locus-tag class description AM338_00030 ENOG4105QUW AM338_00035 ENOG41090FC Bacteriophage N4 receptor, outer membrane subunit AM338_00040 ENOG410802X bacteriophage n4 adsorption protein b AM338_00045 ENOG4105GR3 Histidine kinase AM338_00050 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AM338_00060 ENOG4105ENJ RND efflux system, outer membrane lipoprotein AM338_00065 ENOG410624V efflux system protein AM338_00070 ENOG4105EP1 Efflux transporter rnd family, mfp subunit AM338_00075 ENOG4108IJF Heavy metal efflux pump, CzcA AM338_00080 ENOG4105C85 amino acid AM338_00085 ENOG4105CUY Mechanosensitive ion channel AM338_00090 ENOG4108RCM Nitroreductase AM338_00120 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase AM338_00125 ENOG4105CMR udp-glucose 4-epimerase AM338_00145 ENOG4105CPK Glycosyl transferase (Group 1 AM338_00150 ENOG4105CGN Glycosyl transferase (Group 1 AM338_00175 ENOG4107T8Q Glycosyl transferase (Group 1 AM338_00190 ENOG4105HVQ Regulatory factor of maltose metabolism AM338_00230 ENOG4107635 Hok Gef family protein AM338_00235 ENOG4108SER Transposase AM338_00240 ENOG4108TSE Transferase AM338_00245 ENOG4107RNH Outer membrane receptor FepA AM338_00250 ENOG4105E93 esterase AM338_00255 ENOG41085A6 mbth domain-containing protein AM338_00260 ENOG4105C0W non-ribosomal peptide synthetase AM338_00265 ENOG4108QY5 Ferric enterobactin transport protein AM338_00270 ENOG4105E0A ABC, transporter AM338_00275 ENOG4105TVJ transport system, permease AM338_00280 ENOG4105DQ5 transport system permease protein AM338_00290 ENOG4105PEC Iron-enterobactin transporter periplasmic binding protein AM338_00300 ENOG4105E4F Isochorismate synthase AM338_00305 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase AM338_00310 ENOG4105WQI isochorismatase AM338_00315 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase AM338_00320 ENOG4108TZA Required for optimal enterobactin synthesis. Acts as a proofreading enzyme that prevents EntB misacylation by hydrolyzing the thioester bound existing between EntB and wrongly charged molecules (By similarity) AM338_00325 ENOG4105D22 carbon starvation protein AM338_00330 ENOG4105VCD cytoplasmic protein AM338_00335 ENOG4107SCQ Iron-containing alcohol dehydrogenase AM338_00340 ENOG4105CHM Aminotransferase AM338_00345 ENOG4105GTN ParB Domain Protein Nuclease AM338_00350 ENOG4105BZV Phosphoadenosine phosphosulfate reductase AM338_00355 ENOG4105DQS Transcriptional regulator AM338_00365 ENOG4108KHN disulfide isomerase, thiol-disulfide oxidase AM338_00370 ENOG4105D3R alkyl hydroperoxide reductase AM338_00375 ENOG4108JU3 Alkyl hydroperoxide reductase AM338_00380 ENOG4108U51 Universal stress protein AM338_00400 ENOG4105E2A Dehydrogenase AM338_00410 ENOG4105NXH GreA GreB family elongation factor AM338_00420 ENOG4105KTS ribonuclease AM338_00425 ENOG4107QPK )-transporter AM338_00440 ENOG4105CHY citrate lyase, alpha AM338_00445 ENOG4105CI0 Citrate lyase AM338_00455 ENOG4105DUA (citrate (pro-3S)-lyase ligase AM338_00460 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism AM338_00465 ENOG4106YYS transcriptional regulatory protein AM338_00470 ENOG4105CEE C4-dicarboxylate transporter AM338_00480 ENOG41079UR PagP is required both for biosynthesis of hepta-acylated lipid A species containing palmitate and for resistance to cationic antimicrobial peptides (CAMPs). It catalyzes the transfer of a palmitate chain (16 0) from the sn-1 position of a glycerophospholipid to the free hydroxyl group of the (R)-3- hydroxymyristate chain at position 2 of lipid A (endotoxin) (By similarity) AM338_00485 ENOG4105VEQ Cold shock protein AM338_00500 ENOG410607N Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatE shares overlapping functions with TatA (By similarity) AM338_00515 ENOG41064T2 transcriptional regulator, lysR family AM338_00535 ENOG4105DZ1 carboxypeptidase AM338_00540 ENOG4105K6T rare lipoprotein A AM338_00545 ENOG4105CNI cell division protein FtsW AM338_00550 ENOG4105CJN penicillin-binding protein AM338_00560 ENOG4105KEM Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) AM338_00565 ENOG4108TGR phosphatase AM338_00575 ENOG4105DJF DNA polymerase III, delta' subunit AM338_00590 ENOG4107PAI alpha helical protein AM338_00595 ENOG4105EUU Sel1 domain protein repeat-containing protein AM338_00600 ENOG41069CF Protein of unknown function (DUF1266) AM338_00605 ENOG4105QFC Hsc56 co-chaperone of HscC AM338_00610 ENOG4107JFD Sel1 repeat AM338_00615 ENOG41069CF Protein of unknown function (DUF1266) AM338_00620 ENOG4105QFC Hsc56 co-chaperone of HscC AM338_00625 ENOG4105F7F Chaperone AM338_00635 ENOG4105CDA abc transporter atp-binding protein AM338_00640 ENOG4105DRP amino acid AbC transporter AM338_00645 ENOG4105EAD ABC transporter AM338_00650 ENOG4107RP9 extracellular solute-binding protein, family 3 AM338_00655 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) AM338_00660 ENOG4108JU5 Magnesium and cobalt efflux protein AM338_00670 ENOG4105C9A Phoh family AM338_00680 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family AM338_00725 ENOG4105CAQ asparagine synthetase AM338_00735 ENOG4105D4U had-superfamily hydrolase, subfamily iia AM338_00740 ENOG4105E2R ROK family AM338_00745 ENOG4105CE4 GlcNAc 6-P deacetylase AM338_00755 ENOG4105CI1 PTS System AM338_00770 ENOG4105GX6 (LipO)protein AM338_00775 ENOG41090R7 Ferric uptake AM338_00785 ENOG4105MHQ Low-potential electron donor to a number of redox enzymes (By similarity) AM338_00790 ENOG4105NNH LexA regulated protein AM338_00795 ENOG4105EV9 Alpha Beta Hydrolase AM338_00800 ENOG4107CDU Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated (By similarity) AM338_00805 ENOG4107QIX Phosphoglucomutase (EC 5.4.2.2 AM338_00825 ENOG4105D5Q Arginine ornithine antiporter AM338_00840 ENOG4105EEX Two component transcriptional regulator (Winged helix family AM338_00845 ENOG4105C08 Histidine kinase AM338_00870 ENOG4105XIQ Protein of unknown function (DUF2517) AM338_00875 ENOG4105CNA YD repeat protein AM338_00880 ENOG41079JQ Membrane AM338_00890 ENOG4106R09 AM338_00910 ENOG4107SEY Conserved Protein AM338_00915 ENOG4105CVP deoxyribo-dipyrimidine photolyase AM338_00920 ENOG4105DUX Transporter AM338_00925 ENOG4107QNR UPF0135 protein AM338_00930 ENOG4105P4J Allophanate hydrolase, subunit 1 AM338_00935 ENOG4107R7A Allophanate hydrolase subunit 2 AM338_00950 ENOG4108KK1 membrane protein AbrB duplication AM338_00955 ENOG4108MY7 Fimbrial AM338_00960 ENOG4108TTM chaperone AM338_00965 ENOG4106PG1 outer membrane usher protein AM338_00970 ENOG4106UBK fimbrial-like adhesin protein AM338_00975 ENOG4105BZN citrate synthase AM338_00990 ENOG4108UTY succinate dehydrogenase, cytochrome b556 subunit AM338_00995 ENOG4105N1I succinate dehydrogenase, hydrophobic membrane anchor protein AM338_01000 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) AM338_01005 ENOG4105E33 succinate dehydrogenase AM338_01010 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 AM338_01015 ENOG4105C7S Dehydrogenase AM338_01025 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha AM338_01035 ENOG4105FDP GntR family transcriptional regulator AM338_01040 ENOG4105DM4 PTS System AM338_01045 ENOG4105C8I hydrolase, family 38 AM338_01055 ENOG4105C4M (Ubiquinol oxidase) subunit I AM338_01060 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii AM338_01070 ENOG4105KJB cyd operon protein YbgE AM338_01075 ENOG4107YD3 Thioesterase AM338_01080 ENOG4105E02 MotA TolQ exbB proton channel AM338_01085 ENOG4105M8F Biopolymer transport protein exbD tolR AM338_01090 ENOG4108Z82 Cell envelope integrity inner membrane protein TolA AM338_01100 ENOG4105KCK Peptidoglycan-associated lipoprotein AM338_01105 ENOG4105UFD tol-pal system protein YbgF AM338_01155 ENOG4106Z1T Nicotinamide Mononucleotide Transporter AM338_01160 ENOG4105PGM cation diffusion facilitator family transporter AM338_01165 ENOG4105JND homeobox protein AM338_01175 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) AM338_01185 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) AM338_01195 ENOG4105F0Z galactose-1-phosphate uridylyltransferase AM338_01200 ENOG4105CMR udp-glucose 4-epimerase AM338_01205 ENOG4105DKW ABC transporter AM338_01210 ENOG4105F4R Transcriptional regulator mode AM338_01215 ENOG410680R Protein of unknown function (DUF2592) AM338_01225 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein AM338_01230 ENOG4105E0C molybdate abc transporter AM338_01235 ENOG4105CGB Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system (By similarity) AM338_01240 ENOG4108K4B hydrolase AM338_01250 ENOG4105F04 LysR family Transcriptional regulator AM338_01255 ENOG4105C7F AcnD-accessory protein PrpF AM338_01260 ENOG4107QPK )-transporter AM338_01265 ENOG4107QM5 aconitate hydratase AM338_01270 ENOG4105NBR Pectinesterase AM338_01280 ENOG4108V1U phospholipid-binding protein AM338_01285 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) AM338_01295 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) AM338_01300 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) AM338_01305 ENOG4105E78 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) AM338_01315 ENOG4105CHW UPF0052 protein AM338_01325 ENOG4108RIR Molybdenum cofactor biosynthesis protein AM338_01335 ENOG4105M00 molybdopterin converting factor, subunit 1 AM338_01340 ENOG4108ZAF Molybdopterin AM338_01345 ENOG4105HFZ Membrane AM338_01350 ENOG410733J conserved inner membrane protein AM338_01355 ENOG4107UXM Membrane AM338_01360 ENOG4105DZQ phospholipase D Transphosphatidylase AM338_01365 ENOG4105X23 Endonuclease Exonuclease phosphatase AM338_01370 ENOG4105I9U inner membrane protein ybhQ AM338_01375 ENOG4107QWP ABC-2 type transporter AM338_01380 ENOG4107QWP ABC-2 type transporter AM338_01385 ENOG4105CJ1 ABC, transporter AM338_01395 ENOG4107MVR Transcriptional regulator AM338_01400 ENOG4105C1J atp-dependent rna helicase AM338_01405 ENOG4108UV1 cellular component movement AM338_01415 ENOG4105DVT helicase AM338_01420 ENOG4108MTB glycosyl transferase family AM338_01425 ENOG4105DG4 malate L-lactate dehydrogenase AM338_01430 ENOG4105VR4 UPF0379 protein ybiJ AM338_01435 ENOG4105KSC Transcriptional regulator, TraR DksA family AM338_01445 ENOG4108IU3 tonb-dependent siderophore receptor AM338_01450 ENOG4105ZY9 UPF0379 protein ybiM AM338_01460 ENOG4105D8X mechanosensitive ion channel AM338_01465 ENOG4105CDA abc transporter atp-binding protein AM338_01470 ENOG4105E5Q amino acid AbC transporter AM338_01475 ENOG4107R0W ABC transporter AM338_01500 ENOG4107AQZ Membrane AM338_01505 ENOG4108T1M outer membrane protein x AM338_01510 ENOG4108I6E Sulfatase AM338_01520 ENOG4105KST dependent repressor AM338_01525 ENOG4105F4P )-transporter AM338_01530 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein AM338_01535 ENOG4105C5H ABC transporter AM338_01540 ENOG41072TH Protein of unknown function (DUF1479) AM338_01545 ENOG4108HCJ Hydrolase AM338_01550 ENOG4105C6N Formate acetyltransferase AM338_01555 ENOG4105F1A Pyruvate formate-lyase AM338_01560 ENOG4107T9Z Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) AM338_01565 ENOG4105D06 uba thif-type nad fad binding protein AM338_01570 ENOG4105CVM Molybdenum cofactor synthesis domain protein AM338_01575 ENOG4105D44 asparaginase AM338_01580 ENOG4108JQ6 ABC transporter AM338_01585 ENOG4105DEF Extracellular solute-binding protein, family 5 AM338_01595 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component AM338_01600 ENOG4105BZU Histidine kinase AM338_01605 ENOG41064RH membrane protein YliF AM338_01615 ENOG4105UFT Represses biofilm formation in M9C glu and LB glu media but not in M9C and LB media. Seems to act as a global regulator of several genes involved in catabolite repression and stress response and regulation of the uptake and export of signaling pathways. Could be involved the regulation of indole as well as uptake and export of AI-2 through a cAMP-dependent pathway AM338_01620 ENOG4105D8V Glucose sorbosone dehydrogenase AM338_01625 ENOG4108TGY Glutathione S-transferase AM338_01630 ENOG4105DZ1 carboxypeptidase AM338_01635 ENOG4107FB0 transcriptional regulator DeoR family AM338_01640 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase AM338_01645 ENOG4107QF7 multi-drug AM338_01655 ENOG4108HCJ Hydrolase AM338_01660 ENOG4106UW1 Major Facilitator superfamily AM338_01665 ENOG4108RFG Tetr family transcriptional regulator AM338_01675 ENOG4105GWF inner membrane protein YbjM AM338_01680 ENOG41090BQ Glutaredoxin AM338_01685 ENOG4105X20 member of the soxRS regulon which mediates in part the increased levels of superoxide in response to oxidative stress AM338_01690 ENOG4108DBC nitroreductase AM338_01700 ENOG4108RMJ sensory transduction regulator AM338_01710 ENOG4107RUE extracellular solute-binding protein family 1 AM338_01715 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) AM338_01720 ENOG4105F38 ABC transporter, permease AM338_01725 ENOG4105D38 putrescine abc transporter AM338_01730 ENOG4105RBQ inner membrane protein ybjO AM338_01740 ENOG4106TNF Periplasmic binding protein AM338_01745 ENOG4105DMR ABC, transporter AM338_01750 ENOG4105GBT ABC transporter AM338_01755 ENOG4106PMH Extracellular solute-binding protein family 3 AM338_01760 ENOG4105E5Z arginine transporter ATP-binding subunit AM338_01765 ENOG41064MM (LipO)protein AM338_01775 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase AM338_01780 ENOG4107VBM 3-beta hydroxysteroid dehydrogenase isomerase AM338_01785 ENOG4105CGD Nad-dependent epimerase dehydratase AM338_01790 ENOG4105C5W Aldolase AM338_01795 ENOG4105C7K acetolactate synthase AM338_01800 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) AM338_01810 ENOG4105DWU Membrane AM338_01820 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) AM338_01825 ENOG4105CPB ATP-dependent endonuclease of the OLD family AM338_01830 ENOG4108MJ5 VirK protein AM338_01835 ENOG4105DJY efflux transporter, rnd family, mfp subunit AM338_01840 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) AM338_01845 ENOG4105VEQ Cold shock protein AM338_01900 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) AM338_01930 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit AM338_01940 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) AM338_01955 ENOG4108JJ8 (ABC) transporter AM338_01960 ENOG4108JJ9 ABC, transporter AM338_01965 ENOG4105C3M thioredoxin reductase AM338_01975 ENOG4105EW9 transcriptional regulator AsnC family AM338_01980 ENOG4105CNU cell division protein FtsK AM338_01990 ENOG4105D1H recombination factor protein RarA AM338_02000 ENOG4107QY8 reductase AM338_02005 ENOG4105QAX Iron-sulfur AM338_02010 ENOG4107KGK dmso reductase anchor subunit AM338_02015 ENOG4105CHJ isochorismatase hydrolase AM338_02025 ENOG4105E5D amino acid AM338_02030 ENOG410642W LysR family Transcriptional regulator AM338_02035 ENOG4108X0B nad(p)h dehydrogenase (quinone) AM338_02040 ENOG4105F1A Pyruvate formate-lyase AM338_02045 ENOG4105C6N Formate acetyltransferase AM338_02050 ENOG4105TMB Formate nitrite transporter AM338_02055 ENOG4105DDY UPF0142 protein ycaO AM338_02060 ENOG4107VMU Membrane AM338_02075 ENOG4108K0D peptidase, M48 AM338_02085 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) AM338_02095 ENOG4108EQH DNA internalization-related competence protein ComEC Rec2 AM338_02100 ENOG4105BZ1 (ABC) transporter AM338_02105 ENOG4105CHD Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity) AM338_02110 ENOG4105T0Z Conserved Protein AM338_02125 ENOG4107VR7 transferase activity, transferring phosphorus-containing groups AM338_02130 ENOG4107S90 membrAne AM338_02140 ENOG4106371 Methyltransferase AM338_02150 ENOG4105DAH Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF (By similarity) AM338_02160 ENOG4105DIT ErfK YbiS YcfS YnhG family protein AM338_02170 ENOG4105EAQ (twin-arginine translocation) pathway signal AM338_02175 ENOG4105C5X domain protein AM338_02185 ENOG4105CGF Aromatic amino acid aminotransferase AM338_02235 ENOG4105CD8 aminopeptidase N AM338_02240 ENOG4105E2Y ABC, transporter AM338_02245 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component AM338_02255 ENOG4105GVF (ABC) transporter AM338_02260 ENOG4108UZX fmn reductase AM338_02270 ENOG41071VI Part of the elfADCG-ycbUVF fimbrial operon, which promotes adhesion of bacteria to different abiotic surfaces. ElfA is the major fimbrial subunit produced by this operon AM338_02275 ENOG4106JJN Part of the elfADCG-ycbUVF fimbrial operon, which promotes adhesion of bacteria to different abiotic surfaces. Could be required for the biogenesis of the ElfA fimbriae AM338_02280 ENOG4105CW0 outer membrane usher protein AM338_02285 ENOG4108MDY Fimbrial AM338_02290 ENOG4105Q7J Fimbrial AM338_02295 ENOG4105MX3 Fimbrial AM338_02300 ENOG4106PH7 chaperone AM338_02310 ENOG4108T7E Contributes to the efficiency of the cell division process by stabilizing the polymeric form of the cell division protein FtsZ. Acts by promoting interactions between FtsZ protofilaments and suppressing the GTPase activity of FtsZ (By similarity) AM338_02315 ENOG4105QVC MOSC domain-containing protein AM338_02320 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) AM338_02325 ENOG4105C5H ABC transporter AM338_02330 ENOG4105F1S paraquat-inducible protein a AM338_02335 ENOG4105DY2 Paraquat-inducible protein b AM338_02340 ENOG4108Q2G (LipO)protein AM338_02345 ENOG4105WFT During stationary phase, converts 70S ribosomes to an inactive dimeric form (100S ribosomes) (By similarity) AM338_02355 ENOG4105DAN ATP-dependent protease AM338_02365 ENOG4105UYK outer membrane protein a AM338_02380 ENOG4108RZ1 DNA transformation protein AM338_02385 ENOG4105EM2 membrane AM338_02390 ENOG410901E Membrane AM338_02395 ENOG41088T4 Helicase IV AM338_02410 ENOG4105K4P CoA-binding domain protein AM338_02425 ENOG4105VSY K01512 acylphosphatase EC 3.6.1.7 AM338_02430 ENOG4108Z0T Part of a sulfur-relay system (By similarity) AM338_02435 ENOG4108MN8 Membrane AM338_02445 ENOG4105E3S small subunit AM338_02450 ENOG4105DPX Hydrogenase, large subunit AM338_02455 ENOG4105X7T Ni Fe-hydrogenase, b-type cytochrome subunit AM338_02460 ENOG4108USZ hydrogenase AM338_02465 ENOG4108VXY Hydrogenase-1 operon protein HyaE AM338_02470 ENOG4105MVP hydrogenase-1 operon protein HyaF AM338_02475 ENOG4105C4M (Ubiquinol oxidase) subunit I AM338_02480 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii AM338_02490 ENOG4105D6F Phosphatase AM338_02495 ENOG4105D75 Capsular exopolysaccharide family AM338_02500 ENOG4107ZF2 Phosphatase AM338_02505 ENOG4105DAY polysaccharide export protein AM338_02510 ENOG4105E3R (LipO)protein AM338_02515 ENOG4108W78 Pfam:DUF1017 AM338_02520 ENOG4108Y9B (LipO)protein AM338_02530 ENOG41060EU Cold shock-like protein AM338_02535 ENOG4105VEQ Cold shock protein AM338_02550 ENOG4106H71 Overexpression increases levels of unsaturated fatty acids and suppresses both the temperature-sensitive fabA6 mutation and cold-sensitive secG null mutation AM338_02555 ENOG4105HEE Binding Domain protein AM338_02560 ENOG4105BZU Histidine kinase AM338_02565 ENOG4108SV3 Tmao reductase system periplasmic protein tort AM338_02570 ENOG4106WF9 DNA-binding transcriptional regulator TorR AM338_02575 ENOG4105CUW cytochrome C-TYPE protein AM338_02580 ENOG4107QY8 reductase AM338_02585 ENOG4108SBI Involved in the biogenesis of TorA. Acts on TorA before the insertion of the molybdenum cofactor and, as a result, probably favors a conformation of the apoenzyme that is competent for acquiring the cofactor (By similarity) AM338_02605 ENOG4105D6F Phosphatase AM338_02610 ENOG4105XH3 AM338_02625 ENOG4105XF5 Escherichia coli IMT2125 genomic chromosome, IMT2125 AM338_02630 ENOG4105C2W permease AM338_02645 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) AM338_02665 ENOG4108R86 Transcriptional regulator AM338_02670 ENOG4105C26 Dehydrogenase AM338_02685 ENOG4105CK7 Sodium proline symporter AM338_02700 ENOG4105EKT )-iron permease AM338_02705 ENOG410650H (LipO)protein AM338_02710 ENOG4105DBE peroxidase AM338_02720 ENOG4105D5M phosphate starvation-inducible protein AM338_02725 ENOG4106FQ9 Biofilm PGA synthesis protein PgaD AM338_02730 ENOG4105CND Glycosyl transferase, family 2 AM338_02735 ENOG4107BJW polysaccharide deacetylase AM338_02740 ENOG4108TUY outer membrane protein PgaA AM338_02745 ENOG4105BZU Histidine kinase AM338_02760 ENOG4108T85 Membrane AM338_02785 ENOG4107XHZ cytoplasmic chaperone TorD family protein AM338_02790 ENOG4108UQ5 membrane protein YcdZ AM338_02795 ENOG4105P8Q Curli production assembly transport component CsgG AM338_02800 ENOG4108WYR Curli production assembly transport component, CsgF AM338_02805 ENOG4108XDW curli assembly protein CsgE AM338_02810 ENOG41086KC Transcriptional regulator AM338_02825 ENOG4108U0V Curli are coiled surface structures that assemble preferentially at growth temperatures below 37 degrees Celsius. Curli can bind to fibronectin. The minor subunit is the nucleation component of curlin monomers AM338_02830 ENOG4105G76 Curli are coiled surface structures that assemble preferentially at growth temperatures below 37 degrees Celsius. Curli can bind to fibronectin AM338_02835 ENOG4105RK8 Plays a role in the extracellular assembly of CsgA into thin aggregative fimbriae (Tafi) fibers. Assembly may also require CsgE. Tafi are thought to be assembled via an extracellular nucleation-precipitation (ENP) pathway, and possibly also via an intracellular non-CsgC-dependent pathway (By similarity) AM338_02845 ENOG4108UVJ appr-1-p processing domain protein AM338_02850 ENOG4107RZC phospholipase d AM338_02875 ENOG4105C3A Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs) (By similarity) AM338_02880 ENOG4105NAC (LipO)protein AM338_02885 ENOG4108W47 Acidic protein msyB AM338_02895 ENOG4105D1S lipid A biosynthesis AM338_02905 ENOG4108YYC ycei family AM338_02910 ENOG4105DS1 cytochrome b561 AM338_02915 ENOG4106974 biofilm formation AM338_02925 ENOG4105PVA Biofilm formation regulatory protein BssS AM338_02930 ENOG4105MEA DNA damage-inducible protein i AM338_02940 ENOG4105F3T (LipO)protein AM338_02945 ENOG4105E9S glutaredoxin 2 AM338_02955 ENOG4105D9U N-acetyltransferase AM338_02965 ENOG4105EP9 oxidoreductase AM338_02970 ENOG4105CJR Integral membrane protein (MviN AM338_02975 ENOG4105QVD Flagella synthesis protein FlgN AM338_02980 ENOG4105M9M anti-sigma28 factor FlgM AM338_02985 ENOG4105CKS Flagella basal body P-ring formation protein flgA AM338_02990 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) AM338_02995 ENOG4108ZC9 flagellar basal-body rod protein flgc AM338_03000 ENOG4105W00 Flagellar hook capping protein AM338_03005 ENOG4105BZE flagellar hook protein, FlgE AM338_03010 ENOG4108KPB Flagellar basal-body rod protein FlgF AM338_03015 ENOG4105CGA flagellar basal-body rod protein FlgG AM338_03030 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj AM338_03035 ENOG4105E1Q flagellar hook-associated protein AM338_03040 ENOG4105DTJ flagellar hook-associated protein AM338_03045 ENOG4107QQB Ribonuclease E AM338_03050 ENOG41071G1 Uncharacterized protein YceQ AM338_03060 ENOG4105EI2 Pseudouridine synthase AM338_03065 ENOG4108UHJ MAF-like protein AM338_03070 ENOG4105FCQ metal-binding, possibly nucleic acid-binding protein AM338_03090 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase AM338_03095 ENOG4105CHR reductase AM338_03100 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) AM338_03105 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) AM338_03110 ENOG4105YAZ 4-amino-4-deoxychorismate lyase AM338_03115 ENOG4105HHA aminodeoxychorismate lyase AM338_03125 ENOG4107QRG dna polymerase iii AM338_03130 ENOG4105F8V Hydrolase, tatD family AM338_03135 ENOG4105CI1 PTS System AM338_03140 ENOG4105CNM Receptor AM338_03145 ENOG4105K59 histidine triad (HIT) protein AM338_03150 ENOG41090DQ Lipoprotein AM338_03155 ENOG4108WEF Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b) (By similarity) AM338_03175 ENOG4105CEP NADH dehydrogenase AM338_03185 ENOG4107MBR 17 kDa surface antigen AM338_03190 ENOG4108IND Tetr family transcriptional regulator AM338_03195 ENOG4105RC8 Reduces the permeability of the outer membrane to copper. Seems to be involved in the regulation of biofilm formation. May decrease biofilm formation by repressing cell-cell interaction and cell surface interaction AM338_03200 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein AM338_03205 ENOG4108JA2 transcriptioN-repair coupling factor AM338_03210 ENOG4105IQC Inner membrane protein YcfT AM338_03215 ENOG4105D60 lipoprotein releasing system transmembrane protein AM338_03220 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) AM338_03225 ENOG4105D60 lipoprotein releasing system transmembrane protein AM338_03235 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) AM338_03250 ENOG4107RUE extracellular solute-binding protein family 1 AM338_03255 ENOG4105D38 putrescine abc transporter AM338_03260 ENOG4108I1J Integrase AM338_03270 ENOG41076J9 exonuclease VIII AM338_03275 ENOG4106G8A Qin prophage AM338_03350 ENOG4105WI6 cell killing protein encoded within cryptic prophage AM338_03360 ENOG4108MXB Protein of unknown function (DUF968) AM338_03365 ENOG4105KSK (crossover) junction endodeoxyribonuclease AM338_03370 ENOG4105HGD Antitermination protein AM338_03405 ENOG4105QFS Lysis protein S homolog from lambdoid prophage AM338_03430 ENOG4105QYK bacteriophage lambda Bor protein homolog AM338_03555 ENOG4105EKQ RNA-directed DNA polymerase AM338_03585 ENOG4108WF3 methyltransferase AM338_03595 ENOG4105F38 ABC transporter, permease AM338_03600 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) AM338_03615 ENOG4105EZE Cupin 4 family protein AM338_03620 ENOG4105IFJ Histidine kinase AM338_03625 ENOG4105XJC Two component transcriptional regulator (Winged helix family AM338_03630 ENOG4107QTF adenylosuccinate lyase AM338_03650 ENOG4108R99 pseudouridine synthase AM338_03655 ENOG4108HMX isocitrate dehydrogenase (NADP) AM338_03665 ENOG41064WM Uncharacterized protein YcgX AM338_03670 ENOG4108XDN Transcriptional regulator AM338_03675 ENOG4105BZU Histidine kinase AM338_03680 ENOG4105WKE Probably a connector protein for RcsB C regulation of biofilm formation, providing additional signal input into the two- component signaling pathway. Partially antagonizes the activities of YmgA and AriR, proteins that, via the Rcs phosphorelay, promote the synthesis of colanic acid, an exopolysaccharide and matrix component AM338_03685 ENOG41077SS Probably a connector protein for RcsB C regulation of biofilm formation, providing additional signal input into the two- component signaling pathway. May serve to stimulate biofilm maturation, probably via the Rcs phosphorelay. Mild overexpression at 16 degrees Celsius increases the production of colanic acid, an exopolysaccharide and matrix component, and reduces adhesive curli fimbriae expression. Both of these effects require RcsB AM338_03695 ENOG410738I uncharacterized protein ymgC AM338_03700 ENOG4105BZU Histidine kinase AM338_03755 ENOG4107QMS site-determining protein AM338_03770 ENOG4105S66 prophage protein AM338_03775 ENOG41066UD Inhibits activity of g-type lysozyme, which confers increased lysozyme tolerance to the bacterium AM338_03790 ENOG4105FBJ fumarylacetoacetate (faa) hydrolase AM338_03800 ENOG4106PXS Toxin, which has some hemolytic activity towards mammalian cells. Acts by forming a pore-like structure upon contact with mammalian cells AM338_03805 ENOG4105KT5 UmuD protein AM338_03810 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) AM338_03815 ENOG410635M Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein (By similarity) AM338_03830 ENOG4105ED1 spovr family AM338_03840 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) AM338_03850 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A AM338_03865 ENOG4108T7K Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Increasing levels of c-di-GMP lead to decreased motility (By similarity) AM338_03870 ENOG4105Y3U Transglycosylase-associated protein AM338_03890 ENOG4105VDH Dihydroxyacetone kinase AM338_03895 ENOG4108UTZ Dihydroxyacetone kinase AM338_03900 ENOG4105CMT Dihydroxyacetone kinase AM338_03905 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family AM338_03910 ENOG4105I1J Autotransporter AM338_03925 ENOG4105C3G gtp-binding protein AM338_03935 ENOG4105MGX transcription activated by CRP (cyclic AMP receptor protein), a global transcription factor involved in regulation of metabolism in enteric bacteria AM338_03940 ENOG4105CHH sulfate transporter AM338_03945 ENOG4105C5T Phosphoribosyl pyrophosphate synthase AM338_03950 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) AM338_03960 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) AM338_03970 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) AM338_03975 ENOG4108YY7 Invasion gene expression up-regulator SirB AM338_03980 ENOG41063JG Transcriptional regulator AM338_04015 ENOG4105EWV Sodium calcium exchanger membrane region AM338_04020 ENOG4105WS7 Cation transport regulator AM338_04025 ENOG4108NH8 Cation transport protein AM338_04030 ENOG41090EX DsrE family AM338_04035 ENOG4105ID0 Putative invasin AM338_04040 ENOG4105WH1 Two component transcriptional regulator luxr family AM338_04045 ENOG4105BZU Histidine kinase AM338_04055 ENOG4105DQQ Major facilitator superfamily MFS_1 AM338_04060 ENOG4105CRU nitrate reductase, alpha subunit AM338_04065 ENOG4108IUE nitrate reductase beta subunit AM338_04070 ENOG4105R3A Nitrate reductase AM338_04075 ENOG41076YT nitrate reductase, gamma subunit AM338_04110 ENOG4105CIY formyltetrahydrofolate deformylase AM338_04120 ENOG4105D78 K07001 NTE family protein AM338_04125 ENOG4105I93 response regulator AM338_04130 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase AM338_04135 ENOG4108SAU DNA-binding protein H-ns AM338_04140 ENOG4107104 thymidine kinase AM338_04150 ENOG4108EKI Dehydrogenase AM338_04155 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein AM338_04165 ENOG4108J59 Extracellular solute-binding protein, family 5 AM338_04175 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component AM338_04180 ENOG4105C3U ABC transporter AM338_04185 ENOG4108JQ7 (ABC) transporter AM338_04205 ENOG4107SVH Potassium channel protein AM338_04210 ENOG4105K9H YciI-like protein AM338_04215 ENOG410822N TonB family AM338_04220 ENOG4105NAU thioesterase Superfamily protein AM338_04240 ENOG4105EIF outer membrane protein W AM338_04245 ENOG4108N8X transition metal ion binding AM338_04250 ENOG4108Z9Z response to DNA damage stimulus AM338_04270 ENOG4105DK0 Indole-3-glycerol phosphate synthase AM338_04275 ENOG4108EFP Anthranilate synthase component II AM338_04280 ENOG4105CRQ synthase (Component I) AM338_04290 ENOG4105DB7 PHP domain protein AM338_04295 ENOG4107RTD sua5 ycio yrdc ywlc family protein AM338_04300 ENOG4105EG3 transmembrane signal peptide protein AM338_04305 ENOG4105FE9 pseudouridine synthase AM338_04310 ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase AM338_04315 ENOG4105UBK short-chain dehydrogenase reductase AM338_04320 ENOG4105ERU peptidase AM338_04325 ENOG4105RKX Protein of unknown function (DUF2498) AM338_04335 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) AM338_04345 ENOG4107R11 Transcriptional regulator AM338_04375 ENOG4107QM5 aconitate hydratase AM338_04385 ENOG4105EYK Phosphatidylglycerophosphatase B AM338_04390 ENOG4105Q4A inner membrane protein yciS AM338_04395 ENOG4105CFV Tetratricopeptide repeat protein AM338_04405 ENOG4108ZJT translation initiation factor, Sui1 AM338_04410 ENOG41061RM osmotically inducible lipoprotein AM338_04415 ENOG4105N2W Transcriptional regulator AM338_04425 ENOG4105BZU Histidine kinase AM338_04440 ENOG4105Q4T oxidoreductase AM338_04445 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH AM338_04450 ENOG4105WDY DNA (cytosine-5-)-methyltransferase AM338_04455 ENOG4108JQ2 peptide transport system atp-binding protein AM338_04460 ENOG4108JQ3 Peptide ABC transporter ATP-binding protein AM338_04465 ENOG4108EU3 peptide transport system, permease AM338_04470 ENOG4108I5W peptide transport system, permease protein AM338_04475 ENOG4108HIY periplasmic AM338_04485 ENOG4105N0E Protein of unknown function (DUF2543) AM338_04490 ENOG4105CUB amino acid AM338_04495 ENOG4105CFQ glutamine synthetase AM338_04500 ENOG4108Z86 Glutamine amidotransferase AM338_04505 ENOG4107VRI Transcriptional regulator AM338_04515 ENOG4105C26 Dehydrogenase AM338_04520 ENOG4105CJP fad dependent oxidoreductase AM338_04525 ENOG4108JPW Aminotransferase AM338_04530 ENOG4105E51 psp operon transcriptional activator AM338_04535 ENOG41087YS Phage shock protein A AM338_04540 ENOG4105YYT phage shock protein B AM338_04545 ENOG4105FM1 phage shock protein C AM338_04550 ENOG4105NNG Peripheral inner membrane phage-shock protein AM338_04555 ENOG4105K8Z Phage shock protein AM338_04560 ENOG4107QW3 Sucrose phosphorylase AM338_04570 ENOG4105HS6 binding-protein-dependent transport systems inner membrane Component AM338_04575 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component AM338_04580 ENOG4107RRD Dehydrogenase AM338_04585 ENOG4107TYA transient receptor potential locus AM338_04590 ENOG4105CK5 oxidoreductase AM338_04595 ENOG4105C71 hydrolase family 65, central catalytic AM338_04600 ENOG4107URF beta-phospho-glucomutase AM338_04605 ENOG4108IJ9 (ABC) transporter AM338_04610 ENOG4107EFV Outer membrane protein G AM338_04615 ENOG4105FKQ transcriptional regulator AM338_04620 ENOG4105CM6 amino acid regulated cytosolic protein AM338_04630 ENOG4108JU8 Transcriptional regulator AM338_04635 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) AM338_04640 ENOG4107S8C mandelate racemase muconate lactonizing AM338_04645 ENOG4105KXI murein peptide amidase A AM338_04655 ENOG4105ENX hydrolase AM338_04660 ENOG4105EQ2 LysR family Transcriptional regulator AM338_04670 ENOG4107QSI ABC, transporter AM338_04675 ENOG4105D64 Mechanosensitive ion channel AM338_04680 ENOG4105S5I Membrane AM338_04685 ENOG4105Q9Y Universal stress protein AM338_04690 ENOG4105DS0 Transcriptional regulator, Crp Fnr family AM338_04695 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) AM338_04700 ENOG4105CFC Transporter AM338_04710 ENOG4107RT5 aminobenzoyl-glutamate utilization protein B AM338_04715 ENOG4105CH2 amidohydrolase AM338_04720 ENOG4106KR7 LysR family Transcriptional regulator AM338_04730 ENOG4108DG9 Smr protein MutS2 AM338_04735 ENOG4105BZU Histidine kinase AM338_04750 ENOG4105C1J atp-dependent rna helicase AM338_04760 ENOG4108RW8 Universal stress protein F AM338_04765 ENOG4105FCK Membrane AM338_04775 ENOG4105D95 Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity) AM338_04785 ENOG41090X5 Heat shock protein hslJ AM338_04790 ENOG4105C5I Dehydrogenase AM338_04795 ENOG4107H52 Dicarboxylate transport AM338_04800 ENOG410689M (LipO)protein AM338_04805 ENOG4105WXT Conserved Protein AM338_04810 ENOG4108WFR AraC Family Transcriptional Regulator AM338_04815 ENOG4105C26 Dehydrogenase AM338_04820 ENOG4105F11 amine oxidase AM338_04825 ENOG4105DXM phenylacetic acid degradation protein AM338_04830 ENOG4105CRS phenylacetate-CoA oxygenase PaaG subunit AM338_04835 ENOG4105N76 Phenylacetate-CoA oxygenase, subunit AM338_04840 ENOG4105D9S phenylacetate-CoA oxygenase PaaI subunit AM338_04845 ENOG4108ZA2 phenylacetate-CoA oxygenase PaaJ subunit AM338_04850 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) AM338_04855 ENOG4105E39 Enoyl-CoA hydratase AM338_04860 ENOG4108UKI Enoyl-CoA hydratase AM338_04865 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase AM338_04870 ENOG4108ZJI phenylacetic acid degradation protein AM338_04875 ENOG4105CHU acetyl-coa acetyltransferase AM338_04880 ENOG4105DZS Phenylacetate-CoA ligase AM338_04885 ENOG4105V9J phenylacetic acid degradation operon negative regulatory protein AM338_04890 ENOG4108Z0R Transferase AM338_04915 ENOG4107EF2 surface-exposed virulence protein AM338_04920 ENOG4107S5I aldo keto reductase AM338_04930 ENOG4108UMZ Cdp-alcohol phosphatidyltransferase AM338_04935 ENOG4108HPI phosphatidate Cytidylyltransferase AM338_04940 ENOG4105E8V Alpha Beta Hydrolase Fold protein AM338_04945 ENOG41077RS Phosphatase AM338_04955 ENOG4105CQ7 ATP-dependent helicase AM338_04960 ENOG4107DB1 DUF218 domain AM338_04965 ENOG4105C26 Dehydrogenase AM338_04980 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase AM338_04985 ENOG4105CPW cytochrome b561 AM338_04990 ENOG4105UPP uncharacterized protein ydcA AM338_04995 ENOG4107NK6 Hok/gef family AM338_05000 ENOG4105C8Q Methyl-accepting chemotaxis AM338_05005 ENOG4105DDW LysR family Transcriptional regulator AM338_05010 ENOG4105E32 cytoplasmic protein AM338_05030 ENOG4105Z2P Protein of unknown function (DUF465) AM338_05035 ENOG4108Z9I -acetyltransferase AM338_05040 ENOG4107WE3 acetyltransferase YdcK AM338_05045 ENOG4108NKP c4-dicarboxylate transporter malic acid transport protein AM338_05050 ENOG41088CC tellurite resistance protein tehB AM338_05055 ENOG4108KKZ (LipO)protein AM338_05065 ENOG4105D7V transposase AM338_05070 ENOG4105DKK Benzoate AM338_05075 ENOG4108JCI Transcriptional regulator AM338_05080 ENOG4105CFP Peptidase U32 AM338_05085 ENOG4105RR0 Protein of unknown function (DUF2554) AM338_05095 ENOG4105PF0 Antitoxin component of a toxin-antitoxin (TA) module. Functions as an mRNA interferase antitoxin AM338_05100 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family AM338_05105 ENOG4107TYH extracellular solute-binding protein family 1 AM338_05110 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) AM338_05115 ENOG4105D81 ABC transporter, permease AM338_05120 ENOG4105NRK Binding-protein-dependent transport systems, inner membrane component AM338_05140 ENOG410654E Membrane AM338_05145 ENOG4105R71 cytoplasmic protein AM338_05150 ENOG4108T9Y Inner membrane protein ydcZ AM338_05155 ENOG4108Z7F N-acetyltransferase AM338_05165 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein AM338_05170 ENOG4108WYP Transcriptional regulator AM338_05175 ENOG4105CHB tonB-dependent Receptor AM338_05190 ENOG4108NS2 receptor AM338_05195 ENOG4105C85 amino acid AM338_05200 ENOG4108N27 Glutathione S-transferase AM338_05210 ENOG4105CS6 Rhs element vgr protein AM338_05215 ENOG4105CNA YD repeat protein AM338_05230 ENOG410600T transposase AM338_05240 ENOG4108MEJ flavin reductase domain protein AM338_05245 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase AM338_05250 ENOG4105JAB phenazine biosynthesis protein, phzf family AM338_05255 ENOG4105D0D Nitrate reductase 2, gamma subunit AM338_05260 ENOG4108NZN Respiratory nitrate reductase 2 delta chain AM338_05265 ENOG4108IUE nitrate reductase beta subunit AM338_05275 ENOG4107QND Nitrite extrusion protein AM338_05295 ENOG4105RPH Inner membrane protein YddG AM338_05300 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) AM338_05305 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) AM338_05310 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein AM338_05315 ENOG4108MG3 formate dehydrogenase AM338_05320 ENOG41084S7 Plasmid maintenance system antidote protein AM338_05325 ENOG4105DQ4 alcohol dehydrogenase AM338_05335 ENOG4107AV5 Although this protein associates with the 30S subunit of the ribosome it is not considered to be a bona fide ribosomal protein AM338_05340 ENOG4105TPS biofilm-dependent modulation protein AM338_05350 ENOG4108Z9K Osmotically inducible protein AM338_05355 ENOG4107H6U ABC transporter AM338_05360 ENOG4105C3U ABC transporter AM338_05365 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component AM338_05370 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component AM338_05375 ENOG4105DEF Extracellular solute-binding protein, family 5 AM338_05380 ENOG4108UQS dipeptidase AM338_05385 ENOG4105BZU Histidine kinase AM338_05390 ENOG4105BZU Histidine kinase AM338_05395 ENOG4105F32 YngK protein AM338_05400 ENOG4105E5D amino acid AM338_05405 ENOG4105CVK Glutamate decarboxylase AM338_05410 ENOG4107RAN Peptidase, M16 AM338_05415 ENOG4105PE1 Receptor AM338_05420 ENOG4105CQ0 ABC transporter AM338_05425 ENOG4105C4X radical SAM domain protein AM338_05430 ENOG4105ENH Sulfatase AM338_05435 ENOG4105Z68 AraC Family Transcriptional Regulator AM338_05445 ENOG4107QKC Oxidoreductase alpha (molybdopterin) subunit AM338_05450 ENOG4106PIH fimbrial-like protein ydeQ AM338_05455 ENOG4106318 fimbrial-like protein YdeR AM338_05460 ENOG4108WDE Fimbrial protein AM338_05475 ENOG4105CAF HipA N-terminal domain protein AM338_05480 ENOG41061P8 Persistence to inhibition of murein or DNA biosynthesis regulatory protein AM338_05495 ENOG4108EMV Catalyzes the phosphorylation of autoinducer 2 (AI-2) to phospho-AI-2, which subsequently inactivates the transcriptional regulator LsrR and leads to the transcription of the lsr operon. Phosphorylates the ring-open form of 4,5-dihydroxy-2,3- pentanedione (DPD), which is the precursor to all AI-2 signaling molecules, at the C5 position (By similarity) AM338_05500 ENOG4105DKT Transcriptional regulator AM338_05505 ENOG4105C2J ABC transporter AM338_05510 ENOG41071MT Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane AM338_05515 ENOG4105F5R ABC transporter AM338_05520 ENOG4105D4B ABC, transporter AM338_05525 ENOG41061GT Aldolase AM338_05530 ENOG4105K34 Involved in the degradation of phospho-AI-2, thereby terminating induction of the lsr operon and closing the AI-2 signaling cycle. Catalyzes the cleavage of phosphorylated 4,5- dihydroxy-2,3-pentanedione (P-DPD) to 2-phosphoglycolic acid (PG) and another three-carbon compound AM338_05540 ENOG4105FFC UPF0187 protein AM338_05550 ENOG4107QZW Altronate oxidoreductase AM338_05560 ENOG4105BZU Histidine kinase AM338_05565 ENOG4105M0C cytoplasmic protein AM338_05570 ENOG4105CSV Glutaminase AM338_05575 ENOG4105C26 Dehydrogenase AM338_05580 ENOG4105EGI Transcriptional regulator AM338_05600 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes AM338_05605 ENOG4108XW0 May be a transcriptional activator of genes involved in the multiple antibiotic resistance (Mar) phenotype. It can also activate genes such as sodA, zwf and micF AM338_05610 ENOG4106DNR multiple antibiotic resistance protein AM338_05615 ENOG4108594 Permease of the drug metabolite transporter AM338_05620 ENOG4105E5W Transporter AM338_05630 ENOG4105FSR swimming returnes to normal when residues 206-207 are both mutated to Ala. Overexpression also leads to a reduction in flagellar abundance and a 20-fold increase in c-di- GMP levels in vivo. Required for aminoglycoside-mediated induction of biofilm formation, it also plays a lesser role in biofilm production in response to other classes of translation inhibitors. The c-di-GMP produced by this enzyme up-regulates poly-GlcNAc production as well as the biofilm synthesis protein PgaD, although c-di-GMP is probably not the main inducing principle. Cyclic-di- GMP is a second messenger which controls cell surface-associated traits in bacteria AM338_05635 ENOG4108YDI single-species biofilm formation on inanimate substrate AM338_05640 ENOG4108WTK competence damage-inducible protein AM338_05645 ENOG4105DGW oligopeptidase A AM338_05655 ENOG4105EMU Dehydrogenase AM338_05660 ENOG4107XBN GntR Family Transcriptional Regulator AM338_05665 ENOG41061EV selenium-binding protein YdfZ AM338_05670 ENOG4105DEI Mannitol dehydrogenase AM338_05680 ENOG4105CPQ Dehydrogenase AM338_05685 ENOG4105CXK mandelate racemase muconate lactonizing AM338_05705 ENOG4108MK9 spermidine N(1)-acetyltransferase AM338_05715 ENOG4105KBG Protein of unknown function (DUF1161) AM338_05720 ENOG4107QY8 reductase AM338_05725 ENOG4105C3J Cysteine desulfurase AM338_05730 ENOG4105QAX Iron-sulfur AM338_05735 ENOG4107KGK dmso reductase anchor subunit AM338_05740 ENOG4108NEM leader-binding protein dmsD AM338_05750 ENOG4105EWW Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) AM338_05755 ENOG4105DAG ROK family AM338_05760 ENOG4106NZI LysR family Transcriptional regulator AM338_05765 ENOG4105D94 Major Facilitator Superfamily AM338_05785 ENOG4105CVW peptidase s1 and s6 chymotrypsin hap AM338_05805 ENOG4105DSF transport protein AM338_05810 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) AM338_05815 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) AM338_05820 ENOG4105C5D exported protein AM338_05830 ENOG4105D5Q Arginine ornithine antiporter AM338_05835 ENOG410642E Short chain dehydrogenase AM338_05840 ENOG4105RA2 Membrane AM338_05845 ENOG4107EXC regulatoR AM338_05850 ENOG4105JJR Histidine kinase AM338_05860 ENOG4105C9Q fumarate hydratase class II AM338_05865 ENOG4107GFK fumarate AM338_05870 ENOG4105EIP mannose-6-phosphate isomerase AM338_05875 ENOG4106J39 exported protein AM338_05880 ENOG4108QNI outer membrane porin protein AM338_05885 ENOG4105CT4 transporter AM338_05890 ENOG4105CNT hydrolase family 2 AM338_05895 ENOG4105XEA Tetr family transcriptional regulator AM338_05900 ENOG4107ZQV short-chain dehydrogenase reductase AM338_05905 ENOG4107P2S Transcriptional regulator AM338_05910 ENOG4105CI1 PTS System AM338_05915 ENOG4105C87 Aminotransferase class I and II AM338_05925 ENOG4105D9R oxidoreductase AM338_05930 ENOG4106C6R beta-lactam resistance protein AM338_05940 ENOG4105QZ5 OriC-binding nucleoid-associated protein AM338_05945 ENOG4105M9B inner membrane protein ydgK AM338_05970 ENOG4108UQQ Electron transport complex AM338_05980 ENOG4105CSM endonuclease III AM338_05990 ENOG4105DUX Transporter AM338_05995 ENOG4108K3A Glutathione S-transferase AM338_06000 ENOG4107XGF functions in a salvage pathway. Uses pyridoxamine (By similarity) AM338_06015 ENOG410642K Lysozyme inhibitor AM338_06025 ENOG4108XTF Outer Membrane Lipoprotein AM338_06040 ENOG4105Y49 secretion protein, HlyD family AM338_06045 ENOG4105DSW Fusaric acid resistance protein AM338_06050 ENOG4108Z7T Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) AM338_06055 ENOG4107RGM aldo keto reductase AM338_06060 ENOG4105XZD Fe-S protein AM338_06065 ENOG4108WUH Transcriptional regulator, TetR family AM338_06070 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase AM338_06075 ENOG4108UYE Lactoylglutathione lyase AM338_06080 ENOG4105DH5 Responsible for the end-turnover of tRNA specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis (By similarity) AM338_06085 ENOG4107QRT dEAD DEAH box helicase AM338_06090 ENOG4105M2J Glutaredoxin AM338_06095 ENOG4105K4H Nlp p60 protein AM338_06100 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) AM338_06105 ENOG4105F27 Major Facilitator AM338_06125 ENOG4105F52 Transcriptional regulator AM338_06130 ENOG4105CZQ inner membrane transport protein YdhC AM338_06135 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase AM338_06140 ENOG4108R6K riboflavin synthase, subunit alpha AM338_06165 ENOG4105N0V mono-oxygenase ydhR AM338_06170 ENOG4108KTU conserved protein with FAD NAD(P)-binding domain AM338_06175 ENOG4108Y7C Conserved Protein AM338_06180 ENOG4108NWD Cytochrome AM338_06185 ENOG4108393 oxidoreductase Fe-S subunit AM338_06190 ENOG4105JVW AM338_06195 ENOG4105WE2 aldehyde ferredoxin oxidoreductase AM338_06200 ENOG4108PU5 4fe-4S ferredoxin, iron-sulfur binding domain protein AM338_06205 ENOG4105RFR Protein of unknown function (DUF2767) AM338_06210 ENOG4105CA9 Pyruvate kinase AM338_06215 ENOG4105KMX major outer membrane lipoprotein AM338_06220 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein AM338_06235 ENOG4105JRK feS assembly protein SufD AM338_06240 ENOG4105C3K feS assembly ATPase SufC AM338_06245 ENOG4105DIW FeS assembly protein SUFB AM338_06250 ENOG4108Z4V iron-sulfur cluster assembly AM338_06255 ENOG410671Z uncharacterized protein ydiH AM338_06260 ENOG4105KA0 thioesterase Superfamily protein AM338_06265 ENOG4105CQB FAD linked oxidase domain protein AM338_06275 ENOG4105IPI Membrane AM338_06285 ENOG4105SUA Ydil protein AM338_06290 ENOG4105EMV Major Facilitator AM338_06295 ENOG4105EMV Major Facilitator AM338_06310 ENOG4107R0K CoA transferase having broad substrate specificity for short-chain acyl-CoA thioesters with the activity decreasing when the length of the carboxylic acid chain exceeds four carbons (By similarity) AM338_06315 ENOG4105C1G acyl-Coa dehydrogenase AM338_06320 ENOG4105W4W Transcriptional regulator AM338_06330 ENOG4105CV7 Electron transfer flavoprotein AM338_06335 ENOG4105C10 Electron transfer flavoprotein AM338_06340 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase AM338_06345 ENOG41090P5 ferredoxin-like protein AM338_06350 ENOG4105CEY Amp-dependent synthetase and ligase AM338_06355 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) AM338_06370 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) AM338_06375 ENOG4106EDX Hemin uptake protein AM338_06385 ENOG4108TC0 Diguanylate phosphodiesterase AM338_06390 ENOG4108QBX (LipO)protein AM338_06400 ENOG4108V06 Glutathione peroxidase AM338_06415 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) AM338_06425 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) AM338_06430 ENOG41082NX 50s ribosomal protein l35 AM338_06460 ENOG4108NE3 Salt-induced outer membrane protein AM338_06465 ENOG4105DE4 1-phosphofructokinase AM338_06470 ENOG4105P10 Uncharacterized protein ydiZ AM338_06475 ENOG4105FGM Fructosamine kinase AM338_06480 ENOG4107PN8 YfeABCD locus regulator AM338_06485 ENOG4107UW8 HAD-superfamily hydrolase subfamily IA variant 3 AM338_06490 ENOG4107K5X Membrane-bound metal-dependent hydrolase AM338_06495 ENOG4108ETY sodium dicarboxylate symporter AM338_06510 ENOG4105CH6 catalase AM338_06520 ENOG4105F8D glycoside hydrolase family 4 AM338_06525 ENOG4105EZV Transcriptional regulator AM338_06530 ENOG4105VCP PTS System AM338_06535 ENOG4105CK1 PTS System AM338_06540 ENOG4105VZJ PTS System AM338_06550 ENOG4105KKI DNA-binding transcriptional activator OsmE AM338_06560 ENOG4105DKD Incises the DNA at the 3' side of a lesion during nucleotide excision repair. Incises the DNA farther away from the lesion than UvrC. Not able to incise the 5' site of a lesion. When a lesion remains because UvrC is not able to induce the 3' incision, Cho incises the DNA. Then UvrC makes the 5' incision. The combined action of Cho and UvrC broadens the substrate range of nucleotide excision repair (By similarity) AM338_06570 ENOG4108SPG Periplasmic Protein AM338_06590 ENOG4105F4X arginine AM338_06605 ENOG4105CGK Exodeoxyribonuclease III AM338_06610 ENOG4108RSN SNARE associated Golgi AM338_06615 ENOG4108KCW iron-sulfur cluster binding AM338_06620 ENOG4108N5C SNARE associated Golgi protein-related protein AM338_06625 ENOG4107ZN8 Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) AM338_06630 ENOG4105VNH ABC transporter solute-binding protein AM338_06635 ENOG4105CXZ ABC transporter, permease AM338_06640 ENOG4108VGW abc transporter atp-binding protein AM338_06645 ENOG4107RM6 sulfurtransferase AM338_06650 ENOG4108T9J Cdp-alcohol phosphatidyltransferase AM338_06655 ENOG4105M6F mutator MutT protein AM338_06660 ENOG4105MTM Protein of unknown function (DUF1496) AM338_06665 ENOG4105D82 Glutamate dehydrogenase AM338_06670 ENOG41065FB inner membrane protein ynji AM338_06675 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) AM338_06690 ENOG41069NU Nitroreductase AM338_06700 ENOG4105D07 Signal peptide peptidase, SppA AM338_06705 ENOG4105HDK L-asparaginase AM338_06710 ENOG4108RWI nicotinamidase AM338_06715 ENOG4108KUU Inner membrane metabolite transport protein ydjE AM338_06720 ENOG4105E98 transcriptional regulator DeoR family AM338_06725 ENOG4105CPC Aldo Keto reductase AM338_06730 ENOG4107UH8 sugar kinase AM338_06735 ENOG4105D2N Aldolase AM338_06740 ENOG4105CPQ Dehydrogenase AM338_06745 ENOG4107TE1 transport protein AM338_06750 ENOG4105CPQ Dehydrogenase AM338_06755 ENOG4105VUT cytoplasmic protein AM338_06765 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase AM338_06770 ENOG4105DSB aldose 1-epimerase AM338_06775 ENOG4105CV8 reductase AM338_06780 ENOG4105GNX MltA-interacting MipA family protein AM338_06785 ENOG4105CYN Serine protein kinase AM338_06795 ENOG4106KTS Inner membrane protein yeaI AM338_06800 ENOG4108KHP Diguanylate cyclase AM338_06805 ENOG4108KXH Ybak prolyl-tRNA synthetase associated AM338_06820 ENOG4105R1U AraC Family Transcriptional Regulator AM338_06825 ENOG4105DJ2 Major Facilitator Superfamily AM338_06830 ENOG4105K78 MarR family Transcriptional regulator AM338_06835 ENOG4105UCG Domain of unknown function (DUF333) AM338_06840 ENOG410620I Diguanylate cyclase AM338_06845 ENOG4106G4W AM338_06855 ENOG4105Y3U Transglycosylase-associated protein AM338_06860 ENOG4105YP6 Domain of unknown function (DUF1869) AM338_06865 ENOG4108YS1 cytoplasmic protein AM338_06875 ENOG4105EJC lysr family transcriptional regulator AM338_06880 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) AM338_06885 ENOG4105C94 Transporter AM338_06890 ENOG4105DVW rieske (2Fe-2S) AM338_06895 ENOG4105E3J oxidoreductase AM338_06900 ENOG4105ZIE Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity) AM338_06905 ENOG4105CEY Amp-dependent synthetase and ligase AM338_06910 ENOG4105Y4Z Outer Membrane Lipoprotein AM338_06915 ENOG41072GX Peptidase M22 Glycoprotease AM338_06920 ENOG4105DVT helicase AM338_06925 ENOG4105M4H endoribonuclease L-psp AM338_06930 ENOG4105V2F Uncharacterized protein yoac AM338_06940 ENOG4105CRQ synthase (Component I) AM338_06950 ENOG4105EJQ L-serine dehydratase AM338_06960 ENOG4105EE5 Membrane protein terC AM338_06975 ENOG4108EQA pts system AM338_06980 ENOG4105ETZ PTS System AM338_06985 ENOG4105F3R pts system mannose fructose sorbose family iid AM338_07005 ENOG4105DHI Methyltransferase AM338_07010 ENOG4105VEQ Cold shock protein AM338_07015 ENOG410610J Protein of unknown function (DUF2627) AM338_07025 ENOG4105Q3Y exported protein AM338_07035 ENOG4105TIK AM338_07040 ENOG4105J4Q Transcriptional regulator AM338_07045 ENOG4105C0R drug resistance transporter emrb qaca subfamily AM338_07055 ENOG4105CN1 protease AM338_07065 ENOG4108ZGC gaf domain protein AM338_07070 ENOG4105H2K paraquat-inducible protein a AM338_07075 ENOG4105DY2 Paraquat-inducible protein b AM338_07085 ENOG4105WT8 Protein of unknown function (DUF1480) AM338_07090 ENOG4105UVW uncharacterized protein yebW AM338_07095 ENOG4108R1E Serine threonine protein phosphatase 1 AM338_07100 ENOG4105NKT exported protein AM338_07105 ENOG4108PNC copper resistance AM338_07110 ENOG4105FXM Copper resistance protein AM338_07115 ENOG4105MPK DNA polymerase III subunit theta AM338_07120 ENOG4108YGA nitrilase cyanide hydratase and apolipoprotein n-acyltransferase AM338_07125 ENOG4105UMD exodeoxyribonuclease X AM338_07130 ENOG4105CUG Oligopeptidase b AM338_07135 ENOG4108Q2J Inner membrane protein YebE AM338_07140 ENOG4105RSZ secreted protein AM338_07145 ENOG4105X2V dna damage-inducible protein AM338_07155 ENOG4108UHU Aldolase AM338_07160 ENOG4105C01 Dihydroxy-acid dehydratase AM338_07165 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase AM338_07170 ENOG4106KNT transcriptional regulator AM338_07175 ENOG4105CA9 Pyruvate kinase AM338_07180 ENOG4105NWR lipid A biosynthesis (Kdo)2-(Lauroyl)-lipid IVA acyltransferase AM338_07185 ENOG4105DR5 peptidase AM338_07190 ENOG4105NXV High-affinity zinc uptake system protein AM338_07195 ENOG4105FDK ABC transporter AM338_07200 ENOG4105FAV ABC, transporter AM338_07220 ENOG4107S01 Repressor protein MetJ AM338_07230 ENOG4105CDY transcriptional regulatory protein AM338_07235 ENOG4108TIT dATP pyrophosphohydrolase AM338_07245 ENOG4105D3W isochorismatase AM338_07250 ENOG41081XQ Conserved Protein AM338_07255 ENOG4105WJG Glutathione AM338_07270 ENOG4107QY8 reductase AM338_07275 ENOG4105CUW cytochrome C-TYPE protein AM338_07285 ENOG4106ZCM YecM protein AM338_07305 ENOG4105W13 flagellar protein AM338_07310 ENOG4105D7B Flagellar biosynthesis protein flha AM338_07315 ENOG4105D00 flagellar biosynthetic protein flhB AM338_07320 ENOG4108KCC Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P) (By similarity) AM338_07325 ENOG4108VYJ response regulator receiver protein AM338_07330 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) AM338_07335 ENOG4105BZU Histidine kinase AM338_07340 ENOG4105C8Q Methyl-accepting chemotaxis AM338_07345 ENOG4105C8Q Methyl-accepting chemotaxis AM338_07350 ENOG4108V3W Chemotaxis protein, CheW AM338_07355 ENOG4105CBS Chea signal transduction histidine kinase AM338_07360 ENOG4105ER2 Ompa motb domain protein AM338_07365 ENOG4107RD7 Flagellar Motor Protein, MotA AM338_07370 ENOG4106CIA Functions in complex with FlhD as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region AM338_07380 ENOG4108VA4 Universal stress protein AM338_07390 ENOG4108K4C ec 3.1.3.12 AM338_07395 ENOG4105CNN ABC, transporter AM338_07400 ENOG4105C2J ABC transporter AM338_07405 ENOG4105DMK Periplasmic binding protein LacI transcriptional regulator AM338_07415 ENOG4108UEC Ferritin-like protein AM338_07420 ENOG4105N4N Protein of unknown function (DUF2766) AM338_07430 ENOG4105P23 (LipO)protein AM338_07435 ENOG41090A1 ferritin AM338_07440 ENOG4105VVZ metal-binding protein AM338_07445 ENOG4105E0U tyrosine-specific transport protein AM338_07450 ENOG4106RHG Yeca family AM338_07470 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase AM338_07480 ENOG4105WH1 Two component transcriptional regulator luxr family AM338_07490 ENOG4105XVG cytoplasmic protein AM338_07495 ENOG4105VJY transcriptional regulator AM338_07500 ENOG4105CDA abc transporter atp-binding protein AM338_07505 ENOG4105E5Q amino acid AbC transporter AM338_07515 ENOG4105EAB amino acid AbC transporter AM338_07520 ENOG4108M9K flagella biosynthesis protein FliZ AM338_07525 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AM338_07530 ENOG4105I03 Flagellin AM338_07540 ENOG4105DTS flagellar hook-associated AM338_07545 ENOG4105MQ3 flagellar protein FliS AM338_07550 ENOG4105YXP it directly binds FlhC, thus inhibiting the binding of the FlhC FlhD complex to class 2 promoters, resulting in decreased expression of class 2 flagellar operons. As a chaperone, effects FliD transition to the membrane by preventing its premature polymerization, and by directing it to the export apparatus (By similarity) AM338_07555 ENOG4105E5K Alpha-amylase AM338_07560 ENOG4108W9D (LipO)protein AM338_07570 ENOG41066VF YeeE YedE family protein AM338_07575 ENOG4105KSU Redox protein AM338_07580 ENOG4108RAV Conserved protein AM338_07605 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) AM338_07610 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) AM338_07615 ENOG41090PJ Flagellar assembly protein AM338_07620 ENOG4108JIR Flagellum-specific ATP synthase AM338_07625 ENOG4105GSA Flagellar export protein flij AM338_07630 ENOG4105WF4 Flagellar hook-length control protein AM338_07635 ENOG4107ZI8 flagellar basal body-associated protein flil AM338_07640 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) AM338_07645 ENOG4105DD5 Flagellar motor switch protein AM338_07650 ENOG4105K0P flagellar biosynthesis protein AM338_07655 ENOG4105CN7 Flagellar biosynthetic protein FliP AM338_07660 ENOG4105VS8 Flagellar biosynthetic protein fliq AM338_07665 ENOG4105D19 Role in flagellar biosynthesis (By similarity) AM338_07670 ENOG4107TKS colanic acid capsular biosynthesis activation protein A AM338_07685 ENOG4105YX3 cellular response to acidity AM338_07705 ENOG4105VNZ cytoplasmic protein AM338_07710 ENOG4105CKW Inner membrane protein yedI AM338_07715 ENOG4105FDR Membrane AM338_07720 ENOG41090BB DNA mismatch endonuclease (vsr) AM338_07725 ENOG4105DVF Cytosine-specific methyltransferase AM338_07730 ENOG4105EST Metal Dependent Phosphohydrolase AM338_07735 ENOG4105Y0K Inner membrane protein YedR AM338_07740 ENOG4105ZIT Porin Gram-negative type AM338_07755 ENOG4107ZY3 Histidine kinase AM338_07760 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AM338_07765 ENOG4105VT2 5-hydroxyisourate hydrolase AM338_07780 ENOG4108MEK Metal-binding protein YodA AM338_07785 ENOG4108VKM cytochrome b561 AM338_07810 ENOG4105TNG K13735 adhesin invasin AM338_07820 ENOG4105CSH Transporter AM338_07825 ENOG4105FYV Amp nucleosidase AM338_07830 ENOG4105CDY transcriptional regulatory protein AM338_07845 ENOG4105UQX Mate efflux family protein AM338_07855 ENOG4107R11 Transcriptional regulator AM338_07860 ENOG4106P55 Transcriptional regulator AM338_07880 ENOG4105EYM Major Facilitator superfamily AM338_07885 ENOG4105BZ1 (ABC) transporter AM338_07900 ENOG4105C0W non-ribosomal peptide synthetase AM338_07920 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase AM338_07925 ENOG4107ZSV Receptor AM338_08000 ENOG4108PCE TRANSFER protein AM338_08055 ENOG4105W5Q DNA repair protein (RadC AM338_08135 ENOG4108PXI ErfK YbiS YcfS YnhG AM338_08150 ENOG4108YZT Adenosylcobinamide kinase AM338_08175 ENOG4106H6R UPF0380 protein AM338_08180 ENOG4105MFG Antirestriction protein AM338_08185 ENOG4108YGG dna repair protein AM338_08190 ENOG4106WJE Protein of unknown function (DUF987) AM338_08195 ENOG4105MAW Antitoxin component of a toxin-antitoxin (TA) module. Labile antitoxin that counteracts the effect of the CbtA (YeeV) toxin. It does not bind to the cognate toxin but instead binds to MreB and FtsZ (the toxin targets), enhancing their polymerization by forming higher-order bundles AM338_08225 ENOG4105DR8 Membrane AM338_08230 ENOG4108S5C Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell (By similarity) AM338_08240 ENOG4105DZ1 carboxypeptidase AM338_08245 ENOG4105CJB Exodeoxyribonuclease I AM338_08255 ENOG4105CUC YeeE YedE family protein AM338_08260 ENOG4105CUB amino acid AM338_08265 ENOG4105EQ1 Transcriptional regulator AM338_08270 ENOG4108535 NAD dependent epimerase/dehydratase family AM338_08275 ENOG4105KRQ Addiction module toxin, Txe YoeB family AM338_08280 ENOG4105VTW prevent-host-death family AM338_08300 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) AM338_08310 ENOG4105ECC imidazole-glycerol-phosphate dehydratase AM338_08315 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) AM338_08330 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase AM338_08340 ENOG4107UU3 sucrose-phosphate synthase (EC 2.4.1.14) AM338_08345 ENOG4108TJN glycosyl transferase group 1 AM338_08355 ENOG4105EY8 ABC transporter AM338_08385 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase AM338_08390 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase AM338_08400 ENOG4105C1B dTDP-glucose 4-6-dehydratase AM338_08415 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) AM338_08450 ENOG4108KBE Glycosyl transferase, family 2 AM338_08455 ENOG4105D3Q Sugar transferase AM338_08470 ENOG4105DAY polysaccharide export protein AM338_08475 ENOG4108MRJ AM338_08485 ENOG4105MH5 phosphoesterase PA-phosphatase related protein AM338_08495 ENOG4105EE5 Membrane protein terC AM338_08510 ENOG4108GAE asmA family AM338_08520 ENOG4105DBI uridine monophosphokinase AM338_08525 ENOG4105BZU Histidine kinase AM338_08530 ENOG4105D03 DNA-3-methyladenine glycosylase II AM338_08535 ENOG4105R8A Heat shock protein AM338_08540 ENOG4106E1W protein with protein kinase and helix-hairpin-helix DNA-binding AM338_08545 ENOG4105ZD5 Uncharacterized protein conserved in bacteria (DUF2314) AM338_08550 ENOG4105UM3 Inherit from NOG: serine threonine phosphoprotein phosphatase AM338_08555 ENOG4108M24 von Willebrand factor, type A AM338_08585 ENOG4105EB3 Histidine kinase AM338_08590 ENOG4105E3W Two component transcriptional regulator (Winged helix family AM338_08595 ENOG4105KWI UPF0339 protein AM338_08600 ENOG4105CFP Peptidase U32 AM338_08610 ENOG41076Z6 Uncharacterized protein yegR AM338_08620 ENOG4107UW8 HAD-superfamily hydrolase subfamily IA variant 3 AM338_08625 ENOG4105IE8 Alpha-ketoglutarate permease AM338_08630 ENOG4105CMG Carbohydrate kinase AM338_08635 ENOG4105DEI Mannitol dehydrogenase AM338_08655 ENOG4105EF1 ribulokinase AM338_08660 ENOG4105IE8 Alpha-ketoglutarate permease AM338_08665 ENOG4105EIE fructose-bisphosphate aldolase AM338_08670 ENOG4105EAA nucleoside AM338_08675 ENOG4108KD5 ADP-ribosylation crystallin J1 AM338_08680 ENOG4108TFM Kinase, PfkB family AM338_08685 ENOG4105FDP GntR family transcriptional regulator AM338_08690 ENOG4108UQ1 hydrolase, family 25 AM338_08695 ENOG4105DWF phosphomethylpyrimidine kinase AM338_08715 ENOG4108Z1S Influences nickel and cobalt homeostasis. May act by modulating RcnA-mediated export of these ions to avoid excess efflux. Not involved in nickel import and does not bind nickel or cobalt ions directly AM338_08720 ENOG410662B Type-1 fimbrial protein AM338_08725 ENOG4105CW0 outer membrane usher protein AM338_08730 ENOG4108MQF Chaperone AM338_08735 ENOG41063W2 Fimbrial protein AM338_08745 ENOG41067AK Protein of unknown function (DUF2574) AM338_08750 ENOG4105D1F ATP-binding protein AM338_08765 ENOG4108KDT Molybdate metabolism regulator AM338_08775 ENOG4105KKX ATPase associated with various cellular activities aaa_5 AM338_08780 ENOG4105RD5 AM338_08785 ENOG4105DEG Vwa containing coxe family protein AM338_08790 ENOG410903U zinc ion binding AM338_08795 ENOG4108YCW (LipO)protein AM338_08800 ENOG4108W15 Protein of unknown function (DUF1456) AM338_08805 ENOG4108NEV two component transcriptional regulator, LytTR family AM338_08810 ENOG4108HRK Histidine kinase AM338_08815 ENOG4108XDN Transcriptional regulator AM338_08825 ENOG4105WJV Binding-protein-dependent transport systems, inner membrane component AM338_08830 ENOG4108IJ8 ABC transporter AM338_08835 ENOG4107T5X Binding-protein-dependent transport systems, inner membrane component AM338_08840 ENOG4107SI7 Substrate-binding region of abc-type glycine betaine transport system AM338_08845 ENOG4107QK4 glycoside hydrolase, family 3 domain protein AM338_08850 ENOG4105CXG d-lactate dehydrogenase AM338_08855 ENOG41061WM D-Alanyl-D-Alanine AM338_08860 ENOG41069YE inner membrane protein yohC AM338_08865 ENOG4105KHU inner membrane protein YohD AM338_08870 ENOG4105H9W Short-chain dehydrogenase reductase Sdr AM338_08875 ENOG4105ETP RND efflux system, outer membrane lipoprotein AM338_08895 ENOG4105FBT Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity) AM338_08905 ENOG41067MG lrgb family AM338_08915 ENOG4107GZ4 SanA protein AM338_08920 ENOG4105Y9N Membrane AM338_08925 ENOG4105BZ8 glutamate synthase AM338_08930 ENOG4107SJI Dehydrogenase AM338_08935 ENOG4108HWV )-transporter AM338_08940 ENOG4105C2J ABC transporter AM338_08945 ENOG4105EMA Periplasmic binding protein LacI transcriptional regulator AM338_08950 ENOG41060NJ transcriptional regulator AM338_08960 ENOG4105DHF Membrane AM338_08980 ENOG4105C4W S-formylglutathione hydrolase AM338_08985 ENOG4105D05 Receptor AM338_08995 ENOG4108IQI permease AM338_09005 ENOG4105DUM transcriptional regulator, lysR family AM338_09010 ENOG4105HMI Membrane AM338_09015 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) AM338_09020 ENOG4105DD7 kinase (PfkB family AM338_09025 ENOG4105D9N nucleoside AM338_09035 ENOG4108Y4K DNA-binding transcriptional activator AM338_09040 ENOG4105D9N nucleoside AM338_09045 ENOG4105D53 Catalyzes the hydrolysis of pseudouridine 5'-phosphate (PsiMP) to ribose 5-phosphate and uracil (By similarity) AM338_09050 ENOG4105DD7 kinase (PfkB family AM338_09055 ENOG4105DM4 PTS System AM338_09060 ENOG4105DE4 1-phosphofructokinase AM338_09065 ENOG4105DTZ bifunctional PTS system fructose-specific transporter subunit IIA HPr protein AM338_09070 ENOG4105S8Q sugar efflux transporter AM338_09075 ENOG4105KRS Proteinase inhibitor AM338_09085 ENOG4105DEI Mannitol dehydrogenase AM338_09090 ENOG4105CKI cobalamin synthesis protein AM338_09095 ENOG41076MN Phosphoesterase, PA-phosphatase related AM338_09100 ENOG4107TT5 NLP P60 protein AM338_09105 ENOG4105CXC rtn protein AM338_09110 ENOG4105E43 Extracellular solute-binding protein, family 5 AM338_09115 ENOG4108I5X binding-protein-dependent transport systems inner membrane Component AM338_09120 ENOG4108IYQ Binding-protein-dependent transport systems inner membrane component AM338_09125 ENOG4108JQ5 ABC transporter AM338_09130 ENOG4105HG6 AM338_09140 ENOG4105C2C drug resistance transporter, Bcr CflA AM338_09145 ENOG4105I08 Pseudouridine synthase AM338_09155 ENOG4105CFI type iii restriction protein res subunit AM338_09175 ENOG4105E68 Sulfatase AM338_09190 ENOG4108MGN ATP-binding component of a transport system AM338_09200 ENOG4105WH1 Two component transcriptional regulator luxr family AM338_09205 ENOG4105KWW Biogenesis protein AM338_09210 ENOG4107QX9 Thiol disulfide interChange protein AM338_09215 ENOG4105DA4 cytochrome c-type biogenesis protein AM338_09225 ENOG4105X3C heme exporter protein AM338_09230 ENOG41060IM Heme exporter protein AM338_09235 ENOG4105CA5 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes (By similarity) AM338_09240 ENOG4107EV4 once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system (By similarity) AM338_09245 ENOG4105CUW cytochrome C-TYPE protein AM338_09250 ENOG4108ZMS Electron transfer subunit of the periplasmic nitrate reductase complex NapAB (By similarity) AM338_09255 ENOG4105GXZ Ferredoxin-type protein NapH AM338_09260 ENOG4108BGM Quinol dehydrogenase periplasmic component AM338_09270 ENOG41061Q0 Assembly protein for periplasmic nitrate reductase AM338_09275 ENOG4108ZNS ferredoxin-type protein NapF AM338_09295 ENOG4105IBP Cyclic peptide transporter AM338_09300 ENOG4105CF1 Alkylated DNA repair protein AM338_09305 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) AM338_09310 ENOG4105CJ2 (LipO)protein AM338_09315 ENOG4105FCK Membrane AM338_09330 ENOG4105E3G Phosphotransfer intermediate protein in two-component regulatory system with RcsBC AM338_09335 ENOG41068CG regulatoR AM338_09340 ENOG4105BZU Histidine kinase AM338_09345 ENOG4105BZU Histidine kinase AM338_09350 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family AM338_09355 ENOG4107QP7 CoA-transferase subunit A AM338_09360 ENOG4107QNJ CoA-transferase subunit B AM338_09365 ENOG4105CRW Short chain fatty acid transporter AM338_09370 ENOG4105CHU acetyl-coa acetyltransferase AM338_09375 ENOG4105EDV vault protein AM338_09380 ENOG41081SK signal peptide protein AM338_09385 ENOG4107S52 alpha-2-macroglobulin domain protein AM338_09390 ENOG4108QJJ Protein of unknown function (DUF1175) AM338_09395 ENOG4107FKF Uncharacterized protein conserved in bacteria (DUF2138) AM338_09400 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) AM338_09410 ENOG4107GHC outer membrane autotransporter AM338_09420 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) AM338_09425 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) AM338_09430 ENOG4105XPH Ferredoxin AM338_09435 ENOG4105FQR PH-inducible protein involved in stress response AM338_09440 ENOG4107R11 Transcriptional regulator AM338_09445 ENOG4106MZZ glycerophosphoryl diester phosphodiesterase AM338_09450 ENOG4105CXY transporter AM338_09455 ENOG4107R5Y anaerobic glycerol-3-phosphate dehydrogenase, subunit A AM338_09465 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) AM338_09470 ENOG4105DNE Transposase AM338_09485 ENOG4105CSP Major Facilitator Superfamily AM338_09495 ENOG4107258 Transcriptional regulator AM338_09500 ENOG4107258 Transcriptional regulator AM338_09510 ENOG4108UII YfaZ family AM338_09540 ENOG4105F73 Catalyzes the deformylation of 4-deoxy-4-formamido-L- arabinose-phosphoundecaprenol to 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity) AM338_09545 ENOG4105SA9 Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity) AM338_09555 ENOG4105U65 Translocates 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol (alpha-L-Ara4N-phosphoundecaprenol) from the cytoplasmic to the periplasmic side of the inner membrane (By similarity) AM338_09560 ENOG4106GZG polymyxin resistance protein B AM338_09565 ENOG4105CEY Amp-dependent synthetase and ligase AM338_09575 ENOG4108IPT Naphthoate synthase AM338_09590 ENOG4105E4F Isochorismate synthase AM338_09595 ENOG4105TNS Conserved Protein AM338_09600 ENOG4107YB6 acetyltransferase, (GNAT) family AM338_09610 ENOG4105Z6G Protease that can act as an efficient and specific deubiquitinating enzyme in vitro. Does not possess desumoylating and deneddylating activities. The physiological substrate is AM338_09615 ENOG4105CP2 von willebrand factor, type a AM338_09620 ENOG4107VAM peptidase, m28 AM338_09625 ENOG4105GDX Domain of unknown function (DUF1877) AM338_09630 ENOG4105ZD8 AM338_09635 ENOG4106EES AM338_09640 ENOG4106HDC AM338_09650 ENOG4105C8S subunit m AM338_09655 ENOG4105D65 subunit l AM338_09660 ENOG41080EA NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) AM338_09665 ENOG4107UFS subunit j AM338_09670 ENOG4105P3U NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) AM338_09680 ENOG4107R0R NADH dehydrogenase subunit g AM338_09685 ENOG4107QIZ NADH dehydrogenase AM338_09690 ENOG4105GKE subunit e AM338_09695 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) AM338_09710 ENOG4107NQ8 LysR family Transcriptional regulator AM338_09720 ENOG4105CHM Aminotransferase AM338_09730 ENOG4107QWE )-transporter AM338_09735 ENOG4105EVE HAD-superfamily hydrolase subfamily IA variant 3 AM338_09750 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) AM338_09755 ENOG4105C6K Malic enzyme AM338_09760 ENOG4105CSX c4-dicarboxylate anaerobic carrier AM338_09765 ENOG4105PTV Nudix Hydrolase AM338_09770 ENOG4108RE9 Phosphodiesterase AM338_09775 ENOG4108SHQ Glutathione S-transferase AM338_09780 ENOG4105CYM Glutathione S-transferase AM338_09785 ENOG4105KKP D-erythro-7,8-dihydroneopterin triphosphate 2'-epimerase AM338_09790 ENOG4105ECP epimerase AM338_09795 ENOG4105DNE Transposase AM338_09800 ENOG4108JEH abc transporter atp-binding protein AM338_09805 ENOG4106YG3 ABC transporter AM338_09810 ENOG4105DSP amino acid AbC transporter AM338_09815 ENOG4105E89 ABC transporter AM338_09820 ENOG4105E89 ABC transporter AM338_09825 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase AM338_09830 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase AM338_09835 ENOG4105E96 Colicin v production protein AM338_09840 ENOG4108S3P Sporulation domain protein AM338_09845 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase AM338_09855 ENOG4105DQR SNARE associated Golgi AM338_09865 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) AM338_09870 ENOG4105CJ0 Catalyzes the oxidation of erythronate-4-phosphate to 3- hydroxy-2-oxo-4-phosphonooxybutanoate (By similarity) AM338_09875 ENOG4106WZ1 flagella biosynthesis regulator AM338_09880 ENOG4105F9N Major Facilitator Superfamily AM338_09890 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) AM338_09895 ENOG4105CWG Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity) AM338_09900 ENOG4105MH2 YfcL protein AM338_09905 ENOG4108BPE -transporting atpase AM338_09910 ENOG4105EJ9 Membrane AM338_09925 ENOG4105C76 Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity) AM338_09940 ENOG4105US4 fimbrial-like protein yfcP AM338_09945 ENOG4105UGQ Fimbrial AM338_09950 ENOG4105NEV Fimbrial AM338_09955 ENOG4108FZ9 Chaperone AM338_09960 ENOG4106PG1 outer membrane usher protein AM338_09970 ENOG4108BY2 phosphohistidine phosphatase AM338_09985 ENOG4105KZW UPF0381 protein AM338_09995 ENOG4105CKF membrane protein involved in aromatic hydrocarbon degradation AM338_10010 ENOG410903C (LipO)protein AM338_10020 ENOG4105S64 Formate nitrite transporter AM338_10030 ENOG4105U0F oligosaccharide H symporter, major facilitator superfamily (MFS) AM338_10035 ENOG4105D7K pfkb domain protein AM338_10040 ENOG4108HKT sucrose-6-phosphate hydrolase AM338_10045 ENOG4106NDP Transcriptional regulator AM338_10060 ENOG4105C0R drug resistance transporter emrb qaca subfamily AM338_10065 ENOG4105CW7 secretion protein, HlyD family AM338_10070 ENOG4108WQH regulatoR AM338_10075 ENOG4105BZU Histidine kinase AM338_10080 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F AM338_10085 ENOG4108N2Y auxin Efflux AM338_10090 ENOG4105CFN oxalyl-CoA decarboxylase AM338_10100 ENOG4108V08 YfdX protein AM338_10110 ENOG4105W9M Membrane AM338_10115 ENOG4105D1S lipid A biosynthesis AM338_10120 ENOG4105CHM Aminotransferase AM338_10125 ENOG4108HRK Histidine kinase AM338_10130 ENOG4105DY9 regulatoR AM338_10140 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) AM338_10145 ENOG4105CN9 Peptidase m42 family protein AM338_10150 ENOG4105DC7 peptidase M24 AM338_10155 ENOG410863U PTS System AM338_10160 ENOG4105R6B The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane (By similarity) AM338_10170 ENOG4105VCT ion-transport protein YfeO AM338_10175 ENOG4109076 Conserved Protein AM338_10185 ENOG4105D9N nucleoside AM338_10190 ENOG4108SER Transposase AM338_10195 ENOG4108KMM Diguanylate cyclase AM338_10210 ENOG4105HZG regulatoR AM338_10215 ENOG4105GXM Putative transcription regulator (DUF1323) AM338_10245 ENOG4105CN8 Transcriptional regulator AM338_10255 ENOG4105EAA nucleoside AM338_10260 ENOG4107U5R The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity) AM338_10265 ENOG4108NFH Sugar hydrolase AM338_10270 ENOG4108M0I Transcriptional regulator AM338_10275 ENOG4105DHU Bile acid AM338_10280 ENOG4105VRT cytoplasmic protein AM338_10285 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) AM338_10300 ENOG4105C6T cysteine synthase AM338_10305 ENOG4105KZ7 phosphocarrier protein hpr AM338_10310 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) AM338_10315 ENOG4105C5Y PTS System AM338_10325 ENOG4105M0Y AM338_10330 ENOG4105WEC Molybdate metabolism regulator AM338_10335 ENOG4105C6T cysteine synthase AM338_10340 ENOG4108IJ6 ABC transporter AM338_10345 ENOG4105ECW sulfate abc transporter AM338_10350 ENOG4108I5D sulfate abc transporter AM338_10355 ENOG4108J2H Sulfate ABC transporter periplasmic sulfate-binding protein AM338_10365 ENOG4105I7Z Short-chain dehydrogenase reductase Sdr AM338_10380 ENOG4105C5Y PTS System AM338_10385 ENOG4107S1E Beta-lactamase AM338_10390 ENOG4105EZR dyp-type peroxidase family protein AM338_10395 ENOG4105E7K (LipO)protein AM338_10400 ENOG4105QZU Inner membrane protein YfeZ AM338_10405 ENOG4108R6G acetyltransferase AM338_10410 ENOG4108KNB n-acetylmuramoyl-l-alanine amidase AM338_10420 ENOG4108K3Z AraC family transcriptional regulator AM338_10425 ENOG4108X49 Ethanolamine utilization protein EutK AM338_10430 ENOG4106D67 ethanolamine utilization protein AM338_10440 ENOG4105CPD ethanolamine ammonia-lyase AM338_10445 ENOG4105DYY Reactivating factor for ethanolamine ammonia lyase AM338_10450 ENOG4105ENY Ethanolamine utilization protein eutH AM338_10455 ENOG4105C0A alcohol dehydrogenase AM338_10460 ENOG4107RWI ethanolamine utilization protein eutJ AM338_10465 ENOG4108EKI Dehydrogenase AM338_10470 ENOG4105WVM ethanolamine utilization protein EutN carboxysome structural protein Ccml AM338_10475 ENOG4105KNY Microcompartments protein AM338_10480 ENOG4107WUY phosphate acetyltransferase AM338_10485 ENOG4108PFF ethanolamine utilization cobalamin adenosyltransferase AM338_10490 ENOG4105NDK ethanolamine utilization protein AM338_10495 ENOG4106S4J ethanolamine utilization protein EutP AM338_10500 ENOG4108VJN May be involved in the formation of a specific microcompartment in the cell in which the metabolism of potentially toxic by-products takes place AM338_10505 ENOG4105C6K Malic enzyme AM338_10515 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) AM338_10520 ENOG4105CV1 Transketolase (EC 2.2.1.1) AM338_10525 ENOG4108PVD exported protein AM338_10530 ENOG4107VIJ nudix hydrolase AM338_10535 ENOG4105BZ8 glutamate synthase AM338_10540 ENOG4105BZU Histidine kinase AM338_10545 ENOG4105BZS acriflavin resistance protein AM338_10550 ENOG4105KUZ arsenate reductase AM338_10565 ENOG4106KED esterase YpfH AM338_10570 ENOG4105E0I Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP) (By similarity) AM338_10575 ENOG4105CGZ zinc metallopeptidase AM338_10585 ENOG4107EG0 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) AM338_10595 ENOG4105RH4 Glycine cleavage system transcriptional repressor AM338_10600 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen AM338_10605 ENOG4108MFN small subunit of hydrogenase-3, iron-sulfur protein (part of formate hydrogenlyase (FHL) complex) AM338_10610 ENOG4108JPZ Monovalent cation H antiporter subunit D AM338_10615 ENOG4107TDF Formate hydrogenlyase subunit 4 AM338_10620 ENOG4105D65 subunit l AM338_10625 ENOG4107WQX hydrogenase 4 membrane subunit AM338_10630 ENOG4108JPZ Monovalent cation H antiporter subunit D AM338_10635 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) AM338_10645 ENOG4105C47 NADH ubiquinone oxidoreductase 20 kda subunit AM338_10650 ENOG4105I6X formate hydrogenlyase maturation AM338_10655 ENOG4108JUA Transcriptional regulator AM338_10660 ENOG4105TMB Formate nitrite transporter AM338_10670 ENOG4105C02 permease AM338_10675 ENOG4105ERG peptidase m48, ste24p AM338_10680 ENOG4105K89 arsenate reductase AM338_10690 ENOG4105C2W permease AM338_10710 ENOG4108V3E phosphoribosylglycinamide formyltransferase AM338_10715 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) AM338_10720 ENOG4105C9X ppx gppa phosphatase AM338_10725 ENOG4105BZU Histidine kinase AM338_10735 ENOG41062G3 Protein of unknown function (DUF2633) AM338_10745 ENOG4108ZMA Outer membrane lipoprotein AM338_10750 ENOG41066DY Membrane AM338_10760 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) AM338_10770 ENOG4105VPD cellular component movement AM338_10785 ENOG4105N21 Membrane AM338_10815 ENOG4108JQB penicillin-binding protein 1C AM338_10820 ENOG4105DN3 alpha-2-macroglobulin domain protein AM338_10825 ENOG4105KHC sulfurtransferase AM338_10830 ENOG4105YYA enhanced serine sensitivity protein SseB AM338_10840 ENOG4105WVQ Fe-S assembly protein IscX AM338_10845 ENOG4108ZIT Ferredoxin, 2FE-2S AM338_10865 ENOG4107XTC May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins AM338_10890 ENOG4107XM9 (LipO)protein AM338_10895 ENOG4108MN2 Stationary phase inducible protein CsiE AM338_10900 ENOG4105D8G Major Facilitator superfamily AM338_10905 ENOG4108W5M transcriptional regulator AM338_10910 ENOG4105FUY alpha subunit AM338_10935 ENOG4108SB3 DoxX Family AM338_10940 ENOG4108ZKT aldose 1-epimerase AM338_10945 ENOG4105CPQ Dehydrogenase AM338_10950 ENOG4105CNN ABC, transporter AM338_10955 ENOG4108F37 ATP-binding component of a transport system AM338_10960 ENOG4105FCA ABC transporter periplasmic-binding protein YphF AM338_10965 ENOG4107HQ7 repeat protein AM338_10970 ENOG4108NZE NAGC-like transcriptional regulator AM338_10980 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) AM338_10985 ENOG4108YZA Nitrogen regulatory protein pii AM338_10990 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family AM338_10995 ENOG4108SKK alpha helix protein AM338_11000 ENOG4107WP9 Histidine kinase AM338_11005 ENOG4107QIK phosphoribosylformylglycinamidine synthase AM338_11020 ENOG4108Z6B deaminase AM338_11025 ENOG4105HYY HAD superfamily (Subfamily IF) hydrolase, YfhB AM338_11030 ENOG4106G6Q Transcriptional regulator AM338_11035 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding AM338_11060 ENOG4105CSZ Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity) AM338_11085 ENOG4105C3F Signal peptidase i AM338_11095 ENOG4105WMJ Positive regulator of sigma E, RseC MucC AM338_11100 ENOG4105VQK sigma E regulatory protein, MucB RseB AM338_11105 ENOG41069PW sigma-e factor negative regulatory protein AM338_11110 ENOG4105EMN RNA polymerase sigma factor AM338_11115 ENOG4108IYU L-aspartate oxidase AM338_11120 ENOG4107S47 Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC) (By similarity) AM338_11125 ENOG4105C1J atp-dependent rna helicase AM338_11130 ENOG41090KR LysR family transcriptional Regulator AM338_11150 ENOG4105EIB trna rrna methyltransferase AM338_11160 ENOG4105K63 Thioredoxin AM338_11165 ENOG4106IUH DTW domain containing protein AM338_11170 ENOG4105CD5 CoA-binding domain protein AM338_11175 ENOG4105JIM Phosphatidylserine synthase AM338_11180 ENOG4105T42 (LipO)protein AM338_11185 ENOG4105CSH Transporter AM338_11215 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit AM338_11220 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase AM338_11225 ENOG4105C34 Pseudouridine synthase AM338_11230 ENOG4106SNF Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane AM338_11240 ENOG4108WPH sigma 54 modulation protein ribosomal protein S30EA AM338_11245 ENOG4105CQC Prephenate dehydratase AM338_11250 ENOG4105EHE chorismate mutase- prephenate dehydrogenase AM338_11255 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) AM338_11260 ENOG4105QP9 Protein of unknown function (DUF2799) AM338_11265 ENOG4108WS1 AM338_11270 ENOG4108KHX Diguanylate cyclase AM338_11275 ENOG41090EK ompa motb domain protein AM338_11300 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY AM338_11305 ENOG4106KVJ cytochrome C assembly protein AM338_11310 ENOG4108JU6 CBS domain protein AM338_11330 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) AM338_11335 ENOG4105YRI Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) AM338_11340 ENOG4105VDB UPF0125 protein AM338_11345 ENOG4108Z1B Cyclase dehydrase AM338_11360 ENOG4108MGN ATP-binding component of a transport system AM338_11390 ENOG4105E54 alpha-amylase AM338_11410 ENOG4105D5U fad dependent oxidoreductase AM338_11415 ENOG4105C26 Dehydrogenase AM338_11420 ENOG4108JPW Aminotransferase AM338_11425 ENOG4105C85 amino acid AM338_11430 ENOG4108PVQ transcriptional regulator AM338_11435 ENOG4109066 lysm domain bon superfamily protein AM338_11440 ENOG4105VPI YqaE family transport protein AM338_11445 ENOG41080HT Transcriptional regulator, arsr family AM338_11450 ENOG4108V62 Rhodanese domain protein AM338_11455 ENOG4108X73 DNA- binding protein AM338_11460 ENOG4108RNS Exports L-alanine (By similarity) AM338_11465 ENOG4108WMJ Protein of unknown function (DUF2002) AM338_11470 ENOG4108ZQZ Bacterial protein of unknown function (DUF883) AM338_11475 ENOG4105WAZ (Glutaredoxin-like protein) NrdH AM338_11480 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) AM338_11485 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) AM338_11490 ENOG4107R25 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) AM338_11500 ENOG4108IJ7 Glycine betaine AM338_11505 ENOG4108HQS Glycine betaine AM338_11510 ENOG4105GIJ Glycine betaine AM338_11520 ENOG4108UMN azlc family AM338_11525 ENOG4105ZED uncharacterized protein ygaH AM338_11530 ENOG4105NTK Transcriptional repressor Mpra AM338_11535 ENOG4105CW7 secretion protein, HlyD family AM338_11540 ENOG4105C0R drug resistance transporter emrb qaca subfamily AM338_11555 ENOG4105W39 Membrane AM338_11560 ENOG4107VXZ Hydrolase AM338_11590 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) AM338_11595 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) AM338_11610 ENOG4107TH8 cina domain protein AM338_11615 ENOG4105CVE Lytic murein transglycosylase AM338_11620 ENOG410787A Pts system, glucitol sorbitol-specific AM338_11625 ENOG4105DZY Pts system, glucitol sorbitol-specific AM338_11630 ENOG4105VI0 Pts system, glucitol sorbitol-specific AM338_11635 ENOG4107QMF Sorbitol-6-phosphate dehydrogenase AM338_11640 ENOG4105J92 DNA-binding transcriptional activator GutM AM338_11645 ENOG410804X Transcriptional regulator AM338_11650 ENOG4105C2X Arabinose 5-phosphate isomerase AM338_11660 ENOG4108ESE uses NADH to detoxify nitric oxide (NO), protecting several 4Fe-4S NO-sensitive enzymes. Has at least 2 reductase partners, only one of which (NorW, flavorubredoxin reductase) has been identified. NO probably binds to the di-iron center AM338_11670 ENOG4105C8H hydrogenase maturation protein Hypf AM338_11675 ENOG4108RC0 Electron transport protein AM338_11680 ENOG4105DDV Transcriptional regulator (LacI family AM338_11685 ENOG4105C5Y PTS System AM338_11690 ENOG4105CS2 ec 3.2.1.21 AM338_11695 ENOG4108MG9 hydrogenase 3 maturation protease AM338_11700 ENOG4105I6X formate hydrogenlyase maturation AM338_11705 ENOG4105C47 NADH ubiquinone oxidoreductase 20 kda subunit AM338_11710 ENOG4108RG7 formate hydrogenlyase complex iron-sulfur subunit AM338_11715 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) AM338_11720 ENOG4107TDF Formate hydrogenlyase subunit 4 AM338_11725 ENOG4107R30 NADH dehydrogenase AM338_11730 ENOG4108MFN small subunit of hydrogenase-3, iron-sulfur protein (part of formate hydrogenlyase (FHL) complex) AM338_11740 ENOG4108VRC Formate hydrogenlyase regulatory protein hycA AM338_11745 ENOG410816D Probably plays a role in a hydrogenase nickel cofactor insertion step (By similarity) AM338_11750 ENOG4107RSS Hydrogenase accessory protein HypB AM338_11755 ENOG41083WG hydrogenase assembly chaperone AM338_11760 ENOG4105CQS hydrogenase expression formation protein HypD AM338_11765 ENOG4105C45 hydrogenase expression formation protein (HypE) AM338_11770 ENOG4108JUA Transcriptional regulator AM338_11775 ENOG4105VXR cytoplasmic protein AM338_11785 ENOG4105MEW serine threonine protein phosphatase AM338_11790 ENOG4105MVE transcriptional regulator AM338_11795 ENOG4105ZXK Dehydrogenase AM338_11800 ENOG4105G63 Type III effector Hrp-dependent AM338_11805 ENOG4105FB2 class II Aldolase AM338_11810 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) AM338_11815 ENOG4105C6Z Gluconate AM338_11820 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AM338_11825 ENOG4108K5P (LipO)protein AM338_11860 ENOG4105N0Z inner membrane protein ygbE AM338_11880 ENOG4108MXK alkaline phosphatase isozyme conversion AM338_11885 ENOG4105PWE CRISPR-associated protein cas2 AM338_11890 ENOG4105TZK CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. May be involved in the integration of spacer DNA into the CRISPR cassette (By similarity) AM338_11895 ENOG4108Y7V CRISPR-associated protein, Cse3 family AM338_11900 ENOG4108VWQ crispr-associated protein AM338_11905 ENOG41060M0 Crispr-associated protein, cse4 family AM338_11910 ENOG41061HK CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA) AM338_11915 ENOG4105CYR Crispr-associated protein, cse1 family AM338_11920 ENOG4105DTT CRISPR-associated helicase, cas3 AM338_11945 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase AM338_11950 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase AM338_11955 ENOG4105WQV ferredoxin-like protein AM338_11960 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator AM338_11965 ENOG4105YBM electron transfer flavoprotein subunit ygcQ AM338_11970 ENOG4106IKH Electron transfer flavoprotein AM338_11975 ENOG4105C54 Major Facilitator superfamily AM338_11980 ENOG4107R3A FAD linked oxidase domain protein AM338_11985 ENOG4105CHR reductase AM338_11990 ENOG4108ITV Inner membrane protein yqcE AM338_11995 ENOG4108CWB sugar kinase ygcE AM338_12000 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) AM338_12010 ENOG4105HA9 of methanol dehydrogenase type AM338_12025 ENOG4105DXN mazG family AM338_12030 ENOG4105MZG transcriptional modulator of maze toxin, mazf AM338_12035 ENOG4106A2Z transcriptional regulator antitoxin, MazE AM338_12040 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) AM338_12045 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) AM338_12050 ENOG4105BZU Histidine kinase AM338_12055 ENOG4105EQX glucarate dehydratase AM338_12060 ENOG4105EQX glucarate dehydratase AM338_12065 ENOG4105DJB Major Facilitator Superfamily AM338_12070 ENOG4105QDK Flavodoxin AM338_12075 ENOG4105DR9 pseudouridine synthase AM338_12080 ENOG4105WP7 tRNA pseudouridine synthase C AM338_12095 ENOG4105EWT decarboxylase family AM338_12100 ENOG4105C44 Serine transporter AM338_12105 ENOG4105EJQ L-serine dehydratase AM338_12115 ENOG4105C0A alcohol dehydrogenase AM338_12120 ENOG4107W7X Aldolase AM338_12125 ENOG4105EDR glucose galactose transporter AM338_12135 ENOG4105CMG Carbohydrate kinase AM338_12145 ENOG4107EDW L-fucose operon activator AM338_12155 ENOG4105M08 Membrane AM338_12160 ENOG4105ETT transcriptional Regulator, LysR family AM338_12165 ENOG4105M5B (LipO)protein AM338_12170 ENOG4105C9B Cysteine desulfurase AM338_12175 ENOG4105P9C Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity) AM338_12180 ENOG4105CUZ uba thif-type nad fad binding protein AM338_12185 ENOG4105CA3 membrane-bound lytic murein transglycosylase AM338_12210 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase AM338_12215 ENOG4107QZM n-acetylglutamate synthase AM338_12220 ENOG4107QYX exodeoxyribonuclease v alpha AM338_12225 ENOG4107QKA exodeoxyribonuclease V beta AM338_12230 ENOG4107QXK peptidase AM338_12235 ENOG4105DSY exodeoxyribonuclease V, gamma AM338_12240 ENOG4105RVB Prepilin peptidase dependent protein c AM338_12245 ENOG4105SEN Protein of unknown function (DUF2509) AM338_12250 ENOG4105JCS prepilin peptidase dependent protein AM338_12255 ENOG4105IPU prepilin peptidase dependent protein A AM338_12270 ENOG4108HRM phosphoenolpyruvate--protein phosphotransferase AM338_12285 ENOG4105EE5 Membrane protein terC AM338_12290 ENOG4105SUV lipoprotein YgdR AM338_12295 ENOG4105CPC Aldo Keto reductase AM338_12310 ENOG41060NJ transcriptional regulator AM338_12315 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) AM338_12320 ENOG4105RQF LysR family Transcriptional regulator AM338_12330 ENOG4107QNK )-transporter AM338_12335 ENOG4105CHR reductase AM338_12345 ENOG4105CHU acetyl-coa acetyltransferase AM338_12350 ENOG4108MHD transport protein AM338_12355 ENOG4105ISV protein with bipartite regulator domain AM338_12360 ENOG4108TC1 Transcriptional regulator AM338_12365 ENOG4105FV3 AM338_12400 ENOG4108YAB Invasion protein AM338_12445 ENOG4108RBT type iii secretion AM338_12450 ENOG4106BTR AM338_12455 ENOG4105Y7Q type iii secretion AM338_12460 ENOG4108RC9 Type III secretion system protein AM338_12490 ENOG4108M6W surface presentation of antigens protein SpaS AM338_12495 ENOG4108M6W surface presentation of antigens protein SpaS AM338_12500 ENOG4108TN6 type iii secretion AM338_12510 ENOG41075IY surface presentation of antigens protein SpaP AM338_12525 ENOG4108SER Transposase AM338_12530 ENOG4108T88 AM338_12560 ENOG4108IYT Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) AM338_12570 ENOG4108K5P (LipO)protein AM338_12580 ENOG4105C7W Xanthine dehydrogenase AM338_12585 ENOG4108HR6 Dehydrogenase AM338_12590 ENOG4108UTP (2Fe-2S)-binding domain protein AM338_12595 ENOG4108JUB Transcriptional regulator AM338_12600 ENOG4105IW6 Carbamoyltransferase AM338_12605 ENOG4107RCH Diaminopropionate ammonia-lyase AM338_12610 ENOG4107S4Y M20 DapE family protein YgeY AM338_12620 ENOG4105C5B carbamate kinase AM338_12625 ENOG4107P0T Selenium-dependent molybdenum hydroxylase system protein, YqeB family AM338_12630 ENOG4105MJ6 selenium-dependent hydroxylase accessory protein YqeC AM338_12635 ENOG4105MFX 4-diphosphocytidyl-2c-methyl-d-erythritol synthase AM338_12640 ENOG4105BZ8 glutamate synthase AM338_12645 ENOG4107UUR Chlorohydrolase aminohydrolase AM338_12650 ENOG410873Y FAD binding domain in molybdopterin dehydrogenase AM338_12655 ENOG4105C7W Xanthine dehydrogenase AM338_12660 ENOG4105C2W permease AM338_12665 ENOG4107QUY Guanine deaminase AM338_12670 ENOG4105C7N Xanthine uracil vitamin C permease AM338_12675 ENOG4108R8B oxidoreductase Fe-S subunit AM338_12680 ENOG4105BZ8 glutamate synthase AM338_12690 ENOG4105C2W permease AM338_12705 ENOG4105CRK lysyL-tRNA synthetase AM338_12715 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) AM338_12720 ENOG4105T95 Thiol disulfide interChange protein AM338_12725 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) AM338_12730 ENOG41071R3 Low-potential electron donor to a number of redox enzymes (By similarity) AM338_12735 ENOG4108YDB Toxic component of a toxin-antitoxin (TA) module. Overexpression leads to growth arrest after 5 hours, with initial elongation of cells, followed by swelling. The toxic effects are abrogated by coexpression with antitoxin CptB. Interacts with cytoskeletal proteins FtsZ and MreB AM338_12740 ENOG4105Y75 tpr repeat protein AM338_12750 ENOG4108UT2 hemolysin iii AM338_12755 ENOG4105N5Z UPF0267 protein AM338_12760 ENOG4105CS2 ec 3.2.1.21 AM338_12765 ENOG4105CYX Short-chain dehydrogenase reductase Sdr AM338_12785 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family AM338_12790 ENOG4105D0A hydroxylase AM338_12795 ENOG4107RAQ aminopeptidase AM338_12820 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase AM338_12835 ENOG4108JQ1 Dehydrogenase AM338_12860 ENOG4105D5P Methylmalonyl-coA mutase AM338_12865 ENOG4105DJT lAO AO transport system ATPase AM338_12870 ENOG4108M7F enoyl-CoA hydratase isomerase AM338_12875 ENOG4105CYC Transferase AM338_12880 ENOG4105DEQ transcriptional regulator AM338_12890 ENOG4108ZUB Lysine exporter protein (Lyse ygga) AM338_12895 ENOG4105D64 Mechanosensitive ion channel AM338_12900 ENOG4105D2N Aldolase AM338_12920 ENOG4107Z1W Fructose transport system kinase AM338_12925 ENOG4108R4K DNA-binding, transcriptional regulator AM338_12930 ENOG4108Q8A Fructose-1,6-bisphosphatase AM338_12935 ENOG4105DXH Alcohol dehydrogenase zinc-binding domain protein AM338_12940 ENOG4105CTS PTS system mannitol-specific AM338_12945 ENOG4108X7Y Mannitol-specific cryptic phosphotransferase enzyme iia AM338_12950 ENOG4105CV1 Transketolase (EC 2.2.1.1) AM338_12955 ENOG4108K0D peptidase, M48 AM338_12965 ENOG4105DP5 Catalyzes the biosynthesis of agmatine from arginine (By similarity) AM338_12990 ENOG4107QNK )-transporter AM338_13000 ENOG4105RWS endonuclease I AM338_13005 ENOG4105QF0 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) AM338_13010 ENOG4105D7Z glutathione synthase AM338_13025 ENOG4105CZX twitching motility protein AM338_13030 ENOG4105DFA alanine racemase domain protein AM338_13035 ENOG4108VIA integral membrane protein AM338_13045 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) AM338_13050 ENOG4105CSA Coproporphyrinogen iii oxidase AM338_13055 ENOG4106MH3 alpha helix chain AM338_13060 ENOG4105HDK L-asparaginase AM338_13065 ENOG4105K33 Periplasmic Protein AM338_13070 ENOG41090ED Protein with unknown function (DUF469) AM338_13085 ENOG4105CEN a g-specific adenine glycosylase AM338_13100 ENOG4105EAA nucleoside AM338_13105 ENOG4105CXN decarboxylase AM338_13115 ENOG4108UQV Membrane AM338_13150 ENOG4108YXQ IS66 Orf2 family protein AM338_13155 ENOG4105E5H Transposase AM338_13170 ENOG41067TZ transcriptional regulator, MarR family AM338_13185 ENOG4105D5Q Arginine ornithine antiporter AM338_13190 ENOG4105CXN decarboxylase AM338_13195 ENOG4105D5Q Arginine ornithine antiporter AM338_13210 ENOG4105D3Z quinone oxidoreductase, yhdh yhfp family AM338_13275 ENOG4105D5K Hemolysin activator protein AM338_13300 ENOG4108VPX Involved in 1,2-propanediol (1,2-PD) degradation by catalyzing the conversion of propanoyl-CoA to propanoyl-phosphate (By similarity) AM338_13305 ENOG4107RWI ethanolamine utilization protein eutJ AM338_13315 ENOG4105WVM ethanolamine utilization protein EutN carboxysome structural protein Ccml AM338_13330 ENOG4105KNY Microcompartments protein AM338_13335 ENOG4105EHR propanediol utilization protein pduB AM338_13340 ENOG4108EKI Dehydrogenase AM338_13350 ENOG4107R7Y intracellular protease Pfpi family AM338_13355 ENOG4105C6N Formate acetyltransferase AM338_13360 ENOG4105F1A Pyruvate formate-lyase AM338_13380 ENOG4105EKQ RNA-directed DNA polymerase AM338_13385 ENOG4105C2F Histidine kinase AM338_13390 ENOG4106R3P AraC family transcriptional regulator AM338_13395 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP AM338_13400 ENOG4105KNY Microcompartments protein AM338_13405 ENOG4108W3Q Transcriptional regulator AM338_13415 ENOG4108IG5 Transcriptional regulator AM338_13460 ENOG4105TS0 gtp-binding protein AM338_13465 ENOG4108KZE transcriptional regulator AM338_13480 ENOG4106H6R UPF0380 protein AM338_13485 ENOG4106549 Antirestriction protein AM338_13490 ENOG4108YGG dna repair protein AM338_13495 ENOG4106WJE Protein of unknown function (DUF987) AM338_13500 ENOG4105MAW Antitoxin component of a toxin-antitoxin (TA) module. Labile antitoxin that counteracts the effect of the CbtA (YeeV) toxin. It does not bind to the cognate toxin but instead binds to MreB and FtsZ (the toxin targets), enhancing their polymerization by forming higher-order bundles AM338_13525 ENOG4105U1E general secretion pathway protein M AM338_13545 ENOG4105X5Z General secretion pathway protein I AM338_13555 ENOG4108VAU general secretion pathway protein G AM338_13560 ENOG4105D7Q type ii secretion system AM338_13575 ENOG4108XKW General secretion pathway protein C AM338_13580 ENOG410765S (LipO)protein AM338_13585 ENOG4105EHH Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue (By similarity) AM338_13590 ENOG4105F88 accessory colonization factor AcfD AM338_13600 ENOG4105DAA L-lactate AM338_13605 ENOG4107QP3 malate synthase g AM338_13610 ENOG4108ZJF Glcg protein AM338_13615 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) AM338_13620 ENOG4105EU8 FAD linked oxidase domain protein AM338_13625 ENOG4105CQB FAD linked oxidase domain protein AM338_13630 ENOG4108KWP DNA-binding transcriptional regulator GlcC AM338_13640 ENOG4107RCI amp-dependent synthetase and ligase AM338_13650 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) AM338_13655 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) AM338_13665 ENOG4108M8S permease YjgP YjgQ family protein AM338_13670 ENOG4108UUE Transcriptional regulator AM338_13680 ENOG4108S55 polysaccharide biosynthesis protein AM338_13685 ENOG4106FPV ATP-binding protein YghR AM338_13690 ENOG4108NDC ATP-binding protein yghS AM338_13695 ENOG4108GH0 ATP-binding protein yghT AM338_13700 ENOG4105CJ3 phosphate transporter AM338_13705 ENOG4106032 Glutathionylspermidine synthase AM338_13710 ENOG4105CYM Glutathione S-transferase AM338_13715 ENOG41082MF Hydrogenase assembly chaperone hypC hupF AM338_13720 ENOG4105WMM Probably plays a role in a hydrogenase nickel cofactor insertion step (By similarity) AM338_13725 ENOG4108WGS hydrogenase 2-specific chaperone AM338_13730 ENOG4108USZ hydrogenase AM338_13735 ENOG4105DPX Hydrogenase, large subunit AM338_13740 ENOG4105CJ5 hydrogenase 2 b cytochrome subunit AM338_13745 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein AM338_13750 ENOG4105E3S small subunit AM338_13760 ENOG410900S Protein of unknown function (DUF2623) AM338_13775 ENOG4105CPC Aldo Keto reductase AM338_13785 ENOG4105CYX Short-chain dehydrogenase reductase Sdr AM338_13790 ENOG4108ZZF transport protein (ExbD) AM338_13795 ENOG4105CWK Biopolymer transport protein, ExbB AM338_13805 ENOG4105C28 cystathionine AM338_13810 ENOG4108K81 inner membrane protein YghB AM338_13815 ENOG4105CF7 AraC family transcriptional regulator AM338_13820 ENOG4108I6A alcohol dehydrogenase AM338_13825 ENOG4105CV8 reductase AM338_13830 ENOG4105ZKC Conserved Protein AM338_13840 ENOG4105CCT upf0313 protein AM338_13845 ENOG4107TZ2 Cell division protein that is required for growth during stress conditions. May be involved in protecting or stabilizing the divisomal assembly under conditions of stress (By similarity) AM338_13850 ENOG4107S7E 1-acyl-sn-glycerol-3-phosphate acyltransferase AM338_13855 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) AM338_13860 ENOG4108J59 Extracellular solute-binding protein, family 5 AM338_13865 ENOG4105WJ3 XRE family Transcriptional regulator AM338_13870 ENOG4105RT5 Toxic component of a toxin-antitoxin (TA) module. An mRNA interferase which has been reported to be translation- independent (PubMed 19690171, PubMed 19943910) and translation- dependent (PubMed 20041169). Cleavage has been reported to occur on either side of G in the sequence GCU (PubMed 19690171) but also after C in GC(A U) sequences (PubMed 19943910). There are only 14 genes in E.coli W3110 (and probably also MG1655) that do not have a GCU sequence and thus are resistant to the mRNA interferase activity. Overexpression causes cessation of cell growth and inhibits cell proliferation via inhibition of translation as well as increasing persister cell formation AM338_13875 ENOG4105F4I Transcriptional regulator AM338_13880 ENOG4105H4F exported protein AM338_13885 ENOG4105XJC Two component transcriptional regulator (Winged helix family AM338_13890 ENOG4105DHQ Histidine kinase AM338_13895 ENOG4107DEU Inner membrane protein YgiZ AM338_13905 ENOG4105NF4 modulator of drug activity AM338_13910 ENOG4105VRH Antibiotic biosynthesis monooxygenase AM338_13915 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) AM338_13920 ENOG4105IPS esterase AM338_13925 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) AM338_13930 ENOG4108SX3 cytoplasmic protein AM338_13935 ENOG41087AY ADP-Ribose pyrophosphatase AM338_13940 ENOG4105DFG type I secretion outer membrane protein AM338_13955 ENOG4106032 Glutathionylspermidine synthase AM338_13960 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b AM338_13980 ENOG4105W0Z cytoplasmic protein AM338_13985 ENOG4105H8W Fimbrial protein AM338_13995 ENOG4108TTM chaperone AM338_14000 ENOG4108MY7 Fimbrial AM338_14010 ENOG4105PV3 Inner membrane protein yqiJ AM338_14015 ENOG4107S78 Band 7 protein AM338_14035 ENOG4105I7R Adenylate cyclase AM338_14045 ENOG4106MWK domain protein AM338_14055 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) AM338_14060 ENOG4107ZVW dihydroneopterin aldolase AM338_14070 ENOG4105EJC lysr family transcriptional regulator AM338_14080 ENOG4106DSS Tartrate dehydratase subunit alpha AM338_14085 ENOG4107GFK fumarate AM338_14090 ENOG4107QPK )-transporter AM338_14105 ENOG4105VCC 30S ribosomal protein S21 AM338_14110 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) AM338_14120 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AM338_14135 ENOG4105Q26 Siderophore-interacting protein AM338_14145 ENOG4105NTW Transcriptional regulator AM338_14150 ENOG4107RHT methyl-accepting chemotaxis sensory transducer with Pas Pac sensor AM338_14165 ENOG4108Y51 tRNA-binding protein AM338_14175 ENOG4105CQ4 Transcriptional regulator AM338_14180 ENOG4105CNT hydrolase family 2 AM338_14185 ENOG4105FK9 beta-D-galactosidase beta subunit AM338_14190 ENOG4105E5D amino acid AM338_14195 ENOG4107W6W Conserved Protein AM338_14200 ENOG4107WCA isomerase AM338_14205 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase AM338_14210 ENOG4108Z3N Transcriptional regulator AM338_14215 ENOG4105R48 this blockage is overcome by subsequent expression of antitoxin HigA. Overexpression causes cleavage of a number of mRNAs in a translation-dependent fashion, suggesting this is an mRNA interferase AM338_14225 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) AM338_14230 ENOG4108VKG metal-dependent hydrolase AM338_14235 ENOG4108UB4 uncharacterized protein ygjQ AM338_14240 ENOG4105EE0 oxidoreductase AM338_14245 ENOG4105DU1 integral membrane protein, terc AM338_14250 ENOG4107QV7 Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system) (By similarity) AM338_14255 ENOG4105P66 Membrane AM338_14260 ENOG4105CTX dehydratase AM338_14270 ENOG4105DPW Major facilitator superfamily MFS_1 AM338_14275 ENOG4107YCY Transcriptional regulator AM338_14280 ENOG4106W5V Membrane AM338_14285 ENOG4105IYR Modulates the activity of the EnvZ OmpR two-component regulatory system, probably by directly modulating EnvZ enzymatic activity and increasing stability of phosphorylated OmpR (By similarity) AM338_14290 ENOG4105WAY exported protein AM338_14295 ENOG4105NE1 Conserved Protein AM338_14300 ENOG41090KG Inner membrane protein YqjE AM338_14305 ENOG4105YJD AM338_14310 ENOG4108VBZ doxx family AM338_14315 ENOG4105CHF Glutathione S-transferase AM338_14320 ENOG4105KAF membrAne AM338_14340 ENOG4105KAF membrAne AM338_14350 ENOG4105CWB LysR family transcriptional Regulator AM338_14355 ENOG4108CNN domain protein AM338_14360 ENOG4106D80 Uncharacterized protein YhaL AM338_14370 ENOG4105C44 Serine transporter AM338_14375 ENOG4105EJQ L-serine dehydratase AM338_14380 ENOG4105KME endoribonuclease L-psp AM338_14385 ENOG4105C6N Formate acetyltransferase AM338_14390 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) AM338_14400 ENOG4105C7B Threonine dehydratase AM338_14405 ENOG410811B TRANSCRIPTIONal AM338_14430 ENOG4105BZW Glycerate kinase AM338_14435 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase AM338_14445 ENOG4105DJB Major Facilitator Superfamily AM338_14450 ENOG4105CTX dehydratase AM338_14455 ENOG4105ZEG Suppressor protein AM338_14460 ENOG4108R8Z these effects are overcome by concomitant expression of antitoxin SohA (PrlF). Massive overexpression is toxic. Unlike most other characterized TA systems degrades rRNA, and co-folding of the proteins is necessary in vitro for inhibition of the RNase activity. It is not known if it has any sequence-specificity. Acts as a transcription factor. The YhaV PrlF complex binds the prlF-yhaV operon, probably negatively regulating its expression AM338_14465 ENOG4105E98 transcriptional regulator DeoR family AM338_14480 ENOG4108RG5 PTS system N-acetylgalactosamine-specific transporter subunit IIB AM338_14490 ENOG4105F3R pts system mannose fructose sorbose family iid AM338_14495 ENOG4108YTN IIa component AM338_14500 ENOG4105CE4 GlcNAc 6-P deacetylase AM338_14505 ENOG4105E70 isomerase AM338_14515 ENOG4108UZY PTS System AM338_14530 ENOG4105ETZ PTS System AM338_14535 ENOG4105F3R pts system mannose fructose sorbose family iid AM338_14540 ENOG4106HBN Galactosamine-6-phosphate isomerase AM338_14545 ENOG4105Q10 Fimbrial-like protein AM338_14550 ENOG4108VCD Chaperone AM338_14555 ENOG4105CW0 outer membrane usher protein AM338_14560 ENOG4105I74 Fimbrial protein AM338_14565 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) AM338_14570 ENOG4105E1C Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1A (PBP1a) (By similarity) AM338_14580 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) AM338_14585 ENOG4105W4M Transport-associated protein AM338_14590 ENOG4107S21 permease AM338_14595 ENOG4105K4T epimerase AM338_14600 ENOG4107R7Y intracellular protease Pfpi family AM338_14615 ENOG4108YYD acetyltransferase AM338_14620 ENOG4105XPQ lipid carrier protein AM338_14625 ENOG4105CFP Peptidase U32 AM338_14630 ENOG4106RZ4 Peptidase U32 AM338_14635 ENOG4105DEN Luciferase family AM338_14640 ENOG4105CIC tryptophan-specific transport protein AM338_14645 ENOG4105C1J atp-dependent rna helicase AM338_14655 ENOG4105RT1 May be involved in cell division (By similarity) AM338_14670 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) AM338_14685 ENOG4105CHV Transcription elongation factor NusA AM338_14705 ENOG4105DIJ Phosphoethanolamine transferase AM338_14730 ENOG4105EEI dihydropteroate synthase AM338_14735 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) AM338_14740 ENOG4105F7M Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit (By similarity) AM338_14745 ENOG4105HBR Rna-binding protein AM338_14750 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) AM338_14755 ENOG4106HRJ d-alanyl-d-alanine carboxypeptidase AM338_14760 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control AM338_14765 ENOG4105QYV Membrane AM338_14780 ENOG4105EAH synthase AM338_14785 ENOG4105HVQ Regulatory factor of maltose metabolism AM338_14795 ENOG4105VFK BolA family AM338_14800 ENOG4105UE2 Part of the ABC transporter complex MlaFEDB that actively prevents phospholipid accumulation at the cell surface. Probably maintains lipid asymmetry in the outer membrane by retrograde trafficking of phospholipids from the outer membrane to the inner membrane AM338_14805 ENOG4105E3I toluene tolerance AM338_14810 ENOG4107PE3 Mammalian cell entry related domain protein AM338_14815 ENOG4105CY3 ABC transporter, permease AM338_14820 ENOG4105DHJ ABC, transporter AM338_14825 ENOG4105FEU K -dependent Na -Ca exchanger AM338_14830 ENOG4105C2X Arabinose 5-phosphate isomerase AM338_14835 ENOG4108Z4R 3-deoxy-d-manno-octulosonate 8-phosphate phosphatase AM338_14840 ENOG4108P1K Required for the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane (By similarity) AM338_14845 ENOG4105WI0 lipopolysaccharide transport periplasmic protein lptA AM338_14850 ENOG4108IUZ ABC transporter AM338_14855 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AM338_14860 ENOG41080QH sigma 54 modulation protein ribosomal protein S30EA AM338_14865 ENOG4107RM2 PTS IIA-like nitrogen-regulatory protein PtsN AM338_14875 ENOG41080Z8 PHOSPHOCARRIER protein AM338_14880 ENOG4108NIH transferase activity, transferring phosphorus-containing groups AM338_14890 ENOG4108556 Isoprenoid biosynthesis protein with amidotransferase-like domain AM338_14895 ENOG4105BZU Histidine kinase AM338_14900 ENOG4105N5T Radical SAM Protein AM338_14915 ENOG4105CBC glutamate synthase AM338_14920 ENOG4105BZ8 glutamate synthase AM338_14930 ENOG4106AJS Involved in induction of the so-called NTR enzymes in response to nitrogen deprivation, as well as in glutamate biosynthesis. May mediate the glutamate-dependent repression of the GLT operon AM338_14935 ENOG4108S1B Periplasmic chaperone protein AM338_14940 ENOG4105E6S usher protein( AM338_14950 ENOG4105UMR response to DNA damage stimulus AM338_14965 ENOG4105EKQ RNA-directed DNA polymerase AM338_14980 ENOG4105DFS Conserved Protein AM338_14985 ENOG4108R66 Conserved Protein AM338_15020 ENOG4105CEE C4-dicarboxylate transporter AM338_15025 ENOG4105KB2 stringent starvation protein b AM338_15030 ENOG4107MKT Stringent starvation protein a AM338_15040 ENOG4108UJD 30S ribosomal protein S9 AM338_15050 ENOG4105D6Z AFG1 family ATPase AM338_15055 ENOG4108W2Q Cytochrome d ubiquinol oxidase subunit III AM338_15060 ENOG4105C0H protease AM338_15065 ENOG4105C0H protease AM338_15080 ENOG4105RID UPF0379 protein yhcN AM338_15085 ENOG4105UNR (Barnase) inhibitor AM338_15105 ENOG4105CR8 Transcriptional regulator AM338_15110 ENOG4105D1U peptidase U62 modulator of DNA gyrase AM338_15115 ENOG4105QD6 exported protein AM338_15120 ENOG4105C03 ribonuclease AM338_15125 ENOG4108Z03 MAF-like protein AM338_15130 ENOG4105VQ7 Rod shape-determining protein MreD AM338_15135 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) AM338_15140 ENOG4105DFF Rod shape-determining protein mreb AM338_15155 ENOG41062P1 Diguanylate cyclase phosphodiesterase AM338_15160 ENOG4105D3Z quinone oxidoreductase, yhdh yhfp family AM338_15170 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein AM338_15175 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase AM338_15180 ENOG4105RG0 Membrane AM338_15185 ENOG4108IA2 Sodium pantothenate symporter AM338_15195 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) AM338_15200 ENOG4105VY0 Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters (By similarity) AM338_15205 ENOG4105CEC DNA methylase N-4 N-6 AM338_15225 ENOG4105BZS acriflavin resistance protein AM338_15230 ENOG4105XCM membrane LIPOPROTEIN AM338_15250 ENOG4105EZ7 amino acid ABC transporter AM338_15255 ENOG4105DRP amino acid AbC transporter AM338_15260 ENOG4105CDA abc transporter atp-binding protein AM338_15300 ENOG4108Z0R Transferase AM338_15305 ENOG4105SG3 Protein of unknown function (DUF1488) AM338_15315 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) AM338_15320 ENOG4108WI1 Dna topoisomerase AM338_15330 ENOG4105C79 DNA protecting protein DprA AM338_15350 ENOG4105C1A potassium transporter peripheral membrane AM338_15360 ENOG4105VCN Rescues the ribosomes stalled at the 3' end of non-stop mRNAs. May induce hydrolysis of the ribosome-bound peptidyl-tRNA. This activity is crucial when the stalled ribosome can not be rescued by the SsrA(tmRNA)-SmpB quality control system AM338_15365 ENOG4105W1Y Transcriptional regulator AM338_15370 ENOG4105VTS DnaJ-like, subfamily C AM338_15380 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) AM338_15385 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) AM338_15395 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits AM338_15400 ENOG41067V7 50S ribosomal protein L36 AM338_15405 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) AM338_15420 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) AM338_15425 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) AM338_15435 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) AM338_15450 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) AM338_15460 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal AM338_15470 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) AM338_15475 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) AM338_15480 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) AM338_15485 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) AM338_15495 ENOG41080KG One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) AM338_15500 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) AM338_15520 ENOG4107ACA Calcium-binding protein required for initiation of chromosome replication AM338_15525 ENOG410899B May play a regulatory role under conditions of derepressed gsp gene expression AM338_15530 ENOG4107KSE General secretion pathway protein C AM338_15535 ENOG4105GVR general secretion pathway protein D AM338_15540 ENOG4107QHF type ii secretion system protein e AM338_15545 ENOG4105D7Q type ii secretion system AM338_15550 ENOG4108VAU general secretion pathway protein G AM338_15555 ENOG41069X0 general secretion pathway protein h AM338_15575 ENOG41063JA Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins (By similarity) AM338_15585 ENOG4105EHH Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue (By similarity) AM338_15590 ENOG4108UQY Iron-storage protein AM338_15595 ENOG4105W53 bacterioferritin-associated ferredoxin AM338_15600 ENOG4108NNZ chitinase AM338_15645 ENOG4105WWK YheO domain protein AM338_15650 ENOG4108V1T peptidylprolyl cis-trans isomerase AM338_15660 ENOG4108YZY peptidylprolyl cis-trans isomerase AM338_15665 ENOG4105VKU nucleicacid-binding protein AM338_15685 ENOG4105C5H ABC transporter AM338_15690 ENOG4105DNZ Alpha Beta Hydrolase AM338_15700 ENOG4105CJE phosphoribulokinase (EC 2.7.1.19) AM338_15705 ENOG4108UKZ OsmC family AM338_15715 ENOG4107RYR Transcriptional regulator, Crp Fnr family AM338_15720 ENOG410613R integral membrane protein, YccS YhfK family AM338_15725 ENOG4105C8Y Acetylornithine aminotransferase AM338_15730 ENOG4105DDQ anthranilate synthase AM338_15735 ENOG4105MZU cell filamentation protein AM338_15740 ENOG4106195 uncharacterized protein yhfG AM338_15745 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) AM338_15755 ENOG4107QZF nitrite reductase NADPH large subunit AM338_15760 ENOG4105WZK nitrite reductase NADPH small subunit AM338_15765 ENOG4107V9H nitrite transporter AM338_15775 ENOG4105VYH AM338_15780 ENOG4107QHQ amino acid AM338_15785 ENOG4107R1S catalyzes the conversion of fructoselysine 6-phosphate to glucose 6-phosphate and lysine AM338_15795 ENOG4107Y0V Not clear, may be involved in an isomerization step AM338_15800 ENOG4108KPW sugar kinase AM338_15805 ENOG4105FDP GntR family transcriptional regulator AM338_15810 ENOG4106PKC pyridoxal phosphate binding AM338_15815 ENOG4106M0N transport system permease protein AM338_15820 ENOG4105MUZ Protein of unknown function DUF2620 AM338_15825 ENOG41080QX K07048 phosphotriesterase-related protein AM338_15830 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) AM338_15835 ENOG4108626 Racemase AM338_15840 ENOG4105RMW regulation of transcription, DNA-dependent AM338_15845 ENOG4108M21 AM338_15855 ENOG4105C31 Tryptophanyl-tRNA synthetase AM338_15860 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) AM338_15865 ENOG4105DJV ribulose-phosphate 3-epimerase AM338_15870 ENOG4105DFE Dna adenine methylase AM338_15875 ENOG4105EGB membrane protein DamX AM338_15890 ENOG4105E4G Type IV pilus AM338_15895 ENOG4105ITY Required for the use of extracellular DNA as a nutrient AM338_15900 ENOG4105XPX DNA utilization protein HofO AM338_15905 ENOG41065NF Fimbrial assembly family protein AM338_15910 ENOG4108U1Q Pilus assembly protein AM338_15915 ENOG4108JQC penicillin-binding protein 1A AM338_15920 ENOG4107RK2 ADP-ribose diphosphatase NudE AM338_15925 ENOG4105DQY intracellular growth attenuator AM338_15930 ENOG4107Y3D HAD-superfamily hydrolase subfamily IA variant 3 AM338_15935 ENOG4105VEJ Heat shock protein AM338_15945 ENOG4108MAJ Membrane AM338_15960 ENOG4105E0F Histidine kinase AM338_15965 ENOG4105DPZ Two component transcriptional regulator (Winged helix family AM338_15975 ENOG4108RRZ Transcription elongation factor GreB AM338_15980 ENOG4105BZM domain protein AM338_15990 ENOG4105XFK Ferrous iron transport protein A AM338_15995 ENOG4105CE1 Ferrous iron transport protein b AM338_16010 ENOG4105DNE Transposase AM338_16020 ENOG4105MJ2 Competence protein AM338_16030 ENOG4105C6Z Gluconate AM338_16035 ENOG4107RTM 4-alpha-glucanotransferase (EC 2.4.1.25) AM338_16040 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) AM338_16055 ENOG4105E0Y RtcB Protein AM338_16060 ENOG4105CYB regulatoR AM338_16065 ENOG4105E98 transcriptional regulator DeoR family AM338_16080 ENOG4105C6V Glycerol-3-phosphate dehydrogenase AM338_16095 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) AM338_16120 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) AM338_16125 ENOG41076UM multiple antibiotic resistance (MarC)-related protein AM338_16130 ENOG4105C6Z Gluconate AM338_16135 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family AM338_16140 ENOG4105DIQ Transcriptional regulator AM338_16145 ENOG4105C2I pirin domain protein AM338_16150 ENOG4105D9R oxidoreductase AM338_16160 ENOG4105WCN acetyltransferase AM338_16165 ENOG4105GMB type VI secretion system effector, hcp1 family AM338_16180 ENOG4106FA4 AM338_16185 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) AM338_16195 ENOG4107T6V glycerophosphoryl diester phosphodiesterase AM338_16200 ENOG4108IJ9 (ABC) transporter AM338_16205 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component AM338_16210 ENOG4105E4X binding-protein-dependent transport systems inner membrane Component AM338_16215 ENOG4105BZ7 extracellular solute-binding protein family 1 AM338_16220 ENOG4108IV0 ABC, transporter AM338_16225 ENOG4105C0Z ABC transporter AM338_16230 ENOG4105CF8 branched-chain amino acid ABC transporter, permease AM338_16235 ENOG4105C32 Amino acid ABC transporter (Permease) AM338_16240 ENOG4105CP9 extracellular ligand-binding receptor AM338_16250 ENOG4105U59 -acetyltransferase AM338_16255 ENOG4105CP9 extracellular ligand-binding receptor AM338_16260 ENOG4105DEK Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) AM338_16265 ENOG4105CRP Part of the ABC transporter FtsEX involved in AM338_16270 ENOG4105CAK Cell division ATP-binding protein ftsE AM338_16275 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) AM338_16280 ENOG4106H78 methyltransferase AM338_16285 ENOG4105MG3 Membrane AM338_16295 ENOG4107FS9 Membrane AM338_16300 ENOG4105C59 p-type ATPase AM338_16310 ENOG4105EX9 Membrane AM338_16315 ENOG4108W1V Lipoprotein AM338_16320 ENOG4105F9N Major Facilitator Superfamily AM338_16325 ENOG4105DSF transport protein AM338_16330 ENOG4107YAK holo-(acyl carrier protein) synthase 2 AM338_16335 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein AM338_16340 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component AM338_16345 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component AM338_16350 ENOG4106665 Part of the ABC transporter complex NikABCDE involved in nickel import. Responsible for energy coupling to the transport system (By similarity) AM338_16355 ENOG4105EFJ Part of the ABC transporter complex NikABCDE involved in nickel import. Responsible for energy coupling to the transport system (By similarity) AM338_16365 ENOG4105CNA YD repeat protein AM338_16375 ENOG4105NUP lyase containing HEAT-repeat AM338_16380 ENOG410600T transposase AM338_16385 ENOG4105CMI transporter AM338_16390 ENOG4105CJ1 ABC, transporter AM338_16395 ENOG4105D0S secretion protein (HlyD AM338_16415 ENOG4107UNS conserved inner membrane protein AM338_16420 ENOG4105CBX hi0933 family AM338_16425 ENOG4105CJ3 phosphate transporter AM338_16435 ENOG4108M6U Universal stress protein A AM338_16445 ENOG4105DUX Transporter AM338_16450 ENOG4105FFN Specifically methylates the guanosine in position 1516 of 16S rRNA (By similarity) AM338_16455 ENOG4105DGW oligopeptidase A AM338_16460 ENOG4105D6S protein involved in catabolism of external DNA AM338_16465 ENOG4105DC8 reductase AM338_16480 ENOG4105KBH arsR family transcriptional regulator AM338_16485 ENOG4107R5R arsenical pump membrane protein AM338_16490 ENOG4105K89 arsenate reductase AM338_16500 ENOG4105Y4Z Outer Membrane Lipoprotein AM338_16515 ENOG4105KT7 mgtC SapB transporter AM338_16520 ENOG4105XXV Acid-resistance protein AM338_16525 ENOG41060V2 Acid-resistance protein AM338_16530 ENOG4108YK4 Acid-resistance membrane protein AM338_16535 ENOG4106WJ0 Regulates the expression of several genes involved in acid resistance. Required for the expression of gadA and gadBC, among others, regardless of media or growth conditions. Binds directly to the 20 bp GAD box found in the control regions of both loci AM338_16545 ENOG4105C1P efflux transporter, rnd family, mfp subunit AM338_16550 ENOG4105BZS acriflavin resistance protein AM338_16560 ENOG4105D3F AraC Family Transcriptional Regulator AM338_16565 ENOG4108NKV transcriptional regulator AM338_16570 ENOG4105CVK Glutamate decarboxylase AM338_16575 ENOG4105CA0 peroxidase AM338_16580 ENOG4105E53 ec 3.2.1.28 AM338_16585 ENOG4106S2D Transcriptional regulator AM338_16590 ENOG4105CBN LysR family transcriptional regulator AM338_16595 ENOG4107H3J ribonuclease AM338_16600 ENOG4105CSH Transporter AM338_16605 ENOG41066T0 asmA family AM338_16610 ENOG4105CMB EAL domain-containing protein AM338_16620 ENOG4107SS6 2-dehydro-3-deoxygluconokinase AM338_16625 ENOG4105CS0 peptidase AM338_16645 ENOG4105BZU Histidine kinase AM338_16650 ENOG4105EJG cellulose synthase AM338_16655 ENOG4105K2Z endo-1,4-d-glucanase (EC 3.2.1.4) AM338_16660 ENOG4107EEX Cellulose synthase regulator protein AM338_16665 ENOG4107QZ7 Cellulose synthase catalytic subunit AM338_16675 ENOG410661M cytoplasmic protein AM338_16680 ENOG4105U74 cellulose biosynthesis protein BcsE AM338_16685 ENOG4105WQA Cellulose biosynthesis protein BcsF AM338_16690 ENOG4105D1V cellulose synthase operon protein YhjU AM338_16710 ENOG4105C44 Serine transporter AM338_16715 ENOG4108JQ7 (ABC) transporter AM338_16720 ENOG4105C3U ABC transporter AM338_16725 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component AM338_16730 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component AM338_16740 ENOG4105DEF Extracellular solute-binding protein, family 5 AM338_16760 ENOG4105DIJ Phosphoethanolamine transferase AM338_16765 ENOG4105FCD Major Facilitator AM338_16775 ENOG4105EAX Putative lipase AM338_16780 ENOG4108R3E Dna-3-methyladenine glycosylase i AM338_16785 ENOG4105HNP -acetyltransferase AM338_16790 ENOG4107QY8 reductase AM338_16795 ENOG4108ZG0 Ompa motb domain protein AM338_16805 ENOG4106JH6 (LipO)protein AM338_16810 ENOG4105MVF Transcriptional regulator AM338_16815 ENOG4105VEQ Cold shock protein AM338_16820 ENOG41060TC Hok gef cell toxic protein AM338_16835 ENOG4108HMW glycyl-tRNA synthetase, alpha subunit AM338_16840 ENOG4105RGS lipoprotein ysaB AM338_16845 ENOG4105MEV Acyl-transferase AM338_16850 ENOG4108Z12 YiaAB two helix domain-containing protein AM338_16855 ENOG410688U Inner membrane protein yiaB AM338_16860 ENOG4105CMG Carbohydrate kinase AM338_16870 ENOG4105DFW ABC transporter AM338_16875 ENOG4105C2J ABC transporter AM338_16880 ENOG4107RNG ABC transporter AM338_16885 ENOG4105T16 Transcriptional regulator (AraC family) AM338_16890 ENOG4108UR8 BAX protein AM338_16895 ENOG4107T9C Alpha amylase catalytic region AM338_16900 ENOG4105JKW Valine--pyruvate aminotransferase AM338_16905 ENOG4108XIB electron transport protein ysaA AM338_16910 ENOG4105J4Q Transcriptional regulator AM338_16920 ENOG4108R66 Conserved Protein AM338_16925 ENOG4105XDZ Tripartite ATP-independent periplasmic transporter AM338_16930 ENOG4105CG6 trap dicarboxylate transporter dctm subunit AM338_16935 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit AM338_16940 ENOG4105CMG Carbohydrate kinase AM338_16945 ENOG4105H6Q decarboxylase AM338_16950 ENOG41064BZ L-xylulose 5-phosphate 3-epimerase AM338_16955 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase AM338_16965 ENOG4105GNX MltA-interacting MipA family protein AM338_16970 ENOG4108Q2M Transcriptional regulator AM338_16975 ENOG4105EFX secretion protein, HlyD family AM338_16980 ENOG4105KK7 inner membrane protein YiaW AM338_16990 ENOG4105C26 Dehydrogenase AM338_16995 ENOG4105C0A alcohol dehydrogenase AM338_17000 ENOG4105EM7 Selenocysteine-specific translation elongation factor AM338_17010 ENOG4108U78 Glutathione S-transferase AM338_17015 ENOG4105CNA YD repeat protein AM338_17020 ENOG4105NUP lyase containing HEAT-repeat AM338_17065 ENOG4105EFX secretion protein, HlyD family AM338_17070 ENOG4105FP6 Protein of unknown function (DUF3302) AM338_17075 ENOG4105CTS PTS system mannitol-specific AM338_17085 ENOG4105E61 Mannitol repressor protein AM338_17095 ENOG4108YYI Protein of unknown function (DUF2810) AM338_17105 ENOG4105DAA L-lactate AM338_17110 ENOG41073TP transcriptional regulator AM338_17120 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) AM338_17125 ENOG4105D7W serine acetyltransferase AM338_17140 ENOG4105VW4 glutaredoxin 3 AM338_17145 ENOG4107YZP Rhodanese domain protein AM338_17160 ENOG41063SB peptidase AM338_17165 ENOG4105PXI polysaccharide deacetylase AM338_17170 ENOG4105K64 Glycosyl transferase, family 2 AM338_17180 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) AM338_17190 ENOG4105XA0 heptosyltransferase ii AM338_17195 ENOG4105D16 lipopolysaccharide heptosyltransferase i AM338_17200 ENOG4108FRV O-antigen ligase AM338_17205 ENOG4107XB0 Lipopolysaccharide 1,2-N-acetylglucosaminetransferase AM338_17210 ENOG4108QD8 lipopolysaccharide core biosynthesis protein AM338_17215 ENOG4108PDR lipopolysaccharide core biosynthesis protein AM338_17220 ENOG4105X1N Glycosyl transferase family 8 AM338_17225 ENOG4106AH0 Glycosyl Transferase AM338_17230 ENOG4107XU6 Glycosyl transferase (Group 1 AM338_17235 ENOG4105X1N Glycosyl transferase family 8 AM338_17240 ENOG4107543 (lipo)polysaccharide AM338_17245 ENOG4107RJ7 Glycosyl transferase (Group 1 AM338_17250 ENOG4105DKP glycosyl transferase, family 9 AM338_17255 ENOG4105D8A 3-Deoxy-D-manno-octulosonic-acid transferase AM338_17270 ENOG4105W0E 50S ribosomal protein L33 AM338_17285 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase AM338_17315 ENOG4105DSJ YicC domain protein AM338_17325 ENOG4105F5P DNA-damage-inducible protein d AM338_17330 ENOG4105EN6 Membrane AM338_17335 ENOG410649J Catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction (By similarity) AM338_17340 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) AM338_17345 ENOG4105VFG Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) AM338_17350 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) AM338_17355 ENOG4105FE8 tRNA (Guanosine-2'-O-)-methyltransferase AM338_17360 ENOG4105CB5 ATP-dependent DNA helicase recG AM338_17365 ENOG4105D6U Sodium Glutamate Symporter AM338_17370 ENOG4105C2W permease AM338_17375 ENOG4105JV1 AsmA family AM338_17380 ENOG4105CJQ hydrolase, family 31 AM338_17385 ENOG4105CT4 transporter AM338_17400 ENOG4105S8Q sugar efflux transporter AM338_17405 ENOG4108UZ3 Transporter AM338_17410 ENOG4105D01 (LipO)protein AM338_17420 ENOG4105T8A Uncharacterized protein YicS AM338_17435 ENOG4108SAJ Protein of unknown function (DUF1198) AM338_17440 ENOG4105C7N Xanthine uracil vitamin C permease AM338_17450 ENOG4105CXY transporter AM338_17455 ENOG4105CXY transporter AM338_17460 ENOG4105BZU Histidine kinase AM338_17465 ENOG4108KX4 response regulator AM338_17470 ENOG4105M71 acetolactate synthase 1 regulatory subunit AM338_17475 ENOG4105C7K acetolactate synthase AM338_17520 ENOG4105E5M Multidrug resistance protein D AM338_17525 ENOG4105J13 transcriptional regulator AM338_17530 ENOG4105JP4 Inner membrane protein yidG AM338_17535 ENOG4105VG5 Membrane AM338_17540 ENOG4106DRA Inner membrane protein YidI AM338_17545 ENOG4105CBG Sulfatase AM338_17550 ENOG4107RUZ Sss sodium solute transporter superfamily AM338_17555 ENOG4108AHD Transcriptional regulator AM338_17565 ENOG4105CI1 PTS System AM338_17570 ENOG4105FDP GntR family transcriptional regulator AM338_17590 ENOG4105R2A (LipO)protein AM338_17595 ENOG4105D99 atp gtp-binding protein AM338_17600 ENOG4107WAP fad NAD(P)-binding domain AM338_17605 ENOG4105DJB Major Facilitator Superfamily AM338_17615 ENOG4108RTU Aldolase AM338_17620 ENOG4105EI3 2-dehydro-3-deoxygalactonokinase EC 2.7.1.58 AM338_17625 ENOG4105EMF GntR family transcriptional regulator AM338_17630 ENOG410657R replicase EC 2.7 AM338_17635 ENOG410667J hydrolase AM338_17640 ENOG4105VP5 Bacterial protein of unknown function (DUF937) AM338_17645 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) AM338_17655 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) AM338_17705 ENOG4108P6C Tryptophan transporter of low affinity AM338_17720 ENOG4105E8Q phosphopantetheinyl transferase AM338_17725 ENOG4108YYH Nadph-dependent fmn reductase AM338_17730 ENOG4105C7N Xanthine uracil vitamin C permease AM338_17735 ENOG4107UB3 HAD-superfamily hydrolase subfamily IA variant 3 AM338_17740 ENOG4106HGK Inner membrane protein yieI AM338_17755 ENOG4108YXQ IS66 Orf2 family protein AM338_17765 ENOG4106611 bacteriocin immunity AM338_17770 ENOG4107VKM 6-phosphogluconolactonase AM338_17785 ENOG4105CS2 ec 3.2.1.21 AM338_17790 ENOG4105C5Y PTS System AM338_17795 ENOG4105CID antiterminator AM338_17800 ENOG4108UTW Plays a role in the regulation of phosphate uptake AM338_17805 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) AM338_17810 ENOG4105E2Z phosphate ABC transporter (Permease AM338_17815 ENOG4105C8U phosphate abc transporter AM338_17820 ENOG4107QMV Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity) AM338_17825 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) AM338_17865 ENOG4105KY6 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) AM338_17875 ENOG4105GXX Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit I associates with the membrane and may be involved with cation translocation AM338_17890 ENOG4105QTB Flavodoxin AM338_17895 ENOG4108VVK transcriptional Regulator, AsnC AM338_17905 ENOG4105EV2 VWA domain protein interacting with AAA ATPase AM338_17920 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) AM338_17925 ENOG4105C2J ABC transporter AM338_17930 ENOG4105CNN ABC, transporter AM338_17935 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator AM338_17940 ENOG4108RVA ribokinase AM338_17945 ENOG4105ETE Transcriptional regulator (LacI family AM338_17950 ENOG4105C0R drug resistance transporter emrb qaca subfamily AM338_17955 ENOG4107EJG GntR family transcriptional regulator AM338_17995 ENOG4108WFC UPF0438 protein yifE AM338_18000 ENOG4105C0P Mg chelatase subunit ChlI AM338_18020 ENOG4105P3Y Acetolactate synthase 2 regulatory subunit AM338_18025 ENOG4105CM2 brancheD-chain amino acid aminotransferase AM338_18035 ENOG4105C7B Threonine dehydratase AM338_18040 ENOG4105EMY transcriptional regulator AM338_18050 ENOG4105KQ5 peptidylprolyl cis-trans isomerase AM338_18060 ENOG4105C4R Atp-dependent dna helicase AM338_18065 ENOG4105C9X ppx gppa phosphatase AM338_18080 ENOG4105K63 Thioredoxin AM338_18100 ENOG4105ESV Glycosyl transferase, family 4 AM338_18105 ENOG4105SFE lipopolysaccharide biosynthesis protein AM338_18110 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase AM338_18115 ENOG4108IJ1 Dehydrogenase AM338_18120 ENOG4105C1B dTDP-glucose 4-6-dehydratase AM338_18125 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) AM338_18130 ENOG4108WJ1 acetyltransferase AM338_18135 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase AM338_18140 ENOG4105EGZ biosynthesis protein AM338_18145 ENOG4105F18 Catalyzes the synthesis of Und-PP-GlcNAc-ManNAcA-Fuc4NAc (Lipid III), the third lipid-linked intermediate involved in ECA synthesis (By similarity) AM338_18160 ENOG4105C85 amino acid AM338_18185 ENOG4105C4X radical SAM domain protein AM338_18190 ENOG4105ENH Sulfatase AM338_18195 ENOG410601J HemY protein AM338_18200 ENOG4105ECF c-methyltransferase AM338_18205 ENOG41076E6 Uroporphyrinogen-III Synthase AM338_18220 ENOG4107T0K Adenylate cyclase AM338_18235 ENOG4105S7Z (LipO)protein AM338_18245 ENOG4105CT0 Protein of unknown function, DUF484 AM338_18255 ENOG4105DFC had-superfamily hydrolase, subfamily ia, variant AM338_18260 ENOG4105C4R Atp-dependent dna helicase AM338_18265 ENOG4108T58 Mg2 transport protein CorA AM338_18270 ENOG4107QUT magnesium and cobalt transport protein CorA AM338_18275 ENOG4105NRM Membrane AM338_18280 ENOG4106WR8 Inner membrane protein YigG AM338_18285 ENOG4105FR1 rard protein AM338_18290 ENOG4108VUY thioesterase Superfamily protein AM338_18295 ENOG4105HDD phospholipase AM338_18300 ENOG4105C9U ATP-dependent DNA helicase RecQ AM338_18315 ENOG4108EUD Lysophospholipase AM338_18320 ENOG4105DQF Hydrolase AM338_18325 ENOG4105EMK carboxylate amino acid amine transporter AM338_18330 ENOG4105DZ2 Transcriptional regulator AM338_18335 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) AM338_18340 ENOG4105CDZ Carboxymethylenebutenolidase (EC 3.1.1.45) AM338_18345 ENOG4108I5U Uridine phosphorylase AM338_18355 ENOG4105CGY Dna recombination protein AM338_18365 ENOG4105JC1 sterol-binding domain protein AM338_18375 ENOG4105WKS Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) AM338_18380 ENOG4105X8U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity) AM338_18385 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) AM338_18390 ENOG4105F8V Hydrolase, tatD family AM338_18395 ENOG4105MDZ Transcriptional activator rfaH AM338_18400 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) AM338_18405 ENOG4107QK7 reductase AM338_18410 ENOG4105CHU acetyl-coa acetyltransferase AM338_18425 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein AM338_18430 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) AM338_18435 ENOG4108RR8 protoporphyrinogen oxidase AM338_18465 ENOG4105FNP Molybdopterin-guanine dinucleotide biosynthesis protein b AM338_18470 ENOG4105C6R Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) AM338_18475 ENOG4105PC1 Conserved Protein AM338_18480 ENOG4105E27 serine threonine protein kinase AM338_18485 ENOG4108Z33 Thiol disulfide Interchange Protein AM338_18495 ENOG4106HNH Acyl-transferase AM338_18505 ENOG4105C2M dna polymerase I AM338_18525 ENOG4105D4P Coproporphyrinogen iii oxidase AM338_18530 ENOG4106FIY AM338_18535 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family AM338_18540 ENOG4105CUX Signal transduction histidine kinase AM338_18545 ENOG4105C5F glutamine synthetase AM338_18560 ENOG4108K85 Transcriptional regulator AM338_18565 ENOG4108KHF Resistance protein AM338_18570 ENOG4105R9B Major Facilitator AM338_18575 ENOG4108KUC Outer membrane channel protein that allows an efficient diffusion of low-molecular-weight solutes such as small sugars and tetraglycine. However, the specific substrate recognized by the OmpL channel is AM338_18580 ENOG4105CT4 transporter AM338_18585 ENOG4105CT4 transporter AM338_18590 ENOG4105CJQ hydrolase, family 31 AM338_18595 ENOG4107WI4 Aldose-1-epimerase AM338_18600 ENOG4107QKS N-acylglucosamine 2-epimerase AM338_18605 ENOG4105D2M Aldolase AM338_18610 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase AM338_18615 ENOG4108MGF sugar kinase AM338_18620 ENOG4105E98 transcriptional regulator DeoR family AM338_18625 ENOG4105EJU HAD-superfamily hydrolase subfamily IA variant 3 AM338_18640 ENOG4105SUU thioesterase domain AM338_18645 ENOG4106UEE Transcriptional regulator AM338_18650 ENOG41068KX affects formate dehydrogenase-N AM338_18660 ENOG4108MG3 formate dehydrogenase AM338_18665 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein AM338_18685 ENOG4108V87 frv operon regulatory protein AM338_18690 ENOG4106C3V frv operon regulatory protein AM338_18695 ENOG4105CN9 Peptidase m42 family protein AM338_18700 ENOG4105DM4 PTS System AM338_18705 ENOG41064BA PTS system, fructose-specific, IIA component AM338_18745 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) AM338_18760 ENOG4108RPX mosc domain containing protein AM338_18765 ENOG4105E0F Histidine kinase AM338_18770 ENOG4105E3W Two component transcriptional regulator (Winged helix family AM338_18775 ENOG4105FMW periplasmic AM338_18790 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein AM338_18810 ENOG4105EBK exported protein AM338_18815 ENOG4108VTS Membrane AM338_18820 ENOG41065TG regulatoR AM338_18830 ENOG4105DP0 ferredoxin-NADP reductase AM338_18835 ENOG4105CBT Fructose-1,6-bisphosphatase AM338_18845 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) AM338_18860 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase AM338_18865 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) AM338_18875 ENOG41063M6 Cell Division Protein AM338_18880 ENOG4105ETE Transcriptional regulator (LacI family AM338_18885 ENOG4105C25 Primosomal protein n' AM338_18895 ENOG4107S01 Repressor protein MetJ AM338_18905 ENOG4105C28 cystathionine AM338_18910 ENOG4105CFH Aspartokinase AM338_18915 ENOG4105SYT Methylenetetrahydrofolate reductase AM338_18920 ENOG4105C1X Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity (By similarity) AM338_18925 ENOG4108Q5Y Membrane AM338_18930 ENOG4108XC3 NADH ubiquinone oxidoreductase AM338_18935 ENOG4105DCT glycerol dehydrogenase AM338_18940 ENOG4107T9Z Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) AM338_18945 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) AM338_18950 ENOG4105DM4 PTS System AM338_18955 ENOG4108YRF PTS System AM338_18960 ENOG4105C6N Formate acetyltransferase AM338_18965 ENOG4108AHH pyruvate formate lyase II activase AM338_18970 ENOG4108XCZ PTS System AM338_18975 ENOG4106R3P AraC family transcriptional regulator AM338_18980 ENOG4105DIJ Phosphoethanolamine transferase AM338_19000 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase AM338_19005 ENOG4105CAS nag kinase AM338_19015 ENOG4105C5Q Transcriptional regulator AM338_19035 ENOG4108Y73 Membrane AM338_19045 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) AM338_19075 ENOG4105D4A Cell wall formation (By similarity) AM338_19080 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase AM338_19125 ENOG4105PM1 preprotein translocase subunit SecE AM338_19130 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) AM338_19170 ENOG410645W Thiamin biosynthesis protein ThiH AM338_19175 ENOG4105D41 biosynthesis protein thiH AM338_19185 ENOG4105WHD thiamine biosynthesis protein ThiS AM338_19190 ENOG4105D06 uba thif-type nad fad binding protein AM338_19225 ENOG4105R2J Conserved Protein AM338_19230 ENOG4105K70 DNA-binding protein AM338_19235 ENOG4108T8B Protein of unknown function (DUF1481) AM338_19240 ENOG4105JBU Binds zinc. Could be an important component of the zinc- balancing mechanism AM338_19250 ENOG4105BZU Histidine kinase AM338_19255 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family AM338_19260 ENOG4105C12 Phosphoribosylglycinamide synthetase AM338_19295 ENOG41062WK cellular response to acidity AM338_19300 ENOG4105K5X acetyltransferase AM338_19305 ENOG4105CVG Homoserine O-transsuccinylase AM338_19310 ENOG4107QP3 malate synthase g AM338_19315 ENOG4108I9X Isocitrate lyase AM338_19330 ENOG41069M3 Transcriptional regulator AM338_19335 ENOG4105C3R Methionine synthase AM338_19340 ENOG4105EAM Na Pi-cotransporter AM338_19350 ENOG4105FE9 pseudouridine synthase AM338_19355 ENOG4108ZR5 Conserved Protein AM338_19360 ENOG4105CFH Aspartokinase AM338_19385 ENOG4108MDC (LipO)protein AM338_19390 ENOG4108Q9C Periplasmic Protein AM338_19395 ENOG4105E3R (LipO)protein AM338_19410 ENOG4107QNK )-transporter AM338_19415 ENOG4105EG2 ABC transporter, permease AM338_19420 ENOG4105D56 permease protein AM338_19425 ENOG4107FKK extracellular solute-binding protein family 1 AM338_19435 ENOG4108IJ9 (ABC) transporter AM338_19445 ENOG4107W52 maltose operon periplasmic protein AM338_19480 ENOG41080IJ Diacylglycerol kinase AM338_19490 ENOG4107R73 Mate efflux family protein AM338_19495 ENOG4105VDW Csbd family AM338_19500 ENOG4105MYN Zinc uptake regulation protein AM338_19515 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) AM338_19550 ENOG41077V0 CPS-53 (KpLE1) prophage AM338_19555 ENOG4108R7K Metal Dependent Phosphohydrolase AM338_19585 ENOG4108S1U AM338_19595 ENOG4105YQ0 AM338_19605 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) AM338_19610 ENOG4106CZA Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC (By similarity) AM338_19620 ENOG4108MXB Protein of unknown function (DUF968) AM338_19630 ENOG4105NI8 Cytosine-specific methyltransferase AM338_19655 ENOG4105QFS Lysis protein S homolog from lambdoid prophage AM338_19660 ENOG4105KUS lysozyme AM338_19665 ENOG4105SZK Rz endopeptidase from lambdoid prophage DLP12 AM338_19705 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) AM338_19780 ENOG4108X9F tail fiber protein AM338_19785 ENOG4105UZW Tail fiber assembly protein AM338_19790 ENOG4106FE3 DNA repair AM338_19800 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) AM338_19805 ENOG4105P4Z Phage shock protein G AM338_19810 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein AM338_19815 ENOG4105CDU Replicative dna helicase AM338_19820 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) AM338_19825 ENOG4105CGF Aromatic amino acid aminotransferase AM338_19835 ENOG4105F0S class B acid phosphatase AM338_19840 ENOG4108YXI Secondary thiamine-phosphate synthase enzyme AM338_19845 ENOG4105MSB protein, conserved in bacteria AM338_19850 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) AM338_19860 ENOG4108UUM single-stranded DNA-binding protein AM338_19865 ENOG4108FPN Integrase AM338_19900 ENOG4105PMV Membrane AM338_19910 ENOG4108M8H domain protein AM338_19915 ENOG4108W3Q Transcriptional regulator AM338_19920 ENOG4108Z4X TRANSCRIPTIONal AM338_19940 ENOG4105C7N Xanthine uracil vitamin C permease AM338_19945 ENOG4105EEQ Na H antiporter AM338_19960 ENOG41062QD Membrane AM338_19965 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) AM338_19980 ENOG4105JJ8 Cytochrome c nitrite reductase, pentaheme subunit AM338_19985 ENOG4105D3S 4Fe-4S Ferredoxin, iron-sulfur binding domain protein AM338_19990 ENOG4105DVI reductase, NrfD AM338_19995 ENOG4108QKW cytochrome c-type biogenesis protein AM338_20005 ENOG4108W0S formate-dependent nitrite reductase complex AM338_20015 ENOG4105CK2 sodium dicarboxylate symporter AM338_20020 ENOG41082ND Uncharacterized protein yjcO AM338_20030 ENOG4105ETP RND efflux system, outer membrane lipoprotein AM338_20035 ENOG4108MI0 Resistance protein AM338_20040 ENOG4105J12 Multidrug resistance protein mdtN AM338_20045 ENOG4106833 AM338_20050 ENOG4105EUZ Beta-lactamase domain protein AM338_20055 ENOG4107TFG D-allose kinase AM338_20060 ENOG4105UP7 3-epimerase AM338_20065 ENOG4105CNN ABC, transporter AM338_20070 ENOG4105C2J ABC transporter AM338_20075 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator AM338_20080 ENOG4105NYY transcriptional regulator, RpiR AM338_20090 ENOG4108YZG isomerase AM338_20095 ENOG4106ZVZ Escherichia coli IMT2125 genomic chromosome, IMT2125 AM338_20100 ENOG4107SA6 carbon-phosphorus lyase complex accessory protein AM338_20105 ENOG410849A acetyltransferase, (GNAT) family AM338_20110 ENOG4105MFQ Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP) (By similarity) AM338_20115 ENOG4105FD8 phosphonate metabolism protein PhnM AM338_20120 ENOG4105HRV phosphonate c-p lyase system protein phnl AM338_20125 ENOG4105ENV phosphonate C-P lyase system protein PhnK AM338_20130 ENOG4105FT8 Phosphonate metabolism AM338_20135 ENOG4105EKV Phosphonate metabolism protein AM338_20140 ENOG4105KZ6 phosphonate C-P lyase system protein PhnH AM338_20145 ENOG4105KQZ Phosphonate C-P lyase system protein PhnG AM338_20150 ENOG4107RJJ Transcriptional regulator AM338_20160 ENOG4105EHI Phosphonate ABC transporter, periplasmic AM338_20165 ENOG4105D5T phosphonate abc transporter AM338_20170 ENOG4108SQ4 Glyoxalase Bleomycin resistance protein (Dioxygenase AM338_20175 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA AM338_20190 ENOG4108YIV AM338_20195 ENOG4105CSH Transporter AM338_20205 ENOG4105ECM Sensor protein basS pmrB AM338_20210 ENOG4105XJC Two component transcriptional regulator (Winged helix family AM338_20215 ENOG4105DIJ Phosphoethanolamine transferase AM338_20220 ENOG4105D5Q Arginine ornithine antiporter AM338_20225 ENOG4106ZGR Transcriptional regulator AM338_20230 ENOG4105CXN decarboxylase AM338_20235 ENOG4108K2B transcriptional regulator AM338_20240 ENOG4105F8D glycoside hydrolase family 4 AM338_20245 ENOG4105CT4 transporter AM338_20250 ENOG4108R5S membrane AM338_20255 ENOG4107GFK fumarate AM338_20260 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter AM338_20270 ENOG4108MRH transcriptional regulatory protein AM338_20275 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism AM338_20280 ENOG4105VR1 Pfam:DUF1271 AM338_20285 ENOG410830R acetyltransferase AM338_20305 ENOG4105CRK lysyL-tRNA synthetase AM338_20310 ENOG4105DUX Transporter AM338_20315 ENOG4105CXN decarboxylase AM338_20320 ENOG4105D5Q Arginine ornithine antiporter AM338_20325 ENOG4108M3R transcriptional activator CadC AM338_20340 ENOG4108SIC Transcriptional regulator AM338_20345 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) AM338_20355 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter AM338_20360 ENOG4108IJ0 Aspartate ammonia-lyase AM338_20365 ENOG4108YH1 overproduction of this protein in Escherichia coli inhibits the F plasmid-mediated exclusion of bacteriophage T7 AM338_20370 ENOG4105DVH amino acid AM338_20385 ENOG4108ZVF (LipO)protein AM338_20390 ENOG4105MTB Uncharacterized protein YjeJ AM338_20395 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein AM338_20405 ENOG4106HKS Entericidin EcnA/B family AM338_20410 ENOG4106BSU Entericidin B AM338_20415 ENOG4105KPY Small multidrug resistance protein AM338_20420 ENOG4105QNF Outer membrane lipoprotein AM338_20425 ENOG41066YJ Beta-lactamase AM338_20440 ENOG4105E33 succinate dehydrogenase AM338_20445 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) AM338_20450 ENOG4105CAP With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P (By similarity) AM338_20455 ENOG4107SC7 Inner membrane transporter yjeM AM338_20460 ENOG4106V5W AM338_20465 ENOG4106CG8 Inner membrane protein YjeO AM338_20470 ENOG4105EGS Mechanosensitive ion channel AM338_20510 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) AM338_20515 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) AM338_20520 ENOG4105K8N protein family UPF0079, ATPase AM338_20525 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase AM338_20540 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) AM338_20545 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) AM338_20550 ENOG4107QJR hflk protein AM338_20555 ENOG4105EPW hflc protein AM338_20575 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) AM338_20580 ENOG4105C2N RNA methyltransferase TrmH family group 3 AM338_20585 ENOG4107HP6 Transcriptional regulator AM338_20590 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) AM338_20595 ENOG4105CSP Major Facilitator Superfamily AM338_20600 ENOG4105CTX dehydratase AM338_20615 ENOG4107VNS Protein of unknown function (DUF2491) AM338_20620 ENOG4105Z6B inner membrane protein yjfl AM338_20625 ENOG4108KXT Conserved Protein AM338_20630 ENOG4106032 Glutathionylspermidine synthase AM338_20635 ENOG4105CSU acyl-Coa dehydrogenase AM338_20645 ENOG4105S17 UPF0379 protein yjfN AM338_20650 ENOG4105WSB biofilm stress and motility protein A AM338_20655 ENOG4108MXZ Esterase AM338_20675 ENOG410907W The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in ascorbate transport AM338_20680 ENOG4106ETB IIa component AM338_20695 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase AM338_20700 ENOG4105R3P Inner membrane protein yagU AM338_20705 ENOG4105KIT UPF0379 protein yjfY AM338_20720 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) AM338_20740 ENOG4108RS6 transposase AM338_20745 ENOG4105D7V transposase AM338_20755 ENOG4105FHY Opacity-associated protein A AM338_20765 ENOG4108V1T peptidylprolyl cis-trans isomerase AM338_20770 ENOG4105C85 amino acid AM338_20780 ENOG4105DXC membrane AM338_20785 ENOG4105ECR NmrA family AM338_20790 ENOG4105KVH Transcriptional regulator AM338_20795 ENOG4107RNS bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase 3'-nucleotidase periplasmic AM338_20800 ENOG4108RNI 3'(2')5'-bisphosphate nucleotidase AM338_20815 ENOG4108UUE Transcriptional regulator AM338_20820 ENOG41061GZ Protein of unknown function (DUF1107) AM338_20825 ENOG4105C37 (CBS) domain AM338_20840 ENOG4105CFU surface antigen AM338_20845 ENOG4105MA0 exported protein AM338_20850 ENOG4108ZHD aig2 family AM338_20855 ENOG41087RY SpoVT_AbrB AM338_20860 ENOG4105MZG transcriptional modulator of maze toxin, mazf AM338_20865 ENOG4105F0N pyrophosphate phospho-hydrolase AM338_20870 ENOG4107R5U Periplasmic binding protein LacI transcriptional regulator AM338_20875 ENOG4105C2J ABC transporter AM338_20880 ENOG4107R9N ABC transporter AM338_20885 ENOG41062B0 ABC transporter, permease AM338_20895 ENOG4105DFU Cell wall formation (By similarity) AM338_20905 ENOG4105CMS peptidase U62, modulator of DNA gyrase AM338_20915 ENOG4108RDD Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine (By similarity) AM338_20920 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase AM338_20925 ENOG4105CG3 alpha amylase, catalytic region AM338_20930 ENOG4105C5Y PTS System AM338_20935 ENOG4105D4X repressor AM338_20940 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic AM338_20945 ENOG4105KME endoribonuclease L-psp AM338_20960 ENOG41077AM PyrBI operon attenuator AM338_20970 ENOG4108UQ8 endoribonuclease L-psp AM338_20975 ENOG4105F6U Short-chain dehydrogenase reductase Sdr AM338_20980 ENOG4108XFH Transcriptional regulator AM338_20985 ENOG4105XEP YhcH YjgK YiaL family protein AM338_21000 ENOG4105KQT Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome (By similarity) AM338_21005 ENOG4108MJ3 acetyltransferase AM338_21010 ENOG4108M3P Membrane AM338_21015 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) AM338_21020 ENOG4105MYG DNA polymerase iii, chi subunit AM338_21030 ENOG4108M8S permease YjgP YjgQ family protein AM338_21035 ENOG4108K5H permease YjgP YjgQ family protein AM338_21040 ENOG4105D7A ATP-binding protein AM338_21045 ENOG4105DQ4 alcohol dehydrogenase AM338_21120 ENOG4107RRE RNA-directed DNA polymerase AM338_21135 ENOG4105EKQ RNA-directed DNA polymerase AM338_21155 ENOG4108WUH Transcriptional regulator, TetR family AM338_21165 ENOG4105EXU Membrane AM338_21175 ENOG4105C94 Transporter AM338_21185 ENOG4105NWR lipid A biosynthesis (Kdo)2-(Lauroyl)-lipid IVA acyltransferase AM338_21190 ENOG4108MJ5 VirK protein AM338_21195 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) AM338_21200 ENOG4107BJW polysaccharide deacetylase AM338_21215 ENOG4105EKQ RNA-directed DNA polymerase AM338_21230 ENOG4105E0A ABC, transporter AM338_21235 ENOG4108IHU transport system permease protein AM338_21240 ENOG4105DQ5 transport system permease protein AM338_21245 ENOG4108HUF Transporter AM338_21250 ENOG4105GAV receptor AM338_21255 ENOG4108S3W Anti-feci sigma factor, fecr AM338_21260 ENOG4108SF5 RNA Polymerase AM338_21300 ENOG4105E5H Transposase AM338_21305 ENOG4108YXQ IS66 Orf2 family protein AM338_21335 ENOG41069FU Outer membrane channel protein allowing the entry of N- acetylneuraminic acid (Neu5Ac, the most abundant sialic acid on host cell surfaces) into the bacteria AM338_21360 ENOG4107EFN gluconate transport system permease 3 AM338_21375 ENOG4105DEI Mannitol dehydrogenase AM338_21385 ENOG4105C6F GntR Family Transcriptional Regulator AM338_21405 ENOG4107YNJ LysR family Transcriptional regulator AM338_21410 ENOG4105DYB Isoaspartyl dipeptidase AM338_21415 ENOG4108P2H Inner membrane protein YjiG AM338_21420 ENOG41074DU domain protein AM338_21430 ENOG4105CBP Major Facilitator AM338_21445 ENOG4105CIZ coA-substrate-specific enzyme activase AM338_21450 ENOG4105DCU 2-hydroxyglutaryl-CoA dehydratase AM338_21455 ENOG4106BRA Membrane AM338_21460 ENOG41083G8 Multidrug resistance protein MdtM AM338_21480 ENOG4105CKI cobalamin synthesis protein AM338_21485 ENOG4105VCD cytoplasmic protein AM338_21490 ENOG4105D22 carbon starvation protein AM338_21500 ENOG4105C8Q Methyl-accepting chemotaxis AM338_21505 ENOG4108I5G Major Facilitator superfamily AM338_21510 ENOG410617M Transcriptional regulator AM338_21515 ENOG4105CPQ Dehydrogenase AM338_21525 ENOG4105RI1 glycoprotein receptor AM338_21530 ENOG4106CVF DNA replication protein AM338_21545 ENOG4105DWK Membrane AM338_21550 ENOG4108N8T regulatoR AM338_21555 ENOG4108T94 DNA-binding transcriptional activator BglJ AM338_21560 ENOG4108819 ferric iron reductase AM338_21565 ENOG4105YBH Protein of unknown function (DUF1435) AM338_21585 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) AM338_21590 ENOG4108WPU DNA polymerase III subunit psi AM338_21595 ENOG4105KEG ribosomal-protein-alanine acetyltransferase AM338_21600 ENOG4105PAD Hydrolase AM338_21610 ENOG4105K3G Periplasmic Protein AM338_21620 ENOG4108NRW Phospholipase, patatin family AM338_21625 ENOG4105EYA deoxyribonuclease AM338_21630 ENOG41076CZ activating enzyme AM338_21635 ENOG4105G0K glycine radical enzyme YjjI family AM338_21665 ENOG4107RMF Catalyzes both the ATP-dependent activation of exogenously supplied lipoate to lipoyl-AMP and the transfer of the activated lipoyl onto the lipoyl domains of lipoate-dependent enzymes (By similarity) AM338_21670 ENOG4105EAC phosphoserine phosphatase AM338_21675 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) AM338_21680 ENOG4107VZS Nicotinamide-nucleotide adenylyltransferase AM338_21685 ENOG4105C5H ABC transporter AM338_21695 ENOG4107SC1 transglycosylase AM338_21715 ENOG4105UEI Transcriptional Regulator AraC Family AM338_21720 ENOG4108RH0 Crea protein AM338_21725 ENOG4105E3W Two component transcriptional regulator (Winged helix family AM338_21730 ENOG4105EB3 Histidine kinase AM338_21735 ENOG4105CT7 inner membrane cred family protein AM338_21740 ENOG41065U4 response regulator AM338_21745 ENOG410759A AM338_21750 ENOG4106FVC RNA methyltransferase AM338_21760 ENOG4105CFH Aspartokinase AM338_21770 ENOG4105D98 threonine synthase AM338_21775 ENOG41062C6 Protein of unknown function (DUF2502) AM338_21780 ENOG4105D1Q UPF0246 protein AM338_21785 ENOG4105BZG amino acid carrier protein AM338_21795 ENOG4108RIR Molybdenum cofactor biosynthesis protein AM338_21800 ENOG4106HK8 GPR1 FUN34 yaaH family protein AM338_21805 ENOG4108QUJ UPF0174 protein YaaW AM338_21825 ENOG4108SER Transposase AM338_21830 ENOG4105WI6 cell killing protein encoded within cryptic prophage AM338_21845 ENOG41063Z6 transcriptional regulator, lysR family AM338_21870 ENOG410647N response to DNA damage stimulus AM338_21875 ENOG4105DTN riboflavin biosynthesis protein ribF AM338_21880 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) AM338_21890 ENOG41090X3 Peptidyl-prolyl cis-trans isomerase AM338_21915 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain AM338_21920 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain AM338_21930 ENOG4108XNW Transcriptional activatory protein CaiF AM338_21940 ENOG4106YT9 Enoyl-CoA hydratase AM338_21975 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase AM338_21980 ENOG4105IBM Could be part of an electron transfer system required for anaerobic carnitine reduction. Could be a 3Fe-4S cluster- containing protein AM338_21985 ENOG4105C54 Major Facilitator superfamily AM338_22000 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) AM338_22025 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) AM338_22030 ENOG4105E7H involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity) AM338_22035 ENOG41066UG Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host (By similarity) AM338_22045 ENOG4105D3G Pseudouridine synthase AM338_22055 ENOG4105CQ2 DNA polymerase AM338_22060 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase AM338_22065 ENOG4105CAC Catalyzes the conversion of L-arabinose to L-ribulose (By similarity) AM338_22070 ENOG4105EF1 ribulokinase AM338_22080 ENOG41063TF transcriptional regulator (AraC AM338_22085 ENOG4108KF1 Membrane AM338_22090 ENOG4107T0D ABC, transporter AM338_22095 ENOG4106SMU thiamine transporter membrane protein AM338_22100 ENOG4105DP9 ABC transporter AM338_22105 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) AM338_22115 ENOG4105S8Q sugar efflux transporter AM338_22130 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) AM338_22145 ENOG41064T2 transcriptional regulator, lysR family AM338_22150 ENOG4105C7K acetolactate synthase AM338_22155 ENOG4108ZP8 Acetolactate synthase small subunit AM338_22165 ENOG4107B7Y DNA-binding transcriptional regulator FruR AM338_22175 ENOG4108V6E Cell division protein mraZ AM338_22185 ENOG41063Y6 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) AM338_22190 ENOG4105CJN penicillin-binding protein AM338_22195 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) AM338_22200 ENOG4108EQQ Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity) AM338_22210 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) AM338_22215 ENOG4105CNI cell division protein FtsW AM338_22230 ENOG4105CPF Cell wall formation (By similarity) AM338_22235 ENOG4105K7E Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity) AM338_22240 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) AM338_22245 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) AM338_22265 ENOG4105M6F mutator MutT protein AM338_22280 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) AM338_22290 ENOG4105D7Q type ii secretion system AM338_22295 ENOG4107QHF type ii secretion system protein e AM338_22300 ENOG4108ZUW Major pilin subunit AM338_22310 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase AM338_22315 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase AM338_22320 ENOG4106A72 regulatory protein AmpE AM338_22325 ENOG4105C85 amino acid AM338_22330 ENOG41073TP transcriptional regulator AM338_22340 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) AM338_22345 ENOG4107QSN dihydrolipoamide acetyltransferase AM338_22350 ENOG4107QN2 dihydrolipoyl dehydrogenase AM338_22355 ENOG4108NST exported protein AM338_22365 ENOG4107QIJ Aconitate hydratase 2 AM338_22385 ENOG4108ZRK uncharacterized protein yacC AM338_22390 ENOG4105E3B Multicopper oxidase AM338_22395 ENOG4105DZG Dehydrogenase AM338_22400 ENOG4108UGV hypoxanthine phosphoribosyltransferase AM338_22405 ENOG41077A9 carbonic anhydrase AM338_22410 ENOG4105DA5 (ABC) transporter AM338_22415 ENOG4105E3A (ABC) transporter AM338_22420 ENOG4108YTN IIa component AM338_22425 ENOG4107BJW polysaccharide deacetylase AM338_22445 ENOG4108A32 Transposase AM338_22460 ENOG4105P0Q fimbrial-like protein YadC AM338_22465 ENOG4105SN2 fimbrial-like adhesin protein AM338_22470 ENOG4105SYG Fimbrial protein AM338_22475 ENOG4108XEY fimbrial-like adhesin protein AM338_22480 ENOG4105CW0 outer membrane usher protein AM338_22485 ENOG4108VEV chaperone AM338_22495 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase AM338_22500 ENOG4105DJ0 Poly(A) Polymerase AM338_22510 ENOG4108V7X Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters AM338_22520 ENOG4107XID 2'-5' rna ligase AM338_22525 ENOG4105CQ7 ATP-dependent helicase AM338_22535 ENOG4105BZ4 penicillin-binding protein AM338_22540 ENOG4105E0K tonB-dependent siderophore receptor AM338_22545 ENOG4105E0A ABC, transporter AM338_22550 ENOG4105J76 Periplasmic binding protein AM338_22555 ENOG4105S6R Iron-hydroxamate transporter permease subunit AM338_22575 ENOG4105EN6 Membrane AM338_22580 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) AM338_22600 ENOG4105C0H protease AM338_22605 ENOG4108IXP Carbohydrate diacid transcriptional activator CdaR AM338_22615 ENOG4105DIN metallophosphoesterase AM338_22630 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) AM338_22665 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) AM338_22670 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) AM338_22675 ENOG4105KNE Phosphatidate cytidylyltransferase AM338_22680 ENOG4105DZP Membrane-associated zinc metalloprotease AM338_22690 ENOG4108RFI Molecular chaperone that interacts specifically with outer membrane proteins, thus maintaining the solubility of early folding intermediates during passage through the periplasm (By similarity) AM338_22695 ENOG4105D7M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) AM338_22720 ENOG4105C0B DNA polymerase III (alpha subunit) AM338_22730 ENOG4105CXN decarboxylase AM338_22735 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase AM338_22740 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) AM338_22745 ENOG4105M1T rho-binding antiterminator AM338_22755 ENOG4108VWS Yaeq family AM338_22760 ENOG4108YZN class I peptide chain release factor AM338_22765 ENOG4107EII Lipoprotein involved with copper homeostasis and adhesion AM338_22770 ENOG4108UY0 (LipO)protein AM338_22780 ENOG4108R96 Methyltransferase, YaeB family AM338_22785 ENOG4108R8X outer membrane lipoprotein AM338_22790 ENOG4105D01 (LipO)protein AM338_22795 ENOG4108UMI ABC transporter, permease AM338_22800 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) AM338_22805 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase AM338_22840 ENOG4105CV8 reductase AM338_22845 ENOG4105HEI LysR family (Transcriptional regulator AM338_22855 ENOG4105F2W methyltransferase AM338_22860 ENOG4105E9H Lytic Murein transglycosylase AM338_22865 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) AM338_22870 ENOG4105D1A Methyltransferase AM338_22880 ENOG4107RZZ dna polymerase iii epsilon subunit AM338_22890 ENOG410600K aminopeptidase AM338_22905 ENOG4105GMB type VI secretion system effector, hcp1 family AM338_22930 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit AM338_22985 ENOG4108WC9 type VI secretion system effector, hcp1 family AM338_22995 ENOG4105CS6 Rhs element vgr protein AM338_23010 ENOG410600T transposase AM338_23015 ENOG4105CZ7 nitrilase cyanide hydratase and apolipoprotein n-acyltransferase AM338_23020 ENOG4108WN0 inhibitor of vertebrate lysozyme AM338_23025 ENOG4107QPN acyl-Coa dehydrogenase AM338_23035 ENOG4105E7A Glutamine amidotransferase AM338_23040 ENOG4105F7V ErfK ybiS ycfS ynhG family protein AM338_23045 ENOG4105VXN addiction module toxin, RelE StbE family AM338_23050 ENOG4105QHH Antitoxin component of a toxin-antitoxin (TA) module. A labile antitoxin that counteracts the effect of the YafQ toxin. YafQ and DinJ together bind their own promoter, and by analogy to other TA modules probably repress its expression AM338_23055 ENOG4108YS0 lipoprotein YafL AM338_23060 ENOG4108UK5 Transposase AM338_23075 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) AM338_23080 ENOG4105UG9 Antitoxin of the YafO-YafN toxin-antitoxin system AM338_23085 ENOG41065DM this blockage is overcome by subsequent expression of antitoxin YafN. Overexpression causes cleavage of a number of mRNAs in a ribosome-dependent fashion. YafO binding to the 50S ribosomal subunit in the translation complex induces mRNA cleavage 3' to the region protected by the ribosome AM338_23090 ENOG4108HYG acetyltransferase AM338_23100 ENOG4108S2Y peptide Chain Release factor AM338_23105 ENOG4105CIN aminoacyl-histidine dipeptidase AM338_23125 ENOG4105FCK Membrane AM338_23145 ENOG4105DFP Integrase AM338_23190 ENOG4105YCT UPF0386 protein AM338_23205 ENOG4105K34 Involved in the degradation of phospho-AI-2, thereby terminating induction of the lsr operon and closing the AI-2 signaling cycle. Catalyzes the cleavage of phosphorylated 4,5- dihydroxy-2,3-pentanedione (P-DPD) to 2-phosphoglycolic acid (PG) and another three-carbon compound AM338_23215 ENOG4105D4B ABC, transporter AM338_23220 ENOG4105F5R ABC transporter AM338_23225 ENOG41071MT Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane AM338_23230 ENOG4105C2J ABC transporter AM338_23240 ENOG4108EMV Catalyzes the phosphorylation of autoinducer 2 (AI-2) to phospho-AI-2, which subsequently inactivates the transcriptional regulator LsrR and leads to the transcription of the lsr operon. Phosphorylates the ring-open form of 4,5-dihydroxy-2,3- pentanedione (DPD), which is the precursor to all AI-2 signaling molecules, at the C5 position (By similarity) AM338_23265 ENOG4105EKQ RNA-directed DNA polymerase AM338_23295 ENOG4105E5H Transposase AM338_23300 ENOG4108YXQ IS66 Orf2 family protein AM338_23315 ENOG4105KF5 hemolysin expression-modulating protein AM338_23410 ENOG4108PZQ Inner membrane protein YeeR AM338_23425 ENOG4106H6R UPF0380 protein AM338_23435 ENOG4105MFG Antirestriction protein AM338_23440 ENOG4108YGG dna repair protein AM338_23445 ENOG4106WJE Protein of unknown function (DUF987) AM338_23455 ENOG4105MAW Antitoxin component of a toxin-antitoxin (TA) module. Labile antitoxin that counteracts the effect of the CbtA (YeeV) toxin. It does not bind to the cognate toxin but instead binds to MreB and FtsZ (the toxin targets), enhancing their polymerization by forming higher-order bundles AM338_23460 ENOG4108X3P Toxic component of a toxin-antitoxin (TA) module. Overexpression results in inhibition of growth in liquid cultures AM338_23470 ENOG4107XAN XdhC and CoxI family AM338_23475 ENOG4105C7W Xanthine dehydrogenase AM338_23480 ENOG4105DIP Molybdopterin dehydrogenase FAD-binding AM338_23485 ENOG4107XKX isoquinoline 1-oxidoreductase, alpha subunit AM338_23495 ENOG4105R3P Inner membrane protein yagU AM338_23505 ENOG4105PI0 Ferredoxin AM338_23510 ENOG4108UD7 cell wall organization AM338_23515 ENOG4106PYX Receptor AM338_23520 ENOG4108N3D putative enzyme AM338_23530 ENOG4108GWT fimbrillin MatB AM338_23535 ENOG4106JB4 Represses expression of the flagellar master operon flhDC, and consequently prevents flagellum biosynthesis and motility. Acts by binding to the regulatory region of the flhDC operon AM338_23555 ENOG4105NRA 50s ribosomal protein l31 type b AM338_23590 ENOG4108KBJ Inner membrane protein YkgB AM338_23595 ENOG41066GK UPF0379 protein ykgI AM338_23600 ENOG4107QN2 dihydrolipoyl dehydrogenase AM338_23605 ENOG4108K01 transcriptional regulator AM338_23610 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) AM338_23615 ENOG4107QR9 Iron-sulfur cluster binding protein AM338_23620 ENOG4108ZZK Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source (By similarity) AM338_23640 ENOG4105CZ6 Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine (By similarity) AM338_23645 ENOG4105C26 Dehydrogenase AM338_23650 ENOG4108MHR Repressor involved in choline regulation of the bet genes (By similarity) AM338_23660 ENOG4105C94 Transporter AM338_23675 ENOG4105BZU Histidine kinase AM338_23680 ENOG4108NUU Transcriptional regulator AM338_23685 ENOG4105SZ2 membrAne AM338_23695 ENOG4107SNB ankyrin repeat protein YahD AM338_23700 ENOG4105N16 Protein of unknown function (DUF2877) AM338_23705 ENOG4107R1Q Membrane protein FdrA AM338_23710 ENOG4107REC cytoplasmic protein AM338_23720 ENOG4105C5B carbamate kinase AM338_23725 ENOG4105DZC cytosine deaminase AM338_23730 ENOG4105DQ4 alcohol dehydrogenase AM338_23745 ENOG4105E82 cytochrome subunit of dehydrogenase AM338_23750 ENOG4105TDT uncharacterized protein yahO AM338_23755 ENOG4108JU7 Transcriptional regulator AM338_23760 ENOG4105CR4 methylisocitrate lyase AM338_23765 ENOG4105BZN citrate synthase AM338_23770 ENOG4105DXD 2-methylcitrate dehydratase AM338_23775 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) AM338_23780 ENOG4105DQW permease for cytosine purines, uracil, thiamine, allantoin AM338_23785 ENOG4105DZC cytosine deaminase AM338_23790 ENOG4105DND Transcriptional regulator AM338_23795 ENOG4107B2H carbonic anhydrase AM338_23800 ENOG4108V7B Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide (By similarity) AM338_23805 ENOG4105DJ2 Major Facilitator Superfamily AM338_23810 ENOG4108UW5 maltose o-acetyltransferase AM338_23815 ENOG4105U0F oligosaccharide H symporter, major facilitator superfamily (MFS) AM338_23820 ENOG4105CNT hydrolase family 2 AM338_23830 ENOG4105ETE Transcriptional regulator (LacI family AM338_23835 ENOG4108K2P TRANSCRIPTIONal AM338_23840 ENOG4105E2Q 3-(3-hydroxy-phenyl)propionate hydroxylase AM338_23845 ENOG4105MI0 Catalyzes the non-heme iron(II)-dependent oxidative cleavage of 2,3-dihydroxyphenylpropionic acid and 2,3- dihydroxicinnamic acid into 2-hydroxy-6-ketononadienedioate and 2- hydroxy-6-ketononatrienedioate, respectively (By similarity) AM338_23850 ENOG4106HB6 Alpha beta hydrolase AM338_23855 ENOG4105IKQ hydratase AM338_23870 ENOG4108SC4 )-transporter AM338_23875 ENOG4105IUQ nucleoprotein polynucleotide-associated enzyme AM338_23880 ENOG4105C4W S-formylglutathione hydrolase AM338_23895 ENOG4105SRB Uncharacterized protein yaiO AM338_23905 ENOG4108PBI Polysaccharide metabolism AM338_23910 ENOG4107W19 lmbE family AM338_23930 ENOG4106FTQ Taurine ABC transporter, periplasmic AM338_23935 ENOG4108IY8 ABC, transporter AM338_23940 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component AM338_23945 ENOG4105E2B Taurine dioxygenase AM338_23950 ENOG4105D52 delta-aminolevulinic acid dehydratase AM338_23965 ENOG4108PNB DNA-binding transcriptional regulator AM338_23970 ENOG4107R6D beta-lactam binding protein AmpH AM338_23980 ENOG4108DQG in Escherichia coli SbmA is involved in uptake of microcin J25 AM338_23985 ENOG4107QS8 (LipO)protein AM338_23990 ENOG4105FR5 inner membrane protein YaiY AM338_23995 ENOG4105UNH Membrane AM338_24000 ENOG4105CPF Cell wall formation (By similarity) AM338_24015 ENOG4105G6Z alkaline phosphatase AM338_24020 ENOG4105VIF phosphate starvation-inducible protein AM338_24025 ENOG4105BZU Histidine kinase AM338_24030 ENOG4105II7 pyrroline-5-carboxylate reductase AM338_24045 ENOG4105SS3 AM338_24055 ENOG4105HBA AroM protein AM338_24080 ENOG4105DKQ ROK family AM338_24085 ENOG4105F27 Major Facilitator AM338_24090 ENOG4105EYH Exonuclease AM338_24095 ENOG4107RH8 nuclease SbcCD subunit D AM338_24100 ENOG4105CK6 Two component transcriptional regulator (Winged helix family AM338_24105 ENOG4105BZU Histidine kinase AM338_24110 ENOG4105CWM branched-chain amino acid transport system II carrier protein AM338_24115 ENOG4105C85 amino acid AM338_24120 ENOG4107R28 alpha amylase, catalytic region AM338_24140 ENOG4105VIE preprotein translocase, subunit YajC AM338_24145 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) AM338_24150 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) AM338_24155 ENOG4105N1F Hnh endonuclease AM338_24160 ENOG4105DRB nucleoside-specific channel-forming protein AM338_24165 ENOG4108KIC (LipO)protein AM338_24175 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) AM338_24180 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) AM338_24190 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) AM338_24195 ENOG4108ZAI phosphatidylglycerophosphatase a AM338_24200 ENOG4105CPC Aldo Keto reductase AM338_24210 ENOG4105CTB Polyprenyl synthetase AM338_24225 ENOG4107S0N DJ-1 family AM338_24230 ENOG4108JZF Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) AM338_24240 ENOG4107RDB Major Facilitator AM338_24250 ENOG41090KH cytochrome o ubiquinol oxidase (subunit iv) AM338_24255 ENOG4105CCU oxidase (Subunit III) AM338_24260 ENOG4105BZ9 Cytochrome C oxidase, subunit I AM338_24265 ENOG4105E2S oxidase) subunit II AM338_24270 ENOG4105EYM Major Facilitator superfamily AM338_24275 ENOG4105IEY (LipO)protein AM338_24285 ENOG4105M85 Bola protein AM338_24310 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) AM338_24315 ENOG4105K70 DNA-binding protein AM338_24320 ENOG4105EIN peptidylprolyl cis-trans isomerase AM338_24325 ENOG41083P1 competence protein ComEA helix-hairpin-helix repeat protein AM338_24330 ENOG4108TGP Thioesterase superfamily protein AM338_24340 ENOG4108NFA extracellular solute-binding protein AM338_24350 ENOG4108XM1 transcriptional regulator AsnC family AM338_24355 ENOG4105BZ1 (ABC) transporter AM338_24360 ENOG4105BZ1 (ABC) transporter AM338_24365 ENOG4108YZA Nitrogen regulatory protein pii AM338_24370 ENOG4105BZU Histidine kinase AM338_24375 ENOG4105C29 acyl-CoA thioesterase AM338_24380 ENOG4108MNP Glycoprotein polysaccharide metabolism AM338_24385 ENOG41080UX Methyltransferase AM338_24395 ENOG4105KCV RNA signal recognition particle 4.5S RNA AM338_24400 ENOG41066DG (EAL) domain protein AM338_24405 ENOG4105GSJ Inner membrane protein ylaC AM338_24410 ENOG4108UW5 maltose o-acetyltransferase AM338_24415 ENOG4105KF5 hemolysin expression-modulating protein AM338_24420 ENOG4108UKR Biofilm formation regulator YbaJ AM338_24425 ENOG4105BZS acriflavin resistance protein AM338_24430 ENOG4105C1P efflux transporter, rnd family, mfp subunit AM338_24435 ENOG4108IG5 Transcriptional regulator AM338_24445 ENOG4105EGS Mechanosensitive ion channel AM338_24450 ENOG4106428 Protein of unknown function (DUF2496) AM338_24455 ENOG4108URS primosomal replication protein n'' AM338_24460 ENOG4105WD1 Membrane AM338_24475 ENOG4107QMP dna polymerase iii subunits gamma and tau AM338_24490 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) AM338_24515 ENOG4107RE1 Inosine-guanosine kinase AM338_24520 ENOG4105CKD glutathione-regulated potassium-efflux system protein AM338_24525 ENOG4105EU0 Major facilitator Superfamily AM338_24535 ENOG4105CGH 5'-nucleotidase AM338_24540 ENOG4108Z66 YbaK ebsC protein AM338_24550 ENOG4105MBR gumn family AM338_24560 ENOG41081XE plasmid maintenance system antidote protein, xre family AM338_24565 ENOG4105C59 p-type ATPase AM338_24570 ENOG4105CSV Glutaminase AM338_24575 ENOG4107RY6 amino acid AM338_24580 ENOG4108Z6Z Transcriptional regulator AM338_24585 ENOG4105G5H Membrane AM338_24590 ENOG4107QX8 SPFH domain, Band 7 family protein AM338_24595 ENOG41083J0 (ABC) transporter AM338_24600 ENOG4105C4B ABC transporter, permease AM338_24605 ENOG4107QR8 Thioredoxin AM338_24610 ENOG4105E1F short-chain dehydrogenase reductase AM338_24615 ENOG4108UJV acyl-CoA thioesterase i AM338_24620 ENOG4108I0Y (ABC) transporter AM338_24625 ENOG4105CV6 ABC transporter, permease AM338_24660 ENOG4107653 Transcriptional regulator AM338_24665 ENOG4108Z2U ureidoglycolate hydrolase AM338_24670 ENOG4108N16 Negative regulator of allantoin and glyoxylate utilization operons. Binds to the gcl promoter and to the allS- allA intergenic region AM338_24675 ENOG41060W2 glyoxylate carboligase AM338_24680 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) AM338_24685 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase AM338_24690 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease AM338_24700 ENOG4105DTE Xanthine uracil vitamin C permease AM338_24705 ENOG4105BZW Glycerate kinase AM338_24710 ENOG4105S0E allantoin catabolism protein AM338_24715 ENOG4105CE7 Amidase, hydantoinase carbamoylase family AM338_24720 ENOG4105DG4 malate L-lactate dehydrogenase AM338_24725 ENOG4107R1Q Membrane protein FdrA AM338_24730 ENOG4107REC cytoplasmic protein AM338_24735 ENOG4105G5A Protein of unknown function (DUF2877) AM338_24740 ENOG4105C5B carbamate kinase AM338_24745 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit AM338_24750 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) AM338_24765 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) AM338_24775 ENOG4105S2T inner membrane protein YbcI AM338_24780 ENOG4105WQ3 Rna-binding protein AM338_24790 ENOG4108WDE Fimbrial protein AM338_24795 ENOG4108AF8 Chaperone AM338_24800 ENOG4105CW0 outer membrane usher protein AM338_24805 ENOG4108M66 Involved in regulation of length and mediation of adhesion of SfmA fimbriae (but not necessary for the production of fimbriae). Seems to be mannose binding adhesin (By similarity) AM338_24810 ENOG4108ZI2 Fimbrial protein AM338_24815 ENOG4108Q9V regulatoR AM338_24995 ENOG41074AV Hok/gef family AM338_25095 ENOG4106JQ7 AM338_25100 ENOG41073YN Protein of unknown function (DUF1380) AM338_25130 ENOG4106JGA Chromosome (Plasmid) partitioning protein, ParB AM338_25135 ENOG4105EZN Cobyrinic acid ac-diamide synthase AM338_25150 ENOG4105PPN plasmid maintenance protein, CcdB AM338_25155 ENOG4105XY2 plasmid maintenance protein CcdA AM338_25175 ENOG4105M0J Toxic component of a toxin-antitoxin (TA) module. A AM338_25180 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) AM338_25215 ENOG4105F1Y L-lysine 6-monooxygenase (NADPH) AM338_25220 ENOG4105DUU IucA IucC family protein AM338_25240 ENOG41082CG Protein CrcB homolog AM338_25250 ENOG4105C70 Catalyzes the reversible conversion of 2- phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis (By similarity) AM338_25260 ENOG4105CC5 ABC transporter AM338_25265 ENOG4105CC5 ABC transporter AM338_25270 ENOG4105DIK (ABC) transporter AM338_25315 ENOG4106JVB Replication Protein AM338_25350 ENOG4107ENK receptor AM338_25380 ENOG4108YXQ IS66 Orf2 family protein AM338_25420 ENOG4105I1F Resistance protein AM338_25495 ENOG4105N2G alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen AM338_25500 ENOG4106I92 NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) AM338_25510 ENOG4107SJW iron permease, FTR1 AM338_25525 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) AM338_25530 ENOG4107R39 (ABC) transporter AM338_25535 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) AM338_25550 ENOG4105D6F Phosphatase AM338_25575 ENOG4105EKQ RNA-directed DNA polymerase AM338_25645 ENOG41063SR receptor AM338_25670 ENOG4105EKQ RNA-directed DNA polymerase AM338_25700 ENOG4105C87 Aminotransferase class I and II AM338_25705 ENOG4105CHR reductase AM338_25710 ENOG4107ZXU DSBA oxidoreductase AM338_25715 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase AM338_25770 ENOG4108KTG Membrane protein, drug metabolite transporter AM338_25810 ENOG4106CQM replication AM338_25825 ENOG4107AVE This protein is involved in the determination of copy number in gene replication. It binds to the repA promoter thus inhibiting the synthesis of the mRNA for the initiator protein repA (By similarity) AM338_25830 ENOG4105EQR Transposase IS116 IS110 IS902 AM338_25860 ENOG4108YXQ IS66 Orf2 family protein AM338_25880 ENOG4105CSX c4-dicarboxylate anaerobic carrier AM338_25885 ENOG4105DBV ornithine carbamoyltransferase AM338_25890 ENOG4105C5B carbamate kinase AM338_25895 ENOG4105CEU Arginine dihydrolase AM338_25950 ENOG4105E5H Transposase AM338_25955 ENOG4108YXQ IS66 Orf2 family protein AM338_25960 ENOG4108ZQS transposase AM338_25980 ENOG4107CBI conjugal transfer fertility inhibition protein AM338_26095 ENOG4105EKQ RNA-directed DNA polymerase AM338_26110 ENOG4105M0J Toxic component of a toxin-antitoxin (TA) module. A AM338_26230 ENOG4108R0M Aminoglycoside AM338_26240 ENOG4105EKQ RNA-directed DNA polymerase AM338_26270 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) AM338_26315 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) AM338_26350 ENOG4107RHT methyl-accepting chemotaxis sensory transducer with Pas Pac sensor AM338_26405 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) AM338_26410 ENOG4108X73 DNA- binding protein AM338_26420 ENOG4105KF5 hemolysin expression-modulating protein AM338_26550 ENOG41074AV Hok/gef family AM338_26580 ENOG4107QX8 SPFH domain, Band 7 family protein AM338_26680 ENOG4105EJX conjugal transfer ATPase AM338_26705 ENOG4108EHY type IV secretion system AM338_26730 ENOG4107QHF type ii secretion system protein e AM338_26785 ENOG4105KK6 nuclease