locus-tag	class	description
HPM96_00005	COG0456	acetyltransferase
HPM96_00015	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
HPM96_00020	COG2224	Isocitrate lyase
HPM96_00030	COG1414	Transcriptional regulator
HPM96_00040	COG1283	sodium-dependent phosphate transmembrane transporter activity
HPM96_00050	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HPM96_00090	COG1187	pseudouridine synthase activity
HPM96_00105	COG3541	Predicted nucleotidyltransferase
HPM96_00120	COG5301	cellulose 1,4-beta-cellobiosidase activity
HPM96_00200	COG0741	lytic transglycosylase activity
HPM96_00215	COG0527	aspartate kinase activity
HPM96_00240	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HPM96_00255	COG3833	ABC-type maltose transport systems, permease component
HPM96_00260	COG1175	transmembrane transport
HPM96_00265	COG2182	Extracellular solute-binding protein
HPM96_00270	COG3842	ATPase activity
HPM96_00285	COG1357	PFAM Pentapeptide repeats (8 copies)
HPM96_00305	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HPM96_00315	COG0534	Mate efflux family protein
HPM96_00320	COG3237	CsbD-like
HPM96_00325	COG0735	belongs to the Fur family
HPM96_00335	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HPM96_00345	COG0604	alcohol dehydrogenase
HPM96_00350	COG0305	Participates in initiation and elongation during chromosome replication
HPM96_00355	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HPM96_00360	COG1448	Aminotransferase
HPM96_00370	COG3700	Belongs to the class B bacterial acid phosphatase family
HPM96_00375	COG0432	Pfam Uncharacterised protein family UPF0047
HPM96_00380	COG2315	Protein conserved in bacteria
HPM96_00385	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HPM96_00390	COG0629	single-stranded DNA binding
HPM96_00400	COG4943	cyclic-guanylate-specific phosphodiesterase activity
HPM96_00405	COG2207	Transcriptional regulator
HPM96_00410	COG0789	Transcriptional regulator
HPM96_00415	COG2252	PERMEase
HPM96_00420	COG0025	NhaP-type Na H and K H
HPM96_00430	COG3162	membrane
HPM96_00435	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HPM96_00445	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
HPM96_00450	COG0437	4 iron, 4 sulfur cluster binding
HPM96_00455	COG3301	Polysulphide reductase, NrfD
HPM96_00460	COG1138	Cytochrome C-type biogenesis protein
HPM96_00465	COG3088	subunit of a heme lyase
HPM96_00470	COG4235	cytochrome complex assembly
HPM96_00475	COG1301	dicarboxylic acid transport
HPM96_00480	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
HPM96_00495	COG1289	transmembrane transporter activity
HPM96_00500	COG1566	PFAM secretion protein HlyD family protein
HPM96_00510	COG2015	COG2015, Alkyl sulfatase and related hydrolases
HPM96_00515	COG1940	carbohydrate kinase activity
HPM96_00520	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HPM96_00525	COG1172	Belongs to the binding-protein-dependent transport system permease family
HPM96_00530	COG1129	ABC transporter
HPM96_00535	COG1879	ABC-type sugar transport system periplasmic component
HPM96_00540	COG1737	Transcriptional regulator
HPM96_00545	COG0698	ribose 5-phosphate isomerase
HPM96_00555	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
HPM96_00560	COG0456	acetyltransferase
HPM96_00570	COG3454	Phosphonate metabolism
HPM96_00575	COG4778	phosphonate C-P lyase system protein PhnL
HPM96_00580	COG4107	phosphonate C-P lyase system protein PhnK
HPM96_00585	COG3627	carbon phosphorus lyase activity
HPM96_00590	COG3626	phosphonate metabolism
HPM96_00595	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
HPM96_00600	COG3624	Phosphonate C-P lyase system protein PhnG
HPM96_00605	COG2188	Transcriptional regulator
HPM96_00610	COG3639	organic phosphonate transmembrane transporter activity
HPM96_00615	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
HPM96_00625	COG2764	glyoxalase bleomycin resistance protein dioxygenase
HPM96_00630	COG2824	Alkylphosphonate utilization operon protein PhnA
HPM96_00635	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
HPM96_00645	COG0477	Major facilitator Superfamily
HPM96_00655	COG0642	Histidine kinase
HPM96_00660	COG0745	RESPONSE REGULATOR receiver
HPM96_00665	COG2194	sulfuric ester hydrolase activity
HPM96_00670	COG0531	amino acid
HPM96_00675	COG2207	Transcriptional regulator
HPM96_00680	COG1982	Orn Lys Arg decarboxylase major
HPM96_00685	COG2169	Transcriptional regulator
HPM96_00690	COG1486	melibiose metabolic process
HPM96_00695	COG3647	Membrane
HPM96_00700	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
HPM96_00700	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HPM96_00705	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HPM96_00710	COG4565	transcriptional regulatory protein
HPM96_00715	COG3290	protein histidine kinase activity
HPM96_00720	COG3592	Divergent 4Fe-4S mono-cluster
HPM96_00725	COG2388	GCN5-related N-acetyl-transferase
HPM96_00740	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HPM96_00745	COG3104	oligopeptide transport
HPM96_00750	COG1982	Orn Lys Arg decarboxylase major
HPM96_00755	COG0531	amino acid
HPM96_00760	COG3710	Transcriptional regulator
HPM96_00770	COG1309	transcriptional regulator
HPM96_00785	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HPM96_00790	COG1027	Aspartate ammonia-lyase
HPM96_00795	COG3030	protein affecting phage T7 exclusion by the F plasmid
HPM96_00800	COG0531	amino acid
HPM96_00825	COG1509	lysine 2,3-aminomutase activity
HPM96_00835	COG5510	response to toxic substance
HPM96_00840	COG5510	response to toxic substance
HPM96_00845	COG2076	Multidrug Resistance protein
HPM96_00850	COG3040	lipid binding
HPM96_00870	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HPM96_00875	COG1053	succinate dehydrogenase
HPM96_00885	COG0531	amino acid
HPM96_00910	COG3264	Mechanosensitive ion channel
HPM96_00910	COG1511	domain protein
HPM96_00955	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HPM96_00955	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HPM96_00960	COG0802	atpase or kinase
HPM96_00965	COG0860	N-Acetylmuramoyl-L-alanine amidase
HPM96_00985	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HPM96_00990	COG0330	HflC and HflK could
HPM96_00995	COG0330	HflC and HflK could
HPM96_01000	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
HPM96_01015	COG0557	exoribonuclease II activity
HPM96_01020	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HPM96_01025	COG3789	protein conserved in bacteria
HPM96_01030	COG1842	Phage shock protein A
HPM96_01040	COG3766	membrane
HPM96_01045	COG5463	Belongs to the UPF0441 family
HPM96_01050	COG0754	glutathionylspermidine amidase activity
HPM96_01055	COG1960	acyl-CoA dehydrogenase activity
HPM96_01065	COG3650	response to hydrogen peroxide
HPM96_01070	COG1073	alpha beta
HPM96_01085	COG3037	sugar-specific permease SgaT UlaA
HPM96_01130	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HPM96_01140	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HPM96_01150	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
HPM96_01155	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HPM96_01160	COG4670	ketone body catabolic process
HPM96_01165	COG1024	Enoyl-CoA hydratase
HPM96_01180	COG1309	transcriptional regulator
HPM96_01185	COG3061	Opacity-associated protein A
HPM96_01190	COG0545	Peptidyl-prolyl cis-trans isomerase
HPM96_01195	COG1113	amino acid transport
HPM96_01215	COG0697	spore germination
HPM96_01220	COG0702	epimerase
HPM96_01225	COG1733	regulation of RNA biosynthetic process
HPM96_01230	COG0737	Belongs to the 5'-nucleotidase family
HPM96_01235	COG1218	3'(2'),5'-bisphosphate nucleotidase
HPM96_01240	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
HPM96_01250	COG1253	flavin adenine dinucleotide binding
HPM96_01260	COG0729	surface antigen
HPM96_01265	COG2911	Protein conserved in bacteria
HPM96_01270	COG2105	PFAM AIG2 family protein
HPM96_01275	COG2336	PFAM SpoVT AbrB
HPM96_01280	COG2337	Toxic component of a toxin-antitoxin (TA) module
HPM96_01285	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HPM96_01290	COG1879	ABC-type sugar transport system periplasmic component
HPM96_01295	COG1129	ABC transporter
HPM96_01300	COG1172	Belongs to the binding-protein-dependent transport system permease family
HPM96_01305	COG1172	Belongs to the binding-protein-dependent transport system permease family
HPM96_01315	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HPM96_01325	COG0312	modulator of DNA gyrase
HPM96_01330	COG3783	Cytochrome b(562)
HPM96_01335	COG3077	Addiction module antitoxin, RelB DinJ family
HPM96_01340	COG2026	Addiction module toxin, RelE StbE family
HPM96_01345	COG0602	queuosine metabolic process
HPM96_01350	COG1328	CTP reductase activity
HPM96_01355	COG0366	Alpha amylase catalytic
HPM96_01360	COG1263	PTS System
HPM96_01360	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HPM96_01365	COG1609	Transcriptional regulator
HPM96_01375	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HPM96_01380	COG0251	oxidation-reduction process
HPM96_01400	COG0251	oxidation-reduction process
HPM96_01405	COG1028	Short-chain dehydrogenase reductase Sdr
HPM96_01410	COG1309	transcriptional regulator
HPM96_01415	COG2731	YhcH YjgK YiaL family protein
HPM96_01430	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
HPM96_01435	COG0456	acetyltransferase
HPM96_01440	COG4269	membrane
HPM96_01445	COG0525	valine-tRNA ligase activity
HPM96_01450	COG2927	DNA polymerase III (CHI subunit)
HPM96_01460	COG0795	lipopolysaccharide-transporting ATPase activity
HPM96_01465	COG0795	lipopolysaccharide-transporting ATPase activity
HPM96_01470	COG0433	COG0433 Predicted ATPase
HPM96_01475	COG1609	Transcriptional regulator
HPM96_01480	COG2610	gluconate transmembrane transporter activity
HPM96_01485	COG1028	Short-chain dehydrogenase reductase Sdr
HPM96_01490	COG1063	alcohol dehydrogenase
HPM96_01495	COG3265	gluconokinase activity
HPM96_01500	COG1064	alcohol dehydrogenase
HPM96_01515	COG0328	RNA-DNA hybrid ribonuclease activity
HPM96_01520	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HPM96_01520	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
HPM96_01530	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HPM96_01535	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
HPM96_01550	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
HPM96_01570	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
HPM96_01575	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
HPM96_01580	COG0582	viral genome integration into host DNA
HPM96_01585	COG4974	Belongs to the 'phage' integrase family
HPM96_01590	COG3539	Fimbrial protein
HPM96_01595	COG3539	Fimbrial protein
HPM96_01600	COG3121	Chaperone
HPM96_01605	COG3188	usher protein
HPM96_01610	COG3539	Fimbrial protein
HPM96_01615	COG3539	Fimbrial protein
HPM96_01620	COG3539	Fimbrial protein
HPM96_01625	COG2610	gluconate transmembrane transporter activity
HPM96_01635	COG0246	Mannitol dehydrogenase
HPM96_01640	COG2186	Transcriptional regulator
HPM96_01660	COG0583	DNA-binding transcription factor activity
HPM96_01665	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HPM96_01670	COG0700	Nucleoside recognition
HPM96_01675	COG3366	ferrous iron transmembrane transporter activity
HPM96_01685	COG0477	Major facilitator Superfamily
HPM96_01700	COG1924	4 iron, 4 sulfur cluster binding
HPM96_01705	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
HPM96_01710	COG2733	membrane
HPM96_01715	COG2814	Major facilitator Superfamily
HPM96_01730	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HPM96_01735	COG5457	Domain of unknown function (DUF1127)
HPM96_01755	COG1715	Restriction endonuclease
HPM96_01770	COG0523	cobalamin synthesis protein
HPM96_01775	COG2879	small protein
HPM96_01780	COG1966	Carbon starvation protein
HPM96_01790	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
HPM96_01800	COG4145	pantothenate transmembrane transporter activity
HPM96_01810	COG0840	transmembrane signaling receptor activity
HPM96_01815	COG2271	Major facilitator Superfamily
HPM96_01820	COG1802	Transcriptional regulator
HPM96_01825	COG1063	alcohol dehydrogenase
HPM96_01840	COG1484	DNA-dependent DNA replication
HPM96_01855	COG2966	Psort location CytoplasmicMembrane, score
HPM96_01860	COG2197	response regulator
HPM96_01865	COG2197	response regulator
HPM96_01870	COG4114	ferric iron reductase
HPM96_01900	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
HPM96_01905	COG0456	acetyltransferase
HPM96_01910	COG1011	Hydrolase
HPM96_01920	COG2131	deaminase
HPM96_01935	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
HPM96_01940	COG5532	Uncharacterized conserved protein (DUF2303)
HPM96_01965	COG3646	Phage regulatory protein
HPM96_01975	COG1846	Transcriptional regulator
HPM96_01985	COG4725	Belongs to the MT-A70-like family
HPM96_01995	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
HPM96_02005	COG1403	HNH endonuclease
HPM96_02010	COG0484	heat shock protein binding
HPM96_02020	COG1278	Cold shock
HPM96_02025	COG1278	Cold shock
HPM96_02045	COG3772	lysozyme
HPM96_02055	COG1278	Cold shock
HPM96_02085	COG4220	transposase activity
HPM96_02155	COG1196	nuclear chromosome segregation
HPM96_02190	COG5301	cellulose 1,4-beta-cellobiosidase activity
HPM96_02215	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HPM96_02240	COG2823	Periplasmic or secreted lipoprotein
HPM96_02250	COG4667	esterase of the alpha-beta hydrolase superfamily
HPM96_02255	COG0084	hydrolase, TatD family'
HPM96_02260	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HPM96_02265	COG1328	CTP reductase activity
HPM96_02300	COG3726	membrane protein affecting hemolysin expression
HPM96_02305	COG0560	Phosphoserine phosphatase
HPM96_02310	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HPM96_02315	COG1056	cytidyltransferase-related domain
HPM96_02315	COG3172	ATPase kinase involved in NAD metabolism
HPM96_02325	COG0488	(ABC) transporter
HPM96_02330	COG0741	lytic transglycosylase activity
HPM96_02350	COG3708	Transcriptional regulator
HPM96_02350	COG2207	Transcriptional regulator
HPM96_02355	COG3045	CreA protein
HPM96_02360	COG0745	RESPONSE REGULATOR receiver
HPM96_02365	COG2205	protein histidine kinase activity
HPM96_02370	COG4452	Inner membrane protein CreD
HPM96_02375	COG0745	RESPONSE REGULATOR receiver
HPM96_02385	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
HPM96_02395	COG0527	aspartate kinase activity
HPM96_02395	COG0460	homoserine dehydrogenase
HPM96_02405	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HPM96_02420	COG1115	amino acid carrier protein
HPM96_02430	COG0521	Mo-molybdopterin cofactor biosynthetic process
HPM96_02435	COG1584	GPR1 FUN34 yaaH family protein
HPM96_02440	COG4735	regulation of single-species biofilm formation
HPM96_02470	COG3119	arylsulfatase activity
HPM96_02480	COG3004	Na( ) H( ) antiporter that extrudes sodium in exchange for external protons
HPM96_02485	COG0583	DNA-binding transcription factor activity
HPM96_02510	COG0196	riboflavin kinase activity
HPM96_02525	COG1047	Peptidyl-prolyl cis-trans
HPM96_02545	COG0505	Belongs to the CarA family
HPM96_02550	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HPM96_02600	COG0644	oxidoreductase
HPM96_02605	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
HPM96_02610	COG2271	Major facilitator Superfamily
HPM96_02620	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HPM96_02620	COG0475	glutathione-regulated potassium exporter activity
HPM96_02625	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HPM96_02665	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HPM96_02675	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
HPM96_02680	COG0564	pseudouridine synthase activity
HPM96_02690	COG0417	DNA replication proofreading
HPM96_02695	COG0235	Class ii aldolase
HPM96_02710	COG4977	sequence-specific DNA binding
HPM96_02725	COG0586	Pfam SNARE associated Golgi protein
HPM96_02735	COG1178	ABC-type Fe3 transport system permease component
HPM96_02740	COG4143	(ABC) transporter
HPM96_02785	COG0583	DNA-binding transcription factor activity
HPM96_02795	COG0028	Belongs to the TPP enzyme family
HPM96_02800	COG0440	acetolactate synthase activity
HPM96_02810	COG1609	Transcriptional regulator
HPM96_02825	COG3116	cell division
HPM96_02830	COG0768	penicillin binding
HPM96_02835	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HPM96_02840	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HPM96_02855	COG0772	Belongs to the SEDS family
HPM96_02870	COG1181	Belongs to the D-alanine--D-alanine ligase family
HPM96_02875	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
HPM96_02880	COG0849	cell division
HPM96_02885	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HPM96_02905	COG0494	nUDIX hydrolase
HPM96_02920	COG0237	dephospho-CoA kinase activity
HPM96_02930	COG1459	type II secretion system
HPM96_02935	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HPM96_02940	COG4969	Belongs to the N-Me-Phe pilin family
HPM96_02945	COG0157	Belongs to the NadC ModD family
HPM96_02950	COG3023	N-Acetylmuramoyl-L-alanine amidase
HPM96_02955	COG3725	Membrane protein required for beta-lactamase induction
HPM96_02960	COG1113	amino acid transport
HPM96_02965	COG2186	Transcriptional regulator
HPM96_02970	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
HPM96_02975	COG0508	dehydrogenase complex catalyzes the overall conversion of
HPM96_02980	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HPM96_02985	COG3547	Transposase (IS116 IS110 IS902 family)
HPM96_02990	COG3064	Membrane
HPM96_02995	COG1049	propionate catabolic process, 2-methylcitrate cycle
HPM96_03020	COG2132	Multicopper oxidase
HPM96_03025	COG4993	Dehydrogenase
HPM96_03030	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
HPM96_03035	COG0288	reversible hydration of carbon dioxide
HPM96_03040	COG1131	(ABC) transporter
HPM96_03045	COG0842	Transport permease protein
HPM96_03050	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HPM96_03055	COG0726	polysaccharide deacetylase
HPM96_03065	COG5464	transposase or invertase
HPM96_03080	COG3539	Fimbrial protein
HPM96_03085	COG3539	Fimbrial protein
HPM96_03090	COG3539	Fimbrial protein
HPM96_03095	COG3539	Fimbrial protein
HPM96_03100	COG3188	usher protein
HPM96_03105	COG3121	Chaperone
HPM96_03110	COG3539	Fimbrial protein
HPM96_03115	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HPM96_03120	COG0617	tRNA 3'-terminal CCA addition
HPM96_03125	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HPM96_03130	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HPM96_03140	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
HPM96_03145	COG1643	Atp-dependent helicase
HPM96_03150	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HPM96_03155	COG4774	siderophore transport
HPM96_03160	COG1120	ATPase activity
HPM96_03165	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HPM96_03170	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HPM96_03195	COG2860	membrane
HPM96_03200	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HPM96_03215	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HPM96_03220	COG3835	regulator
HPM96_03240	COG0024	Methionine aminopeptidase
HPM96_03265	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HPM96_03270	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HPM96_03275	COG0575	Belongs to the CDS family
HPM96_03280	COG0750	zinc metalloprotease
HPM96_03290	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
HPM96_03295	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HPM96_03315	COG0164	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids
HPM96_03320	COG0587	DNA-directed DNA polymerase activity
HPM96_03335	COG0346	lactoylglutathione lyase activity
HPM96_03340	COG0037	tRNA processing
HPM96_03345	COG4568	rho-dependent transcription termination
HPM96_03355	COG4681	YaeQ
HPM96_03360	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
HPM96_03365	COG3015	lipoprotein NlpE involved in copper resistance
HPM96_03370	COG0791	NLP P60 protein
HPM96_03380	COG1720	tRNA m6t6A37 methyltransferase activity
HPM96_03390	COG1464	Belongs to the NlpA lipoprotein family
HPM96_03395	COG2011	ABC-type metal ion transport system permease component
HPM96_03405	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HPM96_03440	COG0656	L-ascorbic acid biosynthetic process
HPM96_03445	COG0583	DNA-binding transcription factor activity
HPM96_03455	COG2226	methyltransferase
HPM96_03460	COG0741	lytic transglycosylase activity
HPM96_03460	COG1388	LysM domain
HPM96_03470	COG2226	methyltransferase
HPM96_03480	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HPM96_03490	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HPM96_03500	COG1960	acyl-CoA dehydrogenase activity
HPM96_03510	COG0121	glutamine amidotransferase
HPM96_03515	COG3034	peptidoglycan biosynthetic process
HPM96_03525	COG3077	Addiction module antitoxin, RelB DinJ family
HPM96_03530	COG0791	NLP P60 protein
HPM96_03535	COG1943	Transposase
HPM96_03555	COG0454	-acetyltransferase
HPM96_03560	COG1690	Belongs to the RtcB family
HPM96_03565	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
HPM96_03580	COG2195	Cleaves the N-terminal amino acid of tripeptides
HPM96_03600	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HPM96_03620	COG0582	viral genome integration into host DNA
HPM96_03735	COG3477	response to acidic pH
HPM96_03740	COG0727	PFAM Uncharacterised protein family (UPF0153)
HPM96_03795	COG1902	pentaerythritol trinitrate reductase activity
HPM96_03800	COG1073	alpha beta
HPM96_03805	COG0583	DNA-binding transcription factor activity
HPM96_03815	COG0667	Aldo Keto reductase
HPM96_03820	COG0656	L-ascorbic acid biosynthetic process
HPM96_03825	COG1388	LysM domain
HPM96_03825	COG4932	domain protein
HPM96_03825	COG2373	Large extracellular alpha-helical protein
HPM96_03830	COG3708	Transcriptional regulator
HPM96_03830	COG2207	Transcriptional regulator
HPM96_03835	COG0656	L-ascorbic acid biosynthetic process
HPM96_03840	COG3059	membrane
HPM96_03850	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HPM96_03855	COG2207	Transcriptional regulator
HPM96_03860	COG0247	lactate metabolic process
HPM96_03865	COG1139	Iron-sulfur cluster binding protein
HPM96_03870	COG1556	Lactate utilization protein
HPM96_03895	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HPM96_03900	COG2200	EAL domain
HPM96_03900	COG2771	luxR family
HPM96_03905	COG0583	DNA-binding transcription factor activity
HPM96_03915	COG0666	response to abiotic stimulus
HPM96_03925	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HPM96_03930	COG1304	FMN binding
HPM96_03935	COG0549	Belongs to the carbamate kinase family
HPM96_03940	COG0402	S-adenosylhomocysteine deaminase activity
HPM96_03945	COG1064	alcohol dehydrogenase
HPM96_03960	COG1280	lysine exporter protein (LysE YggA)
HPM96_03970	COG3829	transcription factor binding
HPM96_03975	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
HPM96_03980	COG0372	Belongs to the citrate synthase family
HPM96_03985	COG2079	MmgE PrpD family protein
HPM96_03990	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HPM96_03995	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HPM96_04000	COG0402	S-adenosylhomocysteine deaminase activity
HPM96_04005	COG0583	DNA-binding transcription factor activity
HPM96_04010	COG0288	reversible hydration of carbon dioxide
HPM96_04020	COG2807	transmembrane transport
HPM96_04025	COG0110	maltose O-acetyltransferase activity
HPM96_04030	COG2223	nitrite transmembrane transporter activity
HPM96_04040	COG1609	Transcriptional regulator
HPM96_04045	COG1414	Transcriptional regulator
HPM96_04080	COG2814	Major facilitator Superfamily
HPM96_04085	COG3122	Protein conserved in bacteria
HPM96_04115	COG1215	transferase activity, transferring glycosyl groups
HPM96_04120	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HPM96_04125	COG4521	taurine ABC transporter
HPM96_04135	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HPM96_04140	COG2175	clavaminate synthase activity
HPM96_04145	COG0113	porphobilinogen synthase activity
HPM96_04150	COG3468	outer membrane autotransporter barrel domain protein
HPM96_04155	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HPM96_04160	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HPM96_04165	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
HPM96_04185	COG1181	Belongs to the D-alanine--D-alanine ligase family
HPM96_04200	COG1785	Belongs to the alkaline phosphatase family
HPM96_04210	COG3706	GGDEF domain
HPM96_04215	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HPM96_04235	COG4126	flavin adenine dinucleotide binding
HPM96_04260	COG1940	carbohydrate kinase activity
HPM96_04265	COG2814	Major facilitator Superfamily
HPM96_04270	COG0419	ATPase involved in DNA repair
HPM96_04275	COG0420	3'-5' exonuclease activity
HPM96_04280	COG0745	RESPONSE REGULATOR receiver
HPM96_04285	COG5002	protein histidine kinase activity
HPM96_04290	COG1114	Component of the transport system for branched-chain amino acids
HPM96_04295	COG1113	amino acid transport
HPM96_04300	COG0366	Alpha amylase catalytic
HPM96_04325	COG1862	Preprotein translocase
HPM96_04330	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HPM96_04335	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HPM96_04340	COG3609	addiction module antidote protein, CC2985 family
HPM96_04350	COG1403	HNH endonuclease
HPM96_04355	COG3248	Nucleoside-binding outer membrane protein
HPM96_04370	COG0675	Transposase, IS605 OrfB family
HPM96_04385	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HPM96_04385	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HPM96_04400	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
HPM96_04405	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HPM96_04410	COG0667	Aldo Keto reductase
HPM96_04420	COG0142	geranyltranstransferase activity
HPM96_04435	COG0693	protein deglycase activity
HPM96_04440	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HPM96_04450	COG2814	Major facilitator Superfamily
HPM96_04475	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
HPM96_04480	COG1845	cytochrome c oxidase, subunit III
HPM96_04485	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HPM96_04490	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HPM96_04495	COG2223	nitrite transmembrane transporter activity
HPM96_04500	COG3056	Lipoprotein
HPM96_04505	COG0271	Belongs to the BolA IbaG family
HPM96_04525	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HPM96_04530	COG0776	regulation of translation
HPM96_04535	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HPM96_04540	COG1555	photosystem II stabilization
HPM96_04545	COG0824	Thioesterase
HPM96_04555	COG4533	DNA binding
HPM96_04565	COG1522	sequence-specific DNA binding
HPM96_04570	COG1132	(ABC) transporter
HPM96_04575	COG1132	(ABC) transporter
HPM96_04580	COG0347	Belongs to the P(II) protein family
HPM96_04585	COG0004	ammonium transporteR
HPM96_04590	COG1946	Acyl-CoA thioesterase
HPM96_04595	COG3126	Type III secretion system lipoprotein chaperone (YscW)
HPM96_04600	COG3695	enzyme binding
HPM96_04610	COG5507	3-demethylubiquinone-9 3-methyltransferase
HPM96_04615	COG4943	cyclic-guanylate-specific phosphodiesterase activity
HPM96_04625	COG0110	maltose O-acetyltransferase activity
HPM96_04640	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HPM96_04645	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HPM96_04650	COG1309	transcriptional regulator
HPM96_04655	COG1196	nuclear chromosome segregation
HPM96_04655	COG3264	Mechanosensitive ion channel
HPM96_04665	COG3923	Primosomal replication protein n
HPM96_04670	COG2832	Protein of unknown function (DUF454)
HPM96_04680	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HPM96_04715	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HPM96_04720	COG3547	Transposase (IS116 IS110 IS902 family)
HPM96_04725	COG4651	solute:proton antiporter activity
HPM96_04725	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HPM96_04730	COG2223	nitrite transmembrane transporter activity
HPM96_04735	COG0737	Belongs to the 5'-nucleotidase family
HPM96_04740	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HPM96_04745	COG3735	TraB family
HPM96_04750	COG3549	Plasmid maintenance system killer
HPM96_04755	COG3093	addiction module antidote protein HigA
HPM96_04760	COG2217	Heavy metal translocating P-type atpase
HPM96_04770	COG0531	amino acid
HPM96_04775	COG0789	Transcriptional regulator
HPM96_04800	COG1585	Membrane protein implicated in regulation of membrane protease activity
HPM96_04805	COG0330	HflC and HflK could
HPM96_04810	COG4619	ABC transporter
HPM96_04815	COG0390	transport system, permease component
HPM96_04820	COG3118	belongs to the thioredoxin family
HPM96_04825	COG0300	oxidoreductase activity
HPM96_04830	COG2755	lipolytic protein G-D-S-L family
HPM96_04835	COG4181	ATPase activity
HPM96_04840	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
HPM96_04860	COG1414	Transcriptional regulator
HPM96_04865	COG3960	tartronate-semialdehyde synthase activity
HPM96_04870	COG3622	Belongs to the hyi family
HPM96_04875	COG2084	Dehydrogenase
HPM96_04880	COG1953	Uracil, thiamine, allantoin
HPM96_04890	COG2233	PERMEase
HPM96_04895	COG1929	Belongs to the glycerate kinase type-1 family
HPM96_04900	COG3257	ureidoglycine aminohydrolase activity
HPM96_04905	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HPM96_04910	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
HPM96_04915	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HPM96_04920	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HPM96_04930	COG0549	Belongs to the carbamate kinase family
HPM96_04935	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HPM96_04940	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HPM96_04950	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HPM96_04960	COG1988	membrane-bound metal-dependent
HPM96_04965	COG2501	S4 domain
HPM96_04975	COG3539	Fimbrial protein
HPM96_04980	COG3121	Chaperone
HPM96_04985	COG3188	usher protein
HPM96_04990	COG3539	Fimbrial protein
HPM96_04995	COG3539	Fimbrial protein
HPM96_05000	COG2197	response regulator
HPM96_05010	COG0582	viral genome integration into host DNA
HPM96_05100	COG2076	Multidrug Resistance protein
HPM96_05110	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HPM96_05195	COG4220	transposase activity
HPM96_05215	COG1030	water channel activity
HPM96_05265	COG1196	nuclear chromosome segregation
HPM96_05325	COG0500	methyltransferase
HPM96_05340	COG4571	Outer membrane protease
HPM96_05345	COG2207	Transcriptional regulator
HPM96_05355	COG4783	chaperone-mediated protein folding
HPM96_05360	COG1215	transferase activity, transferring glycosyl groups
HPM96_05365	COG5002	protein histidine kinase activity
HPM96_05370	COG0745	RESPONSE REGULATOR receiver
HPM96_05375	COG1538	Outer membrane efflux protein
HPM96_05380	COG5569	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HPM96_05385	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HPM96_05390	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HPM96_05395	COG1113	amino acid transport
HPM96_05400	COG0668	transmembrane transport
HPM96_05405	COG0778	Nitroreductase
HPM96_05410	COG2315	Protein conserved in bacteria
HPM96_05430	COG2977	Belongs to the P-Pant transferase superfamily
HPM96_05435	COG4771	TonB-dependent receptor
HPM96_05440	COG2382	esterase
HPM96_05445	COG3251	PFAM MbtH domain protein
HPM96_05450	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
HPM96_05450	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HPM96_05455	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
HPM96_05460	COG1120	ATPase activity
HPM96_05465	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HPM96_05470	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HPM96_05480	COG4592	Periplasmic binding protein
HPM96_05485	COG1169	isochorismate synthase
HPM96_05490	COG1021	2,3-dihydroxybenzoate-AMP ligase
HPM96_05495	COG1535	isochorismatase
HPM96_05495	COG3433	isochorismatase activity
HPM96_05500	COG1028	Short-chain dehydrogenase reductase Sdr
HPM96_05505	COG2050	protein possibly involved in aromatic compounds catabolism
HPM96_05510	COG1966	Carbon starvation protein
HPM96_05515	COG2879	small protein
HPM96_05520	COG0371	Dehydrogenase
HPM96_05525	COG0436	Aminotransferase
HPM96_05530	COG1475	DNA binding
HPM96_05535	COG3969	phosphoadenosine phosphosulfate
HPM96_05540	COG0583	DNA-binding transcription factor activity
HPM96_05545	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HPM96_05550	COG0450	alkyl hydroperoxide reductase
HPM96_05555	COG3634	alkyl hydroperoxide reductase activity
HPM96_05560	COG0589	response to stress
HPM96_05565	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HPM96_05570	COG3719	Belongs to the RNase T2 family
HPM96_05575	COG0471	metal ion transport
HPM96_05590	COG3051	citrate lyase alpha subunit
HPM96_05595	COG2301	Belongs to the HpcH HpaI aldolase family
HPM96_05605	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
HPM96_05610	COG3290	protein histidine kinase activity
HPM96_05615	COG4565	transcriptional regulatory protein
HPM96_05620	COG3069	C4-dicarboxylate transmembrane transporter activity
HPM96_05640	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HPM96_05645	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HPM96_05655	COG0583	DNA-binding transcription factor activity
HPM96_05670	COG1686	Belongs to the peptidase S11 family
HPM96_05675	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HPM96_05680	COG0772	Belongs to the SEDS family
HPM96_05685	COG0768	penicillin binding
HPM96_05695	COG0799	negative regulation of ribosome biogenesis
HPM96_05700	COG0406	alpha-ribazole phosphatase activity
HPM96_05710	COG1466	dna polymerase III delta subunit
HPM96_05725	COG2888	peptidyl-tyrosine sulfation
HPM96_05730	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
HPM96_05740	COG2214	Heat shock protein DnaJ domain protein
HPM96_05745	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
HPM96_05755	COG2214	Heat shock protein DnaJ domain protein
HPM96_05760	COG0443	Heat shock 70 kDa protein
HPM96_05770	COG1126	abc transporter atp-binding protein
HPM96_05775	COG0765	amino acid transport
HPM96_05780	COG0765	amino acid transport
HPM96_05785	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HPM96_05795	COG0815	Transfers the fatty acyl group on membrane lipoproteins
HPM96_05800	COG4535	Mg2 and Co2 transporter CorC
HPM96_05810	COG1702	phosphate starvation-inducible protein PhoH
HPM96_05820	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HPM96_05865	COG0367	asparagine synthase
HPM96_05870	COG0647	UMP catabolic process
HPM96_05875	COG1940	carbohydrate kinase activity
HPM96_05875	COG1846	Transcriptional regulator
HPM96_05880	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HPM96_05890	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HPM96_05890	COG1263	PTS System
HPM96_05890	COG2190	(PTS) system
HPM96_05910	COG0735	belongs to the Fur family
HPM96_05920	COG0716	FMN binding
HPM96_05930	COG0596	Alpha beta hydrolase
HPM96_05935	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
HPM96_05940	COG0033	Phosphoglucomutase
HPM96_05945	COG0531	amino acid
HPM96_05950	COG1982	Orn Lys Arg decarboxylase major
HPM96_05960	COG0745	RESPONSE REGULATOR receiver
HPM96_05965	COG2205	protein histidine kinase activity
HPM96_05995	COG3272	Protein of unknown function (DUF1722)
HPM96_06000	COG0415	Belongs to the DNA photolyase family
HPM96_06010	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HPM96_06015	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
HPM96_06020	COG1984	allophanate hydrolase subunit 2
HPM96_06035	COG3180	Ammonia monooxygenase
HPM96_06040	COG2186	Transcriptional regulator
HPM96_06045	COG0473	3-isopropylmalate dehydrogenase activity
HPM96_06045	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HPM96_06050	COG1063	alcohol dehydrogenase
HPM96_06055	COG1028	Short-chain dehydrogenase reductase Sdr
HPM96_06065	COG2721	sulfolactate sulfo-lyase activity
HPM96_06070	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HPM96_06080	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HPM96_06085	COG0372	Belongs to the citrate synthase family
HPM96_06095	COG2009	succinate dehydrogenase
HPM96_06100	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
HPM96_06105	COG1053	succinate dehydrogenase
HPM96_06110	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HPM96_06115	COG0567	Dehydrogenase, E1 component
HPM96_06120	COG0508	dehydrogenase complex catalyzes the overall conversion of
HPM96_06130	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HPM96_06140	COG2987	Catalyzes the conversion of urocanate to 4-imidazolone- 5-propionate
HPM96_06145	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HPM96_06155	COG1228	amidohydrolase
HPM96_06160	COG0010	Belongs to the arginase family
HPM96_06165	COG2986	histidine ammonia-lyase
HPM96_06170	COG0583	DNA-binding transcription factor activity
HPM96_06175	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
HPM96_06180	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
HPM96_06180	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HPM96_06185	COG1301	dicarboxylic acid transport
HPM96_06200	COG3799	methylaspartate ammonia-lyase activity
HPM96_06205	COG4865	methylaspartate mutase activity
HPM96_06215	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HPM96_06230	COG1271	oxidase subunit
HPM96_06235	COG1294	oxidase, subunit
HPM96_06240	COG4890	Cyd operon protein YbgT
HPM96_06245	COG3790	cyd operon protein YbgE
HPM96_06250	COG0824	Thioesterase
HPM96_06255	COG0811	peptide transport
HPM96_06260	COG0848	biopolymer transport protein
HPM96_06265	COG3064	Membrane
HPM96_06275	COG2885	chlorophyll binding
HPM96_06280	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
HPM96_06325	COG3201	nicotinamide mononucleotide transporter
HPM96_06330	COG1230	cation diffusion facilitator family transporter
HPM96_06340	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HPM96_06350	COG2017	converts alpha-aldose to the beta-anomer
HPM96_06360	COG1085	galactose-1-phosphate uridylyltransferase
HPM96_06365	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HPM96_06370	COG1119	ATPase activity
HPM96_06375	COG2005	Transcriptional regulator
HPM96_06375	COG3585	molybdate ion transport
HPM96_06385	COG0725	ABC transporter, periplasmic molybdate-binding protein
HPM96_06390	COG4149	molybdate abc transporter
HPM96_06400	COG0561	phosphatase activity
HPM96_06410	COG0583	DNA-binding transcription factor activity
HPM96_06415	COG2828	Protein conserved in bacteria
HPM96_06420	COG0471	metal ion transport
HPM96_06425	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HPM96_06430	COG4677	pectinesterase activity
HPM96_06435	COG1881	PFAM PEBP family protein
HPM96_06440	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HPM96_06455	COG2226	methyltransferase
HPM96_06460	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HPM96_06470	COG0391	Required for morphogenesis under gluconeogenic growth conditions
HPM96_06480	COG0521	Mo-molybdopterin cofactor biosynthetic process
HPM96_06490	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
HPM96_06495	COG0314	molybdopterin synthase activity
HPM96_06500	COG0670	Belongs to the BI1 family
HPM96_06505	COG0670	Belongs to the BI1 family
HPM96_06510	COG0392	lysyltransferase activity
HPM96_06515	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HPM96_06520	COG3568	Endonuclease Exonuclease Phosphatase
HPM96_06530	COG0842	Transport permease protein
HPM96_06535	COG0842	Transport permease protein
HPM96_06540	COG1131	(ABC) transporter
HPM96_06550	COG1309	transcriptional regulator
HPM96_06555	COG0513	Belongs to the DEAD box helicase family
HPM96_06570	COG1199	ATP-dependent helicase activity
HPM96_06575	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HPM96_06580	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
HPM96_06590	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HPM96_06600	COG4774	siderophore transport
HPM96_06615	COG0668	transmembrane transport
HPM96_06620	COG1126	abc transporter atp-binding protein
HPM96_06625	COG0765	amino acid transport
HPM96_06630	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HPM96_06640	COG5006	permease, DMT superfamily
HPM96_06650	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
HPM96_06655	COG2194	sulfuric ester hydrolase activity
HPM96_06665	COG1321	iron dependent repressor
HPM96_06670	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HPM96_06675	COG1376	ErfK ybiS ycfS ynhG family protein
HPM96_06680	COG0488	(ABC) transporter
HPM96_06695	COG0561	phosphatase activity
HPM96_06700	COG1882	Formate acetyltransferase
HPM96_06705	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HPM96_06710	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HPM96_06715	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HPM96_06720	COG0303	'Molybdopterin
HPM96_06725	COG1446	asparaginase
HPM96_06735	COG0747	negative chemotaxis
HPM96_06750	COG2200	EAL domain
HPM96_06755	COG2199	diguanylate cyclase activity
HPM96_06780	COG2133	pyrroloquinoline quinone binding
HPM96_06785	COG0625	glutathione transferase activity
HPM96_06790	COG1686	Belongs to the peptidase S11 family
HPM96_06795	COG1349	DNA-binding transcription factor activity
HPM96_06800	COG0671	phosphoesterase, PA-phosphatase related
HPM96_06805	COG2814	Major facilitator Superfamily
HPM96_06815	COG0561	phosphatase activity
HPM96_06820	COG0738	Major facilitator superfamily
HPM96_06825	COG3226	Transcriptional regulator
HPM96_06840	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HPM96_06850	COG0778	Nitroreductase
HPM96_06865	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HPM96_06870	COG3842	ATPase activity
HPM96_06875	COG1176	ABC-type spermidine putrescine transport system, permease component I
HPM96_06880	COG1177	transmembrane transport
HPM96_06895	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HPM96_06900	COG4160	amino acid transport
HPM96_06905	COG4215	(ABC) transporter
HPM96_06910	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HPM96_06915	COG1126	abc transporter atp-binding protein
HPM96_06935	COG3023	N-Acetylmuramoyl-L-alanine amidase
HPM96_06940	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HPM96_06945	COG0702	epimerase
HPM96_06950	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
HPM96_06955	COG0028	Belongs to the TPP enzyme family
HPM96_06960	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HPM96_06965	COG1151	hydroxylamine reductase activity
HPM96_06970	COG2431	L-lysine efflux transmembrane transporter activity
HPM96_06990	COG1028	Short-chain dehydrogenase reductase Sdr
HPM96_06995	COG0586	Pfam SNARE associated Golgi protein
HPM96_07005	COG1686	Belongs to the peptidase S11 family
HPM96_07010	COG0277	FAD linked oxidase domain protein
HPM96_07015	COG1472	Belongs to the glycosyl hydrolase 3 family
HPM96_07020	COG1732	Glycine betaine
HPM96_07025	COG1174	glycine betaine transport
HPM96_07030	COG1125	glycine betaine transport
HPM96_07035	COG1174	glycine betaine transport
HPM96_07045	COG0789	Transcriptional regulator
HPM96_07050	COG3275	phosphorelay sensor kinase activity
HPM96_07055	COG3279	Response regulator of the LytR AlgR family
HPM96_07060	COG4807	Protein conserved in bacteria
HPM96_07065	COG4808	Protein conserved in bacteria
HPM96_07070	COG4715	Zinc finger, swim domain protein
HPM96_07075	COG3552	Protein containing von Willebrand factor type A (VWA) domain
HPM96_07080	COG2425	protein containing a von Willebrand factor type A (vWA) domain
HPM96_07085	COG0714	Associated with various cellular activities
HPM96_07095	COG3831	ATPase activity
HPM96_07100	COG3831	ATPase activity
HPM96_07105	COG3831	ATPase activity
HPM96_07115	COG0489	protein tyrosine kinase activity
HPM96_07125	COG3539	Fimbrial protein
HPM96_07130	COG3121	Chaperone
HPM96_07135	COG3188	usher protein
HPM96_07140	COG3539	Fimbrial protein
HPM96_07145	COG5455	response to cobalt ion
HPM96_07150	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
HPM96_07210	COG0351	phosphomethylpyrimidine kinase
HPM96_07215	COG3757	hydrolase, family 25
HPM96_07220	COG2188	Transcriptional regulator
HPM96_07225	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HPM96_07230	COG1397	ADP-ribosylglycohydrolase
HPM96_07235	COG2211	Major facilitator Superfamily
HPM96_07240	COG1830	Aldolase
HPM96_07255	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HPM96_07260	COG3414	Phosphotransferase system galactitol-specific IIB component
HPM96_07265	COG3775	system Galactitol-specific IIC component
HPM96_07270	COG1063	alcohol dehydrogenase
HPM96_07300	COG3609	addiction module antidote protein, CC2985 family
HPM96_07310	COG0745	RESPONSE REGULATOR receiver
HPM96_07315	COG2205	protein histidine kinase activity
HPM96_07365	COG4245	von Willebrand factor, type A
HPM96_07370	COG0631	protein serine/threonine phosphatase activity
HPM96_07375	COG4248	protein with protein kinase and helix-hairpin-helix DNA-binding domains
HPM96_07380	COG0443	Heat shock 70 kDa protein
HPM96_07385	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
HPM96_07390	COG3447	MASE1 domain protein
HPM96_07390	COG5002	protein histidine kinase activity
HPM96_07390	COG5001	Diguanylate cyclase
HPM96_07395	COG0572	uridine kinase
HPM96_07405	COG2982	Protein involved in outer membrane biogenesis
HPM96_07420	COG1253	flavin adenine dinucleotide binding
HPM96_07430	COG1596	polysaccharide export
HPM96_07435	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HPM96_07440	COG3206	protein involved in exopolysaccharide biosynthesis
HPM96_07440	COG0489	protein tyrosine kinase activity
HPM96_07445	COG0463	Glycosyl transferase, family 2
HPM96_07450	COG1045	serine acetyltransferase
HPM96_07455	COG0438	transferase activity, transferring glycosyl groups
HPM96_07465	COG1216	Glycosyl transferase, family 2
HPM96_07470	COG0110	maltose O-acetyltransferase activity
HPM96_07475	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
HPM96_07480	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HPM96_07485	COG1051	belongs to the nudix hydrolase family
HPM96_07490	COG0297	glycogen (starch) synthase activity
HPM96_07495	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
HPM96_07495	COG0662	Cupin 2, conserved barrel domain protein
HPM96_07500	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HPM96_07505	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HPM96_07510	COG2244	polysaccharide biosynthetic process
HPM96_07515	COG2327	Polysaccharide pyruvyl transferase
HPM96_07520	COG0438	transferase activity, transferring glycosyl groups
HPM96_07530	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HPM96_07535	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HPM96_07540	COG2244	polysaccharide biosynthetic process
HPM96_07545	COG1216	Glycosyl transferase, family 2
HPM96_07570	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
HPM96_07575	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HPM96_07595	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HPM96_07600	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
HPM96_07605	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
HPM96_07610	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
HPM96_07630	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HPM96_07635	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HPM96_07635	COG0131	Imidazoleglycerol-phosphate dehydratase
HPM96_07645	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HPM96_07660	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HPM96_07665	COG0583	DNA-binding transcription factor activity
HPM96_07675	COG0531	amino acid
HPM96_07680	COG2391	methyltransferase activity
HPM96_07685	COG0425	Belongs to the sulfur carrier protein TusA family
HPM96_07690	COG2925	Exonuclease
HPM96_07695	COG1686	Belongs to the peptidase S11 family
HPM96_07705	COG1289	transmembrane transporter activity
HPM96_07715	COG4917	ethanolamine utilization protein
HPM96_07750	COG2003	Belongs to the UPF0758 family
HPM96_07855	COG1735	metal-dependent hydrolase with the TIM-barrel fold
HPM96_07870	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HPM96_07890	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HPM96_07900	COG0583	DNA-binding transcription factor activity
HPM96_07910	COG2271	Major facilitator Superfamily
HPM96_07920	COG0800	Aldolase
HPM96_07925	COG3734	2-keto-3-deoxy-galactonokinase
HPM96_07930	COG2186	Transcriptional regulator
HPM96_07955	COG0477	Major facilitator Superfamily
HPM96_07970	COG1285	pathogenesis
HPM96_07990	COG1446	asparaginase
HPM96_08010	COG3069	C4-dicarboxylate transmembrane transporter activity
HPM96_08015	COG2195	Cleaves the N-terminal amino acid of tripeptides
HPM96_08025	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HPM96_08030	COG0252	asparaginase activity
HPM96_08035	COG4565	transcriptional regulatory protein
HPM96_08040	COG2186	Transcriptional regulator
HPM96_08045	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HPM96_08050	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HPM96_08055	COG0165	Argininosuccinate lyase
HPM96_08070	COG3969	phosphoadenosine phosphosulfate
HPM96_08075	COG1475	DNA binding
HPM96_08080	COG4771	TonB-dependent receptor
HPM96_08085	COG2087	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate
HPM96_08100	COG1376	ErfK ybiS ycfS ynhG family protein
HPM96_08110	COG0583	DNA-binding transcription factor activity
HPM96_08115	COG0583	DNA-binding transcription factor activity
HPM96_08125	COG0534	Mate efflux family protein
HPM96_08135	COG0217	transcriptional regulatory protein
HPM96_08140	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HPM96_08145	COG0477	Major facilitator Superfamily
HPM96_08155	COG1388	LysM domain
HPM96_08155	COG1470	cell adhesion involved in biofilm formation
HPM96_08160	COG4932	domain protein
HPM96_08160	COG1388	LysM domain
HPM96_08160	COG2373	Large extracellular alpha-helical protein
HPM96_08165	COG4771	TonB-dependent receptor
HPM96_08170	COG1021	2,3-dihydroxybenzoate-AMP ligase
HPM96_08190	COG2226	methyltransferase
HPM96_08190	COG3433	isochorismatase activity
HPM96_08190	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HPM96_08205	COG1132	(ABC) transporter
HPM96_08210	COG2814	Major facilitator Superfamily
HPM96_08215	COG1169	isochorismate synthase
HPM96_08220	COG0582	viral genome integration into host DNA
HPM96_08240	COG3038	cytochrome b561
HPM96_08245	COG3443	Belongs to the bacterial solute-binding protein 9 family
HPM96_08260	COG2351	hydroxyisourate hydrolase activity
HPM96_08265	COG0745	RESPONSE REGULATOR receiver
HPM96_08270	COG2205	protein histidine kinase activity
HPM96_08280	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HPM96_08290	COG1418	mRNA catabolic process
HPM96_08295	COG0270	DNA (cytosine-5-)-methyltransferase activity
HPM96_08300	COG3727	T/G mismatch-specific endonuclease activity
HPM96_08305	COG0697	spore germination
HPM96_08310	COG2354	Protein conserved in bacteria
HPM96_08315	COG5475	Uncharacterized small protein (DUF2158)
HPM96_08340	COG2197	response regulator
HPM96_08345	COG1684	flagellar biosynthetic protein fliR
HPM96_08350	COG1987	bacterial-type flagellum assembly
HPM96_08355	COG1338	Plays a role in the flagellum-specific transport system
HPM96_08360	COG3190	flagellar
HPM96_08365	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HPM96_08370	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HPM96_08375	COG1580	Controls the rotational direction of flagella during chemotaxis
HPM96_08380	COG3144	bacterial-type flagellum assembly
HPM96_08385	COG2882	bacterial-type flagellum organization
HPM96_08390	COG1157	protein secretion by the type III secretion system
HPM96_08395	COG1317	bacterial-type flagellum organization
HPM96_08400	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HPM96_08405	COG1766	The M ring may be actively involved in energy transduction
HPM96_08415	COG2135	peptidase activity
HPM96_08420	COG0425	Belongs to the sulfur carrier protein TusA family
HPM96_08425	COG2391	methyltransferase activity
HPM96_08435	COG0366	Alpha amylase catalytic
HPM96_08445	COG1516	flagellar protein fliS
HPM96_08450	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
HPM96_08460	COG1191	sigma factor activity
HPM96_08490	COG2197	response regulator
HPM96_08505	COG2197	response regulator
HPM96_08535	COG3012	SEC-C Motif Domain Protein
HPM96_08535	COG3318	Belongs to the UPF0149 family
HPM96_08540	COG0814	amino acid
HPM96_08550	COG1528	Iron-storage protein
HPM96_08570	COG1528	Iron-storage protein
HPM96_08575	COG1879	ABC-type sugar transport system periplasmic component
HPM96_08580	COG1129	ABC transporter
HPM96_08585	COG1172	Belongs to the binding-protein-dependent transport system permease family
HPM96_08590	COG1877	trehalose-phosphatase activity
HPM96_08600	COG0589	response to stress
HPM96_08615	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
HPM96_08620	COG1360	Flagellar Motor Protein
HPM96_08625	COG0643	Histidine kinase
HPM96_08625	COG2198	Histidine kinase
HPM96_08630	COG0835	chemotaxis
HPM96_08635	COG0840	transmembrane signaling receptor activity
HPM96_08640	COG0840	transmembrane signaling receptor activity
HPM96_08645	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
HPM96_08655	COG0745	RESPONSE REGULATOR receiver
HPM96_08660	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
HPM96_08665	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HPM96_08670	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HPM96_08685	COG3102	Protein conserved in bacteria
HPM96_08695	COG3005	denitrification pathway
HPM96_08700	COG0243	molybdopterin cofactor binding
HPM96_08715	COG3788	relative of glutathione S-transferase, MAPEG superfamily
HPM96_08720	COG1801	Protein of unknown function DUF72
HPM96_08725	COG1335	isochorismatase
HPM96_08735	COG0494	nUDIX hydrolase
HPM96_08740	COG0217	transcriptional regulatory protein
HPM96_08775	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HPM96_08785	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
HPM96_08790	COG0739	heme binding
HPM96_08795	COG1560	Kdo2-lipid A biosynthetic process
HPM96_08800	COG0469	pyruvate kinase activity
HPM96_08805	COG1737	Transcriptional regulator
HPM96_08810	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HPM96_08815	COG0129	dihydroxy-acid dehydratase activity
HPM96_08820	COG0800	Aldolase
HPM96_08830	COG3141	response to X-ray
HPM96_08840	COG2979	Protein of unknown function (DUF533)
HPM96_08845	COG1770	oligopeptidase
HPM96_08850	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HPM96_08855	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HPM96_08865	COG2372	response to copper ion
HPM96_08870	COG1276	copper resistance
HPM96_08880	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HPM96_08900	COG3008	intermembrane lipid transfer
HPM96_08905	COG2995	paraquat-inducible protein a
HPM96_08910	COG1956	GAF domain-containing protein
HPM96_08920	COG0793	Belongs to the peptidase S41A family
HPM96_08930	COG2814	Major facilitator Superfamily
HPM96_08935	COG1414	Transcriptional regulator
HPM96_08965	COG2226	methyltransferase
HPM96_08980	COG3716	PTS system mannose fructose sorbose family IID component
HPM96_08985	COG3715	PTS system
HPM96_08990	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HPM96_08990	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HPM96_08995	COG1253	flavin adenine dinucleotide binding
HPM96_09000	COG2200	EAL domain
HPM96_09005	COG1760	l-serine dehydratase
HPM96_09010	COG0494	nUDIX hydrolase
HPM96_09015	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HPM96_09030	COG0251	oxidation-reduction process
HPM96_09035	COG1199	ATP-dependent helicase activity
HPM96_09040	COG1214	PFAM Peptidase M22, glycoprotease
HPM96_09045	COG3065	identical protein binding
HPM96_09050	COG0318	PFAM AMP-dependent synthetase and ligase
HPM96_09055	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
HPM96_09060	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HPM96_09065	COG4638	Rieske (2fe-2S)
HPM96_09070	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HPM96_09075	COG0473	3-isopropylmalate dehydrogenase activity
HPM96_09080	COG0583	DNA-binding transcription factor activity
HPM96_09090	COG3615	Tellurite resistance protein tehB
HPM96_09100	COG2261	transglycosylase associated protein
HPM96_09115	COG2203	Gaf domain
HPM96_09115	COG2199	diguanylate cyclase activity
HPM96_09120	COG3042	response to heat
HPM96_09125	COG3189	MarR family transcriptional regulator
HPM96_09130	COG2807	transmembrane transport
HPM96_09135	COG2207	Transcriptional regulator
HPM96_09150	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HPM96_09155	COG2199	diguanylate cyclase activity
HPM96_09160	COG2199	diguanylate cyclase activity
HPM96_09170	COG2766	serine protein kinase
HPM96_09175	COG3713	MltA-interacting MipA family protein
HPM96_09180	COG0656	L-ascorbic acid biosynthetic process
HPM96_09185	COG0676	glucose-6-phosphate 1-epimerase activity
HPM96_09190	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HPM96_09200	COG3139	Protein of unknown function (DUF1315)
HPM96_09205	COG1063	alcohol dehydrogenase
HPM96_09210	COG2271	Major facilitator Superfamily
HPM96_09215	COG1063	alcohol dehydrogenase
HPM96_09220	COG0191	fructose-bisphosphate aldolase activity
HPM96_09225	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HPM96_09230	COG0667	Aldo Keto reductase
HPM96_09235	COG1349	DNA-binding transcription factor activity
HPM96_09240	COG2814	Major facilitator Superfamily
HPM96_09245	COG1335	isochorismatase
HPM96_09250	COG0252	asparaginase activity
HPM96_09255	COG0616	signal peptide processing
HPM96_09260	COG0778	Nitroreductase
HPM96_09265	COG0709	Synthesizes selenophosphate from selenide and ATP
HPM96_09270	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HPM96_09275	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HPM96_09285	COG0494	nUDIX hydrolase
HPM96_09290	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HPM96_09295	COG2897	thiosulfate sulfurtransferase activity
HPM96_09300	COG4136	ATPase activity
HPM96_09305	COG4135	transport system, permease component
HPM96_09310	COG4134	Bacterial extracellular solute-binding protein
HPM96_09315	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HPM96_09320	COG0398	Pfam SNARE associated Golgi protein
HPM96_09330	COG0398	Pfam SNARE associated Golgi protein
HPM96_09335	COG0708	Exodeoxyribonuclease III
HPM96_09365	COG3678	ATP-independent chaperone mediated protein folding
HPM96_09375	COG0322	excinuclease ABC activity
HPM96_09385	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HPM96_09390	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HPM96_09395	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HPM96_09400	COG1447	Phosphotransferase system cellobiose-specific component IIA
HPM96_09405	COG1917	Cupin 2, conserved barrel domain protein
HPM96_09405	COG2169	Transcriptional regulator
HPM96_09410	COG1486	melibiose metabolic process
HPM96_09415	COG3394	polysaccharide catabolic process
HPM96_09420	COG0753	catalase activity
HPM96_09440	COG1988	membrane-bound metal-dependent
HPM96_09445	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HPM96_09455	COG3001	Fructosamine kinase
HPM96_09465	COG1105	Belongs to the carbohydrate kinase PfkB family
HPM96_09470	COG3137	Salt-induced outer membrane protein
HPM96_09530	COG0386	Belongs to the glutathione peroxidase family
HPM96_09540	COG0791	NLP P60 protein
HPM96_09545	COG2200	EAL domain
HPM96_09555	COG4256	Hemin uptake protein
HPM96_09560	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HPM96_09570	COG0574	Belongs to the PEP-utilizing enzyme family
HPM96_09570	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HPM96_09575	COG0471	metal ion transport
HPM96_09580	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HPM96_09590	COG1028	Short-chain dehydrogenase reductase Sdr
HPM96_09595	COG0318	PFAM AMP-dependent synthetase and ligase
HPM96_09600	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
HPM96_09605	COG0644	oxidoreductase
HPM96_09610	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
HPM96_09615	COG2086	electron transfer activity
HPM96_09620	COG1917	Cupin 2, conserved barrel domain protein
HPM96_09620	COG2207	Transcriptional regulator
HPM96_09625	COG1960	acyl-CoA dehydrogenase activity
HPM96_09630	COG4670	ketone body catabolic process
HPM96_09645	COG2271	Major facilitator Superfamily
HPM96_09650	COG0738	Major facilitator superfamily
HPM96_09665	COG0628	permease
HPM96_09670	COG0247	lactate metabolic process
HPM96_09670	COG0277	FAD linked oxidase domain protein
HPM96_09675	COG2050	protein possibly involved in aromatic compounds catabolism
HPM96_09685	COG0316	Belongs to the HesB IscA family
HPM96_09690	COG0719	Fe-S assembly protein
HPM96_09695	COG0396	ATPase activity
HPM96_09700	COG0719	Fe-S assembly protein
HPM96_09715	COG1376	ErfK ybiS ycfS ynhG family protein
HPM96_09720	COG4238	major outer membrane lipoprotein
HPM96_09725	COG0469	pyruvate kinase activity
HPM96_09735	COG0437	4 iron, 4 sulfur cluster binding
HPM96_09740	COG2414	aldehyde ferredoxin oxidoreductase
HPM96_09750	COG0437	4 iron, 4 sulfur cluster binding
HPM96_09755	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
HPM96_09765	COG4529	Protein conserved in bacteria
HPM96_09785	COG3468	outer membrane autotransporter barrel domain protein
HPM96_09795	COG0307	riboflavin synthase, alpha
HPM96_09800	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HPM96_09805	COG2814	Major facilitator Superfamily
HPM96_09810	COG0583	DNA-binding transcription factor activity
HPM96_09825	COG2814	Major facilitator Superfamily
HPM96_09830	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HPM96_09835	COG0791	NLP P60 protein
HPM96_09840	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
HPM96_09845	COG1201	RNA secondary structure unwinding
HPM96_09855	COG0346	lactoylglutathione lyase activity
HPM96_09860	COG1902	pentaerythritol trinitrate reductase activity
HPM96_09865	COG1309	transcriptional regulator
HPM96_09870	COG3313	Fe-S protein
HPM96_09875	COG4989	oxidoreductase activity
HPM96_09880	COG2032	superoxide dismutase activity
HPM96_09885	COG1289	transmembrane transporter activity
HPM96_09890	COG1566	PFAM secretion protein HlyD family protein
HPM96_09905	COG3133	Outer membrane lipoprotein
HPM96_09915	COG3895	Periplasmic Protein
HPM96_09930	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
HPM96_09935	COG0625	glutathione transferase activity
HPM96_09940	COG3104	oligopeptide transport
HPM96_09945	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HPM96_09955	COG4659	FMN binding
HPM96_09995	COG0673	inositol 2-dehydrogenase activity
HPM96_10005	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HPM96_10010	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HPM96_10010	COG1263	PTS System
HPM96_10015	COG1609	Transcriptional regulator
HPM96_10020	COG1028	Short-chain dehydrogenase reductase Sdr
HPM96_10025	COG1309	transcriptional regulator
HPM96_10030	COG3250	beta-galactosidase activity
HPM96_10045	COG5339	Protein conserved in bacteria
HPM96_10050	COG1482	cell wall glycoprotein biosynthetic process
HPM96_10055	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HPM96_10055	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
HPM96_10060	COG0114	fumarate hydratase activity
HPM96_10070	COG2205	protein histidine kinase activity
HPM96_10075	COG0745	RESPONSE REGULATOR receiver
HPM96_10080	COG3136	membrane protein required for alginate biosynthesis
HPM96_10090	COG0531	amino acid
HPM96_10100	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
HPM96_10105	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
HPM96_10110	COG0628	permease
HPM96_10125	COG3591	Belongs to the peptidase S1B family
HPM96_10140	COG2814	Major facilitator Superfamily
HPM96_10145	COG0583	DNA-binding transcription factor activity
HPM96_10150	COG1940	carbohydrate kinase activity
HPM96_10155	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HPM96_10165	COG3381	protein complex oligomerization
HPM96_10170	COG3302	dmso reductase anchor subunit
HPM96_10175	COG0437	4 iron, 4 sulfur cluster binding
HPM96_10180	COG0243	molybdopterin cofactor binding
HPM96_10185	COG0243	molybdopterin cofactor binding
HPM96_10200	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HPM96_10215	COG4948	Mandelate Racemase Muconate Lactonizing
HPM96_10220	COG1063	alcohol dehydrogenase
HPM96_10225	COG0477	Major facilitator Superfamily
HPM96_10230	COG0246	Mannitol dehydrogenase
HPM96_10240	COG1802	Transcriptional regulator
HPM96_10245	COG4221	oxidoreductase activity
HPM96_10250	COG0339	signal peptide processing
HPM96_10255	COG3111	PFAM Bacterial OB fold (BOF) protein
HPM96_10260	COG3706	GGDEF domain
HPM96_10280	COG2814	Major facilitator Superfamily
HPM96_10285	COG0697	spore germination
HPM96_10290	COG2188	Transcriptional regulator
HPM96_10305	COG1447	Phosphotransferase system cellobiose-specific component IIA
HPM96_10315	COG2723	6-phospho-beta-galactosidase activity
HPM96_10325	COG4977	sequence-specific DNA binding
HPM96_10330	COG1846	Transcriptional regulator
HPM96_10350	COG0583	DNA-binding transcription factor activity
HPM96_10355	COG1012	belongs to the aldehyde dehydrogenase family
HPM96_10360	COG2066	Belongs to the glutaminase family
HPM96_10370	COG2199	diguanylate cyclase activity
HPM96_10380	COG3781	membrane
HPM96_10445	COG3539	Fimbrial protein
HPM96_10450	COG3121	Chaperone
HPM96_10455	COG3188	usher protein
HPM96_10460	COG3539	Fimbrial protein
HPM96_10465	COG3539	Fimbrial protein
HPM96_10470	COG3539	Fimbrial protein
HPM96_10475	COG0243	molybdopterin cofactor binding
HPM96_10490	COG3119	arylsulfatase activity
HPM96_10495	COG0641	radical SAM
HPM96_10530	COG2801	Transposase and inactivated derivatives
HPM96_10570	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HPM96_10575	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HPM96_10635	COG3300	MHYT domain
HPM96_10635	COG5001	Diguanylate cyclase
HPM96_10685	COG4771	TonB-dependent receptor
HPM96_10690	COG0612	Peptidase, M16
HPM96_10695	COG0076	glutamate decarboxylase activity
HPM96_10700	COG0531	amino acid
HPM96_10715	COG2200	EAL domain
HPM96_10715	COG2199	diguanylate cyclase activity
HPM96_10715	COG2202	Pas domain
HPM96_10720	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
HPM96_10725	COG0747	negative chemotaxis
HPM96_10730	COG0601	transmembrane transport
HPM96_10735	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HPM96_10740	COG0444	Belongs to the ABC transporter superfamily
HPM96_10745	COG4608	Belongs to the ABC transporter superfamily
HPM96_10750	COG1764	response to oxidative stress
HPM96_10770	COG1064	alcohol dehydrogenase
HPM96_10780	COG3093	addiction module antidote protein HigA
HPM96_10785	COG2864	formate dehydrogenase
HPM96_10790	COG0437	4 iron, 4 sulfur cluster binding
HPM96_10800	COG0697	spore germination
HPM96_10810	COG4886	Leucine-rich repeat (LRR) protein
HPM96_10815	COG4886	Leucine-rich repeat (LRR) protein
HPM96_10820	COG2223	nitrite transmembrane transporter activity
HPM96_10825	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
HPM96_10830	COG1140	nitrate reductase beta subunit
HPM96_10835	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
HPM96_10840	COG2181	nitrate reductase activity
HPM96_10845	COG0384	phenazine biosynthesis protein PhzF
HPM96_10855	COG2162	N-hydroxyarylamine O-acetyltransferase activity
HPM96_10860	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HPM96_10870	COG2015	COG2015, Alkyl sulfatase and related hydrolases
HPM96_10875	COG2203	Gaf domain
HPM96_10875	COG5001	Diguanylate cyclase
HPM96_10875	COG4251	negative regulation of phosphorylation
HPM96_10875	COG3706	GGDEF domain
HPM96_10880	COG0625	glutathione transferase activity
HPM96_10885	COG1113	amino acid transport
HPM96_10895	COG4772	TonB-dependent receptor
HPM96_10900	COG1802	Transcriptional regulator
HPM96_10905	COG2130	NADP-dependent
HPM96_10910	COG1247	-acetyltransferase
HPM96_10915	COG3238	Protein conserved in bacteria
HPM96_10940	COG1177	transmembrane transport
HPM96_10945	COG1176	ABC-type spermidine putrescine transport system, permease component I
HPM96_10950	COG3842	ATPase activity
HPM96_10955	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HPM96_10960	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HPM96_10975	COG0826	peptidase U32
HPM96_10980	COG1396	sequence-specific DNA binding
HPM96_10985	COG3135	benzoate transporter
HPM96_10990	COG0675	Transposase, IS605 OrfB family
HPM96_11005	COG0500	methyltransferase
HPM96_11010	COG1275	C4-dicarboxylate transporter malic acid transport protein
HPM96_11015	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HPM96_11020	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HPM96_11025	COG2841	Protein conserved in bacteria
HPM96_11035	COG5383	Protein conserved in bacteria
HPM96_11040	COG0583	DNA-binding transcription factor activity
HPM96_11045	COG0840	transmembrane signaling receptor activity
HPM96_11065	COG3038	cytochrome b561
HPM96_11070	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HPM96_11075	COG1012	belongs to the aldehyde dehydrogenase family
HPM96_11080	COG1434	Gram-negative-bacterium-type cell wall biogenesis
HPM96_11085	COG1643	Atp-dependent helicase
HPM96_11095	COG2453	phosphatase
HPM96_11095	COG0671	phosphoesterase, PA-phosphatase related
HPM96_11100	COG2267	carboxylic ester hydrolase activity
HPM96_11105	COG4589	Belongs to the CDS family
HPM96_11110	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HPM96_11120	COG0667	Aldo Keto reductase
HPM96_11125	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HPM96_11130	COG3327	negative regulation of DNA-templated transcription, initiation
HPM96_11135	COG2207	Transcriptional regulator
HPM96_11140	COG3784	Protein of unknown function (DUF1318)
HPM96_11150	COG2911	Protein conserved in bacteria
HPM96_11155	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HPM96_11160	COG3187	Heat shock protein
HPM96_11165	COG3042	response to heat
HPM96_11170	COG0674	pyruvate-flavodoxin oxidoreductase activity
HPM96_11170	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HPM96_11170	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HPM96_11170	COG1013	pyruvate-flavodoxin oxidoreductase activity
HPM96_11175	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HPM96_11180	COG0589	response to stress
HPM96_11190	COG0513	Belongs to the DEAD box helicase family
HPM96_11200	COG3706	GGDEF domain
HPM96_11205	COG2840	Smr protein MutS2
HPM96_11210	COG0583	DNA-binding transcription factor activity
HPM96_11215	COG1473	amidohydrolase
HPM96_11220	COG1473	amidohydrolase
HPM96_11225	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
HPM96_11230	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HPM96_11235	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HPM96_11240	COG0589	response to stress
HPM96_11245	COG3182	Iron-regulated membrane protein
HPM96_11250	COG0668	transmembrane transport
HPM96_11255	COG4166	transmembrane transport
HPM96_11260	COG2866	Carboxypeptidase
HPM96_11265	COG4948	Mandelate Racemase Muconate Lactonizing
HPM96_11270	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
HPM96_11275	COG3283	Transcriptional regulator of aromatic amino acids metabolism
HPM96_11285	COG3106	COG3106 Predicted ATPase
HPM96_11290	COG1609	Transcriptional regulator
HPM96_11300	COG3842	ATPase activity
HPM96_11305	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HPM96_11310	COG1554	hydrolase, family 65, central catalytic
HPM96_11315	COG0673	inositol 2-dehydrogenase activity
HPM96_11320	COG1082	Xylose isomerase domain protein TIM barrel
HPM96_11325	COG1063	alcohol dehydrogenase
HPM96_11330	COG0395	ABC-type sugar transport system, permease component
HPM96_11335	COG1175	transmembrane transport
HPM96_11340	COG1653	transport
HPM96_11345	COG0366	Alpha amylase catalytic
HPM96_11350	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HPM96_11360	COG1983	PspC domain protein
HPM96_11370	COG1842	Phage shock protein A
HPM96_11375	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
HPM96_11380	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HPM96_11385	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HPM96_11390	COG1012	belongs to the aldehyde dehydrogenase family
HPM96_11395	COG1917	Cupin 2, conserved barrel domain protein
HPM96_11395	COG1396	sequence-specific DNA binding
HPM96_11400	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
HPM96_11405	COG0174	glutamine synthetase
HPM96_11415	COG0531	amino acid
HPM96_11425	COG4166	transmembrane transport
HPM96_11430	COG4168	peptide transport system, permease
HPM96_11435	COG4171	peptide transport system, permease
HPM96_11440	COG4172	Belongs to the ABC transporter superfamily
HPM96_11445	COG4172	Belongs to the ABC transporter superfamily
HPM96_11450	COG2814	Major facilitator Superfamily
HPM96_11460	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HPM96_11465	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HPM96_11475	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HPM96_11480	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HPM96_11480	COG4950	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HPM96_11495	COG5001	Diguanylate cyclase
HPM96_11505	COG1349	DNA-binding transcription factor activity
HPM96_11515	COG0023	Translation Initiation Factor
HPM96_11525	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
HPM96_11530	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
HPM96_11535	COG0671	phosphoesterase, PA-phosphatase related
HPM96_11545	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HPM96_11565	COG0583	DNA-binding transcription factor activity
HPM96_11570	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HPM96_11580	COG0616	signal peptide processing
HPM96_11585	COG1028	Short-chain dehydrogenase reductase Sdr
HPM96_11590	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
HPM96_11605	COG1187	pseudouridine synthase activity
HPM96_11610	COG4907	membrane protein (DUF2207)
HPM96_11615	COG0009	L-threonylcarbamoyladenylate synthase
HPM96_11620	COG0613	PHP domain protein
HPM96_11630	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HPM96_11635	COG0512	Glutamine amidotransferase of anthranilate synthase
HPM96_11635	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HPM96_11640	COG0135	phosphoribosylanthranilate isomerase activity
HPM96_11640	COG0134	indole-3-glycerol-phosphate synthase activity
HPM96_11655	COG3729	General stress protein
HPM96_11660	COG3685	Protein conserved in bacteria
HPM96_11665	COG3685	Protein conserved in bacteria
HPM96_11670	COG3047	cAMP biosynthetic process
HPM96_11690	COG1607	acyl-coa hydrolase
HPM96_11700	COG2350	Protein conserved in bacteria
HPM96_11705	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HPM96_11725	COG4608	Belongs to the ABC transporter superfamily
HPM96_11730	COG0444	Belongs to the ABC transporter superfamily
HPM96_11735	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HPM96_11740	COG0601	transmembrane transport
HPM96_11745	COG4166	transmembrane transport
HPM96_11755	COG2095	MarC family integral membrane protein
HPM96_11760	COG1012	belongs to the aldehyde dehydrogenase family
HPM96_11760	COG1454	alcohol dehydrogenase
HPM96_11765	COG3385	transposase activity
HPM96_11770	COG1435	thymidine kinase activity
HPM96_11780	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HPM96_11785	COG0745	RESPONSE REGULATOR receiver
HPM96_11790	COG1752	Esterase of the alpha-beta hydrolase superfamily
HPM96_11800	COG0788	formyltetrahydrofolate deformylase activity
HPM96_11830	COG2181	nitrate reductase activity
HPM96_11835	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
HPM96_11840	COG1140	nitrate reductase beta subunit
HPM96_11845	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
HPM96_11850	COG2223	nitrite transmembrane transporter activity
HPM96_11855	COG3850	Histidine kinase
HPM96_11860	COG2197	response regulator
HPM96_11865	COG4932	domain protein
HPM96_11870	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
HPM96_11875	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
HPM96_11880	COG4572	Cation transport regulator
HPM96_11885	COG0387	Pfam Sodium calcium exchanger
HPM96_11910	COG2912	Transglutaminase-like superfamily
HPM96_11915	COG3094	Invasion gene expression up-regulator, SirB
HPM96_11920	COG2890	protein-(glutamine-N5) methyltransferase activity
HPM96_11945	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HPM96_11950	COG0659	secondary active sulfate transmembrane transporter activity
HPM96_11965	COG0012	GTP binding
HPM96_11975	COG3284	Transcriptional regulator
HPM96_11980	COG2376	Dihydroxyacetone kinase
HPM96_11985	COG1461	Dihydroxyacetone kinase
HPM96_11990	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
HPM96_11990	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HPM96_11990	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HPM96_12015	COG1120	ATPase activity
HPM96_12020	COG0500	methyltransferase
HPM96_12025	COG0157	Belongs to the NadC ModD family
HPM96_12040	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
HPM96_12050	COG1619	proteins homologs of microcin C7 resistance protein MccF
HPM96_12070	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HPM96_12080	COG2719	SpoVR family
HPM96_12095	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
HPM96_12100	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HPM96_12105	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HPM96_12120	COG0179	Fumarylacetoacetate (FAA) hydrolase
HPM96_12145	COG2894	cell division
HPM96_12200	COG2200	EAL domain
HPM96_12225	COG2200	EAL domain
HPM96_12230	COG0789	Transcriptional regulator
HPM96_12235	COG5562	phage envelope protein
HPM96_12250	COG0538	isocitrate dehydrogenase activity
HPM96_12255	COG1187	pseudouridine synthase activity
HPM96_12275	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HPM96_12285	COG2205	protein histidine kinase activity
HPM96_12290	COG2850	peptidyl-arginine hydroxylation
HPM96_12300	COG3842	ATPase activity
HPM96_12310	COG1177	transmembrane transport
HPM96_12315	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HPM96_12325	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
HPM96_12330	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HPM96_12340	COG4591	ABC-type transport system involved in lipoprotein release permease component
HPM96_12350	COG4591	ABC-type transport system involved in lipoprotein release permease component
HPM96_12355	COG4763	Acyl-transferase
HPM96_12360	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HPM96_12365	COG1388	LysM domain
HPM96_12365	COG1376	ErfK ybiS ycfS ynhG family protein
HPM96_12375	COG1309	transcriptional regulator
HPM96_12380	COG3134	Outer membrane lipoprotein
HPM96_12385	COG1252	NADH dehydrogenase
HPM96_12405	COG3417	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)
HPM96_12410	COG5633	Lipoprotein
HPM96_12415	COG0537	adenosine 5'-monophosphoramidase activity
HPM96_12420	COG4773	Receptor
HPM96_12425	COG1263	PTS System
HPM96_12425	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HPM96_12430	COG0084	hydrolase, TatD family'
HPM96_12435	COG0470	DNA polymerase III
HPM96_12445	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HPM96_12450	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HPM96_12455	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HPM96_12465	COG1028	Short-chain dehydrogenase reductase Sdr
HPM96_12470	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HPM96_12490	COG1399	metal-binding, possibly nucleic acid-binding protein
HPM96_12495	COG0424	maF-like protein
HPM96_12500	COG0564	pseudouridine synthase activity
HPM96_12505	COG1530	ribonuclease E activity
HPM96_12520	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HPM96_12525	COG1256	bacterial-type flagellum assembly
HPM96_12530	COG3951	Flagellar rod assembly protein muramidase FlgJ
HPM96_12530	COG1705	Flagellar rod assembly protein muramidase FlgJ
HPM96_12545	COG4786	Flagellar basal body rod
HPM96_12550	COG4787	bacterial-type flagellum-dependent cell motility
HPM96_12555	COG1749	Flagellar hook protein flgE
HPM96_12560	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
HPM96_12565	COG1558	bacterial-type flagellum-dependent cell motility
HPM96_12570	COG1815	bacterial-type flagellum-dependent cell motility
HPM96_12575	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
HPM96_12580	COG2747	anti-sigma28 factor FlgM
HPM96_12585	COG3418	PFAM FlgN family protein
HPM96_12590	COG0728	peptidoglycan biosynthetic process
HPM96_12595	COG0673	inositol 2-dehydrogenase activity
HPM96_12605	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HPM96_12615	COG2999	glutathione oxidoreductase activity
HPM96_12640	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HPM96_12650	COG3038	cytochrome b561
HPM96_12655	COG2353	YceI-like domain
HPM96_12665	COG1560	Kdo2-lipid A biosynthetic process
HPM96_12680	COG5645	(Lipo)protein
HPM96_12685	COG2943	transferase activity, transferring hexosyl groups
HPM96_12700	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HPM96_12705	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
HPM96_12730	COG2197	response regulator
HPM96_12745	COG1462	curli production assembly transport component CsgG
HPM96_12755	COG3381	protein complex oligomerization
HPM96_12775	COG3706	GGDEF domain
HPM96_12780	COG0457	Tetratricopeptide repeat
HPM96_12785	COG0726	polysaccharide deacetylase
HPM96_12785	COG1649	PFAM Uncharacterised BCR, COG1649
HPM96_12790	COG1215	transferase activity, transferring glycosyl groups
HPM96_12795	COG3658	cytochrome
HPM96_12800	COG1702	phosphate starvation-inducible protein PhoH
HPM96_12820	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HPM96_12830	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HPM96_12830	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HPM96_12830	COG0506	proline dehydrogenase activity
HPM96_12835	COG1309	transcriptional regulator
HPM96_12845	COG1335	isochorismatase
HPM96_12870	COG2233	PERMEase
HPM96_12875	COG3729	General stress protein
HPM96_12915	COG0243	molybdopterin cofactor binding
HPM96_12920	COG3005	denitrification pathway
HPM96_12925	COG0745	RESPONSE REGULATOR receiver
HPM96_12930	COG1879	ABC-type sugar transport system periplasmic component
HPM96_12935	COG0784	Response regulator, receiver
HPM96_12935	COG2198	Histidine kinase
HPM96_12935	COG2205	protein histidine kinase activity
HPM96_12940	COG0348	domain, Protein
HPM96_12960	COG1278	Cold shock
HPM96_12965	COG1278	Cold shock
HPM96_12980	COG1294	oxidase, subunit
HPM96_12985	COG1271	oxidase subunit
HPM96_12990	COG1773	rubredoxin
HPM96_12995	COG1999	signal sequence binding
HPM96_13000	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
HPM96_13005	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
HPM96_13010	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
HPM96_13015	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
HPM96_13025	COG0670	Belongs to the BI1 family
HPM96_13030	COG2920	part of a sulfur-relay system
HPM96_13035	COG1254	Belongs to the acylphosphatase family
HPM96_13050	COG1832	CoA-binding protein
HPM96_13065	COG0210	DNA helicase
HPM96_13070	COG3304	Inner membrane component domain
HPM96_13075	COG1289	transmembrane transporter activity
HPM96_13080	COG3070	regulator of competence-specific genes
HPM96_13100	COG1067	ATP-dependent peptidase activity
HPM96_13110	COG3130	regulation of translation
HPM96_13115	COG3009	Protein conserved in bacteria
HPM96_13120	COG3008	intermembrane lipid transfer
HPM96_13120	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HPM96_13125	COG2995	paraquat-inducible protein a
HPM96_13130	COG0488	(ABC) transporter
HPM96_13140	COG0633	Ferredoxin
HPM96_13140	COG3217	Mosc domain protein beta barrel domain protein
HPM96_13155	COG3121	Chaperone
HPM96_13160	COG3539	Fimbrial protein
HPM96_13165	COG3539	Fimbrial protein
HPM96_13170	COG3539	Fimbrial protein
HPM96_13175	COG3188	usher protein
HPM96_13180	COG3121	Chaperone
HPM96_13185	COG3539	Fimbrial protein
HPM96_13190	COG0431	NADPH-dependent FMN reductase
HPM96_13195	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HPM96_13205	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HPM96_13210	COG1116	anion transmembrane transporter activity
HPM96_13215	COG0308	aminopeptidase N
HPM96_13230	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HPM96_13235	COG1448	Aminotransferase
HPM96_13240	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HPM96_13245	COG3108	Peptidase M15
HPM96_13250	COG2989	Protein conserved in bacteria
HPM96_13260	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
HPM96_13270	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HPM96_13275	COG1434	Gram-negative-bacterium-type cell wall biogenesis
HPM96_13280	COG3173	Aminoglycoside phosphotransferase
HPM96_13295	COG3214	Protein conserved in bacteria
HPM96_13305	COG1132	(ABC) transporter
HPM96_13310	COG0658	competence protein
HPM96_13310	COG2333	competence protein COMEC
HPM96_13320	COG0539	negative regulation of cytoplasmic translation
HPM96_13330	COG0501	Belongs to the peptidase M48B family
HPM96_13345	COG2323	membrane
HPM96_13350	COG1944	ATP diphosphatase activity
HPM96_13355	COG2116	formate transmembrane transporter activity
HPM96_13360	COG1882	Formate acetyltransferase
HPM96_13365	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HPM96_13370	COG2249	NAD(P)H dehydrogenase (quinone) activity
HPM96_13375	COG0583	DNA-binding transcription factor activity
HPM96_13380	COG0531	amino acid
HPM96_13390	COG1335	isochorismatase
HPM96_13395	COG3302	dmso reductase anchor subunit
HPM96_13400	COG0437	4 iron, 4 sulfur cluster binding
HPM96_13405	COG0243	molybdopterin cofactor binding
HPM96_13415	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HPM96_13430	COG1522	sequence-specific DNA binding
HPM96_13435	COG0492	ferredoxin-NADP+ reductase activity
HPM96_13440	COG4988	ABC transporter
HPM96_13445	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
HPM96_13465	COG0542	response to heat
HPM96_13475	COG1278	Cold shock
HPM96_13480	COG0577	efflux transmembrane transporter activity
HPM96_13480	COG1136	(ABC) transporter
HPM96_13485	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HPM96_13490	COG2990	Protein conserved in bacteria
HPM96_13495	COG3593	DNA synthesis involved in DNA repair
HPM96_13500	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HPM96_13510	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HPM96_13520	COG1346	cytolysis
HPM96_13530	COG2949	membrane
HPM96_13540	COG0493	'glutamate synthase
HPM96_13545	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
HPM96_13545	COG0167	dihydroorotate dehydrogenase activity
HPM96_13550	COG4211	Belongs to the binding-protein-dependent transport system permease family
HPM96_13560	COG1879	ABC-type sugar transport system periplasmic component
HPM96_13565	COG1609	Transcriptional regulator
HPM96_13570	COG2311	Membrane
HPM96_13590	COG1760	l-serine dehydratase
HPM96_13595	COG0560	Phosphoserine phosphatase
HPM96_13605	COG4771	TonB-dependent receptor
HPM96_13610	COG0833	amino acid
HPM96_13615	COG0583	DNA-binding transcription factor activity
HPM96_13620	COG2855	membrane
HPM96_13630	COG1522	sequence-specific DNA binding
HPM96_13630	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HPM96_13635	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HPM96_13645	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HPM96_13650	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HPM96_13655	COG2313	pseudouridylate synthase activity
HPM96_13660	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HPM96_13665	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
HPM96_13665	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HPM96_13665	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HPM96_13670	COG1105	Belongs to the carbohydrate kinase PfkB family
HPM96_13675	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HPM96_13675	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HPM96_13680	COG2814	Major facilitator Superfamily
HPM96_13695	COG0246	Mannitol dehydrogenase
HPM96_13700	COG0523	cobalamin synthesis protein
HPM96_13705	COG0671	phosphoesterase, PA-phosphatase related
HPM96_13710	COG0791	NLP P60 protein
HPM96_13715	COG2200	EAL domain
HPM96_13720	COG4166	transmembrane transport
HPM96_13725	COG4174	ABC transporter (Permease)
HPM96_13730	COG4239	(ABC) transporter, permease
HPM96_13735	COG4172	Belongs to the ABC transporter superfamily
HPM96_13745	COG2814	Major facilitator Superfamily
HPM96_13750	COG1187	pseudouridine synthase activity
HPM96_13755	COG1061	Type III restriction enzyme res subunit
HPM96_13775	COG3083	sulfuric ester hydrolase activity
HPM96_13785	COG3468	outer membrane autotransporter barrel domain protein
HPM96_13790	COG2197	response regulator
HPM96_13795	COG3088	subunit of a heme lyase
HPM96_13795	COG4235	cytochrome complex assembly
HPM96_13800	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HPM96_13805	COG1138	Cytochrome C-type biogenesis protein
HPM96_13815	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HPM96_13820	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HPM96_13825	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HPM96_13830	COG4133	protoheme IX ABC transporter activity
HPM96_13835	COG3005	denitrification pathway
HPM96_13840	COG3043	anaerobic respiration
HPM96_13845	COG0348	domain, Protein
HPM96_13850	COG0437	4 iron, 4 sulfur cluster binding
HPM96_13860	COG3062	negative regulation of establishment of protein localization
HPM96_13865	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
HPM96_13865	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HPM96_13885	COG4615	Cyclic peptide transporter
HPM96_13890	COG3145	DNA-N1-methyladenine dioxygenase activity
HPM96_13895	COG2169	Transcriptional regulator
HPM96_13895	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HPM96_13900	COG1477	protein flavinylation
HPM96_13905	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HPM96_13910	COG0642	Histidine kinase
HPM96_13910	COG2198	Histidine kinase
HPM96_13915	COG2197	response regulator
HPM96_13920	COG2205	protein histidine kinase activity
HPM96_13920	COG0784	Response regulator, receiver
HPM96_13925	COG3852	Histidine kinase
HPM96_13930	COG2204	response regulator
HPM96_13935	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HPM96_13940	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HPM96_13945	COG2031	fatty acid transporter
HPM96_13950	COG0183	Belongs to the thiolase family
HPM96_13955	COG4676	Protein conserved in bacteria
HPM96_13960	COG5445	Predicted secreted protein (DUF2300)
HPM96_13965	COG2373	Large extracellular alpha-helical protein
HPM96_13970	COG3234	Protein of unknown function (DUF1175)
HPM96_13975	COG4685	Uncharacterized protein conserved in bacteria (DUF2138)
HPM96_13980	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HPM96_13985	COG4948	Mandelate Racemase Muconate Lactonizing
HPM96_13995	COG1802	Transcriptional regulator
HPM96_14005	COG3468	outer membrane autotransporter barrel domain protein
HPM96_14010	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HPM96_14015	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HPM96_14020	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HPM96_14025	COG3642	lipopolysaccharide core region biosynthetic process
HPM96_14030	COG2814	Major facilitator Superfamily
HPM96_14035	COG0583	DNA-binding transcription factor activity
HPM96_14040	COG0584	glycerophosphoryl diester phosphodiesterase
HPM96_14045	COG2271	Major facilitator Superfamily
HPM96_14050	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HPM96_14060	COG0247	lactate metabolic process
HPM96_14065	COG5464	transposase or invertase
HPM96_14080	COG2271	Major facilitator Superfamily
HPM96_14090	COG1414	Transcriptional regulator
HPM96_14155	COG0318	PFAM AMP-dependent synthetase and ligase
HPM96_14165	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
HPM96_14180	COG1169	isochorismate synthase
HPM96_14185	COG4575	ribosome binding
HPM96_14190	COG2153	protein acetylation
HPM96_14220	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HPM96_14225	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HPM96_14235	COG0839	Belongs to the complex I subunit 6 family
HPM96_14250	COG1034	ATP synthesis coupled electron transport
HPM96_14255	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
HPM96_14260	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
HPM96_14280	COG0583	DNA-binding transcription factor activity
HPM96_14285	COG0436	Aminotransferase
HPM96_14295	COG0490	domain, Protein
HPM96_14295	COG0471	metal ion transport
HPM96_14300	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HPM96_14315	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HPM96_14320	COG0857	belongs to the CobB CobQ family
HPM96_14320	COG0280	phosphate acetyltransferase
HPM96_14325	COG1288	antiporter activity
HPM96_14330	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
HPM96_14335	COG0622	Phosphoesterase
HPM96_14340	COG0625	glutathione transferase activity
HPM96_14345	COG0625	glutathione transferase activity
HPM96_14350	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HPM96_14355	COG1090	epimerase
HPM96_14360	COG1757	Na H antiporter
HPM96_14365	COG0626	cystathionine gamma-synthase activity
HPM96_14370	COG5464	transposase or invertase
HPM96_14375	COG4598	ABC transporter
HPM96_14380	COG4160	amino acid transport
HPM96_14385	COG4215	(ABC) transporter
HPM96_14390	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HPM96_14395	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HPM96_14400	COG0163	prenyltransferase activity
HPM96_14405	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HPM96_14410	COG1286	toxin biosynthetic process
HPM96_14415	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
HPM96_14420	COG0285	dihydrofolate synthase activity
HPM96_14430	COG0586	Pfam SNARE associated Golgi protein
HPM96_14440	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HPM96_14455	COG2814	Major facilitator Superfamily
HPM96_14460	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HPM96_14475	COG3101	peptidyl-lysine hydroxylation
HPM96_14480	COG0730	response to heat
HPM96_14495	COG2890	protein-(glutamine-N5) methyltransferase activity
HPM96_14520	COG3539	Fimbrial protein
HPM96_14525	COG3539	Fimbrial protein
HPM96_14530	COG3539	Fimbrial protein
HPM96_14535	COG3121	Chaperone
HPM96_14540	COG3188	usher protein
HPM96_14545	COG3539	Fimbrial protein
HPM96_14550	COG2062	phosphohistidine phosphatase, SixA
HPM96_14565	COG3691	Protein conserved in bacteria
HPM96_14570	COG2067	long-chain fatty acid transport protein
HPM96_14580	COG2853	Lipoprotein
HPM96_14585	COG2116	formate transmembrane transporter activity
HPM96_14595	COG0582	viral genome integration into host DNA
HPM96_14690	COG1783	phage Terminase large subunit
HPM96_14715	COG3772	lysozyme
HPM96_14895	COG0582	viral genome integration into host DNA
HPM96_14920	COG1201	RNA secondary structure unwinding
HPM96_14955	COG2271	Major facilitator Superfamily
HPM96_14960	COG1063	alcohol dehydrogenase
HPM96_15010	COG2186	Transcriptional regulator
HPM96_15050	COG0582	viral genome integration into host DNA
HPM96_15055	COG0582	viral genome integration into host DNA
HPM96_15060	COG0583	DNA-binding transcription factor activity
HPM96_15065	COG2610	gluconate transmembrane transporter activity
HPM96_15075	COG0477	Major facilitator Superfamily
HPM96_15080	COG1566	PFAM secretion protein HlyD family protein
HPM96_15085	COG2197	response regulator
HPM96_15090	COG0784	Response regulator, receiver
HPM96_15090	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HPM96_15090	COG2198	Histidine kinase
HPM96_15090	COG2205	protein histidine kinase activity
HPM96_15095	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HPM96_15100	COG0679	Auxin Efflux Carrier
HPM96_15105	COG0028	Belongs to the TPP enzyme family
HPM96_15130	COG1560	Kdo2-lipid A biosynthetic process
HPM96_15140	COG0436	Aminotransferase
HPM96_15145	COG3275	phosphorelay sensor kinase activity
HPM96_15150	COG3279	Response regulator of the LytR AlgR family
HPM96_15155	COG2207	Transcriptional regulator
HPM96_15165	COG1363	Peptidase, m42
HPM96_15170	COG0006	proline dipeptidase activity
HPM96_15175	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HPM96_15180	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HPM96_15205	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HPM96_15210	COG2200	EAL domain
HPM96_15210	COG2199	diguanylate cyclase activity
HPM96_15225	COG3415	Transposase
HPM96_15230	COG3415	Transposase
HPM96_15270	COG0583	DNA-binding transcription factor activity
HPM96_15280	COG2211	Major facilitator Superfamily
HPM96_15285	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
HPM96_15295	COG0583	DNA-binding transcription factor activity
HPM96_15300	COG0385	Bile acid
HPM96_15305	COG3530	Putative quorum-sensing-regulated virulence factor
HPM96_15325	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HPM96_15330	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HPM96_15335	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HPM96_15340	COG2190	(PTS) system
HPM96_15355	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HPM96_15360	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
HPM96_15365	COG4208	sulfate ABC transporter
HPM96_15370	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
HPM96_15375	COG4150	thiosulfate binding
HPM96_15380	COG1028	Short-chain dehydrogenase reductase Sdr
HPM96_15395	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HPM96_15395	COG1263	PTS System
HPM96_15400	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HPM96_15405	COG2837	iron assimilation
HPM96_15425	COG0860	N-Acetylmuramoyl-L-alanine amidase
HPM96_15435	COG2207	Transcriptional regulator
HPM96_15440	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
HPM96_15445	COG4816	utilization protein
HPM96_15455	COG4303	Ethanolamine ammonia lyase large subunit
HPM96_15460	COG4819	ethanolamine utilization protein
HPM96_15465	COG3192	ethanolamine utilization protein
HPM96_15470	COG1454	alcohol dehydrogenase
HPM96_15475	COG4820	ethanolamine utilization protein (EutJ)
HPM96_15480	COG1012	belongs to the aldehyde dehydrogenase family
HPM96_15485	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
HPM96_15490	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
HPM96_15495	COG0280	phosphate acetyltransferase
HPM96_15500	COG4812	Cobalamin adenosyltransferase
HPM96_15505	COG4766	ethanolamine catabolic process
HPM96_15510	COG4917	ethanolamine utilization protein
HPM96_15515	COG4810	utilization protein
HPM96_15520	COG0281	malic enzyme
HPM96_15520	COG0280	phosphate acetyltransferase
HPM96_15525	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HPM96_15530	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HPM96_15535	COG5342	invasion associated locus B
HPM96_15545	COG0493	'glutamate synthase
HPM96_15545	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HPM96_15550	COG3850	Histidine kinase
HPM96_15555	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HPM96_15565	COG1393	Belongs to the ArsC family
HPM96_15580	COG0400	carboxylic ester hydrolase activity
HPM96_15590	COG2321	neutral zinc metallopeptidase
HPM96_15600	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
HPM96_15610	COG2716	regulation of RNA biosynthetic process
HPM96_15615	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HPM96_15620	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HPM96_15625	COG0651	ATP synthesis coupled electron transport
HPM96_15630	COG0650	Formate hydrogenlyase subunit 4
HPM96_15635	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HPM96_15640	COG4237	Hydrogenase 4 membrane
HPM96_15645	COG0651	ATP synthesis coupled electron transport
HPM96_15650	COG3261	NADH dehydrogenase
HPM96_15650	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
HPM96_15655	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HPM96_15660	COG3260	NADH ubiquinone oxidoreductase 20
HPM96_15670	COG3604	Transcriptional regulator
HPM96_15675	COG2116	formate transmembrane transporter activity
HPM96_15680	COG0628	permease
HPM96_15685	COG4783	chaperone-mediated protein folding
HPM96_15690	COG1393	Belongs to the ArsC family
HPM96_15700	COG2233	PERMEase
HPM96_15715	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HPM96_15720	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
HPM96_15725	COG0248	Ppx GppA phosphatase
HPM96_15730	COG2200	EAL domain
HPM96_15745	COG3133	Outer membrane lipoprotein
HPM96_15760	COG3179	chitinase
HPM96_15895	COG3728	DNA packaging
HPM96_15895	COG5484	DNA packaging
HPM96_15970	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HPM96_16010	COG0516	GMP reductase activity
HPM96_16010	COG0517	IMP dehydrogenase activity
HPM96_16035	COG1645	bacterial-type flagellum-dependent swarming motility
HPM96_16050	COG2976	Protein conserved in bacteria
HPM96_16080	COG4953	penicillin-binding protein 1C
HPM96_16085	COG2373	Large extracellular alpha-helical protein
HPM96_16090	COG2897	thiosulfate sulfurtransferase activity
HPM96_16105	COG2975	iron-sulfur cluster assembly
HPM96_16110	COG0633	Ferredoxin
HPM96_16130	COG0822	iron-sulfur transferase activity
HPM96_16150	COG0483	inositol monophosphate 1-phosphatase activity
HPM96_16155	COG1073	alpha beta
HPM96_16160	COG3711	transcriptional antiterminator
HPM96_16165	COG2814	Major facilitator Superfamily
HPM96_16170	COG0583	DNA-binding transcription factor activity
HPM96_16175	COG4638	Rieske (2fe-2S)
HPM96_16200	COG2259	Doxx family
HPM96_16205	COG2017	converts alpha-aldose to the beta-anomer
HPM96_16210	COG1063	alcohol dehydrogenase
HPM96_16215	COG1172	Belongs to the binding-protein-dependent transport system permease family
HPM96_16220	COG1129	ABC transporter
HPM96_16225	COG1879	ABC-type sugar transport system periplasmic component
HPM96_16230	COG0457	Tetratricopeptide repeat
HPM96_16235	COG1940	carbohydrate kinase activity
HPM96_16245	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HPM96_16245	COG1017	nitric oxide dioxygenase activity
HPM96_16250	COG0347	Belongs to the P(II) protein family
HPM96_16255	COG2204	response regulator
HPM96_16260	COG3170	Tfp pilus assembly protein FimV
HPM96_16265	COG2205	protein histidine kinase activity
HPM96_16270	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HPM96_16270	COG0047	phosphoribosylformylglycinamidine synthase activity
HPM96_16280	COG0590	tRNA wobble adenosine to inosine editing
HPM96_16285	COG0560	Phosphoserine phosphatase
HPM96_16290	COG1737	Transcriptional regulator
HPM96_16295	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HPM96_16310	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
HPM96_16330	COG0681	Belongs to the peptidase S26 family
HPM96_16340	COG3086	response to oxidative stress
HPM96_16345	COG3026	antisigma factor binding
HPM96_16350	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
HPM96_16355	COG1595	DNA-templated transcription, initiation
HPM96_16365	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HPM96_16375	COG0513	Belongs to the DEAD box helicase family
HPM96_16380	COG0583	DNA-binding transcription factor activity
HPM96_16400	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HPM96_16405	COG3118	belongs to the thioredoxin family
HPM96_16415	COG0045	succinate-CoA ligase (ADP-forming) activity
HPM96_16415	COG1042	CoA-binding domain protein
HPM96_16415	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HPM96_16420	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HPM96_16425	COG5544	Lipoprotein
HPM96_16430	COG0477	Major facilitator Superfamily
HPM96_16455	COG0542	response to heat
HPM96_16465	COG0564	pseudouridine synthase activity
HPM96_16470	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HPM96_16475	COG3385	transposase activity
HPM96_16480	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HPM96_16490	COG1605	Chorismate mutase
HPM96_16490	COG0077	Prephenate dehydratase
HPM96_16495	COG1605	Chorismate mutase
HPM96_16495	COG0287	Prephenate dehydrogenase
HPM96_16500	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HPM96_16515	COG2199	diguanylate cyclase activity
HPM96_16520	COG2885	chlorophyll binding
HPM96_16545	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HPM96_16550	COG4137	Cytochrome C assembly protein
HPM96_16555	COG4536	flavin adenine dinucleotide binding
HPM96_16570	COG0497	DNA recombination
HPM96_16575	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HPM96_16585	COG2867	negative regulation of translational initiation
HPM96_16600	COG3468	outer membrane autotransporter barrel domain protein
HPM96_16635	COG0579	oxidoreductase
HPM96_16640	COG1012	belongs to the aldehyde dehydrogenase family
HPM96_16645	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HPM96_16650	COG1113	amino acid transport
HPM96_16655	COG1802	Transcriptional regulator
HPM96_16660	COG1652	LysM domain
HPM96_16665	COG0401	homolog of Blt101
HPM96_16670	COG0640	Transcriptional regulator
HPM96_16675	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HPM96_16680	COG2916	Histone family protein nucleoid-structuring protein H-NS
HPM96_16695	COG4575	ribosome binding
HPM96_16700	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HPM96_16705	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HPM96_16710	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HPM96_16720	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HPM96_16725	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HPM96_16730	COG4175	Glycine betaine
HPM96_16735	COG4176	ABC-type proline glycine betaine transport system permease component
HPM96_16740	COG2113	Glycine betaine
HPM96_16745	COG2814	Major facilitator Superfamily
HPM96_16750	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
HPM96_16760	COG1846	Transcriptional regulator
HPM96_16765	COG1566	PFAM secretion protein HlyD family protein
HPM96_16770	COG2814	Major facilitator Superfamily
HPM96_16785	COG1238	metal cluster binding
HPM96_16790	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HPM96_16820	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
HPM96_16840	COG1546	Belongs to the CinA family
HPM96_16845	COG2951	lytic endotransglycosylase activity
HPM96_16850	COG3730	PTS system glucitol sorbitol-specific
HPM96_16855	COG3732	PTS system glucitol sorbitol-specific
HPM96_16865	COG1028	Short-chain dehydrogenase reductase Sdr
HPM96_16870	COG4578	phosphoenolpyruvate-dependent sugar phosphotransferase system
HPM96_16875	COG1349	DNA-binding transcription factor activity
HPM96_16900	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
HPM96_16905	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HPM96_16910	COG1609	Transcriptional regulator
HPM96_16915	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HPM96_16915	COG1263	PTS System
HPM96_16920	COG2723	6-phospho-beta-galactosidase activity
HPM96_16930	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
HPM96_16940	COG3260	NADH ubiquinone oxidoreductase 20
HPM96_16945	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HPM96_16950	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
HPM96_16950	COG3261	NADH dehydrogenase
HPM96_16955	COG0650	Formate hydrogenlyase subunit 4
HPM96_16960	COG0651	ATP synthesis coupled electron transport
HPM96_16965	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HPM96_16975	COG0375	protein maturation
HPM96_16980	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
HPM96_16985	COG0298	carbon dioxide binding
HPM96_16990	COG0409	Hydrogenase expression formation protein
HPM96_16995	COG0309	Hydrogenase expression formation protein (HypE)
HPM96_17000	COG3604	Transcriptional regulator
HPM96_17025	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HPM96_17035	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HPM96_17040	COG0163	prenyltransferase activity
HPM96_17050	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HPM96_17055	COG4942	peptidase
HPM96_17055	COG1388	LysM domain
HPM96_17110	COG2234	aminopeptidase activity
HPM96_17135	COG0720	synthase
HPM96_17140	COG0644	oxidoreductase
HPM96_17145	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
HPM96_17150	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
HPM96_17155	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
HPM96_17160	COG2086	electron transfer activity
HPM96_17165	COG0477	Major facilitator Superfamily
HPM96_17170	COG0277	FAD linked oxidase domain protein
HPM96_17175	COG1028	Short-chain dehydrogenase reductase Sdr
HPM96_17180	COG2223	nitrite transmembrane transporter activity
HPM96_17185	COG1070	Carbohydrate kinase
HPM96_17215	COG0602	queuosine metabolic process
HPM96_17225	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
HPM96_17235	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
HPM96_17250	COG3956	TIGRFAM MazG family protein
HPM96_17255	COG2337	Toxic component of a toxin-antitoxin (TA) module
HPM96_17260	COG2336	PFAM SpoVT AbrB
HPM96_17265	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HPM96_17275	COG4999	Histidine kinase
HPM96_17275	COG3437	response regulator, receiver
HPM96_17275	COG2205	protein histidine kinase activity
HPM96_17275	COG3850	Histidine kinase
HPM96_17280	COG4948	Mandelate Racemase Muconate Lactonizing
HPM96_17285	COG4948	Mandelate Racemase Muconate Lactonizing
HPM96_17290	COG2271	Major facilitator Superfamily
HPM96_17295	COG0716	FMN binding
HPM96_17300	COG0564	pseudouridine synthase activity
HPM96_17305	COG3098	single-species biofilm formation
HPM96_17320	COG1611	Belongs to the LOG family
HPM96_17325	COG0814	amino acid
HPM96_17330	COG1760	l-serine dehydratase
HPM96_17340	COG1454	alcohol dehydrogenase
HPM96_17345	COG0235	Class ii aldolase
HPM96_17350	COG0738	Major facilitator superfamily
HPM96_17360	COG1070	Carbohydrate kinase
HPM96_17370	COG1349	DNA-binding transcription factor activity
HPM96_17380	COG2363	Small membrane protein
HPM96_17385	COG0583	DNA-binding transcription factor activity
HPM96_17395	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HPM96_17400	COG2166	iron-sulfur cluster assembly
HPM96_17405	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HPM96_17410	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
HPM96_17440	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HPM96_17445	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HPM96_17445	COG1263	PTS System
HPM96_17450	COG3711	transcriptional antiterminator
HPM96_17455	COG0860	N-Acetylmuramoyl-L-alanine amidase
HPM96_17460	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
HPM96_17460	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HPM96_17465	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HPM96_17470	COG1074	ATP-dependent DNA helicase activity
HPM96_17475	COG1025	Belongs to the peptidase M16 family
HPM96_17480	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
HPM96_17485	COG4967	type IV pilus modification protein PilV
HPM96_17495	COG4795	General secretion pathway protein
HPM96_17500	COG2165	general secretion pathway protein
HPM96_17515	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
HPM96_17530	COG0861	Integral membrane protein TerC family
HPM96_17540	COG0667	Aldo Keto reductase
HPM96_17555	COG1609	Transcriptional regulator
HPM96_17565	COG0583	DNA-binding transcription factor activity
HPM96_17570	COG1794	racemase activity, acting on amino acids and derivatives
HPM96_17575	COG2814	Major facilitator Superfamily
HPM96_17580	COG1028	Short-chain dehydrogenase reductase Sdr
HPM96_17590	COG0183	Belongs to the thiolase family
HPM96_17595	COG0814	amino acid
HPM96_17605	COG4942	peptidase
HPM96_17610	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HPM96_17615	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
HPM96_17620	COG2080	2 iron, 2 sulfur cluster binding
HPM96_17630	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HPM96_17635	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HPM96_17640	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HPM96_17650	COG0549	Belongs to the carbamate kinase family
HPM96_17655	COG3608	succinylglutamate desuccinylase aspartoacylase
HPM96_17655	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
HPM96_17660	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HPM96_17665	COG2068	MobA-Related Protein
HPM96_17670	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HPM96_17670	COG0493	'glutamate synthase
HPM96_17675	COG0402	S-adenosylhomocysteine deaminase activity
HPM96_17680	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
HPM96_17685	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HPM96_17685	COG2080	2 iron, 2 sulfur cluster binding
HPM96_17690	COG2233	PERMEase
HPM96_17695	COG0402	S-adenosylhomocysteine deaminase activity
HPM96_17700	COG2252	PERMEase
HPM96_17705	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HPM96_17715	COG2233	PERMEase
HPM96_17730	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HPM96_17740	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HPM96_17745	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HPM96_17750	COG4974	Belongs to the 'phage' integrase family
HPM96_17755	COG0716	FMN binding
HPM96_17765	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
HPM96_17775	COG1272	protein, Hemolysin III
HPM96_17785	COG2723	6-phospho-beta-galactosidase activity
HPM96_17810	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HPM96_17815	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HPM96_17820	COG0006	proline dipeptidase activity
HPM96_17840	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HPM96_17850	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HPM96_17865	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HPM96_17865	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HPM96_17870	COG1703	isobutyryl-CoA mutase activity
HPM96_17875	COG1024	Enoyl-CoA hydratase
HPM96_17880	COG0427	acetyl-CoA hydrolase
HPM96_17885	COG0583	DNA-binding transcription factor activity
HPM96_17890	COG2968	Membrane
HPM96_17895	COG1279	arginine transmembrane transporter activity
HPM96_17900	COG0668	transmembrane transport
HPM96_17905	COG0191	fructose-bisphosphate aldolase activity
HPM96_17940	COG1122	ATPase activity
HPM96_17945	COG1072	(Pantothenic acid kinase))
HPM96_17955	COG1494	fructose-1,6-bisphosphatase
HPM96_17960	COG1063	alcohol dehydrogenase
HPM96_17965	COG2213	PTS system mannitol-specific
HPM96_17970	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HPM96_17975	COG0330	HflC and HflK could
HPM96_17980	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HPM96_17985	COG0501	Belongs to the peptidase M48B family
HPM96_18000	COG3716	PTS system mannose fructose sorbose family IID component
HPM96_18005	COG3715	PTS system
HPM96_18010	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HPM96_18010	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HPM96_18035	COG1166	arginine decarboxylase activity
HPM96_18055	COG2814	Major facilitator Superfamily
HPM96_18065	COG2356	endonuclease I
HPM96_18070	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HPM96_18075	COG0189	ligase activity
HPM96_18090	COG2805	Type II/IV secretion system protein
HPM96_18095	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HPM96_18100	COG0762	integral membrane protein
HPM96_18110	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HPM96_18115	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HPM96_18120	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HPM96_18125	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
HPM96_18140	COG0252	asparaginase activity
HPM96_18150	COG3171	Protein conserved in bacteria
HPM96_18160	COG1194	a g-specific adenine glycosylase
HPM96_18175	COG2211	Major facilitator Superfamily
HPM96_18180	COG1982	Orn Lys Arg decarboxylase major
HPM96_18185	COG1811	Na channel or pump
HPM96_18195	COG0582	viral genome integration into host DNA
HPM96_18240	COG2194	sulfuric ester hydrolase activity
HPM96_18285	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HPM96_18300	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
HPM96_18340	COG2235	arginine
HPM96_18355	COG1288	antiporter activity
HPM96_18360	COG1438	arginine binding
HPM96_18445	COG3596	GTP binding
HPM96_18470	COG2003	Belongs to the UPF0758 family
HPM96_18505	COG3609	addiction module antidote protein, CC2985 family
HPM96_18550	COG1215	transferase activity, transferring glycosyl groups
HPM96_18560	COG0110	maltose O-acetyltransferase activity
HPM96_18565	COG0562	UDP-galactopyranose mutase
HPM96_18570	COG1216	Glycosyl transferase, family 2
HPM96_18595	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
HPM96_18610	COG4795	General secretion pathway protein
HPM96_18625	COG2165	general secretion pathway protein
HPM96_18630	COG1459	type II secretion system
HPM96_18635	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HPM96_18660	COG3064	Membrane
HPM96_18665	COG1620	l-lactate permease
HPM96_18670	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
HPM96_18675	COG3193	protein, possibly involved in utilization of glycolate and propanediol
HPM96_18680	COG0247	lactate metabolic process
HPM96_18685	COG0277	FAD linked oxidase domain protein
HPM96_18690	COG0277	FAD linked oxidase domain protein
HPM96_18695	COG2186	Transcriptional regulator
HPM96_18700	COG0456	acetyltransferase
HPM96_18705	COG0318	PFAM AMP-dependent synthetase and ligase
HPM96_18715	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HPM96_18720	COG0156	8-amino-7-oxononanoate synthase activity
HPM96_18730	COG0795	lipopolysaccharide-transporting ATPase activity
HPM96_18735	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
HPM96_18745	COG2244	polysaccharide biosynthetic process
HPM96_18750	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HPM96_18755	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HPM96_18760	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HPM96_18765	COG0306	phosphate transporter
HPM96_18770	COG0754	glutathionylspermidine amidase activity
HPM96_18775	COG0625	glutathione transferase activity
HPM96_18780	COG0298	carbon dioxide binding
HPM96_18790	COG1773	rubredoxin
HPM96_18795	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
HPM96_18800	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
HPM96_18805	COG5557	Pfam Polysulphide reductase, NrfD
HPM96_18810	COG0437	4 iron, 4 sulfur cluster binding
HPM96_18815	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
HPM96_18830	COG0667	Aldo Keto reductase
HPM96_18840	COG1028	Short-chain dehydrogenase reductase Sdr
HPM96_18845	COG0848	biopolymer transport protein
HPM96_18850	COG0811	peptide transport
HPM96_18855	COG0626	cystathionine gamma-synthase activity
HPM96_18860	COG0586	Pfam SNARE associated Golgi protein
HPM96_18865	COG2207	Transcriptional regulator
HPM96_18870	COG1979	alcohol dehydrogenase
HPM96_18875	COG0656	L-ascorbic acid biosynthetic process
HPM96_18885	COG4238	major outer membrane lipoprotein
HPM96_18900	COG1032	radical SAM domain protein
HPM96_18905	COG2186	Transcriptional regulator
HPM96_18910	COG0246	Mannitol dehydrogenase
HPM96_18915	COG1063	alcohol dehydrogenase
HPM96_18920	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
HPM96_18940	COG2132	Multicopper oxidase
HPM96_18945	COG0204	Acyl-transferase
HPM96_18950	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HPM96_18955	COG4166	transmembrane transport
HPM96_18960	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
HPM96_18965	COG3111	PFAM Bacterial OB fold (BOF) protein
HPM96_18970	COG0745	RESPONSE REGULATOR receiver
HPM96_18975	COG0642	Histidine kinase
HPM96_18980	COG2249	NAD(P)H dehydrogenase (quinone) activity
HPM96_18985	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
HPM96_18990	COG1737	Transcriptional regulator
HPM96_19000	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HPM96_19005	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HPM96_19010	COG1120	ATPase activity
HPM96_19015	COG4774	siderophore transport
HPM96_19020	COG0187	DNA topoisomerase II activity
HPM96_19025	COG3150	esterase
HPM96_19030	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HPM96_19035	COG3151	Protein conserved in bacteria
HPM96_19040	COG0494	nUDIX hydrolase
HPM96_19045	COG1538	Outer membrane efflux protein
HPM96_19055	COG0754	glutathionylspermidine amidase activity
HPM96_19065	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
HPM96_19075	COG3384	dioxygenase
HPM96_19105	COG1585	Membrane protein implicated in regulation of membrane protease activity
HPM96_19110	COG2268	Band 7 protein
HPM96_19130	COG3025	triphosphatase activity
HPM96_19135	COG4991	sh3 domain protein
HPM96_19150	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HPM96_19165	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
HPM96_19170	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HPM96_19185	COG0828	Belongs to the bacterial ribosomal protein bS21 family
HPM96_19190	COG0358	DNA primase activity
HPM96_19195	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HPM96_19210	COG2375	cellular response to nickel ion
HPM96_19215	COG1695	Transcriptional regulator
HPM96_19220	COG0840	transmembrane signaling receptor activity
HPM96_19230	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HPM96_19235	COG1609	Transcriptional regulator
HPM96_19240	COG3250	beta-galactosidase activity
HPM96_19245	COG2731	YhcH YjgK YiaL family protein
HPM96_19250	COG0531	amino acid
HPM96_19260	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
HPM96_19260	COG3408	Glycogen debranching enzyme
HPM96_19265	COG0446	pyridine nucleotide-disulphide oxidoreductase
HPM96_19265	COG1902	pentaerythritol trinitrate reductase activity
HPM96_19275	COG1451	nucleotide metabolic process
HPM96_19280	COG2949	membrane
HPM96_19285	COG0673	inositol 2-dehydrogenase activity
HPM96_19290	COG0861	Integral membrane protein TerC family
HPM96_19295	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
HPM96_19305	COG2721	sulfolactate sulfo-lyase activity
HPM96_19315	COG2271	Major facilitator Superfamily
HPM96_19340	COG2186	Transcriptional regulator
HPM96_19345	COG0586	Pfam SNARE associated Golgi protein
HPM96_19355	COG1422	Protein of unknown function (DUF1090)
HPM96_19360	COG4575	ribosome binding
HPM96_19365	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
HPM96_19375	COG2259	Doxx family
HPM96_19380	COG0435	Glutathione S-transferase
HPM96_19385	COG3152	Membrane
HPM96_19390	COG3152	Membrane
HPM96_19395	COG0583	DNA-binding transcription factor activity
HPM96_19400	COG1741	Belongs to the pirin family
HPM96_19415	COG0814	amino acid
HPM96_19420	COG1760	l-serine dehydratase
HPM96_19425	COG0251	oxidation-reduction process
HPM96_19430	COG1882	Formate acetyltransferase
HPM96_19435	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HPM96_19445	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HPM96_19450	COG0583	DNA-binding transcription factor activity
HPM96_19475	COG1929	Belongs to the glycerate kinase type-1 family
HPM96_19480	COG2084	Dehydrogenase
HPM96_19490	COG2271	Major facilitator Superfamily
HPM96_19495	COG2721	sulfolactate sulfo-lyase activity
HPM96_19500	COG2002	toxin-antitoxin pair type II binding
HPM96_19510	COG1349	DNA-binding transcription factor activity
HPM96_19520	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HPM96_19530	COG3716	PTS system mannose fructose sorbose family IID component
HPM96_19535	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HPM96_19540	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HPM96_19545	COG2222	sugar isomerase
HPM96_19555	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HPM96_19560	COG3715	PTS system
HPM96_19565	COG3716	PTS system mannose fructose sorbose family IID component
HPM96_19570	COG0363	glucosamine-6-phosphate deaminase activity
HPM96_19575	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HPM96_19595	COG2823	Periplasmic or secreted lipoprotein
HPM96_19600	COG0701	Predicted permease
HPM96_19605	COG0702	epimerase
HPM96_19610	COG0693	protein deglycase activity
HPM96_19625	COG3153	acetyltransferase
HPM96_19630	COG3154	lipid carrier protein
HPM96_19635	COG0826	peptidase U32
HPM96_19640	COG0826	peptidase U32
HPM96_19645	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HPM96_19650	COG0814	amino acid
HPM96_19655	COG0513	Belongs to the DEAD box helicase family
HPM96_19695	COG0195	Participates in both transcription termination and antitermination
HPM96_19715	COG2194	sulfuric ester hydrolase activity
HPM96_19725	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HPM96_19735	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HPM96_19740	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HPM96_19750	COG1534	Rna-binding protein
HPM96_19755	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HPM96_19760	COG2027	D-alanyl-D-alanine carboxypeptidase
HPM96_19770	COG0697	spore germination
HPM96_19785	COG0142	geranyltranstransferase activity
HPM96_19790	COG3423	Transcriptional regulator
HPM96_19800	COG5007	Belongs to the BolA IbaG family
HPM96_19805	COG3113	response to antibiotic
HPM96_19810	COG2854	intermembrane phospholipid transfer
HPM96_19815	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HPM96_19820	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HPM96_19825	COG1127	ABC transporter
HPM96_19830	COG0530	calcium, potassium:sodium antiporter activity
HPM96_19835	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HPM96_19835	COG0517	IMP dehydrogenase activity
HPM96_19840	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
HPM96_19845	COG3117	lipopolysaccharide transmembrane transporter activity
HPM96_19850	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
HPM96_19855	COG1137	ATPase activity
HPM96_19860	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
HPM96_19865	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HPM96_19880	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HPM96_19885	COG0515	serine threonine protein kinase
HPM96_19895	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
HPM96_19900	COG0784	Response regulator, receiver
HPM96_19900	COG2198	Histidine kinase
HPM96_19900	COG5002	protein histidine kinase activity
HPM96_19905	COG1242	4 iron, 4 sulfur cluster binding
HPM96_19910	COG0070	glutamate synthase
HPM96_19910	COG0067	glutamate synthase
HPM96_19910	COG0069	glutamate synthase activity
HPM96_19915	COG0493	'glutamate synthase
HPM96_19920	COG4804	nuclease activity
HPM96_19925	COG2731	YhcH YjgK YiaL family protein
HPM96_19955	COG3069	C4-dicarboxylate transmembrane transporter activity
HPM96_19960	COG2969	positive regulation of protein catabolic process
HPM96_19965	COG0625	glutathione transferase activity
HPM96_19985	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
HPM96_19990	COG3105	Protein conserved in bacteria
HPM96_19995	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HPM96_20000	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HPM96_20020	COG2732	(Barnase) inhibitor
HPM96_20040	COG0583	DNA-binding transcription factor activity
HPM96_20045	COG0312	modulator of DNA gyrase
HPM96_20050	COG3164	Protein of unknown function
HPM96_20055	COG1530	ribonuclease E activity
HPM96_20065	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
HPM96_20070	COG1792	Involved in formation and maintenance of cell shape
HPM96_20075	COG1077	Cell shape determining protein MreB Mrl
HPM96_20080	COG2199	diguanylate cyclase activity
HPM96_20080	COG2200	EAL domain
HPM96_20085	COG0604	alcohol dehydrogenase
HPM96_20090	COG0511	ligase activity, forming carbon-carbon bonds
HPM96_20095	COG0439	Biotin carboxylase
HPM96_20105	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HPM96_20110	COG1172	Belongs to the binding-protein-dependent transport system permease family
HPM96_20115	COG1129	ABC transporter
HPM96_20120	COG1879	ABC-type sugar transport system periplasmic component
HPM96_20130	COG1349	DNA-binding transcription factor activity
HPM96_20135	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HPM96_20140	COG3924	membrane
HPM96_20145	COG4145	pantothenate transmembrane transporter activity
HPM96_20155	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HPM96_20165	COG2189	Belongs to the N(4) N(6)-methyltransferase family
HPM96_20175	COG1309	transcriptional regulator
HPM96_20180	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HPM96_20185	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HPM96_20195	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HPM96_20200	COG4597	amino acid ABC transporter
HPM96_20205	COG0765	amino acid transport
HPM96_20210	COG1126	abc transporter atp-binding protein
HPM96_20250	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HPM96_20270	COG0551	DNA topoisomerase type I activity
HPM96_20280	COG0758	DNA mediated transformation
HPM96_20300	COG0569	domain protein
HPM96_20310	COG3036	rescue of stalled ribosome
HPM96_20315	COG0789	Transcriptional regulator
HPM96_20355	COG0201	protein transport
HPM96_20445	COG0089	rRNA binding
HPM96_20515	COG2964	Protein conserved in bacteria
HPM96_20520	COG0545	Peptidyl-prolyl cis-trans isomerase
HPM96_20530	COG1047	Peptidyl-prolyl cis-trans
HPM96_20535	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
HPM96_20550	COG0488	(ABC) transporter
HPM96_20555	COG0429	hydrolase of the alpha beta-hydrolase fold
HPM96_20565	COG3954	Phosphoribulokinase
HPM96_20570	COG1765	OsmC-like protein
HPM96_20575	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HPM96_20580	COG1289	transmembrane transporter activity
HPM96_20585	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HPM96_20590	COG0512	Glutamine amidotransferase of anthranilate synthase
HPM96_20595	COG2184	nucleotidyltransferase activity
HPM96_20605	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HPM96_20615	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HPM96_20620	COG2146	nitrite reductase [NAD(P)H] activity
HPM96_20625	COG2116	formate transmembrane transporter activity
HPM96_20640	COG0626	cystathionine gamma-synthase activity
HPM96_20655	COG1735	metal-dependent hydrolase with the TIM-barrel fold
HPM96_20660	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
HPM96_20665	COG3457	Alanine racemase
HPM96_20675	COG2188	Transcriptional regulator
HPM96_20680	COG0180	Tryptophanyl-tRNA synthetase
HPM96_20690	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HPM96_20695	COG0338	D12 class N6 adenine-specific DNA methyltransferase
HPM96_20700	COG3266	domain, Protein
HPM96_20715	COG4796	Type ii and iii secretion system protein
HPM96_20730	COG3166	PFAM Fimbrial assembly family protein
HPM96_20735	COG4972	Pilus assembly protein
HPM96_20740	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
HPM96_20745	COG0494	nUDIX hydrolase
HPM96_20755	COG1011	Hydrolase
HPM96_20760	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HPM96_20770	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
HPM96_20790	COG2205	protein histidine kinase activity
HPM96_20795	COG0745	RESPONSE REGULATOR receiver
HPM96_20800	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HPM96_20805	COG2183	response to ionizing radiation
HPM96_20810	COG1918	ferrous iron import across plasma membrane
HPM96_20815	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
HPM96_20825	COG5464	transposase or invertase
HPM96_20835	COG1040	competence protein
HPM96_20845	COG2610	gluconate transmembrane transporter activity
HPM96_20850	COG1640	4-alpha-glucanotransferase
HPM96_20855	COG0058	SHG alpha-glucan phosphorylase activity
HPM96_20870	COG1690	Belongs to the RtcB family
HPM96_20875	COG4650	regulator
HPM96_20880	COG1349	DNA-binding transcription factor activity
HPM96_20895	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HPM96_20910	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HPM96_20915	COG0058	SHG alpha-glucan phosphorylase activity
HPM96_20935	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HPM96_20940	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HPM96_20945	COG2095	MarC family integral membrane protein
HPM96_20955	COG0514	ATP-dependent DNA helicase (RecQ)
HPM96_20960	COG2610	gluconate transmembrane transporter activity
HPM96_20965	COG3265	gluconokinase activity
HPM96_20970	COG1609	Transcriptional regulator
HPM96_20975	COG1741	Belongs to the pirin family
HPM96_20980	COG0673	inositol 2-dehydrogenase activity
HPM96_20985	COG1247	-acetyltransferase
HPM96_20990	COG3157	Type VI secretion system effector, Hcp
HPM96_21010	COG0405	Gamma-glutamyltransferase
HPM96_21020	COG0584	glycerophosphoryl diester phosphodiesterase
HPM96_21025	COG3842	ATPase activity
HPM96_21030	COG0395	ABC-type sugar transport system, permease component
HPM96_21035	COG1175	transmembrane transport
HPM96_21040	COG1653	transport
HPM96_21045	COG0410	ABC transporter
HPM96_21050	COG0411	ABC transporter
HPM96_21055	COG4177	L-phenylalanine transmembrane transporter activity
HPM96_21060	COG0559	Belongs to the binding-protein-dependent transport system permease family
HPM96_21065	COG0683	leucine binding
HPM96_21070	COG0456	acetyltransferase
HPM96_21075	COG0683	leucine binding
HPM96_21080	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HPM96_21085	COG2177	Part of the ABC transporter FtsEX involved in
HPM96_21090	COG2884	Cell division ATP-binding protein ftsE
HPM96_21095	COG0552	protein localization to endoplasmic reticulum
HPM96_21100	COG0742	ribosomal rna small subunit methyltransferase
HPM96_21105	COG3776	membrane
HPM96_21115	COG3714	YhhN family
HPM96_21135	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
HPM96_21145	COG0477	Major facilitator Superfamily
HPM96_21150	COG0628	permease
HPM96_21155	COG2091	lysine biosynthetic process via aminoadipic acid
HPM96_21160	COG0747	negative chemotaxis
HPM96_21165	COG0601	transmembrane transport
HPM96_21170	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HPM96_21200	COG0842	Transport permease protein
HPM96_21205	COG1129	ABC transporter
HPM96_21205	COG0842	Transport permease protein
HPM96_21210	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HPM96_21230	COG2081	HI0933 family
HPM96_21235	COG0306	phosphate transporter
HPM96_21245	COG0589	response to stress
HPM96_21250	COG3104	oligopeptide transport
HPM96_21260	COG0339	signal peptide processing
HPM96_21265	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
HPM96_21270	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HPM96_21280	COG0640	Transcriptional regulator
HPM96_21285	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HPM96_21290	COG1393	Belongs to the ArsC family
HPM96_21310	COG3065	identical protein binding
HPM96_21315	COG2197	response regulator
HPM96_21320	COG3720	iron ion transport
HPM96_21325	COG4771	TonB-dependent receptor
HPM96_21340	COG3721	Heme iron utilization protein
HPM96_21350	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HPM96_21360	COG1285	pathogenesis
HPM96_21375	COG3247	response to pH
HPM96_21380	COG2771	luxR family
HPM96_21390	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HPM96_21395	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HPM96_21400	COG2207	Transcriptional regulator
HPM96_21410	COG0076	glutamate decarboxylase activity
HPM96_21415	COG1858	cytochrome C peroxidase
HPM96_21425	COG2197	response regulator
HPM96_21430	COG0583	DNA-binding transcription factor activity
HPM96_21435	COG1295	ribonuclease BN
HPM96_21440	COG0477	Major facilitator Superfamily
HPM96_21445	COG2982	Protein involved in outer membrane biogenesis
HPM96_21450	COG2200	EAL domain
HPM96_21455	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HPM96_21460	COG0612	Peptidase, M16
HPM96_21470	COG2199	diguanylate cyclase activity
HPM96_21470	COG2200	EAL domain
HPM96_21475	COG0457	Tetratricopeptide repeat
HPM96_21475	COG3118	belongs to the thioredoxin family
HPM96_21480	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
HPM96_21485	COG1215	transferase activity, transferring glycosyl groups
HPM96_21490	COG1215	transferase activity, transferring glycosyl groups
HPM96_21515	COG2194	sulfuric ester hydrolase activity
HPM96_21540	COG0814	amino acid
HPM96_21545	COG4608	Belongs to the ABC transporter superfamily
HPM96_21550	COG0444	Belongs to the ABC transporter superfamily
HPM96_21555	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HPM96_21560	COG0601	transmembrane transport
HPM96_21565	COG0747	negative chemotaxis
HPM96_21575	COG2194	sulfuric ester hydrolase activity
HPM96_21580	COG2223	nitrite transmembrane transporter activity
HPM96_21585	COG5571	outer membrane autotransporter
HPM96_21590	COG2818	Glycosylase
HPM96_21595	COG0456	acetyltransferase
HPM96_21600	COG0243	molybdopterin cofactor binding
HPM96_21605	COG2885	chlorophyll binding
HPM96_21620	COG2944	sequence-specific DNA binding
HPM96_21625	COG1278	Cold shock
HPM96_21655	COG3274	enterobacterial common antigen metabolic process
HPM96_21660	COG4682	membrane
HPM96_21665	COG4682	membrane
HPM96_21670	COG1070	Carbohydrate kinase
HPM96_21680	COG4213	ABC transporter substrate-binding protein
HPM96_21685	COG1129	ABC transporter
HPM96_21690	COG4214	carbohydrate transport
HPM96_21695	COG1609	Transcriptional regulator
HPM96_21695	COG2207	Transcriptional regulator
HPM96_21700	COG2992	FlgJ-related protein
HPM96_21705	COG0366	Alpha amylase catalytic
HPM96_21710	COG3977	Valine--pyruvate aminotransferase
HPM96_21715	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HPM96_21720	COG1414	Transcriptional regulator
HPM96_21730	COG2731	YhcH YjgK YiaL family protein
HPM96_21735	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
HPM96_21740	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HPM96_21745	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HPM96_21750	COG1070	Carbohydrate kinase
HPM96_21755	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
HPM96_21760	COG3623	hexulose-6-phosphate isomerase
HPM96_21765	COG0235	Class ii aldolase
HPM96_21775	COG2211	Major facilitator Superfamily
HPM96_21785	COG1598	PFAM Uncharacterised protein family UPF0150
HPM96_21800	COG1012	belongs to the aldehyde dehydrogenase family
HPM96_21810	COG1454	alcohol dehydrogenase
HPM96_21815	COG3276	selenocysteine insertion sequence binding
HPM96_21825	COG0625	glutathione transferase activity
HPM96_21830	COG3210	domain, Protein
HPM96_21830	COG3468	outer membrane autotransporter barrel domain protein
HPM96_21875	COG1566	PFAM secretion protein HlyD family protein
HPM96_21885	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HPM96_21885	COG2213	PTS system mannitol-specific
HPM96_21895	COG3722	fumarate hydratase activity
HPM96_21915	COG5295	Hep Hag repeat protein
HPM96_21920	COG1620	l-lactate permease
HPM96_21925	COG2186	Transcriptional regulator
HPM96_21935	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HPM96_21940	COG1045	serine acetyltransferase
HPM96_21955	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HPM96_21960	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HPM96_21970	COG4942	peptidase
HPM96_21975	COG2861	carbohydrate metabolic process
HPM96_21980	COG1216	Glycosyl transferase, family 2
HPM96_21990	COG0156	8-amino-7-oxononanoate synthase activity
HPM96_22000	COG0859	PFAM glycosyl transferase family 9
HPM96_22005	COG0859	PFAM glycosyl transferase family 9
HPM96_22010	COG3307	-O-antigen
HPM96_22015	COG1216	Glycosyl transferase, family 2
HPM96_22020	COG1442	glycosyl transferase family 8
HPM96_22025	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HPM96_22040	COG0515	serine threonine protein kinase
HPM96_22045	COG0438	transferase activity, transferring glycosyl groups
HPM96_22050	COG0859	PFAM glycosyl transferase family 9
HPM96_22055	COG1519	Transferase
HPM96_22085	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HPM96_22110	COG1561	YicC-like family, N-terminal region
HPM96_22115	COG3645	SOS response
HPM96_22120	COG2860	membrane
HPM96_22130	COG0194	GDP metabolic process
HPM96_22140	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HPM96_22145	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HPM96_22150	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HPM96_22155	COG0786	glutamate:sodium symporter activity
HPM96_22160	COG2233	PERMEase
HPM96_22165	COG2982	Protein involved in outer membrane biogenesis
HPM96_22175	COG1940	carbohydrate kinase activity
HPM96_22190	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HPM96_22190	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HPM96_22195	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HPM96_22200	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HPM96_22200	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HPM96_22200	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HPM96_22205	COG3711	transcriptional antiterminator
HPM96_22210	COG1501	Belongs to the glycosyl hydrolase 31 family
HPM96_22215	COG2211	Major facilitator Superfamily
HPM96_22230	COG2814	Major facilitator Superfamily
HPM96_22235	COG0697	spore germination
HPM96_22240	COG1464	Belongs to the NlpA lipoprotein family
HPM96_22250	COG0457	Tetratricopeptide repeat
HPM96_22280	COG4932	domain protein
HPM96_22280	COG2373	Large extracellular alpha-helical protein
HPM96_22280	COG1388	LysM domain
HPM96_22305	COG2252	PERMEase
HPM96_22315	COG2271	Major facilitator Superfamily
HPM96_22320	COG2271	Major facilitator Superfamily
HPM96_22325	COG3851	Histidine kinase
HPM96_22330	COG2197	response regulator
HPM96_22345	COG0440	acetolactate synthase activity
HPM96_22350	COG0028	Belongs to the TPP enzyme family
HPM96_22365	COG2814	Major facilitator Superfamily
HPM96_22370	COG0641	radical SAM
HPM96_22380	COG2149	membrane
HPM96_22385	COG3119	arylsulfatase activity
HPM96_22390	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HPM96_22395	COG2207	Transcriptional regulator
HPM96_22410	COG2188	Transcriptional regulator
HPM96_22430	COG5645	(Lipo)protein
HPM96_22435	COG0823	Involved in the tonB-independent uptake of proteins
HPM96_22445	COG2271	Major facilitator Superfamily
HPM96_22455	COG0800	Aldolase
HPM96_22460	COG3734	2-keto-3-deoxy-galactonokinase
HPM96_22465	COG2186	Transcriptional regulator
HPM96_22475	COG0561	phosphatase activity
HPM96_22480	COG3753	Protein conserved in bacteria
HPM96_22485	COG0187	DNA topoisomerase II activity
HPM96_22495	COG0592	DNA-directed DNA polymerase activity
HPM96_22545	COG0814	amino acid
HPM96_22555	COG0583	DNA-binding transcription factor activity
HPM96_22560	COG2091	lysine biosynthetic process via aminoadipic acid
HPM96_22565	COG0431	NADPH-dependent FMN reductase
HPM96_22570	COG2252	PERMEase
HPM96_22575	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HPM96_22605	COG0704	Plays a role in the regulation of phosphate uptake
HPM96_22610	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HPM96_22615	COG0581	inorganic phosphate transmembrane transporter activity
HPM96_22620	COG0573	inorganic phosphate transmembrane transporter activity
HPM96_22625	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HPM96_22700	COG3312	ion transport
HPM96_22715	COG0716	FMN binding
HPM96_22720	COG1522	sequence-specific DNA binding
HPM96_22750	COG1129	ABC transporter
HPM96_22755	COG1172	Belongs to the binding-protein-dependent transport system permease family
HPM96_22760	COG1879	ABC-type sugar transport system periplasmic component
HPM96_22765	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HPM96_22770	COG1609	Transcriptional regulator
HPM96_22775	COG0477	Major facilitator Superfamily
HPM96_22780	COG2186	Transcriptional regulator
HPM96_22820	COG3085	chromosome segregation
HPM96_22825	COG0606	chelatase, subunit chli
HPM96_22845	COG3978	acetolactate synthase activity
HPM96_22850	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HPM96_22860	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HPM96_22865	COG0583	DNA-binding transcription factor activity
HPM96_22875	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HPM96_22880	COG3692	DNA binding
HPM96_22885	COG0210	DNA helicase
HPM96_22900	COG3118	belongs to the thioredoxin family
HPM96_22910	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
HPM96_22915	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HPM96_22920	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
HPM96_22925	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HPM96_22930	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
HPM96_22935	COG1088	dTDP-glucose 4,6-dehydratase activity
HPM96_22940	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
HPM96_22945	COG0456	acetyltransferase
HPM96_22950	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HPM96_22955	COG2244	polysaccharide biosynthetic process
HPM96_22975	COG1113	amino acid transport
HPM96_23000	COG0641	radical SAM
HPM96_23005	COG3119	arylsulfatase activity
HPM96_23010	COG3071	HemY protein
HPM96_23015	COG2959	enzyme of heme biosynthesis
HPM96_23020	COG1587	Uroporphyrinogen-III synthase
HPM96_23030	COG3072	Adenylate cyclase
HPM96_23050	COG5567	small periplasmic lipoprotein
HPM96_23060	COG3159	Protein conserved in bacteria
HPM96_23070	COG1011	Hydrolase
HPM96_23075	COG0210	DNA helicase
HPM96_23080	COG1912	Pfam S-adenosyl-l-methionine hydroxide adenosyltransferase
HPM96_23085	COG3698	Phosphodiester glycosidase
HPM96_23090	COG0598	Magnesium transport protein CorA
HPM96_23105	COG2962	Rard protein
HPM96_23110	COG2050	protein possibly involved in aromatic compounds catabolism
HPM96_23115	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
HPM96_23120	COG0514	ATP-dependent DNA helicase (RecQ)
HPM96_23125	COG1280	lysine exporter protein (LysE YggA)
HPM96_23130	COG1280	lysine exporter protein (LysE YggA)
HPM96_23135	COG2267	carboxylic ester hydrolase activity
HPM96_23140	COG0561	phosphatase activity
HPM96_23145	COG0697	spore germination
HPM96_23150	COG0583	DNA-binding transcription factor activity
HPM96_23160	COG0583	DNA-binding transcription factor activity
HPM96_23165	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HPM96_23175	COG0549	Belongs to the carbamate kinase family
HPM96_23180	COG1304	FMN binding
HPM96_23185	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HPM96_23195	COG1335	isochorismatase
HPM96_23200	COG0412	Dienelactone hydrolase
HPM96_23205	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
HPM96_23225	COG0800	Aldolase
HPM96_23230	COG3734	2-keto-3-deoxy-galactonokinase
HPM96_23235	COG1414	Transcriptional regulator
HPM96_23240	COG1322	Protein conserved in bacteria
HPM96_23250	COG3165	ubiquinone biosynthetic process from chorismate
HPM96_23260	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HPM96_23265	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HPM96_23270	COG0805	protein transport
HPM96_23280	COG0250	Participates in transcription elongation, termination and antitermination
HPM96_23285	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HPM96_23290	COG0543	2 iron, 2 sulfur cluster binding
HPM96_23310	COG1739	Uncharacterized protein family UPF0029
HPM96_23315	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HPM96_23320	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
HPM96_23350	COG1763	Mo-molybdopterin cofactor biosynthetic process
HPM96_23355	COG0746	molybdenum cofactor guanylyltransferase activity
HPM96_23360	COG3084	Protein conserved in bacteria
HPM96_23365	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HPM96_23370	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HPM96_23375	COG5339	Protein conserved in bacteria
HPM96_23380	COG0204	Acyl-transferase
HPM96_23385	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HPM96_23385	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HPM96_23400	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HPM96_23410	COG2204	response regulator
HPM96_23415	COG3852	Histidine kinase
HPM96_23420	COG0174	glutamine synthetase
HPM96_23430	COG3385	transposase activity
HPM96_23435	COG2188	Transcriptional regulator
HPM96_23440	COG1082	Xylose isomerase domain protein TIM barrel
HPM96_23445	COG2271	Major facilitator Superfamily
HPM96_23450	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
HPM96_23455	COG2211	Major facilitator Superfamily
HPM96_23460	COG2211	Major facilitator Superfamily
HPM96_23465	COG1501	Belongs to the glycosyl hydrolase 31 family
HPM96_23470	COG2017	converts alpha-aldose to the beta-anomer
HPM96_23475	COG2942	2-epimerase
HPM96_23480	COG3684	Belongs to the aldolase LacD family
HPM96_23485	COG2084	Dehydrogenase
HPM96_23490	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HPM96_23495	COG1349	DNA-binding transcription factor activity
HPM96_23500	COG1011	Hydrolase
HPM96_23515	COG0456	acetyltransferase
HPM96_23525	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HPM96_23530	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HPM96_23545	COG2864	formate dehydrogenase
HPM96_23550	COG0437	4 iron, 4 sulfur cluster binding
HPM96_23565	COG0326	Molecular chaperone. Has ATPase activity
HPM96_23580	COG3711	transcriptional antiterminator
HPM96_23580	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HPM96_23585	COG1363	Peptidase, m42
HPM96_23590	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HPM96_23590	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HPM96_23595	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HPM96_23615	COG3547	Transposase (IS116 IS110 IS902 family)
HPM96_23620	COG4806	L-rhamnose isomerase
HPM96_23635	COG4977	sequence-specific DNA binding
HPM96_23635	COG1917	Cupin 2, conserved barrel domain protein
HPM96_23645	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HPM96_23655	COG2258	MOSC domain
HPM96_23660	COG2205	protein histidine kinase activity
HPM96_23665	COG0745	RESPONSE REGULATOR receiver
HPM96_23670	COG3678	ATP-independent chaperone mediated protein folding
HPM96_23685	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
HPM96_23705	COG3152	Membrane
HPM96_23710	COG3691	Protein conserved in bacteria
HPM96_23715	COG0589	response to stress
HPM96_23725	COG1494	fructose-1,6-bisphosphatase
HPM96_23735	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HPM96_23760	COG1575	Belongs to the MenA family. Type 1 subfamily
HPM96_23775	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HPM96_23780	COG1609	Transcriptional regulator
HPM96_23785	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HPM96_23795	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
HPM96_23805	COG0626	cystathionine gamma-synthase activity
HPM96_23810	COG0527	aspartate kinase activity
HPM96_23810	COG0460	homoserine dehydrogenase
HPM96_23820	COG0737	Belongs to the 5'-nucleotidase family
HPM96_23825	COG0737	Belongs to the 5'-nucleotidase family
HPM96_23835	COG0737	Belongs to the 5'-nucleotidase family
HPM96_23840	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HPM96_23850	COG0697	spore germination
HPM96_23855	COG3738	Protein conserved in bacteria
HPM96_23860	COG0371	Dehydrogenase
HPM96_23865	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HPM96_23870	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HPM96_23870	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HPM96_23870	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HPM96_23875	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HPM96_23880	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HPM96_23885	COG1882	Formate acetyltransferase
HPM96_23890	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HPM96_23895	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HPM96_23900	COG2207	Transcriptional regulator
HPM96_23905	COG2194	sulfuric ester hydrolase activity
HPM96_23920	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HPM96_23935	COG4948	Mandelate Racemase Muconate Lactonizing
HPM96_23940	COG2271	Major facilitator Superfamily
HPM96_23945	COG0583	DNA-binding transcription factor activity
HPM96_23955	COG1309	transcriptional regulator
HPM96_23970	COG4206	TonB-dependent receptor
HPM96_23975	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HPM96_24005	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
HPM96_24005	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
HPM96_24040	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HPM96_24045	COG0250	Participates in transcription elongation, termination and antitermination
HPM96_24080	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HPM96_24100	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HPM96_24110	COG2104	thiamine diphosphate biosynthetic process
HPM96_24115	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HPM96_24150	COG3068	Protein conserved in bacteria
HPM96_24165	COG3678	ATP-independent chaperone mediated protein folding
HPM96_24170	COG4191	Histidine kinase
HPM96_24175	COG2204	response regulator
HPM96_24180	COG0151	Belongs to the GarS family