locus-tag class description VEGS01_00020 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) VEGS01_00040 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) VEGS01_00050 ENOG4105VP5 Bacterial protein of unknown function (DUF937) VEGS01_00060 ENOG410667J hydrolase VEGS01_00070 ENOG410657R replicase EC 2.7 VEGS01_00080 ENOG4105EMF GntR family transcriptional regulator VEGS01_00090 ENOG4105EI3 2-dehydro-3-deoxygalactonokinase EC 2.7.1.58 VEGS01_00100 ENOG4108RTU Aldolase VEGS01_00120 ENOG4105DJB Major Facilitator Superfamily VEGS01_00140 ENOG4105D99 atp gtp-binding protein VEGS01_00150 ENOG4105R2A (LipO)protein VEGS01_00190 ENOG4105FDP GntR family transcriptional regulator VEGS01_00200 ENOG4105CI1 PTS System VEGS01_00220 ENOG4105F8D glycoside hydrolase family 4 VEGS01_00230 ENOG4108AHD Transcriptional regulator VEGS01_00240 ENOG4107RUZ Sss sodium solute transporter superfamily VEGS01_00250 ENOG4105CBG Sulfatase VEGS01_00260 ENOG4106DRA Inner membrane protein YidI VEGS01_00270 ENOG4105VG5 Membrane VEGS01_00280 ENOG4105JP4 Inner membrane protein yidG VEGS01_00290 ENOG4105J13 transcriptional regulator VEGS01_00300 ENOG4105E5M Multidrug resistance protein D VEGS01_00310 ENOG4105C7K acetolactate synthase VEGS01_00320 ENOG4105M71 acetolactate synthase 1 regulatory subunit VEGS01_00330 ENOG4108KX4 response regulator VEGS01_00340 ENOG4105BZU Histidine kinase VEGS01_00350 ENOG4105CXY transporter VEGS01_00360 ENOG4105CXY transporter VEGS01_00370 ENOG4105CPN adenine deaminase VEGS01_00380 ENOG4105C7N Xanthine uracil vitamin C permease VEGS01_00390 ENOG4108SAJ Protein of unknown function (DUF1198) VEGS01_00410 ENOG4105T8A Uncharacterized protein YicS VEGS01_00420 ENOG4105D01 (LipO)protein VEGS01_00430 ENOG4108UZ3 Transporter VEGS01_00440 ENOG4105S8Q sugar efflux transporter VEGS01_00480 ENOG4105DFP Integrase VEGS01_00490 ENOG4105CT4 transporter VEGS01_00500 ENOG4105CJQ hydrolase, family 31 VEGS01_00510 ENOG4105JV1 AsmA family VEGS01_00520 ENOG4105C2W permease VEGS01_00530 ENOG4105D6U Sodium Glutamate Symporter VEGS01_00540 ENOG4105CB5 ATP-dependent DNA helicase recG VEGS01_00550 ENOG4105FE8 tRNA (Guanosine-2'-O-)-methyltransferase VEGS01_00560 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) VEGS01_00580 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) VEGS01_00590 ENOG410649J Catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction (By similarity) VEGS01_00600 ENOG4105EN6 Membrane VEGS01_00610 ENOG4105F5P DNA-damage-inducible protein d VEGS01_00620 ENOG4105F5P DNA-damage-inducible protein d VEGS01_00630 ENOG4105DSJ YicC domain protein VEGS01_00670 ENOG4108Z1K This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) VEGS01_00680 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase VEGS01_00700 ENOG4105KDC 50s ribosomal protein l28 VEGS01_00740 ENOG4105D8A 3-Deoxy-D-manno-octulosonic-acid transferase VEGS01_00750 ENOG4105DKP glycosyl transferase, family 9 VEGS01_00760 ENOG4107RJ7 Glycosyl transferase (Group 1 VEGS01_00770 ENOG4107543 (lipo)polysaccharide VEGS01_00780 ENOG4106AH0 Glycosyl Transferase VEGS01_00790 ENOG4108PDR lipopolysaccharide core biosynthesis protein VEGS01_00800 ENOG4105X1N Glycosyl transferase family 8 VEGS01_00810 ENOG4107XB0 Lipopolysaccharide 1,2-N-acetylglucosaminetransferase VEGS01_00820 ENOG4108FRV O-antigen ligase VEGS01_00830 ENOG4105D16 lipopolysaccharide heptosyltransferase i VEGS01_00840 ENOG4105XA0 heptosyltransferase ii VEGS01_00860 ENOG4108SEH involved in lipopolysaccharide biosynthesis VEGS01_00870 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) VEGS01_00880 ENOG4105CPQ Dehydrogenase VEGS01_00890 ENOG4105K64 Glycosyl transferase, family 2 VEGS01_00900 ENOG4105PXI polysaccharide deacetylase VEGS01_00910 ENOG41063SB peptidase VEGS01_00920 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) VEGS01_00930 ENOG4107YZP Rhodanese domain protein VEGS01_00940 ENOG4105VW4 glutaredoxin 3 VEGS01_00970 ENOG4105D7W serine acetyltransferase VEGS01_00980 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) VEGS01_01000 ENOG41073TP transcriptional regulator VEGS01_01010 ENOG4105DAA L-lactate VEGS01_01020 ENOG4108YYI Protein of unknown function (DUF2810) VEGS01_01040 ENOG4105E61 Mannitol repressor protein VEGS01_01060 ENOG4105CTS PTS system mannitol-specific VEGS01_01070 ENOG4105FP6 Protein of unknown function (DUF3302) VEGS01_01080 ENOG4105EFX secretion protein, HlyD family VEGS01_01130 ENOG4105NUP lyase containing HEAT-repeat VEGS01_01140 ENOG4105CNA YD repeat protein VEGS01_01150 ENOG4108U78 Glutathione S-transferase VEGS01_01170 ENOG4105EM7 Selenocysteine-specific translation elongation factor VEGS01_01180 ENOG4105C0A alcohol dehydrogenase VEGS01_01190 ENOG4105C26 Dehydrogenase VEGS01_01210 ENOG4105KK7 inner membrane protein YiaW VEGS01_01220 ENOG4105EFX secretion protein, HlyD family VEGS01_01230 ENOG4108Q2M Transcriptional regulator VEGS01_01240 ENOG4105GNX MltA-interacting MipA family protein VEGS01_01250 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase VEGS01_01260 ENOG41064BZ L-xylulose 5-phosphate 3-epimerase VEGS01_01270 ENOG4105H6Q decarboxylase VEGS01_01280 ENOG4105CMG Carbohydrate kinase VEGS01_01290 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit VEGS01_01300 ENOG4105CG6 trap dicarboxylate transporter dctm subunit VEGS01_01310 ENOG4105XDZ Tripartite ATP-independent periplasmic transporter VEGS01_01320 ENOG4108R66 Conserved Protein VEGS01_01340 ENOG4105J4Q Transcriptional regulator VEGS01_01350 ENOG4108XIB electron transport protein ysaA VEGS01_01360 ENOG4105JKW Valine--pyruvate aminotransferase VEGS01_01370 ENOG4107T9C Alpha amylase catalytic region VEGS01_01380 ENOG4108UR8 BAX protein VEGS01_01390 ENOG4105T16 Transcriptional regulator (AraC family) VEGS01_01400 ENOG4108HWW ABC transporter VEGS01_01410 ENOG4105C2J ABC transporter VEGS01_01420 ENOG4105DFW ABC transporter VEGS01_01430 ENOG4105C93 Xylose Isomerase VEGS01_01440 ENOG4105CMG Carbohydrate kinase VEGS01_01450 ENOG410688U Inner membrane protein yiaB VEGS01_01460 ENOG4108Z12 YiaAB two helix domain-containing protein VEGS01_01470 ENOG4105MEV Acyl-transferase VEGS01_01480 ENOG4105RGS lipoprotein ysaB VEGS01_01510 ENOG4105DQ6 Transposase VEGS01_01520 ENOG410698F IS150 protein InsA VEGS01_01540 ENOG4105MVF Transcriptional regulator VEGS01_01550 ENOG4106JH6 (LipO)protein VEGS01_01560 ENOG4105C5I Dehydrogenase VEGS01_01570 ENOG4108ZG0 Ompa motb domain protein VEGS01_01580 ENOG4107QY8 reductase VEGS01_01590 ENOG4105HNP -acetyltransferase VEGS01_01600 ENOG4108R3E Dna-3-methyladenine glycosylase i VEGS01_01610 ENOG4105EAX Putative lipase VEGS01_01620 ENOG4105FCD Major Facilitator VEGS01_01630 ENOG4105DIJ Phosphoethanolamine transferase VEGS01_01640 ENOG4105DEF Extracellular solute-binding protein, family 5 VEGS01_01650 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component VEGS01_01660 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component VEGS01_01670 ENOG4105C3U ABC transporter VEGS01_01680 ENOG4108JQ7 (ABC) transporter VEGS01_01690 ENOG4105C44 Serine transporter VEGS01_01710 ENOG4105D1V cellulose synthase operon protein YhjU VEGS01_01720 ENOG4105WQA Cellulose biosynthesis protein BcsF VEGS01_01730 ENOG4105U74 cellulose biosynthesis protein BcsE VEGS01_01740 ENOG410600T transposase VEGS01_01760 ENOG4107QZ7 Cellulose synthase catalytic subunit VEGS01_01770 ENOG4107EEX Cellulose synthase regulator protein VEGS01_01780 ENOG4105K2Z endo-1,4-d-glucanase (EC 3.2.1.4) VEGS01_01790 ENOG4105EJG cellulose synthase VEGS01_01800 ENOG4105BZU Histidine kinase VEGS01_01820 ENOG4105CS0 peptidase VEGS01_01830 ENOG4107SS6 2-dehydro-3-deoxygluconokinase VEGS01_01840 ENOG4105CMB EAL domain-containing protein VEGS01_01850 ENOG41066T0 asmA family VEGS01_01860 ENOG4105CSH Transporter VEGS01_01870 ENOG4107H3J ribonuclease VEGS01_01880 ENOG4105CBN LysR family transcriptional regulator VEGS01_01890 ENOG4106S2D Transcriptional regulator VEGS01_01910 ENOG4105CA0 peroxidase VEGS01_01920 ENOG4105CVK Glutamate decarboxylase VEGS01_01940 ENOG4105BZS acriflavin resistance protein VEGS01_01950 ENOG4105C1P efflux transporter, rnd family, mfp subunit VEGS01_01960 ENOG4106WJ0 Regulates the expression of several genes involved in acid resistance. Required for the expression of gadA and gadBC, among others, regardless of media or growth conditions. Binds directly to the 20 bp GAD box found in the control regions of both loci VEGS01_01970 ENOG4108YK4 Acid-resistance membrane protein VEGS01_01980 ENOG41060V2 Acid-resistance protein VEGS01_01990 ENOG4105XXV Acid-resistance protein VEGS01_02000 ENOG4105KT7 mgtC SapB transporter VEGS01_02020 ENOG4105Y4Z Outer Membrane Lipoprotein VEGS01_02060 ENOG4105K89 arsenate reductase VEGS01_02070 ENOG4107R5R arsenical pump membrane protein VEGS01_02080 ENOG4105KBH arsR family transcriptional regulator VEGS01_02110 ENOG4105DC8 reductase VEGS01_02120 ENOG4105D6S protein involved in catabolism of external DNA VEGS01_02130 ENOG4105DGW oligopeptidase A VEGS01_02150 ENOG4105DUX Transporter VEGS01_02190 ENOG4105CJ3 phosphate transporter VEGS01_02200 ENOG4105CBX hi0933 family VEGS01_02210 ENOG4107UNS conserved inner membrane protein VEGS01_02250 ENOG4105D0S secretion protein (HlyD VEGS01_02260 ENOG4105CJ1 ABC, transporter VEGS01_02270 ENOG4105CMI transporter VEGS01_02280 ENOG410600T transposase VEGS01_02300 ENOG4105CNA YD repeat protein VEGS01_02320 ENOG4105EFJ Part of the ABC transporter complex NikABCDE involved in nickel import. Responsible for energy coupling to the transport system (By similarity) VEGS01_02330 ENOG4106665 Part of the ABC transporter complex NikABCDE involved in nickel import. Responsible for energy coupling to the transport system (By similarity) VEGS01_02340 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component VEGS01_02350 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component VEGS01_02360 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein VEGS01_02370 ENOG4107YAK holo-(acyl carrier protein) synthase 2 VEGS01_02380 ENOG4105DSF transport protein VEGS01_02390 ENOG4105F9N Major Facilitator Superfamily VEGS01_02400 ENOG4108W1V Lipoprotein VEGS01_02410 ENOG4105EX9 Membrane VEGS01_02440 ENOG4107FS9 Membrane VEGS01_02460 ENOG4105MG3 Membrane VEGS01_02470 ENOG4106H78 methyltransferase VEGS01_02480 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) VEGS01_02490 ENOG4105CAK Cell division ATP-binding protein ftsE VEGS01_02500 ENOG4105CRP Part of the ABC transporter FtsEX involved in VEGS01_02510 ENOG4105DEK Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) VEGS01_02520 ENOG4105CP9 extracellular ligand-binding receptor VEGS01_02530 ENOG4105U59 -acetyltransferase VEGS01_02540 ENOG4105CP9 extracellular ligand-binding receptor VEGS01_02550 ENOG4105C32 Amino acid ABC transporter (Permease) VEGS01_02560 ENOG4105CF8 branched-chain amino acid ABC transporter, permease VEGS01_02570 ENOG4105C0Z ABC transporter VEGS01_02580 ENOG4108IV0 ABC, transporter VEGS01_02590 ENOG4105BZ7 extracellular solute-binding protein family 1 VEGS01_02600 ENOG4105E4X binding-protein-dependent transport systems inner membrane Component VEGS01_02610 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component VEGS01_02630 ENOG4107T6V glycerophosphoryl diester phosphodiesterase VEGS01_02640 ENOG4105WC8 Conserved Protein VEGS01_02650 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) VEGS01_02660 ENOG4106FA4 VEGS01_02690 ENOG4105GMB type VI secretion system effector, hcp1 family VEGS01_02700 ENOG4105WCN acetyltransferase VEGS01_02730 ENOG4105D9R oxidoreductase VEGS01_02740 ENOG4105C2I pirin domain protein VEGS01_02750 ENOG4105DIQ Transcriptional regulator VEGS01_02760 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family VEGS01_02770 ENOG4105C6Z Gluconate VEGS01_02780 ENOG41076UM multiple antibiotic resistance (MarC)-related protein VEGS01_02790 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) VEGS01_02810 ENOG4108IUM Glycogen debranching enzyme VEGS01_02840 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) VEGS01_02860 ENOG4105C6V Glycerol-3-phosphate dehydrogenase VEGS01_02890 ENOG4105E98 transcriptional regulator DeoR family VEGS01_02900 ENOG4105CYB regulatoR VEGS01_02910 ENOG4105E0Y RtcB Protein VEGS01_02920 ENOG4105CKX Catalyzes the conversion of 3'-phosphate to a 2',3'- cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps (A) adenylation of the enzyme by ATP VEGS01_02940 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) VEGS01_02950 ENOG4107RTM 4-alpha-glucanotransferase (EC 2.4.1.25) VEGS01_02960 ENOG4105C6Z Gluconate VEGS01_02990 ENOG4105DNE Transposase VEGS01_03010 ENOG4105CE1 Ferrous iron transport protein b VEGS01_03020 ENOG4105XFK Ferrous iron transport protein A VEGS01_03030 ENOG4105BZM domain protein VEGS01_03040 ENOG4108RRZ Transcription elongation factor GreB VEGS01_03060 ENOG4105E0F Histidine kinase VEGS01_03080 ENOG4108MAJ Membrane VEGS01_03100 ENOG4105VEJ Heat shock protein VEGS01_03110 ENOG4107Y3D HAD-superfamily hydrolase subfamily IA variant 3 VEGS01_03120 ENOG4105DQY intracellular growth attenuator VEGS01_03130 ENOG4107RK2 ADP-ribose diphosphatase NudE VEGS01_03140 ENOG4108JQC penicillin-binding protein 1A VEGS01_03150 ENOG4108U1Q Pilus assembly protein VEGS01_03160 ENOG41065NF Fimbrial assembly family protein VEGS01_03170 ENOG4105XPX DNA utilization protein HofO VEGS01_03180 ENOG4105ITY Required for the use of extracellular DNA as a nutrient VEGS01_03190 ENOG4105E4G Type IV pilus VEGS01_03220 ENOG4105EGB membrane protein DamX VEGS01_03230 ENOG4105DFE Dna adenine methylase VEGS01_03240 ENOG4105DJV ribulose-phosphate 3-epimerase VEGS01_03250 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) VEGS01_03260 ENOG4105C31 Tryptophanyl-tRNA synthetase VEGS01_03270 ENOG4108M21 VEGS01_03280 ENOG4105RMW regulation of transcription, DNA-dependent VEGS01_03290 ENOG4108626 Racemase VEGS01_03300 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) VEGS01_03310 ENOG41080QX K07048 phosphotriesterase-related protein VEGS01_03320 ENOG4105MUZ Protein of unknown function DUF2620 VEGS01_03330 ENOG4106M0N transport system permease protein VEGS01_03340 ENOG4106PKC pyridoxal phosphate binding VEGS01_03350 ENOG4105FDP GntR family transcriptional regulator VEGS01_03360 ENOG4108KPW sugar kinase VEGS01_03370 ENOG4107Y0V Not clear, may be involved in an isomerization step VEGS01_03380 ENOG4107R1S catalyzes the conversion of fructoselysine 6-phosphate to glucose 6-phosphate and lysine VEGS01_03390 ENOG4107QHQ amino acid VEGS01_03400 ENOG4105VYH VEGS01_03420 ENOG4107V9H nitrite transporter VEGS01_03430 ENOG4105WZK nitrite reductase NADPH small subunit VEGS01_03440 ENOG4107QZF nitrite reductase NADPH large subunit VEGS01_03460 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) VEGS01_03480 ENOG4105MZU cell filamentation protein VEGS01_03490 ENOG4105DDQ anthranilate synthase VEGS01_03500 ENOG4105C8Y Acetylornithine aminotransferase VEGS01_03510 ENOG410613R integral membrane protein, YccS YhfK family VEGS01_03530 ENOG4108UKZ OsmC family VEGS01_03540 ENOG4105CJE phosphoribulokinase (EC 2.7.1.19) VEGS01_03560 ENOG4105DNZ Alpha Beta Hydrolase VEGS01_03570 ENOG4105C5H ABC transporter VEGS01_03590 ENOG4105CKD glutathione-regulated potassium-efflux system protein VEGS01_03600 ENOG4105VKU nucleicacid-binding protein VEGS01_03610 ENOG4108YZY peptidylprolyl cis-trans isomerase VEGS01_03630 ENOG4108V1T peptidylprolyl cis-trans isomerase VEGS01_03640 ENOG4105WWK YheO domain protein VEGS01_03650 ENOG4108ZAT Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE (By similarity) VEGS01_03660 ENOG4108ZKU Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions (By similarity) VEGS01_03670 ENOG4105YKK Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions (By similarity) VEGS01_03720 ENOG4108NNZ chitinase VEGS01_03730 ENOG4105W53 bacterioferritin-associated ferredoxin VEGS01_03740 ENOG4108UQY Iron-storage protein VEGS01_03750 ENOG4105EHH Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue (By similarity) VEGS01_03770 ENOG41063JA Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins (By similarity) VEGS01_03780 ENOG4105R04 type II secretion system protein K VEGS01_03810 ENOG41069X0 general secretion pathway protein h VEGS01_03820 ENOG4108VAU general secretion pathway protein G VEGS01_03830 ENOG4105D7Q type ii secretion system VEGS01_03840 ENOG4107QHF type ii secretion system protein e VEGS01_03850 ENOG4105GVR general secretion pathway protein D VEGS01_03860 ENOG4107KSE General secretion pathway protein C VEGS01_03870 ENOG410899B May play a regulatory role under conditions of derepressed gsp gene expression VEGS01_03880 ENOG4107ACA Calcium-binding protein required for initiation of chromosome replication VEGS01_03920 ENOG41080KG One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) VEGS01_04010 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) VEGS01_04100 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) VEGS01_04160 ENOG4105VTS DnaJ-like, subfamily C VEGS01_04170 ENOG4105W1Y Transcriptional regulator VEGS01_04180 ENOG4105VCN Rescues the ribosomes stalled at the 3' end of non-stop mRNAs. May induce hydrolysis of the ribosome-bound peptidyl-tRNA. This activity is crucial when the stalled ribosome can not be rescued by the SsrA(tmRNA)-SmpB quality control system VEGS01_04200 ENOG4105C1A potassium transporter peripheral membrane VEGS01_04240 ENOG4105C79 DNA protecting protein DprA VEGS01_04290 ENOG4105SG3 Protein of unknown function (DUF1488) VEGS01_04300 ENOG4108Z0R Transferase VEGS01_04310 ENOG4105CDA abc transporter atp-binding protein VEGS01_04320 ENOG4105DRP amino acid AbC transporter VEGS01_04330 ENOG4105EZ7 amino acid ABC transporter VEGS01_04350 ENOG4105XCM membrane LIPOPROTEIN VEGS01_04360 ENOG4105BZS acriflavin resistance protein VEGS01_04370 ENOG4105C1P efflux transporter, rnd family, mfp subunit VEGS01_04380 ENOG4108XG4 DNA-binding transcriptional regulator VEGS01_04390 ENOG4105CEC DNA methylase N-4 N-6 VEGS01_04410 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) VEGS01_04430 ENOG4108IA2 Sodium pantothenate symporter VEGS01_04440 ENOG4105RG0 Membrane VEGS01_04450 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase VEGS01_04460 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein VEGS01_04480 ENOG4105D3Z quinone oxidoreductase, yhdh yhfp family VEGS01_04490 ENOG41062P1 Diguanylate cyclase phosphodiesterase VEGS01_04510 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) VEGS01_04520 ENOG4105VQ7 Rod shape-determining protein MreD VEGS01_04540 ENOG4105C03 ribonuclease VEGS01_04550 ENOG4105QD6 exported protein VEGS01_04560 ENOG4105D1U peptidase U62 modulator of DNA gyrase VEGS01_04570 ENOG4105CR8 Transcriptional regulator VEGS01_04580 ENOG4105ZQC membrane protein AaeX VEGS01_04610 ENOG4105UNR (Barnase) inhibitor VEGS01_04620 ENOG4105RID UPF0379 protein yhcN VEGS01_04650 ENOG4105C0H protease VEGS01_04660 ENOG4105C0H protease VEGS01_04670 ENOG4108W2Q Cytochrome d ubiquinol oxidase subunit III VEGS01_04680 ENOG4105D6Z AFG1 family ATPase VEGS01_04710 ENOG4107MKT Stringent starvation protein a VEGS01_04720 ENOG4105KB2 stringent starvation protein b VEGS01_04730 ENOG4105CEE C4-dicarboxylate transporter VEGS01_04740 ENOG4108QBF Transcriptional regulator VEGS01_04760 ENOG4105JHE Major Facilitator Superfamily VEGS01_04780 ENOG41061DF Catalyzes the phosphorylation of N-acetylmannosamine (ManNAc) to ManNAc-6-P (By similarity) VEGS01_04790 ENOG4108R66 Conserved Protein VEGS01_04800 ENOG4105DFS Conserved Protein VEGS01_04810 ENOG4105UMR response to DNA damage stimulus VEGS01_04830 ENOG4105E6S usher protein( VEGS01_04840 ENOG4108S1B Periplasmic chaperone protein VEGS01_04850 ENOG4106AJS Involved in induction of the so-called NTR enzymes in response to nitrogen deprivation, as well as in glutamate biosynthesis. May mediate the glutamate-dependent repression of the GLT operon VEGS01_04860 ENOG4105BZ8 glutamate synthase VEGS01_04870 ENOG4105CBC glutamate synthase VEGS01_04880 ENOG4105N5T Radical SAM Protein VEGS01_04890 ENOG4105BZU Histidine kinase VEGS01_04900 ENOG4108556 Isoprenoid biosynthesis protein with amidotransferase-like domain VEGS01_04920 ENOG4108NIH transferase activity, transferring phosphorus-containing groups VEGS01_04930 ENOG41080Z8 PHOSPHOCARRIER protein VEGS01_04950 ENOG4107RM2 PTS IIA-like nitrogen-regulatory protein PtsN VEGS01_04960 ENOG41080QH sigma 54 modulation protein ribosomal protein S30EA VEGS01_04970 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) VEGS01_04980 ENOG4108IUZ ABC transporter VEGS01_04990 ENOG4105WI0 lipopolysaccharide transport periplasmic protein lptA VEGS01_05000 ENOG4108P1K Required for the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane (By similarity) VEGS01_05010 ENOG4108Z4R 3-deoxy-d-manno-octulosonate 8-phosphate phosphatase VEGS01_05020 ENOG4105C2X Arabinose 5-phosphate isomerase VEGS01_05030 ENOG4105FEU K -dependent Na -Ca exchanger VEGS01_05040 ENOG4105DHJ ABC, transporter VEGS01_05050 ENOG4105CY3 ABC transporter, permease VEGS01_05060 ENOG4107PE3 Mammalian cell entry related domain protein VEGS01_05070 ENOG4105E3I toluene tolerance VEGS01_05080 ENOG4105UE2 Part of the ABC transporter complex MlaFEDB that actively prevents phospholipid accumulation at the cell surface. Probably maintains lipid asymmetry in the outer membrane by retrograde trafficking of phospholipids from the outer membrane to the inner membrane VEGS01_05090 ENOG4105VFK BolA family VEGS01_05110 ENOG4105HVQ Regulatory factor of maltose metabolism VEGS01_05120 ENOG4105EAH synthase VEGS01_05150 ENOG4105QYV Membrane VEGS01_05170 ENOG4106HRJ d-alanyl-d-alanine carboxypeptidase VEGS01_05180 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) VEGS01_05190 ENOG4105HBR Rna-binding protein VEGS01_05210 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) VEGS01_05220 ENOG4105EEI dihydropteroate synthase VEGS01_05240 ENOG4105NTZ Preprotein translocase subunit SecG VEGS01_05250 ENOG4105DIJ Phosphoethanolamine transferase VEGS01_05280 ENOG4105CHV Transcription elongation factor NusA VEGS01_05350 ENOG4105C1J atp-dependent rna helicase VEGS01_05360 ENOG4105CIC tryptophan-specific transport protein VEGS01_05370 ENOG4105DEN Luciferase family VEGS01_05410 ENOG4108YYD acetyltransferase VEGS01_05420 ENOG41082IR Excinuclease ABC C subunit domain protein VEGS01_05440 ENOG4107R7Y intracellular protease Pfpi family VEGS01_05450 ENOG4105K4T epimerase VEGS01_05460 ENOG4107S21 permease VEGS01_05470 ENOG4105W4M Transport-associated protein VEGS01_05490 ENOG41082RQ UPF0102 protein VEGS01_05500 ENOG4105E1C Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1A (PBP1a) (By similarity) VEGS01_05510 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) VEGS01_05520 ENOG4105I74 Fimbrial protein VEGS01_05530 ENOG4105CW0 outer membrane usher protein VEGS01_05540 ENOG4108MBK is1 orf2 VEGS01_05560 ENOG4106HBN Galactosamine-6-phosphate isomerase VEGS01_05570 ENOG4105F3R pts system mannose fructose sorbose family iid VEGS01_05580 ENOG4105ETZ PTS System VEGS01_05590 ENOG4108UZY PTS System VEGS01_05610 ENOG4105E70 isomerase VEGS01_05620 ENOG4105CE4 GlcNAc 6-P deacetylase VEGS01_05630 ENOG4105CE4 GlcNAc 6-P deacetylase VEGS01_05640 ENOG4108YTN IIa component VEGS01_05650 ENOG4105F3R pts system mannose fructose sorbose family iid VEGS01_05660 ENOG4105F3R pts system mannose fructose sorbose family iid VEGS01_05680 ENOG4108RG5 PTS system N-acetylgalactosamine-specific transporter subunit IIB VEGS01_05700 ENOG4105E98 transcriptional regulator DeoR family VEGS01_05710 ENOG4108R8Z these effects are overcome by concomitant expression of antitoxin SohA (PrlF). Massive overexpression is toxic. Unlike most other characterized TA systems degrades rRNA, and co-folding of the proteins is necessary in vitro for inhibition of the RNase activity. It is not known if it has any sequence-specificity. Acts as a transcription factor. The YhaV PrlF complex binds the prlF-yhaV operon, probably negatively regulating its expression VEGS01_05720 ENOG4105ZEG Suppressor protein VEGS01_05730 ENOG4105CTX dehydratase VEGS01_05740 ENOG4105DJB Major Facilitator Superfamily VEGS01_05760 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase VEGS01_05770 ENOG4105BZW Glycerate kinase VEGS01_05800 ENOG410811B TRANSCRIPTIONal VEGS01_05810 ENOG4105C7B Threonine dehydratase VEGS01_05830 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) VEGS01_05840 ENOG4105C6N Formate acetyltransferase VEGS01_05850 ENOG4105KME endoribonuclease L-psp VEGS01_05860 ENOG4105EJQ L-serine dehydratase VEGS01_05870 ENOG4105C44 Serine transporter VEGS01_05880 ENOG4105CEM UPF0597 protein VEGS01_05890 ENOG4106D80 Uncharacterized protein YhaL VEGS01_05900 ENOG4108CNN domain protein VEGS01_05910 ENOG4105CWB LysR family transcriptional Regulator VEGS01_05920 ENOG4105KAF membrAne VEGS01_05930 ENOG4105KAF membrAne VEGS01_05940 ENOG4105CHF Glutathione S-transferase VEGS01_05950 ENOG4108VBZ doxx family VEGS01_05960 ENOG4105YJD VEGS01_05970 ENOG41090KG Inner membrane protein YqjE VEGS01_05980 ENOG4105NE1 Conserved Protein VEGS01_05990 ENOG4105WAY exported protein VEGS01_06000 ENOG4105IYR Modulates the activity of the EnvZ OmpR two-component regulatory system, probably by directly modulating EnvZ enzymatic activity and increasing stability of phosphorylated OmpR (By similarity) VEGS01_06010 ENOG4106W5V Membrane VEGS01_06020 ENOG4107YCY Transcriptional regulator VEGS01_06030 ENOG4105DPW Major facilitator superfamily MFS_1 VEGS01_06050 ENOG4105CTX dehydratase VEGS01_06060 ENOG4105P66 Membrane VEGS01_06070 ENOG4107QV7 Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system) (By similarity) VEGS01_06080 ENOG4105DU1 integral membrane protein, terc VEGS01_06090 ENOG4105EE0 oxidoreductase VEGS01_06100 ENOG4108UB4 uncharacterized protein ygjQ VEGS01_06110 ENOG4108VKG metal-dependent hydrolase VEGS01_06120 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) VEGS01_06130 ENOG4105R48 this blockage is overcome by subsequent expression of antitoxin HigA. Overexpression causes cleavage of a number of mRNAs in a translation-dependent fashion, suggesting this is an mRNA interferase VEGS01_06140 ENOG4108Z3N Transcriptional regulator VEGS01_06150 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase VEGS01_06160 ENOG4107WCA isomerase VEGS01_06170 ENOG4105F9F transposase VEGS01_06200 ENOG4105F9F transposase VEGS01_06210 ENOG4107WCA isomerase VEGS01_06220 ENOG4107W6W Conserved Protein VEGS01_06230 ENOG4105E5D amino acid VEGS01_06240 ENOG4105FK9 beta-D-galactosidase beta subunit VEGS01_06250 ENOG4105CNT hydrolase family 2 VEGS01_06260 ENOG4105CQ4 Transcriptional regulator VEGS01_06270 ENOG4108Y51 tRNA-binding protein VEGS01_06280 ENOG4105C8Y Acetylornithine aminotransferase VEGS01_06290 ENOG4107RHT methyl-accepting chemotaxis sensory transducer with Pas Pac sensor VEGS01_06300 ENOG4105NTW Transcriptional regulator VEGS01_06310 ENOG4105Q26 Siderophore-interacting protein VEGS01_06330 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) VEGS01_06340 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) VEGS01_06360 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) VEGS01_06370 ENOG4107QPK )-transporter VEGS01_06380 ENOG4107GFK fumarate VEGS01_06390 ENOG4106DSS Tartrate dehydratase subunit alpha VEGS01_06400 ENOG4105EJC lysr family transcriptional regulator VEGS01_06420 ENOG4107ZVW dihydroneopterin aldolase VEGS01_06450 ENOG4106MWK domain protein VEGS01_06460 ENOG4105I7R Adenylate cyclase VEGS01_06490 ENOG4107S78 Band 7 protein VEGS01_06500 ENOG4108MBK is1 orf2 VEGS01_06520 ENOG4105PV3 Inner membrane protein yqiJ VEGS01_06540 ENOG4108MY7 Fimbrial VEGS01_06550 ENOG4108TTM chaperone VEGS01_06570 ENOG4105H8W Fimbrial protein VEGS01_06580 ENOG4105W0Z cytoplasmic protein VEGS01_06620 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b VEGS01_06630 ENOG4106032 Glutathionylspermidine synthase VEGS01_06650 ENOG4105DFG type I secretion outer membrane protein VEGS01_06660 ENOG41087AY ADP-Ribose pyrophosphatase VEGS01_06670 ENOG4108SX3 cytoplasmic protein VEGS01_06680 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) VEGS01_06690 ENOG4105IPS esterase VEGS01_06700 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) VEGS01_06710 ENOG4105VRH Antibiotic biosynthesis monooxygenase VEGS01_06720 ENOG4105NF4 modulator of drug activity VEGS01_06730 ENOG4107DEU Inner membrane protein YgiZ VEGS01_06740 ENOG4105DHQ Histidine kinase VEGS01_06750 ENOG4105XJC Two component transcriptional regulator (Winged helix family VEGS01_06760 ENOG4105H4F exported protein VEGS01_06770 ENOG4105F4I Transcriptional regulator VEGS01_06780 ENOG4105RT5 Toxic component of a toxin-antitoxin (TA) module. An mRNA interferase which has been reported to be translation- independent (PubMed 19690171, PubMed 19943910) and translation- dependent (PubMed 20041169). Cleavage has been reported to occur on either side of G in the sequence GCU (PubMed 19690171) but also after C in GC(A U) sequences (PubMed 19943910). There are only 14 genes in E.coli W3110 (and probably also MG1655) that do not have a GCU sequence and thus are resistant to the mRNA interferase activity. Overexpression causes cessation of cell growth and inhibits cell proliferation via inhibition of translation as well as increasing persister cell formation VEGS01_06790 ENOG4105WJ3 XRE family Transcriptional regulator VEGS01_06800 ENOG4108J59 Extracellular solute-binding protein, family 5 VEGS01_06810 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) VEGS01_06820 ENOG4107S7E 1-acyl-sn-glycerol-3-phosphate acyltransferase VEGS01_06830 ENOG4107TZ2 Cell division protein that is required for growth during stress conditions. May be involved in protecting or stabilizing the divisomal assembly under conditions of stress (By similarity) VEGS01_06840 ENOG4105CCT upf0313 protein VEGS01_06860 ENOG4105ZKC Conserved Protein VEGS01_06870 ENOG4105CV8 reductase VEGS01_06880 ENOG4108I6A alcohol dehydrogenase VEGS01_06890 ENOG4105CF7 AraC family transcriptional regulator VEGS01_06900 ENOG4108K81 inner membrane protein YghB VEGS01_06910 ENOG4105C28 cystathionine VEGS01_06920 ENOG4105CWK Biopolymer transport protein, ExbB VEGS01_06930 ENOG4108ZZF transport protein (ExbD) VEGS01_06940 ENOG4105CYX Short-chain dehydrogenase reductase Sdr VEGS01_06960 ENOG4105CPC Aldo Keto reductase VEGS01_06980 ENOG410900S Protein of unknown function (DUF2623) VEGS01_06990 ENOG4105E3S small subunit VEGS01_07000 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein VEGS01_07010 ENOG4105CJ5 hydrogenase 2 b cytochrome subunit VEGS01_07020 ENOG4105DPX Hydrogenase, large subunit VEGS01_07030 ENOG4108USZ hydrogenase VEGS01_07040 ENOG4108WGS hydrogenase 2-specific chaperone VEGS01_07060 ENOG41082MF Hydrogenase assembly chaperone hypC hupF VEGS01_07070 ENOG4105CYM Glutathione S-transferase VEGS01_07080 ENOG4106032 Glutathionylspermidine synthase VEGS01_07100 ENOG4108MBK is1 orf2 VEGS01_07110 ENOG4105DFP Integrase VEGS01_07120 ENOG4108UQV Membrane VEGS01_07130 ENOG4105CXN decarboxylase VEGS01_07140 ENOG4105EAA nucleoside VEGS01_07170 ENOG4105CEN a g-specific adenine glycosylase VEGS01_07190 ENOG41090ED Protein with unknown function (DUF469) VEGS01_07200 ENOG4105K33 Periplasmic Protein VEGS01_07210 ENOG4105HDK L-asparaginase VEGS01_07220 ENOG4106MH3 alpha helix chain VEGS01_07230 ENOG4105CSA Coproporphyrinogen iii oxidase VEGS01_07240 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) VEGS01_07250 ENOG4105VZ9 UPF0235 protein VEGS01_07260 ENOG4108VIA integral membrane protein VEGS01_07270 ENOG4105DFA alanine racemase domain protein VEGS01_07280 ENOG4105CZX twitching motility protein VEGS01_07310 ENOG4105D7Z glutathione synthase VEGS01_07320 ENOG4105QF0 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) VEGS01_07330 ENOG4105RWS endonuclease I VEGS01_07350 ENOG4107QNK )-transporter VEGS01_07380 ENOG4105DP5 Catalyzes the biosynthesis of agmatine from arginine (By similarity) VEGS01_07400 ENOG4108K0D peptidase, M48 VEGS01_07410 ENOG4105CV1 Transketolase (EC 2.2.1.1) VEGS01_07420 ENOG4108X7Y Mannitol-specific cryptic phosphotransferase enzyme iia VEGS01_07430 ENOG4105CTS PTS system mannitol-specific VEGS01_07440 ENOG4105DXH Alcohol dehydrogenase zinc-binding domain protein VEGS01_07450 ENOG4108Q8A Fructose-1,6-bisphosphatase VEGS01_07460 ENOG4108R4K DNA-binding, transcriptional regulator VEGS01_07470 ENOG4107Z1W Fructose transport system kinase VEGS01_07500 ENOG4105D2N Aldolase VEGS01_07510 ENOG4105D64 Mechanosensitive ion channel VEGS01_07520 ENOG4108ZUB Lysine exporter protein (Lyse ygga) VEGS01_07530 ENOG4105MPN Membrane VEGS01_07540 ENOG4105DEQ transcriptional regulator VEGS01_07550 ENOG4105CYC Transferase VEGS01_07560 ENOG4108M7F enoyl-CoA hydratase isomerase VEGS01_07570 ENOG4105DJT lAO AO transport system ATPase VEGS01_07580 ENOG4105D5P Methylmalonyl-coA mutase VEGS01_07620 ENOG4108JQ1 Dehydrogenase VEGS01_07630 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase VEGS01_07660 ENOG4107RAQ aminopeptidase VEGS01_07670 ENOG4105D0A hydroxylase VEGS01_07680 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family VEGS01_07710 ENOG4105CBI The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor VEGS01_07720 ENOG4105CYX Short-chain dehydrogenase reductase Sdr VEGS01_07730 ENOG4105CS2 ec 3.2.1.21 VEGS01_07750 ENOG4108UT2 hemolysin iii VEGS01_07770 ENOG4105Y75 tpr repeat protein VEGS01_07780 ENOG4108YDB Toxic component of a toxin-antitoxin (TA) module. Overexpression leads to growth arrest after 5 hours, with initial elongation of cells, followed by swelling. The toxic effects are abrogated by coexpression with antitoxin CptB. Interacts with cytoskeletal proteins FtsZ and MreB VEGS01_07790 ENOG41071R3 Low-potential electron donor to a number of redox enzymes (By similarity) VEGS01_07800 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) VEGS01_07810 ENOG4105T95 Thiol disulfide interChange protein VEGS01_07820 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) VEGS01_07840 ENOG4105CRK lysyL-tRNA synthetase VEGS01_07860 ENOG4105C2W permease VEGS01_07870 ENOG4105BZ8 glutamate synthase VEGS01_07880 ENOG4108R8B oxidoreductase Fe-S subunit VEGS01_07890 ENOG4105C7N Xanthine uracil vitamin C permease VEGS01_07900 ENOG4107QUY Guanine deaminase VEGS01_07910 ENOG4105C2W permease VEGS01_07920 ENOG4105C7W Xanthine dehydrogenase VEGS01_07930 ENOG410873Y FAD binding domain in molybdopterin dehydrogenase VEGS01_07940 ENOG4107UUR Chlorohydrolase aminohydrolase VEGS01_07950 ENOG4105BZ8 glutamate synthase VEGS01_07960 ENOG4105MFX 4-diphosphocytidyl-2c-methyl-d-erythritol synthase VEGS01_07970 ENOG4105MJ6 selenium-dependent hydroxylase accessory protein YqeC VEGS01_07980 ENOG4107P0T Selenium-dependent molybdenum hydroxylase system protein, YqeB family VEGS01_07990 ENOG4105C5B carbamate kinase VEGS01_08010 ENOG4107S4Y M20 DapE family protein YgeY VEGS01_08020 ENOG4107RCH Diaminopropionate ammonia-lyase VEGS01_08030 ENOG4105IW6 Carbamoyltransferase VEGS01_08040 ENOG4108JUB Transcriptional regulator VEGS01_08050 ENOG4108UTP (2Fe-2S)-binding domain protein VEGS01_08060 ENOG4108HR6 Dehydrogenase VEGS01_08070 ENOG4105C7W Xanthine dehydrogenase VEGS01_08080 ENOG4108K5P (LipO)protein VEGS01_08130 ENOG4105FV3 VEGS01_08140 ENOG4108TC1 Transcriptional regulator VEGS01_08150 ENOG4105ISV protein with bipartite regulator domain VEGS01_08160 ENOG4108MHD transport protein VEGS01_08170 ENOG4105CHU acetyl-coa acetyltransferase VEGS01_08190 ENOG4105CHR reductase VEGS01_08200 ENOG4107QNK )-transporter VEGS01_08220 ENOG4105RQF LysR family Transcriptional regulator VEGS01_08240 ENOG41060NJ transcriptional regulator VEGS01_08250 ENOG4105CEY Amp-dependent synthetase and ligase VEGS01_08270 ENOG4105CPC Aldo Keto reductase VEGS01_08280 ENOG4105SUV lipoprotein YgdR VEGS01_08290 ENOG4105EE5 Membrane protein terC VEGS01_08330 ENOG4108HRM phosphoenolpyruvate--protein phosphotransferase VEGS01_08360 ENOG4105IPU prepilin peptidase dependent protein A VEGS01_08370 ENOG4105JCS prepilin peptidase dependent protein VEGS01_08380 ENOG4105SEN Protein of unknown function (DUF2509) VEGS01_08390 ENOG4105RVB Prepilin peptidase dependent protein c VEGS01_08400 ENOG4105DSY exodeoxyribonuclease V, gamma VEGS01_08410 ENOG4107QXK peptidase VEGS01_08420 ENOG4107QKA exodeoxyribonuclease V beta VEGS01_08430 ENOG4107QYX exodeoxyribonuclease v alpha VEGS01_08440 ENOG4108EKC n-acetylglutamate synthase VEGS01_08450 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase VEGS01_08460 ENOG4105CA3 membrane-bound lytic murein transglycosylase VEGS01_08470 ENOG4105CUZ uba thif-type nad fad binding protein VEGS01_08480 ENOG4105P9C Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity) VEGS01_08490 ENOG4105C9B Cysteine desulfurase VEGS01_08500 ENOG4105M5B (LipO)protein VEGS01_08510 ENOG4105ETT transcriptional Regulator, LysR family VEGS01_08520 ENOG4105M08 Membrane VEGS01_08540 ENOG4107EDW L-fucose operon activator VEGS01_08560 ENOG4105CMG Carbohydrate kinase VEGS01_08580 ENOG4105EDR glucose galactose transporter VEGS01_08590 ENOG4107W7X Aldolase VEGS01_08600 ENOG4105C0A alcohol dehydrogenase VEGS01_08620 ENOG4105EJQ L-serine dehydratase VEGS01_08630 ENOG4105C44 Serine transporter VEGS01_08640 ENOG4105EWT decarboxylase family VEGS01_08670 ENOG4105WP7 tRNA pseudouridine synthase C VEGS01_08680 ENOG4105DR9 pseudouridine synthase VEGS01_08690 ENOG4105QDK Flavodoxin VEGS01_08700 ENOG4105DJB Major Facilitator Superfamily VEGS01_08710 ENOG4105EQX glucarate dehydratase VEGS01_08720 ENOG4105EQX glucarate dehydratase VEGS01_08730 ENOG4105BZU Histidine kinase VEGS01_08740 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) VEGS01_08750 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) VEGS01_08760 ENOG4106A2Z transcriptional regulator antitoxin, MazE VEGS01_08770 ENOG4105MZG transcriptional modulator of maze toxin, mazf VEGS01_08780 ENOG4105DXN mazG family VEGS01_08810 ENOG4105HA9 of methanol dehydrogenase type VEGS01_08830 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) VEGS01_08840 ENOG4108CWB sugar kinase ygcE VEGS01_08850 ENOG4108ITV Inner membrane protein yqcE VEGS01_08860 ENOG4105CHR reductase VEGS01_08870 ENOG4107R3A FAD linked oxidase domain protein VEGS01_08880 ENOG4108MBK is1 orf2 VEGS01_08900 ENOG4107R3A FAD linked oxidase domain protein VEGS01_08910 ENOG4105C54 Major Facilitator superfamily VEGS01_08920 ENOG4106IKH Electron transfer flavoprotein VEGS01_08930 ENOG4105YBM electron transfer flavoprotein subunit ygcQ VEGS01_08940 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator VEGS01_08950 ENOG4105WQV ferredoxin-like protein VEGS01_08960 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase VEGS01_08970 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase VEGS01_08990 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) VEGS01_09010 ENOG4107635 Hok Gef family protein VEGS01_09020 ENOG4108SER Transposase VEGS01_09030 ENOG4105DTT CRISPR-associated helicase, cas3 VEGS01_09040 ENOG4105CYR Crispr-associated protein, cse1 family VEGS01_09060 ENOG41060M0 Crispr-associated protein, cse4 family VEGS01_09070 ENOG4108VWQ crispr-associated protein VEGS01_09090 ENOG4105TZK CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. May be involved in the integration of spacer DNA into the CRISPR cassette (By similarity) VEGS01_09100 ENOG4105PWE CRISPR-associated protein cas2 VEGS01_09110 ENOG4108MXK alkaline phosphatase isozyme conversion VEGS01_09120 ENOG4105C11 sulfate adenylyltransferase), subunit 2 VEGS01_09130 ENOG4105C3T may be the GTPase, regulating ATP sulfurylase activity (By similarity) VEGS01_09140 ENOG4108I67 Catalyzes the synthesis of activated sulfate (By similarity) VEGS01_09150 ENOG4105N0Z inner membrane protein ygbE VEGS01_09160 ENOG4105N0Z inner membrane protein ygbE VEGS01_09240 ENOG4108K5P (LipO)protein VEGS01_09250 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) VEGS01_09260 ENOG4105C6Z Gluconate VEGS01_09270 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) VEGS01_09280 ENOG4105FB2 class II Aldolase VEGS01_09290 ENOG4105G63 Type III effector Hrp-dependent VEGS01_09300 ENOG4105ZXK Dehydrogenase VEGS01_09310 ENOG4105MVE transcriptional regulator VEGS01_09320 ENOG4105MEW serine threonine protein phosphatase VEGS01_09350 ENOG4105VXR cytoplasmic protein VEGS01_09360 ENOG4108JUA Transcriptional regulator VEGS01_09370 ENOG4105C45 hydrogenase expression formation protein (HypE) VEGS01_09380 ENOG4105CQS hydrogenase expression formation protein HypD VEGS01_09390 ENOG41083WG hydrogenase assembly chaperone VEGS01_09400 ENOG4107RSS Hydrogenase accessory protein HypB VEGS01_09410 ENOG410816D Probably plays a role in a hydrogenase nickel cofactor insertion step (By similarity) VEGS01_09420 ENOG4108VRC Formate hydrogenlyase regulatory protein hycA VEGS01_09430 ENOG4108MFN small subunit of hydrogenase-3, iron-sulfur protein (part of formate hydrogenlyase (FHL) complex) VEGS01_09440 ENOG4107R30 NADH dehydrogenase VEGS01_09450 ENOG4107TDF Formate hydrogenlyase subunit 4 VEGS01_09460 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) VEGS01_09470 ENOG4108RG7 formate hydrogenlyase complex iron-sulfur subunit VEGS01_09480 ENOG4105C47 NADH ubiquinone oxidoreductase 20 kda subunit VEGS01_09490 ENOG4105I6X formate hydrogenlyase maturation VEGS01_09500 ENOG4108MG9 hydrogenase 3 maturation protease VEGS01_09510 ENOG4105CS2 ec 3.2.1.21 VEGS01_09520 ENOG4105C5Y PTS System VEGS01_09530 ENOG4105C5Y PTS System VEGS01_09540 ENOG4105DDV Transcriptional regulator (LacI family VEGS01_09550 ENOG4108RC0 Electron transport protein VEGS01_09560 ENOG4105C8H hydrogenase maturation protein Hypf VEGS01_09570 ENOG4108EQM faD-dependent pyridine nucleotide-disulfide oxidoreductase VEGS01_09590 ENOG4108JUA Transcriptional regulator VEGS01_09600 ENOG4105C2X Arabinose 5-phosphate isomerase VEGS01_09610 ENOG410804X Transcriptional regulator VEGS01_09620 ENOG4105J92 DNA-binding transcriptional activator GutM VEGS01_09630 ENOG4107QMF Sorbitol-6-phosphate dehydrogenase VEGS01_09640 ENOG4105VI0 Pts system, glucitol sorbitol-specific VEGS01_09650 ENOG4105DZY Pts system, glucitol sorbitol-specific VEGS01_09660 ENOG410787A Pts system, glucitol sorbitol-specific VEGS01_09670 ENOG4105CVE Lytic murein transglycosylase VEGS01_09680 ENOG4107TH8 cina domain protein VEGS01_09710 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) VEGS01_09720 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) VEGS01_09730 ENOG4107VXZ Hydrolase VEGS01_09740 ENOG4105W39 Membrane VEGS01_09770 ENOG4105C0R drug resistance transporter emrb qaca subfamily VEGS01_09780 ENOG4105CW7 secretion protein, HlyD family VEGS01_09790 ENOG4105NTK Transcriptional repressor Mpra VEGS01_09800 ENOG4105ZED uncharacterized protein ygaH VEGS01_09810 ENOG4108UMN azlc family VEGS01_09830 ENOG4105GIJ Glycine betaine VEGS01_09840 ENOG4108HQS Glycine betaine VEGS01_09850 ENOG4108IJ7 Glycine betaine VEGS01_09860 ENOG4107R25 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) VEGS01_09870 ENOG4107R25 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) VEGS01_09880 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) VEGS01_09900 ENOG4105WAZ (Glutaredoxin-like protein) NrdH VEGS01_09910 ENOG4108ZQZ Bacterial protein of unknown function (DUF883) VEGS01_09920 ENOG4108WMJ Protein of unknown function (DUF2002) VEGS01_09930 ENOG4108RNS Exports L-alanine (By similarity) VEGS01_09940 ENOG4108X73 DNA- binding protein VEGS01_09950 ENOG4108V62 Rhodanese domain protein VEGS01_09960 ENOG41080HT Transcriptional regulator, arsr family VEGS01_09970 ENOG4105VPI YqaE family transport protein VEGS01_09980 ENOG4109066 lysm domain bon superfamily protein VEGS01_09990 ENOG4108PVQ transcriptional regulator VEGS01_10000 ENOG4105C85 amino acid VEGS01_10010 ENOG4108JPW Aminotransferase VEGS01_10020 ENOG4105C26 Dehydrogenase VEGS01_10030 ENOG4105D5U fad dependent oxidoreductase VEGS01_10050 ENOG4105E54 alpha-amylase VEGS01_10060 ENOG4105E54 alpha-amylase VEGS01_10070 ENOG4105E54 alpha-amylase VEGS01_10100 ENOG4108MGN ATP-binding component of a transport system VEGS01_10110 ENOG4108X3P Toxic component of a toxin-antitoxin (TA) module. Overexpression results in inhibition of growth in liquid cultures VEGS01_10120 ENOG4105MAW Antitoxin component of a toxin-antitoxin (TA) module. Labile antitoxin that counteracts the effect of the CbtA (YeeV) toxin. It does not bind to the cognate toxin but instead binds to MreB and FtsZ (the toxin targets), enhancing their polymerization by forming higher-order bundles VEGS01_10130 ENOG4105ZS6 Protein of unknown function (DUF987) VEGS01_10140 ENOG4108XS9 dna repair protein VEGS01_10150 ENOG4105MFG Antirestriction protein VEGS01_10160 ENOG4106H6R UPF0380 protein VEGS01_10200 ENOG4108MXD gtp-binding protein VEGS01_10210 ENOG4108P8R VEGS01_10220 ENOG4105JXR Protein of unknown function (DUF3296) VEGS01_10230 ENOG4106QCB CP4-57 prophage VEGS01_10300 ENOG4105DFP Integrase VEGS01_10320 ENOG4108Z1B Cyclase dehydrase VEGS01_10340 ENOG4105YRI Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) VEGS01_10350 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) VEGS01_10380 ENOG4108JU6 CBS domain protein VEGS01_10390 ENOG4106KVJ cytochrome C assembly protein VEGS01_10410 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY VEGS01_10460 ENOG41090EK ompa motb domain protein VEGS01_10470 ENOG4108KHX Diguanylate cyclase VEGS01_10480 ENOG4108WS1 VEGS01_10490 ENOG4105QP9 Protein of unknown function (DUF2799) VEGS01_10500 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) VEGS01_10510 ENOG4105EHE chorismate mutase- prephenate dehydrogenase VEGS01_10520 ENOG4105CQC Prephenate dehydratase VEGS01_10530 ENOG4108WPH sigma 54 modulation protein ribosomal protein S30EA VEGS01_10540 ENOG4106SNF Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane VEGS01_10550 ENOG4105C34 Pseudouridine synthase VEGS01_10560 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase VEGS01_10570 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit VEGS01_10580 ENOG4105CSH Transporter VEGS01_10590 ENOG4105T42 (LipO)protein VEGS01_10600 ENOG4105JIM Phosphatidylserine synthase VEGS01_10610 ENOG4105CD5 CoA-binding domain protein VEGS01_10620 ENOG4106IUH DTW domain containing protein VEGS01_10630 ENOG4105K63 Thioredoxin VEGS01_10640 ENOG4105EIB trna rrna methyltransferase VEGS01_10680 ENOG41090KR LysR family transcriptional Regulator VEGS01_10690 ENOG4105C1J atp-dependent rna helicase VEGS01_10710 ENOG4108IYU L-aspartate oxidase VEGS01_10720 ENOG4105EMN RNA polymerase sigma factor VEGS01_10730 ENOG41069PW sigma-e factor negative regulatory protein VEGS01_10740 ENOG4105VQK sigma E regulatory protein, MucB RseB VEGS01_10750 ENOG4105WMJ Positive regulator of sigma E, RseC MucC VEGS01_10770 ENOG4105C3F Signal peptidase i VEGS01_10810 ENOG4105CSZ Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity) VEGS01_10830 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding VEGS01_10840 ENOG4106G6Q Transcriptional regulator VEGS01_10850 ENOG4105HYY HAD superfamily (Subfamily IF) hydrolase, YfhB VEGS01_10860 ENOG4108Z6B deaminase VEGS01_10880 ENOG4108ETH Formylglycinamide ribotide synthetase VEGS01_10890 ENOG4107WP9 Histidine kinase VEGS01_10910 ENOG4108SKK alpha helix protein VEGS01_10920 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family VEGS01_10940 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) VEGS01_10960 ENOG4108NZE NAGC-like transcriptional regulator VEGS01_10970 ENOG4107HQ7 repeat protein VEGS01_10980 ENOG4105FCA ABC transporter periplasmic-binding protein YphF VEGS01_10990 ENOG4108F37 ATP-binding component of a transport system VEGS01_11000 ENOG4105CNN ABC, transporter VEGS01_11010 ENOG4105CPQ Dehydrogenase VEGS01_11020 ENOG4108ZKT aldose 1-epimerase VEGS01_11030 ENOG4108SB3 DoxX Family VEGS01_11080 ENOG4105FUY alpha subunit VEGS01_11090 ENOG4108W5M transcriptional regulator VEGS01_11100 ENOG4105D8G Major Facilitator superfamily VEGS01_11110 ENOG4108MN2 Stationary phase inducible protein CsiE VEGS01_11120 ENOG4107XM9 (LipO)protein VEGS01_11130 ENOG4105ECY inositol monophosphatase VEGS01_11170 ENOG4107XTC May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins VEGS01_11210 ENOG4108ZIT Ferredoxin, 2FE-2S VEGS01_11220 ENOG4105WVQ Fe-S assembly protein IscX VEGS01_11240 ENOG4105YYA enhanced serine sensitivity protein SseB VEGS01_11250 ENOG4105KHC sulfurtransferase VEGS01_11260 ENOG4105DN3 alpha-2-macroglobulin domain protein VEGS01_11270 ENOG4108JQB penicillin-binding protein 1C VEGS01_11330 ENOG4105N21 Membrane VEGS01_11360 ENOG4105VPD cellular component movement VEGS01_11370 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) VEGS01_11380 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) VEGS01_11390 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) VEGS01_11400 ENOG41066DY Membrane VEGS01_11410 ENOG4108ZMA Outer membrane lipoprotein VEGS01_11420 ENOG41062G3 Protein of unknown function (DUF2633) VEGS01_11440 ENOG4105BZU Histidine kinase VEGS01_11450 ENOG4105C9X ppx gppa phosphatase VEGS01_11460 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) VEGS01_11470 ENOG4108V3E phosphoribosylglycinamide formyltransferase VEGS01_11500 ENOG4105C2W permease VEGS01_11510 ENOG4108KZ1 Mediates the interaction of DNA replication inititator protein DnaA with DNA polymerase subunit beta sliding clamp (dnaN). Stimulates hydrolysis of ATP-DnaA to ADP-DnaA, rendering DnaA inactive for reinititation, a process called regulatory inhibition of DnaA or RIDA (By similarity) VEGS01_11520 ENOG4105K89 arsenate reductase VEGS01_11530 ENOG4105ERG peptidase m48, ste24p VEGS01_11540 ENOG4105C02 permease VEGS01_11550 ENOG4105TMB Formate nitrite transporter VEGS01_11560 ENOG4108JUA Transcriptional regulator VEGS01_11570 ENOG4105I6X formate hydrogenlyase maturation VEGS01_11580 ENOG4105C47 NADH ubiquinone oxidoreductase 20 kda subunit VEGS01_11600 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) VEGS01_11610 ENOG4108JPZ Monovalent cation H antiporter subunit D VEGS01_11620 ENOG4107WQX hydrogenase 4 membrane subunit VEGS01_11630 ENOG4105D65 subunit l VEGS01_11640 ENOG4107TDF Formate hydrogenlyase subunit 4 VEGS01_11650 ENOG4107TDF Formate hydrogenlyase subunit 4 VEGS01_11660 ENOG4108JPZ Monovalent cation H antiporter subunit D VEGS01_11670 ENOG4108MFN small subunit of hydrogenase-3, iron-sulfur protein (part of formate hydrogenlyase (FHL) complex) VEGS01_11680 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen VEGS01_11690 ENOG4105RH4 Glycine cleavage system transcriptional repressor VEGS01_11710 ENOG4107EG0 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) VEGS01_11730 ENOG4105CGZ zinc metallopeptidase VEGS01_11750 ENOG4106KED esterase YpfH VEGS01_11780 ENOG4105KUZ arsenate reductase VEGS01_11790 ENOG4105BZS acriflavin resistance protein VEGS01_11800 ENOG4105BZU Histidine kinase VEGS01_11810 ENOG4105BZ8 glutamate synthase VEGS01_11830 ENOG4108PVD exported protein VEGS01_11840 ENOG4105CV1 Transketolase (EC 2.2.1.1) VEGS01_11850 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) VEGS01_11860 ENOG4105C6K Malic enzyme VEGS01_11870 ENOG4108VJN May be involved in the formation of a specific microcompartment in the cell in which the metabolism of potentially toxic by-products takes place VEGS01_11880 ENOG4106S4J ethanolamine utilization protein EutP VEGS01_11890 ENOG4105NDK ethanolamine utilization protein VEGS01_11900 ENOG4108PFF ethanolamine utilization cobalamin adenosyltransferase VEGS01_11910 ENOG4107WUY phosphate acetyltransferase VEGS01_11920 ENOG4105KNY Microcompartments protein VEGS01_11930 ENOG4105WVM ethanolamine utilization protein EutN carboxysome structural protein Ccml VEGS01_11940 ENOG4108EKI Dehydrogenase VEGS01_11950 ENOG4107RWI ethanolamine utilization protein eutJ VEGS01_11960 ENOG4105C0A alcohol dehydrogenase VEGS01_11970 ENOG4105ENY Ethanolamine utilization protein eutH VEGS01_11980 ENOG4105DYY Reactivating factor for ethanolamine ammonia lyase VEGS01_11990 ENOG4105CPD ethanolamine ammonia-lyase VEGS01_12010 ENOG4106D67 ethanolamine utilization protein VEGS01_12020 ENOG4108X49 Ethanolamine utilization protein EutK VEGS01_12030 ENOG4108K3Z AraC family transcriptional regulator VEGS01_12050 ENOG4108KNB n-acetylmuramoyl-l-alanine amidase VEGS01_12070 ENOG4105QZU Inner membrane protein YfeZ VEGS01_12080 ENOG4105E7K (LipO)protein VEGS01_12090 ENOG4105EZR dyp-type peroxidase family protein VEGS01_12100 ENOG4107S1E Beta-lactamase VEGS01_12110 ENOG4105C5Y PTS System VEGS01_12140 ENOG4105I7Z Short-chain dehydrogenase reductase Sdr VEGS01_12150 ENOG4108J2H Sulfate ABC transporter periplasmic sulfate-binding protein VEGS01_12160 ENOG4108I5D sulfate abc transporter VEGS01_12170 ENOG4105ECW sulfate abc transporter VEGS01_12180 ENOG4108IJ6 ABC transporter VEGS01_12190 ENOG4105C6T cysteine synthase VEGS01_12200 ENOG4105M0Y VEGS01_12220 ENOG4105C5Y PTS System VEGS01_12230 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) VEGS01_12250 ENOG4105C6T cysteine synthase VEGS01_12290 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) VEGS01_12300 ENOG4105VRT cytoplasmic protein VEGS01_12310 ENOG4105DHU Bile acid VEGS01_12320 ENOG4108M0I Transcriptional regulator VEGS01_12330 ENOG4108NFH Sugar hydrolase VEGS01_12340 ENOG4107U5R The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity) VEGS01_12350 ENOG4105EAA nucleoside VEGS01_12360 ENOG4105EAA nucleoside VEGS01_12380 ENOG4105CN8 Transcriptional regulator VEGS01_12400 ENOG4105GXM Putative transcription regulator (DUF1323) VEGS01_12410 ENOG4105HZG regulatoR VEGS01_12420 ENOG4108KMM Diguanylate cyclase VEGS01_12430 ENOG4108SER Transposase VEGS01_12440 ENOG4105D9N nucleoside VEGS01_12460 ENOG4109076 Conserved Protein VEGS01_12470 ENOG4105VCT ion-transport protein YfeO VEGS01_12490 ENOG4105R6B The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane (By similarity) VEGS01_12500 ENOG410863U PTS System VEGS01_12510 ENOG4105DC7 peptidase M24 VEGS01_12520 ENOG4105CN9 Peptidase m42 family protein VEGS01_12530 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) VEGS01_12540 ENOG4108CIP transcriptional regulator VEGS01_12550 ENOG4105DY9 regulatoR VEGS01_12560 ENOG4108HRK Histidine kinase VEGS01_12570 ENOG4105CHM Aminotransferase VEGS01_12580 ENOG4105D1S lipid A biosynthesis VEGS01_12590 ENOG4105W9M Membrane VEGS01_12610 ENOG4108V08 YfdX protein VEGS01_12630 ENOG4105CFN oxalyl-CoA decarboxylase VEGS01_12640 ENOG4108N2Y auxin Efflux VEGS01_12650 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F VEGS01_12660 ENOG4105BZU Histidine kinase VEGS01_12670 ENOG4108WQH regulatoR VEGS01_12680 ENOG4105CW7 secretion protein, HlyD family VEGS01_12690 ENOG4105C0R drug resistance transporter emrb qaca subfamily VEGS01_12710 ENOG4105C6Z Gluconate VEGS01_12720 ENOG4105W8I Transcriptional regulator VEGS01_12900 ENOG4105CKK Glycosyl transferase, family 2 VEGS01_12930 ENOG4105CKK Glycosyl transferase, family 2 VEGS01_12940 ENOG4105IHM Involved in O antigen modification. Involved in the translocation of bactoprenol-linked glucose across the cytoplasmic membrane (By similarity) VEGS01_12960 ENOG4105DFP Integrase VEGS01_12970 ENOG4105S64 Formate nitrite transporter VEGS01_12980 ENOG410903C (LipO)protein VEGS01_13000 ENOG4105CKF membrane protein involved in aromatic hydrocarbon degradation VEGS01_13010 ENOG4105KZW UPF0381 protein VEGS01_13040 ENOG4108BY2 phosphohistidine phosphatase VEGS01_13060 ENOG4106PG1 outer membrane usher protein VEGS01_13070 ENOG4108FZ9 Chaperone VEGS01_13080 ENOG4105NEV Fimbrial VEGS01_13090 ENOG4105UGQ Fimbrial VEGS01_13100 ENOG4105US4 fimbrial-like protein yfcP VEGS01_13130 ENOG4105C76 Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity) VEGS01_13150 ENOG4105HPZ Involved in the removal of murein from the sacculus. May also facilitate integration of nascent murein strands into the sacculus by cleaving the peptide bonds between neighboring strands in mature murein (By similarity) VEGS01_13160 ENOG4105EJ9 Membrane VEGS01_13170 ENOG4108BPE -transporting atpase VEGS01_13180 ENOG4105MH2 YfcL protein VEGS01_13200 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) VEGS01_13210 ENOG4105F9N Major Facilitator Superfamily VEGS01_13220 ENOG4106WZ1 flagella biosynthesis regulator VEGS01_13230 ENOG4105CJ0 Catalyzes the oxidation of erythronate-4-phosphate to 3- hydroxy-2-oxo-4-phosphonooxybutanoate (By similarity) VEGS01_13240 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) VEGS01_13260 ENOG4105DQR SNARE associated Golgi VEGS01_13280 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase VEGS01_13290 ENOG4108S3P Sporulation domain protein VEGS01_13300 ENOG4105E96 Colicin v production protein VEGS01_13310 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase VEGS01_13320 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase VEGS01_13330 ENOG4105E89 ABC transporter VEGS01_13340 ENOG4105E89 ABC transporter VEGS01_13350 ENOG4105DSP amino acid AbC transporter VEGS01_13360 ENOG4106YG3 ABC transporter VEGS01_13370 ENOG4108JEH abc transporter atp-binding protein VEGS01_13380 ENOG4105DNE Transposase VEGS01_13390 ENOG4105ECP epimerase VEGS01_13400 ENOG4105KKP D-erythro-7,8-dihydroneopterin triphosphate 2'-epimerase VEGS01_13410 ENOG4105CYM Glutathione S-transferase VEGS01_13420 ENOG4108SHQ Glutathione S-transferase VEGS01_13430 ENOG4108RE9 Phosphodiesterase VEGS01_13440 ENOG4105PTV Nudix Hydrolase VEGS01_13450 ENOG4105CSX c4-dicarboxylate anaerobic carrier VEGS01_13460 ENOG4105C6K Malic enzyme VEGS01_13470 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) VEGS01_13490 ENOG4105XWI UPF0304 protein VEGS01_13500 ENOG4105EVE HAD-superfamily hydrolase subfamily IA variant 3 VEGS01_13510 ENOG4107QWE )-transporter VEGS01_13530 ENOG4105CHM Aminotransferase VEGS01_13540 ENOG4107NQ8 LysR family Transcriptional regulator VEGS01_13570 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) VEGS01_13580 ENOG4105GKE subunit e VEGS01_13590 ENOG4107QIZ NADH dehydrogenase VEGS01_13600 ENOG4107R0R NADH dehydrogenase subunit g VEGS01_13630 ENOG4107UFS subunit j VEGS01_13650 ENOG4105D65 subunit l VEGS01_13660 ENOG4105C8S subunit m VEGS01_13680 ENOG4105GDX Domain of unknown function (DUF1877) VEGS01_13690 ENOG4107VAM peptidase, m28 VEGS01_13720 ENOG4105Z6G Protease that can act as an efficient and specific deubiquitinating enzyme in vitro. Does not possess desumoylating and deneddylating activities. The physiological substrate is VEGS01_13740 ENOG4107YB6 acetyltransferase, (GNAT) family VEGS01_13750 ENOG4105TNS Conserved Protein VEGS01_13760 ENOG4105E4F Isochorismate synthase VEGS01_13790 ENOG4108IPT Naphthoate synthase VEGS01_13800 ENOG4105DNI Converts SHCHC to OSB (By similarity) VEGS01_13810 ENOG4105CEY Amp-dependent synthetase and ligase VEGS01_13820 ENOG4106GZG polymyxin resistance protein B VEGS01_13850 ENOG4105SA9 Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity) VEGS01_13900 ENOG4108WMR Catalyzes the dephosphorylation of heptose(II) of the outer membrane lipopolysaccharide core (By similarity) VEGS01_13910 ENOG4108RJ7 Catalyzes the hydrolysis of nucleoside triphosphates, with a preference for pyrimidine deoxynucleoside triphosphates (dUTP, dTTP and dCTP) (By similarity) VEGS01_13920 ENOG4108UII YfaZ family VEGS01_13930 ENOG4108EWA cinA-like protein VEGS01_13940 ENOG4107258 Transcriptional regulator VEGS01_13950 ENOG4105CXK mandelate racemase muconate lactonizing VEGS01_13960 ENOG4105CSP Major Facilitator Superfamily VEGS01_13990 ENOG4105DNE Transposase VEGS01_14000 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) VEGS01_14020 ENOG4107R5Y anaerobic glycerol-3-phosphate dehydrogenase, subunit A VEGS01_14030 ENOG4105CXY transporter VEGS01_14040 ENOG4106MZZ glycerophosphoryl diester phosphodiesterase VEGS01_14050 ENOG4107R11 Transcriptional regulator VEGS01_14060 ENOG4105FQR PH-inducible protein involved in stress response VEGS01_14070 ENOG4105XPH Ferredoxin VEGS01_14080 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) VEGS01_14090 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) VEGS01_14100 ENOG4107GHC outer membrane autotransporter VEGS01_14120 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) VEGS01_14130 ENOG4107FKF Uncharacterized protein conserved in bacteria (DUF2138) VEGS01_14140 ENOG4108QJJ Protein of unknown function (DUF1175) VEGS01_14150 ENOG4105F9F transposase VEGS01_14160 ENOG4107S52 alpha-2-macroglobulin domain protein VEGS01_14170 ENOG41081SK signal peptide protein VEGS01_14180 ENOG4105EDV vault protein VEGS01_14190 ENOG4105CHU acetyl-coa acetyltransferase VEGS01_14200 ENOG4105CRW Short chain fatty acid transporter VEGS01_14210 ENOG4107QNJ CoA-transferase subunit B VEGS01_14220 ENOG4107QP7 CoA-transferase subunit A VEGS01_14230 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family VEGS01_14240 ENOG4105BZU Histidine kinase VEGS01_14250 ENOG4105BZU Histidine kinase VEGS01_14260 ENOG4105BZU Histidine kinase VEGS01_14270 ENOG41068CG regulatoR VEGS01_14280 ENOG4105E3G Phosphotransfer intermediate protein in two-component regulatory system with RcsBC VEGS01_14290 ENOG4105FCK Membrane VEGS01_14300 ENOG4105CJ2 (LipO)protein VEGS01_14320 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) VEGS01_14330 ENOG4105CF1 Alkylated DNA repair protein VEGS01_14340 ENOG4105IBP Cyclic peptide transporter VEGS01_14350 ENOG4105DWT malate dehydrogenase (quinone) VEGS01_14380 ENOG41061Q0 Assembly protein for periplasmic nitrate reductase VEGS01_14400 ENOG4108BGM Quinol dehydrogenase periplasmic component VEGS01_14410 ENOG4105GXZ Ferredoxin-type protein NapH VEGS01_14420 ENOG4108ZMS Electron transfer subunit of the periplasmic nitrate reductase complex NapAB (By similarity) VEGS01_14430 ENOG4105CUW cytochrome C-TYPE protein VEGS01_14440 ENOG4107EV4 once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system (By similarity) VEGS01_14450 ENOG4105CA5 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes (By similarity) VEGS01_14460 ENOG41060IM Heme exporter protein VEGS01_14470 ENOG4105X3C heme exporter protein VEGS01_14490 ENOG4105DA4 cytochrome c-type biogenesis protein VEGS01_14500 ENOG4107QX9 Thiol disulfide interChange protein VEGS01_14510 ENOG4105KWW Biogenesis protein VEGS01_14520 ENOG4105WH1 Two component transcriptional regulator luxr family VEGS01_14530 ENOG4108MGN ATP-binding component of a transport system VEGS01_14540 ENOG4105E68 Sulfatase VEGS01_14580 ENOG4105CFI type iii restriction protein res subunit VEGS01_14590 ENOG4105I08 Pseudouridine synthase VEGS01_14600 ENOG4105C2C drug resistance transporter, Bcr CflA VEGS01_14610 ENOG4105HG6 VEGS01_14620 ENOG4108JQ5 ABC transporter VEGS01_14630 ENOG4108IYQ Binding-protein-dependent transport systems inner membrane component VEGS01_14640 ENOG4108I5X binding-protein-dependent transport systems inner membrane Component VEGS01_14650 ENOG4105E43 Extracellular solute-binding protein, family 5 VEGS01_14660 ENOG4105CXC rtn protein VEGS01_14670 ENOG4107TT5 NLP P60 protein VEGS01_14680 ENOG41076MN Phosphoesterase, PA-phosphatase related VEGS01_14690 ENOG4105CKI cobalamin synthesis protein VEGS01_14700 ENOG4105DEI Mannitol dehydrogenase VEGS01_14720 ENOG4105KRS Proteinase inhibitor VEGS01_14730 ENOG4105S8Q sugar efflux transporter VEGS01_14740 ENOG4105DTZ bifunctional PTS system fructose-specific transporter subunit IIA HPr protein VEGS01_14750 ENOG4105DE4 1-phosphofructokinase VEGS01_14760 ENOG4105DM4 PTS System VEGS01_14780 ENOG4105D53 Catalyzes the hydrolysis of pseudouridine 5'-phosphate (PsiMP) to ribose 5-phosphate and uracil (By similarity) VEGS01_14790 ENOG4105D9N nucleoside VEGS01_14800 ENOG4108Y4K DNA-binding transcriptional activator VEGS01_14820 ENOG4105D9N nucleoside VEGS01_14830 ENOG4105DD7 kinase (PfkB family VEGS01_14850 ENOG4105HMI Membrane VEGS01_14860 ENOG4105DUM transcriptional regulator, lysR family VEGS01_14870 ENOG4108IQI permease VEGS01_14880 ENOG4105D05 Receptor VEGS01_14910 ENOG4105DHF Membrane VEGS01_14930 ENOG41060NJ transcriptional regulator VEGS01_14940 ENOG4105EMA Periplasmic binding protein LacI transcriptional regulator VEGS01_14950 ENOG4105C2J ABC transporter VEGS01_14960 ENOG4108HWV )-transporter VEGS01_14970 ENOG4107SJI Dehydrogenase VEGS01_14980 ENOG4105BZ8 glutamate synthase VEGS01_14990 ENOG4105Y9N Membrane VEGS01_15000 ENOG4107GZ4 SanA protein VEGS01_15020 ENOG41067MG lrgb family VEGS01_15090 ENOG4105MSY salicylate hydroxylase VEGS01_15100 ENOG4105FBT Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity) VEGS01_15110 ENOG4105ETP RND efflux system, outer membrane lipoprotein VEGS01_15120 ENOG4105H9W Short-chain dehydrogenase reductase Sdr VEGS01_15130 ENOG4105KHU inner membrane protein YohD VEGS01_15140 ENOG41069YE inner membrane protein yohC VEGS01_15150 ENOG41061WM D-Alanyl-D-Alanine VEGS01_15160 ENOG4105CXG d-lactate dehydrogenase VEGS01_15170 ENOG4107QK4 glycoside hydrolase, family 3 domain protein VEGS01_15180 ENOG4107SI7 Substrate-binding region of abc-type glycine betaine transport system VEGS01_15190 ENOG4107T5X Binding-protein-dependent transport systems, inner membrane component VEGS01_15200 ENOG4108IJ8 ABC transporter VEGS01_15210 ENOG4105WJV Binding-protein-dependent transport systems, inner membrane component VEGS01_15220 ENOG4108XDN Transcriptional regulator VEGS01_15230 ENOG4108HRK Histidine kinase VEGS01_15240 ENOG4108NEV two component transcriptional regulator, LytTR family VEGS01_15250 ENOG4108W15 Protein of unknown function (DUF1456) VEGS01_15260 ENOG4108YCW (LipO)protein VEGS01_15270 ENOG410903U zinc ion binding VEGS01_15280 ENOG4105DEG Vwa containing coxe family protein VEGS01_15290 ENOG4105RD5 VEGS01_15300 ENOG4105KKX ATPase associated with various cellular activities aaa_5 VEGS01_15320 ENOG4108KDT Molybdate metabolism regulator VEGS01_15330 ENOG4108KDT Molybdate metabolism regulator VEGS01_15350 ENOG4105D1F ATP-binding protein VEGS01_15360 ENOG41067AK Protein of unknown function (DUF2574) VEGS01_15370 ENOG41063W2 Fimbrial protein VEGS01_15380 ENOG4108MQF Chaperone VEGS01_15390 ENOG4105CW0 outer membrane usher protein VEGS01_15400 ENOG410662B Type-1 fimbrial protein VEGS01_15410 ENOG4108Z1S Influences nickel and cobalt homeostasis. May act by modulating RcnA-mediated export of these ions to avoid excess efflux. Not involved in nickel import and does not bind nickel or cobalt ions directly VEGS01_15420 ENOG41061MD high-affinity nickel-transporter VEGS01_15450 ENOG4105DWF phosphomethylpyrimidine kinase VEGS01_15460 ENOG4108UQ1 hydrolase, family 25 VEGS01_15470 ENOG4105FDP GntR family transcriptional regulator VEGS01_15480 ENOG4108TFM Kinase, PfkB family VEGS01_15490 ENOG4108KD5 ADP-ribosylation crystallin J1 VEGS01_15500 ENOG4105EAA nucleoside VEGS01_15510 ENOG4105EIE fructose-bisphosphate aldolase VEGS01_15540 ENOG41082GB PTS system galactitol-specific transporter subunit IIA VEGS01_15550 ENOG41090UW PTS System VEGS01_15560 ENOG4105DT3 PTS system, galactitol-specific IIc component VEGS01_15570 ENOG4107WTH Galactitol-1-phosphate dehydrogenase VEGS01_15600 ENOG41076Z6 Uncharacterized protein yegR VEGS01_15610 ENOG4105CFP Peptidase U32 VEGS01_15630 ENOG4105X54 addiction module antidote protein VEGS01_15640 ENOG4105KWI UPF0339 protein VEGS01_15650 ENOG4105E3W Two component transcriptional regulator (Winged helix family VEGS01_15660 ENOG4105EB3 Histidine kinase VEGS01_15710 ENOG4108M24 von Willebrand factor, type A VEGS01_15720 ENOG4105UM3 Inherit from NOG: serine threonine phosphoprotein phosphatase VEGS01_15730 ENOG4106E1W protein with protein kinase and helix-hairpin-helix DNA-binding VEGS01_15740 ENOG4105R8A Heat shock protein VEGS01_15750 ENOG4105D03 DNA-3-methyladenine glycosylase II VEGS01_15760 ENOG4105BZU Histidine kinase VEGS01_15770 ENOG4105DBI uridine monophosphokinase VEGS01_15790 ENOG4108GAE asmA family VEGS01_15800 ENOG4105EE5 Membrane protein terC VEGS01_15820 ENOG4105DAY polysaccharide export protein VEGS01_15830 ENOG4105KJF protein tyrosine phosphatase VEGS01_15840 ENOG4105D75 Capsular exopolysaccharide family VEGS01_15850 ENOG41090RK glycosyl transferase VEGS01_15860 ENOG41068PY Colanic acid biosynthesis acetyltransferase wcaB VEGS01_15870 ENOG4107RXY Glycosyl transferase VEGS01_15880 ENOG4108NYJ Colanic acid VEGS01_15890 ENOG4105ECJ Glycosyl Transferase VEGS01_15900 ENOG4108Z90 colanic acid biosynthesis acetyltransferase wcaF VEGS01_15910 ENOG4105C0K Gdp-mannose 4,6-dehydratase VEGS01_15920 ENOG4105C30 Nad-dependent epimerase dehydratase VEGS01_15930 ENOG4105FGF GDP-mannose mannosyl hydrolase VEGS01_15940 ENOG4106CD9 glycosyl transferase group 1 VEGS01_15950 ENOG4105CJT Mannose-1-phosphate guanylyltransferase VEGS01_15960 ENOG4107QKV phosphomannomutase VEGS01_15970 ENOG4105D3Q Sugar transferase VEGS01_15980 ENOG4105PSV Polysaccharide Biosynthesis Protein VEGS01_15990 ENOG4105C74 pyruvyl transferase VEGS01_16000 ENOG4107T8Q Glycosyl transferase (Group 1 VEGS01_16010 ENOG4105G1A colanic acid biosynthesis protein VEGS01_16020 ENOG4105DMT epimerase dehydratase VEGS01_16030 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase VEGS01_16040 ENOG4105CMR udp-glucose 4-epimerase VEGS01_16050 ENOG4108MBK is1 orf2 VEGS01_16070 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) VEGS01_16080 ENOG4105C6Y Udp-glucose 6-dehydrogenase VEGS01_16090 ENOG4108KPN Confers a modal distribution of chain length on the O- antigen component of lipopolysaccharide (LPS). Gives rise to a reduced number of short chain molecules and increases in numbers of longer molecules, with a modal value of 13 (in strain O111 M92) and of 17 (in strain K12) VEGS01_16130 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) VEGS01_16140 ENOG4105ECC imidazole-glycerol-phosphate dehydratase VEGS01_16160 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) VEGS01_16180 ENOG4105VTW prevent-host-death family VEGS01_16190 ENOG4105KRQ Addiction module toxin, Txe YoeB family VEGS01_16200 ENOG4107SRH Nad-dependent epimerase dehydratase VEGS01_16210 ENOG4105EQ1 Transcriptional regulator VEGS01_16220 ENOG4105CUB amino acid VEGS01_16230 ENOG4105CUC YeeE YedE family protein VEGS01_16250 ENOG4105CJB Exodeoxyribonuclease I VEGS01_16260 ENOG4105DZ1 carboxypeptidase VEGS01_16280 ENOG4105DR8 Membrane VEGS01_16320 ENOG4105MAW Antitoxin component of a toxin-antitoxin (TA) module. Labile antitoxin that counteracts the effect of the CbtA (YeeV) toxin. It does not bind to the cognate toxin but instead binds to MreB and FtsZ (the toxin targets), enhancing their polymerization by forming higher-order bundles VEGS01_16340 ENOG4108YGG dna repair protein VEGS01_16350 ENOG4105MFG Antirestriction protein VEGS01_16360 ENOG4106H6R UPF0380 protein VEGS01_16400 ENOG4108YIV VEGS01_16410 ENOG4108F5E vimentin VEGS01_16520 ENOG41080QX K07048 phosphotriesterase-related protein VEGS01_16580 ENOG4108YZT Adenosylcobinamide kinase VEGS01_16610 ENOG4108PXI ErfK YbiS YcfS YnhG VEGS01_16620 ENOG4106P55 Transcriptional regulator VEGS01_16630 ENOG4107R11 Transcriptional regulator VEGS01_16640 ENOG4105UQX Mate efflux family protein VEGS01_16650 ENOG4105CDY transcriptional regulatory protein VEGS01_16660 ENOG4105FYV Amp nucleosidase VEGS01_16670 ENOG4105CSH Transporter VEGS01_16700 ENOG4108MBK is1 orf2 VEGS01_16720 ENOG4105TNG K13735 adhesin invasin VEGS01_16740 ENOG4108VKM cytochrome b561 VEGS01_16760 ENOG4108MEK Metal-binding protein YodA VEGS01_16780 ENOG4105CCD The exact function is not known. Can catalyze the reduction of a variety of substrates like dimethyl sulfoxide, trimethylamine N-oxide, phenylmethyl sulfoxide and L-methionine sulfoxide. Cannot reduce cyclic N-oxides. Shows no activity as sulfite oxidase (By similarity) VEGS01_16790 ENOG4105VT2 5-hydroxyisourate hydrolase VEGS01_16800 ENOG4105CK6 Two component transcriptional regulator (Winged helix family VEGS01_16810 ENOG4107ZY3 Histidine kinase VEGS01_16820 ENOG4105TMR Functions as a holding molecular chaperone (holdase) which stabilizes unfolding intermediates and rapidly releases them in an active form once stress has abated. Plays an important role in protecting cells from severe heat shock and starvation, as well as in acid resistance of stationary-phase cells. It catalyzes the conversion of methylglyoxal (MG) to D-lactate in a single glutathione (GSH)-independent step (By similarity) VEGS01_16840 ENOG4105FCK Membrane VEGS01_16850 ENOG4105Y0K Inner membrane protein YedR VEGS01_16860 ENOG4105EST Metal Dependent Phosphohydrolase VEGS01_16870 ENOG4105DVF Cytosine-specific methyltransferase VEGS01_16880 ENOG41090BB DNA mismatch endonuclease (vsr) VEGS01_16890 ENOG4105FDR Membrane VEGS01_16900 ENOG4105CKW Inner membrane protein yedI VEGS01_16910 ENOG4105VNZ cytoplasmic protein VEGS01_16920 ENOG4105BZU Histidine kinase VEGS01_16940 ENOG4105YX3 cellular response to acidity VEGS01_16960 ENOG4107TKS colanic acid capsular biosynthesis activation protein A VEGS01_16970 ENOG4105D19 Role in flagellar biosynthesis (By similarity) VEGS01_16990 ENOG4105CN7 Flagellar biosynthetic protein FliP VEGS01_17000 ENOG4105K0P flagellar biosynthesis protein VEGS01_17010 ENOG4105DD5 Flagellar motor switch protein VEGS01_17020 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) VEGS01_17030 ENOG4107ZI8 flagellar basal body-associated protein flil VEGS01_17040 ENOG4105WF4 Flagellar hook-length control protein VEGS01_17050 ENOG4105GSA Flagellar export protein flij VEGS01_17060 ENOG4108JIR Flagellum-specific ATP synthase VEGS01_17070 ENOG41090PJ Flagellar assembly protein VEGS01_17080 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) VEGS01_17090 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) VEGS01_17100 ENOG4105VQ0 flagellar hook-basal body complex protein fliE VEGS01_17110 ENOG4108RAV Conserved protein VEGS01_17130 ENOG41066VF YeeE YedE family protein VEGS01_17140 ENOG4108W9D (LipO)protein VEGS01_17150 ENOG4105E5K Alpha-amylase VEGS01_17170 ENOG4105MQ3 flagellar protein FliS VEGS01_17180 ENOG4105DTS flagellar hook-associated VEGS01_17190 ENOG4105I03 Flagellin VEGS01_17200 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) VEGS01_17210 ENOG4108M9K flagella biosynthesis protein FliZ VEGS01_17220 ENOG4105EAB amino acid AbC transporter VEGS01_17230 ENOG4105K6H D-cysteine desulfhydrase VEGS01_17240 ENOG4105E5Q amino acid AbC transporter VEGS01_17250 ENOG4105CDA abc transporter atp-binding protein VEGS01_17260 ENOG4105VJY transcriptional regulator VEGS01_17270 ENOG4105XVG cytoplasmic protein VEGS01_17280 ENOG4105WH1 Two component transcriptional regulator luxr family VEGS01_17290 ENOG4105CII The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity) VEGS01_17310 ENOG4106RHG Yeca family VEGS01_17320 ENOG4105E0U tyrosine-specific transport protein VEGS01_17330 ENOG4105VVZ metal-binding protein VEGS01_17340 ENOG41090A1 ferritin VEGS01_17360 ENOG4105N4N Protein of unknown function (DUF2766) VEGS01_17370 ENOG4108UEC Ferritin-like protein VEGS01_17380 ENOG4105DMK Periplasmic binding protein LacI transcriptional regulator VEGS01_17390 ENOG4105C2J ABC transporter VEGS01_17400 ENOG4105CNN ABC, transporter VEGS01_17410 ENOG4108K4C ec 3.1.3.12 VEGS01_17430 ENOG4108VA4 Universal stress protein VEGS01_17450 ENOG4106CIA Functions in complex with FlhD as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region VEGS01_17460 ENOG4107RD7 Flagellar Motor Protein, MotA VEGS01_17470 ENOG4105ER2 Ompa motb domain protein VEGS01_17480 ENOG4105CBS Chea signal transduction histidine kinase VEGS01_17490 ENOG4108V3W Chemotaxis protein, CheW VEGS01_17500 ENOG4105C8Q Methyl-accepting chemotaxis VEGS01_17510 ENOG4105C8Q Methyl-accepting chemotaxis VEGS01_17520 ENOG4105BZU Histidine kinase VEGS01_17540 ENOG4108VYJ response regulator receiver protein VEGS01_17550 ENOG4108KCC Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P) (By similarity) VEGS01_17560 ENOG4105D00 flagellar biosynthetic protein flhB VEGS01_17570 ENOG4105D7B Flagellar biosynthesis protein flha VEGS01_17580 ENOG4105W13 flagellar protein VEGS01_17600 ENOG4105C75 arginyL-tRNA synthetase VEGS01_17610 ENOG4106ZCM YecM protein VEGS01_17630 ENOG4105CUW cytochrome C-TYPE protein VEGS01_17640 ENOG4107QY8 reductase VEGS01_17660 ENOG4105DA6 Catalyzes the conversion of 5-methoxyuridine (mo5U) to uridine-5-oxyacetic acid (cmo5U) at position 34 in tRNA. May also participate in the methylation of uridine-5-oxyacetic acid (cmo5U) to uridine-5-oxyacetic acid methyl ester (mcmo5U) (By similarity) VEGS01_17670 ENOG4105WJG Glutathione VEGS01_17680 ENOG41081XQ Conserved Protein VEGS01_17690 ENOG4105D3W isochorismatase VEGS01_17710 ENOG4108TIT dATP pyrophosphohydrolase VEGS01_17720 ENOG4105CDY transcriptional regulatory protein VEGS01_17740 ENOG4107S01 Repressor protein MetJ VEGS01_17770 ENOG4105FAV ABC, transporter VEGS01_17790 ENOG4105NXV High-affinity zinc uptake system protein VEGS01_17800 ENOG4105DR5 peptidase VEGS01_17810 ENOG4105NWR lipid A biosynthesis (Kdo)2-(Lauroyl)-lipid IVA acyltransferase VEGS01_17820 ENOG4105CA9 Pyruvate kinase VEGS01_17830 ENOG4106KNT transcriptional regulator VEGS01_17850 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase VEGS01_17860 ENOG4105C01 Dihydroxy-acid dehydratase VEGS01_17870 ENOG4108UHU Aldolase VEGS01_17880 ENOG4108HH9 Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR VEGS01_17890 ENOG4105X2V dna damage-inducible protein VEGS01_17910 ENOG4108Q2J Inner membrane protein YebE VEGS01_17920 ENOG4105CUG Oligopeptidase b VEGS01_17930 ENOG4105UMD exodeoxyribonuclease X VEGS01_17940 ENOG4108YGA nitrilase cyanide hydratase and apolipoprotein n-acyltransferase VEGS01_17950 ENOG4105MPK DNA polymerase III subunit theta VEGS01_17960 ENOG4105FXM Copper resistance protein VEGS01_17970 ENOG4108PNC copper resistance VEGS01_17980 ENOG4105NKT exported protein VEGS01_17990 ENOG4108R1E Serine threonine protein phosphatase 1 VEGS01_18000 ENOG4105UVW uncharacterized protein yebW VEGS01_18010 ENOG4105WT8 Protein of unknown function (DUF1480) VEGS01_18030 ENOG4105DY2 Paraquat-inducible protein b VEGS01_18040 ENOG4105H2K paraquat-inducible protein a VEGS01_18050 ENOG4108ZGC gaf domain protein VEGS01_18070 ENOG4105CN1 protease VEGS01_18090 ENOG4105C0R drug resistance transporter emrb qaca subfamily VEGS01_18100 ENOG4105J4Q Transcriptional regulator VEGS01_18110 ENOG4105TIK VEGS01_18120 ENOG4105Q3Y exported protein VEGS01_18140 ENOG4105DHI Methyltransferase VEGS01_18170 ENOG4105F3R pts system mannose fructose sorbose family iid VEGS01_18180 ENOG4105ETZ PTS System VEGS01_18190 ENOG4105DAS pts system VEGS01_18200 ENOG4105EE5 Membrane protein terC VEGS01_18210 ENOG4107XTP (EAL) domain protein VEGS01_18220 ENOG4105EJQ L-serine dehydratase VEGS01_18240 ENOG4105CRQ synthase (Component I) VEGS01_18260 ENOG4105V2F Uncharacterized protein yoac VEGS01_18280 ENOG4105M4H endoribonuclease L-psp VEGS01_18290 ENOG4105DVT helicase VEGS01_18300 ENOG41072GX Peptidase M22 Glycoprotease VEGS01_18310 ENOG4105Y4Z Outer Membrane Lipoprotein VEGS01_18320 ENOG4105CEY Amp-dependent synthetase and ligase VEGS01_18330 ENOG4105ZIE Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity) VEGS01_18340 ENOG4105E3J oxidoreductase VEGS01_18350 ENOG4105DVW rieske (2Fe-2S) VEGS01_18360 ENOG4105C94 Transporter VEGS01_18370 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) VEGS01_18380 ENOG4105EJC lysr family transcriptional regulator VEGS01_18400 ENOG4108YS1 cytoplasmic protein VEGS01_18410 ENOG4105YP6 Domain of unknown function (DUF1869) VEGS01_18420 ENOG4105Y3U Transglycosylase-associated protein VEGS01_18430 ENOG410620I Diguanylate cyclase VEGS01_18440 ENOG4105UCG Domain of unknown function (DUF333) VEGS01_18450 ENOG4105K78 MarR family Transcriptional regulator VEGS01_18460 ENOG4105DJ2 Major Facilitator Superfamily VEGS01_18470 ENOG4105R1U AraC Family Transcriptional Regulator VEGS01_18490 ENOG4108KXH Ybak prolyl-tRNA synthetase associated VEGS01_18500 ENOG4108KHP Diguanylate cyclase VEGS01_18510 ENOG4106KTS Inner membrane protein yeaI VEGS01_18520 ENOG4106AKX UPF0229 protein VEGS01_18530 ENOG4105CYN Serine protein kinase VEGS01_18540 ENOG4105GNX MltA-interacting MipA family protein VEGS01_18550 ENOG4105CV8 reductase VEGS01_18560 ENOG4105DSB aldose 1-epimerase VEGS01_18570 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase VEGS01_18590 ENOG4105VUT cytoplasmic protein VEGS01_18600 ENOG4105CPQ Dehydrogenase VEGS01_18610 ENOG4107TE1 transport protein VEGS01_18620 ENOG4108MBK is1 orf2 VEGS01_18630 ENOG4107UH8 sugar kinase VEGS01_18640 ENOG4105CPC Aldo Keto reductase VEGS01_18650 ENOG4105E98 transcriptional regulator DeoR family VEGS01_18660 ENOG4108KUU Inner membrane metabolite transport protein ydjE VEGS01_18670 ENOG4108KUU Inner membrane metabolite transport protein ydjE VEGS01_18680 ENOG4108RWI nicotinamidase VEGS01_18690 ENOG4105HDK L-asparaginase VEGS01_18700 ENOG4105D07 Signal peptide peptidase, SppA VEGS01_18710 ENOG41069NU Nitroreductase VEGS01_18730 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) VEGS01_18740 ENOG41065FB inner membrane protein ynji VEGS01_18750 ENOG4105D82 Glutamate dehydrogenase VEGS01_18760 ENOG4105MTM Protein of unknown function (DUF1496) VEGS01_18770 ENOG4105M6F mutator MutT protein VEGS01_18780 ENOG4108T9J Cdp-alcohol phosphatidyltransferase VEGS01_18790 ENOG4107RM6 sulfurtransferase VEGS01_18800 ENOG4108VGW abc transporter atp-binding protein VEGS01_18810 ENOG4105CXZ ABC transporter, permease VEGS01_18820 ENOG4105VNH ABC transporter solute-binding protein VEGS01_18830 ENOG4107ZN8 Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) VEGS01_18840 ENOG4108N5C SNARE associated Golgi protein-related protein VEGS01_18850 ENOG4108KCW iron-sulfur cluster binding VEGS01_18860 ENOG4108RSN SNARE associated Golgi VEGS01_18870 ENOG4105CGK Exodeoxyribonuclease III VEGS01_18910 ENOG4105EY2 Catalyzes the hydrolysis of N(2)-succinylarginine into N(2)-succinylornithine, ammonia and CO(2) (By similarity) VEGS01_18930 ENOG4108SPG Periplasmic Protein VEGS01_18950 ENOG4105DKD Incises the DNA at the 3' side of a lesion during nucleotide excision repair. Incises the DNA farther away from the lesion than UvrC. Not able to incise the 5' site of a lesion. When a lesion remains because UvrC is not able to induce the 3' incision, Cho incises the DNA. Then UvrC makes the 5' incision. The combined action of Cho and UvrC broadens the substrate range of nucleotide excision repair (By similarity) VEGS01_18970 ENOG4105KKI DNA-binding transcriptional activator OsmE VEGS01_18980 ENOG4105VZJ PTS System VEGS01_19010 ENOG410901P UPF0249 protein VEGS01_19020 ENOG4105CH6 catalase VEGS01_19050 ENOG4108ETY sodium dicarboxylate symporter VEGS01_19060 ENOG4107K5X Membrane-bound metal-dependent hydrolase VEGS01_19070 ENOG4107UW8 HAD-superfamily hydrolase subfamily IA variant 3 VEGS01_19080 ENOG4107PN8 YfeABCD locus regulator VEGS01_19100 ENOG4105P10 Uncharacterized protein ydiZ VEGS01_19110 ENOG4105DE4 1-phosphofructokinase VEGS01_19120 ENOG4108NE3 Salt-induced outer membrane protein VEGS01_19160 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) VEGS01_19170 ENOG41082NX 50s ribosomal protein l35 VEGS01_19230 ENOG4108V06 Glutathione peroxidase VEGS01_19250 ENOG4108QBX (LipO)protein VEGS01_19260 ENOG4108TC0 Diguanylate phosphodiesterase VEGS01_19290 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) VEGS01_19310 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) VEGS01_19320 ENOG4105CEY Amp-dependent synthetase and ligase VEGS01_19330 ENOG41090P5 ferredoxin-like protein VEGS01_19340 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase VEGS01_19350 ENOG4105C10 Electron transfer flavoprotein VEGS01_19360 ENOG4105CV7 Electron transfer flavoprotein VEGS01_19370 ENOG4105W4W Transcriptional regulator VEGS01_19380 ENOG4105C1G acyl-Coa dehydrogenase VEGS01_19390 ENOG4107R0K CoA transferase having broad substrate specificity for short-chain acyl-CoA thioesters with the activity decreasing when the length of the carboxylic acid chain exceeds four carbons (By similarity) VEGS01_19420 ENOG4105EMV Major Facilitator VEGS01_19430 ENOG4105EMV Major Facilitator VEGS01_19440 ENOG4105SUA Ydil protein VEGS01_19450 ENOG4105IPI Membrane VEGS01_19460 ENOG4105CQB FAD linked oxidase domain protein VEGS01_19470 ENOG4105KA0 thioesterase Superfamily protein VEGS01_19480 ENOG410671Z uncharacterized protein ydiH VEGS01_19490 ENOG4108Z4V iron-sulfur cluster assembly VEGS01_19500 ENOG4105DIW FeS assembly protein SUFB VEGS01_19510 ENOG4105C3K feS assembly ATPase SufC VEGS01_19520 ENOG4105JRK feS assembly protein SufD VEGS01_19550 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein VEGS01_19560 ENOG4105KMX major outer membrane lipoprotein VEGS01_19570 ENOG4105CA9 Pyruvate kinase VEGS01_19580 ENOG4105RFR Protein of unknown function (DUF2767) VEGS01_19590 ENOG4108PU5 4fe-4S ferredoxin, iron-sulfur binding domain protein VEGS01_19600 ENOG4105WE2 aldehyde ferredoxin oxidoreductase VEGS01_19610 ENOG4105JVW VEGS01_19620 ENOG4108393 oxidoreductase Fe-S subunit VEGS01_19630 ENOG4108NWD Cytochrome VEGS01_19640 ENOG4108Y7C Conserved Protein VEGS01_19650 ENOG4108KTU conserved protein with FAD NAD(P)-binding domain VEGS01_19660 ENOG4105N0V mono-oxygenase ydhR VEGS01_19690 ENOG4108R6K riboflavin synthase, subunit alpha VEGS01_19700 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase VEGS01_19710 ENOG4105CZQ inner membrane transport protein YdhC VEGS01_19720 ENOG4105F52 Transcriptional regulator VEGS01_19740 ENOG4105F27 Major Facilitator VEGS01_19750 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) VEGS01_19760 ENOG4105K4H Nlp p60 protein VEGS01_19790 ENOG4105M2J Glutaredoxin VEGS01_19800 ENOG4107QRT dEAD DEAH box helicase VEGS01_19810 ENOG4105DH5 Responsible for the end-turnover of tRNA specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis (By similarity) VEGS01_19820 ENOG4108UYE Lactoylglutathione lyase VEGS01_19830 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase VEGS01_19840 ENOG4108WUH Transcriptional regulator, TetR family VEGS01_19850 ENOG4107RGM aldo keto reductase VEGS01_19860 ENOG4108Z7T Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) VEGS01_19870 ENOG4105DSW Fusaric acid resistance protein VEGS01_19880 ENOG4105Y49 secretion protein, HlyD family VEGS01_19910 ENOG4108XTF Outer Membrane Lipoprotein VEGS01_19930 ENOG410642K Lysozyme inhibitor VEGS01_19960 ENOG4107XGF functions in a salvage pathway. Uses pyridoxamine (By similarity) VEGS01_19970 ENOG4108K3A Glutathione S-transferase VEGS01_19980 ENOG4105DUX Transporter VEGS01_19990 ENOG4105CSM endonuclease III VEGS01_20010 ENOG4108UQQ Electron transport complex VEGS01_20060 ENOG4105M9B inner membrane protein ydgK VEGS01_20070 ENOG4105QZ5 OriC-binding nucleoid-associated protein VEGS01_20080 ENOG4106C6R beta-lactam resistance protein VEGS01_20090 ENOG4105D9R oxidoreductase VEGS01_20110 ENOG4105C87 Aminotransferase class I and II VEGS01_20120 ENOG4105CI1 PTS System VEGS01_20130 ENOG4107P2S Transcriptional regulator VEGS01_20140 ENOG4107ZQV short-chain dehydrogenase reductase VEGS01_20150 ENOG4105XEA Tetr family transcriptional regulator VEGS01_20160 ENOG4105CNT hydrolase family 2 VEGS01_20170 ENOG4105CT4 transporter VEGS01_20180 ENOG4108QNI outer membrane porin protein VEGS01_20190 ENOG4106J39 exported protein VEGS01_20200 ENOG4105EIP mannose-6-phosphate isomerase VEGS01_20210 ENOG4107GFK fumarate VEGS01_20220 ENOG4105C9Q fumarate hydratase class II VEGS01_20240 ENOG4105JJR Histidine kinase VEGS01_20250 ENOG4107EXC regulatoR VEGS01_20260 ENOG4105RA2 Membrane VEGS01_20280 ENOG4105D5Q Arginine ornithine antiporter VEGS01_20290 ENOG4105C5D exported protein VEGS01_20300 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) VEGS01_20310 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) VEGS01_20320 ENOG4105DSF transport protein VEGS01_20350 ENOG4105CVW peptidase s1 and s6 chymotrypsin hap VEGS01_20370 ENOG4105D94 Major Facilitator Superfamily VEGS01_20380 ENOG4106NZI LysR family Transcriptional regulator VEGS01_20390 ENOG4105DAG ROK family VEGS01_20400 ENOG4105EWW Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) VEGS01_20420 ENOG4108NEM leader-binding protein dmsD VEGS01_20430 ENOG4107KGK dmso reductase anchor subunit VEGS01_20440 ENOG4105QAX Iron-sulfur VEGS01_20450 ENOG4105C3J Cysteine desulfurase VEGS01_20460 ENOG4107QY8 reductase VEGS01_20470 ENOG4105KBG Protein of unknown function (DUF1161) VEGS01_20480 ENOG4105D69 UPF0257 lipoprotein ynfC VEGS01_20490 ENOG4108MK9 spermidine N(1)-acetyltransferase VEGS01_20530 ENOG4105CXK mandelate racemase muconate lactonizing VEGS01_20540 ENOG4105CPQ Dehydrogenase VEGS01_20550 ENOG4107R08 Integrase VEGS01_20580 ENOG4106G8A Qin prophage VEGS01_20630 ENOG41087BU transcriptional repressor DicA VEGS01_20680 ENOG4105F9F transposase VEGS01_20730 ENOG4108MXB Protein of unknown function (DUF968) VEGS01_20740 ENOG4105HRS Antitermination protein VEGS01_20760 ENOG4107SEY Conserved Protein VEGS01_20770 ENOG4108MIW Induces the synthesis of acid phosphatase (AppA) and several other polypeptides (such as AppBC) during the deceleration phase of growth. It also acts as a transcriptional repressor for one group of proteins that are synthesized preferentially in exponential growth and for one group synthesized only in the stationary phase. Also involved in the stabilization of the sigma stress factor RpoS during stress conditions VEGS01_20780 ENOG4105QFS Lysis protein S homolog from lambdoid prophage VEGS01_20820 ENOG4108YV9 Protein of unknown function (DUF2514) VEGS01_20830 ENOG4105VEQ Cold shock protein VEGS01_20840 ENOG4106IAW VEGS01_20850 ENOG4106H71 Overexpression increases levels of unsaturated fatty acids and suppresses both the temperature-sensitive fabA6 mutation and cold-sensitive secG null mutation VEGS01_20910 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) VEGS01_21080 ENOG410685N tail fiber protein VEGS01_21090 ENOG4105UZW Tail fiber assembly protein VEGS01_21120 ENOG4105DEI Mannitol dehydrogenase VEGS01_21130 ENOG41061EV selenium-binding protein YdfZ VEGS01_21140 ENOG4107XBN GntR Family Transcriptional Regulator VEGS01_21150 ENOG4105EMU Dehydrogenase VEGS01_21160 ENOG4105DGW oligopeptidase A VEGS01_21170 ENOG4108WTK competence damage-inducible protein VEGS01_21180 ENOG4108YDI single-species biofilm formation on inanimate substrate VEGS01_21190 ENOG4105FSR swimming returnes to normal when residues 206-207 are both mutated to Ala. Overexpression also leads to a reduction in flagellar abundance and a 20-fold increase in c-di- GMP levels in vivo. Required for aminoglycoside-mediated induction of biofilm formation, it also plays a lesser role in biofilm production in response to other classes of translation inhibitors. The c-di-GMP produced by this enzyme up-regulates poly-GlcNAc production as well as the biofilm synthesis protein PgaD, although c-di-GMP is probably not the main inducing principle. Cyclic-di- GMP is a second messenger which controls cell surface-associated traits in bacteria VEGS01_21200 ENOG4105E5W Transporter VEGS01_21210 ENOG4108594 Permease of the drug metabolite transporter VEGS01_21220 ENOG4106DNR multiple antibiotic resistance protein VEGS01_21230 ENOG4108XW0 May be a transcriptional activator of genes involved in the multiple antibiotic resistance (Mar) phenotype. It can also activate genes such as sodA, zwf and micF VEGS01_21240 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes VEGS01_21280 ENOG4105EGI Transcriptional regulator VEGS01_21290 ENOG4105C26 Dehydrogenase VEGS01_21300 ENOG4105CSV Glutaminase VEGS01_21310 ENOG4105M0C cytoplasmic protein VEGS01_21320 ENOG4105BZU Histidine kinase VEGS01_21340 ENOG4105FFC UPF0187 protein VEGS01_21350 ENOG4107R6G Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate (By similarity) VEGS01_21360 ENOG4105K34 Involved in the degradation of phospho-AI-2, thereby terminating induction of the lsr operon and closing the AI-2 signaling cycle. Catalyzes the cleavage of phosphorylated 4,5- dihydroxy-2,3-pentanedione (P-DPD) to 2-phosphoglycolic acid (PG) and another three-carbon compound VEGS01_21400 ENOG41071MT Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane VEGS01_21410 ENOG4105C2J ABC transporter VEGS01_21460 ENOG41061P8 Persistence to inhibition of murein or DNA biosynthesis regulatory protein VEGS01_21470 ENOG4105CAF HipA N-terminal domain protein VEGS01_21490 ENOG4108WDE Fimbrial protein VEGS01_21500 ENOG4106318 fimbrial-like protein YdeR VEGS01_21510 ENOG4106PIH fimbrial-like protein ydeQ VEGS01_21520 ENOG410600T transposase VEGS01_21530 ENOG4106PIH fimbrial-like protein ydeQ VEGS01_21540 ENOG4107QKC Oxidoreductase alpha (molybdopterin) subunit VEGS01_21560 ENOG4105Z68 AraC Family Transcriptional Regulator VEGS01_21570 ENOG4105ENH Sulfatase VEGS01_21580 ENOG4105C4X radical SAM domain protein VEGS01_21590 ENOG4105CQ0 ABC transporter VEGS01_21600 ENOG4105PE1 Receptor VEGS01_21610 ENOG4107RAN Peptidase, M16 VEGS01_21620 ENOG4105CVK Glutamate decarboxylase VEGS01_21630 ENOG4105E5D amino acid VEGS01_21650 ENOG4105F32 YngK protein VEGS01_21660 ENOG4105BZU Histidine kinase VEGS01_21670 ENOG4105BZU Histidine kinase VEGS01_21680 ENOG4108UQS dipeptidase VEGS01_21690 ENOG4105DEF Extracellular solute-binding protein, family 5 VEGS01_21700 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component VEGS01_21710 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component VEGS01_21720 ENOG4105C3U ABC transporter VEGS01_21730 ENOG4107H6U ABC transporter VEGS01_21740 ENOG4108Z9K Osmotically inducible protein VEGS01_21760 ENOG4105TPS biofilm-dependent modulation protein VEGS01_21770 ENOG4107AV5 Although this protein associates with the 30S subunit of the ribosome it is not considered to be a bona fide ribosomal protein VEGS01_21780 ENOG4107R1I NAD-dependent malic enzyme VEGS01_21790 ENOG4105DQ4 alcohol dehydrogenase VEGS01_21800 ENOG41084S7 Plasmid maintenance system antidote protein VEGS01_21810 ENOG4108MG3 formate dehydrogenase VEGS01_21820 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein VEGS01_21840 ENOG4105RPH Inner membrane protein YddG VEGS01_21860 ENOG4108UI3 Leucine Rich repeat VEGS01_21880 ENOG4107QND Nitrite extrusion protein VEGS01_21890 ENOG4105CRU nitrate reductase, alpha subunit VEGS01_21900 ENOG4108IUE nitrate reductase beta subunit VEGS01_21910 ENOG4108NZN Respiratory nitrate reductase 2 delta chain VEGS01_21920 ENOG4105D0D Nitrate reductase 2, gamma subunit VEGS01_21930 ENOG4105JAB phenazine biosynthesis protein, phzf family VEGS01_21940 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase VEGS01_21950 ENOG4108MEJ flavin reductase domain protein VEGS01_21960 ENOG4105KZK Tautomerase pptA VEGS01_21970 ENOG4108MBK is1 orf2 VEGS01_21980 ENOG410600T transposase VEGS01_22000 ENOG4105CNA YD repeat protein VEGS01_22010 ENOG4105CNA YD repeat protein VEGS01_22020 ENOG4105CS6 Rhs element vgr protein VEGS01_22030 ENOG4108N27 Glutathione S-transferase VEGS01_22040 ENOG4105C85 amino acid VEGS01_22050 ENOG4108NS2 receptor VEGS01_22060 ENOG4105CHB tonB-dependent Receptor VEGS01_22070 ENOG4108WYP Transcriptional regulator VEGS01_22080 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein VEGS01_22090 ENOG4108Z7F N-acetyltransferase VEGS01_22100 ENOG4108T9Y Inner membrane protein ydcZ VEGS01_22110 ENOG4105R71 cytoplasmic protein VEGS01_22120 ENOG410654E Membrane VEGS01_22150 ENOG4105NRK Binding-protein-dependent transport systems, inner membrane component VEGS01_22160 ENOG4105D81 ABC transporter, permease VEGS01_22170 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) VEGS01_22180 ENOG4107TYH extracellular solute-binding protein family 1 VEGS01_22190 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family VEGS01_22200 ENOG4105PF0 Antitoxin component of a toxin-antitoxin (TA) module. Functions as an mRNA interferase antitoxin VEGS01_22210 ENOG4105RR0 Protein of unknown function (DUF2554) VEGS01_22220 ENOG4105CFP Peptidase U32 VEGS01_22230 ENOG4108JCI Transcriptional regulator VEGS01_22240 ENOG4105DKK Benzoate VEGS01_22250 ENOG4105D7V transposase VEGS01_22260 ENOG4108KKZ (LipO)protein VEGS01_22270 ENOG41088CC tellurite resistance protein tehB VEGS01_22280 ENOG4108NKP c4-dicarboxylate transporter malic acid transport protein VEGS01_22290 ENOG4107WE3 acetyltransferase YdcK VEGS01_22300 ENOG4108Z9I -acetyltransferase VEGS01_22310 ENOG4105Z2P Protein of unknown function (DUF465) VEGS01_22330 ENOG4105E32 cytoplasmic protein VEGS01_22340 ENOG4105DDW LysR family Transcriptional regulator VEGS01_22350 ENOG4105C8Q Methyl-accepting chemotaxis VEGS01_22360 ENOG4107NK6 Hok/gef family VEGS01_22370 ENOG4105UPP uncharacterized protein ydcA VEGS01_22380 ENOG4105CPW cytochrome b561 VEGS01_22390 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase VEGS01_22400 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase VEGS01_22410 ENOG4105C26 Dehydrogenase VEGS01_22420 ENOG4107DB1 DUF218 domain VEGS01_22430 ENOG4105CQ7 ATP-dependent helicase VEGS01_22450 ENOG41077RS Phosphatase VEGS01_22460 ENOG4105E8V Alpha Beta Hydrolase Fold protein VEGS01_22480 ENOG4107S5I aldo keto reductase VEGS01_22490 ENOG4108Z0R Transferase VEGS01_22500 ENOG4105V9J phenylacetic acid degradation operon negative regulatory protein VEGS01_22510 ENOG4105DZS Phenylacetate-CoA ligase VEGS01_22520 ENOG4105CHU acetyl-coa acetyltransferase VEGS01_22530 ENOG4108ZJI phenylacetic acid degradation protein VEGS01_22540 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase VEGS01_22550 ENOG4108UKI Enoyl-CoA hydratase VEGS01_22560 ENOG4105E39 Enoyl-CoA hydratase VEGS01_22570 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) VEGS01_22580 ENOG4108ZA2 phenylacetate-CoA oxygenase PaaJ subunit VEGS01_22590 ENOG4105D9S phenylacetate-CoA oxygenase PaaI subunit VEGS01_22600 ENOG4105N76 Phenylacetate-CoA oxygenase, subunit VEGS01_22610 ENOG4105CRS phenylacetate-CoA oxygenase PaaG subunit VEGS01_22620 ENOG4105DXM phenylacetic acid degradation protein VEGS01_22630 ENOG4105F11 amine oxidase VEGS01_22640 ENOG4105C26 Dehydrogenase VEGS01_22650 ENOG4108WFR AraC Family Transcriptional Regulator VEGS01_22660 ENOG4105WXT Conserved Protein VEGS01_22670 ENOG410689M (LipO)protein VEGS01_22680 ENOG4107H52 Dicarboxylate transport VEGS01_22690 ENOG4105C5I Dehydrogenase VEGS01_22700 ENOG41090X5 Heat shock protein hslJ VEGS01_22710 ENOG4105IKK cytoplasmic protein VEGS01_22720 ENOG4105D95 Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity) VEGS01_22730 ENOG4105FCK Membrane VEGS01_22740 ENOG4108RW8 Universal stress protein F VEGS01_22750 ENOG4105W3V DNA-binding, transcriptional regulator VEGS01_22760 ENOG4105MN3 Resolvase VEGS01_22770 ENOG4105UZW Tail fiber assembly protein VEGS01_22780 ENOG4108X9F tail fiber protein VEGS01_22940 ENOG4108ES9 ParB domain protein nuclease VEGS01_22950 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) VEGS01_22990 ENOG4105SZK Rz endopeptidase from lambdoid prophage DLP12 VEGS01_23000 ENOG4105KUS lysozyme VEGS01_23010 ENOG4105QFS Lysis protein S homolog from lambdoid prophage VEGS01_23040 ENOG4108Z82 Cell envelope integrity inner membrane protein TolA VEGS01_23060 ENOG4105RWQ Protein of unknown function (DUF1364) VEGS01_23090 ENOG41076J9 exonuclease VIII VEGS01_23100 ENOG4108PNI recT protein VEGS01_23110 ENOG4106YAH restriction alleviation and modification enhancement VEGS01_23120 ENOG41070YT Rac prophage VEGS01_23130 ENOG4107160 Rac prophage VEGS01_23140 ENOG4107R08 Integrase VEGS01_23160 ENOG4105C1J atp-dependent rna helicase VEGS01_23180 ENOG4105BZU Histidine kinase VEGS01_23190 ENOG4108DG9 Smr protein MutS2 VEGS01_23200 ENOG4106KR7 LysR family Transcriptional regulator VEGS01_23210 ENOG4105CH2 amidohydrolase VEGS01_23220 ENOG4107RT5 aminobenzoyl-glutamate utilization protein B VEGS01_23230 ENOG4105CFC Transporter VEGS01_23240 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) VEGS01_23250 ENOG4105DS0 Transcriptional regulator, Crp Fnr family VEGS01_23260 ENOG4105Q9Y Universal stress protein VEGS01_23270 ENOG4105S5I Membrane VEGS01_23280 ENOG4105D64 Mechanosensitive ion channel VEGS01_23290 ENOG4107QSI ABC, transporter VEGS01_23300 ENOG4105EQ2 LysR family Transcriptional regulator VEGS01_23310 ENOG4105ENX hydrolase VEGS01_23330 ENOG4105KXI murein peptide amidase A VEGS01_23340 ENOG4107S8C mandelate racemase muconate lactonizing VEGS01_23350 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) VEGS01_23360 ENOG4108JU8 Transcriptional regulator VEGS01_23410 ENOG4105CM6 amino acid regulated cytosolic protein VEGS01_23420 ENOG4105FKQ transcriptional regulator VEGS01_23430 ENOG4107EFV Outer membrane protein G VEGS01_23440 ENOG4108IJ9 (ABC) transporter VEGS01_23450 ENOG4107URF beta-phospho-glucomutase VEGS01_23460 ENOG4105C71 hydrolase family 65, central catalytic VEGS01_23470 ENOG4105CK5 oxidoreductase VEGS01_23480 ENOG4107TYA transient receptor potential locus VEGS01_23490 ENOG4107RRD Dehydrogenase VEGS01_23500 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component VEGS01_23510 ENOG4105HS6 binding-protein-dependent transport systems inner membrane Component VEGS01_23520 ENOG4105WEM extracellular solute-binding protein VEGS01_23530 ENOG4107QW3 Sucrose phosphorylase VEGS01_23540 ENOG4107QW3 Sucrose phosphorylase VEGS01_23550 ENOG4105K8Z Phage shock protein VEGS01_23560 ENOG4105NNG Peripheral inner membrane phage-shock protein VEGS01_23570 ENOG4105FM1 phage shock protein C VEGS01_23580 ENOG4105YYT phage shock protein B VEGS01_23590 ENOG41087YS Phage shock protein A VEGS01_23600 ENOG4105E51 psp operon transcriptional activator VEGS01_23610 ENOG4108JPW Aminotransferase VEGS01_23620 ENOG4105CJP fad dependent oxidoreductase VEGS01_23630 ENOG4105C26 Dehydrogenase VEGS01_23640 ENOG4107VRI Transcriptional regulator VEGS01_23650 ENOG4108Z86 Glutamine amidotransferase VEGS01_23660 ENOG4105CFQ glutamine synthetase VEGS01_23670 ENOG4105CUB amino acid VEGS01_23680 ENOG4105N0E Protein of unknown function (DUF2543) VEGS01_23690 ENOG4108HIY periplasmic VEGS01_23700 ENOG4108I5W peptide transport system, permease protein VEGS01_23710 ENOG4108EU3 peptide transport system, permease VEGS01_23720 ENOG4108JQ3 Peptide ABC transporter ATP-binding protein VEGS01_23730 ENOG4108JQ2 peptide transport system atp-binding protein VEGS01_23750 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH VEGS01_23760 ENOG4105Q4T oxidoreductase VEGS01_23780 ENOG4105BZU Histidine kinase VEGS01_23790 ENOG410643D UPF0509 protein VEGS01_23800 ENOG4105N2W Transcriptional regulator VEGS01_23820 ENOG4108ZJT translation initiation factor, Sui1 VEGS01_23830 ENOG4106EG9 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) VEGS01_23840 ENOG4105CFV Tetratricopeptide repeat protein VEGS01_23850 ENOG4105Q4A inner membrane protein yciS VEGS01_23860 ENOG4105EYK Phosphatidylglycerophosphatase B VEGS01_23880 ENOG4107QM5 aconitate hydratase VEGS01_23910 ENOG4107R11 Transcriptional regulator VEGS01_23920 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) VEGS01_23930 ENOG4105RKX Protein of unknown function (DUF2498) VEGS01_23940 ENOG4105ERU peptidase VEGS01_23950 ENOG4105UBK short-chain dehydrogenase reductase VEGS01_23960 ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase VEGS01_23970 ENOG4105FE9 pseudouridine synthase VEGS01_23980 ENOG4105EG3 transmembrane signal peptide protein VEGS01_23990 ENOG4107RTD sua5 ycio yrdc ywlc family protein VEGS01_24000 ENOG4105DB7 PHP domain protein VEGS01_24010 ENOG4105CRQ synthase (Component I) VEGS01_24020 ENOG4108EFP Anthranilate synthase component II VEGS01_24030 ENOG4105DK0 Indole-3-glycerol phosphate synthase VEGS01_24070 ENOG4108Z9Z response to DNA damage stimulus VEGS01_24080 ENOG4108N8X transition metal ion binding VEGS01_24090 ENOG4105EIF outer membrane protein W VEGS01_24120 ENOG4105NAU thioesterase Superfamily protein VEGS01_24130 ENOG410822N TonB family VEGS01_24240 ENOG4105K9H YciI-like protein VEGS01_24250 ENOG4107SVH Potassium channel protein VEGS01_24280 ENOG4108JQ7 (ABC) transporter VEGS01_24290 ENOG4105C3U ABC transporter VEGS01_24300 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component VEGS01_24310 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component VEGS01_24320 ENOG4108J59 Extracellular solute-binding protein, family 5 VEGS01_24340 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein VEGS01_24350 ENOG4105C0A alcohol dehydrogenase VEGS01_24390 ENOG4107104 thymidine kinase VEGS01_24400 ENOG4108SAU DNA-binding protein H-ns VEGS01_24410 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase VEGS01_24420 ENOG4105I93 response regulator VEGS01_24430 ENOG4105D78 K07001 NTE family protein VEGS01_24440 ENOG4105DFP Integrase VEGS01_24530 ENOG4105D5G Transposase VEGS01_24580 ENOG4105K5B UPF0225 protein VEGS01_24590 ENOG4105CIY formyltetrahydrofolate deformylase VEGS01_24600 ENOG41076YT nitrate reductase, gamma subunit VEGS01_24610 ENOG4105R3A Nitrate reductase VEGS01_24620 ENOG4108IUE nitrate reductase beta subunit VEGS01_24630 ENOG4105CRU nitrate reductase, alpha subunit VEGS01_24640 ENOG4105DQQ Major facilitator superfamily MFS_1 VEGS01_24660 ENOG4105BZU Histidine kinase VEGS01_24670 ENOG4105WH1 Two component transcriptional regulator luxr family VEGS01_24680 ENOG4105ID0 Putative invasin VEGS01_24690 ENOG41090EX DsrE family VEGS01_24700 ENOG4108NH8 Cation transport protein VEGS01_24710 ENOG4105WS7 Cation transport regulator VEGS01_24720 ENOG4105EWV Sodium calcium exchanger membrane region VEGS01_24760 ENOG41063JG Transcriptional regulator VEGS01_24770 ENOG4108YY7 Invasion gene expression up-regulator SirB VEGS01_24780 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) VEGS01_24830 ENOG4105C5T Phosphoribosyl pyrophosphate synthase VEGS01_24840 ENOG4105CHH sulfate transporter VEGS01_24850 ENOG4105MGX transcription activated by CRP (cyclic AMP receptor protein), a global transcription factor involved in regulation of metabolism in enteric bacteria VEGS01_24870 ENOG4105C3G gtp-binding protein VEGS01_24880 ENOG4105I1J Autotransporter VEGS01_24890 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family VEGS01_24900 ENOG4105CMT Dihydroxyacetone kinase VEGS01_24910 ENOG4108UTZ Dihydroxyacetone kinase VEGS01_24920 ENOG4105VDH Dihydroxyacetone kinase VEGS01_24970 ENOG4108T7K Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Increasing levels of c-di-GMP lead to decreased motility (By similarity) VEGS01_24980 ENOG4106S48 Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and or cell division VEGS01_25000 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A VEGS01_25020 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) VEGS01_25040 ENOG4105ED1 spovr family VEGS01_25070 ENOG410635M Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein (By similarity) VEGS01_25080 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) VEGS01_25090 ENOG4105KT5 UmuD protein VEGS01_25100 ENOG4106PXS Toxin, which has some hemolytic activity towards mammalian cells. Acts by forming a pore-like structure upon contact with mammalian cells VEGS01_25110 ENOG4106PXS Toxin, which has some hemolytic activity towards mammalian cells. Acts by forming a pore-like structure upon contact with mammalian cells VEGS01_25120 ENOG4106PXS Toxin, which has some hemolytic activity towards mammalian cells. Acts by forming a pore-like structure upon contact with mammalian cells VEGS01_25140 ENOG4105FBJ fumarylacetoacetate (faa) hydrolase VEGS01_25160 ENOG41066UD Inhibits activity of g-type lysozyme, which confers increased lysozyme tolerance to the bacterium VEGS01_25170 ENOG4105S66 prophage protein VEGS01_25190 ENOG4107QMS site-determining protein VEGS01_25240 ENOG410658X VEGS01_25270 ENOG4105BZU Histidine kinase VEGS01_25280 ENOG410738I uncharacterized protein ymgC VEGS01_25300 ENOG41077SS Probably a connector protein for RcsB C regulation of biofilm formation, providing additional signal input into the two- component signaling pathway. May serve to stimulate biofilm maturation, probably via the Rcs phosphorelay. Mild overexpression at 16 degrees Celsius increases the production of colanic acid, an exopolysaccharide and matrix component, and reduces adhesive curli fimbriae expression. Both of these effects require RcsB VEGS01_25310 ENOG4105WKE Probably a connector protein for RcsB C regulation of biofilm formation, providing additional signal input into the two- component signaling pathway. Partially antagonizes the activities of YmgA and AriR, proteins that, via the Rcs phosphorelay, promote the synthesis of colanic acid, an exopolysaccharide and matrix component VEGS01_25320 ENOG4105BZU Histidine kinase VEGS01_25340 ENOG4108XDN Transcriptional regulator VEGS01_25350 ENOG41064WM Uncharacterized protein YcgX VEGS01_25370 ENOG4108HMX isocitrate dehydrogenase (NADP) VEGS01_25380 ENOG4108R99 pseudouridine synthase VEGS01_25420 ENOG4107QTF adenylosuccinate lyase VEGS01_25430 ENOG4105XJC Two component transcriptional regulator (Winged helix family VEGS01_25440 ENOG4105IFJ Histidine kinase VEGS01_25450 ENOG4105EZE Cupin 4 family protein VEGS01_25500 ENOG4105D38 putrescine abc transporter VEGS01_25510 ENOG4107RUE extracellular solute-binding protein family 1 VEGS01_25540 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) VEGS01_25560 ENOG4105D60 lipoprotein releasing system transmembrane protein VEGS01_25570 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) VEGS01_25580 ENOG4105D60 lipoprotein releasing system transmembrane protein VEGS01_25590 ENOG4105IQC Inner membrane protein YcfT VEGS01_25600 ENOG4108JA2 transcriptioN-repair coupling factor VEGS01_25610 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein VEGS01_25620 ENOG4105RC8 Reduces the permeability of the outer membrane to copper. Seems to be involved in the regulation of biofilm formation. May decrease biofilm formation by repressing cell-cell interaction and cell surface interaction VEGS01_25630 ENOG4108IND Tetr family transcriptional regulator VEGS01_25640 ENOG4107MBR 17 kDa surface antigen VEGS01_25650 ENOG4105CEP NADH dehydrogenase VEGS01_25670 ENOG4107QPA Cleaves GlcNAc linked beta-1,4 to MurNAc tripeptides (By similarity) VEGS01_25680 ENOG4108RUM thiamine kinase VEGS01_25690 ENOG4108WEF Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b) (By similarity) VEGS01_25700 ENOG41090DQ Lipoprotein VEGS01_25710 ENOG4105K59 histidine triad (HIT) protein VEGS01_25720 ENOG4105CNM Receptor VEGS01_25730 ENOG4105CI1 PTS System VEGS01_25740 ENOG4105F8V Hydrolase, tatD family VEGS01_25750 ENOG4107QRG dna polymerase iii VEGS01_25770 ENOG4105HHA aminodeoxychorismate lyase VEGS01_25780 ENOG4105YAZ 4-amino-4-deoxychorismate lyase VEGS01_25790 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) VEGS01_25800 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) VEGS01_25810 ENOG4105CHR reductase VEGS01_25820 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase VEGS01_25860 ENOG4105FCQ metal-binding, possibly nucleic acid-binding protein VEGS01_25870 ENOG4108UHJ MAF-like protein VEGS01_25880 ENOG4105EI2 Pseudouridine synthase VEGS01_25890 ENOG4107QQB Ribonuclease E VEGS01_25900 ENOG4105DTJ flagellar hook-associated protein VEGS01_25910 ENOG4105E1Q flagellar hook-associated protein VEGS01_25920 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj VEGS01_25950 ENOG4105CGA flagellar basal-body rod protein FlgG VEGS01_25960 ENOG4108KPB Flagellar basal-body rod protein FlgF VEGS01_25970 ENOG4105BZE flagellar hook protein, FlgE VEGS01_25980 ENOG4105W00 Flagellar hook capping protein VEGS01_26000 ENOG4105W00 Flagellar hook capping protein VEGS01_26010 ENOG4108ZC9 flagellar basal-body rod protein flgc VEGS01_26020 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) VEGS01_26030 ENOG4105CKS Flagella basal body P-ring formation protein flgA VEGS01_26040 ENOG4105M9M anti-sigma28 factor FlgM VEGS01_26050 ENOG4105QVD Flagella synthesis protein FlgN VEGS01_26060 ENOG4105CJR Integral membrane protein (MviN VEGS01_26070 ENOG4105EP9 oxidoreductase VEGS01_26080 ENOG4108YXG UPF0502 protein VEGS01_26090 ENOG4105D9U N-acetyltransferase VEGS01_26110 ENOG4105E9S glutaredoxin 2 VEGS01_26120 ENOG4105F3T (LipO)protein VEGS01_26130 ENOG4105EKE dihydroorotase VEGS01_26140 ENOG4105MEA DNA damage-inducible protein i VEGS01_26150 ENOG4105PVA Biofilm formation regulatory protein BssS VEGS01_26160 ENOG4105F76 Sarcosine oxidase VEGS01_26170 ENOG4105DS1 cytochrome b561 VEGS01_26180 ENOG4108YYC ycei family VEGS01_26190 ENOG4105C72 UPF0176 protein VEGS01_26200 ENOG4105D1S lipid A biosynthesis VEGS01_26220 ENOG4108W47 Acidic protein msyB VEGS01_26230 ENOG4105NAC (LipO)protein VEGS01_26240 ENOG4105C3A Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs) (By similarity) VEGS01_26270 ENOG4107RZC phospholipase d VEGS01_26280 ENOG4108UVJ appr-1-p processing domain protein VEGS01_26300 ENOG4105RK8 Plays a role in the extracellular assembly of CsgA into thin aggregative fimbriae (Tafi) fibers. Assembly may also require CsgE. Tafi are thought to be assembled via an extracellular nucleation-precipitation (ENP) pathway, and possibly also via an intracellular non-CsgC-dependent pathway (By similarity) VEGS01_26310 ENOG4105G76 Curli are coiled surface structures that assemble preferentially at growth temperatures below 37 degrees Celsius. Curli can bind to fibronectin VEGS01_26320 ENOG4108U0V Curli are coiled surface structures that assemble preferentially at growth temperatures below 37 degrees Celsius. Curli can bind to fibronectin. The minor subunit is the nucleation component of curlin monomers VEGS01_26330 ENOG41086KC Transcriptional regulator VEGS01_26340 ENOG4108XDW curli assembly protein CsgE VEGS01_26350 ENOG4108WYR Curli production assembly transport component, CsgF VEGS01_26360 ENOG4105P8Q Curli production assembly transport component CsgG VEGS01_26370 ENOG4108UQ5 membrane protein YcdZ VEGS01_26380 ENOG4107XHZ cytoplasmic chaperone TorD family protein VEGS01_26420 ENOG4105D5M phosphate starvation-inducible protein VEGS01_26430 ENOG4105DBE peroxidase VEGS01_26440 ENOG410650H (LipO)protein VEGS01_26460 ENOG4105CK7 Sodium proline symporter VEGS01_26480 ENOG4105C26 Dehydrogenase VEGS01_26490 ENOG4108R86 Transcriptional regulator VEGS01_26560 ENOG4105C2W permease VEGS01_26570 ENOG4105XF5 Escherichia coli IMT2125 genomic chromosome, IMT2125 VEGS01_26590 ENOG4105XH3 VEGS01_26600 ENOG4105D6F Phosphatase VEGS01_26680 ENOG4108SBI Involved in the biogenesis of TorA. Acts on TorA before the insertion of the molybdenum cofactor and, as a result, probably favors a conformation of the apoenzyme that is competent for acquiring the cofactor (By similarity) VEGS01_26690 ENOG4107QY8 reductase VEGS01_26700 ENOG4105CUW cytochrome C-TYPE protein VEGS01_26710 ENOG4106WF9 DNA-binding transcriptional regulator TorR VEGS01_26720 ENOG4108SV3 Tmao reductase system periplasmic protein tort VEGS01_26730 ENOG4105BZU Histidine kinase VEGS01_26740 ENOG4105HEE Binding Domain protein VEGS01_26750 ENOG4106H71 Overexpression increases levels of unsaturated fatty acids and suppresses both the temperature-sensitive fabA6 mutation and cold-sensitive secG null mutation VEGS01_26760 ENOG4105VEQ Cold shock protein VEGS01_26770 ENOG41060EU Cold shock-like protein VEGS01_26790 ENOG4108Y9B (LipO)protein VEGS01_26800 ENOG4108W78 Pfam:DUF1017 VEGS01_26810 ENOG4105E3R (LipO)protein VEGS01_26830 ENOG4105DAY polysaccharide export protein VEGS01_26840 ENOG4107ZF2 Phosphatase VEGS01_26850 ENOG4108F2G Chain length determinant protein VEGS01_26860 ENOG4105D6F Phosphatase VEGS01_26870 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii VEGS01_26880 ENOG4105C4M (Ubiquinol oxidase) subunit I VEGS01_26890 ENOG4105MVP hydrogenase-1 operon protein HyaF VEGS01_26900 ENOG4108VXY Hydrogenase-1 operon protein HyaE VEGS01_26910 ENOG4108USZ hydrogenase VEGS01_26920 ENOG4105X7T Ni Fe-hydrogenase, b-type cytochrome subunit VEGS01_26930 ENOG4105DPX Hydrogenase, large subunit VEGS01_26940 ENOG4105E3S small subunit VEGS01_26950 ENOG4108MN8 Membrane VEGS01_26960 ENOG4108Z0T Part of a sulfur-relay system (By similarity) VEGS01_26970 ENOG4105VSY K01512 acylphosphatase EC 3.6.1.7 VEGS01_27000 ENOG4105K4P CoA-binding domain protein VEGS01_27030 ENOG41088T4 Helicase IV VEGS01_27040 ENOG410901E Membrane VEGS01_27050 ENOG4105EM2 membrane VEGS01_27060 ENOG4108RZ1 DNA transformation protein VEGS01_27090 ENOG4105UYK outer membrane protein a VEGS01_27100 ENOG4105F9F transposase VEGS01_27120 ENOG4105DAN ATP-dependent protease VEGS01_27140 ENOG4105WFT During stationary phase, converts 70S ribosomes to an inactive dimeric form (100S ribosomes) (By similarity) VEGS01_27150 ENOG4108Q2G (LipO)protein VEGS01_27160 ENOG4105DY2 Paraquat-inducible protein b VEGS01_27170 ENOG4105F1S paraquat-inducible protein a VEGS01_27180 ENOG4105C5H ABC transporter VEGS01_27200 ENOG4105QVC MOSC domain-containing protein VEGS01_27210 ENOG4108T7E Contributes to the efficiency of the cell division process by stabilizing the polymeric form of the cell division protein FtsZ. Acts by promoting interactions between FtsZ protofilaments and suppressing the GTPase activity of FtsZ (By similarity) VEGS01_27240 ENOG4106PH7 chaperone VEGS01_27250 ENOG4105MX3 Fimbrial VEGS01_27260 ENOG4105Q7J Fimbrial VEGS01_27270 ENOG4108MDY Fimbrial VEGS01_27280 ENOG4105CW0 outer membrane usher protein VEGS01_27290 ENOG4106JJN Part of the elfADCG-ycbUVF fimbrial operon, which promotes adhesion of bacteria to different abiotic surfaces. Could be required for the biogenesis of the ElfA fimbriae VEGS01_27300 ENOG41071VI Part of the elfADCG-ycbUVF fimbrial operon, which promotes adhesion of bacteria to different abiotic surfaces. ElfA is the major fimbrial subunit produced by this operon VEGS01_27310 ENOG4108UZX fmn reductase VEGS01_27320 ENOG4105GVF (ABC) transporter VEGS01_27340 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component VEGS01_27350 ENOG4105E2Y ABC, transporter VEGS01_27360 ENOG4105CD8 aminopeptidase N VEGS01_27370 ENOG4107RH7 Nicotinate phosphoribosyltransferase VEGS01_27390 ENOG4105FCK Membrane VEGS01_27410 ENOG4105CGF Aromatic amino acid aminotransferase VEGS01_27420 ENOG4105C5X domain protein VEGS01_27430 ENOG4105EAQ (twin-arginine translocation) pathway signal VEGS01_27440 ENOG4105DIT ErfK YbiS YcfS YnhG family protein VEGS01_27450 ENOG4105DUC Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division (By similarity) VEGS01_27460 ENOG4105DAH Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF (By similarity) VEGS01_27480 ENOG4106371 Methyltransferase VEGS01_27490 ENOG4107S90 membrAne VEGS01_27500 ENOG4107VR7 transferase activity, transferring phosphorus-containing groups VEGS01_27530 ENOG4105T0Z Conserved Protein VEGS01_27540 ENOG4105CHD Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity) VEGS01_27550 ENOG4105BZ1 (ABC) transporter VEGS01_27560 ENOG4108EQH DNA internalization-related competence protein ComEC Rec2 VEGS01_27590 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) VEGS01_27610 ENOG4108K0D peptidase, M48 VEGS01_27630 ENOG4107QM1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) VEGS01_27640 ENOG4107VMU Membrane VEGS01_27650 ENOG4105DDY UPF0142 protein ycaO VEGS01_27660 ENOG4105TMB Formate nitrite transporter VEGS01_27670 ENOG4105C6N Formate acetyltransferase VEGS01_27680 ENOG4105F1A Pyruvate formate-lyase VEGS01_27690 ENOG4108X0B nad(p)h dehydrogenase (quinone) VEGS01_27700 ENOG410642W LysR family Transcriptional regulator VEGS01_27710 ENOG4105E5D amino acid VEGS01_27730 ENOG4105CHJ isochorismatase hydrolase VEGS01_27740 ENOG4107KGK dmso reductase anchor subunit VEGS01_27750 ENOG4105QAX Iron-sulfur VEGS01_27760 ENOG4107QY8 reductase VEGS01_27780 ENOG4105D1H recombination factor protein RarA VEGS01_27800 ENOG4105CNU cell division protein FtsK VEGS01_27820 ENOG4105C3M thioredoxin reductase VEGS01_27830 ENOG4108JJ9 ABC, transporter VEGS01_27840 ENOG4108JJ8 (ABC) transporter VEGS01_27860 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) VEGS01_27870 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit VEGS01_27890 ENOG4105VEQ Cold shock protein VEGS01_27900 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) VEGS01_27910 ENOG4105DJY efflux transporter, rnd family, mfp subunit VEGS01_27920 ENOG4108MJ5 VirK protein VEGS01_27930 ENOG4105CPB ATP-dependent endonuclease of the OLD family VEGS01_27940 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) VEGS01_27950 ENOG4105DWU Membrane VEGS01_27970 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) VEGS01_27980 ENOG4105C7K acetolactate synthase VEGS01_27990 ENOG4105C5W Aldolase VEGS01_28000 ENOG4105CGD Nad-dependent epimerase dehydratase VEGS01_28010 ENOG4107VBM 3-beta hydroxysteroid dehydrogenase isomerase VEGS01_28020 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase VEGS01_28040 ENOG41064MM (LipO)protein VEGS01_28050 ENOG4105E5Z arginine transporter ATP-binding subunit VEGS01_28060 ENOG4106PMH Extracellular solute-binding protein family 3 VEGS01_28070 ENOG4105GBT ABC transporter VEGS01_28080 ENOG4105DMR ABC, transporter VEGS01_28090 ENOG4106TNF Periplasmic binding protein VEGS01_28100 ENOG4107SFS Catalyzes the formation of 5-methyl-uridine at position 747 (m5U747) in 23S rRNA (By similarity) VEGS01_28110 ENOG4105RBQ inner membrane protein ybjO VEGS01_28120 ENOG4105D38 putrescine abc transporter VEGS01_28130 ENOG4105F38 ABC transporter, permease VEGS01_28140 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) VEGS01_28150 ENOG4107RUE extracellular solute-binding protein family 1 VEGS01_28160 ENOG4108RMJ sensory transduction regulator VEGS01_28180 ENOG4108DBC nitroreductase VEGS01_28190 ENOG4105X20 member of the soxRS regulon which mediates in part the increased levels of superoxide in response to oxidative stress VEGS01_28200 ENOG41090BQ Glutaredoxin VEGS01_28220 ENOG4108RFG Tetr family transcriptional regulator VEGS01_28230 ENOG4106UW1 Major Facilitator superfamily VEGS01_28240 ENOG4108HCJ Hydrolase VEGS01_28260 ENOG4107QF7 multi-drug VEGS01_28270 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase VEGS01_28280 ENOG4107FB0 transcriptional regulator DeoR family VEGS01_28290 ENOG4105DZ1 carboxypeptidase VEGS01_28300 ENOG4108TGY Glutathione S-transferase VEGS01_28310 ENOG4105D8V Glucose sorbosone dehydrogenase VEGS01_28320 ENOG4105UFT Represses biofilm formation in M9C glu and LB glu media but not in M9C and LB media. Seems to act as a global regulator of several genes involved in catabolite repression and stress response and regulation of the uptake and export of signaling pathways. Could be involved the regulation of indole as well as uptake and export of AI-2 through a cAMP-dependent pathway VEGS01_28340 ENOG41064RH membrane protein YliF VEGS01_28350 ENOG4105F9F transposase VEGS01_28360 ENOG41064RH membrane protein YliF VEGS01_28370 ENOG4105BZU Histidine kinase VEGS01_28380 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component VEGS01_28400 ENOG4105DEF Extracellular solute-binding protein, family 5 VEGS01_28420 ENOG4105D44 asparaginase VEGS01_28430 ENOG4105CVM Molybdenum cofactor synthesis domain protein VEGS01_28440 ENOG4105D06 uba thif-type nad fad binding protein VEGS01_28450 ENOG4107T9Z Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) VEGS01_28460 ENOG4105F1A Pyruvate formate-lyase VEGS01_28480 ENOG4108HCJ Hydrolase VEGS01_28490 ENOG41072TH Protein of unknown function (DUF1479) VEGS01_28500 ENOG4105C5H ABC transporter VEGS01_28510 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein VEGS01_28520 ENOG4105F4P )-transporter VEGS01_28530 ENOG4105KST dependent repressor VEGS01_28540 ENOG4108I6E Sulfatase VEGS01_28550 ENOG4108T1M outer membrane protein x VEGS01_28560 ENOG4107AQZ Membrane VEGS01_28580 ENOG4107R0W ABC transporter VEGS01_28590 ENOG4105E5Q amino acid AbC transporter VEGS01_28600 ENOG4105CDA abc transporter atp-binding protein VEGS01_28610 ENOG4105D8X mechanosensitive ion channel VEGS01_28630 ENOG4105ZY9 UPF0379 protein ybiM VEGS01_28650 ENOG4108IU3 tonb-dependent siderophore receptor VEGS01_28670 ENOG4105KSC Transcriptional regulator, TraR DksA family VEGS01_28680 ENOG4105VR4 UPF0379 protein ybiJ VEGS01_28690 ENOG4105DG4 malate L-lactate dehydrogenase VEGS01_28700 ENOG4108MTB glycosyl transferase family VEGS01_28710 ENOG4105DVT helicase VEGS01_28720 ENOG4108UV1 cellular component movement VEGS01_28730 ENOG4105C1J atp-dependent rna helicase VEGS01_28740 ENOG4107MVR Transcriptional regulator VEGS01_28760 ENOG4105CJ1 ABC, transporter VEGS01_28770 ENOG4107QWP ABC-2 type transporter VEGS01_28780 ENOG4107QWP ABC-2 type transporter VEGS01_28790 ENOG4105I9U inner membrane protein ybhQ VEGS01_28800 ENOG4105X23 Endonuclease Exonuclease phosphatase VEGS01_28810 ENOG4105DZQ phospholipase D Transphosphatidylase VEGS01_28820 ENOG4107UXM Membrane VEGS01_28830 ENOG410733J conserved inner membrane protein VEGS01_28840 ENOG4105HFZ Membrane VEGS01_28850 ENOG4108ZAF Molybdopterin VEGS01_28860 ENOG4105M00 molybdopterin converting factor, subunit 1 VEGS01_28880 ENOG4108RIR Molybdenum cofactor biosynthesis protein VEGS01_28900 ENOG4105CHW UPF0052 protein VEGS01_28920 ENOG4105E78 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) VEGS01_28930 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) VEGS01_28960 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) VEGS01_28970 ENOG4108V1U phospholipid-binding protein VEGS01_28980 ENOG4105NBR Pectinesterase VEGS01_28990 ENOG4107QM5 aconitate hydratase VEGS01_29000 ENOG4107QPK )-transporter VEGS01_29010 ENOG4105C7F AcnD-accessory protein PrpF VEGS01_29020 ENOG4105F04 LysR family Transcriptional regulator VEGS01_29040 ENOG4108K4B hydrolase VEGS01_29050 ENOG4105CGB Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system (By similarity) VEGS01_29060 ENOG4105E0C molybdate abc transporter VEGS01_29070 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein VEGS01_29090 ENOG4105F4R Transcriptional regulator mode VEGS01_29100 ENOG4105DKW ABC transporter VEGS01_29110 ENOG4105CMR udp-glucose 4-epimerase VEGS01_29120 ENOG4105F0Z galactose-1-phosphate uridylyltransferase VEGS01_29140 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) VEGS01_29160 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) VEGS01_29170 ENOG4105JND homeobox protein VEGS01_29180 ENOG4105PGM cation diffusion facilitator family transporter VEGS01_29190 ENOG4106Z1T Nicotinamide Mononucleotide Transporter VEGS01_29200 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) VEGS01_29210 ENOG4105UFD tol-pal system protein YbgF VEGS01_29220 ENOG4105KCK Peptidoglycan-associated lipoprotein VEGS01_29240 ENOG4108Z82 Cell envelope integrity inner membrane protein TolA VEGS01_29260 ENOG4105E02 MotA TolQ exbB proton channel VEGS01_29270 ENOG4107YD3 Thioesterase VEGS01_29280 ENOG4105KJB cyd operon protein YbgE VEGS01_29290 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii VEGS01_29300 ENOG4105C4M (Ubiquinol oxidase) subunit I VEGS01_29310 ENOG410600T transposase VEGS01_29330 ENOG4105C8I hydrolase, family 38 VEGS01_29340 ENOG4105DM4 PTS System VEGS01_29350 ENOG4105FDP GntR family transcriptional regulator VEGS01_29360 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha VEGS01_29380 ENOG4105C7S Dehydrogenase VEGS01_29390 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 VEGS01_29400 ENOG4105E33 succinate dehydrogenase VEGS01_29410 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) VEGS01_29420 ENOG4105N1I succinate dehydrogenase, hydrophobic membrane anchor protein VEGS01_29430 ENOG4108UTY succinate dehydrogenase, cytochrome b556 subunit VEGS01_29440 ENOG4105BZN citrate synthase VEGS01_29460 ENOG4106UBK fimbrial-like adhesin protein VEGS01_29470 ENOG4106PG1 outer membrane usher protein VEGS01_29480 ENOG4108TTM chaperone VEGS01_29490 ENOG4108MY7 Fimbrial VEGS01_29500 ENOG4108KK1 membrane protein AbrB duplication VEGS01_29530 ENOG4107R7A Allophanate hydrolase subunit 2 VEGS01_29540 ENOG4105P4J Allophanate hydrolase, subunit 1 VEGS01_29550 ENOG4107QNR UPF0135 protein VEGS01_29560 ENOG4105DUX Transporter VEGS01_29570 ENOG4105CVP deoxyribo-dipyrimidine photolyase VEGS01_29580 ENOG4107SEY Conserved Protein VEGS01_29590 ENOG410600T transposase VEGS01_29600 ENOG410600T transposase VEGS01_29610 ENOG410600T transposase VEGS01_29620 ENOG410600T transposase VEGS01_29630 ENOG4106R09 VEGS01_29640 ENOG4105CNA YD repeat protein VEGS01_29650 ENOG41079JQ Membrane VEGS01_29660 ENOG4105CNA YD repeat protein VEGS01_29670 ENOG4105XIQ Protein of unknown function (DUF2517) VEGS01_29690 ENOG4105C8X One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) VEGS01_29700 ENOG4108R80 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity) VEGS01_29710 ENOG4105C08 Histidine kinase VEGS01_29720 ENOG4108MBK is1 orf2 VEGS01_29740 ENOG4107QIX Phosphoglucomutase (EC 5.4.2.2 VEGS01_29750 ENOG4107CDU Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated (By similarity) VEGS01_29760 ENOG4105EV9 Alpha Beta Hydrolase VEGS01_29770 ENOG4105NNH LexA regulated protein VEGS01_29780 ENOG4105MHQ Low-potential electron donor to a number of redox enzymes (By similarity) VEGS01_29790 ENOG41090R7 Ferric uptake VEGS01_29800 ENOG4105GX6 (LipO)protein VEGS01_29830 ENOG4105CI1 PTS System VEGS01_29850 ENOG4105CE4 GlcNAc 6-P deacetylase VEGS01_29860 ENOG4105E2R ROK family VEGS01_29870 ENOG4105D4U had-superfamily hydrolase, subfamily iia VEGS01_29880 ENOG4105CAQ asparagine synthetase VEGS01_29890 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family VEGS01_29910 ENOG4105C9A Phoh family VEGS01_29930 ENOG4108JU5 Magnesium and cobalt efflux protein VEGS01_29940 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) VEGS01_29950 ENOG4107RP9 extracellular solute-binding protein, family 3 VEGS01_29960 ENOG4105EAD ABC transporter VEGS01_29970 ENOG4105DRP amino acid AbC transporter VEGS01_29980 ENOG4105CDA abc transporter atp-binding protein VEGS01_30000 ENOG4108MBK is1 orf2 VEGS01_30010 ENOG4105EUU Sel1 domain protein repeat-containing protein VEGS01_30020 ENOG4107PAI alpha helical protein VEGS01_30050 ENOG4105DJF DNA polymerase III, delta' subunit VEGS01_30070 ENOG4108TGR phosphatase VEGS01_30080 ENOG4105KEM Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) VEGS01_30100 ENOG4105CJN penicillin-binding protein VEGS01_30110 ENOG4105CNI cell division protein FtsW VEGS01_30120 ENOG4105K6T rare lipoprotein A VEGS01_30140 ENOG4105DZ1 carboxypeptidase VEGS01_30180 ENOG41064T2 transcriptional regulator, lysR family VEGS01_30200 ENOG410607N Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatE shares overlapping functions with TatA (By similarity) VEGS01_30240 ENOG41079UR PagP is required both for biosynthesis of hepta-acylated lipid A species containing palmitate and for resistance to cationic antimicrobial peptides (CAMPs). It catalyzes the transfer of a palmitate chain (16 0) from the sn-1 position of a glycerophospholipid to the free hydroxyl group of the (R)-3- hydroxymyristate chain at position 2 of lipid A (endotoxin) (By similarity) VEGS01_30250 ENOG4105CEE C4-dicarboxylate transporter VEGS01_30260 ENOG4106YYS transcriptional regulatory protein VEGS01_30270 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism VEGS01_30280 ENOG4105DUA (citrate (pro-3S)-lyase ligase VEGS01_30300 ENOG4105CI0 Citrate lyase VEGS01_30310 ENOG4105CHY citrate lyase, alpha VEGS01_30340 ENOG4107QPK )-transporter VEGS01_30350 ENOG4105KTS ribonuclease VEGS01_30360 ENOG4105NXH GreA GreB family elongation factor VEGS01_30370 ENOG4105E2A Dehydrogenase VEGS01_30380 ENOG4108U51 Universal stress protein VEGS01_30390 ENOG4108JU3 Alkyl hydroperoxide reductase VEGS01_30400 ENOG4105D3R alkyl hydroperoxide reductase VEGS01_30410 ENOG4108KHN disulfide isomerase, thiol-disulfide oxidase VEGS01_30420 ENOG4105DQS Transcriptional regulator VEGS01_30430 ENOG4105BZV Phosphoadenosine phosphosulfate reductase VEGS01_30440 ENOG4105GTN ParB Domain Protein Nuclease VEGS01_30450 ENOG4105CHM Aminotransferase VEGS01_30460 ENOG4107SCQ Iron-containing alcohol dehydrogenase VEGS01_30470 ENOG4105VCD cytoplasmic protein VEGS01_30480 ENOG4105D22 carbon starvation protein VEGS01_30490 ENOG4108TZA Required for optimal enterobactin synthesis. Acts as a proofreading enzyme that prevents EntB misacylation by hydrolyzing the thioester bound existing between EntB and wrongly charged molecules (By similarity) VEGS01_30500 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase VEGS01_30510 ENOG4105WQI isochorismatase VEGS01_30520 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase VEGS01_30530 ENOG4105E4F Isochorismate synthase VEGS01_30540 ENOG4105PEC Iron-enterobactin transporter periplasmic binding protein VEGS01_30560 ENOG4105DQ5 transport system permease protein VEGS01_30570 ENOG4105TVJ transport system, permease VEGS01_30580 ENOG4105E0A ABC, transporter VEGS01_30590 ENOG4108QY5 Ferric enterobactin transport protein VEGS01_30600 ENOG4105C0W non-ribosomal peptide synthetase VEGS01_30610 ENOG41085A6 mbth domain-containing protein VEGS01_30620 ENOG4105E93 esterase VEGS01_30630 ENOG4107RNH Outer membrane receptor FepA VEGS01_30640 ENOG4108TSE Transferase VEGS01_30650 ENOG4108SER Transposase VEGS01_30660 ENOG4107635 Hok Gef family protein VEGS01_30670 ENOG4106KXD ATP-dependent carboxylate-amine ligase (By similarity) VEGS01_30680 ENOG4105WQ6 Membrane VEGS01_30690 ENOG4105MSB protein, conserved in bacteria VEGS01_30700 ENOG4108RCM Nitroreductase VEGS01_30710 ENOG4105CUY Mechanosensitive ion channel VEGS01_30720 ENOG4105C85 amino acid VEGS01_30730 ENOG4108IJF Heavy metal efflux pump, CzcA VEGS01_30740 ENOG4105EP1 Efflux transporter rnd family, mfp subunit VEGS01_30750 ENOG410624V efflux system protein VEGS01_30760 ENOG4105ENJ RND efflux system, outer membrane lipoprotein VEGS01_30770 ENOG4105CK6 Two component transcriptional regulator (Winged helix family VEGS01_30780 ENOG4105GR3 Histidine kinase VEGS01_30790 ENOG4105CS6 Rhs element vgr protein VEGS01_30810 ENOG4105CNA YD repeat protein VEGS01_30820 ENOG410600T transposase VEGS01_30830 ENOG410802X bacteriophage n4 adsorption protein b VEGS01_30840 ENOG41090FC Bacteriophage N4 receptor, outer membrane subunit VEGS01_30850 ENOG4105QUW VEGS01_30870 ENOG4108Q9V regulatoR VEGS01_30880 ENOG4108ZI2 Fimbrial protein VEGS01_30890 ENOG4108M66 Involved in regulation of length and mediation of adhesion of SfmA fimbriae (but not necessary for the production of fimbriae). Seems to be mannose binding adhesin (By similarity) VEGS01_30900 ENOG4105CW0 outer membrane usher protein VEGS01_30910 ENOG4108MBK is1 orf2 VEGS01_30930 ENOG4105CW0 outer membrane usher protein VEGS01_30940 ENOG4108AF8 Chaperone VEGS01_30950 ENOG4108WDE Fimbrial protein VEGS01_30960 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) VEGS01_30970 ENOG4105WQ3 Rna-binding protein VEGS01_30980 ENOG4105S2T inner membrane protein YbcI VEGS01_31000 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) VEGS01_31020 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) VEGS01_31030 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit VEGS01_31040 ENOG4105C5B carbamate kinase VEGS01_31050 ENOG4105G5A Protein of unknown function (DUF2877) VEGS01_31060 ENOG4107REC cytoplasmic protein VEGS01_31070 ENOG4107R1Q Membrane protein FdrA VEGS01_31080 ENOG4105DG4 malate L-lactate dehydrogenase VEGS01_31090 ENOG4105CE7 Amidase, hydantoinase carbamoylase family VEGS01_31100 ENOG4105S0E allantoin catabolism protein VEGS01_31110 ENOG4105BZW Glycerate kinase VEGS01_31120 ENOG4105DTE Xanthine uracil vitamin C permease VEGS01_31130 ENOG4105CD3 dihydroorotase VEGS01_31140 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease VEGS01_31150 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase VEGS01_31160 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) VEGS01_31170 ENOG41060W2 glyoxylate carboligase VEGS01_31180 ENOG4108N16 Negative regulator of allantoin and glyoxylate utilization operons. Binds to the gcl promoter and to the allS- allA intergenic region VEGS01_31200 ENOG4107653 Transcriptional regulator VEGS01_31210 ENOG4105CR7 Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA (By similarity) VEGS01_31280 ENOG4108MBK is1 orf2 VEGS01_31300 ENOG4105CNA YD repeat protein VEGS01_31310 ENOG4105CNA YD repeat protein VEGS01_31320 ENOG4105CV6 ABC transporter, permease VEGS01_31330 ENOG4108I0Y (ABC) transporter VEGS01_31340 ENOG4108UJV acyl-CoA thioesterase i VEGS01_31350 ENOG4105E1F short-chain dehydrogenase reductase VEGS01_31360 ENOG4107QR8 Thioredoxin VEGS01_31370 ENOG4105C4B ABC transporter, permease VEGS01_31380 ENOG41083J0 (ABC) transporter VEGS01_31390 ENOG4107QX8 SPFH domain, Band 7 family protein VEGS01_31400 ENOG4105G5H Membrane VEGS01_31410 ENOG4108Z6Z Transcriptional regulator VEGS01_31420 ENOG4107RY6 amino acid VEGS01_31430 ENOG4105CSV Glutaminase VEGS01_31440 ENOG4105C59 p-type ATPase VEGS01_31450 ENOG41081XE plasmid maintenance system antidote protein, xre family VEGS01_31460 ENOG4105MBR gumn family VEGS01_31470 ENOG4108Z66 YbaK ebsC protein VEGS01_31480 ENOG4105CGH 5'-nucleotidase VEGS01_31500 ENOG4105CGH 5'-nucleotidase VEGS01_31510 ENOG4105EU0 Major facilitator Superfamily VEGS01_31520 ENOG4105CKD glutathione-regulated potassium-efflux system protein VEGS01_31530 ENOG4107RE1 Inosine-guanosine kinase VEGS01_31600 ENOG4107QMP dna polymerase iii subunits gamma and tau VEGS01_31620 ENOG4105WD1 Membrane VEGS01_31630 ENOG4108URS primosomal replication protein n'' VEGS01_31640 ENOG4106428 Protein of unknown function (DUF2496) VEGS01_31650 ENOG4105EGS Mechanosensitive ion channel VEGS01_31660 ENOG4107XI7 Tetr family transcriptional regulator VEGS01_31670 ENOG4105C1P efflux transporter, rnd family, mfp subunit VEGS01_31680 ENOG4105BZS acriflavin resistance protein VEGS01_31690 ENOG4108UKR Biofilm formation regulator YbaJ VEGS01_31700 ENOG4105KF5 hemolysin expression-modulating protein VEGS01_31710 ENOG4108UW5 maltose o-acetyltransferase VEGS01_31720 ENOG4105GSJ Inner membrane protein ylaC VEGS01_31730 ENOG41066DG (EAL) domain protein VEGS01_31740 ENOG4105KCV RNA signal recognition particle 4.5S RNA VEGS01_31750 ENOG41080UX Methyltransferase VEGS01_31760 ENOG4108MNP Glycoprotein polysaccharide metabolism VEGS01_31770 ENOG4105C29 acyl-CoA thioesterase VEGS01_31780 ENOG4105BZU Histidine kinase VEGS01_31790 ENOG4108YZA Nitrogen regulatory protein pii VEGS01_31800 ENOG4105BZ1 (ABC) transporter VEGS01_31810 ENOG4105BZ1 (ABC) transporter VEGS01_31820 ENOG4108XM1 transcriptional regulator AsnC family VEGS01_31830 ENOG4108AZI Catalyzes the hydrolysis of 4-amino-2-methyl-5- hydroxymethylpyrimidine pyrophosphate (HMP-PP) to 4-amino-2- methyl-5-hydroxymethylpyrimidine phosphate (HMP-P) (By similarity) VEGS01_31840 ENOG4108NFA extracellular solute-binding protein VEGS01_31850 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) VEGS01_31860 ENOG4108TGP Thioesterase superfamily protein VEGS01_31870 ENOG41083P1 competence protein ComEA helix-hairpin-helix repeat protein VEGS01_31880 ENOG4105EIN peptidylprolyl cis-trans isomerase VEGS01_31890 ENOG4105K70 DNA-binding protein VEGS01_31900 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) VEGS01_31940 ENOG4105M85 Bola protein VEGS01_31950 ENOG4105IEY (LipO)protein VEGS01_31960 ENOG4105EYM Major Facilitator superfamily VEGS01_31970 ENOG4105E2S oxidase) subunit II VEGS01_31980 ENOG4105BZ9 Cytochrome C oxidase, subunit I VEGS01_31990 ENOG4105CCU oxidase (Subunit III) VEGS01_32000 ENOG41090KH cytochrome o ubiquinol oxidase (subunit iv) VEGS01_32020 ENOG4107RDB Major Facilitator VEGS01_32040 ENOG4108JZF Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) VEGS01_32050 ENOG4107S0N DJ-1 family VEGS01_32060 ENOG4105D8I Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity) VEGS01_32080 ENOG4105CTB Polyprenyl synthetase VEGS01_32100 ENOG4105CPC Aldo Keto reductase VEGS01_32110 ENOG4108ZAI phosphatidylglycerophosphatase a VEGS01_32120 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) VEGS01_32140 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) VEGS01_32150 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) VEGS01_32170 ENOG4108KIC (LipO)protein VEGS01_32180 ENOG4105DRB nucleoside-specific channel-forming protein VEGS01_32190 ENOG4105N1F Hnh endonuclease VEGS01_32200 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) VEGS01_32210 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) VEGS01_32220 ENOG4105VIE preprotein translocase, subunit YajC VEGS01_32250 ENOG4108ZYK Acyl carrier protein phosphodiesterase VEGS01_32260 ENOG4107R28 alpha amylase, catalytic region VEGS01_32270 ENOG4105C85 amino acid VEGS01_32280 ENOG4105CWM branched-chain amino acid transport system II carrier protein VEGS01_32290 ENOG4105BZU Histidine kinase VEGS01_32300 ENOG4105CK6 Two component transcriptional regulator (Winged helix family VEGS01_32310 ENOG4107RH8 nuclease SbcCD subunit D VEGS01_32320 ENOG4105EYH Exonuclease VEGS01_32330 ENOG4105F27 Major Facilitator VEGS01_32340 ENOG4105DKQ ROK family VEGS01_32380 ENOG4105HBA AroM protein VEGS01_32390 ENOG4105SS3 VEGS01_32410 ENOG4108UPT UPF0178 protein VEGS01_32420 ENOG4105II7 pyrroline-5-carboxylate reductase VEGS01_32430 ENOG4105BZU Histidine kinase VEGS01_32440 ENOG4105VIF phosphate starvation-inducible protein VEGS01_32450 ENOG4105G6Z alkaline phosphatase VEGS01_32470 ENOG4105CPF Cell wall formation (By similarity) VEGS01_32480 ENOG4105UNH Membrane VEGS01_32490 ENOG4105FR5 inner membrane protein YaiY VEGS01_32500 ENOG4107QS8 (LipO)protein VEGS01_32510 ENOG4108DQG in Escherichia coli SbmA is involved in uptake of microcin J25 VEGS01_32520 ENOG4107R6D beta-lactam binding protein AmpH VEGS01_32530 ENOG4108PNB DNA-binding transcriptional regulator VEGS01_32550 ENOG4105F9F transposase VEGS01_32560 ENOG4108NSE outer membrane autotransporter barrel VEGS01_32570 ENOG4105D52 delta-aminolevulinic acid dehydratase VEGS01_32580 ENOG4105E2B Taurine dioxygenase VEGS01_32590 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component VEGS01_32610 ENOG4106FTQ Taurine ABC transporter, periplasmic VEGS01_32630 ENOG4107W19 lmbE family VEGS01_32640 ENOG4108PBI Polysaccharide metabolism VEGS01_32660 ENOG4105SRB Uncharacterized protein yaiO VEGS01_32690 ENOG4105C4W S-formylglutathione hydrolase VEGS01_32700 ENOG4105IUQ nucleoprotein polynucleotide-associated enzyme VEGS01_32710 ENOG4108SC4 )-transporter VEGS01_32770 ENOG4105E2Q 3-(3-hydroxy-phenyl)propionate hydroxylase VEGS01_32780 ENOG4108K2P TRANSCRIPTIONal VEGS01_32790 ENOG4105ETE Transcriptional regulator (LacI family VEGS01_32800 ENOG4105CNT hydrolase family 2 VEGS01_32810 ENOG4105U0F oligosaccharide H symporter, major facilitator superfamily (MFS) VEGS01_32820 ENOG4108UW5 maltose o-acetyltransferase VEGS01_32830 ENOG4105DJ2 Major Facilitator Superfamily VEGS01_32840 ENOG4108V7B Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide (By similarity) VEGS01_32850 ENOG4107B2H carbonic anhydrase VEGS01_32860 ENOG4105DND Transcriptional regulator VEGS01_32870 ENOG4105DZC cytosine deaminase VEGS01_32880 ENOG4105DQW permease for cytosine purines, uracil, thiamine, allantoin VEGS01_32890 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) VEGS01_32900 ENOG4105DXD 2-methylcitrate dehydratase VEGS01_32910 ENOG4105BZN citrate synthase VEGS01_32920 ENOG4105CR4 methylisocitrate lyase VEGS01_32930 ENOG4108JU7 Transcriptional regulator VEGS01_32940 ENOG4105TDT uncharacterized protein yahO VEGS01_32950 ENOG4105E82 cytochrome subunit of dehydrogenase VEGS01_32980 ENOG4105DQ4 alcohol dehydrogenase VEGS01_32990 ENOG4105DZC cytosine deaminase VEGS01_33000 ENOG4105C5B carbamate kinase VEGS01_33010 ENOG4107REC cytoplasmic protein VEGS01_33020 ENOG4107R1Q Membrane protein FdrA VEGS01_33040 ENOG4108MBK is1 orf2 VEGS01_33050 ENOG4105N16 Protein of unknown function (DUF2877) VEGS01_33060 ENOG4107SNB ankyrin repeat protein YahD VEGS01_33070 ENOG4105SZ2 membrAne VEGS01_33080 ENOG4108NUU Transcriptional regulator VEGS01_33090 ENOG4105BZU Histidine kinase VEGS01_33120 ENOG4108MBK is1 orf2 VEGS01_33130 ENOG4105C94 Transporter VEGS01_33140 ENOG4108MHR Repressor involved in choline regulation of the bet genes (By similarity) VEGS01_33150 ENOG4105C26 Dehydrogenase VEGS01_33160 ENOG4105CZ6 Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine (By similarity) VEGS01_33180 ENOG4108ZZK Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source (By similarity) VEGS01_33190 ENOG4107QR9 Iron-sulfur cluster binding protein VEGS01_33200 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) VEGS01_33210 ENOG4108MBK is1 orf2 VEGS01_33230 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) VEGS01_33240 ENOG4107QK5 Homocysteine s-methyltransferase VEGS01_33250 ENOG4108IQI permease VEGS01_33260 ENOG4108SC4 )-transporter VEGS01_33270 ENOG4108MXD gtp-binding protein VEGS01_33280 ENOG4106H6R UPF0380 protein VEGS01_33290 ENOG4108KZE transcriptional regulator VEGS01_33320 ENOG4106J9S Prophage VEGS01_33330 ENOG4106ZN7 UPF0401 protein YkfF VEGS01_33340 ENOG4106549 Antirestriction protein VEGS01_33350 ENOG4108XS9 dna repair protein VEGS01_33360 ENOG4105ZS6 Protein of unknown function (DUF987) VEGS01_33380 ENOG4108X3P Toxic component of a toxin-antitoxin (TA) module. Overexpression results in inhibition of growth in liquid cultures VEGS01_33640 ENOG4105VDM plasmid maintenance system antidote protein, xre family VEGS01_33680 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) VEGS01_33700 ENOG4105FCK Membrane VEGS01_33720 ENOG4105V1F Fermentation respiration switch protein VEGS01_33740 ENOG4105CIN aminoacyl-histidine dipeptidase VEGS01_33750 ENOG4108S2Y peptide Chain Release factor VEGS01_33770 ENOG4108HYG acetyltransferase VEGS01_33780 ENOG41065DM this blockage is overcome by subsequent expression of antitoxin YafN. Overexpression causes cleavage of a number of mRNAs in a ribosome-dependent fashion. YafO binding to the 50S ribosomal subunit in the translation complex induces mRNA cleavage 3' to the region protected by the ribosome VEGS01_33790 ENOG4105UG9 Antitoxin of the YafO-YafN toxin-antitoxin system VEGS01_33800 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) VEGS01_33830 ENOG4108UK5 Transposase VEGS01_33840 ENOG4108YS0 lipoprotein YafL VEGS01_33870 ENOG4105VXN addiction module toxin, RelE StbE family VEGS01_33880 ENOG4105F7V ErfK ybiS ycfS ynhG family protein VEGS01_33890 ENOG4105E7A Glutamine amidotransferase VEGS01_33910 ENOG4107QPN acyl-Coa dehydrogenase VEGS01_33920 ENOG4108WN0 inhibitor of vertebrate lysozyme VEGS01_33930 ENOG4105CZ7 nitrilase cyanide hydratase and apolipoprotein n-acyltransferase VEGS01_33940 ENOG410600T transposase VEGS01_33970 ENOG4105CNA YD repeat protein VEGS01_33980 ENOG4105CS6 Rhs element vgr protein VEGS01_33990 ENOG4108WC9 type VI secretion system effector, hcp1 family VEGS01_34100 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit VEGS01_34150 ENOG4105GMB type VI secretion system effector, hcp1 family VEGS01_34170 ENOG4108MBK is1 orf2 VEGS01_34190 ENOG4107RZZ dna polymerase iii epsilon subunit VEGS01_34210 ENOG4105D1A Methyltransferase VEGS01_34220 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) VEGS01_34230 ENOG4105E9H Lytic Murein transglycosylase VEGS01_34240 ENOG4105F2W methyltransferase VEGS01_34260 ENOG4105HEI LysR family (Transcriptional regulator VEGS01_34270 ENOG4105CV8 reductase VEGS01_34280 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase VEGS01_34290 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) VEGS01_34300 ENOG4108UMI ABC transporter, permease VEGS01_34310 ENOG4105D01 (LipO)protein VEGS01_34320 ENOG4108R8X outer membrane lipoprotein VEGS01_34330 ENOG4108R96 Methyltransferase, YaeB family VEGS01_34350 ENOG4108UY0 (LipO)protein VEGS01_34360 ENOG4107EII Lipoprotein involved with copper homeostasis and adhesion VEGS01_34370 ENOG4108YZN class I peptide chain release factor VEGS01_34380 ENOG4108VWS Yaeq family VEGS01_34400 ENOG4105M1T rho-binding antiterminator VEGS01_34410 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) VEGS01_34420 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase VEGS01_34430 ENOG4105CXN decarboxylase VEGS01_34450 ENOG4105C0B DNA polymerase III (alpha subunit) VEGS01_34500 ENOG4105D7M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) VEGS01_34510 ENOG4108RFI Molecular chaperone that interacts specifically with outer membrane proteins, thus maintaining the solubility of early folding intermediates during passage through the periplasm (By similarity) VEGS01_34530 ENOG4105DZP Membrane-associated zinc metalloprotease VEGS01_34540 ENOG4105KNE Phosphatidate cytidylyltransferase VEGS01_34550 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) VEGS01_34560 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) VEGS01_34610 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) VEGS01_34620 ENOG4105E1P Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity) VEGS01_34640 ENOG4105DIN metallophosphoesterase VEGS01_34660 ENOG4108IXP Carbohydrate diacid transcriptional activator CdaR VEGS01_34670 ENOG4105C0H protease VEGS01_34700 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) VEGS01_34710 ENOG4105EN6 Membrane VEGS01_34750 ENOG4105S6R Iron-hydroxamate transporter permease subunit VEGS01_34760 ENOG4105J76 Periplasmic binding protein VEGS01_34770 ENOG4105E0A ABC, transporter VEGS01_34780 ENOG4105E0K tonB-dependent siderophore receptor VEGS01_34790 ENOG4105BZ4 penicillin-binding protein VEGS01_34810 ENOG4105CQ7 ATP-dependent helicase VEGS01_34820 ENOG4107XID 2'-5' rna ligase VEGS01_34860 ENOG4105DJ0 Poly(A) Polymerase VEGS01_34870 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase VEGS01_34880 ENOG4108MBK is1 orf2 VEGS01_34900 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) VEGS01_34920 ENOG4108A32 Transposase VEGS01_34940 ENOG4107BJW polysaccharide deacetylase VEGS01_34950 ENOG4108YTN IIa component VEGS01_34960 ENOG4105E3A (ABC) transporter VEGS01_34970 ENOG4105DA5 (ABC) transporter VEGS01_34980 ENOG41077A9 carbonic anhydrase VEGS01_34990 ENOG4108UGV hypoxanthine phosphoribosyltransferase VEGS01_35000 ENOG4105DZG Dehydrogenase VEGS01_35010 ENOG4105E3B Multicopper oxidase VEGS01_35020 ENOG4108ZRK uncharacterized protein yacC VEGS01_35060 ENOG4107QIJ Aconitate hydratase 2 VEGS01_35070 ENOG4108NST exported protein VEGS01_35080 ENOG4107QN2 dihydrolipoyl dehydrogenase VEGS01_35090 ENOG4107QSN dihydrolipoamide acetyltransferase VEGS01_35100 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) VEGS01_35110 ENOG41073TP transcriptional regulator VEGS01_35120 ENOG4105C85 amino acid VEGS01_35130 ENOG4106A72 regulatory protein AmpE VEGS01_35140 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase VEGS01_35150 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase VEGS01_35160 ENOG4108ZUW Major pilin subunit VEGS01_35170 ENOG4107QHF type ii secretion system protein e VEGS01_35180 ENOG4105D7Q type ii secretion system VEGS01_35200 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) VEGS01_35230 ENOG4105M6F mutator MutT protein VEGS01_35250 ENOG4108SR7 Regulates secA expression by translational coupling of the secM secA operon. Translational pausing at a specific Pro residue 5 residues before the end of the protein may allow disruption of a mRNA repressor helix that normally suppresses secA translation initiation (By similarity) VEGS01_35270 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) VEGS01_35280 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) VEGS01_35290 ENOG4105K7E Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity) VEGS01_35300 ENOG4105CPF Cell wall formation (By similarity) VEGS01_35310 ENOG4105DFU Cell wall formation (By similarity) VEGS01_35320 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) VEGS01_35330 ENOG4105CNI cell division protein FtsW VEGS01_35340 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) VEGS01_35360 ENOG4108EQQ Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity) VEGS01_35370 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) VEGS01_35380 ENOG4105CJN penicillin-binding protein VEGS01_35390 ENOG41063Y6 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) VEGS01_35410 ENOG4108V6E Cell division protein mraZ VEGS01_35420 ENOG4107B7Y DNA-binding transcriptional regulator FruR VEGS01_35430 ENOG4108ZP8 Acetolactate synthase small subunit VEGS01_35440 ENOG4105C7K acetolactate synthase VEGS01_35450 ENOG41064T2 transcriptional regulator, lysR family VEGS01_35470 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) VEGS01_35500 ENOG4105S8Q sugar efflux transporter VEGS01_35520 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) VEGS01_35530 ENOG4105DP9 ABC transporter VEGS01_35540 ENOG4106SMU thiamine transporter membrane protein VEGS01_35550 ENOG4107T0D ABC, transporter VEGS01_35560 ENOG4108KF1 Membrane VEGS01_35570 ENOG41063TF transcriptional regulator (AraC VEGS01_35580 ENOG4105EF1 ribulokinase VEGS01_35590 ENOG4105CAC Catalyzes the conversion of L-arabinose to L-ribulose (By similarity) VEGS01_35600 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase VEGS01_35610 ENOG4105CQ2 DNA polymerase VEGS01_35620 ENOG4105BZK Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair (By similarity) VEGS01_35630 ENOG4105D3G Pseudouridine synthase VEGS01_35650 ENOG41066UG Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host (By similarity) VEGS01_35660 ENOG4105E7H involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity) VEGS01_35670 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) VEGS01_35680 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) VEGS01_35710 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) VEGS01_35720 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) VEGS01_35750 ENOG4105C54 Major Facilitator superfamily VEGS01_35760 ENOG4105IBM Could be part of an electron transfer system required for anaerobic carnitine reduction. Could be a 3Fe-4S cluster- containing protein VEGS01_35770 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase VEGS01_35840 ENOG4106YT9 Enoyl-CoA hydratase VEGS01_35860 ENOG4108XNW Transcriptional activatory protein CaiF VEGS01_35880 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain VEGS01_35890 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain VEGS01_35910 ENOG4105DUK Catalyzes the conversion of 4-hydroxy- tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate (By similarity) VEGS01_35940 ENOG41090X3 Peptidyl-prolyl cis-trans isomerase VEGS01_35960 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) VEGS01_35970 ENOG4105DTN riboflavin biosynthesis protein ribF VEGS01_36010 ENOG4105CW0 outer membrane usher protein VEGS01_36030 ENOG41063Z6 transcriptional regulator, lysR family VEGS01_36060 ENOG4108SER Transposase VEGS01_36100 ENOG4108QUJ UPF0174 protein YaaW VEGS01_36110 ENOG4106HK8 GPR1 FUN34 yaaH family protein VEGS01_36120 ENOG4108RIR Molybdenum cofactor biosynthesis protein VEGS01_36140 ENOG4105BZG amino acid carrier protein VEGS01_36170 ENOG4105D98 threonine synthase VEGS01_36190 ENOG4105CFH Aspartokinase VEGS01_36200 ENOG4106FVC RNA methyltransferase VEGS01_36210 ENOG41065U4 response regulator VEGS01_36220 ENOG4105CT7 inner membrane cred family protein VEGS01_36230 ENOG4105EB3 Histidine kinase VEGS01_36240 ENOG4105E3W Two component transcriptional regulator (Winged helix family VEGS01_36250 ENOG4108RH0 Crea protein VEGS01_36260 ENOG4105UEI Transcriptional Regulator AraC Family VEGS01_36280 ENOG4108K16 Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) VEGS01_36300 ENOG4107SC1 transglycosylase VEGS01_36310 ENOG4105C5H ABC transporter VEGS01_36320 ENOG4107VZS Nicotinamide-nucleotide adenylyltransferase VEGS01_36330 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) VEGS01_36340 ENOG4105EAC phosphoserine phosphatase VEGS01_36350 ENOG41062Z9 Membrane VEGS01_36390 ENOG4105D3A purine nucleoside phosphorylase DeoD-type VEGS01_36430 ENOG4105G0K glycine radical enzyme YjjI family VEGS01_36440 ENOG41076CZ activating enzyme VEGS01_36450 ENOG4105EYA deoxyribonuclease VEGS01_36460 ENOG4108NRW Phospholipase, patatin family VEGS01_36480 ENOG4105K3G Periplasmic Protein VEGS01_36500 ENOG4105PAD Hydrolase VEGS01_36510 ENOG4105KEG ribosomal-protein-alanine acetyltransferase VEGS01_36520 ENOG4108WPU DNA polymerase III subunit psi VEGS01_36540 ENOG4105YBH Protein of unknown function (DUF1435) VEGS01_36550 ENOG4108819 ferric iron reductase VEGS01_36560 ENOG4108T94 DNA-binding transcriptional activator BglJ VEGS01_36570 ENOG4108N8T regulatoR VEGS01_36580 ENOG4105DWK Membrane VEGS01_36590 ENOG4107XM3 UPF0442 protein VEGS01_36610 ENOG4106CVF DNA replication protein VEGS01_36620 ENOG4105RI1 glycoprotein receptor VEGS01_36640 ENOG4105CPQ Dehydrogenase VEGS01_36650 ENOG4105F2I Transposase VEGS01_36660 ENOG4108I5G Major Facilitator superfamily VEGS01_36670 ENOG4105C8Q Methyl-accepting chemotaxis VEGS01_36680 ENOG4105D22 carbon starvation protein VEGS01_36690 ENOG4105VCD cytoplasmic protein VEGS01_36700 ENOG4105CKI cobalamin synthesis protein VEGS01_36710 ENOG4106H3A restriction VEGS01_36720 ENOG4108MBK is1 orf2 VEGS01_36740 ENOG4106DIZ Domain of unknown function (DUF1127) VEGS01_36750 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family VEGS01_36760 ENOG4105F9F transposase VEGS01_36770 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family VEGS01_36790 ENOG41083G8 Multidrug resistance protein MdtM VEGS01_36800 ENOG4106BRA Membrane VEGS01_36810 ENOG4105DCU 2-hydroxyglutaryl-CoA dehydratase VEGS01_36820 ENOG4105CIZ coA-substrate-specific enzyme activase VEGS01_36850 ENOG4105CBP Major Facilitator VEGS01_36870 ENOG41074DU domain protein VEGS01_36880 ENOG4108P2H Inner membrane protein YjiG VEGS01_36890 ENOG4105DYB Isoaspartyl dipeptidase VEGS01_36900 ENOG4107YNJ LysR family Transcriptional regulator VEGS01_36970 ENOG4105C6F GntR Family Transcriptional Regulator VEGS01_36980 ENOG4105DEI Mannitol dehydrogenase VEGS01_37000 ENOG4107EFN gluconate transport system permease 3 VEGS01_37010 ENOG410643X FIMH SUBUNIT MANNOSE-sensitive type 1 fimbrial adhesin VEGS01_37020 ENOG4108T65 Fimbrial VEGS01_37030 ENOG4108SQA Fimbrial VEGS01_37040 ENOG4105CW0 outer membrane usher protein VEGS01_37050 ENOG4108NAE Fimbrial chaperone protein VEGS01_37060 ENOG4108S54 Fimbrial protein VEGS01_37070 ENOG4108RQP Major type 1 subunit fimbrin VEGS01_37080 ENOG4105E71 FimE is one of the 2 regulatory proteins which control the phase variation of type 1 fimbriae in E.coli. These proteins mediate the periodic inversion of a 300bp DNA segment that harbors the promoter for the fimbrial structural gene, fimA. FimE switches fimA off VEGS01_37090 ENOG41069FU Outer membrane channel protein allowing the entry of N- acetylneuraminic acid (Neu5Ac, the most abundant sialic acid on host cell surfaces) into the bacteria VEGS01_37120 ENOG4108MBK is1 orf2 VEGS01_37180 ENOG4108YXQ IS66 Orf2 family protein VEGS01_37200 ENOG4105E5H Transposase VEGS01_37220 ENOG4107FB0 transcriptional regulator DeoR family VEGS01_37240 ENOG4105EDR glucose galactose transporter VEGS01_37260 ENOG4108ZQS transposase VEGS01_37290 ENOG4105CZC PTS system ascorbate-specific transporter subunit IIC VEGS01_37310 ENOG4106ETB IIa component VEGS01_37330 ENOG4105EKQ RNA-directed DNA polymerase VEGS01_37370 ENOG4105DJB Major Facilitator Superfamily VEGS01_37380 ENOG4105CBH Hydroxymethylglutaryl-CoA lyase VEGS01_37390 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F VEGS01_37430 ENOG4105EKQ RNA-directed DNA polymerase VEGS01_37480 ENOG4105DQ4 alcohol dehydrogenase VEGS01_37490 ENOG4105D7A ATP-binding protein VEGS01_37500 ENOG4108K5H permease YjgP YjgQ family protein VEGS01_37510 ENOG4108M8S permease YjgP YjgQ family protein VEGS01_37530 ENOG4105MYG DNA polymerase iii, chi subunit VEGS01_37540 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) VEGS01_37550 ENOG4108M3P Membrane VEGS01_37560 ENOG4108MJ3 acetyltransferase VEGS01_37570 ENOG4105KQT Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome (By similarity) VEGS01_37600 ENOG4105XEP YhcH YjgK YiaL family protein VEGS01_37610 ENOG4108XFH Transcriptional regulator VEGS01_37620 ENOG4105F6U Short-chain dehydrogenase reductase Sdr VEGS01_37630 ENOG4108UQ8 endoribonuclease L-psp VEGS01_37660 ENOG4105KME endoribonuclease L-psp VEGS01_37670 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic VEGS01_37680 ENOG4105D4X repressor VEGS01_37690 ENOG4105C5Y PTS System VEGS01_37700 ENOG4105CG3 alpha amylase, catalytic region VEGS01_37710 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase VEGS01_37720 ENOG4108RDD Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine (By similarity) VEGS01_37740 ENOG4105CMS peptidase U62, modulator of DNA gyrase VEGS01_37760 ENOG4105DFU Cell wall formation (By similarity) VEGS01_37780 ENOG41062B0 ABC transporter, permease VEGS01_37790 ENOG4107R9N ABC transporter VEGS01_37800 ENOG4105C2J ABC transporter VEGS01_37810 ENOG4107R5U Periplasmic binding protein LacI transcriptional regulator VEGS01_37820 ENOG4105F0N pyrophosphate phospho-hydrolase VEGS01_37830 ENOG4108ZHD aig2 family VEGS01_37840 ENOG4105MA0 exported protein VEGS01_37850 ENOG4105CFU surface antigen VEGS01_37880 ENOG4105C37 (CBS) domain VEGS01_37890 ENOG41061GZ Protein of unknown function (DUF1107) VEGS01_37900 ENOG4108UUE Transcriptional regulator VEGS01_37910 ENOG4108RNI 3'(2')5'-bisphosphate nucleotidase VEGS01_37920 ENOG4107RNS bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase 3'-nucleotidase periplasmic VEGS01_37930 ENOG4107RNS bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase 3'-nucleotidase periplasmic VEGS01_37940 ENOG4105KVH Transcriptional regulator VEGS01_37950 ENOG4105ECR NmrA family VEGS01_37960 ENOG4105DXC membrane VEGS01_37980 ENOG4105C85 amino acid VEGS01_37990 ENOG4108V1T peptidylprolyl cis-trans isomerase VEGS01_38000 ENOG4105FHY Opacity-associated protein A VEGS01_38020 ENOG4105CHR reductase VEGS01_38040 ENOG4105E39 Enoyl-CoA hydratase VEGS01_38050 ENOG4107R0K CoA transferase having broad substrate specificity for short-chain acyl-CoA thioesters with the activity decreasing when the length of the carboxylic acid chain exceeds four carbons (By similarity) VEGS01_38090 ENOG4105DPW Major facilitator superfamily MFS_1 VEGS01_38110 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) VEGS01_38140 ENOG4105KIT UPF0379 protein yjfY VEGS01_38150 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase VEGS01_38190 ENOG410907W The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in ascorbate transport VEGS01_38200 ENOG4105CZC PTS system ascorbate-specific transporter subunit IIC VEGS01_38230 ENOG4108MXZ Esterase VEGS01_38240 ENOG4105WSB biofilm stress and motility protein A VEGS01_38250 ENOG4105S17 UPF0379 protein yjfN VEGS01_38260 ENOG4105CSU acyl-Coa dehydrogenase VEGS01_38270 ENOG4106032 Glutathionylspermidine synthase VEGS01_38280 ENOG4108KXT Conserved Protein VEGS01_38290 ENOG4105Z6B inner membrane protein yjfl VEGS01_38300 ENOG4107VNS Protein of unknown function (DUF2491) VEGS01_38310 ENOG4108P9J Phage shock protein A VEGS01_38320 ENOG4105FUX Conserved Protein VEGS01_38330 ENOG4105C2N RNA methyltransferase TrmH family group 3 VEGS01_38340 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) VEGS01_38380 ENOG4105EPW hflc protein VEGS01_38390 ENOG4107QJR hflk protein VEGS01_38400 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) VEGS01_38430 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) VEGS01_38440 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase VEGS01_38450 ENOG4105K8N protein family UPF0079, ATPase VEGS01_38460 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) VEGS01_38470 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) VEGS01_38510 ENOG4105EGS Mechanosensitive ion channel VEGS01_38520 ENOG4107SC7 Inner membrane transporter yjeM VEGS01_38540 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) VEGS01_38550 ENOG4105E33 succinate dehydrogenase VEGS01_38580 ENOG41066YJ Beta-lactamase VEGS01_38590 ENOG4105QNF Outer membrane lipoprotein VEGS01_38600 ENOG4105KPY Small multidrug resistance protein VEGS01_38610 ENOG4106BSU Entericidin B VEGS01_38630 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein VEGS01_38640 ENOG4105MTB Uncharacterized protein YjeJ VEGS01_38650 ENOG4108ZVF (LipO)protein VEGS01_38680 ENOG4105DVH amino acid VEGS01_38690 ENOG4108YH1 overproduction of this protein in Escherichia coli inhibits the F plasmid-mediated exclusion of bacteriophage T7 VEGS01_38700 ENOG4108IJ0 Aspartate ammonia-lyase VEGS01_38710 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter VEGS01_38740 ENOG4108SIC Transcriptional regulator VEGS01_38750 ENOG4108M3R transcriptional activator CadC VEGS01_38760 ENOG4105D5Q Arginine ornithine antiporter VEGS01_38770 ENOG4105CXN decarboxylase VEGS01_38780 ENOG4105DUX Transporter VEGS01_38790 ENOG4105CRK lysyL-tRNA synthetase VEGS01_38820 ENOG410830R acetyltransferase VEGS01_38830 ENOG4105VR1 Pfam:DUF1271 VEGS01_38850 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism VEGS01_38860 ENOG4108MRH transcriptional regulatory protein VEGS01_38870 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter VEGS01_38880 ENOG4107GFK fumarate VEGS01_38890 ENOG4108R5S membrane VEGS01_38900 ENOG4105CT4 transporter VEGS01_38910 ENOG4105F8D glycoside hydrolase family 4 VEGS01_38920 ENOG4108K2B transcriptional regulator VEGS01_38930 ENOG4105CXN decarboxylase VEGS01_38940 ENOG4106ZGR Transcriptional regulator VEGS01_38950 ENOG4105D5Q Arginine ornithine antiporter VEGS01_38960 ENOG4105DIJ Phosphoethanolamine transferase VEGS01_38970 ENOG4105XJC Two component transcriptional regulator (Winged helix family VEGS01_38980 ENOG4105ECM Sensor protein basS pmrB VEGS01_38990 ENOG4105CSH Transporter VEGS01_39000 ENOG4108YIV VEGS01_39010 ENOG4108F5E vimentin VEGS01_39020 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA VEGS01_39030 ENOG4108SQ4 Glyoxalase Bleomycin resistance protein (Dioxygenase VEGS01_39040 ENOG4105D5T phosphonate abc transporter VEGS01_39050 ENOG4105EHI Phosphonate ABC transporter, periplasmic VEGS01_39070 ENOG4107RJJ Transcriptional regulator VEGS01_39080 ENOG4105KQZ Phosphonate C-P lyase system protein PhnG VEGS01_39090 ENOG4105KZ6 phosphonate C-P lyase system protein PhnH VEGS01_39100 ENOG4105EKV Phosphonate metabolism protein VEGS01_39110 ENOG4105FT8 Phosphonate metabolism VEGS01_39120 ENOG4105ENV phosphonate C-P lyase system protein PhnK VEGS01_39130 ENOG4105HRV phosphonate c-p lyase system protein phnl VEGS01_39140 ENOG4105FD8 phosphonate metabolism protein PhnM VEGS01_39150 ENOG4105MFQ Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP) (By similarity) VEGS01_39160 ENOG410849A acetyltransferase, (GNAT) family VEGS01_39170 ENOG4107SA6 carbon-phosphorus lyase complex accessory protein VEGS01_39190 ENOG4108YZG isomerase VEGS01_39200 ENOG4105NYY transcriptional regulator, RpiR VEGS01_39210 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator VEGS01_39220 ENOG4105C2J ABC transporter VEGS01_39230 ENOG4105CNN ABC, transporter VEGS01_39240 ENOG4105UP7 3-epimerase VEGS01_39250 ENOG4107TFG D-allose kinase VEGS01_39260 ENOG4105EUZ Beta-lactamase domain protein VEGS01_39270 ENOG4106833 VEGS01_39280 ENOG4105J12 Multidrug resistance protein mdtN VEGS01_39290 ENOG4108MI0 Resistance protein VEGS01_39300 ENOG4105ETP RND efflux system, outer membrane lipoprotein VEGS01_39320 ENOG41082ND Uncharacterized protein yjcO VEGS01_39330 ENOG4105CK2 sodium dicarboxylate symporter VEGS01_39340 ENOG4108W0S formate-dependent nitrite reductase complex VEGS01_39360 ENOG4108QKW cytochrome c-type biogenesis protein VEGS01_39370 ENOG4105DVI reductase, NrfD VEGS01_39380 ENOG4105D3S 4Fe-4S Ferredoxin, iron-sulfur binding domain protein VEGS01_39390 ENOG4105JJ8 Cytochrome c nitrite reductase, pentaheme subunit VEGS01_39410 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) VEGS01_39420 ENOG41062QD Membrane VEGS01_39450 ENOG4105EEQ Na H antiporter VEGS01_39460 ENOG4105C7N Xanthine uracil vitamin C permease VEGS01_39470 ENOG4108Z4X TRANSCRIPTIONal VEGS01_39480 ENOG4108W3Q Transcriptional regulator VEGS01_39490 ENOG4108M8H domain protein VEGS01_39500 ENOG4105PMV Membrane VEGS01_39510 ENOG4108UUM single-stranded DNA-binding protein VEGS01_39520 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) VEGS01_39530 ENOG4105MSB protein, conserved in bacteria VEGS01_39540 ENOG4108YXI Secondary thiamine-phosphate synthase enzyme VEGS01_39550 ENOG4105F0S class B acid phosphatase VEGS01_39580 ENOG4105CGF Aromatic amino acid aminotransferase VEGS01_39590 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) VEGS01_39600 ENOG4105CDU Replicative dna helicase VEGS01_39610 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein VEGS01_39620 ENOG4105P4Z Phage shock protein G VEGS01_39630 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) VEGS01_39650 ENOG4105MYN Zinc uptake regulation protein VEGS01_39660 ENOG4105VDW Csbd family VEGS01_39670 ENOG4107R73 Mate efflux family protein VEGS01_39690 ENOG41080IJ Diacylglycerol kinase VEGS01_39750 ENOG4107W52 maltose operon periplasmic protein VEGS01_39770 ENOG4108IJ9 (ABC) transporter VEGS01_39780 ENOG4107FKK extracellular solute-binding protein family 1 VEGS01_39790 ENOG4105D56 permease protein VEGS01_39800 ENOG4105EG2 ABC transporter, permease VEGS01_39810 ENOG4107QNK )-transporter VEGS01_39830 ENOG4105E3R (LipO)protein VEGS01_39840 ENOG4108Q9C Periplasmic Protein VEGS01_39850 ENOG4108MDC (LipO)protein VEGS01_39870 ENOG4107QP8 phosphohexose isomerase VEGS01_39880 ENOG4105CFH Aspartokinase VEGS01_39890 ENOG4108ZR5 Conserved Protein VEGS01_39900 ENOG4105FE9 pseudouridine synthase VEGS01_39920 ENOG4105EAM Na Pi-cotransporter VEGS01_39930 ENOG4105C3R Methionine synthase VEGS01_39940 ENOG41069M3 Transcriptional regulator VEGS01_39960 ENOG4105VS7 Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation (By similarity) VEGS01_39970 ENOG4108I9X Isocitrate lyase VEGS01_39980 ENOG4107QP3 malate synthase g VEGS01_39990 ENOG4105CVG Homoserine O-transsuccinylase VEGS01_40000 ENOG4105K5X acetyltransferase VEGS01_40010 ENOG41062WK cellular response to acidity VEGS01_40020 ENOG4105DC1 bifunctional purine biosynthesis protein purh VEGS01_40030 ENOG4105C12 Phosphoribosylglycinamide synthetase VEGS01_40040 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family VEGS01_40050 ENOG4105BZU Histidine kinase VEGS01_40060 ENOG4105BZU Histidine kinase VEGS01_40070 ENOG4105JBU Binds zinc. Could be an important component of the zinc- balancing mechanism VEGS01_40080 ENOG4108T8B Protein of unknown function (DUF1481) VEGS01_40100 ENOG4105R2J Conserved Protein VEGS01_40170 ENOG4105D06 uba thif-type nad fad binding protein VEGS01_40180 ENOG4105WHD thiamine biosynthesis protein ThiS VEGS01_40190 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) VEGS01_40200 ENOG4105D41 biosynthesis protein thiH VEGS01_40210 ENOG410645W Thiamin biosynthesis protein ThiH VEGS01_40280 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) VEGS01_40290 ENOG4105PM1 preprotein translocase subunit SecE VEGS01_40320 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase VEGS01_40330 ENOG4105D4A Cell wall formation (By similarity) VEGS01_40340 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) VEGS01_40350 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) VEGS01_40370 ENOG4108Y73 Membrane VEGS01_40400 ENOG4105C5Q Transcriptional regulator VEGS01_40430 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase VEGS01_40440 ENOG4105CWC Acetylornithine deacetylase VEGS01_40460 ENOG4105DIJ Phosphoethanolamine transferase VEGS01_40470 ENOG4106R3P AraC family transcriptional regulator VEGS01_40480 ENOG4108XCZ PTS System VEGS01_40490 ENOG4108AHH pyruvate formate lyase II activase VEGS01_40510 ENOG4108YRF PTS System VEGS01_40520 ENOG4105DM4 PTS System VEGS01_40530 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) VEGS01_40540 ENOG4107T9Z Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) VEGS01_40550 ENOG4105DCT glycerol dehydrogenase VEGS01_40560 ENOG4108XC3 NADH ubiquinone oxidoreductase VEGS01_40570 ENOG4108Q5Y Membrane VEGS01_40590 ENOG4105SYT Methylenetetrahydrofolate reductase VEGS01_40600 ENOG4105CFH Aspartokinase VEGS01_40610 ENOG4105C28 cystathionine VEGS01_40630 ENOG4107S01 Repressor protein MetJ VEGS01_40650 ENOG4105C25 Primosomal protein n' VEGS01_40660 ENOG4105ETE Transcriptional regulator (LacI family VEGS01_40670 ENOG41063M6 Cell Division Protein VEGS01_40700 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase VEGS01_40720 ENOG4105N4M Non-essential, abundant cell division factor that is required for proper Z-ring formation. It is recruited early to the divisome by direct interaction with FtsZ, stimulating Z-ring assembly and thereby promoting cell division earlier in the cell cycle. Its recruitment to the Z-ring requires functional FtsA or ZipA (By similarity) VEGS01_40730 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) VEGS01_40750 ENOG4105CBT Fructose-1,6-bisphosphatase VEGS01_40760 ENOG4105DP0 ferredoxin-NADP reductase VEGS01_40780 ENOG41065TG regulatoR VEGS01_40790 ENOG4108VTS Membrane VEGS01_40800 ENOG4105EBK exported protein VEGS01_40830 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein VEGS01_40860 ENOG4105FMW periplasmic VEGS01_40870 ENOG4105E3W Two component transcriptional regulator (Winged helix family VEGS01_40880 ENOG4105E0F Histidine kinase VEGS01_40890 ENOG4108RPX mosc domain containing protein VEGS01_40910 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) VEGS01_40960 ENOG4105DKG l-rhamnose isomerase VEGS01_41000 ENOG41064BA PTS system, fructose-specific, IIA component VEGS01_41010 ENOG4105DM4 PTS System VEGS01_41020 ENOG4105CN9 Peptidase m42 family protein VEGS01_41030 ENOG4106C3V frv operon regulatory protein VEGS01_41040 ENOG4108V87 frv operon regulatory protein VEGS01_41060 ENOG4108MBK is1 orf2 VEGS01_41070 ENOG4108V87 frv operon regulatory protein VEGS01_41080 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) VEGS01_41100 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein VEGS01_41110 ENOG4108MG3 formate dehydrogenase VEGS01_41130 ENOG41068KX affects formate dehydrogenase-N VEGS01_41150 ENOG4105SUU thioesterase domain VEGS01_41180 ENOG4105EJU HAD-superfamily hydrolase subfamily IA variant 3 VEGS01_41190 ENOG4105E98 transcriptional regulator DeoR family VEGS01_41200 ENOG4108MGF sugar kinase VEGS01_41210 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase VEGS01_41220 ENOG4105D2M Aldolase VEGS01_41230 ENOG4107QKS N-acylglucosamine 2-epimerase VEGS01_41240 ENOG4107WI4 Aldose-1-epimerase VEGS01_41250 ENOG4105CJQ hydrolase, family 31 VEGS01_41260 ENOG4105CJQ hydrolase, family 31 VEGS01_41270 ENOG4105CT4 transporter VEGS01_41280 ENOG4105CT4 transporter VEGS01_41290 ENOG4108KUC Outer membrane channel protein that allows an efficient diffusion of low-molecular-weight solutes such as small sugars and tetraglycine. However, the specific substrate recognized by the OmpL channel is VEGS01_41320 ENOG4108KHF Resistance protein VEGS01_41330 ENOG4108K85 Transcriptional regulator VEGS01_41340 ENOG4105CI3 gtp-binding protein typa VEGS01_41350 ENOG4105C5F glutamine synthetase VEGS01_41360 ENOG4105CUX Signal transduction histidine kinase VEGS01_41370 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family VEGS01_41380 ENOG4105D4P Coproporphyrinogen iii oxidase VEGS01_41390 ENOG4105ZR3 A GTPase-activating protein (GAP) that modifies Der EngA GTPase function. May play a role in ribosome biogenesis (By similarity) VEGS01_41410 ENOG4105C2M dna polymerase I VEGS01_41430 ENOG4106HNH Acyl-transferase VEGS01_41450 ENOG4108Z33 Thiol disulfide Interchange Protein VEGS01_41460 ENOG4105E27 serine threonine protein kinase VEGS01_41470 ENOG4105PC1 Conserved Protein VEGS01_41480 ENOG4105C6R Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) VEGS01_41490 ENOG4105FNP Molybdopterin-guanine dinucleotide biosynthesis protein b VEGS01_41500 ENOG4108RR8 protoporphyrinogen oxidase VEGS01_41510 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) VEGS01_41520 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein VEGS01_41560 ENOG4108EX3 reductase VEGS01_41570 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) VEGS01_41580 ENOG4105MDZ Transcriptional activator rfaH VEGS01_41600 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) VEGS01_41610 ENOG4105X8U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity) VEGS01_41620 ENOG4105WKS Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) VEGS01_41640 ENOG4105JC1 sterol-binding domain protein VEGS01_41660 ENOG4105CGY Dna recombination protein VEGS01_41670 ENOG4108I5U Uridine phosphorylase VEGS01_41680 ENOG4105CDZ Carboxymethylenebutenolidase (EC 3.1.1.45) VEGS01_41690 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) VEGS01_41700 ENOG4105DZ2 Transcriptional regulator VEGS01_41710 ENOG4105EMK carboxylate amino acid amine transporter VEGS01_41720 ENOG4105DQF Hydrolase VEGS01_41730 ENOG4108EUD Lysophospholipase VEGS01_41740 ENOG410829K Lysine exporter protein (Lyse ygga) VEGS01_41750 ENOG4105CCF Lysine exporter protein (Lyse ygga) VEGS01_41760 ENOG4105C9U ATP-dependent DNA helicase RecQ VEGS01_41770 ENOG4105HDD phospholipase VEGS01_41780 ENOG4108VUY thioesterase Superfamily protein VEGS01_41790 ENOG4105FR1 rard protein VEGS01_41800 ENOG4105NRM Membrane VEGS01_41820 ENOG4107QUT magnesium and cobalt transport protein CorA VEGS01_41830 ENOG4108T58 Mg2 transport protein CorA VEGS01_41840 ENOG4105C4R Atp-dependent dna helicase VEGS01_41850 ENOG4105DFC had-superfamily hydrolase, subfamily ia, variant VEGS01_41870 ENOG4105CT0 Protein of unknown function, DUF484 VEGS01_41890 ENOG4105S7Z (LipO)protein VEGS01_41910 ENOG4107T0K Adenylate cyclase VEGS01_41920 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) VEGS01_41930 ENOG41076E6 Uroporphyrinogen-III Synthase VEGS01_41940 ENOG4105ECF c-methyltransferase VEGS01_41950 ENOG410601J HemY protein VEGS01_41960 ENOG4105ENH Sulfatase VEGS01_41970 ENOG4105C4X radical SAM domain protein VEGS01_41980 ENOG4105C85 amino acid VEGS01_41990 ENOG4108UHC Glycosyl transferase, wecb taga cpsf family VEGS01_42000 ENOG4105DAD Could be involved in ECA polysaccharide chain elongation (By similarity) VEGS01_42010 ENOG4105F18 Catalyzes the synthesis of Und-PP-GlcNAc-ManNAcA-Fuc4NAc (Lipid III), the third lipid-linked intermediate involved in ECA synthesis (By similarity) VEGS01_42020 ENOG4105EGZ biosynthesis protein VEGS01_42030 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase VEGS01_42040 ENOG4108WJ1 acetyltransferase VEGS01_42050 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) VEGS01_42060 ENOG4105C1B dTDP-glucose 4-6-dehydratase VEGS01_42070 ENOG4107QQG Dehydrogenase VEGS01_42080 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase VEGS01_42090 ENOG4105SFE lipopolysaccharide biosynthesis protein VEGS01_42100 ENOG4105ESV Glycosyl transferase, family 4 VEGS01_42110 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) VEGS01_42150 ENOG4105C4R Atp-dependent dna helicase VEGS01_42170 ENOG4105KQ5 peptidylprolyl cis-trans isomerase VEGS01_42190 ENOG4105EMY transcriptional regulator VEGS01_42200 ENOG4105C7B Threonine dehydratase VEGS01_42220 ENOG4105CM2 brancheD-chain amino acid aminotransferase VEGS01_42230 ENOG4105P3Y Acetolactate synthase 2 regulatory subunit VEGS01_42250 ENOG4105C0P Mg chelatase subunit ChlI VEGS01_42260 ENOG4108WFC UPF0438 protein yifE VEGS01_42280 ENOG4107EJG GntR family transcriptional regulator VEGS01_42290 ENOG4105C0R drug resistance transporter emrb qaca subfamily VEGS01_42300 ENOG4105ETE Transcriptional regulator (LacI family VEGS01_42310 ENOG4108RVA ribokinase VEGS01_42320 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator VEGS01_42330 ENOG4105CNN ABC, transporter VEGS01_42340 ENOG4105C2J ABC transporter VEGS01_42400 ENOG4108VVK transcriptional Regulator, AsnC VEGS01_42410 ENOG4105QTB Flavodoxin VEGS01_42440 ENOG4105GXX Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit I associates with the membrane and may be involved with cation translocation VEGS01_42540 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) VEGS01_42550 ENOG4107QMV Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity) VEGS01_42560 ENOG4105C8U phosphate abc transporter VEGS01_42570 ENOG4105E2Z phosphate ABC transporter (Permease VEGS01_42580 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) VEGS01_42590 ENOG4108UTW Plays a role in the regulation of phosphate uptake VEGS01_42600 ENOG4105CID antiterminator VEGS01_42610 ENOG4105C5Y PTS System VEGS01_42620 ENOG4105CS2 ec 3.2.1.21 VEGS01_42640 ENOG4105DYC esterase VEGS01_42650 ENOG4107VKM 6-phosphogluconolactonase VEGS01_42660 ENOG4106611 bacteriocin immunity VEGS01_42690 ENOG4107UB3 HAD-superfamily hydrolase subfamily IA variant 3 VEGS01_42700 ENOG4105C7N Xanthine uracil vitamin C permease VEGS01_42710 ENOG4108YYH Nadph-dependent fmn reductase VEGS01_42720 ENOG4105E8Q phosphopantetheinyl transferase VEGS01_42740 ENOG4105CNH Multidrug resistance protein MdtL VEGS01_42750 ENOG4108P6C Tryptophan transporter of low affinity VEGS01_42770 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) VEGS01_42780 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins VEGS01_42800 ENOG4105VG0 50S ribosomal protein l34