	COG0776	regulation of translation
HQR01_02255	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HQR01_02260	COG0416	fatty acid biosynthetic process
HQR01_02265	COG0333	Belongs to the bacterial ribosomal protein bL32 family
HQR01_02275	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HQR01_02290	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HQR01_02310	COG1012	belongs to the aldehyde dehydrogenase family
HQR01_02315	COG0028	Belongs to the TPP enzyme family
HQR01_02335	COG0215	cysteine-tRNA ligase activity
HQR01_02340	COG3210	domain, Protein
HQR01_02365	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HQR01_02385	COG2169	Transcriptional regulator
HQR01_02385	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HQR01_02405	COG0712	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HQR01_02410	COG0056	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit
HQR01_02415	COG0224	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex
HQR01_02425	COG0055	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits
HQR01_02430	COG0355	proton-transporting ATP synthase activity, rotational mechanism
HQR01_02435	COG1505	serine-type exopeptidase activity
HQR01_02445	COG1207	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain
HQR01_02455	COG1028	Short-chain dehydrogenase reductase Sdr
HQR01_02475	COG1045	serine acetyltransferase
HQR01_02490	COG0150	phosphoribosylformylglycinamidine cyclo-ligase activity
HQR01_02495	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HQR01_02515	COG0105	UTP biosynthetic process
HQR01_02530	COG0260	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides
HQR01_02545	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
HQR01_02550	COG0030	16S rRNA (adenine(1518)-N(6)/adenine(1519)-N(6))-dimethyltransferase activity
HQR01_02555	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
HQR01_02570	COG3724	N-succinylarginine dihydrolase activity
HQR01_02595	COG1970	mechanosensitive ion channel activity
HQR01_02635	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HQR01_02645	COG4181	ATPase activity
HQR01_02650	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
HQR01_02660	COG4771	TonB-dependent receptor
HQR01_02680	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HQR01_02705	COG1305	Transglutaminase-like
HQR01_02715	COG2308	Evidence 4 Homologs of previously reported genes of
HQR01_02720	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HQR01_02720	COG0596	Alpha beta hydrolase
HQR01_02720	COG2226	methyltransferase
HQR01_02735	COG0556	nucleotide-excision repair
HQR01_02770	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HQR01_02775	COG1538	Outer membrane efflux protein
HQR01_02785	COG1136	(ABC) transporter
HQR01_02785	COG0577	efflux transmembrane transporter activity
HQR01_02795	COG1309	transcriptional regulator
HQR01_02805	COG0315	cyclic pyranopterin monophosphate synthase activity
HQR01_02860	COG5265	(ABC) transporter
HQR01_02865	COG0659	secondary active sulfate transmembrane transporter activity
HQR01_02875	COG1220	this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis
HQR01_02880	COG5405	Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery
HQR01_02910	COG0629	single-stranded DNA binding
HQR01_02935	COG1999	signal sequence binding
HQR01_02940	COG2983	Belongs to the UPF0260 family
HQR01_02955	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HQR01_02955	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HQR01_02965	COG2885	chlorophyll binding
HQR01_02985	COG1448	Aminotransferase
HQR01_03040	COG0436	Aminotransferase
HQR01_03045	COG3243	poly(R)-hydroxyalkanoic acid synthase
HQR01_03085	COG2201	protein-glutamate methylesterase activity
HQR01_03090	COG0784	Response regulator, receiver
HQR01_03095	COG3920	Histidine kinase
HQR01_03115	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HQR01_03125	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HQR01_03135	COG0351	phosphomethylpyrimidine kinase
HQR01_03135	COG0352	thiamine-phosphate diphosphorylase activity
HQR01_03135	COG0819	Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway
HQR01_03150	COG2360	Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine
HQR01_03155	COG4765	Protein conserved in bacteria
HQR01_03175	COG0318	PFAM AMP-dependent synthetase and ligase
HQR01_03210	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HQR01_03220	COG0535	radical SAM domain protein
HQR01_03230	COG2226	methyltransferase
HQR01_03235	COG1091	dTDP-4-dehydrorhamnose reductase activity
HQR01_03260	COG2853	Lipoprotein
HQR01_03270	COG0408	coproporphyrinogen oxidase activity
HQR01_03280	COG0290	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins
HQR01_03285	COG0471	metal ion transport
HQR01_03310	COG2311	Membrane
HQR01_03315	COG0484	heat shock protein binding
HQR01_03325	COG2885	chlorophyll binding
HQR01_03330	COG0823	Involved in the tonB-independent uptake of proteins
HQR01_03350	COG0824	Thioesterase
HQR01_03360	COG0140	phosphoribosyl-ATP diphosphatase activity
HQR01_03365	COG0107	imidazoleglycerol-phosphate synthase activity
HQR01_03370	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
HQR01_03375	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HQR01_03380	COG0131	Imidazoleglycerol-phosphate dehydratase
HQR01_03395	COG0194	GDP metabolic process
HQR01_03405	COG1028	Short-chain dehydrogenase reductase Sdr
HQR01_03410	COG1960	acyl-CoA dehydrogenase activity
HQR01_03415	COG1960	acyl-CoA dehydrogenase activity
HQR01_03420	COG1028	Short-chain dehydrogenase reductase Sdr
HQR01_03425	COG2211	Major facilitator Superfamily
HQR01_03445	COG2171	N-acyltransferase activity
HQR01_03500	COG0657	acetylesterase activity
HQR01_03520	COG0625	glutathione transferase activity
HQR01_03540	COG2824	Alkylphosphonate utilization operon protein PhnA
HQR01_03545	COG1671	Belongs to the UPF0178 family
HQR01_03550	COG0251	oxidation-reduction process
HQR01_03600	COG0422	Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction
HQR01_03620	COG0583	DNA-binding transcription factor activity
HQR01_03640	COG2072	flavoprotein involved in K transport
HQR01_03650	COG0583	DNA-binding transcription factor activity
HQR01_03655	COG0778	Nitroreductase
HQR01_03675	COG0293	Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit
HQR01_03680	COG3474	cytochrome
HQR01_03695	COG1446	asparaginase
HQR01_03700	COG0456	acetyltransferase
HQR01_03715	COG3220	belongs to the UPF0276 family
HQR01_03760	COG0821	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate
HQR01_03780	COG2989	Protein conserved in bacteria
HQR01_03795	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HQR01_03800	COG2255	four-way junction helicase activity
HQR01_03815	COG0632	four-way junction helicase activity
HQR01_03820	COG0082	Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system
HQR01_03840	COG0450	alkyl hydroperoxide reductase
HQR01_03845	COG3634	alkyl hydroperoxide reductase activity
HQR01_03850	COG0376	Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity
HQR01_03880	COG1952	One of the proteins required for the normal export of preproteins out of the cell cytoplasm. It is a molecular chaperone that binds to a subset of precursor proteins, maintaining them in a translocation-competent state. It also specifically binds to its receptor SecA
HQR01_03885	COG0728	peptidoglycan biosynthetic process
HQR01_03890	COG0180	Tryptophanyl-tRNA synthetase
HQR01_03900	COG0756	dUTP diphosphatase activity
HQR01_03905	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HQR01_03915	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HQR01_03920	COG2226	methyltransferase
HQR01_03925	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HQR01_03945	COG1062	S-(hydroxymethyl)glutathione dehydrogenase activity
HQR01_03965	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
HQR01_03970	COG3541	Predicted nucleotidyltransferase
HQR01_03975	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HQR01_03975	COG2813	Specifically methylates the guanine in position
HQR01_03985	COG2021	Transfers an acetyl group from acetyl-CoA to L- homoserine, forming acetyl-L-homoserine
HQR01_03990	COG0079	Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily
HQR01_03995	COG0287	Prephenate dehydrogenase
HQR01_04005	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HQR01_04030	COG2884	Cell division ATP-binding protein ftsE
HQR01_04085	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
HQR01_04110	COG0300	oxidoreductase activity
HQR01_04130	COG0717	Belongs to the dCTP deaminase family
HQR01_04140	COG3268	Saccharopine dehydrogenase
HQR01_04145	COG4771	TonB-dependent receptor
HQR01_04175	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HQR01_04200	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HQR01_04205	COG0456	acetyltransferase
HQR01_04215	COG0625	glutathione transferase activity
HQR01_04220	COG2070	2-Nitropropane dioxygenase
HQR01_04225	COG1942	4-Oxalocrotonate Tautomerase
HQR01_04235	COG0625	glutathione transferase activity
HQR01_04275	COG1024	Enoyl-CoA hydratase
HQR01_04315	COG2095	MarC family integral membrane protein
HQR01_04325	COG0190	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate
HQR01_04335	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HQR01_04345	COG1028	Short-chain dehydrogenase reductase Sdr
HQR01_04365	COG2841	Protein conserved in bacteria
HQR01_04385	COG1372	Participates in initiation and elongation during chromosome replication
HQR01_04385	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HQR01_04400	COG3706	GGDEF domain
HQR01_04405	COG5001	Diguanylate cyclase
HQR01_04405	COG3706	GGDEF domain
HQR01_04405	COG2203	Gaf domain
HQR01_04405	COG4251	negative regulation of phosphorylation
HQR01_04410	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HQR01_04410	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HQR01_04420	COG3104	oligopeptide transport
HQR01_04440	COG1120	ATPase activity
HQR01_04455	COG1131	(ABC) transporter
HQR01_04465	COG0312	modulator of DNA gyrase
HQR01_04490	COG2271	Major facilitator Superfamily
HQR01_04500	COG0518	GMP synthase (glutamine-hydrolyzing) activity
HQR01_04500	COG0519	Catalyzes the synthesis of GMP from XMP
HQR01_04505	COG0318	PFAM AMP-dependent synthetase and ligase
HQR01_04510	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HQR01_04525	COG1760	l-serine dehydratase
HQR01_04535	COG0628	permease
HQR01_04580	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HQR01_04590	COG1960	acyl-CoA dehydrogenase activity
HQR01_04605	COG1125	glycine betaine transport
HQR01_04625	COG0682	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins
HQR01_04630	COG0318	PFAM AMP-dependent synthetase and ligase
HQR01_04635	COG2844	Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen
HQR01_04640	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HQR01_04645	COG0352	thiamine-phosphate diphosphorylase activity
HQR01_04650	COG1674	ftsk spoiiie
HQR01_04655	COG0372	Belongs to the citrate synthase family
HQR01_04660	COG0372	Belongs to the citrate synthase family
HQR01_04670	COG4206	TonB-dependent receptor
HQR01_04680	COG1522	sequence-specific DNA binding
HQR01_04685	COG0686	Belongs to the AlaDH PNT family
HQR01_04690	COG3706	GGDEF domain
HQR01_04695	COG3706	GGDEF domain
HQR01_04710	COG0006	proline dipeptidase activity
HQR01_04730	COG0745	RESPONSE REGULATOR receiver
HQR01_04735	COG2205	protein histidine kinase activity
HQR01_04745	COG0433	COG0433 Predicted ATPase
HQR01_04750	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HQR01_04755	COG0564	pseudouridine synthase activity
HQR01_04765	COG0267	Belongs to the bacterial ribosomal protein bL33 family
HQR01_04785	COG0807	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HQR01_04785	COG0108	Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate
HQR01_04815	COG0514	ATP-dependent DNA helicase (RecQ)
HQR01_04835	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HQR01_04840	COG0183	Belongs to the thiolase family
HQR01_04845	COG3777	bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding
HQR01_04860	COG3186	Phenylalanine-4-hydroxylase
HQR01_04875	COG1968	undecaprenyl-diphosphatase activity
HQR01_04880	COG1132	(ABC) transporter
HQR01_04895	COG0183	Belongs to the thiolase family
HQR01_04925	COG0070	glutamate synthase
HQR01_04925	COG0067	glutamate synthase
HQR01_04925	COG0069	glutamate synthase activity
HQR01_04935	COG1024	Enoyl-CoA hydratase
HQR01_04940	COG1028	Short-chain dehydrogenase reductase Sdr
HQR01_04950	COG0692	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
HQR01_04955	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HQR01_04985	COG0495	leucyl-tRNA aminoacylation
HQR01_05000	COG1028	Short-chain dehydrogenase reductase Sdr
HQR01_05020	COG2226	methyltransferase
HQR01_05025	COG0766	Cell wall formation. Adds enolpyruvyl to UDP-N- acetylglucosamine
HQR01_05030	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HQR01_05035	COG2268	Band 7 protein
HQR01_05060	COG0739	heme binding
HQR01_05065	COG2833	Protein of unknown function (DUF455)
HQR01_05070	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HQR01_05075	COG1391	[glutamine synthetase]-adenylyl-L-tyrosine phosphorylase
HQR01_05085	COG2957	Belongs to the agmatine deiminase family
HQR01_05100	COG0441	Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr)
HQR01_05105	COG0625	glutathione transferase activity
HQR01_05110	COG3540	Alkaline phosphatase
HQR01_05130	COG4269	membrane
HQR01_05150	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HQR01_05165	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HQR01_05170	COG4152	abc transporter atp-binding protein
HQR01_05185	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HQR01_05200	COG0776	regulation of translation
HQR01_05205	COG2188	Transcriptional regulator
HQR01_05210	COG3104	oligopeptide transport
HQR01_05215	COG1228	amidohydrolase
HQR01_05220	COG1228	amidohydrolase
HQR01_05225	COG0545	Peptidyl-prolyl cis-trans isomerase
HQR01_05235	COG1024	Enoyl-CoA hydratase
HQR01_05250	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HQR01_05260	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HQR01_05265	COG0138	bifunctional purine biosynthesis protein purh
HQR01_05295	COG1132	(ABC) transporter
HQR01_05350	COG0501	Belongs to the peptidase M48B family
HQR01_05365	COG3275	phosphorelay sensor kinase activity
HQR01_05370	COG3279	Response regulator of the LytR AlgR family
HQR01_05375	COG1017	nitric oxide dioxygenase activity
HQR01_05375	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HQR01_05380	COG1959	2 iron, 2 sulfur cluster binding
HQR01_05400	COG0590	tRNA wobble adenosine to inosine editing
HQR01_05405	COG0227	Belongs to the bacterial ribosomal protein bL28 family
HQR01_05425	COG1570	exodeoxyribonuclease VII activity
HQR01_05430	COG0151	Belongs to the GarS family
HQR01_05440	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HQR01_05460	COG0316	Belongs to the HesB IscA family
HQR01_05470	COG2151	metal-sulfur cluster biosynthetic enzyme
HQR01_05475	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HQR01_05480	COG0719	Fe-S assembly protein
HQR01_05485	COG0396	ATPase activity
HQR01_05495	COG0719	Fe-S assembly protein
HQR01_05510	COG0167	dihydroorotate dehydrogenase activity
HQR01_05515	COG0405	Gamma-glutamyltransferase
HQR01_05535	COG2022	thiamine diphosphate biosynthetic process
HQR01_05545	COG1612	heme a metabolic process
HQR01_05550	COG1324	tolerance protein
HQR01_05555	COG0102	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly
HQR01_05560	COG0103	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
HQR01_05590	COG3275	phosphorelay sensor kinase activity
HQR01_05595	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HQR01_05595	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
HQR01_05600	COG2518	Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and or degradation of damaged proteins
HQR01_05605	COG1538	Outer membrane efflux protein
HQR01_05615	COG0823	Involved in the tonB-independent uptake of proteins
HQR01_05615	COG1506	peptidase
HQR01_05630	COG0517	IMP dehydrogenase activity
HQR01_05635	COG0316	Belongs to the HesB IscA family
HQR01_05645	COG3409	Peptidoglycan-binding domain 1 protein
HQR01_05645	COG3773	Cell wall hydrolase
HQR01_05660	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HQR01_05665	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HQR01_05670	COG0237	dephospho-CoA kinase activity
HQR01_05675	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HQR01_05680	COG0424	maF-like protein
HQR01_05685	COG1806	Bifunctional serine threonine kinase and phosphorylase involved in the regulation of the
HQR01_05690	COG0407	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III
HQR01_05700	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
HQR01_05720	COG0486	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34
HQR01_05725	COG0445	tRNA wobble uridine modification
HQR01_05730	COG0357	Ribosomal RNA small subunit methyltransferase G
HQR01_05750	COG1956	GAF domain-containing protein
HQR01_05760	COG1960	acyl-CoA dehydrogenase activity
HQR01_05765	COG0009	L-threonylcarbamoyladenylate synthase
HQR01_05780	COG1329	Transcriptional regulator
HQR01_05785	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
HQR01_05800	COG0739	heme binding
HQR01_05800	COG0741	lytic transglycosylase activity
HQR01_05800	COG1196	nuclear chromosome segregation
HQR01_05805	COG0113	porphobilinogen synthase activity
HQR01_05825	COG1872	DUF167
HQR01_05835	COG0438	transferase activity, transferring glycosyl groups
HQR01_05865	COG0438	transferase activity, transferring glycosyl groups
HQR01_05875	COG0318	PFAM AMP-dependent synthetase and ligase
HQR01_05885	COG0739	heme binding
HQR01_05890	COG1057	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD)
HQR01_05895	COG0799	negative regulation of ribosome biogenesis
HQR01_05900	COG1576	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA
HQR01_05910	COG0793	Belongs to the peptidase S41A family
HQR01_05920	COG2941	Oxygenase that introduces the hydroxyl group at carbon five of 2-nonaprenyl-3-methyl-6-methoxy-1,4-benzoquinol resulting in the formation of 2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4- benzoquinol
HQR01_05930	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HQR01_05935	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HQR01_05940	COG1295	ribonuclease BN
HQR01_05945	COG0484	heat shock protein binding
HQR01_05950	COG0259	pyridoxamine-phosphate oxidase activity
HQR01_05960	COG0384	phenazine biosynthesis protein PhzF
HQR01_05975	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HQR01_05980	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
HQR01_05985	COG0482	sulfurtransferase activity
HQR01_06015	COG2733	membrane
HQR01_06035	COG2086	electron transfer activity
HQR01_06045	COG0045	succinate-CoA ligase (ADP-forming) activity
HQR01_06050	COG0483	inositol monophosphate 1-phosphatase activity
HQR01_06055	COG2885	chlorophyll binding
HQR01_06060	COG1253	flavin adenine dinucleotide binding
HQR01_06075	COG0588	phosphoglycerate mutase activity
HQR01_06080	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HQR01_06085	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HQR01_06100	COG0196	riboflavin kinase activity
HQR01_06110	COG0060	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile)
HQR01_06115	COG0597	This protein specifically catalyzes the removal of signal peptides from prolipoproteins
HQR01_06160	COG0501	Belongs to the peptidase M48B family
HQR01_06170	COG0308	aminopeptidase N
HQR01_06185	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HQR01_06190	COG2857	Cytochrome c1
HQR01_06190	COG1290	Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
HQR01_06195	COG0503	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis
HQR01_06215	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
HQR01_06220	COG1192	Involved in chromosome partitioning
HQR01_06235	COG1201	RNA secondary structure unwinding
HQR01_06285	COG1494	fructose-1,6-bisphosphatase
HQR01_06300	COG0483	inositol monophosphate 1-phosphatase activity
HQR01_06305	COG1028	Short-chain dehydrogenase reductase Sdr
HQR01_06315	COG0291	Belongs to the bacterial ribosomal protein bL35 family
HQR01_06320	COG0292	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit
HQR01_06340	COG0016	Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily
HQR01_06345	COG0072	phenylalanine-tRNA ligase activity
HQR01_06355	COG4221	oxidoreductase activity
HQR01_06360	COG4108	Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP
HQR01_06365	COG2267	carboxylic ester hydrolase activity
HQR01_06380	COG0347	Belongs to the P(II) protein family
HQR01_06385	COG0004	ammonium transporteR
HQR01_06390	COG4771	TonB-dependent receptor
HQR01_06410	COG1473	amidohydrolase
HQR01_06420	COG1278	Cold shock
HQR01_06425	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HQR01_06430	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HQR01_06435	COG1281	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress
HQR01_06445	COG0603	Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0))
HQR01_06455	COG2032	superoxide dismutase activity
HQR01_06480	COG1238	metal cluster binding
HQR01_06495	COG2084	Dehydrogenase
HQR01_06500	COG0583	DNA-binding transcription factor activity
HQR01_06510	COG0156	8-amino-7-oxononanoate synthase activity
HQR01_06515	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HQR01_06580	COG3483	tryptophan 2,3-dioxygenase activity
HQR01_06585	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
HQR01_06610	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HQR01_06625	COG1250	3-hydroxyacyl-CoA dehydrogenase
HQR01_06635	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HQR01_06640	COG0280	phosphate acetyltransferase
HQR01_06640	COG0281	malic enzyme
HQR01_06655	COG0220	tRNA (guanine-N7-)-methyltransferase activity
HQR01_06660	COG0730	response to heat
HQR01_06675	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
HQR01_06680	COG1137	ATPase activity
HQR01_06690	COG0312	modulator of DNA gyrase
HQR01_06695	COG0668	transmembrane transport
HQR01_06700	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HQR01_06710	COG0124	histidyl-tRNA synthetase
HQR01_06715	COG0216	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA
HQR01_06720	COG2890	protein-(glutamine-N5) methyltransferase activity
HQR01_06730	COG0815	Transfers the fatty acyl group on membrane lipoproteins
HQR01_06735	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
HQR01_06740	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HQR01_06750	COG2070	2-Nitropropane dioxygenase
HQR01_06785	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HQR01_06790	COG3264	Mechanosensitive ion channel
HQR01_06790	COG3096	Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division
HQR01_06795	COG3920	Histidine kinase
HQR01_06800	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HQR01_06800	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HQR01_06845	COG0459	protein refolding
HQR01_06850	COG0234	Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter
HQR01_06855	COG0534	Mate efflux family protein
HQR01_06865	COG0739	heme binding
HQR01_06890	COG4964	Belongs to the GSP D family
HQR01_06960	COG0583	DNA-binding transcription factor activity
HQR01_06970	COG0488	(ABC) transporter
HQR01_06990	COG0640	Transcriptional regulator
HQR01_06995	COG0450	alkyl hydroperoxide reductase
HQR01_07010	COG2391	methyltransferase activity
HQR01_07020	COG0730	response to heat
HQR01_07025	COG1271	oxidase subunit
HQR01_07030	COG1294	oxidase, subunit
HQR01_07070	COG2202	Pas domain
HQR01_07070	COG2205	protein histidine kinase activity
HQR01_07075	COG1522	sequence-specific DNA binding
HQR01_07085	COG2267	carboxylic ester hydrolase activity
HQR01_07090	COG0439	Biotin carboxylase
HQR01_07095	COG0511	ligase activity, forming carbon-carbon bonds
HQR01_07105	COG1937	Protein conserved in bacteria
HQR01_07110	COG2132	Multicopper oxidase
HQR01_07130	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HQR01_07145	COG1862	Preprotein translocase
HQR01_07150	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HQR01_07155	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HQR01_07160	COG0438	transferase activity, transferring glycosyl groups
HQR01_07180	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HQR01_07200	COG2205	protein histidine kinase activity
HQR01_07210	COG0287	Prephenate dehydrogenase
HQR01_07210	COG1605	Chorismate mutase
HQR01_07215	COG0142	geranyltranstransferase activity
HQR01_07220	COG0667	Aldo Keto reductase
HQR01_07225	COG1643	Atp-dependent helicase
HQR01_07240	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HQR01_07245	COG0718	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection
HQR01_07255	COG0776	regulation of translation
HQR01_07265	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HQR01_07275	COG1522	sequence-specific DNA binding
HQR01_07290	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HQR01_07300	COG0688	phosphatidylethanolamine metabolic process
HQR01_07315	COG0052	Belongs to the universal ribosomal protein uS2 family
HQR01_07320	COG0264	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome
HQR01_07335	COG0384	phenazine biosynthesis protein PhzF
HQR01_07370	COG0528	UMP kinase activity
HQR01_07375	COG0233	cytoplasmic translational termination
HQR01_07380	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HQR01_07390	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HQR01_07395	COG0750	zinc metalloprotease
HQR01_07410	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HQR01_07415	COG0254	rRNA binding
HQR01_07440	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HQR01_07450	COG2332	Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH
HQR01_07455	COG1138	Cytochrome C-type biogenesis protein
HQR01_07465	COG3088	subunit of a heme lyase
HQR01_07470	COG4235	cytochrome complex assembly
HQR01_07475	COG3158	transport of potassium into the cell
HQR01_07480	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
HQR01_07485	COG0583	DNA-binding transcription factor activity
HQR01_07490	COG2917	probably involved in intracellular septation
HQR01_07495	COG0552	protein localization to endoplasmic reticulum
HQR01_07500	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HQR01_07505	COG0253	Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan
HQR01_07510	COG3300	MHYT domain
HQR01_07510	COG5001	Diguanylate cyclase
HQR01_07520	COG0028	Belongs to the TPP enzyme family
HQR01_07535	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HQR01_07545	COG0583	DNA-binding transcription factor activity
HQR01_07550	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
HQR01_07555	COG0173	Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp Asn)
HQR01_07570	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HQR01_07575	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HQR01_07580	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HQR01_07600	COG0582	viral genome integration into host DNA
HQR01_07610	COG0741	lytic transglycosylase activity
HQR01_07680	COG4227	nucleotidyltransferase activity
HQR01_07700	COG0629	single-stranded DNA binding
HQR01_07720	COG4974	Belongs to the 'phage' integrase family
HQR01_07730	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HQR01_07745	COG2059	Chromate
HQR01_07750	COG0629	single-stranded DNA binding
HQR01_07775	COG3550	peptidyl-serine autophosphorylation
HQR01_07780	COG3620	sequence-specific DNA binding
HQR01_07860	COG0681	Belongs to the peptidase S26 family
HQR01_07935	COG2226	methyltransferase
HQR01_07980	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HQR01_07985	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HQR01_08000	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HQR01_08045	COG2226	methyltransferase
HQR01_08065	COG2132	Multicopper oxidase
HQR01_08135	COG2989	Protein conserved in bacteria
HQR01_08140	COG1136	(ABC) transporter
HQR01_08155	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HQR01_08180	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HQR01_08185	COG0001	glutamate-1-semialdehyde 2,1-aminomutase activity
HQR01_08190	COG0174	glutamine synthetase
HQR01_08215	COG1177	transmembrane transport
HQR01_08225	COG1012	belongs to the aldehyde dehydrogenase family
HQR01_08230	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
HQR01_08245	COG0010	Belongs to the arginase family
HQR01_08255	COG0625	glutathione transferase activity
HQR01_08265	COG0697	spore germination
HQR01_08270	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HQR01_08280	COG1189	Ribosomal RNA methyltransferase RrmJ FtsJ
HQR01_08285	COG3800	Transcriptional regulator
HQR01_08285	COG1396	sequence-specific DNA binding
HQR01_08300	COG0346	lactoylglutathione lyase activity
HQR01_08305	COG1024	Enoyl-CoA hydratase
HQR01_08315	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HQR01_08315	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HQR01_08320	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HQR01_08330	COG4770	biotin carboxylase activity
HQR01_08335	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HQR01_08340	COG1878	Catalyzes the hydrolysis of N-formyl-L-kynurenine to L- kynurenine, the second step in the kynurenine pathway of tryptophan degradation
HQR01_08345	COG3104	oligopeptide transport
HQR01_08350	COG0337	Catalyzes the conversion of 3-deoxy-D-arabino- heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ)
HQR01_08355	COG0703	Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate
HQR01_08365	COG4974	Belongs to the 'phage' integrase family
HQR01_08370	COG0825	malonyl-CoA metabolic process
HQR01_08390	COG0494	nUDIX hydrolase
HQR01_08405	COG0302	gtp cyclohydrolase
HQR01_08415	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HQR01_08415	COG0678	peroxiredoxin activity
HQR01_08425	COG0499	May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine
HQR01_08430	COG2205	protein histidine kinase activity
HQR01_08435	COG0802	atpase or kinase
HQR01_08445	COG1208	COG1208 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis translation initiation factor 2B, gamma epsilon subunits eIF-2Bgamma eIF-2Bepsilon
HQR01_08455	COG1074	ATP-dependent DNA helicase activity
HQR01_08465	COG0483	inositol monophosphate 1-phosphatase activity
HQR01_08470	COG1364	Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis the synthesis of N- acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate
HQR01_08480	COG0653	protein targeting
HQR01_08485	COG0456	acetyltransferase
HQR01_08500	COG0061	Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP
HQR01_08505	COG5001	Diguanylate cyclase
HQR01_08505	COG3300	MHYT domain
HQR01_08510	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HQR01_08525	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HQR01_08530	COG1280	lysine exporter protein (LysE YggA)
HQR01_08535	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HQR01_08550	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
HQR01_08580	COG2211	Major facilitator Superfamily
HQR01_08590	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HQR01_08610	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HQR01_08615	COG0126	phosphoglycerate kinase activity
HQR01_08625	COG3588	fructose-bisphosphate aldolase
HQR01_08635	COG0352	thiamine-phosphate diphosphorylase activity
HQR01_08645	COG0231	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase
HQR01_08655	COG0483	inositol monophosphate 1-phosphatase activity
HQR01_08670	COG3273	potassium ion transport
HQR01_08670	COG0471	metal ion transport
HQR01_08675	COG1473	amidohydrolase
HQR01_08700	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HQR01_08705	COG2205	protein histidine kinase activity
HQR01_08705	COG2198	Histidine kinase
HQR01_08705	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HQR01_08705	COG0784	Response regulator, receiver
HQR01_08710	COG2204	response regulator
HQR01_08735	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
HQR01_08740	COG0531	amino acid
HQR01_08760	COG0587	DNA-directed DNA polymerase activity
HQR01_08765	COG1280	lysine exporter protein (LysE YggA)
HQR01_08775	COG0745	RESPONSE REGULATOR receiver
HQR01_08780	COG0704	Plays a role in the regulation of phosphate uptake
HQR01_08785	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HQR01_08795	COG0573	inorganic phosphate transmembrane transporter activity
HQR01_08805	COG3746	phosphate-selective porin O and P
HQR01_08810	COG5002	protein histidine kinase activity
HQR01_08825	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HQR01_08845	COG3618	amidohydrolase
HQR01_08860	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HQR01_08870	COG0596	Alpha beta hydrolase
HQR01_08885	COG0059	Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol- acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3- dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3- hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate
HQR01_08900	COG0028	Belongs to the TPP enzyme family
HQR01_08905	COG0324	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A)
HQR01_08910	COG0560	Phosphoserine phosphatase
HQR01_08935	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HQR01_08945	COG1250	3-hydroxyacyl-CoA dehydrogenase
HQR01_08945	COG1024	Enoyl-CoA hydratase
HQR01_08955	COG1722	exodeoxyribonuclease VII activity
HQR01_08965	COG0669	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate
HQR01_08975	COG0809	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA)
HQR01_08980	COG1309	transcriptional regulator
HQR01_08985	COG3670	oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
HQR01_08990	COG1131	(ABC) transporter
HQR01_08995	COG0842	Transport permease protein
HQR01_09005	COG0343	queuine tRNA-ribosyltransferase activity
HQR01_09020	COG0522	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit
HQR01_09040	COG1327	Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR- boxes
HQR01_09050	COG0112	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism
HQR01_09055	COG0698	ribose 5-phosphate isomerase
HQR01_09065	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HQR01_09070	COG0358	DNA primase activity
HQR01_09080	COG0505	Belongs to the CarA family
HQR01_09095	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HQR01_09130	COG0148	phosphopyruvate hydratase activity
HQR01_09155	COG0054	6,7-dimethyl-8-ribityllumazine synthase activity
HQR01_09180	COG0772	Belongs to the SEDS family
HQR01_09205	COG0323	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
HQR01_09215	COG2030	dehydratase
HQR01_09230	COG0012	GTP binding
HQR01_09245	COG0193	aminoacyl-tRNA hydrolase activity
HQR01_09250	COG1825	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance
HQR01_09265	COG0752	glycyl-tRNA synthetase alpha subunit
HQR01_09270	COG0751	glycine-tRNA ligase activity
HQR01_09275	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HQR01_09275	COG0574	Belongs to the PEP-utilizing enzyme family
HQR01_09280	COG2226	methyltransferase
HQR01_09290	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HQR01_09295	COG0789	Transcriptional regulator
HQR01_09300	COG1960	acyl-CoA dehydrogenase activity
HQR01_09320	COG2814	Major facilitator Superfamily
HQR01_09330	COG0162	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr)
HQR01_09340	COG3876	Protein conserved in bacteria
HQR01_09350	COG2814	Major facilitator Superfamily
HQR01_09355	COG3739	integral membrane protein
HQR01_09370	COG0840	transmembrane signaling receptor activity
HQR01_09375	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HQR01_09385	COG0187	DNA topoisomerase II activity
HQR01_09395	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HQR01_09400	COG0792	nuclease activity
HQR01_09405	COG0189	ligase activity
HQR01_09410	COG0586	Pfam SNARE associated Golgi protein
HQR01_09415	COG4974	Belongs to the 'phage' integrase family
HQR01_09420	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HQR01_09430	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HQR01_09435	COG0689	Phosphorolytic exoribonuclease that removes nucleotide residues following the -CCA terminus of tRNA and adds nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates
HQR01_09440	COG1420	regulation of RNA biosynthetic process
HQR01_09445	COG0576	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
HQR01_09470	COG0443	Heat shock 70 kDa protein
HQR01_09475	COG0484	heat shock protein binding
HQR01_09480	COG1752	Esterase of the alpha-beta hydrolase superfamily
HQR01_09505	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HQR01_09515	COG0442	prolyl-tRNA aminoacylation
HQR01_09520	COG2234	aminopeptidase activity
HQR01_09525	COG0557	exoribonuclease II activity
HQR01_09535	COG0508	dehydrogenase complex catalyzes the overall conversion of
HQR01_09545	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HQR01_09570	COG2951	lytic endotransglycosylase activity
HQR01_09580	COG1686	Belongs to the peptidase S11 family
HQR01_09585	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HQR01_09600	COG0084	hydrolase, TatD family'
HQR01_09605	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
HQR01_09605	COG0321	lipoyl(octanoyl) transferase activity
HQR01_09615	COG3956	TIGRFAM MazG family protein
HQR01_09620	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HQR01_09625	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HQR01_09630	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HQR01_09635	COG1923	regulation of RNA biosynthetic process
HQR01_09640	COG2204	response regulator
HQR01_09645	COG5000	phosphorelay sensor kinase activity
HQR01_09655	COG3852	Histidine kinase
HQR01_09665	COG1211	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase activity
HQR01_09665	COG0245	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity
HQR01_09670	COG1546	Belongs to the CinA family
HQR01_09670	COG1058	Belongs to the CinA family
HQR01_09675	COG2867	negative regulation of translational initiation
HQR01_09680	COG0320	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives
HQR01_09685	COG0288	reversible hydration of carbon dioxide
HQR01_09700	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HQR01_09715	COG1206	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs
HQR01_09745	COG0508	dehydrogenase complex catalyzes the overall conversion of
HQR01_09745	COG0022	dehydrogenase e1 component
HQR01_09750	COG1071	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor
HQR01_09785	COG0596	Alpha beta hydrolase
HQR01_09790	COG2814	Major facilitator Superfamily
HQR01_09805	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HQR01_09815	COG0071	Belongs to the small heat shock protein (HSP20) family
HQR01_09820	COG0504	CTP synthase activity
HQR01_09830	COG0149	triose-phosphate isomerase activity
HQR01_09840	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HQR01_09845	COG3698	Phosphodiester glycosidase
HQR01_09860	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HQR01_09865	COG0134	indole-3-glycerol-phosphate synthase activity
HQR01_09870	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HQR01_09875	COG0658	competence protein
HQR01_09875	COG2333	competence protein COMEC
HQR01_09880	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HQR01_09885	COG0372	Belongs to the citrate synthase family
HQR01_09890	COG2205	protein histidine kinase activity
HQR01_09920	COG1521	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis
HQR01_09930	COG1007	ATP synthesis coupled electron transport
HQR01_09945	COG0713	ATP synthesis coupled electron transport
HQR01_09955	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HQR01_09960	COG1005	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone
HQR01_09970	COG1034	ATP synthesis coupled electron transport
HQR01_09980	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
HQR01_09990	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
HQR01_09995	COG0649	NAD binding
HQR01_10005	COG0852	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HQR01_10010	COG0377	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HQR01_10015	COG0838	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HQR01_10025	COG1012	belongs to the aldehyde dehydrogenase family
HQR01_10055	COG0454	-acetyltransferase
HQR01_10075	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
HQR01_10080	COG0860	N-Acetylmuramoyl-L-alanine amidase
HQR01_10085	COG1530	ribonuclease E activity
HQR01_10090	COG2226	methyltransferase
HQR01_10115	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
HQR01_10125	COG3409	Peptidoglycan-binding domain 1 protein
HQR01_10125	COG3267	Type II secretory pathway component ExeA
HQR01_10145	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HQR01_10160	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HQR01_10165	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HQR01_10165	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HQR01_10175	COG0129	dihydroxy-acid dehydratase activity
HQR01_10185	COG1947	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol
HQR01_10210	COG0521	Mo-molybdopterin cofactor biosynthetic process
HQR01_10240	COG0318	PFAM AMP-dependent synthetase and ligase
HQR01_10255	COG0386	Belongs to the glutathione peroxidase family
HQR01_10270	COG1136	(ABC) transporter
HQR01_10280	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HQR01_10285	COG4221	oxidoreductase activity
HQR01_10295	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HQR01_10300	COG0415	Belongs to the DNA photolyase family
HQR01_10310	COG1013	pyruvate-flavodoxin oxidoreductase activity
HQR01_10315	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HQR01_10315	COG0674	pyruvate-flavodoxin oxidoreductase activity
HQR01_10325	COG1051	belongs to the nudix hydrolase family
HQR01_10350	COG1028	Short-chain dehydrogenase reductase Sdr
HQR01_10355	COG2321	neutral zinc metallopeptidase
HQR01_10365	COG3682	Transcriptional regulator
HQR01_10370	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HQR01_10375	COG0531	amino acid
HQR01_10425	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
HQR01_10435	COG1028	Short-chain dehydrogenase reductase Sdr
HQR01_10440	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HQR01_10445	COG2264	protein methyltransferase activity
HQR01_10475	COG0272	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA
HQR01_10495	COG3706	GGDEF domain
HQR01_10500	COG2199	diguanylate cyclase activity
HQR01_10505	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HQR01_10515	COG0861	Integral membrane protein TerC family
HQR01_10525	COG0263	Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate
HQR01_10535	COG0014	Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5- carboxylate
HQR01_10545	COG0753	catalase activity
HQR01_10580	COG0328	RNA-DNA hybrid ribonuclease activity
HQR01_10585	COG0481	GTPase activity
HQR01_10590	COG5001	Diguanylate cyclase
HQR01_10595	COG5001	Diguanylate cyclase
HQR01_10600	COG0493	'glutamate synthase
HQR01_10625	COG0604	alcohol dehydrogenase
HQR01_10625	COG1028	Short-chain dehydrogenase reductase Sdr
HQR01_10625	COG3321	synthase
HQR01_10630	COG0154	amidase activity
HQR01_10660	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HQR01_10670	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HQR01_10675	COG0625	glutathione transferase activity
HQR01_10680	COG2354	Protein conserved in bacteria
HQR01_10685	COG0360	Binds together with S18 to 16S ribosomal RNA
HQR01_10690	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HQR01_10695	COG0359	binds to the 23S rRNA
HQR01_10700	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HQR01_10705	COG1028	Short-chain dehydrogenase reductase Sdr
HQR01_10710	COG0189	ligase activity
HQR01_10715	COG4067	protein conserved in archaea
HQR01_10715	COG0189	ligase activity
HQR01_10735	COG2267	carboxylic ester hydrolase activity
HQR01_10755	COG1566	PFAM secretion protein HlyD family protein
HQR01_10760	COG2814	Major facilitator Superfamily
HQR01_10770	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HQR01_10780	COG0335	large ribosomal subunit rRNA binding
HQR01_10785	COG0336	Belongs to the RNA methyltransferase TrmD family
HQR01_10810	COG0806	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes
HQR01_10815	COG0228	four-way junction DNA binding
HQR01_10820	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HQR01_10835	COG0128	3-phosphoshikimate 1-carboxyvinyltransferase activity
HQR01_10845	COG0283	belongs to the cytidylate kinase family. Type 1 subfamily
HQR01_10855	COG3647	Membrane
HQR01_10860	COG0539	negative regulation of cytoplasmic translation
HQR01_10865	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HQR01_10875	COG3321	synthase
HQR01_10875	COG1028	Short-chain dehydrogenase reductase Sdr
HQR01_10875	COG0604	alcohol dehydrogenase
HQR01_10880	COG0711	Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0)
HQR01_10890	COG0636	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation
HQR01_10895	COG0356	it plays a direct role in the translocation of protons across the membrane
HQR01_10920	COG2003	Belongs to the UPF0758 family
HQR01_10930	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HQR01_10940	COG0284	orotidine-5'-phosphate decarboxylase activity
HQR01_10955	COG0133	tryptophan synthase activity
HQR01_10960	COG0159	tryptophan synthase activity
HQR01_10965	COG0777	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA
HQR01_10970	COG0285	dihydrofolate synthase activity
HQR01_10980	COG4638	Rieske (2fe-2S)
HQR01_10985	COG1187	pseudouridine synthase activity
HQR01_10990	COG0742	ribosomal rna small subunit methyltransferase
HQR01_11020	COG0277	FAD linked oxidase domain protein
HQR01_11050	COG0538	isocitrate dehydrogenase activity
HQR01_11055	COG0475	glutathione-regulated potassium exporter activity
HQR01_11055	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HQR01_11060	COG0013	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain
HQR01_11070	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HQR01_11075	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
HQR01_11085	COG0468	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage
HQR01_11100	COG0691	Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene
HQR01_11110	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HQR01_11115	COG0741	lytic transglycosylase activity
HQR01_11135	COG0820	rRNA (adenine-C2-)-methyltransferase activity
HQR01_11140	COG2258	MOSC domain
HQR01_11150	COG0384	phenazine biosynthesis protein PhzF
HQR01_11155	COG1028	Short-chain dehydrogenase reductase Sdr
HQR01_11165	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
HQR01_11170	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HQR01_11190	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HQR01_11200	COG0583	DNA-binding transcription factor activity
HQR01_11205	COG0137	argininosuccinate synthase activity
HQR01_11210	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HQR01_11255	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HQR01_11280	COG3590	peptidase
HQR01_11285	COG3706	GGDEF domain
HQR01_11290	COG3706	GGDEF domain
HQR01_11300	COG0339	signal peptide processing
HQR01_11305	COG4559	Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system
HQR01_11310	COG4139	cobalamin transport
HQR01_11320	COG4206	TonB-dependent receptor
HQR01_11335	COG5001	Diguanylate cyclase
HQR01_11335	COG3300	MHYT domain
HQR01_11340	COG0039	L-malate dehydrogenase activity
HQR01_11345	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HQR01_11350	COG0567	Dehydrogenase, E1 component
HQR01_11355	COG0508	dehydrogenase complex catalyzes the overall conversion of
HQR01_11360	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HQR01_11370	COG0154	amidase activity
HQR01_11380	COG2860	membrane
HQR01_11395	COG0203	ribosomal protein L17
HQR01_11400	COG0202	RNA polymerase activity
HQR01_11405	COG0100	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome
HQR01_11410	COG0099	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
HQR01_11425	COG0563	adenylate kinase activity
HQR01_11430	COG0201	protein transport
HQR01_11435	COG0200	Binds to the 23S rRNA
HQR01_11445	COG1841	ribosomal large subunit assembly
HQR01_11450	COG0098	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body
HQR01_11455	COG0256	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance
HQR01_11460	COG0097	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center
HQR01_11465	COG0096	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
HQR01_11470	COG0199	Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site
HQR01_11475	COG0094	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
HQR01_11480	COG0198	One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit
HQR01_11485	COG0093	Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome
HQR01_11490	COG0186	One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA
HQR01_11495	COG0255	Belongs to the universal ribosomal protein uL29 family
HQR01_11500	COG0197	Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs
HQR01_11505	COG0092	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation
HQR01_11510	COG0091	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome
HQR01_11515	COG0185	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
HQR01_11520	COG0090	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
HQR01_11525	COG0089	rRNA binding
HQR01_11530	COG0088	Forms part of the polypeptide exit tunnel
HQR01_11535	COG0087	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit
HQR01_11540	COG0051	transcription antitermination factor activity, RNA binding
HQR01_11545	COG0050	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis
HQR01_11550	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HQR01_11555	COG0049	tRNA binding
HQR01_11560	COG0048	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit
HQR01_11600	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
HQR01_11605	COG0248	Ppx GppA phosphatase
HQR01_11610	COG0659	secondary active sulfate transmembrane transporter activity
HQR01_11615	COG2967	ApaG domain
HQR01_11640	COG0840	transmembrane signaling receptor activity
HQR01_11670	COG0473	3-isopropylmalate dehydrogenase activity
HQR01_11675	COG1381	Involved in DNA repair and RecF pathway recombination
HQR01_11690	COG3967	Belongs to the short-chain dehydrogenases reductases (SDR) family
HQR01_11715	COG0513	Belongs to the DEAD box helicase family
HQR01_11730	COG1942	4-Oxalocrotonate Tautomerase
HQR01_11740	COG0166	Belongs to the GPI family
HQR01_11750	COG0571	ribonuclease III activity
HQR01_11755	COG1159	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism
HQR01_11770	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HQR01_11770	COG1754	DNA topoisomerase type I activity
HQR01_11780	COG0758	DNA mediated transformation
HQR01_11785	COG0344	acyl-phosphate glycerol-3-phosphate acyltransferase activity
HQR01_11790	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HQR01_11800	COG0156	8-amino-7-oxononanoate synthase activity
HQR01_11810	COG2175	clavaminate synthase activity
HQR01_11830	COG0625	glutathione transferase activity
HQR01_11900	COG1748	Saccharopine dehydrogenase
HQR01_11920	COG0492	ferredoxin-NADP+ reductase activity
HQR01_11925	COG0544	peptidyl-prolyl cis-trans isomerase activity
HQR01_11945	COG1160	GTP binding
HQR01_11975	COG2311	Membrane
HQR01_12000	COG0044	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides
HQR01_12005	COG0540	Belongs to the ATCase OTCase family
HQR01_12010	COG0616	signal peptide processing
HQR01_12030	COG1309	transcriptional regulator
HQR01_12035	COG4771	TonB-dependent receptor
HQR01_12040	COG0172	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)
HQR01_12050	COG0496	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates
HQR01_12070	COG0621	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine
HQR01_12075	COG2199	diguanylate cyclase activity
HQR01_12075	COG2200	EAL domain
HQR01_12075	COG2202	Pas domain
HQR01_12085	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HQR01_12090	COG0129	dihydroxy-acid dehydratase activity
HQR01_12095	COG0837	glucose binding
HQR01_12100	COG0800	Aldolase
HQR01_12110	COG0037	tRNA processing
HQR01_12145	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HQR01_12165	COG1505	serine-type exopeptidase activity
HQR01_12180	COG1902	pentaerythritol trinitrate reductase activity
HQR01_12190	COG0321	lipoyl(octanoyl) transferase activity
HQR01_12220	COG2080	2 iron, 2 sulfur cluster binding
HQR01_12225	COG0235	Class ii aldolase
HQR01_12230	COG0534	Mate efflux family protein
HQR01_12235	COG0643	Histidine kinase
HQR01_12235	COG0784	Response regulator, receiver
HQR01_12235	COG2198	Histidine kinase
HQR01_12245	COG0745	RESPONSE REGULATOR receiver
HQR01_12250	COG2201	protein-glutamate methylesterase activity
HQR01_12255	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
HQR01_12260	COG5001	Diguanylate cyclase
HQR01_12260	COG3300	MHYT domain
HQR01_12275	COG0402	S-adenosylhomocysteine deaminase activity
HQR01_12300	COG2072	flavoprotein involved in K transport
HQR01_12305	COG1546	Belongs to the CinA family
HQR01_12305	COG1058	Belongs to the CinA family
HQR01_12315	COG0081	regulation of translation
HQR01_12320	COG0080	Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors
HQR01_12325	COG1842	Phage shock protein A
HQR01_12350	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HQR01_12370	COG0823	Involved in the tonB-independent uptake of proteins
HQR01_12370	COG1506	peptidase
HQR01_12370	COG4946	Tricorn protease homolog
HQR01_12405	COG4799	Acetyl-CoA carboxylase, carboxyltransferase component subunits alpha and beta
HQR01_12420	COG0494	nUDIX hydrolase
HQR01_12430	COG0783	Belongs to the Dps family
HQR01_12445	COG1960	acyl-CoA dehydrogenase activity
HQR01_12465	COG3794	PFAM blue (type 1) copper domain protein
HQR01_12495	COG3047	cAMP biosynthetic process
HQR01_12500	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HQR01_12535	COG2217	Heavy metal translocating P-type atpase
HQR01_12550	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HQR01_12585	COG0346	lactoylglutathione lyase activity
HQR01_12590	COG1024	Enoyl-CoA hydratase
HQR01_12600	COG1024	Enoyl-CoA hydratase
HQR01_12625	COG4235	cytochrome complex assembly
HQR01_12630	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HQR01_12645	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HQR01_12680	COG1003	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HQR01_12685	COG0403	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
HQR01_12690	COG0509	glycine decarboxylation via glycine cleavage system
HQR01_12695	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HQR01_12720	COG2226	methyltransferase
HQR01_12780	COG0315	cyclic pyranopterin monophosphate synthase activity
HQR01_12785	COG0521	Mo-molybdopterin cofactor biosynthetic process
HQR01_12800	COG2896	Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate
HQR01_12805	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HQR01_12810	COG2181	nitrate reductase activity
HQR01_12815	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
HQR01_12820	COG1140	nitrate reductase beta subunit
HQR01_12825	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
HQR01_12830	COG2223	nitrite transmembrane transporter activity
HQR01_12845	COG0288	reversible hydration of carbon dioxide
HQR01_12855	COG2201	protein-glutamate methylesterase activity
HQR01_12860	COG1116	anion transmembrane transporter activity
HQR01_12860	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HQR01_12865	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HQR01_12865	COG1116	anion transmembrane transporter activity
HQR01_12875	COG1116	anion transmembrane transporter activity
HQR01_12885	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HQR01_12890	COG2146	nitrite reductase [NAD(P)H] activity
HQR01_12895	COG0243	molybdopterin cofactor binding
HQR01_12900	COG0007	Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD- dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme
HQR01_12900	COG1648	precorrin-2 dehydrogenase activity
HQR01_12915	COG0746	molybdenum cofactor guanylyltransferase activity
HQR01_12925	COG2272	Belongs to the type-B carboxylesterase lipase family
HQR01_12935	COG2272	Belongs to the type-B carboxylesterase lipase family
HQR01_12965	COG2272	Belongs to the type-B carboxylesterase lipase family
HQR01_12970	COG4206	TonB-dependent receptor
HQR01_12975	COG2272	Belongs to the type-B carboxylesterase lipase family
HQR01_12980	COG0183	Belongs to the thiolase family
HQR01_13000	COG2211	Major facilitator Superfamily
HQR01_13005	COG1960	acyl-CoA dehydrogenase activity
HQR01_13015	COG3474	cytochrome
HQR01_13035	COG1309	transcriptional regulator
HQR01_13045	COG0583	DNA-binding transcription factor activity
HQR01_13050	COG1741	Belongs to the pirin family
HQR01_13055	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
HQR01_13065	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
HQR01_13075	COG2986	histidine ammonia-lyase
HQR01_13080	COG1228	amidohydrolase
HQR01_13120	COG1538	Outer membrane efflux protein
HQR01_13125	COG2274	protein secretion by the type I secretion system
HQR01_13150	COG0222	ribosome binding
HQR01_13155	COG0244	Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors
HQR01_13170	COG3655	Transcriptional regulator
HQR01_13190	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HQR01_13195	COG0085	RNA polymerase activity
HQR01_13200	COG0086	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates
HQR01_13205	COG3300	MHYT domain
HQR01_13205	COG5001	Diguanylate cyclase
HQR01_13210	COG1384	Belongs to the class-I aminoacyl-tRNA synthetase family
HQR01_13210	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HQR01_13220	COG0469	pyruvate kinase activity
HQR01_13230	COG3750	Belongs to the UPF0335 family
HQR01_13245	COG0217	transcriptional regulatory protein
HQR01_13255	COG0817	Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group
HQR01_13260	COG1393	Belongs to the ArsC family
HQR01_13265	COG3201	nicotinamide mononucleotide transporter
HQR01_13280	COG0584	glycerophosphoryl diester phosphodiesterase
HQR01_13285	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HQR01_13290	COG0527	aspartate kinase activity
HQR01_13295	COG0027	Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate
HQR01_13335	COG0330	HflC and HflK could
HQR01_13355	COG0582	viral genome integration into host DNA
HQR01_13360	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HQR01_13400	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
HQR01_13410	COG4227	nucleotidyltransferase activity
HQR01_13450	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HQR01_13470	COG0300	oxidoreductase activity
HQR01_13485	COG0517	IMP dehydrogenase activity
HQR01_13485	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HQR01_13490	COG1212	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria
HQR01_13495	COG2877	3-deoxy-8-phosphooctulonate synthase activity
HQR01_13520	COG0438	transferase activity, transferring glycosyl groups
HQR01_13520	COG1216	Glycosyl transferase, family 2
HQR01_13535	COG1596	polysaccharide export
HQR01_13565	COG2801	Transposase and inactivated derivatives
HQR01_13600	COG1482	cell wall glycoprotein biosynthetic process
HQR01_13610	COG0114	fumarate hydratase activity
HQR01_13625	COG0413	3-methyl-2-oxobutanoate hydroxymethyltransferase activity
HQR01_13640	COG0644	oxidoreductase
HQR01_13660	COG0745	RESPONSE REGULATOR receiver
HQR01_13680	COG2207	Transcriptional regulator
HQR01_13690	COG1573	uracil-dna glycosylase
HQR01_13705	COG0667	Aldo Keto reductase
HQR01_13715	COG0431	NADPH-dependent FMN reductase
HQR01_13735	COG1028	Short-chain dehydrogenase reductase Sdr
HQR01_13740	COG0457	Tetratricopeptide repeat
HQR01_13750	COG1309	transcriptional regulator
HQR01_13755	COG4638	Rieske (2fe-2S)
HQR01_13770	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HQR01_13775	COG1228	amidohydrolase
HQR01_13780	COG2301	Belongs to the HpcH HpaI aldolase family
HQR01_13785	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HQR01_13795	COG2030	dehydratase
HQR01_13825	COG1758	RNA polymerase activity
HQR01_13830	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HQR01_13840	COG5328	Belongs to the UPF0262 family
HQR01_13850	COG0295	cytidine deaminase activity
HQR01_13855	COG1619	proteins homologs of microcin C7 resistance protein MccF
HQR01_13875	COG2866	Carboxypeptidase
HQR01_13890	COG0257	Belongs to the bacterial ribosomal protein bL36 family
HQR01_13965	COG0230	Belongs to the bacterial ribosomal protein bL34 family
HQR01_13970	COG0594	ribonuclease P activity
HQR01_13975	COG0759	Could be involved in insertion of integral membrane proteins into the membrane
HQR01_13980	COG0706	membrane insertase activity
HQR01_13985	COG0218	Necessary for normal cell division and for the maintenance of normal septation
HQR01_14010	COG0625	glutathione transferase activity
HQR01_14020	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HQR01_14025	COG1301	dicarboxylic acid transport
HQR01_14030	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HQR01_14035	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HQR01_14040	COG0289	4-hydroxy-tetrahydrodipicolinate reductase
HQR01_14045	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HQR01_14050	COG4771	TonB-dependent receptor
HQR01_14055	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HQR01_14065	COG0593	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids
HQR01_14070	COG0268	Binds directly to 16S ribosomal RNA
HQR01_14075	COG0229	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HQR01_14080	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HQR01_14100	COG0489	protein tyrosine kinase activity
HQR01_14105	COG2010	Cytochrome c
HQR01_14105	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HQR01_14110	COG0276	Catalyzes the ferrous insertion into protoporphyrin IX
HQR01_14125	COG0781	Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons
HQR01_14125	COG0144	Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA
HQR01_14140	COG0225	Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine
HQR01_14150	COG0171	NAD+ synthase (glutamine-hydrolyzing) activity
HQR01_14150	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HQR01_14155	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HQR01_14160	COG0110	maltose O-acetyltransferase activity
HQR01_14195	COG4566	intracellular signal transduction
HQR01_14220	COG0175	sulfate reduction
HQR01_14230	COG1960	acyl-CoA dehydrogenase activity
HQR01_14235	COG1960	acyl-CoA dehydrogenase activity
HQR01_14250	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
HQR01_14280	COG1082	Xylose isomerase domain protein TIM barrel
HQR01_14285	COG0366	Alpha amylase catalytic
HQR01_14315	COG1940	carbohydrate kinase activity
HQR01_14325	COG0183	Belongs to the thiolase family
HQR01_14330	COG1024	Enoyl-CoA hydratase
HQR01_14360	COG0438	transferase activity, transferring glycosyl groups
HQR01_14375	COG1960	acyl-CoA dehydrogenase activity
HQR01_14400	COG2304	oxidoreductase activity
HQR01_14410	COG0240	glycerol-3-phosphate dehydrogenase [NAD(P)+] activity
HQR01_14415	COG0533	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction
HQR01_14420	COG0181	hydroxymethylbilane synthase activity
HQR01_14445	COG1024	Enoyl-CoA hydratase
HQR01_14445	COG1250	3-hydroxyacyl-CoA dehydrogenase
HQR01_14475	COG1960	acyl-CoA dehydrogenase activity
HQR01_14480	COG1218	3'(2'),5'-bisphosphate nucleotidase
HQR01_14490	COG1472	Belongs to the glycosyl hydrolase 3 family
HQR01_14500	COG1609	Transcriptional regulator
HQR01_14535	COG1960	acyl-CoA dehydrogenase activity
HQR01_14540	COG1028	Short-chain dehydrogenase reductase Sdr
HQR01_14545	COG0667	Aldo Keto reductase
HQR01_14550	COG0745	RESPONSE REGULATOR receiver
HQR01_14575	COG0480	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome
HQR01_14595	COG1196	nuclear chromosome segregation
HQR01_14595	COG0741	lytic transglycosylase activity
HQR01_14595	COG0739	heme binding
HQR01_14610	COG3451	type IV secretory pathway VirB4
HQR01_14630	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis
HQR01_14655	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
HQR01_14660	COG0271	Belongs to the BolA IbaG family
HQR01_14680	COG0066	3-isopropylmalate dehydratase activity
HQR01_14695	COG0065	Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate
HQR01_14700	COG0824	Thioesterase
HQR01_14715	COG2166	iron-sulfur cluster assembly
HQR01_14760	COG1842	Phage shock protein A
HQR01_14770	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
HQR01_14775	COG0779	Required for maturation of 30S ribosomal subunits
HQR01_14790	COG0532	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
HQR01_14800	COG0858	One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA
HQR01_14805	COG1024	Enoyl-CoA hydratase
HQR01_14820	COG1435	thymidine kinase activity
HQR01_14830	COG1994	Peptidase M50
HQR01_14835	COG0130	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs
HQR01_14840	COG0184	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome
HQR01_14845	COG1185	polyribonucleotide nucleotidyltransferase activity
HQR01_14865	COG0842	Transport permease protein
HQR01_14880	COG0326	Molecular chaperone. Has ATPase activity
HQR01_14925	COG0789	Transcriptional regulator
HQR01_14930	COG2217	Heavy metal translocating P-type atpase
HQR01_14960	COG0142	geranyltranstransferase activity
HQR01_15015	COG0583	DNA-binding transcription factor activity
HQR01_15025	COG1028	Short-chain dehydrogenase reductase Sdr
HQR01_15035	COG1252	NADH dehydrogenase
HQR01_15040	COG0604	alcohol dehydrogenase
HQR01_15040	COG3321	synthase
HQR01_15095	COG1236	Exonuclease of the beta-lactamase fold involved in RNA processing
HQR01_15100	COG0213	The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis
HQR01_15120	COG4772	TonB-dependent receptor
HQR01_15130	COG1609	Transcriptional regulator