locus-tag class description ADZ27_00010 ENOG4105CFH Aspartokinase ADZ27_00020 ENOG4105D98 threonine synthase ADZ27_00030 ENOG41062C6 Protein of unknown function (DUF2502) ADZ27_00040 ENOG4105BZG amino acid carrier protein ADZ27_00050 ENOG4108RIR Molybdenum cofactor biosynthesis protein ADZ27_00055 ENOG4106HK8 GPR1 FUN34 yaaH family protein ADZ27_00060 ENOG4108QUJ UPF0174 protein YaaW ADZ27_00075 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) ADZ27_00080 ENOG4108SER Transposase ADZ27_00090 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) ADZ27_00095 ENOG41063Z6 transcriptional regulator, lysR family ADZ27_00115 ENOG410647N response to DNA damage stimulus ADZ27_00120 ENOG4105DTN riboflavin biosynthesis protein ribF ADZ27_00135 ENOG41090X3 Peptidyl-prolyl cis-trans isomerase ADZ27_00165 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain ADZ27_00170 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain ADZ27_00180 ENOG4108XNW Transcriptional activatory protein CaiF ADZ27_00190 ENOG4106YT9 Enoyl-CoA hydratase ADZ27_00225 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase ADZ27_00230 ENOG4105IBM Could be part of an electron transfer system required for anaerobic carnitine reduction. Could be a 3Fe-4S cluster- containing protein ADZ27_00235 ENOG4105C54 Major Facilitator superfamily ADZ27_00250 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) ADZ27_00275 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) ADZ27_00280 ENOG4105E7H involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity) ADZ27_00285 ENOG41066UG Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host (By similarity) ADZ27_00295 ENOG4105D3G Pseudouridine synthase ADZ27_00305 ENOG4105CQ2 DNA polymerase ADZ27_00310 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase ADZ27_00315 ENOG4105CAC Catalyzes the conversion of L-arabinose to L-ribulose (By similarity) ADZ27_00320 ENOG4105EF1 ribulokinase ADZ27_00325 ENOG41063TF transcriptional regulator (AraC ADZ27_00330 ENOG4108KF1 Membrane ADZ27_00335 ENOG4107T0D ABC, transporter ADZ27_00340 ENOG4106SMU thiamine transporter membrane protein ADZ27_00345 ENOG4105DP9 ABC transporter ADZ27_00360 ENOG4105S8Q sugar efflux transporter ADZ27_00375 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) ADZ27_00390 ENOG41064T2 transcriptional regulator, lysR family ADZ27_00395 ENOG4105C7K acetolactate synthase ADZ27_00400 ENOG4108ZP8 Acetolactate synthase small subunit ADZ27_00410 ENOG4107B7Y DNA-binding transcriptional regulator FruR ADZ27_00415 ENOG4108V6E Cell division protein mraZ ADZ27_00425 ENOG41063Y6 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) ADZ27_00430 ENOG4105CJN penicillin-binding protein ADZ27_00435 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) ADZ27_00440 ENOG4108EQQ Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity) ADZ27_00450 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) ADZ27_00455 ENOG4105CNI cell division protein FtsW ADZ27_00470 ENOG4105CPF Cell wall formation (By similarity) ADZ27_00475 ENOG4105K7E Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity) ADZ27_00480 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) ADZ27_00485 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) ADZ27_00505 ENOG4105M6F mutator MutT protein ADZ27_00525 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) ADZ27_00535 ENOG4105D7Q type ii secretion system ADZ27_00540 ENOG4107QHF type ii secretion system protein e ADZ27_00545 ENOG4108ZUW Major pilin subunit ADZ27_00555 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase ADZ27_00560 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase ADZ27_00565 ENOG4106A72 regulatory protein AmpE ADZ27_00570 ENOG4105C85 amino acid ADZ27_00575 ENOG41073TP transcriptional regulator ADZ27_00580 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) ADZ27_00585 ENOG4107QSN dihydrolipoamide acetyltransferase ADZ27_00590 ENOG4107QN2 dihydrolipoyl dehydrogenase ADZ27_00595 ENOG4108NST exported protein ADZ27_00600 ENOG4107QIJ Aconitate hydratase 2 ADZ27_00620 ENOG4108ZRK uncharacterized protein yacC ADZ27_00625 ENOG4105E3B Multicopper oxidase ADZ27_00630 ENOG4105DZG Dehydrogenase ADZ27_00635 ENOG4108UGV hypoxanthine phosphoribosyltransferase ADZ27_00640 ENOG41077A9 carbonic anhydrase ADZ27_00645 ENOG4105DA5 (ABC) transporter ADZ27_00650 ENOG4105E3A (ABC) transporter ADZ27_00655 ENOG4108YTN IIa component ADZ27_00660 ENOG4107BJW polysaccharide deacetylase ADZ27_00670 ENOG4108A32 Transposase ADZ27_00685 ENOG4105P0Q fimbrial-like protein YadC ADZ27_00690 ENOG4105SN2 fimbrial-like adhesin protein ADZ27_00695 ENOG4105SYG Fimbrial protein ADZ27_00700 ENOG4108XEY fimbrial-like adhesin protein ADZ27_00705 ENOG4105CW0 outer membrane usher protein ADZ27_00710 ENOG4108VEV chaperone ADZ27_00720 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase ADZ27_00725 ENOG4105DJ0 Poly(A) Polymerase ADZ27_00735 ENOG4108V7X Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters ADZ27_00745 ENOG4107XID 2'-5' rna ligase ADZ27_00750 ENOG4105CQ7 ATP-dependent helicase ADZ27_00760 ENOG4105BZ4 penicillin-binding protein ADZ27_00765 ENOG4105E0K tonB-dependent siderophore receptor ADZ27_00770 ENOG4105E0A ABC, transporter ADZ27_00775 ENOG4105J76 Periplasmic binding protein ADZ27_00780 ENOG4105S6R Iron-hydroxamate transporter permease subunit ADZ27_00800 ENOG4105EN6 Membrane ADZ27_00805 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) ADZ27_00820 ENOG4105C0H protease ADZ27_00825 ENOG4108IXP Carbohydrate diacid transcriptional activator CdaR ADZ27_00835 ENOG4105DIN metallophosphoesterase ADZ27_00850 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) ADZ27_00875 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) ADZ27_00880 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) ADZ27_00885 ENOG4105KNE Phosphatidate cytidylyltransferase ADZ27_00890 ENOG4105DZP Membrane-associated zinc metalloprotease ADZ27_00900 ENOG4108RFI Molecular chaperone that interacts specifically with outer membrane proteins, thus maintaining the solubility of early folding intermediates during passage through the periplasm (By similarity) ADZ27_00905 ENOG4105D7M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) ADZ27_00930 ENOG4105C0B DNA polymerase III (alpha subunit) ADZ27_00940 ENOG4105CXN decarboxylase ADZ27_00945 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase ADZ27_00950 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) ADZ27_00955 ENOG4105M1T rho-binding antiterminator ADZ27_00965 ENOG4108VWS Yaeq family ADZ27_00970 ENOG4108YZN class I peptide chain release factor ADZ27_00975 ENOG4107EII Lipoprotein involved with copper homeostasis and adhesion ADZ27_00980 ENOG4108UY0 (LipO)protein ADZ27_00990 ENOG4108R96 Methyltransferase, YaeB family ADZ27_00995 ENOG4108R8X outer membrane lipoprotein ADZ27_01000 ENOG4105D01 (LipO)protein ADZ27_01005 ENOG4108UMI ABC transporter, permease ADZ27_01010 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) ADZ27_01015 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase ADZ27_01050 ENOG4105CV8 reductase ADZ27_01055 ENOG4105HEI LysR family (Transcriptional regulator ADZ27_01065 ENOG4105F2W methyltransferase ADZ27_01070 ENOG4105E9H Lytic Murein transglycosylase ADZ27_01075 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) ADZ27_01080 ENOG4105D1A Methyltransferase ADZ27_01090 ENOG4107RZZ dna polymerase iii epsilon subunit ADZ27_01100 ENOG410600K aminopeptidase ADZ27_01115 ENOG410600T transposase ADZ27_01120 ENOG4105CZ7 nitrilase cyanide hydratase and apolipoprotein n-acyltransferase ADZ27_01125 ENOG4108WN0 inhibitor of vertebrate lysozyme ADZ27_01130 ENOG4107QPN acyl-Coa dehydrogenase ADZ27_01140 ENOG4105E7A Glutamine amidotransferase ADZ27_01145 ENOG4105F7V ErfK ybiS ycfS ynhG family protein ADZ27_01150 ENOG4105VXN addiction module toxin, RelE StbE family ADZ27_01155 ENOG4105QHH Antitoxin component of a toxin-antitoxin (TA) module. A labile antitoxin that counteracts the effect of the YafQ toxin. YafQ and DinJ together bind their own promoter, and by analogy to other TA modules probably repress its expression ADZ27_01160 ENOG4108YS0 lipoprotein YafL ADZ27_01165 ENOG4108UK5 Transposase ADZ27_01180 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) ADZ27_01185 ENOG4105UG9 Antitoxin of the YafO-YafN toxin-antitoxin system ADZ27_01190 ENOG41065DM this blockage is overcome by subsequent expression of antitoxin YafN. Overexpression causes cleavage of a number of mRNAs in a ribosome-dependent fashion. YafO binding to the 50S ribosomal subunit in the translation complex induces mRNA cleavage 3' to the region protected by the ribosome ADZ27_01195 ENOG4108HYG acetyltransferase ADZ27_01205 ENOG4108S2Y peptide Chain Release factor ADZ27_01210 ENOG4105CIN aminoacyl-histidine dipeptidase ADZ27_01230 ENOG4105FCK Membrane ADZ27_01250 ENOG4108X3P Toxic component of a toxin-antitoxin (TA) module. Overexpression results in inhibition of growth in liquid cultures ADZ27_01260 ENOG4108XS9 dna repair protein ADZ27_01265 ENOG4106549 Antirestriction protein ADZ27_01270 ENOG4106ZN7 UPF0401 protein YkfF ADZ27_01275 ENOG4106J9S Prophage ADZ27_01290 ENOG4106H6R UPF0380 protein ADZ27_01295 ENOG4108MXD gtp-binding protein ADZ27_01300 ENOG4108PZW LysR family Transcriptional regulator ADZ27_01305 ENOG4105PBD transposase, IS3 IS911 family protein ADZ27_01310 ENOG4105F9F transposase ADZ27_01335 ENOG4105F2I Transposase ADZ27_01340 ENOG4108IQI permease ADZ27_01345 ENOG4107QK5 Homocysteine s-methyltransferase ADZ27_01350 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) ADZ27_01360 ENOG4108MBK is1 orf2 ADZ27_01380 ENOG4108KQ5 Integrase catalytic subunit ADZ27_01385 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) ADZ27_01390 ENOG4105C01 Dihydroxy-acid dehydratase ADZ27_01395 ENOG4105CT4 transporter ADZ27_01400 ENOG4105DSG hydrolase family 43 ADZ27_01405 ENOG4107HP6 Transcriptional regulator ADZ27_01410 ENOG4105DBV ornithine carbamoyltransferase ADZ27_01415 ENOG4108MBK is1 orf2 ADZ27_01425 ENOG4105JXR Protein of unknown function (DUF3296) ADZ27_01430 ENOG410693A DNA-binding protein ADZ27_01435 ENOG4106GND ADZ27_01440 ENOG4105F2I Transposase ADZ27_01445 ENOG410792U CP4-6 prophage ADZ27_01450 ENOG41067CV Integrase ADZ27_01465 ENOG4107XAN XdhC and CoxI family ADZ27_01470 ENOG4105C7W Xanthine dehydrogenase ADZ27_01475 ENOG4105DIP Molybdopterin dehydrogenase FAD-binding ADZ27_01480 ENOG4107XKX isoquinoline 1-oxidoreductase, alpha subunit ADZ27_01485 ENOG4105R3P Inner membrane protein yagU ADZ27_01490 ENOG4105PI0 Ferredoxin ADZ27_01495 ENOG4108UD7 cell wall organization ADZ27_01500 ENOG4106PYX Receptor ADZ27_01505 ENOG4108N3D putative enzyme ADZ27_01515 ENOG4108GWT fimbrillin MatB ADZ27_01520 ENOG4106JB4 Represses expression of the flagellar master operon flhDC, and consequently prevents flagellum biosynthesis and motility. Acts by binding to the regulatory region of the flhDC operon ADZ27_01535 ENOG4105NRA 50s ribosomal protein l31 type b ADZ27_01550 ENOG41090WB Transposase is3 is911 ADZ27_01565 ENOG4108KBJ Inner membrane protein YkgB ADZ27_01570 ENOG41066GK UPF0379 protein ykgI ADZ27_01575 ENOG4107QN2 dihydrolipoyl dehydrogenase ADZ27_01580 ENOG4108K01 transcriptional regulator ADZ27_01585 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) ADZ27_01590 ENOG4107QR9 Iron-sulfur cluster binding protein ADZ27_01595 ENOG4108ZZK Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source (By similarity) ADZ27_01610 ENOG4105CZ6 Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine (By similarity) ADZ27_01615 ENOG4105C26 Dehydrogenase ADZ27_01620 ENOG4108MHR Repressor involved in choline regulation of the bet genes (By similarity) ADZ27_01625 ENOG4105C94 Transporter ADZ27_01635 ENOG4105BZU Histidine kinase ADZ27_01640 ENOG4108NUU Transcriptional regulator ADZ27_01645 ENOG4105SZ2 membrAne ADZ27_01650 ENOG4107SNB ankyrin repeat protein YahD ADZ27_01655 ENOG4105N16 Protein of unknown function (DUF2877) ADZ27_01660 ENOG4107R1Q Membrane protein FdrA ADZ27_01665 ENOG4107REC cytoplasmic protein ADZ27_01675 ENOG4105C5B carbamate kinase ADZ27_01680 ENOG4105DZC cytosine deaminase ADZ27_01685 ENOG4105DQ4 alcohol dehydrogenase ADZ27_01700 ENOG4105E82 cytochrome subunit of dehydrogenase ADZ27_01705 ENOG4105TDT uncharacterized protein yahO ADZ27_01710 ENOG4108JU7 Transcriptional regulator ADZ27_01715 ENOG4105CR4 methylisocitrate lyase ADZ27_01720 ENOG4105BZN citrate synthase ADZ27_01725 ENOG4105DXD 2-methylcitrate dehydratase ADZ27_01730 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) ADZ27_01735 ENOG4105DQW permease for cytosine purines, uracil, thiamine, allantoin ADZ27_01740 ENOG4105DZC cytosine deaminase ADZ27_01745 ENOG4105DND Transcriptional regulator ADZ27_01750 ENOG4107B2H carbonic anhydrase ADZ27_01755 ENOG4108V7B Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide (By similarity) ADZ27_01760 ENOG4105DJ2 Major Facilitator Superfamily ADZ27_01765 ENOG4108UW5 maltose o-acetyltransferase ADZ27_01770 ENOG4105U0F oligosaccharide H symporter, major facilitator superfamily (MFS) ADZ27_01775 ENOG4105CNT hydrolase family 2 ADZ27_01780 ENOG4105ETE Transcriptional regulator (LacI family ADZ27_01785 ENOG4108K2P TRANSCRIPTIONal ADZ27_01790 ENOG4105E2Q 3-(3-hydroxy-phenyl)propionate hydroxylase ADZ27_01795 ENOG4105MI0 Catalyzes the non-heme iron(II)-dependent oxidative cleavage of 2,3-dihydroxyphenylpropionic acid and 2,3- dihydroxicinnamic acid into 2-hydroxy-6-ketononadienedioate and 2- hydroxy-6-ketononatrienedioate, respectively (By similarity) ADZ27_01800 ENOG4106HB6 Alpha beta hydrolase ADZ27_01805 ENOG4105IKQ hydratase ADZ27_01820 ENOG4108SC4 )-transporter ADZ27_01825 ENOG4105IUQ nucleoprotein polynucleotide-associated enzyme ADZ27_01830 ENOG4105C4W S-formylglutathione hydrolase ADZ27_01835 ENOG4108I9Z alcohol dehydrogenase ADZ27_01845 ENOG4105SRB Uncharacterized protein yaiO ADZ27_01860 ENOG4108ZQS transposase ADZ27_01865 ENOG4108MVM Transposase ADZ27_01870 ENOG4108PBI Polysaccharide metabolism ADZ27_01875 ENOG4107W19 lmbE family ADZ27_01880 ENOG4106FTQ Taurine ABC transporter, periplasmic ADZ27_01885 ENOG4108IY8 ABC, transporter ADZ27_01890 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component ADZ27_01895 ENOG4105E2B Taurine dioxygenase ADZ27_01900 ENOG4105D52 delta-aminolevulinic acid dehydratase ADZ27_01920 ENOG41090WB Transposase is3 is911 ADZ27_01930 ENOG4108PNB DNA-binding transcriptional regulator ADZ27_01935 ENOG4107R6D beta-lactam binding protein AmpH ADZ27_01945 ENOG4108DQG in Escherichia coli SbmA is involved in uptake of microcin J25 ADZ27_01950 ENOG4107QS8 (LipO)protein ADZ27_01955 ENOG4105FR5 inner membrane protein YaiY ADZ27_01960 ENOG4105UNH Membrane ADZ27_01965 ENOG4105CPF Cell wall formation (By similarity) ADZ27_01980 ENOG4105G6Z alkaline phosphatase ADZ27_01985 ENOG4105VIF phosphate starvation-inducible protein ADZ27_01990 ENOG4105BZU Histidine kinase ADZ27_01995 ENOG4105II7 pyrroline-5-carboxylate reductase ADZ27_02010 ENOG4105SS3 ADZ27_02020 ENOG4105HBA AroM protein ADZ27_02040 ENOG4105DKQ ROK family ADZ27_02045 ENOG4105F27 Major Facilitator ADZ27_02050 ENOG4105EYH Exonuclease ADZ27_02055 ENOG4107RH8 nuclease SbcCD subunit D ADZ27_02060 ENOG4105CK6 Two component transcriptional regulator (Winged helix family ADZ27_02065 ENOG4105BZU Histidine kinase ADZ27_02070 ENOG4105CWM branched-chain amino acid transport system II carrier protein ADZ27_02075 ENOG4105C85 amino acid ADZ27_02080 ENOG4107R28 alpha amylase, catalytic region ADZ27_02100 ENOG4105VIE preprotein translocase, subunit YajC ADZ27_02105 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) ADZ27_02110 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) ADZ27_02115 ENOG4105N1F Hnh endonuclease ADZ27_02125 ENOG4105DRB nucleoside-specific channel-forming protein ADZ27_02130 ENOG4108KIC (LipO)protein ADZ27_02140 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) ADZ27_02145 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) ADZ27_02155 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) ADZ27_02160 ENOG4108ZAI phosphatidylglycerophosphatase a ADZ27_02165 ENOG4105CPC Aldo Keto reductase ADZ27_02175 ENOG4105CTB Polyprenyl synthetase ADZ27_02190 ENOG4107S0N DJ-1 family ADZ27_02195 ENOG4108JZF Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) ADZ27_02205 ENOG4107RDB Major Facilitator ADZ27_02215 ENOG41090KH cytochrome o ubiquinol oxidase (subunit iv) ADZ27_02220 ENOG4105CCU oxidase (Subunit III) ADZ27_02225 ENOG4105BZ9 Cytochrome C oxidase, subunit I ADZ27_02230 ENOG4105E2S oxidase) subunit II ADZ27_02235 ENOG4105EYM Major Facilitator superfamily ADZ27_02240 ENOG4105IEY (LipO)protein ADZ27_02245 ENOG4105M85 Bola protein ADZ27_02270 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) ADZ27_02275 ENOG4105K70 DNA-binding protein ADZ27_02280 ENOG4105EIN peptidylprolyl cis-trans isomerase ADZ27_02285 ENOG41083P1 competence protein ComEA helix-hairpin-helix repeat protein ADZ27_02290 ENOG4108TGP Thioesterase superfamily protein ADZ27_02300 ENOG4108NFA extracellular solute-binding protein ADZ27_02310 ENOG4108XM1 transcriptional regulator AsnC family ADZ27_02315 ENOG4105BZ1 (ABC) transporter ADZ27_02320 ENOG4105BZ1 (ABC) transporter ADZ27_02325 ENOG4108YZA Nitrogen regulatory protein pii ADZ27_02330 ENOG4105BZU Histidine kinase ADZ27_02335 ENOG4105C29 acyl-CoA thioesterase ADZ27_02340 ENOG4108MNP Glycoprotein polysaccharide metabolism ADZ27_02345 ENOG41080UX Methyltransferase ADZ27_02350 ENOG4105KCV RNA signal recognition particle 4.5S RNA ADZ27_02355 ENOG41066DG (EAL) domain protein ADZ27_02360 ENOG4105GSJ Inner membrane protein ylaC ADZ27_02365 ENOG4108UW5 maltose o-acetyltransferase ADZ27_02370 ENOG4105KF5 hemolysin expression-modulating protein ADZ27_02375 ENOG4108UKR Biofilm formation regulator YbaJ ADZ27_02380 ENOG4105BZS acriflavin resistance protein ADZ27_02385 ENOG4105C1P efflux transporter, rnd family, mfp subunit ADZ27_02390 ENOG4108IG5 Transcriptional regulator ADZ27_02395 ENOG4105EGS Mechanosensitive ion channel ADZ27_02405 ENOG4106428 Protein of unknown function (DUF2496) ADZ27_02410 ENOG4108URS primosomal replication protein n'' ADZ27_02415 ENOG4105WD1 Membrane ADZ27_02425 ENOG4107QMP dna polymerase iii subunits gamma and tau ADZ27_02440 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) ADZ27_02460 ENOG4107RE1 Inosine-guanosine kinase ADZ27_02465 ENOG4105CKD glutathione-regulated potassium-efflux system protein ADZ27_02470 ENOG4105EU0 Major facilitator Superfamily ADZ27_02475 ENOG4105CGH 5'-nucleotidase ADZ27_02480 ENOG4108Z66 YbaK ebsC protein ADZ27_02485 ENOG4105MBR gumn family ADZ27_02490 ENOG41081XE plasmid maintenance system antidote protein, xre family ADZ27_02495 ENOG4105C59 p-type ATPase ADZ27_02500 ENOG4105CSV Glutaminase ADZ27_02505 ENOG4107RY6 amino acid ADZ27_02510 ENOG4108Z6Z Transcriptional regulator ADZ27_02515 ENOG4105G5H Membrane ADZ27_02520 ENOG4107QX8 SPFH domain, Band 7 family protein ADZ27_02525 ENOG41083J0 (ABC) transporter ADZ27_02530 ENOG4105C4B ABC transporter, permease ADZ27_02535 ENOG4107QR8 Thioredoxin ADZ27_02540 ENOG4105E1F short-chain dehydrogenase reductase ADZ27_02545 ENOG4108UJV acyl-CoA thioesterase i ADZ27_02550 ENOG4108I0Y (ABC) transporter ADZ27_02555 ENOG4105CV6 ABC transporter, permease ADZ27_02560 ENOG4105CNA YD repeat protein ADZ27_02580 ENOG4108J1Q ADZ27_02590 ENOG4107653 Transcriptional regulator ADZ27_02600 ENOG4108N16 Negative regulator of allantoin and glyoxylate utilization operons. Binds to the gcl promoter and to the allS- allA intergenic region ADZ27_02605 ENOG41060W2 glyoxylate carboligase ADZ27_02610 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) ADZ27_02615 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase ADZ27_02620 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease ADZ27_02630 ENOG4105DTE Xanthine uracil vitamin C permease ADZ27_02635 ENOG4105BZW Glycerate kinase ADZ27_02640 ENOG4105S0E allantoin catabolism protein ADZ27_02645 ENOG4105CE7 Amidase, hydantoinase carbamoylase family ADZ27_02650 ENOG4105DG4 malate L-lactate dehydrogenase ADZ27_02655 ENOG4107R1Q Membrane protein FdrA ADZ27_02660 ENOG4107REC cytoplasmic protein ADZ27_02665 ENOG4105G5A Protein of unknown function (DUF2877) ADZ27_02670 ENOG4105C5B carbamate kinase ADZ27_02675 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit ADZ27_02680 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) ADZ27_02690 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) ADZ27_02700 ENOG4105S2T inner membrane protein YbcI ADZ27_02705 ENOG4105WQ3 Rna-binding protein ADZ27_02715 ENOG4108WDE Fimbrial protein ADZ27_02720 ENOG4108AF8 Chaperone ADZ27_02725 ENOG4105CW0 outer membrane usher protein ADZ27_02730 ENOG4108M66 Involved in regulation of length and mediation of adhesion of SfmA fimbriae (but not necessary for the production of fimbriae). Seems to be mannose binding adhesin (By similarity) ADZ27_02735 ENOG4108ZI2 Fimbrial protein ADZ27_02740 ENOG4108Q9V regulatoR ADZ27_02755 ENOG4105F2I Transposase ADZ27_02765 ENOG4105QFS Lysis protein S homolog from lambdoid prophage ADZ27_02770 ENOG4105KUS lysozyme ADZ27_02775 ENOG4105SZK Rz endopeptidase from lambdoid prophage DLP12 ADZ27_02780 ENOG4105QYK bacteriophage lambda Bor protein homolog ADZ27_02800 ENOG4106YSC ADZ27_02810 ENOG4105FKG DNA packaging protein ADZ27_02815 ENOG4105UZW Tail fiber assembly protein ADZ27_02820 ENOG4108WF3 methyltransferase ADZ27_02830 ENOG4108MIW Induces the synthesis of acid phosphatase (AppA) and several other polypeptides (such as AppBC) during the deceleration phase of growth. It also acts as a transcriptional repressor for one group of proteins that are synthesized preferentially in exponential growth and for one group synthesized only in the stationary phase. Also involved in the stabilization of the sigma stress factor RpoS during stress conditions ADZ27_02835 ENOG4108NC2 Outer membrane protease ADZ27_02850 ENOG4105QUW ADZ27_02855 ENOG41090FC Bacteriophage N4 receptor, outer membrane subunit ADZ27_02860 ENOG410802X bacteriophage n4 adsorption protein b ADZ27_02865 ENOG4105GR3 Histidine kinase ADZ27_02870 ENOG4105CK6 Two component transcriptional regulator (Winged helix family ADZ27_02875 ENOG4105ENJ RND efflux system, outer membrane lipoprotein ADZ27_02880 ENOG410624V efflux system protein ADZ27_02885 ENOG4105EP1 Efflux transporter rnd family, mfp subunit ADZ27_02890 ENOG4108IJF Heavy metal efflux pump, CzcA ADZ27_02895 ENOG4105C85 amino acid ADZ27_02900 ENOG4105CUY Mechanosensitive ion channel ADZ27_02905 ENOG4108RCM Nitroreductase ADZ27_02910 ENOG4105MSB protein, conserved in bacteria ADZ27_02915 ENOG4105WQ6 Membrane ADZ27_02930 ENOG4107635 Hok Gef family protein ADZ27_02935 ENOG4108SER Transposase ADZ27_02940 ENOG4108TSE Transferase ADZ27_02945 ENOG4107RNH Outer membrane receptor FepA ADZ27_02950 ENOG4105E93 esterase ADZ27_02955 ENOG41085A6 mbth domain-containing protein ADZ27_02960 ENOG4105C0W non-ribosomal peptide synthetase ADZ27_02965 ENOG4108QY5 Ferric enterobactin transport protein ADZ27_02970 ENOG4105E0A ABC, transporter ADZ27_02975 ENOG4105TVJ transport system, permease ADZ27_02980 ENOG4105DQ5 transport system permease protein ADZ27_02990 ENOG4105PEC Iron-enterobactin transporter periplasmic binding protein ADZ27_02995 ENOG4105E4F Isochorismate synthase ADZ27_03000 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase ADZ27_03005 ENOG4105WQI isochorismatase ADZ27_03010 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase ADZ27_03015 ENOG4108TZA Required for optimal enterobactin synthesis. Acts as a proofreading enzyme that prevents EntB misacylation by hydrolyzing the thioester bound existing between EntB and wrongly charged molecules (By similarity) ADZ27_03020 ENOG4105D22 carbon starvation protein ADZ27_03025 ENOG4105VCD cytoplasmic protein ADZ27_03030 ENOG4107SCQ Iron-containing alcohol dehydrogenase ADZ27_03035 ENOG4105CHM Aminotransferase ADZ27_03040 ENOG4105GTN ParB Domain Protein Nuclease ADZ27_03045 ENOG4105BZV Phosphoadenosine phosphosulfate reductase ADZ27_03050 ENOG4105DQS Transcriptional regulator ADZ27_03055 ENOG4108KHN disulfide isomerase, thiol-disulfide oxidase ADZ27_03060 ENOG4105D3R alkyl hydroperoxide reductase ADZ27_03065 ENOG4108JU3 Alkyl hydroperoxide reductase ADZ27_03070 ENOG4108U51 Universal stress protein ADZ27_03075 ENOG4105E2A Dehydrogenase ADZ27_03085 ENOG4105NXH GreA GreB family elongation factor ADZ27_03090 ENOG4105KTS ribonuclease ADZ27_03095 ENOG4107QPK )-transporter ADZ27_03110 ENOG4105CHY citrate lyase, alpha ADZ27_03115 ENOG4105CI0 Citrate lyase ADZ27_03125 ENOG4105DUA (citrate (pro-3S)-lyase ligase ADZ27_03130 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism ADZ27_03135 ENOG4106YYS transcriptional regulatory protein ADZ27_03140 ENOG4105CEE C4-dicarboxylate transporter ADZ27_03145 ENOG41079UR PagP is required both for biosynthesis of hepta-acylated lipid A species containing palmitate and for resistance to cationic antimicrobial peptides (CAMPs). It catalyzes the transfer of a palmitate chain (16 0) from the sn-1 position of a glycerophospholipid to the free hydroxyl group of the (R)-3- hydroxymyristate chain at position 2 of lipid A (endotoxin) (By similarity) ADZ27_03150 ENOG4105VEQ Cold shock protein ADZ27_03165 ENOG410607N Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatE shares overlapping functions with TatA (By similarity) ADZ27_03175 ENOG41064T2 transcriptional regulator, lysR family ADZ27_03195 ENOG4105DZ1 carboxypeptidase ADZ27_03200 ENOG4105K6T rare lipoprotein A ADZ27_03205 ENOG4105CNI cell division protein FtsW ADZ27_03210 ENOG4105CJN penicillin-binding protein ADZ27_03220 ENOG4105KEM Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) ADZ27_03225 ENOG4108TGR phosphatase ADZ27_03235 ENOG4105DJF DNA polymerase III, delta' subunit ADZ27_03250 ENOG4107PAI alpha helical protein ADZ27_03255 ENOG4105EUU Sel1 domain protein repeat-containing protein ADZ27_03260 ENOG41069CF Protein of unknown function (DUF1266) ADZ27_03265 ENOG4105QFC Hsc56 co-chaperone of HscC ADZ27_03270 ENOG4107JFD Sel1 repeat ADZ27_03275 ENOG41069CF Protein of unknown function (DUF1266) ADZ27_03280 ENOG4105QFC Hsc56 co-chaperone of HscC ADZ27_03285 ENOG4105F7F Chaperone ADZ27_03295 ENOG4105CDA abc transporter atp-binding protein ADZ27_03300 ENOG4105DRP amino acid AbC transporter ADZ27_03305 ENOG4105EAD ABC transporter ADZ27_03310 ENOG4107RP9 extracellular solute-binding protein, family 3 ADZ27_03315 ENOG4105F2I Transposase ADZ27_03320 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) ADZ27_03325 ENOG4108JU5 Magnesium and cobalt efflux protein ADZ27_03335 ENOG4105C9A Phoh family ADZ27_03345 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family ADZ27_03385 ENOG4105CAQ asparagine synthetase ADZ27_03390 ENOG4105D4U had-superfamily hydrolase, subfamily iia ADZ27_03395 ENOG4105E2R ROK family ADZ27_03400 ENOG4105CE4 GlcNAc 6-P deacetylase ADZ27_03410 ENOG4105CI1 PTS System ADZ27_03425 ENOG4105GX6 (LipO)protein ADZ27_03430 ENOG41090R7 Ferric uptake ADZ27_03445 ENOG4105MHQ Low-potential electron donor to a number of redox enzymes (By similarity) ADZ27_03450 ENOG4105NNH LexA regulated protein ADZ27_03455 ENOG4105EV9 Alpha Beta Hydrolase ADZ27_03460 ENOG4107CDU Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated (By similarity) ADZ27_03465 ENOG4107QIX Phosphoglucomutase (EC 5.4.2.2 ADZ27_03485 ENOG4105D5Q Arginine ornithine antiporter ADZ27_03490 ENOG4105CXN decarboxylase ADZ27_03500 ENOG4105EEX Two component transcriptional regulator (Winged helix family ADZ27_03505 ENOG4105C08 Histidine kinase ADZ27_03530 ENOG4105XIQ Protein of unknown function (DUF2517) ADZ27_03535 ENOG4105CNA YD repeat protein ADZ27_03540 ENOG41079JQ Membrane ADZ27_03545 ENOG4105CNA YD repeat protein ADZ27_03550 ENOG4106R09 ADZ27_03555 ENOG410600T transposase ADZ27_03560 ENOG410600T transposase ADZ27_03565 ENOG4107SEY Conserved Protein ADZ27_03570 ENOG4105CVP deoxyribo-dipyrimidine photolyase ADZ27_03575 ENOG4105DUX Transporter ADZ27_03580 ENOG4107QNR UPF0135 protein ADZ27_03585 ENOG4105P4J Allophanate hydrolase, subunit 1 ADZ27_03590 ENOG4107R7A Allophanate hydrolase subunit 2 ADZ27_03605 ENOG4108KK1 membrane protein AbrB duplication ADZ27_03610 ENOG4108MY7 Fimbrial ADZ27_03615 ENOG4108TTM chaperone ADZ27_03620 ENOG4106PG1 outer membrane usher protein ADZ27_03625 ENOG4106UBK fimbrial-like adhesin protein ADZ27_03630 ENOG4105BZN citrate synthase ADZ27_03640 ENOG4108UTY succinate dehydrogenase, cytochrome b556 subunit ADZ27_03645 ENOG4105N1I succinate dehydrogenase, hydrophobic membrane anchor protein ADZ27_03650 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) ADZ27_03655 ENOG4105E33 succinate dehydrogenase ADZ27_03665 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 ADZ27_03670 ENOG4105C7S Dehydrogenase ADZ27_03680 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha ADZ27_03685 ENOG4105FDP GntR family transcriptional regulator ADZ27_03690 ENOG4105DM4 PTS System ADZ27_03695 ENOG4105C8I hydrolase, family 38 ADZ27_03705 ENOG4105C4M (Ubiquinol oxidase) subunit I ADZ27_03710 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii ADZ27_03720 ENOG4105KJB cyd operon protein YbgE ADZ27_03725 ENOG4107YD3 Thioesterase ADZ27_03730 ENOG4105E02 MotA TolQ exbB proton channel ADZ27_03735 ENOG4105M8F Biopolymer transport protein exbD tolR ADZ27_03740 ENOG4108Z82 Cell envelope integrity inner membrane protein TolA ADZ27_03750 ENOG4105KCK Peptidoglycan-associated lipoprotein ADZ27_03755 ENOG4105UFD tol-pal system protein YbgF ADZ27_03800 ENOG4106Z1T Nicotinamide Mononucleotide Transporter ADZ27_03805 ENOG4105PGM cation diffusion facilitator family transporter ADZ27_03810 ENOG4105JND homeobox protein ADZ27_03820 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) ADZ27_03830 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) ADZ27_03840 ENOG4105F0Z galactose-1-phosphate uridylyltransferase ADZ27_03845 ENOG4105CMR udp-glucose 4-epimerase ADZ27_03850 ENOG4105DKW ABC transporter ADZ27_03855 ENOG4105F4R Transcriptional regulator mode ADZ27_03860 ENOG410680R Protein of unknown function (DUF2592) ADZ27_03865 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein ADZ27_03870 ENOG4105E0C molybdate abc transporter ADZ27_03875 ENOG4105CGB Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system (By similarity) ADZ27_03880 ENOG4108K4B hydrolase ADZ27_03890 ENOG4105F04 LysR family Transcriptional regulator ADZ27_03895 ENOG4105C7F AcnD-accessory protein PrpF ADZ27_03900 ENOG4107QPK )-transporter ADZ27_03905 ENOG4107QM5 aconitate hydratase ADZ27_03910 ENOG4105NBR Pectinesterase ADZ27_03915 ENOG4108V1U phospholipid-binding protein ADZ27_03920 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) ADZ27_03930 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) ADZ27_03935 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) ADZ27_03940 ENOG4105E78 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) ADZ27_03950 ENOG4105CHW UPF0052 protein ADZ27_03965 ENOG4108RIR Molybdenum cofactor biosynthesis protein ADZ27_03975 ENOG4105M00 molybdopterin converting factor, subunit 1 ADZ27_03980 ENOG4108ZAF Molybdopterin ADZ27_03985 ENOG4105HFZ Membrane ADZ27_03990 ENOG410733J conserved inner membrane protein ADZ27_03995 ENOG4107UXM Membrane ADZ27_04000 ENOG4105DZQ phospholipase D Transphosphatidylase ADZ27_04005 ENOG4105X23 Endonuclease Exonuclease phosphatase ADZ27_04010 ENOG4105I9U inner membrane protein ybhQ ADZ27_04015 ENOG4107QWP ABC-2 type transporter ADZ27_04020 ENOG4107QWP ABC-2 type transporter ADZ27_04025 ENOG4105CJ1 ABC, transporter ADZ27_04035 ENOG4107MVR Transcriptional regulator ADZ27_04040 ENOG4105C1J atp-dependent rna helicase ADZ27_04045 ENOG4108UV1 cellular component movement ADZ27_04050 ENOG4105DVT helicase ADZ27_04055 ENOG4108MTB glycosyl transferase family ADZ27_04060 ENOG4105DG4 malate L-lactate dehydrogenase ADZ27_04065 ENOG4105VR4 UPF0379 protein ybiJ ADZ27_04070 ENOG4105KSC Transcriptional regulator, TraR DksA family ADZ27_04080 ENOG4108IU3 tonb-dependent siderophore receptor ADZ27_04085 ENOG4105ZY9 UPF0379 protein ybiM ADZ27_04095 ENOG4105D8X mechanosensitive ion channel ADZ27_04100 ENOG4105CDA abc transporter atp-binding protein ADZ27_04105 ENOG4105E5Q amino acid AbC transporter ADZ27_04110 ENOG4107R0W ABC transporter ADZ27_04125 ENOG4107AQZ Membrane ADZ27_04130 ENOG4108T1M outer membrane protein x ADZ27_04135 ENOG4108I6E Sulfatase ADZ27_04145 ENOG4105KST dependent repressor ADZ27_04150 ENOG4105F4P )-transporter ADZ27_04155 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein ADZ27_04160 ENOG4105C5H ABC transporter ADZ27_04165 ENOG41072TH Protein of unknown function (DUF1479) ADZ27_04170 ENOG4108HCJ Hydrolase ADZ27_04175 ENOG4105C6N Formate acetyltransferase ADZ27_04180 ENOG4105F1A Pyruvate formate-lyase ADZ27_04185 ENOG4107T9Z Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) ADZ27_04190 ENOG4105D06 uba thif-type nad fad binding protein ADZ27_04195 ENOG4105CVM Molybdenum cofactor synthesis domain protein ADZ27_04200 ENOG4105D44 asparaginase ADZ27_04205 ENOG4108JQ6 ABC transporter ADZ27_04210 ENOG4105DEF Extracellular solute-binding protein, family 5 ADZ27_04220 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component ADZ27_04225 ENOG4105BZU Histidine kinase ADZ27_04230 ENOG41064RH membrane protein YliF ADZ27_04240 ENOG4105UFT Represses biofilm formation in M9C glu and LB glu media but not in M9C and LB media. Seems to act as a global regulator of several genes involved in catabolite repression and stress response and regulation of the uptake and export of signaling pathways. Could be involved the regulation of indole as well as uptake and export of AI-2 through a cAMP-dependent pathway ADZ27_04245 ENOG4105D8V Glucose sorbosone dehydrogenase ADZ27_04250 ENOG4108TGY Glutathione S-transferase ADZ27_04255 ENOG4105DZ1 carboxypeptidase ADZ27_04260 ENOG4107FB0 transcriptional regulator DeoR family ADZ27_04265 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase ADZ27_04270 ENOG4107QF7 multi-drug ADZ27_04280 ENOG4108HCJ Hydrolase ADZ27_04285 ENOG4106UW1 Major Facilitator superfamily ADZ27_04290 ENOG4108RFG Tetr family transcriptional regulator ADZ27_04300 ENOG4105GWF inner membrane protein YbjM ADZ27_04305 ENOG41090BQ Glutaredoxin ADZ27_04310 ENOG4105X20 member of the soxRS regulon which mediates in part the increased levels of superoxide in response to oxidative stress ADZ27_04315 ENOG4108DBC nitroreductase ADZ27_04325 ENOG4108RMJ sensory transduction regulator ADZ27_04335 ENOG4107RUE extracellular solute-binding protein family 1 ADZ27_04340 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) ADZ27_04345 ENOG4105F38 ABC transporter, permease ADZ27_04350 ENOG4105D38 putrescine abc transporter ADZ27_04355 ENOG4105RBQ inner membrane protein ybjO ADZ27_04365 ENOG4106TNF Periplasmic binding protein ADZ27_04370 ENOG4105DMR ABC, transporter ADZ27_04375 ENOG4105GBT ABC transporter ADZ27_04380 ENOG4106PMH Extracellular solute-binding protein family 3 ADZ27_04385 ENOG4105E5Z arginine transporter ATP-binding subunit ADZ27_04390 ENOG41064MM (LipO)protein ADZ27_04400 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase ADZ27_04405 ENOG4107VBM 3-beta hydroxysteroid dehydrogenase isomerase ADZ27_04410 ENOG4105CGD Nad-dependent epimerase dehydratase ADZ27_04415 ENOG4105C5W Aldolase ADZ27_04420 ENOG4105C7K acetolactate synthase ADZ27_04425 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) ADZ27_04435 ENOG4105DWU Membrane ADZ27_04440 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) ADZ27_04450 ENOG4105CPB ATP-dependent endonuclease of the OLD family ADZ27_04455 ENOG4108MJ5 VirK protein ADZ27_04460 ENOG4105DJY efflux transporter, rnd family, mfp subunit ADZ27_04465 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) ADZ27_04470 ENOG4105VEQ Cold shock protein ADZ27_04480 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit ADZ27_04490 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) ADZ27_04500 ENOG4108JJ8 (ABC) transporter ADZ27_04505 ENOG4108JJ9 ABC, transporter ADZ27_04510 ENOG4105C3M thioredoxin reductase ADZ27_04515 ENOG4105EW9 transcriptional regulator AsnC family ADZ27_04520 ENOG4105CNU cell division protein FtsK ADZ27_04530 ENOG4105D1H recombination factor protein RarA ADZ27_04540 ENOG4107QY8 reductase ADZ27_04545 ENOG4105QAX Iron-sulfur ADZ27_04550 ENOG4107KGK dmso reductase anchor subunit ADZ27_04555 ENOG4105CHJ isochorismatase hydrolase ADZ27_04565 ENOG4105E5D amino acid ADZ27_04570 ENOG410642W LysR family Transcriptional regulator ADZ27_04575 ENOG4108X0B nad(p)h dehydrogenase (quinone) ADZ27_04580 ENOG4105F1A Pyruvate formate-lyase ADZ27_04585 ENOG4105C6N Formate acetyltransferase ADZ27_04590 ENOG4105TMB Formate nitrite transporter ADZ27_04595 ENOG4105DDY UPF0142 protein ycaO ADZ27_04600 ENOG4107VMU Membrane ADZ27_04615 ENOG4108K0D peptidase, M48 ADZ27_04625 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) ADZ27_04635 ENOG4108EQH DNA internalization-related competence protein ComEC Rec2 ADZ27_04640 ENOG4105BZ1 (ABC) transporter ADZ27_04645 ENOG4105CHD Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity) ADZ27_04650 ENOG4105T0Z Conserved Protein ADZ27_04665 ENOG4107VR7 transferase activity, transferring phosphorus-containing groups ADZ27_04670 ENOG4107S90 membrAne ADZ27_04675 ENOG4106371 Methyltransferase ADZ27_04685 ENOG4105DAH Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF (By similarity) ADZ27_04695 ENOG4105DIT ErfK YbiS YcfS YnhG family protein ADZ27_04700 ENOG4105EAQ (twin-arginine translocation) pathway signal ADZ27_04705 ENOG4105C5X domain protein ADZ27_04710 ENOG4105CGF Aromatic amino acid aminotransferase ADZ27_04720 ENOG4105FCK Membrane ADZ27_04735 ENOG4105CD8 aminopeptidase N ADZ27_04740 ENOG4105E2Y ABC, transporter ADZ27_04745 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component ADZ27_04755 ENOG4105GVF (ABC) transporter ADZ27_04760 ENOG4108UZX fmn reductase ADZ27_04765 ENOG41071VI Part of the elfADCG-ycbUVF fimbrial operon, which promotes adhesion of bacteria to different abiotic surfaces. ElfA is the major fimbrial subunit produced by this operon ADZ27_04770 ENOG4106JJN Part of the elfADCG-ycbUVF fimbrial operon, which promotes adhesion of bacteria to different abiotic surfaces. Could be required for the biogenesis of the ElfA fimbriae ADZ27_04775 ENOG4105CW0 outer membrane usher protein ADZ27_04780 ENOG4108MDY Fimbrial ADZ27_04785 ENOG4105Q7J Fimbrial ADZ27_04790 ENOG4105MX3 Fimbrial ADZ27_04795 ENOG4106PH7 chaperone ADZ27_04805 ENOG4108T7E Contributes to the efficiency of the cell division process by stabilizing the polymeric form of the cell division protein FtsZ. Acts by promoting interactions between FtsZ protofilaments and suppressing the GTPase activity of FtsZ (By similarity) ADZ27_04810 ENOG4105QVC MOSC domain-containing protein ADZ27_04815 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) ADZ27_04820 ENOG4105C5H ABC transporter ADZ27_04825 ENOG4105F1S paraquat-inducible protein a ADZ27_04830 ENOG4105DY2 Paraquat-inducible protein b ADZ27_04835 ENOG4108Q2G (LipO)protein ADZ27_04840 ENOG4105WFT During stationary phase, converts 70S ribosomes to an inactive dimeric form (100S ribosomes) (By similarity) ADZ27_04850 ENOG4105DAN ATP-dependent protease ADZ27_04860 ENOG4105UYK outer membrane protein a ADZ27_04875 ENOG4108RZ1 DNA transformation protein ADZ27_04880 ENOG4105EM2 membrane ADZ27_04885 ENOG410901E Membrane ADZ27_04890 ENOG41088T4 Helicase IV ADZ27_04905 ENOG4108ZQS transposase ADZ27_04925 ENOG4105K4P CoA-binding domain protein ADZ27_04940 ENOG4105VSY K01512 acylphosphatase EC 3.6.1.7 ADZ27_04945 ENOG4108Z0T Part of a sulfur-relay system (By similarity) ADZ27_04950 ENOG4108MN8 Membrane ADZ27_04960 ENOG4105E3S small subunit ADZ27_04965 ENOG4105DPX Hydrogenase, large subunit ADZ27_04970 ENOG4105X7T Ni Fe-hydrogenase, b-type cytochrome subunit ADZ27_04975 ENOG4108USZ hydrogenase ADZ27_04980 ENOG4108VXY Hydrogenase-1 operon protein HyaE ADZ27_04985 ENOG4105MVP hydrogenase-1 operon protein HyaF ADZ27_04990 ENOG4105C4M (Ubiquinol oxidase) subunit I ADZ27_04995 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii ADZ27_05005 ENOG4105D6F Phosphatase ADZ27_05010 ENOG4105D75 Capsular exopolysaccharide family ADZ27_05015 ENOG4107ZF2 Phosphatase ADZ27_05020 ENOG4105DAY polysaccharide export protein ADZ27_05025 ENOG4105E3R (LipO)protein ADZ27_05030 ENOG4108W78 Pfam:DUF1017 ADZ27_05035 ENOG4108Y9B (LipO)protein ADZ27_05055 ENOG41060EU Cold shock-like protein ADZ27_05060 ENOG4105VEQ Cold shock protein ADZ27_05070 ENOG4106H71 Overexpression increases levels of unsaturated fatty acids and suppresses both the temperature-sensitive fabA6 mutation and cold-sensitive secG null mutation ADZ27_05075 ENOG4105HEE Binding Domain protein ADZ27_05080 ENOG4105BZU Histidine kinase ADZ27_05085 ENOG4108SV3 Tmao reductase system periplasmic protein tort ADZ27_05090 ENOG4106WF9 DNA-binding transcriptional regulator TorR ADZ27_05095 ENOG4105CUW cytochrome C-TYPE protein ADZ27_05100 ENOG4107QY8 reductase ADZ27_05105 ENOG4108SBI Involved in the biogenesis of TorA. Acts on TorA before the insertion of the molybdenum cofactor and, as a result, probably favors a conformation of the apoenzyme that is competent for acquiring the cofactor (By similarity) ADZ27_05125 ENOG4105D6F Phosphatase ADZ27_05130 ENOG4105XH3 ADZ27_05145 ENOG4105XF5 Escherichia coli IMT2125 genomic chromosome, IMT2125 ADZ27_05150 ENOG4105C2W permease ADZ27_05165 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) ADZ27_05185 ENOG4108R86 Transcriptional regulator ADZ27_05190 ENOG4105C26 Dehydrogenase ADZ27_05200 ENOG4105CK7 Sodium proline symporter ADZ27_05215 ENOG410650H (LipO)protein ADZ27_05220 ENOG4105DBE peroxidase ADZ27_05230 ENOG4105D5M phosphate starvation-inducible protein ADZ27_05235 ENOG4106FQ9 Biofilm PGA synthesis protein PgaD ADZ27_05240 ENOG4105CND Glycosyl transferase, family 2 ADZ27_05245 ENOG4107BJW polysaccharide deacetylase ADZ27_05255 ENOG4105F2I Transposase ADZ27_05265 ENOG4108UVJ appr-1-p processing domain protein ADZ27_05270 ENOG4107RZC phospholipase d ADZ27_05295 ENOG4105C3A Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs) (By similarity) ADZ27_05300 ENOG4105NAC (LipO)protein ADZ27_05305 ENOG4108W47 Acidic protein msyB ADZ27_05320 ENOG4105D1S lipid A biosynthesis ADZ27_05330 ENOG4108YYC ycei family ADZ27_05335 ENOG4105DS1 cytochrome b561 ADZ27_05340 ENOG4106974 biofilm formation ADZ27_05350 ENOG4105PVA Biofilm formation regulatory protein BssS ADZ27_05355 ENOG4105MEA DNA damage-inducible protein i ADZ27_05365 ENOG4105F3T (LipO)protein ADZ27_05370 ENOG4105E9S glutaredoxin 2 ADZ27_05380 ENOG4105D9U N-acetyltransferase ADZ27_05390 ENOG4105EP9 oxidoreductase ADZ27_05395 ENOG4105CJR Integral membrane protein (MviN ADZ27_05400 ENOG4105QVD Flagella synthesis protein FlgN ADZ27_05405 ENOG4105M9M anti-sigma28 factor FlgM ADZ27_05410 ENOG4105CKS Flagella basal body P-ring formation protein flgA ADZ27_05415 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) ADZ27_05420 ENOG4108ZC9 flagellar basal-body rod protein flgc ADZ27_05425 ENOG4105W00 Flagellar hook capping protein ADZ27_05430 ENOG4105BZE flagellar hook protein, FlgE ADZ27_05435 ENOG4108KPB Flagellar basal-body rod protein FlgF ADZ27_05440 ENOG4105CGA flagellar basal-body rod protein FlgG ADZ27_05455 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj ADZ27_05460 ENOG4105E1Q flagellar hook-associated protein ADZ27_05465 ENOG4105DTJ flagellar hook-associated protein ADZ27_05470 ENOG4107QQB Ribonuclease E ADZ27_05475 ENOG41071G1 Uncharacterized protein YceQ ADZ27_05480 ENOG4105EI2 Pseudouridine synthase ADZ27_05485 ENOG4108UHJ MAF-like protein ADZ27_05490 ENOG4105FCQ metal-binding, possibly nucleic acid-binding protein ADZ27_05510 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase ADZ27_05515 ENOG4105CHR reductase ADZ27_05520 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) ADZ27_05525 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) ADZ27_05530 ENOG4105YAZ 4-amino-4-deoxychorismate lyase ADZ27_05535 ENOG4105HHA aminodeoxychorismate lyase ADZ27_05545 ENOG4107QRG dna polymerase iii ADZ27_05550 ENOG4105F8V Hydrolase, tatD family ADZ27_05555 ENOG4105CI1 PTS System ADZ27_05560 ENOG4105CNM Receptor ADZ27_05565 ENOG4105K59 histidine triad (HIT) protein ADZ27_05570 ENOG41090DQ Lipoprotein ADZ27_05575 ENOG4108WEF Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b) (By similarity) ADZ27_05595 ENOG4105CEP NADH dehydrogenase ADZ27_05600 ENOG4107MBR 17 kDa surface antigen ADZ27_05605 ENOG4108IND Tetr family transcriptional regulator ADZ27_05610 ENOG4105RC8 Reduces the permeability of the outer membrane to copper. Seems to be involved in the regulation of biofilm formation. May decrease biofilm formation by repressing cell-cell interaction and cell surface interaction ADZ27_05615 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein ADZ27_05620 ENOG4108JA2 transcriptioN-repair coupling factor ADZ27_05625 ENOG4105IQC Inner membrane protein YcfT ADZ27_05630 ENOG4105D60 lipoprotein releasing system transmembrane protein ADZ27_05635 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) ADZ27_05640 ENOG4105D60 lipoprotein releasing system transmembrane protein ADZ27_05650 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) ADZ27_05665 ENOG4107RUE extracellular solute-binding protein family 1 ADZ27_05670 ENOG4105D38 putrescine abc transporter ADZ27_05675 ENOG4105F38 ABC transporter, permease ADZ27_05680 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) ADZ27_05695 ENOG4105EZE Cupin 4 family protein ADZ27_05700 ENOG4105IFJ Histidine kinase ADZ27_05705 ENOG4105XJC Two component transcriptional regulator (Winged helix family ADZ27_05710 ENOG4107QTF adenylosuccinate lyase ADZ27_05730 ENOG4108R99 pseudouridine synthase ADZ27_05735 ENOG4108HMX isocitrate dehydrogenase (NADP) ADZ27_05740 ENOG4106JA9 ADZ27_05745 ENOG4106J3D ADZ27_05750 ENOG4106VW7 Interacts with a short DNA sequence about one-quarter of the way into the major capsid protein gene 23 of T4, and the inhibition occurs when this late gene of the virus is expressed ADZ27_05755 ENOG41090WB Transposase is3 is911 ADZ27_05770 ENOG4105QYW Excisionase-like protein from lambdoid prophage 14 ADZ27_05775 ENOG4107712 ADZ27_05780 ENOG4105RDA repressor ADZ27_05785 ENOG41078CG DNA-binding transcriptional regulator ADZ27_05790 ENOG4108S1U ADZ27_05800 ENOG4105CAR Terminase, large subunit ADZ27_05810 ENOG4105EFC phage portal protein HK97 family ADZ27_05815 ENOG4108T86 baseplate J family protein ADZ27_05820 ENOG4105Y0G tail protein ADZ27_05825 ENOG4105Y9F tail fiber protein ADZ27_05835 ENOG4108US3 tail fiber assembly ADZ27_05845 ENOG4108C33 Resolvase ADZ27_05850 ENOG4108R4U Hnh endonuclease ADZ27_05865 ENOG41064WM Uncharacterized protein YcgX ADZ27_05870 ENOG4108XDN Transcriptional regulator ADZ27_05875 ENOG4105BZU Histidine kinase ADZ27_05880 ENOG4105WKE Probably a connector protein for RcsB C regulation of biofilm formation, providing additional signal input into the two- component signaling pathway. Partially antagonizes the activities of YmgA and AriR, proteins that, via the Rcs phosphorelay, promote the synthesis of colanic acid, an exopolysaccharide and matrix component ADZ27_05885 ENOG41077SS Probably a connector protein for RcsB C regulation of biofilm formation, providing additional signal input into the two- component signaling pathway. May serve to stimulate biofilm maturation, probably via the Rcs phosphorelay. Mild overexpression at 16 degrees Celsius increases the production of colanic acid, an exopolysaccharide and matrix component, and reduces adhesive curli fimbriae expression. Both of these effects require RcsB ADZ27_05895 ENOG410738I uncharacterized protein ymgC ADZ27_05900 ENOG4105BZU Histidine kinase ADZ27_05925 ENOG410658X ADZ27_05950 ENOG4107QMS site-determining protein ADZ27_05960 ENOG4105S66 prophage protein ADZ27_05965 ENOG41066UD Inhibits activity of g-type lysozyme, which confers increased lysozyme tolerance to the bacterium ADZ27_05980 ENOG4105FBJ fumarylacetoacetate (faa) hydrolase ADZ27_05990 ENOG4106PXS Toxin, which has some hemolytic activity towards mammalian cells. Acts by forming a pore-like structure upon contact with mammalian cells ADZ27_05995 ENOG4105KT5 UmuD protein ADZ27_06000 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) ADZ27_06005 ENOG410635M Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein (By similarity) ADZ27_06020 ENOG4105ED1 spovr family ADZ27_06030 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) ADZ27_06040 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A ADZ27_06050 ENOG4108T7K Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Increasing levels of c-di-GMP lead to decreased motility (By similarity) ADZ27_06055 ENOG4105Y3U Transglycosylase-associated protein ADZ27_06070 ENOG4105VDH Dihydroxyacetone kinase ADZ27_06075 ENOG4108UTZ Dihydroxyacetone kinase ADZ27_06080 ENOG4105CMT Dihydroxyacetone kinase ADZ27_06085 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family ADZ27_06090 ENOG4105I1J Autotransporter ADZ27_06100 ENOG4105C3G gtp-binding protein ADZ27_06110 ENOG4105MGX transcription activated by CRP (cyclic AMP receptor protein), a global transcription factor involved in regulation of metabolism in enteric bacteria ADZ27_06115 ENOG4105CHH sulfate transporter ADZ27_06120 ENOG4105C5T Phosphoribosyl pyrophosphate synthase ADZ27_06125 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) ADZ27_06135 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) ADZ27_06145 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) ADZ27_06150 ENOG4108YY7 Invasion gene expression up-regulator SirB ADZ27_06155 ENOG41063JG Transcriptional regulator ADZ27_06180 ENOG4105EWV Sodium calcium exchanger membrane region ADZ27_06185 ENOG4105WS7 Cation transport regulator ADZ27_06190 ENOG4108NH8 Cation transport protein ADZ27_06195 ENOG41090EX DsrE family ADZ27_06200 ENOG4105ID0 Putative invasin ADZ27_06205 ENOG4105WH1 Two component transcriptional regulator luxr family ADZ27_06210 ENOG4105BZU Histidine kinase ADZ27_06220 ENOG4105DQQ Major facilitator superfamily MFS_1 ADZ27_06230 ENOG4108IUE nitrate reductase beta subunit ADZ27_06235 ENOG4105R3A Nitrate reductase ADZ27_06240 ENOG41076YT nitrate reductase, gamma subunit ADZ27_06260 ENOG4105CIY formyltetrahydrofolate deformylase ADZ27_06270 ENOG4105D78 K07001 NTE family protein ADZ27_06280 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase ADZ27_06285 ENOG4108SAU DNA-binding protein H-ns ADZ27_06290 ENOG4107104 thymidine kinase ADZ27_06305 ENOG4108EKI Dehydrogenase ADZ27_06310 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein ADZ27_06315 ENOG4105F2I Transposase ADZ27_06320 ENOG4108J59 Extracellular solute-binding protein, family 5 ADZ27_06325 ENOG4108ZQS transposase ADZ27_06335 ENOG4108J59 Extracellular solute-binding protein, family 5 ADZ27_06345 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component ADZ27_06350 ENOG4105C3U ABC transporter ADZ27_06355 ENOG4108JQ7 (ABC) transporter ADZ27_06375 ENOG4107SVH Potassium channel protein ADZ27_06380 ENOG4105K9H YciI-like protein ADZ27_06385 ENOG410822N TonB family ADZ27_06390 ENOG4105NAU thioesterase Superfamily protein ADZ27_06405 ENOG4105EIF outer membrane protein W ADZ27_06410 ENOG4108N8X transition metal ion binding ADZ27_06415 ENOG4108Z9Z response to DNA damage stimulus ADZ27_06435 ENOG4105DK0 Indole-3-glycerol phosphate synthase ADZ27_06440 ENOG4108EFP Anthranilate synthase component II ADZ27_06445 ENOG4105CRQ synthase (Component I) ADZ27_06450 ENOG4105DB7 PHP domain protein ADZ27_06455 ENOG4107RTD sua5 ycio yrdc ywlc family protein ADZ27_06460 ENOG4105EG3 transmembrane signal peptide protein ADZ27_06465 ENOG4105FE9 pseudouridine synthase ADZ27_06470 ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase ADZ27_06475 ENOG4105UBK short-chain dehydrogenase reductase ADZ27_06485 ENOG4105ERU peptidase ADZ27_06490 ENOG4105RKX Protein of unknown function (DUF2498) ADZ27_06500 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) ADZ27_06505 ENOG4107R11 Transcriptional regulator ADZ27_06525 ENOG4107QM5 aconitate hydratase ADZ27_06535 ENOG4105EYK Phosphatidylglycerophosphatase B ADZ27_06540 ENOG4105Q4A inner membrane protein yciS ADZ27_06545 ENOG4105CFV Tetratricopeptide repeat protein ADZ27_06555 ENOG4108ZJT translation initiation factor, Sui1 ADZ27_06560 ENOG41061RM osmotically inducible lipoprotein ADZ27_06565 ENOG4105N2W Transcriptional regulator ADZ27_06575 ENOG4105BZU Histidine kinase ADZ27_06590 ENOG4105Q4T oxidoreductase ADZ27_06595 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH ADZ27_06600 ENOG4105WDY DNA (cytosine-5-)-methyltransferase ADZ27_06605 ENOG4108JQ2 peptide transport system atp-binding protein ADZ27_06610 ENOG4108JQ3 Peptide ABC transporter ATP-binding protein ADZ27_06615 ENOG4108EU3 peptide transport system, permease ADZ27_06620 ENOG4108I5W peptide transport system, permease protein ADZ27_06625 ENOG4108HIY periplasmic ADZ27_06635 ENOG4105N0E Protein of unknown function (DUF2543) ADZ27_06640 ENOG4105CUB amino acid ADZ27_06645 ENOG4105CFQ glutamine synthetase ADZ27_06650 ENOG4108Z86 Glutamine amidotransferase ADZ27_06655 ENOG4107VRI Transcriptional regulator ADZ27_06660 ENOG4105C26 Dehydrogenase ADZ27_06665 ENOG4105CJP fad dependent oxidoreductase ADZ27_06670 ENOG4108JPW Aminotransferase ADZ27_06675 ENOG4105E51 psp operon transcriptional activator ADZ27_06680 ENOG41087YS Phage shock protein A ADZ27_06685 ENOG4105YYT phage shock protein B ADZ27_06690 ENOG4105FM1 phage shock protein C ADZ27_06695 ENOG4105NNG Peripheral inner membrane phage-shock protein ADZ27_06700 ENOG4105K8Z Phage shock protein ADZ27_06705 ENOG4107QW3 Sucrose phosphorylase ADZ27_06710 ENOG4105WEM extracellular solute-binding protein ADZ27_06715 ENOG4105HS6 binding-protein-dependent transport systems inner membrane Component ADZ27_06720 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component ADZ27_06725 ENOG4107RRD Dehydrogenase ADZ27_06730 ENOG4107TYA transient receptor potential locus ADZ27_06735 ENOG4105CK5 oxidoreductase ADZ27_06740 ENOG4105C71 hydrolase family 65, central catalytic ADZ27_06745 ENOG4107URF beta-phospho-glucomutase ADZ27_06755 ENOG4107EFV Outer membrane protein G ADZ27_06760 ENOG4105FKQ transcriptional regulator ADZ27_06765 ENOG4105CM6 amino acid regulated cytosolic protein ADZ27_06775 ENOG4108JU8 Transcriptional regulator ADZ27_06780 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) ADZ27_06785 ENOG4107S8C mandelate racemase muconate lactonizing ADZ27_06790 ENOG4105KXI murein peptide amidase A ADZ27_06800 ENOG4105ENX hydrolase ADZ27_06805 ENOG4105EQ2 LysR family Transcriptional regulator ADZ27_06815 ENOG4107QSI ABC, transporter ADZ27_06820 ENOG4105D64 Mechanosensitive ion channel ADZ27_06825 ENOG4105F2I Transposase ADZ27_06830 ENOG4105S5I Membrane ADZ27_06835 ENOG4105Q9Y Universal stress protein ADZ27_06840 ENOG4105DS0 Transcriptional regulator, Crp Fnr family ADZ27_06845 ENOG4105F2I Transposase ADZ27_06850 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) ADZ27_06855 ENOG4105CFC Transporter ADZ27_06865 ENOG4105CH2 amidohydrolase ADZ27_06870 ENOG4106KR7 LysR family Transcriptional regulator ADZ27_06880 ENOG4108DG9 Smr protein MutS2 ADZ27_06885 ENOG4105BZU Histidine kinase ADZ27_06900 ENOG4105C1J atp-dependent rna helicase ADZ27_06910 ENOG4107R08 Integrase ADZ27_06915 ENOG4107160 Rac prophage ADZ27_06920 ENOG41070YT Rac prophage ADZ27_06925 ENOG4106YAH restriction alleviation and modification enhancement ADZ27_06930 ENOG4108PNI recT protein ADZ27_06935 ENOG41076J9 exonuclease VIII ADZ27_06945 ENOG4107C82 Rac prophage ADZ27_06960 ENOG410649Z repressor ADZ27_06965 ENOG4105W7J DNA binding ADZ27_06975 ENOG4105ZTP Protein of unknown function (DUF1376) ADZ27_06980 ENOG4105JBR DNA replication protein ADZ27_06990 ENOG4105SZK Rz endopeptidase from lambdoid prophage DLP12 ADZ27_06995 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) ADZ27_07000 ENOG4108ES9 ParB domain protein nuclease ADZ27_07025 ENOG4105F2I Transposase ADZ27_07045 ENOG4108X9F tail fiber protein ADZ27_07050 ENOG4105UZW Tail fiber assembly protein ADZ27_07055 ENOG4105MN3 Resolvase ADZ27_07060 ENOG4105W3V DNA-binding, transcriptional regulator ADZ27_07065 ENOG4108RW8 Universal stress protein F ADZ27_07070 ENOG4105FCK Membrane ADZ27_07075 ENOG4105D95 Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity) ADZ27_07085 ENOG41090X5 Heat shock protein hslJ ADZ27_07090 ENOG4105C5I Dehydrogenase ADZ27_07095 ENOG4107H52 Dicarboxylate transport ADZ27_07100 ENOG410689M (LipO)protein ADZ27_07105 ENOG4105WXT Conserved Protein ADZ27_07110 ENOG4108WFR AraC Family Transcriptional Regulator ADZ27_07115 ENOG4105C26 Dehydrogenase ADZ27_07120 ENOG4105F11 amine oxidase ADZ27_07125 ENOG4105DXM phenylacetic acid degradation protein ADZ27_07130 ENOG4105CRS phenylacetate-CoA oxygenase PaaG subunit ADZ27_07135 ENOG4105N76 Phenylacetate-CoA oxygenase, subunit ADZ27_07140 ENOG4105D9S phenylacetate-CoA oxygenase PaaI subunit ADZ27_07145 ENOG4108ZA2 phenylacetate-CoA oxygenase PaaJ subunit ADZ27_07150 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) ADZ27_07155 ENOG4105E39 Enoyl-CoA hydratase ADZ27_07160 ENOG4108UKI Enoyl-CoA hydratase ADZ27_07165 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase ADZ27_07170 ENOG4108ZJI phenylacetic acid degradation protein ADZ27_07175 ENOG4105CHU acetyl-coa acetyltransferase ADZ27_07180 ENOG4105DZS Phenylacetate-CoA ligase ADZ27_07185 ENOG4105V9J phenylacetic acid degradation operon negative regulatory protein ADZ27_07190 ENOG4108Z0R Transferase ADZ27_07200 ENOG4108MVM Transposase ADZ27_07205 ENOG4108ZQS transposase ADZ27_07210 ENOG4105F9F transposase ADZ27_07215 ENOG4107EF2 surface-exposed virulence protein ADZ27_07220 ENOG4107S5I aldo keto reductase ADZ27_07230 ENOG4108UMZ Cdp-alcohol phosphatidyltransferase ADZ27_07235 ENOG4108HPI phosphatidate Cytidylyltransferase ADZ27_07240 ENOG4105E8V Alpha Beta Hydrolase Fold protein ADZ27_07245 ENOG41077RS Phosphatase ADZ27_07255 ENOG4105CQ7 ATP-dependent helicase ADZ27_07260 ENOG4107DB1 DUF218 domain ADZ27_07265 ENOG4105C26 Dehydrogenase ADZ27_07270 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase ADZ27_07275 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase ADZ27_07280 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase ADZ27_07285 ENOG4105CPW cytochrome b561 ADZ27_07290 ENOG4105UPP uncharacterized protein ydcA ADZ27_07295 ENOG4107NK6 Hok/gef family ADZ27_07300 ENOG4105C8Q Methyl-accepting chemotaxis ADZ27_07305 ENOG4105DDW LysR family Transcriptional regulator ADZ27_07310 ENOG4105E32 cytoplasmic protein ADZ27_07325 ENOG4105Z2P Protein of unknown function (DUF465) ADZ27_07330 ENOG4108Z9I -acetyltransferase ADZ27_07335 ENOG4107WE3 acetyltransferase YdcK ADZ27_07340 ENOG4108NKP c4-dicarboxylate transporter malic acid transport protein ADZ27_07345 ENOG41088CC tellurite resistance protein tehB ADZ27_07350 ENOG4108KKZ (LipO)protein ADZ27_07360 ENOG4108RS6 transposase ADZ27_07365 ENOG4105D7V transposase ADZ27_07370 ENOG4105DKK Benzoate ADZ27_07375 ENOG4108JCI Transcriptional regulator ADZ27_07380 ENOG4105CFP Peptidase U32 ADZ27_07385 ENOG4105RR0 Protein of unknown function (DUF2554) ADZ27_07395 ENOG4105PF0 Antitoxin component of a toxin-antitoxin (TA) module. Functions as an mRNA interferase antitoxin ADZ27_07400 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family ADZ27_07405 ENOG4107TYH extracellular solute-binding protein family 1 ADZ27_07410 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) ADZ27_07415 ENOG4105D81 ABC transporter, permease ADZ27_07420 ENOG4105NRK Binding-protein-dependent transport systems, inner membrane component ADZ27_07435 ENOG410654E Membrane ADZ27_07440 ENOG4105R71 cytoplasmic protein ADZ27_07445 ENOG4108T9Y Inner membrane protein ydcZ ADZ27_07450 ENOG4108Z7F N-acetyltransferase ADZ27_07455 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein ADZ27_07460 ENOG4108WYP Transcriptional regulator ADZ27_07465 ENOG4105CHB tonB-dependent Receptor ADZ27_07470 ENOG4108NS2 receptor ADZ27_07475 ENOG4105C85 amino acid ADZ27_07480 ENOG4108N27 Glutathione S-transferase ADZ27_07490 ENOG4107TV1 YD repeat protein ADZ27_07505 ENOG410600T transposase ADZ27_07515 ENOG4108MEJ flavin reductase domain protein ADZ27_07520 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase ADZ27_07525 ENOG4105JAB phenazine biosynthesis protein, phzf family ADZ27_07530 ENOG4105D0D Nitrate reductase 2, gamma subunit ADZ27_07535 ENOG4108NZN Respiratory nitrate reductase 2 delta chain ADZ27_07540 ENOG4108IUE nitrate reductase beta subunit ADZ27_07545 ENOG4105CRU nitrate reductase, alpha subunit ADZ27_07550 ENOG4107QND Nitrite extrusion protein ADZ27_07565 ENOG4105RPH Inner membrane protein YddG ADZ27_07570 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) ADZ27_07575 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) ADZ27_07580 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein ADZ27_07585 ENOG4108MG3 formate dehydrogenase ADZ27_07590 ENOG41084S7 Plasmid maintenance system antidote protein ADZ27_07595 ENOG4105DQ4 alcohol dehydrogenase ADZ27_07605 ENOG4107AV5 Although this protein associates with the 30S subunit of the ribosome it is not considered to be a bona fide ribosomal protein ADZ27_07610 ENOG4105TPS biofilm-dependent modulation protein ADZ27_07615 ENOG4108Z9K Osmotically inducible protein ADZ27_07620 ENOG4107H6U ABC transporter ADZ27_07625 ENOG4105C3U ABC transporter ADZ27_07630 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component ADZ27_07635 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component ADZ27_07640 ENOG4105DEF Extracellular solute-binding protein, family 5 ADZ27_07645 ENOG4108UQS dipeptidase ADZ27_07650 ENOG4105BZU Histidine kinase ADZ27_07655 ENOG4105BZU Histidine kinase ADZ27_07660 ENOG4105F32 YngK protein ADZ27_07665 ENOG4105E5D amino acid ADZ27_07670 ENOG4105CVK Glutamate decarboxylase ADZ27_07680 ENOG4107RAN Peptidase, M16 ADZ27_07685 ENOG4105PE1 Receptor ADZ27_07690 ENOG4105CQ0 ABC transporter ADZ27_07695 ENOG4105C4X radical SAM domain protein ADZ27_07700 ENOG4105ENH Sulfatase ADZ27_07705 ENOG4105Z68 AraC Family Transcriptional Regulator ADZ27_07715 ENOG4107QKC Oxidoreductase alpha (molybdopterin) subunit ADZ27_07720 ENOG4106PIH fimbrial-like protein ydeQ ADZ27_07725 ENOG4106318 fimbrial-like protein YdeR ADZ27_07730 ENOG4108WDE Fimbrial protein ADZ27_07745 ENOG4105CAF HipA N-terminal domain protein ADZ27_07750 ENOG41061P8 Persistence to inhibition of murein or DNA biosynthesis regulatory protein ADZ27_07765 ENOG4108EMV Catalyzes the phosphorylation of autoinducer 2 (AI-2) to phospho-AI-2, which subsequently inactivates the transcriptional regulator LsrR and leads to the transcription of the lsr operon. Phosphorylates the ring-open form of 4,5-dihydroxy-2,3- pentanedione (DPD), which is the precursor to all AI-2 signaling molecules, at the C5 position (By similarity) ADZ27_07770 ENOG4105DKT Transcriptional regulator ADZ27_07775 ENOG4105C2J ABC transporter ADZ27_07780 ENOG41071MT Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane ADZ27_07785 ENOG4105F5R ABC transporter ADZ27_07790 ENOG4105D4B ABC, transporter ADZ27_07795 ENOG41061GT Aldolase ADZ27_07800 ENOG4105K34 Involved in the degradation of phospho-AI-2, thereby terminating induction of the lsr operon and closing the AI-2 signaling cycle. Catalyzes the cleavage of phosphorylated 4,5- dihydroxy-2,3-pentanedione (P-DPD) to 2-phosphoglycolic acid (PG) and another three-carbon compound ADZ27_07810 ENOG4105FFC UPF0187 protein ADZ27_07820 ENOG4107QZW Altronate oxidoreductase ADZ27_07825 ENOG4105BZU Histidine kinase ADZ27_07830 ENOG4105M0C cytoplasmic protein ADZ27_07835 ENOG4105CSV Glutaminase ADZ27_07840 ENOG4105C26 Dehydrogenase ADZ27_07845 ENOG4105EGI Transcriptional regulator ADZ27_07865 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes ADZ27_07870 ENOG4108XW0 May be a transcriptional activator of genes involved in the multiple antibiotic resistance (Mar) phenotype. It can also activate genes such as sodA, zwf and micF ADZ27_07875 ENOG4106DNR multiple antibiotic resistance protein ADZ27_07880 ENOG4108594 Permease of the drug metabolite transporter ADZ27_07885 ENOG4105E5W Transporter ADZ27_07895 ENOG4105FSR swimming returnes to normal when residues 206-207 are both mutated to Ala. Overexpression also leads to a reduction in flagellar abundance and a 20-fold increase in c-di- GMP levels in vivo. Required for aminoglycoside-mediated induction of biofilm formation, it also plays a lesser role in biofilm production in response to other classes of translation inhibitors. The c-di-GMP produced by this enzyme up-regulates poly-GlcNAc production as well as the biofilm synthesis protein PgaD, although c-di-GMP is probably not the main inducing principle. Cyclic-di- GMP is a second messenger which controls cell surface-associated traits in bacteria ADZ27_07900 ENOG4108YDI single-species biofilm formation on inanimate substrate ADZ27_07905 ENOG4108WTK competence damage-inducible protein ADZ27_07910 ENOG4105DGW oligopeptidase A ADZ27_07915 ENOG4105EMU Dehydrogenase ADZ27_07920 ENOG4107XBN GntR Family Transcriptional Regulator ADZ27_07925 ENOG41061EV selenium-binding protein YdfZ ADZ27_07930 ENOG4105DEI Mannitol dehydrogenase ADZ27_07940 ENOG4105W3V DNA-binding, transcriptional regulator ADZ27_07945 ENOG4105MN3 Resolvase ADZ27_07950 ENOG4105UZW Tail fiber assembly protein ADZ27_07955 ENOG410685N tail fiber protein ADZ27_07960 ENOG4105FKG DNA packaging protein ADZ27_07965 ENOG4106YSC ADZ27_07970 ENOG41064WM Uncharacterized protein YcgX ADZ27_07975 ENOG4106H71 Overexpression increases levels of unsaturated fatty acids and suppresses both the temperature-sensitive fabA6 mutation and cold-sensitive secG null mutation ADZ27_07980 ENOG4106IAW ADZ27_07985 ENOG4105VEQ Cold shock protein ADZ27_07990 ENOG4108YV9 Protein of unknown function (DUF2514) ADZ27_08005 ENOG4105QFS Lysis protein S homolog from lambdoid prophage ADZ27_08010 ENOG4105VEQ Cold shock protein ADZ27_08020 ENOG4105HGD Antitermination protein ADZ27_08025 ENOG4108MXB Protein of unknown function (DUF968) ADZ27_08040 ENOG4105WI6 cell killing protein encoded within cryptic prophage ADZ27_08045 ENOG4105K4U addiction module toxin, RelE StbE family ADZ27_08070 ENOG41087BU transcriptional repressor DicA ADZ27_08095 ENOG4106G8A Qin prophage ADZ27_08110 ENOG4107R08 Integrase ADZ27_08115 ENOG4105CPQ Dehydrogenase ADZ27_08120 ENOG4105CXK mandelate racemase muconate lactonizing ADZ27_08135 ENOG4108MK9 spermidine N(1)-acetyltransferase ADZ27_08145 ENOG4105KBG Protein of unknown function (DUF1161) ADZ27_08150 ENOG4107QY8 reductase ADZ27_08155 ENOG4105C3J Cysteine desulfurase ADZ27_08160 ENOG4105QAX Iron-sulfur ADZ27_08165 ENOG4107KGK dmso reductase anchor subunit ADZ27_08170 ENOG4108NEM leader-binding protein dmsD ADZ27_08180 ENOG4105EWW Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) ADZ27_08185 ENOG4105DAG ROK family ADZ27_08190 ENOG4106NZI LysR family Transcriptional regulator ADZ27_08195 ENOG4105D94 Major Facilitator Superfamily ADZ27_08210 ENOG4105CVW peptidase s1 and s6 chymotrypsin hap ADZ27_08225 ENOG4105DSF transport protein ADZ27_08230 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) ADZ27_08235 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) ADZ27_08240 ENOG4105C5D exported protein ADZ27_08245 ENOG4105D5Q Arginine ornithine antiporter ADZ27_08250 ENOG410642E Short chain dehydrogenase ADZ27_08255 ENOG4105RA2 Membrane ADZ27_08260 ENOG4107EXC regulatoR ADZ27_08265 ENOG4105JJR Histidine kinase ADZ27_08275 ENOG4105C9Q fumarate hydratase class II ADZ27_08280 ENOG4107GFK fumarate ADZ27_08285 ENOG4105EIP mannose-6-phosphate isomerase ADZ27_08290 ENOG4106J39 exported protein ADZ27_08295 ENOG4108QNI outer membrane porin protein ADZ27_08300 ENOG4105CT4 transporter ADZ27_08305 ENOG4105CNT hydrolase family 2 ADZ27_08310 ENOG4105XEA Tetr family transcriptional regulator ADZ27_08315 ENOG4107ZQV short-chain dehydrogenase reductase ADZ27_08320 ENOG4107P2S Transcriptional regulator ADZ27_08325 ENOG4105CI1 PTS System ADZ27_08330 ENOG4105C87 Aminotransferase class I and II ADZ27_08340 ENOG4105D9R oxidoreductase ADZ27_08345 ENOG4106C6R beta-lactam resistance protein ADZ27_08350 ENOG4105QZ5 OriC-binding nucleoid-associated protein ADZ27_08355 ENOG4105M9B inner membrane protein ydgK ADZ27_08380 ENOG4108UQQ Electron transport complex ADZ27_08390 ENOG4105CSM endonuclease III ADZ27_08400 ENOG4105DUX Transporter ADZ27_08405 ENOG4108K3A Glutathione S-transferase ADZ27_08410 ENOG4107XGF functions in a salvage pathway. Uses pyridoxamine (By similarity) ADZ27_08425 ENOG410642K Lysozyme inhibitor ADZ27_08435 ENOG4108XTF Outer Membrane Lipoprotein ADZ27_08450 ENOG4105Y49 secretion protein, HlyD family ADZ27_08455 ENOG4105DSW Fusaric acid resistance protein ADZ27_08460 ENOG4108Z7T Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) ADZ27_08465 ENOG4107RGM aldo keto reductase ADZ27_08470 ENOG4105XZD Fe-S protein ADZ27_08475 ENOG4108WUH Transcriptional regulator, TetR family ADZ27_08480 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase ADZ27_08485 ENOG4108UYE Lactoylglutathione lyase ADZ27_08490 ENOG4105DH5 Responsible for the end-turnover of tRNA specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis (By similarity) ADZ27_08495 ENOG4107QRT dEAD DEAH box helicase ADZ27_08500 ENOG4105M2J Glutaredoxin ADZ27_08505 ENOG4105K4H Nlp p60 protein ADZ27_08510 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) ADZ27_08515 ENOG4105F27 Major Facilitator ADZ27_08530 ENOG4105F52 Transcriptional regulator ADZ27_08535 ENOG4105CZQ inner membrane transport protein YdhC ADZ27_08540 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase ADZ27_08545 ENOG4108R6K riboflavin synthase, subunit alpha ADZ27_08550 ENOG4105F2I Transposase ADZ27_08575 ENOG4105N0V mono-oxygenase ydhR ADZ27_08580 ENOG4108KTU conserved protein with FAD NAD(P)-binding domain ADZ27_08585 ENOG4108Y7C Conserved Protein ADZ27_08590 ENOG4108NWD Cytochrome ADZ27_08595 ENOG4108393 oxidoreductase Fe-S subunit ADZ27_08600 ENOG4105JVW ADZ27_08605 ENOG4105WE2 aldehyde ferredoxin oxidoreductase ADZ27_08610 ENOG4108PU5 4fe-4S ferredoxin, iron-sulfur binding domain protein ADZ27_08615 ENOG4105RFR Protein of unknown function (DUF2767) ADZ27_08620 ENOG4105CA9 Pyruvate kinase ADZ27_08625 ENOG4105KMX major outer membrane lipoprotein ADZ27_08630 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein ADZ27_08645 ENOG4105JRK feS assembly protein SufD ADZ27_08650 ENOG4105C3K feS assembly ATPase SufC ADZ27_08655 ENOG4105DIW FeS assembly protein SUFB ADZ27_08660 ENOG4108Z4V iron-sulfur cluster assembly ADZ27_08665 ENOG410671Z uncharacterized protein ydiH ADZ27_08670 ENOG4105KA0 thioesterase Superfamily protein ADZ27_08675 ENOG4105CQB FAD linked oxidase domain protein ADZ27_08680 ENOG4105IPI Membrane ADZ27_08685 ENOG4105SUA Ydil protein ADZ27_08690 ENOG4105EMV Major Facilitator ADZ27_08695 ENOG4105EMV Major Facilitator ADZ27_08710 ENOG4107R0K CoA transferase having broad substrate specificity for short-chain acyl-CoA thioesters with the activity decreasing when the length of the carboxylic acid chain exceeds four carbons (By similarity) ADZ27_08715 ENOG4105C1G acyl-Coa dehydrogenase ADZ27_08720 ENOG4105W4W Transcriptional regulator ADZ27_08730 ENOG4105CV7 Electron transfer flavoprotein ADZ27_08735 ENOG4105C10 Electron transfer flavoprotein ADZ27_08740 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase ADZ27_08745 ENOG41090P5 ferredoxin-like protein ADZ27_08750 ENOG4105CEY Amp-dependent synthetase and ligase ADZ27_08755 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) ADZ27_08770 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) ADZ27_08775 ENOG4106EDX Hemin uptake protein ADZ27_08785 ENOG4108TC0 Diguanylate phosphodiesterase ADZ27_08790 ENOG4108QBX (LipO)protein ADZ27_08800 ENOG4108V06 Glutathione peroxidase ADZ27_08815 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) ADZ27_08830 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) ADZ27_08835 ENOG41082NX 50s ribosomal protein l35 ADZ27_08860 ENOG4108NE3 Salt-induced outer membrane protein ADZ27_08865 ENOG4105DE4 1-phosphofructokinase ADZ27_08870 ENOG4105P10 Uncharacterized protein ydiZ ADZ27_08875 ENOG4105FGM Fructosamine kinase ADZ27_08880 ENOG4107PN8 YfeABCD locus regulator ADZ27_08885 ENOG4107UW8 HAD-superfamily hydrolase subfamily IA variant 3 ADZ27_08890 ENOG4107K5X Membrane-bound metal-dependent hydrolase ADZ27_08895 ENOG4108ETY sodium dicarboxylate symporter ADZ27_08910 ENOG4105CH6 catalase ADZ27_08920 ENOG4105F8D glycoside hydrolase family 4 ADZ27_08925 ENOG4105EZV Transcriptional regulator ADZ27_08930 ENOG4105VCP PTS System ADZ27_08935 ENOG4105CK1 PTS System ADZ27_08940 ENOG4105VZJ PTS System ADZ27_08945 ENOG4105KKI DNA-binding transcriptional activator OsmE ADZ27_08960 ENOG4105DKD Incises the DNA at the 3' side of a lesion during nucleotide excision repair. Incises the DNA farther away from the lesion than UvrC. Not able to incise the 5' site of a lesion. When a lesion remains because UvrC is not able to induce the 3' incision, Cho incises the DNA. Then UvrC makes the 5' incision. The combined action of Cho and UvrC broadens the substrate range of nucleotide excision repair (By similarity) ADZ27_08970 ENOG4108SPG Periplasmic Protein ADZ27_08990 ENOG4105F4X arginine ADZ27_09000 ENOG4105CGK Exodeoxyribonuclease III ADZ27_09005 ENOG4108RSN SNARE associated Golgi ADZ27_09010 ENOG4108KCW iron-sulfur cluster binding ADZ27_09015 ENOG4108N5C SNARE associated Golgi protein-related protein ADZ27_09020 ENOG4107ZN8 Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) ADZ27_09025 ENOG4105VNH ABC transporter solute-binding protein ADZ27_09030 ENOG4105CXZ ABC transporter, permease ADZ27_09035 ENOG4108VGW abc transporter atp-binding protein ADZ27_09040 ENOG4107RM6 sulfurtransferase ADZ27_09045 ENOG4108T9J Cdp-alcohol phosphatidyltransferase ADZ27_09050 ENOG4105M6F mutator MutT protein ADZ27_09055 ENOG4105MTM Protein of unknown function (DUF1496) ADZ27_09060 ENOG4105D82 Glutamate dehydrogenase ADZ27_09065 ENOG41065FB inner membrane protein ynji ADZ27_09070 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) ADZ27_09085 ENOG41069NU Nitroreductase ADZ27_09095 ENOG4105D07 Signal peptide peptidase, SppA ADZ27_09100 ENOG4105HDK L-asparaginase ADZ27_09105 ENOG4108RWI nicotinamidase ADZ27_09110 ENOG4108KUU Inner membrane metabolite transport protein ydjE ADZ27_09115 ENOG4105E98 transcriptional regulator DeoR family ADZ27_09120 ENOG4105CPC Aldo Keto reductase ADZ27_09125 ENOG4107UH8 sugar kinase ADZ27_09130 ENOG4105D2N Aldolase ADZ27_09135 ENOG4105CPQ Dehydrogenase ADZ27_09140 ENOG4107TE1 transport protein ADZ27_09145 ENOG4105CPQ Dehydrogenase ADZ27_09150 ENOG4105VUT cytoplasmic protein ADZ27_09160 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase ADZ27_09165 ENOG4105DSB aldose 1-epimerase ADZ27_09170 ENOG4105CV8 reductase ADZ27_09175 ENOG4105GNX MltA-interacting MipA family protein ADZ27_09180 ENOG4105CYN Serine protein kinase ADZ27_09190 ENOG4106KTS Inner membrane protein yeaI ADZ27_09195 ENOG4108KHP Diguanylate cyclase ADZ27_09200 ENOG4108KXH Ybak prolyl-tRNA synthetase associated ADZ27_09215 ENOG4105R1U AraC Family Transcriptional Regulator ADZ27_09220 ENOG4105DJ2 Major Facilitator Superfamily ADZ27_09225 ENOG4105K78 MarR family Transcriptional regulator ADZ27_09230 ENOG4105UCG Domain of unknown function (DUF333) ADZ27_09235 ENOG410620I Diguanylate cyclase ADZ27_09240 ENOG4106G4W ADZ27_09245 ENOG4105Y3U Transglycosylase-associated protein ADZ27_09250 ENOG4105YP6 Domain of unknown function (DUF1869) ADZ27_09255 ENOG4108YS1 cytoplasmic protein ADZ27_09265 ENOG4105EJC lysr family transcriptional regulator ADZ27_09270 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) ADZ27_09275 ENOG4105C94 Transporter ADZ27_09280 ENOG4105DVW rieske (2Fe-2S) ADZ27_09285 ENOG4105E3J oxidoreductase ADZ27_09290 ENOG4105ZIE Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity) ADZ27_09295 ENOG4105CEY Amp-dependent synthetase and ligase ADZ27_09300 ENOG4105Y4Z Outer Membrane Lipoprotein ADZ27_09305 ENOG41072GX Peptidase M22 Glycoprotease ADZ27_09310 ENOG4105DVT helicase ADZ27_09315 ENOG4105M4H endoribonuclease L-psp ADZ27_09320 ENOG4105V2F Uncharacterized protein yoac ADZ27_09330 ENOG4105CRQ synthase (Component I) ADZ27_09340 ENOG4105EJQ L-serine dehydratase ADZ27_09345 ENOG4107XTP (EAL) domain protein ADZ27_09350 ENOG4105EE5 Membrane protein terC ADZ27_09360 ENOG4108EQA pts system ADZ27_09365 ENOG4105ETZ PTS System ADZ27_09370 ENOG4105F3R pts system mannose fructose sorbose family iid ADZ27_09390 ENOG4105DHI Methyltransferase ADZ27_09395 ENOG4105VEQ Cold shock protein ADZ27_09400 ENOG410610J Protein of unknown function (DUF2627) ADZ27_09410 ENOG4105Q3Y exported protein ADZ27_09420 ENOG4105TIK ADZ27_09430 ENOG4105F2I Transposase ADZ27_09435 ENOG4105J4Q Transcriptional regulator ADZ27_09440 ENOG4105C0R drug resistance transporter emrb qaca subfamily ADZ27_09450 ENOG4105CN1 protease ADZ27_09460 ENOG4108ZGC gaf domain protein ADZ27_09465 ENOG4105H2K paraquat-inducible protein a ADZ27_09470 ENOG4105DY2 Paraquat-inducible protein b ADZ27_09480 ENOG4105WT8 Protein of unknown function (DUF1480) ADZ27_09485 ENOG4105UVW uncharacterized protein yebW ADZ27_09490 ENOG4108R1E Serine threonine protein phosphatase 1 ADZ27_09500 ENOG4105NKT exported protein ADZ27_09505 ENOG4108PNC copper resistance ADZ27_09510 ENOG4105FXM Copper resistance protein ADZ27_09515 ENOG4105MPK DNA polymerase III subunit theta ADZ27_09520 ENOG4108YGA nitrilase cyanide hydratase and apolipoprotein n-acyltransferase ADZ27_09525 ENOG4105UMD exodeoxyribonuclease X ADZ27_09530 ENOG4105CUG Oligopeptidase b ADZ27_09535 ENOG4108Q2J Inner membrane protein YebE ADZ27_09545 ENOG4105RSZ secreted protein ADZ27_09550 ENOG4105X2V dna damage-inducible protein ADZ27_09560 ENOG4108UHU Aldolase ADZ27_09565 ENOG4105C01 Dihydroxy-acid dehydratase ADZ27_09570 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase ADZ27_09580 ENOG4106KNT transcriptional regulator ADZ27_09585 ENOG4105CA9 Pyruvate kinase ADZ27_09590 ENOG4105NWR lipid A biosynthesis (Kdo)2-(Lauroyl)-lipid IVA acyltransferase ADZ27_09595 ENOG4105DR5 peptidase ADZ27_09600 ENOG4105NXV High-affinity zinc uptake system protein ADZ27_09605 ENOG4105FDK ABC transporter ADZ27_09610 ENOG4105FAV ABC, transporter ADZ27_09625 ENOG4107S01 Repressor protein MetJ ADZ27_09635 ENOG4105CDY transcriptional regulatory protein ADZ27_09640 ENOG4108TIT dATP pyrophosphohydrolase ADZ27_09650 ENOG4105D3W isochorismatase ADZ27_09655 ENOG41081XQ Conserved Protein ADZ27_09660 ENOG4105WJG Glutathione ADZ27_09675 ENOG4107QY8 reductase ADZ27_09680 ENOG4105CUW cytochrome C-TYPE protein ADZ27_09690 ENOG4106ZCM YecM protein ADZ27_09705 ENOG4105W13 flagellar protein ADZ27_09710 ENOG4105D7B Flagellar biosynthesis protein flha ADZ27_09715 ENOG4105D00 flagellar biosynthetic protein flhB ADZ27_09720 ENOG4108KCC Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P) (By similarity) ADZ27_09725 ENOG4108VYJ response regulator receiver protein ADZ27_09730 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) ADZ27_09735 ENOG4105BZU Histidine kinase ADZ27_09740 ENOG4105C8Q Methyl-accepting chemotaxis ADZ27_09745 ENOG4105C8Q Methyl-accepting chemotaxis ADZ27_09750 ENOG4108V3W Chemotaxis protein, CheW ADZ27_09755 ENOG4105CBS Chea signal transduction histidine kinase ADZ27_09760 ENOG4105ER2 Ompa motb domain protein ADZ27_09765 ENOG4107RD7 Flagellar Motor Protein, MotA ADZ27_09770 ENOG4106CIA Functions in complex with FlhD as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region ADZ27_09780 ENOG4108VA4 Universal stress protein ADZ27_09790 ENOG4108K4C ec 3.1.3.12 ADZ27_09795 ENOG4105CNN ABC, transporter ADZ27_09800 ENOG4105C2J ABC transporter ADZ27_09805 ENOG4105DMK Periplasmic binding protein LacI transcriptional regulator ADZ27_09810 ENOG4108UEC Ferritin-like protein ADZ27_09815 ENOG4105N4N Protein of unknown function (DUF2766) ADZ27_09825 ENOG4105P23 (LipO)protein ADZ27_09830 ENOG41090A1 ferritin ADZ27_09835 ENOG4105VVZ metal-binding protein ADZ27_09840 ENOG4105E0U tyrosine-specific transport protein ADZ27_09845 ENOG4106RHG Yeca family ADZ27_09865 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase ADZ27_09875 ENOG4105WH1 Two component transcriptional regulator luxr family ADZ27_09885 ENOG4105XVG cytoplasmic protein ADZ27_09890 ENOG4105VJY transcriptional regulator ADZ27_09895 ENOG4105CDA abc transporter atp-binding protein ADZ27_09900 ENOG4105E5Q amino acid AbC transporter ADZ27_09910 ENOG4105EAB amino acid AbC transporter ADZ27_09915 ENOG4108M9K flagella biosynthesis protein FliZ ADZ27_09920 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) ADZ27_09925 ENOG4105I03 Flagellin ADZ27_09930 ENOG4105DTS flagellar hook-associated ADZ27_09935 ENOG4105MQ3 flagellar protein FliS ADZ27_09940 ENOG4105YXP it directly binds FlhC, thus inhibiting the binding of the FlhC FlhD complex to class 2 promoters, resulting in decreased expression of class 2 flagellar operons. As a chaperone, effects FliD transition to the membrane by preventing its premature polymerization, and by directing it to the export apparatus (By similarity) ADZ27_09945 ENOG4105E5K Alpha-amylase ADZ27_09950 ENOG4108W9D (LipO)protein ADZ27_09955 ENOG41066VF YeeE YedE family protein ADZ27_09960 ENOG4105KSU Redox protein ADZ27_09965 ENOG4108RAV Conserved protein ADZ27_09970 ENOG4108HF7 Gcn5-related n-acetyltransferase ADZ27_09995 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) ADZ27_10000 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) ADZ27_10005 ENOG41090PJ Flagellar assembly protein ADZ27_10010 ENOG4108JIR Flagellum-specific ATP synthase ADZ27_10015 ENOG4105GSA Flagellar export protein flij ADZ27_10020 ENOG4105WF4 Flagellar hook-length control protein ADZ27_10025 ENOG4107ZI8 flagellar basal body-associated protein flil ADZ27_10030 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) ADZ27_10035 ENOG4105DD5 Flagellar motor switch protein ADZ27_10040 ENOG4105K0P flagellar biosynthesis protein ADZ27_10045 ENOG4105CN7 Flagellar biosynthetic protein FliP ADZ27_10050 ENOG4105VS8 Flagellar biosynthetic protein fliq ADZ27_10055 ENOG4105D19 Role in flagellar biosynthesis (By similarity) ADZ27_10060 ENOG4107TKS colanic acid capsular biosynthesis activation protein A ADZ27_10070 ENOG4105YX3 cellular response to acidity ADZ27_10080 ENOG4105BZU Histidine kinase ADZ27_10085 ENOG4105VNZ cytoplasmic protein ADZ27_10090 ENOG4105CKW Inner membrane protein yedI ADZ27_10095 ENOG4105FDR Membrane ADZ27_10100 ENOG41090BB DNA mismatch endonuclease (vsr) ADZ27_10105 ENOG4105DVF Cytosine-specific methyltransferase ADZ27_10110 ENOG4105EST Metal Dependent Phosphohydrolase ADZ27_10115 ENOG4105Y0K Inner membrane protein YedR ADZ27_10140 ENOG4107ZY3 Histidine kinase ADZ27_10145 ENOG4105CK6 Two component transcriptional regulator (Winged helix family ADZ27_10150 ENOG4105VT2 5-hydroxyisourate hydrolase ADZ27_10165 ENOG4108MEK Metal-binding protein YodA ADZ27_10170 ENOG4108VKM cytochrome b561 ADZ27_10185 ENOG4105EXZ Involved in the regulation of ptsG expression by binding and inactivating Mlc (By similarity) ADZ27_10195 ENOG4105TNG K13735 adhesin invasin ADZ27_10205 ENOG4105CSH Transporter ADZ27_10210 ENOG4105FYV Amp nucleosidase ADZ27_10215 ENOG4105CDY transcriptional regulatory protein ADZ27_10225 ENOG4105UQX Mate efflux family protein ADZ27_10235 ENOG4107R11 Transcriptional regulator ADZ27_10240 ENOG4106P55 Transcriptional regulator ADZ27_10250 ENOG4108PXI ErfK YbiS YcfS YnhG ADZ27_10265 ENOG4108YZT Adenosylcobinamide kinase ADZ27_10275 ENOG4105F2I Transposase ADZ27_10285 ENOG4108MVM Transposase ADZ27_10290 ENOG4108ZQS transposase ADZ27_10295 ENOG4105D05 Receptor ADZ27_10305 ENOG4105F4K antigen 43 ADZ27_10315 ENOG4108YGG dna repair protein ADZ27_10320 ENOG4106WJE Protein of unknown function (DUF987) ADZ27_10325 ENOG4105MAW Antitoxin component of a toxin-antitoxin (TA) module. Labile antitoxin that counteracts the effect of the CbtA (YeeV) toxin. It does not bind to the cognate toxin but instead binds to MreB and FtsZ (the toxin targets), enhancing their polymerization by forming higher-order bundles ADZ27_10355 ENOG4105DR8 Membrane ADZ27_10360 ENOG4108S5C Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell (By similarity) ADZ27_10365 ENOG4105DZ1 carboxypeptidase ADZ27_10370 ENOG4105CJB Exodeoxyribonuclease I ADZ27_10380 ENOG4105CUC YeeE YedE family protein ADZ27_10385 ENOG4105CUB amino acid ADZ27_10390 ENOG4105EQ1 Transcriptional regulator ADZ27_10395 ENOG4108535 NAD dependent epimerase/dehydratase family ADZ27_10400 ENOG4105KRQ Addiction module toxin, Txe YoeB family ADZ27_10405 ENOG4105VTW prevent-host-death family ADZ27_10415 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) ADZ27_10425 ENOG4105ECC imidazole-glycerol-phosphate dehydratase ADZ27_10430 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) ADZ27_10445 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase ADZ27_10450 ENOG4108KPN Confers a modal distribution of chain length on the O- antigen component of lipopolysaccharide (LPS). Gives rise to a reduced number of short chain molecules and increases in numbers of longer molecules, with a modal value of 13 (in strain O111 M92) and of 17 (in strain K12) ADZ27_10455 ENOG4105C6Y Udp-glucose 6-dehydrogenase ADZ27_10460 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) ADZ27_10465 ENOG4105F2I Transposase ADZ27_10475 ENOG4108TMJ glycosyl transferase ADZ27_10480 ENOG4108UW5 maltose o-acetyltransferase ADZ27_10485 ENOG4105GH9 galactofuranosyltransferase ADZ27_10490 ENOG4107B0W May link the O-antigen tetrasaccharide units into long chains, giving rise to typical smooth LPS ADZ27_10495 ENOG4105D5D udp-galactopyranose mutase ADZ27_10500 ENOG4105ER6 polysaccharide biosynthesis protein ADZ27_10505 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase ADZ27_10510 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) ADZ27_10520 ENOG4105C1B dTDP-glucose 4-6-dehydratase ADZ27_10525 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase ADZ27_10530 ENOG4105G1A colanic acid biosynthesis protein ADZ27_10535 ENOG4107T8Q Glycosyl transferase (Group 1 ADZ27_10540 ENOG4105C74 pyruvyl transferase ADZ27_10545 ENOG4105PSV Polysaccharide Biosynthesis Protein ADZ27_10550 ENOG4105D3Q Sugar transferase ADZ27_10555 ENOG4107QKV phosphomannomutase ADZ27_10560 ENOG4105CJT Mannose-1-phosphate guanylyltransferase ADZ27_10565 ENOG4106CD9 glycosyl transferase group 1 ADZ27_10570 ENOG4105FGF GDP-mannose mannosyl hydrolase ADZ27_10575 ENOG4105C30 Nad-dependent epimerase dehydratase ADZ27_10580 ENOG4105C0K Gdp-mannose 4,6-dehydratase ADZ27_10585 ENOG4108Z90 colanic acid biosynthesis acetyltransferase wcaF ADZ27_10590 ENOG4105ECJ Glycosyl Transferase ADZ27_10595 ENOG4108NYJ Colanic acid ADZ27_10600 ENOG4107RXY Glycosyl transferase ADZ27_10605 ENOG41068PY Colanic acid biosynthesis acetyltransferase wcaB ADZ27_10610 ENOG41090RK glycosyl transferase ADZ27_10615 ENOG4105D75 Capsular exopolysaccharide family ADZ27_10620 ENOG4105KJF protein tyrosine phosphatase ADZ27_10625 ENOG4105DAY polysaccharide export protein ADZ27_10630 ENOG4105EE5 Membrane protein terC ADZ27_10635 ENOG4108GAE asmA family ADZ27_10645 ENOG4105DBI uridine monophosphokinase ADZ27_10650 ENOG4105BZU Histidine kinase ADZ27_10655 ENOG4105D03 DNA-3-methyladenine glycosylase II ADZ27_10665 ENOG4105R8A Heat shock protein ADZ27_10670 ENOG4106E1W protein with protein kinase and helix-hairpin-helix DNA-binding ADZ27_10675 ENOG4105ZD5 Uncharacterized protein conserved in bacteria (DUF2314) ADZ27_10680 ENOG4105UM3 Inherit from NOG: serine threonine phosphoprotein phosphatase ADZ27_10685 ENOG4108M24 von Willebrand factor, type A ADZ27_10710 ENOG4105EB3 Histidine kinase ADZ27_10715 ENOG4105E3W Two component transcriptional regulator (Winged helix family ADZ27_10720 ENOG4105KWI UPF0339 protein ADZ27_10725 ENOG4105CFP Peptidase U32 ADZ27_10730 ENOG4105ZTC transcriptional activator, Ogr delta ADZ27_10740 ENOG41076Z6 Uncharacterized protein yegR ADZ27_10755 ENOG41090WB Transposase is3 is911 ADZ27_10770 ENOG4107WTH Galactitol-1-phosphate dehydrogenase ADZ27_10775 ENOG4105DT3 PTS system, galactitol-specific IIc component ADZ27_10780 ENOG4105F2I Transposase ADZ27_10790 ENOG41082GB PTS system galactitol-specific transporter subunit IIA ADZ27_10805 ENOG4105EIE fructose-bisphosphate aldolase ADZ27_10810 ENOG4105EAA nucleoside ADZ27_10815 ENOG4108KD5 ADP-ribosylation crystallin J1 ADZ27_10820 ENOG4108TFM Kinase, PfkB family ADZ27_10825 ENOG4105FDP GntR family transcriptional regulator ADZ27_10830 ENOG4108UQ1 hydrolase, family 25 ADZ27_10835 ENOG4105DWF phosphomethylpyrimidine kinase ADZ27_10850 ENOG41061MD high-affinity nickel-transporter ADZ27_10855 ENOG4108Z1S Influences nickel and cobalt homeostasis. May act by modulating RcnA-mediated export of these ions to avoid excess efflux. Not involved in nickel import and does not bind nickel or cobalt ions directly ADZ27_10860 ENOG410662B Type-1 fimbrial protein ADZ27_10865 ENOG4105CW0 outer membrane usher protein ADZ27_10870 ENOG4108MQF Chaperone ADZ27_10875 ENOG41063W2 Fimbrial protein ADZ27_10885 ENOG41067AK Protein of unknown function (DUF2574) ADZ27_10890 ENOG4105D1F ATP-binding protein ADZ27_10910 ENOG4108KDT Molybdate metabolism regulator ADZ27_10920 ENOG4105KKX ATPase associated with various cellular activities aaa_5 ADZ27_10925 ENOG4105RD5 ADZ27_10930 ENOG4105DEG Vwa containing coxe family protein ADZ27_10935 ENOG410903U zinc ion binding ADZ27_10940 ENOG4108YCW (LipO)protein ADZ27_10945 ENOG4108W15 Protein of unknown function (DUF1456) ADZ27_10950 ENOG4108NEV two component transcriptional regulator, LytTR family ADZ27_10955 ENOG4108HRK Histidine kinase ADZ27_10960 ENOG4108XDN Transcriptional regulator ADZ27_10970 ENOG4105WJV Binding-protein-dependent transport systems, inner membrane component ADZ27_10975 ENOG4108IJ8 ABC transporter ADZ27_10980 ENOG4107T5X Binding-protein-dependent transport systems, inner membrane component ADZ27_10985 ENOG4107SI7 Substrate-binding region of abc-type glycine betaine transport system ADZ27_10990 ENOG4107QK4 glycoside hydrolase, family 3 domain protein ADZ27_10995 ENOG4105CXG d-lactate dehydrogenase ADZ27_11000 ENOG41061WM D-Alanyl-D-Alanine ADZ27_11005 ENOG41069YE inner membrane protein yohC ADZ27_11010 ENOG4105KHU inner membrane protein YohD ADZ27_11015 ENOG4105H9W Short-chain dehydrogenase reductase Sdr ADZ27_11030 ENOG4105FBT Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity) ADZ27_11040 ENOG41067MG lrgb family ADZ27_11050 ENOG4107GZ4 SanA protein ADZ27_11055 ENOG4105Y9N Membrane ADZ27_11060 ENOG4105BZ8 glutamate synthase ADZ27_11065 ENOG4107SJI Dehydrogenase ADZ27_11070 ENOG4108HWV )-transporter ADZ27_11075 ENOG4105C2J ABC transporter ADZ27_11080 ENOG4105EMA Periplasmic binding protein LacI transcriptional regulator ADZ27_11085 ENOG41060NJ transcriptional regulator ADZ27_11095 ENOG4105DHF Membrane ADZ27_11110 ENOG4105C4W S-formylglutathione hydrolase ADZ27_11115 ENOG4105D05 Receptor ADZ27_11120 ENOG4108IQI permease ADZ27_11125 ENOG4105DUM transcriptional regulator, lysR family ADZ27_11130 ENOG4105HMI Membrane ADZ27_11135 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) ADZ27_11140 ENOG4105DD7 kinase (PfkB family ADZ27_11145 ENOG4105D9N nucleoside ADZ27_11155 ENOG4108Y4K DNA-binding transcriptional activator ADZ27_11160 ENOG4105D9N nucleoside ADZ27_11165 ENOG4105D53 Catalyzes the hydrolysis of pseudouridine 5'-phosphate (PsiMP) to ribose 5-phosphate and uracil (By similarity) ADZ27_11170 ENOG4105DD7 kinase (PfkB family ADZ27_11175 ENOG4105DM4 PTS System ADZ27_11180 ENOG4105DE4 1-phosphofructokinase ADZ27_11185 ENOG4105DTZ bifunctional PTS system fructose-specific transporter subunit IIA HPr protein ADZ27_11190 ENOG4105S8Q sugar efflux transporter ADZ27_11195 ENOG4105KRS Proteinase inhibitor ADZ27_11205 ENOG4105DEI Mannitol dehydrogenase ADZ27_11210 ENOG4105CKI cobalamin synthesis protein ADZ27_11215 ENOG41076MN Phosphoesterase, PA-phosphatase related ADZ27_11220 ENOG4107TT5 NLP P60 protein ADZ27_11225 ENOG4105CXC rtn protein ADZ27_11230 ENOG4105E43 Extracellular solute-binding protein, family 5 ADZ27_11235 ENOG4108I5X binding-protein-dependent transport systems inner membrane Component ADZ27_11240 ENOG4108IYQ Binding-protein-dependent transport systems inner membrane component ADZ27_11245 ENOG4108JQ5 ABC transporter ADZ27_11250 ENOG4105HG6 ADZ27_11255 ENOG4105C2C drug resistance transporter, Bcr CflA ADZ27_11260 ENOG4105I08 Pseudouridine synthase ADZ27_11265 ENOG4105CFI type iii restriction protein res subunit ADZ27_11285 ENOG4105E68 Sulfatase ADZ27_11295 ENOG4108MGN ATP-binding component of a transport system ADZ27_11300 ENOG4105F2I Transposase ADZ27_11310 ENOG4105WH1 Two component transcriptional regulator luxr family ADZ27_11315 ENOG4105KWW Biogenesis protein ADZ27_11320 ENOG4107QX9 Thiol disulfide interChange protein ADZ27_11325 ENOG4105DA4 cytochrome c-type biogenesis protein ADZ27_11335 ENOG4105X3C heme exporter protein ADZ27_11340 ENOG41060IM Heme exporter protein ADZ27_11345 ENOG4105CA5 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes (By similarity) ADZ27_11350 ENOG4107EV4 once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system (By similarity) ADZ27_11355 ENOG4105CUW cytochrome C-TYPE protein ADZ27_11360 ENOG4108ZMS Electron transfer subunit of the periplasmic nitrate reductase complex NapAB (By similarity) ADZ27_11365 ENOG4105GXZ Ferredoxin-type protein NapH ADZ27_11370 ENOG4108BGM Quinol dehydrogenase periplasmic component ADZ27_11380 ENOG41061Q0 Assembly protein for periplasmic nitrate reductase ADZ27_11385 ENOG4108ZNS ferredoxin-type protein NapF ADZ27_11405 ENOG4105IBP Cyclic peptide transporter ADZ27_11410 ENOG4105CF1 Alkylated DNA repair protein ADZ27_11415 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) ADZ27_11420 ENOG4105CJ2 (LipO)protein ADZ27_11425 ENOG4105FCK Membrane ADZ27_11440 ENOG4105E3G Phosphotransfer intermediate protein in two-component regulatory system with RcsBC ADZ27_11445 ENOG41068CG regulatoR ADZ27_11450 ENOG4105BZU Histidine kinase ADZ27_11455 ENOG4105BZU Histidine kinase ADZ27_11460 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family ADZ27_11465 ENOG4107QP7 CoA-transferase subunit A ADZ27_11470 ENOG4107QNJ CoA-transferase subunit B ADZ27_11475 ENOG4105CRW Short chain fatty acid transporter ADZ27_11480 ENOG4105CHU acetyl-coa acetyltransferase ADZ27_11485 ENOG4105EDV vault protein ADZ27_11490 ENOG41081SK signal peptide protein ADZ27_11495 ENOG4107S52 alpha-2-macroglobulin domain protein ADZ27_11505 ENOG4108QJJ Protein of unknown function (DUF1175) ADZ27_11510 ENOG4107FKF Uncharacterized protein conserved in bacteria (DUF2138) ADZ27_11515 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) ADZ27_11525 ENOG4107GHC outer membrane autotransporter ADZ27_11535 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) ADZ27_11540 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) ADZ27_11545 ENOG4105XPH Ferredoxin ADZ27_11550 ENOG4105FQR PH-inducible protein involved in stress response ADZ27_11555 ENOG4107R11 Transcriptional regulator ADZ27_11560 ENOG4106MZZ glycerophosphoryl diester phosphodiesterase ADZ27_11565 ENOG4105CXY transporter ADZ27_11570 ENOG4107R5Y anaerobic glycerol-3-phosphate dehydrogenase, subunit A ADZ27_11580 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) ADZ27_11585 ENOG4105DNE Transposase ADZ27_11600 ENOG4105CSP Major Facilitator Superfamily ADZ27_11610 ENOG4107258 Transcriptional regulator ADZ27_11620 ENOG4108UII YfaZ family ADZ27_11650 ENOG4105F73 Catalyzes the deformylation of 4-deoxy-4-formamido-L- arabinose-phosphoundecaprenol to 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity) ADZ27_11655 ENOG4105SA9 Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity) ADZ27_11665 ENOG4105U65 Translocates 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol (alpha-L-Ara4N-phosphoundecaprenol) from the cytoplasmic to the periplasmic side of the inner membrane (By similarity) ADZ27_11670 ENOG4106GZG polymyxin resistance protein B ADZ27_11675 ENOG4105CEY Amp-dependent synthetase and ligase ADZ27_11685 ENOG4108IPT Naphthoate synthase ADZ27_11700 ENOG4105E4F Isochorismate synthase ADZ27_11705 ENOG4105TNS Conserved Protein ADZ27_11710 ENOG4107YB6 acetyltransferase, (GNAT) family ADZ27_11720 ENOG4105Z6G Protease that can act as an efficient and specific deubiquitinating enzyme in vitro. Does not possess desumoylating and deneddylating activities. The physiological substrate is ADZ27_11725 ENOG4105CP2 von willebrand factor, type a ADZ27_11730 ENOG4107VAM peptidase, m28 ADZ27_11735 ENOG4105GDX Domain of unknown function (DUF1877) ADZ27_11740 ENOG4105ZD8 ADZ27_11745 ENOG4106EES ADZ27_11750 ENOG4106HDC ADZ27_11760 ENOG4105C8S subunit m ADZ27_11765 ENOG4105D65 subunit l ADZ27_11770 ENOG41080EA NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) ADZ27_11775 ENOG4107UFS subunit j ADZ27_11780 ENOG4105P3U NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) ADZ27_11790 ENOG4107R0R NADH dehydrogenase subunit g ADZ27_11795 ENOG4107QIZ NADH dehydrogenase ADZ27_11800 ENOG4105GKE subunit e ADZ27_11805 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) ADZ27_11820 ENOG4107NQ8 LysR family Transcriptional regulator ADZ27_11825 ENOG4105CHM Aminotransferase ADZ27_11835 ENOG4107QWE )-transporter ADZ27_11840 ENOG4105EVE HAD-superfamily hydrolase subfamily IA variant 3 ADZ27_11860 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) ADZ27_11865 ENOG4105C6K Malic enzyme ADZ27_11870 ENOG4105CSX c4-dicarboxylate anaerobic carrier ADZ27_11875 ENOG4105PTV Nudix Hydrolase ADZ27_11880 ENOG4108RE9 Phosphodiesterase ADZ27_11885 ENOG4108SHQ Glutathione S-transferase ADZ27_11890 ENOG4105CYM Glutathione S-transferase ADZ27_11895 ENOG4105KKP D-erythro-7,8-dihydroneopterin triphosphate 2'-epimerase ADZ27_11900 ENOG4105ECP epimerase ADZ27_11905 ENOG4105DNE Transposase ADZ27_11910 ENOG4108JEH abc transporter atp-binding protein ADZ27_11915 ENOG4106YG3 ABC transporter ADZ27_11920 ENOG4105DSP amino acid AbC transporter ADZ27_11925 ENOG4105E89 ABC transporter ADZ27_11930 ENOG4105E89 ABC transporter ADZ27_11935 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase ADZ27_11940 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase ADZ27_11945 ENOG4105E96 Colicin v production protein ADZ27_11950 ENOG4108S3P Sporulation domain protein ADZ27_11955 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase ADZ27_11965 ENOG4105DQR SNARE associated Golgi ADZ27_11975 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) ADZ27_11985 ENOG4106WZ1 flagella biosynthesis regulator ADZ27_11990 ENOG4105F9N Major Facilitator Superfamily ADZ27_11995 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) ADZ27_12000 ENOG4105CWG Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity) ADZ27_12005 ENOG4105MH2 YfcL protein ADZ27_12010 ENOG4108BPE -transporting atpase ADZ27_12015 ENOG4105EJ9 Membrane ADZ27_12030 ENOG4105C76 Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity) ADZ27_12045 ENOG4105US4 fimbrial-like protein yfcP ADZ27_12050 ENOG4105UGQ Fimbrial ADZ27_12055 ENOG4105NEV Fimbrial ADZ27_12060 ENOG4108FZ9 Chaperone ADZ27_12075 ENOG4108BY2 phosphohistidine phosphatase ADZ27_12090 ENOG4105KZW UPF0381 protein ADZ27_12095 ENOG4105CKF membrane protein involved in aromatic hydrocarbon degradation ADZ27_12105 ENOG410903C (LipO)protein ADZ27_12110 ENOG4105S64 Formate nitrite transporter ADZ27_12120 ENOG4105DFP Integrase ADZ27_12125 ENOG4105IHM Involved in O antigen modification. Involved in the translocation of bactoprenol-linked glucose across the cytoplasmic membrane (By similarity) ADZ27_12130 ENOG4105CKK Glycosyl transferase, family 2 ADZ27_12145 ENOG4105PTU response to oxidative stress ADZ27_12165 ENOG4105YQ0 ADZ27_12170 ENOG4105H40 ADZ27_12175 ENOG4108HJ1 Uncharacterized conserved protein (DUF2303) ADZ27_12180 ENOG4108R7K Metal Dependent Phosphohydrolase ADZ27_12185 ENOG41077V0 CPS-53 (KpLE1) prophage ADZ27_12195 ENOG41065VV Transcription inhibitory protein for the torCAD operon. Also acts as an excisionase and plays an essential role in the defective prophage CPS53 excision ADZ27_12200 ENOG4105W8I Transcriptional regulator ADZ27_12205 ENOG4105C6Z Gluconate ADZ27_12215 ENOG4105C0R drug resistance transporter emrb qaca subfamily ADZ27_12220 ENOG4105CW7 secretion protein, HlyD family ADZ27_12225 ENOG4108WQH regulatoR ADZ27_12230 ENOG4105BZU Histidine kinase ADZ27_12235 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F ADZ27_12240 ENOG4108N2Y auxin Efflux ADZ27_12245 ENOG4105CFN oxalyl-CoA decarboxylase ADZ27_12255 ENOG4108V08 YfdX protein ADZ27_12270 ENOG4105W9M Membrane ADZ27_12275 ENOG4105D1S lipid A biosynthesis ADZ27_12280 ENOG4105CHM Aminotransferase ADZ27_12285 ENOG4108HRK Histidine kinase ADZ27_12290 ENOG4105DY9 regulatoR ADZ27_12295 ENOG4108CIP transcriptional regulator ADZ27_12300 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) ADZ27_12305 ENOG4105CN9 Peptidase m42 family protein ADZ27_12310 ENOG4105DC7 peptidase M24 ADZ27_12315 ENOG410863U PTS System ADZ27_12320 ENOG4105R6B The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane (By similarity) ADZ27_12330 ENOG4105VCT ion-transport protein YfeO ADZ27_12335 ENOG4109076 Conserved Protein ADZ27_12350 ENOG4105D9N nucleoside ADZ27_12355 ENOG4108SER Transposase ADZ27_12360 ENOG4108KMM Diguanylate cyclase ADZ27_12375 ENOG4105HZG regulatoR ADZ27_12380 ENOG4105GXM Putative transcription regulator (DUF1323) ADZ27_12410 ENOG4105CN8 Transcriptional regulator ADZ27_12420 ENOG4105EAA nucleoside ADZ27_12425 ENOG4107U5R The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity) ADZ27_12430 ENOG4108NFH Sugar hydrolase ADZ27_12435 ENOG4108M0I Transcriptional regulator ADZ27_12440 ENOG4105DHU Bile acid ADZ27_12445 ENOG4105VRT cytoplasmic protein ADZ27_12450 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) ADZ27_12465 ENOG4105C6T cysteine synthase ADZ27_12470 ENOG4105KZ7 phosphocarrier protein hpr ADZ27_12475 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) ADZ27_12480 ENOG4105C5Y PTS System ADZ27_12490 ENOG4105M0Y ADZ27_12495 ENOG4105WEC Molybdate metabolism regulator ADZ27_12500 ENOG4105C6T cysteine synthase ADZ27_12505 ENOG4108IJ6 ABC transporter ADZ27_12510 ENOG4105ECW sulfate abc transporter ADZ27_12515 ENOG4108I5D sulfate abc transporter ADZ27_12520 ENOG4108J2H Sulfate ABC transporter periplasmic sulfate-binding protein ADZ27_12525 ENOG4105I7Z Short-chain dehydrogenase reductase Sdr ADZ27_12540 ENOG4105C5Y PTS System ADZ27_12545 ENOG4107S1E Beta-lactamase ADZ27_12550 ENOG4105EZR dyp-type peroxidase family protein ADZ27_12555 ENOG4105E7K (LipO)protein ADZ27_12560 ENOG4105QZU Inner membrane protein YfeZ ADZ27_12565 ENOG4108R6G acetyltransferase ADZ27_12570 ENOG4108KNB n-acetylmuramoyl-l-alanine amidase ADZ27_12580 ENOG4108K3Z AraC family transcriptional regulator ADZ27_12585 ENOG4108X49 Ethanolamine utilization protein EutK ADZ27_12590 ENOG4106D67 ethanolamine utilization protein ADZ27_12600 ENOG4105CPD ethanolamine ammonia-lyase ADZ27_12605 ENOG4105DYY Reactivating factor for ethanolamine ammonia lyase ADZ27_12610 ENOG4105ENY Ethanolamine utilization protein eutH ADZ27_12615 ENOG4105C0A alcohol dehydrogenase ADZ27_12620 ENOG4107RWI ethanolamine utilization protein eutJ ADZ27_12625 ENOG4108EKI Dehydrogenase ADZ27_12630 ENOG4105WVM ethanolamine utilization protein EutN carboxysome structural protein Ccml ADZ27_12635 ENOG4105KNY Microcompartments protein ADZ27_12640 ENOG4107WUY phosphate acetyltransferase ADZ27_12645 ENOG4108PFF ethanolamine utilization cobalamin adenosyltransferase ADZ27_12650 ENOG4105NDK ethanolamine utilization protein ADZ27_12655 ENOG4106S4J ethanolamine utilization protein EutP ADZ27_12660 ENOG4108VJN May be involved in the formation of a specific microcompartment in the cell in which the metabolism of potentially toxic by-products takes place ADZ27_12665 ENOG4105C6K Malic enzyme ADZ27_12670 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) ADZ27_12675 ENOG4105CV1 Transketolase (EC 2.2.1.1) ADZ27_12680 ENOG4108PVD exported protein ADZ27_12685 ENOG4107VIJ nudix hydrolase ADZ27_12690 ENOG4105BZ8 glutamate synthase ADZ27_12695 ENOG4105BZU Histidine kinase ADZ27_12700 ENOG4105BZS acriflavin resistance protein ADZ27_12710 ENOG4105KUZ arsenate reductase ADZ27_12725 ENOG4106KED esterase YpfH ADZ27_12730 ENOG4105E0I Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP) (By similarity) ADZ27_12735 ENOG4105CGZ zinc metallopeptidase ADZ27_12750 ENOG4107EG0 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) ADZ27_12760 ENOG4105RH4 Glycine cleavage system transcriptional repressor ADZ27_12765 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen ADZ27_12770 ENOG4108MFN small subunit of hydrogenase-3, iron-sulfur protein (part of formate hydrogenlyase (FHL) complex) ADZ27_12775 ENOG4108JPZ Monovalent cation H antiporter subunit D ADZ27_12780 ENOG4107TDF Formate hydrogenlyase subunit 4 ADZ27_12785 ENOG4105D65 subunit l ADZ27_12790 ENOG4107WQX hydrogenase 4 membrane subunit ADZ27_12795 ENOG4108JPZ Monovalent cation H antiporter subunit D ADZ27_12800 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) ADZ27_12810 ENOG4105C47 NADH ubiquinone oxidoreductase 20 kda subunit ADZ27_12815 ENOG4105I6X formate hydrogenlyase maturation ADZ27_12820 ENOG4108JUA Transcriptional regulator ADZ27_12825 ENOG4105TMB Formate nitrite transporter ADZ27_12830 ENOG4105C02 permease ADZ27_12835 ENOG4105ERG peptidase m48, ste24p ADZ27_12840 ENOG4105K89 arsenate reductase ADZ27_12850 ENOG4105C2W permease ADZ27_12865 ENOG4108V3E phosphoribosylglycinamide formyltransferase ADZ27_12870 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) ADZ27_12875 ENOG4105C9X ppx gppa phosphatase ADZ27_12880 ENOG4105BZU Histidine kinase ADZ27_12890 ENOG41062G3 Protein of unknown function (DUF2633) ADZ27_12895 ENOG4108ZMA Outer membrane lipoprotein ADZ27_12900 ENOG41066DY Membrane ADZ27_12910 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) ADZ27_12920 ENOG4105VPD cellular component movement ADZ27_12930 ENOG4105CNE Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) ADZ27_12935 ENOG4105N21 Membrane ADZ27_12965 ENOG4108JQB penicillin-binding protein 1C ADZ27_12970 ENOG4105DN3 alpha-2-macroglobulin domain protein ADZ27_12975 ENOG4105KHC sulfurtransferase ADZ27_12980 ENOG4105YYA enhanced serine sensitivity protein SseB ADZ27_12990 ENOG4105WVQ Fe-S assembly protein IscX ADZ27_12995 ENOG4108ZIT Ferredoxin, 2FE-2S ADZ27_13015 ENOG4107XTC May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins ADZ27_13040 ENOG4107XM9 (LipO)protein ADZ27_13045 ENOG4108MN2 Stationary phase inducible protein CsiE ADZ27_13050 ENOG4105D8G Major Facilitator superfamily ADZ27_13055 ENOG4108W5M transcriptional regulator ADZ27_13060 ENOG4105FUY alpha subunit ADZ27_13085 ENOG4108SB3 DoxX Family ADZ27_13090 ENOG4108ZKT aldose 1-epimerase ADZ27_13095 ENOG4105CPQ Dehydrogenase ADZ27_13100 ENOG4105CNN ABC, transporter ADZ27_13105 ENOG4108F37 ATP-binding component of a transport system ADZ27_13110 ENOG4105FCA ABC transporter periplasmic-binding protein YphF ADZ27_13115 ENOG4107HQ7 repeat protein ADZ27_13120 ENOG4108NZE NAGC-like transcriptional regulator ADZ27_13130 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) ADZ27_13135 ENOG4108YZA Nitrogen regulatory protein pii ADZ27_13140 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family ADZ27_13145 ENOG4108SKK alpha helix protein ADZ27_13150 ENOG4107WP9 Histidine kinase ADZ27_13155 ENOG4107QIK phosphoribosylformylglycinamidine synthase ADZ27_13165 ENOG4108Z6B deaminase ADZ27_13170 ENOG4105HYY HAD superfamily (Subfamily IF) hydrolase, YfhB ADZ27_13175 ENOG4106G6Q Transcriptional regulator ADZ27_13180 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding ADZ27_13205 ENOG4105CSZ Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity) ADZ27_13225 ENOG4105C3F Signal peptidase i ADZ27_13235 ENOG4105WMJ Positive regulator of sigma E, RseC MucC ADZ27_13240 ENOG4105VQK sigma E regulatory protein, MucB RseB ADZ27_13245 ENOG41069PW sigma-e factor negative regulatory protein ADZ27_13250 ENOG4105EMN RNA polymerase sigma factor ADZ27_13260 ENOG4108IYU L-aspartate oxidase ADZ27_13265 ENOG4107S47 Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC) (By similarity) ADZ27_13270 ENOG4105C1J atp-dependent rna helicase ADZ27_13280 ENOG41090KR LysR family transcriptional Regulator ADZ27_13300 ENOG4105EIB trna rrna methyltransferase ADZ27_13310 ENOG4105K63 Thioredoxin ADZ27_13315 ENOG4106IUH DTW domain containing protein ADZ27_13320 ENOG4105CD5 CoA-binding domain protein ADZ27_13325 ENOG4105JIM Phosphatidylserine synthase ADZ27_13330 ENOG4105T42 (LipO)protein ADZ27_13335 ENOG4105CSH Transporter ADZ27_13365 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit ADZ27_13370 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase ADZ27_13375 ENOG4105C34 Pseudouridine synthase ADZ27_13380 ENOG4106SNF Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane ADZ27_13390 ENOG4108WPH sigma 54 modulation protein ribosomal protein S30EA ADZ27_13395 ENOG4105CQC Prephenate dehydratase ADZ27_13400 ENOG4105EHE chorismate mutase- prephenate dehydrogenase ADZ27_13405 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) ADZ27_13410 ENOG4105QP9 Protein of unknown function (DUF2799) ADZ27_13415 ENOG4108WS1 ADZ27_13420 ENOG4108KHX Diguanylate cyclase ADZ27_13425 ENOG41090EK ompa motb domain protein ADZ27_13450 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY ADZ27_13455 ENOG4106KVJ cytochrome C assembly protein ADZ27_13460 ENOG4108JU6 CBS domain protein ADZ27_13480 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) ADZ27_13485 ENOG4105YRI Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) ADZ27_13490 ENOG4105VDB UPF0125 protein ADZ27_13495 ENOG4108Z1B Cyclase dehydrase ADZ27_13505 ENOG4105DFP Integrase ADZ27_13510 ENOG4106QCB CP4-57 prophage ADZ27_13515 ENOG410679B prophage CP4-57 regulatory protein alpA ADZ27_13520 ENOG4108P8R ADZ27_13525 ENOG4105H5P transposase ADZ27_13530 ENOG4107UNZ domain protein ADZ27_13535 ENOG4105JPW Domain of unknown function (DUF1837) ADZ27_13540 ENOG4107NPW Protein of unknown function (DUF1524) ADZ27_13545 ENOG4106K8T Toxic component of a toxin-antitoxin (TA) module. A stable (half-life 27.6 minutes) endoribonuclease that in the absence of cognate antitoxin RnlB causes generalized RNA degradation. Degrades late enterobacteria phage T4 mRNAs, protecting the host against T4 reproduction. Activity is inhibited by cognate antitoxin RnlB and by enterobacteria phage T4 protein Dmd. Targets cyaA mRNA ADZ27_13550 ENOG4106BHJ Antitoxin component of a toxin-antitoxin (TA) module. A labile antitoxin (half-life of 2.1 minutes) that inhibits the endonuclease activity of cognate toxin RnlA but not that of non- cognate toxin LsoA ADZ27_13555 ENOG4105TS0 gtp-binding protein ADZ27_13560 ENOG4106H6R UPF0380 protein ADZ27_13565 ENOG4108KZE transcriptional regulator ADZ27_13580 ENOG4106J9S Prophage ADZ27_13600 ENOG4105MFG Antirestriction protein ADZ27_13605 ENOG4108XS9 dna repair protein ADZ27_13610 ENOG4105MAW Antitoxin component of a toxin-antitoxin (TA) module. Labile antitoxin that counteracts the effect of the CbtA (YeeV) toxin. It does not bind to the cognate toxin but instead binds to MreB and FtsZ (the toxin targets), enhancing their polymerization by forming higher-order bundles ADZ27_13615 ENOG4108X3P Toxic component of a toxin-antitoxin (TA) module. Overexpression results in inhibition of growth in liquid cultures ADZ27_13620 ENOG4108MGN ATP-binding component of a transport system ADZ27_13655 ENOG4105E54 alpha-amylase ADZ27_13660 ENOG4105E54 alpha-amylase ADZ27_13665 ENOG4105E54 alpha-amylase ADZ27_13675 ENOG4105D5U fad dependent oxidoreductase ADZ27_13680 ENOG4105C26 Dehydrogenase ADZ27_13685 ENOG4108JPW Aminotransferase ADZ27_13690 ENOG4105C85 amino acid ADZ27_13695 ENOG4108PVQ transcriptional regulator ADZ27_13700 ENOG4109066 lysm domain bon superfamily protein ADZ27_13705 ENOG4105VPI YqaE family transport protein ADZ27_13710 ENOG41080HT Transcriptional regulator, arsr family ADZ27_13715 ENOG4108V62 Rhodanese domain protein ADZ27_13720 ENOG4108X73 DNA- binding protein ADZ27_13725 ENOG4108RNS Exports L-alanine (By similarity) ADZ27_13730 ENOG4108WMJ Protein of unknown function (DUF2002) ADZ27_13735 ENOG4108ZQZ Bacterial protein of unknown function (DUF883) ADZ27_13740 ENOG4105WAZ (Glutaredoxin-like protein) NrdH ADZ27_13745 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) ADZ27_13750 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) ADZ27_13755 ENOG4107R25 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) ADZ27_13760 ENOG4108IJ7 Glycine betaine ADZ27_13765 ENOG4108HQS Glycine betaine ADZ27_13770 ENOG4105GIJ Glycine betaine ADZ27_13780 ENOG4108UMN azlc family ADZ27_13785 ENOG4105ZED uncharacterized protein ygaH ADZ27_13790 ENOG4105NTK Transcriptional repressor Mpra ADZ27_13795 ENOG4105CW7 secretion protein, HlyD family ADZ27_13800 ENOG4105C0R drug resistance transporter emrb qaca subfamily ADZ27_13815 ENOG4105W39 Membrane ADZ27_13820 ENOG4107VXZ Hydrolase ADZ27_13855 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) ADZ27_13860 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) ADZ27_13880 ENOG4107TH8 cina domain protein ADZ27_13885 ENOG4105CVE Lytic murein transglycosylase ADZ27_13890 ENOG410787A Pts system, glucitol sorbitol-specific ADZ27_13895 ENOG4105DZY Pts system, glucitol sorbitol-specific ADZ27_13900 ENOG4105VI0 Pts system, glucitol sorbitol-specific ADZ27_13905 ENOG4107QMF Sorbitol-6-phosphate dehydrogenase ADZ27_13910 ENOG4105J92 DNA-binding transcriptional activator GutM ADZ27_13915 ENOG410804X Transcriptional regulator ADZ27_13920 ENOG4105C2X Arabinose 5-phosphate isomerase ADZ27_13930 ENOG4108ESE uses NADH to detoxify nitric oxide (NO), protecting several 4Fe-4S NO-sensitive enzymes. Has at least 2 reductase partners, only one of which (NorW, flavorubredoxin reductase) has been identified. NO probably binds to the di-iron center ADZ27_13940 ENOG4105C8H hydrogenase maturation protein Hypf ADZ27_13945 ENOG4108RC0 Electron transport protein ADZ27_13950 ENOG4105DDV Transcriptional regulator (LacI family ADZ27_13955 ENOG4105C5Y PTS System ADZ27_13960 ENOG4105CS2 ec 3.2.1.21 ADZ27_13965 ENOG4108MG9 hydrogenase 3 maturation protease ADZ27_13970 ENOG4105I6X formate hydrogenlyase maturation ADZ27_13975 ENOG4105C47 NADH ubiquinone oxidoreductase 20 kda subunit ADZ27_13980 ENOG4108RG7 formate hydrogenlyase complex iron-sulfur subunit ADZ27_13985 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) ADZ27_13990 ENOG4107TDF Formate hydrogenlyase subunit 4 ADZ27_13995 ENOG4107R30 NADH dehydrogenase ADZ27_14000 ENOG4108MFN small subunit of hydrogenase-3, iron-sulfur protein (part of formate hydrogenlyase (FHL) complex) ADZ27_14010 ENOG4108VRC Formate hydrogenlyase regulatory protein hycA ADZ27_14015 ENOG410816D Probably plays a role in a hydrogenase nickel cofactor insertion step (By similarity) ADZ27_14020 ENOG4107RSS Hydrogenase accessory protein HypB ADZ27_14025 ENOG41083WG hydrogenase assembly chaperone ADZ27_14030 ENOG4105CQS hydrogenase expression formation protein HypD ADZ27_14035 ENOG4105C45 hydrogenase expression formation protein (HypE) ADZ27_14040 ENOG4108JUA Transcriptional regulator ADZ27_14045 ENOG4105VXR cytoplasmic protein ADZ27_14055 ENOG4105MEW serine threonine protein phosphatase ADZ27_14060 ENOG4105MVE transcriptional regulator ADZ27_14065 ENOG4105ZXK Dehydrogenase ADZ27_14070 ENOG4105G63 Type III effector Hrp-dependent ADZ27_14075 ENOG4105FB2 class II Aldolase ADZ27_14080 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) ADZ27_14085 ENOG4105C6Z Gluconate ADZ27_14090 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) ADZ27_14095 ENOG4108K5P (LipO)protein ADZ27_14130 ENOG4105N0Z inner membrane protein ygbE ADZ27_14150 ENOG4108MXK alkaline phosphatase isozyme conversion ADZ27_14155 ENOG4105PWE CRISPR-associated protein cas2 ADZ27_14160 ENOG4105TZK CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. May be involved in the integration of spacer DNA into the CRISPR cassette (By similarity) ADZ27_14165 ENOG4108Y7V CRISPR-associated protein, Cse3 family ADZ27_14170 ENOG4108VWQ crispr-associated protein ADZ27_14175 ENOG41060M0 Crispr-associated protein, cse4 family ADZ27_14180 ENOG41061HK CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA) ADZ27_14185 ENOG4105CYR Crispr-associated protein, cse1 family ADZ27_14190 ENOG4105DTT CRISPR-associated helicase, cas3 ADZ27_14205 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) ADZ27_14210 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase ADZ27_14215 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase ADZ27_14220 ENOG4105WQV ferredoxin-like protein ADZ27_14225 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator ADZ27_14230 ENOG4105YBM electron transfer flavoprotein subunit ygcQ ADZ27_14235 ENOG4106IKH Electron transfer flavoprotein ADZ27_14240 ENOG4105C54 Major Facilitator superfamily ADZ27_14245 ENOG4107R3A FAD linked oxidase domain protein ADZ27_14250 ENOG4105CHR reductase ADZ27_14255 ENOG4108ITV Inner membrane protein yqcE ADZ27_14260 ENOG4108CWB sugar kinase ygcE ADZ27_14265 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) ADZ27_14275 ENOG4105HA9 of methanol dehydrogenase type ADZ27_14290 ENOG4105DXN mazG family ADZ27_14295 ENOG4105MZG transcriptional modulator of maze toxin, mazf ADZ27_14300 ENOG4106A2Z transcriptional regulator antitoxin, MazE ADZ27_14305 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) ADZ27_14310 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) ADZ27_14315 ENOG4105BZU Histidine kinase ADZ27_14320 ENOG4105EQX glucarate dehydratase ADZ27_14325 ENOG4105EQX glucarate dehydratase ADZ27_14330 ENOG4105DJB Major Facilitator Superfamily ADZ27_14335 ENOG4105QDK Flavodoxin ADZ27_14340 ENOG4105DR9 pseudouridine synthase ADZ27_14345 ENOG4105WP7 tRNA pseudouridine synthase C ADZ27_14365 ENOG4105EWT decarboxylase family ADZ27_14370 ENOG4105C44 Serine transporter ADZ27_14375 ENOG4105EJQ L-serine dehydratase ADZ27_14385 ENOG4105C0A alcohol dehydrogenase ADZ27_14390 ENOG4107W7X Aldolase ADZ27_14395 ENOG4105EDR glucose galactose transporter ADZ27_14405 ENOG4105CMG Carbohydrate kinase ADZ27_14415 ENOG4107EDW L-fucose operon activator ADZ27_14425 ENOG4105M08 Membrane ADZ27_14430 ENOG4105ETT transcriptional Regulator, LysR family ADZ27_14435 ENOG4105M5B (LipO)protein ADZ27_14440 ENOG4105C9B Cysteine desulfurase ADZ27_14445 ENOG4105P9C Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity) ADZ27_14450 ENOG4105CUZ uba thif-type nad fad binding protein ADZ27_14455 ENOG4105CA3 membrane-bound lytic murein transglycosylase ADZ27_14475 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase ADZ27_14480 ENOG4107QZM n-acetylglutamate synthase ADZ27_14485 ENOG4107QYX exodeoxyribonuclease v alpha ADZ27_14490 ENOG4107QKA exodeoxyribonuclease V beta ADZ27_14495 ENOG4107QXK peptidase ADZ27_14500 ENOG4105DSY exodeoxyribonuclease V, gamma ADZ27_14505 ENOG4105RVB Prepilin peptidase dependent protein c ADZ27_14510 ENOG4105SEN Protein of unknown function (DUF2509) ADZ27_14515 ENOG4105JCS prepilin peptidase dependent protein ADZ27_14520 ENOG4105IPU prepilin peptidase dependent protein A ADZ27_14535 ENOG4108HRM phosphoenolpyruvate--protein phosphotransferase ADZ27_14560 ENOG4105EE5 Membrane protein terC ADZ27_14565 ENOG4105SUV lipoprotein YgdR ADZ27_14570 ENOG4105CPC Aldo Keto reductase ADZ27_14585 ENOG41060NJ transcriptional regulator ADZ27_14590 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) ADZ27_14595 ENOG4105RQF LysR family Transcriptional regulator ADZ27_14600 ENOG4105CG9 aspartate racemase ADZ27_14605 ENOG4107QNK )-transporter ADZ27_14610 ENOG4105CHR reductase ADZ27_14620 ENOG4105CHU acetyl-coa acetyltransferase ADZ27_14625 ENOG4108MHD transport protein ADZ27_14630 ENOG4105ISV protein with bipartite regulator domain ADZ27_14635 ENOG4108TC1 Transcriptional regulator ADZ27_14640 ENOG4105FV3 ADZ27_14660 ENOG4108YAB Invasion protein ADZ27_14700 ENOG4108MVM Transposase ADZ27_14705 ENOG4108ZQS transposase ADZ27_14715 ENOG4108T88 ADZ27_14725 ENOG4108K5P (LipO)protein ADZ27_14730 ENOG4105C7W Xanthine dehydrogenase ADZ27_14735 ENOG4108HR6 Dehydrogenase ADZ27_14740 ENOG4108UTP (2Fe-2S)-binding domain protein ADZ27_14745 ENOG4108JUB Transcriptional regulator ADZ27_14750 ENOG4105IW6 Carbamoyltransferase ADZ27_14755 ENOG4107RCH Diaminopropionate ammonia-lyase ADZ27_14760 ENOG4107S4Y M20 DapE family protein YgeY ADZ27_14770 ENOG4105C5B carbamate kinase ADZ27_14775 ENOG4107P0T Selenium-dependent molybdenum hydroxylase system protein, YqeB family ADZ27_14780 ENOG4105MJ6 selenium-dependent hydroxylase accessory protein YqeC ADZ27_14785 ENOG4105MFX 4-diphosphocytidyl-2c-methyl-d-erythritol synthase ADZ27_14790 ENOG4105BZ8 glutamate synthase ADZ27_14795 ENOG4107UUR Chlorohydrolase aminohydrolase ADZ27_14800 ENOG410873Y FAD binding domain in molybdopterin dehydrogenase ADZ27_14805 ENOG4105C7W Xanthine dehydrogenase ADZ27_14810 ENOG4105C2W permease ADZ27_14815 ENOG4107QUY Guanine deaminase ADZ27_14820 ENOG4105C7N Xanthine uracil vitamin C permease ADZ27_14825 ENOG4108R8B oxidoreductase Fe-S subunit ADZ27_14830 ENOG4105BZ8 glutamate synthase ADZ27_14840 ENOG4105C2W permease ADZ27_14855 ENOG4105CRK lysyL-tRNA synthetase ADZ27_14865 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) ADZ27_14870 ENOG4105T95 Thiol disulfide interChange protein ADZ27_14875 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) ADZ27_14880 ENOG41071R3 Low-potential electron donor to a number of redox enzymes (By similarity) ADZ27_14885 ENOG4108YDB Toxic component of a toxin-antitoxin (TA) module. Overexpression leads to growth arrest after 5 hours, with initial elongation of cells, followed by swelling. The toxic effects are abrogated by coexpression with antitoxin CptB. Interacts with cytoskeletal proteins FtsZ and MreB ADZ27_14890 ENOG4105Y75 tpr repeat protein ADZ27_14900 ENOG4108UT2 hemolysin iii ADZ27_14905 ENOG4105N5Z UPF0267 protein ADZ27_14910 ENOG4105CS2 ec 3.2.1.21 ADZ27_14915 ENOG4105CYX Short-chain dehydrogenase reductase Sdr ADZ27_14935 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family ADZ27_14940 ENOG4105D0A hydroxylase ADZ27_14945 ENOG4107RAQ aminopeptidase ADZ27_14960 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase ADZ27_14965 ENOG4108JQ1 Dehydrogenase ADZ27_14985 ENOG4105D5P Methylmalonyl-coA mutase ADZ27_14990 ENOG4105DJT lAO AO transport system ATPase ADZ27_14995 ENOG4108M7F enoyl-CoA hydratase isomerase ADZ27_15000 ENOG4105CYC Transferase ADZ27_15005 ENOG4105DEQ transcriptional regulator ADZ27_15010 ENOG4105MPN Membrane ADZ27_15015 ENOG4108ZUB Lysine exporter protein (Lyse ygga) ADZ27_15020 ENOG4105D64 Mechanosensitive ion channel ADZ27_15025 ENOG4105D2N Aldolase ADZ27_15040 ENOG4107Z1W Fructose transport system kinase ADZ27_15045 ENOG4108R4K DNA-binding, transcriptional regulator ADZ27_15050 ENOG4108Q8A Fructose-1,6-bisphosphatase ADZ27_15055 ENOG4105DXH Alcohol dehydrogenase zinc-binding domain protein ADZ27_15060 ENOG4105CTS PTS system mannitol-specific ADZ27_15065 ENOG4108X7Y Mannitol-specific cryptic phosphotransferase enzyme iia ADZ27_15070 ENOG4105CV1 Transketolase (EC 2.2.1.1) ADZ27_15075 ENOG4108K0D peptidase, M48 ADZ27_15085 ENOG4105DP5 Catalyzes the biosynthesis of agmatine from arginine (By similarity) ADZ27_15110 ENOG4107QNK )-transporter ADZ27_15120 ENOG4105RWS endonuclease I ADZ27_15125 ENOG4105QF0 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) ADZ27_15130 ENOG4105D7Z glutathione synthase ADZ27_15145 ENOG4105CZX twitching motility protein ADZ27_15150 ENOG4105DFA alanine racemase domain protein ADZ27_15155 ENOG4108VIA integral membrane protein ADZ27_15165 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) ADZ27_15170 ENOG4105CSA Coproporphyrinogen iii oxidase ADZ27_15175 ENOG4106MH3 alpha helix chain ADZ27_15180 ENOG4105HDK L-asparaginase ADZ27_15185 ENOG4105K33 Periplasmic Protein ADZ27_15195 ENOG41090ED Protein with unknown function (DUF469) ADZ27_15205 ENOG4105CEN a g-specific adenine glycosylase ADZ27_15220 ENOG4105EAA nucleoside ADZ27_15225 ENOG4105CXN decarboxylase ADZ27_15230 ENOG4108UQV Membrane ADZ27_15240 ENOG4105U1E general secretion pathway protein M ADZ27_15250 ENOG4108XKW General secretion pathway protein C ADZ27_15255 ENOG410765S (LipO)protein ADZ27_15260 ENOG4105EHH Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue (By similarity) ADZ27_15265 ENOG4105F88 accessory colonization factor AcfD ADZ27_15275 ENOG4105DAA L-lactate ADZ27_15280 ENOG4107QP3 malate synthase g ADZ27_15285 ENOG4108ZJF Glcg protein ADZ27_15290 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) ADZ27_15295 ENOG4105EU8 FAD linked oxidase domain protein ADZ27_15300 ENOG4105CQB FAD linked oxidase domain protein ADZ27_15305 ENOG4108KWP DNA-binding transcriptional regulator GlcC ADZ27_15315 ENOG4105F2I Transposase ADZ27_15320 ENOG4108S55 polysaccharide biosynthesis protein ADZ27_15325 ENOG4106FPV ATP-binding protein YghR ADZ27_15330 ENOG4108NDC ATP-binding protein yghS ADZ27_15335 ENOG4108GH0 ATP-binding protein yghT ADZ27_15340 ENOG4105CJ3 phosphate transporter ADZ27_15345 ENOG4106032 Glutathionylspermidine synthase ADZ27_15350 ENOG4105CYM Glutathione S-transferase ADZ27_15355 ENOG41082MF Hydrogenase assembly chaperone hypC hupF ADZ27_15360 ENOG4105WMM Probably plays a role in a hydrogenase nickel cofactor insertion step (By similarity) ADZ27_15365 ENOG4108WGS hydrogenase 2-specific chaperone ADZ27_15370 ENOG4108USZ hydrogenase ADZ27_15375 ENOG4105DPX Hydrogenase, large subunit ADZ27_15380 ENOG4105CJ5 hydrogenase 2 b cytochrome subunit ADZ27_15385 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein ADZ27_15390 ENOG4105E3S small subunit ADZ27_15400 ENOG410900S Protein of unknown function (DUF2623) ADZ27_15410 ENOG4105CPC Aldo Keto reductase ADZ27_15420 ENOG4105CYX Short-chain dehydrogenase reductase Sdr ADZ27_15425 ENOG4108ZZF transport protein (ExbD) ADZ27_15430 ENOG4105CWK Biopolymer transport protein, ExbB ADZ27_15440 ENOG4105C28 cystathionine ADZ27_15445 ENOG4108K81 inner membrane protein YghB ADZ27_15450 ENOG4105CF7 AraC family transcriptional regulator ADZ27_15460 ENOG4108I6A alcohol dehydrogenase ADZ27_15465 ENOG4105CV8 reductase ADZ27_15470 ENOG4105ZKC Conserved Protein ADZ27_15480 ENOG4105CCT upf0313 protein ADZ27_15490 ENOG4107S7E 1-acyl-sn-glycerol-3-phosphate acyltransferase ADZ27_15495 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) ADZ27_15500 ENOG4108J59 Extracellular solute-binding protein, family 5 ADZ27_15505 ENOG4105WJ3 XRE family Transcriptional regulator ADZ27_15510 ENOG4105RT5 Toxic component of a toxin-antitoxin (TA) module. An mRNA interferase which has been reported to be translation- independent (PubMed 19690171, PubMed 19943910) and translation- dependent (PubMed 20041169). Cleavage has been reported to occur on either side of G in the sequence GCU (PubMed 19690171) but also after C in GC(A U) sequences (PubMed 19943910). There are only 14 genes in E.coli W3110 (and probably also MG1655) that do not have a GCU sequence and thus are resistant to the mRNA interferase activity. Overexpression causes cessation of cell growth and inhibits cell proliferation via inhibition of translation as well as increasing persister cell formation ADZ27_15515 ENOG4105F4I Transcriptional regulator ADZ27_15520 ENOG4105H4F exported protein ADZ27_15525 ENOG4105XJC Two component transcriptional regulator (Winged helix family ADZ27_15530 ENOG4105DHQ Histidine kinase ADZ27_15535 ENOG4107DEU Inner membrane protein YgiZ ADZ27_15540 ENOG4105NF4 modulator of drug activity ADZ27_15545 ENOG4105VRH Antibiotic biosynthesis monooxygenase ADZ27_15550 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) ADZ27_15555 ENOG4105IPS esterase ADZ27_15560 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) ADZ27_15565 ENOG4108SX3 cytoplasmic protein ADZ27_15570 ENOG41087AY ADP-Ribose pyrophosphatase ADZ27_15575 ENOG4105DFG type I secretion outer membrane protein ADZ27_15590 ENOG4106032 Glutathionylspermidine synthase ADZ27_15595 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b ADZ27_15615 ENOG4105W0Z cytoplasmic protein ADZ27_15620 ENOG4105H8W Fimbrial protein ADZ27_15625 ENOG4108ZQS transposase ADZ27_15630 ENOG4108MVM Transposase ADZ27_15640 ENOG4108TTM chaperone ADZ27_15645 ENOG4108MY7 Fimbrial ADZ27_15655 ENOG4105PV3 Inner membrane protein yqiJ ADZ27_15660 ENOG4107S78 Band 7 protein ADZ27_15685 ENOG4105I7R Adenylate cyclase ADZ27_15695 ENOG4106MWK domain protein ADZ27_15705 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) ADZ27_15710 ENOG4107ZVW dihydroneopterin aldolase ADZ27_15720 ENOG4105EJC lysr family transcriptional regulator ADZ27_15725 ENOG4106DSS Tartrate dehydratase subunit alpha ADZ27_15735 ENOG4107QPK )-transporter ADZ27_15745 ENOG4105VCC 30S ribosomal protein S21 ADZ27_15750 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) ADZ27_15755 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) ADZ27_15770 ENOG4105Q26 Siderophore-interacting protein ADZ27_15775 ENOG4105NTW Transcriptional regulator ADZ27_15780 ENOG4107RHT methyl-accepting chemotaxis sensory transducer with Pas Pac sensor ADZ27_15790 ENOG4108Y51 tRNA-binding protein ADZ27_15795 ENOG4105CQ4 Transcriptional regulator ADZ27_15800 ENOG4105CNT hydrolase family 2 ADZ27_15805 ENOG4105FK9 beta-D-galactosidase beta subunit ADZ27_15810 ENOG4105E5D amino acid ADZ27_15815 ENOG4107W6W Conserved Protein ADZ27_15820 ENOG4107WCA isomerase ADZ27_15825 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase ADZ27_15830 ENOG4108Z3N Transcriptional regulator ADZ27_15835 ENOG4105R48 this blockage is overcome by subsequent expression of antitoxin HigA. Overexpression causes cleavage of a number of mRNAs in a translation-dependent fashion, suggesting this is an mRNA interferase ADZ27_15845 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) ADZ27_15850 ENOG4108VKG metal-dependent hydrolase ADZ27_15855 ENOG4108UB4 uncharacterized protein ygjQ ADZ27_15860 ENOG4105EE0 oxidoreductase ADZ27_15865 ENOG4105DU1 integral membrane protein, terc ADZ27_15870 ENOG4107QV7 Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system) (By similarity) ADZ27_15875 ENOG4105P66 Membrane ADZ27_15880 ENOG4105CTX dehydratase ADZ27_15890 ENOG4105DPW Major facilitator superfamily MFS_1 ADZ27_15895 ENOG4107YCY Transcriptional regulator ADZ27_15900 ENOG4106W5V Membrane ADZ27_15905 ENOG4105IYR Modulates the activity of the EnvZ OmpR two-component regulatory system, probably by directly modulating EnvZ enzymatic activity and increasing stability of phosphorylated OmpR (By similarity) ADZ27_15910 ENOG4105WAY exported protein ADZ27_15915 ENOG4105NE1 Conserved Protein ADZ27_15920 ENOG41090KG Inner membrane protein YqjE ADZ27_15925 ENOG4105YJD ADZ27_15930 ENOG4108VBZ doxx family ADZ27_15935 ENOG4105CHF Glutathione S-transferase ADZ27_15940 ENOG4105KAF membrAne ADZ27_15945 ENOG4105KAF membrAne ADZ27_15950 ENOG4105CWB LysR family transcriptional Regulator ADZ27_15955 ENOG4108CNN domain protein ADZ27_15960 ENOG4106D80 Uncharacterized protein YhaL ADZ27_15970 ENOG4105C44 Serine transporter ADZ27_15975 ENOG4105EJQ L-serine dehydratase ADZ27_15980 ENOG4105KME endoribonuclease L-psp ADZ27_15985 ENOG4105C6N Formate acetyltransferase ADZ27_15990 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) ADZ27_16000 ENOG4105C7B Threonine dehydratase ADZ27_16005 ENOG410811B TRANSCRIPTIONal ADZ27_16025 ENOG4105BZW Glycerate kinase ADZ27_16030 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase ADZ27_16040 ENOG4105DJB Major Facilitator Superfamily ADZ27_16045 ENOG4105CTX dehydratase ADZ27_16050 ENOG4105ZEG Suppressor protein ADZ27_16055 ENOG4108R8Z these effects are overcome by concomitant expression of antitoxin SohA (PrlF). Massive overexpression is toxic. Unlike most other characterized TA systems degrades rRNA, and co-folding of the proteins is necessary in vitro for inhibition of the RNase activity. It is not known if it has any sequence-specificity. Acts as a transcription factor. The YhaV PrlF complex binds the prlF-yhaV operon, probably negatively regulating its expression ADZ27_16060 ENOG4105E98 transcriptional regulator DeoR family ADZ27_16070 ENOG4108RG5 PTS system N-acetylgalactosamine-specific transporter subunit IIB ADZ27_16080 ENOG4105CE4 GlcNAc 6-P deacetylase ADZ27_16085 ENOG4105E70 isomerase ADZ27_16095 ENOG4108UZY PTS System ADZ27_16100 ENOG4105ETZ PTS System ADZ27_16105 ENOG4105F3R pts system mannose fructose sorbose family iid ADZ27_16110 ENOG4106HBN Galactosamine-6-phosphate isomerase ADZ27_16115 ENOG4105Q10 Fimbrial-like protein ADZ27_16120 ENOG4108VCD Chaperone ADZ27_16125 ENOG4105CW0 outer membrane usher protein ADZ27_16130 ENOG4105I74 Fimbrial protein ADZ27_16135 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) ADZ27_16140 ENOG4105E1C Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1A (PBP1a) (By similarity) ADZ27_16150 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) ADZ27_16155 ENOG4105W4M Transport-associated protein ADZ27_16160 ENOG4107S21 permease ADZ27_16165 ENOG4105K4T epimerase ADZ27_16170 ENOG4107R7Y intracellular protease Pfpi family ADZ27_16185 ENOG4108YYD acetyltransferase ADZ27_16190 ENOG4105XPQ lipid carrier protein ADZ27_16195 ENOG4105CFP Peptidase U32 ADZ27_16200 ENOG4106RZ4 Peptidase U32 ADZ27_16205 ENOG4105DEN Luciferase family ADZ27_16210 ENOG4105CIC tryptophan-specific transport protein ADZ27_16220 ENOG4105C1J atp-dependent rna helicase ADZ27_16225 ENOG4105RT1 May be involved in cell division (By similarity) ADZ27_16240 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) ADZ27_16255 ENOG4105CHV Transcription elongation factor NusA ADZ27_16275 ENOG4105DIJ Phosphoethanolamine transferase ADZ27_16295 ENOG4105EEI dihydropteroate synthase ADZ27_16300 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) ADZ27_16305 ENOG4105F7M Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit (By similarity) ADZ27_16310 ENOG4105HBR Rna-binding protein ADZ27_16315 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) ADZ27_16320 ENOG4106HRJ d-alanyl-d-alanine carboxypeptidase ADZ27_16325 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control ADZ27_16330 ENOG4105QYV Membrane ADZ27_16345 ENOG4105EAH synthase ADZ27_16350 ENOG4105HVQ Regulatory factor of maltose metabolism ADZ27_16360 ENOG4105VFK BolA family ADZ27_16365 ENOG4105UE2 Part of the ABC transporter complex MlaFEDB that actively prevents phospholipid accumulation at the cell surface. Probably maintains lipid asymmetry in the outer membrane by retrograde trafficking of phospholipids from the outer membrane to the inner membrane ADZ27_16370 ENOG4105E3I toluene tolerance ADZ27_16375 ENOG4107PE3 Mammalian cell entry related domain protein ADZ27_16380 ENOG4105CY3 ABC transporter, permease ADZ27_16385 ENOG4105DHJ ABC, transporter ADZ27_16390 ENOG4105FEU K -dependent Na -Ca exchanger ADZ27_16395 ENOG4105C2X Arabinose 5-phosphate isomerase ADZ27_16400 ENOG4108Z4R 3-deoxy-d-manno-octulosonate 8-phosphate phosphatase ADZ27_16405 ENOG4108P1K Required for the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane (By similarity) ADZ27_16410 ENOG4105WI0 lipopolysaccharide transport periplasmic protein lptA ADZ27_16415 ENOG4108IUZ ABC transporter ADZ27_16420 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) ADZ27_16425 ENOG41080QH sigma 54 modulation protein ribosomal protein S30EA ADZ27_16430 ENOG4107RM2 PTS IIA-like nitrogen-regulatory protein PtsN ADZ27_16440 ENOG41080Z8 PHOSPHOCARRIER protein ADZ27_16445 ENOG4108NIH transferase activity, transferring phosphorus-containing groups ADZ27_16455 ENOG4108556 Isoprenoid biosynthesis protein with amidotransferase-like domain ADZ27_16460 ENOG4105BZU Histidine kinase ADZ27_16465 ENOG4105N5T Radical SAM Protein ADZ27_16470 ENOG4105CBC glutamate synthase ADZ27_16475 ENOG4105BZ8 glutamate synthase ADZ27_16480 ENOG4106AJS Involved in induction of the so-called NTR enzymes in response to nitrogen deprivation, as well as in glutamate biosynthesis. May mediate the glutamate-dependent repression of the GLT operon ADZ27_16485 ENOG4108S1B Periplasmic chaperone protein ADZ27_16490 ENOG4105E6S usher protein( ADZ27_16500 ENOG4105F2I Transposase ADZ27_16510 ENOG4105UMR response to DNA damage stimulus ADZ27_16515 ENOG4105DFS Conserved Protein ADZ27_16520 ENOG4108R66 Conserved Protein ADZ27_16550 ENOG4105CEE C4-dicarboxylate transporter ADZ27_16555 ENOG4105KB2 stringent starvation protein b ADZ27_16560 ENOG4107MKT Stringent starvation protein a ADZ27_16565 ENOG4108UJD 30S ribosomal protein S9 ADZ27_16575 ENOG4105D6Z AFG1 family ATPase ADZ27_16580 ENOG4108W2Q Cytochrome d ubiquinol oxidase subunit III ADZ27_16585 ENOG4105C0H protease ADZ27_16590 ENOG4105C0H protease ADZ27_16605 ENOG4105RID UPF0379 protein yhcN ADZ27_16610 ENOG4105UNR (Barnase) inhibitor ADZ27_16630 ENOG4105CR8 Transcriptional regulator ADZ27_16635 ENOG4105D1U peptidase U62 modulator of DNA gyrase ADZ27_16640 ENOG4105QD6 exported protein ADZ27_16645 ENOG4105C03 ribonuclease ADZ27_16650 ENOG4108Z03 MAF-like protein ADZ27_16655 ENOG4105VQ7 Rod shape-determining protein MreD ADZ27_16660 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) ADZ27_16665 ENOG4105DFF Rod shape-determining protein mreb ADZ27_16675 ENOG41062P1 Diguanylate cyclase phosphodiesterase ADZ27_16680 ENOG4105D3Z quinone oxidoreductase, yhdh yhfp family ADZ27_16700 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein ADZ27_16705 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase ADZ27_16710 ENOG4105RG0 Membrane ADZ27_16715 ENOG4108IA2 Sodium pantothenate symporter ADZ27_16725 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) ADZ27_16730 ENOG4105VY0 Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters (By similarity) ADZ27_16735 ENOG4105CEC DNA methylase N-4 N-6 ADZ27_16740 ENOG41061ME transport protein ADZ27_16745 ENOG4108XG4 DNA-binding transcriptional regulator ADZ27_16750 ENOG4105C1P efflux transporter, rnd family, mfp subunit ADZ27_16755 ENOG4105BZS acriflavin resistance protein ADZ27_16760 ENOG4105XCM membrane LIPOPROTEIN ADZ27_16775 ENOG4105EZ7 amino acid ABC transporter ADZ27_16780 ENOG4105DRP amino acid AbC transporter ADZ27_16785 ENOG4105CDA abc transporter atp-binding protein ADZ27_16825 ENOG4108Z0R Transferase ADZ27_16830 ENOG4105SG3 Protein of unknown function (DUF1488) ADZ27_16840 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) ADZ27_16845 ENOG4108WI1 Dna topoisomerase ADZ27_16855 ENOG4105C79 DNA protecting protein DprA ADZ27_16875 ENOG4105C1A potassium transporter peripheral membrane ADZ27_16885 ENOG4105VCN Rescues the ribosomes stalled at the 3' end of non-stop mRNAs. May induce hydrolysis of the ribosome-bound peptidyl-tRNA. This activity is crucial when the stalled ribosome can not be rescued by the SsrA(tmRNA)-SmpB quality control system ADZ27_16890 ENOG4105W1Y Transcriptional regulator ADZ27_16895 ENOG4105VTS DnaJ-like, subfamily C ADZ27_16905 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) ADZ27_16910 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) ADZ27_16920 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits ADZ27_16925 ENOG41067V7 50S ribosomal protein L36 ADZ27_16930 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) ADZ27_16945 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) ADZ27_16950 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) ADZ27_16960 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) ADZ27_16975 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) ADZ27_16985 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal ADZ27_16995 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) ADZ27_17000 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) ADZ27_17005 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) ADZ27_17010 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) ADZ27_17020 ENOG41080KG One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) ADZ27_17025 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) ADZ27_17040 ENOG4107ACA Calcium-binding protein required for initiation of chromosome replication ADZ27_17045 ENOG410899B May play a regulatory role under conditions of derepressed gsp gene expression ADZ27_17050 ENOG4107KSE General secretion pathway protein C ADZ27_17055 ENOG4105GVR general secretion pathway protein D ADZ27_17060 ENOG4107QHF type ii secretion system protein e ADZ27_17065 ENOG4105D7Q type ii secretion system ADZ27_17070 ENOG4108VAU general secretion pathway protein G ADZ27_17075 ENOG41069X0 general secretion pathway protein h ADZ27_17090 ENOG4105R04 type II secretion system protein K ADZ27_17095 ENOG41063JA Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins (By similarity) ADZ27_17105 ENOG4105EHH Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue (By similarity) ADZ27_17110 ENOG4108UQY Iron-storage protein ADZ27_17115 ENOG4105W53 bacterioferritin-associated ferredoxin ADZ27_17120 ENOG4108NNZ chitinase ADZ27_17160 ENOG4105WWK YheO domain protein ADZ27_17165 ENOG4108V1T peptidylprolyl cis-trans isomerase ADZ27_17175 ENOG4108YZY peptidylprolyl cis-trans isomerase ADZ27_17180 ENOG4105VKU nucleicacid-binding protein ADZ27_17195 ENOG4105C5H ABC transporter ADZ27_17200 ENOG4105DNZ Alpha Beta Hydrolase ADZ27_17210 ENOG4105CJE phosphoribulokinase (EC 2.7.1.19) ADZ27_17215 ENOG4108UKZ OsmC family ADZ27_17225 ENOG4107RYR Transcriptional regulator, Crp Fnr family ADZ27_17230 ENOG410613R integral membrane protein, YccS YhfK family ADZ27_17235 ENOG4105C8Y Acetylornithine aminotransferase ADZ27_17240 ENOG4105DDQ anthranilate synthase ADZ27_17245 ENOG4105MZU cell filamentation protein ADZ27_17250 ENOG4106195 uncharacterized protein yhfG ADZ27_17255 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) ADZ27_17265 ENOG4107QZF nitrite reductase NADPH large subunit ADZ27_17270 ENOG4105WZK nitrite reductase NADPH small subunit ADZ27_17275 ENOG4107V9H nitrite transporter ADZ27_17285 ENOG4105VYH ADZ27_17290 ENOG4107QHQ amino acid ADZ27_17295 ENOG4107R1S catalyzes the conversion of fructoselysine 6-phosphate to glucose 6-phosphate and lysine ADZ27_17300 ENOG4107Y0V Not clear, may be involved in an isomerization step ADZ27_17305 ENOG4108KPW sugar kinase ADZ27_17310 ENOG4105FDP GntR family transcriptional regulator ADZ27_17315 ENOG4106PKC pyridoxal phosphate binding ADZ27_17320 ENOG4106M0N transport system permease protein ADZ27_17325 ENOG4105MUZ Protein of unknown function DUF2620 ADZ27_17330 ENOG41080QX K07048 phosphotriesterase-related protein ADZ27_17335 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) ADZ27_17340 ENOG4108626 Racemase ADZ27_17345 ENOG4105RMW regulation of transcription, DNA-dependent ADZ27_17350 ENOG4108M21 ADZ27_17355 ENOG4105C31 Tryptophanyl-tRNA synthetase ADZ27_17360 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) ADZ27_17365 ENOG4105DJV ribulose-phosphate 3-epimerase ADZ27_17370 ENOG4105DFE Dna adenine methylase ADZ27_17375 ENOG4105EGB membrane protein DamX ADZ27_17390 ENOG4105E4G Type IV pilus ADZ27_17395 ENOG4105ITY Required for the use of extracellular DNA as a nutrient ADZ27_17400 ENOG4105XPX DNA utilization protein HofO ADZ27_17405 ENOG41065NF Fimbrial assembly family protein ADZ27_17410 ENOG4108U1Q Pilus assembly protein ADZ27_17415 ENOG4108JQC penicillin-binding protein 1A ADZ27_17420 ENOG4107RK2 ADP-ribose diphosphatase NudE ADZ27_17425 ENOG4105DQY intracellular growth attenuator ADZ27_17430 ENOG4107Y3D HAD-superfamily hydrolase subfamily IA variant 3 ADZ27_17435 ENOG4105VEJ Heat shock protein ADZ27_17445 ENOG4108MAJ Membrane ADZ27_17460 ENOG4105E0F Histidine kinase ADZ27_17465 ENOG4105DPZ Two component transcriptional regulator (Winged helix family ADZ27_17470 ENOG4108RRZ Transcription elongation factor GreB ADZ27_17475 ENOG4105BZM domain protein ADZ27_17480 ENOG4105XFK Ferrous iron transport protein A ADZ27_17485 ENOG4105CE1 Ferrous iron transport protein b ADZ27_17495 ENOG4105DNE Transposase ADZ27_17505 ENOG4105MJ2 Competence protein ADZ27_17515 ENOG4105C6Z Gluconate ADZ27_17520 ENOG4107RTM 4-alpha-glucanotransferase (EC 2.4.1.25) ADZ27_17525 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) ADZ27_17540 ENOG4105E0Y RtcB Protein ADZ27_17545 ENOG4105CYB regulatoR ADZ27_17550 ENOG4105E98 transcriptional regulator DeoR family ADZ27_17565 ENOG4105C6V Glycerol-3-phosphate dehydrogenase ADZ27_17575 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) ADZ27_17600 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) ADZ27_17605 ENOG41076UM multiple antibiotic resistance (MarC)-related protein ADZ27_17610 ENOG4105C6Z Gluconate ADZ27_17615 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family ADZ27_17620 ENOG4105DIQ Transcriptional regulator ADZ27_17625 ENOG4105C2I pirin domain protein ADZ27_17630 ENOG4105D9R oxidoreductase ADZ27_17635 ENOG4105WCN acetyltransferase ADZ27_17640 ENOG4105GMB type VI secretion system effector, hcp1 family ADZ27_17655 ENOG4106FA4 ADZ27_17660 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) ADZ27_17665 ENOG4105WC8 Conserved Protein ADZ27_17670 ENOG4107T6V glycerophosphoryl diester phosphodiesterase ADZ27_17675 ENOG4108IJ9 (ABC) transporter ADZ27_17680 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component ADZ27_17685 ENOG4105E4X binding-protein-dependent transport systems inner membrane Component ADZ27_17690 ENOG4105BZ7 extracellular solute-binding protein family 1 ADZ27_17700 ENOG4108IV0 ABC, transporter ADZ27_17705 ENOG4105C0Z ABC transporter ADZ27_17710 ENOG4105CF8 branched-chain amino acid ABC transporter, permease ADZ27_17715 ENOG4105C32 Amino acid ABC transporter (Permease) ADZ27_17720 ENOG4105CP9 extracellular ligand-binding receptor ADZ27_17725 ENOG4105U59 -acetyltransferase ADZ27_17735 ENOG4105CP9 extracellular ligand-binding receptor ADZ27_17740 ENOG4105DEK Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) ADZ27_17745 ENOG4105CRP Part of the ABC transporter FtsEX involved in ADZ27_17750 ENOG4105CAK Cell division ATP-binding protein ftsE ADZ27_17755 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) ADZ27_17760 ENOG4106H78 methyltransferase ADZ27_17765 ENOG4105MG3 Membrane ADZ27_17775 ENOG4107FS9 Membrane ADZ27_17780 ENOG4105C59 p-type ATPase ADZ27_17790 ENOG4105EX9 Membrane ADZ27_17795 ENOG4108W1V Lipoprotein ADZ27_17800 ENOG4105F9N Major Facilitator Superfamily ADZ27_17805 ENOG4105DSF transport protein ADZ27_17810 ENOG4107YAK holo-(acyl carrier protein) synthase 2 ADZ27_17815 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein ADZ27_17820 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component ADZ27_17825 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component ADZ27_17830 ENOG4106665 Part of the ABC transporter complex NikABCDE involved in nickel import. Responsible for energy coupling to the transport system (By similarity) ADZ27_17835 ENOG4105EFJ Part of the ABC transporter complex NikABCDE involved in nickel import. Responsible for energy coupling to the transport system (By similarity) ADZ27_17845 ENOG4105CNA YD repeat protein ADZ27_17860 ENOG410600T transposase ADZ27_17865 ENOG4105CMI transporter ADZ27_17870 ENOG4105CJ1 ABC, transporter ADZ27_17875 ENOG4105D0S secretion protein (HlyD ADZ27_17900 ENOG4107UNS conserved inner membrane protein ADZ27_17905 ENOG4105CBX hi0933 family ADZ27_17910 ENOG4105CJ3 phosphate transporter ADZ27_17920 ENOG4108M6U Universal stress protein A ADZ27_17925 ENOG4105DUX Transporter ADZ27_17930 ENOG4105FFN Specifically methylates the guanosine in position 1516 of 16S rRNA (By similarity) ADZ27_17935 ENOG4105DGW oligopeptidase A ADZ27_17940 ENOG4105D6S protein involved in catabolism of external DNA ADZ27_17945 ENOG4105DC8 reductase ADZ27_17960 ENOG4105KBH arsR family transcriptional regulator ADZ27_17965 ENOG4107R5R arsenical pump membrane protein ADZ27_17970 ENOG4105K89 arsenate reductase ADZ27_17980 ENOG4105F2I Transposase ADZ27_17990 ENOG4105Y4Z Outer Membrane Lipoprotein ADZ27_18000 ENOG4105KT7 mgtC SapB transporter ADZ27_18005 ENOG4105XXV Acid-resistance protein ADZ27_18010 ENOG41060V2 Acid-resistance protein ADZ27_18015 ENOG4108YK4 Acid-resistance membrane protein ADZ27_18020 ENOG4106WJ0 Regulates the expression of several genes involved in acid resistance. Required for the expression of gadA and gadBC, among others, regardless of media or growth conditions. Binds directly to the 20 bp GAD box found in the control regions of both loci ADZ27_18030 ENOG4105C1P efflux transporter, rnd family, mfp subunit ADZ27_18035 ENOG4105BZS acriflavin resistance protein ADZ27_18040 ENOG4105D3F AraC Family Transcriptional Regulator ADZ27_18045 ENOG4108NKV transcriptional regulator ADZ27_18050 ENOG4105CVK Glutamate decarboxylase ADZ27_18055 ENOG4105CA0 peroxidase ADZ27_18060 ENOG4105E53 ec 3.2.1.28 ADZ27_18065 ENOG4106S2D Transcriptional regulator ADZ27_18070 ENOG4105CBN LysR family transcriptional regulator ADZ27_18075 ENOG4107H3J ribonuclease ADZ27_18080 ENOG4105CSH Transporter ADZ27_18085 ENOG4105CMB EAL domain-containing protein ADZ27_18095 ENOG4107SS6 2-dehydro-3-deoxygluconokinase ADZ27_18100 ENOG4105CS0 peptidase ADZ27_18110 ENOG4105BZU Histidine kinase ADZ27_18115 ENOG4105EJG cellulose synthase ADZ27_18120 ENOG4105K2Z endo-1,4-d-glucanase (EC 3.2.1.4) ADZ27_18125 ENOG4107EEX Cellulose synthase regulator protein ADZ27_18130 ENOG4107QZ7 Cellulose synthase catalytic subunit ADZ27_18140 ENOG410661M cytoplasmic protein ADZ27_18145 ENOG4105U74 cellulose biosynthesis protein BcsE ADZ27_18150 ENOG4105WQA Cellulose biosynthesis protein BcsF ADZ27_18155 ENOG4105D1V cellulose synthase operon protein YhjU ADZ27_18170 ENOG4105C44 Serine transporter ADZ27_18175 ENOG4108JQ7 (ABC) transporter ADZ27_18180 ENOG4105C3U ABC transporter ADZ27_18185 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component ADZ27_18190 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component ADZ27_18200 ENOG4105DEF Extracellular solute-binding protein, family 5 ADZ27_18215 ENOG4105DIJ Phosphoethanolamine transferase ADZ27_18220 ENOG4105FCD Major Facilitator ADZ27_18225 ENOG4105EAX Putative lipase ADZ27_18230 ENOG4108R3E Dna-3-methyladenine glycosylase i ADZ27_18235 ENOG4105HNP -acetyltransferase ADZ27_18240 ENOG4107QY8 reductase ADZ27_18245 ENOG4108ZG0 Ompa motb domain protein ADZ27_18255 ENOG4106JH6 (LipO)protein ADZ27_18260 ENOG4105MVF Transcriptional regulator ADZ27_18265 ENOG4105VEQ Cold shock protein ADZ27_18270 ENOG41060TC Hok gef cell toxic protein ADZ27_18275 ENOG410698F IS150 protein InsA ADZ27_18280 ENOG4105DQ6 Transposase ADZ27_18290 ENOG4108HMW glycyl-tRNA synthetase, alpha subunit ADZ27_18295 ENOG4105RGS lipoprotein ysaB ADZ27_18300 ENOG4105MEV Acyl-transferase ADZ27_18305 ENOG4108Z12 YiaAB two helix domain-containing protein ADZ27_18310 ENOG410688U Inner membrane protein yiaB ADZ27_18315 ENOG4105CMG Carbohydrate kinase ADZ27_18325 ENOG4105DFW ABC transporter ADZ27_18330 ENOG4105C2J ABC transporter ADZ27_18335 ENOG4107RNG ABC transporter ADZ27_18340 ENOG4105T16 Transcriptional regulator (AraC family) ADZ27_18345 ENOG4108UR8 BAX protein ADZ27_18350 ENOG4107T9C Alpha amylase catalytic region ADZ27_18355 ENOG4105JKW Valine--pyruvate aminotransferase ADZ27_18365 ENOG4108XIB electron transport protein ysaA ADZ27_18370 ENOG4105J4Q Transcriptional regulator ADZ27_18380 ENOG4108R66 Conserved Protein ADZ27_18385 ENOG4105XDZ Tripartite ATP-independent periplasmic transporter ADZ27_18390 ENOG4105CG6 trap dicarboxylate transporter dctm subunit ADZ27_18395 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit ADZ27_18400 ENOG4105CMG Carbohydrate kinase ADZ27_18405 ENOG4105H6Q decarboxylase ADZ27_18410 ENOG41064BZ L-xylulose 5-phosphate 3-epimerase ADZ27_18415 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase ADZ27_18420 ENOG4105GNX MltA-interacting MipA family protein ADZ27_18425 ENOG4108Q2M Transcriptional regulator ADZ27_18430 ENOG4105EFX secretion protein, HlyD family ADZ27_18435 ENOG4105KK7 inner membrane protein YiaW ADZ27_18445 ENOG4105C26 Dehydrogenase ADZ27_18450 ENOG4105C0A alcohol dehydrogenase ADZ27_18455 ENOG4105EM7 Selenocysteine-specific translation elongation factor ADZ27_18465 ENOG4108U78 Glutathione S-transferase ADZ27_18470 ENOG4105CNA YD repeat protein ADZ27_18475 ENOG4105NUP lyase containing HEAT-repeat ADZ27_18495 ENOG4105EFX secretion protein, HlyD family ADZ27_18500 ENOG4105FP6 Protein of unknown function (DUF3302) ADZ27_18505 ENOG4105CTS PTS system mannitol-specific ADZ27_18515 ENOG4105E61 Mannitol repressor protein ADZ27_18525 ENOG4108YYI Protein of unknown function (DUF2810) ADZ27_18530 ENOG4105DAA L-lactate ADZ27_18535 ENOG41073TP transcriptional regulator ADZ27_18545 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) ADZ27_18550 ENOG4105D7W serine acetyltransferase ADZ27_18565 ENOG4105VW4 glutaredoxin 3 ADZ27_18570 ENOG4107YZP Rhodanese domain protein ADZ27_18575 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) ADZ27_18580 ENOG41063SB peptidase ADZ27_18585 ENOG4105PXI polysaccharide deacetylase ADZ27_18590 ENOG4105K64 Glycosyl transferase, family 2 ADZ27_18600 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) ADZ27_18605 ENOG4108SEH involved in lipopolysaccharide biosynthesis ADZ27_18615 ENOG4105XA0 heptosyltransferase ii ADZ27_18620 ENOG4105D16 lipopolysaccharide heptosyltransferase i ADZ27_18625 ENOG41068PG O-Antigen polymerase ADZ27_18630 ENOG4108XNZ glycosyl transferase ADZ27_18635 ENOG4108QD8 lipopolysaccharide core biosynthesis protein ADZ27_18640 ENOG4108PDR lipopolysaccharide core biosynthesis protein ADZ27_18645 ENOG4105X1N Glycosyl transferase family 8 ADZ27_18650 ENOG4106AH0 Glycosyl Transferase ADZ27_18655 ENOG4107XU6 Glycosyl transferase (Group 1 ADZ27_18660 ENOG410650X lipopolysaccharide core region biosynthetic process ADZ27_18665 ENOG4107543 (lipo)polysaccharide ADZ27_18670 ENOG4107RJ7 Glycosyl transferase (Group 1 ADZ27_18675 ENOG4105DKP glycosyl transferase, family 9 ADZ27_18680 ENOG4105D8A 3-Deoxy-D-manno-octulosonic-acid transferase ADZ27_18695 ENOG4105W0E 50S ribosomal protein L33 ADZ27_18710 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase ADZ27_18715 ENOG4108Z1K This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) ADZ27_18735 ENOG4105DSJ YicC domain protein ADZ27_18740 ENOG4105F5P DNA-damage-inducible protein d ADZ27_18745 ENOG4105EN6 Membrane ADZ27_18755 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) ADZ27_18760 ENOG4105VFG Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) ADZ27_18765 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) ADZ27_18770 ENOG4105FE8 tRNA (Guanosine-2'-O-)-methyltransferase ADZ27_18775 ENOG4105CB5 ATP-dependent DNA helicase recG ADZ27_18780 ENOG4105D6U Sodium Glutamate Symporter ADZ27_18785 ENOG4105C2W permease ADZ27_18790 ENOG4105JV1 AsmA family ADZ27_18795 ENOG4105CJQ hydrolase, family 31 ADZ27_18800 ENOG4105CT4 transporter ADZ27_18815 ENOG4105S8Q sugar efflux transporter ADZ27_18820 ENOG4108UZ3 Transporter ADZ27_18825 ENOG4105D01 (LipO)protein ADZ27_18835 ENOG4105T8A Uncharacterized protein YicS ADZ27_18845 ENOG4108SAJ Protein of unknown function (DUF1198) ADZ27_18850 ENOG4105C7N Xanthine uracil vitamin C permease ADZ27_18860 ENOG4105CXY transporter ADZ27_18865 ENOG4105CXY transporter ADZ27_18870 ENOG4105BZU Histidine kinase ADZ27_18875 ENOG4108KX4 response regulator ADZ27_18880 ENOG4105M71 acetolactate synthase 1 regulatory subunit ADZ27_18885 ENOG4105C7K acetolactate synthase ADZ27_18910 ENOG4105E5M Multidrug resistance protein D ADZ27_18915 ENOG4105J13 transcriptional regulator ADZ27_18920 ENOG4105JP4 Inner membrane protein yidG ADZ27_18925 ENOG4105VG5 Membrane ADZ27_18930 ENOG4106DRA Inner membrane protein YidI ADZ27_18935 ENOG4105CBG Sulfatase ADZ27_18940 ENOG4107RUZ Sss sodium solute transporter superfamily ADZ27_18945 ENOG4108AHD Transcriptional regulator ADZ27_18965 ENOG4105FDP GntR family transcriptional regulator ADZ27_18985 ENOG4105R2A (LipO)protein ADZ27_18990 ENOG4105D99 atp gtp-binding protein ADZ27_18995 ENOG4107WAP fad NAD(P)-binding domain ADZ27_19000 ENOG4105DJB Major Facilitator Superfamily ADZ27_19010 ENOG4108RTU Aldolase ADZ27_19015 ENOG4105EI3 2-dehydro-3-deoxygalactonokinase EC 2.7.1.58 ADZ27_19020 ENOG4105EMF GntR family transcriptional regulator ADZ27_19025 ENOG410657R replicase EC 2.7 ADZ27_19030 ENOG410667J hydrolase ADZ27_19035 ENOG4105VP5 Bacterial protein of unknown function (DUF937) ADZ27_19045 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) ADZ27_19055 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) ADZ27_19105 ENOG4105F2I Transposase ADZ27_19125 ENOG4105E8Q phosphopantetheinyl transferase ADZ27_19130 ENOG4108YYH Nadph-dependent fmn reductase ADZ27_19135 ENOG4105C7N Xanthine uracil vitamin C permease ADZ27_19140 ENOG4107UB3 HAD-superfamily hydrolase subfamily IA variant 3 ADZ27_19145 ENOG4106HGK Inner membrane protein yieI ADZ27_19150 ENOG4106611 bacteriocin immunity ADZ27_19155 ENOG4107VKM 6-phosphogluconolactonase ADZ27_19160 ENOG4105DYC esterase ADZ27_19165 ENOG4108P68 Outer membrane porin ADZ27_19170 ENOG4105CS2 ec 3.2.1.21 ADZ27_19175 ENOG4105C5Y PTS System ADZ27_19180 ENOG4105CID antiterminator ADZ27_19185 ENOG4108UTW Plays a role in the regulation of phosphate uptake ADZ27_19190 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) ADZ27_19195 ENOG4105E2Z phosphate ABC transporter (Permease ADZ27_19200 ENOG4105C8U phosphate abc transporter ADZ27_19205 ENOG4107QMV Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity) ADZ27_19210 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) ADZ27_19250 ENOG4105KY6 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) ADZ27_19260 ENOG4105GXX Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit I associates with the membrane and may be involved with cation translocation ADZ27_19275 ENOG4105QTB Flavodoxin ADZ27_19280 ENOG4108VVK transcriptional Regulator, AsnC ADZ27_19290 ENOG4105EV2 VWA domain protein interacting with AAA ATPase ADZ27_19305 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) ADZ27_19310 ENOG4105C2J ABC transporter ADZ27_19315 ENOG4105CNN ABC, transporter ADZ27_19320 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator ADZ27_19325 ENOG4108RVA ribokinase ADZ27_19335 ENOG4105C0R drug resistance transporter emrb qaca subfamily ADZ27_19340 ENOG4107EJG GntR family transcriptional regulator ADZ27_19380 ENOG4108WFC UPF0438 protein yifE ADZ27_19385 ENOG4105C0P Mg chelatase subunit ChlI ADZ27_19400 ENOG4105P3Y Acetolactate synthase 2 regulatory subunit ADZ27_19405 ENOG4105CM2 brancheD-chain amino acid aminotransferase ADZ27_19415 ENOG4105C7B Threonine dehydratase ADZ27_19420 ENOG4105EMY transcriptional regulator ADZ27_19430 ENOG4105KQ5 peptidylprolyl cis-trans isomerase ADZ27_19440 ENOG4105C4R Atp-dependent dna helicase ADZ27_19445 ENOG4105C9X ppx gppa phosphatase ADZ27_19455 ENOG4105K63 Thioredoxin ADZ27_19475 ENOG4105ESV Glycosyl transferase, family 4 ADZ27_19480 ENOG4105SFE lipopolysaccharide biosynthesis protein ADZ27_19485 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase ADZ27_19490 ENOG4108IJ1 Dehydrogenase ADZ27_19495 ENOG4105C1B dTDP-glucose 4-6-dehydratase ADZ27_19500 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) ADZ27_19505 ENOG4108WJ1 acetyltransferase ADZ27_19510 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase ADZ27_19515 ENOG4105EGZ biosynthesis protein ADZ27_19535 ENOG4105C85 amino acid ADZ27_19560 ENOG4105C4X radical SAM domain protein ADZ27_19565 ENOG4105ENH Sulfatase ADZ27_19570 ENOG410601J HemY protein ADZ27_19575 ENOG4105ECF c-methyltransferase ADZ27_19580 ENOG41076E6 Uroporphyrinogen-III Synthase ADZ27_19590 ENOG4107T0K Adenylate cyclase ADZ27_19600 ENOG4105S7Z (LipO)protein ADZ27_19610 ENOG4105CT0 Protein of unknown function, DUF484 ADZ27_19620 ENOG4105DFC had-superfamily hydrolase, subfamily ia, variant ADZ27_19625 ENOG4105C4R Atp-dependent dna helicase ADZ27_19630 ENOG4108T58 Mg2 transport protein CorA ADZ27_19640 ENOG4107QUT magnesium and cobalt transport protein CorA ADZ27_19645 ENOG4105NRM Membrane ADZ27_19650 ENOG4106WR8 Inner membrane protein YigG ADZ27_19655 ENOG4105FR1 rard protein ADZ27_19660 ENOG4108VUY thioesterase Superfamily protein ADZ27_19665 ENOG4105HDD phospholipase ADZ27_19670 ENOG4105C9U ATP-dependent DNA helicase RecQ ADZ27_19685 ENOG4108EUD Lysophospholipase ADZ27_19690 ENOG4105DQF Hydrolase ADZ27_19695 ENOG4105EMK carboxylate amino acid amine transporter ADZ27_19700 ENOG4105DZ2 Transcriptional regulator ADZ27_19705 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) ADZ27_19710 ENOG4105CDZ Carboxymethylenebutenolidase (EC 3.1.1.45) ADZ27_19715 ENOG4108I5U Uridine phosphorylase ADZ27_19720 ENOG4105CGY Dna recombination protein ADZ27_19730 ENOG4105JC1 sterol-binding domain protein ADZ27_19740 ENOG4105WKS Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) ADZ27_19745 ENOG4105X8U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity) ADZ27_19750 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) ADZ27_19755 ENOG4105F8V Hydrolase, tatD family ADZ27_19760 ENOG4105MDZ Transcriptional activator rfaH ADZ27_19765 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) ADZ27_19770 ENOG4107QK7 reductase ADZ27_19775 ENOG4105CHU acetyl-coa acetyltransferase ADZ27_19790 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein ADZ27_19795 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) ADZ27_19800 ENOG4108RR8 protoporphyrinogen oxidase ADZ27_19830 ENOG4105FNP Molybdopterin-guanine dinucleotide biosynthesis protein b ADZ27_19835 ENOG4105C6R Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) ADZ27_19840 ENOG4105PC1 Conserved Protein ADZ27_19845 ENOG4105E27 serine threonine protein kinase ADZ27_19850 ENOG4108Z33 Thiol disulfide Interchange Protein ADZ27_19860 ENOG4106HNH Acyl-transferase ADZ27_19870 ENOG4105C2M dna polymerase I ADZ27_19885 ENOG4105D4P Coproporphyrinogen iii oxidase ADZ27_19890 ENOG4106FIY ADZ27_19895 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family ADZ27_19900 ENOG4105CUX Signal transduction histidine kinase ADZ27_19905 ENOG4105C5F glutamine synthetase ADZ27_19920 ENOG4108K85 Transcriptional regulator ADZ27_19925 ENOG4108KHF Resistance protein ADZ27_19930 ENOG4105R9B Major Facilitator ADZ27_19935 ENOG4108KUC Outer membrane channel protein that allows an efficient diffusion of low-molecular-weight solutes such as small sugars and tetraglycine. However, the specific substrate recognized by the OmpL channel is ADZ27_19940 ENOG4105CT4 transporter ADZ27_19945 ENOG4105CT4 transporter ADZ27_19950 ENOG4105CJQ hydrolase, family 31 ADZ27_19955 ENOG4107WI4 Aldose-1-epimerase ADZ27_19960 ENOG4107QKS N-acylglucosamine 2-epimerase ADZ27_19965 ENOG4105D2M Aldolase ADZ27_19970 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase ADZ27_19975 ENOG4108MGF sugar kinase ADZ27_19980 ENOG4105E98 transcriptional regulator DeoR family ADZ27_19985 ENOG4105EJU HAD-superfamily hydrolase subfamily IA variant 3 ADZ27_20000 ENOG4105SUU thioesterase domain ADZ27_20005 ENOG4106UEE Transcriptional regulator ADZ27_20010 ENOG41068KX affects formate dehydrogenase-N ADZ27_20025 ENOG4108MG3 formate dehydrogenase ADZ27_20030 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein ADZ27_20035 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) ADZ27_20040 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) ADZ27_20050 ENOG4108V87 frv operon regulatory protein ADZ27_20055 ENOG4106C3V frv operon regulatory protein ADZ27_20060 ENOG4105CN9 Peptidase m42 family protein ADZ27_20065 ENOG4105DM4 PTS System ADZ27_20070 ENOG41064BA PTS system, fructose-specific, IIA component ADZ27_20115 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) ADZ27_20130 ENOG4108RPX mosc domain containing protein ADZ27_20135 ENOG4105E0F Histidine kinase ADZ27_20140 ENOG4105E3W Two component transcriptional regulator (Winged helix family ADZ27_20145 ENOG4105FMW periplasmic ADZ27_20160 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein ADZ27_20175 ENOG4105EBK exported protein ADZ27_20180 ENOG4108VTS Membrane ADZ27_20185 ENOG41065TG regulatoR ADZ27_20195 ENOG4105DP0 ferredoxin-NADP reductase ADZ27_20200 ENOG4105CBT Fructose-1,6-bisphosphatase ADZ27_20210 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) ADZ27_20225 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase ADZ27_20230 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) ADZ27_20240 ENOG41063M6 Cell Division Protein ADZ27_20245 ENOG4105ETE Transcriptional regulator (LacI family ADZ27_20250 ENOG4105C25 Primosomal protein n' ADZ27_20260 ENOG4107S01 Repressor protein MetJ ADZ27_20270 ENOG4105C28 cystathionine ADZ27_20275 ENOG4105CFH Aspartokinase ADZ27_20285 ENOG4105SYT Methylenetetrahydrofolate reductase ADZ27_20290 ENOG4105C1X Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity (By similarity) ADZ27_20295 ENOG4108Q5Y Membrane ADZ27_20300 ENOG4108XC3 NADH ubiquinone oxidoreductase ADZ27_20310 ENOG4105DCT glycerol dehydrogenase ADZ27_20315 ENOG4107T9Z Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) ADZ27_20320 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) ADZ27_20325 ENOG4105DM4 PTS System ADZ27_20330 ENOG4108YRF PTS System ADZ27_20335 ENOG4105C6N Formate acetyltransferase ADZ27_20340 ENOG4108AHH pyruvate formate lyase II activase ADZ27_20345 ENOG4108XCZ PTS System ADZ27_20350 ENOG4106R3P AraC family transcriptional regulator ADZ27_20355 ENOG4105DIJ Phosphoethanolamine transferase ADZ27_20375 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase ADZ27_20390 ENOG4105C5Q Transcriptional regulator ADZ27_20405 ENOG4108Y73 Membrane ADZ27_20415 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) ADZ27_20445 ENOG4105D4A Cell wall formation (By similarity) ADZ27_20450 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase ADZ27_20490 ENOG4105PM1 preprotein translocase subunit SecE ADZ27_20495 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) ADZ27_20530 ENOG410645W Thiamin biosynthesis protein ThiH ADZ27_20535 ENOG4105D41 biosynthesis protein thiH ADZ27_20545 ENOG4105WHD thiamine biosynthesis protein ThiS ADZ27_20550 ENOG4105D06 uba thif-type nad fad binding protein ADZ27_20585 ENOG4105R2J Conserved Protein ADZ27_20590 ENOG4105K70 DNA-binding protein ADZ27_20595 ENOG4108T8B Protein of unknown function (DUF1481) ADZ27_20600 ENOG4105JBU Binds zinc. Could be an important component of the zinc- balancing mechanism ADZ27_20605 ENOG4105BZU Histidine kinase ADZ27_20610 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family ADZ27_20615 ENOG4105C12 Phosphoribosylglycinamide synthetase ADZ27_20645 ENOG41062WK cellular response to acidity ADZ27_20650 ENOG4105K5X acetyltransferase ADZ27_20660 ENOG4107QP3 malate synthase g ADZ27_20665 ENOG4108I9X Isocitrate lyase ADZ27_20680 ENOG41069M3 Transcriptional regulator ADZ27_20685 ENOG4105C3R Methionine synthase ADZ27_20690 ENOG4105EAM Na Pi-cotransporter ADZ27_20700 ENOG4105FE9 pseudouridine synthase ADZ27_20705 ENOG4108ZR5 Conserved Protein ADZ27_20710 ENOG4105CFH Aspartokinase ADZ27_20725 ENOG4108MDC (LipO)protein ADZ27_20730 ENOG4108Q9C Periplasmic Protein ADZ27_20735 ENOG4105E3R (LipO)protein ADZ27_20755 ENOG4107QNK )-transporter ADZ27_20760 ENOG4105EG2 ABC transporter, permease ADZ27_20765 ENOG4105D56 permease protein ADZ27_20770 ENOG4107FKK extracellular solute-binding protein family 1 ADZ27_20780 ENOG4108IJ9 (ABC) transporter ADZ27_20790 ENOG4107W52 maltose operon periplasmic protein ADZ27_20820 ENOG41080IJ Diacylglycerol kinase ADZ27_20830 ENOG4107R73 Mate efflux family protein ADZ27_20835 ENOG4105VDW Csbd family ADZ27_20840 ENOG4105MYN Zinc uptake regulation protein ADZ27_20855 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) ADZ27_20860 ENOG4105P4Z Phage shock protein G ADZ27_20865 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein ADZ27_20870 ENOG4105CDU Replicative dna helicase ADZ27_20875 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) ADZ27_20880 ENOG4105CGF Aromatic amino acid aminotransferase ADZ27_20890 ENOG4105F0S class B acid phosphatase ADZ27_20895 ENOG4108YXI Secondary thiamine-phosphate synthase enzyme ADZ27_20900 ENOG4105MSB protein, conserved in bacteria ADZ27_20905 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) ADZ27_20910 ENOG4108UUM single-stranded DNA-binding protein ADZ27_20915 ENOG4105PMV Membrane ADZ27_20920 ENOG4108M8H domain protein ADZ27_20925 ENOG4108W3Q Transcriptional regulator ADZ27_20930 ENOG4108Z4X TRANSCRIPTIONal ADZ27_20935 ENOG4105C7N Xanthine uracil vitamin C permease ADZ27_20940 ENOG4105EEQ Na H antiporter ADZ27_20955 ENOG41062QD Membrane ADZ27_20960 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) ADZ27_20970 ENOG4105JJ8 Cytochrome c nitrite reductase, pentaheme subunit ADZ27_20975 ENOG4105D3S 4Fe-4S Ferredoxin, iron-sulfur binding domain protein ADZ27_20980 ENOG4105DVI reductase, NrfD ADZ27_20985 ENOG4108QKW cytochrome c-type biogenesis protein ADZ27_20995 ENOG4108W0S formate-dependent nitrite reductase complex ADZ27_21000 ENOG4105CK2 sodium dicarboxylate symporter ADZ27_21005 ENOG41082ND Uncharacterized protein yjcO ADZ27_21010 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) ADZ27_21015 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) ADZ27_21020 ENOG4105ETP RND efflux system, outer membrane lipoprotein ADZ27_21025 ENOG4108MI0 Resistance protein ADZ27_21030 ENOG4105J12 Multidrug resistance protein mdtN ADZ27_21035 ENOG4106833 ADZ27_21040 ENOG4105EUZ Beta-lactamase domain protein ADZ27_21045 ENOG4107TFG D-allose kinase ADZ27_21050 ENOG4105UP7 3-epimerase ADZ27_21055 ENOG4105CNN ABC, transporter ADZ27_21060 ENOG4105C2J ABC transporter ADZ27_21065 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator ADZ27_21070 ENOG4105NYY transcriptional regulator, RpiR ADZ27_21075 ENOG4108YZG isomerase ADZ27_21080 ENOG4106ZVZ Escherichia coli IMT2125 genomic chromosome, IMT2125 ADZ27_21085 ENOG4107SA6 carbon-phosphorus lyase complex accessory protein ADZ27_21090 ENOG410849A acetyltransferase, (GNAT) family ADZ27_21095 ENOG4105MFQ Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP) (By similarity) ADZ27_21100 ENOG4105FD8 phosphonate metabolism protein PhnM ADZ27_21105 ENOG4105HRV phosphonate c-p lyase system protein phnl ADZ27_21110 ENOG4105ENV phosphonate C-P lyase system protein PhnK ADZ27_21115 ENOG4105FT8 Phosphonate metabolism ADZ27_21120 ENOG4105EKV Phosphonate metabolism protein ADZ27_21125 ENOG4105KZ6 phosphonate C-P lyase system protein PhnH ADZ27_21130 ENOG4105KQZ Phosphonate C-P lyase system protein PhnG ADZ27_21135 ENOG4107RJJ Transcriptional regulator ADZ27_21145 ENOG4105EHI Phosphonate ABC transporter, periplasmic ADZ27_21150 ENOG4105D5T phosphonate abc transporter ADZ27_21155 ENOG4108SQ4 Glyoxalase Bleomycin resistance protein (Dioxygenase ADZ27_21160 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA ADZ27_21165 ENOG4108F5E vimentin ADZ27_21170 ENOG4108YIV ADZ27_21175 ENOG4105CSH Transporter ADZ27_21185 ENOG4105ECM Sensor protein basS pmrB ADZ27_21190 ENOG4105XJC Two component transcriptional regulator (Winged helix family ADZ27_21195 ENOG4105DIJ Phosphoethanolamine transferase ADZ27_21200 ENOG4105D5Q Arginine ornithine antiporter ADZ27_21205 ENOG4106ZGR Transcriptional regulator ADZ27_21210 ENOG4105CXN decarboxylase ADZ27_21215 ENOG4108K2B transcriptional regulator ADZ27_21225 ENOG4105F8D glycoside hydrolase family 4 ADZ27_21230 ENOG4105CT4 transporter ADZ27_21235 ENOG4108R5S membrane ADZ27_21240 ENOG4107GFK fumarate ADZ27_21245 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter ADZ27_21255 ENOG4108MRH transcriptional regulatory protein ADZ27_21260 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism ADZ27_21265 ENOG4105VR1 Pfam:DUF1271 ADZ27_21270 ENOG410830R acetyltransferase ADZ27_21285 ENOG4105CRK lysyL-tRNA synthetase ADZ27_21290 ENOG4105DUX Transporter ADZ27_21295 ENOG4105CXN decarboxylase ADZ27_21300 ENOG4105D5Q Arginine ornithine antiporter ADZ27_21310 ENOG4108M3R transcriptional activator CadC ADZ27_21320 ENOG4108SIC Transcriptional regulator ADZ27_21325 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) ADZ27_21335 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter ADZ27_21340 ENOG4108IJ0 Aspartate ammonia-lyase ADZ27_21345 ENOG4108YH1 overproduction of this protein in Escherichia coli inhibits the F plasmid-mediated exclusion of bacteriophage T7 ADZ27_21350 ENOG4105DVH amino acid ADZ27_21365 ENOG4108ZVF (LipO)protein ADZ27_21370 ENOG4105MTB Uncharacterized protein YjeJ ADZ27_21375 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein ADZ27_21385 ENOG4106HKS Entericidin EcnA/B family ADZ27_21390 ENOG4106BSU Entericidin B ADZ27_21395 ENOG4105KPY Small multidrug resistance protein ADZ27_21400 ENOG4105QNF Outer membrane lipoprotein ADZ27_21405 ENOG41066YJ Beta-lactamase ADZ27_21420 ENOG4105E33 succinate dehydrogenase ADZ27_21425 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) ADZ27_21435 ENOG4107SC7 Inner membrane transporter yjeM ADZ27_21440 ENOG4106V5W ADZ27_21445 ENOG4106CG8 Inner membrane protein YjeO ADZ27_21450 ENOG4105EGS Mechanosensitive ion channel ADZ27_21485 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) ADZ27_21490 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) ADZ27_21495 ENOG4105K8N protein family UPF0079, ATPase ADZ27_21500 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase ADZ27_21515 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) ADZ27_21520 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) ADZ27_21525 ENOG4107QJR hflk protein ADZ27_21530 ENOG4105EPW hflc protein ADZ27_21550 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) ADZ27_21555 ENOG4105C2N RNA methyltransferase TrmH family group 3 ADZ27_21560 ENOG4105FUX Conserved Protein ADZ27_21565 ENOG4108P9J Phage shock protein A ADZ27_21570 ENOG4107VNS Protein of unknown function (DUF2491) ADZ27_21575 ENOG4105Z6B inner membrane protein yjfl ADZ27_21580 ENOG4108KXT Conserved Protein ADZ27_21585 ENOG4106032 Glutathionylspermidine synthase ADZ27_21590 ENOG4105CSU acyl-Coa dehydrogenase ADZ27_21595 ENOG4105S17 UPF0379 protein yjfN ADZ27_21600 ENOG4105WSB biofilm stress and motility protein A ADZ27_21605 ENOG4108MXZ Esterase ADZ27_21620 ENOG4105CZC PTS system ascorbate-specific transporter subunit IIC ADZ27_21625 ENOG410907W The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in ascorbate transport ADZ27_21630 ENOG4106ETB IIa component ADZ27_21650 ENOG4105KIT UPF0379 protein yjfY ADZ27_21670 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) ADZ27_21695 ENOG4108RNI 3'(2')5'-bisphosphate nucleotidase ADZ27_21705 ENOG4108UUE Transcriptional regulator ADZ27_21710 ENOG41061GZ Protein of unknown function (DUF1107) ADZ27_21715 ENOG4105C37 (CBS) domain ADZ27_21730 ENOG4105CFU surface antigen ADZ27_21735 ENOG4105MA0 exported protein ADZ27_21740 ENOG4108ZHD aig2 family ADZ27_21745 ENOG41087RY SpoVT_AbrB ADZ27_21750 ENOG4105MZG transcriptional modulator of maze toxin, mazf ADZ27_21755 ENOG4105F0N pyrophosphate phospho-hydrolase ADZ27_21760 ENOG4107R5U Periplasmic binding protein LacI transcriptional regulator ADZ27_21765 ENOG4105C2J ABC transporter ADZ27_21770 ENOG4107R9N ABC transporter ADZ27_21775 ENOG41062B0 ABC transporter, permease ADZ27_21785 ENOG4105DFU Cell wall formation (By similarity) ADZ27_21795 ENOG4105CMS peptidase U62, modulator of DNA gyrase ADZ27_21805 ENOG4108RDD Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine (By similarity) ADZ27_21810 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase ADZ27_21815 ENOG4105CG3 alpha amylase, catalytic region ADZ27_21820 ENOG4105C5Y PTS System ADZ27_21825 ENOG4105D4X repressor ADZ27_21830 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic ADZ27_21835 ENOG4105KME endoribonuclease L-psp ADZ27_21850 ENOG41077AM PyrBI operon attenuator ADZ27_21860 ENOG4108UQ8 endoribonuclease L-psp ADZ27_21865 ENOG4105F6U Short-chain dehydrogenase reductase Sdr ADZ27_21870 ENOG4108XFH Transcriptional regulator ADZ27_21875 ENOG4105XEP YhcH YjgK YiaL family protein ADZ27_21885 ENOG4105DBV ornithine carbamoyltransferase ADZ27_21890 ENOG4105KQT Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome (By similarity) ADZ27_21895 ENOG4108MJ3 acetyltransferase ADZ27_21900 ENOG4108M3P Membrane ADZ27_21905 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) ADZ27_21910 ENOG4105MYG DNA polymerase iii, chi subunit ADZ27_21920 ENOG4108M8S permease YjgP YjgQ family protein ADZ27_21925 ENOG4108K5H permease YjgP YjgQ family protein ADZ27_21930 ENOG4105D7A ATP-binding protein ADZ27_21935 ENOG4105K2J Transcriptional regulator ADZ27_21940 ENOG4105C6Z Gluconate ADZ27_21945 ENOG4105CHR reductase ADZ27_21950 ENOG4105CPQ Dehydrogenase ADZ27_21955 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family ADZ27_21960 ENOG4105DQ4 alcohol dehydrogenase ADZ27_21975 ENOG4108ZQS transposase ADZ27_21980 ENOG4108MVM Transposase ADZ27_21990 ENOG4108I6E Sulfatase ADZ27_22010 ENOG4105VNT transposase (IS4 family) protein ADZ27_22015 ENOG4105JHE Major Facilitator Superfamily ADZ27_22020 ENOG4107RJ5 oxidoreductase ADZ27_22040 ENOG4105F9F transposase ADZ27_22060 ENOG4105E0A ABC, transporter ADZ27_22065 ENOG4108IHU transport system permease protein ADZ27_22070 ENOG4105DQ5 transport system permease protein ADZ27_22075 ENOG4108HUF Transporter ADZ27_22080 ENOG4105GAV receptor ADZ27_22085 ENOG4108S3W Anti-feci sigma factor, fecr ADZ27_22090 ENOG4108SF5 RNA Polymerase ADZ27_22110 ENOG4105DKT Transcriptional regulator ADZ27_22120 ENOG4105C6Z Gluconate ADZ27_22125 ENOG4105C01 Dihydroxy-acid dehydratase ADZ27_22130 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) ADZ27_22135 ENOG4106P37 HTH-type transcriptional regulator YjhI ADZ27_22140 ENOG4108PQ7 sgc region transcriptional regulator ADZ27_22145 ENOG4108RK0 3-epimerase ADZ27_22150 ENOG4108XBJ The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane (By similarity) ADZ27_22155 ENOG4106P19 photosystem i assembly btpa ADZ27_22160 ENOG4105DT3 PTS system, galactitol-specific IIc component ADZ27_22165 ENOG4105K18 The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane (By similarity) ADZ27_22170 ENOG4105CN9 Peptidase m42 family protein ADZ27_22175 ENOG4105DTA methyltransferase ADZ27_22180 ENOG41080VW acetyltransferase ADZ27_22210 ENOG4108MX5 Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses (By similarity) ADZ27_22215 ENOG41069FU Outer membrane channel protein allowing the entry of N- acetylneuraminic acid (Neu5Ac, the most abundant sialic acid on host cell surfaces) into the bacteria ADZ27_22230 ENOG4108W9T type 1 fimbriae regulatory protein ADZ27_22235 ENOG4105E71 FimE is one of the 2 regulatory proteins which control the phase variation of type 1 fimbriae in E.coli. These proteins mediate the periodic inversion of a 300bp DNA segment that harbors the promoter for the fimbrial structural gene, fimA. FimE switches fimA off ADZ27_22245 ENOG4108RQP Major type 1 subunit fimbrin ADZ27_22250 ENOG4108S54 Fimbrial protein ADZ27_22255 ENOG4108NAE Fimbrial chaperone protein ADZ27_22260 ENOG4105CW0 outer membrane usher protein ADZ27_22265 ENOG4108SQA Fimbrial ADZ27_22270 ENOG4108T65 Fimbrial ADZ27_22275 ENOG410643X FIMH SUBUNIT MANNOSE-sensitive type 1 fimbrial adhesin ADZ27_22280 ENOG4107EFN gluconate transport system permease 3 ADZ27_22295 ENOG4105DEI Mannitol dehydrogenase ADZ27_22305 ENOG4105C6F GntR Family Transcriptional Regulator ADZ27_22335 ENOG4107YNJ LysR family Transcriptional regulator ADZ27_22340 ENOG4105DYB Isoaspartyl dipeptidase ADZ27_22345 ENOG4108P2H Inner membrane protein YjiG ADZ27_22350 ENOG41074DU domain protein ADZ27_22360 ENOG4105CBP Major Facilitator ADZ27_22365 ENOG4108ZK4 sdia-regulated domain-containing protein ADZ27_22375 ENOG4105CIZ coA-substrate-specific enzyme activase ADZ27_22380 ENOG4105DCU 2-hydroxyglutaryl-CoA dehydratase ADZ27_22385 ENOG4106BRA Membrane ADZ27_22390 ENOG41083G8 Multidrug resistance protein MdtM ADZ27_22400 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family ADZ27_22405 ENOG4106DIZ Domain of unknown function (DUF1127) ADZ27_22410 ENOG4108YUH ADZ27_22420 ENOG4107SQC 5-methylcytosine-specific restriction enzyme subunit McrC ADZ27_22425 ENOG4105FBQ ATPase associated with various cellular activities aaa_5 ADZ27_22435 ENOG4107XZC Restriction modification system DNA (Specificity ADZ27_22440 ENOG4105CVR type I restriction-modification system ADZ27_22450 ENOG4106H3A restriction ADZ27_22455 ENOG4105CKI cobalamin synthesis protein ADZ27_22460 ENOG4105VCD cytoplasmic protein ADZ27_22465 ENOG4105D22 carbon starvation protein ADZ27_22475 ENOG4105C8Q Methyl-accepting chemotaxis ADZ27_22480 ENOG4108I5G Major Facilitator superfamily ADZ27_22485 ENOG410617M Transcriptional regulator ADZ27_22490 ENOG4105CPQ Dehydrogenase ADZ27_22500 ENOG4105RI1 glycoprotein receptor ADZ27_22505 ENOG4106CVF DNA replication protein ADZ27_22520 ENOG4105DWK Membrane ADZ27_22525 ENOG4108N8T regulatoR ADZ27_22530 ENOG4108T94 DNA-binding transcriptional activator BglJ ADZ27_22535 ENOG4108819 ferric iron reductase ADZ27_22540 ENOG4105YBH Protein of unknown function (DUF1435) ADZ27_22565 ENOG4108WPU DNA polymerase III subunit psi ADZ27_22570 ENOG4105KEG ribosomal-protein-alanine acetyltransferase ADZ27_22575 ENOG4105PAD Hydrolase ADZ27_22585 ENOG4105K3G Periplasmic Protein ADZ27_22595 ENOG4108NRW Phospholipase, patatin family ADZ27_22600 ENOG4105EYA deoxyribonuclease ADZ27_22605 ENOG41076CZ activating enzyme ADZ27_22610 ENOG4105G0K glycine radical enzyme YjjI family ADZ27_22640 ENOG4105EUP HipA domain protein ADZ27_22650 ENOG4107RMF Catalyzes both the ATP-dependent activation of exogenously supplied lipoate to lipoyl-AMP and the transfer of the activated lipoyl onto the lipoyl domains of lipoate-dependent enzymes (By similarity) ADZ27_22655 ENOG4105EAC phosphoserine phosphatase ADZ27_22660 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) ADZ27_22665 ENOG4107VZS Nicotinamide-nucleotide adenylyltransferase ADZ27_22675 ENOG4105C5H ABC transporter ADZ27_22680 ENOG4107SC1 transglycosylase ADZ27_22700 ENOG4105UEI Transcriptional Regulator AraC Family ADZ27_22705 ENOG4108RH0 Crea protein ADZ27_22710 ENOG4105E3W Two component transcriptional regulator (Winged helix family ADZ27_22715 ENOG4105EB3 Histidine kinase ADZ27_22720 ENOG4105CT7 inner membrane cred family protein ADZ27_22725 ENOG41065U4 response regulator ADZ27_22730 ENOG410759A ADZ27_22735 ENOG4106FVC RNA methyltransferase