locus-tag class description D9E17_00010 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) D9E17_00020 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) D9E17_00025 ENOG4105VP5 Bacterial protein of unknown function (DUF937) D9E17_00030 ENOG410667J hydrolase D9E17_00035 ENOG410657R replicase EC 2.7 D9E17_00040 ENOG4105EMF GntR family transcriptional regulator D9E17_00045 ENOG4105EI3 2-dehydro-3-deoxygalactonokinase EC 2.7.1.58 D9E17_00050 ENOG4108RTU Aldolase D9E17_00060 ENOG4105DJB Major Facilitator Superfamily D9E17_00070 ENOG4105D99 atp gtp-binding protein D9E17_00075 ENOG4105R2A (LipO)protein D9E17_00095 ENOG4105FDP GntR family transcriptional regulator D9E17_00120 ENOG4105D7V transposase D9E17_00125 ENOG4105VG5 Membrane D9E17_00130 ENOG4105JP4 Inner membrane protein yidG D9E17_00135 ENOG4105J13 transcriptional regulator D9E17_00140 ENOG4105E5M Multidrug resistance protein D D9E17_00155 ENOG4105C7K acetolactate synthase D9E17_00160 ENOG4105M71 acetolactate synthase 1 regulatory subunit D9E17_00165 ENOG4108KX4 response regulator D9E17_00170 ENOG4105BZU Histidine kinase D9E17_00175 ENOG4105CXY transporter D9E17_00180 ENOG4105CXY transporter D9E17_00190 ENOG4105C7N Xanthine uracil vitamin C permease D9E17_00195 ENOG4108SAJ Protein of unknown function (DUF1198) D9E17_00205 ENOG4105T8A Uncharacterized protein YicS D9E17_00210 ENOG4105D01 (LipO)protein D9E17_00215 ENOG4108UZ3 Transporter D9E17_00220 ENOG4105S8Q sugar efflux transporter D9E17_00235 ENOG4105CT4 transporter D9E17_00240 ENOG4105CJQ hydrolase, family 31 D9E17_00245 ENOG4105JV1 AsmA family D9E17_00250 ENOG4105C2W permease D9E17_00255 ENOG4105D6U Sodium Glutamate Symporter D9E17_00260 ENOG4105CB5 ATP-dependent DNA helicase recG D9E17_00265 ENOG4105FE8 tRNA (Guanosine-2'-O-)-methyltransferase D9E17_00270 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) D9E17_00275 ENOG4105VFG Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) D9E17_00280 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) D9E17_00290 ENOG4105EN6 Membrane D9E17_00300 ENOG4105DSJ YicC domain protein D9E17_00325 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase D9E17_00340 ENOG4105W0E 50S ribosomal protein L33 D9E17_00355 ENOG4105D8A 3-Deoxy-D-manno-octulosonic-acid transferase D9E17_00360 ENOG4105DKP glycosyl transferase, family 9 D9E17_00365 ENOG4107RJ7 Glycosyl transferase (Group 1 D9E17_00370 ENOG4107543 (lipo)polysaccharide D9E17_00375 ENOG4106AH0 Glycosyl Transferase D9E17_00380 ENOG4105X1N Glycosyl transferase family 8 D9E17_00390 ENOG4105X1N Glycosyl transferase family 8 D9E17_00395 ENOG4105K64 Glycosyl transferase, family 2 D9E17_00400 ENOG41068PG O-Antigen polymerase D9E17_00405 ENOG4105D16 lipopolysaccharide heptosyltransferase i D9E17_00410 ENOG4105XA0 heptosyltransferase ii D9E17_00420 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) D9E17_00430 ENOG4105K64 Glycosyl transferase, family 2 D9E17_00435 ENOG4105PXI polysaccharide deacetylase D9E17_00440 ENOG41063SB peptidase D9E17_00450 ENOG4107YZP Rhodanese domain protein D9E17_00455 ENOG4105VW4 glutaredoxin 3 D9E17_00470 ENOG4105D7W serine acetyltransferase D9E17_00475 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) D9E17_00485 ENOG41073TP transcriptional regulator D9E17_00490 ENOG4105DAA L-lactate D9E17_00495 ENOG4105EUR Domain-Containing protein D9E17_00500 ENOG4108WY4 inner membrane lipoprotein D9E17_00510 ENOG4108YYI Protein of unknown function (DUF2810) D9E17_00520 ENOG4105E61 Mannitol repressor protein D9E17_00530 ENOG4105CTS PTS system mannitol-specific D9E17_00535 ENOG4105FP6 Protein of unknown function (DUF3302) D9E17_00540 ENOG4105EFX secretion protein, HlyD family D9E17_00570 ENOG4105NUP lyase containing HEAT-repeat D9E17_00575 ENOG4105CNA YD repeat protein D9E17_00580 ENOG4108U78 Glutathione S-transferase D9E17_00590 ENOG4105EM7 Selenocysteine-specific translation elongation factor D9E17_00595 ENOG4105C0A alcohol dehydrogenase D9E17_00600 ENOG4105C26 Dehydrogenase D9E17_00610 ENOG4105KK7 inner membrane protein YiaW D9E17_00615 ENOG4105EFX secretion protein, HlyD family D9E17_00620 ENOG4108Q2M Transcriptional regulator D9E17_00625 ENOG4105GNX MltA-interacting MipA family protein D9E17_00635 ENOG4105CT4 transporter D9E17_00645 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase D9E17_00650 ENOG41064BZ L-xylulose 5-phosphate 3-epimerase D9E17_00655 ENOG4105H6Q decarboxylase D9E17_00660 ENOG4105CMG Carbohydrate kinase D9E17_00665 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit D9E17_00670 ENOG4105CG6 trap dicarboxylate transporter dctm subunit D9E17_00675 ENOG4105XDZ Tripartite ATP-independent periplasmic transporter D9E17_00680 ENOG4108R66 Conserved Protein D9E17_00690 ENOG4105J4Q Transcriptional regulator D9E17_00695 ENOG4108XIB electron transport protein ysaA D9E17_00700 ENOG4105JKW Valine--pyruvate aminotransferase D9E17_00705 ENOG4107T9C Alpha amylase catalytic region D9E17_00710 ENOG4108UR8 BAX protein D9E17_00715 ENOG4105T16 Transcriptional regulator (AraC family) D9E17_00720 ENOG4107RNG ABC transporter D9E17_00725 ENOG4105C2J ABC transporter D9E17_00730 ENOG4105DFW ABC transporter D9E17_00740 ENOG4105CMG Carbohydrate kinase D9E17_00745 ENOG410688U Inner membrane protein yiaB D9E17_00750 ENOG4108Z12 YiaAB two helix domain-containing protein D9E17_00755 ENOG4105MEV Acyl-transferase D9E17_00760 ENOG4105RGS lipoprotein ysaB D9E17_00765 ENOG4108HMW glycyl-tRNA synthetase, alpha subunit D9E17_00780 ENOG41060TC Hok gef cell toxic protein D9E17_00785 ENOG4105VEQ Cold shock protein D9E17_00790 ENOG4105MVF Transcriptional regulator D9E17_00795 ENOG4106JH6 (LipO)protein D9E17_00800 ENOG4105C5I Dehydrogenase D9E17_00805 ENOG4108ZG0 Ompa motb domain protein D9E17_00810 ENOG4107QY8 reductase D9E17_00815 ENOG4105HNP -acetyltransferase D9E17_00820 ENOG4108R3E Dna-3-methyladenine glycosylase i D9E17_00825 ENOG4105EAX Putative lipase D9E17_00830 ENOG4105FCD Major Facilitator D9E17_00835 ENOG4105DIJ Phosphoethanolamine transferase D9E17_00845 ENOG4105DEF Extracellular solute-binding protein, family 5 D9E17_00855 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component D9E17_00860 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component D9E17_00865 ENOG4105C3U ABC transporter D9E17_00870 ENOG4108JQ7 (ABC) transporter D9E17_00875 ENOG4105C44 Serine transporter D9E17_00890 ENOG4105D1V cellulose synthase operon protein YhjU D9E17_00895 ENOG4105WQA Cellulose biosynthesis protein BcsF D9E17_00900 ENOG4105U74 cellulose biosynthesis protein BcsE D9E17_00910 ENOG4105U74 cellulose biosynthesis protein BcsE D9E17_00915 ENOG410661M cytoplasmic protein D9E17_00925 ENOG4107QZ7 Cellulose synthase catalytic subunit D9E17_00940 ENOG4105EJG cellulose synthase D9E17_00945 ENOG4105BZU Histidine kinase D9E17_00955 ENOG4105CS0 peptidase D9E17_00960 ENOG4107SS6 2-dehydro-3-deoxygluconokinase D9E17_00965 ENOG4105CMB EAL domain-containing protein D9E17_00970 ENOG41066T0 asmA family D9E17_00975 ENOG4105CSH Transporter D9E17_00980 ENOG4107H3J ribonuclease D9E17_00985 ENOG4105CBN LysR family transcriptional regulator D9E17_00990 ENOG4106S2D Transcriptional regulator D9E17_01025 ENOG4105CVK Glutamate decarboxylase D9E17_01035 ENOG4108NKV transcriptional regulator D9E17_01040 ENOG4105D3F AraC Family Transcriptional Regulator D9E17_01045 ENOG4105BZS acriflavin resistance protein D9E17_01050 ENOG4105C1P efflux transporter, rnd family, mfp subunit D9E17_01060 ENOG4106WJ0 Regulates the expression of several genes involved in acid resistance. Required for the expression of gadA and gadBC, among others, regardless of media or growth conditions. Binds directly to the 20 bp GAD box found in the control regions of both loci D9E17_01065 ENOG4108YK4 Acid-resistance membrane protein D9E17_01070 ENOG41060V2 Acid-resistance protein D9E17_01075 ENOG4105XXV Acid-resistance protein D9E17_01080 ENOG4105KT7 mgtC SapB transporter D9E17_01090 ENOG4105Y4Z Outer Membrane Lipoprotein D9E17_01100 ENOG4105K89 arsenate reductase D9E17_01105 ENOG4107R5R arsenical pump membrane protein D9E17_01110 ENOG4105KBH arsR family transcriptional regulator D9E17_01120 ENOG4105DC8 reductase D9E17_01125 ENOG4105D6S protein involved in catabolism of external DNA D9E17_01130 ENOG4105DGW oligopeptidase A D9E17_01135 ENOG4105FFN Specifically methylates the guanosine in position 1516 of 16S rRNA (By similarity) D9E17_01140 ENOG4105DUX Transporter D9E17_01145 ENOG4108M6U Universal stress protein A D9E17_01155 ENOG4105CJ3 phosphate transporter D9E17_01160 ENOG4105CBX hi0933 family D9E17_01245 ENOG410624V efflux system protein D9E17_01275 ENOG4105DR5 peptidase D9E17_01285 ENOG4105E3B Multicopper oxidase D9E17_01290 ENOG4105VR0 copper resistance D9E17_01295 ENOG4105JDN Copper resistance protein D9E17_01300 ENOG4108PG2 copper resistance D9E17_01305 ENOG4105CK6 Two component transcriptional regulator (Winged helix family D9E17_01310 ENOG4105GR3 Histidine kinase D9E17_01320 ENOG4107UNS conserved inner membrane protein D9E17_01335 ENOG4105D0S secretion protein (HlyD D9E17_01340 ENOG4105CJ1 ABC, transporter D9E17_01345 ENOG4105CMI transporter D9E17_01350 ENOG410600T transposase D9E17_01355 ENOG4105NUP lyase containing HEAT-repeat D9E17_01365 ENOG4105CNA YD repeat protein D9E17_01375 ENOG4105EFJ Part of the ABC transporter complex NikABCDE involved in nickel import. Responsible for energy coupling to the transport system (By similarity) D9E17_01380 ENOG4106665 Part of the ABC transporter complex NikABCDE involved in nickel import. Responsible for energy coupling to the transport system (By similarity) D9E17_01385 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component D9E17_01390 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component D9E17_01395 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein D9E17_01400 ENOG4107YAK holo-(acyl carrier protein) synthase 2 D9E17_01405 ENOG4105DSF transport protein D9E17_01410 ENOG4105F9N Major Facilitator Superfamily D9E17_01415 ENOG4108W1V Lipoprotein D9E17_01420 ENOG4105EX9 Membrane D9E17_01435 ENOG4107FS9 Membrane D9E17_01445 ENOG4105MG3 Membrane D9E17_01450 ENOG4106H78 methyltransferase D9E17_01455 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) D9E17_01460 ENOG4105CAK Cell division ATP-binding protein ftsE D9E17_01465 ENOG4105CRP Part of the ABC transporter FtsEX involved in D9E17_01470 ENOG4105DEK Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) D9E17_01475 ENOG4105CP9 extracellular ligand-binding receptor D9E17_01480 ENOG4105U59 -acetyltransferase D9E17_01485 ENOG4105CP9 extracellular ligand-binding receptor D9E17_01490 ENOG4105C32 Amino acid ABC transporter (Permease) D9E17_01495 ENOG4105CF8 branched-chain amino acid ABC transporter, permease D9E17_01500 ENOG4105C0Z ABC transporter D9E17_01505 ENOG4108IV0 ABC, transporter D9E17_01510 ENOG4105BZ7 extracellular solute-binding protein family 1 D9E17_01515 ENOG4105E4X binding-protein-dependent transport systems inner membrane Component D9E17_01520 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component D9E17_01525 ENOG4108IJ9 (ABC) transporter D9E17_01530 ENOG4107T6V glycerophosphoryl diester phosphodiesterase D9E17_01535 ENOG4105WC8 Conserved Protein D9E17_01540 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) D9E17_01545 ENOG4106FA4 D9E17_01565 ENOG4105GMB type VI secretion system effector, hcp1 family D9E17_01570 ENOG4105WCN acetyltransferase D9E17_01575 ENOG4105D9R oxidoreductase D9E17_01580 ENOG4105C2I pirin domain protein D9E17_01585 ENOG4105DIQ Transcriptional regulator D9E17_01590 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family D9E17_01595 ENOG4105C6Z Gluconate D9E17_01600 ENOG41076UM multiple antibiotic resistance (MarC)-related protein D9E17_01605 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) D9E17_01615 ENOG4108IUM Glycogen debranching enzyme D9E17_01630 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) D9E17_01655 ENOG4105C6V Glycerol-3-phosphate dehydrogenase D9E17_01670 ENOG4105E98 transcriptional regulator DeoR family D9E17_01675 ENOG4105CYB regulatoR D9E17_01680 ENOG4105E0Y RtcB Protein D9E17_01695 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) D9E17_01700 ENOG4107RTM 4-alpha-glucanotransferase (EC 2.4.1.25) D9E17_01705 ENOG4105C6Z Gluconate D9E17_01715 ENOG4105MJ2 Competence protein D9E17_01725 ENOG4105DNE Transposase D9E17_01735 ENOG4105CE1 Ferrous iron transport protein b D9E17_01740 ENOG4105XFK Ferrous iron transport protein A D9E17_01745 ENOG4105BZM domain protein D9E17_01750 ENOG4108RRZ Transcription elongation factor GreB D9E17_01755 ENOG4105DPZ Two component transcriptional regulator (Winged helix family D9E17_01760 ENOG4105E0F Histidine kinase D9E17_01770 ENOG4108MAJ Membrane D9E17_01780 ENOG4105VEJ Heat shock protein D9E17_01785 ENOG4107Y3D HAD-superfamily hydrolase subfamily IA variant 3 D9E17_01790 ENOG4105DQY intracellular growth attenuator D9E17_01795 ENOG4107RK2 ADP-ribose diphosphatase NudE D9E17_01800 ENOG4108JQC penicillin-binding protein 1A D9E17_01805 ENOG4108U1Q Pilus assembly protein D9E17_01810 ENOG41065NF Fimbrial assembly family protein D9E17_01815 ENOG4105XPX DNA utilization protein HofO D9E17_01820 ENOG4105ITY Required for the use of extracellular DNA as a nutrient D9E17_01825 ENOG4105E4G Type IV pilus D9E17_01840 ENOG4105EGB membrane protein DamX D9E17_01845 ENOG4105DFE Dna adenine methylase D9E17_01850 ENOG4105DJV ribulose-phosphate 3-epimerase D9E17_01855 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) D9E17_01860 ENOG4105C31 Tryptophanyl-tRNA synthetase D9E17_01870 ENOG4108M21 D9E17_01875 ENOG4105RMW regulation of transcription, DNA-dependent D9E17_01880 ENOG4108626 Racemase D9E17_01885 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) D9E17_01890 ENOG41080QX K07048 phosphotriesterase-related protein D9E17_01895 ENOG4105MUZ Protein of unknown function DUF2620 D9E17_01900 ENOG4106M0N transport system permease protein D9E17_01905 ENOG4106PKC pyridoxal phosphate binding D9E17_01910 ENOG4105FDP GntR family transcriptional regulator D9E17_01915 ENOG4108KPW sugar kinase D9E17_01920 ENOG4107Y0V Not clear, may be involved in an isomerization step D9E17_01925 ENOG4107R1S catalyzes the conversion of fructoselysine 6-phosphate to glucose 6-phosphate and lysine D9E17_01930 ENOG4107QHQ amino acid D9E17_01935 ENOG4105VYH D9E17_01945 ENOG4107V9H nitrite transporter D9E17_01950 ENOG4105WZK nitrite reductase NADPH small subunit D9E17_01955 ENOG4107QZF nitrite reductase NADPH large subunit D9E17_01965 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) D9E17_01970 ENOG4106195 uncharacterized protein yhfG D9E17_01975 ENOG4105MZU cell filamentation protein D9E17_01980 ENOG4105DDQ anthranilate synthase D9E17_01985 ENOG4105C8Y Acetylornithine aminotransferase D9E17_01990 ENOG410613R integral membrane protein, YccS YhfK family D9E17_01995 ENOG4107RYR Transcriptional regulator, Crp Fnr family D9E17_02000 ENOG4108UKZ OsmC family D9E17_02005 ENOG4105CJE phosphoribulokinase (EC 2.7.1.19) D9E17_02015 ENOG4105DNZ Alpha Beta Hydrolase D9E17_02020 ENOG4105C5H ABC transporter D9E17_02035 ENOG4105VKU nucleicacid-binding protein D9E17_02040 ENOG4108YZY peptidylprolyl cis-trans isomerase D9E17_02050 ENOG4108V1T peptidylprolyl cis-trans isomerase D9E17_02055 ENOG4105WWK YheO domain protein D9E17_02095 ENOG4108NNZ chitinase D9E17_02100 ENOG4105W53 bacterioferritin-associated ferredoxin D9E17_02105 ENOG4108UQY Iron-storage protein D9E17_02110 ENOG4105EHH Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue (By similarity) D9E17_02120 ENOG41063JA Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins (By similarity) D9E17_02125 ENOG4105R04 type II secretion system protein K D9E17_02140 ENOG41069X0 general secretion pathway protein h D9E17_02145 ENOG4108VAU general secretion pathway protein G D9E17_02150 ENOG4105D7Q type ii secretion system D9E17_02160 ENOG4105GVR general secretion pathway protein D D9E17_02165 ENOG4107KSE General secretion pathway protein C D9E17_02170 ENOG410899B May play a regulatory role under conditions of derepressed gsp gene expression D9E17_02175 ENOG4107ACA Calcium-binding protein required for initiation of chromosome replication D9E17_02190 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) D9E17_02195 ENOG41080KG One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) D9E17_02205 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) D9E17_02210 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) D9E17_02215 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) D9E17_02220 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) D9E17_02230 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal D9E17_02240 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) D9E17_02255 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) D9E17_02265 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) D9E17_02270 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) D9E17_02280 ENOG4108UZ0 Binds to the 23S rRNA (By similarity) D9E17_02285 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) D9E17_02290 ENOG41067V7 50S ribosomal protein L36 D9E17_02295 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits D9E17_02305 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) D9E17_02310 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) D9E17_02320 ENOG4105VTS DnaJ-like, subfamily C D9E17_02325 ENOG4105W1Y Transcriptional regulator D9E17_02330 ENOG4105VCN Rescues the ribosomes stalled at the 3' end of non-stop mRNAs. May induce hydrolysis of the ribosome-bound peptidyl-tRNA. This activity is crucial when the stalled ribosome can not be rescued by the SsrA(tmRNA)-SmpB quality control system D9E17_02340 ENOG4105C1A potassium transporter peripheral membrane D9E17_02360 ENOG4105C79 DNA protecting protein DprA D9E17_02370 ENOG4108WI1 Dna topoisomerase D9E17_02380 ENOG4105E2X shikimate dehydrogenase D9E17_02385 ENOG4105SG3 Protein of unknown function (DUF1488) D9E17_02390 ENOG4108Z0R Transferase D9E17_02435 ENOG4105CDA abc transporter atp-binding protein D9E17_02440 ENOG4105DRP amino acid AbC transporter D9E17_02445 ENOG4105EZ7 amino acid ABC transporter D9E17_02455 ENOG4105XCM membrane LIPOPROTEIN D9E17_02460 ENOG4105BZS acriflavin resistance protein D9E17_02465 ENOG4105C1P efflux transporter, rnd family, mfp subunit D9E17_02470 ENOG4108XG4 DNA-binding transcriptional regulator D9E17_02475 ENOG41061ME transport protein D9E17_02480 ENOG4105CEC DNA methylase N-4 N-6 D9E17_02485 ENOG4105VY0 Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters (By similarity) D9E17_02490 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) D9E17_02500 ENOG4108IA2 Sodium pantothenate symporter D9E17_02505 ENOG4105RG0 Membrane D9E17_02510 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase D9E17_02515 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein D9E17_02520 ENOG4105D3Z quinone oxidoreductase, yhdh yhfp family D9E17_02525 ENOG41062P1 Diguanylate cyclase phosphodiesterase D9E17_02530 ENOG4105DFF Rod shape-determining protein mreb D9E17_02535 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) D9E17_02540 ENOG4105VQ7 Rod shape-determining protein MreD D9E17_02550 ENOG4105C03 ribonuclease D9E17_02555 ENOG4105QD6 exported protein D9E17_02560 ENOG4105D1U peptidase U62 modulator of DNA gyrase D9E17_02565 ENOG4105CR8 Transcriptional regulator D9E17_02585 ENOG4105UNR (Barnase) inhibitor D9E17_02590 ENOG4105RID UPF0379 protein yhcN D9E17_02605 ENOG4105C0H protease D9E17_02610 ENOG4105C0H protease D9E17_02615 ENOG4108W2Q Cytochrome d ubiquinol oxidase subunit III D9E17_02620 ENOG4105D6Z AFG1 family ATPase D9E17_02630 ENOG4108UJD 30S ribosomal protein S9 D9E17_02640 ENOG4107MKT Stringent starvation protein a D9E17_02645 ENOG4105KB2 stringent starvation protein b D9E17_02650 ENOG4105CEE C4-dicarboxylate transporter D9E17_02675 ENOG41061DF Catalyzes the phosphorylation of N-acetylmannosamine (ManNAc) to ManNAc-6-P (By similarity) D9E17_02680 ENOG4108R66 Conserved Protein D9E17_02690 ENOG4105DFS Conserved Protein D9E17_02695 ENOG4105BZ8 glutamate synthase D9E17_02700 ENOG4105CBC glutamate synthase D9E17_02705 ENOG4105N5T Radical SAM Protein D9E17_02710 ENOG4105BZU Histidine kinase D9E17_02715 ENOG4108556 Isoprenoid biosynthesis protein with amidotransferase-like domain D9E17_02720 ENOG4108VKV Monofunctional biosynthetic peptidoglycan transglycosylase D9E17_02725 ENOG4108NIH transferase activity, transferring phosphorus-containing groups D9E17_02730 ENOG41080Z8 PHOSPHOCARRIER protein D9E17_02740 ENOG4107RM2 PTS IIA-like nitrogen-regulatory protein PtsN D9E17_02745 ENOG41080QH sigma 54 modulation protein ribosomal protein S30EA D9E17_02750 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) D9E17_02755 ENOG4108IUZ ABC transporter D9E17_02760 ENOG4105WI0 lipopolysaccharide transport periplasmic protein lptA D9E17_02765 ENOG4108P1K Required for the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane (By similarity) D9E17_02775 ENOG4105C2X Arabinose 5-phosphate isomerase D9E17_02780 ENOG4105FEU K -dependent Na -Ca exchanger D9E17_02785 ENOG4105DHJ ABC, transporter D9E17_02790 ENOG4105CY3 ABC transporter, permease D9E17_02795 ENOG4107PE3 Mammalian cell entry related domain protein D9E17_02800 ENOG4105E3I toluene tolerance D9E17_02805 ENOG4105UE2 Part of the ABC transporter complex MlaFEDB that actively prevents phospholipid accumulation at the cell surface. Probably maintains lipid asymmetry in the outer membrane by retrograde trafficking of phospholipids from the outer membrane to the inner membrane D9E17_02810 ENOG4105VFK BolA family D9E17_02820 ENOG4105HVQ Regulatory factor of maltose metabolism D9E17_02825 ENOG4105EAH synthase D9E17_02840 ENOG4105QYV Membrane D9E17_02850 ENOG4106HRJ d-alanyl-d-alanine carboxypeptidase D9E17_02855 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) D9E17_02860 ENOG4105HBR Rna-binding protein D9E17_02865 ENOG4105F7M Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit (By similarity) D9E17_02870 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) D9E17_02875 ENOG4105EEI dihydropteroate synthase D9E17_02895 ENOG4105DIJ Phosphoethanolamine transferase D9E17_02915 ENOG4105CHV Transcription elongation factor NusA D9E17_02930 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) D9E17_02945 ENOG4105RT1 May be involved in cell division (By similarity) D9E17_02955 ENOG4105C1J atp-dependent rna helicase D9E17_02960 ENOG4105CIC tryptophan-specific transport protein D9E17_02965 ENOG4105DEN Luciferase family D9E17_02970 ENOG4106RZ4 Peptidase U32 D9E17_02975 ENOG4105CFP Peptidase U32 D9E17_02980 ENOG4105XPQ lipid carrier protein D9E17_02985 ENOG4108YYD acetyltransferase D9E17_03000 ENOG4107R7Y intracellular protease Pfpi family D9E17_03005 ENOG4105K4T epimerase D9E17_03010 ENOG4107S21 permease D9E17_03015 ENOG4105W4M Transport-associated protein D9E17_03020 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) D9E17_03030 ENOG4105E1C Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1A (PBP1a) (By similarity) D9E17_03035 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) D9E17_03040 ENOG4105I74 Fimbrial protein D9E17_03045 ENOG4105CW0 outer membrane usher protein D9E17_03050 ENOG4108VCD Chaperone D9E17_03055 ENOG4105Q10 Fimbrial-like protein D9E17_03060 ENOG4106HBN Galactosamine-6-phosphate isomerase D9E17_03065 ENOG4105F3R pts system mannose fructose sorbose family iid D9E17_03070 ENOG4105ETZ PTS System D9E17_03075 ENOG4108UZY PTS System D9E17_03085 ENOG4105E70 isomerase D9E17_03090 ENOG4105CE4 GlcNAc 6-P deacetylase D9E17_03095 ENOG4108YTN IIa component D9E17_03100 ENOG4105F3R pts system mannose fructose sorbose family iid D9E17_03110 ENOG4108RG5 PTS system N-acetylgalactosamine-specific transporter subunit IIB D9E17_03120 ENOG4105E98 transcriptional regulator DeoR family D9E17_03125 ENOG4108R8Z these effects are overcome by concomitant expression of antitoxin SohA (PrlF). Massive overexpression is toxic. Unlike most other characterized TA systems degrades rRNA, and co-folding of the proteins is necessary in vitro for inhibition of the RNase activity. It is not known if it has any sequence-specificity. Acts as a transcription factor. The YhaV PrlF complex binds the prlF-yhaV operon, probably negatively regulating its expression D9E17_03130 ENOG4105ZEG Suppressor protein D9E17_03135 ENOG4105CTX dehydratase D9E17_03140 ENOG4105DJB Major Facilitator Superfamily D9E17_03150 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase D9E17_03155 ENOG4105BZW Glycerate kinase D9E17_03180 ENOG410811B TRANSCRIPTIONal D9E17_03185 ENOG4105C7B Threonine dehydratase D9E17_03190 ENOG4108MST Involved in the import of threonine and serine into the cell, with the concomitant import of a proton (symport system) (By similarity) D9E17_03195 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) D9E17_03200 ENOG4105C6N Formate acetyltransferase D9E17_03205 ENOG4105KME endoribonuclease L-psp D9E17_03210 ENOG4105EJQ L-serine dehydratase D9E17_03215 ENOG4105C44 Serine transporter D9E17_03225 ENOG4106D80 Uncharacterized protein YhaL D9E17_03230 ENOG4108CNN domain protein D9E17_03235 ENOG4105CWB LysR family transcriptional Regulator D9E17_03240 ENOG4105KAF membrAne D9E17_03245 ENOG4105KAF membrAne D9E17_03250 ENOG4105CHF Glutathione S-transferase D9E17_03255 ENOG4108VBZ doxx family D9E17_03260 ENOG4105YJD D9E17_03265 ENOG41090KG Inner membrane protein YqjE D9E17_03270 ENOG4105NE1 Conserved Protein D9E17_03275 ENOG4105WAY exported protein D9E17_03280 ENOG4105IYR Modulates the activity of the EnvZ OmpR two-component regulatory system, probably by directly modulating EnvZ enzymatic activity and increasing stability of phosphorylated OmpR (By similarity) D9E17_03285 ENOG4106W5V Membrane D9E17_03290 ENOG4107YCY Transcriptional regulator D9E17_03315 ENOG4105DPW Major facilitator superfamily MFS_1 D9E17_03325 ENOG4105CTX dehydratase D9E17_03330 ENOG4105P66 Membrane D9E17_03335 ENOG4107QV7 Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system) (By similarity) D9E17_03340 ENOG4105DU1 integral membrane protein, terc D9E17_03345 ENOG4105EE0 oxidoreductase D9E17_03350 ENOG4108UB4 uncharacterized protein ygjQ D9E17_03355 ENOG4108VKG metal-dependent hydrolase D9E17_03360 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) D9E17_03365 ENOG4105R48 this blockage is overcome by subsequent expression of antitoxin HigA. Overexpression causes cleavage of a number of mRNAs in a translation-dependent fashion, suggesting this is an mRNA interferase D9E17_03370 ENOG4108Z3N Transcriptional regulator D9E17_03375 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase D9E17_03380 ENOG4107WCA isomerase D9E17_03385 ENOG4107W6W Conserved Protein D9E17_03390 ENOG4105E5D amino acid D9E17_03395 ENOG4105FK9 beta-D-galactosidase beta subunit D9E17_03400 ENOG4105CNT hydrolase family 2 D9E17_03405 ENOG4105CQ4 Transcriptional regulator D9E17_03410 ENOG4108Y51 tRNA-binding protein D9E17_03420 ENOG4107RHT methyl-accepting chemotaxis sensory transducer with Pas Pac sensor D9E17_03425 ENOG4105NTW Transcriptional regulator D9E17_03430 ENOG4105Q26 Siderophore-interacting protein D9E17_03445 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) D9E17_03450 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) D9E17_03455 ENOG4105VCC 30S ribosomal protein S21 D9E17_03465 ENOG4107QPK )-transporter D9E17_03470 ENOG4107GFK fumarate D9E17_03475 ENOG4106DSS Tartrate dehydratase subunit alpha D9E17_03480 ENOG4105EJC lysr family transcriptional regulator D9E17_03490 ENOG4107ZVW dihydroneopterin aldolase D9E17_03495 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) D9E17_03505 ENOG4106MWK domain protein D9E17_03510 ENOG4105I7R Adenylate cyclase D9E17_03535 ENOG4107S78 Band 7 protein D9E17_03540 ENOG4105PV3 Inner membrane protein yqiJ D9E17_03550 ENOG4108MY7 Fimbrial D9E17_03555 ENOG4108TTM chaperone D9E17_03565 ENOG4105H8W Fimbrial protein D9E17_03570 ENOG4105W0Z cytoplasmic protein D9E17_03585 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b D9E17_03590 ENOG4106032 Glutathionylspermidine synthase D9E17_03600 ENOG4105DFG type I secretion outer membrane protein D9E17_03605 ENOG41087AY ADP-Ribose pyrophosphatase D9E17_03610 ENOG4108SX3 cytoplasmic protein D9E17_03615 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) D9E17_03620 ENOG4105IPS esterase D9E17_03625 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) D9E17_03630 ENOG4105VRH Antibiotic biosynthesis monooxygenase D9E17_03635 ENOG4105NF4 modulator of drug activity D9E17_03640 ENOG4107DEU Inner membrane protein YgiZ D9E17_03645 ENOG4105DHQ Histidine kinase D9E17_03650 ENOG4105XJC Two component transcriptional regulator (Winged helix family D9E17_03655 ENOG4105H4F exported protein D9E17_03660 ENOG4105F4I Transcriptional regulator D9E17_03665 ENOG4105RT5 Toxic component of a toxin-antitoxin (TA) module. An mRNA interferase which has been reported to be translation- independent (PubMed 19690171, PubMed 19943910) and translation- dependent (PubMed 20041169). Cleavage has been reported to occur on either side of G in the sequence GCU (PubMed 19690171) but also after C in GC(A U) sequences (PubMed 19943910). There are only 14 genes in E.coli W3110 (and probably also MG1655) that do not have a GCU sequence and thus are resistant to the mRNA interferase activity. Overexpression causes cessation of cell growth and inhibits cell proliferation via inhibition of translation as well as increasing persister cell formation D9E17_03670 ENOG4105WJ3 XRE family Transcriptional regulator D9E17_03675 ENOG4108J59 Extracellular solute-binding protein, family 5 D9E17_03680 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) D9E17_03685 ENOG4107S7E 1-acyl-sn-glycerol-3-phosphate acyltransferase D9E17_03690 ENOG4107TZ2 Cell division protein that is required for growth during stress conditions. May be involved in protecting or stabilizing the divisomal assembly under conditions of stress (By similarity) D9E17_03695 ENOG4105CCT upf0313 protein D9E17_03705 ENOG4105ZKC Conserved Protein D9E17_03710 ENOG4105CV8 reductase D9E17_03715 ENOG4108I6A alcohol dehydrogenase D9E17_03720 ENOG4105CF7 AraC family transcriptional regulator D9E17_03725 ENOG4108K81 inner membrane protein YghB D9E17_03730 ENOG4105C28 cystathionine D9E17_03735 ENOG4105CWK Biopolymer transport protein, ExbB D9E17_03740 ENOG4108ZZF transport protein (ExbD) D9E17_03745 ENOG4105CYX Short-chain dehydrogenase reductase Sdr D9E17_03755 ENOG4105CPC Aldo Keto reductase D9E17_03765 ENOG410900S Protein of unknown function (DUF2623) D9E17_03770 ENOG4105E3S small subunit D9E17_03775 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein D9E17_03780 ENOG4105CJ5 hydrogenase 2 b cytochrome subunit D9E17_03785 ENOG4105DPX Hydrogenase, large subunit D9E17_03790 ENOG4108USZ hydrogenase D9E17_03795 ENOG4108WGS hydrogenase 2-specific chaperone D9E17_03800 ENOG4105WMM Probably plays a role in a hydrogenase nickel cofactor insertion step (By similarity) D9E17_03805 ENOG41082MF Hydrogenase assembly chaperone hypC hupF D9E17_03810 ENOG4105CYM Glutathione S-transferase D9E17_03815 ENOG4106032 Glutathionylspermidine synthase D9E17_03820 ENOG4105CJ3 phosphate transporter D9E17_03825 ENOG4108GH0 ATP-binding protein yghT D9E17_03830 ENOG4108NDC ATP-binding protein yghS D9E17_03835 ENOG4106FPV ATP-binding protein YghR D9E17_03840 ENOG4108S55 polysaccharide biosynthesis protein D9E17_03850 ENOG4108UUE Transcriptional regulator D9E17_03855 ENOG4108M8S permease YjgP YjgQ family protein D9E17_03865 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) D9E17_03870 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) D9E17_03880 ENOG4107RCI amp-dependent synthetase and ligase D9E17_03890 ENOG4108KWP DNA-binding transcriptional regulator GlcC D9E17_03895 ENOG4105CQB FAD linked oxidase domain protein D9E17_03900 ENOG4105EU8 FAD linked oxidase domain protein D9E17_03905 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) D9E17_03910 ENOG4108ZJF Glcg protein D9E17_03915 ENOG4107QP3 malate synthase g D9E17_03920 ENOG4105DAA L-lactate D9E17_03955 ENOG4107QHF type ii secretion system protein e D9E17_03970 ENOG4108UQV Membrane D9E17_03975 ENOG4105CXN decarboxylase D9E17_03980 ENOG4105EAA nucleoside D9E17_03995 ENOG4105CEN a g-specific adenine glycosylase D9E17_04005 ENOG41090ED Protein with unknown function (DUF469) D9E17_04010 ENOG4105K33 Periplasmic Protein D9E17_04015 ENOG4105HDK L-asparaginase D9E17_04020 ENOG4106MH3 alpha helix chain D9E17_04025 ENOG4105CSA Coproporphyrinogen iii oxidase D9E17_04030 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) D9E17_04040 ENOG4108VIA integral membrane protein D9E17_04045 ENOG4105DFA alanine racemase domain protein D9E17_04050 ENOG4105CZX twitching motility protein D9E17_04065 ENOG4105D7Z glutathione synthase D9E17_04070 ENOG4105QF0 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) D9E17_04075 ENOG4105RWS endonuclease I D9E17_04085 ENOG4107QNK )-transporter D9E17_04100 ENOG4105DP5 Catalyzes the biosynthesis of agmatine from arginine (By similarity) D9E17_04110 ENOG4108K0D peptidase, M48 D9E17_04115 ENOG4105CV1 Transketolase (EC 2.2.1.1) D9E17_04120 ENOG4108X7Y Mannitol-specific cryptic phosphotransferase enzyme iia D9E17_04125 ENOG4105CTS PTS system mannitol-specific D9E17_04130 ENOG4105DXH Alcohol dehydrogenase zinc-binding domain protein D9E17_04135 ENOG4108Q8A Fructose-1,6-bisphosphatase D9E17_04140 ENOG4108R4K DNA-binding, transcriptional regulator D9E17_04145 ENOG4107Z1W Fructose transport system kinase D9E17_04160 ENOG4105D2N Aldolase D9E17_04165 ENOG4105D64 Mechanosensitive ion channel D9E17_04170 ENOG4108ZUB Lysine exporter protein (Lyse ygga) D9E17_04175 ENOG4105MPN Membrane D9E17_04180 ENOG4105DEQ transcriptional regulator D9E17_04185 ENOG4105CYC Transferase D9E17_04190 ENOG4108M7F enoyl-CoA hydratase isomerase D9E17_04195 ENOG4105DJT lAO AO transport system ATPase D9E17_04200 ENOG4105D5P Methylmalonyl-coA mutase D9E17_04220 ENOG4108JQ1 Dehydrogenase D9E17_04230 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase D9E17_04250 ENOG4107RAQ aminopeptidase D9E17_04255 ENOG4105D0A hydroxylase D9E17_04260 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family D9E17_04285 ENOG4105CS2 ec 3.2.1.21 D9E17_04290 ENOG4105N5Z UPF0267 protein D9E17_04295 ENOG4108UT2 hemolysin iii D9E17_04305 ENOG4105Y75 tpr repeat protein D9E17_04310 ENOG4108YDB Toxic component of a toxin-antitoxin (TA) module. Overexpression leads to growth arrest after 5 hours, with initial elongation of cells, followed by swelling. The toxic effects are abrogated by coexpression with antitoxin CptB. Interacts with cytoskeletal proteins FtsZ and MreB D9E17_04315 ENOG41071R3 Low-potential electron donor to a number of redox enzymes (By similarity) D9E17_04320 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) D9E17_04325 ENOG4105T95 Thiol disulfide interChange protein D9E17_04330 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) D9E17_04340 ENOG4105CRK lysyL-tRNA synthetase D9E17_04360 ENOG4105C2W permease D9E17_04365 ENOG4105BZ8 glutamate synthase D9E17_04370 ENOG4108R8B oxidoreductase Fe-S subunit D9E17_04375 ENOG4105C7N Xanthine uracil vitamin C permease D9E17_04380 ENOG4107QUY Guanine deaminase D9E17_04385 ENOG4105C2W permease D9E17_04390 ENOG4105C7W Xanthine dehydrogenase D9E17_04395 ENOG410873Y FAD binding domain in molybdopterin dehydrogenase D9E17_04400 ENOG4107UUR Chlorohydrolase aminohydrolase D9E17_04405 ENOG4105BZ8 glutamate synthase D9E17_04410 ENOG4105MFX 4-diphosphocytidyl-2c-methyl-d-erythritol synthase D9E17_04415 ENOG4105MJ6 selenium-dependent hydroxylase accessory protein YqeC D9E17_04420 ENOG4107P0T Selenium-dependent molybdenum hydroxylase system protein, YqeB family D9E17_04425 ENOG4105C5B carbamate kinase D9E17_04435 ENOG4107S4Y M20 DapE family protein YgeY D9E17_04440 ENOG4107RCH Diaminopropionate ammonia-lyase D9E17_04445 ENOG4105IW6 Carbamoyltransferase D9E17_04450 ENOG4108JUB Transcriptional regulator D9E17_04455 ENOG4108UTP (2Fe-2S)-binding domain protein D9E17_04460 ENOG4108HR6 Dehydrogenase D9E17_04465 ENOG4105C7W Xanthine dehydrogenase D9E17_04470 ENOG4108K5P (LipO)protein D9E17_04485 ENOG4108SER Transposase D9E17_04495 ENOG41075IY surface presentation of antigens protein SpaP D9E17_04505 ENOG4108TN6 type iii secretion D9E17_04510 ENOG4108M6W surface presentation of antigens protein SpaS D9E17_04515 ENOG4108M6W surface presentation of antigens protein SpaS D9E17_04530 ENOG4108RC9 Type III secretion system protein D9E17_04545 ENOG4108RBT type iii secretion D9E17_04585 ENOG4108YAB Invasion protein D9E17_04615 ENOG4105FV3 D9E17_04620 ENOG4108TC1 Transcriptional regulator D9E17_04625 ENOG4105ISV protein with bipartite regulator domain D9E17_04630 ENOG4108MHD transport protein D9E17_04635 ENOG4105CHU acetyl-coa acetyltransferase D9E17_04645 ENOG4105CHR reductase D9E17_04650 ENOG4107QNK )-transporter D9E17_04660 ENOG4105RQF LysR family Transcriptional regulator D9E17_04665 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) D9E17_04670 ENOG41060NJ transcriptional regulator D9E17_04690 ENOG4105CPC Aldo Keto reductase D9E17_04695 ENOG4105SUV lipoprotein YgdR D9E17_04700 ENOG4105EE5 Membrane protein terC D9E17_04720 ENOG4108HRM phosphoenolpyruvate--protein phosphotransferase D9E17_04735 ENOG4105IPU prepilin peptidase dependent protein A D9E17_04740 ENOG4105JCS prepilin peptidase dependent protein D9E17_04745 ENOG4105SEN Protein of unknown function (DUF2509) D9E17_04750 ENOG4105RVB Prepilin peptidase dependent protein c D9E17_04755 ENOG4105DSY exodeoxyribonuclease V, gamma D9E17_04760 ENOG4107QXK peptidase D9E17_04765 ENOG4107QKA exodeoxyribonuclease V beta D9E17_04770 ENOG4107QYX exodeoxyribonuclease v alpha D9E17_04775 ENOG4107QZM n-acetylglutamate synthase D9E17_04780 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase D9E17_04800 ENOG4105CA3 membrane-bound lytic murein transglycosylase D9E17_04805 ENOG4105CUZ uba thif-type nad fad binding protein D9E17_04810 ENOG4105P9C Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity) D9E17_04815 ENOG4105C9B Cysteine desulfurase D9E17_04820 ENOG4105M5B (LipO)protein D9E17_04825 ENOG4105ETT transcriptional Regulator, LysR family D9E17_04830 ENOG4105M08 Membrane D9E17_04840 ENOG4107EDW L-fucose operon activator D9E17_04850 ENOG4105CMG Carbohydrate kinase D9E17_04860 ENOG4105EDR glucose galactose transporter D9E17_04865 ENOG4107W7X Aldolase D9E17_04870 ENOG4105C0A alcohol dehydrogenase D9E17_04880 ENOG4105EJQ L-serine dehydratase D9E17_04885 ENOG4105C44 Serine transporter D9E17_04890 ENOG4105EWT decarboxylase family D9E17_04905 ENOG4105WP7 tRNA pseudouridine synthase C D9E17_04910 ENOG4105DR9 pseudouridine synthase D9E17_04915 ENOG4105QDK Flavodoxin D9E17_04920 ENOG4105DJB Major Facilitator Superfamily D9E17_04925 ENOG4105EQX glucarate dehydratase D9E17_04930 ENOG4105BZU Histidine kinase D9E17_04935 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) D9E17_04940 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) D9E17_04945 ENOG4106A2Z transcriptional regulator antitoxin, MazE D9E17_04950 ENOG4105MZG transcriptional modulator of maze toxin, mazf D9E17_04955 ENOG4105DXN mazG family D9E17_04970 ENOG4105HA9 of methanol dehydrogenase type D9E17_04980 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) D9E17_04985 ENOG4108CWB sugar kinase ygcE D9E17_04990 ENOG4108ITV Inner membrane protein yqcE D9E17_04995 ENOG4105CHR reductase D9E17_05000 ENOG4107R3A FAD linked oxidase domain protein D9E17_05005 ENOG4105C54 Major Facilitator superfamily D9E17_05010 ENOG4106IKH Electron transfer flavoprotein D9E17_05015 ENOG4105YBM electron transfer flavoprotein subunit ygcQ D9E17_05020 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator D9E17_05025 ENOG4105WQV ferredoxin-like protein D9E17_05030 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase D9E17_05035 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase D9E17_05075 ENOG4105CYR Crispr-associated protein, cse1 family D9E17_05080 ENOG41061HK CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA) D9E17_05085 ENOG41060M0 Crispr-associated protein, cse4 family D9E17_05090 ENOG4108VWQ crispr-associated protein D9E17_05095 ENOG4108Y7V CRISPR-associated protein, Cse3 family D9E17_05100 ENOG4105TZK CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. May be involved in the integration of spacer DNA into the CRISPR cassette (By similarity) D9E17_05105 ENOG4105PWE CRISPR-associated protein cas2 D9E17_05110 ENOG4108MXK alkaline phosphatase isozyme conversion D9E17_05130 ENOG4105N0Z inner membrane protein ygbE D9E17_05165 ENOG4108K5P (LipO)protein D9E17_05170 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) D9E17_05175 ENOG4105C6Z Gluconate D9E17_05180 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) D9E17_05185 ENOG4105FB2 class II Aldolase D9E17_05190 ENOG4105G63 Type III effector Hrp-dependent D9E17_05195 ENOG4105ZXK Dehydrogenase D9E17_05200 ENOG4105MVE transcriptional regulator D9E17_05205 ENOG4105MEW serine threonine protein phosphatase D9E17_05210 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) D9E17_05220 ENOG4105VXR cytoplasmic protein D9E17_05225 ENOG4108JUA Transcriptional regulator D9E17_05230 ENOG4105C45 hydrogenase expression formation protein (HypE) D9E17_05235 ENOG4105CQS hydrogenase expression formation protein HypD D9E17_05240 ENOG41083WG hydrogenase assembly chaperone D9E17_05245 ENOG4107RSS Hydrogenase accessory protein HypB D9E17_05250 ENOG410816D Probably plays a role in a hydrogenase nickel cofactor insertion step (By similarity) D9E17_05260 ENOG4108VRC Formate hydrogenlyase regulatory protein hycA D9E17_05265 ENOG4108MFN small subunit of hydrogenase-3, iron-sulfur protein (part of formate hydrogenlyase (FHL) complex) D9E17_05270 ENOG4107R30 NADH dehydrogenase D9E17_05275 ENOG4107TDF Formate hydrogenlyase subunit 4 D9E17_05280 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) D9E17_05285 ENOG4108RG7 formate hydrogenlyase complex iron-sulfur subunit D9E17_05290 ENOG4105C47 NADH ubiquinone oxidoreductase 20 kda subunit D9E17_05295 ENOG4105I6X formate hydrogenlyase maturation D9E17_05300 ENOG4108MG9 hydrogenase 3 maturation protease D9E17_05305 ENOG4105CS2 ec 3.2.1.21 D9E17_05310 ENOG4105C5Y PTS System D9E17_05315 ENOG4105DDV Transcriptional regulator (LacI family D9E17_05320 ENOG4108RC0 Electron transport protein D9E17_05325 ENOG4105C8H hydrogenase maturation protein Hypf D9E17_05345 ENOG4105C2X Arabinose 5-phosphate isomerase D9E17_05350 ENOG410804X Transcriptional regulator D9E17_05355 ENOG4105J92 DNA-binding transcriptional activator GutM D9E17_05360 ENOG4107QMF Sorbitol-6-phosphate dehydrogenase D9E17_05365 ENOG4105VI0 Pts system, glucitol sorbitol-specific D9E17_05370 ENOG4105DZY Pts system, glucitol sorbitol-specific D9E17_05375 ENOG410787A Pts system, glucitol sorbitol-specific D9E17_05380 ENOG4105CVE Lytic murein transglycosylase D9E17_05385 ENOG4107TH8 cina domain protein D9E17_05405 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) D9E17_05435 ENOG4107VXZ Hydrolase D9E17_05440 ENOG4105W39 Membrane D9E17_05455 ENOG4105C0R drug resistance transporter emrb qaca subfamily D9E17_05460 ENOG4105CW7 secretion protein, HlyD family D9E17_05465 ENOG4105NTK Transcriptional repressor Mpra D9E17_05470 ENOG4105ZED uncharacterized protein ygaH D9E17_05475 ENOG4108UMN azlc family D9E17_05485 ENOG4105GIJ Glycine betaine D9E17_05490 ENOG4108HQS Glycine betaine D9E17_05495 ENOG4108IJ7 Glycine betaine D9E17_05500 ENOG4107R25 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) D9E17_05505 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) D9E17_05510 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) D9E17_05515 ENOG4105WAZ (Glutaredoxin-like protein) NrdH D9E17_05520 ENOG4108ZQZ Bacterial protein of unknown function (DUF883) D9E17_05525 ENOG4108WMJ Protein of unknown function (DUF2002) D9E17_05530 ENOG4108RNS Exports L-alanine (By similarity) D9E17_05535 ENOG4108X73 DNA- binding protein D9E17_05540 ENOG4108V62 Rhodanese domain protein D9E17_05545 ENOG41080HT Transcriptional regulator, arsr family D9E17_05550 ENOG4105VPI YqaE family transport protein D9E17_05555 ENOG4109066 lysm domain bon superfamily protein D9E17_05560 ENOG4108PVQ transcriptional regulator D9E17_05565 ENOG4105C85 amino acid D9E17_05570 ENOG4108JPW Aminotransferase D9E17_05575 ENOG4105C26 Dehydrogenase D9E17_05580 ENOG4105D5U fad dependent oxidoreductase D9E17_05700 ENOG4105DZR Type I site-specific deoxyribonuclease D9E17_05710 ENOG4105CVR type I restriction-modification system D9E17_05720 ENOG4105FA0 parb-like partition protein D9E17_05730 ENOG4105DFP Integrase D9E17_05745 ENOG4108Z1B Cyclase dehydrase D9E17_05750 ENOG4105VDB UPF0125 protein D9E17_05755 ENOG4105YRI Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) D9E17_05760 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) D9E17_05775 ENOG4108JU6 CBS domain protein D9E17_05780 ENOG4106KVJ cytochrome C assembly protein D9E17_05785 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY D9E17_05810 ENOG41090EK ompa motb domain protein D9E17_05815 ENOG4108KHX Diguanylate cyclase D9E17_05820 ENOG4108WS1 D9E17_05825 ENOG4105QP9 Protein of unknown function (DUF2799) D9E17_05830 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) D9E17_05835 ENOG4105EHE chorismate mutase- prephenate dehydrogenase D9E17_05840 ENOG4105CQC Prephenate dehydratase D9E17_05850 ENOG4108WPH sigma 54 modulation protein ribosomal protein S30EA D9E17_05855 ENOG4106SNF Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane D9E17_05860 ENOG4105C34 Pseudouridine synthase D9E17_05865 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase D9E17_05870 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit D9E17_05895 ENOG4105CSH Transporter D9E17_05900 ENOG4105T42 (LipO)protein D9E17_05905 ENOG4105JIM Phosphatidylserine synthase D9E17_05910 ENOG4105CD5 CoA-binding domain protein D9E17_05915 ENOG4106IUH DTW domain containing protein D9E17_05920 ENOG4105K63 Thioredoxin D9E17_05925 ENOG4105EIB trna rrna methyltransferase D9E17_05945 ENOG41090KR LysR family transcriptional Regulator D9E17_05950 ENOG4105C1J atp-dependent rna helicase D9E17_05955 ENOG4107S47 Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC) (By similarity) D9E17_05960 ENOG4108IYU L-aspartate oxidase D9E17_05970 ENOG4105EMN RNA polymerase sigma factor D9E17_05975 ENOG41069PW sigma-e factor negative regulatory protein D9E17_05980 ENOG4105VQK sigma E regulatory protein, MucB RseB D9E17_05985 ENOG4105WMJ Positive regulator of sigma E, RseC MucC D9E17_05995 ENOG4105C3F Signal peptidase i D9E17_06015 ENOG4105CSZ Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity) D9E17_06030 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding D9E17_06035 ENOG4106G6Q Transcriptional regulator D9E17_06040 ENOG4105HYY HAD superfamily (Subfamily IF) hydrolase, YfhB D9E17_06045 ENOG4108Z6B deaminase D9E17_06060 ENOG4107WP9 Histidine kinase D9E17_06065 ENOG4108SKK alpha helix protein D9E17_06070 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family D9E17_06075 ENOG4108YZA Nitrogen regulatory protein pii D9E17_06080 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) D9E17_06090 ENOG4108NZE NAGC-like transcriptional regulator D9E17_06100 ENOG4105FCA ABC transporter periplasmic-binding protein YphF D9E17_06105 ENOG4108F37 ATP-binding component of a transport system D9E17_06110 ENOG4105CNN ABC, transporter D9E17_06115 ENOG4105CPQ Dehydrogenase D9E17_06120 ENOG4108ZKT aldose 1-epimerase D9E17_06125 ENOG4108SB3 DoxX Family D9E17_06150 ENOG4105FUY alpha subunit D9E17_06155 ENOG4108W5M transcriptional regulator D9E17_06160 ENOG4105D8G Major Facilitator superfamily D9E17_06165 ENOG4108MN2 Stationary phase inducible protein CsiE D9E17_06170 ENOG4107XM9 (LipO)protein D9E17_06195 ENOG4107XTC May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins D9E17_06215 ENOG4108ZIT Ferredoxin, 2FE-2S D9E17_06220 ENOG4105WVQ Fe-S assembly protein IscX D9E17_06230 ENOG4105YYA enhanced serine sensitivity protein SseB D9E17_06235 ENOG4105KHC sulfurtransferase D9E17_06240 ENOG4105DN3 alpha-2-macroglobulin domain protein D9E17_06245 ENOG4108JQB penicillin-binding protein 1C D9E17_06275 ENOG4105N21 Membrane D9E17_06290 ENOG4105VPD cellular component movement D9E17_06300 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) D9E17_06310 ENOG41066DY Membrane D9E17_06315 ENOG4108ZMA Outer membrane lipoprotein D9E17_06320 ENOG41062G3 Protein of unknown function (DUF2633) D9E17_06325 ENOG4105BZU Histidine kinase D9E17_06330 ENOG4105C9X ppx gppa phosphatase D9E17_06335 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) D9E17_06340 ENOG4108V3E phosphoribosylglycinamide formyltransferase D9E17_06355 ENOG4105C2W permease D9E17_06365 ENOG4105K89 arsenate reductase D9E17_06370 ENOG4105ERG peptidase m48, ste24p D9E17_06375 ENOG4105C02 permease D9E17_06380 ENOG4105TMB Formate nitrite transporter D9E17_06385 ENOG4108JUA Transcriptional regulator D9E17_06390 ENOG4105I6X formate hydrogenlyase maturation D9E17_06395 ENOG4105C47 NADH ubiquinone oxidoreductase 20 kda subunit D9E17_06405 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) D9E17_06410 ENOG4108JPZ Monovalent cation H antiporter subunit D D9E17_06415 ENOG4107WQX hydrogenase 4 membrane subunit D9E17_06420 ENOG4105D65 subunit l D9E17_06425 ENOG4105D65 subunit l D9E17_06430 ENOG4107TDF Formate hydrogenlyase subunit 4 D9E17_06440 ENOG4108MFN small subunit of hydrogenase-3, iron-sulfur protein (part of formate hydrogenlyase (FHL) complex) D9E17_06445 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen D9E17_06450 ENOG4105RH4 Glycine cleavage system transcriptional repressor D9E17_06460 ENOG4107EG0 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) D9E17_06470 ENOG4105CGZ zinc metallopeptidase D9E17_06480 ENOG4106KED esterase YpfH D9E17_06495 ENOG4105KUZ arsenate reductase D9E17_06505 ENOG4105BZS acriflavin resistance protein D9E17_06510 ENOG4105BZU Histidine kinase D9E17_06515 ENOG4105BZ8 glutamate synthase D9E17_06520 ENOG4107VIJ nudix hydrolase D9E17_06525 ENOG4108PVD exported protein D9E17_06530 ENOG4105CV1 Transketolase (EC 2.2.1.1) D9E17_06535 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) D9E17_06540 ENOG4105C6K Malic enzyme D9E17_06545 ENOG4108VJN May be involved in the formation of a specific microcompartment in the cell in which the metabolism of potentially toxic by-products takes place D9E17_06550 ENOG4106S4J ethanolamine utilization protein EutP D9E17_06555 ENOG4105NDK ethanolamine utilization protein D9E17_06560 ENOG4108PFF ethanolamine utilization cobalamin adenosyltransferase D9E17_06565 ENOG4107WUY phosphate acetyltransferase D9E17_06570 ENOG4105KNY Microcompartments protein D9E17_06575 ENOG4105WVM ethanolamine utilization protein EutN carboxysome structural protein Ccml D9E17_06580 ENOG4108EKI Dehydrogenase D9E17_06585 ENOG4107RWI ethanolamine utilization protein eutJ D9E17_06590 ENOG4105C0A alcohol dehydrogenase D9E17_06595 ENOG4105ENY Ethanolamine utilization protein eutH D9E17_06600 ENOG4105DYY Reactivating factor for ethanolamine ammonia lyase D9E17_06605 ENOG4105CPD ethanolamine ammonia-lyase D9E17_06615 ENOG4106D67 ethanolamine utilization protein D9E17_06620 ENOG4108X49 Ethanolamine utilization protein EutK D9E17_06625 ENOG4108K3Z AraC family transcriptional regulator D9E17_06635 ENOG4108KNB n-acetylmuramoyl-l-alanine amidase D9E17_06640 ENOG4108R6G acetyltransferase D9E17_06645 ENOG4105QZU Inner membrane protein YfeZ D9E17_06650 ENOG4105E7K (LipO)protein D9E17_06655 ENOG4105EZR dyp-type peroxidase family protein D9E17_06660 ENOG4107S1E Beta-lactamase D9E17_06665 ENOG4105C5Y PTS System D9E17_06675 ENOG4108PSC Represses the expression of the murPQ operon involved in the uptake and degradation of N-acetylmuramic acid (MurNAc). Binds to two adjacent inverted repeats within the operator region. MurNAc 6-phosphate, the substrate of MurQ, is the specific inducer that weakens binding of MurR to the operator (By similarity) D9E17_06680 ENOG4105I7Z Short-chain dehydrogenase reductase Sdr D9E17_06685 ENOG4108J2H Sulfate ABC transporter periplasmic sulfate-binding protein D9E17_06690 ENOG4108I5D sulfate abc transporter D9E17_06695 ENOG4105ECW sulfate abc transporter D9E17_06700 ENOG4108IJ6 ABC transporter D9E17_06705 ENOG4105C6T cysteine synthase D9E17_06710 ENOG4105WEC Molybdate metabolism regulator D9E17_06715 ENOG4105M0Y D9E17_06725 ENOG4105C5Y PTS System D9E17_06730 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) D9E17_06735 ENOG4105KZ7 phosphocarrier protein hpr D9E17_06740 ENOG4105C6T cysteine synthase D9E17_06760 ENOG4105VRT cytoplasmic protein D9E17_06765 ENOG4105DHU Bile acid D9E17_06770 ENOG4108M0I Transcriptional regulator D9E17_06780 ENOG4107U5R The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity) D9E17_06785 ENOG4105EAA nucleoside D9E17_06795 ENOG4105CN8 Transcriptional regulator D9E17_06830 ENOG4105GXM Putative transcription regulator (DUF1323) D9E17_06835 ENOG4105HZG regulatoR D9E17_06850 ENOG4108KMM Diguanylate cyclase D9E17_06855 ENOG4105D9N nucleoside D9E17_06865 ENOG4109076 Conserved Protein D9E17_06870 ENOG4105VCT ion-transport protein YfeO D9E17_06880 ENOG4105R6B The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane (By similarity) D9E17_06885 ENOG410863U PTS System D9E17_06890 ENOG4105DC7 peptidase M24 D9E17_06895 ENOG4105CN9 Peptidase m42 family protein D9E17_06900 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) D9E17_06905 ENOG4108CIP transcriptional regulator D9E17_06910 ENOG4105DY9 regulatoR D9E17_06915 ENOG4108HRK Histidine kinase D9E17_06920 ENOG4105CHM Aminotransferase D9E17_06930 ENOG4105D1S lipid A biosynthesis D9E17_06935 ENOG4105W9M Membrane D9E17_06945 ENOG4108V08 YfdX protein D9E17_06955 ENOG4105CFN oxalyl-CoA decarboxylase D9E17_06960 ENOG4108N2Y auxin Efflux D9E17_06965 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F D9E17_06970 ENOG4105BZU Histidine kinase D9E17_06975 ENOG4108WQH regulatoR D9E17_06980 ENOG4105CW7 secretion protein, HlyD family D9E17_06985 ENOG4105C0R drug resistance transporter emrb qaca subfamily D9E17_06995 ENOG4105C6Z Gluconate D9E17_07000 ENOG4105W8I Transcriptional regulator D9E17_07010 ENOG4105S64 Formate nitrite transporter D9E17_07015 ENOG410903C (LipO)protein D9E17_07025 ENOG4105CKF membrane protein involved in aromatic hydrocarbon degradation D9E17_07030 ENOG4105KZW UPF0381 protein D9E17_07045 ENOG4108BY2 phosphohistidine phosphatase D9E17_07055 ENOG4106PG1 outer membrane usher protein D9E17_07060 ENOG4108FZ9 Chaperone D9E17_07065 ENOG4105NEV Fimbrial D9E17_07070 ENOG4105UGQ Fimbrial D9E17_07075 ENOG4105US4 fimbrial-like protein yfcP D9E17_07105 ENOG4105EJ9 Membrane D9E17_07110 ENOG4108BPE -transporting atpase D9E17_07115 ENOG4105MH2 YfcL protein D9E17_07125 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) D9E17_07130 ENOG4105F9N Major Facilitator Superfamily D9E17_07135 ENOG4106WZ1 flagella biosynthesis regulator D9E17_07145 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) D9E17_07155 ENOG4105DQR SNARE associated Golgi D9E17_07165 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase D9E17_07170 ENOG4108S3P Sporulation domain protein D9E17_07175 ENOG4105E96 Colicin v production protein D9E17_07180 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase D9E17_07185 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase D9E17_07190 ENOG4105E89 ABC transporter D9E17_07195 ENOG4105E89 ABC transporter D9E17_07200 ENOG4105DSP amino acid AbC transporter D9E17_07205 ENOG4106YG3 ABC transporter D9E17_07210 ENOG4108JEH abc transporter atp-binding protein D9E17_07220 ENOG4105ECP epimerase D9E17_07225 ENOG4105KKP D-erythro-7,8-dihydroneopterin triphosphate 2'-epimerase D9E17_07230 ENOG4105CYM Glutathione S-transferase D9E17_07235 ENOG4108SHQ Glutathione S-transferase D9E17_07240 ENOG4108RE9 Phosphodiesterase D9E17_07245 ENOG4105PTV Nudix Hydrolase D9E17_07250 ENOG4105CSX c4-dicarboxylate anaerobic carrier D9E17_07255 ENOG4105C6K Malic enzyme D9E17_07260 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) D9E17_07275 ENOG4105EVE HAD-superfamily hydrolase subfamily IA variant 3 D9E17_07280 ENOG4107QWE )-transporter D9E17_07290 ENOG4105CHM Aminotransferase D9E17_07295 ENOG4107NQ8 LysR family Transcriptional regulator D9E17_07315 ENOG4105GKE subunit e D9E17_07320 ENOG4107QIZ NADH dehydrogenase D9E17_07325 ENOG4107R0R NADH dehydrogenase subunit g D9E17_07335 ENOG4105P3U NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) D9E17_07340 ENOG4107UFS subunit j D9E17_07345 ENOG41080EA NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) D9E17_07350 ENOG4105D65 subunit l D9E17_07355 ENOG4105C8S subunit m D9E17_07365 ENOG4105GDX Domain of unknown function (DUF1877) D9E17_07385 ENOG4107YB6 acetyltransferase, (GNAT) family D9E17_07390 ENOG4105TNS Conserved Protein D9E17_07395 ENOG4105E4F Isochorismate synthase D9E17_07410 ENOG4108IPT Naphthoate synthase D9E17_07420 ENOG4105CEY Amp-dependent synthetase and ligase D9E17_07425 ENOG4106GZG polymyxin resistance protein B D9E17_07440 ENOG4105SA9 Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity) D9E17_07445 ENOG4105F73 Catalyzes the deformylation of 4-deoxy-4-formamido-L- arabinose-phosphoundecaprenol to 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity) D9E17_07475 ENOG4108UII YfaZ family D9E17_07485 ENOG4107258 Transcriptional regulator D9E17_07505 ENOG4105DNE Transposase D9E17_07510 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) D9E17_07520 ENOG4107R5Y anaerobic glycerol-3-phosphate dehydrogenase, subunit A D9E17_07525 ENOG4105CXY transporter D9E17_07530 ENOG4106MZZ glycerophosphoryl diester phosphodiesterase D9E17_07540 ENOG4105FQR PH-inducible protein involved in stress response D9E17_07545 ENOG4105XPH Ferredoxin D9E17_07550 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) D9E17_07555 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) D9E17_07560 ENOG4107GHC outer membrane autotransporter D9E17_07570 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) D9E17_07580 ENOG4107S52 alpha-2-macroglobulin domain protein D9E17_07585 ENOG41081SK signal peptide protein D9E17_07590 ENOG4105EDV vault protein D9E17_07595 ENOG4105BZU Histidine kinase D9E17_07600 ENOG41068CG regulatoR D9E17_07605 ENOG4105E3G Phosphotransfer intermediate protein in two-component regulatory system with RcsBC D9E17_07610 ENOG4105FCK Membrane D9E17_07615 ENOG4105CJ2 (LipO)protein D9E17_07620 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) D9E17_07625 ENOG4105CF1 Alkylated DNA repair protein D9E17_07630 ENOG4105IBP Cyclic peptide transporter D9E17_07645 ENOG4108ZNS ferredoxin-type protein NapF D9E17_07650 ENOG41061Q0 Assembly protein for periplasmic nitrate reductase D9E17_07660 ENOG4108BGM Quinol dehydrogenase periplasmic component D9E17_07665 ENOG4105GXZ Ferredoxin-type protein NapH D9E17_07670 ENOG4108ZMS Electron transfer subunit of the periplasmic nitrate reductase complex NapAB (By similarity) D9E17_07675 ENOG4105CUW cytochrome C-TYPE protein D9E17_07685 ENOG4105CA5 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes (By similarity) D9E17_07690 ENOG41060IM Heme exporter protein D9E17_07695 ENOG4105X3C heme exporter protein D9E17_07705 ENOG4105DA4 cytochrome c-type biogenesis protein D9E17_07710 ENOG4107QX9 Thiol disulfide interChange protein D9E17_07715 ENOG4105KWW Biogenesis protein D9E17_07720 ENOG4105WH1 Two component transcriptional regulator luxr family D9E17_07735 ENOG4105E68 Sulfatase D9E17_07755 ENOG4105CFI type iii restriction protein res subunit D9E17_07760 ENOG4105I08 Pseudouridine synthase D9E17_07765 ENOG4105C2C drug resistance transporter, Bcr CflA D9E17_07770 ENOG4105HG6 D9E17_07775 ENOG4108JQ5 ABC transporter D9E17_07780 ENOG4108IYQ Binding-protein-dependent transport systems inner membrane component D9E17_07785 ENOG4108I5X binding-protein-dependent transport systems inner membrane Component D9E17_07790 ENOG4105E43 Extracellular solute-binding protein, family 5 D9E17_07795 ENOG4105CXC rtn protein D9E17_07800 ENOG4107TT5 NLP P60 protein D9E17_07805 ENOG41076MN Phosphoesterase, PA-phosphatase related D9E17_07810 ENOG4105CKI cobalamin synthesis protein D9E17_07815 ENOG4105DEI Mannitol dehydrogenase D9E17_07825 ENOG4105KRS Proteinase inhibitor D9E17_07830 ENOG4105S8Q sugar efflux transporter D9E17_07835 ENOG4105DTZ bifunctional PTS system fructose-specific transporter subunit IIA HPr protein D9E17_07840 ENOG4105DE4 1-phosphofructokinase D9E17_07845 ENOG4105DM4 PTS System D9E17_07850 ENOG4105DD7 kinase (PfkB family D9E17_07855 ENOG4105D53 Catalyzes the hydrolysis of pseudouridine 5'-phosphate (PsiMP) to ribose 5-phosphate and uracil (By similarity) D9E17_07860 ENOG4105D9N nucleoside D9E17_07865 ENOG4108Y4K DNA-binding transcriptional activator D9E17_07875 ENOG4105D9N nucleoside D9E17_07880 ENOG4105DD7 kinase (PfkB family D9E17_07890 ENOG4105HMI Membrane D9E17_07895 ENOG4105DUM transcriptional regulator, lysR family D9E17_07900 ENOG4108IQI permease D9E17_07905 ENOG4105D05 Receptor D9E17_07910 ENOG4105C4W S-formylglutathione hydrolase D9E17_07920 ENOG4105DHF Membrane D9E17_07925 ENOG41060NJ transcriptional regulator D9E17_07930 ENOG4105EMA Periplasmic binding protein LacI transcriptional regulator D9E17_07935 ENOG4105C2J ABC transporter D9E17_07940 ENOG4108HWV )-transporter D9E17_07945 ENOG4107SJI Dehydrogenase D9E17_07950 ENOG4105BZ8 glutamate synthase D9E17_07955 ENOG4105Y9N Membrane D9E17_07960 ENOG4107GZ4 SanA protein D9E17_07970 ENOG41067MG lrgb family D9E17_07980 ENOG4105FBT Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity) D9E17_07990 ENOG4105ETP RND efflux system, outer membrane lipoprotein D9E17_07995 ENOG4105H9W Short-chain dehydrogenase reductase Sdr D9E17_08000 ENOG4105KHU inner membrane protein YohD D9E17_08005 ENOG41069YE inner membrane protein yohC D9E17_08010 ENOG41061WM D-Alanyl-D-Alanine D9E17_08015 ENOG4105CXG d-lactate dehydrogenase D9E17_08020 ENOG4107QK4 glycoside hydrolase, family 3 domain protein D9E17_08025 ENOG4107SI7 Substrate-binding region of abc-type glycine betaine transport system D9E17_08030 ENOG4107T5X Binding-protein-dependent transport systems, inner membrane component D9E17_08035 ENOG4108IJ8 ABC transporter D9E17_08040 ENOG4105WJV Binding-protein-dependent transport systems, inner membrane component D9E17_08050 ENOG4108XDN Transcriptional regulator D9E17_08055 ENOG4108HRK Histidine kinase D9E17_08060 ENOG4108NEV two component transcriptional regulator, LytTR family D9E17_08065 ENOG4108W15 Protein of unknown function (DUF1456) D9E17_08070 ENOG4108YCW (LipO)protein D9E17_08075 ENOG410903U zinc ion binding D9E17_08080 ENOG4105DEG Vwa containing coxe family protein D9E17_08085 ENOG4105RD5 D9E17_08090 ENOG4105KKX ATPase associated with various cellular activities aaa_5 D9E17_08100 ENOG4108KDT Molybdate metabolism regulator D9E17_08105 ENOG4108KDT Molybdate metabolism regulator D9E17_08115 ENOG4105D1F ATP-binding protein D9E17_08120 ENOG41067AK Protein of unknown function (DUF2574) D9E17_08125 ENOG41063W2 Fimbrial protein D9E17_08140 ENOG4105CW0 outer membrane usher protein D9E17_08145 ENOG410662B Type-1 fimbrial protein D9E17_08150 ENOG4108Z1S Influences nickel and cobalt homeostasis. May act by modulating RcnA-mediated export of these ions to avoid excess efflux. Not involved in nickel import and does not bind nickel or cobalt ions directly D9E17_08155 ENOG41061MD high-affinity nickel-transporter D9E17_08170 ENOG4105DWF phosphomethylpyrimidine kinase D9E17_08175 ENOG4108UQ1 hydrolase, family 25 D9E17_08180 ENOG4105FDP GntR family transcriptional regulator D9E17_08185 ENOG4108TFM Kinase, PfkB family D9E17_08190 ENOG4108KD5 ADP-ribosylation crystallin J1 D9E17_08195 ENOG4105EAA nucleoside D9E17_08200 ENOG4105EIE fructose-bisphosphate aldolase D9E17_08230 ENOG4105DT3 PTS system, galactitol-specific IIc component D9E17_08235 ENOG4107WTH Galactitol-1-phosphate dehydrogenase D9E17_08250 ENOG41076Z6 Uncharacterized protein yegR D9E17_08260 ENOG4105CFP Peptidase U32 D9E17_08270 ENOG4105KWI UPF0339 protein D9E17_08275 ENOG4105E3W Two component transcriptional regulator (Winged helix family D9E17_08280 ENOG4105EB3 Histidine kinase D9E17_08320 ENOG4108M24 von Willebrand factor, type A D9E17_08330 ENOG4106E1W protein with protein kinase and helix-hairpin-helix DNA-binding D9E17_08335 ENOG4105R8A Heat shock protein D9E17_08340 ENOG4105D03 DNA-3-methyladenine glycosylase II D9E17_08345 ENOG4105BZU Histidine kinase D9E17_08350 ENOG4105DBI uridine monophosphokinase D9E17_08360 ENOG4108GAE asmA family D9E17_08365 ENOG4105EE5 Membrane protein terC D9E17_08370 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase D9E17_08375 ENOG4105MH5 phosphoesterase PA-phosphatase related protein D9E17_08385 ENOG4108MRJ D9E17_08390 ENOG4105DAY polysaccharide export protein D9E17_08450 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) D9E17_08500 ENOG4105EY8 ABC transporter D9E17_08510 ENOG4108TJN glycosyl transferase group 1 D9E17_08515 ENOG4107UU3 sucrose-phosphate synthase (EC 2.4.1.14) D9E17_08525 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase D9E17_08540 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) D9E17_08545 ENOG4105ECC imidazole-glycerol-phosphate dehydratase D9E17_08570 ENOG4105VTW prevent-host-death family D9E17_08575 ENOG4105KRQ Addiction module toxin, Txe YoeB family D9E17_08580 ENOG4108535 NAD dependent epimerase/dehydratase family D9E17_08585 ENOG4105EQ1 Transcriptional regulator D9E17_08595 ENOG4105CUB amino acid D9E17_08600 ENOG4105CUC YeeE YedE family protein D9E17_08610 ENOG4105CJB Exodeoxyribonuclease I D9E17_08615 ENOG4105DZ1 carboxypeptidase D9E17_08620 ENOG4108S5C Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell (By similarity) D9E17_08625 ENOG4105DR8 Membrane D9E17_08650 ENOG4105MAW Antitoxin component of a toxin-antitoxin (TA) module. Labile antitoxin that counteracts the effect of the CbtA (YeeV) toxin. It does not bind to the cognate toxin but instead binds to MreB and FtsZ (the toxin targets), enhancing their polymerization by forming higher-order bundles D9E17_08655 ENOG4106WJE Protein of unknown function (DUF987) D9E17_08660 ENOG4108YGG dna repair protein D9E17_08665 ENOG4105MFG Antirestriction protein D9E17_08675 ENOG4105KF5 hemolysin expression-modulating protein D9E17_08730 ENOG4108YZT Adenosylcobinamide kinase D9E17_08745 ENOG4108PXI ErfK YbiS YcfS YnhG D9E17_08755 ENOG4106P55 Transcriptional regulator D9E17_08760 ENOG4107R11 Transcriptional regulator D9E17_08770 ENOG4105UQX Mate efflux family protein D9E17_08780 ENOG4105CDY transcriptional regulatory protein D9E17_08785 ENOG4105FYV Amp nucleosidase D9E17_08790 ENOG4105CSH Transporter D9E17_08800 ENOG4105TNG K13735 adhesin invasin D9E17_08805 ENOG4105TNG K13735 adhesin invasin D9E17_08810 ENOG4105TNG K13735 adhesin invasin D9E17_08815 ENOG4105TNG K13735 adhesin invasin D9E17_08820 ENOG4107ZSV Receptor D9E17_08825 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase D9E17_08845 ENOG4105C0W non-ribosomal peptide synthetase D9E17_08860 ENOG4105BZ1 (ABC) transporter D9E17_08865 ENOG4105EYM Major Facilitator superfamily D9E17_08885 ENOG4105EXZ Involved in the regulation of ptsG expression by binding and inactivating Mlc (By similarity) D9E17_08895 ENOG4108MEK Metal-binding protein YodA D9E17_08900 ENOG4105DQ2 Is probably involved in the electron transfer between its heme and the molybdenum cofactor of the reductase catalytic subunit YedY (By similarity) D9E17_08905 ENOG4105CCD The exact function is not known. Can catalyze the reduction of a variety of substrates like dimethyl sulfoxide, trimethylamine N-oxide, phenylmethyl sulfoxide and L-methionine sulfoxide. Cannot reduce cyclic N-oxides. Shows no activity as sulfite oxidase (By similarity) D9E17_08910 ENOG4105VT2 5-hydroxyisourate hydrolase D9E17_08915 ENOG4105CK6 Two component transcriptional regulator (Winged helix family D9E17_08920 ENOG4107ZY3 Histidine kinase D9E17_08935 ENOG4105ZIT Porin Gram-negative type D9E17_08945 ENOG4105Y0K Inner membrane protein YedR D9E17_08950 ENOG4105EST Metal Dependent Phosphohydrolase D9E17_08955 ENOG4105DVF Cytosine-specific methyltransferase D9E17_08960 ENOG41090BB DNA mismatch endonuclease (vsr) D9E17_08965 ENOG4105FDR Membrane D9E17_08970 ENOG4105CKW Inner membrane protein yedI D9E17_08975 ENOG4105VNZ cytoplasmic protein D9E17_08990 ENOG4105YX3 cellular response to acidity D9E17_09005 ENOG4107TKS colanic acid capsular biosynthesis activation protein A D9E17_09010 ENOG4105D19 Role in flagellar biosynthesis (By similarity) D9E17_09015 ENOG4105VS8 Flagellar biosynthetic protein fliq D9E17_09020 ENOG4105CN7 Flagellar biosynthetic protein FliP D9E17_09025 ENOG4105K0P flagellar biosynthesis protein D9E17_09030 ENOG4105DD5 Flagellar motor switch protein D9E17_09035 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) D9E17_09040 ENOG4107ZI8 flagellar basal body-associated protein flil D9E17_09045 ENOG4105WF4 Flagellar hook-length control protein D9E17_09050 ENOG4105GSA Flagellar export protein flij D9E17_09055 ENOG4108JIR Flagellum-specific ATP synthase D9E17_09060 ENOG41090PJ Flagellar assembly protein D9E17_09065 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) D9E17_09070 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) D9E17_09085 ENOG4108RAV Conserved protein D9E17_09090 ENOG4105KSU Redox protein D9E17_09095 ENOG41066VF YeeE YedE family protein D9E17_09100 ENOG4108W9D (LipO)protein D9E17_09105 ENOG4105E5K Alpha-amylase D9E17_09115 ENOG4105MQ3 flagellar protein FliS D9E17_09120 ENOG4105DTS flagellar hook-associated D9E17_09140 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) D9E17_09145 ENOG4108M9K flagella biosynthesis protein FliZ D9E17_09150 ENOG4105EAB amino acid AbC transporter D9E17_09160 ENOG4105E5Q amino acid AbC transporter D9E17_09165 ENOG4105CDA abc transporter atp-binding protein D9E17_09170 ENOG4105VJY transcriptional regulator D9E17_09175 ENOG4105XVG cytoplasmic protein D9E17_09185 ENOG4105WH1 Two component transcriptional regulator luxr family D9E17_09195 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase D9E17_09215 ENOG4106RHG Yeca family D9E17_09220 ENOG4105E0U tyrosine-specific transport protein D9E17_09225 ENOG4105VVZ metal-binding protein D9E17_09230 ENOG41090A1 ferritin D9E17_09235 ENOG4105P23 (LipO)protein D9E17_09250 ENOG4105N4N Protein of unknown function (DUF2766) D9E17_09255 ENOG4108UEC Ferritin-like protein D9E17_09260 ENOG4105DMK Periplasmic binding protein LacI transcriptional regulator D9E17_09265 ENOG4105C2J ABC transporter D9E17_09270 ENOG4105CNN ABC, transporter D9E17_09275 ENOG4108K4C ec 3.1.3.12 D9E17_09285 ENOG4108VA4 Universal stress protein D9E17_09295 ENOG4106CIA Functions in complex with FlhD as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region D9E17_09300 ENOG4107RD7 Flagellar Motor Protein, MotA D9E17_09305 ENOG4105ER2 Ompa motb domain protein D9E17_09310 ENOG4105CBS Chea signal transduction histidine kinase D9E17_09320 ENOG4105C8Q Methyl-accepting chemotaxis D9E17_09330 ENOG4105BZU Histidine kinase D9E17_09335 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) D9E17_09340 ENOG4108VYJ response regulator receiver protein D9E17_09345 ENOG4108KCC Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P) (By similarity) D9E17_09350 ENOG4105D00 flagellar biosynthetic protein flhB D9E17_09355 ENOG4105D7B Flagellar biosynthesis protein flha D9E17_09360 ENOG4105W13 flagellar protein D9E17_09370 ENOG4105C75 arginyL-tRNA synthetase D9E17_09375 ENOG4106ZCM YecM protein D9E17_09385 ENOG4105CUW cytochrome C-TYPE protein D9E17_09390 ENOG4107QY8 reductase D9E17_09405 ENOG4105WJG Glutathione D9E17_09410 ENOG41081XQ Conserved Protein D9E17_09440 ENOG4105MPK DNA polymerase III subunit theta D9E17_09495 ENOG4105D3W isochorismatase D9E17_09505 ENOG4108TIT dATP pyrophosphohydrolase D9E17_09510 ENOG4105CDY transcriptional regulatory protein D9E17_09520 ENOG4107S01 Repressor protein MetJ D9E17_09540 ENOG4105FAV ABC, transporter D9E17_09545 ENOG4105FDK ABC transporter D9E17_09550 ENOG4105NXV High-affinity zinc uptake system protein D9E17_09555 ENOG4105DR5 peptidase D9E17_09560 ENOG4105NWR lipid A biosynthesis (Kdo)2-(Lauroyl)-lipid IVA acyltransferase D9E17_09565 ENOG4105CA9 Pyruvate kinase D9E17_09570 ENOG4106KNT transcriptional regulator D9E17_09575 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase D9E17_09580 ENOG4105C01 Dihydroxy-acid dehydratase D9E17_09585 ENOG4108UHU Aldolase D9E17_09595 ENOG4105X2V dna damage-inducible protein D9E17_09600 ENOG4105RSZ secreted protein D9E17_09605 ENOG4108Q2J Inner membrane protein YebE D9E17_09610 ENOG4105CUG Oligopeptidase b D9E17_09615 ENOG4105UMD exodeoxyribonuclease X D9E17_09620 ENOG4108YGA nitrilase cyanide hydratase and apolipoprotein n-acyltransferase D9E17_09625 ENOG4105MPK DNA polymerase III subunit theta D9E17_09630 ENOG4105FXM Copper resistance protein D9E17_09635 ENOG4108PNC copper resistance D9E17_09640 ENOG4105NKT exported protein D9E17_09645 ENOG4108R1E Serine threonine protein phosphatase 1 D9E17_09650 ENOG4105UVW uncharacterized protein yebW D9E17_09655 ENOG4105WT8 Protein of unknown function (DUF1480) D9E17_09665 ENOG4105DY2 Paraquat-inducible protein b D9E17_09670 ENOG4105H2K paraquat-inducible protein a D9E17_09675 ENOG4108ZGC gaf domain protein D9E17_09685 ENOG4105CN1 protease D9E17_09695 ENOG4105C0R drug resistance transporter emrb qaca subfamily D9E17_09700 ENOG4105J4Q Transcriptional regulator D9E17_09705 ENOG4105TIK D9E17_09715 ENOG4105Q3Y exported protein D9E17_09720 ENOG410610J Protein of unknown function (DUF2627) D9E17_09725 ENOG4105VEQ Cold shock protein D9E17_09730 ENOG4105DHI Methyltransferase D9E17_09745 ENOG4105F3R pts system mannose fructose sorbose family iid D9E17_09750 ENOG4105ETZ PTS System D9E17_09755 ENOG4108EQA pts system D9E17_09760 ENOG4105EE5 Membrane protein terC D9E17_09765 ENOG4107XTP (EAL) domain protein D9E17_09770 ENOG4105EJQ L-serine dehydratase D9E17_09780 ENOG4105CRQ synthase (Component I) D9E17_09790 ENOG4105V2F Uncharacterized protein yoac D9E17_09795 ENOG4105M4H endoribonuclease L-psp D9E17_09800 ENOG4105DVT helicase D9E17_09805 ENOG41072GX Peptidase M22 Glycoprotease D9E17_09810 ENOG4105Y4Z Outer Membrane Lipoprotein D9E17_09815 ENOG4105CEY Amp-dependent synthetase and ligase D9E17_09820 ENOG4105ZIE Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity) D9E17_09825 ENOG4105E3J oxidoreductase D9E17_09830 ENOG4105DVW rieske (2Fe-2S) D9E17_09835 ENOG4105C94 Transporter D9E17_09840 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) D9E17_09845 ENOG4105EJC lysr family transcriptional regulator D9E17_09855 ENOG4108YS1 cytoplasmic protein D9E17_09860 ENOG4105YP6 Domain of unknown function (DUF1869) D9E17_09865 ENOG4105Y3U Transglycosylase-associated protein D9E17_09875 ENOG4106G4W D9E17_09880 ENOG410620I Diguanylate cyclase D9E17_09885 ENOG4105UCG Domain of unknown function (DUF333) D9E17_09890 ENOG4105K78 MarR family Transcriptional regulator D9E17_09895 ENOG4105DJ2 Major Facilitator Superfamily D9E17_09900 ENOG4105R1U AraC Family Transcriptional Regulator D9E17_09915 ENOG4108KXH Ybak prolyl-tRNA synthetase associated D9E17_09920 ENOG4108KHP Diguanylate cyclase D9E17_09925 ENOG4106KTS Inner membrane protein yeaI D9E17_09935 ENOG4105CYN Serine protein kinase D9E17_09940 ENOG4105GNX MltA-interacting MipA family protein D9E17_09945 ENOG4105CV8 reductase D9E17_09950 ENOG4105DSB aldose 1-epimerase D9E17_09955 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase D9E17_09965 ENOG4105VUT cytoplasmic protein D9E17_09970 ENOG4105CPQ Dehydrogenase D9E17_09975 ENOG4107TE1 transport protein D9E17_09980 ENOG4105CPQ Dehydrogenase D9E17_09985 ENOG4105D2N Aldolase D9E17_09990 ENOG4107UH8 sugar kinase D9E17_09995 ENOG4105CPC Aldo Keto reductase D9E17_10000 ENOG4105E98 transcriptional regulator DeoR family D9E17_10020 ENOG4108RWI nicotinamidase D9E17_10025 ENOG4105HDK L-asparaginase D9E17_10030 ENOG4105D07 Signal peptide peptidase, SppA D9E17_10035 ENOG41069NU Nitroreductase D9E17_10045 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) D9E17_10050 ENOG4105F7F Chaperone D9E17_10055 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) D9E17_10060 ENOG4105D82 Glutamate dehydrogenase D9E17_10065 ENOG4105MTM Protein of unknown function (DUF1496) D9E17_10070 ENOG4105M6F mutator MutT protein D9E17_10075 ENOG4108T9J Cdp-alcohol phosphatidyltransferase D9E17_10080 ENOG4107RM6 sulfurtransferase D9E17_10085 ENOG4108VGW abc transporter atp-binding protein D9E17_10090 ENOG4105CXZ ABC transporter, permease D9E17_10095 ENOG4105VNH ABC transporter solute-binding protein D9E17_10100 ENOG4107ZN8 Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) D9E17_10105 ENOG4108N5C SNARE associated Golgi protein-related protein D9E17_10110 ENOG4108KCW iron-sulfur cluster binding D9E17_10115 ENOG4108RSN SNARE associated Golgi D9E17_10120 ENOG4105CGK Exodeoxyribonuclease III D9E17_10130 ENOG4105F4X arginine D9E17_10150 ENOG4108SPG Periplasmic Protein D9E17_10160 ENOG4105DKD Incises the DNA at the 3' side of a lesion during nucleotide excision repair. Incises the DNA farther away from the lesion than UvrC. Not able to incise the 5' site of a lesion. When a lesion remains because UvrC is not able to induce the 3' incision, Cho incises the DNA. Then UvrC makes the 5' incision. The combined action of Cho and UvrC broadens the substrate range of nucleotide excision repair (By similarity) D9E17_10170 ENOG4105KKI DNA-binding transcriptional activator OsmE D9E17_10175 ENOG4105VZJ PTS System D9E17_10180 ENOG4105CK1 PTS System D9E17_10185 ENOG4105VCP PTS System D9E17_10190 ENOG4105EZV Transcriptional regulator D9E17_10195 ENOG4105F8D glycoside hydrolase family 4 D9E17_10205 ENOG4105CH6 catalase D9E17_10220 ENOG4108ETY sodium dicarboxylate symporter D9E17_10225 ENOG4107K5X Membrane-bound metal-dependent hydrolase D9E17_10230 ENOG4107UW8 HAD-superfamily hydrolase subfamily IA variant 3 D9E17_10235 ENOG4107PN8 YfeABCD locus regulator D9E17_10240 ENOG4105FGM Fructosamine kinase D9E17_10245 ENOG4105P10 Uncharacterized protein ydiZ D9E17_10250 ENOG4105DE4 1-phosphofructokinase D9E17_10255 ENOG4108NE3 Salt-induced outer membrane protein D9E17_10280 ENOG41082NX 50s ribosomal protein l35 D9E17_10285 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) D9E17_10315 ENOG4108V06 Glutathione peroxidase D9E17_10325 ENOG4108QBX (LipO)protein D9E17_10330 ENOG4108TC0 Diguanylate phosphodiesterase D9E17_10340 ENOG4106EDX Hemin uptake protein D9E17_10345 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) D9E17_10355 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) D9E17_10360 ENOG4105CEY Amp-dependent synthetase and ligase D9E17_10365 ENOG41090P5 ferredoxin-like protein D9E17_10370 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase D9E17_10375 ENOG4105C10 Electron transfer flavoprotein D9E17_10380 ENOG4105CV7 Electron transfer flavoprotein D9E17_10385 ENOG4105W4W Transcriptional regulator D9E17_10390 ENOG4105C1G acyl-Coa dehydrogenase D9E17_10395 ENOG4107R0K CoA transferase having broad substrate specificity for short-chain acyl-CoA thioesters with the activity decreasing when the length of the carboxylic acid chain exceeds four carbons (By similarity) D9E17_10410 ENOG4105EMV Major Facilitator D9E17_10415 ENOG4105EMV Major Facilitator D9E17_10420 ENOG4105SUA Ydil protein D9E17_10430 ENOG4105IPI Membrane D9E17_10435 ENOG4105CQB FAD linked oxidase domain protein D9E17_10440 ENOG4105KA0 thioesterase Superfamily protein D9E17_10445 ENOG410671Z uncharacterized protein ydiH D9E17_10450 ENOG4108Z4V iron-sulfur cluster assembly D9E17_10455 ENOG4105DIW FeS assembly protein SUFB D9E17_10460 ENOG4105C3K feS assembly ATPase SufC D9E17_10465 ENOG4105JRK feS assembly protein SufD D9E17_10480 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein D9E17_10485 ENOG4105KMX major outer membrane lipoprotein D9E17_10490 ENOG4105CA9 Pyruvate kinase D9E17_10495 ENOG4105RFR Protein of unknown function (DUF2767) D9E17_10500 ENOG4108PU5 4fe-4S ferredoxin, iron-sulfur binding domain protein D9E17_10505 ENOG4105WE2 aldehyde ferredoxin oxidoreductase D9E17_10510 ENOG4105JVW D9E17_10515 ENOG4108393 oxidoreductase Fe-S subunit D9E17_10520 ENOG4108NWD Cytochrome D9E17_10525 ENOG4108Y7C Conserved Protein D9E17_10530 ENOG4108KTU conserved protein with FAD NAD(P)-binding domain D9E17_10535 ENOG4105N0V mono-oxygenase ydhR D9E17_10560 ENOG4108R6K riboflavin synthase, subunit alpha D9E17_10565 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase D9E17_10570 ENOG4105CZQ inner membrane transport protein YdhC D9E17_10575 ENOG4105F52 Transcriptional regulator D9E17_10590 ENOG4105F27 Major Facilitator D9E17_10595 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) D9E17_10600 ENOG4105K4H Nlp p60 protein D9E17_10605 ENOG4105M2J Glutaredoxin D9E17_10610 ENOG4107QRT dEAD DEAH box helicase D9E17_10620 ENOG4108UYE Lactoylglutathione lyase D9E17_10625 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase D9E17_10630 ENOG4108WUH Transcriptional regulator, TetR family D9E17_10635 ENOG4105XZD Fe-S protein D9E17_10640 ENOG4107RGM aldo keto reductase D9E17_10645 ENOG4108Z7T Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) D9E17_10650 ENOG4105DSW Fusaric acid resistance protein D9E17_10655 ENOG4105Y49 secretion protein, HlyD family D9E17_10670 ENOG4108XTF Outer Membrane Lipoprotein D9E17_10680 ENOG410642K Lysozyme inhibitor D9E17_10695 ENOG4107XGF functions in a salvage pathway. Uses pyridoxamine (By similarity) D9E17_10700 ENOG4108K3A Glutathione S-transferase D9E17_10705 ENOG4105DUX Transporter D9E17_10710 ENOG4105CSM endonuclease III D9E17_10720 ENOG4108UQQ Electron transport complex D9E17_10745 ENOG4105M9B inner membrane protein ydgK D9E17_10750 ENOG4105QZ5 OriC-binding nucleoid-associated protein D9E17_10755 ENOG4106C6R beta-lactam resistance protein D9E17_10760 ENOG4105D9R oxidoreductase D9E17_10770 ENOG4105C87 Aminotransferase class I and II D9E17_10775 ENOG4105CI1 PTS System D9E17_10780 ENOG4107P2S Transcriptional regulator D9E17_10785 ENOG4107ZQV short-chain dehydrogenase reductase D9E17_10790 ENOG4105XEA Tetr family transcriptional regulator D9E17_10795 ENOG4105CNT hydrolase family 2 D9E17_10800 ENOG4105CT4 transporter D9E17_10805 ENOG4108QNI outer membrane porin protein D9E17_10820 ENOG4106J39 exported protein D9E17_10825 ENOG4105EIP mannose-6-phosphate isomerase D9E17_10830 ENOG4107GFK fumarate D9E17_10835 ENOG4105C9Q fumarate hydratase class II D9E17_10845 ENOG4105JJR Histidine kinase D9E17_10850 ENOG4107EXC regulatoR D9E17_10855 ENOG4105RA2 Membrane D9E17_10860 ENOG410642E Short chain dehydrogenase D9E17_10865 ENOG4105D5Q Arginine ornithine antiporter D9E17_10870 ENOG4105C5D exported protein D9E17_10875 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) D9E17_10880 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) D9E17_10885 ENOG4105DSF transport protein D9E17_10905 ENOG4105CVW peptidase s1 and s6 chymotrypsin hap D9E17_10920 ENOG4105D94 Major Facilitator Superfamily D9E17_10925 ENOG4106NZI LysR family Transcriptional regulator D9E17_10930 ENOG4105DAG ROK family D9E17_10935 ENOG4105EWW Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) D9E17_10945 ENOG4108NEM leader-binding protein dmsD D9E17_10950 ENOG4107KGK dmso reductase anchor subunit D9E17_10955 ENOG4105QAX Iron-sulfur D9E17_10960 ENOG4105C3J Cysteine desulfurase D9E17_10965 ENOG4107QY8 reductase D9E17_10970 ENOG4105KBG Protein of unknown function (DUF1161) D9E17_10980 ENOG4108MK9 spermidine N(1)-acetyltransferase D9E17_10995 ENOG4105CXK mandelate racemase muconate lactonizing D9E17_11000 ENOG4105CPQ Dehydrogenase D9E17_11010 ENOG4107R08 Integrase D9E17_11025 ENOG4106G8A Qin prophage D9E17_11040 ENOG4105HGD Antitermination protein D9E17_11055 ENOG4105VEQ Cold shock protein D9E17_11060 ENOG4105QFS Lysis protein S homolog from lambdoid prophage D9E17_11075 ENOG4108YV9 Protein of unknown function (DUF2514) D9E17_11080 ENOG4105VEQ Cold shock protein D9E17_11090 ENOG4106IAW D9E17_11095 ENOG4106H71 Overexpression increases levels of unsaturated fatty acids and suppresses both the temperature-sensitive fabA6 mutation and cold-sensitive secG null mutation D9E17_11110 ENOG4106YSC D9E17_11115 ENOG4105FKG DNA packaging protein D9E17_11130 ENOG4105UZW Tail fiber assembly protein D9E17_11135 ENOG4105MN3 Resolvase D9E17_11140 ENOG4105W3V DNA-binding, transcriptional regulator D9E17_11155 ENOG4105DEI Mannitol dehydrogenase D9E17_11160 ENOG41061EV selenium-binding protein YdfZ D9E17_11165 ENOG4107XBN GntR Family Transcriptional Regulator D9E17_11170 ENOG4105EMU Dehydrogenase D9E17_11175 ENOG4105DGW oligopeptidase A D9E17_11180 ENOG4108WTK competence damage-inducible protein D9E17_11185 ENOG4108YDI single-species biofilm formation on inanimate substrate D9E17_11190 ENOG4105FSR swimming returnes to normal when residues 206-207 are both mutated to Ala. Overexpression also leads to a reduction in flagellar abundance and a 20-fold increase in c-di- GMP levels in vivo. Required for aminoglycoside-mediated induction of biofilm formation, it also plays a lesser role in biofilm production in response to other classes of translation inhibitors. The c-di-GMP produced by this enzyme up-regulates poly-GlcNAc production as well as the biofilm synthesis protein PgaD, although c-di-GMP is probably not the main inducing principle. Cyclic-di- GMP is a second messenger which controls cell surface-associated traits in bacteria D9E17_11200 ENOG4105E5W Transporter D9E17_11205 ENOG4108594 Permease of the drug metabolite transporter D9E17_11210 ENOG4106DNR multiple antibiotic resistance protein D9E17_11215 ENOG4108XW0 May be a transcriptional activator of genes involved in the multiple antibiotic resistance (Mar) phenotype. It can also activate genes such as sodA, zwf and micF D9E17_11220 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes D9E17_11240 ENOG4105EGI Transcriptional regulator D9E17_11245 ENOG4105C26 Dehydrogenase D9E17_11250 ENOG4105CSV Glutaminase D9E17_11255 ENOG4105M0C cytoplasmic protein D9E17_11260 ENOG4105BZU Histidine kinase D9E17_11270 ENOG4105FFC UPF0187 protein D9E17_11280 ENOG4105K34 Involved in the degradation of phospho-AI-2, thereby terminating induction of the lsr operon and closing the AI-2 signaling cycle. Catalyzes the cleavage of phosphorylated 4,5- dihydroxy-2,3-pentanedione (P-DPD) to 2-phosphoglycolic acid (PG) and another three-carbon compound D9E17_11290 ENOG4105D4B ABC, transporter D9E17_11295 ENOG4105F5R ABC transporter D9E17_11305 ENOG4105C2J ABC transporter D9E17_11310 ENOG4105DKT Transcriptional regulator D9E17_11325 ENOG41061P8 Persistence to inhibition of murein or DNA biosynthesis regulatory protein D9E17_11330 ENOG4105CAF HipA N-terminal domain protein D9E17_11345 ENOG4108WDE Fimbrial protein D9E17_11350 ENOG4106318 fimbrial-like protein YdeR D9E17_11355 ENOG4106PIH fimbrial-like protein ydeQ D9E17_11360 ENOG4107QKC Oxidoreductase alpha (molybdopterin) subunit D9E17_11375 ENOG4105ENH Sulfatase D9E17_11380 ENOG4105C4X radical SAM domain protein D9E17_11390 ENOG4105CQ0 ABC transporter D9E17_11395 ENOG4105PE1 Receptor D9E17_11400 ENOG4107RAN Peptidase, M16 D9E17_11405 ENOG4105CVK Glutamate decarboxylase D9E17_11410 ENOG4105E5D amino acid D9E17_11415 ENOG4105F32 YngK protein D9E17_11420 ENOG4105BZU Histidine kinase D9E17_11425 ENOG4105BZU Histidine kinase D9E17_11430 ENOG4108UQS dipeptidase D9E17_11435 ENOG4105DEF Extracellular solute-binding protein, family 5 D9E17_11440 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component D9E17_11445 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component D9E17_11450 ENOG4105C3U ABC transporter D9E17_11455 ENOG4107H6U ABC transporter D9E17_11460 ENOG4108Z9K Osmotically inducible protein D9E17_11465 ENOG4105TPS biofilm-dependent modulation protein D9E17_11470 ENOG4107AV5 Although this protein associates with the 30S subunit of the ribosome it is not considered to be a bona fide ribosomal protein D9E17_11480 ENOG4105DQ4 alcohol dehydrogenase D9E17_11485 ENOG41084S7 Plasmid maintenance system antidote protein D9E17_11490 ENOG4108MG3 formate dehydrogenase D9E17_11495 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein D9E17_11505 ENOG4105RPH Inner membrane protein YddG D9E17_11515 ENOG4107QND Nitrite extrusion protein D9E17_11520 ENOG4105CRU nitrate reductase, alpha subunit D9E17_11525 ENOG4108IUE nitrate reductase beta subunit D9E17_11530 ENOG4108NZN Respiratory nitrate reductase 2 delta chain D9E17_11535 ENOG4105D0D Nitrate reductase 2, gamma subunit D9E17_11540 ENOG4105JAB phenazine biosynthesis protein, phzf family D9E17_11545 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase D9E17_11550 ENOG4108MEJ flavin reductase domain protein D9E17_11585 ENOG4105CS6 Rhs element vgr protein D9E17_11595 ENOG4108N27 Glutathione S-transferase D9E17_11600 ENOG4105C85 amino acid D9E17_11605 ENOG4108NS2 receptor D9E17_11610 ENOG4105CHB tonB-dependent Receptor D9E17_11615 ENOG4108WYP Transcriptional regulator D9E17_11620 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein D9E17_11625 ENOG4108Z7F N-acetyltransferase D9E17_11630 ENOG4108T9Y Inner membrane protein ydcZ D9E17_11635 ENOG4105R71 cytoplasmic protein D9E17_11640 ENOG410654E Membrane D9E17_11655 ENOG4105NRK Binding-protein-dependent transport systems, inner membrane component D9E17_11660 ENOG4105D81 ABC transporter, permease D9E17_11665 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) D9E17_11670 ENOG4107TYH extracellular solute-binding protein family 1 D9E17_11675 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family D9E17_11680 ENOG4105PF0 Antitoxin component of a toxin-antitoxin (TA) module. Functions as an mRNA interferase antitoxin D9E17_11690 ENOG4105RR0 Protein of unknown function (DUF2554) D9E17_11700 ENOG4108JCI Transcriptional regulator D9E17_11705 ENOG4105DKK Benzoate D9E17_11710 ENOG4105D7V transposase D9E17_11720 ENOG4108KKZ (LipO)protein D9E17_11725 ENOG41088CC tellurite resistance protein tehB D9E17_11730 ENOG4108NKP c4-dicarboxylate transporter malic acid transport protein D9E17_11735 ENOG4107WE3 acetyltransferase YdcK D9E17_11740 ENOG4108Z9I -acetyltransferase D9E17_11745 ENOG4105Z2P Protein of unknown function (DUF465) D9E17_11755 ENOG4105E32 cytoplasmic protein D9E17_11760 ENOG4105DDW LysR family Transcriptional regulator D9E17_11765 ENOG4105C8Q Methyl-accepting chemotaxis D9E17_11775 ENOG4107NK6 Hok/gef family D9E17_11780 ENOG4105UPP uncharacterized protein ydcA D9E17_11785 ENOG4105CPW cytochrome b561 D9E17_11790 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase D9E17_11795 ENOG4105C26 Dehydrogenase D9E17_11800 ENOG4107DB1 DUF218 domain D9E17_11805 ENOG4105CQ7 ATP-dependent helicase D9E17_11815 ENOG41077RS Phosphatase D9E17_11820 ENOG4105E8V Alpha Beta Hydrolase Fold protein D9E17_11825 ENOG4108HPI phosphatidate Cytidylyltransferase D9E17_11830 ENOG4108UMZ Cdp-alcohol phosphatidyltransferase D9E17_11845 ENOG4107EF2 surface-exposed virulence protein D9E17_11860 ENOG4108Z0R Transferase D9E17_11865 ENOG4105V9J phenylacetic acid degradation operon negative regulatory protein D9E17_11870 ENOG4105DZS Phenylacetate-CoA ligase D9E17_11875 ENOG4105CHU acetyl-coa acetyltransferase D9E17_11880 ENOG4108ZJI phenylacetic acid degradation protein D9E17_11885 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase D9E17_11890 ENOG4108UKI Enoyl-CoA hydratase D9E17_11895 ENOG4105E39 Enoyl-CoA hydratase D9E17_11900 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) D9E17_11905 ENOG4108ZA2 phenylacetate-CoA oxygenase PaaJ subunit D9E17_11910 ENOG4105D9S phenylacetate-CoA oxygenase PaaI subunit D9E17_11915 ENOG4105N76 Phenylacetate-CoA oxygenase, subunit D9E17_11920 ENOG4105CRS phenylacetate-CoA oxygenase PaaG subunit D9E17_11925 ENOG4105DXM phenylacetic acid degradation protein D9E17_11930 ENOG4105F11 amine oxidase D9E17_11935 ENOG4105C26 Dehydrogenase D9E17_11940 ENOG4108WFR AraC Family Transcriptional Regulator D9E17_11945 ENOG4105WXT Conserved Protein D9E17_11950 ENOG410689M (LipO)protein D9E17_11955 ENOG4107H52 Dicarboxylate transport D9E17_11960 ENOG4105C5I Dehydrogenase D9E17_11965 ENOG41090X5 Heat shock protein hslJ D9E17_11975 ENOG4105D95 Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity) D9E17_11980 ENOG4105FCK Membrane D9E17_11985 ENOG4108RW8 Universal stress protein F D9E17_11995 ENOG4105C1J atp-dependent rna helicase D9E17_12005 ENOG4105BZU Histidine kinase D9E17_12010 ENOG4108DG9 Smr protein MutS2 D9E17_12015 ENOG4106KR7 LysR family Transcriptional regulator D9E17_12020 ENOG4105CH2 amidohydrolase D9E17_12025 ENOG4107RT5 aminobenzoyl-glutamate utilization protein B D9E17_12030 ENOG4105CFC Transporter D9E17_12035 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) D9E17_12040 ENOG4105DS0 Transcriptional regulator, Crp Fnr family D9E17_12045 ENOG4105Q9Y Universal stress protein D9E17_12050 ENOG4105S5I Membrane D9E17_12055 ENOG4105D64 Mechanosensitive ion channel D9E17_12060 ENOG4107QSI ABC, transporter D9E17_12065 ENOG4105EQ2 LysR family Transcriptional regulator D9E17_12070 ENOG4105ENX hydrolase D9E17_12085 ENOG4105KXI murein peptide amidase A D9E17_12090 ENOG4107S8C mandelate racemase muconate lactonizing D9E17_12095 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) D9E17_12100 ENOG4108JU8 Transcriptional regulator D9E17_12110 ENOG4105CM6 amino acid regulated cytosolic protein D9E17_12115 ENOG4105FKQ transcriptional regulator D9E17_12120 ENOG4107EFV Outer membrane protein G D9E17_12125 ENOG4108IJ9 (ABC) transporter D9E17_12130 ENOG4107URF beta-phospho-glucomutase D9E17_12135 ENOG4105C71 hydrolase family 65, central catalytic D9E17_12140 ENOG4105CK5 oxidoreductase D9E17_12150 ENOG4107RRD Dehydrogenase D9E17_12155 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component D9E17_12160 ENOG4105HS6 binding-protein-dependent transport systems inner membrane Component D9E17_12165 ENOG4105WEM extracellular solute-binding protein D9E17_12170 ENOG4107QW3 Sucrose phosphorylase D9E17_12175 ENOG4105K8Z Phage shock protein D9E17_12180 ENOG4105NNG Peripheral inner membrane phage-shock protein D9E17_12185 ENOG4105FM1 phage shock protein C D9E17_12190 ENOG4105YYT phage shock protein B D9E17_12195 ENOG41087YS Phage shock protein A D9E17_12200 ENOG4105E51 psp operon transcriptional activator D9E17_12205 ENOG4108JPW Aminotransferase D9E17_12210 ENOG4105CJP fad dependent oxidoreductase D9E17_12215 ENOG4105C26 Dehydrogenase D9E17_12220 ENOG4107VRI Transcriptional regulator D9E17_12225 ENOG4108Z86 Glutamine amidotransferase D9E17_12230 ENOG4105CFQ glutamine synthetase D9E17_12240 ENOG4105CUB amino acid D9E17_12245 ENOG4105N0E Protein of unknown function (DUF2543) D9E17_12250 ENOG4108HIY periplasmic D9E17_12255 ENOG4108I5W peptide transport system, permease protein D9E17_12260 ENOG4108EU3 peptide transport system, permease D9E17_12265 ENOG4108JQ3 Peptide ABC transporter ATP-binding protein D9E17_12270 ENOG4108JQ2 peptide transport system atp-binding protein D9E17_12275 ENOG4105WDY DNA (cytosine-5-)-methyltransferase D9E17_12280 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH D9E17_12285 ENOG4105Q4T oxidoreductase D9E17_12300 ENOG4105BZU Histidine kinase D9E17_12310 ENOG4105N2W Transcriptional regulator D9E17_12315 ENOG41061RM osmotically inducible lipoprotein D9E17_12320 ENOG4108ZJT translation initiation factor, Sui1 D9E17_12330 ENOG4105CFV Tetratricopeptide repeat protein D9E17_12335 ENOG4105Q4A inner membrane protein yciS D9E17_12340 ENOG4105EYK Phosphatidylglycerophosphatase B D9E17_12350 ENOG4107QM5 aconitate hydratase D9E17_12375 ENOG4107R11 Transcriptional regulator D9E17_12380 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) D9E17_12385 ENOG4105RKX Protein of unknown function (DUF2498) D9E17_12390 ENOG4105ERU peptidase D9E17_12395 ENOG4105UBK short-chain dehydrogenase reductase D9E17_12400 ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase D9E17_12405 ENOG4105FE9 pseudouridine synthase D9E17_12415 ENOG4107RTD sua5 ycio yrdc ywlc family protein D9E17_12420 ENOG4105DB7 PHP domain protein D9E17_12430 ENOG4105CRQ synthase (Component I) D9E17_12435 ENOG4108EFP Anthranilate synthase component II D9E17_12440 ENOG4105DK0 Indole-3-glycerol phosphate synthase D9E17_12460 ENOG4108Z9Z response to DNA damage stimulus D9E17_12465 ENOG4108N8X transition metal ion binding D9E17_12470 ENOG4105EIF outer membrane protein W D9E17_12490 ENOG4105NAU thioesterase Superfamily protein D9E17_12495 ENOG410822N TonB family D9E17_12500 ENOG4105K9H YciI-like protein D9E17_12505 ENOG4107SVH Potassium channel protein D9E17_12525 ENOG4108JQ7 (ABC) transporter D9E17_12530 ENOG4105C3U ABC transporter D9E17_12535 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component D9E17_12545 ENOG4108J59 Extracellular solute-binding protein, family 5 D9E17_12550 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein D9E17_12555 ENOG4108EKI Dehydrogenase D9E17_12560 ENOG4107104 thymidine kinase D9E17_12565 ENOG4108SAU DNA-binding protein H-ns D9E17_12570 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase D9E17_12575 ENOG4105I93 response regulator D9E17_12580 ENOG4105D78 K07001 NTE family protein D9E17_12590 ENOG4105CIY formyltetrahydrofolate deformylase D9E17_12625 ENOG41076YT nitrate reductase, gamma subunit D9E17_12630 ENOG4105R3A Nitrate reductase D9E17_12635 ENOG4108IUE nitrate reductase beta subunit D9E17_12640 ENOG4105CRU nitrate reductase, alpha subunit D9E17_12645 ENOG4105DQQ Major facilitator superfamily MFS_1 D9E17_12650 ENOG4105BZU Histidine kinase D9E17_12655 ENOG4105WH1 Two component transcriptional regulator luxr family D9E17_12660 ENOG4105ID0 Putative invasin D9E17_12665 ENOG41090EX DsrE family D9E17_12670 ENOG4108NH8 Cation transport protein D9E17_12675 ENOG4105WS7 Cation transport regulator D9E17_12680 ENOG4105EWV Sodium calcium exchanger membrane region D9E17_12725 ENOG41063JG Transcriptional regulator D9E17_12730 ENOG4108YY7 Invasion gene expression up-regulator SirB D9E17_12735 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) D9E17_12760 ENOG4105C5T Phosphoribosyl pyrophosphate synthase D9E17_12765 ENOG4105CHH sulfate transporter D9E17_12770 ENOG4105MGX transcription activated by CRP (cyclic AMP receptor protein), a global transcription factor involved in regulation of metabolism in enteric bacteria D9E17_12780 ENOG4105C3G gtp-binding protein D9E17_12785 ENOG4105I1J Autotransporter D9E17_12790 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family D9E17_12795 ENOG4105CMT Dihydroxyacetone kinase D9E17_12800 ENOG4108UTZ Dihydroxyacetone kinase D9E17_12805 ENOG4105VDH Dihydroxyacetone kinase D9E17_12825 ENOG4108T7K Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Increasing levels of c-di-GMP lead to decreased motility (By similarity) D9E17_12835 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A D9E17_12845 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) D9E17_12855 ENOG4105ED1 spovr family D9E17_12870 ENOG410635M Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein (By similarity) D9E17_12875 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) D9E17_12880 ENOG4105KT5 UmuD protein D9E17_12885 ENOG4106PXS Toxin, which has some hemolytic activity towards mammalian cells. Acts by forming a pore-like structure upon contact with mammalian cells D9E17_12895 ENOG4105FBJ fumarylacetoacetate (faa) hydrolase D9E17_12905 ENOG41066UD Inhibits activity of g-type lysozyme, which confers increased lysozyme tolerance to the bacterium D9E17_12910 ENOG4105S66 prophage protein D9E17_12920 ENOG4107QMS site-determining protein D9E17_12955 ENOG410658X D9E17_12970 ENOG4105BZU Histidine kinase D9E17_12975 ENOG410738I uncharacterized protein ymgC D9E17_12985 ENOG41077SS Probably a connector protein for RcsB C regulation of biofilm formation, providing additional signal input into the two- component signaling pathway. May serve to stimulate biofilm maturation, probably via the Rcs phosphorelay. Mild overexpression at 16 degrees Celsius increases the production of colanic acid, an exopolysaccharide and matrix component, and reduces adhesive curli fimbriae expression. Both of these effects require RcsB D9E17_12990 ENOG4105WKE Probably a connector protein for RcsB C regulation of biofilm formation, providing additional signal input into the two- component signaling pathway. Partially antagonizes the activities of YmgA and AriR, proteins that, via the Rcs phosphorelay, promote the synthesis of colanic acid, an exopolysaccharide and matrix component D9E17_12995 ENOG4105BZU Histidine kinase D9E17_13000 ENOG4108XDN Transcriptional regulator D9E17_13005 ENOG41064WM Uncharacterized protein YcgX D9E17_13020 ENOG4108HMX isocitrate dehydrogenase (NADP) D9E17_13025 ENOG4108R99 pseudouridine synthase D9E17_13045 ENOG4107QTF adenylosuccinate lyase D9E17_13050 ENOG4105XJC Two component transcriptional regulator (Winged helix family D9E17_13055 ENOG4105IFJ Histidine kinase D9E17_13060 ENOG4105EZE Cupin 4 family protein D9E17_13075 ENOG4105F38 ABC transporter, permease D9E17_13080 ENOG4105D38 putrescine abc transporter D9E17_13085 ENOG4107RUE extracellular solute-binding protein family 1 D9E17_13100 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) D9E17_13110 ENOG4105D60 lipoprotein releasing system transmembrane protein D9E17_13115 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) D9E17_13120 ENOG4105D60 lipoprotein releasing system transmembrane protein D9E17_13130 ENOG4108JA2 transcriptioN-repair coupling factor D9E17_13135 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein D9E17_13140 ENOG4105RC8 Reduces the permeability of the outer membrane to copper. Seems to be involved in the regulation of biofilm formation. May decrease biofilm formation by repressing cell-cell interaction and cell surface interaction D9E17_13145 ENOG4108IND Tetr family transcriptional regulator D9E17_13150 ENOG4107MBR 17 kDa surface antigen D9E17_13155 ENOG4105CEP NADH dehydrogenase D9E17_13175 ENOG4108WEF Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b) (By similarity) D9E17_13180 ENOG41090DQ Lipoprotein D9E17_13185 ENOG4105K59 histidine triad (HIT) protein D9E17_13190 ENOG4105CNM Receptor D9E17_13195 ENOG4105CI1 PTS System D9E17_13200 ENOG4105F8V Hydrolase, tatD family D9E17_13205 ENOG4107QRG dna polymerase iii D9E17_13215 ENOG4105HHA aminodeoxychorismate lyase D9E17_13220 ENOG4105YAZ 4-amino-4-deoxychorismate lyase D9E17_13225 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) D9E17_13230 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) D9E17_13235 ENOG4105CHR reductase D9E17_13240 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase D9E17_13260 ENOG4105FCQ metal-binding, possibly nucleic acid-binding protein D9E17_13265 ENOG4108UHJ MAF-like protein D9E17_13270 ENOG4105EI2 Pseudouridine synthase D9E17_13275 ENOG4107QQB Ribonuclease E D9E17_13280 ENOG4105DTJ flagellar hook-associated protein D9E17_13285 ENOG4105E1Q flagellar hook-associated protein D9E17_13290 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj D9E17_13305 ENOG4105CGA flagellar basal-body rod protein FlgG D9E17_13310 ENOG4108KPB Flagellar basal-body rod protein FlgF D9E17_13315 ENOG4105BZE flagellar hook protein, FlgE D9E17_13320 ENOG4105W00 Flagellar hook capping protein D9E17_13325 ENOG4108ZC9 flagellar basal-body rod protein flgc D9E17_13330 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) D9E17_13335 ENOG4105CKS Flagella basal body P-ring formation protein flgA D9E17_13340 ENOG4105M9M anti-sigma28 factor FlgM D9E17_13345 ENOG4105QVD Flagella synthesis protein FlgN D9E17_13350 ENOG4105CJR Integral membrane protein (MviN D9E17_13355 ENOG4105EP9 oxidoreductase D9E17_13365 ENOG4105D9U N-acetyltransferase D9E17_13375 ENOG4105E9S glutaredoxin 2 D9E17_13380 ENOG4105F3T (LipO)protein D9E17_13390 ENOG4105MEA DNA damage-inducible protein i D9E17_13395 ENOG4105PVA Biofilm formation regulatory protein BssS D9E17_13405 ENOG4106974 biofilm formation D9E17_13410 ENOG4105DS1 cytochrome b561 D9E17_13415 ENOG4108YYC ycei family D9E17_13425 ENOG4105D1S lipid A biosynthesis D9E17_13435 ENOG4108W47 Acidic protein msyB D9E17_13440 ENOG4105NAC (LipO)protein D9E17_13445 ENOG4105C3A Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs) (By similarity) D9E17_13460 ENOG4107RZC phospholipase d D9E17_13465 ENOG4108UVJ appr-1-p processing domain protein D9E17_13475 ENOG4105RK8 Plays a role in the extracellular assembly of CsgA into thin aggregative fimbriae (Tafi) fibers. Assembly may also require CsgE. Tafi are thought to be assembled via an extracellular nucleation-precipitation (ENP) pathway, and possibly also via an intracellular non-CsgC-dependent pathway (By similarity) D9E17_13480 ENOG4105G76 Curli are coiled surface structures that assemble preferentially at growth temperatures below 37 degrees Celsius. Curli can bind to fibronectin D9E17_13485 ENOG4108U0V Curli are coiled surface structures that assemble preferentially at growth temperatures below 37 degrees Celsius. Curli can bind to fibronectin. The minor subunit is the nucleation component of curlin monomers D9E17_13495 ENOG41086KC Transcriptional regulator D9E17_13500 ENOG4108XDW curli assembly protein CsgE D9E17_13505 ENOG4108WYR Curli production assembly transport component, CsgF D9E17_13510 ENOG4105P8Q Curli production assembly transport component CsgG D9E17_13515 ENOG4108UQ5 membrane protein YcdZ D9E17_13520 ENOG4107XHZ cytoplasmic chaperone TorD family protein D9E17_13555 ENOG4108T85 Membrane D9E17_13570 ENOG4105BZU Histidine kinase D9E17_13575 ENOG4108TUY outer membrane protein PgaA D9E17_13580 ENOG4107BJW polysaccharide deacetylase D9E17_13585 ENOG4105CND Glycosyl transferase, family 2 D9E17_13590 ENOG4106FQ9 Biofilm PGA synthesis protein PgaD D9E17_13595 ENOG4105D5M phosphate starvation-inducible protein D9E17_13600 ENOG4105DBE peroxidase D9E17_13605 ENOG410650H (LipO)protein D9E17_13610 ENOG4105EKT )-iron permease D9E17_13615 ENOG4105CK7 Sodium proline symporter D9E17_13625 ENOG4105C26 Dehydrogenase D9E17_13630 ENOG4108R86 Transcriptional regulator D9E17_13645 ENOG4106XMA In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2 (By similarity) D9E17_13655 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) D9E17_13670 ENOG4105C2W permease D9E17_13675 ENOG4105XF5 Escherichia coli IMT2125 genomic chromosome, IMT2125 D9E17_13685 ENOG4105XH3 D9E17_13690 ENOG4105D6F Phosphatase D9E17_13710 ENOG4108SBI Involved in the biogenesis of TorA. Acts on TorA before the insertion of the molybdenum cofactor and, as a result, probably favors a conformation of the apoenzyme that is competent for acquiring the cofactor (By similarity) D9E17_13715 ENOG4107QY8 reductase D9E17_13720 ENOG4105CUW cytochrome C-TYPE protein D9E17_13725 ENOG4106WF9 DNA-binding transcriptional regulator TorR D9E17_13730 ENOG4108SV3 Tmao reductase system periplasmic protein tort D9E17_13735 ENOG4105BZU Histidine kinase D9E17_13740 ENOG4105HEE Binding Domain protein D9E17_13745 ENOG4106H71 Overexpression increases levels of unsaturated fatty acids and suppresses both the temperature-sensitive fabA6 mutation and cold-sensitive secG null mutation D9E17_13760 ENOG4105VEQ Cold shock protein D9E17_13765 ENOG41060EU Cold shock-like protein D9E17_13780 ENOG4108Y9B (LipO)protein D9E17_13785 ENOG4108W78 Pfam:DUF1017 D9E17_13790 ENOG4105E3R (LipO)protein D9E17_13795 ENOG4105DAY polysaccharide export protein D9E17_13800 ENOG4107ZF2 Phosphatase D9E17_13805 ENOG4108F2G Chain length determinant protein D9E17_13810 ENOG4105D6F Phosphatase D9E17_13820 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii D9E17_13825 ENOG4105C4M (Ubiquinol oxidase) subunit I D9E17_13830 ENOG4105MVP hydrogenase-1 operon protein HyaF D9E17_13835 ENOG4108VXY Hydrogenase-1 operon protein HyaE D9E17_13840 ENOG4108USZ hydrogenase D9E17_13845 ENOG4105X7T Ni Fe-hydrogenase, b-type cytochrome subunit D9E17_13850 ENOG4105DPX Hydrogenase, large subunit D9E17_13855 ENOG4105E3S small subunit D9E17_13865 ENOG4108MN8 Membrane D9E17_13870 ENOG4108Z0T Part of a sulfur-relay system (By similarity) D9E17_13875 ENOG4105VSY K01512 acylphosphatase EC 3.6.1.7 D9E17_13890 ENOG4105K4P CoA-binding domain protein D9E17_13905 ENOG41088T4 Helicase IV D9E17_13910 ENOG410901E Membrane D9E17_13915 ENOG4105EM2 membrane D9E17_13920 ENOG4108RZ1 DNA transformation protein D9E17_13930 ENOG4105UYK outer membrane protein a D9E17_13940 ENOG4105DAN ATP-dependent protease D9E17_13950 ENOG4105WFT During stationary phase, converts 70S ribosomes to an inactive dimeric form (100S ribosomes) (By similarity) D9E17_13955 ENOG4108Q2G (LipO)protein D9E17_13960 ENOG4105DY2 Paraquat-inducible protein b D9E17_13965 ENOG4105F1S paraquat-inducible protein a D9E17_13970 ENOG4105C5H ABC transporter D9E17_13975 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) D9E17_13980 ENOG4105QVC MOSC domain-containing protein D9E17_13985 ENOG4108T7E Contributes to the efficiency of the cell division process by stabilizing the polymeric form of the cell division protein FtsZ. Acts by promoting interactions between FtsZ protofilaments and suppressing the GTPase activity of FtsZ (By similarity) D9E17_13995 ENOG4106PH7 chaperone D9E17_14000 ENOG4105MX3 Fimbrial D9E17_14005 ENOG4105Q7J Fimbrial D9E17_14010 ENOG4108MDY Fimbrial D9E17_14015 ENOG4105CW0 outer membrane usher protein D9E17_14020 ENOG4106JJN Part of the elfADCG-ycbUVF fimbrial operon, which promotes adhesion of bacteria to different abiotic surfaces. Could be required for the biogenesis of the ElfA fimbriae D9E17_14025 ENOG41071VI Part of the elfADCG-ycbUVF fimbrial operon, which promotes adhesion of bacteria to different abiotic surfaces. ElfA is the major fimbrial subunit produced by this operon D9E17_14030 ENOG4108UZX fmn reductase D9E17_14035 ENOG4105GVF (ABC) transporter D9E17_14045 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component D9E17_14050 ENOG4105E2Y ABC, transporter D9E17_14055 ENOG4105CD8 aminopeptidase N D9E17_14070 ENOG4105FCK Membrane D9E17_14075 ENOG4105CGF Aromatic amino acid aminotransferase D9E17_14080 ENOG4105C5X domain protein D9E17_14085 ENOG4105EAQ (twin-arginine translocation) pathway signal D9E17_14090 ENOG4105DIT ErfK YbiS YcfS YnhG family protein D9E17_14095 ENOG4105DUC Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division (By similarity) D9E17_14100 ENOG4105DAH Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF (By similarity) D9E17_14110 ENOG4106371 Methyltransferase D9E17_14115 ENOG4107S90 membrAne D9E17_14120 ENOG4107VR7 transferase activity, transferring phosphorus-containing groups D9E17_14135 ENOG4105T0Z Conserved Protein D9E17_14145 ENOG4105BZ1 (ABC) transporter D9E17_14150 ENOG4108EQH DNA internalization-related competence protein ComEC Rec2 D9E17_14160 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) D9E17_14170 ENOG4108K0D peptidase, M48 D9E17_14185 ENOG4107VMU Membrane D9E17_14190 ENOG4105DDY UPF0142 protein ycaO D9E17_14195 ENOG4105TMB Formate nitrite transporter D9E17_14200 ENOG4105C6N Formate acetyltransferase D9E17_14205 ENOG4105F1A Pyruvate formate-lyase D9E17_14210 ENOG4108X0B nad(p)h dehydrogenase (quinone) D9E17_14215 ENOG410642W LysR family Transcriptional regulator D9E17_14220 ENOG4105E5D amino acid D9E17_14230 ENOG4105CHJ isochorismatase hydrolase D9E17_14235 ENOG4107KGK dmso reductase anchor subunit D9E17_14240 ENOG4105QAX Iron-sulfur D9E17_14245 ENOG4107QY8 reductase D9E17_14255 ENOG4105D1H recombination factor protein RarA D9E17_14265 ENOG4105CNU cell division protein FtsK D9E17_14270 ENOG4105EW9 transcriptional regulator AsnC family D9E17_14275 ENOG4105C3M thioredoxin reductase D9E17_14280 ENOG4108JJ9 ABC, transporter D9E17_14285 ENOG4108JJ8 (ABC) transporter D9E17_14295 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) D9E17_14310 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit D9E17_14320 ENOG4105VEQ Cold shock protein D9E17_14325 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) D9E17_14330 ENOG4105DJY efflux transporter, rnd family, mfp subunit D9E17_14335 ENOG4108MJ5 VirK protein D9E17_14340 ENOG4105CPB ATP-dependent endonuclease of the OLD family D9E17_14355 ENOG4105DWU Membrane D9E17_14365 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) D9E17_14370 ENOG4105C7K acetolactate synthase D9E17_14375 ENOG4105C5W Aldolase D9E17_14380 ENOG4105CGD Nad-dependent epimerase dehydratase D9E17_14385 ENOG4107VBM 3-beta hydroxysteroid dehydrogenase isomerase D9E17_14390 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase D9E17_14400 ENOG41064MM (LipO)protein D9E17_14405 ENOG4105E5Z arginine transporter ATP-binding subunit D9E17_14410 ENOG4106PMH Extracellular solute-binding protein family 3 D9E17_14415 ENOG4105GBT ABC transporter D9E17_14420 ENOG4105DMR ABC, transporter D9E17_14425 ENOG4106TNF Periplasmic binding protein D9E17_14435 ENOG4105RBQ inner membrane protein ybjO D9E17_14440 ENOG4105D38 putrescine abc transporter D9E17_14445 ENOG4105F38 ABC transporter, permease D9E17_14450 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) D9E17_14455 ENOG4107RUE extracellular solute-binding protein family 1 D9E17_14460 ENOG4108RMJ sensory transduction regulator D9E17_14470 ENOG4108DBC nitroreductase D9E17_14475 ENOG4105X20 member of the soxRS regulon which mediates in part the increased levels of superoxide in response to oxidative stress D9E17_14480 ENOG41090BQ Glutaredoxin D9E17_14485 ENOG4105GWF inner membrane protein YbjM D9E17_14495 ENOG4105ZTC transcriptional activator, Ogr delta D9E17_14500 ENOG4105DFE Dna adenine methylase D9E17_14505 ENOG4105KSC Transcriptional regulator, TraR DksA family D9E17_14530 ENOG4105MEH D9E17_14540 ENOG4105UPP uncharacterized protein ydcA D9E17_14545 ENOG4108IYT Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) D9E17_14555 ENOG4108RFG Tetr family transcriptional regulator D9E17_14560 ENOG4106UW1 Major Facilitator superfamily D9E17_14565 ENOG4108HCJ Hydrolase D9E17_14575 ENOG4107QF7 multi-drug D9E17_14580 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase D9E17_14585 ENOG4107FB0 transcriptional regulator DeoR family D9E17_14590 ENOG4105DZ1 carboxypeptidase D9E17_14595 ENOG4108TGY Glutathione S-transferase D9E17_14605 ENOG4105UFT Represses biofilm formation in M9C glu and LB glu media but not in M9C and LB media. Seems to act as a global regulator of several genes involved in catabolite repression and stress response and regulation of the uptake and export of signaling pathways. Could be involved the regulation of indole as well as uptake and export of AI-2 through a cAMP-dependent pathway D9E17_14615 ENOG41064RH membrane protein YliF D9E17_14620 ENOG4105BZU Histidine kinase D9E17_14625 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component D9E17_14635 ENOG4105DEF Extracellular solute-binding protein, family 5 D9E17_14645 ENOG4105D44 asparaginase D9E17_14650 ENOG4105CVM Molybdenum cofactor synthesis domain protein D9E17_14655 ENOG4105D06 uba thif-type nad fad binding protein D9E17_14660 ENOG4107T9Z Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) D9E17_14665 ENOG4105F1A Pyruvate formate-lyase D9E17_14670 ENOG4105C6N Formate acetyltransferase D9E17_14675 ENOG4108HCJ Hydrolase D9E17_14680 ENOG41072TH Protein of unknown function (DUF1479) D9E17_14685 ENOG4105C5H ABC transporter D9E17_14690 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein D9E17_14695 ENOG4105F4P )-transporter D9E17_14700 ENOG4105KST dependent repressor D9E17_14710 ENOG4108I6E Sulfatase D9E17_14715 ENOG4108T1M outer membrane protein x D9E17_14725 ENOG4107AQZ Membrane D9E17_14735 ENOG4107R0W ABC transporter D9E17_14740 ENOG4105E5Q amino acid AbC transporter D9E17_14745 ENOG4105CDA abc transporter atp-binding protein D9E17_14750 ENOG4105D8X mechanosensitive ion channel D9E17_14760 ENOG4105ZY9 UPF0379 protein ybiM D9E17_14765 ENOG4108IU3 tonb-dependent siderophore receptor D9E17_14775 ENOG4105KSC Transcriptional regulator, TraR DksA family D9E17_14780 ENOG4105VR4 UPF0379 protein ybiJ D9E17_14785 ENOG4105DG4 malate L-lactate dehydrogenase D9E17_14790 ENOG4108MTB glycosyl transferase family D9E17_14795 ENOG4105DVT helicase D9E17_14800 ENOG4108UV1 cellular component movement D9E17_14805 ENOG4105C1J atp-dependent rna helicase D9E17_14810 ENOG4107MVR Transcriptional regulator D9E17_14820 ENOG4105CJ1 ABC, transporter D9E17_14825 ENOG4107QWP ABC-2 type transporter D9E17_14830 ENOG4107QWP ABC-2 type transporter D9E17_14835 ENOG4105I9U inner membrane protein ybhQ D9E17_14840 ENOG4105X23 Endonuclease Exonuclease phosphatase D9E17_14845 ENOG4105DZQ phospholipase D Transphosphatidylase D9E17_14850 ENOG4107UXM Membrane D9E17_14855 ENOG410733J conserved inner membrane protein D9E17_14860 ENOG4105HFZ Membrane D9E17_14865 ENOG4108ZAF Molybdopterin D9E17_14870 ENOG4105M00 molybdopterin converting factor, subunit 1 D9E17_14880 ENOG4108RIR Molybdenum cofactor biosynthesis protein D9E17_14890 ENOG4105CHW UPF0052 protein D9E17_14900 ENOG4105E78 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) D9E17_14905 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) D9E17_14910 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) D9E17_14920 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) D9E17_14925 ENOG4108V1U phospholipid-binding protein D9E17_14930 ENOG4105NBR Pectinesterase D9E17_14935 ENOG4107QM5 aconitate hydratase D9E17_14940 ENOG4107QPK )-transporter D9E17_14945 ENOG4105C7F AcnD-accessory protein PrpF D9E17_14950 ENOG4105F04 LysR family Transcriptional regulator D9E17_14960 ENOG4108K4B hydrolase D9E17_14965 ENOG4105CGB Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system (By similarity) D9E17_14970 ENOG4105E0C molybdate abc transporter D9E17_14975 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein D9E17_14980 ENOG410680R Protein of unknown function (DUF2592) D9E17_14985 ENOG4105F4R Transcriptional regulator mode D9E17_14990 ENOG4105DKW ABC transporter D9E17_14995 ENOG4105CMR udp-glucose 4-epimerase D9E17_15000 ENOG4105F0Z galactose-1-phosphate uridylyltransferase D9E17_15010 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) D9E17_15020 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) D9E17_15025 ENOG4105JND homeobox protein D9E17_15030 ENOG4105PGM cation diffusion facilitator family transporter D9E17_15035 ENOG4106Z1T Nicotinamide Mononucleotide Transporter D9E17_15080 ENOG4105UFD tol-pal system protein YbgF D9E17_15085 ENOG4105KCK Peptidoglycan-associated lipoprotein D9E17_15095 ENOG4108Z82 Cell envelope integrity inner membrane protein TolA D9E17_15100 ENOG4105M8F Biopolymer transport protein exbD tolR D9E17_15105 ENOG4105E02 MotA TolQ exbB proton channel D9E17_15110 ENOG4107YD3 Thioesterase D9E17_15115 ENOG4105KJB cyd operon protein YbgE D9E17_15125 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii D9E17_15130 ENOG4105C4M (Ubiquinol oxidase) subunit I D9E17_15140 ENOG4105DM4 PTS System D9E17_15145 ENOG4105FDP GntR family transcriptional regulator D9E17_15150 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha D9E17_15160 ENOG4105C7S Dehydrogenase D9E17_15165 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 D9E17_15170 ENOG4105E33 succinate dehydrogenase D9E17_15175 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) D9E17_15180 ENOG4105N1I succinate dehydrogenase, hydrophobic membrane anchor protein D9E17_15185 ENOG4108UTY succinate dehydrogenase, cytochrome b556 subunit D9E17_15195 ENOG4105BZN citrate synthase D9E17_15200 ENOG4106UBK fimbrial-like adhesin protein D9E17_15205 ENOG4106PG1 outer membrane usher protein D9E17_15210 ENOG4108TTM chaperone D9E17_15220 ENOG4108KK1 membrane protein AbrB duplication D9E17_15230 ENOG4105E7W lamb ycsf family protein D9E17_15235 ENOG4107R7A Allophanate hydrolase subunit 2 D9E17_15240 ENOG4105P4J Allophanate hydrolase, subunit 1 D9E17_15245 ENOG4107QNR UPF0135 protein D9E17_15250 ENOG4105DUX Transporter D9E17_15255 ENOG4105CVP deoxyribo-dipyrimidine photolyase D9E17_15260 ENOG4107SEY Conserved Protein D9E17_15280 ENOG4106R09 D9E17_15295 ENOG4105XIQ Protein of unknown function (DUF2517) D9E17_15320 ENOG4105C08 Histidine kinase D9E17_15325 ENOG4105EEX Two component transcriptional regulator (Winged helix family D9E17_15340 ENOG4105CXN decarboxylase D9E17_15345 ENOG4105D5Q Arginine ornithine antiporter D9E17_15365 ENOG4107QIX Phosphoglucomutase (EC 5.4.2.2 D9E17_15370 ENOG4107CDU Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated (By similarity) D9E17_15375 ENOG4105EV9 Alpha Beta Hydrolase D9E17_15380 ENOG4105NNH LexA regulated protein D9E17_15385 ENOG4105MHQ Low-potential electron donor to a number of redox enzymes (By similarity) D9E17_15395 ENOG41090R7 Ferric uptake D9E17_15400 ENOG4105GX6 (LipO)protein D9E17_15415 ENOG4105CI1 PTS System D9E17_15425 ENOG4105CE4 GlcNAc 6-P deacetylase D9E17_15430 ENOG4105E2R ROK family D9E17_15435 ENOG4105D4U had-superfamily hydrolase, subfamily iia D9E17_15440 ENOG4105CAQ asparagine synthetase D9E17_15480 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family D9E17_15490 ENOG4105C9A Phoh family D9E17_15500 ENOG4108JU5 Magnesium and cobalt efflux protein D9E17_15505 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) D9E17_15515 ENOG4107U91 Rhomboid family D9E17_15520 ENOG4107RP9 extracellular solute-binding protein, family 3 D9E17_15525 ENOG4105EAD ABC transporter D9E17_15530 ENOG4105DRP amino acid AbC transporter D9E17_15535 ENOG4105CDA abc transporter atp-binding protein D9E17_15540 ENOG4105DU0 nucleoside hydrolase D9E17_15545 ENOG4105F7F Chaperone D9E17_15550 ENOG4105QFC Hsc56 co-chaperone of HscC D9E17_15555 ENOG41069CF Protein of unknown function (DUF1266) D9E17_15560 ENOG4107JFD Sel1 repeat D9E17_15565 ENOG4105QFC Hsc56 co-chaperone of HscC D9E17_15570 ENOG41069CF Protein of unknown function (DUF1266) D9E17_15575 ENOG4105EUU Sel1 domain protein repeat-containing protein D9E17_15580 ENOG4107PAI alpha helical protein D9E17_15595 ENOG4105DJF DNA polymerase III, delta' subunit D9E17_15605 ENOG4108TGR phosphatase D9E17_15610 ENOG4105KEM Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) D9E17_15620 ENOG4105CJN penicillin-binding protein D9E17_15625 ENOG4105CNI cell division protein FtsW D9E17_15630 ENOG4105K6T rare lipoprotein A D9E17_15635 ENOG4105DZ1 carboxypeptidase D9E17_15650 ENOG41064T2 transcriptional regulator, lysR family D9E17_15660 ENOG410607N Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatE shares overlapping functions with TatA (By similarity) D9E17_15665 ENOG4107QPI nitrilase cyanide hydratase and apolipoprotein n-acyltransferase D9E17_15670 ENOG4107Z6W Protein CrcB homolog D9E17_15675 ENOG4105VEQ Cold shock protein D9E17_15680 ENOG41079UR PagP is required both for biosynthesis of hepta-acylated lipid A species containing palmitate and for resistance to cationic antimicrobial peptides (CAMPs). It catalyzes the transfer of a palmitate chain (16 0) from the sn-1 position of a glycerophospholipid to the free hydroxyl group of the (R)-3- hydroxymyristate chain at position 2 of lipid A (endotoxin) (By similarity) D9E17_15685 ENOG4105CEE C4-dicarboxylate transporter D9E17_15690 ENOG4106YYS transcriptional regulatory protein D9E17_15695 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism D9E17_15700 ENOG4105DUA (citrate (pro-3S)-lyase ligase D9E17_15710 ENOG4105CI0 Citrate lyase D9E17_15715 ENOG4105CHY citrate lyase, alpha D9E17_15730 ENOG4107QPK )-transporter D9E17_15735 ENOG4105KTS ribonuclease D9E17_15740 ENOG4105NXH GreA GreB family elongation factor D9E17_15745 ENOG4105E2A Dehydrogenase D9E17_15750 ENOG4108U51 Universal stress protein D9E17_15755 ENOG4108JU3 Alkyl hydroperoxide reductase D9E17_15760 ENOG4105D3R alkyl hydroperoxide reductase D9E17_15765 ENOG4108KHN disulfide isomerase, thiol-disulfide oxidase D9E17_15770 ENOG4105DQS Transcriptional regulator D9E17_15775 ENOG4105BZV Phosphoadenosine phosphosulfate reductase D9E17_15780 ENOG4105GTN ParB Domain Protein Nuclease D9E17_15785 ENOG4105CHM Aminotransferase D9E17_15790 ENOG4107SCQ Iron-containing alcohol dehydrogenase D9E17_15795 ENOG4105VCD cytoplasmic protein D9E17_15800 ENOG4105D22 carbon starvation protein D9E17_15805 ENOG4108TZA Required for optimal enterobactin synthesis. Acts as a proofreading enzyme that prevents EntB misacylation by hydrolyzing the thioester bound existing between EntB and wrongly charged molecules (By similarity) D9E17_15810 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase D9E17_15815 ENOG4105WQI isochorismatase D9E17_15820 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase D9E17_15825 ENOG4105E4F Isochorismate synthase D9E17_15830 ENOG4105PEC Iron-enterobactin transporter periplasmic binding protein D9E17_15840 ENOG4105DQ5 transport system permease protein D9E17_15845 ENOG4105TVJ transport system, permease D9E17_15850 ENOG4105E0A ABC, transporter D9E17_15855 ENOG4108QY5 Ferric enterobactin transport protein D9E17_15860 ENOG4105C0W non-ribosomal peptide synthetase D9E17_15865 ENOG41085A6 mbth domain-containing protein D9E17_15870 ENOG4105E93 esterase D9E17_15875 ENOG4107RNH Outer membrane receptor FepA D9E17_15880 ENOG4108TSE Transferase D9E17_15885 ENOG4108SER Transposase D9E17_15890 ENOG4107635 Hok Gef family protein D9E17_15910 ENOG4105WQ6 Membrane D9E17_15915 ENOG4105MSB protein, conserved in bacteria D9E17_15920 ENOG4108RCM Nitroreductase D9E17_15925 ENOG4105CUY Mechanosensitive ion channel D9E17_15930 ENOG4105C85 amino acid D9E17_15935 ENOG4108IJF Heavy metal efflux pump, CzcA D9E17_15940 ENOG4105EP1 Efflux transporter rnd family, mfp subunit D9E17_15945 ENOG410624V efflux system protein D9E17_15950 ENOG4105ENJ RND efflux system, outer membrane lipoprotein D9E17_15955 ENOG4105CK6 Two component transcriptional regulator (Winged helix family D9E17_15960 ENOG4105GR3 Histidine kinase D9E17_15965 ENOG4105CS6 Rhs element vgr protein D9E17_15970 ENOG410802X bacteriophage n4 adsorption protein b D9E17_15975 ENOG41090FC Bacteriophage N4 receptor, outer membrane subunit D9E17_15980 ENOG4105QUW D9E17_16010 ENOG4108ZI2 Fimbrial protein D9E17_16015 ENOG4108M66 Involved in regulation of length and mediation of adhesion of SfmA fimbriae (but not necessary for the production of fimbriae). Seems to be mannose binding adhesin (By similarity) D9E17_16020 ENOG4105CW0 outer membrane usher protein D9E17_16025 ENOG4108AF8 Chaperone D9E17_16030 ENOG4108WDE Fimbrial protein D9E17_16040 ENOG4105WQ3 Rna-binding protein D9E17_16045 ENOG4105S2T inner membrane protein YbcI D9E17_16055 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) D9E17_16065 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) D9E17_16070 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit D9E17_16075 ENOG4105C5B carbamate kinase D9E17_16080 ENOG4105G5A Protein of unknown function (DUF2877) D9E17_16085 ENOG4107REC cytoplasmic protein D9E17_16090 ENOG4107R1Q Membrane protein FdrA D9E17_16095 ENOG4105DG4 malate L-lactate dehydrogenase D9E17_16100 ENOG4105CE7 Amidase, hydantoinase carbamoylase family D9E17_16105 ENOG4105S0E allantoin catabolism protein D9E17_16110 ENOG4105BZW Glycerate kinase D9E17_16115 ENOG4105DTE Xanthine uracil vitamin C permease D9E17_16120 ENOG4105CD3 dihydroorotase D9E17_16130 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease D9E17_16135 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase D9E17_16140 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) D9E17_16145 ENOG41060W2 glyoxylate carboligase D9E17_16150 ENOG4108N16 Negative regulator of allantoin and glyoxylate utilization operons. Binds to the gcl promoter and to the allS- allA intergenic region D9E17_16155 ENOG4108Z2U ureidoglycolate hydrolase D9E17_16160 ENOG4107653 Transcriptional regulator D9E17_16165 ENOG4105CR7 Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA (By similarity) D9E17_16170 ENOG4105CV6 ABC transporter, permease D9E17_16175 ENOG4108I0Y (ABC) transporter D9E17_16180 ENOG4108UJV acyl-CoA thioesterase i D9E17_16185 ENOG4105E1F short-chain dehydrogenase reductase D9E17_16190 ENOG4107QR8 Thioredoxin D9E17_16195 ENOG4105C4B ABC transporter, permease D9E17_16200 ENOG41083J0 (ABC) transporter D9E17_16205 ENOG4107QX8 SPFH domain, Band 7 family protein D9E17_16210 ENOG4105G5H Membrane D9E17_16215 ENOG4108Z6Z Transcriptional regulator D9E17_16220 ENOG4107RY6 amino acid D9E17_16225 ENOG4105CSV Glutaminase D9E17_16230 ENOG4105C59 p-type ATPase D9E17_16235 ENOG41081XE plasmid maintenance system antidote protein, xre family D9E17_16245 ENOG4105MBR gumn family D9E17_16250 ENOG4108Z66 YbaK ebsC protein D9E17_16255 ENOG4105CGH 5'-nucleotidase D9E17_16260 ENOG4105EU0 Major facilitator Superfamily D9E17_16265 ENOG4105CKD glutathione-regulated potassium-efflux system protein D9E17_16270 ENOG4107RE1 Inosine-guanosine kinase D9E17_16295 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) D9E17_16310 ENOG4107QMP dna polymerase iii subunits gamma and tau D9E17_16320 ENOG4105WD1 Membrane D9E17_16325 ENOG4108URS primosomal replication protein n'' D9E17_16330 ENOG4106428 Protein of unknown function (DUF2496) D9E17_16335 ENOG4105EGS Mechanosensitive ion channel D9E17_16340 ENOG4108IG5 Transcriptional regulator D9E17_16345 ENOG4105C1P efflux transporter, rnd family, mfp subunit D9E17_16350 ENOG4105BZS acriflavin resistance protein D9E17_16355 ENOG4108UKR Biofilm formation regulator YbaJ D9E17_16360 ENOG4105KF5 hemolysin expression-modulating protein D9E17_16365 ENOG4108UW5 maltose o-acetyltransferase D9E17_16370 ENOG4105GSJ Inner membrane protein ylaC D9E17_16375 ENOG41066DG (EAL) domain protein D9E17_16380 ENOG4105KCV RNA signal recognition particle 4.5S RNA D9E17_16390 ENOG41080UX Methyltransferase D9E17_16395 ENOG4108MNP Glycoprotein polysaccharide metabolism D9E17_16400 ENOG4105C29 acyl-CoA thioesterase D9E17_16405 ENOG4105BZU Histidine kinase D9E17_16410 ENOG4108YZA Nitrogen regulatory protein pii D9E17_16415 ENOG4105BZ1 (ABC) transporter D9E17_16420 ENOG4105BZ1 (ABC) transporter D9E17_16425 ENOG4108XM1 transcriptional regulator AsnC family D9E17_16435 ENOG4108NFA extracellular solute-binding protein D9E17_16445 ENOG4108TGP Thioesterase superfamily protein D9E17_16450 ENOG41083P1 competence protein ComEA helix-hairpin-helix repeat protein D9E17_16455 ENOG4105EIN peptidylprolyl cis-trans isomerase D9E17_16460 ENOG4105K70 DNA-binding protein D9E17_16465 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) D9E17_16485 ENOG4105M85 Bola protein D9E17_16490 ENOG4105IEY (LipO)protein D9E17_16495 ENOG4105EYM Major Facilitator superfamily D9E17_16500 ENOG4105E2S oxidase) subunit II D9E17_16505 ENOG4105BZ9 Cytochrome C oxidase, subunit I D9E17_16510 ENOG4105CCU oxidase (Subunit III) D9E17_16515 ENOG41090KH cytochrome o ubiquinol oxidase (subunit iv) D9E17_16525 ENOG4107RDB Major Facilitator D9E17_16535 ENOG4108JZF Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) D9E17_16540 ENOG4107S0N DJ-1 family D9E17_16545 ENOG4105D8I Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity) D9E17_16555 ENOG4105CTB Polyprenyl synthetase D9E17_16565 ENOG4105CPC Aldo Keto reductase D9E17_16570 ENOG4108ZAI phosphatidylglycerophosphatase a D9E17_16575 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) D9E17_16585 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) D9E17_16590 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) D9E17_16600 ENOG4108KIC (LipO)protein D9E17_16605 ENOG4105DRB nucleoside-specific channel-forming protein D9E17_16610 ENOG4105N1F Hnh endonuclease D9E17_16615 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) D9E17_16620 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) D9E17_16625 ENOG4105VIE preprotein translocase, subunit YajC D9E17_16645 ENOG4107R28 alpha amylase, catalytic region D9E17_16650 ENOG4105C85 amino acid D9E17_16655 ENOG4105CWM branched-chain amino acid transport system II carrier protein D9E17_16660 ENOG4105BZU Histidine kinase D9E17_16665 ENOG4105CK6 Two component transcriptional regulator (Winged helix family D9E17_16670 ENOG4107RH8 nuclease SbcCD subunit D D9E17_16675 ENOG4105EYH Exonuclease D9E17_16680 ENOG4105F27 Major Facilitator D9E17_16685 ENOG4105DKQ ROK family D9E17_16710 ENOG4105HBA AroM protein D9E17_16715 ENOG4105SS3 D9E17_16725 ENOG4108UPT UPF0178 protein D9E17_16730 ENOG4105II7 pyrroline-5-carboxylate reductase D9E17_16735 ENOG4105BZU Histidine kinase D9E17_16740 ENOG4105VIF phosphate starvation-inducible protein D9E17_16745 ENOG4105G6Z alkaline phosphatase D9E17_16755 ENOG4105CPF Cell wall formation (By similarity) D9E17_16760 ENOG4105UNH Membrane D9E17_16765 ENOG4105FR5 inner membrane protein YaiY D9E17_16770 ENOG4107QS8 (LipO)protein D9E17_16775 ENOG4108DQG in Escherichia coli SbmA is involved in uptake of microcin J25 D9E17_16780 ENOG4107R6D beta-lactam binding protein AmpH D9E17_16785 ENOG4108PNB DNA-binding transcriptional regulator D9E17_16795 ENOG4105D52 delta-aminolevulinic acid dehydratase D9E17_16800 ENOG4105E2B Taurine dioxygenase D9E17_16805 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component D9E17_16810 ENOG4108IY8 ABC, transporter D9E17_16815 ENOG4106FTQ Taurine ABC transporter, periplasmic D9E17_16820 ENOG4107W19 lmbE family D9E17_16825 ENOG4108PBI Polysaccharide metabolism D9E17_16835 ENOG4105SRB Uncharacterized protein yaiO D9E17_16850 ENOG4105C4W S-formylglutathione hydrolase D9E17_16855 ENOG4105IUQ nucleoprotein polynucleotide-associated enzyme D9E17_16860 ENOG4108SC4 )-transporter D9E17_16875 ENOG4105IKQ hydratase D9E17_16885 ENOG4105MI0 Catalyzes the non-heme iron(II)-dependent oxidative cleavage of 2,3-dihydroxyphenylpropionic acid and 2,3- dihydroxicinnamic acid into 2-hydroxy-6-ketononadienedioate and 2- hydroxy-6-ketononatrienedioate, respectively (By similarity) D9E17_16895 ENOG4108K2P TRANSCRIPTIONal D9E17_16900 ENOG4105ETE Transcriptional regulator (LacI family D9E17_16905 ENOG4105CNT hydrolase family 2 D9E17_16910 ENOG4105U0F oligosaccharide H symporter, major facilitator superfamily (MFS) D9E17_16915 ENOG4108UW5 maltose o-acetyltransferase D9E17_16920 ENOG4105DJ2 Major Facilitator Superfamily D9E17_16925 ENOG4108V7B Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide (By similarity) D9E17_16930 ENOG4107B2H carbonic anhydrase D9E17_16935 ENOG4105DND Transcriptional regulator D9E17_16940 ENOG4105DZC cytosine deaminase D9E17_16945 ENOG4105DQW permease for cytosine purines, uracil, thiamine, allantoin D9E17_16950 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) D9E17_16955 ENOG4105DXD 2-methylcitrate dehydratase D9E17_16960 ENOG4105BZN citrate synthase D9E17_16965 ENOG4105CR4 methylisocitrate lyase D9E17_16970 ENOG4108JU7 Transcriptional regulator D9E17_16975 ENOG4105TDT uncharacterized protein yahO D9E17_16980 ENOG4105E82 cytochrome subunit of dehydrogenase D9E17_16995 ENOG4105DQ4 alcohol dehydrogenase D9E17_17000 ENOG4105DZC cytosine deaminase D9E17_17005 ENOG4105C5B carbamate kinase D9E17_17015 ENOG4107REC cytoplasmic protein D9E17_17020 ENOG4107R1Q Membrane protein FdrA D9E17_17025 ENOG4105N16 Protein of unknown function (DUF2877) D9E17_17030 ENOG4107SNB ankyrin repeat protein YahD D9E17_17035 ENOG4105SZ2 membrAne D9E17_17040 ENOG4108NUU Transcriptional regulator D9E17_17045 ENOG4105BZU Histidine kinase D9E17_17050 ENOG4105C94 Transporter D9E17_17075 ENOG4108ZZK Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source (By similarity) D9E17_17080 ENOG4107QR9 Iron-sulfur cluster binding protein D9E17_17085 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) D9E17_17090 ENOG4108K01 transcriptional regulator D9E17_17095 ENOG4107QN2 dihydrolipoyl dehydrogenase D9E17_17100 ENOG41066GK UPF0379 protein ykgI D9E17_17105 ENOG4108KBJ Inner membrane protein YkgB D9E17_17135 ENOG4105NRA 50s ribosomal protein l31 type b D9E17_17150 ENOG4106JB4 Represses expression of the flagellar master operon flhDC, and consequently prevents flagellum biosynthesis and motility. Acts by binding to the regulatory region of the flhDC operon D9E17_17165 ENOG4108N3D putative enzyme D9E17_17170 ENOG4106PYX Receptor D9E17_17175 ENOG4108UD7 cell wall organization D9E17_17180 ENOG4105PI0 Ferredoxin D9E17_17185 ENOG4105R3P Inner membrane protein yagU D9E17_17190 ENOG4107XKX isoquinoline 1-oxidoreductase, alpha subunit D9E17_17195 ENOG4105DIP Molybdopterin dehydrogenase FAD-binding D9E17_17200 ENOG4105C7W Xanthine dehydrogenase D9E17_17205 ENOG4107XAN XdhC and CoxI family D9E17_17220 ENOG4108NKV transcriptional regulator D9E17_17235 ENOG4105QYK bacteriophage lambda Bor protein homolog D9E17_17245 ENOG4105KUS lysozyme D9E17_17250 ENOG4105QFS Lysis protein S homolog from lambdoid prophage D9E17_17260 ENOG4105HRS Antitermination protein D9E17_17275 ENOG4105RWQ Protein of unknown function (DUF1364) D9E17_17280 ENOG410757E Protein NinE homolog from lambdoid prophage DLP12 D9E17_17285 ENOG4108V2F protein ybcN in lambdoid DLP12 prophage regi D9E17_17380 ENOG4105FCK Membrane D9E17_17400 ENOG4105CIN aminoacyl-histidine dipeptidase D9E17_17405 ENOG4108S2Y peptide Chain Release factor D9E17_17415 ENOG4108HYG acetyltransferase D9E17_17420 ENOG41065DM this blockage is overcome by subsequent expression of antitoxin YafN. Overexpression causes cleavage of a number of mRNAs in a ribosome-dependent fashion. YafO binding to the 50S ribosomal subunit in the translation complex induces mRNA cleavage 3' to the region protected by the ribosome D9E17_17425 ENOG4105UG9 Antitoxin of the YafO-YafN toxin-antitoxin system D9E17_17430 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) D9E17_17440 ENOG4107RD7 Flagellar Motor Protein, MotA D9E17_17470 ENOG410804A Flagellar hook-associated 2 domain-containing protein D9E17_17480 ENOG4105I03 Flagellin D9E17_17495 ENOG4105DTJ flagellar hook-associated protein D9E17_17505 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj D9E17_17520 ENOG4105CGA flagellar basal-body rod protein FlgG D9E17_17525 ENOG4108KPB Flagellar basal-body rod protein FlgF D9E17_17530 ENOG4105BZE flagellar hook protein, FlgE D9E17_17540 ENOG4108ZC9 flagellar basal-body rod protein flgc D9E17_17545 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) D9E17_17575 ENOG4107ZIC Glycerol-3-phosphate cytidylyltransferase D9E17_17585 ENOG4108JIR Flagellum-specific ATP synthase D9E17_17595 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) D9E17_17600 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) D9E17_17610 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family D9E17_17620 ENOG4105DD5 Flagellar motor switch protein D9E17_17625 ENOG4105CN7 Flagellar biosynthetic protein FliP D9E17_17630 ENOG4105VS8 Flagellar biosynthetic protein fliq D9E17_17635 ENOG4105D19 Role in flagellar biosynthesis (By similarity) D9E17_17650 ENOG4108UK5 Transposase D9E17_17655 ENOG4108YS0 lipoprotein YafL D9E17_17660 ENOG4105F7V ErfK ybiS ycfS ynhG family protein D9E17_17665 ENOG4105E7A Glutamine amidotransferase D9E17_17675 ENOG4107QPN acyl-Coa dehydrogenase D9E17_17680 ENOG4108WN0 inhibitor of vertebrate lysozyme D9E17_17685 ENOG4105CZ7 nitrilase cyanide hydratase and apolipoprotein n-acyltransferase D9E17_17690 ENOG410600T transposase D9E17_17720 ENOG4105GMB type VI secretion system effector, hcp1 family D9E17_17735 ENOG410600K aminopeptidase D9E17_17745 ENOG4107RZZ dna polymerase iii epsilon subunit D9E17_17755 ENOG4105D1A Methyltransferase D9E17_17760 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) D9E17_17765 ENOG4105E9H Lytic Murein transglycosylase D9E17_17770 ENOG4105F2W methyltransferase D9E17_17780 ENOG4105HEI LysR family (Transcriptional regulator D9E17_17785 ENOG4105CV8 reductase D9E17_17820 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase D9E17_17825 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) D9E17_17830 ENOG4108UMI ABC transporter, permease D9E17_17835 ENOG4105D01 (LipO)protein D9E17_17840 ENOG4108R8X outer membrane lipoprotein D9E17_17845 ENOG4108R96 Methyltransferase, YaeB family D9E17_17855 ENOG4108UY0 (LipO)protein D9E17_17860 ENOG4107EII Lipoprotein involved with copper homeostasis and adhesion D9E17_17865 ENOG4108YZN class I peptide chain release factor D9E17_17870 ENOG4108VWS Yaeq family D9E17_17880 ENOG4105M1T rho-binding antiterminator D9E17_17885 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) D9E17_17890 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase D9E17_17895 ENOG4105CXN decarboxylase D9E17_17905 ENOG4105C0B DNA polymerase III (alpha subunit) D9E17_17930 ENOG4105D7M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) D9E17_17935 ENOG4108RFI Molecular chaperone that interacts specifically with outer membrane proteins, thus maintaining the solubility of early folding intermediates during passage through the periplasm (By similarity) D9E17_17945 ENOG4105DZP Membrane-associated zinc metalloprotease D9E17_17950 ENOG4105KNE Phosphatidate cytidylyltransferase D9E17_17955 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) D9E17_17960 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) D9E17_17985 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) D9E17_18000 ENOG4105DIN metallophosphoesterase D9E17_18015 ENOG4108IXP Carbohydrate diacid transcriptional activator CdaR D9E17_18020 ENOG4105C0H protease D9E17_18035 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) D9E17_18040 ENOG4105EN6 Membrane D9E17_18065 ENOG4105S6R Iron-hydroxamate transporter permease subunit D9E17_18070 ENOG4105J76 Periplasmic binding protein D9E17_18075 ENOG4105E0A ABC, transporter D9E17_18080 ENOG4105E0K tonB-dependent siderophore receptor D9E17_18085 ENOG4105BZ4 penicillin-binding protein D9E17_18090 ENOG4105CQ7 ATP-dependent helicase D9E17_18095 ENOG4107XID 2'-5' rna ligase D9E17_18105 ENOG4108V7X Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters D9E17_18115 ENOG4105DJ0 Poly(A) Polymerase D9E17_18120 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase D9E17_18130 ENOG4108VEV chaperone D9E17_18135 ENOG4105CW0 outer membrane usher protein D9E17_18140 ENOG4108XEY fimbrial-like adhesin protein D9E17_18145 ENOG4105SYG Fimbrial protein D9E17_18165 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) D9E17_18170 ENOG4108A32 Transposase D9E17_18180 ENOG4107BJW polysaccharide deacetylase D9E17_18185 ENOG4108YTN IIa component D9E17_18190 ENOG4105E3A (ABC) transporter D9E17_18195 ENOG4105DA5 (ABC) transporter D9E17_18200 ENOG41077A9 carbonic anhydrase D9E17_18205 ENOG4108UGV hypoxanthine phosphoribosyltransferase D9E17_18210 ENOG4105DZG Dehydrogenase D9E17_18215 ENOG4105E3B Multicopper oxidase D9E17_18220 ENOG4108ZRK uncharacterized protein yacC D9E17_18240 ENOG4107QIJ Aconitate hydratase 2 D9E17_18245 ENOG4108NST exported protein D9E17_18250 ENOG4107QN2 dihydrolipoyl dehydrogenase D9E17_18255 ENOG4107QSN dihydrolipoamide acetyltransferase D9E17_18260 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) D9E17_18265 ENOG41073TP transcriptional regulator D9E17_18270 ENOG4105C85 amino acid D9E17_18275 ENOG4106A72 regulatory protein AmpE D9E17_18280 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase D9E17_18285 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase D9E17_18290 ENOG4108ZUW Major pilin subunit D9E17_18295 ENOG4107QHF type ii secretion system protein e D9E17_18300 ENOG4105D7Q type ii secretion system D9E17_18310 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) D9E17_18325 ENOG4105M6F mutator MutT protein D9E17_18345 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) D9E17_18350 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) D9E17_18355 ENOG4105K7E Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity) D9E17_18360 ENOG4105CPF Cell wall formation (By similarity) D9E17_18375 ENOG4105CNI cell division protein FtsW D9E17_18380 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) D9E17_18390 ENOG4108EQQ Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity) D9E17_18395 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) D9E17_18400 ENOG4105CJN penicillin-binding protein D9E17_18405 ENOG41063Y6 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) D9E17_18420 ENOG4107B7Y DNA-binding transcriptional regulator FruR D9E17_18430 ENOG4108ZP8 Acetolactate synthase small subunit D9E17_18435 ENOG4105C7K acetolactate synthase D9E17_18445 ENOG41064T2 transcriptional regulator, lysR family D9E17_18460 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) D9E17_18475 ENOG4105S8Q sugar efflux transporter D9E17_18485 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) D9E17_18490 ENOG4105DP9 ABC transporter D9E17_18495 ENOG4106SMU thiamine transporter membrane protein D9E17_18505 ENOG4108KF1 Membrane D9E17_18510 ENOG41063TF transcriptional regulator (AraC D9E17_18515 ENOG4105EF1 ribulokinase D9E17_18525 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase D9E17_18530 ENOG4105CQ2 DNA polymerase D9E17_18540 ENOG4105D3G Pseudouridine synthase D9E17_18545 ENOG41066UG Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host (By similarity) D9E17_18550 ENOG4105E7H involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity) D9E17_18555 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) D9E17_18580 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) D9E17_18590 ENOG4108MXQ glutathione-regulated potassium-efflux system ancillary protein KefF D9E17_18595 ENOG4105C54 Major Facilitator superfamily D9E17_18600 ENOG4105IBM Could be part of an electron transfer system required for anaerobic carnitine reduction. Could be a 3Fe-4S cluster- containing protein D9E17_18605 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase D9E17_18640 ENOG4105CEY Amp-dependent synthetase and ligase D9E17_18645 ENOG4106YT9 Enoyl-CoA hydratase D9E17_18655 ENOG4108XNW Transcriptional activatory protein CaiF D9E17_18660 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain D9E17_18665 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain D9E17_18685 ENOG41090X3 Peptidyl-prolyl cis-trans isomerase D9E17_18695 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) D9E17_18700 ENOG4105DTN riboflavin biosynthesis protein ribF D9E17_18705 ENOG410647N response to DNA damage stimulus D9E17_18730 ENOG41063Z6 transcriptional regulator, lysR family D9E17_18745 ENOG4105WI6 cell killing protein encoded within cryptic prophage D9E17_18750 ENOG4108SER Transposase D9E17_18770 ENOG4108QUJ UPF0174 protein YaaW D9E17_18775 ENOG4106HK8 GPR1 FUN34 yaaH family protein D9E17_18780 ENOG4108RIR Molybdenum cofactor biosynthesis protein D9E17_18790 ENOG4105BZG amino acid carrier protein D9E17_18795 ENOG4105D1Q UPF0246 protein D9E17_18800 ENOG41062C6 Protein of unknown function (DUF2502) D9E17_18805 ENOG4105D98 threonine synthase D9E17_18815 ENOG4105CFH Aspartokinase D9E17_18825 ENOG4106FVC RNA methyltransferase D9E17_18830 ENOG410759A D9E17_18835 ENOG41065U4 response regulator D9E17_18845 ENOG4105EB3 Histidine kinase D9E17_18850 ENOG4105E3W Two component transcriptional regulator (Winged helix family D9E17_18855 ENOG4108RH0 Crea protein D9E17_18860 ENOG4105UEI Transcriptional Regulator AraC Family D9E17_18870 ENOG4108K16 Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) D9E17_18880 ENOG4107SC1 transglycosylase D9E17_18885 ENOG4105C5H ABC transporter D9E17_18890 ENOG4107VZS Nicotinamide-nucleotide adenylyltransferase D9E17_18895 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) D9E17_18900 ENOG4105EAC phosphoserine phosphatase D9E17_18905 ENOG4107RMF Catalyzes both the ATP-dependent activation of exogenously supplied lipoate to lipoyl-AMP and the transfer of the activated lipoyl onto the lipoyl domains of lipoate-dependent enzymes (By similarity) D9E17_18940 ENOG4105G0K glycine radical enzyme YjjI family D9E17_18945 ENOG41076CZ activating enzyme D9E17_18950 ENOG4105EYA deoxyribonuclease D9E17_18955 ENOG4108NRW Phospholipase, patatin family D9E17_18965 ENOG4105K3G Periplasmic Protein D9E17_18975 ENOG4106FE3 DNA repair D9E17_18995 ENOG4105FKG DNA packaging protein D9E17_19010 ENOG4105SZK Rz endopeptidase from lambdoid prophage DLP12 D9E17_19025 ENOG4105QFS Lysis protein S homolog from lambdoid prophage D9E17_19035 ENOG4108R7K Metal Dependent Phosphohydrolase D9E17_19055 ENOG4105C8A Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF- 1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP (By similarity) D9E17_19060 ENOG4105PAD Hydrolase D9E17_19065 ENOG4105KEG ribosomal-protein-alanine acetyltransferase D9E17_19070 ENOG4108WPU DNA polymerase III subunit psi D9E17_19075 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) D9E17_19095 ENOG4105YBH Protein of unknown function (DUF1435) D9E17_19100 ENOG4108819 ferric iron reductase D9E17_19105 ENOG4108T94 DNA-binding transcriptional activator BglJ D9E17_19110 ENOG4108N8T regulatoR D9E17_19115 ENOG4105DWK Membrane D9E17_19120 ENOG4107XM3 UPF0442 protein D9E17_19130 ENOG4106CVF DNA replication protein D9E17_19135 ENOG4105RI1 glycoprotein receptor D9E17_19140 ENOG4107RES phosphoglycerol transferase I D9E17_19145 ENOG4105CPQ Dehydrogenase D9E17_19150 ENOG410617M Transcriptional regulator D9E17_19155 ENOG4108I5G Major Facilitator superfamily D9E17_19160 ENOG4105C8Q Methyl-accepting chemotaxis D9E17_19165 ENOG4108V8F Transcriptional regulator, MarR family D9E17_19170 ENOG4105ERH Fumarylacetoacetate hydrolase D9E17_19175 ENOG4105C26 Dehydrogenase D9E17_19180 ENOG4107THI 3,4-dihydroxyphenylacetate 2,3-dioxygenase D9E17_19210 ENOG4105EFA 4-hydroxyphenylacetate D9E17_19215 ENOG4107UWN reductase D9E17_19220 ENOG4105D22 carbon starvation protein D9E17_19225 ENOG4105VCD cytoplasmic protein D9E17_19230 ENOG4105CKI cobalamin synthesis protein D9E17_19250 ENOG4105CBP Major Facilitator D9E17_19260 ENOG41074DU domain protein D9E17_19265 ENOG4108P2H Inner membrane protein YjiG D9E17_19270 ENOG4105DYB Isoaspartyl dipeptidase D9E17_19275 ENOG4107YNJ LysR family Transcriptional regulator D9E17_19295 ENOG4105C6F GntR Family Transcriptional Regulator D9E17_19300 ENOG4105DEI Mannitol dehydrogenase D9E17_19310 ENOG4107EFN gluconate transport system permease 3 D9E17_19315 ENOG410643X FIMH SUBUNIT MANNOSE-sensitive type 1 fimbrial adhesin D9E17_19350 ENOG4108SF5 RNA Polymerase D9E17_19355 ENOG4108S3W Anti-feci sigma factor, fecr D9E17_19360 ENOG4105GAV receptor D9E17_19365 ENOG4108HUF Transporter D9E17_19370 ENOG4105DQ5 transport system permease protein D9E17_19375 ENOG4108IHU transport system permease protein D9E17_19380 ENOG4105E0A ABC, transporter D9E17_19395 ENOG4105PBD transposase, IS3 IS911 family protein D9E17_19415 ENOG4105DQ4 alcohol dehydrogenase D9E17_19420 ENOG4105D7A ATP-binding protein D9E17_19425 ENOG4108K5H permease YjgP YjgQ family protein D9E17_19430 ENOG4108M8S permease YjgP YjgQ family protein D9E17_19440 ENOG4105MYG DNA polymerase iii, chi subunit D9E17_19445 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) D9E17_19450 ENOG4108M3P Membrane D9E17_19455 ENOG4108MJ3 acetyltransferase D9E17_19460 ENOG4105KQT Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome (By similarity) D9E17_19480 ENOG4105XEP YhcH YjgK YiaL family protein D9E17_19485 ENOG4108XFH Transcriptional regulator D9E17_19490 ENOG4105F6U Short-chain dehydrogenase reductase Sdr D9E17_19495 ENOG4108UQ8 endoribonuclease L-psp D9E17_19500 ENOG41077AM PyrBI operon attenuator D9E17_19515 ENOG4105KME endoribonuclease L-psp D9E17_19520 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic D9E17_19530 ENOG4105D4X repressor D9E17_19535 ENOG4105C5Y PTS System D9E17_19540 ENOG4105CG3 alpha amylase, catalytic region D9E17_19545 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase D9E17_19550 ENOG4108RDD Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine (By similarity) D9E17_19560 ENOG4105CMS peptidase U62, modulator of DNA gyrase D9E17_19570 ENOG4105DFU Cell wall formation (By similarity) D9E17_19580 ENOG41062B0 ABC transporter, permease D9E17_19585 ENOG4107R9N ABC transporter D9E17_19590 ENOG4105C2J ABC transporter D9E17_19595 ENOG4107R5U Periplasmic binding protein LacI transcriptional regulator D9E17_19600 ENOG4105F0N pyrophosphate phospho-hydrolase D9E17_19605 ENOG4108ZHD aig2 family D9E17_19610 ENOG4105MA0 exported protein D9E17_19615 ENOG4105CFU surface antigen D9E17_19625 ENOG4105C37 (CBS) domain D9E17_19630 ENOG41061GZ Protein of unknown function (DUF1107) D9E17_19635 ENOG4108UUE Transcriptional regulator D9E17_19640 ENOG4108RNI 3'(2')5'-bisphosphate nucleotidase D9E17_19645 ENOG4107RNS bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase 3'-nucleotidase periplasmic D9E17_19650 ENOG4105KVH Transcriptional regulator D9E17_19655 ENOG4105ECR NmrA family D9E17_19660 ENOG4105DXC membrane D9E17_19670 ENOG4105C85 amino acid D9E17_19675 ENOG4108V1T peptidylprolyl cis-trans isomerase D9E17_19685 ENOG4105FHY Opacity-associated protein A D9E17_19695 ENOG4105CHR reductase D9E17_19705 ENOG4105E39 Enoyl-CoA hydratase D9E17_19710 ENOG4107R0K CoA transferase having broad substrate specificity for short-chain acyl-CoA thioesters with the activity decreasing when the length of the carboxylic acid chain exceeds four carbons (By similarity) D9E17_19715 ENOG4107S3R L-aspartate oxidase D9E17_19720 ENOG41069H7 transport system small permease component D9E17_19725 ENOG4105CG6 trap dicarboxylate transporter dctm subunit D9E17_19730 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit D9E17_19740 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) D9E17_19755 ENOG4105KIT UPF0379 protein yjfY D9E17_19780 ENOG410907W The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in ascorbate transport D9E17_19785 ENOG4105CZC PTS system ascorbate-specific transporter subunit IIC D9E17_19800 ENOG4108MXZ Esterase D9E17_19805 ENOG4105WSB biofilm stress and motility protein A D9E17_19810 ENOG4105S17 UPF0379 protein yjfN D9E17_19815 ENOG4105CSU acyl-Coa dehydrogenase D9E17_19820 ENOG4106032 Glutathionylspermidine synthase D9E17_19825 ENOG4108KXT Conserved Protein D9E17_19830 ENOG4105Z6B inner membrane protein yjfl D9E17_19835 ENOG4107VNS Protein of unknown function (DUF2491) D9E17_19840 ENOG4108P9J Phage shock protein A D9E17_19845 ENOG4105FUX Conserved Protein D9E17_19850 ENOG4105C2N RNA methyltransferase TrmH family group 3 D9E17_19855 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) D9E17_19875 ENOG4105EPW hflc protein D9E17_19880 ENOG4107QJR hflk protein D9E17_19885 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) D9E17_19890 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) D9E17_19905 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase D9E17_19910 ENOG4105K8N protein family UPF0079, ATPase D9E17_19915 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) D9E17_19920 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) D9E17_19960 ENOG4105EGS Mechanosensitive ion channel D9E17_19965 ENOG4106CG8 Inner membrane protein YjeO D9E17_19970 ENOG4106V5W D9E17_19975 ENOG4107SC7 Inner membrane transporter yjeM D9E17_19980 ENOG4105CAP With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P (By similarity) D9E17_19985 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) D9E17_19990 ENOG4105E33 succinate dehydrogenase D9E17_20005 ENOG41066YJ Beta-lactamase D9E17_20010 ENOG4105QNF Outer membrane lipoprotein D9E17_20015 ENOG4105KPY Small multidrug resistance protein D9E17_20020 ENOG4106BSU Entericidin B D9E17_20025 ENOG4106HKS Entericidin EcnA/B family D9E17_20035 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein D9E17_20040 ENOG4105MTB Uncharacterized protein YjeJ D9E17_20045 ENOG4108ZVF (LipO)protein D9E17_20060 ENOG4105DVH amino acid D9E17_20065 ENOG4108YH1 overproduction of this protein in Escherichia coli inhibits the F plasmid-mediated exclusion of bacteriophage T7 D9E17_20070 ENOG4108IJ0 Aspartate ammonia-lyase D9E17_20075 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter D9E17_20085 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) D9E17_20090 ENOG4108SIC Transcriptional regulator D9E17_20100 ENOG4108M3R transcriptional activator CadC D9E17_20105 ENOG4105D5Q Arginine ornithine antiporter D9E17_20110 ENOG4105CXN decarboxylase D9E17_20115 ENOG4105DUX Transporter D9E17_20120 ENOG4105CRK lysyL-tRNA synthetase D9E17_20135 ENOG410830R acetyltransferase D9E17_20140 ENOG4105VR1 Pfam:DUF1271 D9E17_20145 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism D9E17_20150 ENOG4108MRH transcriptional regulatory protein D9E17_20155 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter D9E17_20160 ENOG4107GFK fumarate D9E17_20165 ENOG4108R5S membrane D9E17_20175 ENOG4105F8D glycoside hydrolase family 4 D9E17_20180 ENOG4108K2B transcriptional regulator D9E17_20185 ENOG4105CXN decarboxylase D9E17_20190 ENOG4106ZGR Transcriptional regulator D9E17_20200 ENOG4105D5Q Arginine ornithine antiporter D9E17_20205 ENOG4105DIJ Phosphoethanolamine transferase D9E17_20210 ENOG4105XJC Two component transcriptional regulator (Winged helix family D9E17_20215 ENOG4105ECM Sensor protein basS pmrB D9E17_20225 ENOG4105CSH Transporter D9E17_20230 ENOG4108YIV D9E17_20235 ENOG4108F5E vimentin D9E17_20240 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA D9E17_20245 ENOG4108SQ4 Glyoxalase Bleomycin resistance protein (Dioxygenase D9E17_20250 ENOG4105D5T phosphonate abc transporter D9E17_20255 ENOG4105EHI Phosphonate ABC transporter, periplasmic D9E17_20265 ENOG4107RJJ Transcriptional regulator D9E17_20270 ENOG4105KQZ Phosphonate C-P lyase system protein PhnG D9E17_20275 ENOG4105KZ6 phosphonate C-P lyase system protein PhnH D9E17_20280 ENOG4105EKV Phosphonate metabolism protein D9E17_20285 ENOG4105FT8 Phosphonate metabolism D9E17_20290 ENOG4105ENV phosphonate C-P lyase system protein PhnK D9E17_20295 ENOG4105HRV phosphonate c-p lyase system protein phnl D9E17_20300 ENOG4105FD8 phosphonate metabolism protein PhnM D9E17_20305 ENOG4105MFQ Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP) (By similarity) D9E17_20310 ENOG410849A acetyltransferase, (GNAT) family D9E17_20315 ENOG4107SA6 carbon-phosphorus lyase complex accessory protein D9E17_20320 ENOG4106ZVZ Escherichia coli IMT2125 genomic chromosome, IMT2125 D9E17_20325 ENOG4108YZG isomerase D9E17_20330 ENOG4105NYY transcriptional regulator, RpiR D9E17_20335 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator D9E17_20340 ENOG4105C2J ABC transporter D9E17_20345 ENOG4105CNN ABC, transporter D9E17_20350 ENOG4105UP7 3-epimerase D9E17_20355 ENOG4107TFG D-allose kinase D9E17_20360 ENOG4105EUZ Beta-lactamase domain protein D9E17_20365 ENOG4106833 D9E17_20370 ENOG4105J12 Multidrug resistance protein mdtN D9E17_20375 ENOG4108MI0 Resistance protein D9E17_20380 ENOG4105ETP RND efflux system, outer membrane lipoprotein D9E17_20390 ENOG41082ND Uncharacterized protein yjcO D9E17_20395 ENOG4105CK2 sodium dicarboxylate symporter D9E17_20400 ENOG4108W0S formate-dependent nitrite reductase complex D9E17_20410 ENOG4108QKW cytochrome c-type biogenesis protein D9E17_20415 ENOG4105DVI reductase, NrfD D9E17_20420 ENOG4105D3S 4Fe-4S Ferredoxin, iron-sulfur binding domain protein D9E17_20425 ENOG4105JJ8 Cytochrome c nitrite reductase, pentaheme subunit D9E17_20435 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) D9E17_20440 ENOG41062QD Membrane D9E17_20455 ENOG4105EEQ Na H antiporter D9E17_20460 ENOG4105C7N Xanthine uracil vitamin C permease D9E17_20465 ENOG4108Z4X TRANSCRIPTIONal D9E17_20470 ENOG4108W3Q Transcriptional regulator D9E17_20475 ENOG4108M8H domain protein D9E17_20480 ENOG4105PMV Membrane D9E17_20485 ENOG4108UUM single-stranded DNA-binding protein D9E17_20490 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) D9E17_20495 ENOG4105MSB protein, conserved in bacteria D9E17_20505 ENOG4105F0S class B acid phosphatase D9E17_20515 ENOG4105CGF Aromatic amino acid aminotransferase D9E17_20520 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) D9E17_20525 ENOG4105CDU Replicative dna helicase D9E17_20530 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein D9E17_20535 ENOG4105P4Z Phage shock protein G D9E17_20540 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) D9E17_20555 ENOG4105MYN Zinc uptake regulation protein D9E17_20560 ENOG4105VDW Csbd family D9E17_20565 ENOG4107R73 Mate efflux family protein D9E17_20575 ENOG41080IJ Diacylglycerol kinase D9E17_20600 ENOG4107W52 maltose operon periplasmic protein D9E17_20610 ENOG4108IJ9 (ABC) transporter D9E17_20615 ENOG4107FKK extracellular solute-binding protein family 1 D9E17_20620 ENOG4105D56 permease protein D9E17_20625 ENOG4105EG2 ABC transporter, permease D9E17_20630 ENOG4107QNK )-transporter D9E17_20645 ENOG4105E3R (LipO)protein D9E17_20650 ENOG4108Q9C Periplasmic Protein D9E17_20655 ENOG4108MDC (LipO)protein D9E17_20670 ENOG4105CFH Aspartokinase D9E17_20675 ENOG4108ZR5 Conserved Protein D9E17_20680 ENOG4105FE9 pseudouridine synthase D9E17_20690 ENOG4105EAM Na Pi-cotransporter D9E17_20695 ENOG4105C3R Methionine synthase D9E17_20700 ENOG41069M3 Transcriptional regulator D9E17_20710 ENOG4105VS7 Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation (By similarity) D9E17_20715 ENOG4108I9X Isocitrate lyase D9E17_20720 ENOG4107QP3 malate synthase g D9E17_20725 ENOG4105CVG Homoserine O-transsuccinylase D9E17_20730 ENOG4105K5X acetyltransferase D9E17_20765 ENOG4105C12 Phosphoribosylglycinamide synthetase D9E17_20770 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family D9E17_20775 ENOG4105BZU Histidine kinase D9E17_20780 ENOG4105JBU Binds zinc. Could be an important component of the zinc- balancing mechanism D9E17_20785 ENOG4108T8B Protein of unknown function (DUF1481) D9E17_20790 ENOG4105K70 DNA-binding protein D9E17_20795 ENOG4105R2J Conserved Protein D9E17_20830 ENOG4105D06 uba thif-type nad fad binding protein D9E17_20835 ENOG4105WHD thiamine biosynthesis protein ThiS D9E17_20845 ENOG4105D41 biosynthesis protein thiH D9E17_20850 ENOG410645W Thiamin biosynthesis protein ThiH D9E17_20885 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) D9E17_20890 ENOG4105PM1 preprotein translocase subunit SecE D9E17_20925 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase D9E17_20930 ENOG4105D4A Cell wall formation (By similarity) D9E17_20960 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) D9E17_20965 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) D9E17_20975 ENOG4108Y73 Membrane D9E17_20980 ENOG4105EJ2 Transcriptional regulator D9E17_20990 ENOG4105C5Q Transcriptional regulator D9E17_21000 ENOG4105CAS nag kinase D9E17_21005 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase D9E17_21020 ENOG4105DIJ Phosphoethanolamine transferase D9E17_21025 ENOG4106R3P AraC family transcriptional regulator D9E17_21030 ENOG4108XCZ PTS System D9E17_21035 ENOG4108AHH pyruvate formate lyase II activase D9E17_21040 ENOG4105C6N Formate acetyltransferase D9E17_21045 ENOG4108YRF PTS System D9E17_21050 ENOG4105DM4 PTS System D9E17_21055 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) D9E17_21060 ENOG4107T9Z Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) D9E17_21065 ENOG4105DCT glycerol dehydrogenase D9E17_21075 ENOG4108Q5Y Membrane D9E17_21080 ENOG4105C1X Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity (By similarity) D9E17_21085 ENOG4105SYT Methylenetetrahydrofolate reductase D9E17_21090 ENOG4105CFH Aspartokinase D9E17_21095 ENOG4105C28 cystathionine D9E17_21105 ENOG4107S01 Repressor protein MetJ D9E17_21120 ENOG4105CNA YD repeat protein D9E17_21120 ENOG4105CNA YD repeat protein D9E17_21130 ENOG4105C25 Primosomal protein n' D9E17_21135 ENOG4105ETE Transcriptional regulator (LacI family D9E17_21140 ENOG41063M6 Cell Division Protein D9E17_21150 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) D9E17_21155 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase D9E17_21170 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) D9E17_21180 ENOG4105CBT Fructose-1,6-bisphosphatase D9E17_21185 ENOG4105DP0 ferredoxin-NADP reductase D9E17_21195 ENOG41065TG regulatoR D9E17_21200 ENOG4108VTS Membrane D9E17_21205 ENOG4105EBK exported protein D9E17_21220 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein D9E17_21235 ENOG4105FMW periplasmic D9E17_21240 ENOG4105E3W Two component transcriptional regulator (Winged helix family D9E17_21245 ENOG4105E0F Histidine kinase D9E17_21250 ENOG4108RPX mosc domain containing protein D9E17_21260 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) D9E17_21305 ENOG41064BA PTS system, fructose-specific, IIA component D9E17_21310 ENOG4105DM4 PTS System D9E17_21315 ENOG4105CN9 Peptidase m42 family protein D9E17_21320 ENOG4106C3V frv operon regulatory protein D9E17_21325 ENOG4108V87 frv operon regulatory protein D9E17_21340 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein D9E17_21345 ENOG4108MG3 formate dehydrogenase D9E17_21355 ENOG41068KX affects formate dehydrogenase-N D9E17_21360 ENOG4106UEE Transcriptional regulator D9E17_21365 ENOG4105SUU thioesterase domain D9E17_21380 ENOG4105EJU HAD-superfamily hydrolase subfamily IA variant 3 D9E17_21385 ENOG4105E98 transcriptional regulator DeoR family D9E17_21390 ENOG4108MGF sugar kinase D9E17_21395 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase D9E17_21400 ENOG4105D2M Aldolase D9E17_21405 ENOG4107QKS N-acylglucosamine 2-epimerase D9E17_21410 ENOG4107WI4 Aldose-1-epimerase D9E17_21415 ENOG4105CJQ hydrolase, family 31 D9E17_21420 ENOG4105CT4 transporter D9E17_21425 ENOG4105CT4 transporter D9E17_21430 ENOG4108KUC Outer membrane channel protein that allows an efficient diffusion of low-molecular-weight solutes such as small sugars and tetraglycine. However, the specific substrate recognized by the OmpL channel is D9E17_21435 ENOG4105R9B Major Facilitator D9E17_21440 ENOG4108KHF Resistance protein D9E17_21445 ENOG4108K85 Transcriptional regulator D9E17_21455 ENOG4105C5F glutamine synthetase D9E17_21460 ENOG4105CUX Signal transduction histidine kinase D9E17_21465 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family D9E17_21470 ENOG4106FIY D9E17_21475 ENOG4105D4P Coproporphyrinogen iii oxidase D9E17_21490 ENOG4105C2M dna polymerase I D9E17_21500 ENOG4106HNH Acyl-transferase D9E17_21510 ENOG4108Z33 Thiol disulfide Interchange Protein D9E17_21515 ENOG4105E27 serine threonine protein kinase D9E17_21520 ENOG4105PC1 Conserved Protein D9E17_21525 ENOG4105C6R Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) D9E17_21530 ENOG4105FNP Molybdopterin-guanine dinucleotide biosynthesis protein b D9E17_21560 ENOG4108RR8 protoporphyrinogen oxidase D9E17_21565 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) D9E17_21570 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein D9E17_21585 ENOG4105CHU acetyl-coa acetyltransferase D9E17_21590 ENOG4107QK7 reductase D9E17_21595 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) D9E17_21600 ENOG4105MDZ Transcriptional activator rfaH D9E17_21605 ENOG4105F8V Hydrolase, tatD family D9E17_21610 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) D9E17_21615 ENOG4105X8U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity) D9E17_21620 ENOG4105WKS Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) D9E17_21630 ENOG4105JC1 sterol-binding domain protein D9E17_21640 ENOG4105CGY Dna recombination protein D9E17_21645 ENOG4108I5U Uridine phosphorylase D9E17_21650 ENOG4105CDZ Carboxymethylenebutenolidase (EC 3.1.1.45) D9E17_21655 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) D9E17_21660 ENOG4105DZ2 Transcriptional regulator D9E17_21665 ENOG4105EMK carboxylate amino acid amine transporter D9E17_21670 ENOG4105DQF Hydrolase D9E17_21675 ENOG4108EUD Lysophospholipase D9E17_21690 ENOG4105C9U ATP-dependent DNA helicase RecQ D9E17_21695 ENOG4105HDD phospholipase D9E17_21700 ENOG4108VUY thioesterase Superfamily protein D9E17_21705 ENOG4105FR1 rard protein D9E17_21710 ENOG4106WR8 Inner membrane protein YigG D9E17_21715 ENOG4105NRM Membrane D9E17_21720 ENOG4107QUT magnesium and cobalt transport protein CorA D9E17_21725 ENOG4108T58 Mg2 transport protein CorA D9E17_21730 ENOG4105C4R Atp-dependent dna helicase D9E17_21735 ENOG4105DFC had-superfamily hydrolase, subfamily ia, variant D9E17_21745 ENOG4105CT0 Protein of unknown function, DUF484 D9E17_21755 ENOG4105S7Z (LipO)protein D9E17_21770 ENOG4107T0K Adenylate cyclase D9E17_21780 ENOG41076E6 Uroporphyrinogen-III Synthase D9E17_21785 ENOG4105ECF c-methyltransferase D9E17_21790 ENOG410601J HemY protein D9E17_21795 ENOG4105C4X radical SAM domain protein D9E17_21820 ENOG4105C85 amino acid D9E17_21835 ENOG4105F18 Catalyzes the synthesis of Und-PP-GlcNAc-ManNAcA-Fuc4NAc (Lipid III), the third lipid-linked intermediate involved in ECA synthesis (By similarity) D9E17_21840 ENOG4105EGZ biosynthesis protein D9E17_21845 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase D9E17_21850 ENOG4108WJ1 acetyltransferase D9E17_21855 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) D9E17_21860 ENOG4105C1B dTDP-glucose 4-6-dehydratase D9E17_21865 ENOG4108IJ1 Dehydrogenase D9E17_21870 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase D9E17_21875 ENOG4105SFE lipopolysaccharide biosynthesis protein D9E17_21880 ENOG4105ESV Glycosyl transferase, family 4 D9E17_21895 ENOG4105K63 Thioredoxin D9E17_21910 ENOG4105C4R Atp-dependent dna helicase D9E17_21920 ENOG4105KQ5 peptidylprolyl cis-trans isomerase D9E17_21930 ENOG4105EMY transcriptional regulator D9E17_21935 ENOG4105C7B Threonine dehydratase D9E17_21945 ENOG4105CM2 brancheD-chain amino acid aminotransferase D9E17_21950 ENOG4105P3Y Acetolactate synthase 2 regulatory subunit D9E17_21970 ENOG4105C0P Mg chelatase subunit ChlI D9E17_21975 ENOG4108WFC UPF0438 protein yifE D9E17_22015 ENOG4107EJG GntR family transcriptional regulator D9E17_22020 ENOG4105C0R drug resistance transporter emrb qaca subfamily D9E17_22025 ENOG4105ETE Transcriptional regulator (LacI family D9E17_22030 ENOG4108RVA ribokinase D9E17_22035 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator D9E17_22040 ENOG4105CNN ABC, transporter D9E17_22045 ENOG4105C2J ABC transporter D9E17_22065 ENOG4105EV2 VWA domain protein interacting with AAA ATPase D9E17_22075 ENOG4108VVK transcriptional Regulator, AsnC D9E17_22080 ENOG4105QTB Flavodoxin D9E17_22095 ENOG4105GXX Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit I associates with the membrane and may be involved with cation translocation D9E17_22105 ENOG4105KY6 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) D9E17_22150 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) D9E17_22155 ENOG4107QMV Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity) D9E17_22160 ENOG4105C8U phosphate abc transporter D9E17_22165 ENOG4105E2Z phosphate ABC transporter (Permease D9E17_22170 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) D9E17_22175 ENOG4108UTW Plays a role in the regulation of phosphate uptake D9E17_22195 ENOG4105C5Y PTS System D9E17_22200 ENOG4105CS2 ec 3.2.1.21 D9E17_22205 ENOG4108P68 Outer membrane porin D9E17_22210 ENOG4105DYC esterase D9E17_22215 ENOG4107VKM 6-phosphogluconolactonase D9E17_22230 ENOG4107UB3 HAD-superfamily hydrolase subfamily IA variant 3 D9E17_22235 ENOG4105C7N Xanthine uracil vitamin C permease D9E17_22240 ENOG4108YYH Nadph-dependent fmn reductase D9E17_22245 ENOG4105E8Q phosphopantetheinyl transferase D9E17_22260 ENOG4108P6C Tryptophan transporter of low affinity D9E17_22345 ENOG4105BZU Histidine kinase D9E17_22375 ENOG4108VSE mercuric transport protein D9E17_22380 ENOG4105W1Y Transcriptional regulator D9E17_22410 ENOG4108KTG Membrane protein, drug metabolite transporter D9E17_22460 ENOG4106CQM replication D9E17_22475 ENOG4105ESI atpase involved in dna repair D9E17_22485 ENOG4107SCJ type I restriction enzyme EcoKI subunit R D9E17_22500 ENOG4107CBI conjugal transfer fertility inhibition protein D9E17_22540 ENOG41074AV Hok/gef family D9E17_22555 ENOG4105FEQ ParB domain protein nuclease D9E17_22650 ENOG4108NC2 Outer membrane protease D9E17_22680 ENOG4106JVB Replication Protein D9E17_22720 ENOG4105DIK (ABC) transporter D9E17_22725 ENOG4105CC5 ABC transporter D9E17_22730 ENOG4105CC5 ABC transporter D9E17_22775 ENOG4105EZN Cobyrinic acid ac-diamide synthase D9E17_22780 ENOG4106JGA Chromosome (Plasmid) partitioning protein, ParB D9E17_22845 ENOG4105QYK bacteriophage lambda Bor protein homolog D9E17_22880 ENOG4105E93 esterase D9E17_22885 ENOG4105NIV Esterase D9E17_22890 ENOG4107RNH Outer membrane receptor FepA D9E17_22995 ENOG4105M0J Toxic component of a toxin-antitoxin (TA) module. A D9E17_23000 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) D9E17_23030 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) D9E17_23055 ENOG4105EMU Dehydrogenase D9E17_23105 ENOG4107W31 Pentapeptide repeat protein