locus-tag class description FX998_00005 ENOG4105RK8 Plays a role in the extracellular assembly of CsgA into thin aggregative fimbriae (Tafi) fibers. Assembly may also require CsgE. Tafi are thought to be assembled via an extracellular nucleation-precipitation (ENP) pathway, and possibly also via an intracellular non-CsgC-dependent pathway (By similarity) FX998_00015 ENOG4108UVJ appr-1-p processing domain protein FX998_00020 ENOG4107RZC phospholipase d FX998_00035 ENOG4105C3A Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs) (By similarity) FX998_00040 ENOG4105NAC (LipO)protein FX998_00045 ENOG4108W47 Acidic protein msyB FX998_00055 ENOG4105D1S lipid A biosynthesis FX998_00065 ENOG4108YYC ycei family FX998_00070 ENOG4105DS1 cytochrome b561 FX998_00075 ENOG4106974 biofilm formation FX998_00085 ENOG4105PVA Biofilm formation regulatory protein BssS FX998_00090 ENOG4105MEA DNA damage-inducible protein i FX998_00100 ENOG4105F3T (LipO)protein FX998_00105 ENOG4105E9S glutaredoxin 2 FX998_00115 ENOG4105D9U N-acetyltransferase FX998_00125 ENOG4105EP9 oxidoreductase FX998_00130 ENOG4105CJR Integral membrane protein (MviN FX998_00135 ENOG4105QVD Flagella synthesis protein FlgN FX998_00140 ENOG4105M9M anti-sigma28 factor FlgM FX998_00145 ENOG4105CKS Flagella basal body P-ring formation protein flgA FX998_00150 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) FX998_00155 ENOG4108ZC9 flagellar basal-body rod protein flgc FX998_00160 ENOG4105W00 Flagellar hook capping protein FX998_00165 ENOG4105BZE flagellar hook protein, FlgE FX998_00170 ENOG4108KPB Flagellar basal-body rod protein FlgF FX998_00175 ENOG4105CGA flagellar basal-body rod protein FlgG FX998_00190 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj FX998_00195 ENOG4105E1Q flagellar hook-associated protein FX998_00200 ENOG4105DTJ flagellar hook-associated protein FX998_00205 ENOG4107QQB Ribonuclease E FX998_00215 ENOG4105EI2 Pseudouridine synthase FX998_00220 ENOG4108UHJ MAF-like protein FX998_00225 ENOG4105FCQ metal-binding, possibly nucleic acid-binding protein FX998_00245 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase FX998_00250 ENOG4105CHR reductase FX998_00255 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) FX998_00260 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) FX998_00265 ENOG4105YAZ 4-amino-4-deoxychorismate lyase FX998_00270 ENOG4105HHA aminodeoxychorismate lyase FX998_00280 ENOG4107QRG dna polymerase iii FX998_00285 ENOG4105F8V Hydrolase, tatD family FX998_00290 ENOG4105CI1 PTS System FX998_00295 ENOG4105CNM Receptor FX998_00300 ENOG4105K59 histidine triad (HIT) protein FX998_00305 ENOG41090DQ Lipoprotein FX998_00310 ENOG4108WEF Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b) (By similarity) FX998_00330 ENOG4105CEP NADH dehydrogenase FX998_00335 ENOG4107MBR 17 kDa surface antigen FX998_00340 ENOG4108IND Tetr family transcriptional regulator FX998_00345 ENOG4105RC8 Reduces the permeability of the outer membrane to copper. Seems to be involved in the regulation of biofilm formation. May decrease biofilm formation by repressing cell-cell interaction and cell surface interaction FX998_00350 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein FX998_00355 ENOG4108JA2 transcriptioN-repair coupling factor FX998_00360 ENOG4105IQC Inner membrane protein YcfT FX998_00365 ENOG4105D60 lipoprotein releasing system transmembrane protein FX998_00370 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) FX998_00375 ENOG4105D60 lipoprotein releasing system transmembrane protein FX998_00385 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) FX998_00400 ENOG4107RUE extracellular solute-binding protein family 1 FX998_00405 ENOG4105D38 putrescine abc transporter FX998_00410 ENOG4108I1J Integrase FX998_00420 ENOG41076J9 exonuclease VIII FX998_00425 ENOG4106G8A Qin prophage FX998_00490 ENOG4105D70 Integrase catalytic subunit FX998_00510 ENOG4105WI6 cell killing protein encoded within cryptic prophage FX998_00520 ENOG4108MXB Protein of unknown function (DUF968) FX998_00525 ENOG4105KSK (crossover) junction endodeoxyribonuclease FX998_00530 ENOG4105HGD Antitermination protein FX998_00560 ENOG4105QFS Lysis protein S homolog from lambdoid prophage FX998_00580 ENOG4105QYK bacteriophage lambda Bor protein homolog FX998_00705 ENOG4105EKQ RNA-directed DNA polymerase FX998_00735 ENOG4108WF3 methyltransferase FX998_00745 ENOG4105F38 ABC transporter, permease FX998_00750 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FX998_00760 ENOG4105EZE Cupin 4 family protein FX998_00765 ENOG4105IFJ Histidine kinase FX998_00770 ENOG4105XJC Two component transcriptional regulator (Winged helix family FX998_00775 ENOG4107QTF adenylosuccinate lyase FX998_00795 ENOG4108R99 pseudouridine synthase FX998_00800 ENOG4108HMX isocitrate dehydrogenase (NADP) FX998_00815 ENOG41064WM Uncharacterized protein YcgX FX998_00820 ENOG4108XDN Transcriptional regulator FX998_00825 ENOG4105BZU Histidine kinase FX998_00830 ENOG4105WKE Probably a connector protein for RcsB C regulation of biofilm formation, providing additional signal input into the two- component signaling pathway. Partially antagonizes the activities of YmgA and AriR, proteins that, via the Rcs phosphorelay, promote the synthesis of colanic acid, an exopolysaccharide and matrix component FX998_00835 ENOG41077SS Probably a connector protein for RcsB C regulation of biofilm formation, providing additional signal input into the two- component signaling pathway. May serve to stimulate biofilm maturation, probably via the Rcs phosphorelay. Mild overexpression at 16 degrees Celsius increases the production of colanic acid, an exopolysaccharide and matrix component, and reduces adhesive curli fimbriae expression. Both of these effects require RcsB FX998_00845 ENOG410738I uncharacterized protein ymgC FX998_00850 ENOG4105BZU Histidine kinase FX998_00905 ENOG4107QMS site-determining protein FX998_00915 ENOG4105S66 prophage protein FX998_00920 ENOG41066UD Inhibits activity of g-type lysozyme, which confers increased lysozyme tolerance to the bacterium FX998_00930 ENOG4105FBJ fumarylacetoacetate (faa) hydrolase FX998_00940 ENOG4106PXS Toxin, which has some hemolytic activity towards mammalian cells. Acts by forming a pore-like structure upon contact with mammalian cells FX998_00945 ENOG4105KT5 UmuD protein FX998_00950 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) FX998_00955 ENOG410635M Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein (By similarity) FX998_00970 ENOG4105ED1 spovr family FX998_00980 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) FX998_00990 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A FX998_01000 ENOG4108T7K Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Increasing levels of c-di-GMP lead to decreased motility (By similarity) FX998_01005 ENOG4105Y3U Transglycosylase-associated protein FX998_01020 ENOG4105VDH Dihydroxyacetone kinase FX998_01025 ENOG4108UTZ Dihydroxyacetone kinase FX998_01030 ENOG4105CMT Dihydroxyacetone kinase FX998_01035 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family FX998_01040 ENOG4105I1J Autotransporter FX998_01045 ENOG4105C3G gtp-binding protein FX998_01055 ENOG4105MGX transcription activated by CRP (cyclic AMP receptor protein), a global transcription factor involved in regulation of metabolism in enteric bacteria FX998_01060 ENOG4105CHH sulfate transporter FX998_01065 ENOG4105C5T Phosphoribosyl pyrophosphate synthase FX998_01070 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) FX998_01080 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) FX998_01090 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) FX998_01095 ENOG4108YY7 Invasion gene expression up-regulator SirB FX998_01100 ENOG41063JG Transcriptional regulator FX998_01140 ENOG4105EWV Sodium calcium exchanger membrane region FX998_01145 ENOG4105WS7 Cation transport regulator FX998_01150 ENOG4108NH8 Cation transport protein FX998_01155 ENOG41090EX DsrE family FX998_01160 ENOG4105ID0 Putative invasin FX998_01165 ENOG4105WH1 Two component transcriptional regulator luxr family FX998_01170 ENOG4105BZU Histidine kinase FX998_01175 ENOG4105DQQ Major facilitator superfamily MFS_1 FX998_01180 ENOG4105CRU nitrate reductase, alpha subunit FX998_01185 ENOG4108IUE nitrate reductase beta subunit FX998_01190 ENOG4105R3A Nitrate reductase FX998_01195 ENOG41076YT nitrate reductase, gamma subunit FX998_01230 ENOG4105CIY formyltetrahydrofolate deformylase FX998_01240 ENOG4105D78 K07001 NTE family protein FX998_01245 ENOG4105I93 response regulator FX998_01250 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase FX998_01255 ENOG4108SAU DNA-binding protein H-ns FX998_01260 ENOG4107104 thymidine kinase FX998_01270 ENOG4108EKI Dehydrogenase FX998_01275 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein FX998_01280 ENOG4108J59 Extracellular solute-binding protein, family 5 FX998_01290 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FX998_01295 ENOG4105C3U ABC transporter FX998_01300 ENOG4108JQ7 (ABC) transporter FX998_01320 ENOG4107SVH Potassium channel protein FX998_01325 ENOG4105K9H YciI-like protein FX998_01330 ENOG410822N TonB family FX998_01335 ENOG4105NAU thioesterase Superfamily protein FX998_01355 ENOG4105EIF outer membrane protein W FX998_01360 ENOG4108N8X transition metal ion binding FX998_01365 ENOG4108Z9Z response to DNA damage stimulus FX998_01385 ENOG4105DK0 Indole-3-glycerol phosphate synthase FX998_01390 ENOG4108EFP Anthranilate synthase component II FX998_01395 ENOG4105CRQ synthase (Component I) FX998_01405 ENOG4105DB7 PHP domain protein FX998_01410 ENOG4107RTD sua5 ycio yrdc ywlc family protein FX998_01415 ENOG4105EG3 transmembrane signal peptide protein FX998_01420 ENOG4105FE9 pseudouridine synthase FX998_01425 ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase FX998_01430 ENOG4105UBK short-chain dehydrogenase reductase FX998_01435 ENOG4105ERU peptidase FX998_01440 ENOG4105RKX Protein of unknown function (DUF2498) FX998_01445 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) FX998_01450 ENOG4107R11 Transcriptional regulator FX998_01475 ENOG4107QM5 aconitate hydratase FX998_01485 ENOG4105EYK Phosphatidylglycerophosphatase B FX998_01490 ENOG4105Q4A inner membrane protein yciS FX998_01495 ENOG4105CFV Tetratricopeptide repeat protein FX998_01505 ENOG4108ZJT translation initiation factor, Sui1 FX998_01510 ENOG41061RM osmotically inducible lipoprotein FX998_01515 ENOG4105N2W Transcriptional regulator FX998_01525 ENOG4105BZU Histidine kinase FX998_01540 ENOG4105Q4T oxidoreductase FX998_01545 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH FX998_01550 ENOG4105WDY DNA (cytosine-5-)-methyltransferase FX998_01555 ENOG4108JQ2 peptide transport system atp-binding protein FX998_01560 ENOG4108JQ3 Peptide ABC transporter ATP-binding protein FX998_01565 ENOG4108EU3 peptide transport system, permease FX998_01570 ENOG4108I5W peptide transport system, permease protein FX998_01575 ENOG4108HIY periplasmic FX998_01580 ENOG4105N0E Protein of unknown function (DUF2543) FX998_01585 ENOG4105CUB amino acid FX998_01595 ENOG4105CFQ glutamine synthetase FX998_01600 ENOG4108Z86 Glutamine amidotransferase FX998_01605 ENOG4107VRI Transcriptional regulator FX998_01610 ENOG4105C26 Dehydrogenase FX998_01615 ENOG4105CJP fad dependent oxidoreductase FX998_01620 ENOG4108JPW Aminotransferase FX998_01625 ENOG4105E51 psp operon transcriptional activator FX998_01630 ENOG41087YS Phage shock protein A FX998_01635 ENOG4105YYT phage shock protein B FX998_01640 ENOG4105FM1 phage shock protein C FX998_01645 ENOG4105NNG Peripheral inner membrane phage-shock protein FX998_01650 ENOG4105K8Z Phage shock protein FX998_01655 ENOG4107QW3 Sucrose phosphorylase FX998_01665 ENOG4105HS6 binding-protein-dependent transport systems inner membrane Component FX998_01670 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component FX998_01675 ENOG4107RRD Dehydrogenase FX998_01680 ENOG4107TYA transient receptor potential locus FX998_01685 ENOG4105CK5 oxidoreductase FX998_01690 ENOG4105C71 hydrolase family 65, central catalytic FX998_01695 ENOG4107URF beta-phospho-glucomutase FX998_01700 ENOG4108IJ9 (ABC) transporter FX998_01705 ENOG4107EFV Outer membrane protein G FX998_01710 ENOG4105FKQ transcriptional regulator FX998_01715 ENOG4105CM6 amino acid regulated cytosolic protein FX998_01725 ENOG4108JU8 Transcriptional regulator FX998_01730 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) FX998_01735 ENOG4107S8C mandelate racemase muconate lactonizing FX998_01740 ENOG4105KXI murein peptide amidase A FX998_01755 ENOG4105ENX hydrolase FX998_01760 ENOG4105EQ2 LysR family Transcriptional regulator FX998_01765 ENOG4107QSI ABC, transporter FX998_01770 ENOG4105D64 Mechanosensitive ion channel FX998_01775 ENOG4105S5I Membrane FX998_01780 ENOG4105Q9Y Universal stress protein FX998_01785 ENOG4105DS0 Transcriptional regulator, Crp Fnr family FX998_01790 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) FX998_01795 ENOG4105CFC Transporter FX998_01800 ENOG4107RT5 aminobenzoyl-glutamate utilization protein B FX998_01805 ENOG4105CH2 amidohydrolase FX998_01810 ENOG4106KR7 LysR family Transcriptional regulator FX998_01815 ENOG4108DG9 Smr protein MutS2 FX998_01820 ENOG4105BZU Histidine kinase FX998_01830 ENOG4105C1J atp-dependent rna helicase FX998_01840 ENOG4108RW8 Universal stress protein F FX998_01845 ENOG4105FCK Membrane FX998_01850 ENOG4105D95 Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity) FX998_01860 ENOG41090X5 Heat shock protein hslJ FX998_01865 ENOG4105C5I Dehydrogenase FX998_01870 ENOG4107H52 Dicarboxylate transport FX998_01875 ENOG410689M (LipO)protein FX998_01880 ENOG4105WXT Conserved Protein FX998_01885 ENOG4108WFR AraC Family Transcriptional Regulator FX998_01890 ENOG4105C26 Dehydrogenase FX998_01895 ENOG4105F11 amine oxidase FX998_01900 ENOG4105DXM phenylacetic acid degradation protein FX998_01905 ENOG4105CRS phenylacetate-CoA oxygenase PaaG subunit FX998_01910 ENOG4105N76 Phenylacetate-CoA oxygenase, subunit FX998_01915 ENOG4105D9S phenylacetate-CoA oxygenase PaaI subunit FX998_01920 ENOG4108ZA2 phenylacetate-CoA oxygenase PaaJ subunit FX998_01925 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) FX998_01930 ENOG4105E39 Enoyl-CoA hydratase FX998_01935 ENOG4108UKI Enoyl-CoA hydratase FX998_01940 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase FX998_01945 ENOG4108ZJI phenylacetic acid degradation protein FX998_01950 ENOG4105CHU acetyl-coa acetyltransferase FX998_01955 ENOG4105DZS Phenylacetate-CoA ligase FX998_01960 ENOG4105V9J phenylacetic acid degradation operon negative regulatory protein FX998_01965 ENOG4108Z0R Transferase FX998_01985 ENOG4107EF2 surface-exposed virulence protein FX998_01990 ENOG4107S5I aldo keto reductase FX998_02000 ENOG4108UMZ Cdp-alcohol phosphatidyltransferase FX998_02005 ENOG4108HPI phosphatidate Cytidylyltransferase FX998_02010 ENOG4105E8V Alpha Beta Hydrolase Fold protein FX998_02015 ENOG41077RS Phosphatase FX998_02025 ENOG4105CQ7 ATP-dependent helicase FX998_02030 ENOG4107DB1 DUF218 domain FX998_02035 ENOG4105C26 Dehydrogenase FX998_02045 ENOG4105CPW cytochrome b561 FX998_02050 ENOG4105UPP uncharacterized protein ydcA FX998_02055 ENOG4107NK6 Hok/gef family FX998_02060 ENOG4105C8Q Methyl-accepting chemotaxis FX998_02065 ENOG4105DDW LysR family Transcriptional regulator FX998_02070 ENOG4105E32 cytoplasmic protein FX998_02080 ENOG4105Z2P Protein of unknown function (DUF465) FX998_02085 ENOG4108Z9I -acetyltransferase FX998_02090 ENOG4107WE3 acetyltransferase YdcK FX998_02095 ENOG4108NKP c4-dicarboxylate transporter malic acid transport protein FX998_02100 ENOG41088CC tellurite resistance protein tehB FX998_02105 ENOG4108KKZ (LipO)protein FX998_02115 ENOG4105D7V transposase FX998_02120 ENOG4105DKK Benzoate FX998_02125 ENOG4108JCI Transcriptional regulator FX998_02130 ENOG4105CFP Peptidase U32 FX998_02135 ENOG4105RR0 Protein of unknown function (DUF2554) FX998_02145 ENOG4105PF0 Antitoxin component of a toxin-antitoxin (TA) module. Functions as an mRNA interferase antitoxin FX998_02150 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family FX998_02155 ENOG4107TYH extracellular solute-binding protein family 1 FX998_02160 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FX998_02165 ENOG4105D81 ABC transporter, permease FX998_02170 ENOG4105NRK Binding-protein-dependent transport systems, inner membrane component FX998_02185 ENOG410654E Membrane FX998_02190 ENOG4105R71 cytoplasmic protein FX998_02195 ENOG4108T9Y Inner membrane protein ydcZ FX998_02200 ENOG4108Z7F N-acetyltransferase FX998_02205 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein FX998_02210 ENOG4108WYP Transcriptional regulator FX998_02215 ENOG4105CHB tonB-dependent Receptor FX998_02220 ENOG4108NS2 receptor FX998_02225 ENOG4105C85 amino acid FX998_02230 ENOG4108N27 Glutathione S-transferase FX998_02240 ENOG4105CS6 Rhs element vgr protein FX998_02245 ENOG4105CNA YD repeat protein FX998_02265 ENOG410600T transposase FX998_02275 ENOG4108MEJ flavin reductase domain protein FX998_02280 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase FX998_02285 ENOG4105JAB phenazine biosynthesis protein, phzf family FX998_02290 ENOG4105D0D Nitrate reductase 2, gamma subunit FX998_02295 ENOG4108NZN Respiratory nitrate reductase 2 delta chain FX998_02300 ENOG4108IUE nitrate reductase beta subunit FX998_02310 ENOG4107QND Nitrite extrusion protein FX998_02330 ENOG4105RPH Inner membrane protein YddG FX998_02340 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein FX998_02345 ENOG4108MG3 formate dehydrogenase FX998_02350 ENOG41084S7 Plasmid maintenance system antidote protein FX998_02355 ENOG4105DQ4 alcohol dehydrogenase FX998_02365 ENOG4107AV5 Although this protein associates with the 30S subunit of the ribosome it is not considered to be a bona fide ribosomal protein FX998_02370 ENOG4105TPS biofilm-dependent modulation protein FX998_02375 ENOG4108Z9K Osmotically inducible protein FX998_02380 ENOG4107H6U ABC transporter FX998_02385 ENOG4105C3U ABC transporter FX998_02390 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FX998_02395 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component FX998_02400 ENOG4105DEF Extracellular solute-binding protein, family 5 FX998_02405 ENOG4108UQS dipeptidase FX998_02410 ENOG4105BZU Histidine kinase FX998_02415 ENOG4105BZU Histidine kinase FX998_02420 ENOG4105F32 YngK protein FX998_02425 ENOG4105E5D amino acid FX998_02430 ENOG4105CVK Glutamate decarboxylase FX998_02435 ENOG4107RAN Peptidase, M16 FX998_02440 ENOG4105PE1 Receptor FX998_02445 ENOG4105CQ0 ABC transporter FX998_02455 ENOG4105C4X radical SAM domain protein FX998_02460 ENOG4105ENH Sulfatase FX998_02465 ENOG4105Z68 AraC Family Transcriptional Regulator FX998_02475 ENOG4107QKC Oxidoreductase alpha (molybdopterin) subunit FX998_02480 ENOG4106PIH fimbrial-like protein ydeQ FX998_02485 ENOG4106318 fimbrial-like protein YdeR FX998_02490 ENOG4108WDE Fimbrial protein FX998_02505 ENOG4105CAF HipA N-terminal domain protein FX998_02510 ENOG41061P8 Persistence to inhibition of murein or DNA biosynthesis regulatory protein FX998_02525 ENOG4108EMV Catalyzes the phosphorylation of autoinducer 2 (AI-2) to phospho-AI-2, which subsequently inactivates the transcriptional regulator LsrR and leads to the transcription of the lsr operon. Phosphorylates the ring-open form of 4,5-dihydroxy-2,3- pentanedione (DPD), which is the precursor to all AI-2 signaling molecules, at the C5 position (By similarity) FX998_02530 ENOG4105DKT Transcriptional regulator FX998_02535 ENOG4105C2J ABC transporter FX998_02540 ENOG41071MT Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane FX998_02545 ENOG4105F5R ABC transporter FX998_02550 ENOG4105D4B ABC, transporter FX998_02555 ENOG41061GT Aldolase FX998_02560 ENOG4105K34 Involved in the degradation of phospho-AI-2, thereby terminating induction of the lsr operon and closing the AI-2 signaling cycle. Catalyzes the cleavage of phosphorylated 4,5- dihydroxy-2,3-pentanedione (P-DPD) to 2-phosphoglycolic acid (PG) and another three-carbon compound FX998_02570 ENOG4105FFC UPF0187 protein FX998_02575 ENOG4107QZW Altronate oxidoreductase FX998_02580 ENOG4105BZU Histidine kinase FX998_02585 ENOG4105M0C cytoplasmic protein FX998_02590 ENOG4105CSV Glutaminase FX998_02595 ENOG4105C26 Dehydrogenase FX998_02600 ENOG4105EGI Transcriptional regulator FX998_02620 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes FX998_02625 ENOG4108XW0 May be a transcriptional activator of genes involved in the multiple antibiotic resistance (Mar) phenotype. It can also activate genes such as sodA, zwf and micF FX998_02630 ENOG4106DNR multiple antibiotic resistance protein FX998_02635 ENOG4108594 Permease of the drug metabolite transporter FX998_02640 ENOG4105E5W Transporter FX998_02650 ENOG4105FSR swimming returnes to normal when residues 206-207 are both mutated to Ala. Overexpression also leads to a reduction in flagellar abundance and a 20-fold increase in c-di- GMP levels in vivo. Required for aminoglycoside-mediated induction of biofilm formation, it also plays a lesser role in biofilm production in response to other classes of translation inhibitors. The c-di-GMP produced by this enzyme up-regulates poly-GlcNAc production as well as the biofilm synthesis protein PgaD, although c-di-GMP is probably not the main inducing principle. Cyclic-di- GMP is a second messenger which controls cell surface-associated traits in bacteria FX998_02655 ENOG4108YDI single-species biofilm formation on inanimate substrate FX998_02660 ENOG4108WTK competence damage-inducible protein FX998_02665 ENOG4105DGW oligopeptidase A FX998_02670 ENOG4105EMU Dehydrogenase FX998_02675 ENOG4107XBN GntR Family Transcriptional Regulator FX998_02680 ENOG41061EV selenium-binding protein YdfZ FX998_02685 ENOG4105DEI Mannitol dehydrogenase FX998_02695 ENOG4105CPQ Dehydrogenase FX998_02700 ENOG4105CXK mandelate racemase muconate lactonizing FX998_02715 ENOG4108MK9 spermidine N(1)-acetyltransferase FX998_02725 ENOG4105KBG Protein of unknown function (DUF1161) FX998_02730 ENOG4107QY8 reductase FX998_02735 ENOG4105C3J Cysteine desulfurase FX998_02740 ENOG4105QAX Iron-sulfur FX998_02745 ENOG4107KGK dmso reductase anchor subunit FX998_02750 ENOG4108NEM leader-binding protein dmsD FX998_02760 ENOG4105EWW Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) FX998_02765 ENOG4105DAG ROK family FX998_02770 ENOG4106NZI LysR family Transcriptional regulator FX998_02775 ENOG4105D94 Major Facilitator Superfamily FX998_02790 ENOG4105CVW peptidase s1 and s6 chymotrypsin hap FX998_02810 ENOG4105DSF transport protein FX998_02815 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) FX998_02820 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) FX998_02825 ENOG4105C5D exported protein FX998_02830 ENOG4105D5Q Arginine ornithine antiporter FX998_02835 ENOG410642E Short chain dehydrogenase FX998_02840 ENOG4105RA2 Membrane FX998_02845 ENOG4107EXC regulatoR FX998_02850 ENOG4105JJR Histidine kinase FX998_02860 ENOG4105C9Q fumarate hydratase class II FX998_02865 ENOG4107GFK fumarate FX998_02870 ENOG4105EIP mannose-6-phosphate isomerase FX998_02875 ENOG4106J39 exported protein FX998_02880 ENOG4108QNI outer membrane porin protein FX998_02885 ENOG4105CT4 transporter FX998_02890 ENOG4105CNT hydrolase family 2 FX998_02895 ENOG4105XEA Tetr family transcriptional regulator FX998_02900 ENOG4107ZQV short-chain dehydrogenase reductase FX998_02905 ENOG4107P2S Transcriptional regulator FX998_02910 ENOG4105CI1 PTS System FX998_02915 ENOG4105C87 Aminotransferase class I and II FX998_02925 ENOG4105D9R oxidoreductase FX998_02930 ENOG4106C6R beta-lactam resistance protein FX998_02935 ENOG4105QZ5 OriC-binding nucleoid-associated protein FX998_02940 ENOG4105M9B inner membrane protein ydgK FX998_02965 ENOG4108UQQ Electron transport complex FX998_02975 ENOG4105CSM endonuclease III FX998_02980 ENOG4105DUX Transporter FX998_02985 ENOG4108K3A Glutathione S-transferase FX998_02990 ENOG4107XGF functions in a salvage pathway. Uses pyridoxamine (By similarity) FX998_03005 ENOG410642K Lysozyme inhibitor FX998_03015 ENOG4108XTF Outer Membrane Lipoprotein FX998_03030 ENOG4105Y49 secretion protein, HlyD family FX998_03035 ENOG4105DSW Fusaric acid resistance protein FX998_03040 ENOG4108Z7T Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) FX998_03045 ENOG4107RGM aldo keto reductase FX998_03050 ENOG4105XZD Fe-S protein FX998_03055 ENOG4108WUH Transcriptional regulator, TetR family FX998_03060 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase FX998_03065 ENOG4108UYE Lactoylglutathione lyase FX998_03070 ENOG4105DH5 Responsible for the end-turnover of tRNA specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis (By similarity) FX998_03075 ENOG4107QRT dEAD DEAH box helicase FX998_03080 ENOG4105M2J Glutaredoxin FX998_03085 ENOG4105K4H Nlp p60 protein FX998_03090 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) FX998_03095 ENOG4105F27 Major Facilitator FX998_03110 ENOG4105F52 Transcriptional regulator FX998_03115 ENOG4105CZQ inner membrane transport protein YdhC FX998_03120 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase FX998_03125 ENOG4108R6K riboflavin synthase, subunit alpha FX998_03150 ENOG4105N0V mono-oxygenase ydhR FX998_03155 ENOG4108KTU conserved protein with FAD NAD(P)-binding domain FX998_03160 ENOG4108Y7C Conserved Protein FX998_03165 ENOG4108NWD Cytochrome FX998_03170 ENOG4108393 oxidoreductase Fe-S subunit FX998_03175 ENOG4105JVW FX998_03180 ENOG4105WE2 aldehyde ferredoxin oxidoreductase FX998_03185 ENOG4108PU5 4fe-4S ferredoxin, iron-sulfur binding domain protein FX998_03190 ENOG4105RFR Protein of unknown function (DUF2767) FX998_03195 ENOG4105CA9 Pyruvate kinase FX998_03200 ENOG4105KMX major outer membrane lipoprotein FX998_03205 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein FX998_03220 ENOG4105JRK feS assembly protein SufD FX998_03225 ENOG4105C3K feS assembly ATPase SufC FX998_03230 ENOG4105DIW FeS assembly protein SUFB FX998_03235 ENOG4108Z4V iron-sulfur cluster assembly FX998_03240 ENOG410671Z uncharacterized protein ydiH FX998_03245 ENOG4105KA0 thioesterase Superfamily protein FX998_03250 ENOG4105CQB FAD linked oxidase domain protein FX998_03255 ENOG4105IPI Membrane FX998_03265 ENOG4105SUA Ydil protein FX998_03270 ENOG4105EMV Major Facilitator FX998_03275 ENOG4105EMV Major Facilitator FX998_03290 ENOG4107R0K CoA transferase having broad substrate specificity for short-chain acyl-CoA thioesters with the activity decreasing when the length of the carboxylic acid chain exceeds four carbons (By similarity) FX998_03295 ENOG4105C1G acyl-Coa dehydrogenase FX998_03300 ENOG4105W4W Transcriptional regulator FX998_03305 ENOG4105CV7 Electron transfer flavoprotein FX998_03310 ENOG4105C10 Electron transfer flavoprotein FX998_03315 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase FX998_03320 ENOG41090P5 ferredoxin-like protein FX998_03325 ENOG4105CEY Amp-dependent synthetase and ligase FX998_03330 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) FX998_03340 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) FX998_03345 ENOG4106EDX Hemin uptake protein FX998_03355 ENOG4108TC0 Diguanylate phosphodiesterase FX998_03360 ENOG4108QBX (LipO)protein FX998_03370 ENOG4108V06 Glutathione peroxidase FX998_03385 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) FX998_03400 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) FX998_03405 ENOG41082NX 50s ribosomal protein l35 FX998_03430 ENOG4108NE3 Salt-induced outer membrane protein FX998_03435 ENOG4105DE4 1-phosphofructokinase FX998_03440 ENOG4105P10 Uncharacterized protein ydiZ FX998_03445 ENOG4105FGM Fructosamine kinase FX998_03450 ENOG4107PN8 YfeABCD locus regulator FX998_03455 ENOG4107UW8 HAD-superfamily hydrolase subfamily IA variant 3 FX998_03460 ENOG4107K5X Membrane-bound metal-dependent hydrolase FX998_03465 ENOG4108ETY sodium dicarboxylate symporter FX998_03480 ENOG4105CH6 catalase FX998_03490 ENOG4105F8D glycoside hydrolase family 4 FX998_03495 ENOG4105EZV Transcriptional regulator FX998_03500 ENOG4105VCP PTS System FX998_03505 ENOG4105CK1 PTS System FX998_03510 ENOG4105VZJ PTS System FX998_03515 ENOG4105KKI DNA-binding transcriptional activator OsmE FX998_03525 ENOG4105DKD Incises the DNA at the 3' side of a lesion during nucleotide excision repair. Incises the DNA farther away from the lesion than UvrC. Not able to incise the 5' site of a lesion. When a lesion remains because UvrC is not able to induce the 3' incision, Cho incises the DNA. Then UvrC makes the 5' incision. The combined action of Cho and UvrC broadens the substrate range of nucleotide excision repair (By similarity) FX998_03535 ENOG4108SPG Periplasmic Protein FX998_03555 ENOG4105F4X arginine FX998_03565 ENOG4105CGK Exodeoxyribonuclease III FX998_03570 ENOG4108RSN SNARE associated Golgi FX998_03575 ENOG4108KCW iron-sulfur cluster binding FX998_03580 ENOG4108N5C SNARE associated Golgi protein-related protein FX998_03585 ENOG4107ZN8 Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) FX998_03590 ENOG4105VNH ABC transporter solute-binding protein FX998_03595 ENOG4105CXZ ABC transporter, permease FX998_03600 ENOG4108VGW abc transporter atp-binding protein FX998_03605 ENOG4107RM6 sulfurtransferase FX998_03610 ENOG4108T9J Cdp-alcohol phosphatidyltransferase FX998_03615 ENOG4105M6F mutator MutT protein FX998_03620 ENOG4105MTM Protein of unknown function (DUF1496) FX998_03625 ENOG4105D82 Glutamate dehydrogenase FX998_03630 ENOG41065FB inner membrane protein ynji FX998_03635 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) FX998_03645 ENOG41069NU Nitroreductase FX998_03650 ENOG4105D07 Signal peptide peptidase, SppA FX998_03655 ENOG4105HDK L-asparaginase FX998_03660 ENOG4108RWI nicotinamidase FX998_03665 ENOG4108KUU Inner membrane metabolite transport protein ydjE FX998_03670 ENOG4105E98 transcriptional regulator DeoR family FX998_03675 ENOG4105CPC Aldo Keto reductase FX998_03680 ENOG4107UH8 sugar kinase FX998_03685 ENOG4105D2N Aldolase FX998_03690 ENOG4105CPQ Dehydrogenase FX998_03695 ENOG4107TE1 transport protein FX998_03700 ENOG4105CPQ Dehydrogenase FX998_03705 ENOG4105VUT cytoplasmic protein FX998_03715 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase FX998_03720 ENOG4105DSB aldose 1-epimerase FX998_03725 ENOG4105CV8 reductase FX998_03730 ENOG4105GNX MltA-interacting MipA family protein FX998_03735 ENOG4105CYN Serine protein kinase FX998_03745 ENOG4106KTS Inner membrane protein yeaI FX998_03750 ENOG4108KHP Diguanylate cyclase FX998_03755 ENOG4108KXH Ybak prolyl-tRNA synthetase associated FX998_03770 ENOG4105R1U AraC Family Transcriptional Regulator FX998_03775 ENOG4105DJ2 Major Facilitator Superfamily FX998_03780 ENOG4105K78 MarR family Transcriptional regulator FX998_03785 ENOG4105UCG Domain of unknown function (DUF333) FX998_03790 ENOG410620I Diguanylate cyclase FX998_03795 ENOG4106G4W FX998_03805 ENOG4105Y3U Transglycosylase-associated protein FX998_03810 ENOG4105YP6 Domain of unknown function (DUF1869) FX998_03815 ENOG4108YS1 cytoplasmic protein FX998_03825 ENOG4105EJC lysr family transcriptional regulator FX998_03830 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) FX998_03835 ENOG4105C94 Transporter FX998_03840 ENOG4105DVW rieske (2Fe-2S) FX998_03845 ENOG4105E3J oxidoreductase FX998_03850 ENOG4105ZIE Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity) FX998_03855 ENOG4105CEY Amp-dependent synthetase and ligase FX998_03860 ENOG4105Y4Z Outer Membrane Lipoprotein FX998_03865 ENOG41072GX Peptidase M22 Glycoprotease FX998_03870 ENOG4105DVT helicase FX998_03875 ENOG4105M4H endoribonuclease L-psp FX998_03880 ENOG4105V2F Uncharacterized protein yoac FX998_03890 ENOG4105CRQ synthase (Component I) FX998_03900 ENOG4105EJQ L-serine dehydratase FX998_03905 ENOG4107XTP (EAL) domain protein FX998_03910 ENOG4105EE5 Membrane protein terC FX998_03915 ENOG4108EQA pts system FX998_03920 ENOG4105ETZ PTS System FX998_03925 ENOG4105F3R pts system mannose fructose sorbose family iid FX998_03940 ENOG4105DHI Methyltransferase FX998_03945 ENOG4105VEQ Cold shock protein FX998_03950 ENOG410610J Protein of unknown function (DUF2627) FX998_03955 ENOG4105Q3Y exported protein FX998_03965 ENOG4105TIK FX998_03970 ENOG4105J4Q Transcriptional regulator FX998_03975 ENOG4105C0R drug resistance transporter emrb qaca subfamily FX998_03985 ENOG4105CN1 protease FX998_03995 ENOG4108ZGC gaf domain protein FX998_04000 ENOG4105H2K paraquat-inducible protein a FX998_04005 ENOG4105DY2 Paraquat-inducible protein b FX998_04015 ENOG4105WT8 Protein of unknown function (DUF1480) FX998_04020 ENOG4105UVW uncharacterized protein yebW FX998_04025 ENOG4108R1E Serine threonine protein phosphatase 1 FX998_04030 ENOG4105NKT exported protein FX998_04035 ENOG4108PNC copper resistance FX998_04040 ENOG4105FXM Copper resistance protein FX998_04045 ENOG4105MPK DNA polymerase III subunit theta FX998_04050 ENOG4108YGA nitrilase cyanide hydratase and apolipoprotein n-acyltransferase FX998_04055 ENOG4105UMD exodeoxyribonuclease X FX998_04060 ENOG4105CUG Oligopeptidase b FX998_04065 ENOG4108Q2J Inner membrane protein YebE FX998_04070 ENOG4105RSZ secreted protein FX998_04075 ENOG4105X2V dna damage-inducible protein FX998_04085 ENOG4108UHU Aldolase FX998_04090 ENOG4105C01 Dihydroxy-acid dehydratase FX998_04095 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase FX998_04100 ENOG4106KNT transcriptional regulator FX998_04105 ENOG4105CA9 Pyruvate kinase FX998_04110 ENOG4105NWR lipid A biosynthesis (Kdo)2-(Lauroyl)-lipid IVA acyltransferase FX998_04115 ENOG4105DR5 peptidase FX998_04120 ENOG4105NXV High-affinity zinc uptake system protein FX998_04125 ENOG4105FDK ABC transporter FX998_04130 ENOG4105FAV ABC, transporter FX998_04150 ENOG4107S01 Repressor protein MetJ FX998_04160 ENOG4105CDY transcriptional regulatory protein FX998_04165 ENOG4108TIT dATP pyrophosphohydrolase FX998_04175 ENOG4105D3W isochorismatase FX998_04180 ENOG41081XQ Conserved Protein FX998_04185 ENOG4105WJG Glutathione FX998_04200 ENOG4107QY8 reductase FX998_04205 ENOG4105CUW cytochrome C-TYPE protein FX998_04215 ENOG4106ZCM YecM protein FX998_04230 ENOG4105W13 flagellar protein FX998_04235 ENOG4105D7B Flagellar biosynthesis protein flha FX998_04240 ENOG4105D00 flagellar biosynthetic protein flhB FX998_04245 ENOG4108KCC Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P) (By similarity) FX998_04250 ENOG4108VYJ response regulator receiver protein FX998_04255 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) FX998_04260 ENOG4105BZU Histidine kinase FX998_04265 ENOG4105C8Q Methyl-accepting chemotaxis FX998_04270 ENOG4105C8Q Methyl-accepting chemotaxis FX998_04275 ENOG4108V3W Chemotaxis protein, CheW FX998_04280 ENOG4105CBS Chea signal transduction histidine kinase FX998_04285 ENOG4105ER2 Ompa motb domain protein FX998_04290 ENOG4107RD7 Flagellar Motor Protein, MotA FX998_04295 ENOG4106CIA Functions in complex with FlhD as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region FX998_04305 ENOG4108VA4 Universal stress protein FX998_04315 ENOG4108K4C ec 3.1.3.12 FX998_04320 ENOG4105CNN ABC, transporter FX998_04325 ENOG4105C2J ABC transporter FX998_04330 ENOG4105DMK Periplasmic binding protein LacI transcriptional regulator FX998_04335 ENOG4108UEC Ferritin-like protein FX998_04340 ENOG4105N4N Protein of unknown function (DUF2766) FX998_04350 ENOG4105P23 (LipO)protein FX998_04355 ENOG41090A1 ferritin FX998_04360 ENOG4105VVZ metal-binding protein FX998_04365 ENOG4105E0U tyrosine-specific transport protein FX998_04370 ENOG4106RHG Yeca family FX998_04390 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase FX998_04400 ENOG4105WH1 Two component transcriptional regulator luxr family FX998_04415 ENOG4105XVG cytoplasmic protein FX998_04420 ENOG4105VJY transcriptional regulator FX998_04425 ENOG4105CDA abc transporter atp-binding protein FX998_04430 ENOG4105E5Q amino acid AbC transporter FX998_04440 ENOG4105EAB amino acid AbC transporter FX998_04445 ENOG4108M9K flagella biosynthesis protein FliZ FX998_04450 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FX998_04455 ENOG4105I03 Flagellin FX998_04460 ENOG4105DTS flagellar hook-associated FX998_04465 ENOG4105MQ3 flagellar protein FliS FX998_04470 ENOG4105YXP it directly binds FlhC, thus inhibiting the binding of the FlhC FlhD complex to class 2 promoters, resulting in decreased expression of class 2 flagellar operons. As a chaperone, effects FliD transition to the membrane by preventing its premature polymerization, and by directing it to the export apparatus (By similarity) FX998_04475 ENOG4105E5K Alpha-amylase FX998_04480 ENOG4108W9D (LipO)protein FX998_04485 ENOG41066VF YeeE YedE family protein FX998_04490 ENOG4105KSU Redox protein FX998_04495 ENOG4108RAV Conserved protein FX998_04520 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) FX998_04525 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) FX998_04530 ENOG41090PJ Flagellar assembly protein FX998_04540 ENOG4105GSA Flagellar export protein flij FX998_04545 ENOG4105WF4 Flagellar hook-length control protein FX998_04550 ENOG4107ZI8 flagellar basal body-associated protein flil FX998_04555 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) FX998_04560 ENOG4105DD5 Flagellar motor switch protein FX998_04565 ENOG4105K0P flagellar biosynthesis protein FX998_04570 ENOG4105CN7 Flagellar biosynthetic protein FliP FX998_04575 ENOG4105VS8 Flagellar biosynthetic protein fliq FX998_04580 ENOG4105D19 Role in flagellar biosynthesis (By similarity) FX998_04585 ENOG4107TKS colanic acid capsular biosynthesis activation protein A FX998_04595 ENOG4105YX3 cellular response to acidity FX998_04610 ENOG4105VNZ cytoplasmic protein FX998_04615 ENOG4105CKW Inner membrane protein yedI FX998_04620 ENOG4105FDR Membrane FX998_04625 ENOG41090BB DNA mismatch endonuclease (vsr) FX998_04630 ENOG4105DVF Cytosine-specific methyltransferase FX998_04635 ENOG4105EST Metal Dependent Phosphohydrolase FX998_04640 ENOG4105Y0K Inner membrane protein YedR FX998_04645 ENOG4105ZIT Porin Gram-negative type FX998_04660 ENOG4107ZY3 Histidine kinase FX998_04665 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FX998_04670 ENOG4105VT2 5-hydroxyisourate hydrolase FX998_04685 ENOG4108MEK Metal-binding protein YodA FX998_04690 ENOG4108VKM cytochrome b561 FX998_04720 ENOG4105EYM Major Facilitator superfamily FX998_04725 ENOG4105BZ1 (ABC) transporter FX998_04740 ENOG4105C0W non-ribosomal peptide synthetase FX998_04760 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase FX998_04765 ENOG4107ZSV Receptor FX998_04845 ENOG4108PCE TRANSFER protein FX998_04930 ENOG4105CVR type I restriction-modification system FX998_04950 ENOG4105CSH Transporter FX998_04955 ENOG4105FYV Amp nucleosidase FX998_04960 ENOG4105CDY transcriptional regulatory protein FX998_04970 ENOG4105UQX Mate efflux family protein FX998_04980 ENOG4107R11 Transcriptional regulator FX998_04985 ENOG4106P55 Transcriptional regulator FX998_04995 ENOG4108PXI ErfK YbiS YcfS YnhG FX998_05010 ENOG4108YZT Adenosylcobinamide kinase FX998_05025 ENOG41080QX K07048 phosphotriesterase-related protein FX998_05070 ENOG4105KF5 hemolysin expression-modulating protein FX998_05115 ENOG4105F4K antigen 43 FX998_05130 ENOG4106H6R UPF0380 protein FX998_05140 ENOG4105MFG Antirestriction protein FX998_05145 ENOG4108YGG dna repair protein FX998_05150 ENOG4105D70 Integrase catalytic subunit FX998_05155 ENOG4105F5W AtP-binding protein FX998_05160 ENOG4108YGG dna repair protein FX998_05165 ENOG4106WJE Protein of unknown function (DUF987) FX998_05170 ENOG4105MAW Antitoxin component of a toxin-antitoxin (TA) module. Labile antitoxin that counteracts the effect of the CbtA (YeeV) toxin. It does not bind to the cognate toxin but instead binds to MreB and FtsZ (the toxin targets), enhancing their polymerization by forming higher-order bundles FX998_05210 ENOG4105DR8 Membrane FX998_05215 ENOG4108S5C Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell (By similarity) FX998_05220 ENOG4105DZ1 carboxypeptidase FX998_05225 ENOG4105CJB Exodeoxyribonuclease I FX998_05235 ENOG4105CUC YeeE YedE family protein FX998_05240 ENOG4105CUB amino acid FX998_05250 ENOG4105EQ1 Transcriptional regulator FX998_05255 ENOG4108535 NAD dependent epimerase/dehydratase family FX998_05260 ENOG4105KRQ Addiction module toxin, Txe YoeB family FX998_05265 ENOG4105VTW prevent-host-death family FX998_05290 ENOG4105ECC imidazole-glycerol-phosphate dehydratase FX998_05295 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) FX998_05310 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase FX998_05320 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) FX998_05330 ENOG4108KQJ Type 11 methyltransferase FX998_05365 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase FX998_05370 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase FX998_05380 ENOG4105C1B dTDP-glucose 4-6-dehydratase FX998_05385 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) FX998_05390 ENOG4108UW5 maltose o-acetyltransferase FX998_05430 ENOG4108KBE Glycosyl transferase, family 2 FX998_05445 ENOG4105DAY polysaccharide export protein FX998_05450 ENOG4108MRJ FX998_05455 ENOG4105MH5 phosphoesterase PA-phosphatase related protein FX998_05460 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase FX998_05465 ENOG4105EE5 Membrane protein terC FX998_05480 ENOG4108GAE asmA family FX998_05490 ENOG4105DBI uridine monophosphokinase FX998_05495 ENOG4105BZU Histidine kinase FX998_05500 ENOG4105D03 DNA-3-methyladenine glycosylase II FX998_05505 ENOG4105R8A Heat shock protein FX998_05515 ENOG4105UM3 Inherit from NOG: serine threonine phosphoprotein phosphatase FX998_05520 ENOG4108M24 von Willebrand factor, type A FX998_05560 ENOG4105EB3 Histidine kinase FX998_05565 ENOG4105E3W Two component transcriptional regulator (Winged helix family FX998_05570 ENOG4105KWI UPF0339 protein FX998_05575 ENOG4105X54 addiction module antidote protein FX998_05585 ENOG4105CFP Peptidase U32 FX998_05595 ENOG41076Z6 Uncharacterized protein yegR FX998_05610 ENOG4107WTH Galactitol-1-phosphate dehydrogenase FX998_05615 ENOG4105DT3 PTS system, galactitol-specific IIc component FX998_05620 ENOG41090UW PTS System FX998_05625 ENOG41082GB PTS system galactitol-specific transporter subunit IIA FX998_05640 ENOG4105EIE fructose-bisphosphate aldolase FX998_05645 ENOG4105EAA nucleoside FX998_05650 ENOG4108KD5 ADP-ribosylation crystallin J1 FX998_05655 ENOG4108TFM Kinase, PfkB family FX998_05660 ENOG4105FDP GntR family transcriptional regulator FX998_05665 ENOG4108UQ1 hydrolase, family 25 FX998_05670 ENOG4105DWF phosphomethylpyrimidine kinase FX998_05675 ENOG4105C4U 4-methyl-5-beta-hydroxyethylthiazole kinase FX998_05685 ENOG41061MD high-affinity nickel-transporter FX998_05690 ENOG4108Z1S Influences nickel and cobalt homeostasis. May act by modulating RcnA-mediated export of these ions to avoid excess efflux. Not involved in nickel import and does not bind nickel or cobalt ions directly FX998_05695 ENOG410662B Type-1 fimbrial protein FX998_05700 ENOG4105CW0 outer membrane usher protein FX998_05705 ENOG4108MQF Chaperone FX998_05710 ENOG41063W2 Fimbrial protein FX998_05715 ENOG41067AK Protein of unknown function (DUF2574) FX998_05720 ENOG4105D1F ATP-binding protein FX998_05730 ENOG4108KDT Molybdate metabolism regulator FX998_05735 ENOG4108KDT Molybdate metabolism regulator FX998_05740 ENOG4108KDT Molybdate metabolism regulator FX998_05760 ENOG4105DEG Vwa containing coxe family protein FX998_05765 ENOG410903U zinc ion binding FX998_05770 ENOG4108YCW (LipO)protein FX998_05775 ENOG4108W15 Protein of unknown function (DUF1456) FX998_05780 ENOG4108NEV two component transcriptional regulator, LytTR family FX998_05785 ENOG4108HRK Histidine kinase FX998_05790 ENOG4108XDN Transcriptional regulator FX998_05800 ENOG4105WJV Binding-protein-dependent transport systems, inner membrane component FX998_05805 ENOG4108IJ8 ABC transporter FX998_05810 ENOG4107T5X Binding-protein-dependent transport systems, inner membrane component FX998_05815 ENOG4107SI7 Substrate-binding region of abc-type glycine betaine transport system FX998_05820 ENOG4107QK4 glycoside hydrolase, family 3 domain protein FX998_05825 ENOG4105CXG d-lactate dehydrogenase FX998_05830 ENOG41061WM D-Alanyl-D-Alanine FX998_05835 ENOG41069YE inner membrane protein yohC FX998_05840 ENOG4105KHU inner membrane protein YohD FX998_05845 ENOG4105H9W Short-chain dehydrogenase reductase Sdr FX998_05850 ENOG4105ETP RND efflux system, outer membrane lipoprotein FX998_05860 ENOG4105FBT Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity) FX998_05870 ENOG41067MG lrgb family FX998_05880 ENOG4107GZ4 SanA protein FX998_05885 ENOG4105Y9N Membrane FX998_05890 ENOG4105BZ8 glutamate synthase FX998_05895 ENOG4107SJI Dehydrogenase FX998_05900 ENOG4108HWV )-transporter FX998_05905 ENOG4105C2J ABC transporter FX998_05910 ENOG4105EMA Periplasmic binding protein LacI transcriptional regulator FX998_05915 ENOG41060NJ transcriptional regulator FX998_05920 ENOG4105DHF Membrane FX998_05940 ENOG4108IQI permease FX998_05945 ENOG4105DUM transcriptional regulator, lysR family FX998_05950 ENOG4105HMI Membrane FX998_05960 ENOG4105DD7 kinase (PfkB family FX998_05965 ENOG4105D9N nucleoside FX998_05975 ENOG4108Y4K DNA-binding transcriptional activator FX998_05980 ENOG4105D9N nucleoside FX998_05985 ENOG4105D53 Catalyzes the hydrolysis of pseudouridine 5'-phosphate (PsiMP) to ribose 5-phosphate and uracil (By similarity) FX998_05990 ENOG4105DD7 kinase (PfkB family FX998_05995 ENOG4105DM4 PTS System FX998_06000 ENOG4105DE4 1-phosphofructokinase FX998_06005 ENOG4105DTZ bifunctional PTS system fructose-specific transporter subunit IIA HPr protein FX998_06010 ENOG4105S8Q sugar efflux transporter FX998_06015 ENOG4105KRS Proteinase inhibitor FX998_06025 ENOG4105DEI Mannitol dehydrogenase FX998_06030 ENOG4105CKI cobalamin synthesis protein FX998_06035 ENOG41076MN Phosphoesterase, PA-phosphatase related FX998_06040 ENOG4107TT5 NLP P60 protein FX998_06045 ENOG4105CXC rtn protein FX998_06050 ENOG4105E43 Extracellular solute-binding protein, family 5 FX998_06055 ENOG4108I5X binding-protein-dependent transport systems inner membrane Component FX998_06060 ENOG4108IYQ Binding-protein-dependent transport systems inner membrane component FX998_06065 ENOG4108JQ5 ABC transporter FX998_06070 ENOG4105HG6 FX998_06075 ENOG4105C2C drug resistance transporter, Bcr CflA FX998_06080 ENOG4105I08 Pseudouridine synthase FX998_06085 ENOG4105CFI type iii restriction protein res subunit FX998_06105 ENOG4105E68 Sulfatase FX998_06135 ENOG4105UZW Tail fiber assembly protein FX998_06140 ENOG4108X9F tail fiber protein FX998_06215 ENOG4105IM0 capsid protein FX998_06225 ENOG4105F7J membrane-bound serine protease FX998_06235 ENOG4107DE1 head-to-tail joining protein FX998_06240 ENOG4105UZW Tail fiber assembly protein FX998_06245 ENOG4105FKG DNA packaging protein FX998_06255 ENOG4106YSC FX998_06260 ENOG41064WM Uncharacterized protein YcgX FX998_06280 ENOG4105KUS lysozyme FX998_06285 ENOG4105QFS Lysis protein S homolog from lambdoid prophage FX998_06290 ENOG4107QMH DNA methylase FX998_06305 ENOG4105HGD Antitermination protein FX998_06310 ENOG4108MXB Protein of unknown function (DUF968) FX998_06320 ENOG4106CZA Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC (By similarity) FX998_06325 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) FX998_06340 ENOG4105YQ0 FX998_06350 ENOG4108S1U FX998_06385 ENOG4105H40 FX998_06390 ENOG4108HJ1 Uncharacterized conserved protein (DUF2303) FX998_06395 ENOG4108R7K Metal Dependent Phosphohydrolase FX998_06400 ENOG41077V0 CPS-53 (KpLE1) prophage FX998_06435 ENOG4108MGN ATP-binding component of a transport system FX998_06440 ENOG4105WH1 Two component transcriptional regulator luxr family FX998_06445 ENOG4105KWW Biogenesis protein FX998_06450 ENOG4107QX9 Thiol disulfide interChange protein FX998_06455 ENOG4105DA4 cytochrome c-type biogenesis protein FX998_06465 ENOG4105X3C heme exporter protein FX998_06470 ENOG41060IM Heme exporter protein FX998_06475 ENOG4105CA5 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes (By similarity) FX998_06480 ENOG4107EV4 once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system (By similarity) FX998_06485 ENOG4105CUW cytochrome C-TYPE protein FX998_06490 ENOG4108ZMS Electron transfer subunit of the periplasmic nitrate reductase complex NapAB (By similarity) FX998_06495 ENOG4105GXZ Ferredoxin-type protein NapH FX998_06500 ENOG4108BGM Quinol dehydrogenase periplasmic component FX998_06510 ENOG41061Q0 Assembly protein for periplasmic nitrate reductase FX998_06515 ENOG4108ZNS ferredoxin-type protein NapF FX998_06530 ENOG4105IBP Cyclic peptide transporter FX998_06535 ENOG4105CF1 Alkylated DNA repair protein FX998_06540 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) FX998_06545 ENOG4105CJ2 (LipO)protein FX998_06550 ENOG4105FCK Membrane FX998_06555 ENOG4105E3G Phosphotransfer intermediate protein in two-component regulatory system with RcsBC FX998_06560 ENOG41068CG regulatoR FX998_06565 ENOG4105BZU Histidine kinase FX998_06570 ENOG4105BZU Histidine kinase FX998_06575 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family FX998_06580 ENOG4107QP7 CoA-transferase subunit A FX998_06585 ENOG4107QNJ CoA-transferase subunit B FX998_06590 ENOG4105CRW Short chain fatty acid transporter FX998_06595 ENOG4105CHU acetyl-coa acetyltransferase FX998_06600 ENOG4105EDV vault protein FX998_06605 ENOG41081SK signal peptide protein FX998_06610 ENOG4107S52 alpha-2-macroglobulin domain protein FX998_06615 ENOG4108QJJ Protein of unknown function (DUF1175) FX998_06620 ENOG4107FKF Uncharacterized protein conserved in bacteria (DUF2138) FX998_06625 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) FX998_06635 ENOG4107GHC outer membrane autotransporter FX998_06640 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) FX998_06645 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) FX998_06650 ENOG4105XPH Ferredoxin FX998_06655 ENOG4105FQR PH-inducible protein involved in stress response FX998_06665 ENOG4106MZZ glycerophosphoryl diester phosphodiesterase FX998_06670 ENOG4105CXY transporter FX998_06675 ENOG4107R5Y anaerobic glycerol-3-phosphate dehydrogenase, subunit A FX998_06685 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) FX998_06690 ENOG4105DNE Transposase FX998_06705 ENOG4105CSP Major Facilitator Superfamily FX998_06725 ENOG4108UII YfaZ family FX998_06755 ENOG4105F73 Catalyzes the deformylation of 4-deoxy-4-formamido-L- arabinose-phosphoundecaprenol to 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity) FX998_06760 ENOG4105SA9 Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity) FX998_06770 ENOG4105U65 Translocates 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol (alpha-L-Ara4N-phosphoundecaprenol) from the cytoplasmic to the periplasmic side of the inner membrane (By similarity) FX998_06775 ENOG4106GZG polymyxin resistance protein B FX998_06780 ENOG4105CEY Amp-dependent synthetase and ligase FX998_06790 ENOG4108IPT Naphthoate synthase FX998_06805 ENOG4105E4F Isochorismate synthase FX998_06810 ENOG4105TNS Conserved Protein FX998_06815 ENOG4107YB6 acetyltransferase, (GNAT) family FX998_06825 ENOG4105Z6G Protease that can act as an efficient and specific deubiquitinating enzyme in vitro. Does not possess desumoylating and deneddylating activities. The physiological substrate is FX998_06830 ENOG4105CP2 von willebrand factor, type a FX998_06835 ENOG4107VAM peptidase, m28 FX998_06840 ENOG4105GDX Domain of unknown function (DUF1877) FX998_06845 ENOG4105ZD8 FX998_06850 ENOG4106EES FX998_06855 ENOG4106HDC FX998_06865 ENOG4105C8S subunit m FX998_06870 ENOG4105D65 subunit l FX998_06875 ENOG41080EA NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) FX998_06880 ENOG4107UFS subunit j FX998_06885 ENOG4105P3U NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) FX998_06895 ENOG4107R0R NADH dehydrogenase subunit g FX998_06900 ENOG4107QIZ NADH dehydrogenase FX998_06905 ENOG4105GKE subunit e FX998_06910 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) FX998_06925 ENOG4107NQ8 LysR family Transcriptional regulator FX998_06930 ENOG4105CHM Aminotransferase FX998_06940 ENOG4107QWE )-transporter FX998_06945 ENOG4105EVE HAD-superfamily hydrolase subfamily IA variant 3 FX998_06960 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) FX998_06965 ENOG4105C6K Malic enzyme FX998_06970 ENOG4105CSX c4-dicarboxylate anaerobic carrier FX998_06975 ENOG4105PTV Nudix Hydrolase FX998_06980 ENOG4108RE9 Phosphodiesterase FX998_06985 ENOG4108SHQ Glutathione S-transferase FX998_06990 ENOG4105CYM Glutathione S-transferase FX998_06995 ENOG4105KKP D-erythro-7,8-dihydroneopterin triphosphate 2'-epimerase FX998_07000 ENOG4105ECP epimerase FX998_07005 ENOG4105DNE Transposase FX998_07010 ENOG4108JEH abc transporter atp-binding protein FX998_07015 ENOG4106YG3 ABC transporter FX998_07020 ENOG4105DSP amino acid AbC transporter FX998_07025 ENOG4105E89 ABC transporter FX998_07030 ENOG4105E89 ABC transporter FX998_07035 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase FX998_07040 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase FX998_07045 ENOG4105E96 Colicin v production protein FX998_07050 ENOG4108S3P Sporulation domain protein FX998_07055 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase FX998_07065 ENOG4105DQR SNARE associated Golgi FX998_07075 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) FX998_07080 ENOG4105CJ0 Catalyzes the oxidation of erythronate-4-phosphate to 3- hydroxy-2-oxo-4-phosphonooxybutanoate (By similarity) FX998_07085 ENOG4106WZ1 flagella biosynthesis regulator FX998_07090 ENOG4105F9N Major Facilitator Superfamily FX998_07095 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) FX998_07100 ENOG4105CWG Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity) FX998_07105 ENOG4105MH2 YfcL protein FX998_07110 ENOG4108BPE -transporting atpase FX998_07115 ENOG4105EJ9 Membrane FX998_07130 ENOG4105C76 Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity) FX998_07145 ENOG4105US4 fimbrial-like protein yfcP FX998_07150 ENOG4105UGQ Fimbrial FX998_07155 ENOG4105NEV Fimbrial FX998_07160 ENOG4108FZ9 Chaperone FX998_07165 ENOG4106PG1 outer membrane usher protein FX998_07175 ENOG4108BY2 phosphohistidine phosphatase FX998_07190 ENOG4105KZW UPF0381 protein FX998_07195 ENOG4105CKF membrane protein involved in aromatic hydrocarbon degradation FX998_07200 ENOG410836F Transposase FX998_07210 ENOG410903C (LipO)protein FX998_07215 ENOG4105S64 Formate nitrite transporter FX998_07225 ENOG4105U0F oligosaccharide H symporter, major facilitator superfamily (MFS) FX998_07230 ENOG4105D7K pfkb domain protein FX998_07235 ENOG4108HKT sucrose-6-phosphate hydrolase FX998_07240 ENOG4106NDP Transcriptional regulator FX998_07255 ENOG4105C0R drug resistance transporter emrb qaca subfamily FX998_07260 ENOG4105CW7 secretion protein, HlyD family FX998_07265 ENOG4108WQH regulatoR FX998_07270 ENOG4105BZU Histidine kinase FX998_07275 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F FX998_07280 ENOG4108N2Y auxin Efflux FX998_07285 ENOG4105CFN oxalyl-CoA decarboxylase FX998_07295 ENOG4108V08 YfdX protein FX998_07305 ENOG4105W9M Membrane FX998_07310 ENOG4105D1S lipid A biosynthesis FX998_07320 ENOG4105CHM Aminotransferase FX998_07325 ENOG4108HRK Histidine kinase FX998_07330 ENOG4105DY9 regulatoR FX998_07340 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) FX998_07345 ENOG4105CN9 Peptidase m42 family protein FX998_07350 ENOG4105DC7 peptidase M24 FX998_07355 ENOG410863U PTS System FX998_07360 ENOG4105R6B The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane (By similarity) FX998_07370 ENOG4105VCT ion-transport protein YfeO FX998_07375 ENOG4109076 Conserved Protein FX998_07385 ENOG4105D9N nucleoside FX998_07390 ENOG4108SER Transposase FX998_07395 ENOG4108KMM Diguanylate cyclase FX998_07410 ENOG4105HZG regulatoR FX998_07415 ENOG4105GXM Putative transcription regulator (DUF1323) FX998_07445 ENOG4105CN8 Transcriptional regulator FX998_07455 ENOG4105EAA nucleoside FX998_07460 ENOG4107U5R The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity) FX998_07465 ENOG4108NFH Sugar hydrolase FX998_07470 ENOG4108M0I Transcriptional regulator FX998_07475 ENOG4105DHU Bile acid FX998_07480 ENOG4105VRT cytoplasmic protein FX998_07485 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) FX998_07500 ENOG4105C6T cysteine synthase FX998_07505 ENOG4105KZ7 phosphocarrier protein hpr FX998_07510 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) FX998_07515 ENOG4105C5Y PTS System FX998_07525 ENOG4105M0Y FX998_07530 ENOG4105WEC Molybdate metabolism regulator FX998_07535 ENOG4105C6T cysteine synthase FX998_07540 ENOG4108IJ6 ABC transporter FX998_07545 ENOG4105ECW sulfate abc transporter FX998_07550 ENOG4108I5D sulfate abc transporter FX998_07555 ENOG4108J2H Sulfate ABC transporter periplasmic sulfate-binding protein FX998_07560 ENOG4105I7Z Short-chain dehydrogenase reductase Sdr FX998_07575 ENOG4105C5Y PTS System FX998_07580 ENOG4107S1E Beta-lactamase FX998_07585 ENOG4105EZR dyp-type peroxidase family protein FX998_07590 ENOG4105E7K (LipO)protein FX998_07595 ENOG4105QZU Inner membrane protein YfeZ FX998_07600 ENOG4108R6G acetyltransferase FX998_07605 ENOG4108KNB n-acetylmuramoyl-l-alanine amidase FX998_07615 ENOG4108K3Z AraC family transcriptional regulator FX998_07620 ENOG4108X49 Ethanolamine utilization protein EutK FX998_07625 ENOG4106D67 ethanolamine utilization protein FX998_07635 ENOG4105CPD ethanolamine ammonia-lyase FX998_07640 ENOG4105DYY Reactivating factor for ethanolamine ammonia lyase FX998_07645 ENOG4105ENY Ethanolamine utilization protein eutH FX998_07650 ENOG4105C0A alcohol dehydrogenase FX998_07655 ENOG4107RWI ethanolamine utilization protein eutJ FX998_07660 ENOG4108EKI Dehydrogenase FX998_07665 ENOG4105WVM ethanolamine utilization protein EutN carboxysome structural protein Ccml FX998_07670 ENOG4105KNY Microcompartments protein FX998_07675 ENOG4107WUY phosphate acetyltransferase FX998_07680 ENOG4108PFF ethanolamine utilization cobalamin adenosyltransferase FX998_07685 ENOG4105NDK ethanolamine utilization protein FX998_07690 ENOG4106S4J ethanolamine utilization protein EutP FX998_07695 ENOG4108VJN May be involved in the formation of a specific microcompartment in the cell in which the metabolism of potentially toxic by-products takes place FX998_07700 ENOG4105C6K Malic enzyme FX998_07705 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) FX998_07710 ENOG4105CV1 Transketolase (EC 2.2.1.1) FX998_07715 ENOG4108PVD exported protein FX998_07720 ENOG4107VIJ nudix hydrolase FX998_07725 ENOG4105BZ8 glutamate synthase FX998_07730 ENOG4105BZU Histidine kinase FX998_07735 ENOG4105BZS acriflavin resistance protein FX998_07745 ENOG4105KUZ arsenate reductase FX998_07760 ENOG4106KED esterase YpfH FX998_07765 ENOG4105E0I Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP) (By similarity) FX998_07770 ENOG4105CGZ zinc metallopeptidase FX998_07780 ENOG4107EG0 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) FX998_07790 ENOG4105RH4 Glycine cleavage system transcriptional repressor FX998_07795 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen FX998_07800 ENOG4108MFN small subunit of hydrogenase-3, iron-sulfur protein (part of formate hydrogenlyase (FHL) complex) FX998_07805 ENOG4108JPZ Monovalent cation H antiporter subunit D FX998_07810 ENOG4107TDF Formate hydrogenlyase subunit 4 FX998_07815 ENOG4105D65 subunit l FX998_07820 ENOG4107WQX hydrogenase 4 membrane subunit FX998_07825 ENOG4108JPZ Monovalent cation H antiporter subunit D FX998_07830 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) FX998_07840 ENOG4105C47 NADH ubiquinone oxidoreductase 20 kda subunit FX998_07845 ENOG4105I6X formate hydrogenlyase maturation FX998_07850 ENOG4108JUA Transcriptional regulator FX998_07855 ENOG4105TMB Formate nitrite transporter FX998_07860 ENOG4105C02 permease FX998_07865 ENOG4105ERG peptidase m48, ste24p FX998_07870 ENOG4105K89 arsenate reductase FX998_07880 ENOG4105C2W permease FX998_07895 ENOG4108V3E phosphoribosylglycinamide formyltransferase FX998_07900 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) FX998_07905 ENOG4105C9X ppx gppa phosphatase FX998_07910 ENOG4105BZU Histidine kinase FX998_07915 ENOG41062G3 Protein of unknown function (DUF2633) FX998_07920 ENOG4108ZMA Outer membrane lipoprotein FX998_07925 ENOG41066DY Membrane FX998_07935 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) FX998_07945 ENOG4105VPD cellular component movement FX998_07960 ENOG4105N21 Membrane FX998_07990 ENOG4108JQB penicillin-binding protein 1C FX998_07995 ENOG4105DN3 alpha-2-macroglobulin domain protein FX998_08000 ENOG4105KHC sulfurtransferase FX998_08005 ENOG4105YYA enhanced serine sensitivity protein SseB FX998_08015 ENOG4105WVQ Fe-S assembly protein IscX FX998_08020 ENOG4108ZIT Ferredoxin, 2FE-2S FX998_08040 ENOG4107XTC May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins FX998_08065 ENOG4107XM9 (LipO)protein FX998_08070 ENOG4108MN2 Stationary phase inducible protein CsiE FX998_08075 ENOG4105D8G Major Facilitator superfamily FX998_08080 ENOG4108W5M transcriptional regulator FX998_08085 ENOG4105FUY alpha subunit FX998_08110 ENOG4108SB3 DoxX Family FX998_08115 ENOG4108ZKT aldose 1-epimerase FX998_08120 ENOG4105CPQ Dehydrogenase FX998_08125 ENOG4105CNN ABC, transporter FX998_08130 ENOG4108F37 ATP-binding component of a transport system FX998_08135 ENOG4105FCA ABC transporter periplasmic-binding protein YphF FX998_08140 ENOG4107HQ7 repeat protein FX998_08145 ENOG4108NZE NAGC-like transcriptional regulator FX998_08155 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) FX998_08160 ENOG4108YZA Nitrogen regulatory protein pii FX998_08165 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family FX998_08170 ENOG4108SKK alpha helix protein FX998_08175 ENOG4107WP9 Histidine kinase FX998_08180 ENOG4107QIK phosphoribosylformylglycinamidine synthase FX998_08190 ENOG4108Z6B deaminase FX998_08195 ENOG4105HYY HAD superfamily (Subfamily IF) hydrolase, YfhB FX998_08200 ENOG4106G6Q Transcriptional regulator FX998_08205 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding FX998_08220 ENOG4105CSZ Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity) FX998_08240 ENOG4105C3F Signal peptidase i FX998_08250 ENOG4105WMJ Positive regulator of sigma E, RseC MucC FX998_08255 ENOG4105VQK sigma E regulatory protein, MucB RseB FX998_08260 ENOG41069PW sigma-e factor negative regulatory protein FX998_08265 ENOG4105EMN RNA polymerase sigma factor FX998_08275 ENOG4108IYU L-aspartate oxidase FX998_08280 ENOG4107S47 Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC) (By similarity) FX998_08285 ENOG4105C1J atp-dependent rna helicase FX998_08290 ENOG41090KR LysR family transcriptional Regulator FX998_08310 ENOG4105EIB trna rrna methyltransferase FX998_08315 ENOG4105K63 Thioredoxin FX998_08320 ENOG4106IUH DTW domain containing protein FX998_08325 ENOG4105CD5 CoA-binding domain protein FX998_08330 ENOG4105JIM Phosphatidylserine synthase FX998_08335 ENOG4105T42 (LipO)protein FX998_08340 ENOG4105CSH Transporter FX998_08365 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit FX998_08370 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase FX998_08375 ENOG4105C34 Pseudouridine synthase FX998_08380 ENOG4106SNF Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane FX998_08385 ENOG4108WPH sigma 54 modulation protein ribosomal protein S30EA FX998_08395 ENOG4105CQC Prephenate dehydratase FX998_08400 ENOG4105EHE chorismate mutase- prephenate dehydrogenase FX998_08405 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) FX998_08410 ENOG4105QP9 Protein of unknown function (DUF2799) FX998_08415 ENOG4108WS1 FX998_08420 ENOG4108KHX Diguanylate cyclase FX998_08425 ENOG41090EK ompa motb domain protein FX998_08450 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY FX998_08455 ENOG4106KVJ cytochrome C assembly protein FX998_08460 ENOG4108JU6 CBS domain protein FX998_08475 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) FX998_08480 ENOG4105YRI Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) FX998_08485 ENOG4105VDB UPF0125 protein FX998_08490 ENOG4108Z1B Cyclase dehydrase FX998_08505 ENOG4108MGN ATP-binding component of a transport system FX998_08545 ENOG4105D5U fad dependent oxidoreductase FX998_08550 ENOG4105C26 Dehydrogenase FX998_08555 ENOG4108JPW Aminotransferase FX998_08560 ENOG4105C85 amino acid FX998_08565 ENOG4108PVQ transcriptional regulator FX998_08570 ENOG4109066 lysm domain bon superfamily protein FX998_08575 ENOG4105VPI YqaE family transport protein FX998_08580 ENOG41080HT Transcriptional regulator, arsr family FX998_08585 ENOG4108V62 Rhodanese domain protein FX998_08590 ENOG4108X73 DNA- binding protein FX998_08595 ENOG4108RNS Exports L-alanine (By similarity) FX998_08600 ENOG4108WMJ Protein of unknown function (DUF2002) FX998_08605 ENOG4108ZQZ Bacterial protein of unknown function (DUF883) FX998_08610 ENOG4105WAZ (Glutaredoxin-like protein) NrdH FX998_08615 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) FX998_08620 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) FX998_08625 ENOG4107R25 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) FX998_08630 ENOG4108IJ7 Glycine betaine FX998_08635 ENOG4108HQS Glycine betaine FX998_08640 ENOG4105GIJ Glycine betaine FX998_08650 ENOG4108UMN azlc family FX998_08655 ENOG4105ZED uncharacterized protein ygaH FX998_08660 ENOG4105NTK Transcriptional repressor Mpra FX998_08665 ENOG4105CW7 secretion protein, HlyD family FX998_08670 ENOG4105C0R drug resistance transporter emrb qaca subfamily FX998_08685 ENOG4105W39 Membrane FX998_08690 ENOG4107VXZ Hydrolase FX998_08720 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) FX998_08725 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) FX998_08740 ENOG4107TH8 cina domain protein FX998_08745 ENOG4105CVE Lytic murein transglycosylase FX998_08750 ENOG410787A Pts system, glucitol sorbitol-specific FX998_08755 ENOG4105DZY Pts system, glucitol sorbitol-specific FX998_08760 ENOG4105VI0 Pts system, glucitol sorbitol-specific FX998_08765 ENOG4107QMF Sorbitol-6-phosphate dehydrogenase FX998_08770 ENOG4105J92 DNA-binding transcriptional activator GutM FX998_08775 ENOG410804X Transcriptional regulator FX998_08780 ENOG4105C2X Arabinose 5-phosphate isomerase FX998_08790 ENOG4108ESE uses NADH to detoxify nitric oxide (NO), protecting several 4Fe-4S NO-sensitive enzymes. Has at least 2 reductase partners, only one of which (NorW, flavorubredoxin reductase) has been identified. NO probably binds to the di-iron center FX998_08800 ENOG4105C8H hydrogenase maturation protein Hypf FX998_08805 ENOG4108RC0 Electron transport protein FX998_08810 ENOG4105DDV Transcriptional regulator (LacI family FX998_08815 ENOG4105C5Y PTS System FX998_08820 ENOG4105CS2 ec 3.2.1.21 FX998_08825 ENOG4108MG9 hydrogenase 3 maturation protease FX998_08830 ENOG4105I6X formate hydrogenlyase maturation FX998_08835 ENOG4105C47 NADH ubiquinone oxidoreductase 20 kda subunit FX998_08840 ENOG4108RG7 formate hydrogenlyase complex iron-sulfur subunit FX998_08845 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) FX998_08850 ENOG4107TDF Formate hydrogenlyase subunit 4 FX998_08855 ENOG4107R30 NADH dehydrogenase FX998_08860 ENOG4108MFN small subunit of hydrogenase-3, iron-sulfur protein (part of formate hydrogenlyase (FHL) complex) FX998_08865 ENOG4108VRC Formate hydrogenlyase regulatory protein hycA FX998_08875 ENOG410816D Probably plays a role in a hydrogenase nickel cofactor insertion step (By similarity) FX998_08880 ENOG4107RSS Hydrogenase accessory protein HypB FX998_08885 ENOG41083WG hydrogenase assembly chaperone FX998_08890 ENOG4105CQS hydrogenase expression formation protein HypD FX998_08895 ENOG4105C45 hydrogenase expression formation protein (HypE) FX998_08900 ENOG4108JUA Transcriptional regulator FX998_08905 ENOG4105VXR cytoplasmic protein FX998_08915 ENOG4105MEW serine threonine protein phosphatase FX998_08920 ENOG4105MVE transcriptional regulator FX998_08925 ENOG4105ZXK Dehydrogenase FX998_08930 ENOG4105G63 Type III effector Hrp-dependent FX998_08935 ENOG4105FB2 class II Aldolase FX998_08940 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) FX998_08945 ENOG4105C6Z Gluconate FX998_08950 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FX998_08955 ENOG4108K5P (LipO)protein FX998_08990 ENOG4105N0Z inner membrane protein ygbE FX998_09010 ENOG4108MXK alkaline phosphatase isozyme conversion FX998_09015 ENOG4105PWE CRISPR-associated protein cas2 FX998_09020 ENOG4105TZK CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. May be involved in the integration of spacer DNA into the CRISPR cassette (By similarity) FX998_09025 ENOG4108Y7V CRISPR-associated protein, Cse3 family FX998_09030 ENOG4108VWQ crispr-associated protein FX998_09035 ENOG41060M0 Crispr-associated protein, cse4 family FX998_09040 ENOG41061HK CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA) FX998_09045 ENOG4105CYR Crispr-associated protein, cse1 family FX998_09050 ENOG4105DTT CRISPR-associated helicase, cas3 FX998_09075 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase FX998_09080 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase FX998_09085 ENOG4105WQV ferredoxin-like protein FX998_09090 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator FX998_09095 ENOG4105YBM electron transfer flavoprotein subunit ygcQ FX998_09100 ENOG4106IKH Electron transfer flavoprotein FX998_09105 ENOG4105C54 Major Facilitator superfamily FX998_09110 ENOG4107R3A FAD linked oxidase domain protein FX998_09115 ENOG4105CHR reductase FX998_09120 ENOG4108ITV Inner membrane protein yqcE FX998_09125 ENOG4108CWB sugar kinase ygcE FX998_09130 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) FX998_09140 ENOG4105HA9 of methanol dehydrogenase type FX998_09155 ENOG4105DXN mazG family FX998_09160 ENOG4105MZG transcriptional modulator of maze toxin, mazf FX998_09165 ENOG4106A2Z transcriptional regulator antitoxin, MazE FX998_09170 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) FX998_09175 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) FX998_09180 ENOG4105BZU Histidine kinase FX998_09185 ENOG4105EQX glucarate dehydratase FX998_09190 ENOG4105EQX glucarate dehydratase FX998_09195 ENOG4105DJB Major Facilitator Superfamily FX998_09200 ENOG4105QDK Flavodoxin FX998_09205 ENOG4105DR9 pseudouridine synthase FX998_09210 ENOG4105WP7 tRNA pseudouridine synthase C FX998_09225 ENOG4105EWT decarboxylase family FX998_09230 ENOG4105C44 Serine transporter FX998_09235 ENOG4105EJQ L-serine dehydratase FX998_09245 ENOG4105C0A alcohol dehydrogenase FX998_09250 ENOG4107W7X Aldolase FX998_09255 ENOG4105EDR glucose galactose transporter FX998_09265 ENOG4105CMG Carbohydrate kinase FX998_09275 ENOG4107EDW L-fucose operon activator FX998_09285 ENOG4105M08 Membrane FX998_09290 ENOG4105ETT transcriptional Regulator, LysR family FX998_09295 ENOG4105M5B (LipO)protein FX998_09300 ENOG4105C9B Cysteine desulfurase FX998_09305 ENOG4105P9C Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity) FX998_09310 ENOG4105CUZ uba thif-type nad fad binding protein FX998_09315 ENOG4105CA3 membrane-bound lytic murein transglycosylase FX998_09335 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase FX998_09340 ENOG4107QZM n-acetylglutamate synthase FX998_09345 ENOG4107QYX exodeoxyribonuclease v alpha FX998_09350 ENOG4107QKA exodeoxyribonuclease V beta FX998_09355 ENOG4107QXK peptidase FX998_09360 ENOG4105DSY exodeoxyribonuclease V, gamma FX998_09365 ENOG4105RVB Prepilin peptidase dependent protein c FX998_09370 ENOG4105SEN Protein of unknown function (DUF2509) FX998_09375 ENOG4105JCS prepilin peptidase dependent protein FX998_09380 ENOG4105IPU prepilin peptidase dependent protein A FX998_09395 ENOG4108HRM phosphoenolpyruvate--protein phosphotransferase FX998_09415 ENOG4105EE5 Membrane protein terC FX998_09420 ENOG4105SUV lipoprotein YgdR FX998_09425 ENOG4105CPC Aldo Keto reductase FX998_09445 ENOG41060NJ transcriptional regulator FX998_09450 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) FX998_09455 ENOG4105RQF LysR family Transcriptional regulator FX998_09465 ENOG4107QNK )-transporter FX998_09470 ENOG4105CHR reductase FX998_09480 ENOG4105CHU acetyl-coa acetyltransferase FX998_09485 ENOG4108MHD transport protein FX998_09490 ENOG4105ISV protein with bipartite regulator domain FX998_09495 ENOG4108TC1 Transcriptional regulator FX998_09500 ENOG4105FV3 FX998_09525 ENOG4108YAB Invasion protein FX998_09555 ENOG4108RBT type iii secretion FX998_09560 ENOG4106BTR FX998_09565 ENOG4105Y7Q type iii secretion FX998_09570 ENOG4108RC9 Type III secretion system protein FX998_09575 ENOG4108RC9 Type III secretion system protein FX998_09590 ENOG4108M6W surface presentation of antigens protein SpaS FX998_09595 ENOG4108M6W surface presentation of antigens protein SpaS FX998_09600 ENOG4108TN6 type iii secretion FX998_09610 ENOG41075IY surface presentation of antigens protein SpaP FX998_09625 ENOG4108SER Transposase FX998_09660 ENOG4108IYT Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) FX998_09670 ENOG4108K5P (LipO)protein FX998_09675 ENOG4105C7W Xanthine dehydrogenase FX998_09680 ENOG4108HR6 Dehydrogenase FX998_09685 ENOG4108UTP (2Fe-2S)-binding domain protein FX998_09690 ENOG4108JUB Transcriptional regulator FX998_09695 ENOG4105IW6 Carbamoyltransferase FX998_09700 ENOG4107RCH Diaminopropionate ammonia-lyase FX998_09705 ENOG4107S4Y M20 DapE family protein YgeY FX998_09715 ENOG4105C5B carbamate kinase FX998_09720 ENOG4107P0T Selenium-dependent molybdenum hydroxylase system protein, YqeB family FX998_09725 ENOG4105MJ6 selenium-dependent hydroxylase accessory protein YqeC FX998_09730 ENOG4105MFX 4-diphosphocytidyl-2c-methyl-d-erythritol synthase FX998_09735 ENOG4105BZ8 glutamate synthase FX998_09740 ENOG4107UUR Chlorohydrolase aminohydrolase FX998_09745 ENOG410873Y FAD binding domain in molybdopterin dehydrogenase FX998_09750 ENOG4105C7W Xanthine dehydrogenase FX998_09755 ENOG4105C2W permease FX998_09760 ENOG4107QUY Guanine deaminase FX998_09765 ENOG4105C7N Xanthine uracil vitamin C permease FX998_09770 ENOG4108R8B oxidoreductase Fe-S subunit FX998_09775 ENOG4105BZ8 glutamate synthase FX998_09780 ENOG4105C2W permease FX998_09800 ENOG4105CRK lysyL-tRNA synthetase FX998_09810 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) FX998_09815 ENOG4105T95 Thiol disulfide interChange protein FX998_09820 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) FX998_09825 ENOG41071R3 Low-potential electron donor to a number of redox enzymes (By similarity) FX998_09830 ENOG4108YDB Toxic component of a toxin-antitoxin (TA) module. Overexpression leads to growth arrest after 5 hours, with initial elongation of cells, followed by swelling. The toxic effects are abrogated by coexpression with antitoxin CptB. Interacts with cytoskeletal proteins FtsZ and MreB FX998_09835 ENOG4105Y75 tpr repeat protein FX998_09845 ENOG4108UT2 hemolysin iii FX998_09850 ENOG4105N5Z UPF0267 protein FX998_09855 ENOG4105CS2 ec 3.2.1.21 FX998_09860 ENOG4105CYX Short-chain dehydrogenase reductase Sdr FX998_09885 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family FX998_09890 ENOG4105D0A hydroxylase FX998_09895 ENOG4107RAQ aminopeptidase FX998_09915 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase FX998_09925 ENOG4108JQ1 Dehydrogenase FX998_09945 ENOG4105D5P Methylmalonyl-coA mutase FX998_09950 ENOG4105DJT lAO AO transport system ATPase FX998_09955 ENOG4108M7F enoyl-CoA hydratase isomerase FX998_09960 ENOG4105CYC Transferase FX998_09965 ENOG4105DEQ transcriptional regulator FX998_09970 ENOG4105MPN Membrane FX998_09975 ENOG4108ZUB Lysine exporter protein (Lyse ygga) FX998_09980 ENOG4105D64 Mechanosensitive ion channel FX998_09985 ENOG4105D2N Aldolase FX998_10000 ENOG4107Z1W Fructose transport system kinase FX998_10005 ENOG4108R4K DNA-binding, transcriptional regulator FX998_10010 ENOG4108Q8A Fructose-1,6-bisphosphatase FX998_10015 ENOG4105DXH Alcohol dehydrogenase zinc-binding domain protein FX998_10020 ENOG4105CTS PTS system mannitol-specific FX998_10025 ENOG4108X7Y Mannitol-specific cryptic phosphotransferase enzyme iia FX998_10030 ENOG4105CV1 Transketolase (EC 2.2.1.1) FX998_10035 ENOG4108K0D peptidase, M48 FX998_10045 ENOG4105DP5 Catalyzes the biosynthesis of agmatine from arginine (By similarity) FX998_10060 ENOG4107QNK )-transporter FX998_10070 ENOG4105RWS endonuclease I FX998_10075 ENOG4105QF0 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) FX998_10080 ENOG4105D7Z glutathione synthase FX998_10095 ENOG4105CZX twitching motility protein FX998_10100 ENOG4105DFA alanine racemase domain protein FX998_10105 ENOG4108VIA integral membrane protein FX998_10115 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) FX998_10120 ENOG4105CSA Coproporphyrinogen iii oxidase FX998_10125 ENOG4106MH3 alpha helix chain FX998_10130 ENOG4105HDK L-asparaginase FX998_10135 ENOG4105K33 Periplasmic Protein FX998_10140 ENOG41090ED Protein with unknown function (DUF469) FX998_10150 ENOG4105CEN a g-specific adenine glycosylase FX998_10165 ENOG4105EAA nucleoside FX998_10170 ENOG4105CXN decarboxylase FX998_10175 ENOG4108UQV Membrane FX998_10200 ENOG4108I6E Sulfatase FX998_10205 ENOG4105T40 surface antigen msp4 family protein FX998_10225 ENOG4107QRT dEAD DEAH box helicase FX998_10245 ENOG4105F5W AtP-binding protein FX998_10250 ENOG4105D70 Integrase catalytic subunit FX998_10260 ENOG4105GTN ParB Domain Protein Nuclease FX998_10265 ENOG4105BZV Phosphoadenosine phosphosulfate reductase FX998_10320 ENOG4108VPX Involved in 1,2-propanediol (1,2-PD) degradation by catalyzing the conversion of propanoyl-CoA to propanoyl-phosphate (By similarity) FX998_10325 ENOG4107RWI ethanolamine utilization protein eutJ FX998_10335 ENOG4105WVM ethanolamine utilization protein EutN carboxysome structural protein Ccml FX998_10350 ENOG4105KNY Microcompartments protein FX998_10355 ENOG4105EHR propanediol utilization protein pduB FX998_10360 ENOG4108EKI Dehydrogenase FX998_10370 ENOG4107R7Y intracellular protease Pfpi family FX998_10375 ENOG4105C6N Formate acetyltransferase FX998_10380 ENOG4105F1A Pyruvate formate-lyase FX998_10400 ENOG4105EKQ RNA-directed DNA polymerase FX998_10410 ENOG4105C2F Histidine kinase FX998_10415 ENOG4106R3P AraC family transcriptional regulator FX998_10420 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP FX998_10425 ENOG4105KNY Microcompartments protein FX998_10470 ENOG4105DD7 kinase (PfkB family FX998_10475 ENOG4105D9N nucleoside FX998_10480 ENOG4105D53 Catalyzes the hydrolysis of pseudouridine 5'-phosphate (PsiMP) to ribose 5-phosphate and uracil (By similarity) FX998_10485 ENOG4105DD7 kinase (PfkB family FX998_10490 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) FX998_10525 ENOG4105TS0 gtp-binding protein FX998_10530 ENOG4108KZE transcriptional regulator FX998_10545 ENOG4106H6R UPF0380 protein FX998_10550 ENOG4106549 Antirestriction protein FX998_10555 ENOG4108YGG dna repair protein FX998_10560 ENOG4106WJE Protein of unknown function (DUF987) FX998_10565 ENOG4105MAW Antitoxin component of a toxin-antitoxin (TA) module. Labile antitoxin that counteracts the effect of the CbtA (YeeV) toxin. It does not bind to the cognate toxin but instead binds to MreB and FtsZ (the toxin targets), enhancing their polymerization by forming higher-order bundles FX998_10590 ENOG4105U1E general secretion pathway protein M FX998_10610 ENOG4105X5Z General secretion pathway protein I FX998_10620 ENOG4108VAU general secretion pathway protein G FX998_10625 ENOG4105D7Q type ii secretion system FX998_10640 ENOG4108XKW General secretion pathway protein C FX998_10645 ENOG410765S (LipO)protein FX998_10650 ENOG4105EHH Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue (By similarity) FX998_10655 ENOG4105F88 accessory colonization factor AcfD FX998_10660 ENOG4105DAA L-lactate FX998_10665 ENOG4107QP3 malate synthase g FX998_10670 ENOG4108ZJF Glcg protein FX998_10675 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) FX998_10680 ENOG4105EU8 FAD linked oxidase domain protein FX998_10685 ENOG4105CQB FAD linked oxidase domain protein FX998_10690 ENOG4108KWP DNA-binding transcriptional regulator GlcC FX998_10700 ENOG4107RCI amp-dependent synthetase and ligase FX998_10710 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) FX998_10715 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) FX998_10725 ENOG4108M8S permease YjgP YjgQ family protein FX998_10730 ENOG4108UUE Transcriptional regulator FX998_10740 ENOG4108S55 polysaccharide biosynthesis protein FX998_10745 ENOG4106FPV ATP-binding protein YghR FX998_10750 ENOG4108NDC ATP-binding protein yghS FX998_10755 ENOG4108GH0 ATP-binding protein yghT FX998_10760 ENOG4105CJ3 phosphate transporter FX998_10765 ENOG4106032 Glutathionylspermidine synthase FX998_10770 ENOG4105CYM Glutathione S-transferase FX998_10775 ENOG41082MF Hydrogenase assembly chaperone hypC hupF FX998_10780 ENOG4105WMM Probably plays a role in a hydrogenase nickel cofactor insertion step (By similarity) FX998_10785 ENOG4108WGS hydrogenase 2-specific chaperone FX998_10790 ENOG4108USZ hydrogenase FX998_10795 ENOG4105DPX Hydrogenase, large subunit FX998_10800 ENOG4105CJ5 hydrogenase 2 b cytochrome subunit FX998_10805 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein FX998_10810 ENOG4105E3S small subunit FX998_10815 ENOG410900S Protein of unknown function (DUF2623) FX998_10825 ENOG4105CPC Aldo Keto reductase FX998_10835 ENOG4105CYX Short-chain dehydrogenase reductase Sdr FX998_10840 ENOG4108ZZF transport protein (ExbD) FX998_10845 ENOG4105CWK Biopolymer transport protein, ExbB FX998_10850 ENOG4105C28 cystathionine FX998_10855 ENOG4108K81 inner membrane protein YghB FX998_10860 ENOG4105CF7 AraC family transcriptional regulator FX998_10865 ENOG4108I6A alcohol dehydrogenase FX998_10870 ENOG4105CV8 reductase FX998_10875 ENOG4105ZKC Conserved Protein FX998_10885 ENOG4105CCT upf0313 protein FX998_10890 ENOG4107TZ2 Cell division protein that is required for growth during stress conditions. May be involved in protecting or stabilizing the divisomal assembly under conditions of stress (By similarity) FX998_10895 ENOG4107S7E 1-acyl-sn-glycerol-3-phosphate acyltransferase FX998_10900 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) FX998_10905 ENOG4108J59 Extracellular solute-binding protein, family 5 FX998_10910 ENOG4105WJ3 XRE family Transcriptional regulator FX998_10915 ENOG4105RT5 Toxic component of a toxin-antitoxin (TA) module. An mRNA interferase which has been reported to be translation- independent (PubMed 19690171, PubMed 19943910) and translation- dependent (PubMed 20041169). Cleavage has been reported to occur on either side of G in the sequence GCU (PubMed 19690171) but also after C in GC(A U) sequences (PubMed 19943910). There are only 14 genes in E.coli W3110 (and probably also MG1655) that do not have a GCU sequence and thus are resistant to the mRNA interferase activity. Overexpression causes cessation of cell growth and inhibits cell proliferation via inhibition of translation as well as increasing persister cell formation FX998_10920 ENOG4105F4I Transcriptional regulator FX998_10925 ENOG4105H4F exported protein FX998_10930 ENOG4105XJC Two component transcriptional regulator (Winged helix family FX998_10935 ENOG4105DHQ Histidine kinase FX998_10940 ENOG4107DEU Inner membrane protein YgiZ FX998_10945 ENOG4105NF4 modulator of drug activity FX998_10950 ENOG4105VRH Antibiotic biosynthesis monooxygenase FX998_10955 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) FX998_10960 ENOG4105IPS esterase FX998_10965 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) FX998_10970 ENOG4108SX3 cytoplasmic protein FX998_10975 ENOG41087AY ADP-Ribose pyrophosphatase FX998_10980 ENOG4105DFG type I secretion outer membrane protein FX998_10990 ENOG4106032 Glutathionylspermidine synthase FX998_10995 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b FX998_11010 ENOG4105W0Z cytoplasmic protein FX998_11015 ENOG4105H8W Fimbrial protein FX998_11035 ENOG4108TTM chaperone FX998_11040 ENOG4108MY7 Fimbrial FX998_11050 ENOG4105PV3 Inner membrane protein yqiJ FX998_11060 ENOG4107S78 Band 7 protein FX998_11085 ENOG4105I7R Adenylate cyclase FX998_11090 ENOG4106MWK domain protein FX998_11100 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) FX998_11105 ENOG4107ZVW dihydroneopterin aldolase FX998_11115 ENOG4105EJC lysr family transcriptional regulator FX998_11120 ENOG4106DSS Tartrate dehydratase subunit alpha FX998_11125 ENOG4107GFK fumarate FX998_11130 ENOG4107QPK )-transporter FX998_11140 ENOG4105VCC 30S ribosomal protein S21 FX998_11145 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) FX998_11150 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FX998_11165 ENOG4105Q26 Siderophore-interacting protein FX998_11170 ENOG4105NTW Transcriptional regulator FX998_11175 ENOG4107RHT methyl-accepting chemotaxis sensory transducer with Pas Pac sensor FX998_11185 ENOG4108Y51 tRNA-binding protein FX998_11190 ENOG4105CQ4 Transcriptional regulator FX998_11195 ENOG4105CNT hydrolase family 2 FX998_11200 ENOG4105FK9 beta-D-galactosidase beta subunit FX998_11205 ENOG4105E5D amino acid FX998_11210 ENOG4107W6W Conserved Protein FX998_11215 ENOG4107WCA isomerase FX998_11220 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase FX998_11225 ENOG4108Z3N Transcriptional regulator FX998_11230 ENOG4105R48 this blockage is overcome by subsequent expression of antitoxin HigA. Overexpression causes cleavage of a number of mRNAs in a translation-dependent fashion, suggesting this is an mRNA interferase FX998_11235 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) FX998_11240 ENOG4108VKG metal-dependent hydrolase FX998_11245 ENOG4108UB4 uncharacterized protein ygjQ FX998_11250 ENOG4105EE0 oxidoreductase FX998_11255 ENOG4105DU1 integral membrane protein, terc FX998_11260 ENOG4107QV7 Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system) (By similarity) FX998_11265 ENOG4105P66 Membrane FX998_11270 ENOG4105CTX dehydratase FX998_11280 ENOG4105DPW Major facilitator superfamily MFS_1 FX998_11285 ENOG4107YCY Transcriptional regulator FX998_11290 ENOG4106W5V Membrane FX998_11295 ENOG4105IYR Modulates the activity of the EnvZ OmpR two-component regulatory system, probably by directly modulating EnvZ enzymatic activity and increasing stability of phosphorylated OmpR (By similarity) FX998_11300 ENOG4105WAY exported protein FX998_11305 ENOG4105NE1 Conserved Protein FX998_11310 ENOG41090KG Inner membrane protein YqjE FX998_11315 ENOG4105YJD FX998_11320 ENOG4108VBZ doxx family FX998_11325 ENOG4105CHF Glutathione S-transferase FX998_11330 ENOG4105KAF membrAne FX998_11340 ENOG4105KAF membrAne FX998_11345 ENOG4105CWB LysR family transcriptional Regulator FX998_11350 ENOG4108CNN domain protein FX998_11355 ENOG4106D80 Uncharacterized protein YhaL FX998_11365 ENOG4105C44 Serine transporter FX998_11370 ENOG4105EJQ L-serine dehydratase FX998_11375 ENOG4105KME endoribonuclease L-psp FX998_11380 ENOG4105C6N Formate acetyltransferase FX998_11385 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) FX998_11395 ENOG4105C7B Threonine dehydratase FX998_11400 ENOG410811B TRANSCRIPTIONal FX998_11425 ENOG4105BZW Glycerate kinase FX998_11430 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase FX998_11440 ENOG4105DJB Major Facilitator Superfamily FX998_11445 ENOG4105CTX dehydratase FX998_11450 ENOG4105ZEG Suppressor protein FX998_11455 ENOG4108R8Z these effects are overcome by concomitant expression of antitoxin SohA (PrlF). Massive overexpression is toxic. Unlike most other characterized TA systems degrades rRNA, and co-folding of the proteins is necessary in vitro for inhibition of the RNase activity. It is not known if it has any sequence-specificity. Acts as a transcription factor. The YhaV PrlF complex binds the prlF-yhaV operon, probably negatively regulating its expression FX998_11460 ENOG4105E98 transcriptional regulator DeoR family FX998_11470 ENOG4108RG5 PTS system N-acetylgalactosamine-specific transporter subunit IIB FX998_11480 ENOG4105F3R pts system mannose fructose sorbose family iid FX998_11485 ENOG4108YTN IIa component FX998_11490 ENOG4105CE4 GlcNAc 6-P deacetylase FX998_11495 ENOG4105E70 isomerase FX998_11505 ENOG4108UZY PTS System FX998_11515 ENOG4105ETZ PTS System FX998_11520 ENOG4105F3R pts system mannose fructose sorbose family iid FX998_11525 ENOG4106HBN Galactosamine-6-phosphate isomerase FX998_11530 ENOG4105Q10 Fimbrial-like protein FX998_11535 ENOG4108VCD Chaperone FX998_11540 ENOG4105CW0 outer membrane usher protein FX998_11545 ENOG4105I74 Fimbrial protein FX998_11550 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) FX998_11555 ENOG4105E1C Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1A (PBP1a) (By similarity) FX998_11565 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) FX998_11570 ENOG4105W4M Transport-associated protein FX998_11575 ENOG4107S21 permease FX998_11580 ENOG4105K4T epimerase FX998_11585 ENOG4107R7Y intracellular protease Pfpi family FX998_11600 ENOG4108YYD acetyltransferase FX998_11605 ENOG4105XPQ lipid carrier protein FX998_11610 ENOG4105CFP Peptidase U32 FX998_11615 ENOG4106RZ4 Peptidase U32 FX998_11620 ENOG4105DEN Luciferase family FX998_11625 ENOG4105CIC tryptophan-specific transport protein FX998_11630 ENOG4105C1J atp-dependent rna helicase FX998_11640 ENOG4105RT1 May be involved in cell division (By similarity) FX998_11655 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) FX998_11670 ENOG4105CHV Transcription elongation factor NusA FX998_11690 ENOG4105DIJ Phosphoethanolamine transferase FX998_11710 ENOG4105EEI dihydropteroate synthase FX998_11715 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) FX998_11720 ENOG4105F7M Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit (By similarity) FX998_11725 ENOG4105HBR Rna-binding protein FX998_11730 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) FX998_11735 ENOG4106HRJ d-alanyl-d-alanine carboxypeptidase FX998_11740 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control FX998_11745 ENOG4105QYV Membrane FX998_11760 ENOG4105EAH synthase FX998_11765 ENOG4105HVQ Regulatory factor of maltose metabolism FX998_11775 ENOG4105VFK BolA family FX998_11780 ENOG4105UE2 Part of the ABC transporter complex MlaFEDB that actively prevents phospholipid accumulation at the cell surface. Probably maintains lipid asymmetry in the outer membrane by retrograde trafficking of phospholipids from the outer membrane to the inner membrane FX998_11785 ENOG4105E3I toluene tolerance FX998_11790 ENOG4107PE3 Mammalian cell entry related domain protein FX998_11795 ENOG4105CY3 ABC transporter, permease FX998_11800 ENOG4105DHJ ABC, transporter FX998_11805 ENOG4105FEU K -dependent Na -Ca exchanger FX998_11810 ENOG4105C2X Arabinose 5-phosphate isomerase FX998_11815 ENOG4108Z4R 3-deoxy-d-manno-octulosonate 8-phosphate phosphatase FX998_11820 ENOG4108P1K Required for the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane (By similarity) FX998_11825 ENOG4105WI0 lipopolysaccharide transport periplasmic protein lptA FX998_11830 ENOG4108IUZ ABC transporter FX998_11835 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FX998_11840 ENOG41080QH sigma 54 modulation protein ribosomal protein S30EA FX998_11845 ENOG4107RM2 PTS IIA-like nitrogen-regulatory protein PtsN FX998_11855 ENOG41080Z8 PHOSPHOCARRIER protein FX998_11860 ENOG4108NIH transferase activity, transferring phosphorus-containing groups FX998_11870 ENOG4108556 Isoprenoid biosynthesis protein with amidotransferase-like domain FX998_11875 ENOG4105BZU Histidine kinase FX998_11880 ENOG4105N5T Radical SAM Protein FX998_11885 ENOG4105CBC glutamate synthase FX998_11890 ENOG4105BZ8 glutamate synthase FX998_11895 ENOG4106AJS Involved in induction of the so-called NTR enzymes in response to nitrogen deprivation, as well as in glutamate biosynthesis. May mediate the glutamate-dependent repression of the GLT operon FX998_11900 ENOG4108S1B Periplasmic chaperone protein FX998_11905 ENOG4105E6S usher protein( FX998_11915 ENOG4105UMR response to DNA damage stimulus FX998_11945 ENOG4105DFS Conserved Protein FX998_11950 ENOG4108R66 Conserved Protein FX998_11980 ENOG4105CEE C4-dicarboxylate transporter FX998_11985 ENOG4105KB2 stringent starvation protein b FX998_11990 ENOG4107MKT Stringent starvation protein a FX998_11995 ENOG4108UJD 30S ribosomal protein S9 FX998_12005 ENOG4105D6Z AFG1 family ATPase FX998_12010 ENOG4108W2Q Cytochrome d ubiquinol oxidase subunit III FX998_12015 ENOG4105C0H protease FX998_12020 ENOG4105C0H protease FX998_12035 ENOG4105RID UPF0379 protein yhcN FX998_12040 ENOG4105UNR (Barnase) inhibitor FX998_12060 ENOG4105CR8 Transcriptional regulator FX998_12065 ENOG4105D1U peptidase U62 modulator of DNA gyrase FX998_12070 ENOG4105QD6 exported protein FX998_12075 ENOG4105C03 ribonuclease FX998_12080 ENOG4108Z03 MAF-like protein FX998_12085 ENOG4105VQ7 Rod shape-determining protein MreD FX998_12090 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) FX998_12095 ENOG4105DFF Rod shape-determining protein mreb FX998_12100 ENOG41062P1 Diguanylate cyclase phosphodiesterase FX998_12105 ENOG4105D3Z quinone oxidoreductase, yhdh yhfp family FX998_12110 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein FX998_12115 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase FX998_12120 ENOG4105RG0 Membrane FX998_12125 ENOG4108IA2 Sodium pantothenate symporter FX998_12135 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) FX998_12140 ENOG4105VY0 Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters (By similarity) FX998_12145 ENOG4105CEC DNA methylase N-4 N-6 FX998_12165 ENOG4105BZS acriflavin resistance protein FX998_12170 ENOG4105XCM membrane LIPOPROTEIN FX998_12180 ENOG4105EZ7 amino acid ABC transporter FX998_12185 ENOG4105DRP amino acid AbC transporter FX998_12190 ENOG4105CDA abc transporter atp-binding protein FX998_12235 ENOG4108Z0R Transferase FX998_12240 ENOG4105SG3 Protein of unknown function (DUF1488) FX998_12250 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) FX998_12255 ENOG4108WI1 Dna topoisomerase FX998_12265 ENOG4105C79 DNA protecting protein DprA FX998_12285 ENOG4105C1A potassium transporter peripheral membrane FX998_12295 ENOG4105VCN Rescues the ribosomes stalled at the 3' end of non-stop mRNAs. May induce hydrolysis of the ribosome-bound peptidyl-tRNA. This activity is crucial when the stalled ribosome can not be rescued by the SsrA(tmRNA)-SmpB quality control system FX998_12300 ENOG4105W1Y Transcriptional regulator FX998_12305 ENOG4105VTS DnaJ-like, subfamily C FX998_12315 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) FX998_12320 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) FX998_12330 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits FX998_12335 ENOG41067V7 50S ribosomal protein L36 FX998_12340 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) FX998_12355 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) FX998_12360 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) FX998_12370 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) FX998_12385 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) FX998_12395 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal FX998_12405 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) FX998_12410 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) FX998_12415 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) FX998_12420 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) FX998_12430 ENOG41080KG One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) FX998_12435 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) FX998_12450 ENOG4107ACA Calcium-binding protein required for initiation of chromosome replication FX998_12455 ENOG410899B May play a regulatory role under conditions of derepressed gsp gene expression FX998_12460 ENOG4107KSE General secretion pathway protein C FX998_12465 ENOG4105GVR general secretion pathway protein D FX998_12470 ENOG4107QHF type ii secretion system protein e FX998_12475 ENOG4105D7Q type ii secretion system FX998_12480 ENOG4108VAU general secretion pathway protein G FX998_12485 ENOG41069X0 general secretion pathway protein h FX998_12500 ENOG4105R04 type II secretion system protein K FX998_12505 ENOG41063JA Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins (By similarity) FX998_12515 ENOG4105EHH Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue (By similarity) FX998_12520 ENOG4108UQY Iron-storage protein FX998_12525 ENOG4105W53 bacterioferritin-associated ferredoxin FX998_12530 ENOG4108NNZ chitinase FX998_12570 ENOG4105WWK YheO domain protein FX998_12575 ENOG4108V1T peptidylprolyl cis-trans isomerase FX998_12585 ENOG4108YZY peptidylprolyl cis-trans isomerase FX998_12590 ENOG4105VKU nucleicacid-binding protein FX998_12605 ENOG4105C5H ABC transporter FX998_12610 ENOG4105DNZ Alpha Beta Hydrolase FX998_12620 ENOG4105CJE phosphoribulokinase (EC 2.7.1.19) FX998_12625 ENOG4108UKZ OsmC family FX998_12630 ENOG4107RYR Transcriptional regulator, Crp Fnr family FX998_12635 ENOG410613R integral membrane protein, YccS YhfK family FX998_12640 ENOG4105C8Y Acetylornithine aminotransferase FX998_12645 ENOG4105DDQ anthranilate synthase FX998_12650 ENOG4105MZU cell filamentation protein FX998_12655 ENOG4106195 uncharacterized protein yhfG FX998_12660 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) FX998_12670 ENOG4107QZF nitrite reductase NADPH large subunit FX998_12675 ENOG4105WZK nitrite reductase NADPH small subunit FX998_12680 ENOG4107V9H nitrite transporter FX998_12690 ENOG4105VYH FX998_12695 ENOG4107QHQ amino acid FX998_12700 ENOG4107R1S catalyzes the conversion of fructoselysine 6-phosphate to glucose 6-phosphate and lysine FX998_12705 ENOG4107Y0V Not clear, may be involved in an isomerization step FX998_12710 ENOG4108KPW sugar kinase FX998_12715 ENOG4105FDP GntR family transcriptional regulator FX998_12720 ENOG4106PKC pyridoxal phosphate binding FX998_12725 ENOG4106M0N transport system permease protein FX998_12730 ENOG4105MUZ Protein of unknown function DUF2620 FX998_12735 ENOG41080QX K07048 phosphotriesterase-related protein FX998_12740 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) FX998_12745 ENOG4108626 Racemase FX998_12750 ENOG4105RMW regulation of transcription, DNA-dependent FX998_12755 ENOG4108M21 FX998_12765 ENOG4105C31 Tryptophanyl-tRNA synthetase FX998_12770 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) FX998_12775 ENOG4105DJV ribulose-phosphate 3-epimerase FX998_12780 ENOG4105DFE Dna adenine methylase FX998_12785 ENOG4105EGB membrane protein DamX FX998_12800 ENOG4105E4G Type IV pilus FX998_12805 ENOG4105ITY Required for the use of extracellular DNA as a nutrient FX998_12810 ENOG4105XPX DNA utilization protein HofO FX998_12815 ENOG41065NF Fimbrial assembly family protein FX998_12820 ENOG4108U1Q Pilus assembly protein FX998_12825 ENOG4108JQC penicillin-binding protein 1A FX998_12830 ENOG4107RK2 ADP-ribose diphosphatase NudE FX998_12835 ENOG4105DQY intracellular growth attenuator FX998_12840 ENOG4107Y3D HAD-superfamily hydrolase subfamily IA variant 3 FX998_12845 ENOG4105VEJ Heat shock protein FX998_12855 ENOG4108MAJ Membrane FX998_12865 ENOG4105E0F Histidine kinase FX998_12870 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FX998_12875 ENOG4108RRZ Transcription elongation factor GreB FX998_12880 ENOG4105BZM domain protein FX998_12885 ENOG4105XFK Ferrous iron transport protein A FX998_12890 ENOG4105CE1 Ferrous iron transport protein b FX998_12900 ENOG4105DNE Transposase FX998_12910 ENOG4105MJ2 Competence protein FX998_12920 ENOG4105C6Z Gluconate FX998_12925 ENOG4107RTM 4-alpha-glucanotransferase (EC 2.4.1.25) FX998_12930 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) FX998_12945 ENOG4105E0Y RtcB Protein FX998_12950 ENOG4105CYB regulatoR FX998_12955 ENOG4105E98 transcriptional regulator DeoR family FX998_12970 ENOG4105C6V Glycerol-3-phosphate dehydrogenase FX998_12980 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) FX998_13005 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) FX998_13010 ENOG41076UM multiple antibiotic resistance (MarC)-related protein FX998_13015 ENOG4105C6Z Gluconate FX998_13020 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family FX998_13025 ENOG4105DIQ Transcriptional regulator FX998_13030 ENOG4105C2I pirin domain protein FX998_13035 ENOG4105D9R oxidoreductase FX998_13040 ENOG4105WCN acetyltransferase FX998_13045 ENOG4105GMB type VI secretion system effector, hcp1 family FX998_13060 ENOG4106FA4 FX998_13065 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) FX998_13075 ENOG4107T6V glycerophosphoryl diester phosphodiesterase FX998_13080 ENOG4108IJ9 (ABC) transporter FX998_13085 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component FX998_13090 ENOG4105E4X binding-protein-dependent transport systems inner membrane Component FX998_13095 ENOG4105BZ7 extracellular solute-binding protein family 1 FX998_13100 ENOG4108IV0 ABC, transporter FX998_13105 ENOG4105C0Z ABC transporter FX998_13110 ENOG4105CF8 branched-chain amino acid ABC transporter, permease FX998_13115 ENOG4105C32 Amino acid ABC transporter (Permease) FX998_13120 ENOG4105CP9 extracellular ligand-binding receptor FX998_13125 ENOG4105U59 -acetyltransferase FX998_13130 ENOG4105CP9 extracellular ligand-binding receptor FX998_13135 ENOG4105DEK Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FX998_13140 ENOG4105CRP Part of the ABC transporter FtsEX involved in FX998_13145 ENOG4105CAK Cell division ATP-binding protein ftsE FX998_13150 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) FX998_13155 ENOG4106H78 methyltransferase FX998_13160 ENOG4105MG3 Membrane FX998_13170 ENOG4107FS9 Membrane FX998_13175 ENOG4105C59 p-type ATPase FX998_13185 ENOG4105EX9 Membrane FX998_13190 ENOG4108W1V Lipoprotein FX998_13195 ENOG4105F9N Major Facilitator Superfamily FX998_13200 ENOG4105DSF transport protein FX998_13205 ENOG4107YAK holo-(acyl carrier protein) synthase 2 FX998_13210 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein FX998_13215 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component FX998_13220 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FX998_13225 ENOG4106665 Part of the ABC transporter complex NikABCDE involved in nickel import. Responsible for energy coupling to the transport system (By similarity) FX998_13230 ENOG4105EFJ Part of the ABC transporter complex NikABCDE involved in nickel import. Responsible for energy coupling to the transport system (By similarity) FX998_13250 ENOG4105NUP lyase containing HEAT-repeat FX998_13255 ENOG410600T transposase FX998_13260 ENOG4105CMI transporter FX998_13265 ENOG4105CJ1 ABC, transporter FX998_13270 ENOG4105D0S secretion protein (HlyD FX998_13285 ENOG4107UNS conserved inner membrane protein FX998_13290 ENOG4105CBX hi0933 family FX998_13295 ENOG4105CJ3 phosphate transporter FX998_13305 ENOG4108M6U Universal stress protein A FX998_13310 ENOG4105DUX Transporter FX998_13315 ENOG4105FFN Specifically methylates the guanosine in position 1516 of 16S rRNA (By similarity) FX998_13320 ENOG4105DGW oligopeptidase A FX998_13325 ENOG4105D6S protein involved in catabolism of external DNA FX998_13330 ENOG4105DC8 reductase FX998_13340 ENOG4105KBH arsR family transcriptional regulator FX998_13345 ENOG4107R5R arsenical pump membrane protein FX998_13350 ENOG4105K89 arsenate reductase FX998_13360 ENOG4105Y4Z Outer Membrane Lipoprotein FX998_13370 ENOG4105KT7 mgtC SapB transporter FX998_13375 ENOG4105XXV Acid-resistance protein FX998_13380 ENOG41060V2 Acid-resistance protein FX998_13385 ENOG4108YK4 Acid-resistance membrane protein FX998_13390 ENOG4106WJ0 Regulates the expression of several genes involved in acid resistance. Required for the expression of gadA and gadBC, among others, regardless of media or growth conditions. Binds directly to the 20 bp GAD box found in the control regions of both loci FX998_13400 ENOG4105C1P efflux transporter, rnd family, mfp subunit FX998_13405 ENOG4105BZS acriflavin resistance protein FX998_13410 ENOG4105D3F AraC Family Transcriptional Regulator FX998_13415 ENOG4108NKV transcriptional regulator FX998_13420 ENOG4105CVK Glutamate decarboxylase FX998_13425 ENOG4105CA0 peroxidase FX998_13430 ENOG4105E53 ec 3.2.1.28 FX998_13435 ENOG4106S2D Transcriptional regulator FX998_13440 ENOG4105CBN LysR family transcriptional regulator FX998_13445 ENOG4107H3J ribonuclease FX998_13450 ENOG4105CSH Transporter FX998_13455 ENOG41066T0 asmA family FX998_13460 ENOG4105CMB EAL domain-containing protein FX998_13465 ENOG4107SS6 2-dehydro-3-deoxygluconokinase FX998_13470 ENOG4105CS0 peptidase FX998_13480 ENOG4105BZU Histidine kinase FX998_13485 ENOG4105EJG cellulose synthase FX998_13490 ENOG4105K2Z endo-1,4-d-glucanase (EC 3.2.1.4) FX998_13495 ENOG4107EEX Cellulose synthase regulator protein FX998_13500 ENOG4107QZ7 Cellulose synthase catalytic subunit FX998_13510 ENOG410661M cytoplasmic protein FX998_13515 ENOG4105U74 cellulose biosynthesis protein BcsE FX998_13520 ENOG4105WQA Cellulose biosynthesis protein BcsF FX998_13525 ENOG4105D1V cellulose synthase operon protein YhjU FX998_13540 ENOG4105C44 Serine transporter FX998_13545 ENOG4108JQ7 (ABC) transporter FX998_13550 ENOG4105C3U ABC transporter FX998_13555 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FX998_13560 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component FX998_13570 ENOG4105DEF Extracellular solute-binding protein, family 5 FX998_13580 ENOG4105DIJ Phosphoethanolamine transferase FX998_13585 ENOG4105FCD Major Facilitator FX998_13590 ENOG4105EAX Putative lipase FX998_13595 ENOG4108R3E Dna-3-methyladenine glycosylase i FX998_13600 ENOG4105HNP -acetyltransferase FX998_13605 ENOG4107QY8 reductase FX998_13610 ENOG4108ZG0 Ompa motb domain protein FX998_13620 ENOG4106JH6 (LipO)protein FX998_13625 ENOG4105MVF Transcriptional regulator FX998_13630 ENOG4105VEQ Cold shock protein FX998_13635 ENOG41060TC Hok gef cell toxic protein FX998_13640 ENOG4105DQ6 Transposase FX998_13650 ENOG4108HMW glycyl-tRNA synthetase, alpha subunit FX998_13655 ENOG4105RGS lipoprotein ysaB FX998_13660 ENOG4105MEV Acyl-transferase FX998_13665 ENOG4108Z12 YiaAB two helix domain-containing protein FX998_13670 ENOG410688U Inner membrane protein yiaB FX998_13675 ENOG4105CMG Carbohydrate kinase FX998_13685 ENOG4105DFW ABC transporter FX998_13690 ENOG4105C2J ABC transporter FX998_13695 ENOG4107RNG ABC transporter FX998_13700 ENOG4105T16 Transcriptional regulator (AraC family) FX998_13705 ENOG4108UR8 BAX protein FX998_13710 ENOG4107T9C Alpha amylase catalytic region FX998_13715 ENOG4105JKW Valine--pyruvate aminotransferase FX998_13720 ENOG4108XIB electron transport protein ysaA FX998_13725 ENOG4105J4Q Transcriptional regulator FX998_13735 ENOG4108R66 Conserved Protein FX998_13740 ENOG4105XDZ Tripartite ATP-independent periplasmic transporter FX998_13745 ENOG4105CG6 trap dicarboxylate transporter dctm subunit FX998_13750 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit FX998_13755 ENOG4105CMG Carbohydrate kinase FX998_13760 ENOG4105H6Q decarboxylase FX998_13765 ENOG41064BZ L-xylulose 5-phosphate 3-epimerase FX998_13770 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase FX998_13780 ENOG4105GNX MltA-interacting MipA family protein FX998_13785 ENOG4108Q2M Transcriptional regulator FX998_13790 ENOG4105EFX secretion protein, HlyD family FX998_13795 ENOG4105KK7 inner membrane protein YiaW FX998_13805 ENOG4105C26 Dehydrogenase FX998_13810 ENOG4105C0A alcohol dehydrogenase FX998_13815 ENOG4105EM7 Selenocysteine-specific translation elongation factor FX998_13825 ENOG4108U78 Glutathione S-transferase FX998_13830 ENOG4105CNA YD repeat protein FX998_13835 ENOG4105NUP lyase containing HEAT-repeat FX998_13875 ENOG4105EFX secretion protein, HlyD family FX998_13880 ENOG4105FP6 Protein of unknown function (DUF3302) FX998_13885 ENOG4105CTS PTS system mannitol-specific FX998_13895 ENOG4105E61 Mannitol repressor protein FX998_13905 ENOG4108YYI Protein of unknown function (DUF2810) FX998_13910 ENOG4105DAA L-lactate FX998_13915 ENOG41073TP transcriptional regulator FX998_13925 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) FX998_13930 ENOG4105D7W serine acetyltransferase FX998_13945 ENOG4105VW4 glutaredoxin 3 FX998_13950 ENOG4107YZP Rhodanese domain protein FX998_13960 ENOG41063SB peptidase FX998_13965 ENOG4105PXI polysaccharide deacetylase FX998_13970 ENOG4105K64 Glycosyl transferase, family 2 FX998_13980 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) FX998_13990 ENOG4105XA0 heptosyltransferase ii FX998_13995 ENOG4105D16 lipopolysaccharide heptosyltransferase i FX998_14000 ENOG4108FRV O-antigen ligase FX998_14005 ENOG4107XB0 Lipopolysaccharide 1,2-N-acetylglucosaminetransferase FX998_14010 ENOG4108QD8 lipopolysaccharide core biosynthesis protein FX998_14015 ENOG4108PDR lipopolysaccharide core biosynthesis protein FX998_14020 ENOG4105X1N Glycosyl transferase family 8 FX998_14025 ENOG4106AH0 Glycosyl Transferase FX998_14030 ENOG4107XU6 Glycosyl transferase (Group 1 FX998_14035 ENOG4105X1N Glycosyl transferase family 8 FX998_14040 ENOG4107543 (lipo)polysaccharide FX998_14045 ENOG4107RJ7 Glycosyl transferase (Group 1 FX998_14050 ENOG4105DKP glycosyl transferase, family 9 FX998_14055 ENOG4105D8A 3-Deoxy-D-manno-octulosonic-acid transferase FX998_14070 ENOG4105W0E 50S ribosomal protein L33 FX998_14085 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase FX998_14110 ENOG4105DSJ YicC domain protein FX998_14120 ENOG4105F5P DNA-damage-inducible protein d FX998_14125 ENOG4105EN6 Membrane FX998_14130 ENOG410649J Catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction (By similarity) FX998_14135 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) FX998_14140 ENOG4105VFG Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) FX998_14145 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) FX998_14150 ENOG4105FE8 tRNA (Guanosine-2'-O-)-methyltransferase FX998_14155 ENOG4105CB5 ATP-dependent DNA helicase recG FX998_14160 ENOG4105D6U Sodium Glutamate Symporter FX998_14165 ENOG4105C2W permease FX998_14170 ENOG4105JV1 AsmA family FX998_14175 ENOG4105CJQ hydrolase, family 31 FX998_14180 ENOG4105CT4 transporter FX998_14195 ENOG4105S8Q sugar efflux transporter FX998_14200 ENOG4108UZ3 Transporter FX998_14205 ENOG4105D01 (LipO)protein FX998_14210 ENOG4105T8A Uncharacterized protein YicS FX998_14220 ENOG4108SAJ Protein of unknown function (DUF1198) FX998_14225 ENOG4105C7N Xanthine uracil vitamin C permease FX998_14235 ENOG4105CXY transporter FX998_14240 ENOG4105CXY transporter FX998_14245 ENOG4105BZU Histidine kinase FX998_14250 ENOG4108KX4 response regulator FX998_14255 ENOG4105M71 acetolactate synthase 1 regulatory subunit FX998_14260 ENOG4105C7K acetolactate synthase FX998_14280 ENOG4105E5M Multidrug resistance protein D FX998_14285 ENOG4105J13 transcriptional regulator FX998_14290 ENOG4105JP4 Inner membrane protein yidG FX998_14295 ENOG4105VG5 Membrane FX998_14300 ENOG4106DRA Inner membrane protein YidI FX998_14305 ENOG4105CBG Sulfatase FX998_14310 ENOG4107RUZ Sss sodium solute transporter superfamily FX998_14315 ENOG4108AHD Transcriptional regulator FX998_14325 ENOG4105CI1 PTS System FX998_14330 ENOG4105FDP GntR family transcriptional regulator FX998_14350 ENOG4105R2A (LipO)protein FX998_14355 ENOG4105D99 atp gtp-binding protein FX998_14360 ENOG4107WAP fad NAD(P)-binding domain FX998_14365 ENOG4105DJB Major Facilitator Superfamily FX998_14375 ENOG4108RTU Aldolase FX998_14380 ENOG4105EI3 2-dehydro-3-deoxygalactonokinase EC 2.7.1.58 FX998_14385 ENOG4105EMF GntR family transcriptional regulator FX998_14390 ENOG410657R replicase EC 2.7 FX998_14395 ENOG410667J hydrolase FX998_14400 ENOG4105VP5 Bacterial protein of unknown function (DUF937) FX998_14405 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) FX998_14415 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) FX998_14465 ENOG4108P6C Tryptophan transporter of low affinity FX998_14480 ENOG4105E8Q phosphopantetheinyl transferase FX998_14485 ENOG4108YYH Nadph-dependent fmn reductase FX998_14490 ENOG4105C7N Xanthine uracil vitamin C permease FX998_14495 ENOG4107UB3 HAD-superfamily hydrolase subfamily IA variant 3 FX998_14500 ENOG4106HGK Inner membrane protein yieI FX998_14510 ENOG4105E5H Transposase FX998_14515 ENOG4108YXQ IS66 Orf2 family protein FX998_14525 ENOG4106611 bacteriocin immunity FX998_14530 ENOG4107VKM 6-phosphogluconolactonase FX998_14535 ENOG4105DYC esterase FX998_14545 ENOG4105CS2 ec 3.2.1.21 FX998_14550 ENOG4105C5Y PTS System FX998_14555 ENOG4105CID antiterminator FX998_14560 ENOG4108UTW Plays a role in the regulation of phosphate uptake FX998_14565 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) FX998_14570 ENOG4105E2Z phosphate ABC transporter (Permease FX998_14575 ENOG4105C8U phosphate abc transporter FX998_14580 ENOG4107QMV Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity) FX998_14585 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) FX998_14625 ENOG4105KY6 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) FX998_14635 ENOG4105GXX Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit I associates with the membrane and may be involved with cation translocation FX998_14650 ENOG4105QTB Flavodoxin FX998_14655 ENOG4108VVK transcriptional Regulator, AsnC FX998_14665 ENOG4105EV2 VWA domain protein interacting with AAA ATPase FX998_14680 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) FX998_14685 ENOG4105C2J ABC transporter FX998_14690 ENOG4105CNN ABC, transporter FX998_14695 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator FX998_14700 ENOG4108RVA ribokinase FX998_14705 ENOG4105ETE Transcriptional regulator (LacI family FX998_14710 ENOG4105C0R drug resistance transporter emrb qaca subfamily FX998_14715 ENOG4107EJG GntR family transcriptional regulator FX998_14755 ENOG4108WFC UPF0438 protein yifE FX998_14760 ENOG4105C0P Mg chelatase subunit ChlI FX998_14780 ENOG4105P3Y Acetolactate synthase 2 regulatory subunit FX998_14785 ENOG4105CM2 brancheD-chain amino acid aminotransferase FX998_14795 ENOG4105C7B Threonine dehydratase FX998_14800 ENOG4105EMY transcriptional regulator FX998_14810 ENOG4105KQ5 peptidylprolyl cis-trans isomerase FX998_14820 ENOG4105C4R Atp-dependent dna helicase FX998_14825 ENOG4105C9X ppx gppa phosphatase FX998_14835 ENOG4105K63 Thioredoxin FX998_14850 ENOG4105ESV Glycosyl transferase, family 4 FX998_14855 ENOG4105SFE lipopolysaccharide biosynthesis protein FX998_14860 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase FX998_14865 ENOG4108IJ1 Dehydrogenase FX998_14870 ENOG4105C1B dTDP-glucose 4-6-dehydratase FX998_14875 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) FX998_14880 ENOG4108WJ1 acetyltransferase FX998_14885 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase FX998_14890 ENOG4105EGZ biosynthesis protein FX998_14895 ENOG4105F18 Catalyzes the synthesis of Und-PP-GlcNAc-ManNAcA-Fuc4NAc (Lipid III), the third lipid-linked intermediate involved in ECA synthesis (By similarity) FX998_14910 ENOG4105C85 amino acid FX998_14935 ENOG4105C4X radical SAM domain protein FX998_14940 ENOG4105ENH Sulfatase FX998_14945 ENOG410601J HemY protein FX998_14950 ENOG4105ECF c-methyltransferase FX998_14955 ENOG41076E6 Uroporphyrinogen-III Synthase FX998_14965 ENOG4107T0K Adenylate cyclase FX998_14980 ENOG4105S7Z (LipO)protein FX998_14990 ENOG4105CT0 Protein of unknown function, DUF484 FX998_15000 ENOG4105DFC had-superfamily hydrolase, subfamily ia, variant FX998_15005 ENOG4105C4R Atp-dependent dna helicase FX998_15010 ENOG4108T58 Mg2 transport protein CorA FX998_15015 ENOG4107QUT magnesium and cobalt transport protein CorA FX998_15020 ENOG4105NRM Membrane FX998_15025 ENOG4106WR8 Inner membrane protein YigG FX998_15030 ENOG4105FR1 rard protein FX998_15035 ENOG4108VUY thioesterase Superfamily protein FX998_15040 ENOG4105HDD phospholipase FX998_15045 ENOG4105C9U ATP-dependent DNA helicase RecQ FX998_15060 ENOG4108EUD Lysophospholipase FX998_15065 ENOG4105DQF Hydrolase FX998_15070 ENOG4105EMK carboxylate amino acid amine transporter FX998_15075 ENOG4105DZ2 Transcriptional regulator FX998_15080 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) FX998_15085 ENOG4105CDZ Carboxymethylenebutenolidase (EC 3.1.1.45) FX998_15090 ENOG4108I5U Uridine phosphorylase FX998_15095 ENOG4105CGY Dna recombination protein FX998_15105 ENOG4105JC1 sterol-binding domain protein FX998_15115 ENOG4105WKS Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) FX998_15120 ENOG4105X8U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity) FX998_15125 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) FX998_15130 ENOG4105F8V Hydrolase, tatD family FX998_15135 ENOG4105MDZ Transcriptional activator rfaH FX998_15140 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) FX998_15145 ENOG4107QK7 reductase FX998_15150 ENOG4105CHU acetyl-coa acetyltransferase FX998_15165 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein FX998_15170 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) FX998_15175 ENOG4108RR8 protoporphyrinogen oxidase FX998_15210 ENOG4105FNP Molybdopterin-guanine dinucleotide biosynthesis protein b FX998_15215 ENOG4105C6R Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) FX998_15220 ENOG4105PC1 Conserved Protein FX998_15225 ENOG4105E27 serine threonine protein kinase FX998_15230 ENOG4108Z33 Thiol disulfide Interchange Protein FX998_15240 ENOG4106HNH Acyl-transferase FX998_15250 ENOG4105C2M dna polymerase I FX998_15265 ENOG4105D4P Coproporphyrinogen iii oxidase FX998_15270 ENOG4106FIY FX998_15275 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family FX998_15280 ENOG4105CUX Signal transduction histidine kinase FX998_15285 ENOG4105C5F glutamine synthetase FX998_15295 ENOG4108K85 Transcriptional regulator FX998_15300 ENOG4108KHF Resistance protein FX998_15305 ENOG4105R9B Major Facilitator FX998_15310 ENOG4108KUC Outer membrane channel protein that allows an efficient diffusion of low-molecular-weight solutes such as small sugars and tetraglycine. However, the specific substrate recognized by the OmpL channel is FX998_15315 ENOG4105CT4 transporter FX998_15320 ENOG4105CT4 transporter FX998_15325 ENOG4105CJQ hydrolase, family 31 FX998_15330 ENOG4107WI4 Aldose-1-epimerase FX998_15335 ENOG4107QKS N-acylglucosamine 2-epimerase FX998_15340 ENOG4105D2M Aldolase FX998_15345 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase FX998_15350 ENOG4108MGF sugar kinase FX998_15355 ENOG4105E98 transcriptional regulator DeoR family FX998_15360 ENOG4105EJU HAD-superfamily hydrolase subfamily IA variant 3 FX998_15375 ENOG4105SUU thioesterase domain FX998_15380 ENOG4106UEE Transcriptional regulator FX998_15385 ENOG41068KX affects formate dehydrogenase-N FX998_15395 ENOG4108MG3 formate dehydrogenase FX998_15400 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein FX998_15415 ENOG4108V87 frv operon regulatory protein FX998_15420 ENOG4106C3V frv operon regulatory protein FX998_15425 ENOG4105CN9 Peptidase m42 family protein FX998_15430 ENOG4105DM4 PTS System FX998_15435 ENOG41064BA PTS system, fructose-specific, IIA component FX998_15475 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) FX998_15485 ENOG4108RPX mosc domain containing protein FX998_15490 ENOG4105E0F Histidine kinase FX998_15495 ENOG4105E3W Two component transcriptional regulator (Winged helix family FX998_15500 ENOG4105FMW periplasmic FX998_15505 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) FX998_15575 ENOG4108YXQ IS66 Orf2 family protein FX998_15580 ENOG4105E5H Transposase FX998_15585 ENOG4108C33 Resolvase FX998_15625 ENOG4105ZTC transcriptional activator, Ogr delta FX998_15650 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein FX998_15665 ENOG4105EBK exported protein FX998_15670 ENOG4108VTS Membrane FX998_15675 ENOG41065TG regulatoR FX998_15685 ENOG4105DP0 ferredoxin-NADP reductase FX998_15690 ENOG4105CBT Fructose-1,6-bisphosphatase FX998_15700 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) FX998_15715 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase FX998_15720 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) FX998_15730 ENOG41063M6 Cell Division Protein FX998_15735 ENOG4105ETE Transcriptional regulator (LacI family FX998_15740 ENOG4105C25 Primosomal protein n' FX998_15750 ENOG4107S01 Repressor protein MetJ FX998_15760 ENOG4105C28 cystathionine FX998_15765 ENOG4105CFH Aspartokinase FX998_15770 ENOG4105SYT Methylenetetrahydrofolate reductase FX998_15775 ENOG4105C1X Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity (By similarity) FX998_15780 ENOG4108Q5Y Membrane FX998_15785 ENOG4108XC3 NADH ubiquinone oxidoreductase FX998_15790 ENOG4105DCT glycerol dehydrogenase FX998_15795 ENOG4107T9Z Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) FX998_15800 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) FX998_15805 ENOG4105DM4 PTS System FX998_15810 ENOG4108YRF PTS System FX998_15815 ENOG4105C6N Formate acetyltransferase FX998_15820 ENOG4108AHH pyruvate formate lyase II activase FX998_15825 ENOG4108XCZ PTS System FX998_15830 ENOG4106R3P AraC family transcriptional regulator FX998_15835 ENOG4105DIJ Phosphoethanolamine transferase FX998_15850 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase FX998_15855 ENOG4105CAS nag kinase FX998_15865 ENOG4105C5Q Transcriptional regulator FX998_15875 ENOG4105EJ2 Transcriptional regulator FX998_15880 ENOG4108Y73 Membrane FX998_15890 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) FX998_15925 ENOG4105D4A Cell wall formation (By similarity) FX998_15930 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase FX998_15965 ENOG4105PM1 preprotein translocase subunit SecE FX998_15970 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) FX998_16005 ENOG410645W Thiamin biosynthesis protein ThiH FX998_16010 ENOG4105D41 biosynthesis protein thiH FX998_16020 ENOG4105WHD thiamine biosynthesis protein ThiS FX998_16025 ENOG4105D06 uba thif-type nad fad binding protein FX998_16060 ENOG4105R2J Conserved Protein FX998_16065 ENOG4105K70 DNA-binding protein FX998_16070 ENOG4108T8B Protein of unknown function (DUF1481) FX998_16075 ENOG4105JBU Binds zinc. Could be an important component of the zinc- balancing mechanism FX998_16080 ENOG4105BZU Histidine kinase FX998_16085 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family FX998_16090 ENOG4105C12 Phosphoribosylglycinamide synthetase FX998_16120 ENOG41062WK cellular response to acidity FX998_16125 ENOG4105K5X acetyltransferase FX998_16130 ENOG4105CVG Homoserine O-transsuccinylase FX998_16135 ENOG4107QP3 malate synthase g FX998_16140 ENOG4108I9X Isocitrate lyase FX998_16155 ENOG41069M3 Transcriptional regulator FX998_16160 ENOG4105C3R Methionine synthase FX998_16165 ENOG4105EAM Na Pi-cotransporter FX998_16175 ENOG4105FE9 pseudouridine synthase FX998_16180 ENOG4108ZR5 Conserved Protein FX998_16185 ENOG4105CFH Aspartokinase FX998_16200 ENOG4108MDC (LipO)protein FX998_16205 ENOG4108Q9C Periplasmic Protein FX998_16210 ENOG4105E3R (LipO)protein FX998_16225 ENOG4107QNK )-transporter FX998_16230 ENOG4105EG2 ABC transporter, permease FX998_16235 ENOG4105D56 permease protein FX998_16240 ENOG4107FKK extracellular solute-binding protein family 1 FX998_16245 ENOG4108IJ9 (ABC) transporter FX998_16255 ENOG4107W52 maltose operon periplasmic protein FX998_16280 ENOG41080IJ Diacylglycerol kinase FX998_16290 ENOG4107R73 Mate efflux family protein FX998_16295 ENOG4105VDW Csbd family FX998_16300 ENOG4105MYN Zinc uptake regulation protein FX998_16315 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) FX998_16320 ENOG4105P4Z Phage shock protein G FX998_16325 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein FX998_16330 ENOG4105CDU Replicative dna helicase FX998_16335 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) FX998_16340 ENOG4105CGF Aromatic amino acid aminotransferase FX998_16350 ENOG4105F0S class B acid phosphatase FX998_16355 ENOG4108YXI Secondary thiamine-phosphate synthase enzyme FX998_16360 ENOG4105MSB protein, conserved in bacteria FX998_16365 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) FX998_16370 ENOG4108UUM single-stranded DNA-binding protein FX998_16375 ENOG4108FPN Integrase FX998_16410 ENOG4105PMV Membrane FX998_16415 ENOG4108M8H domain protein FX998_16420 ENOG4108W3Q Transcriptional regulator FX998_16425 ENOG4108Z4X TRANSCRIPTIONal FX998_16430 ENOG4105C7N Xanthine uracil vitamin C permease FX998_16435 ENOG4105EEQ Na H antiporter FX998_16450 ENOG41062QD Membrane FX998_16455 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) FX998_16465 ENOG4105JJ8 Cytochrome c nitrite reductase, pentaheme subunit FX998_16470 ENOG4105D3S 4Fe-4S Ferredoxin, iron-sulfur binding domain protein FX998_16475 ENOG4105DVI reductase, NrfD FX998_16480 ENOG4108QKW cytochrome c-type biogenesis protein FX998_16490 ENOG4108W0S formate-dependent nitrite reductase complex FX998_16495 ENOG4105CK2 sodium dicarboxylate symporter FX998_16500 ENOG41082ND Uncharacterized protein yjcO FX998_16510 ENOG4105ETP RND efflux system, outer membrane lipoprotein FX998_16515 ENOG4108MI0 Resistance protein FX998_16520 ENOG4105J12 Multidrug resistance protein mdtN FX998_16525 ENOG4106833 FX998_16530 ENOG4105EUZ Beta-lactamase domain protein FX998_16535 ENOG4107TFG D-allose kinase FX998_16540 ENOG4105UP7 3-epimerase FX998_16545 ENOG4105CNN ABC, transporter FX998_16550 ENOG4105C2J ABC transporter FX998_16555 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator FX998_16560 ENOG4105NYY transcriptional regulator, RpiR FX998_16565 ENOG4108YZG isomerase FX998_16570 ENOG4106ZVZ Escherichia coli IMT2125 genomic chromosome, IMT2125 FX998_16575 ENOG4107SA6 carbon-phosphorus lyase complex accessory protein FX998_16580 ENOG410849A acetyltransferase, (GNAT) family FX998_16585 ENOG4105MFQ Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP) (By similarity) FX998_16590 ENOG4105FD8 phosphonate metabolism protein PhnM FX998_16595 ENOG4105HRV phosphonate c-p lyase system protein phnl FX998_16600 ENOG4105ENV phosphonate C-P lyase system protein PhnK FX998_16605 ENOG4105FT8 Phosphonate metabolism FX998_16610 ENOG4105EKV Phosphonate metabolism protein FX998_16615 ENOG4105KZ6 phosphonate C-P lyase system protein PhnH FX998_16620 ENOG4105KQZ Phosphonate C-P lyase system protein PhnG FX998_16625 ENOG4107RJJ Transcriptional regulator FX998_16635 ENOG4105EHI Phosphonate ABC transporter, periplasmic FX998_16640 ENOG4105D5T phosphonate abc transporter FX998_16645 ENOG4108SQ4 Glyoxalase Bleomycin resistance protein (Dioxygenase FX998_16650 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA FX998_16660 ENOG4108YIV FX998_16665 ENOG4105CSH Transporter FX998_16675 ENOG4105ECM Sensor protein basS pmrB FX998_16680 ENOG4105XJC Two component transcriptional regulator (Winged helix family FX998_16685 ENOG4105DIJ Phosphoethanolamine transferase FX998_16690 ENOG4105D5Q Arginine ornithine antiporter FX998_16695 ENOG4106ZGR Transcriptional regulator FX998_16700 ENOG4105CXN decarboxylase FX998_16705 ENOG4108K2B transcriptional regulator FX998_16710 ENOG4105F8D glycoside hydrolase family 4 FX998_16715 ENOG4105CT4 transporter FX998_16720 ENOG4108R5S membrane FX998_16725 ENOG4107GFK fumarate FX998_16730 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter FX998_16735 ENOG4108MRH transcriptional regulatory protein FX998_16740 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism FX998_16745 ENOG4105VR1 Pfam:DUF1271 FX998_16750 ENOG410830R acetyltransferase FX998_16765 ENOG4105CRK lysyL-tRNA synthetase FX998_16770 ENOG4105DUX Transporter FX998_16775 ENOG4105CXN decarboxylase FX998_16780 ENOG4105D5Q Arginine ornithine antiporter FX998_16785 ENOG4108M3R transcriptional activator CadC FX998_16795 ENOG4108SIC Transcriptional regulator FX998_16800 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) FX998_16810 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter FX998_16815 ENOG4108IJ0 Aspartate ammonia-lyase FX998_16820 ENOG4108YH1 overproduction of this protein in Escherichia coli inhibits the F plasmid-mediated exclusion of bacteriophage T7 FX998_16825 ENOG4105DVH amino acid FX998_16840 ENOG4108ZVF (LipO)protein FX998_16845 ENOG4105MTB Uncharacterized protein YjeJ FX998_16850 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein FX998_16860 ENOG4106HKS Entericidin EcnA/B family FX998_16865 ENOG4106BSU Entericidin B FX998_16870 ENOG4105KPY Small multidrug resistance protein FX998_16875 ENOG4105QNF Outer membrane lipoprotein FX998_16880 ENOG41066YJ Beta-lactamase FX998_16895 ENOG4105E33 succinate dehydrogenase FX998_16900 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) FX998_16905 ENOG4105CAP With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P (By similarity) FX998_16910 ENOG4107SC7 Inner membrane transporter yjeM FX998_16915 ENOG4106V5W FX998_16920 ENOG4106CG8 Inner membrane protein YjeO FX998_16925 ENOG4105EGS Mechanosensitive ion channel FX998_16965 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) FX998_16970 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) FX998_16975 ENOG4105K8N protein family UPF0079, ATPase FX998_16980 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase FX998_16995 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) FX998_17000 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) FX998_17005 ENOG4107QJR hflk protein FX998_17010 ENOG4105EPW hflc protein FX998_17030 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) FX998_17040 ENOG4105C2N RNA methyltransferase TrmH family group 3 FX998_17045 ENOG4107HP6 Transcriptional regulator FX998_17050 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) FX998_17055 ENOG4105CSP Major Facilitator Superfamily FX998_17060 ENOG4105CTX dehydratase FX998_17075 ENOG4107VNS Protein of unknown function (DUF2491) FX998_17080 ENOG4105Z6B inner membrane protein yjfl FX998_17085 ENOG4108KXT Conserved Protein FX998_17090 ENOG4106032 Glutathionylspermidine synthase FX998_17095 ENOG4105CSU acyl-Coa dehydrogenase FX998_17100 ENOG4105S17 UPF0379 protein yjfN FX998_17105 ENOG4105WSB biofilm stress and motility protein A FX998_17110 ENOG4108MXZ Esterase FX998_17130 ENOG410907W The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in ascorbate transport FX998_17135 ENOG4106ETB IIa component FX998_17150 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase FX998_17155 ENOG4105R3P Inner membrane protein yagU FX998_17160 ENOG4105KIT UPF0379 protein yjfY FX998_17175 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) FX998_17195 ENOG4108RS6 transposase FX998_17200 ENOG4105D7V transposase FX998_17210 ENOG4105FHY Opacity-associated protein A FX998_17220 ENOG4108V1T peptidylprolyl cis-trans isomerase FX998_17225 ENOG4105C85 amino acid FX998_17235 ENOG4105DXC membrane FX998_17240 ENOG4105ECR NmrA family FX998_17245 ENOG4105KVH Transcriptional regulator FX998_17250 ENOG4107RNS bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase 3'-nucleotidase periplasmic FX998_17255 ENOG4108RNI 3'(2')5'-bisphosphate nucleotidase FX998_17265 ENOG4108UUE Transcriptional regulator FX998_17270 ENOG41061GZ Protein of unknown function (DUF1107) FX998_17275 ENOG4105C37 (CBS) domain FX998_17285 ENOG4105CFU surface antigen FX998_17290 ENOG4105MA0 exported protein FX998_17295 ENOG4108ZHD aig2 family FX998_17300 ENOG41087RY SpoVT_AbrB FX998_17305 ENOG4105MZG transcriptional modulator of maze toxin, mazf FX998_17310 ENOG4105F0N pyrophosphate phospho-hydrolase FX998_17315 ENOG4107R5U Periplasmic binding protein LacI transcriptional regulator FX998_17320 ENOG4105C2J ABC transporter FX998_17325 ENOG4107R9N ABC transporter FX998_17330 ENOG41062B0 ABC transporter, permease FX998_17340 ENOG4105DFU Cell wall formation (By similarity) FX998_17350 ENOG4105CMS peptidase U62, modulator of DNA gyrase FX998_17360 ENOG4108RDD Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine (By similarity) FX998_17365 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase FX998_17370 ENOG4105CG3 alpha amylase, catalytic region FX998_17375 ENOG4105C5Y PTS System FX998_17380 ENOG4105D4X repressor FX998_17390 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic FX998_17395 ENOG4105KME endoribonuclease L-psp FX998_17410 ENOG41077AM PyrBI operon attenuator FX998_17415 ENOG4108UQ8 endoribonuclease L-psp FX998_17420 ENOG4105F6U Short-chain dehydrogenase reductase Sdr FX998_17425 ENOG4108XFH Transcriptional regulator FX998_17430 ENOG4105XEP YhcH YjgK YiaL family protein FX998_17455 ENOG4105KQT Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome (By similarity) FX998_17460 ENOG4108MJ3 acetyltransferase FX998_17465 ENOG4108M3P Membrane FX998_17470 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) FX998_17475 ENOG4105MYG DNA polymerase iii, chi subunit FX998_17485 ENOG4108M8S permease YjgP YjgQ family protein FX998_17490 ENOG4108K5H permease YjgP YjgQ family protein FX998_17495 ENOG4105D7A ATP-binding protein FX998_17500 ENOG4105DQ4 alcohol dehydrogenase FX998_17575 ENOG4107RRE RNA-directed DNA polymerase FX998_17590 ENOG4105EKQ RNA-directed DNA polymerase FX998_17610 ENOG4108WUH Transcriptional regulator, TetR family FX998_17620 ENOG4105EXU Membrane FX998_17630 ENOG4105C94 Transporter FX998_17640 ENOG4105NWR lipid A biosynthesis (Kdo)2-(Lauroyl)-lipid IVA acyltransferase FX998_17645 ENOG4108MJ5 VirK protein FX998_17650 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) FX998_17655 ENOG4107BJW polysaccharide deacetylase FX998_17670 ENOG4105EKQ RNA-directed DNA polymerase FX998_17685 ENOG4105E0A ABC, transporter FX998_17690 ENOG4108IHU transport system permease protein FX998_17695 ENOG4105DQ5 transport system permease protein FX998_17700 ENOG4108HUF Transporter FX998_17705 ENOG4105GAV receptor FX998_17710 ENOG4108S3W Anti-feci sigma factor, fecr FX998_17715 ENOG4108SF5 RNA Polymerase FX998_17755 ENOG4105E5H Transposase FX998_17760 ENOG4108YXQ IS66 Orf2 family protein FX998_17790 ENOG41069FU Outer membrane channel protein allowing the entry of N- acetylneuraminic acid (Neu5Ac, the most abundant sialic acid on host cell surfaces) into the bacteria FX998_17810 ENOG4107EFN gluconate transport system permease 3 FX998_17820 ENOG4105DEI Mannitol dehydrogenase FX998_17825 ENOG4105C6F GntR Family Transcriptional Regulator FX998_17845 ENOG4107YNJ LysR family Transcriptional regulator FX998_17850 ENOG4105DYB Isoaspartyl dipeptidase FX998_17855 ENOG4108P2H Inner membrane protein YjiG FX998_17860 ENOG41074DU domain protein FX998_17870 ENOG4105CBP Major Facilitator FX998_17885 ENOG4105CIZ coA-substrate-specific enzyme activase FX998_17890 ENOG4105DCU 2-hydroxyglutaryl-CoA dehydratase FX998_17895 ENOG4106BRA Membrane FX998_17900 ENOG41083G8 Multidrug resistance protein MdtM FX998_17920 ENOG4105CKI cobalamin synthesis protein FX998_17925 ENOG4105VCD cytoplasmic protein FX998_17930 ENOG4105D22 carbon starvation protein FX998_17935 ENOG4105C8Q Methyl-accepting chemotaxis FX998_17940 ENOG4108I5G Major Facilitator superfamily FX998_17945 ENOG410617M Transcriptional regulator FX998_17950 ENOG4105CPQ Dehydrogenase FX998_17960 ENOG4105RI1 glycoprotein receptor FX998_17965 ENOG4106CVF DNA replication protein FX998_17980 ENOG4105DWK Membrane FX998_17985 ENOG4108N8T regulatoR FX998_17990 ENOG4108T94 DNA-binding transcriptional activator BglJ FX998_17995 ENOG4108819 ferric iron reductase FX998_18000 ENOG4105YBH Protein of unknown function (DUF1435) FX998_18010 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) FX998_18015 ENOG4108WPU DNA polymerase III subunit psi FX998_18020 ENOG4105KEG ribosomal-protein-alanine acetyltransferase FX998_18025 ENOG4105PAD Hydrolase FX998_18035 ENOG4105K3G Periplasmic Protein FX998_18045 ENOG4108NRW Phospholipase, patatin family FX998_18050 ENOG4105EYA deoxyribonuclease FX998_18055 ENOG41076CZ activating enzyme FX998_18060 ENOG4105G0K glycine radical enzyme YjjI family FX998_18090 ENOG4107RMF Catalyzes both the ATP-dependent activation of exogenously supplied lipoate to lipoyl-AMP and the transfer of the activated lipoyl onto the lipoyl domains of lipoate-dependent enzymes (By similarity) FX998_18095 ENOG4105EAC phosphoserine phosphatase FX998_18100 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) FX998_18105 ENOG4107VZS Nicotinamide-nucleotide adenylyltransferase FX998_18110 ENOG4105C5H ABC transporter FX998_18115 ENOG4107SC1 transglycosylase FX998_18135 ENOG4105UEI Transcriptional Regulator AraC Family FX998_18140 ENOG4108RH0 Crea protein FX998_18145 ENOG4105E3W Two component transcriptional regulator (Winged helix family FX998_18150 ENOG4105EB3 Histidine kinase FX998_18155 ENOG4105CT7 inner membrane cred family protein FX998_18160 ENOG41065U4 response regulator FX998_18165 ENOG410759A FX998_18170 ENOG4106FVC RNA methyltransferase FX998_18180 ENOG4105CFH Aspartokinase FX998_18190 ENOG4105D98 threonine synthase FX998_18195 ENOG41062C6 Protein of unknown function (DUF2502) FX998_18200 ENOG4105D1Q UPF0246 protein FX998_18205 ENOG4105BZG amino acid carrier protein FX998_18215 ENOG4108RIR Molybdenum cofactor biosynthesis protein FX998_18220 ENOG4106HK8 GPR1 FUN34 yaaH family protein FX998_18225 ENOG4108QUJ UPF0174 protein YaaW FX998_18245 ENOG4108SER Transposase FX998_18250 ENOG4105WI6 cell killing protein encoded within cryptic prophage FX998_18255 ENOG4105DQ6 Transposase FX998_18265 ENOG41063Z6 transcriptional regulator, lysR family FX998_18290 ENOG410647N response to DNA damage stimulus FX998_18295 ENOG4105DTN riboflavin biosynthesis protein ribF FX998_18300 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) FX998_18310 ENOG41090X3 Peptidyl-prolyl cis-trans isomerase FX998_18330 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain FX998_18335 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain FX998_18340 ENOG4108XNW Transcriptional activatory protein CaiF FX998_18350 ENOG4106YT9 Enoyl-CoA hydratase FX998_18385 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase FX998_18390 ENOG4105IBM Could be part of an electron transfer system required for anaerobic carnitine reduction. Could be a 3Fe-4S cluster- containing protein FX998_18395 ENOG4105C54 Major Facilitator superfamily FX998_18410 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) FX998_18435 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) FX998_18440 ENOG4105E7H involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity) FX998_18445 ENOG41066UG Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host (By similarity) FX998_18460 ENOG4105D3G Pseudouridine synthase FX998_18470 ENOG4105CQ2 DNA polymerase FX998_18475 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase FX998_18480 ENOG4105CAC Catalyzes the conversion of L-arabinose to L-ribulose (By similarity) FX998_18485 ENOG4105EF1 ribulokinase FX998_18490 ENOG41063TF transcriptional regulator (AraC FX998_18495 ENOG4108KF1 Membrane FX998_18500 ENOG4107T0D ABC, transporter FX998_18505 ENOG4106SMU thiamine transporter membrane protein FX998_18510 ENOG4105DP9 ABC transporter FX998_18515 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) FX998_18525 ENOG4105S8Q sugar efflux transporter FX998_18540 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) FX998_18555 ENOG41064T2 transcriptional regulator, lysR family FX998_18565 ENOG4105C7K acetolactate synthase FX998_18570 ENOG4108ZP8 Acetolactate synthase small subunit FX998_18580 ENOG4107B7Y DNA-binding transcriptional regulator FruR FX998_18585 ENOG4108V6E Cell division protein mraZ FX998_18595 ENOG41063Y6 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) FX998_18600 ENOG4105CJN penicillin-binding protein FX998_18605 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) FX998_18610 ENOG4108EQQ Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity) FX998_18625 ENOG4105CNI cell division protein FtsW FX998_18640 ENOG4105CPF Cell wall formation (By similarity) FX998_18645 ENOG4105K7E Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity) FX998_18650 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) FX998_18655 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) FX998_18675 ENOG4105M6F mutator MutT protein FX998_18690 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) FX998_18700 ENOG4105D7Q type ii secretion system FX998_18705 ENOG4107QHF type ii secretion system protein e FX998_18710 ENOG4108ZUW Major pilin subunit FX998_18715 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase FX998_18720 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase FX998_18725 ENOG4106A72 regulatory protein AmpE FX998_18730 ENOG4105C85 amino acid FX998_18735 ENOG41073TP transcriptional regulator FX998_18740 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) FX998_18745 ENOG4107QSN dihydrolipoamide acetyltransferase FX998_18750 ENOG4107QN2 dihydrolipoyl dehydrogenase FX998_18755 ENOG4108NST exported protein FX998_18760 ENOG4107QIJ Aconitate hydratase 2 FX998_18780 ENOG4108ZRK uncharacterized protein yacC FX998_18785 ENOG4105E3B Multicopper oxidase FX998_18790 ENOG4105DZG Dehydrogenase FX998_18795 ENOG4108UGV hypoxanthine phosphoribosyltransferase FX998_18800 ENOG41077A9 carbonic anhydrase FX998_18805 ENOG4105DA5 (ABC) transporter FX998_18810 ENOG4105E3A (ABC) transporter FX998_18815 ENOG4108YTN IIa component FX998_18820 ENOG4107BJW polysaccharide deacetylase FX998_18830 ENOG4108A32 Transposase FX998_18865 ENOG4105SN2 fimbrial-like adhesin protein FX998_18870 ENOG4105SYG Fimbrial protein FX998_18875 ENOG4108XEY fimbrial-like adhesin protein FX998_18880 ENOG4105CW0 outer membrane usher protein FX998_18885 ENOG4108VEV chaperone FX998_18895 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase FX998_18900 ENOG4105DJ0 Poly(A) Polymerase FX998_18910 ENOG4108V7X Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters FX998_18920 ENOG4107XID 2'-5' rna ligase FX998_18925 ENOG4105CQ7 ATP-dependent helicase FX998_18930 ENOG4105BZ4 penicillin-binding protein FX998_18935 ENOG4105E0K tonB-dependent siderophore receptor FX998_18940 ENOG4105E0A ABC, transporter FX998_18945 ENOG4105J76 Periplasmic binding protein FX998_18950 ENOG4105S6R Iron-hydroxamate transporter permease subunit FX998_18975 ENOG4105EN6 Membrane FX998_18980 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) FX998_18995 ENOG4105C0H protease FX998_19000 ENOG4108IXP Carbohydrate diacid transcriptional activator CdaR FX998_19015 ENOG4105DIN metallophosphoesterase FX998_19030 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) FX998_19055 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) FX998_19060 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) FX998_19065 ENOG4105KNE Phosphatidate cytidylyltransferase FX998_19070 ENOG4105DZP Membrane-associated zinc metalloprotease FX998_19080 ENOG4108RFI Molecular chaperone that interacts specifically with outer membrane proteins, thus maintaining the solubility of early folding intermediates during passage through the periplasm (By similarity) FX998_19085 ENOG4105D7M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) FX998_19110 ENOG4105C0B DNA polymerase III (alpha subunit) FX998_19120 ENOG4105CXN decarboxylase FX998_19125 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase FX998_19130 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) FX998_19135 ENOG4105M1T rho-binding antiterminator FX998_19145 ENOG4108VWS Yaeq family FX998_19150 ENOG4108YZN class I peptide chain release factor FX998_19155 ENOG4107EII Lipoprotein involved with copper homeostasis and adhesion FX998_19160 ENOG4108UY0 (LipO)protein FX998_19170 ENOG4108R96 Methyltransferase, YaeB family FX998_19175 ENOG4108R8X outer membrane lipoprotein FX998_19180 ENOG4105D01 (LipO)protein FX998_19185 ENOG4108UMI ABC transporter, permease FX998_19190 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) FX998_19195 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase FX998_19230 ENOG4105CV8 reductase FX998_19235 ENOG4105HEI LysR family (Transcriptional regulator FX998_19245 ENOG4105F2W methyltransferase FX998_19250 ENOG4105E9H Lytic Murein transglycosylase FX998_19255 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) FX998_19260 ENOG4105D1A Methyltransferase FX998_19270 ENOG4107RZZ dna polymerase iii epsilon subunit FX998_19280 ENOG410600K aminopeptidase FX998_19295 ENOG4105GMB type VI secretion system effector, hcp1 family FX998_19320 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit FX998_19375 ENOG4108WC9 type VI secretion system effector, hcp1 family FX998_19380 ENOG4105CS6 Rhs element vgr protein FX998_19385 ENOG4105CNA YD repeat protein FX998_19395 ENOG410600T transposase FX998_19400 ENOG4105CZ7 nitrilase cyanide hydratase and apolipoprotein n-acyltransferase FX998_19405 ENOG4108WN0 inhibitor of vertebrate lysozyme FX998_19410 ENOG4107QPN acyl-Coa dehydrogenase FX998_19420 ENOG4105E7A Glutamine amidotransferase FX998_19425 ENOG4105F7V ErfK ybiS ycfS ynhG family protein FX998_19430 ENOG4105VXN addiction module toxin, RelE StbE family FX998_19435 ENOG4105QHH Antitoxin component of a toxin-antitoxin (TA) module. A labile antitoxin that counteracts the effect of the YafQ toxin. YafQ and DinJ together bind their own promoter, and by analogy to other TA modules probably repress its expression FX998_19440 ENOG4108YS0 lipoprotein YafL FX998_19445 ENOG4108UK5 Transposase FX998_19460 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) FX998_19465 ENOG4105UG9 Antitoxin of the YafO-YafN toxin-antitoxin system FX998_19470 ENOG41065DM this blockage is overcome by subsequent expression of antitoxin YafN. Overexpression causes cleavage of a number of mRNAs in a ribosome-dependent fashion. YafO binding to the 50S ribosomal subunit in the translation complex induces mRNA cleavage 3' to the region protected by the ribosome FX998_19475 ENOG4108HYG acetyltransferase FX998_19485 ENOG4108S2Y peptide Chain Release factor FX998_19490 ENOG4105CIN aminoacyl-histidine dipeptidase FX998_19510 ENOG4105FCK Membrane FX998_19535 ENOG4105DFP Integrase FX998_19555 ENOG4105XB7 anti-repressor protein FX998_19660 ENOG4107XAN XdhC and CoxI family FX998_19665 ENOG4105C7W Xanthine dehydrogenase FX998_19670 ENOG4105DIP Molybdopterin dehydrogenase FAD-binding FX998_19675 ENOG4107XKX isoquinoline 1-oxidoreductase, alpha subunit FX998_19680 ENOG4105R3P Inner membrane protein yagU FX998_19685 ENOG4105PI0 Ferredoxin FX998_19690 ENOG4108UD7 cell wall organization FX998_19695 ENOG4106PYX Receptor FX998_19700 ENOG4108N3D putative enzyme FX998_19710 ENOG4108GWT fimbrillin MatB FX998_19715 ENOG4106JB4 Represses expression of the flagellar master operon flhDC, and consequently prevents flagellum biosynthesis and motility. Acts by binding to the regulatory region of the flhDC operon FX998_19730 ENOG4105NRA 50s ribosomal protein l31 type b FX998_19760 ENOG4108KBJ Inner membrane protein YkgB FX998_19765 ENOG41066GK UPF0379 protein ykgI FX998_19770 ENOG4107QN2 dihydrolipoyl dehydrogenase FX998_19775 ENOG4108K01 transcriptional regulator FX998_19780 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) FX998_19785 ENOG4107QR9 Iron-sulfur cluster binding protein FX998_19790 ENOG4108ZZK Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source (By similarity) FX998_19800 ENOG4105CZ6 Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine (By similarity) FX998_19805 ENOG4105C26 Dehydrogenase FX998_19810 ENOG4108MHR Repressor involved in choline regulation of the bet genes (By similarity) FX998_19815 ENOG4105C94 Transporter FX998_19825 ENOG4105BZU Histidine kinase FX998_19830 ENOG4108NUU Transcriptional regulator FX998_19835 ENOG4105SZ2 membrAne FX998_19840 ENOG4107SNB ankyrin repeat protein YahD FX998_19845 ENOG4105N16 Protein of unknown function (DUF2877) FX998_19850 ENOG4107R1Q Membrane protein FdrA FX998_19855 ENOG4107REC cytoplasmic protein FX998_19865 ENOG4105C5B carbamate kinase FX998_19870 ENOG4105DZC cytosine deaminase FX998_19875 ENOG4105DQ4 alcohol dehydrogenase FX998_19890 ENOG4105E82 cytochrome subunit of dehydrogenase FX998_19895 ENOG4105TDT uncharacterized protein yahO FX998_19900 ENOG4108JU7 Transcriptional regulator FX998_19905 ENOG4105CR4 methylisocitrate lyase FX998_19910 ENOG4105BZN citrate synthase FX998_19915 ENOG4105DXD 2-methylcitrate dehydratase FX998_19920 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) FX998_19925 ENOG4105DQW permease for cytosine purines, uracil, thiamine, allantoin FX998_19930 ENOG4105DZC cytosine deaminase FX998_19935 ENOG4105DND Transcriptional regulator FX998_19940 ENOG4107B2H carbonic anhydrase FX998_19945 ENOG4108V7B Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide (By similarity) FX998_19950 ENOG4105DJ2 Major Facilitator Superfamily FX998_19955 ENOG4108UW5 maltose o-acetyltransferase FX998_19960 ENOG4105U0F oligosaccharide H symporter, major facilitator superfamily (MFS) FX998_19965 ENOG4105CNT hydrolase family 2 FX998_19970 ENOG4105ETE Transcriptional regulator (LacI family FX998_19975 ENOG4108K2P TRANSCRIPTIONal FX998_19980 ENOG4105E2Q 3-(3-hydroxy-phenyl)propionate hydroxylase FX998_19985 ENOG4105MI0 Catalyzes the non-heme iron(II)-dependent oxidative cleavage of 2,3-dihydroxyphenylpropionic acid and 2,3- dihydroxicinnamic acid into 2-hydroxy-6-ketononadienedioate and 2- hydroxy-6-ketononatrienedioate, respectively (By similarity) FX998_19990 ENOG4106HB6 Alpha beta hydrolase FX998_19995 ENOG4105IKQ hydratase FX998_20010 ENOG4108SC4 )-transporter FX998_20015 ENOG4105IUQ nucleoprotein polynucleotide-associated enzyme FX998_20020 ENOG4105C4W S-formylglutathione hydrolase FX998_20035 ENOG410836F Transposase FX998_20040 ENOG4105SRB Uncharacterized protein yaiO FX998_20050 ENOG4108PBI Polysaccharide metabolism FX998_20055 ENOG4107W19 lmbE family FX998_20065 ENOG4106FTQ Taurine ABC transporter, periplasmic FX998_20070 ENOG4108IY8 ABC, transporter FX998_20075 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component FX998_20080 ENOG4105E2B Taurine dioxygenase FX998_20085 ENOG4105D52 delta-aminolevulinic acid dehydratase FX998_20095 ENOG4108PNB DNA-binding transcriptional regulator FX998_20100 ENOG4107R6D beta-lactam binding protein AmpH FX998_20105 ENOG4108DQG in Escherichia coli SbmA is involved in uptake of microcin J25 FX998_20110 ENOG4107QS8 (LipO)protein FX998_20115 ENOG4105FR5 inner membrane protein YaiY FX998_20120 ENOG4105UNH Membrane FX998_20125 ENOG4105CPF Cell wall formation (By similarity) FX998_20135 ENOG4105G6Z alkaline phosphatase FX998_20140 ENOG4105VIF phosphate starvation-inducible protein FX998_20145 ENOG4105BZU Histidine kinase FX998_20150 ENOG4105II7 pyrroline-5-carboxylate reductase FX998_20165 ENOG4105SS3 FX998_20170 ENOG4105HBA AroM protein FX998_20195 ENOG4105DKQ ROK family FX998_20200 ENOG4105F27 Major Facilitator FX998_20205 ENOG4105EYH Exonuclease FX998_20210 ENOG4107RH8 nuclease SbcCD subunit D FX998_20215 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FX998_20220 ENOG4105BZU Histidine kinase FX998_20225 ENOG4105CWM branched-chain amino acid transport system II carrier protein FX998_20230 ENOG4105C85 amino acid FX998_20235 ENOG4107R28 alpha amylase, catalytic region FX998_20255 ENOG4105VIE preprotein translocase, subunit YajC FX998_20260 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) FX998_20265 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) FX998_20270 ENOG4105N1F Hnh endonuclease FX998_20275 ENOG4105DRB nucleoside-specific channel-forming protein FX998_20280 ENOG4108KIC (LipO)protein FX998_20290 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) FX998_20295 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) FX998_20305 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) FX998_20310 ENOG4108ZAI phosphatidylglycerophosphatase a FX998_20315 ENOG4105CPC Aldo Keto reductase FX998_20325 ENOG4105CTB Polyprenyl synthetase FX998_20340 ENOG4107S0N DJ-1 family FX998_20345 ENOG4108JZF Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) FX998_20355 ENOG4107RDB Major Facilitator FX998_20365 ENOG41090KH cytochrome o ubiquinol oxidase (subunit iv) FX998_20370 ENOG4105CCU oxidase (Subunit III) FX998_20375 ENOG4105BZ9 Cytochrome C oxidase, subunit I FX998_20380 ENOG4105E2S oxidase) subunit II FX998_20385 ENOG4105EYM Major Facilitator superfamily FX998_20390 ENOG4105IEY (LipO)protein FX998_20395 ENOG4105M85 Bola protein FX998_20415 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) FX998_20420 ENOG4105K70 DNA-binding protein FX998_20425 ENOG4105EIN peptidylprolyl cis-trans isomerase FX998_20430 ENOG41083P1 competence protein ComEA helix-hairpin-helix repeat protein FX998_20435 ENOG4108TGP Thioesterase superfamily protein FX998_20445 ENOG4108NFA extracellular solute-binding protein FX998_20455 ENOG4108XM1 transcriptional regulator AsnC family FX998_20460 ENOG4105BZ1 (ABC) transporter FX998_20465 ENOG4105BZ1 (ABC) transporter FX998_20470 ENOG4108YZA Nitrogen regulatory protein pii FX998_20475 ENOG4105BZU Histidine kinase FX998_20480 ENOG4105C29 acyl-CoA thioesterase FX998_20485 ENOG4108MNP Glycoprotein polysaccharide metabolism FX998_20490 ENOG41080UX Methyltransferase FX998_20500 ENOG4105KCV RNA signal recognition particle 4.5S RNA FX998_20505 ENOG41066DG (EAL) domain protein FX998_20510 ENOG4105GSJ Inner membrane protein ylaC FX998_20515 ENOG4108UW5 maltose o-acetyltransferase FX998_20520 ENOG4105KF5 hemolysin expression-modulating protein FX998_20525 ENOG4108UKR Biofilm formation regulator YbaJ FX998_20530 ENOG4105BZS acriflavin resistance protein FX998_20535 ENOG4105C1P efflux transporter, rnd family, mfp subunit FX998_20545 ENOG4105EGS Mechanosensitive ion channel FX998_20550 ENOG4106428 Protein of unknown function (DUF2496) FX998_20555 ENOG4108URS primosomal replication protein n'' FX998_20560 ENOG4105WD1 Membrane FX998_20570 ENOG4107QMP dna polymerase iii subunits gamma and tau FX998_20585 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) FX998_20610 ENOG4107RE1 Inosine-guanosine kinase FX998_20615 ENOG4105CKD glutathione-regulated potassium-efflux system protein FX998_20620 ENOG4105EU0 Major facilitator Superfamily FX998_20625 ENOG4105CGH 5'-nucleotidase FX998_20630 ENOG4108Z66 YbaK ebsC protein FX998_20635 ENOG4105MBR gumn family FX998_20645 ENOG41081XE plasmid maintenance system antidote protein, xre family FX998_20650 ENOG4105C59 p-type ATPase FX998_20655 ENOG4105CSV Glutaminase FX998_20660 ENOG4107RY6 amino acid FX998_20665 ENOG4108Z6Z Transcriptional regulator FX998_20670 ENOG4105G5H Membrane FX998_20675 ENOG4107QX8 SPFH domain, Band 7 family protein FX998_20680 ENOG41083J0 (ABC) transporter FX998_20685 ENOG4105C4B ABC transporter, permease FX998_20690 ENOG4107QR8 Thioredoxin FX998_20695 ENOG4105E1F short-chain dehydrogenase reductase FX998_20700 ENOG4108UJV acyl-CoA thioesterase i FX998_20705 ENOG4108I0Y (ABC) transporter FX998_20710 ENOG4105CV6 ABC transporter, permease FX998_20745 ENOG4107653 Transcriptional regulator FX998_20750 ENOG4108Z2U ureidoglycolate hydrolase FX998_20755 ENOG4108N16 Negative regulator of allantoin and glyoxylate utilization operons. Binds to the gcl promoter and to the allS- allA intergenic region FX998_20760 ENOG41060W2 glyoxylate carboligase FX998_20770 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase FX998_20775 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease FX998_20785 ENOG4105DTE Xanthine uracil vitamin C permease FX998_20790 ENOG4105BZW Glycerate kinase FX998_20795 ENOG4105S0E allantoin catabolism protein FX998_20800 ENOG4105CE7 Amidase, hydantoinase carbamoylase family FX998_20805 ENOG4105DG4 malate L-lactate dehydrogenase FX998_20810 ENOG4107R1Q Membrane protein FdrA FX998_20815 ENOG4107REC cytoplasmic protein FX998_20820 ENOG4105G5A Protein of unknown function (DUF2877) FX998_20825 ENOG4105C5B carbamate kinase FX998_20830 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit FX998_20835 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) FX998_20845 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) FX998_20855 ENOG4105S2T inner membrane protein YbcI FX998_20860 ENOG4105WQ3 Rna-binding protein FX998_20870 ENOG4108WDE Fimbrial protein FX998_20875 ENOG4108AF8 Chaperone FX998_20880 ENOG4105CW0 outer membrane usher protein FX998_20885 ENOG4108M66 Involved in regulation of length and mediation of adhesion of SfmA fimbriae (but not necessary for the production of fimbriae). Seems to be mannose binding adhesin (By similarity) FX998_20890 ENOG4108ZI2 Fimbrial protein FX998_20895 ENOG4108Q9V regulatoR FX998_20910 ENOG4105QUW FX998_20915 ENOG41090FC Bacteriophage N4 receptor, outer membrane subunit FX998_20920 ENOG410802X bacteriophage n4 adsorption protein b FX998_20925 ENOG4105GR3 Histidine kinase FX998_20930 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FX998_20935 ENOG4105ENJ RND efflux system, outer membrane lipoprotein FX998_20940 ENOG410624V efflux system protein FX998_20945 ENOG4105EP1 Efflux transporter rnd family, mfp subunit FX998_20950 ENOG4108IJF Heavy metal efflux pump, CzcA FX998_20955 ENOG4105C85 amino acid FX998_20960 ENOG4105CUY Mechanosensitive ion channel FX998_20965 ENOG4108RCM Nitroreductase FX998_20985 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase FX998_20990 ENOG4105CMR udp-glucose 4-epimerase FX998_21010 ENOG4105CPK Glycosyl transferase (Group 1 FX998_21015 ENOG4105CGN Glycosyl transferase (Group 1 FX998_21020 ENOG4105PFA Catalyzes the conversion of 5-hydroxyuridine (ho5U) to 5-methoxyuridine (mo5U) at position 34 in tRNA (By similarity) FX998_21025 ENOG4107T8Q Glycosyl transferase (Group 1 FX998_21040 ENOG4105HVQ Regulatory factor of maltose metabolism FX998_21080 ENOG4107635 Hok Gef family protein FX998_21085 ENOG4108SER Transposase FX998_21090 ENOG4108TSE Transferase FX998_21095 ENOG4107RNH Outer membrane receptor FepA FX998_21105 ENOG4105E93 esterase FX998_21110 ENOG41085A6 mbth domain-containing protein FX998_21115 ENOG4105C0W non-ribosomal peptide synthetase FX998_21120 ENOG4108QY5 Ferric enterobactin transport protein FX998_21125 ENOG4105E0A ABC, transporter FX998_21130 ENOG4105TVJ transport system, permease FX998_21135 ENOG4105DQ5 transport system permease protein FX998_21145 ENOG4105PEC Iron-enterobactin transporter periplasmic binding protein FX998_21150 ENOG4105E4F Isochorismate synthase FX998_21155 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase FX998_21160 ENOG4105WQI isochorismatase FX998_21165 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase FX998_21170 ENOG4108TZA Required for optimal enterobactin synthesis. Acts as a proofreading enzyme that prevents EntB misacylation by hydrolyzing the thioester bound existing between EntB and wrongly charged molecules (By similarity) FX998_21175 ENOG4105D22 carbon starvation protein FX998_21180 ENOG4105VCD cytoplasmic protein FX998_21185 ENOG4107SCQ Iron-containing alcohol dehydrogenase FX998_21190 ENOG4105CHM Aminotransferase FX998_21195 ENOG4105GTN ParB Domain Protein Nuclease FX998_21200 ENOG4105BZV Phosphoadenosine phosphosulfate reductase FX998_21205 ENOG4105DQS Transcriptional regulator FX998_21210 ENOG4108KHN disulfide isomerase, thiol-disulfide oxidase FX998_21215 ENOG4105D3R alkyl hydroperoxide reductase FX998_21220 ENOG4108JU3 Alkyl hydroperoxide reductase FX998_21225 ENOG4108U51 Universal stress protein FX998_21230 ENOG4105E2A Dehydrogenase FX998_21235 ENOG4105NXH GreA GreB family elongation factor FX998_21240 ENOG4105KTS ribonuclease FX998_21245 ENOG4107QPK )-transporter FX998_21260 ENOG4105CHY citrate lyase, alpha FX998_21265 ENOG4105CI0 Citrate lyase FX998_21275 ENOG4105DUA (citrate (pro-3S)-lyase ligase FX998_21280 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism FX998_21285 ENOG4106YYS transcriptional regulatory protein FX998_21290 ENOG4105CEE C4-dicarboxylate transporter FX998_21295 ENOG41079UR PagP is required both for biosynthesis of hepta-acylated lipid A species containing palmitate and for resistance to cationic antimicrobial peptides (CAMPs). It catalyzes the transfer of a palmitate chain (16 0) from the sn-1 position of a glycerophospholipid to the free hydroxyl group of the (R)-3- hydroxymyristate chain at position 2 of lipid A (endotoxin) (By similarity) FX998_21300 ENOG4105VEQ Cold shock protein FX998_21315 ENOG410607N Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatE shares overlapping functions with TatA (By similarity) FX998_21325 ENOG41064T2 transcriptional regulator, lysR family FX998_21340 ENOG4105DZ1 carboxypeptidase FX998_21345 ENOG4105K6T rare lipoprotein A FX998_21350 ENOG4105CNI cell division protein FtsW FX998_21355 ENOG4105CJN penicillin-binding protein FX998_21365 ENOG4105KEM Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) FX998_21370 ENOG4108TGR phosphatase FX998_21380 ENOG4105DJF DNA polymerase III, delta' subunit FX998_21395 ENOG4107PAI alpha helical protein FX998_21400 ENOG4105EUU Sel1 domain protein repeat-containing protein FX998_21405 ENOG41069CF Protein of unknown function (DUF1266) FX998_21410 ENOG4105QFC Hsc56 co-chaperone of HscC FX998_21415 ENOG4107JFD Sel1 repeat FX998_21420 ENOG41069CF Protein of unknown function (DUF1266) FX998_21425 ENOG4105QFC Hsc56 co-chaperone of HscC FX998_21430 ENOG4105F7F Chaperone FX998_21440 ENOG4105CDA abc transporter atp-binding protein FX998_21445 ENOG4105DRP amino acid AbC transporter FX998_21450 ENOG4105EAD ABC transporter FX998_21455 ENOG4107RP9 extracellular solute-binding protein, family 3 FX998_21460 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) FX998_21465 ENOG4108JU5 Magnesium and cobalt efflux protein FX998_21475 ENOG4105C9A Phoh family FX998_21485 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family FX998_21525 ENOG4105CAQ asparagine synthetase FX998_21530 ENOG4105D4U had-superfamily hydrolase, subfamily iia FX998_21535 ENOG4105E2R ROK family FX998_21540 ENOG4105CE4 GlcNAc 6-P deacetylase FX998_21550 ENOG4105CI1 PTS System FX998_21565 ENOG4105GX6 (LipO)protein FX998_21570 ENOG41090R7 Ferric uptake FX998_21580 ENOG4105MHQ Low-potential electron donor to a number of redox enzymes (By similarity) FX998_21585 ENOG4105NNH LexA regulated protein FX998_21590 ENOG4105EV9 Alpha Beta Hydrolase FX998_21595 ENOG4107CDU Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated (By similarity) FX998_21600 ENOG4107QIX Phosphoglucomutase (EC 5.4.2.2 FX998_21620 ENOG4105D5Q Arginine ornithine antiporter FX998_21635 ENOG4105EEX Two component transcriptional regulator (Winged helix family FX998_21640 ENOG4105C08 Histidine kinase FX998_21665 ENOG4105XIQ Protein of unknown function (DUF2517) FX998_21670 ENOG4105CNA YD repeat protein FX998_21675 ENOG41079JQ Membrane FX998_21685 ENOG4106R09 FX998_21705 ENOG4107SEY Conserved Protein FX998_21710 ENOG4105CVP deoxyribo-dipyrimidine photolyase FX998_21715 ENOG4105DUX Transporter FX998_21720 ENOG4107QNR UPF0135 protein FX998_21725 ENOG4105P4J Allophanate hydrolase, subunit 1 FX998_21730 ENOG4107R7A Allophanate hydrolase subunit 2 FX998_21745 ENOG4108KK1 membrane protein AbrB duplication FX998_21750 ENOG4108MY7 Fimbrial FX998_21755 ENOG4108TTM chaperone FX998_21760 ENOG4106PG1 outer membrane usher protein FX998_21765 ENOG4106UBK fimbrial-like adhesin protein FX998_21770 ENOG4105BZN citrate synthase FX998_21780 ENOG4108UTY succinate dehydrogenase, cytochrome b556 subunit FX998_21785 ENOG4105N1I succinate dehydrogenase, hydrophobic membrane anchor protein FX998_21790 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) FX998_21795 ENOG4105E33 succinate dehydrogenase FX998_21800 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 FX998_21805 ENOG4105C7S Dehydrogenase FX998_21815 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha FX998_21820 ENOG4105FDP GntR family transcriptional regulator FX998_21825 ENOG4105DM4 PTS System FX998_21830 ENOG4105C8I hydrolase, family 38 FX998_21840 ENOG4105C4M (Ubiquinol oxidase) subunit I FX998_21845 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii FX998_21855 ENOG4105KJB cyd operon protein YbgE FX998_21860 ENOG4107YD3 Thioesterase FX998_21865 ENOG4105E02 MotA TolQ exbB proton channel FX998_21870 ENOG4105M8F Biopolymer transport protein exbD tolR FX998_21875 ENOG4108Z82 Cell envelope integrity inner membrane protein TolA FX998_21885 ENOG4105KCK Peptidoglycan-associated lipoprotein FX998_21890 ENOG4105UFD tol-pal system protein YbgF FX998_21940 ENOG4106Z1T Nicotinamide Mononucleotide Transporter FX998_21945 ENOG4105PGM cation diffusion facilitator family transporter FX998_21950 ENOG4105JND homeobox protein FX998_21955 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) FX998_21965 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) FX998_21975 ENOG4105F0Z galactose-1-phosphate uridylyltransferase FX998_21980 ENOG4105CMR udp-glucose 4-epimerase FX998_21985 ENOG4105DKW ABC transporter FX998_21990 ENOG4105F4R Transcriptional regulator mode FX998_21995 ENOG410680R Protein of unknown function (DUF2592) FX998_22000 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein FX998_22005 ENOG4105E0C molybdate abc transporter FX998_22010 ENOG4105CGB Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system (By similarity) FX998_22015 ENOG4108K4B hydrolase FX998_22025 ENOG4105F04 LysR family Transcriptional regulator FX998_22030 ENOG4105C7F AcnD-accessory protein PrpF FX998_22035 ENOG4107QPK )-transporter FX998_22040 ENOG4107QM5 aconitate hydratase FX998_22045 ENOG4105NBR Pectinesterase FX998_22050 ENOG4108V1U phospholipid-binding protein FX998_22055 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) FX998_22065 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) FX998_22070 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) FX998_22075 ENOG4105E78 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) FX998_22085 ENOG4105CHW UPF0052 protein FX998_22095 ENOG4108RIR Molybdenum cofactor biosynthesis protein FX998_22105 ENOG4105M00 molybdopterin converting factor, subunit 1 FX998_22110 ENOG4108ZAF Molybdopterin FX998_22115 ENOG4105HFZ Membrane FX998_22120 ENOG410733J conserved inner membrane protein FX998_22125 ENOG4107UXM Membrane FX998_22130 ENOG4105DZQ phospholipase D Transphosphatidylase FX998_22135 ENOG4105X23 Endonuclease Exonuclease phosphatase FX998_22140 ENOG4105I9U inner membrane protein ybhQ FX998_22145 ENOG4107QWP ABC-2 type transporter FX998_22150 ENOG4107QWP ABC-2 type transporter FX998_22155 ENOG4105CJ1 ABC, transporter FX998_22165 ENOG4107MVR Transcriptional regulator FX998_22170 ENOG4105C1J atp-dependent rna helicase FX998_22175 ENOG4108UV1 cellular component movement FX998_22180 ENOG4105DVT helicase FX998_22185 ENOG4108MTB glycosyl transferase family FX998_22190 ENOG4105DG4 malate L-lactate dehydrogenase FX998_22195 ENOG4105VR4 UPF0379 protein ybiJ FX998_22200 ENOG4105KSC Transcriptional regulator, TraR DksA family FX998_22210 ENOG4108IU3 tonb-dependent siderophore receptor FX998_22215 ENOG4105ZY9 UPF0379 protein ybiM FX998_22225 ENOG4105D8X mechanosensitive ion channel FX998_22230 ENOG4105CDA abc transporter atp-binding protein FX998_22235 ENOG4105E5Q amino acid AbC transporter FX998_22240 ENOG4107R0W ABC transporter FX998_22250 ENOG4107AQZ Membrane FX998_22260 ENOG4108T1M outer membrane protein x FX998_22265 ENOG4108I6E Sulfatase FX998_22275 ENOG4105KST dependent repressor FX998_22280 ENOG4105F4P )-transporter FX998_22285 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein FX998_22290 ENOG4105C5H ABC transporter FX998_22295 ENOG41072TH Protein of unknown function (DUF1479) FX998_22300 ENOG4108HCJ Hydrolase FX998_22305 ENOG4105C6N Formate acetyltransferase FX998_22310 ENOG4105F1A Pyruvate formate-lyase FX998_22315 ENOG4107T9Z Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) FX998_22320 ENOG4105D06 uba thif-type nad fad binding protein FX998_22325 ENOG4105CVM Molybdenum cofactor synthesis domain protein FX998_22330 ENOG4105D44 asparaginase FX998_22335 ENOG4108JQ6 ABC transporter FX998_22340 ENOG4105DEF Extracellular solute-binding protein, family 5 FX998_22350 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FX998_22360 ENOG41064RH membrane protein YliF FX998_22370 ENOG4105UFT Represses biofilm formation in M9C glu and LB glu media but not in M9C and LB media. Seems to act as a global regulator of several genes involved in catabolite repression and stress response and regulation of the uptake and export of signaling pathways. Could be involved the regulation of indole as well as uptake and export of AI-2 through a cAMP-dependent pathway FX998_22375 ENOG4105D8V Glucose sorbosone dehydrogenase FX998_22380 ENOG4108TGY Glutathione S-transferase FX998_22385 ENOG4105DZ1 carboxypeptidase FX998_22390 ENOG4107FB0 transcriptional regulator DeoR family FX998_22395 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase FX998_22400 ENOG4107QF7 multi-drug FX998_22410 ENOG4108HCJ Hydrolase FX998_22415 ENOG4106UW1 Major Facilitator superfamily FX998_22420 ENOG4108RFG Tetr family transcriptional regulator FX998_22430 ENOG4105GWF inner membrane protein YbjM FX998_22435 ENOG41090BQ Glutaredoxin FX998_22440 ENOG4105X20 member of the soxRS regulon which mediates in part the increased levels of superoxide in response to oxidative stress FX998_22445 ENOG4108DBC nitroreductase FX998_22455 ENOG4108RMJ sensory transduction regulator FX998_22460 ENOG4107RUE extracellular solute-binding protein family 1 FX998_22465 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FX998_22470 ENOG4105F38 ABC transporter, permease FX998_22475 ENOG4105D38 putrescine abc transporter FX998_22480 ENOG4105RBQ inner membrane protein ybjO FX998_22490 ENOG4106TNF Periplasmic binding protein FX998_22495 ENOG4105DMR ABC, transporter FX998_22500 ENOG4105GBT ABC transporter FX998_22505 ENOG4106PMH Extracellular solute-binding protein family 3 FX998_22510 ENOG4105E5Z arginine transporter ATP-binding subunit FX998_22515 ENOG41064MM (LipO)protein FX998_22525 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase FX998_22530 ENOG4107VBM 3-beta hydroxysteroid dehydrogenase isomerase FX998_22535 ENOG4105CGD Nad-dependent epimerase dehydratase FX998_22540 ENOG4105C5W Aldolase FX998_22545 ENOG4105C7K acetolactate synthase FX998_22550 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) FX998_22560 ENOG4105DWU Membrane FX998_22565 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) FX998_22570 ENOG4105CPB ATP-dependent endonuclease of the OLD family FX998_22575 ENOG4108MJ5 VirK protein FX998_22580 ENOG4105DJY efflux transporter, rnd family, mfp subunit FX998_22585 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) FX998_22590 ENOG4105VEQ Cold shock protein FX998_22600 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit FX998_22615 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) FX998_22625 ENOG4108JJ8 (ABC) transporter FX998_22630 ENOG4108JJ9 ABC, transporter FX998_22635 ENOG4105C3M thioredoxin reductase FX998_22640 ENOG4105EW9 transcriptional regulator AsnC family FX998_22645 ENOG4105CNU cell division protein FtsK FX998_22655 ENOG4105D1H recombination factor protein RarA FX998_22665 ENOG4107QY8 reductase FX998_22670 ENOG4105QAX Iron-sulfur FX998_22675 ENOG4107KGK dmso reductase anchor subunit FX998_22680 ENOG4105CHJ isochorismatase hydrolase FX998_22690 ENOG4105E5D amino acid FX998_22695 ENOG410642W LysR family Transcriptional regulator FX998_22700 ENOG4108X0B nad(p)h dehydrogenase (quinone) FX998_22705 ENOG4105F1A Pyruvate formate-lyase FX998_22710 ENOG4105C6N Formate acetyltransferase FX998_22715 ENOG4105TMB Formate nitrite transporter FX998_22720 ENOG4105DDY UPF0142 protein ycaO FX998_22725 ENOG4107VMU Membrane FX998_22740 ENOG4108K0D peptidase, M48 FX998_22750 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) FX998_22760 ENOG4108EQH DNA internalization-related competence protein ComEC Rec2 FX998_22765 ENOG4105BZ1 (ABC) transporter FX998_22770 ENOG4105CHD Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity) FX998_22775 ENOG4105T0Z Conserved Protein FX998_22790 ENOG4107VR7 transferase activity, transferring phosphorus-containing groups FX998_22795 ENOG4107S90 membrAne FX998_22800 ENOG4106371 Methyltransferase FX998_22810 ENOG4105DAH Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF (By similarity) FX998_22820 ENOG4105DIT ErfK YbiS YcfS YnhG family protein FX998_22825 ENOG4105EAQ (twin-arginine translocation) pathway signal FX998_22830 ENOG4105C5X domain protein FX998_22835 ENOG4105CGF Aromatic amino acid aminotransferase FX998_22840 ENOG4105FCK Membrane FX998_22855 ENOG4105CD8 aminopeptidase N FX998_22860 ENOG4105E2Y ABC, transporter FX998_22865 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component FX998_22875 ENOG4105GVF (ABC) transporter FX998_22880 ENOG4108UZX fmn reductase FX998_22885 ENOG41071VI Part of the elfADCG-ycbUVF fimbrial operon, which promotes adhesion of bacteria to different abiotic surfaces. ElfA is the major fimbrial subunit produced by this operon FX998_22890 ENOG4106JJN Part of the elfADCG-ycbUVF fimbrial operon, which promotes adhesion of bacteria to different abiotic surfaces. Could be required for the biogenesis of the ElfA fimbriae FX998_22895 ENOG4105CW0 outer membrane usher protein FX998_22900 ENOG4108MDY Fimbrial FX998_22905 ENOG4105Q7J Fimbrial FX998_22910 ENOG4105MX3 Fimbrial FX998_22915 ENOG4106PH7 chaperone FX998_22925 ENOG4108T7E Contributes to the efficiency of the cell division process by stabilizing the polymeric form of the cell division protein FtsZ. Acts by promoting interactions between FtsZ protofilaments and suppressing the GTPase activity of FtsZ (By similarity) FX998_22930 ENOG4105QVC MOSC domain-containing protein FX998_22935 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) FX998_22940 ENOG4105C5H ABC transporter FX998_22945 ENOG4105F1S paraquat-inducible protein a FX998_22950 ENOG4105DY2 Paraquat-inducible protein b FX998_22955 ENOG4108Q2G (LipO)protein FX998_22960 ENOG4105WFT During stationary phase, converts 70S ribosomes to an inactive dimeric form (100S ribosomes) (By similarity) FX998_22970 ENOG4105DAN ATP-dependent protease FX998_22980 ENOG4105UYK outer membrane protein a FX998_22990 ENOG4108RZ1 DNA transformation protein FX998_22995 ENOG4105EM2 membrane FX998_23000 ENOG410901E Membrane FX998_23005 ENOG41088T4 Helicase IV FX998_23020 ENOG4105K4P CoA-binding domain protein FX998_23035 ENOG4105VSY K01512 acylphosphatase EC 3.6.1.7 FX998_23040 ENOG4108Z0T Part of a sulfur-relay system (By similarity) FX998_23045 ENOG4108MN8 Membrane FX998_23055 ENOG4105E3S small subunit FX998_23060 ENOG4105DPX Hydrogenase, large subunit FX998_23065 ENOG4105X7T Ni Fe-hydrogenase, b-type cytochrome subunit FX998_23070 ENOG4108USZ hydrogenase FX998_23075 ENOG4108VXY Hydrogenase-1 operon protein HyaE FX998_23080 ENOG4105MVP hydrogenase-1 operon protein HyaF FX998_23085 ENOG4105C4M (Ubiquinol oxidase) subunit I FX998_23090 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii FX998_23100 ENOG4105D6F Phosphatase FX998_23105 ENOG4105D75 Capsular exopolysaccharide family FX998_23110 ENOG4107ZF2 Phosphatase FX998_23115 ENOG4105DAY polysaccharide export protein FX998_23120 ENOG4105E3R (LipO)protein FX998_23125 ENOG4108W78 Pfam:DUF1017 FX998_23130 ENOG4108Y9B (LipO)protein FX998_23140 ENOG41060EU Cold shock-like protein FX998_23145 ENOG4105VEQ Cold shock protein FX998_23160 ENOG4106H71 Overexpression increases levels of unsaturated fatty acids and suppresses both the temperature-sensitive fabA6 mutation and cold-sensitive secG null mutation FX998_23165 ENOG4105HEE Binding Domain protein FX998_23170 ENOG4105BZU Histidine kinase FX998_23175 ENOG4108SV3 Tmao reductase system periplasmic protein tort FX998_23180 ENOG4106WF9 DNA-binding transcriptional regulator TorR FX998_23185 ENOG4105CUW cytochrome C-TYPE protein FX998_23190 ENOG4107QY8 reductase FX998_23195 ENOG4108SBI Involved in the biogenesis of TorA. Acts on TorA before the insertion of the molybdenum cofactor and, as a result, probably favors a conformation of the apoenzyme that is competent for acquiring the cofactor (By similarity) FX998_23215 ENOG4105D6F Phosphatase FX998_23220 ENOG4105XH3 FX998_23230 ENOG4105XF5 Escherichia coli IMT2125 genomic chromosome, IMT2125 FX998_23235 ENOG4105C2W permease FX998_23250 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) FX998_23275 ENOG4108R86 Transcriptional regulator FX998_23280 ENOG4105C26 Dehydrogenase FX998_23290 ENOG4105CK7 Sodium proline symporter FX998_23295 ENOG4105EKT )-iron permease FX998_23300 ENOG410650H (LipO)protein FX998_23305 ENOG4105DBE peroxidase FX998_23310 ENOG4105D5M phosphate starvation-inducible protein FX998_23315 ENOG4106FQ9 Biofilm PGA synthesis protein PgaD FX998_23320 ENOG4105CND Glycosyl transferase, family 2 FX998_23325 ENOG4107BJW polysaccharide deacetylase FX998_23330 ENOG4108TUY outer membrane protein PgaA FX998_23335 ENOG4105BZU Histidine kinase FX998_23350 ENOG4108T85 Membrane FX998_23380 ENOG4107XHZ cytoplasmic chaperone TorD family protein FX998_23385 ENOG4108UQ5 membrane protein YcdZ FX998_23390 ENOG4105P8Q Curli production assembly transport component CsgG FX998_23395 ENOG4108WYR Curli production assembly transport component, CsgF FX998_23400 ENOG4108XDW curli assembly protein CsgE FX998_23405 ENOG41086KC Transcriptional regulator FX998_23410 ENOG4108U0V Curli are coiled surface structures that assemble preferentially at growth temperatures below 37 degrees Celsius. Curli can bind to fibronectin. The minor subunit is the nucleation component of curlin monomers FX998_23415 ENOG4105G76 Curli are coiled surface structures that assemble preferentially at growth temperatures below 37 degrees Celsius. Curli can bind to fibronectin FX998_23455 ENOG4105F5W AtP-binding protein FX998_23555 ENOG4105EKQ RNA-directed DNA polymerase FX998_23595 ENOG41073YN Protein of unknown function (DUF1380) FX998_23765 ENOG4107QJF Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity) FX998_23980 ENOG4107QHF type ii secretion system protein e FX998_23995 ENOG4105K5T PilT protein FX998_24075 ENOG4105CZX twitching motility protein FX998_24170 ENOG4105KF5 hemolysin expression-modulating protein FX998_24180 ENOG4105D7V transposase FX998_24425 ENOG41074AV Hok/gef family FX998_24485 ENOG410607W Transposase FX998_24525 ENOG41073YN Protein of unknown function (DUF1380) FX998_24635 ENOG4106CQM replication FX998_24650 ENOG4107AVE This protein is involved in the determination of copy number in gene replication. It binds to the repA promoter thus inhibiting the synthesis of the mRNA for the initiator protein repA (By similarity) FX998_24660 ENOG4105KF5 hemolysin expression-modulating protein FX998_24665 ENOG4105KK6 nuclease FX998_24675 ENOG4107CBI conjugal transfer fertility inhibition protein FX998_24695 ENOG4105I1F Resistance protein FX998_24750 ENOG4108YXQ IS66 Orf2 family protein FX998_24780 ENOG4107ENK receptor FX998_24815 ENOG4106JVB Replication Protein FX998_24855 ENOG4105DIK (ABC) transporter FX998_24860 ENOG4105CC5 ABC transporter FX998_24865 ENOG4105CC5 ABC transporter FX998_24885 ENOG41082CG Protein CrcB homolog FX998_24905 ENOG4105DUU IucA IucC family protein FX998_24910 ENOG4105F1Y L-lysine 6-monooxygenase (NADPH) FX998_24930 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) FX998_24935 ENOG4105M0J Toxic component of a toxin-antitoxin (TA) module. A FX998_24950 ENOG4105XY2 plasmid maintenance protein CcdA FX998_24955 ENOG4105PPN plasmid maintenance protein, CcdB FX998_24970 ENOG4105EZN Cobyrinic acid ac-diamide synthase FX998_24975 ENOG4106JGA Chromosome (Plasmid) partitioning protein, ParB FX998_25005 ENOG41073YN Protein of unknown function (DUF1380) FX998_25010 ENOG4106JQ7 FX998_25035 ENOG4107CBI conjugal transfer fertility inhibition protein FX998_25055 ENOG4108ZQS transposase FX998_25060 ENOG4108YXQ IS66 Orf2 family protein FX998_25065 ENOG4105E5H Transposase FX998_25115 ENOG4105CEU Arginine dihydrolase FX998_25120 ENOG4105C5B carbamate kinase FX998_25125 ENOG4105DBV ornithine carbamoyltransferase FX998_25130 ENOG4105CSX c4-dicarboxylate anaerobic carrier FX998_25150 ENOG4108YXQ IS66 Orf2 family protein FX998_25175 ENOG4105EQR Transposase IS116 IS110 IS902 FX998_25185 ENOG4107AVE This protein is involved in the determination of copy number in gene replication. It binds to the repA promoter thus inhibiting the synthesis of the mRNA for the initiator protein repA (By similarity) FX998_25200 ENOG4106CQM replication FX998_25250 ENOG4108KTG Membrane protein, drug metabolite transporter FX998_25320 ENOG4105EPC oxidoreductase FX998_25325 ENOG4108ZGB N-(5'-phosphoribosyl)anthranilate isomerase