locus-tag class description HPM96_00005 ENOG4105K5X acetyltransferase HPM96_00015 ENOG4107QP3 malate synthase g HPM96_00020 ENOG4108I9X Isocitrate lyase HPM96_00025 ENOG4105VS7 Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation (By similarity) HPM96_00030 ENOG41069M3 Transcriptional regulator HPM96_00040 ENOG4105EAM Na Pi-cotransporter HPM96_00050 ENOG4105F9E Shikimate 5-dehydrogenase HPM96_00055 ENOG4105DXH Alcohol dehydrogenase zinc-binding domain protein HPM96_00060 ENOG4105F3R pts system mannose fructose sorbose family iid HPM96_00065 ENOG4105ETZ PTS System HPM96_00070 ENOG4105KPI PTS system sorbose subfamily IIB component HPM96_00075 ENOG4108XCU pts system HPM96_00080 ENOG4105CHR reductase HPM96_00085 ENOG4105DKT Transcriptional regulator HPM96_00090 ENOG4105FE9 pseudouridine synthase HPM96_00095 ENOG4108ZR5 Conserved Protein HPM96_00105 ENOG410756H nucleotidyltransferase HPM96_00120 ENOG410685N tail fiber protein HPM96_00200 ENOG4107SC1 transglycosylase HPM96_00215 ENOG4105CFH Aspartokinase HPM96_00230 ENOG4108MDC (LipO)protein HPM96_00235 ENOG4108Q9C Periplasmic Protein HPM96_00240 ENOG4105E3R (LipO)protein HPM96_00255 ENOG4105EG2 ABC transporter, permease HPM96_00260 ENOG4105D56 permease protein HPM96_00265 ENOG4107FKK extracellular solute-binding protein family 1 HPM96_00270 ENOG4108IJ9 (ABC) transporter HPM96_00280 ENOG4107W52 maltose operon periplasmic protein HPM96_00305 ENOG41080IJ Diacylglycerol kinase HPM96_00315 ENOG4107R73 Mate efflux family protein HPM96_00320 ENOG4105VDW Csbd family HPM96_00325 ENOG4105MYN Zinc uptake regulation protein HPM96_00335 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) HPM96_00340 ENOG4105P4Z Phage shock protein G HPM96_00345 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein HPM96_00350 ENOG4105CDU Replicative dna helicase HPM96_00355 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) HPM96_00360 ENOG4105CGF Aromatic amino acid aminotransferase HPM96_00370 ENOG4105F0S class B acid phosphatase HPM96_00375 ENOG4108YXI Secondary thiamine-phosphate synthase enzyme HPM96_00380 ENOG4105MSB protein, conserved in bacteria HPM96_00385 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) HPM96_00390 ENOG4108UUM single-stranded DNA-binding protein HPM96_00395 ENOG4105PMV Membrane HPM96_00400 ENOG4108M8H domain protein HPM96_00405 ENOG4108W3Q Transcriptional regulator HPM96_00410 ENOG4108Z4X TRANSCRIPTIONal HPM96_00415 ENOG4105C7N Xanthine uracil vitamin C permease HPM96_00420 ENOG4105EEQ Na H antiporter HPM96_00430 ENOG41062QD Membrane HPM96_00435 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) HPM96_00445 ENOG4105JJ8 Cytochrome c nitrite reductase, pentaheme subunit HPM96_00450 ENOG4105D3S 4Fe-4S Ferredoxin, iron-sulfur binding domain protein HPM96_00455 ENOG4105DVI reductase, NrfD HPM96_00460 ENOG4108QKW cytochrome c-type biogenesis protein HPM96_00470 ENOG4108W0S formate-dependent nitrite reductase complex HPM96_00475 ENOG4105CK2 sodium dicarboxylate symporter HPM96_00480 ENOG41082ND Uncharacterized protein yjcO HPM96_00490 ENOG4105ETP RND efflux system, outer membrane lipoprotein HPM96_00495 ENOG4108MI0 Resistance protein HPM96_00500 ENOG4105J12 Multidrug resistance protein mdtN HPM96_00505 ENOG4106833 HPM96_00510 ENOG4105EUZ Beta-lactamase domain protein HPM96_00515 ENOG4107TFG D-allose kinase HPM96_00520 ENOG4105UP7 3-epimerase HPM96_00525 ENOG4105CNN ABC, transporter HPM96_00530 ENOG4105C2J ABC transporter HPM96_00535 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator HPM96_00540 ENOG4105NYY transcriptional regulator, RpiR HPM96_00545 ENOG4108YZG isomerase HPM96_00555 ENOG4107SA6 carbon-phosphorus lyase complex accessory protein HPM96_00560 ENOG410849A acetyltransferase, (GNAT) family HPM96_00570 ENOG4105FD8 phosphonate metabolism protein PhnM HPM96_00575 ENOG4105HRV phosphonate c-p lyase system protein phnl HPM96_00580 ENOG4105ENV phosphonate C-P lyase system protein PhnK HPM96_00585 ENOG4105FT8 Phosphonate metabolism HPM96_00590 ENOG4105EKV Phosphonate metabolism protein HPM96_00595 ENOG4105KZ6 phosphonate C-P lyase system protein PhnH HPM96_00600 ENOG4105KQZ Phosphonate C-P lyase system protein PhnG HPM96_00605 ENOG4107RJJ Transcriptional regulator HPM96_00615 ENOG4105EHI Phosphonate ABC transporter, periplasmic HPM96_00620 ENOG4105D5T phosphonate abc transporter HPM96_00625 ENOG4108SQ4 Glyoxalase Bleomycin resistance protein (Dioxygenase HPM96_00630 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA HPM96_00635 ENOG4108F5E vimentin HPM96_00640 ENOG4108YIV HPM96_00645 ENOG4105CSH Transporter HPM96_00655 ENOG4105ECM Sensor protein basS pmrB HPM96_00660 ENOG4105XJC Two component transcriptional regulator (Winged helix family HPM96_00665 ENOG4105DIJ Phosphoethanolamine transferase HPM96_00670 ENOG4105D5Q Arginine ornithine antiporter HPM96_00675 ENOG4106ZGR Transcriptional regulator HPM96_00680 ENOG4105CXN decarboxylase HPM96_00685 ENOG4108K2B transcriptional regulator HPM96_00690 ENOG4105F8D glycoside hydrolase family 4 HPM96_00695 ENOG4108R5S membrane HPM96_00700 ENOG4107GFK fumarate HPM96_00705 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter HPM96_00710 ENOG4108MRH transcriptional regulatory protein HPM96_00715 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism HPM96_00720 ENOG4105VR1 Pfam:DUF1271 HPM96_00725 ENOG410830R acetyltransferase HPM96_00740 ENOG4105CRK lysyL-tRNA synthetase HPM96_00745 ENOG4105DUX Transporter HPM96_00750 ENOG4105CXN decarboxylase HPM96_00755 ENOG4105D5Q Arginine ornithine antiporter HPM96_00760 ENOG4108M3R transcriptional activator CadC HPM96_00770 ENOG4108SIC Transcriptional regulator HPM96_00785 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter HPM96_00790 ENOG4108IJ0 Aspartate ammonia-lyase HPM96_00795 ENOG4108YH1 overproduction of this protein in Escherichia coli inhibits the F plasmid-mediated exclusion of bacteriophage T7 HPM96_00800 ENOG4105DVH amino acid HPM96_00815 ENOG4108ZVF (LipO)protein HPM96_00820 ENOG4105MTB Uncharacterized protein YjeJ HPM96_00825 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein HPM96_00835 ENOG4107PEH Entericidin EcnA/B family HPM96_00840 ENOG4106BSU Entericidin B HPM96_00845 ENOG4105KPY Small multidrug resistance protein HPM96_00850 ENOG4105QNF Outer membrane lipoprotein HPM96_00870 ENOG4105E33 succinate dehydrogenase HPM96_00875 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) HPM96_00885 ENOG4107SC7 Inner membrane transporter yjeM HPM96_00905 ENOG4106CG8 Inner membrane protein YjeO HPM96_00910 ENOG4105EGS Mechanosensitive ion channel HPM96_00955 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) HPM96_00960 ENOG4105K8N protein family UPF0079, ATPase HPM96_00965 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase HPM96_00985 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) HPM96_00990 ENOG4107QJR hflk protein HPM96_00995 ENOG4105EPW hflc protein HPM96_01015 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) HPM96_01020 ENOG4105C2N RNA methyltransferase TrmH family group 3 HPM96_01025 ENOG4105FUX Conserved Protein HPM96_01030 ENOG4108P9J Phage shock protein A HPM96_01035 ENOG4107VNS Protein of unknown function (DUF2491) HPM96_01040 ENOG4105Z6B inner membrane protein yjfl HPM96_01045 ENOG4108KXT Conserved Protein HPM96_01050 ENOG4106032 Glutathionylspermidine synthase HPM96_01055 ENOG4105CSU acyl-Coa dehydrogenase HPM96_01060 ENOG4105S17 UPF0379 protein yjfN HPM96_01065 ENOG4105WSB biofilm stress and motility protein A HPM96_01070 ENOG4108MXZ Esterase HPM96_01085 ENOG4105CZC PTS system ascorbate-specific transporter subunit IIC HPM96_01115 ENOG4105KIT UPF0379 protein yjfY HPM96_01130 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) HPM96_01140 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit HPM96_01145 ENOG4105CG6 trap dicarboxylate transporter dctm subunit HPM96_01150 ENOG41069H7 transport system small permease component HPM96_01155 ENOG4107S3R L-aspartate oxidase HPM96_01160 ENOG4107R0K CoA transferase having broad substrate specificity for short-chain acyl-CoA thioesters with the activity decreasing when the length of the carboxylic acid chain exceeds four carbons (By similarity) HPM96_01165 ENOG4105E39 Enoyl-CoA hydratase HPM96_01175 ENOG4105CHR reductase HPM96_01185 ENOG4105FHY Opacity-associated protein A HPM96_01190 ENOG4108V1T peptidylprolyl cis-trans isomerase HPM96_01215 ENOG4105DXC membrane HPM96_01220 ENOG4105ECR NmrA family HPM96_01225 ENOG4105KVH Transcriptional regulator HPM96_01230 ENOG4107RNS bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase 3'-nucleotidase periplasmic HPM96_01235 ENOG4108RNI 3'(2')5'-bisphosphate nucleotidase HPM96_01240 ENOG4108UUE Transcriptional regulator HPM96_01245 ENOG41061GZ Protein of unknown function (DUF1107) HPM96_01250 ENOG4105C37 (CBS) domain HPM96_01260 ENOG4105CFU surface antigen HPM96_01265 ENOG4105MA0 exported protein HPM96_01270 ENOG4108ZHD aig2 family HPM96_01275 ENOG41087RY SpoVT_AbrB HPM96_01280 ENOG4105MZG transcriptional modulator of maze toxin, mazf HPM96_01285 ENOG4105F0N pyrophosphate phospho-hydrolase HPM96_01290 ENOG4107R5U Periplasmic binding protein LacI transcriptional regulator HPM96_01295 ENOG4105C2J ABC transporter HPM96_01300 ENOG4107R9N ABC transporter HPM96_01305 ENOG41062B0 ABC transporter, permease HPM96_01315 ENOG4105DFU Cell wall formation (By similarity) HPM96_01325 ENOG4105CMS peptidase U62, modulator of DNA gyrase HPM96_01330 ENOG4108XVM Cytochrome b(562) HPM96_01340 ENOG4105K4U addiction module toxin, RelE StbE family HPM96_01345 ENOG4108RDD Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine (By similarity) HPM96_01350 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase HPM96_01355 ENOG4105CG3 alpha amylase, catalytic region HPM96_01360 ENOG4105C5Y PTS System HPM96_01365 ENOG4105D4X repressor HPM96_01375 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic HPM96_01380 ENOG4105KME endoribonuclease L-psp HPM96_01395 ENOG4107C93 pyrBI operon leader peptide HPM96_01400 ENOG4108UQ8 endoribonuclease L-psp HPM96_01405 ENOG4105F6U Short-chain dehydrogenase reductase Sdr HPM96_01410 ENOG4108XFH Transcriptional regulator HPM96_01415 ENOG4105XEP YhcH YjgK YiaL family protein HPM96_01430 ENOG4105KQT Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome (By similarity) HPM96_01435 ENOG4108MJ3 acetyltransferase HPM96_01440 ENOG4108M3P Membrane HPM96_01445 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) HPM96_01450 ENOG4105MYG DNA polymerase iii, chi subunit HPM96_01460 ENOG4108M8S permease YjgP YjgQ family protein HPM96_01465 ENOG4108K5H permease YjgP YjgQ family protein HPM96_01470 ENOG4105D7A ATP-binding protein HPM96_01475 ENOG4105K2J Transcriptional regulator HPM96_01480 ENOG4105C6Z Gluconate HPM96_01485 ENOG4105CHR reductase HPM96_01490 ENOG4105CPQ Dehydrogenase HPM96_01495 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family HPM96_01500 ENOG4105DQ4 alcohol dehydrogenase HPM96_01515 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) HPM96_01535 ENOG4105CVR type I restriction-modification system HPM96_01550 ENOG4105DZR Type I site-specific deoxyribonuclease HPM96_01570 ENOG4108MX5 Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses (By similarity) HPM96_01575 ENOG41069FU Outer membrane channel protein allowing the entry of N- acetylneuraminic acid (Neu5Ac, the most abundant sialic acid on host cell surfaces) into the bacteria HPM96_01580 ENOG4108W9T type 1 fimbriae regulatory protein HPM96_01585 ENOG4105E71 FimE is one of the 2 regulatory proteins which control the phase variation of type 1 fimbriae in E.coli. These proteins mediate the periodic inversion of a 300bp DNA segment that harbors the promoter for the fimbrial structural gene, fimA. FimE switches fimA off HPM96_01590 ENOG4108RQP Major type 1 subunit fimbrin HPM96_01595 ENOG4108S54 Fimbrial protein HPM96_01600 ENOG4108NAE Fimbrial chaperone protein HPM96_01605 ENOG4105CW0 outer membrane usher protein HPM96_01610 ENOG4108SQA Fimbrial HPM96_01615 ENOG4108T65 Fimbrial HPM96_01620 ENOG410643X FIMH SUBUNIT MANNOSE-sensitive type 1 fimbrial adhesin HPM96_01625 ENOG4107EFN gluconate transport system permease 3 HPM96_01635 ENOG4105DEI Mannitol dehydrogenase HPM96_01640 ENOG4105C6F GntR Family Transcriptional Regulator HPM96_01660 ENOG4107YNJ LysR family Transcriptional regulator HPM96_01665 ENOG4105DYB Isoaspartyl dipeptidase HPM96_01670 ENOG4108P2H Inner membrane protein YjiG HPM96_01675 ENOG41074DU domain protein HPM96_01685 ENOG4105CBP Major Facilitator HPM96_01700 ENOG4105CIZ coA-substrate-specific enzyme activase HPM96_01705 ENOG4105DCU 2-hydroxyglutaryl-CoA dehydratase HPM96_01710 ENOG4106BRA Membrane HPM96_01715 ENOG41083G8 Multidrug resistance protein MdtM HPM96_01730 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HPM96_01735 ENOG4106DIZ Domain of unknown function (DUF1127) HPM96_01755 ENOG4106H3A restriction HPM96_01770 ENOG4105CKI cobalamin synthesis protein HPM96_01775 ENOG4105VCD cytoplasmic protein HPM96_01780 ENOG4105D22 carbon starvation protein HPM96_01800 ENOG4108IA2 Sodium pantothenate symporter HPM96_01810 ENOG4105C8Q Methyl-accepting chemotaxis HPM96_01815 ENOG4108I5G Major Facilitator superfamily HPM96_01820 ENOG410617M Transcriptional regulator HPM96_01825 ENOG4105CPQ Dehydrogenase HPM96_01835 ENOG4105RI1 glycoprotein receptor HPM96_01840 ENOG4106CVF DNA replication protein HPM96_01855 ENOG4105DWK Membrane HPM96_01860 ENOG4108N8T regulatoR HPM96_01865 ENOG4108T94 DNA-binding transcriptional activator BglJ HPM96_01870 ENOG4108819 ferric iron reductase HPM96_01875 ENOG4105YBH Protein of unknown function (DUF1435) HPM96_01900 ENOG4108WPU DNA polymerase III subunit psi HPM96_01905 ENOG4105KEG ribosomal-protein-alanine acetyltransferase HPM96_01910 ENOG4105PAD Hydrolase HPM96_01920 ENOG4108UK2 deaminase HPM96_01930 ENOG41077V0 CPS-53 (KpLE1) prophage HPM96_01935 ENOG4108R7K Metal Dependent Phosphohydrolase HPM96_01940 ENOG4108HJ1 Uncharacterized conserved protein (DUF2303) HPM96_01945 ENOG4105H40 HPM96_01960 ENOG4108S1U HPM96_01965 ENOG4106050 phage regulatory protein, rha family HPM96_01995 ENOG4106CZA Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC (By similarity) HPM96_02005 ENOG4108MXB Protein of unknown function (DUF968) HPM96_02010 ENOG4105HGD Antitermination protein HPM96_02025 ENOG4105VEQ Cold shock protein HPM96_02030 ENOG4105QFS Lysis protein S homolog from lambdoid prophage HPM96_02050 ENOG4108YV9 Protein of unknown function (DUF2514) HPM96_02055 ENOG4105VEQ Cold shock protein HPM96_02065 ENOG4106IAW HPM96_02070 ENOG4106H71 Overexpression increases levels of unsaturated fatty acids and suppresses both the temperature-sensitive fabA6 mutation and cold-sensitive secG null mutation HPM96_02080 ENOG4106YSC HPM96_02090 ENOG4105UZW Tail fiber assembly protein HPM96_02115 ENOG4105IM0 capsid protein HPM96_02190 ENOG4108X9F tail fiber protein HPM96_02215 ENOG4105MN3 Resolvase HPM96_02220 ENOG4105W3V DNA-binding, transcriptional regulator HPM96_02230 ENOG4106FE3 DNA repair HPM96_02240 ENOG4105K3G Periplasmic Protein HPM96_02250 ENOG4108NRW Phospholipase, patatin family HPM96_02255 ENOG4105EYA deoxyribonuclease HPM96_02260 ENOG41076CZ activating enzyme HPM96_02265 ENOG4105G0K glycine radical enzyme YjjI family HPM96_02285 ENOG4105D3A purine nucleoside phosphorylase DeoD-type HPM96_02300 ENOG41062Z9 Membrane HPM96_02305 ENOG4105EAC phosphoserine phosphatase HPM96_02310 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) HPM96_02315 ENOG4107VZS Nicotinamide-nucleotide adenylyltransferase HPM96_02325 ENOG4105C5H ABC transporter HPM96_02330 ENOG4107SC1 transglycosylase HPM96_02350 ENOG4105UEI Transcriptional Regulator AraC Family HPM96_02355 ENOG4108RH0 Crea protein HPM96_02360 ENOG4105E3W Two component transcriptional regulator (Winged helix family HPM96_02365 ENOG4105EB3 Histidine kinase HPM96_02370 ENOG4105CT7 inner membrane cred family protein HPM96_02375 ENOG41065U4 response regulator HPM96_02380 ENOG410759A HPM96_02385 ENOG4106FVC RNA methyltransferase HPM96_02395 ENOG4105CFH Aspartokinase HPM96_02405 ENOG4105D98 threonine synthase HPM96_02410 ENOG41062C6 Protein of unknown function (DUF2502) HPM96_02420 ENOG4105BZG amino acid carrier protein HPM96_02430 ENOG4108RIR Molybdenum cofactor biosynthesis protein HPM96_02435 ENOG4106HK8 GPR1 FUN34 yaaH family protein HPM96_02440 ENOG4108QUJ UPF0174 protein YaaW HPM96_02460 ENOG4105WI6 cell killing protein encoded within cryptic prophage HPM96_02470 ENOG41061MV Arylsulfatase HPM96_02480 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) HPM96_02485 ENOG41063Z6 transcriptional regulator, lysR family HPM96_02505 ENOG410647N response to DNA damage stimulus HPM96_02510 ENOG4105DTN riboflavin biosynthesis protein ribF HPM96_02525 ENOG41090X3 Peptidyl-prolyl cis-trans isomerase HPM96_02545 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain HPM96_02550 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain HPM96_02555 ENOG4108XNW Transcriptional activatory protein CaiF HPM96_02585 ENOG4105C94 Transporter HPM96_02600 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase HPM96_02605 ENOG4105IBM Could be part of an electron transfer system required for anaerobic carnitine reduction. Could be a 3Fe-4S cluster- containing protein HPM96_02610 ENOG4105C54 Major Facilitator superfamily HPM96_02620 ENOG4105CKD glutathione-regulated potassium-efflux system protein HPM96_02625 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) HPM96_02665 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) HPM96_02675 ENOG41066UG Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host (By similarity) HPM96_02680 ENOG4105D3G Pseudouridine synthase HPM96_02690 ENOG4105CQ2 DNA polymerase HPM96_02695 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase HPM96_02710 ENOG41063TF transcriptional regulator (AraC HPM96_02725 ENOG4108KF1 Membrane HPM96_02735 ENOG4106SMU thiamine transporter membrane protein HPM96_02740 ENOG4105DP9 ABC transporter HPM96_02785 ENOG41064T2 transcriptional regulator, lysR family HPM96_02795 ENOG4105C7K acetolactate synthase HPM96_02800 ENOG4108ZP8 Acetolactate synthase small subunit HPM96_02810 ENOG4107B7Y DNA-binding transcriptional regulator FruR HPM96_02825 ENOG41063Y6 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) HPM96_02830 ENOG4105CJN penicillin-binding protein HPM96_02835 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) HPM96_02840 ENOG4108EQQ Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity) HPM96_02850 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) HPM96_02855 ENOG4105CNI cell division protein FtsW HPM96_02870 ENOG4105CPF Cell wall formation (By similarity) HPM96_02875 ENOG4105K7E Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity) HPM96_02880 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) HPM96_02885 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) HPM96_02905 ENOG4105M6F mutator MutT protein HPM96_02920 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) HPM96_02930 ENOG4105D7Q type ii secretion system HPM96_02935 ENOG4107QHF type ii secretion system protein e HPM96_02940 ENOG4108ZUW Major pilin subunit HPM96_02945 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase HPM96_02950 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase HPM96_02955 ENOG4106A72 regulatory protein AmpE HPM96_02960 ENOG4105C85 amino acid HPM96_02965 ENOG41073TP transcriptional regulator HPM96_02970 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) HPM96_02975 ENOG4107QSN dihydrolipoamide acetyltransferase HPM96_02980 ENOG4107QN2 dihydrolipoyl dehydrogenase HPM96_02990 ENOG4108NST exported protein HPM96_02995 ENOG4107QIJ Aconitate hydratase 2 HPM96_03015 ENOG4108ZRK uncharacterized protein yacC HPM96_03020 ENOG4105E3B Multicopper oxidase HPM96_03025 ENOG4105DZG Dehydrogenase HPM96_03030 ENOG4108UGV hypoxanthine phosphoribosyltransferase HPM96_03035 ENOG41077A9 carbonic anhydrase HPM96_03040 ENOG4105DA5 (ABC) transporter HPM96_03045 ENOG4105E3A (ABC) transporter HPM96_03050 ENOG4108YTN IIa component HPM96_03055 ENOG4107BJW polysaccharide deacetylase HPM96_03065 ENOG4108A32 Transposase HPM96_03080 ENOG4105P0Q fimbrial-like protein YadC HPM96_03085 ENOG4105SN2 fimbrial-like adhesin protein HPM96_03090 ENOG4105SYG Fimbrial protein HPM96_03095 ENOG4108XEY fimbrial-like adhesin protein HPM96_03100 ENOG4105CW0 outer membrane usher protein HPM96_03105 ENOG4108VEV chaperone HPM96_03115 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase HPM96_03120 ENOG4105DJ0 Poly(A) Polymerase HPM96_03125 ENOG4106F3G Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity) HPM96_03140 ENOG4107XID 2'-5' rna ligase HPM96_03145 ENOG4105CQ7 ATP-dependent helicase HPM96_03150 ENOG4105BZ4 penicillin-binding protein HPM96_03155 ENOG4105E0K tonB-dependent siderophore receptor HPM96_03160 ENOG4105E0A ABC, transporter HPM96_03165 ENOG4105J76 Periplasmic binding protein HPM96_03170 ENOG4105S6R Iron-hydroxamate transporter permease subunit HPM96_03195 ENOG4105EN6 Membrane HPM96_03200 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) HPM96_03215 ENOG4105C0H protease HPM96_03220 ENOG4108IXP Carbohydrate diacid transcriptional activator CdaR HPM96_03240 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) HPM96_03265 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) HPM96_03270 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) HPM96_03275 ENOG4105KNE Phosphatidate cytidylyltransferase HPM96_03280 ENOG4105DZP Membrane-associated zinc metalloprotease HPM96_03290 ENOG4108RFI Molecular chaperone that interacts specifically with outer membrane proteins, thus maintaining the solubility of early folding intermediates during passage through the periplasm (By similarity) HPM96_03295 ENOG4105D7M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) HPM96_03315 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) HPM96_03320 ENOG4105C0B DNA polymerase III (alpha subunit) HPM96_03330 ENOG4105CXN decarboxylase HPM96_03335 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase HPM96_03340 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) HPM96_03345 ENOG4105M1T rho-binding antiterminator HPM96_03355 ENOG4108VWS Yaeq family HPM96_03360 ENOG4108YZN class I peptide chain release factor HPM96_03365 ENOG4107EII Lipoprotein involved with copper homeostasis and adhesion HPM96_03370 ENOG4108UY0 (LipO)protein HPM96_03380 ENOG4108R96 Methyltransferase, YaeB family HPM96_03385 ENOG4108R8X outer membrane lipoprotein HPM96_03390 ENOG4105D01 (LipO)protein HPM96_03395 ENOG4108UMI ABC transporter, permease HPM96_03400 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) HPM96_03405 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase HPM96_03440 ENOG4105CV8 reductase HPM96_03445 ENOG4105HEI LysR family (Transcriptional regulator HPM96_03455 ENOG4105F2W methyltransferase HPM96_03460 ENOG4105E9H Lytic Murein transglycosylase HPM96_03465 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) HPM96_03470 ENOG4105D1A Methyltransferase HPM96_03480 ENOG4107RZZ dna polymerase iii epsilon subunit HPM96_03490 ENOG4105CZ7 nitrilase cyanide hydratase and apolipoprotein n-acyltransferase HPM96_03495 ENOG4108WN0 inhibitor of vertebrate lysozyme HPM96_03500 ENOG4107QPN acyl-Coa dehydrogenase HPM96_03510 ENOG4105E7A Glutamine amidotransferase HPM96_03515 ENOG4105F7V ErfK ybiS ycfS ynhG family protein HPM96_03530 ENOG4108YS0 lipoprotein YafL HPM96_03535 ENOG4108UK5 Transposase HPM96_03555 ENOG4108HYG acetyltransferase HPM96_03565 ENOG4108S2Y peptide Chain Release factor HPM96_03580 ENOG4105CIN aminoacyl-histidine dipeptidase HPM96_03590 ENOG4105V1F Fermentation respiration switch protein HPM96_03600 ENOG4105FCK Membrane HPM96_03620 ENOG4105DFP Integrase HPM96_03735 ENOG4105R3P Inner membrane protein yagU HPM96_03740 ENOG4105PI0 Ferredoxin HPM96_03750 ENOG4106PYX Receptor HPM96_03795 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HPM96_03800 ENOG4105ENX hydrolase HPM96_03805 ENOG410642W LysR family Transcriptional regulator HPM96_03810 ENOG4105EQ2 LysR family Transcriptional regulator HPM96_03815 ENOG4107SET aldo keto reductase HPM96_03825 ENOG4105TNG K13735 adhesin invasin HPM96_03835 ENOG4105CV8 reductase HPM96_03840 ENOG4108KBJ Inner membrane protein YkgB HPM96_03845 ENOG41066GK UPF0379 protein ykgI HPM96_03850 ENOG4107QN2 dihydrolipoyl dehydrogenase HPM96_03855 ENOG4108K01 transcriptional regulator HPM96_03860 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) HPM96_03865 ENOG4107QR9 Iron-sulfur cluster binding protein HPM96_03870 ENOG4108ZZK Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source (By similarity) HPM96_03895 ENOG4105C94 Transporter HPM96_03900 ENOG4105BZU Histidine kinase HPM96_03905 ENOG4108NUU Transcriptional regulator HPM96_03910 ENOG4105SZ2 membrAne HPM96_03915 ENOG4107SNB ankyrin repeat protein YahD HPM96_03920 ENOG4105N16 Protein of unknown function (DUF2877) HPM96_03925 ENOG4107R1Q Membrane protein FdrA HPM96_03930 ENOG4107REC cytoplasmic protein HPM96_03935 ENOG4105C5B carbamate kinase HPM96_03940 ENOG4105DZC cytosine deaminase HPM96_03945 ENOG4105DQ4 alcohol dehydrogenase HPM96_03960 ENOG4105E82 cytochrome subunit of dehydrogenase HPM96_03965 ENOG4105TDT uncharacterized protein yahO HPM96_03970 ENOG4108JU7 Transcriptional regulator HPM96_03975 ENOG4105CR4 methylisocitrate lyase HPM96_03980 ENOG4105BZN citrate synthase HPM96_03985 ENOG4105DXD 2-methylcitrate dehydratase HPM96_03990 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) HPM96_03995 ENOG4105DQW permease for cytosine purines, uracil, thiamine, allantoin HPM96_04000 ENOG4105DZC cytosine deaminase HPM96_04005 ENOG4105DND Transcriptional regulator HPM96_04010 ENOG4107B2H carbonic anhydrase HPM96_04020 ENOG4105DJ2 Major Facilitator Superfamily HPM96_04025 ENOG4108UW5 maltose o-acetyltransferase HPM96_04030 ENOG4105U0F oligosaccharide H symporter, major facilitator superfamily (MFS) HPM96_04040 ENOG4105ETE Transcriptional regulator (LacI family HPM96_04045 ENOG4108K2P TRANSCRIPTIONal HPM96_04080 ENOG4108SC4 )-transporter HPM96_04085 ENOG4105IUQ nucleoprotein polynucleotide-associated enzyme HPM96_04105 ENOG4105SRB Uncharacterized protein yaiO HPM96_04115 ENOG4108PBI Polysaccharide metabolism HPM96_04120 ENOG4107W19 lmbE family HPM96_04125 ENOG4106FTQ Taurine ABC transporter, periplasmic HPM96_04135 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component HPM96_04140 ENOG4105E2B Taurine dioxygenase HPM96_04145 ENOG4105D52 delta-aminolevulinic acid dehydratase HPM96_04155 ENOG4108PNB DNA-binding transcriptional regulator HPM96_04160 ENOG4107R6D beta-lactam binding protein AmpH HPM96_04165 ENOG4108DQG in Escherichia coli SbmA is involved in uptake of microcin J25 HPM96_04170 ENOG4107QS8 (LipO)protein HPM96_04175 ENOG4105FR5 inner membrane protein YaiY HPM96_04180 ENOG4105UNH Membrane HPM96_04185 ENOG4105CPF Cell wall formation (By similarity) HPM96_04200 ENOG4105G6Z alkaline phosphatase HPM96_04205 ENOG4105VIF phosphate starvation-inducible protein HPM96_04210 ENOG4105BZU Histidine kinase HPM96_04215 ENOG4105II7 pyrroline-5-carboxylate reductase HPM96_04230 ENOG4105SS3 HPM96_04235 ENOG4105HBA AroM protein HPM96_04260 ENOG4105DKQ ROK family HPM96_04265 ENOG4105F27 Major Facilitator HPM96_04270 ENOG4105EYH Exonuclease HPM96_04275 ENOG4107RH8 nuclease SbcCD subunit D HPM96_04280 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HPM96_04285 ENOG4105BZU Histidine kinase HPM96_04290 ENOG4105CWM branched-chain amino acid transport system II carrier protein HPM96_04295 ENOG4105C85 amino acid HPM96_04300 ENOG4107R28 alpha amylase, catalytic region HPM96_04310 ENOG4108ZYK Acyl carrier protein phosphodiesterase HPM96_04325 ENOG4105VIE preprotein translocase, subunit YajC HPM96_04330 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) HPM96_04335 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) HPM96_04340 ENOG4105X54 addiction module antidote protein HPM96_04350 ENOG4105N1F Hnh endonuclease HPM96_04355 ENOG4105DRB nucleoside-specific channel-forming protein HPM96_04370 ENOG4105D7V transposase HPM96_04385 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) HPM96_04390 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) HPM96_04400 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) HPM96_04405 ENOG4108ZAI phosphatidylglycerophosphatase a HPM96_04410 ENOG4105CPC Aldo Keto reductase HPM96_04420 ENOG4105CTB Polyprenyl synthetase HPM96_04435 ENOG4107S0N DJ-1 family HPM96_04440 ENOG4108JZF Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) HPM96_04450 ENOG4107RDB Major Facilitator HPM96_04475 ENOG41090KH cytochrome o ubiquinol oxidase (subunit iv) HPM96_04480 ENOG4105CCU oxidase (Subunit III) HPM96_04485 ENOG4105BZ9 Cytochrome C oxidase, subunit I HPM96_04490 ENOG4105E2S oxidase) subunit II HPM96_04495 ENOG4105EYM Major Facilitator superfamily HPM96_04500 ENOG4105IEY (LipO)protein HPM96_04505 ENOG4105M85 Bola protein HPM96_04525 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) HPM96_04530 ENOG4105K70 DNA-binding protein HPM96_04535 ENOG4105EIN peptidylprolyl cis-trans isomerase HPM96_04540 ENOG41083P1 competence protein ComEA helix-hairpin-helix repeat protein HPM96_04545 ENOG4108TGP Thioesterase superfamily protein HPM96_04555 ENOG4108NFA extracellular solute-binding protein HPM96_04565 ENOG4108XM1 transcriptional regulator AsnC family HPM96_04570 ENOG4105BZ1 (ABC) transporter HPM96_04575 ENOG4105BZ1 (ABC) transporter HPM96_04580 ENOG4108YZA Nitrogen regulatory protein pii HPM96_04585 ENOG4105BZU Histidine kinase HPM96_04590 ENOG4105C29 acyl-CoA thioesterase HPM96_04595 ENOG4108MNP Glycoprotein polysaccharide metabolism HPM96_04600 ENOG41080UX Methyltransferase HPM96_04610 ENOG4105KCV RNA signal recognition particle 4.5S RNA HPM96_04615 ENOG41066DG (EAL) domain protein HPM96_04620 ENOG4105GSJ Inner membrane protein ylaC HPM96_04625 ENOG4108UW5 maltose o-acetyltransferase HPM96_04630 ENOG4105KF5 hemolysin expression-modulating protein HPM96_04635 ENOG4108UKR Biofilm formation regulator YbaJ HPM96_04640 ENOG4105BZS acriflavin resistance protein HPM96_04645 ENOG4105C1P efflux transporter, rnd family, mfp subunit HPM96_04650 ENOG4107XI7 Tetr family transcriptional regulator HPM96_04655 ENOG4105EGS Mechanosensitive ion channel HPM96_04660 ENOG4106428 Protein of unknown function (DUF2496) HPM96_04665 ENOG4108URS primosomal replication protein n'' HPM96_04670 ENOG4105WD1 Membrane HPM96_04680 ENOG4107QMP dna polymerase iii subunits gamma and tau HPM96_04715 ENOG4107RE1 Inosine-guanosine kinase HPM96_04725 ENOG4105CKD glutathione-regulated potassium-efflux system protein HPM96_04730 ENOG4105EU0 Major facilitator Superfamily HPM96_04735 ENOG4105CGH 5'-nucleotidase HPM96_04740 ENOG4108Z66 YbaK ebsC protein HPM96_04745 ENOG4105MBR gumn family HPM96_04750 ENOG41080ET plasmid maintenance system killer protein HPM96_04755 ENOG41081XE plasmid maintenance system antidote protein, xre family HPM96_04760 ENOG4105C59 p-type ATPase HPM96_04765 ENOG4105CSV Glutaminase HPM96_04770 ENOG4107RY6 amino acid HPM96_04800 ENOG4105G5H Membrane HPM96_04805 ENOG4107QX8 SPFH domain, Band 7 family protein HPM96_04810 ENOG41083J0 (ABC) transporter HPM96_04815 ENOG4105C4B ABC transporter, permease HPM96_04820 ENOG4107QR8 Thioredoxin HPM96_04825 ENOG4105E1F short-chain dehydrogenase reductase HPM96_04830 ENOG4108UJV acyl-CoA thioesterase i HPM96_04835 ENOG4108I0Y (ABC) transporter HPM96_04840 ENOG4105CV6 ABC transporter, permease HPM96_04850 ENOG4107653 Transcriptional regulator HPM96_04860 ENOG4108N16 Negative regulator of allantoin and glyoxylate utilization operons. Binds to the gcl promoter and to the allS- allA intergenic region HPM96_04865 ENOG41060W2 glyoxylate carboligase HPM96_04870 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) HPM96_04875 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase HPM96_04880 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease HPM96_04890 ENOG4105DTE Xanthine uracil vitamin C permease HPM96_04895 ENOG4105BZW Glycerate kinase HPM96_04900 ENOG4105S0E allantoin catabolism protein HPM96_04905 ENOG4105CE7 Amidase, hydantoinase carbamoylase family HPM96_04910 ENOG4105DG4 malate L-lactate dehydrogenase HPM96_04915 ENOG4107R1Q Membrane protein FdrA HPM96_04920 ENOG4107REC cytoplasmic protein HPM96_04925 ENOG4105G5A Protein of unknown function (DUF2877) HPM96_04930 ENOG4105C5B carbamate kinase HPM96_04935 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit HPM96_04940 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) HPM96_04950 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) HPM96_04960 ENOG4105S2T inner membrane protein YbcI HPM96_04965 ENOG4105WQ3 Rna-binding protein HPM96_04975 ENOG4108WDE Fimbrial protein HPM96_04980 ENOG4108AF8 Chaperone HPM96_04985 ENOG4105CW0 outer membrane usher protein HPM96_04990 ENOG4108M66 Involved in regulation of length and mediation of adhesion of SfmA fimbriae (but not necessary for the production of fimbriae). Seems to be mannose binding adhesin (By similarity) HPM96_04995 ENOG4108ZI2 Fimbrial protein HPM96_05000 ENOG4108Q9V regulatoR HPM96_05010 ENOG4108KU3 Integrase HPM96_05100 ENOG410814C multidrug resistance protein HPM96_05110 ENOG4107TII Recombinase HPM96_05130 ENOG4108V2F protein ybcN in lambdoid DLP12 prophage regi HPM96_05135 ENOG410757E Protein NinE homolog from lambdoid prophage DLP12 HPM96_05140 ENOG4105RWQ Protein of unknown function (DUF1364) HPM96_05185 ENOG4105QYK bacteriophage lambda Bor protein homolog HPM96_05190 ENOG4106YSC HPM96_05195 ENOG4105FKG DNA packaging protein HPM96_05200 ENOG4105UZW Tail fiber assembly protein HPM96_05205 ENOG4107DE1 head-to-tail joining protein HPM96_05215 ENOG4105F7J membrane-bound serine protease HPM96_05225 ENOG4105IM0 capsid protein HPM96_05325 ENOG4108WF3 methyltransferase HPM96_05340 ENOG4108NC2 Outer membrane protease HPM96_05350 ENOG4105QUW HPM96_05355 ENOG41090FC Bacteriophage N4 receptor, outer membrane subunit HPM96_05360 ENOG410802X bacteriophage n4 adsorption protein b HPM96_05365 ENOG4105GR3 Histidine kinase HPM96_05370 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HPM96_05375 ENOG4105ENJ RND efflux system, outer membrane lipoprotein HPM96_05380 ENOG410624V efflux system protein HPM96_05385 ENOG4105EP1 Efflux transporter rnd family, mfp subunit HPM96_05390 ENOG4108IJF Heavy metal efflux pump, CzcA HPM96_05395 ENOG4105C85 amino acid HPM96_05400 ENOG4105CUY Mechanosensitive ion channel HPM96_05405 ENOG4108RCM Nitroreductase HPM96_05410 ENOG4105MSB protein, conserved in bacteria HPM96_05415 ENOG4105WQ6 Membrane HPM96_05430 ENOG4108TSE Transferase HPM96_05435 ENOG4107RNH Outer membrane receptor FepA HPM96_05440 ENOG4105E93 esterase HPM96_05445 ENOG41085A6 mbth domain-containing protein HPM96_05450 ENOG4105C0W non-ribosomal peptide synthetase HPM96_05455 ENOG4108QY5 Ferric enterobactin transport protein HPM96_05460 ENOG4105E0A ABC, transporter HPM96_05465 ENOG4105TVJ transport system, permease HPM96_05470 ENOG4105DQ5 transport system permease protein HPM96_05480 ENOG4105PEC Iron-enterobactin transporter periplasmic binding protein HPM96_05485 ENOG4105E4F Isochorismate synthase HPM96_05490 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase HPM96_05495 ENOG4105WQI isochorismatase HPM96_05500 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase HPM96_05505 ENOG4108TZA Required for optimal enterobactin synthesis. Acts as a proofreading enzyme that prevents EntB misacylation by hydrolyzing the thioester bound existing between EntB and wrongly charged molecules (By similarity) HPM96_05510 ENOG4105D22 carbon starvation protein HPM96_05515 ENOG4105VCD cytoplasmic protein HPM96_05520 ENOG4107SCQ Iron-containing alcohol dehydrogenase HPM96_05525 ENOG4105CHM Aminotransferase HPM96_05530 ENOG4105GTN ParB Domain Protein Nuclease HPM96_05535 ENOG4105BZV Phosphoadenosine phosphosulfate reductase HPM96_05540 ENOG4105DQS Transcriptional regulator HPM96_05545 ENOG4108KHN disulfide isomerase, thiol-disulfide oxidase HPM96_05550 ENOG4105D3R alkyl hydroperoxide reductase HPM96_05555 ENOG4108JU3 Alkyl hydroperoxide reductase HPM96_05560 ENOG4108U51 Universal stress protein HPM96_05565 ENOG4105NXH GreA GreB family elongation factor HPM96_05570 ENOG4105KTS ribonuclease HPM96_05575 ENOG4107QPK )-transporter HPM96_05590 ENOG4105CHY citrate lyase, alpha HPM96_05595 ENOG4105CI0 Citrate lyase HPM96_05605 ENOG4105DUA (citrate (pro-3S)-lyase ligase HPM96_05610 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism HPM96_05615 ENOG4106YYS transcriptional regulatory protein HPM96_05620 ENOG4105CEE C4-dicarboxylate transporter HPM96_05625 ENOG41079UR PagP is required both for biosynthesis of hepta-acylated lipid A species containing palmitate and for resistance to cationic antimicrobial peptides (CAMPs). It catalyzes the transfer of a palmitate chain (16 0) from the sn-1 position of a glycerophospholipid to the free hydroxyl group of the (R)-3- hydroxymyristate chain at position 2 of lipid A (endotoxin) (By similarity) HPM96_05645 ENOG410607N Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatE shares overlapping functions with TatA (By similarity) HPM96_05655 ENOG41064T2 transcriptional regulator, lysR family HPM96_05670 ENOG4105DZ1 carboxypeptidase HPM96_05675 ENOG4105K6T rare lipoprotein A HPM96_05680 ENOG4105CNI cell division protein FtsW HPM96_05685 ENOG4105CJN penicillin-binding protein HPM96_05695 ENOG4105KEM Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) HPM96_05700 ENOG4108TGR phosphatase HPM96_05710 ENOG4105DJF DNA polymerase III, delta' subunit HPM96_05715 ENOG4108U2H Rare lipoprotein B HPM96_05725 ENOG4107PAI alpha helical protein HPM96_05730 ENOG4105EUU Sel1 domain protein repeat-containing protein HPM96_05735 ENOG41069CF Protein of unknown function (DUF1266) HPM96_05740 ENOG4105QFC Hsc56 co-chaperone of HscC HPM96_05745 ENOG4107JFD Sel1 repeat HPM96_05750 ENOG41069CF Protein of unknown function (DUF1266) HPM96_05755 ENOG4105QFC Hsc56 co-chaperone of HscC HPM96_05760 ENOG4105F7F Chaperone HPM96_05770 ENOG4105CDA abc transporter atp-binding protein HPM96_05775 ENOG4105DRP amino acid AbC transporter HPM96_05780 ENOG4105EAD ABC transporter HPM96_05785 ENOG4107RP9 extracellular solute-binding protein, family 3 HPM96_05790 ENOG4107U91 Rhomboid family HPM96_05795 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) HPM96_05800 ENOG4108JU5 Magnesium and cobalt efflux protein HPM96_05810 ENOG4105C9A Phoh family HPM96_05820 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family HPM96_05865 ENOG4105CAQ asparagine synthetase HPM96_05870 ENOG4105D4U had-superfamily hydrolase, subfamily iia HPM96_05875 ENOG4105E2R ROK family HPM96_05880 ENOG4105CE4 GlcNAc 6-P deacetylase HPM96_05890 ENOG4105CI1 PTS System HPM96_05905 ENOG4105GX6 (LipO)protein HPM96_05910 ENOG41090R7 Ferric uptake HPM96_05920 ENOG4105MHQ Low-potential electron donor to a number of redox enzymes (By similarity) HPM96_05925 ENOG4105NNH LexA regulated protein HPM96_05930 ENOG4105EV9 Alpha Beta Hydrolase HPM96_05935 ENOG4107CDU Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated (By similarity) HPM96_05940 ENOG4107QIX Phosphoglucomutase (EC 5.4.2.2 HPM96_05945 ENOG4105D5Q Arginine ornithine antiporter HPM96_05950 ENOG4105CXN decarboxylase HPM96_05960 ENOG4105EEX Two component transcriptional regulator (Winged helix family HPM96_05965 ENOG4105C08 Histidine kinase HPM96_05990 ENOG4105XIQ Protein of unknown function (DUF2517) HPM96_05995 ENOG4107SEY Conserved Protein HPM96_06000 ENOG4105CVP deoxyribo-dipyrimidine photolyase HPM96_06005 ENOG4105DUX Transporter HPM96_06010 ENOG4107QNR UPF0135 protein HPM96_06015 ENOG4105P4J Allophanate hydrolase, subunit 1 HPM96_06020 ENOG4107R7A Allophanate hydrolase subunit 2 HPM96_06030 ENOG4108S0J Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized pyrimidines, such as thymine glycol, 5,6-dihydrouracil and 5,6-dihydrothymine. Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'- phosphates (By similarity) HPM96_06035 ENOG4108KK1 membrane protein AbrB duplication HPM96_06040 ENOG41073TP transcriptional regulator HPM96_06045 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) HPM96_06050 ENOG4105CPQ Dehydrogenase HPM96_06055 ENOG4105CHR reductase HPM96_06065 ENOG4105CTX dehydratase HPM96_06070 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit HPM96_06080 ENOG4105CG6 trap dicarboxylate transporter dctm subunit HPM96_06085 ENOG4105BZN citrate synthase HPM96_06095 ENOG4108UTY succinate dehydrogenase, cytochrome b556 subunit HPM96_06100 ENOG4105N1I succinate dehydrogenase, hydrophobic membrane anchor protein HPM96_06105 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) HPM96_06110 ENOG4105E33 succinate dehydrogenase HPM96_06115 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 HPM96_06120 ENOG4105C7S Dehydrogenase HPM96_06130 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha HPM96_06140 ENOG4105CGP Urocanate hydratase HPM96_06145 ENOG4105ETS cytosine purines uracil thiamine allantoin HPM96_06150 ENOG41090B9 response to stress HPM96_06155 ENOG4105CI2 imidazolone-5-propionate hydrolase HPM96_06160 ENOG41088SP formiminoglutamate hydrolase HPM96_06165 ENOG4105C84 Histidine ammonia-lyase HPM96_06170 ENOG4105ETT transcriptional Regulator, LysR family HPM96_06175 ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase HPM96_06180 ENOG4107GFK fumarate HPM96_06205 ENOG4105DJI Methylaspartate mutase, E subunit HPM96_06215 ENOG4107WFU Glutamate mutase subunit sigma HPM96_06230 ENOG4105C4M (Ubiquinol oxidase) subunit I HPM96_06235 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii HPM96_06245 ENOG4105KJB cyd operon protein YbgE HPM96_06250 ENOG4107YD3 Thioesterase HPM96_06255 ENOG4105E02 MotA TolQ exbB proton channel HPM96_06265 ENOG4108Z82 Cell envelope integrity inner membrane protein TolA HPM96_06275 ENOG4105KCK Peptidoglycan-associated lipoprotein HPM96_06280 ENOG4105UFD tol-pal system protein YbgF HPM96_06325 ENOG4106Z1T Nicotinamide Mononucleotide Transporter HPM96_06330 ENOG4105PGM cation diffusion facilitator family transporter HPM96_06335 ENOG4105JND homeobox protein HPM96_06340 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) HPM96_06350 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) HPM96_06360 ENOG4105F0Z galactose-1-phosphate uridylyltransferase HPM96_06365 ENOG4105CMR udp-glucose 4-epimerase HPM96_06370 ENOG4105DKW ABC transporter HPM96_06375 ENOG4105F4R Transcriptional regulator mode HPM96_06385 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein HPM96_06390 ENOG4105E0C molybdate abc transporter HPM96_06400 ENOG4108K4B hydrolase HPM96_06410 ENOG4105F04 LysR family Transcriptional regulator HPM96_06415 ENOG4105C7F AcnD-accessory protein PrpF HPM96_06420 ENOG4107QPK )-transporter HPM96_06425 ENOG4107QM5 aconitate hydratase HPM96_06430 ENOG4105NBR Pectinesterase HPM96_06435 ENOG4108V1U phospholipid-binding protein HPM96_06440 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) HPM96_06455 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) HPM96_06460 ENOG4105E78 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) HPM96_06470 ENOG4105CHW UPF0052 protein HPM96_06480 ENOG4108RIR Molybdenum cofactor biosynthesis protein HPM96_06490 ENOG4105M00 molybdopterin converting factor, subunit 1 HPM96_06495 ENOG4108ZAF Molybdopterin HPM96_06500 ENOG4105HFZ Membrane HPM96_06505 ENOG410733J conserved inner membrane protein HPM96_06510 ENOG4107UXM Membrane HPM96_06515 ENOG4105DZQ phospholipase D Transphosphatidylase HPM96_06520 ENOG4105X23 Endonuclease Exonuclease phosphatase HPM96_06525 ENOG4105I9U inner membrane protein ybhQ HPM96_06530 ENOG4107QWP ABC-2 type transporter HPM96_06535 ENOG4107QWP ABC-2 type transporter HPM96_06540 ENOG4105CJ1 ABC, transporter HPM96_06550 ENOG4107MVR Transcriptional regulator HPM96_06555 ENOG4105C1J atp-dependent rna helicase HPM96_06570 ENOG4105DVT helicase HPM96_06575 ENOG4108MTB glycosyl transferase family HPM96_06580 ENOG4105DG4 malate L-lactate dehydrogenase HPM96_06585 ENOG4105VR4 UPF0379 protein ybiJ HPM96_06590 ENOG4105KSC Transcriptional regulator, TraR DksA family HPM96_06600 ENOG4108IU3 tonb-dependent siderophore receptor HPM96_06605 ENOG4105ZY9 UPF0379 protein ybiM HPM96_06615 ENOG4105D8X mechanosensitive ion channel HPM96_06620 ENOG4105CDA abc transporter atp-binding protein HPM96_06625 ENOG4105E5Q amino acid AbC transporter HPM96_06630 ENOG4107R0W ABC transporter HPM96_06640 ENOG4107AQZ Membrane HPM96_06650 ENOG4108T1M outer membrane protein x HPM96_06655 ENOG4108I6E Sulfatase HPM96_06665 ENOG4105KST dependent repressor HPM96_06670 ENOG4105F4P )-transporter HPM96_06675 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein HPM96_06680 ENOG4105C5H ABC transporter HPM96_06690 ENOG41072TH Protein of unknown function (DUF1479) HPM96_06695 ENOG4108HCJ Hydrolase HPM96_06705 ENOG4105F1A Pyruvate formate-lyase HPM96_06710 ENOG4107T9Z Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) HPM96_06715 ENOG4105D06 uba thif-type nad fad binding protein HPM96_06720 ENOG4105CVM Molybdenum cofactor synthesis domain protein HPM96_06725 ENOG4105D44 asparaginase HPM96_06730 ENOG4108JQ6 ABC transporter HPM96_06735 ENOG4105DEF Extracellular solute-binding protein, family 5 HPM96_06750 ENOG4105BZU Histidine kinase HPM96_06755 ENOG41064RH membrane protein YliF HPM96_06775 ENOG4105UFT Represses biofilm formation in M9C glu and LB glu media but not in M9C and LB media. Seems to act as a global regulator of several genes involved in catabolite repression and stress response and regulation of the uptake and export of signaling pathways. Could be involved the regulation of indole as well as uptake and export of AI-2 through a cAMP-dependent pathway HPM96_06780 ENOG4105D8V Glucose sorbosone dehydrogenase HPM96_06785 ENOG4108TGY Glutathione S-transferase HPM96_06790 ENOG4105DZ1 carboxypeptidase HPM96_06795 ENOG4107FB0 transcriptional regulator DeoR family HPM96_06800 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase HPM96_06805 ENOG4107QF7 multi-drug HPM96_06815 ENOG4108HCJ Hydrolase HPM96_06820 ENOG4106UW1 Major Facilitator superfamily HPM96_06825 ENOG4108RFG Tetr family transcriptional regulator HPM96_06835 ENOG4105GWF inner membrane protein YbjM HPM96_06840 ENOG41090BQ Glutaredoxin HPM96_06845 ENOG4105X20 member of the soxRS regulon which mediates in part the increased levels of superoxide in response to oxidative stress HPM96_06850 ENOG4108DBC nitroreductase HPM96_06860 ENOG4108RMJ sensory transduction regulator HPM96_06865 ENOG4107RUE extracellular solute-binding protein family 1 HPM96_06870 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HPM96_06875 ENOG4105F38 ABC transporter, permease HPM96_06880 ENOG4105D38 putrescine abc transporter HPM96_06885 ENOG4105RBQ inner membrane protein ybjO HPM96_06895 ENOG4106TNF Periplasmic binding protein HPM96_06900 ENOG4105DMR ABC, transporter HPM96_06905 ENOG4105GBT ABC transporter HPM96_06910 ENOG4106PMH Extracellular solute-binding protein family 3 HPM96_06915 ENOG4105E5Z arginine transporter ATP-binding subunit HPM96_06920 ENOG41064MM (LipO)protein HPM96_06935 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase HPM96_06940 ENOG4107VBM 3-beta hydroxysteroid dehydrogenase isomerase HPM96_06945 ENOG4105CGD Nad-dependent epimerase dehydratase HPM96_06950 ENOG4105C5W Aldolase HPM96_06955 ENOG4105C7K acetolactate synthase HPM96_06960 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) HPM96_06965 ENOG4105EJ7 Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity) HPM96_06970 ENOG4105DWU Membrane HPM96_06975 ENOG4105EQR Transposase IS116 IS110 IS902 HPM96_06985 ENOG4105ETP RND efflux system, outer membrane lipoprotein HPM96_06990 ENOG4105H9W Short-chain dehydrogenase reductase Sdr HPM96_06995 ENOG4105KHU inner membrane protein YohD HPM96_07000 ENOG41069YE inner membrane protein yohC HPM96_07005 ENOG41061WM D-Alanyl-D-Alanine HPM96_07010 ENOG4105CXG d-lactate dehydrogenase HPM96_07015 ENOG4107QK4 glycoside hydrolase, family 3 domain protein HPM96_07020 ENOG4107SI7 Substrate-binding region of abc-type glycine betaine transport system HPM96_07025 ENOG4107T5X Binding-protein-dependent transport systems, inner membrane component HPM96_07030 ENOG4108IJ8 ABC transporter HPM96_07035 ENOG4105WJV Binding-protein-dependent transport systems, inner membrane component HPM96_07045 ENOG4108XDN Transcriptional regulator HPM96_07050 ENOG4108HRK Histidine kinase HPM96_07055 ENOG4108NEV two component transcriptional regulator, LytTR family HPM96_07060 ENOG4108W15 Protein of unknown function (DUF1456) HPM96_07065 ENOG4108YCW (LipO)protein HPM96_07070 ENOG410903U zinc ion binding HPM96_07075 ENOG4105DEG Vwa containing coxe family protein HPM96_07080 ENOG4105RD5 HPM96_07085 ENOG4105KKX ATPase associated with various cellular activities aaa_5 HPM96_07095 ENOG4108KDT Molybdate metabolism regulator HPM96_07100 ENOG4108KDT Molybdate metabolism regulator HPM96_07105 ENOG4108KDT Molybdate metabolism regulator HPM96_07115 ENOG4105D1F ATP-binding protein HPM96_07120 ENOG41067AK Protein of unknown function (DUF2574) HPM96_07125 ENOG41063W2 Fimbrial protein HPM96_07130 ENOG4108MQF Chaperone HPM96_07135 ENOG4105CW0 outer membrane usher protein HPM96_07140 ENOG410662B Type-1 fimbrial protein HPM96_07145 ENOG4108Z1S Influences nickel and cobalt homeostasis. May act by modulating RcnA-mediated export of these ions to avoid excess efflux. Not involved in nickel import and does not bind nickel or cobalt ions directly HPM96_07150 ENOG41061MD high-affinity nickel-transporter HPM96_07210 ENOG4105DWF phosphomethylpyrimidine kinase HPM96_07215 ENOG4108UQ1 hydrolase, family 25 HPM96_07220 ENOG4105FDP GntR family transcriptional regulator HPM96_07225 ENOG4108TFM Kinase, PfkB family HPM96_07230 ENOG4108KD5 ADP-ribosylation crystallin J1 HPM96_07235 ENOG4105EAA nucleoside HPM96_07240 ENOG4105EIE fructose-bisphosphate aldolase HPM96_07245 ENOG4105D2N Aldolase HPM96_07255 ENOG41082GB PTS system galactitol-specific transporter subunit IIA HPM96_07260 ENOG41090UW PTS System HPM96_07265 ENOG4105DT3 PTS system, galactitol-specific IIc component HPM96_07270 ENOG4107WTH Galactitol-1-phosphate dehydrogenase HPM96_07285 ENOG41076Z6 Uncharacterized protein yegR HPM96_07290 ENOG4105CFP Peptidase U32 HPM96_07300 ENOG4105X54 addiction module antidote protein HPM96_07305 ENOG4105KWI UPF0339 protein HPM96_07310 ENOG4105E3W Two component transcriptional regulator (Winged helix family HPM96_07315 ENOG4105EB3 Histidine kinase HPM96_07365 ENOG4108M24 von Willebrand factor, type A HPM96_07370 ENOG4105UM3 Inherit from NOG: serine threonine phosphoprotein phosphatase HPM96_07375 ENOG4106E1W protein with protein kinase and helix-hairpin-helix DNA-binding HPM96_07380 ENOG4105R8A Heat shock protein HPM96_07385 ENOG4105D03 DNA-3-methyladenine glycosylase II HPM96_07390 ENOG4105BZU Histidine kinase HPM96_07395 ENOG4105DBI uridine monophosphokinase HPM96_07405 ENOG4108GAE asmA family HPM96_07420 ENOG4105EE5 Membrane protein terC HPM96_07430 ENOG4105DAY polysaccharide export protein HPM96_07435 ENOG4105KJF protein tyrosine phosphatase HPM96_07440 ENOG4105D75 Capsular exopolysaccharide family HPM96_07445 ENOG41090RK glycosyl transferase HPM96_07450 ENOG41068PY Colanic acid biosynthesis acetyltransferase wcaB HPM96_07455 ENOG4107RXY Glycosyl transferase HPM96_07460 ENOG4108NYJ Colanic acid HPM96_07465 ENOG4105ECJ Glycosyl Transferase HPM96_07470 ENOG4108Z90 colanic acid biosynthesis acetyltransferase wcaF HPM96_07475 ENOG4105C0K Gdp-mannose 4,6-dehydratase HPM96_07480 ENOG4105C30 Nad-dependent epimerase dehydratase HPM96_07485 ENOG4105FGF GDP-mannose mannosyl hydrolase HPM96_07490 ENOG4106CD9 glycosyl transferase group 1 HPM96_07495 ENOG4105CJT Mannose-1-phosphate guanylyltransferase HPM96_07500 ENOG4107QKV phosphomannomutase HPM96_07505 ENOG4105D3Q Sugar transferase HPM96_07510 ENOG4105PSV Polysaccharide Biosynthesis Protein HPM96_07515 ENOG4105C74 pyruvyl transferase HPM96_07520 ENOG4107T8Q Glycosyl transferase (Group 1 HPM96_07525 ENOG4105G1A colanic acid biosynthesis protein HPM96_07530 ENOG4105DMT epimerase dehydratase HPM96_07535 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase HPM96_07540 ENOG4105ER6 polysaccharide biosynthesis protein HPM96_07545 ENOG4105ECJ Glycosyl Transferase HPM96_07555 ENOG4107XU6 Glycosyl transferase (Group 1 HPM96_07560 ENOG4105CMR udp-glucose 4-epimerase HPM96_07570 ENOG4105C0K Gdp-mannose 4,6-dehydratase HPM96_07575 ENOG4105C30 Nad-dependent epimerase dehydratase HPM96_07580 ENOG4105FGF GDP-mannose mannosyl hydrolase HPM96_07595 ENOG4107QKV phosphomannomutase HPM96_07600 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) HPM96_07605 ENOG4105C6Y Udp-glucose 6-dehydrogenase HPM96_07610 ENOG4108KPN Confers a modal distribution of chain length on the O- antigen component of lipopolysaccharide (LPS). Gives rise to a reduced number of short chain molecules and increases in numbers of longer molecules, with a modal value of 13 (in strain O111 M92) and of 17 (in strain K12) HPM96_07630 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) HPM96_07635 ENOG4105ECC imidazole-glycerol-phosphate dehydratase HPM96_07645 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) HPM96_07660 ENOG4107SRH Nad-dependent epimerase dehydratase HPM96_07665 ENOG4105EQ1 Transcriptional regulator HPM96_07675 ENOG4105CUB amino acid HPM96_07680 ENOG4105CUC YeeE YedE family protein HPM96_07690 ENOG4105CJB Exodeoxyribonuclease I HPM96_07695 ENOG4105DZ1 carboxypeptidase HPM96_07705 ENOG4105DR8 Membrane HPM96_07740 ENOG4105MAW Antitoxin component of a toxin-antitoxin (TA) module. Labile antitoxin that counteracts the effect of the CbtA (YeeV) toxin. It does not bind to the cognate toxin but instead binds to MreB and FtsZ (the toxin targets), enhancing their polymerization by forming higher-order bundles HPM96_07750 ENOG4108YGG dna repair protein HPM96_07755 ENOG4105MFG Antirestriction protein HPM96_07760 ENOG4106H6R UPF0380 protein HPM96_07780 ENOG4108YIV HPM96_07785 ENOG4108F5E vimentin HPM96_07855 ENOG41080QX K07048 phosphotriesterase-related protein HPM96_07870 ENOG4108RVA ribokinase HPM96_07890 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter HPM96_07900 ENOG4107YNJ LysR family Transcriptional regulator HPM96_07910 ENOG4105DJB Major Facilitator Superfamily HPM96_07920 ENOG4108RTU Aldolase HPM96_07925 ENOG4105EI3 2-dehydro-3-deoxygalactonokinase EC 2.7.1.58 HPM96_07930 ENOG4105EMF GntR family transcriptional regulator HPM96_07960 ENOG4105ETE Transcriptional regulator (LacI family HPM96_07970 ENOG4105KT7 mgtC SapB transporter HPM96_07990 ENOG4105D44 asparaginase HPM96_08010 ENOG4105CEE C4-dicarboxylate transporter HPM96_08015 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) HPM96_08025 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter HPM96_08030 ENOG4105HDK L-asparaginase HPM96_08035 ENOG4108MRH transcriptional regulatory protein HPM96_08040 ENOG4105JXH GntR family transcriptional regulator HPM96_08045 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter HPM96_08050 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter HPM96_08055 ENOG4105CH7 arginosuccinase HPM96_08070 ENOG4105BZV Phosphoadenosine phosphosulfate reductase HPM96_08075 ENOG4105GTN ParB Domain Protein Nuclease HPM96_08085 ENOG4108YZT Adenosylcobinamide kinase HPM96_08100 ENOG4108PXI ErfK YbiS YcfS YnhG HPM96_08110 ENOG4106P55 Transcriptional regulator HPM96_08115 ENOG4107R11 Transcriptional regulator HPM96_08125 ENOG4105UQX Mate efflux family protein HPM96_08135 ENOG4105CDY transcriptional regulatory protein HPM96_08140 ENOG4105FYV Amp nucleosidase HPM96_08145 ENOG4105CSH Transporter HPM96_08155 ENOG4105TNG K13735 adhesin invasin HPM96_08160 ENOG4105TNG K13735 adhesin invasin HPM96_08165 ENOG4107ZSV Receptor HPM96_08170 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase HPM96_08190 ENOG4105C0W non-ribosomal peptide synthetase HPM96_08205 ENOG4105BZ1 (ABC) transporter HPM96_08210 ENOG4105EYM Major Facilitator superfamily HPM96_08230 ENOG4105EXZ Involved in the regulation of ptsG expression by binding and inactivating Mlc (By similarity) HPM96_08240 ENOG4108VKM cytochrome b561 HPM96_08245 ENOG4108MEK Metal-binding protein YodA HPM96_08260 ENOG4105VT2 5-hydroxyisourate hydrolase HPM96_08265 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HPM96_08270 ENOG4107ZY3 Histidine kinase HPM96_08275 ENOG4105TMR Functions as a holding molecular chaperone (holdase) which stabilizes unfolding intermediates and rapidly releases them in an active form once stress has abated. Plays an important role in protecting cells from severe heat shock and starvation, as well as in acid resistance of stationary-phase cells. It catalyzes the conversion of methylglyoxal (MG) to D-lactate in a single glutathione (GSH)-independent step (By similarity) HPM96_08280 ENOG4105ZIT Porin Gram-negative type HPM96_08285 ENOG4105Y0K Inner membrane protein YedR HPM96_08290 ENOG4105EST Metal Dependent Phosphohydrolase HPM96_08295 ENOG4105DVF Cytosine-specific methyltransferase HPM96_08300 ENOG41090BB DNA mismatch endonuclease (vsr) HPM96_08305 ENOG4105FDR Membrane HPM96_08310 ENOG4105CKW Inner membrane protein yedI HPM96_08315 ENOG4105VNZ cytoplasmic protein HPM96_08330 ENOG4105YX3 cellular response to acidity HPM96_08340 ENOG4107TKS colanic acid capsular biosynthesis activation protein A HPM96_08345 ENOG4105D19 Role in flagellar biosynthesis (By similarity) HPM96_08355 ENOG4105CN7 Flagellar biosynthetic protein FliP HPM96_08360 ENOG4105K0P flagellar biosynthesis protein HPM96_08365 ENOG4105DD5 Flagellar motor switch protein HPM96_08370 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) HPM96_08375 ENOG4107ZI8 flagellar basal body-associated protein flil HPM96_08380 ENOG4105WF4 Flagellar hook-length control protein HPM96_08385 ENOG4105GSA Flagellar export protein flij HPM96_08390 ENOG4108JIR Flagellum-specific ATP synthase HPM96_08395 ENOG41090PJ Flagellar assembly protein HPM96_08400 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) HPM96_08405 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) HPM96_08410 ENOG4105VQ0 flagellar hook-basal body complex protein fliE HPM96_08415 ENOG4108RAV Conserved protein HPM96_08425 ENOG41066VF YeeE YedE family protein HPM96_08430 ENOG4108W9D (LipO)protein HPM96_08435 ENOG4105E5K Alpha-amylase HPM96_08440 ENOG4105YXP it directly binds FlhC, thus inhibiting the binding of the FlhC FlhD complex to class 2 promoters, resulting in decreased expression of class 2 flagellar operons. As a chaperone, effects FliD transition to the membrane by preventing its premature polymerization, and by directing it to the export apparatus (By similarity) HPM96_08445 ENOG4105MQ3 flagellar protein FliS HPM96_08450 ENOG4105DTS flagellar hook-associated HPM96_08455 ENOG4105I03 Flagellin HPM96_08460 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HPM96_08465 ENOG4108M9K flagella biosynthesis protein FliZ HPM96_08470 ENOG4105EAB amino acid AbC transporter HPM96_08475 ENOG4105K6H D-cysteine desulfhydrase HPM96_08480 ENOG4105E5Q amino acid AbC transporter HPM96_08485 ENOG4105CDA abc transporter atp-binding protein HPM96_08490 ENOG4105VJY transcriptional regulator HPM96_08495 ENOG4105XVG cytoplasmic protein HPM96_08505 ENOG4105WH1 Two component transcriptional regulator luxr family HPM96_08535 ENOG4106RHG Yeca family HPM96_08540 ENOG4105E0U tyrosine-specific transport protein HPM96_08545 ENOG4105VVZ metal-binding protein HPM96_08550 ENOG41090A1 ferritin HPM96_08555 ENOG4105P23 (LipO)protein HPM96_08565 ENOG4105N4N Protein of unknown function (DUF2766) HPM96_08570 ENOG4108UEC Ferritin-like protein HPM96_08575 ENOG4105DMK Periplasmic binding protein LacI transcriptional regulator HPM96_08580 ENOG4105C2J ABC transporter HPM96_08585 ENOG4105CNN ABC, transporter HPM96_08590 ENOG4108K4C ec 3.1.3.12 HPM96_08600 ENOG4108VA4 Universal stress protein HPM96_08610 ENOG4106CIA Functions in complex with FlhD as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region HPM96_08615 ENOG4107RD7 Flagellar Motor Protein, MotA HPM96_08620 ENOG4105ER2 Ompa motb domain protein HPM96_08625 ENOG4105CBS Chea signal transduction histidine kinase HPM96_08630 ENOG4108V3W Chemotaxis protein, CheW HPM96_08635 ENOG4105C8Q Methyl-accepting chemotaxis HPM96_08640 ENOG4105C8Q Methyl-accepting chemotaxis HPM96_08645 ENOG4105BZU Histidine kinase HPM96_08655 ENOG4108VYJ response regulator receiver protein HPM96_08660 ENOG4108KCC Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P) (By similarity) HPM96_08665 ENOG4105D00 flagellar biosynthetic protein flhB HPM96_08670 ENOG4105D7B Flagellar biosynthesis protein flha HPM96_08675 ENOG4105W13 flagellar protein HPM96_08685 ENOG4106ZCM YecM protein HPM96_08695 ENOG4105CUW cytochrome C-TYPE protein HPM96_08700 ENOG4107QY8 reductase HPM96_08715 ENOG4105WJG Glutathione HPM96_08720 ENOG41081XQ Conserved Protein HPM96_08725 ENOG4105D3W isochorismatase HPM96_08735 ENOG4108TIT dATP pyrophosphohydrolase HPM96_08740 ENOG4105CDY transcriptional regulatory protein HPM96_08750 ENOG4107S01 Repressor protein MetJ HPM96_08775 ENOG4105FAV ABC, transporter HPM96_08785 ENOG4105NXV High-affinity zinc uptake system protein HPM96_08790 ENOG4105DR5 peptidase HPM96_08795 ENOG4105NWR lipid A biosynthesis (Kdo)2-(Lauroyl)-lipid IVA acyltransferase HPM96_08800 ENOG4105CA9 Pyruvate kinase HPM96_08805 ENOG4106KNT transcriptional regulator HPM96_08810 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase HPM96_08815 ENOG4105C01 Dihydroxy-acid dehydratase HPM96_08820 ENOG4108UHU Aldolase HPM96_08830 ENOG4105X2V dna damage-inducible protein HPM96_08840 ENOG4108Q2J Inner membrane protein YebE HPM96_08845 ENOG4105CUG Oligopeptidase b HPM96_08850 ENOG4105UMD exodeoxyribonuclease X HPM96_08855 ENOG4108YGA nitrilase cyanide hydratase and apolipoprotein n-acyltransferase HPM96_08860 ENOG4105MPK DNA polymerase III subunit theta HPM96_08865 ENOG4105FXM Copper resistance protein HPM96_08870 ENOG4108PNC copper resistance HPM96_08875 ENOG4105NKT exported protein HPM96_08880 ENOG4108R1E Serine threonine protein phosphatase 1 HPM96_08885 ENOG4105UVW uncharacterized protein yebW HPM96_08890 ENOG4105WT8 Protein of unknown function (DUF1480) HPM96_08900 ENOG4105DY2 Paraquat-inducible protein b HPM96_08905 ENOG4105H2K paraquat-inducible protein a HPM96_08910 ENOG4108ZGC gaf domain protein HPM96_08920 ENOG4105CN1 protease HPM96_08930 ENOG4105C0R drug resistance transporter emrb qaca subfamily HPM96_08935 ENOG4105J4Q Transcriptional regulator HPM96_08940 ENOG4105TIK HPM96_08950 ENOG4105Q3Y exported protein HPM96_08965 ENOG4105DHI Methyltransferase HPM96_08980 ENOG4105F3R pts system mannose fructose sorbose family iid HPM96_08985 ENOG4105ETZ PTS System HPM96_08990 ENOG4105DAS pts system HPM96_08995 ENOG4105EE5 Membrane protein terC HPM96_09000 ENOG4107XTP (EAL) domain protein HPM96_09005 ENOG4105EJQ L-serine dehydratase HPM96_09010 ENOG4105P8F nudix hydrolase HPM96_09015 ENOG4105CRQ synthase (Component I) HPM96_09025 ENOG4105V2F Uncharacterized protein yoac HPM96_09030 ENOG4105M4H endoribonuclease L-psp HPM96_09035 ENOG4105DVT helicase HPM96_09040 ENOG41072GX Peptidase M22 Glycoprotease HPM96_09045 ENOG4105Y4Z Outer Membrane Lipoprotein HPM96_09050 ENOG4105CEY Amp-dependent synthetase and ligase HPM96_09055 ENOG4105ZIE Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity) HPM96_09060 ENOG4105E3J oxidoreductase HPM96_09065 ENOG4105DVW rieske (2Fe-2S) HPM96_09070 ENOG4105C94 Transporter HPM96_09075 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) HPM96_09080 ENOG4105EJC lysr family transcriptional regulator HPM96_09090 ENOG4108YS1 cytoplasmic protein HPM96_09095 ENOG4105YP6 Domain of unknown function (DUF1869) HPM96_09100 ENOG4105Y3U Transglycosylase-associated protein HPM96_09110 ENOG4106G4W HPM96_09115 ENOG410620I Diguanylate cyclase HPM96_09120 ENOG4105UCG Domain of unknown function (DUF333) HPM96_09125 ENOG4105K78 MarR family Transcriptional regulator HPM96_09130 ENOG4105DJ2 Major Facilitator Superfamily HPM96_09135 ENOG4105R1U AraC Family Transcriptional Regulator HPM96_09150 ENOG4108KXH Ybak prolyl-tRNA synthetase associated HPM96_09155 ENOG4108KHP Diguanylate cyclase HPM96_09160 ENOG4106KTS Inner membrane protein yeaI HPM96_09170 ENOG4105CYN Serine protein kinase HPM96_09175 ENOG4105GNX MltA-interacting MipA family protein HPM96_09180 ENOG4105CV8 reductase HPM96_09185 ENOG4105DSB aldose 1-epimerase HPM96_09190 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase HPM96_09200 ENOG4105VUT cytoplasmic protein HPM96_09205 ENOG4105CPQ Dehydrogenase HPM96_09210 ENOG4107TE1 transport protein HPM96_09215 ENOG4105CPQ Dehydrogenase HPM96_09220 ENOG4105D2N Aldolase HPM96_09225 ENOG4107UH8 sugar kinase HPM96_09230 ENOG4105CPC Aldo Keto reductase HPM96_09235 ENOG4105E98 transcriptional regulator DeoR family HPM96_09240 ENOG4108KUU Inner membrane metabolite transport protein ydjE HPM96_09245 ENOG4108RWI nicotinamidase HPM96_09250 ENOG4105HDK L-asparaginase HPM96_09255 ENOG4105D07 Signal peptide peptidase, SppA HPM96_09260 ENOG41069NU Nitroreductase HPM96_09265 ENOG4105D4F Synthesizes selenophosphate from selenide and ATP (By similarity) HPM96_09270 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) HPM96_09275 ENOG4105D82 Glutamate dehydrogenase HPM96_09280 ENOG4105MTM Protein of unknown function (DUF1496) HPM96_09285 ENOG4105M6F mutator MutT protein HPM96_09290 ENOG4108T9J Cdp-alcohol phosphatidyltransferase HPM96_09295 ENOG4107RM6 sulfurtransferase HPM96_09300 ENOG4108VGW abc transporter atp-binding protein HPM96_09305 ENOG4105CXZ ABC transporter, permease HPM96_09310 ENOG4105VNH ABC transporter solute-binding protein HPM96_09315 ENOG4107ZN8 Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) HPM96_09320 ENOG4108N5C SNARE associated Golgi protein-related protein HPM96_09325 ENOG4108KCW iron-sulfur cluster binding HPM96_09330 ENOG4108RSN SNARE associated Golgi HPM96_09335 ENOG4105CGK Exodeoxyribonuclease III HPM96_09355 ENOG4105EY2 Catalyzes the hydrolysis of N(2)-succinylarginine into N(2)-succinylornithine, ammonia and CO(2) (By similarity) HPM96_09365 ENOG4108SPG Periplasmic Protein HPM96_09375 ENOG4105DKD Incises the DNA at the 3' side of a lesion during nucleotide excision repair. Incises the DNA farther away from the lesion than UvrC. Not able to incise the 5' site of a lesion. When a lesion remains because UvrC is not able to induce the 3' incision, Cho incises the DNA. Then UvrC makes the 5' incision. The combined action of Cho and UvrC broadens the substrate range of nucleotide excision repair (By similarity) HPM96_09385 ENOG4105KKI DNA-binding transcriptional activator OsmE HPM96_09390 ENOG4105VZJ PTS System HPM96_09395 ENOG4105CK1 PTS System HPM96_09400 ENOG4105VCP PTS System HPM96_09405 ENOG4105EZV Transcriptional regulator HPM96_09410 ENOG4105F8D glycoside hydrolase family 4 HPM96_09415 ENOG410901P UPF0249 protein HPM96_09420 ENOG4105CH6 catalase HPM96_09435 ENOG4108ETY sodium dicarboxylate symporter HPM96_09440 ENOG4107K5X Membrane-bound metal-dependent hydrolase HPM96_09445 ENOG4107UW8 HAD-superfamily hydrolase subfamily IA variant 3 HPM96_09450 ENOG4107PN8 YfeABCD locus regulator HPM96_09460 ENOG4105P10 Uncharacterized protein ydiZ HPM96_09465 ENOG4105DE4 1-phosphofructokinase HPM96_09470 ENOG4108NE3 Salt-induced outer membrane protein HPM96_09490 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) HPM96_09495 ENOG41082NX 50s ribosomal protein l35 HPM96_09530 ENOG4108V06 Glutathione peroxidase HPM96_09540 ENOG4108QBX (LipO)protein HPM96_09545 ENOG4108TC0 Diguanylate phosphodiesterase HPM96_09560 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) HPM96_09570 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) HPM96_09575 ENOG4107QPK )-transporter HPM96_09580 ENOG4105C5I Dehydrogenase HPM96_09590 ENOG41061TZ Short-chain dehydrogenase reductase Sdr HPM96_09595 ENOG4105CEY Amp-dependent synthetase and ligase HPM96_09600 ENOG41090P5 ferredoxin-like protein HPM96_09605 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase HPM96_09610 ENOG4105C10 Electron transfer flavoprotein HPM96_09615 ENOG4105CV7 Electron transfer flavoprotein HPM96_09620 ENOG4105W4W Transcriptional regulator HPM96_09625 ENOG4105C1G acyl-Coa dehydrogenase HPM96_09630 ENOG4107R0K CoA transferase having broad substrate specificity for short-chain acyl-CoA thioesters with the activity decreasing when the length of the carboxylic acid chain exceeds four carbons (By similarity) HPM96_09645 ENOG4105EMV Major Facilitator HPM96_09650 ENOG4105EMV Major Facilitator HPM96_09655 ENOG4105SUA Ydil protein HPM96_09665 ENOG4105IPI Membrane HPM96_09670 ENOG4105CQB FAD linked oxidase domain protein HPM96_09675 ENOG4105KA0 thioesterase Superfamily protein HPM96_09680 ENOG410671Z uncharacterized protein ydiH HPM96_09685 ENOG4108Z4V iron-sulfur cluster assembly HPM96_09690 ENOG4105DIW FeS assembly protein SUFB HPM96_09695 ENOG4105C3K feS assembly ATPase SufC HPM96_09700 ENOG4105JRK feS assembly protein SufD HPM96_09715 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein HPM96_09720 ENOG4105KMX major outer membrane lipoprotein HPM96_09725 ENOG4105CA9 Pyruvate kinase HPM96_09730 ENOG4105RFR Protein of unknown function (DUF2767) HPM96_09735 ENOG4108PU5 4fe-4S ferredoxin, iron-sulfur binding domain protein HPM96_09740 ENOG4105WE2 aldehyde ferredoxin oxidoreductase HPM96_09745 ENOG4105JVW HPM96_09750 ENOG4108393 oxidoreductase Fe-S subunit HPM96_09755 ENOG4108NWD Cytochrome HPM96_09760 ENOG4108Y7C Conserved Protein HPM96_09765 ENOG4108KTU conserved protein with FAD NAD(P)-binding domain HPM96_09770 ENOG4105N0V mono-oxygenase ydhR HPM96_09795 ENOG4108R6K riboflavin synthase, subunit alpha HPM96_09800 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase HPM96_09805 ENOG4105CZQ inner membrane transport protein YdhC HPM96_09810 ENOG4105F52 Transcriptional regulator HPM96_09825 ENOG4105F27 Major Facilitator HPM96_09830 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) HPM96_09835 ENOG4105K4H Nlp p60 protein HPM96_09840 ENOG4105M2J Glutaredoxin HPM96_09845 ENOG4107QRT dEAD DEAH box helicase HPM96_09855 ENOG4108UYE Lactoylglutathione lyase HPM96_09860 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HPM96_09865 ENOG4108WUH Transcriptional regulator, TetR family HPM96_09870 ENOG4105XZD Fe-S protein HPM96_09875 ENOG4107RGM aldo keto reductase HPM96_09880 ENOG4108Z7T Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) HPM96_09885 ENOG4105DSW Fusaric acid resistance protein HPM96_09890 ENOG4105Y49 secretion protein, HlyD family HPM96_09905 ENOG4108XTF Outer Membrane Lipoprotein HPM96_09915 ENOG410642K Lysozyme inhibitor HPM96_09930 ENOG4107XGF functions in a salvage pathway. Uses pyridoxamine (By similarity) HPM96_09935 ENOG4108K3A Glutathione S-transferase HPM96_09940 ENOG4105DUX Transporter HPM96_09945 ENOG4105CSM endonuclease III HPM96_09955 ENOG4108UQQ Electron transport complex HPM96_09980 ENOG4105M9B inner membrane protein ydgK HPM96_09985 ENOG4105QZ5 OriC-binding nucleoid-associated protein HPM96_09990 ENOG4106C6R beta-lactam resistance protein HPM96_09995 ENOG4105D9R oxidoreductase HPM96_10005 ENOG4105C87 Aminotransferase class I and II HPM96_10010 ENOG4105CI1 PTS System HPM96_10015 ENOG4107P2S Transcriptional regulator HPM96_10020 ENOG4107ZQV short-chain dehydrogenase reductase HPM96_10025 ENOG4105XEA Tetr family transcriptional regulator HPM96_10030 ENOG4105CNT hydrolase family 2 HPM96_10035 ENOG4105CT4 transporter HPM96_10040 ENOG4108QNI outer membrane porin protein HPM96_10045 ENOG4106J39 exported protein HPM96_10050 ENOG4105EIP mannose-6-phosphate isomerase HPM96_10055 ENOG4107GFK fumarate HPM96_10060 ENOG4105C9Q fumarate hydratase class II HPM96_10070 ENOG4105JJR Histidine kinase HPM96_10075 ENOG4107EXC regulatoR HPM96_10080 ENOG4105RA2 Membrane HPM96_10090 ENOG4105D5Q Arginine ornithine antiporter HPM96_10095 ENOG4105C5D exported protein HPM96_10100 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) HPM96_10105 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) HPM96_10110 ENOG4105DSF transport protein HPM96_10125 ENOG4105CVW peptidase s1 and s6 chymotrypsin hap HPM96_10140 ENOG4105D94 Major Facilitator Superfamily HPM96_10145 ENOG4106NZI LysR family Transcriptional regulator HPM96_10150 ENOG4105DAG ROK family HPM96_10155 ENOG4105EWW Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) HPM96_10165 ENOG4108NEM leader-binding protein dmsD HPM96_10170 ENOG4107KGK dmso reductase anchor subunit HPM96_10175 ENOG4105QAX Iron-sulfur HPM96_10180 ENOG4105C3J Cysteine desulfurase HPM96_10185 ENOG4107QY8 reductase HPM96_10190 ENOG4105KBG Protein of unknown function (DUF1161) HPM96_10200 ENOG4108MK9 spermidine N(1)-acetyltransferase HPM96_10215 ENOG4105CXK mandelate racemase muconate lactonizing HPM96_10220 ENOG4105CPQ Dehydrogenase HPM96_10230 ENOG4105DEI Mannitol dehydrogenase HPM96_10235 ENOG41061EV selenium-binding protein YdfZ HPM96_10240 ENOG4107XBN GntR Family Transcriptional Regulator HPM96_10245 ENOG4105EMU Dehydrogenase HPM96_10250 ENOG4105DGW oligopeptidase A HPM96_10255 ENOG4108YDI single-species biofilm formation on inanimate substrate HPM96_10260 ENOG4105FSR swimming returnes to normal when residues 206-207 are both mutated to Ala. Overexpression also leads to a reduction in flagellar abundance and a 20-fold increase in c-di- GMP levels in vivo. Required for aminoglycoside-mediated induction of biofilm formation, it also plays a lesser role in biofilm production in response to other classes of translation inhibitors. The c-di-GMP produced by this enzyme up-regulates poly-GlcNAc production as well as the biofilm synthesis protein PgaD, although c-di-GMP is probably not the main inducing principle. Cyclic-di- GMP is a second messenger which controls cell surface-associated traits in bacteria HPM96_10280 ENOG4105E5W Transporter HPM96_10285 ENOG4108594 Permease of the drug metabolite transporter HPM96_10290 ENOG4105FDP GntR family transcriptional regulator HPM96_10305 ENOG4105VCP PTS System HPM96_10315 ENOG4105CS2 ec 3.2.1.21 HPM96_10320 ENOG4106DNR multiple antibiotic resistance protein HPM96_10325 ENOG4108XW0 May be a transcriptional activator of genes involved in the multiple antibiotic resistance (Mar) phenotype. It can also activate genes such as sodA, zwf and micF HPM96_10330 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes HPM96_10350 ENOG4105EGI Transcriptional regulator HPM96_10355 ENOG4105C26 Dehydrogenase HPM96_10360 ENOG4105CSV Glutaminase HPM96_10365 ENOG4105M0C cytoplasmic protein HPM96_10370 ENOG4105BZU Histidine kinase HPM96_10380 ENOG4105FFC UPF0187 protein HPM96_10390 ENOG4105K34 Involved in the degradation of phospho-AI-2, thereby terminating induction of the lsr operon and closing the AI-2 signaling cycle. Catalyzes the cleavage of phosphorylated 4,5- dihydroxy-2,3-pentanedione (P-DPD) to 2-phosphoglycolic acid (PG) and another three-carbon compound HPM96_10425 ENOG4108EMV Catalyzes the phosphorylation of autoinducer 2 (AI-2) to phospho-AI-2, which subsequently inactivates the transcriptional regulator LsrR and leads to the transcription of the lsr operon. Phosphorylates the ring-open form of 4,5-dihydroxy-2,3- pentanedione (DPD), which is the precursor to all AI-2 signaling molecules, at the C5 position (By similarity) HPM96_10445 ENOG4108RQP Major type 1 subunit fimbrin HPM96_10450 ENOG4108NAE Fimbrial chaperone protein HPM96_10455 ENOG4105CW0 outer membrane usher protein HPM96_10460 ENOG4108WDE Fimbrial protein HPM96_10465 ENOG4106318 fimbrial-like protein YdeR HPM96_10470 ENOG4106PIH fimbrial-like protein ydeQ HPM96_10475 ENOG4107QKC Oxidoreductase alpha (molybdopterin) subunit HPM96_10490 ENOG4105ENH Sulfatase HPM96_10495 ENOG4105C4X radical SAM domain protein HPM96_10550 ENOG4108HWY Beta-lactamase HPM96_10565 ENOG4108BUD transposase HPM96_10570 ENOG4105KT5 UmuD protein HPM96_10575 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) HPM96_10585 ENOG4108BUD transposase HPM96_10605 ENOG4108R0M Aminoglycoside HPM96_10615 ENOG4108BUD transposase HPM96_10625 ENOG4108BUD transposase HPM96_10635 ENOG4105BZU Histidine kinase HPM96_10665 ENOG4108VSE mercuric transport protein HPM96_10670 ENOG4105W1Y Transcriptional regulator HPM96_10685 ENOG4105PE1 Receptor HPM96_10690 ENOG4107RAN Peptidase, M16 HPM96_10695 ENOG4105CVK Glutamate decarboxylase HPM96_10700 ENOG4105E5D amino acid HPM96_10705 ENOG4105F32 YngK protein HPM96_10715 ENOG4105BZU Histidine kinase HPM96_10720 ENOG4108UQS dipeptidase HPM96_10725 ENOG4105DEF Extracellular solute-binding protein, family 5 HPM96_10730 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HPM96_10735 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HPM96_10740 ENOG4105C3U ABC transporter HPM96_10745 ENOG4107H6U ABC transporter HPM96_10750 ENOG4108Z9K Osmotically inducible protein HPM96_10755 ENOG4105TPS biofilm-dependent modulation protein HPM96_10760 ENOG4107AV5 Although this protein associates with the 30S subunit of the ribosome it is not considered to be a bona fide ribosomal protein HPM96_10770 ENOG4105DQ4 alcohol dehydrogenase HPM96_10780 ENOG41084S7 Plasmid maintenance system antidote protein HPM96_10785 ENOG4108MG3 formate dehydrogenase HPM96_10790 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein HPM96_10800 ENOG4105RPH Inner membrane protein YddG HPM96_10810 ENOG4108UI3 Leucine Rich repeat HPM96_10815 ENOG4108UI3 Leucine Rich repeat HPM96_10820 ENOG4107QND Nitrite extrusion protein HPM96_10825 ENOG4105CRU nitrate reductase, alpha subunit HPM96_10830 ENOG4108IUE nitrate reductase beta subunit HPM96_10835 ENOG4108NZN Respiratory nitrate reductase 2 delta chain HPM96_10840 ENOG4105D0D Nitrate reductase 2, gamma subunit HPM96_10845 ENOG4105JAB phenazine biosynthesis protein, phzf family HPM96_10855 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase HPM96_10860 ENOG4108MEJ flavin reductase domain protein HPM96_10870 ENOG4105EUZ Beta-lactamase domain protein HPM96_10880 ENOG4108N27 Glutathione S-transferase HPM96_10885 ENOG4105C85 amino acid HPM96_10890 ENOG4108NS2 receptor HPM96_10895 ENOG4105CHB tonB-dependent Receptor HPM96_10900 ENOG4108WYP Transcriptional regulator HPM96_10905 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein HPM96_10910 ENOG4108Z7F N-acetyltransferase HPM96_10915 ENOG4108T9Y Inner membrane protein ydcZ HPM96_10920 ENOG4105R71 cytoplasmic protein HPM96_10925 ENOG410654E Membrane HPM96_10940 ENOG4105NRK Binding-protein-dependent transport systems, inner membrane component HPM96_10945 ENOG4105D81 ABC transporter, permease HPM96_10950 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HPM96_10955 ENOG4107TYH extracellular solute-binding protein family 1 HPM96_10960 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HPM96_10970 ENOG4105RR0 Protein of unknown function (DUF2554) HPM96_10975 ENOG4105CFP Peptidase U32 HPM96_10980 ENOG4108JCI Transcriptional regulator HPM96_10985 ENOG4105DKK Benzoate HPM96_10990 ENOG4105D7V transposase HPM96_11000 ENOG4108KKZ (LipO)protein HPM96_11005 ENOG41088CC tellurite resistance protein tehB HPM96_11010 ENOG4108NKP c4-dicarboxylate transporter malic acid transport protein HPM96_11015 ENOG4107WE3 acetyltransferase YdcK HPM96_11020 ENOG4108Z9I -acetyltransferase HPM96_11025 ENOG4105Z2P Protein of unknown function (DUF465) HPM96_11035 ENOG4105E32 cytoplasmic protein HPM96_11040 ENOG4105DDW LysR family Transcriptional regulator HPM96_11045 ENOG4105C8Q Methyl-accepting chemotaxis HPM96_11055 ENOG4107NK6 Hok/gef family HPM96_11060 ENOG4105UPP uncharacterized protein ydcA HPM96_11065 ENOG4105CPW cytochrome b561 HPM96_11070 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase HPM96_11075 ENOG4105C26 Dehydrogenase HPM96_11080 ENOG4107DB1 DUF218 domain HPM96_11085 ENOG4105CQ7 ATP-dependent helicase HPM96_11095 ENOG41077RS Phosphatase HPM96_11100 ENOG4105E8V Alpha Beta Hydrolase Fold protein HPM96_11105 ENOG4108HPI phosphatidate Cytidylyltransferase HPM96_11110 ENOG4108UMZ Cdp-alcohol phosphatidyltransferase HPM96_11120 ENOG4107S5I aldo keto reductase HPM96_11125 ENOG4108Z0R Transferase HPM96_11130 ENOG4105V9J phenylacetic acid degradation operon negative regulatory protein HPM96_11135 ENOG4108WFR AraC Family Transcriptional Regulator HPM96_11140 ENOG4105WXT Conserved Protein HPM96_11145 ENOG410689M (LipO)protein HPM96_11150 ENOG4107H52 Dicarboxylate transport HPM96_11155 ENOG4105C5I Dehydrogenase HPM96_11160 ENOG41090X5 Heat shock protein hslJ HPM96_11165 ENOG4105IKK cytoplasmic protein HPM96_11170 ENOG4105D95 Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity) HPM96_11175 ENOG4105FCK Membrane HPM96_11180 ENOG4108RW8 Universal stress protein F HPM96_11190 ENOG4105C1J atp-dependent rna helicase HPM96_11200 ENOG4105BZU Histidine kinase HPM96_11205 ENOG4108DG9 Smr protein MutS2 HPM96_11210 ENOG4106KR7 LysR family Transcriptional regulator HPM96_11215 ENOG4105CH2 amidohydrolase HPM96_11220 ENOG4107RT5 aminobenzoyl-glutamate utilization protein B HPM96_11225 ENOG4105CFC Transporter HPM96_11230 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) HPM96_11235 ENOG4105DS0 Transcriptional regulator, Crp Fnr family HPM96_11240 ENOG4105Q9Y Universal stress protein HPM96_11245 ENOG4105S5I Membrane HPM96_11250 ENOG4105D64 Mechanosensitive ion channel HPM96_11255 ENOG4107QSI ABC, transporter HPM96_11260 ENOG4105KXI murein peptide amidase A HPM96_11265 ENOG4107S8C mandelate racemase muconate lactonizing HPM96_11270 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) HPM96_11275 ENOG4108JU8 Transcriptional regulator HPM96_11285 ENOG4105CM6 amino acid regulated cytosolic protein HPM96_11290 ENOG4105FKQ transcriptional regulator HPM96_11295 ENOG4107EFV Outer membrane protein G HPM96_11300 ENOG4108IJ9 (ABC) transporter HPM96_11305 ENOG4107URF beta-phospho-glucomutase HPM96_11310 ENOG4105C71 hydrolase family 65, central catalytic HPM96_11315 ENOG4105CK5 oxidoreductase HPM96_11320 ENOG4107TYA transient receptor potential locus HPM96_11325 ENOG4107RRD Dehydrogenase HPM96_11330 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component HPM96_11335 ENOG4105HS6 binding-protein-dependent transport systems inner membrane Component HPM96_11340 ENOG4105WEM extracellular solute-binding protein HPM96_11345 ENOG4107QW3 Sucrose phosphorylase HPM96_11350 ENOG4105K8Z Phage shock protein HPM96_11355 ENOG4105NNG Peripheral inner membrane phage-shock protein HPM96_11360 ENOG4105FM1 phage shock protein C HPM96_11365 ENOG4105YYT phage shock protein B HPM96_11370 ENOG41087YS Phage shock protein A HPM96_11375 ENOG4105E51 psp operon transcriptional activator HPM96_11380 ENOG4108JPW Aminotransferase HPM96_11385 ENOG4105CJP fad dependent oxidoreductase HPM96_11390 ENOG4105C26 Dehydrogenase HPM96_11395 ENOG4107VRI Transcriptional regulator HPM96_11400 ENOG4108Z86 Glutamine amidotransferase HPM96_11405 ENOG4105CFQ glutamine synthetase HPM96_11415 ENOG4105CUB amino acid HPM96_11420 ENOG4105N0E Protein of unknown function (DUF2543) HPM96_11425 ENOG4108HIY periplasmic HPM96_11430 ENOG4108I5W peptide transport system, permease protein HPM96_11435 ENOG4108EU3 peptide transport system, permease HPM96_11440 ENOG4108JQ3 Peptide ABC transporter ATP-binding protein HPM96_11445 ENOG4108JQ2 peptide transport system atp-binding protein HPM96_11450 ENOG4105C2C drug resistance transporter, Bcr CflA HPM96_11455 ENOG4105ENJ RND efflux system, outer membrane lipoprotein HPM96_11460 ENOG4105BZS acriflavin resistance protein HPM96_11465 ENOG4105C1P efflux transporter, rnd family, mfp subunit HPM96_11470 ENOG41067SE Tetr family transcriptional regulator HPM96_11475 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH HPM96_11480 ENOG4105Q4T oxidoreductase HPM96_11495 ENOG4105BZU Histidine kinase HPM96_11500 ENOG410643D UPF0509 protein HPM96_11505 ENOG4105N2W Transcriptional regulator HPM96_11515 ENOG4108ZJT translation initiation factor, Sui1 HPM96_11525 ENOG4105CFV Tetratricopeptide repeat protein HPM96_11530 ENOG4105Q4A inner membrane protein yciS HPM96_11535 ENOG4105EYK Phosphatidylglycerophosphatase B HPM96_11545 ENOG4107QM5 aconitate hydratase HPM96_11565 ENOG4107R11 Transcriptional regulator HPM96_11570 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) HPM96_11575 ENOG4105RKX Protein of unknown function (DUF2498) HPM96_11580 ENOG4105ERU peptidase HPM96_11585 ENOG4105UBK short-chain dehydrogenase reductase HPM96_11590 ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase HPM96_11605 ENOG4105FE9 pseudouridine synthase HPM96_11610 ENOG4105EG3 transmembrane signal peptide protein HPM96_11615 ENOG4107RTD sua5 ycio yrdc ywlc family protein HPM96_11620 ENOG4105DB7 PHP domain protein HPM96_11630 ENOG4105CRQ synthase (Component I) HPM96_11635 ENOG4108EFP Anthranilate synthase component II HPM96_11640 ENOG4105DK0 Indole-3-glycerol phosphate synthase HPM96_11660 ENOG4108Z9Z response to DNA damage stimulus HPM96_11665 ENOG4108N8X transition metal ion binding HPM96_11670 ENOG4105EIF outer membrane protein W HPM96_11690 ENOG4105NAU thioesterase Superfamily protein HPM96_11695 ENOG410822N TonB family HPM96_11700 ENOG4105K9H YciI-like protein HPM96_11705 ENOG4107SVH Potassium channel protein HPM96_11725 ENOG4108JQ7 (ABC) transporter HPM96_11730 ENOG4105C3U ABC transporter HPM96_11735 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HPM96_11740 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HPM96_11745 ENOG4108J59 Extracellular solute-binding protein, family 5 HPM96_11755 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein HPM96_11760 ENOG4105C0A alcohol dehydrogenase HPM96_11765 ENOG4105VNT transposase (IS4 family) protein HPM96_11770 ENOG4107104 thymidine kinase HPM96_11775 ENOG4108SAU DNA-binding protein H-ns HPM96_11780 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase HPM96_11785 ENOG4105I93 response regulator HPM96_11790 ENOG4105D78 K07001 NTE family protein HPM96_11800 ENOG4105CIY formyltetrahydrofolate deformylase HPM96_11830 ENOG41076YT nitrate reductase, gamma subunit HPM96_11835 ENOG4105R3A Nitrate reductase HPM96_11840 ENOG4108IUE nitrate reductase beta subunit HPM96_11845 ENOG4105CRU nitrate reductase, alpha subunit HPM96_11850 ENOG4105DQQ Major facilitator superfamily MFS_1 HPM96_11855 ENOG4105BZU Histidine kinase HPM96_11860 ENOG4105WH1 Two component transcriptional regulator luxr family HPM96_11865 ENOG4105ID0 Putative invasin HPM96_11870 ENOG41090EX DsrE family HPM96_11875 ENOG4108NH8 Cation transport protein HPM96_11880 ENOG4105WS7 Cation transport regulator HPM96_11885 ENOG4105EWV Sodium calcium exchanger membrane region HPM96_11910 ENOG41063JG Transcriptional regulator HPM96_11915 ENOG4108YY7 Invasion gene expression up-regulator SirB HPM96_11920 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) HPM96_11945 ENOG4105C5T Phosphoribosyl pyrophosphate synthase HPM96_11950 ENOG4105CHH sulfate transporter HPM96_11955 ENOG4105MGX transcription activated by CRP (cyclic AMP receptor protein), a global transcription factor involved in regulation of metabolism in enteric bacteria HPM96_11965 ENOG4105C3G gtp-binding protein HPM96_11975 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family HPM96_11980 ENOG4105CMT Dihydroxyacetone kinase HPM96_11985 ENOG4108UTZ Dihydroxyacetone kinase HPM96_11990 ENOG4105VDH Dihydroxyacetone kinase HPM96_12005 ENOG4105S10 periplasmic binding protein HPM96_12010 ENOG4105EHG Permease protein HPM96_12015 ENOG4105E0A ABC, transporter HPM96_12020 ENOG4108BSC Methyltransferase HPM96_12025 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase HPM96_12040 ENOG4108T7K Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Increasing levels of c-di-GMP lead to decreased motility (By similarity) HPM96_12050 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A HPM96_12070 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) HPM96_12080 ENOG4105ED1 spovr family HPM96_12095 ENOG410635M Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein (By similarity) HPM96_12100 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) HPM96_12105 ENOG4105KT5 UmuD protein HPM96_12110 ENOG4106PXS Toxin, which has some hemolytic activity towards mammalian cells. Acts by forming a pore-like structure upon contact with mammalian cells HPM96_12120 ENOG4105FBJ fumarylacetoacetate (faa) hydrolase HPM96_12130 ENOG41066UD Inhibits activity of g-type lysozyme, which confers increased lysozyme tolerance to the bacterium HPM96_12135 ENOG4105S66 prophage protein HPM96_12145 ENOG4107QMS site-determining protein HPM96_12185 ENOG410658X HPM96_12200 ENOG4105BZU Histidine kinase HPM96_12205 ENOG410738I uncharacterized protein ymgC HPM96_12215 ENOG41077SS Probably a connector protein for RcsB C regulation of biofilm formation, providing additional signal input into the two- component signaling pathway. May serve to stimulate biofilm maturation, probably via the Rcs phosphorelay. Mild overexpression at 16 degrees Celsius increases the production of colanic acid, an exopolysaccharide and matrix component, and reduces adhesive curli fimbriae expression. Both of these effects require RcsB HPM96_12220 ENOG4105WKE Probably a connector protein for RcsB C regulation of biofilm formation, providing additional signal input into the two- component signaling pathway. Partially antagonizes the activities of YmgA and AriR, proteins that, via the Rcs phosphorelay, promote the synthesis of colanic acid, an exopolysaccharide and matrix component HPM96_12225 ENOG4105BZU Histidine kinase HPM96_12230 ENOG4108XDN Transcriptional regulator HPM96_12235 ENOG41064WM Uncharacterized protein YcgX HPM96_12250 ENOG4108HMX isocitrate dehydrogenase (NADP) HPM96_12275 ENOG4107QTF adenylosuccinate lyase HPM96_12280 ENOG4105XJC Two component transcriptional regulator (Winged helix family HPM96_12285 ENOG4105IFJ Histidine kinase HPM96_12290 ENOG4105EZE Cupin 4 family protein HPM96_12300 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HPM96_12310 ENOG4105D38 putrescine abc transporter HPM96_12315 ENOG4107RUE extracellular solute-binding protein family 1 HPM96_12330 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) HPM96_12340 ENOG4105D60 lipoprotein releasing system transmembrane protein HPM96_12345 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) HPM96_12350 ENOG4105D60 lipoprotein releasing system transmembrane protein HPM96_12355 ENOG4105IQC Inner membrane protein YcfT HPM96_12360 ENOG4108JA2 transcriptioN-repair coupling factor HPM96_12365 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein HPM96_12370 ENOG4105RC8 Reduces the permeability of the outer membrane to copper. Seems to be involved in the regulation of biofilm formation. May decrease biofilm formation by repressing cell-cell interaction and cell surface interaction HPM96_12375 ENOG4108IND Tetr family transcriptional regulator HPM96_12380 ENOG4107MBR 17 kDa surface antigen HPM96_12385 ENOG4105CEP NADH dehydrogenase HPM96_12405 ENOG4108WEF Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b) (By similarity) HPM96_12410 ENOG41090DQ Lipoprotein HPM96_12415 ENOG4105K59 histidine triad (HIT) protein HPM96_12420 ENOG4105CNM Receptor HPM96_12425 ENOG4105CI1 PTS System HPM96_12430 ENOG4105F8V Hydrolase, tatD family HPM96_12435 ENOG4107QRG dna polymerase iii HPM96_12445 ENOG4105HHA aminodeoxychorismate lyase HPM96_12450 ENOG4105YAZ 4-amino-4-deoxychorismate lyase HPM96_12455 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) HPM96_12460 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) HPM96_12465 ENOG4105CHR reductase HPM96_12470 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase HPM96_12490 ENOG4105FCQ metal-binding, possibly nucleic acid-binding protein HPM96_12495 ENOG4108UHJ MAF-like protein HPM96_12500 ENOG4105EI2 Pseudouridine synthase HPM96_12505 ENOG4107QQB Ribonuclease E HPM96_12520 ENOG4105DTJ flagellar hook-associated protein HPM96_12525 ENOG4105E1Q flagellar hook-associated protein HPM96_12530 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj HPM96_12545 ENOG4105CGA flagellar basal-body rod protein FlgG HPM96_12550 ENOG4108KPB Flagellar basal-body rod protein FlgF HPM96_12555 ENOG4105BZE flagellar hook protein, FlgE HPM96_12560 ENOG4105W00 Flagellar hook capping protein HPM96_12565 ENOG4108ZC9 flagellar basal-body rod protein flgc HPM96_12570 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) HPM96_12575 ENOG4105CKS Flagella basal body P-ring formation protein flgA HPM96_12580 ENOG4105M9M anti-sigma28 factor FlgM HPM96_12585 ENOG4105QVD Flagella synthesis protein FlgN HPM96_12590 ENOG4105CJR Integral membrane protein (MviN HPM96_12595 ENOG4105EP9 oxidoreductase HPM96_12605 ENOG4105D9U N-acetyltransferase HPM96_12615 ENOG4105E9S glutaredoxin 2 HPM96_12620 ENOG4105F3T (LipO)protein HPM96_12630 ENOG4105MEA DNA damage-inducible protein i HPM96_12635 ENOG4105PVA Biofilm formation regulatory protein BssS HPM96_12640 ENOG4105F76 Sarcosine oxidase HPM96_12645 ENOG4106974 biofilm formation HPM96_12650 ENOG4105DS1 cytochrome b561 HPM96_12655 ENOG4108YYC ycei family HPM96_12665 ENOG4105D1S lipid A biosynthesis HPM96_12675 ENOG4108W47 Acidic protein msyB HPM96_12680 ENOG4105NAC (LipO)protein HPM96_12685 ENOG4105C3A Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs) (By similarity) HPM96_12700 ENOG4107RZC phospholipase d HPM96_12705 ENOG4108UVJ appr-1-p processing domain protein HPM96_12720 ENOG4105G76 Curli are coiled surface structures that assemble preferentially at growth temperatures below 37 degrees Celsius. Curli can bind to fibronectin HPM96_12725 ENOG4108U0V Curli are coiled surface structures that assemble preferentially at growth temperatures below 37 degrees Celsius. Curli can bind to fibronectin. The minor subunit is the nucleation component of curlin monomers HPM96_12730 ENOG41086KC Transcriptional regulator HPM96_12735 ENOG4108XDW curli assembly protein CsgE HPM96_12740 ENOG4108WYR Curli production assembly transport component, CsgF HPM96_12745 ENOG4105P8Q Curli production assembly transport component CsgG HPM96_12750 ENOG4108UQ5 membrane protein YcdZ HPM96_12755 ENOG4107XHZ cytoplasmic chaperone TorD family protein HPM96_12765 ENOG4105JPG D-isomer specific 2-hydroxyacid dehydrogenase HPM96_12775 ENOG4105BZU Histidine kinase HPM96_12780 ENOG4108TUY outer membrane protein PgaA HPM96_12785 ENOG4107BJW polysaccharide deacetylase HPM96_12790 ENOG4105CND Glycosyl transferase, family 2 HPM96_12800 ENOG4105D5M phosphate starvation-inducible protein HPM96_12805 ENOG4105DBE peroxidase HPM96_12820 ENOG4105CK7 Sodium proline symporter HPM96_12830 ENOG4105C26 Dehydrogenase HPM96_12835 ENOG4108R86 Transcriptional regulator HPM96_12845 ENOG4106XMA In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2 (By similarity) HPM96_12870 ENOG4105C2W permease HPM96_12875 ENOG4105XF5 Escherichia coli IMT2125 genomic chromosome, IMT2125 HPM96_12885 ENOG4105XH3 HPM96_12890 ENOG4105D6F Phosphatase HPM96_12915 ENOG4107QY8 reductase HPM96_12920 ENOG4105CUW cytochrome C-TYPE protein HPM96_12925 ENOG4106WF9 DNA-binding transcriptional regulator TorR HPM96_12930 ENOG4108SV3 Tmao reductase system periplasmic protein tort HPM96_12935 ENOG4105BZU Histidine kinase HPM96_12940 ENOG4105HEE Binding Domain protein HPM96_12945 ENOG4106H71 Overexpression increases levels of unsaturated fatty acids and suppresses both the temperature-sensitive fabA6 mutation and cold-sensitive secG null mutation HPM96_12960 ENOG4105VEQ Cold shock protein HPM96_12965 ENOG41060EU Cold shock-like protein HPM96_12970 ENOG4105D6F Phosphatase HPM96_12980 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii HPM96_12985 ENOG4105C4M (Ubiquinol oxidase) subunit I HPM96_12990 ENOG4105MVP hydrogenase-1 operon protein HyaF HPM96_12995 ENOG4108VXY Hydrogenase-1 operon protein HyaE HPM96_13000 ENOG4108USZ hydrogenase HPM96_13005 ENOG4105X7T Ni Fe-hydrogenase, b-type cytochrome subunit HPM96_13010 ENOG4105DPX Hydrogenase, large subunit HPM96_13015 ENOG4105E3S small subunit HPM96_13025 ENOG4108MN8 Membrane HPM96_13030 ENOG4108Z0T Part of a sulfur-relay system (By similarity) HPM96_13035 ENOG4105VSY K01512 acylphosphatase EC 3.6.1.7 HPM96_13050 ENOG4105K4P CoA-binding domain protein HPM96_13065 ENOG41088T4 Helicase IV HPM96_13070 ENOG410901E Membrane HPM96_13075 ENOG4105EM2 membrane HPM96_13080 ENOG4108RZ1 DNA transformation protein HPM96_13090 ENOG4105UYK outer membrane protein a HPM96_13100 ENOG4105DAN ATP-dependent protease HPM96_13110 ENOG4105WFT During stationary phase, converts 70S ribosomes to an inactive dimeric form (100S ribosomes) (By similarity) HPM96_13115 ENOG4108Q2G (LipO)protein HPM96_13120 ENOG4105DY2 Paraquat-inducible protein b HPM96_13125 ENOG4105F1S paraquat-inducible protein a HPM96_13130 ENOG4105C5H ABC transporter HPM96_13140 ENOG4105QVC MOSC domain-containing protein HPM96_13145 ENOG4108T7E Contributes to the efficiency of the cell division process by stabilizing the polymeric form of the cell division protein FtsZ. Acts by promoting interactions between FtsZ protofilaments and suppressing the GTPase activity of FtsZ (By similarity) HPM96_13155 ENOG4106PH7 chaperone HPM96_13160 ENOG4105MX3 Fimbrial HPM96_13165 ENOG4105Q7J Fimbrial HPM96_13170 ENOG4108MDY Fimbrial HPM96_13175 ENOG4105CW0 outer membrane usher protein HPM96_13180 ENOG4106JJN Part of the elfADCG-ycbUVF fimbrial operon, which promotes adhesion of bacteria to different abiotic surfaces. Could be required for the biogenesis of the ElfA fimbriae HPM96_13185 ENOG41071VI Part of the elfADCG-ycbUVF fimbrial operon, which promotes adhesion of bacteria to different abiotic surfaces. ElfA is the major fimbrial subunit produced by this operon HPM96_13190 ENOG4108UZX fmn reductase HPM96_13195 ENOG4105GVF (ABC) transporter HPM96_13205 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component HPM96_13210 ENOG4105E2Y ABC, transporter HPM96_13215 ENOG4105CD8 aminopeptidase N HPM96_13230 ENOG4105FCK Membrane HPM96_13235 ENOG4105CGF Aromatic amino acid aminotransferase HPM96_13240 ENOG4105C5X domain protein HPM96_13245 ENOG4105EAQ (twin-arginine translocation) pathway signal HPM96_13250 ENOG4105DIT ErfK YbiS YcfS YnhG family protein HPM96_13260 ENOG4105DAH Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF (By similarity) HPM96_13270 ENOG4106371 Methyltransferase HPM96_13275 ENOG4107S90 membrAne HPM96_13280 ENOG4107VR7 transferase activity, transferring phosphorus-containing groups HPM96_13295 ENOG4105T0Z Conserved Protein HPM96_13305 ENOG4105BZ1 (ABC) transporter HPM96_13310 ENOG4108EQH DNA internalization-related competence protein ComEC Rec2 HPM96_13320 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) HPM96_13330 ENOG4108K0D peptidase, M48 HPM96_13345 ENOG4107VMU Membrane HPM96_13350 ENOG4105DDY UPF0142 protein ycaO HPM96_13355 ENOG4105TMB Formate nitrite transporter HPM96_13360 ENOG4105C6N Formate acetyltransferase HPM96_13365 ENOG4105F1A Pyruvate formate-lyase HPM96_13370 ENOG4108X0B nad(p)h dehydrogenase (quinone) HPM96_13375 ENOG410642W LysR family Transcriptional regulator HPM96_13380 ENOG4105E5D amino acid HPM96_13390 ENOG4105CHJ isochorismatase hydrolase HPM96_13395 ENOG4107KGK dmso reductase anchor subunit HPM96_13400 ENOG4105QAX Iron-sulfur HPM96_13405 ENOG4107QY8 reductase HPM96_13415 ENOG4105D1H recombination factor protein RarA HPM96_13425 ENOG4105CNU cell division protein FtsK HPM96_13435 ENOG4105C3M thioredoxin reductase HPM96_13440 ENOG4108JJ9 ABC, transporter HPM96_13445 ENOG4108JJ8 (ABC) transporter HPM96_13455 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) HPM96_13465 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit HPM96_13475 ENOG4105VEQ Cold shock protein HPM96_13480 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) HPM96_13485 ENOG4105DJY efflux transporter, rnd family, mfp subunit HPM96_13490 ENOG4108MJ5 VirK protein HPM96_13495 ENOG4105CPB ATP-dependent endonuclease of the OLD family HPM96_13500 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) HPM96_13505 ENOG4105EQR Transposase IS116 IS110 IS902 HPM96_13510 ENOG4105FBT Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity) HPM96_13520 ENOG41067MG lrgb family HPM96_13530 ENOG4107GZ4 SanA protein HPM96_13535 ENOG4105Y9N Membrane HPM96_13540 ENOG4105BZ8 glutamate synthase HPM96_13545 ENOG4107SJI Dehydrogenase HPM96_13550 ENOG4108HWV )-transporter HPM96_13555 ENOG4105C2J ABC transporter HPM96_13560 ENOG4105EMA Periplasmic binding protein LacI transcriptional regulator HPM96_13565 ENOG41060NJ transcriptional regulator HPM96_13570 ENOG4105DHF Membrane HPM96_13580 ENOG4105C4W S-formylglutathione hydrolase HPM96_13590 ENOG4105EJQ L-serine dehydratase HPM96_13595 ENOG4105EAC phosphoserine phosphatase HPM96_13600 ENOG4105CXY transporter HPM96_13605 ENOG4105D05 Receptor HPM96_13610 ENOG4108IQI permease HPM96_13615 ENOG4105DUM transcriptional regulator, lysR family HPM96_13620 ENOG4105HMI Membrane HPM96_13630 ENOG4105DD7 kinase (PfkB family HPM96_13635 ENOG4105D9N nucleoside HPM96_13645 ENOG4108Y4K DNA-binding transcriptional activator HPM96_13650 ENOG4105D9N nucleoside HPM96_13655 ENOG4105D53 Catalyzes the hydrolysis of pseudouridine 5'-phosphate (PsiMP) to ribose 5-phosphate and uracil (By similarity) HPM96_13660 ENOG4105DD7 kinase (PfkB family HPM96_13665 ENOG4105DM4 PTS System HPM96_13670 ENOG4105DE4 1-phosphofructokinase HPM96_13675 ENOG4105DTZ bifunctional PTS system fructose-specific transporter subunit IIA HPr protein HPM96_13680 ENOG4105S8Q sugar efflux transporter HPM96_13685 ENOG4105KRS Proteinase inhibitor HPM96_13695 ENOG4105DEI Mannitol dehydrogenase HPM96_13700 ENOG4105CKI cobalamin synthesis protein HPM96_13705 ENOG41076MN Phosphoesterase, PA-phosphatase related HPM96_13710 ENOG4107TT5 NLP P60 protein HPM96_13715 ENOG4105CXC rtn protein HPM96_13720 ENOG4105E43 Extracellular solute-binding protein, family 5 HPM96_13725 ENOG4108I5X binding-protein-dependent transport systems inner membrane Component HPM96_13730 ENOG4108IYQ Binding-protein-dependent transport systems inner membrane component HPM96_13735 ENOG4108JQ5 ABC transporter HPM96_13740 ENOG4105HG6 HPM96_13745 ENOG4105C2C drug resistance transporter, Bcr CflA HPM96_13750 ENOG4105I08 Pseudouridine synthase HPM96_13755 ENOG4105CFI type iii restriction protein res subunit HPM96_13775 ENOG4105E68 Sulfatase HPM96_13785 ENOG4108MGN ATP-binding component of a transport system HPM96_13790 ENOG4105WH1 Two component transcriptional regulator luxr family HPM96_13795 ENOG4105KWW Biogenesis protein HPM96_13800 ENOG4107QX9 Thiol disulfide interChange protein HPM96_13805 ENOG4105DA4 cytochrome c-type biogenesis protein HPM96_13815 ENOG4105X3C heme exporter protein HPM96_13820 ENOG41060IM Heme exporter protein HPM96_13825 ENOG4105CA5 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes (By similarity) HPM96_13830 ENOG4107EV4 once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system (By similarity) HPM96_13835 ENOG4105CUW cytochrome C-TYPE protein HPM96_13840 ENOG4108ZMS Electron transfer subunit of the periplasmic nitrate reductase complex NapAB (By similarity) HPM96_13845 ENOG4105GXZ Ferredoxin-type protein NapH HPM96_13850 ENOG4108BGM Quinol dehydrogenase periplasmic component HPM96_13860 ENOG41061Q0 Assembly protein for periplasmic nitrate reductase HPM96_13865 ENOG4108ZNS ferredoxin-type protein NapF HPM96_13885 ENOG4105IBP Cyclic peptide transporter HPM96_13890 ENOG4105CF1 Alkylated DNA repair protein HPM96_13895 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) HPM96_13900 ENOG4105CJ2 (LipO)protein HPM96_13905 ENOG4105FCK Membrane HPM96_13910 ENOG4105E3G Phosphotransfer intermediate protein in two-component regulatory system with RcsBC HPM96_13915 ENOG41068CG regulatoR HPM96_13920 ENOG4105BZU Histidine kinase HPM96_13925 ENOG4105BZU Histidine kinase HPM96_13930 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family HPM96_13935 ENOG4107QP7 CoA-transferase subunit A HPM96_13940 ENOG4107QNJ CoA-transferase subunit B HPM96_13945 ENOG4105CRW Short chain fatty acid transporter HPM96_13950 ENOG4105CHU acetyl-coa acetyltransferase HPM96_13955 ENOG4105EDV vault protein HPM96_13960 ENOG41081SK signal peptide protein HPM96_13965 ENOG4107S52 alpha-2-macroglobulin domain protein HPM96_13970 ENOG4108QJJ Protein of unknown function (DUF1175) HPM96_13975 ENOG4107FKF Uncharacterized protein conserved in bacteria (DUF2138) HPM96_13980 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HPM96_13985 ENOG4105CXK mandelate racemase muconate lactonizing HPM96_13995 ENOG4105DRR Transcriptional regulator, GntR family HPM96_14005 ENOG4107GHC outer membrane autotransporter HPM96_14010 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HPM96_14015 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HPM96_14020 ENOG4105XPH Ferredoxin HPM96_14025 ENOG4105FQR PH-inducible protein involved in stress response HPM96_14030 ENOG4105CZM Major Facilitator HPM96_14035 ENOG4105GZI Transcriptional regulator HPM96_14040 ENOG4106MZZ glycerophosphoryl diester phosphodiesterase HPM96_14045 ENOG4105CXY transporter HPM96_14050 ENOG4107R5Y anaerobic glycerol-3-phosphate dehydrogenase, subunit A HPM96_14060 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) HPM96_14065 ENOG4105DNE Transposase HPM96_14080 ENOG4105CSP Major Facilitator Superfamily HPM96_14090 ENOG4107258 Transcriptional regulator HPM96_14100 ENOG4108UII YfaZ family HPM96_14150 ENOG4106GZG polymyxin resistance protein B HPM96_14155 ENOG4105CEY Amp-dependent synthetase and ligase HPM96_14165 ENOG4108IPT Naphthoate synthase HPM96_14180 ENOG4105E4F Isochorismate synthase HPM96_14185 ENOG4105TNS Conserved Protein HPM96_14190 ENOG4107YB6 acetyltransferase, (GNAT) family HPM96_14210 ENOG4105GDX Domain of unknown function (DUF1877) HPM96_14220 ENOG4105C8S subunit m HPM96_14225 ENOG4105D65 subunit l HPM96_14235 ENOG4107UFS subunit j HPM96_14250 ENOG4108IEH NADH dehydrogenase subunit g HPM96_14255 ENOG4107QIZ NADH dehydrogenase HPM96_14260 ENOG4105GKE subunit e HPM96_14280 ENOG4107NQ8 LysR family Transcriptional regulator HPM96_14285 ENOG4105CHM Aminotransferase HPM96_14295 ENOG4107QWE )-transporter HPM96_14300 ENOG4105EVE HAD-superfamily hydrolase subfamily IA variant 3 HPM96_14305 ENOG4105XWI UPF0304 protein HPM96_14315 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) HPM96_14320 ENOG4105C6K Malic enzyme HPM96_14325 ENOG4105CSX c4-dicarboxylate anaerobic carrier HPM96_14330 ENOG4105PTV Nudix Hydrolase HPM96_14335 ENOG4108RE9 Phosphodiesterase HPM96_14340 ENOG4108SHQ Glutathione S-transferase HPM96_14345 ENOG4105CYM Glutathione S-transferase HPM96_14350 ENOG4105KKP D-erythro-7,8-dihydroneopterin triphosphate 2'-epimerase HPM96_14355 ENOG4105ECP epimerase HPM96_14360 ENOG4105DFD Na H antiporter HPM96_14370 ENOG4105DNE Transposase HPM96_14375 ENOG4108JEH abc transporter atp-binding protein HPM96_14380 ENOG4106YG3 ABC transporter HPM96_14385 ENOG4105DSP amino acid AbC transporter HPM96_14390 ENOG4105E89 ABC transporter HPM96_14395 ENOG4105E89 ABC transporter HPM96_14400 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase HPM96_14405 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase HPM96_14410 ENOG4105E96 Colicin v production protein HPM96_14415 ENOG4108S3P Sporulation domain protein HPM96_14420 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase HPM96_14430 ENOG4105DQR SNARE associated Golgi HPM96_14440 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) HPM96_14450 ENOG4106WZ1 flagella biosynthesis regulator HPM96_14455 ENOG4105F9N Major Facilitator Superfamily HPM96_14460 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) HPM96_14470 ENOG4105MH2 YfcL protein HPM96_14475 ENOG4108BPE -transporting atpase HPM96_14480 ENOG4105EJ9 Membrane HPM96_14490 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase HPM96_14495 ENOG4105C76 Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity) HPM96_14520 ENOG4105US4 fimbrial-like protein yfcP HPM96_14525 ENOG4105UGQ Fimbrial HPM96_14530 ENOG4105NEV Fimbrial HPM96_14535 ENOG4108FZ9 Chaperone HPM96_14540 ENOG4106PG1 outer membrane usher protein HPM96_14550 ENOG4108BY2 phosphohistidine phosphatase HPM96_14565 ENOG4105KZW UPF0381 protein HPM96_14570 ENOG4105CKF membrane protein involved in aromatic hydrocarbon degradation HPM96_14580 ENOG410903C (LipO)protein HPM96_14585 ENOG4105S64 Formate nitrite transporter HPM96_14595 ENOG4105DFP Integrase HPM96_14690 ENOG4108N0N Phage Terminase Large Subunit HPM96_14710 ENOG4105SZK Rz endopeptidase from lambdoid prophage DLP12 HPM96_14715 ENOG4105KUS lysozyme HPM96_14750 ENOG4105RWQ Protein of unknown function (DUF1364) HPM96_14865 ENOG41077V0 CPS-53 (KpLE1) prophage HPM96_14895 ENOG4105DFP Integrase HPM96_14920 ENOG4107QRT dEAD DEAH box helicase HPM96_14955 ENOG4108I5G Major Facilitator superfamily HPM96_14960 ENOG4105CPQ Dehydrogenase HPM96_15010 ENOG4105C6F GntR Family Transcriptional Regulator HPM96_15050 ENOG4108W9T type 1 fimbriae regulatory protein HPM96_15055 ENOG4108W9T type 1 fimbriae regulatory protein HPM96_15060 ENOG4105W8I Transcriptional regulator HPM96_15075 ENOG4105C0R drug resistance transporter emrb qaca subfamily HPM96_15080 ENOG4105CW7 secretion protein, HlyD family HPM96_15085 ENOG4108WQH regulatoR HPM96_15090 ENOG4105BZU Histidine kinase HPM96_15095 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F HPM96_15100 ENOG4108N2Y auxin Efflux HPM96_15105 ENOG4105CFN oxalyl-CoA decarboxylase HPM96_15115 ENOG4108V08 YfdX protein HPM96_15125 ENOG4105W9M Membrane HPM96_15130 ENOG4105D1S lipid A biosynthesis HPM96_15140 ENOG4105CHM Aminotransferase HPM96_15145 ENOG4108HRK Histidine kinase HPM96_15150 ENOG4105DY9 regulatoR HPM96_15155 ENOG4108CIP transcriptional regulator HPM96_15160 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) HPM96_15165 ENOG4105CN9 Peptidase m42 family protein HPM96_15170 ENOG4105DC7 peptidase M24 HPM96_15175 ENOG410863U PTS System HPM96_15180 ENOG4105R6B The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane (By similarity) HPM96_15195 ENOG4109076 Conserved Protein HPM96_15205 ENOG4105D9N nucleoside HPM96_15210 ENOG4108KMM Diguanylate cyclase HPM96_15225 ENOG4105HZG regulatoR HPM96_15230 ENOG4105GXM Putative transcription regulator (DUF1323) HPM96_15270 ENOG4105CN8 Transcriptional regulator HPM96_15280 ENOG4105EAA nucleoside HPM96_15285 ENOG4107U5R The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity) HPM96_15290 ENOG4108NFH Sugar hydrolase HPM96_15295 ENOG4108M0I Transcriptional regulator HPM96_15300 ENOG4105DHU Bile acid HPM96_15305 ENOG4105VRT cytoplasmic protein HPM96_15325 ENOG4105C6T cysteine synthase HPM96_15335 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) HPM96_15340 ENOG4105C5Y PTS System HPM96_15350 ENOG4105M0Y HPM96_15355 ENOG4105C6T cysteine synthase HPM96_15360 ENOG4108IJ6 ABC transporter HPM96_15365 ENOG4105ECW sulfate abc transporter HPM96_15370 ENOG4108I5D sulfate abc transporter HPM96_15375 ENOG4108J2H Sulfate ABC transporter periplasmic sulfate-binding protein HPM96_15380 ENOG4105I7Z Short-chain dehydrogenase reductase Sdr HPM96_15395 ENOG4105C5Y PTS System HPM96_15400 ENOG4107S1E Beta-lactamase HPM96_15405 ENOG4105EZR dyp-type peroxidase family protein HPM96_15410 ENOG4105E7K (LipO)protein HPM96_15415 ENOG4105QZU Inner membrane protein YfeZ HPM96_15425 ENOG4108KNB n-acetylmuramoyl-l-alanine amidase HPM96_15435 ENOG4108K3Z AraC family transcriptional regulator HPM96_15440 ENOG4108X49 Ethanolamine utilization protein EutK HPM96_15445 ENOG4106D67 ethanolamine utilization protein HPM96_15455 ENOG4105CPD ethanolamine ammonia-lyase HPM96_15460 ENOG4105DYY Reactivating factor for ethanolamine ammonia lyase HPM96_15465 ENOG4105ENY Ethanolamine utilization protein eutH HPM96_15470 ENOG4105C0A alcohol dehydrogenase HPM96_15475 ENOG4107RWI ethanolamine utilization protein eutJ HPM96_15480 ENOG4108EKI Dehydrogenase HPM96_15485 ENOG4105WVM ethanolamine utilization protein EutN carboxysome structural protein Ccml HPM96_15490 ENOG4105KNY Microcompartments protein HPM96_15495 ENOG4107WUY phosphate acetyltransferase HPM96_15500 ENOG4108PFF ethanolamine utilization cobalamin adenosyltransferase HPM96_15505 ENOG4105NDK ethanolamine utilization protein HPM96_15510 ENOG4106S4J ethanolamine utilization protein EutP HPM96_15515 ENOG4108VJN May be involved in the formation of a specific microcompartment in the cell in which the metabolism of potentially toxic by-products takes place HPM96_15520 ENOG4105C6K Malic enzyme HPM96_15525 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) HPM96_15530 ENOG4105CV1 Transketolase (EC 2.2.1.1) HPM96_15535 ENOG4108PVD exported protein HPM96_15545 ENOG4105BZ8 glutamate synthase HPM96_15550 ENOG4105BZU Histidine kinase HPM96_15555 ENOG4105BZS acriflavin resistance protein HPM96_15565 ENOG4105KUZ arsenate reductase HPM96_15580 ENOG4106KED esterase YpfH HPM96_15590 ENOG4105CGZ zinc metallopeptidase HPM96_15600 ENOG4107EG0 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) HPM96_15610 ENOG4105RH4 Glycine cleavage system transcriptional repressor HPM96_15615 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen HPM96_15620 ENOG4108MFN small subunit of hydrogenase-3, iron-sulfur protein (part of formate hydrogenlyase (FHL) complex) HPM96_15625 ENOG4108JPZ Monovalent cation H antiporter subunit D HPM96_15630 ENOG4107TDF Formate hydrogenlyase subunit 4 HPM96_15635 ENOG4105D65 subunit l HPM96_15640 ENOG4107WQX hydrogenase 4 membrane subunit HPM96_15645 ENOG4108JPZ Monovalent cation H antiporter subunit D HPM96_15650 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HPM96_15660 ENOG4105C47 NADH ubiquinone oxidoreductase 20 kda subunit HPM96_15665 ENOG4105I6X formate hydrogenlyase maturation HPM96_15670 ENOG4108JUA Transcriptional regulator HPM96_15675 ENOG4105TMB Formate nitrite transporter HPM96_15680 ENOG4105C02 permease HPM96_15685 ENOG4105ERG peptidase m48, ste24p HPM96_15690 ENOG4105K89 arsenate reductase HPM96_15695 ENOG4108KZ1 Mediates the interaction of DNA replication inititator protein DnaA with DNA polymerase subunit beta sliding clamp (dnaN). Stimulates hydrolysis of ATP-DnaA to ADP-DnaA, rendering DnaA inactive for reinititation, a process called regulatory inhibition of DnaA or RIDA (By similarity) HPM96_15700 ENOG4105C2W permease HPM96_15710 ENOG4105CXB phosphoribosylaminoimidazole synthetase HPM96_15715 ENOG4108V3E phosphoribosylglycinamide formyltransferase HPM96_15720 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) HPM96_15725 ENOG4105C9X ppx gppa phosphatase HPM96_15730 ENOG4105BZU Histidine kinase HPM96_15740 ENOG41062G3 Protein of unknown function (DUF2633) HPM96_15745 ENOG4108ZMA Outer membrane lipoprotein HPM96_15750 ENOG41066DY Membrane HPM96_15760 ENOG4105NVB glycoside hydrolase, family 19 HPM96_15895 ENOG4108TFU terminase (Small subunit) HPM96_15970 ENOG41076J9 exonuclease VIII HPM96_16005 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) HPM96_16010 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) HPM96_16035 ENOG4105VPD cellular component movement HPM96_16050 ENOG4105N21 Membrane HPM96_16080 ENOG4108JQB penicillin-binding protein 1C HPM96_16085 ENOG4105DN3 alpha-2-macroglobulin domain protein HPM96_16090 ENOG4105KHC sulfurtransferase HPM96_16095 ENOG4105YYA enhanced serine sensitivity protein SseB HPM96_16105 ENOG4105WVQ Fe-S assembly protein IscX HPM96_16110 ENOG4108ZIT Ferredoxin, 2FE-2S HPM96_16130 ENOG4107XTC May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins HPM96_16150 ENOG4105ECY inositol monophosphatase HPM96_16155 ENOG4107XM9 (LipO)protein HPM96_16160 ENOG4108MN2 Stationary phase inducible protein CsiE HPM96_16165 ENOG4105D8G Major Facilitator superfamily HPM96_16170 ENOG4108W5M transcriptional regulator HPM96_16175 ENOG4105FUY alpha subunit HPM96_16200 ENOG4108SB3 DoxX Family HPM96_16205 ENOG4108ZKT aldose 1-epimerase HPM96_16210 ENOG4105CPQ Dehydrogenase HPM96_16215 ENOG4105CNN ABC, transporter HPM96_16220 ENOG4108F37 ATP-binding component of a transport system HPM96_16225 ENOG4105FCA ABC transporter periplasmic-binding protein YphF HPM96_16230 ENOG4107HQ7 repeat protein HPM96_16235 ENOG4108NZE NAGC-like transcriptional regulator HPM96_16245 ENOG4108EGH Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) HPM96_16255 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family HPM96_16260 ENOG4108SKK alpha helix protein HPM96_16265 ENOG4107WP9 Histidine kinase HPM96_16270 ENOG4108ETH Formylglycinamide ribotide synthetase HPM96_16280 ENOG4108Z6B deaminase HPM96_16285 ENOG4105HYY HAD superfamily (Subfamily IF) hydrolase, YfhB HPM96_16290 ENOG4106G6Q Transcriptional regulator HPM96_16295 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding HPM96_16310 ENOG4105CSZ Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity) HPM96_16330 ENOG4105C3F Signal peptidase i HPM96_16340 ENOG4105WMJ Positive regulator of sigma E, RseC MucC HPM96_16345 ENOG4105VQK sigma E regulatory protein, MucB RseB HPM96_16350 ENOG41069PW sigma-e factor negative regulatory protein HPM96_16355 ENOG4105EMN RNA polymerase sigma factor HPM96_16365 ENOG4108IYU L-aspartate oxidase HPM96_16375 ENOG4105C1J atp-dependent rna helicase HPM96_16380 ENOG41090KR LysR family transcriptional Regulator HPM96_16400 ENOG4105EIB trna rrna methyltransferase HPM96_16405 ENOG4105K63 Thioredoxin HPM96_16410 ENOG4106IUH DTW domain containing protein HPM96_16415 ENOG4105CD5 CoA-binding domain protein HPM96_16420 ENOG4105JIM Phosphatidylserine synthase HPM96_16425 ENOG4105T42 (LipO)protein HPM96_16430 ENOG4105CSH Transporter HPM96_16455 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit HPM96_16460 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase HPM96_16465 ENOG4105C34 Pseudouridine synthase HPM96_16470 ENOG4106SNF Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane HPM96_16475 ENOG4105VNT transposase (IS4 family) protein HPM96_16480 ENOG4108WPH sigma 54 modulation protein ribosomal protein S30EA HPM96_16490 ENOG4105CQC Prephenate dehydratase HPM96_16495 ENOG4105EHE chorismate mutase- prephenate dehydrogenase HPM96_16500 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) HPM96_16505 ENOG4105QP9 Protein of unknown function (DUF2799) HPM96_16510 ENOG4108WS1 HPM96_16515 ENOG4108KHX Diguanylate cyclase HPM96_16520 ENOG41090EK ompa motb domain protein HPM96_16545 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY HPM96_16550 ENOG4106KVJ cytochrome C assembly protein HPM96_16555 ENOG4108JU6 CBS domain protein HPM96_16570 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) HPM96_16575 ENOG4105YRI Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) HPM96_16585 ENOG4108Z1B Cyclase dehydrase HPM96_16600 ENOG4108MGN ATP-binding component of a transport system HPM96_16625 ENOG4105E54 alpha-amylase HPM96_16635 ENOG4105D5U fad dependent oxidoreductase HPM96_16640 ENOG4105C26 Dehydrogenase HPM96_16645 ENOG4108JPW Aminotransferase HPM96_16650 ENOG4105C85 amino acid HPM96_16655 ENOG4108PVQ transcriptional regulator HPM96_16660 ENOG4109066 lysm domain bon superfamily protein HPM96_16665 ENOG4105VPI YqaE family transport protein HPM96_16670 ENOG41080HT Transcriptional regulator, arsr family HPM96_16675 ENOG4108V62 Rhodanese domain protein HPM96_16680 ENOG4108X73 DNA- binding protein HPM96_16685 ENOG4108RNS Exports L-alanine (By similarity) HPM96_16690 ENOG4108WMJ Protein of unknown function (DUF2002) HPM96_16695 ENOG4108ZQZ Bacterial protein of unknown function (DUF883) HPM96_16700 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HPM96_16705 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) HPM96_16710 ENOG4105WAZ (Glutaredoxin-like protein) NrdH HPM96_16720 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HPM96_16725 ENOG4107R25 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HPM96_16730 ENOG4108IJ7 Glycine betaine HPM96_16735 ENOG4108HQS Glycine betaine HPM96_16740 ENOG4105GIJ Glycine betaine HPM96_16750 ENOG4108UMN azlc family HPM96_16755 ENOG4105ZED uncharacterized protein ygaH HPM96_16760 ENOG4105NTK Transcriptional repressor Mpra HPM96_16765 ENOG4105CW7 secretion protein, HlyD family HPM96_16770 ENOG4105C0R drug resistance transporter emrb qaca subfamily HPM96_16785 ENOG4105W39 Membrane HPM96_16790 ENOG4107VXZ Hydrolase HPM96_16820 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) HPM96_16840 ENOG4107TH8 cina domain protein HPM96_16845 ENOG4105CVE Lytic murein transglycosylase HPM96_16850 ENOG410787A Pts system, glucitol sorbitol-specific HPM96_16855 ENOG4105DZY Pts system, glucitol sorbitol-specific HPM96_16860 ENOG4105VI0 Pts system, glucitol sorbitol-specific HPM96_16865 ENOG4107QMF Sorbitol-6-phosphate dehydrogenase HPM96_16870 ENOG4105J92 DNA-binding transcriptional activator GutM HPM96_16875 ENOG410804X Transcriptional regulator HPM96_16885 ENOG4108JUA Transcriptional regulator HPM96_16900 ENOG4105C8H hydrogenase maturation protein Hypf HPM96_16905 ENOG4108RC0 Electron transport protein HPM96_16910 ENOG4105DDV Transcriptional regulator (LacI family HPM96_16915 ENOG4105C5Y PTS System HPM96_16920 ENOG4105CS2 ec 3.2.1.21 HPM96_16930 ENOG4108MG9 hydrogenase 3 maturation protease HPM96_16935 ENOG4105I6X formate hydrogenlyase maturation HPM96_16940 ENOG4105C47 NADH ubiquinone oxidoreductase 20 kda subunit HPM96_16945 ENOG4108RG7 formate hydrogenlyase complex iron-sulfur subunit HPM96_16950 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HPM96_16955 ENOG4107TDF Formate hydrogenlyase subunit 4 HPM96_16960 ENOG4107R30 NADH dehydrogenase HPM96_16965 ENOG4108MFN small subunit of hydrogenase-3, iron-sulfur protein (part of formate hydrogenlyase (FHL) complex) HPM96_16970 ENOG4108VRC Formate hydrogenlyase regulatory protein hycA HPM96_16975 ENOG410816D Probably plays a role in a hydrogenase nickel cofactor insertion step (By similarity) HPM96_16980 ENOG4107RSS Hydrogenase accessory protein HypB HPM96_16985 ENOG41083WG hydrogenase assembly chaperone HPM96_16990 ENOG4105CQS hydrogenase expression formation protein HypD HPM96_16995 ENOG4105C45 hydrogenase expression formation protein (HypE) HPM96_17000 ENOG4108JUA Transcriptional regulator HPM96_17010 ENOG4105VXR cytoplasmic protein HPM96_17025 ENOG4105MEW serine threonine protein phosphatase HPM96_17030 ENOG4105KZM cytoplasmic protein HPM96_17035 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) HPM96_17040 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase HPM96_17050 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HPM96_17055 ENOG4108K5P (LipO)protein HPM96_17090 ENOG4105N0Z inner membrane protein ygbE HPM96_17110 ENOG4108MXK alkaline phosphatase isozyme conversion HPM96_17115 ENOG4107635 Hok Gef family protein HPM96_17120 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) HPM96_17135 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase HPM96_17140 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase HPM96_17145 ENOG4105WQV ferredoxin-like protein HPM96_17150 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator HPM96_17155 ENOG4105YBM electron transfer flavoprotein subunit ygcQ HPM96_17160 ENOG4106IKH Electron transfer flavoprotein HPM96_17165 ENOG4105C54 Major Facilitator superfamily HPM96_17170 ENOG4107R3A FAD linked oxidase domain protein HPM96_17175 ENOG4105CHR reductase HPM96_17180 ENOG4108ITV Inner membrane protein yqcE HPM96_17185 ENOG4108CWB sugar kinase ygcE HPM96_17210 ENOG4105WBN Transcriptional regulator (LacI family HPM96_17215 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) HPM96_17225 ENOG4105HA9 of methanol dehydrogenase type HPM96_17235 ENOG4105HA9 of methanol dehydrogenase type HPM96_17250 ENOG4105DXN mazG family HPM96_17255 ENOG4105MZG transcriptional modulator of maze toxin, mazf HPM96_17260 ENOG4106A2Z transcriptional regulator antitoxin, MazE HPM96_17265 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) HPM96_17270 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) HPM96_17275 ENOG4105BZU Histidine kinase HPM96_17280 ENOG4105EQX glucarate dehydratase HPM96_17285 ENOG4105EQX glucarate dehydratase HPM96_17290 ENOG4105DJB Major Facilitator Superfamily HPM96_17295 ENOG4105QDK Flavodoxin HPM96_17300 ENOG4105DR9 pseudouridine synthase HPM96_17305 ENOG4105WP7 tRNA pseudouridine synthase C HPM96_17320 ENOG4105EWT decarboxylase family HPM96_17325 ENOG4105C44 Serine transporter HPM96_17330 ENOG4105EJQ L-serine dehydratase HPM96_17340 ENOG4105C0A alcohol dehydrogenase HPM96_17345 ENOG4107W7X Aldolase HPM96_17350 ENOG4105EDR glucose galactose transporter HPM96_17355 ENOG4105EHF Converts the aldose L-fucose into the corresponding ketose L-fuculose (By similarity) HPM96_17360 ENOG4105CMG Carbohydrate kinase HPM96_17370 ENOG4107EDW L-fucose operon activator HPM96_17380 ENOG4105M08 Membrane HPM96_17385 ENOG4105ETT transcriptional Regulator, LysR family HPM96_17390 ENOG4105M5B (LipO)protein HPM96_17395 ENOG4105C9B Cysteine desulfurase HPM96_17400 ENOG4105P9C Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity) HPM96_17405 ENOG4105CUZ uba thif-type nad fad binding protein HPM96_17410 ENOG4105CA3 membrane-bound lytic murein transglycosylase HPM96_17435 ENOG4105C2X Arabinose 5-phosphate isomerase HPM96_17440 ENOG4105C87 Aminotransferase class I and II HPM96_17445 ENOG4105CI1 PTS System HPM96_17450 ENOG4105CID antiterminator HPM96_17455 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase HPM96_17460 ENOG4108EKC n-acetylglutamate synthase HPM96_17465 ENOG4107QYX exodeoxyribonuclease v alpha HPM96_17470 ENOG4107QKA exodeoxyribonuclease V beta HPM96_17475 ENOG4107QXK peptidase HPM96_17480 ENOG4105DSY exodeoxyribonuclease V, gamma HPM96_17485 ENOG4105RVB Prepilin peptidase dependent protein c HPM96_17490 ENOG4105SEN Protein of unknown function (DUF2509) HPM96_17495 ENOG4105JCS prepilin peptidase dependent protein HPM96_17500 ENOG4105IPU prepilin peptidase dependent protein A HPM96_17515 ENOG4108HRM phosphoenolpyruvate--protein phosphotransferase HPM96_17530 ENOG4105EE5 Membrane protein terC HPM96_17535 ENOG4105SUV lipoprotein YgdR HPM96_17540 ENOG4105CPC Aldo Keto reductase HPM96_17555 ENOG41060NJ transcriptional regulator HPM96_17565 ENOG4105RQF LysR family Transcriptional regulator HPM96_17575 ENOG4107QNK )-transporter HPM96_17580 ENOG4105CHR reductase HPM96_17590 ENOG4105CHU acetyl-coa acetyltransferase HPM96_17595 ENOG4108MHD transport protein HPM96_17605 ENOG4108K5P (LipO)protein HPM96_17610 ENOG4105C7W Xanthine dehydrogenase HPM96_17615 ENOG4108HR6 Dehydrogenase HPM96_17620 ENOG4108UTP (2Fe-2S)-binding domain protein HPM96_17625 ENOG4108JUB Transcriptional regulator HPM96_17630 ENOG4105IW6 Carbamoyltransferase HPM96_17635 ENOG4107RCH Diaminopropionate ammonia-lyase HPM96_17640 ENOG4107S4Y M20 DapE family protein YgeY HPM96_17650 ENOG4105C5B carbamate kinase HPM96_17655 ENOG4107P0T Selenium-dependent molybdenum hydroxylase system protein, YqeB family HPM96_17660 ENOG4105MJ6 selenium-dependent hydroxylase accessory protein YqeC HPM96_17665 ENOG4105MFX 4-diphosphocytidyl-2c-methyl-d-erythritol synthase HPM96_17670 ENOG4105BZ8 glutamate synthase HPM96_17675 ENOG4107UUR Chlorohydrolase aminohydrolase HPM96_17680 ENOG410873Y FAD binding domain in molybdopterin dehydrogenase HPM96_17685 ENOG4105C7W Xanthine dehydrogenase HPM96_17690 ENOG4105C2W permease HPM96_17695 ENOG4107QUY Guanine deaminase HPM96_17700 ENOG4105C7N Xanthine uracil vitamin C permease HPM96_17705 ENOG4108R8B oxidoreductase Fe-S subunit HPM96_17710 ENOG4105BZ8 glutamate synthase HPM96_17715 ENOG4105C2W permease HPM96_17730 ENOG4105CRK lysyL-tRNA synthetase HPM96_17740 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) HPM96_17745 ENOG4105T95 Thiol disulfide interChange protein HPM96_17750 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HPM96_17755 ENOG41071R3 Low-potential electron donor to a number of redox enzymes (By similarity) HPM96_17760 ENOG4108YDB Toxic component of a toxin-antitoxin (TA) module. Overexpression leads to growth arrest after 5 hours, with initial elongation of cells, followed by swelling. The toxic effects are abrogated by coexpression with antitoxin CptB. Interacts with cytoskeletal proteins FtsZ and MreB HPM96_17765 ENOG4105Y75 tpr repeat protein HPM96_17775 ENOG4108UT2 hemolysin iii HPM96_17780 ENOG4105N5Z UPF0267 protein HPM96_17785 ENOG4105CS2 ec 3.2.1.21 HPM96_17810 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family HPM96_17815 ENOG4105D0A hydroxylase HPM96_17820 ENOG4107RAQ aminopeptidase HPM96_17840 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase HPM96_17850 ENOG4108JQ1 Dehydrogenase HPM96_17865 ENOG4105D5P Methylmalonyl-coA mutase HPM96_17870 ENOG4105DJT lAO AO transport system ATPase HPM96_17875 ENOG4108M7F enoyl-CoA hydratase isomerase HPM96_17880 ENOG4105CYC Transferase HPM96_17885 ENOG4105DEQ transcriptional regulator HPM96_17890 ENOG4105MPN Membrane HPM96_17895 ENOG4108ZUB Lysine exporter protein (Lyse ygga) HPM96_17900 ENOG4105D64 Mechanosensitive ion channel HPM96_17905 ENOG4105D2N Aldolase HPM96_17940 ENOG4108JJB ABC transporter HPM96_17945 ENOG4107Z1W Fructose transport system kinase HPM96_17950 ENOG4108R4K DNA-binding, transcriptional regulator HPM96_17955 ENOG4108Q8A Fructose-1,6-bisphosphatase HPM96_17960 ENOG4105DXH Alcohol dehydrogenase zinc-binding domain protein HPM96_17965 ENOG4105CTS PTS system mannitol-specific HPM96_17970 ENOG4108X7Y Mannitol-specific cryptic phosphotransferase enzyme iia HPM96_17975 ENOG4105EPW hflc protein HPM96_17980 ENOG4105CV1 Transketolase (EC 2.2.1.1) HPM96_17985 ENOG4108K0D peptidase, M48 HPM96_18000 ENOG4105F3R pts system mannose fructose sorbose family iid HPM96_18005 ENOG4105ETZ PTS System HPM96_18010 ENOG4105DAS pts system HPM96_18035 ENOG4105DP5 Catalyzes the biosynthesis of agmatine from arginine (By similarity) HPM96_18055 ENOG4107QNK )-transporter HPM96_18065 ENOG4105RWS endonuclease I HPM96_18070 ENOG4105QF0 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) HPM96_18075 ENOG4105D7Z glutathione synthase HPM96_18090 ENOG4105CZX twitching motility protein HPM96_18095 ENOG4105DFA alanine racemase domain protein HPM96_18100 ENOG4108VIA integral membrane protein HPM96_18110 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) HPM96_18115 ENOG4105CSA Coproporphyrinogen iii oxidase HPM96_18120 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit HPM96_18125 ENOG41069H7 transport system small permease component HPM96_18130 ENOG4105CG6 trap dicarboxylate transporter dctm subunit HPM96_18135 ENOG4106MH3 alpha helix chain HPM96_18140 ENOG4105HDK L-asparaginase HPM96_18145 ENOG4105K33 Periplasmic Protein HPM96_18150 ENOG41090ED Protein with unknown function (DUF469) HPM96_18160 ENOG4105CEN a g-specific adenine glycosylase HPM96_18175 ENOG4105EAA nucleoside HPM96_18180 ENOG4105CXN decarboxylase HPM96_18185 ENOG4108UQV Membrane HPM96_18195 ENOG4105DFP Integrase HPM96_18240 ENOG4105DIJ Phosphoethanolamine transferase HPM96_18270 ENOG4105T40 surface antigen msp4 family protein HPM96_18285 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) HPM96_18300 ENOG4107SCJ type I restriction enzyme EcoKI subunit R HPM96_18340 ENOG4105CEU Arginine dihydrolase HPM96_18345 ENOG4105C5B carbamate kinase HPM96_18350 ENOG4105DBV ornithine carbamoyltransferase HPM96_18355 ENOG4105CSX c4-dicarboxylate anaerobic carrier HPM96_18360 ENOG4105XBY Regulates arginine biosynthesis genes (By similarity) HPM96_18380 ENOG4105D5K Hemolysin activator protein HPM96_18445 ENOG4105TS0 gtp-binding protein HPM96_18460 ENOG4106H6R UPF0380 protein HPM96_18465 ENOG4106549 Antirestriction protein HPM96_18470 ENOG4108YGG dna repair protein HPM96_18480 ENOG4105MAW Antitoxin component of a toxin-antitoxin (TA) module. Labile antitoxin that counteracts the effect of the CbtA (YeeV) toxin. It does not bind to the cognate toxin but instead binds to MreB and FtsZ (the toxin targets), enhancing their polymerization by forming higher-order bundles HPM96_18505 ENOG4105X54 addiction module antidote protein HPM96_18520 ENOG4105C2X Arabinose 5-phosphate isomerase HPM96_18525 ENOG4105ECX polysaccharide export HPM96_18530 ENOG4107V1M polysaccharide export protein HPM96_18535 ENOG4105CET Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity) HPM96_18540 ENOG4105E12 capsule polysaccharide HPM96_18545 ENOG41084CK capsule polysaccharide HPM96_18560 ENOG4108UW5 maltose o-acetyltransferase HPM96_18565 ENOG4105D5D udp-galactopyranose mutase HPM96_18570 ENOG4105K64 Glycosyl transferase, family 2 HPM96_18590 ENOG41090SZ ABC-2 type transporter HPM96_18595 ENOG4105U1E general secretion pathway protein M HPM96_18615 ENOG4105X5Z General secretion pathway protein I HPM96_18625 ENOG4108VAU general secretion pathway protein G HPM96_18630 ENOG4105D7Q type ii secretion system HPM96_18635 ENOG4107QHF type ii secretion system protein e HPM96_18650 ENOG410765S (LipO)protein HPM96_18660 ENOG4105F88 accessory colonization factor AcfD HPM96_18665 ENOG4105DAA L-lactate HPM96_18670 ENOG4107QP3 malate synthase g HPM96_18675 ENOG4108ZJF Glcg protein HPM96_18680 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) HPM96_18685 ENOG4105EU8 FAD linked oxidase domain protein HPM96_18690 ENOG4105CQB FAD linked oxidase domain protein HPM96_18695 ENOG4108KWP DNA-binding transcriptional regulator GlcC HPM96_18705 ENOG4107RCI amp-dependent synthetase and ligase HPM96_18715 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) HPM96_18720 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) HPM96_18730 ENOG4108M8S permease YjgP YjgQ family protein HPM96_18735 ENOG4108UUE Transcriptional regulator HPM96_18745 ENOG4108S55 polysaccharide biosynthesis protein HPM96_18750 ENOG4106FPV ATP-binding protein YghR HPM96_18755 ENOG4108NDC ATP-binding protein yghS HPM96_18760 ENOG4108GH0 ATP-binding protein yghT HPM96_18765 ENOG4105CJ3 phosphate transporter HPM96_18770 ENOG4106032 Glutathionylspermidine synthase HPM96_18775 ENOG4105CYM Glutathione S-transferase HPM96_18780 ENOG41082MF Hydrogenase assembly chaperone hypC hupF HPM96_18790 ENOG4108WGS hydrogenase 2-specific chaperone HPM96_18795 ENOG4108USZ hydrogenase HPM96_18800 ENOG4105DPX Hydrogenase, large subunit HPM96_18805 ENOG4105CJ5 hydrogenase 2 b cytochrome subunit HPM96_18810 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein HPM96_18815 ENOG4105E3S small subunit HPM96_18820 ENOG410900S Protein of unknown function (DUF2623) HPM96_18830 ENOG4105CPC Aldo Keto reductase HPM96_18840 ENOG4105CYX Short-chain dehydrogenase reductase Sdr HPM96_18845 ENOG4108ZZF transport protein (ExbD) HPM96_18850 ENOG4105CWK Biopolymer transport protein, ExbB HPM96_18855 ENOG4105C28 cystathionine HPM96_18860 ENOG4108K81 inner membrane protein YghB HPM96_18865 ENOG4105CF7 AraC family transcriptional regulator HPM96_18870 ENOG4108I6A alcohol dehydrogenase HPM96_18875 ENOG4105CV8 reductase HPM96_18880 ENOG4105ZKC Conserved Protein HPM96_18900 ENOG4105CCT upf0313 protein HPM96_18905 ENOG4107YCY Transcriptional regulator HPM96_18910 ENOG4105DEI Mannitol dehydrogenase HPM96_18915 ENOG4105CPQ Dehydrogenase HPM96_18920 ENOG4105DG4 malate L-lactate dehydrogenase HPM96_18925 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit HPM96_18935 ENOG4105CG6 trap dicarboxylate transporter dctm subunit HPM96_18940 ENOG4107TZ2 Cell division protein that is required for growth during stress conditions. May be involved in protecting or stabilizing the divisomal assembly under conditions of stress (By similarity) HPM96_18945 ENOG4107S7E 1-acyl-sn-glycerol-3-phosphate acyltransferase HPM96_18950 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HPM96_18955 ENOG4108J59 Extracellular solute-binding protein, family 5 HPM96_18960 ENOG4105F4I Transcriptional regulator HPM96_18965 ENOG4105H4F exported protein HPM96_18970 ENOG4105XJC Two component transcriptional regulator (Winged helix family HPM96_18975 ENOG4105DHQ Histidine kinase HPM96_18980 ENOG4105NF4 modulator of drug activity HPM96_18985 ENOG4105VRH Antibiotic biosynthesis monooxygenase HPM96_18990 ENOG4106KNT transcriptional regulator HPM96_19000 ENOG4105EHG Permease protein HPM96_19005 ENOG4105DQ5 transport system permease protein HPM96_19010 ENOG4105E0A ABC, transporter HPM96_19020 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HPM96_19025 ENOG4105IPS esterase HPM96_19030 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) HPM96_19035 ENOG4108SX3 cytoplasmic protein HPM96_19040 ENOG41087AY ADP-Ribose pyrophosphatase HPM96_19045 ENOG4105DFG type I secretion outer membrane protein HPM96_19055 ENOG4106032 Glutathionylspermidine synthase HPM96_19060 ENOG4108MR7 Arylsulfotransferase HPM96_19065 ENOG4108N92 Thiol disulfide Interchange Protein HPM96_19075 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b HPM96_19095 ENOG4105W0Z cytoplasmic protein HPM96_19105 ENOG4105PV3 Inner membrane protein yqiJ HPM96_19110 ENOG4107S78 Band 7 protein HPM96_19130 ENOG4105I7R Adenylate cyclase HPM96_19135 ENOG4106MWK domain protein HPM96_19150 ENOG4107ZVW dihydroneopterin aldolase HPM96_19160 ENOG4105EJC lysr family transcriptional regulator HPM96_19165 ENOG4106DSS Tartrate dehydratase subunit alpha HPM96_19170 ENOG4107GFK fumarate HPM96_19175 ENOG4107QPK )-transporter HPM96_19190 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) HPM96_19195 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HPM96_19210 ENOG4105Q26 Siderophore-interacting protein HPM96_19215 ENOG4105NTW Transcriptional regulator HPM96_19220 ENOG4107RHT methyl-accepting chemotaxis sensory transducer with Pas Pac sensor HPM96_19230 ENOG4108Y51 tRNA-binding protein HPM96_19235 ENOG4105CQ4 Transcriptional regulator HPM96_19240 ENOG4105CNT hydrolase family 2 HPM96_19245 ENOG4105FK9 beta-D-galactosidase beta subunit HPM96_19250 ENOG4105E5D amino acid HPM96_19255 ENOG4107W6W Conserved Protein HPM96_19260 ENOG4107WCA isomerase HPM96_19265 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HPM96_19275 ENOG4108VKG metal-dependent hydrolase HPM96_19280 ENOG4108UB4 uncharacterized protein ygjQ HPM96_19285 ENOG4105EE0 oxidoreductase HPM96_19290 ENOG4105DU1 integral membrane protein, terc HPM96_19295 ENOG4107QV7 Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system) (By similarity) HPM96_19300 ENOG4105P66 Membrane HPM96_19305 ENOG4105CTX dehydratase HPM96_19315 ENOG4105DPW Major facilitator superfamily MFS_1 HPM96_19340 ENOG4107YCY Transcriptional regulator HPM96_19345 ENOG4106W5V Membrane HPM96_19350 ENOG4105IYR Modulates the activity of the EnvZ OmpR two-component regulatory system, probably by directly modulating EnvZ enzymatic activity and increasing stability of phosphorylated OmpR (By similarity) HPM96_19355 ENOG4105WAY exported protein HPM96_19360 ENOG4105NE1 Conserved Protein HPM96_19365 ENOG41090KG Inner membrane protein YqjE HPM96_19370 ENOG4105YJD HPM96_19375 ENOG4108VBZ doxx family HPM96_19380 ENOG4105CHF Glutathione S-transferase HPM96_19385 ENOG4105KAF membrAne HPM96_19390 ENOG4105KAF membrAne HPM96_19395 ENOG4105CWB LysR family transcriptional Regulator HPM96_19400 ENOG4108CNN domain protein HPM96_19405 ENOG4106D80 Uncharacterized protein YhaL HPM96_19415 ENOG4105C44 Serine transporter HPM96_19420 ENOG4105EJQ L-serine dehydratase HPM96_19425 ENOG4105KME endoribonuclease L-psp HPM96_19430 ENOG4105C6N Formate acetyltransferase HPM96_19435 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) HPM96_19440 ENOG4108MST Involved in the import of threonine and serine into the cell, with the concomitant import of a proton (symport system) (By similarity) HPM96_19445 ENOG4105C7B Threonine dehydratase HPM96_19450 ENOG410811B TRANSCRIPTIONal HPM96_19475 ENOG4105BZW Glycerate kinase HPM96_19480 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase HPM96_19490 ENOG4105DJB Major Facilitator Superfamily HPM96_19495 ENOG4105CTX dehydratase HPM96_19500 ENOG4105ZEG Suppressor protein HPM96_19505 ENOG4108R8Z these effects are overcome by concomitant expression of antitoxin SohA (PrlF). Massive overexpression is toxic. Unlike most other characterized TA systems degrades rRNA, and co-folding of the proteins is necessary in vitro for inhibition of the RNase activity. It is not known if it has any sequence-specificity. Acts as a transcription factor. The YhaV PrlF complex binds the prlF-yhaV operon, probably negatively regulating its expression HPM96_19510 ENOG4105E98 transcriptional regulator DeoR family HPM96_19520 ENOG4108RG5 PTS system N-acetylgalactosamine-specific transporter subunit IIB HPM96_19530 ENOG4105F3R pts system mannose fructose sorbose family iid HPM96_19535 ENOG4108YTN IIa component HPM96_19540 ENOG4105CE4 GlcNAc 6-P deacetylase HPM96_19545 ENOG4105E70 isomerase HPM96_19555 ENOG4108UZY PTS System HPM96_19560 ENOG4105ETZ PTS System HPM96_19565 ENOG4105F3R pts system mannose fructose sorbose family iid HPM96_19570 ENOG4106HBN Galactosamine-6-phosphate isomerase HPM96_19575 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) HPM96_19595 ENOG4105W4M Transport-associated protein HPM96_19600 ENOG4107S21 permease HPM96_19605 ENOG4105K4T epimerase HPM96_19610 ENOG4107R7Y intracellular protease Pfpi family HPM96_19625 ENOG4108YYD acetyltransferase HPM96_19645 ENOG4105DEN Luciferase family HPM96_19650 ENOG4105CIC tryptophan-specific transport protein HPM96_19655 ENOG4105C1J atp-dependent rna helicase HPM96_19695 ENOG4105CHV Transcription elongation factor NusA HPM96_19715 ENOG4105DIJ Phosphoethanolamine transferase HPM96_19725 ENOG4105NTZ Preprotein translocase subunit SecG HPM96_19735 ENOG4105EEI dihydropteroate synthase HPM96_19740 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) HPM96_19750 ENOG4105HBR Rna-binding protein HPM96_19755 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) HPM96_19760 ENOG4106HRJ d-alanyl-d-alanine carboxypeptidase HPM96_19770 ENOG4105QYV Membrane HPM96_19785 ENOG4105EAH synthase HPM96_19790 ENOG4105HVQ Regulatory factor of maltose metabolism HPM96_19800 ENOG4105VFK BolA family HPM96_19805 ENOG4105UE2 Part of the ABC transporter complex MlaFEDB that actively prevents phospholipid accumulation at the cell surface. Probably maintains lipid asymmetry in the outer membrane by retrograde trafficking of phospholipids from the outer membrane to the inner membrane HPM96_19810 ENOG4105E3I toluene tolerance HPM96_19815 ENOG4107PE3 Mammalian cell entry related domain protein HPM96_19820 ENOG4105CY3 ABC transporter, permease HPM96_19825 ENOG4105DHJ ABC, transporter HPM96_19830 ENOG4105FEU K -dependent Na -Ca exchanger HPM96_19835 ENOG4105C2X Arabinose 5-phosphate isomerase HPM96_19845 ENOG4108P1K Required for the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane (By similarity) HPM96_19850 ENOG4105WI0 lipopolysaccharide transport periplasmic protein lptA HPM96_19855 ENOG4108IUZ ABC transporter HPM96_19860 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HPM96_19865 ENOG41080QH sigma 54 modulation protein ribosomal protein S30EA HPM96_19870 ENOG4107RM2 PTS IIA-like nitrogen-regulatory protein PtsN HPM96_19880 ENOG41080Z8 PHOSPHOCARRIER protein HPM96_19885 ENOG4108NIH transferase activity, transferring phosphorus-containing groups HPM96_19895 ENOG4108556 Isoprenoid biosynthesis protein with amidotransferase-like domain HPM96_19900 ENOG4105BZU Histidine kinase HPM96_19905 ENOG4105N5T Radical SAM Protein HPM96_19910 ENOG4105CBC glutamate synthase HPM96_19915 ENOG4105BZ8 glutamate synthase HPM96_19920 ENOG4105DFS Conserved Protein HPM96_19925 ENOG4108R66 Conserved Protein HPM96_19955 ENOG4105CEE C4-dicarboxylate transporter HPM96_19960 ENOG4105KB2 stringent starvation protein b HPM96_19965 ENOG4107MKT Stringent starvation protein a HPM96_19985 ENOG4105D6Z AFG1 family ATPase HPM96_19990 ENOG4108W2Q Cytochrome d ubiquinol oxidase subunit III HPM96_19995 ENOG4105C0H protease HPM96_20000 ENOG4105C0H protease HPM96_20015 ENOG4105RID UPF0379 protein yhcN HPM96_20020 ENOG4105UNR (Barnase) inhibitor HPM96_20035 ENOG4105ZQC membrane protein AaeX HPM96_20040 ENOG4105CR8 Transcriptional regulator HPM96_20045 ENOG4105D1U peptidase U62 modulator of DNA gyrase HPM96_20050 ENOG4105QD6 exported protein HPM96_20055 ENOG4105C03 ribonuclease HPM96_20065 ENOG4105VQ7 Rod shape-determining protein MreD HPM96_20070 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) HPM96_20080 ENOG41062P1 Diguanylate cyclase phosphodiesterase HPM96_20085 ENOG4105D3Z quinone oxidoreductase, yhdh yhfp family HPM96_20090 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein HPM96_20095 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase HPM96_20105 ENOG4107UEK pfkb domain protein HPM96_20110 ENOG4105CNN ABC, transporter HPM96_20115 ENOG4105C2J ABC transporter HPM96_20120 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator HPM96_20125 ENOG4105D2N Aldolase HPM96_20130 ENOG4105E98 transcriptional regulator DeoR family HPM96_20135 ENOG4107UEK pfkb domain protein HPM96_20140 ENOG4105RG0 Membrane HPM96_20145 ENOG4108IA2 Sodium pantothenate symporter HPM96_20155 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) HPM96_20165 ENOG4105CEC DNA methylase N-4 N-6 HPM96_20170 ENOG41061ME transport protein HPM96_20175 ENOG4108XG4 DNA-binding transcriptional regulator HPM96_20180 ENOG4105C1P efflux transporter, rnd family, mfp subunit HPM96_20185 ENOG4105BZS acriflavin resistance protein HPM96_20190 ENOG4105XCM membrane LIPOPROTEIN HPM96_20200 ENOG4105EZ7 amino acid ABC transporter HPM96_20205 ENOG4105DRP amino acid AbC transporter HPM96_20210 ENOG4105CDA abc transporter atp-binding protein HPM96_20250 ENOG4108Z0R Transferase HPM96_20255 ENOG4105SG3 Protein of unknown function (DUF1488) HPM96_20270 ENOG4108WI1 Dna topoisomerase HPM96_20280 ENOG4105C79 DNA protecting protein DprA HPM96_20300 ENOG4105C1A potassium transporter peripheral membrane HPM96_20310 ENOG4105VCN Rescues the ribosomes stalled at the 3' end of non-stop mRNAs. May induce hydrolysis of the ribosome-bound peptidyl-tRNA. This activity is crucial when the stalled ribosome can not be rescued by the SsrA(tmRNA)-SmpB quality control system HPM96_20315 ENOG4105W1Y Transcriptional regulator HPM96_20320 ENOG4105VTS DnaJ-like, subfamily C HPM96_20350 ENOG41067V7 50S ribosomal protein L36 HPM96_20355 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) HPM96_20400 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) HPM96_20445 ENOG41080KG One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) HPM96_20470 ENOG4108UQY Iron-storage protein HPM96_20475 ENOG4105W53 bacterioferritin-associated ferredoxin HPM96_20505 ENOG4108ZKU Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions (By similarity) HPM96_20515 ENOG4105WWK YheO domain protein HPM96_20520 ENOG4108V1T peptidylprolyl cis-trans isomerase HPM96_20530 ENOG4108YZY peptidylprolyl cis-trans isomerase HPM96_20535 ENOG4105VKU nucleicacid-binding protein HPM96_20550 ENOG4105C5H ABC transporter HPM96_20555 ENOG4105DNZ Alpha Beta Hydrolase HPM96_20565 ENOG4105CJE phosphoribulokinase (EC 2.7.1.19) HPM96_20570 ENOG4108UKZ OsmC family HPM96_20580 ENOG410613R integral membrane protein, YccS YhfK family HPM96_20585 ENOG4105C8Y Acetylornithine aminotransferase HPM96_20590 ENOG4105DDQ anthranilate synthase HPM96_20595 ENOG4105MZU cell filamentation protein HPM96_20605 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) HPM96_20615 ENOG4107QZF nitrite reductase NADPH large subunit HPM96_20620 ENOG4105WZK nitrite reductase NADPH small subunit HPM96_20625 ENOG4107V9H nitrite transporter HPM96_20635 ENOG4105VYH HPM96_20640 ENOG4106PKC pyridoxal phosphate binding HPM96_20645 ENOG4106M0N transport system permease protein HPM96_20650 ENOG4105MUZ Protein of unknown function DUF2620 HPM96_20655 ENOG41080QX K07048 phosphotriesterase-related protein HPM96_20660 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) HPM96_20665 ENOG4108626 Racemase HPM96_20670 ENOG4105RMW regulation of transcription, DNA-dependent HPM96_20675 ENOG4108M21 HPM96_20680 ENOG4105C31 Tryptophanyl-tRNA synthetase HPM96_20685 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) HPM96_20690 ENOG4105DJV ribulose-phosphate 3-epimerase HPM96_20695 ENOG4105DFE Dna adenine methylase HPM96_20700 ENOG4105EGB membrane protein DamX HPM96_20715 ENOG4105E4G Type IV pilus HPM96_20720 ENOG4105ITY Required for the use of extracellular DNA as a nutrient HPM96_20725 ENOG4105XPX DNA utilization protein HofO HPM96_20730 ENOG41065NF Fimbrial assembly family protein HPM96_20735 ENOG4108U1Q Pilus assembly protein HPM96_20740 ENOG4108JQC penicillin-binding protein 1A HPM96_20745 ENOG4107RK2 ADP-ribose diphosphatase NudE HPM96_20750 ENOG4105DQY intracellular growth attenuator HPM96_20755 ENOG4107Y3D HAD-superfamily hydrolase subfamily IA variant 3 HPM96_20760 ENOG4105VEJ Heat shock protein HPM96_20770 ENOG4108MAJ Membrane HPM96_20790 ENOG4105E0F Histidine kinase HPM96_20800 ENOG4108RRZ Transcription elongation factor GreB HPM96_20805 ENOG4105BZM domain protein HPM96_20810 ENOG4105XFK Ferrous iron transport protein A HPM96_20815 ENOG4105CE1 Ferrous iron transport protein b HPM96_20825 ENOG4105DNE Transposase HPM96_20835 ENOG4105MJ2 Competence protein HPM96_20845 ENOG4105C6Z Gluconate HPM96_20850 ENOG4107RTM 4-alpha-glucanotransferase (EC 2.4.1.25) HPM96_20855 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) HPM96_20870 ENOG4105E0Y RtcB Protein HPM96_20875 ENOG4105CYB regulatoR HPM96_20880 ENOG4105E98 transcriptional regulator DeoR family HPM96_20895 ENOG4105C6V Glycerol-3-phosphate dehydrogenase HPM96_20915 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) HPM96_20935 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) HPM96_20940 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) HPM96_20945 ENOG41076UM multiple antibiotic resistance (MarC)-related protein HPM96_20955 ENOG4105C9U ATP-dependent DNA helicase RecQ HPM96_20960 ENOG4105C6Z Gluconate HPM96_20965 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family HPM96_20970 ENOG4105DIQ Transcriptional regulator HPM96_20975 ENOG4105C2I pirin domain protein HPM96_20980 ENOG4105D9R oxidoreductase HPM96_20985 ENOG4105WCN acetyltransferase HPM96_20990 ENOG4105GMB type VI secretion system effector, hcp1 family HPM96_21010 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) HPM96_21015 ENOG4105WC8 Conserved Protein HPM96_21020 ENOG4107T6V glycerophosphoryl diester phosphodiesterase HPM96_21025 ENOG4108IJ9 (ABC) transporter HPM96_21030 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component HPM96_21035 ENOG4105E4X binding-protein-dependent transport systems inner membrane Component HPM96_21040 ENOG4105BZ7 extracellular solute-binding protein family 1 HPM96_21045 ENOG4108IV0 ABC, transporter HPM96_21050 ENOG4105C0Z ABC transporter HPM96_21055 ENOG4105CF8 branched-chain amino acid ABC transporter, permease HPM96_21060 ENOG4105C32 Amino acid ABC transporter (Permease) HPM96_21065 ENOG4105CP9 extracellular ligand-binding receptor HPM96_21070 ENOG4105U59 -acetyltransferase HPM96_21075 ENOG4105CP9 extracellular ligand-binding receptor HPM96_21080 ENOG4105DEK Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HPM96_21085 ENOG4105CRP Part of the ABC transporter FtsEX involved in HPM96_21090 ENOG4105CAK Cell division ATP-binding protein ftsE HPM96_21095 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) HPM96_21100 ENOG4106H78 methyltransferase HPM96_21105 ENOG4105MG3 Membrane HPM96_21115 ENOG4107FS9 Membrane HPM96_21135 ENOG4105EX9 Membrane HPM96_21140 ENOG4108W1V Lipoprotein HPM96_21145 ENOG4105F9N Major Facilitator Superfamily HPM96_21150 ENOG4105DSF transport protein HPM96_21155 ENOG4107YAK holo-(acyl carrier protein) synthase 2 HPM96_21160 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein HPM96_21165 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HPM96_21170 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HPM96_21175 ENOG4106665 Part of the ABC transporter complex NikABCDE involved in nickel import. Responsible for energy coupling to the transport system (By similarity) HPM96_21180 ENOG4105EFJ Part of the ABC transporter complex NikABCDE involved in nickel import. Responsible for energy coupling to the transport system (By similarity) HPM96_21200 ENOG4105CMI transporter HPM96_21205 ENOG4105CJ1 ABC, transporter HPM96_21210 ENOG4105D0S secretion protein (HlyD HPM96_21225 ENOG4107UNS conserved inner membrane protein HPM96_21230 ENOG4105CBX hi0933 family HPM96_21235 ENOG4105CJ3 phosphate transporter HPM96_21250 ENOG4105DUX Transporter HPM96_21260 ENOG4105DGW oligopeptidase A HPM96_21265 ENOG4105D6S protein involved in catabolism of external DNA HPM96_21270 ENOG4105DC8 reductase HPM96_21280 ENOG4105KBH arsR family transcriptional regulator HPM96_21285 ENOG4107R5R arsenical pump membrane protein HPM96_21290 ENOG4105K89 arsenate reductase HPM96_21310 ENOG4105Y4Z Outer Membrane Lipoprotein HPM96_21320 ENOG4106QJH hemin transport protein HPM96_21325 ENOG4107ENK receptor HPM96_21335 ENOG4105D4P Coproporphyrinogen iii oxidase HPM96_21340 ENOG41090JE Utilization Protein HPM96_21350 ENOG4105EHG Permease protein HPM96_21355 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) HPM96_21360 ENOG4105KT7 mgtC SapB transporter HPM96_21365 ENOG4105XXV Acid-resistance protein HPM96_21370 ENOG41060V2 Acid-resistance protein HPM96_21375 ENOG4108YK4 Acid-resistance membrane protein HPM96_21380 ENOG4106WJ0 Regulates the expression of several genes involved in acid resistance. Required for the expression of gadA and gadBC, among others, regardless of media or growth conditions. Binds directly to the 20 bp GAD box found in the control regions of both loci HPM96_21390 ENOG4105C1P efflux transporter, rnd family, mfp subunit HPM96_21395 ENOG4105BZS acriflavin resistance protein HPM96_21410 ENOG4105CVK Glutamate decarboxylase HPM96_21415 ENOG4105CA0 peroxidase HPM96_21425 ENOG4106S2D Transcriptional regulator HPM96_21430 ENOG4105CBN LysR family transcriptional regulator HPM96_21435 ENOG4107H3J ribonuclease HPM96_21440 ENOG4105CSH Transporter HPM96_21445 ENOG41066T0 asmA family HPM96_21450 ENOG4105CMB EAL domain-containing protein HPM96_21455 ENOG4107SS6 2-dehydro-3-deoxygluconokinase HPM96_21460 ENOG4105CS0 peptidase HPM96_21470 ENOG4105BZU Histidine kinase HPM96_21475 ENOG4105EJG cellulose synthase HPM96_21480 ENOG4105K2Z endo-1,4-d-glucanase (EC 3.2.1.4) HPM96_21485 ENOG4107EEX Cellulose synthase regulator protein HPM96_21490 ENOG4107QZ7 Cellulose synthase catalytic subunit HPM96_21500 ENOG410661M cytoplasmic protein HPM96_21505 ENOG4105U74 cellulose biosynthesis protein BcsE HPM96_21510 ENOG4105WQA Cellulose biosynthesis protein BcsF HPM96_21515 ENOG4105D1V cellulose synthase operon protein YhjU HPM96_21540 ENOG4105C44 Serine transporter HPM96_21545 ENOG4108JQ7 (ABC) transporter HPM96_21550 ENOG4105C3U ABC transporter HPM96_21555 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HPM96_21560 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HPM96_21565 ENOG4105DEF Extracellular solute-binding protein, family 5 HPM96_21575 ENOG4105DIJ Phosphoethanolamine transferase HPM96_21580 ENOG4105FCD Major Facilitator HPM96_21585 ENOG4105EAX Putative lipase HPM96_21590 ENOG4108R3E Dna-3-methyladenine glycosylase i HPM96_21595 ENOG4105HNP -acetyltransferase HPM96_21600 ENOG4107QY8 reductase HPM96_21605 ENOG4108ZG0 Ompa motb domain protein HPM96_21615 ENOG4106JH6 (LipO)protein HPM96_21620 ENOG4105MVF Transcriptional regulator HPM96_21630 ENOG41060TC Hok gef cell toxic protein HPM96_21655 ENOG4105MEV Acyl-transferase HPM96_21660 ENOG4108Z12 YiaAB two helix domain-containing protein HPM96_21665 ENOG410688U Inner membrane protein yiaB HPM96_21670 ENOG4105CMG Carbohydrate kinase HPM96_21680 ENOG4105DFW ABC transporter HPM96_21685 ENOG4105C2J ABC transporter HPM96_21690 ENOG4108HWW ABC transporter HPM96_21695 ENOG4105T16 Transcriptional regulator (AraC family) HPM96_21700 ENOG4108UR8 BAX protein HPM96_21705 ENOG4107T9C Alpha amylase catalytic region HPM96_21710 ENOG4105JKW Valine--pyruvate aminotransferase HPM96_21715 ENOG4108XIB electron transport protein ysaA HPM96_21720 ENOG4105J4Q Transcriptional regulator HPM96_21730 ENOG4108R66 Conserved Protein HPM96_21735 ENOG4105XDZ Tripartite ATP-independent periplasmic transporter HPM96_21740 ENOG4105CG6 trap dicarboxylate transporter dctm subunit HPM96_21745 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit HPM96_21750 ENOG4105CMG Carbohydrate kinase HPM96_21755 ENOG4105H6Q decarboxylase HPM96_21760 ENOG41064BZ L-xylulose 5-phosphate 3-epimerase HPM96_21765 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase HPM96_21775 ENOG4105CT4 transporter HPM96_21785 ENOG4105PF0 Antitoxin component of a toxin-antitoxin (TA) module. Functions as an mRNA interferase antitoxin HPM96_21800 ENOG4105C26 Dehydrogenase HPM96_21810 ENOG4105C0A alcohol dehydrogenase HPM96_21815 ENOG4105EM7 Selenocysteine-specific translation elongation factor HPM96_21825 ENOG4108U78 Glutathione S-transferase HPM96_21830 ENOG4108BMY protease HPM96_21875 ENOG4105EFX secretion protein, HlyD family HPM96_21880 ENOG4105FP6 Protein of unknown function (DUF3302) HPM96_21885 ENOG4105CTS PTS system mannitol-specific HPM96_21895 ENOG4105E61 Mannitol repressor protein HPM96_21900 ENOG41060ND LF82 chromosome, complete sequence HPM96_21905 ENOG4108YYI Protein of unknown function (DUF2810) HPM96_21910 ENOG4108WY4 inner membrane lipoprotein HPM96_21920 ENOG4105DAA L-lactate HPM96_21925 ENOG41073TP transcriptional regulator HPM96_21935 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) HPM96_21940 ENOG4105D7W serine acetyltransferase HPM96_21955 ENOG4105VW4 glutaredoxin 3 HPM96_21960 ENOG4107YZP Rhodanese domain protein HPM96_21970 ENOG41063SB peptidase HPM96_21975 ENOG4105PXI polysaccharide deacetylase HPM96_21980 ENOG4105K64 Glycosyl transferase, family 2 HPM96_21990 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) HPM96_22000 ENOG4105XA0 heptosyltransferase ii HPM96_22005 ENOG4105D16 lipopolysaccharide heptosyltransferase i HPM96_22010 ENOG41068PG O-Antigen polymerase HPM96_22015 ENOG4105K64 Glycosyl transferase, family 2 HPM96_22020 ENOG4105X1N Glycosyl transferase family 8 HPM96_22030 ENOG4105X1N Glycosyl transferase family 8 HPM96_22035 ENOG4106AH0 Glycosyl Transferase HPM96_22040 ENOG4107543 (lipo)polysaccharide HPM96_22045 ENOG4107RJ7 Glycosyl transferase (Group 1 HPM96_22050 ENOG4105DKP glycosyl transferase, family 9 HPM96_22055 ENOG4105D8A 3-Deoxy-D-manno-octulosonic-acid transferase HPM96_22075 ENOG4105KDC 50s ribosomal protein l28 HPM96_22085 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase HPM96_22090 ENOG4108Z1K This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) HPM96_22110 ENOG4105DSJ YicC domain protein HPM96_22115 ENOG4105F5P DNA-damage-inducible protein d HPM96_22120 ENOG4105EN6 Membrane HPM96_22130 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) HPM96_22140 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) HPM96_22145 ENOG4105FE8 tRNA (Guanosine-2'-O-)-methyltransferase HPM96_22150 ENOG4105CB5 ATP-dependent DNA helicase recG HPM96_22155 ENOG4105D6U Sodium Glutamate Symporter HPM96_22160 ENOG4105C2W permease HPM96_22165 ENOG4105JV1 AsmA family HPM96_22175 ENOG4105DKQ ROK family HPM96_22185 ENOG4105D2N Aldolase HPM96_22190 ENOG4105DM4 PTS System HPM96_22195 ENOG4108YRF PTS System HPM96_22200 ENOG4105DM4 PTS System HPM96_22205 ENOG4105ETD TRANSCRIPTIONal HPM96_22210 ENOG4105CJQ hydrolase, family 31 HPM96_22215 ENOG4105CT4 transporter HPM96_22230 ENOG4105S8Q sugar efflux transporter HPM96_22235 ENOG4108UZ3 Transporter HPM96_22240 ENOG4105D01 (LipO)protein HPM96_22245 ENOG4105T8A Uncharacterized protein YicS HPM96_22270 ENOG4105IBT Required for translocation of effector proteins via the type III secretion system SPI-1, which is essential for an efficient bacterial internalization. Probably acts by modulating the secretion of SipA, SipB, and SipC HPM96_22275 ENOG4108YAB Invasion protein HPM96_22280 ENOG4105TNG K13735 adhesin invasin HPM96_22300 ENOG4108SAJ Protein of unknown function (DUF1198) HPM96_22305 ENOG4105C7N Xanthine uracil vitamin C permease HPM96_22315 ENOG4105CXY transporter HPM96_22320 ENOG4105CXY transporter HPM96_22325 ENOG4105BZU Histidine kinase HPM96_22330 ENOG4108KX4 response regulator HPM96_22345 ENOG4105M71 acetolactate synthase 1 regulatory subunit HPM96_22350 ENOG4105C7K acetolactate synthase HPM96_22365 ENOG4105E5M Multidrug resistance protein D HPM96_22370 ENOG4105J13 transcriptional regulator HPM96_22375 ENOG4105JP4 Inner membrane protein yidG HPM96_22380 ENOG4105VG5 Membrane HPM96_22385 ENOG4105CBG Sulfatase HPM96_22390 ENOG4107RUZ Sss sodium solute transporter superfamily HPM96_22395 ENOG4108AHD Transcriptional regulator HPM96_22400 ENOG4105F8D glycoside hydrolase family 4 HPM96_22405 ENOG4105CI1 PTS System HPM96_22410 ENOG4105FDP GntR family transcriptional regulator HPM96_22430 ENOG4105R2A (LipO)protein HPM96_22435 ENOG4105D99 atp gtp-binding protein HPM96_22445 ENOG4105DJB Major Facilitator Superfamily HPM96_22455 ENOG4108RTU Aldolase HPM96_22460 ENOG4105EI3 2-dehydro-3-deoxygalactonokinase EC 2.7.1.58 HPM96_22465 ENOG4105EMF GntR family transcriptional regulator HPM96_22470 ENOG410657R replicase EC 2.7 HPM96_22475 ENOG410667J hydrolase HPM96_22480 ENOG4105VP5 Bacterial protein of unknown function (DUF937) HPM96_22485 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HPM96_22495 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) HPM96_22510 ENOG4105VG0 50S ribosomal protein l34 HPM96_22545 ENOG4108P6C Tryptophan transporter of low affinity HPM96_22555 ENOG4105G2Y Transcriptional regulator HPM96_22560 ENOG4105E8Q phosphopantetheinyl transferase HPM96_22565 ENOG4108YYH Nadph-dependent fmn reductase HPM96_22570 ENOG4105C7N Xanthine uracil vitamin C permease HPM96_22575 ENOG4107UB3 HAD-superfamily hydrolase subfamily IA variant 3 HPM96_22605 ENOG4108UTW Plays a role in the regulation of phosphate uptake HPM96_22610 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) HPM96_22615 ENOG4105E2Z phosphate ABC transporter (Permease HPM96_22620 ENOG4105C8U phosphate abc transporter HPM96_22625 ENOG4107QMV Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity) HPM96_22635 ENOG4105CW0 outer membrane usher protein HPM96_22645 ENOG4108RQP Major type 1 subunit fimbrin HPM96_22650 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) HPM96_22700 ENOG4105GXX Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit I associates with the membrane and may be involved with cation translocation HPM96_22715 ENOG4105QTB Flavodoxin HPM96_22720 ENOG4108VVK transcriptional Regulator, AsnC HPM96_22750 ENOG4105C2J ABC transporter HPM96_22755 ENOG4105CNN ABC, transporter HPM96_22760 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator HPM96_22765 ENOG4108RVA ribokinase HPM96_22770 ENOG4105ETE Transcriptional regulator (LacI family HPM96_22775 ENOG4105C0R drug resistance transporter emrb qaca subfamily HPM96_22780 ENOG4107EJG GntR family transcriptional regulator HPM96_22820 ENOG4108WFC UPF0438 protein yifE HPM96_22825 ENOG4105C0P Mg chelatase subunit ChlI HPM96_22845 ENOG4105P3Y Acetolactate synthase 2 regulatory subunit HPM96_22850 ENOG4105CM2 brancheD-chain amino acid aminotransferase HPM96_22860 ENOG4105C7B Threonine dehydratase HPM96_22865 ENOG4105EMY transcriptional regulator HPM96_22875 ENOG4105KQ5 peptidylprolyl cis-trans isomerase HPM96_22885 ENOG4105C4R Atp-dependent dna helicase HPM96_22910 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) HPM96_22915 ENOG4105ESV Glycosyl transferase, family 4 HPM96_22920 ENOG4105SFE lipopolysaccharide biosynthesis protein HPM96_22925 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase HPM96_22930 ENOG4107QQG Dehydrogenase HPM96_22935 ENOG4105C1B dTDP-glucose 4-6-dehydratase HPM96_22940 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) HPM96_22945 ENOG4108WJ1 acetyltransferase HPM96_22950 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase HPM96_22955 ENOG4105EGZ biosynthesis protein HPM96_22975 ENOG4105C85 amino acid HPM96_23000 ENOG4105C4X radical SAM domain protein HPM96_23005 ENOG4105ENH Sulfatase HPM96_23010 ENOG410601J HemY protein HPM96_23015 ENOG4105ECF c-methyltransferase HPM96_23020 ENOG41076E6 Uroporphyrinogen-III Synthase HPM96_23030 ENOG4107T0K Adenylate cyclase HPM96_23050 ENOG4105S7Z (LipO)protein HPM96_23060 ENOG4105CT0 Protein of unknown function, DUF484 HPM96_23070 ENOG4105DFC had-superfamily hydrolase, subfamily ia, variant HPM96_23075 ENOG4105C4R Atp-dependent dna helicase HPM96_23080 ENOG4107V4F S-adenosyl-l-methionine hydroxide adenosyltransferase HPM96_23085 ENOG4108T58 Mg2 transport protein CorA HPM96_23090 ENOG4107QUT magnesium and cobalt transport protein CorA HPM96_23105 ENOG4105FR1 rard protein HPM96_23110 ENOG4108VUY thioesterase Superfamily protein HPM96_23115 ENOG4105HDD phospholipase HPM96_23120 ENOG4105C9U ATP-dependent DNA helicase RecQ HPM96_23125 ENOG4105CCF Lysine exporter protein (Lyse ygga) HPM96_23130 ENOG410829K Lysine exporter protein (Lyse ygga) HPM96_23135 ENOG4108EUD Lysophospholipase HPM96_23140 ENOG4105DQF Hydrolase HPM96_23145 ENOG4105EMK carboxylate amino acid amine transporter HPM96_23150 ENOG4105DZ2 Transcriptional regulator HPM96_23160 ENOG4105F52 Transcriptional regulator HPM96_23165 ENOG4105DQW permease for cytosine purines, uracil, thiamine, allantoin HPM96_23175 ENOG4105C5B carbamate kinase HPM96_23180 ENOG4107REC cytoplasmic protein HPM96_23185 ENOG4107R1Q Membrane protein FdrA HPM96_23195 ENOG4106XMA In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2 (By similarity) HPM96_23200 ENOG4105CDZ Carboxymethylenebutenolidase (EC 3.1.1.45) HPM96_23205 ENOG4108I5U Uridine phosphorylase HPM96_23220 ENOG4105JN3 extra-cytoplasmic solute receptor family protein HPM96_23225 ENOG4108RTU Aldolase HPM96_23230 ENOG4105EI3 2-dehydro-3-deoxygalactonokinase EC 2.7.1.58 HPM96_23235 ENOG4107HP6 Transcriptional regulator HPM96_23240 ENOG4105CGY Dna recombination protein HPM96_23250 ENOG4105JC1 sterol-binding domain protein HPM96_23260 ENOG4105WKS Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) HPM96_23265 ENOG4105X8U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity) HPM96_23270 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) HPM96_23280 ENOG4105MDZ Transcriptional activator rfaH HPM96_23285 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) HPM96_23290 ENOG4108EX3 reductase HPM96_23310 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein HPM96_23315 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) HPM96_23320 ENOG4108RR8 protoporphyrinogen oxidase HPM96_23350 ENOG4105FNP Molybdopterin-guanine dinucleotide biosynthesis protein b HPM96_23355 ENOG4105C6R Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) HPM96_23360 ENOG4105PC1 Conserved Protein HPM96_23365 ENOG4105E27 serine threonine protein kinase HPM96_23370 ENOG4108Z33 Thiol disulfide Interchange Protein HPM96_23380 ENOG4106HNH Acyl-transferase HPM96_23385 ENOG4105C2M dna polymerase I HPM96_23400 ENOG4105D4P Coproporphyrinogen iii oxidase HPM96_23405 ENOG4106FIY HPM96_23410 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family HPM96_23415 ENOG4105CUX Signal transduction histidine kinase HPM96_23420 ENOG4105C5F glutamine synthetase HPM96_23425 ENOG4105CI3 gtp-binding protein typa HPM96_23430 ENOG4105VNT transposase (IS4 family) protein HPM96_23435 ENOG4108K85 Transcriptional regulator HPM96_23440 ENOG4108KHF Resistance protein HPM96_23445 ENOG4105R9B Major Facilitator HPM96_23450 ENOG4108KUC Outer membrane channel protein that allows an efficient diffusion of low-molecular-weight solutes such as small sugars and tetraglycine. However, the specific substrate recognized by the OmpL channel is HPM96_23455 ENOG4105CT4 transporter HPM96_23460 ENOG4105CT4 transporter HPM96_23465 ENOG4105CJQ hydrolase, family 31 HPM96_23470 ENOG4107WI4 Aldose-1-epimerase HPM96_23475 ENOG4107QKS N-acylglucosamine 2-epimerase HPM96_23480 ENOG4105D2M Aldolase HPM96_23485 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase HPM96_23490 ENOG4108MGF sugar kinase HPM96_23495 ENOG4105E98 transcriptional regulator DeoR family HPM96_23500 ENOG4105EJU HAD-superfamily hydrolase subfamily IA variant 3 HPM96_23515 ENOG4105SUU thioesterase domain HPM96_23530 ENOG41068KX affects formate dehydrogenase-N HPM96_23545 ENOG4108MG3 formate dehydrogenase HPM96_23550 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein HPM96_23565 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) HPM96_23575 ENOG4108V87 frv operon regulatory protein HPM96_23580 ENOG4106C3V frv operon regulatory protein HPM96_23585 ENOG4105CN9 Peptidase m42 family protein HPM96_23590 ENOG4105DM4 PTS System HPM96_23595 ENOG41064BA PTS system, fructose-specific, IIA component HPM96_23620 ENOG4105DKG l-rhamnose isomerase HPM96_23635 ENOG4108BRW Activates expression of the rhaSR operon in response to L-rhamnose (By similarity) HPM96_23645 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) HPM96_23655 ENOG4108RPX mosc domain containing protein HPM96_23660 ENOG4105E0F Histidine kinase HPM96_23665 ENOG4105E3W Two component transcriptional regulator (Winged helix family HPM96_23670 ENOG4105FMW periplasmic HPM96_23685 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein HPM96_23700 ENOG4105EBK exported protein HPM96_23705 ENOG4108VTS Membrane HPM96_23710 ENOG41065TG regulatoR HPM96_23720 ENOG4105DP0 ferredoxin-NADP reductase HPM96_23725 ENOG4105CBT Fructose-1,6-bisphosphatase HPM96_23735 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) HPM96_23760 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase HPM96_23775 ENOG41063M6 Cell Division Protein HPM96_23780 ENOG4105ETE Transcriptional regulator (LacI family HPM96_23785 ENOG4105C25 Primosomal protein n' HPM96_23795 ENOG4107S01 Repressor protein MetJ HPM96_23805 ENOG4105C28 cystathionine HPM96_23810 ENOG4105CFH Aspartokinase HPM96_23815 ENOG4105DRB nucleoside-specific channel-forming protein HPM96_23820 ENOG4105CGH 5'-nucleotidase HPM96_23825 ENOG4105CGH 5'-nucleotidase HPM96_23835 ENOG4105CGH 5'-nucleotidase HPM96_23840 ENOG4105SYT Methylenetetrahydrofolate reductase HPM96_23850 ENOG4108Q5Y Membrane HPM96_23855 ENOG4108XC3 NADH ubiquinone oxidoreductase HPM96_23860 ENOG4105DCT glycerol dehydrogenase HPM96_23865 ENOG4107T9Z Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) HPM96_23870 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) HPM96_23875 ENOG4105DM4 PTS System HPM96_23880 ENOG4108YRF PTS System HPM96_23890 ENOG4108AHH pyruvate formate lyase II activase HPM96_23895 ENOG4108XCZ PTS System HPM96_23900 ENOG4106R3P AraC family transcriptional regulator HPM96_23905 ENOG4105DIJ Phosphoethanolamine transferase HPM96_23920 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase HPM96_23930 ENOG4105CH7 arginosuccinase HPM96_23935 ENOG4105CXK mandelate racemase muconate lactonizing HPM96_23940 ENOG4108I5G Major Facilitator superfamily HPM96_23945 ENOG4105C5Q Transcriptional regulator HPM96_23955 ENOG4105EJ2 Transcriptional regulator HPM96_23960 ENOG4108Y73 Membrane HPM96_23970 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) HPM96_23975 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) HPM96_24005 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase HPM96_24040 ENOG4105PM1 preprotein translocase subunit SecE HPM96_24045 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) HPM96_24080 ENOG4108RVA ribokinase HPM96_24100 ENOG4105D41 biosynthesis protein thiH HPM96_24110 ENOG4105WHD thiamine biosynthesis protein ThiS HPM96_24115 ENOG4105D06 uba thif-type nad fad binding protein HPM96_24150 ENOG4105R2J Conserved Protein HPM96_24160 ENOG4108T8B Protein of unknown function (DUF1481) HPM96_24165 ENOG4105JBU Binds zinc. Could be an important component of the zinc- balancing mechanism HPM96_24170 ENOG4105BZU Histidine kinase HPM96_24175 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family HPM96_24180 ENOG4105C12 Phosphoribosylglycinamide synthetase