locus-tag	class	description
I6K22_00010	COG1063	alcohol dehydrogenase
I6K22_00015	COG1802	Transcriptional regulator
I6K22_00025	COG0840	transmembrane signaling receptor activity
I6K22_00030	COG1966	Carbon starvation protein
I6K22_00035	COG2879	small protein
I6K22_00040	COG0523	cobalamin synthesis protein
I6K22_00065	COG2814	Major facilitator Superfamily
I6K22_00070	COG2733	membrane
I6K22_00075	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
I6K22_00080	COG1924	4 iron, 4 sulfur cluster binding
I6K22_00095	COG0477	Major facilitator Superfamily
I6K22_00105	COG3366	ferrous iron transmembrane transporter activity
I6K22_00110	COG0700	Nucleoside recognition
I6K22_00115	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
I6K22_00120	COG0583	DNA-binding transcription factor activity
I6K22_00145	COG2186	Transcriptional regulator
I6K22_00150	COG0246	Mannitol dehydrogenase
I6K22_00160	COG2610	gluconate transmembrane transporter activity
I6K22_00165	COG3539	Fimbrial protein
I6K22_00170	COG3539	Fimbrial protein
I6K22_00175	COG3539	Fimbrial protein
I6K22_00180	COG3188	usher protein
I6K22_00185	COG3121	Chaperone
I6K22_00190	COG3539	Fimbrial protein
I6K22_00200	COG4974	Belongs to the 'phage' integrase family
I6K22_00205	COG0582	viral genome integration into host DNA
I6K22_00210	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
I6K22_00215	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
I6K22_00240	COG3153	acetyltransferase
I6K22_00245	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
I6K22_00260	COG1363	Peptidase, m42
I6K22_00265	COG3414	Phosphotransferase system galactitol-specific IIB component
I6K22_00270	COG3775	system Galactitol-specific IIC component
I6K22_00275	COG0434	BtpA family
I6K22_00280	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K22_00285	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
I6K22_00290	COG1349	DNA-binding transcription factor activity
I6K22_00295	COG1414	Transcriptional regulator
I6K22_00300	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6K22_00305	COG0129	dihydroxy-acid dehydratase activity
I6K22_00310	COG2610	gluconate transmembrane transporter activity
I6K22_00315	COG2390	Transcriptional regulator
I6K22_00340	COG1215	transferase activity, transferring glycosyl groups
I6K22_00345	COG1401	restriction endodeoxyribonuclease activity
I6K22_00410	COG2003	Belongs to the UPF0758 family
I6K22_00435	COG3468	outer membrane autotransporter barrel domain protein
I6K22_00485	COG3436	PFAM IS66 Orf2 family protein
I6K22_00490	COG4372	Transposase
I6K22_00510	COG1349	DNA-binding transcription factor activity
I6K22_00520	COG0738	Major facilitator superfamily
I6K22_00535	COG3037	sugar-specific permease SgaT UlaA
I6K22_00545	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K22_00570	COG3010	Converts N-acetylmannosamine-6-phosphate (ManNAc-6-P) to N-acetylglucosamine-6-phosphate (GlcNAc-6-P)
I6K22_00575	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6K22_00575	COG2190	(PTS) system
I6K22_00575	COG1263	PTS System
I6K22_00580	COG1737	Transcriptional regulator
I6K22_00595	COG3177	Filamentation induced by cAMP protein fic
I6K22_00610	COG3335	DDE superfamily endonuclease
I6K22_00625	COG2205	protein histidine kinase activity
I6K22_00645	COG4227	nucleotidyltransferase activity
I6K22_00665	COG1064	alcohol dehydrogenase
I6K22_00670	COG3265	gluconokinase activity
I6K22_00675	COG1063	alcohol dehydrogenase
I6K22_00680	COG1028	Short-chain dehydrogenase reductase Sdr
I6K22_00685	COG2610	gluconate transmembrane transporter activity
I6K22_00690	COG1609	Transcriptional regulator
I6K22_00695	COG0433	COG0433 Predicted ATPase
I6K22_00700	COG0795	lipopolysaccharide-transporting ATPase activity
I6K22_00705	COG0795	lipopolysaccharide-transporting ATPase activity
I6K22_00715	COG2927	DNA polymerase III (CHI subunit)
I6K22_00720	COG0525	valine-tRNA ligase activity
I6K22_00730	COG0456	acetyltransferase
I6K22_00735	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
I6K22_00740	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
I6K22_00745	COG2731	YhcH YjgK YiaL family protein
I6K22_00755	COG0549	Belongs to the carbamate kinase family
I6K22_00760	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
I6K22_00765	COG1288	antiporter activity
I6K22_00770	COG1438	arginine binding
I6K22_00790	COG0251	oxidation-reduction process
I6K22_00795	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
I6K22_00805	COG1609	Transcriptional regulator
I6K22_00810	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6K22_00810	COG1263	PTS System
I6K22_00815	COG0366	Alpha amylase catalytic
I6K22_00820	COG1328	CTP reductase activity
I6K22_00825	COG0602	queuosine metabolic process
I6K22_00830	COG3783	Cytochrome b(562)
I6K22_00835	COG0312	modulator of DNA gyrase
I6K22_00845	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
I6K22_00855	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6K22_00860	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6K22_00865	COG1129	ABC transporter
I6K22_00870	COG1879	ABC-type sugar transport system periplasmic component
I6K22_00875	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
I6K22_00880	COG2105	PFAM AIG2 family protein
I6K22_00885	COG2911	Protein conserved in bacteria
I6K22_00890	COG0729	surface antigen
I6K22_00900	COG1253	flavin adenine dinucleotide binding
I6K22_00910	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
I6K22_00915	COG1218	3'(2'),5'-bisphosphate nucleotidase
I6K22_00920	COG0737	Belongs to the 5'-nucleotidase family
I6K22_00925	COG1733	regulation of RNA biosynthetic process
I6K22_00930	COG0702	epimerase
I6K22_00935	COG0697	spore germination
I6K22_00945	COG1113	amino acid transport
I6K22_00950	COG0545	Peptidyl-prolyl cis-trans isomerase
I6K22_00955	COG3061	Opacity-associated protein A
I6K22_00960	COG1309	transcriptional regulator
I6K22_00975	COG1024	Enoyl-CoA hydratase
I6K22_00980	COG4670	ketone body catabolic process
I6K22_00985	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
I6K22_00990	COG2271	Major facilitator Superfamily
I6K22_01010	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
I6K22_01050	COG3414	Phosphotransferase system galactitol-specific IIB component
I6K22_01055	COG3037	sugar-specific permease SgaT UlaA
I6K22_01070	COG1073	alpha beta
I6K22_01075	COG3650	response to hydrogen peroxide
I6K22_01085	COG1960	acyl-CoA dehydrogenase activity
I6K22_01090	COG0754	glutathionylspermidine amidase activity
I6K22_01095	COG5463	Belongs to the UPF0441 family
I6K22_01100	COG3766	membrane
I6K22_01110	COG1842	Phage shock protein A
I6K22_01115	COG3789	protein conserved in bacteria
I6K22_01120	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6K22_01125	COG0557	exoribonuclease II activity
I6K22_01140	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
I6K22_01145	COG0330	HflC and HflK could
I6K22_01150	COG0330	HflC and HflK could
I6K22_01155	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
I6K22_01175	COG0860	N-Acetylmuramoyl-L-alanine amidase
I6K22_01180	COG0802	atpase or kinase
I6K22_01185	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
I6K22_01185	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
I6K22_01190	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
I6K22_01230	COG1511	domain protein
I6K22_01230	COG3264	Mechanosensitive ion channel
I6K22_01245	COG0531	amino acid
I6K22_01255	COG1053	succinate dehydrogenase
I6K22_01260	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
I6K22_01275	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I6K22_01280	COG3040	lipid binding
I6K22_01285	COG2076	Multidrug Resistance protein
I6K22_01290	COG5510	response to toxic substance
I6K22_01295	COG5510	response to toxic substance
I6K22_01305	COG1509	lysine 2,3-aminomutase activity
I6K22_01330	COG0531	amino acid
I6K22_01335	COG3030	protein affecting phage T7 exclusion by the F plasmid
I6K22_01340	COG1027	Aspartate ammonia-lyase
I6K22_01345	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
I6K22_01360	COG1309	transcriptional regulator
I6K22_01370	COG0582	viral genome integration into host DNA
I6K22_01400	COG0531	amino acid
I6K22_01405	COG1982	Orn Lys Arg decarboxylase major
I6K22_01410	COG0531	amino acid
I6K22_01420	COG0604	alcohol dehydrogenase
I6K22_01475	COG2831	hemolysin activation secretion protein
I6K22_01500	COG4869	propanediol catabolic process
I6K22_01505	COG4820	ethanolamine utilization protein (EutJ)
I6K22_01540	COG1012	belongs to the aldehyde dehydrogenase family
I6K22_01550	COG0693	protein deglycase activity
I6K22_01555	COG1882	Formate acetyltransferase
I6K22_01560	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
I6K22_01580	COG2972	Histidine kinase
I6K22_01585	COG2207	Transcriptional regulator
I6K22_01590	COG0192	Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme
I6K22_01645	COG3596	GTP binding
I6K22_01650	COG2378	regulation of single-species biofilm formation
I6K22_01680	COG2003	Belongs to the UPF0758 family
I6K22_01715	COG3710	Transcriptional regulator
I6K22_01720	COG0531	amino acid
I6K22_01725	COG1982	Orn Lys Arg decarboxylase major
I6K22_01730	COG3104	oligopeptide transport
I6K22_01735	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
I6K22_01750	COG2388	GCN5-related N-acetyl-transferase
I6K22_01755	COG3592	Divergent 4Fe-4S mono-cluster
I6K22_01760	COG3290	protein histidine kinase activity
I6K22_01765	COG4565	transcriptional regulatory protein
I6K22_01770	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
I6K22_01775	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
I6K22_01775	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
I6K22_01780	COG3647	Membrane
I6K22_01785	COG1486	melibiose metabolic process
I6K22_01790	COG2169	Transcriptional regulator
I6K22_01795	COG1982	Orn Lys Arg decarboxylase major
I6K22_01800	COG2207	Transcriptional regulator
I6K22_01805	COG0531	amino acid
I6K22_01810	COG2194	sulfuric ester hydrolase activity
I6K22_01815	COG0745	RESPONSE REGULATOR receiver
I6K22_01820	COG0642	Histidine kinase
I6K22_01830	COG0477	Major facilitator Superfamily
I6K22_01845	COG2824	Alkylphosphonate utilization operon protein PhnA
I6K22_01850	COG2764	glyoxalase bleomycin resistance protein dioxygenase
I6K22_01860	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
I6K22_01865	COG3639	organic phosphonate transmembrane transporter activity
I6K22_01870	COG2188	Transcriptional regulator
I6K22_01875	COG3624	Phosphonate C-P lyase system protein PhnG
I6K22_01880	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
I6K22_01885	COG3626	phosphonate metabolism
I6K22_01890	COG3627	carbon phosphorus lyase activity
I6K22_01895	COG4107	phosphonate C-P lyase system protein PhnK
I6K22_01900	COG4778	phosphonate C-P lyase system protein PhnL
I6K22_01905	COG3454	Phosphonate metabolism
I6K22_01915	COG0456	acetyltransferase
I6K22_01920	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
I6K22_01930	COG0698	ribose 5-phosphate isomerase
I6K22_01935	COG1737	Transcriptional regulator
I6K22_01940	COG1879	ABC-type sugar transport system periplasmic component
I6K22_01945	COG1129	ABC transporter
I6K22_01955	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
I6K22_01960	COG1940	carbohydrate kinase activity
I6K22_01965	COG2015	COG2015, Alkyl sulfatase and related hydrolases
I6K22_01975	COG1566	PFAM secretion protein HlyD family protein
I6K22_01980	COG1289	transmembrane transporter activity
I6K22_02000	COG0601	transmembrane transport
I6K22_02005	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6K22_02010	COG0444	Belongs to the ABC transporter superfamily
I6K22_02015	COG4608	Belongs to the ABC transporter superfamily
I6K22_02020	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
I6K22_02025	COG1301	dicarboxylic acid transport
I6K22_02030	COG4235	cytochrome complex assembly
I6K22_02035	COG3088	subunit of a heme lyase
I6K22_02040	COG1138	Cytochrome C-type biogenesis protein
I6K22_02045	COG3301	Polysulphide reductase, NrfD
I6K22_02050	COG0437	4 iron, 4 sulfur cluster binding
I6K22_02055	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
I6K22_02065	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I6K22_02070	COG3162	membrane
I6K22_02080	COG1346	cytolysis
I6K22_02085	COG1380	Effector of murein hydrolase LrgA
I6K22_02090	COG0583	DNA-binding transcription factor activity
I6K22_02095	COG0025	NhaP-type Na H and K H
I6K22_02100	COG2252	PERMEase
I6K22_02105	COG0789	Transcriptional regulator
I6K22_02110	COG2207	Transcriptional regulator
I6K22_02115	COG4943	cyclic-guanylate-specific phosphodiesterase activity
I6K22_02125	COG0629	single-stranded DNA binding
I6K22_02130	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
I6K22_02135	COG2315	Protein conserved in bacteria
I6K22_02140	COG0432	Pfam Uncharacterised protein family UPF0047
I6K22_02145	COG3700	Belongs to the class B bacterial acid phosphatase family
I6K22_02155	COG2204	response regulator
I6K22_02160	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
I6K22_02165	COG0471	metal ion transport
I6K22_02170	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
I6K22_02175	COG0045	succinate-CoA ligase (ADP-forming) activity
I6K22_02180	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6K22_02190	COG0567	Dehydrogenase, E1 component
I6K22_02195	COG1448	Aminotransferase
I6K22_02205	COG3201	nicotinamide mononucleotide transporter
I6K22_02210	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
I6K22_02215	COG0305	Participates in initiation and elongation during chromosome replication
I6K22_02220	COG1609	Transcriptional regulator
I6K22_02230	COG1024	Enoyl-CoA hydratase
I6K22_02235	COG0477	Major facilitator Superfamily
I6K22_02240	COG1053	succinate dehydrogenase
I6K22_02245	COG0604	alcohol dehydrogenase
I6K22_02255	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I6K22_02285	COG5301	cellulose 1,4-beta-cellobiosidase activity
I6K22_02360	COG0740	serine-type endopeptidase activity
I6K22_02395	COG3772	lysozyme
I6K22_02425	COG1403	HNH endonuclease
I6K22_02435	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
I6K22_02445	COG4725	Belongs to the MT-A70-like family
I6K22_02455	COG1846	Transcriptional regulator
I6K22_02465	COG3646	Phage regulatory protein
I6K22_02490	COG5532	Uncharacterized conserved protein (DUF2303)
I6K22_02495	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
I6K22_02545	COG0735	belongs to the Fur family
I6K22_02550	COG3237	CsbD-like
I6K22_02555	COG0534	Mate efflux family protein
I6K22_02565	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
I6K22_02595	COG3842	ATPase activity
I6K22_02600	COG2182	Extracellular solute-binding protein
I6K22_02605	COG1175	transmembrane transport
I6K22_02610	COG3833	ABC-type maltose transport systems, permease component
I6K22_02625	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6K22_02650	COG0527	aspartate kinase activity
I6K22_02660	COG1187	pseudouridine synthase activity
I6K22_02705	COG1283	sodium-dependent phosphate transmembrane transporter activity
I6K22_02720	COG1410	methionine synthase
I6K22_02720	COG0646	methionine synthase
I6K22_02725	COG1414	Transcriptional regulator
I6K22_02735	COG2224	Isocitrate lyase
I6K22_02740	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
I6K22_02750	COG0456	acetyltransferase
I6K22_02785	COG0151	Belongs to the GarS family
I6K22_02790	COG2204	response regulator
I6K22_02795	COG4191	Histidine kinase
I6K22_02800	COG3678	ATP-independent chaperone mediated protein folding
I6K22_02815	COG3068	Protein conserved in bacteria
I6K22_02850	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
I6K22_02855	COG2104	thiamine diphosphate biosynthetic process
I6K22_02865	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
I6K22_02900	COG0250	Participates in transcription elongation, termination and antitermination
I6K22_02905	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
I6K22_02940	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
I6K22_02940	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
I6K22_02945	COG0812	UDP-N-acetylmuramate dehydrogenase activity
I6K22_02995	COG0477	Major facilitator Superfamily
I6K22_03000	COG1473	amidohydrolase
I6K22_03010	COG0583	DNA-binding transcription factor activity
I6K22_03015	COG2271	Major facilitator Superfamily
I6K22_03020	COG4948	Mandelate Racemase Muconate Lactonizing
I6K22_03035	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
I6K22_03050	COG2194	sulfuric ester hydrolase activity
I6K22_03055	COG2207	Transcriptional regulator
I6K22_03060	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6K22_03065	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
I6K22_03070	COG1882	Formate acetyltransferase
I6K22_03075	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6K22_03080	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6K22_03085	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I6K22_03085	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K22_03085	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K22_03090	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
I6K22_03095	COG0371	Dehydrogenase
I6K22_03100	COG3738	Protein conserved in bacteria
I6K22_03105	COG0697	spore germination
I6K22_03115	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
I6K22_03120	COG0737	Belongs to the 5'-nucleotidase family
I6K22_03130	COG0737	Belongs to the 5'-nucleotidase family
I6K22_03135	COG0737	Belongs to the 5'-nucleotidase family
I6K22_03145	COG0527	aspartate kinase activity
I6K22_03145	COG0460	homoserine dehydrogenase
I6K22_03150	COG0626	cystathionine gamma-synthase activity
I6K22_03160	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
I6K22_03170	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
I6K22_03175	COG1609	Transcriptional regulator
I6K22_03180	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
I6K22_03195	COG1575	Belongs to the MenA family. Type 1 subfamily
I6K22_03210	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
I6K22_03220	COG1494	fructose-1,6-bisphosphatase
I6K22_03230	COG0589	response to stress
I6K22_03235	COG3691	Protein conserved in bacteria
I6K22_03240	COG3152	Membrane
I6K22_03260	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
I6K22_03275	COG3678	ATP-independent chaperone mediated protein folding
I6K22_03280	COG0745	RESPONSE REGULATOR receiver
I6K22_03285	COG2205	protein histidine kinase activity
I6K22_03290	COG2258	MOSC domain
I6K22_03300	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
I6K22_03360	COG0437	4 iron, 4 sulfur cluster binding
I6K22_03365	COG2864	formate dehydrogenase
I6K22_03390	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
I6K22_03400	COG0456	acetyltransferase
I6K22_03415	COG1011	Hydrolase
I6K22_03425	COG0477	Major facilitator Superfamily
I6K22_03435	COG1063	alcohol dehydrogenase
I6K22_03440	COG3684	Belongs to the aldolase LacD family
I6K22_03445	COG2084	Dehydrogenase
I6K22_03450	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6K22_03455	COG1349	DNA-binding transcription factor activity
I6K22_03460	COG1217	gtp-binding protein TYPA
I6K22_03465	COG0174	glutamine synthetase
I6K22_03470	COG3852	Histidine kinase
I6K22_03475	COG2204	response regulator
I6K22_03485	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I6K22_03500	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I6K22_03500	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I6K22_03505	COG0204	Acyl-transferase
I6K22_03510	COG5339	Protein conserved in bacteria
I6K22_03515	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I6K22_03520	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
I6K22_03525	COG3084	Protein conserved in bacteria
I6K22_03530	COG0746	molybdenum cofactor guanylyltransferase activity
I6K22_03535	COG1763	Mo-molybdopterin cofactor biosynthetic process
I6K22_03565	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
I6K22_03570	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
I6K22_03575	COG1739	Uncharacterized protein family UPF0029
I6K22_03595	COG0543	2 iron, 2 sulfur cluster binding
I6K22_03600	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
I6K22_03615	COG0805	protein transport
I6K22_03625	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I6K22_03635	COG3165	ubiquinone biosynthetic process from chorismate
I6K22_03645	COG1322	Protein conserved in bacteria
I6K22_03650	COG1414	Transcriptional regulator
I6K22_03655	COG3734	2-keto-3-deoxy-galactonokinase
I6K22_03660	COG0800	Aldolase
I6K22_03680	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
I6K22_03685	COG0412	Dienelactone hydrolase
I6K22_03690	COG1335	isochorismatase
I6K22_03700	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
I6K22_03705	COG1304	FMN binding
I6K22_03710	COG0549	Belongs to the carbamate kinase family
I6K22_03720	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
I6K22_03725	COG0583	DNA-binding transcription factor activity
I6K22_03730	COG1737	Transcriptional regulator
I6K22_03735	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
I6K22_03740	COG2190	(PTS) system
I6K22_03740	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6K22_03740	COG1263	PTS System
I6K22_03750	COG3157	Type VI secretion system effector, Hcp
I6K22_03770	COG0583	DNA-binding transcription factor activity
I6K22_03775	COG0697	spore germination
I6K22_03780	COG0561	phosphatase activity
I6K22_03785	COG2267	carboxylic ester hydrolase activity
I6K22_03790	COG1280	lysine exporter protein (LysE YggA)
I6K22_03795	COG1280	lysine exporter protein (LysE YggA)
I6K22_03800	COG0514	ATP-dependent DNA helicase (RecQ)
I6K22_03805	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
I6K22_03810	COG2050	protein possibly involved in aromatic compounds catabolism
I6K22_03815	COG2962	Rard protein
I6K22_03830	COG0598	Magnesium transport protein CorA
I6K22_03835	COG3698	Phosphodiester glycosidase
I6K22_03840	COG1912	Pfam S-adenosyl-l-methionine hydroxide adenosyltransferase
I6K22_03845	COG0210	DNA helicase
I6K22_03850	COG1011	Hydrolase
I6K22_03860	COG3159	Protein conserved in bacteria
I6K22_03870	COG5567	small periplasmic lipoprotein
I6K22_03890	COG3072	Adenylate cyclase
I6K22_03900	COG1587	Uroporphyrinogen-III synthase
I6K22_03905	COG2959	enzyme of heme biosynthesis
I6K22_03910	COG3071	HemY protein
I6K22_03915	COG3119	arylsulfatase activity
I6K22_03920	COG0641	radical SAM
I6K22_03945	COG1113	amino acid transport
I6K22_03965	COG2244	polysaccharide biosynthetic process
I6K22_03970	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
I6K22_03975	COG0456	acetyltransferase
I6K22_03980	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
I6K22_03985	COG1088	dTDP-glucose 4,6-dehydratase activity
I6K22_03990	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
I6K22_03995	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
I6K22_04000	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
I6K22_04005	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I6K22_04010	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
I6K22_04020	COG3118	belongs to the thioredoxin family
I6K22_04035	COG0210	DNA helicase
I6K22_04040	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6K22_04050	COG0583	DNA-binding transcription factor activity
I6K22_04055	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I6K22_04065	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I6K22_04070	COG3978	acetolactate synthase activity
I6K22_04090	COG0606	chelatase, subunit chli
I6K22_04095	COG3085	chromosome segregation
I6K22_04135	COG2186	Transcriptional regulator
I6K22_04140	COG0477	Major facilitator Superfamily
I6K22_04145	COG1609	Transcriptional regulator
I6K22_04150	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6K22_04155	COG1879	ABC-type sugar transport system periplasmic component
I6K22_04160	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6K22_04195	COG1522	sequence-specific DNA binding
I6K22_04200	COG0716	FMN binding
I6K22_04215	COG3312	ion transport
I6K22_04270	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
I6K22_04275	COG0573	inorganic phosphate transmembrane transporter activity
I6K22_04280	COG0581	inorganic phosphate transmembrane transporter activity
I6K22_04285	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
I6K22_04290	COG0704	Plays a role in the regulation of phosphate uptake
I6K22_04295	COG3711	transcriptional antiterminator
I6K22_04300	COG1263	PTS System
I6K22_04300	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6K22_04300	COG2190	(PTS) system
I6K22_04305	COG2723	6-phospho-beta-galactosidase activity
I6K22_04315	COG2382	esterase
I6K22_04320	COG0363	glucosamine-6-phosphate deaminase activity
I6K22_04335	COG2252	PERMEase
I6K22_04340	COG0431	NADPH-dependent FMN reductase
I6K22_04345	COG2091	lysine biosynthetic process via aminoadipic acid
I6K22_04350	COG0583	DNA-binding transcription factor activity
I6K22_04360	COG0814	amino acid
I6K22_04410	COG0592	DNA-directed DNA polymerase activity
I6K22_04420	COG0187	DNA topoisomerase II activity
I6K22_04425	COG3753	Protein conserved in bacteria
I6K22_04430	COG0561	phosphatase activity
I6K22_04440	COG2186	Transcriptional regulator
I6K22_04445	COG3734	2-keto-3-deoxy-galactonokinase
I6K22_04450	COG0800	Aldolase
I6K22_04460	COG2271	Major facilitator Superfamily
I6K22_04470	COG0823	Involved in the tonB-independent uptake of proteins
I6K22_04475	COG5645	(Lipo)protein
I6K22_04495	COG2207	Transcriptional regulator
I6K22_04500	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6K22_04510	COG2149	membrane
I6K22_04520	COG0641	radical SAM
I6K22_04525	COG2814	Major facilitator Superfamily
I6K22_04535	COG0028	Belongs to the TPP enzyme family
I6K22_04540	COG0440	acetolactate synthase activity
I6K22_04545	COG2197	response regulator
I6K22_04550	COG3851	Histidine kinase
I6K22_04555	COG2271	Major facilitator Superfamily
I6K22_04560	COG2271	Major facilitator Superfamily
I6K22_04570	COG2252	PERMEase
I6K22_04590	COG1464	Belongs to the NlpA lipoprotein family
I6K22_04595	COG0697	spore germination
I6K22_04615	COG2211	Major facilitator Superfamily
I6K22_04620	COG1501	Belongs to the glycosyl hydrolase 31 family
I6K22_04625	COG3711	transcriptional antiterminator
I6K22_04630	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K22_04630	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6K22_04630	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6K22_04635	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6K22_04640	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6K22_04640	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6K22_04655	COG1940	carbohydrate kinase activity
I6K22_04665	COG2982	Protein involved in outer membrane biogenesis
I6K22_04670	COG2233	PERMEase
I6K22_04675	COG0786	glutamate:sodium symporter activity
I6K22_04680	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
I6K22_04685	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6K22_04690	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I6K22_04700	COG0194	GDP metabolic process
I6K22_04710	COG2860	membrane
I6K22_04715	COG3645	SOS response
I6K22_04835	COG1561	YicC-like family, N-terminal region
I6K22_04860	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
I6K22_04890	COG1519	Transferase
I6K22_04895	COG0859	PFAM glycosyl transferase family 9
I6K22_04900	COG0438	transferase activity, transferring glycosyl groups
I6K22_04905	COG0515	serine threonine protein kinase
I6K22_04920	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
I6K22_04925	COG1442	glycosyl transferase family 8
I6K22_04930	COG1216	Glycosyl transferase, family 2
I6K22_04935	COG3307	-O-antigen
I6K22_04940	COG0859	PFAM glycosyl transferase family 9
I6K22_04945	COG0859	PFAM glycosyl transferase family 9
I6K22_04955	COG0156	8-amino-7-oxononanoate synthase activity
I6K22_04965	COG1216	Glycosyl transferase, family 2
I6K22_04970	COG2861	carbohydrate metabolic process
I6K22_04975	COG4942	peptidase
I6K22_04985	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I6K22_04990	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
I6K22_05005	COG1045	serine acetyltransferase
I6K22_05010	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
I6K22_05020	COG2186	Transcriptional regulator
I6K22_05025	COG1620	l-lactate permease
I6K22_05030	COG5295	Hep Hag repeat protein
I6K22_05050	COG3722	fumarate hydratase activity
I6K22_05060	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K22_05060	COG2213	PTS system mannitol-specific
I6K22_05070	COG1566	PFAM secretion protein HlyD family protein
I6K22_05075	COG0625	glutathione transferase activity
I6K22_05085	COG3276	selenocysteine insertion sequence binding
I6K22_05090	COG1454	alcohol dehydrogenase
I6K22_05100	COG1012	belongs to the aldehyde dehydrogenase family
I6K22_05105	COG0235	Class ii aldolase
I6K22_05110	COG3623	hexulose-6-phosphate isomerase
I6K22_05115	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
I6K22_05120	COG1070	Carbohydrate kinase
I6K22_05125	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
I6K22_05130	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
I6K22_05135	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
I6K22_05145	COG2731	YhcH YjgK YiaL family protein
I6K22_05155	COG1414	Transcriptional regulator
I6K22_05160	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6K22_05165	COG3977	Valine--pyruvate aminotransferase
I6K22_05170	COG0366	Alpha amylase catalytic
I6K22_05175	COG2992	FlgJ-related protein
I6K22_05180	COG1609	Transcriptional regulator
I6K22_05180	COG2207	Transcriptional regulator
I6K22_05185	COG4214	carbohydrate transport
I6K22_05195	COG4213	ABC transporter substrate-binding protein
I6K22_05205	COG1070	Carbohydrate kinase
I6K22_05210	COG4682	membrane
I6K22_05215	COG4682	membrane
I6K22_05220	COG3274	enterobacterial common antigen metabolic process
I6K22_05245	COG1278	Cold shock
I6K22_05250	COG2944	sequence-specific DNA binding
I6K22_05265	COG2885	chlorophyll binding
I6K22_05270	COG0243	molybdopterin cofactor binding
I6K22_05275	COG0456	acetyltransferase
I6K22_05280	COG2818	Glycosylase
I6K22_05285	COG5571	outer membrane autotransporter
I6K22_05290	COG2223	nitrite transmembrane transporter activity
I6K22_05295	COG2194	sulfuric ester hydrolase activity
I6K22_05305	COG0747	negative chemotaxis
I6K22_05310	COG0601	transmembrane transport
I6K22_05315	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6K22_05320	COG0444	Belongs to the ABC transporter superfamily
I6K22_05325	COG4608	Belongs to the ABC transporter superfamily
I6K22_05330	COG0814	amino acid
I6K22_05355	COG1215	transferase activity, transferring glycosyl groups
I6K22_05360	COG1215	transferase activity, transferring glycosyl groups
I6K22_05365	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
I6K22_05370	COG3118	belongs to the thioredoxin family
I6K22_05370	COG0457	Tetratricopeptide repeat
I6K22_05375	COG2200	EAL domain
I6K22_05375	COG2199	diguanylate cyclase activity
I6K22_05385	COG0612	Peptidase, M16
I6K22_05390	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6K22_05395	COG2200	EAL domain
I6K22_05400	COG2982	Protein involved in outer membrane biogenesis
I6K22_05405	COG0477	Major facilitator Superfamily
I6K22_05410	COG1295	ribonuclease BN
I6K22_05415	COG0583	DNA-binding transcription factor activity
I6K22_05420	COG2197	response regulator
I6K22_05430	COG1858	cytochrome C peroxidase
I6K22_05435	COG0076	glutamate decarboxylase activity
I6K22_05440	COG2207	Transcriptional regulator
I6K22_05445	COG2207	Transcriptional regulator
I6K22_05450	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6K22_05455	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6K22_05465	COG2771	luxR family
I6K22_05470	COG3247	response to pH
I6K22_05485	COG1285	pathogenesis
I6K22_05495	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6K22_05505	COG3721	Heme iron utilization protein
I6K22_05520	COG4771	TonB-dependent receptor
I6K22_05525	COG3720	iron ion transport
I6K22_05530	COG2197	response regulator
I6K22_05535	COG3065	identical protein binding
I6K22_05545	COG1393	Belongs to the ArsC family
I6K22_05555	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6K22_05560	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
I6K22_05565	COG0339	signal peptide processing
I6K22_05575	COG3104	oligopeptide transport
I6K22_05580	COG0589	response to stress
I6K22_05590	COG0306	phosphate transporter
I6K22_05595	COG2081	HI0933 family
I6K22_05605	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6K22_05610	COG1129	ABC transporter
I6K22_05610	COG0842	Transport permease protein
I6K22_05615	COG0842	Transport permease protein
I6K22_05620	COG0191	fructose-bisphosphate aldolase activity
I6K22_05635	COG3775	system Galactitol-specific IIC component
I6K22_05640	COG3414	Phosphotransferase system galactitol-specific IIB component
I6K22_05650	COG2188	Transcriptional regulator
I6K22_05670	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6K22_05675	COG0601	transmembrane transport
I6K22_05680	COG0747	negative chemotaxis
I6K22_05685	COG2091	lysine biosynthetic process via aminoadipic acid
I6K22_05690	COG0628	permease
I6K22_05695	COG0477	Major facilitator Superfamily
I6K22_05705	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
I6K22_05720	COG3714	YhhN family
I6K22_05730	COG3776	membrane
I6K22_05735	COG0742	ribosomal rna small subunit methyltransferase
I6K22_05740	COG0552	protein localization to endoplasmic reticulum
I6K22_05745	COG2884	Cell division ATP-binding protein ftsE
I6K22_05750	COG2177	Part of the ABC transporter FtsEX involved in
I6K22_05755	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I6K22_05760	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6K22_05765	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I6K22_05790	COG0683	leucine binding
I6K22_05795	COG0456	acetyltransferase
I6K22_05800	COG0683	leucine binding
I6K22_05805	COG0559	Belongs to the binding-protein-dependent transport system permease family
I6K22_05810	COG4177	L-phenylalanine transmembrane transporter activity
I6K22_05815	COG0411	ABC transporter
I6K22_05820	COG0410	ABC transporter
I6K22_05845	COG0584	glycerophosphoryl diester phosphodiesterase
I6K22_05855	COG0405	Gamma-glutamyltransferase
I6K22_05880	COG1247	-acetyltransferase
I6K22_05885	COG0673	inositol 2-dehydrogenase activity
I6K22_05890	COG1741	Belongs to the pirin family
I6K22_05895	COG1609	Transcriptional regulator
I6K22_05900	COG3265	gluconokinase activity
I6K22_05905	COG2610	gluconate transmembrane transporter activity
I6K22_05910	COG2095	MarC family integral membrane protein
I6K22_05915	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
I6K22_05940	COG0058	SHG alpha-glucan phosphorylase activity
I6K22_05950	COG3121	Chaperone
I6K22_05955	COG3188	usher protein
I6K22_05995	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
I6K22_06010	COG1349	DNA-binding transcription factor activity
I6K22_06015	COG4650	regulator
I6K22_06020	COG1690	Belongs to the RtcB family
I6K22_06035	COG0058	SHG alpha-glucan phosphorylase activity
I6K22_06040	COG1640	4-alpha-glucanotransferase
I6K22_06045	COG2610	gluconate transmembrane transporter activity
I6K22_06055	COG1040	competence protein
I6K22_06065	COG5464	transposase or invertase
I6K22_06075	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
I6K22_06080	COG1918	ferrous iron import across plasma membrane
I6K22_06085	COG2183	response to ionizing radiation
I6K22_06090	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I6K22_06110	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
I6K22_06120	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
I6K22_06125	COG1011	Hydrolase
I6K22_06135	COG0494	nUDIX hydrolase
I6K22_06140	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
I6K22_06145	COG4972	Pilus assembly protein
I6K22_06150	COG3166	PFAM Fimbrial assembly family protein
I6K22_06165	COG4796	Type ii and iii secretion system protein
I6K22_06180	COG3266	domain, Protein
I6K22_06185	COG0338	D12 class N6 adenine-specific DNA methyltransferase
I6K22_06190	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
I6K22_06195	COG0546	phosphoglycolate phosphatase activity
I6K22_06200	COG0180	Tryptophanyl-tRNA synthetase
I6K22_06205	COG2188	Transcriptional regulator
I6K22_06215	COG3457	Alanine racemase
I6K22_06220	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
I6K22_06225	COG1735	metal-dependent hydrolase with the TIM-barrel fold
I6K22_06240	COG0626	cystathionine gamma-synthase activity
I6K22_06255	COG2116	formate transmembrane transporter activity
I6K22_06260	COG2146	nitrite reductase [NAD(P)H] activity
I6K22_06265	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I6K22_06275	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
I6K22_06285	COG2184	nucleotidyltransferase activity
I6K22_06290	COG0512	Glutamine amidotransferase of anthranilate synthase
I6K22_06295	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I6K22_06300	COG1289	transmembrane transporter activity
I6K22_06305	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I6K22_06310	COG1765	OsmC-like protein
I6K22_06315	COG3954	Phosphoribulokinase
I6K22_06325	COG0429	hydrolase of the alpha beta-hydrolase fold
I6K22_06330	COG0488	(ABC) transporter
I6K22_06345	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
I6K22_06350	COG1047	Peptidyl-prolyl cis-trans
I6K22_06360	COG0545	Peptidyl-prolyl cis-trans isomerase
I6K22_06365	COG2964	Protein conserved in bacteria
I6K22_06405	COG3979	chitinase
I6K22_06410	COG2906	2 iron, 2 sulfur cluster binding
I6K22_06415	COG2193	ferroxidase activity
I6K22_06420	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
I6K22_06425	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
I6K22_06430	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
I6K22_06435	COG3156	type II secretion system protein K
I6K22_06440	COG4795	General secretion pathway protein
I6K22_06445	COG2165	general secretion pathway protein
I6K22_06450	COG2165	general secretion pathway protein
I6K22_06455	COG2165	general secretion pathway protein
I6K22_06460	COG1459	type II secretion system
I6K22_06465	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I6K22_06470	COG1450	Type ii and iii secretion system protein
I6K22_06475	COG3031	protein transport across the cell outer membrane
I6K22_06480	COG3267	Type II secretory pathway component ExeA
I6K22_06480	COG3409	Peptidoglycan-binding domain 1 protein
I6K22_06505	COG0089	rRNA binding
I6K22_06595	COG0201	protein transport
I6K22_06635	COG0789	Transcriptional regulator
I6K22_06640	COG3036	rescue of stalled ribosome
I6K22_06650	COG0569	domain protein
I6K22_06670	COG0758	DNA mediated transformation
I6K22_06680	COG0551	DNA topoisomerase type I activity
I6K22_06700	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
I6K22_06740	COG1126	abc transporter atp-binding protein
I6K22_06745	COG0765	amino acid transport
I6K22_06750	COG4597	amino acid ABC transporter
I6K22_06755	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6K22_06765	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6K22_06770	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6K22_06775	COG1309	transcriptional regulator
I6K22_06785	COG2189	Belongs to the N(4) N(6)-methyltransferase family
I6K22_06795	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I6K22_06805	COG4145	pantothenate transmembrane transporter activity
I6K22_06810	COG3924	membrane
I6K22_06815	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6K22_06820	COG1349	DNA-binding transcription factor activity
I6K22_06830	COG1879	ABC-type sugar transport system periplasmic component
I6K22_06835	COG1129	ABC transporter
I6K22_06840	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6K22_06845	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6K22_06855	COG0439	Biotin carboxylase
I6K22_06860	COG0511	ligase activity, forming carbon-carbon bonds
I6K22_06865	COG0604	alcohol dehydrogenase
I6K22_06870	COG2200	EAL domain
I6K22_06870	COG2199	diguanylate cyclase activity
I6K22_06875	COG1077	Cell shape determining protein MreB Mrl
I6K22_06880	COG1792	Involved in formation and maintenance of cell shape
I6K22_06885	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
I6K22_06895	COG1530	ribonuclease E activity
I6K22_06900	COG3164	Protein of unknown function
I6K22_06905	COG0312	modulator of DNA gyrase
I6K22_06910	COG0583	DNA-binding transcription factor activity
I6K22_06930	COG2732	(Barnase) inhibitor
I6K22_06950	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6K22_06955	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6K22_06960	COG3105	Protein conserved in bacteria
I6K22_06965	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
I6K22_06980	COG0625	glutathione transferase activity
I6K22_06985	COG2969	positive regulation of protein catabolic process
I6K22_07015	COG2731	YhcH YjgK YiaL family protein
I6K22_07020	COG0493	'glutamate synthase
I6K22_07025	COG0070	glutamate synthase
I6K22_07025	COG0069	glutamate synthase activity
I6K22_07025	COG0067	glutamate synthase
I6K22_07030	COG1242	4 iron, 4 sulfur cluster binding
I6K22_07035	COG0784	Response regulator, receiver
I6K22_07035	COG2198	Histidine kinase
I6K22_07035	COG5002	protein histidine kinase activity
I6K22_07040	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
I6K22_07050	COG0515	serine threonine protein kinase
I6K22_07055	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K22_07070	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
I6K22_07075	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
I6K22_07080	COG1137	ATPase activity
I6K22_07085	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
I6K22_07090	COG3117	lipopolysaccharide transmembrane transporter activity
I6K22_07095	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
I6K22_07100	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
I6K22_07100	COG0517	IMP dehydrogenase activity
I6K22_07105	COG0530	calcium, potassium:sodium antiporter activity
I6K22_07110	COG1127	ABC transporter
I6K22_07115	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
I6K22_07120	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
I6K22_07125	COG2854	intermembrane phospholipid transfer
I6K22_07130	COG3113	response to antibiotic
I6K22_07135	COG5007	Belongs to the BolA IbaG family
I6K22_07145	COG3423	Transcriptional regulator
I6K22_07150	COG0142	geranyltranstransferase activity
I6K22_07165	COG0697	spore germination
I6K22_07175	COG2027	D-alanyl-D-alanine carboxypeptidase
I6K22_07180	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I6K22_07185	COG1534	Rna-binding protein
I6K22_07195	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I6K22_07200	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
I6K22_07210	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
I6K22_07220	COG2194	sulfuric ester hydrolase activity
I6K22_07240	COG0195	Participates in both transcription termination and antitermination
I6K22_07280	COG0513	Belongs to the DEAD box helicase family
I6K22_07285	COG0814	amino acid
I6K22_07290	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6K22_07295	COG0826	peptidase U32
I6K22_07300	COG0826	peptidase U32
I6K22_07305	COG3154	lipid carrier protein
I6K22_07310	COG3153	acetyltransferase
I6K22_07325	COG0693	protein deglycase activity
I6K22_07330	COG0702	epimerase
I6K22_07335	COG0701	Predicted permease
I6K22_07340	COG2823	Periplasmic or secreted lipoprotein
I6K22_07355	COG3107	peptidoglycan biosynthetic process
I6K22_07360	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
I6K22_07365	COG0363	glucosamine-6-phosphate deaminase activity
I6K22_07370	COG3716	PTS system mannose fructose sorbose family IID component
I6K22_07375	COG3715	PTS system
I6K22_07380	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6K22_07390	COG2222	sugar isomerase
I6K22_07395	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
I6K22_07400	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K22_07405	COG3716	PTS system mannose fructose sorbose family IID component
I6K22_07415	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6K22_07425	COG1349	DNA-binding transcription factor activity
I6K22_07430	COG2721	sulfolactate sulfo-lyase activity
I6K22_07435	COG2271	Major facilitator Superfamily
I6K22_07445	COG2084	Dehydrogenase
I6K22_07450	COG1929	Belongs to the glycerate kinase type-1 family
I6K22_07465	COG0583	DNA-binding transcription factor activity
I6K22_07470	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I6K22_07480	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
I6K22_07485	COG1882	Formate acetyltransferase
I6K22_07490	COG0251	oxidation-reduction process
I6K22_07495	COG1760	l-serine dehydratase
I6K22_07500	COG0814	amino acid
I6K22_07515	COG1741	Belongs to the pirin family
I6K22_07520	COG0583	DNA-binding transcription factor activity
I6K22_07525	COG3152	Membrane
I6K22_07530	COG0435	Glutathione S-transferase
I6K22_07535	COG2259	Doxx family
I6K22_07545	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
I6K22_07550	COG4575	ribosome binding
I6K22_07555	COG1422	Protein of unknown function (DUF1090)
I6K22_07565	COG0586	Pfam SNARE associated Golgi protein
I6K22_07570	COG2186	Transcriptional regulator
I6K22_07575	COG2271	Major facilitator Superfamily
I6K22_07585	COG2721	sulfolactate sulfo-lyase activity
I6K22_07600	COG0861	Integral membrane protein TerC family
I6K22_07605	COG0673	inositol 2-dehydrogenase activity
I6K22_07610	COG2949	membrane
I6K22_07615	COG1451	nucleotide metabolic process
I6K22_07625	COG0446	pyridine nucleotide-disulphide oxidoreductase
I6K22_07625	COG1902	pentaerythritol trinitrate reductase activity
I6K22_07630	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
I6K22_07630	COG3408	Glycogen debranching enzyme
I6K22_07640	COG0531	amino acid
I6K22_07645	COG2731	YhcH YjgK YiaL family protein
I6K22_07650	COG3250	beta-galactosidase activity
I6K22_07655	COG1609	Transcriptional regulator
I6K22_07660	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
I6K22_07670	COG0840	transmembrane signaling receptor activity
I6K22_07675	COG1695	Transcriptional regulator
I6K22_07680	COG2375	cellular response to nickel ion
I6K22_07695	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I6K22_07700	COG0358	DNA primase activity
I6K22_07705	COG0828	Belongs to the bacterial ribosomal protein bS21 family
I6K22_07720	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
I6K22_07740	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
I6K22_07755	COG4991	sh3 domain protein
I6K22_07760	COG3025	triphosphatase activity
I6K22_07780	COG2268	Band 7 protein
I6K22_07785	COG1585	Membrane protein implicated in regulation of membrane protease activity
I6K22_07805	COG3539	Fimbrial protein
I6K22_07810	COG3121	Chaperone
I6K22_07815	COG3188	usher protein
I6K22_07820	COG3539	Fimbrial protein
I6K22_07835	COG3384	dioxygenase
I6K22_07845	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
I6K22_07855	COG0754	glutathionylspermidine amidase activity
I6K22_07865	COG1538	Outer membrane efflux protein
I6K22_07870	COG0494	nUDIX hydrolase
I6K22_07875	COG3151	Protein conserved in bacteria
I6K22_07880	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
I6K22_07885	COG3150	esterase
I6K22_07890	COG0187	DNA topoisomerase II activity
I6K22_07895	COG4774	siderophore transport
I6K22_07900	COG1120	ATPase activity
I6K22_07905	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6K22_07910	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6K22_07920	COG1737	Transcriptional regulator
I6K22_07925	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
I6K22_07930	COG2249	NAD(P)H dehydrogenase (quinone) activity
I6K22_07945	COG0642	Histidine kinase
I6K22_07955	COG3111	PFAM Bacterial OB fold (BOF) protein
I6K22_07960	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
I6K22_07965	COG4166	transmembrane transport
I6K22_07970	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
I6K22_07975	COG0204	Acyl-transferase
I6K22_07980	COG2132	Multicopper oxidase
I6K22_08000	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
I6K22_08005	COG1063	alcohol dehydrogenase
I6K22_08010	COG0246	Mannitol dehydrogenase
I6K22_08015	COG2186	Transcriptional regulator
I6K22_08020	COG1032	radical SAM domain protein
I6K22_08025	COG4238	major outer membrane lipoprotein
I6K22_08035	COG0656	L-ascorbic acid biosynthetic process
I6K22_08040	COG1979	alcohol dehydrogenase
I6K22_08045	COG2207	Transcriptional regulator
I6K22_08050	COG0586	Pfam SNARE associated Golgi protein
I6K22_08055	COG0626	cystathionine gamma-synthase activity
I6K22_08060	COG0811	peptide transport
I6K22_08065	COG0848	biopolymer transport protein
I6K22_08070	COG1028	Short-chain dehydrogenase reductase Sdr
I6K22_08080	COG0667	Aldo Keto reductase
I6K22_08095	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
I6K22_08100	COG0437	4 iron, 4 sulfur cluster binding
I6K22_08105	COG5557	Pfam Polysulphide reductase, NrfD
I6K22_08110	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
I6K22_08115	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
I6K22_08120	COG1773	rubredoxin
I6K22_08125	COG0375	protein maturation
I6K22_08130	COG0298	carbon dioxide binding
I6K22_08135	COG0625	glutathione transferase activity
I6K22_08140	COG0754	glutathionylspermidine amidase activity
I6K22_08145	COG0306	phosphate transporter
I6K22_08150	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
I6K22_08155	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
I6K22_08160	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
I6K22_08165	COG2244	polysaccharide biosynthetic process
I6K22_08175	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
I6K22_08180	COG0795	lipopolysaccharide-transporting ATPase activity
I6K22_08190	COG0156	8-amino-7-oxononanoate synthase activity
I6K22_08195	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I6K22_08205	COG0318	PFAM AMP-dependent synthetase and ligase
I6K22_08210	COG0456	acetyltransferase
I6K22_08215	COG2186	Transcriptional regulator
I6K22_08220	COG0277	FAD linked oxidase domain protein
I6K22_08225	COG0277	FAD linked oxidase domain protein
I6K22_08230	COG0247	lactate metabolic process
I6K22_08235	COG3193	protein, possibly involved in utilization of glycolate and propanediol
I6K22_08240	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
I6K22_08245	COG1620	l-lactate permease
I6K22_08250	COG3064	Membrane
I6K22_08265	COG3031	protein transport across the cell outer membrane
I6K22_08275	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I6K22_08280	COG1459	type II secretion system
I6K22_08285	COG2165	general secretion pathway protein
I6K22_08315	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
I6K22_08335	COG2089	acid synthase
I6K22_08395	COG2771	luxR family
I6K22_08395	COG2200	EAL domain
I6K22_08430	COG2003	Belongs to the UPF0758 family
I6K22_08455	COG2378	regulation of single-species biofilm formation
I6K22_08460	COG3596	GTP binding
I6K22_08485	COG4771	TonB-dependent receptor
I6K22_08510	COG3969	phosphoadenosine phosphosulfate
I6K22_08650	COG2194	sulfuric ester hydrolase activity
I6K22_08655	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6K22_08655	COG1112	Superfamily I DNA and RNA helicases and helicase subunits
I6K22_08660	COG0582	viral genome integration into host DNA
I6K22_08670	COG1811	Na channel or pump
I6K22_08675	COG1982	Orn Lys Arg decarboxylase major
I6K22_08680	COG2211	Major facilitator Superfamily
I6K22_08695	COG1194	a g-specific adenine glycosylase
I6K22_08705	COG3171	Protein conserved in bacteria
I6K22_08715	COG0252	asparaginase activity
I6K22_08725	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I6K22_08730	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
I6K22_08740	COG0762	integral membrane protein
I6K22_08745	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
I6K22_08750	COG2805	Type II/IV secretion system protein
I6K22_08765	COG0189	ligase activity
I6K22_08770	COG1385	rRNA (uridine-N3-)-methyltransferase activity
I6K22_08775	COG2356	endonuclease I
I6K22_08785	COG2814	Major facilitator Superfamily
I6K22_08805	COG1166	arginine decarboxylase activity
I6K22_08820	COG0501	Belongs to the peptidase M48B family
I6K22_08825	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
I6K22_08830	COG0330	HflC and HflK could
I6K22_08835	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K22_08840	COG2213	PTS system mannitol-specific
I6K22_08845	COG1063	alcohol dehydrogenase
I6K22_08860	COG1072	(Pantothenic acid kinase))
I6K22_08865	COG1122	ATPase activity
I6K22_08900	COG0191	fructose-bisphosphate aldolase activity
I6K22_08905	COG0668	transmembrane transport
I6K22_08910	COG1279	arginine transmembrane transporter activity
I6K22_08915	COG2968	Membrane
I6K22_08920	COG0583	DNA-binding transcription factor activity
I6K22_08925	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
I6K22_08925	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
I6K22_08945	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I6K22_08955	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
I6K22_08975	COG0006	proline dipeptidase activity
I6K22_08980	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6K22_08985	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6K22_09010	COG2723	6-phospho-beta-galactosidase activity
I6K22_09020	COG1272	protein, Hemolysin III
I6K22_09030	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
I6K22_09040	COG0716	FMN binding
I6K22_09050	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I6K22_09055	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
I6K22_09065	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
I6K22_09085	COG2233	PERMEase
I6K22_09090	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6K22_09090	COG0493	'glutamate synthase
I6K22_09095	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6K22_09100	COG2252	PERMEase
I6K22_09105	COG0402	S-adenosylhomocysteine deaminase activity
I6K22_09110	COG2233	PERMEase
I6K22_09115	COG2080	2 iron, 2 sulfur cluster binding
I6K22_09115	COG1529	Aldehyde oxidase and xanthine dehydrogenase
I6K22_09120	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
I6K22_09125	COG0402	S-adenosylhomocysteine deaminase activity
I6K22_09130	COG0493	'glutamate synthase
I6K22_09130	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6K22_09135	COG2068	MobA-Related Protein
I6K22_09140	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
I6K22_09145	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
I6K22_09145	COG3608	succinylglutamate desuccinylase aspartoacylase
I6K22_09150	COG0549	Belongs to the carbamate kinase family
I6K22_09160	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I6K22_09165	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I6K22_09170	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
I6K22_09175	COG3829	transcription factor binding
I6K22_09180	COG2080	2 iron, 2 sulfur cluster binding
I6K22_09185	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
I6K22_09190	COG1529	Aldehyde oxidase and xanthine dehydrogenase
I6K22_09195	COG4942	peptidase
I6K22_09205	COG0814	amino acid
I6K22_09210	COG0183	Belongs to the thiolase family
I6K22_09220	COG1028	Short-chain dehydrogenase reductase Sdr
I6K22_09225	COG2814	Major facilitator Superfamily
I6K22_09230	COG1794	racemase activity, acting on amino acids and derivatives
I6K22_09235	COG0583	DNA-binding transcription factor activity
I6K22_09245	COG1609	Transcriptional regulator
I6K22_09260	COG0667	Aldo Keto reductase
I6K22_09270	COG0861	Integral membrane protein TerC family
I6K22_09285	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
I6K22_09300	COG2165	general secretion pathway protein
I6K22_09305	COG4795	General secretion pathway protein
I6K22_09315	COG4967	type IV pilus modification protein PilV
I6K22_09320	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
I6K22_09325	COG1025	Belongs to the peptidase M16 family
I6K22_09330	COG1074	ATP-dependent DNA helicase activity
I6K22_09335	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I6K22_09340	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
I6K22_09340	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
I6K22_09345	COG0860	N-Acetylmuramoyl-L-alanine amidase
I6K22_09350	COG3711	transcriptional antiterminator
I6K22_09355	COG1263	PTS System
I6K22_09355	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6K22_09360	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
I6K22_09505	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
I6K22_09510	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
I6K22_09515	COG2166	iron-sulfur cluster assembly
I6K22_09520	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
I6K22_09530	COG0583	DNA-binding transcription factor activity
I6K22_09535	COG2363	Small membrane protein
I6K22_09545	COG1349	DNA-binding transcription factor activity
I6K22_09555	COG1070	Carbohydrate kinase
I6K22_09565	COG0738	Major facilitator superfamily
I6K22_09570	COG0235	Class ii aldolase
I6K22_09575	COG1454	alcohol dehydrogenase
I6K22_09585	COG1760	l-serine dehydratase
I6K22_09590	COG0814	amino acid
I6K22_09595	COG1611	Belongs to the LOG family
I6K22_09610	COG3098	single-species biofilm formation
I6K22_09615	COG0564	pseudouridine synthase activity
I6K22_09620	COG0716	FMN binding
I6K22_09625	COG2271	Major facilitator Superfamily
I6K22_09630	COG4948	Mandelate Racemase Muconate Lactonizing
I6K22_09635	COG4948	Mandelate Racemase Muconate Lactonizing
I6K22_09640	COG3850	Histidine kinase
I6K22_09640	COG2205	protein histidine kinase activity
I6K22_09640	COG4999	Histidine kinase
I6K22_09640	COG3437	response regulator, receiver
I6K22_09650	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I6K22_09655	COG2336	PFAM SpoVT AbrB
I6K22_09660	COG2337	Toxic component of a toxin-antitoxin (TA) module
I6K22_09665	COG3956	TIGRFAM MazG family protein
I6K22_09680	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
I6K22_09690	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
I6K22_09700	COG0602	queuosine metabolic process
I6K22_09710	COG2223	nitrite transmembrane transporter activity
I6K22_09715	COG1028	Short-chain dehydrogenase reductase Sdr
I6K22_09720	COG0277	FAD linked oxidase domain protein
I6K22_09725	COG0477	Major facilitator Superfamily
I6K22_09730	COG2086	electron transfer activity
I6K22_09735	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
I6K22_09740	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
I6K22_09745	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
I6K22_09750	COG0644	oxidoreductase
I6K22_09755	COG0720	synthase
I6K22_09780	COG2234	aminopeptidase activity
I6K22_09835	COG1388	LysM domain
I6K22_09835	COG4942	peptidase
I6K22_09840	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I6K22_09855	COG2610	gluconate transmembrane transporter activity
I6K22_09860	COG3622	Belongs to the hyi family
I6K22_09865	COG0235	Class ii aldolase
I6K22_09870	COG3395	kinase activity
I6K22_09875	COG2084	Dehydrogenase
I6K22_09880	COG1349	DNA-binding transcription factor activity
I6K22_09885	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
I6K22_09905	COG3604	Transcriptional regulator
I6K22_09910	COG0309	Hydrogenase expression formation protein (HypE)
I6K22_09915	COG0409	Hydrogenase expression formation protein
I6K22_09920	COG0298	carbon dioxide binding
I6K22_09925	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
I6K22_09930	COG0375	protein maturation
I6K22_09940	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6K22_09945	COG0651	ATP synthesis coupled electron transport
I6K22_09950	COG0650	Formate hydrogenlyase subunit 4
I6K22_09955	COG3261	NADH dehydrogenase
I6K22_09955	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
I6K22_09960	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6K22_09965	COG3260	NADH ubiquinone oxidoreductase 20
I6K22_09975	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
I6K22_09985	COG5499	transcription regulator containing HTH domain
I6K22_09990	COG2723	6-phospho-beta-galactosidase activity
I6K22_09995	COG1263	PTS System
I6K22_09995	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6K22_10000	COG1609	Transcriptional regulator
I6K22_10005	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6K22_10010	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
I6K22_10030	COG0517	IMP dehydrogenase activity
I6K22_10030	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
I6K22_10035	COG1349	DNA-binding transcription factor activity
I6K22_10040	COG4578	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K22_10045	COG1028	Short-chain dehydrogenase reductase Sdr
I6K22_10055	COG3732	PTS system glucitol sorbitol-specific
I6K22_10060	COG3730	PTS system glucitol sorbitol-specific
I6K22_10065	COG2951	lytic endotransglycosylase activity
I6K22_10070	COG1546	Belongs to the CinA family
I6K22_10090	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
I6K22_10115	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6K22_10120	COG1238	metal cluster binding
I6K22_10145	COG2814	Major facilitator Superfamily
I6K22_10150	COG1566	PFAM secretion protein HlyD family protein
I6K22_10155	COG1846	Transcriptional regulator
I6K22_10165	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
I6K22_10170	COG2814	Major facilitator Superfamily
I6K22_10175	COG2113	Glycine betaine
I6K22_10180	COG4176	ABC-type proline glycine betaine transport system permease component
I6K22_10185	COG4175	Glycine betaine
I6K22_10190	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6K22_10195	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6K22_10205	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
I6K22_10210	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I6K22_10220	COG4575	ribosome binding
I6K22_10235	COG2916	Histone family protein nucleoid-structuring protein H-NS
I6K22_10240	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I6K22_10245	COG0640	Transcriptional regulator
I6K22_10250	COG0401	homolog of Blt101
I6K22_10255	COG1652	LysM domain
I6K22_10260	COG1802	Transcriptional regulator
I6K22_10265	COG1113	amino acid transport
I6K22_10270	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
I6K22_10275	COG1012	belongs to the aldehyde dehydrogenase family
I6K22_10280	COG0579	oxidoreductase
I6K22_10305	COG0582	viral genome integration into host DNA
I6K22_10320	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
I6K22_10325	COG5532	Uncharacterized conserved protein (DUF2303)
I6K22_10345	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
I6K22_10350	COG4197	protein conserved in bacteria, prophage-related
I6K22_10365	COG1846	Transcriptional regulator
I6K22_10375	COG4725	Belongs to the MT-A70-like family
I6K22_10385	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
I6K22_10395	COG1403	HNH endonuclease
I6K22_10400	COG0484	heat shock protein binding
I6K22_10445	COG4626	Terminase
I6K22_10445	COG1802	Transcriptional regulator
I6K22_10455	COG4695	Portal protein
I6K22_10500	COG4386	tail sheath protein
I6K22_10520	COG4228	DNA circulation
I6K22_10540	COG3299	homolog of phage Mu protein gp47
I6K22_10545	COG3778	Protein conserved in bacteria
I6K22_10555	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
I6K22_10610	COG2867	negative regulation of translational initiation
I6K22_10620	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6K22_10625	COG0497	DNA recombination
I6K22_10640	COG4536	flavin adenine dinucleotide binding
I6K22_10645	COG4137	Cytochrome C assembly protein
I6K22_10650	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
I6K22_10675	COG2885	chlorophyll binding
I6K22_10680	COG2199	diguanylate cyclase activity
I6K22_10695	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I6K22_10700	COG1605	Chorismate mutase
I6K22_10700	COG0287	Prephenate dehydrogenase
I6K22_10705	COG1605	Chorismate mutase
I6K22_10705	COG0077	Prephenate dehydratase
I6K22_10715	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
I6K22_10720	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6K22_10725	COG0564	pseudouridine synthase activity
I6K22_10735	COG0542	response to heat
I6K22_10770	COG0477	Major facilitator Superfamily
I6K22_10775	COG5544	Lipoprotein
I6K22_10780	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6K22_10785	COG1042	CoA-binding domain protein
I6K22_10785	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6K22_10785	COG0045	succinate-CoA ligase (ADP-forming) activity
I6K22_10790	COG3148	PFAM DTW domain containing protein
I6K22_10795	COG3118	belongs to the thioredoxin family
I6K22_10800	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6K22_10820	COG0583	DNA-binding transcription factor activity
I6K22_10825	COG0513	Belongs to the DEAD box helicase family
I6K22_10835	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
I6K22_10845	COG1595	DNA-templated transcription, initiation
I6K22_10850	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
I6K22_10855	COG3026	antisigma factor binding
I6K22_10860	COG3086	response to oxidative stress
I6K22_10870	COG0681	Belongs to the peptidase S26 family
I6K22_10890	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
I6K22_10905	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6K22_10910	COG1737	Transcriptional regulator
I6K22_10915	COG0560	Phosphoserine phosphatase
I6K22_10920	COG0590	tRNA wobble adenosine to inosine editing
I6K22_10935	COG2205	protein histidine kinase activity
I6K22_10940	COG3170	Tfp pilus assembly protein FimV
I6K22_10945	COG2204	response regulator
I6K22_10950	COG0347	Belongs to the P(II) protein family
I6K22_10955	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6K22_10955	COG1017	nitric oxide dioxygenase activity
I6K22_10965	COG1940	carbohydrate kinase activity
I6K22_10970	COG0457	Tetratricopeptide repeat
I6K22_10975	COG1879	ABC-type sugar transport system periplasmic component
I6K22_10980	COG1129	ABC transporter
I6K22_10985	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6K22_10990	COG1063	alcohol dehydrogenase
I6K22_10995	COG2017	converts alpha-aldose to the beta-anomer
I6K22_11000	COG2259	Doxx family
I6K22_11005	COG2814	Major facilitator Superfamily
I6K22_11010	COG3711	transcriptional antiterminator
I6K22_11015	COG1073	alpha beta
I6K22_11020	COG0483	inositol monophosphate 1-phosphatase activity
I6K22_11040	COG0822	iron-sulfur transferase activity
I6K22_11060	COG0633	Ferredoxin
I6K22_11065	COG2975	iron-sulfur cluster assembly
I6K22_11080	COG2897	thiosulfate sulfurtransferase activity
I6K22_11085	COG2373	Large extracellular alpha-helical protein
I6K22_11090	COG4953	penicillin-binding protein 1C
I6K22_11120	COG2976	Protein conserved in bacteria
I6K22_11135	COG1645	bacterial-type flagellum-dependent swarming motility
I6K22_11160	COG0517	IMP dehydrogenase activity
I6K22_11160	COG0516	GMP reductase activity
I6K22_11175	COG3133	Outer membrane lipoprotein
I6K22_11190	COG2200	EAL domain
I6K22_11195	COG0248	Ppx GppA phosphatase
I6K22_11200	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
I6K22_11205	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
I6K22_11220	COG2233	PERMEase
I6K22_11230	COG1393	Belongs to the ArsC family
I6K22_11235	COG4783	chaperone-mediated protein folding
I6K22_11240	COG0628	permease
I6K22_11245	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
I6K22_11250	COG2716	regulation of RNA biosynthetic process
I6K22_11260	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
I6K22_11270	COG2321	neutral zinc metallopeptidase
I6K22_11280	COG0400	carboxylic ester hydrolase activity
I6K22_11295	COG1393	Belongs to the ArsC family
I6K22_11305	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6K22_11310	COG3850	Histidine kinase
I6K22_11315	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6K22_11315	COG0493	'glutamate synthase
I6K22_11325	COG5342	invasion associated locus B
I6K22_11330	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
I6K22_11335	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
I6K22_11340	COG0280	phosphate acetyltransferase
I6K22_11340	COG0281	malic enzyme
I6K22_11345	COG4810	utilization protein
I6K22_11350	COG4917	ethanolamine utilization protein
I6K22_11355	COG4766	ethanolamine catabolic process
I6K22_11360	COG4812	Cobalamin adenosyltransferase
I6K22_11365	COG0280	phosphate acetyltransferase
I6K22_11370	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
I6K22_11375	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
I6K22_11380	COG1012	belongs to the aldehyde dehydrogenase family
I6K22_11385	COG4820	ethanolamine utilization protein (EutJ)
I6K22_11390	COG1454	alcohol dehydrogenase
I6K22_11395	COG3192	ethanolamine utilization protein
I6K22_11400	COG4819	ethanolamine utilization protein
I6K22_11405	COG4303	Ethanolamine ammonia lyase large subunit
I6K22_11415	COG4816	utilization protein
I6K22_11420	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
I6K22_11425	COG2207	Transcriptional regulator
I6K22_11435	COG0860	N-Acetylmuramoyl-L-alanine amidase
I6K22_11455	COG2837	iron assimilation
I6K22_11470	COG1028	Short-chain dehydrogenase reductase Sdr
I6K22_11475	COG4150	thiosulfate binding
I6K22_11480	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
I6K22_11485	COG4208	sulfate ABC transporter
I6K22_11490	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
I6K22_11495	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I6K22_11510	COG2190	(PTS) system
I6K22_11515	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I6K22_11520	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K22_11525	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I6K22_11545	COG3530	Putative quorum-sensing-regulated virulence factor
I6K22_11550	COG0385	Bile acid
I6K22_11555	COG0583	DNA-binding transcription factor activity
I6K22_11565	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
I6K22_11570	COG2211	Major facilitator Superfamily
I6K22_11580	COG0583	DNA-binding transcription factor activity
I6K22_11610	COG3415	Transposase
I6K22_11615	COG3415	Transposase
I6K22_11630	COG2200	EAL domain
I6K22_11630	COG2199	diguanylate cyclase activity
I6K22_11635	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I6K22_11660	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6K22_11665	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6K22_11670	COG0006	proline dipeptidase activity
I6K22_11675	COG1363	Peptidase, m42
I6K22_11685	COG2207	Transcriptional regulator
I6K22_11690	COG3279	Response regulator of the LytR AlgR family
I6K22_11695	COG3275	phosphorelay sensor kinase activity
I6K22_11700	COG0436	Aminotransferase
I6K22_11710	COG1560	Kdo2-lipid A biosynthetic process
I6K22_11735	COG0028	Belongs to the TPP enzyme family
I6K22_11740	COG0679	Auxin Efflux Carrier
I6K22_11745	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I6K22_11750	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6K22_11750	COG2198	Histidine kinase
I6K22_11750	COG2205	protein histidine kinase activity
I6K22_11750	COG0784	Response regulator, receiver
I6K22_11755	COG2197	response regulator
I6K22_11760	COG1566	PFAM secretion protein HlyD family protein
I6K22_11765	COG0477	Major facilitator Superfamily
I6K22_11775	COG2610	gluconate transmembrane transporter activity
I6K22_11780	COG0583	DNA-binding transcription factor activity
I6K22_11790	COG2116	formate transmembrane transporter activity
I6K22_11800	COG2067	long-chain fatty acid transport protein
I6K22_11805	COG3691	Protein conserved in bacteria
I6K22_11820	COG2062	phosphohistidine phosphatase, SixA
I6K22_11830	COG3188	usher protein
I6K22_11835	COG3121	Chaperone
I6K22_11840	COG3539	Fimbrial protein
I6K22_11845	COG3539	Fimbrial protein
I6K22_11850	COG3539	Fimbrial protein
I6K22_11880	COG0730	response to heat
I6K22_11885	COG3101	peptidyl-lysine hydroxylation
I6K22_11900	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I6K22_11905	COG2814	Major facilitator Superfamily
I6K22_11920	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
I6K22_11940	COG0285	dihydrofolate synthase activity
I6K22_11945	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
I6K22_11950	COG1286	toxin biosynthetic process
I6K22_11955	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
I6K22_11960	COG0163	prenyltransferase activity
I6K22_11965	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6K22_11970	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6K22_11975	COG4215	(ABC) transporter
I6K22_11980	COG4160	amino acid transport
I6K22_11985	COG4598	ABC transporter
I6K22_11990	COG5464	transposase or invertase
I6K22_11995	COG1090	epimerase
I6K22_12000	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
I6K22_12005	COG0625	glutathione transferase activity
I6K22_12010	COG0625	glutathione transferase activity
I6K22_12015	COG0622	Phosphoesterase
I6K22_12020	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
I6K22_12025	COG1288	antiporter activity
I6K22_12030	COG0857	belongs to the CobB CobQ family
I6K22_12030	COG0280	phosphate acetyltransferase
I6K22_12035	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
I6K22_12050	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6K22_12055	COG0471	metal ion transport
I6K22_12055	COG0490	domain, Protein
I6K22_12065	COG0436	Aminotransferase
I6K22_12070	COG0583	DNA-binding transcription factor activity
I6K22_12090	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
I6K22_12095	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
I6K22_12100	COG1034	ATP synthesis coupled electron transport
I6K22_12115	COG0839	Belongs to the complex I subunit 6 family
I6K22_12125	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I6K22_12130	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6K22_12145	COG2234	aminopeptidase activity
I6K22_12150	COG2304	oxidoreductase activity
I6K22_12160	COG2153	protein acetylation
I6K22_12165	COG4575	ribosome binding
I6K22_12170	COG1169	isochorismate synthase
I6K22_12185	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
I6K22_12195	COG0318	PFAM AMP-dependent synthetase and ligase
I6K22_12260	COG1414	Transcriptional regulator
I6K22_12270	COG2271	Major facilitator Superfamily
I6K22_12285	COG5464	transposase or invertase
I6K22_12290	COG0247	lactate metabolic process
I6K22_12300	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
I6K22_12305	COG2271	Major facilitator Superfamily
I6K22_12310	COG0584	glycerophosphoryl diester phosphodiesterase
I6K22_12315	COG3642	lipopolysaccharide core region biosynthetic process
I6K22_12320	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6K22_12325	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6K22_12330	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6K22_12335	COG3468	outer membrane autotransporter barrel domain protein
I6K22_12345	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
I6K22_12350	COG4685	Uncharacterized protein conserved in bacteria (DUF2138)
I6K22_12360	COG2373	Large extracellular alpha-helical protein
I6K22_12365	COG5445	Predicted secreted protein (DUF2300)
I6K22_12370	COG4676	Protein conserved in bacteria
I6K22_12375	COG0183	Belongs to the thiolase family
I6K22_12380	COG2031	fatty acid transporter
I6K22_12385	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
I6K22_12390	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
I6K22_12395	COG2204	response regulator
I6K22_12400	COG3852	Histidine kinase
I6K22_12405	COG0784	Response regulator, receiver
I6K22_12405	COG2205	protein histidine kinase activity
I6K22_12410	COG2197	response regulator
I6K22_12415	COG2198	Histidine kinase
I6K22_12415	COG0642	Histidine kinase
I6K22_12420	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
I6K22_12425	COG1477	protein flavinylation
I6K22_12430	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I6K22_12430	COG2169	Transcriptional regulator
I6K22_12435	COG3145	DNA-N1-methyladenine dioxygenase activity
I6K22_12440	COG4615	Cyclic peptide transporter
I6K22_12455	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6K22_12455	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6K22_12460	COG3062	negative regulation of establishment of protein localization
I6K22_12470	COG0437	4 iron, 4 sulfur cluster binding
I6K22_12475	COG0348	domain, Protein
I6K22_12480	COG3043	anaerobic respiration
I6K22_12485	COG3005	denitrification pathway
I6K22_12495	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I6K22_12500	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I6K22_12505	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I6K22_12515	COG1138	Cytochrome C-type biogenesis protein
I6K22_12520	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6K22_12525	COG3088	subunit of a heme lyase
I6K22_12525	COG4235	cytochrome complex assembly
I6K22_12530	COG2197	response regulator
I6K22_12545	COG3083	sulfuric ester hydrolase activity
I6K22_12565	COG1061	Type III restriction enzyme res subunit
I6K22_12570	COG1187	pseudouridine synthase activity
I6K22_12575	COG2814	Major facilitator Superfamily
I6K22_12585	COG4172	Belongs to the ABC transporter superfamily
I6K22_12590	COG4239	(ABC) transporter, permease
I6K22_12595	COG4174	ABC transporter (Permease)
I6K22_12600	COG4166	transmembrane transport
I6K22_12605	COG2200	EAL domain
I6K22_12610	COG0791	NLP P60 protein
I6K22_12615	COG0671	phosphoesterase, PA-phosphatase related
I6K22_12620	COG0523	cobalamin synthesis protein
I6K22_12625	COG0246	Mannitol dehydrogenase
I6K22_12640	COG2814	Major facilitator Superfamily
I6K22_12645	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K22_12645	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K22_12650	COG1105	Belongs to the carbohydrate kinase PfkB family
I6K22_12655	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6K22_12655	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
I6K22_12655	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6K22_12660	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6K22_12665	COG2313	pseudouridylate synthase activity
I6K22_12670	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I6K22_12675	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I6K22_12685	COG1522	sequence-specific DNA binding
I6K22_12685	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6K22_12695	COG2855	membrane
I6K22_12700	COG0583	DNA-binding transcription factor activity
I6K22_12705	COG0833	amino acid
I6K22_12710	COG4771	TonB-dependent receptor
I6K22_12725	COG2311	Membrane
I6K22_12730	COG1609	Transcriptional regulator
I6K22_12735	COG1879	ABC-type sugar transport system periplasmic component
I6K22_12745	COG4211	Belongs to the binding-protein-dependent transport system permease family
I6K22_12750	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
I6K22_12750	COG0167	dihydroorotate dehydrogenase activity
I6K22_12755	COG0493	'glutamate synthase
I6K22_12765	COG2949	membrane
I6K22_12775	COG1346	cytolysis
I6K22_12785	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I6K22_12795	COG1538	Outer membrane efflux protein
I6K22_12800	COG1028	Short-chain dehydrogenase reductase Sdr
I6K22_12805	COG0586	Pfam SNARE associated Golgi protein
I6K22_12815	COG1686	Belongs to the peptidase S11 family
I6K22_12820	COG0277	FAD linked oxidase domain protein
I6K22_12825	COG1472	Belongs to the glycosyl hydrolase 3 family
I6K22_12830	COG1732	Glycine betaine
I6K22_12835	COG1174	glycine betaine transport
I6K22_12840	COG1125	glycine betaine transport
I6K22_12845	COG1174	glycine betaine transport
I6K22_12855	COG0789	Transcriptional regulator
I6K22_12860	COG3275	phosphorelay sensor kinase activity
I6K22_12865	COG3279	Response regulator of the LytR AlgR family
I6K22_12870	COG4807	Protein conserved in bacteria
I6K22_12875	COG4808	Protein conserved in bacteria
I6K22_12880	COG4715	Zinc finger, swim domain protein
I6K22_12885	COG3552	Protein containing von Willebrand factor type A (VWA) domain
I6K22_12890	COG2425	protein containing a von Willebrand factor type A (vWA) domain
I6K22_12895	COG0714	Associated with various cellular activities
I6K22_12905	COG3831	ATPase activity
I6K22_12910	COG3831	ATPase activity
I6K22_12920	COG0489	protein tyrosine kinase activity
I6K22_12930	COG3539	Fimbrial protein
I6K22_12935	COG3121	Chaperone
I6K22_12940	COG3188	usher protein
I6K22_12945	COG3539	Fimbrial protein
I6K22_12950	COG5455	response to cobalt ion
I6K22_12970	COG0351	phosphomethylpyrimidine kinase
I6K22_12975	COG3757	hydrolase, family 25
I6K22_12980	COG2188	Transcriptional regulator
I6K22_12985	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6K22_12990	COG1397	ADP-ribosylglycohydrolase
I6K22_12995	COG2211	Major facilitator Superfamily
I6K22_13000	COG1830	Aldolase
I6K22_13015	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K22_13020	COG3414	Phosphotransferase system galactitol-specific IIB component
I6K22_13025	COG3775	system Galactitol-specific IIC component
I6K22_13030	COG1063	alcohol dehydrogenase
I6K22_13050	COG0826	peptidase U32
I6K22_13075	COG3422	double-strand break repair
I6K22_13080	COG0745	RESPONSE REGULATOR receiver
I6K22_13085	COG2205	protein histidine kinase activity
I6K22_13120	COG4245	von Willebrand factor, type A
I6K22_13125	COG0631	protein serine/threonine phosphatase activity
I6K22_13130	COG4248	protein with protein kinase and helix-hairpin-helix DNA-binding domains
I6K22_13135	COG0443	Heat shock 70 kDa protein
I6K22_13140	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
I6K22_13145	COG5002	protein histidine kinase activity
I6K22_13145	COG3447	MASE1 domain protein
I6K22_13145	COG5001	Diguanylate cyclase
I6K22_13150	COG0572	uridine kinase
I6K22_13160	COG2982	Protein involved in outer membrane biogenesis
I6K22_13175	COG1253	flavin adenine dinucleotide binding
I6K22_13185	COG1596	polysaccharide export
I6K22_13190	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I6K22_13195	COG0489	protein tyrosine kinase activity
I6K22_13195	COG3206	protein involved in exopolysaccharide biosynthesis
I6K22_13200	COG0463	Glycosyl transferase, family 2
I6K22_13205	COG1045	serine acetyltransferase
I6K22_13210	COG0438	transferase activity, transferring glycosyl groups
I6K22_13220	COG1216	Glycosyl transferase, family 2
I6K22_13225	COG0110	maltose O-acetyltransferase activity
I6K22_13230	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
I6K22_13235	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6K22_13240	COG1051	belongs to the nudix hydrolase family
I6K22_13245	COG0297	glycogen (starch) synthase activity
I6K22_13250	COG0662	Cupin 2, conserved barrel domain protein
I6K22_13250	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
I6K22_13255	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I6K22_13260	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
I6K22_13265	COG2244	polysaccharide biosynthetic process
I6K22_13270	COG2327	Polysaccharide pyruvyl transferase
I6K22_13275	COG0438	transferase activity, transferring glycosyl groups
I6K22_13285	COG1210	Utp--glucose-1-phosphate uridylyltransferase
I6K22_13290	COG1088	dTDP-glucose 4,6-dehydratase activity
I6K22_13295	COG1091	dTDP-4-dehydrorhamnose reductase activity
I6K22_13300	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
I6K22_13315	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
I6K22_13330	COG0463	Glycosyl transferase, family 2
I6K22_13340	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
I6K22_13345	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
I6K22_13350	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
I6K22_13355	COG0140	phosphoribosyl-ATP diphosphatase activity
I6K22_13355	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
I6K22_13370	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
I6K22_13375	COG0131	Imidazoleglycerol-phosphate dehydratase
I6K22_13375	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
I6K22_13385	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
I6K22_13400	COG2161	toxin-antitoxin pair type II binding
I6K22_13405	COG4115	mRNA cleavage
I6K22_13410	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6K22_13415	COG0583	DNA-binding transcription factor activity
I6K22_13425	COG0531	amino acid
I6K22_13430	COG2925	Exonuclease
I6K22_13435	COG1686	Belongs to the peptidase S11 family
I6K22_13445	COG1289	transmembrane transporter activity
I6K22_13490	COG2003	Belongs to the UPF0758 family
I6K22_13545	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6K22_13550	COG1120	ATPase activity
I6K22_13605	COG3547	Transposase (IS116 IS110 IS902 family)
I6K22_13640	COG1735	metal-dependent hydrolase with the TIM-barrel fold
I6K22_13655	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6K22_13665	COG3547	Transposase (IS116 IS110 IS902 family)
I6K22_13680	COG1215	transferase activity, transferring glycosyl groups
I6K22_13685	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
I6K22_13690	COG3969	phosphoadenosine phosphosulfate
I6K22_13695	COG1475	DNA binding
I6K22_13700	COG4771	TonB-dependent receptor
I6K22_13705	COG2087	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate
I6K22_13720	COG1376	ErfK ybiS ycfS ynhG family protein
I6K22_13740	COG2197	response regulator
I6K22_13755	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6K22_13760	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I6K22_13765	COG1960	acyl-CoA dehydrogenase activity
I6K22_13790	COG0154	amidase activity
I6K22_13815	COG3208	Thioesterase involved in non-ribosomal peptide biosynthesis
I6K22_13825	COG0582	viral genome integration into host DNA
I6K22_13835	COG0534	Mate efflux family protein
I6K22_13845	COG0583	DNA-binding transcription factor activity
I6K22_13850	COG0583	DNA-binding transcription factor activity
I6K22_13860	COG0217	transcriptional regulatory protein
I6K22_13865	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
I6K22_13870	COG0477	Major facilitator Superfamily
I6K22_13885	COG4932	domain protein
I6K22_13885	COG1388	LysM domain
I6K22_13885	COG2373	Large extracellular alpha-helical protein
I6K22_13890	COG4771	TonB-dependent receptor
I6K22_13895	COG1021	2,3-dihydroxybenzoate-AMP ligase
I6K22_13915	COG3433	isochorismatase activity
I6K22_13915	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I6K22_13915	COG2226	methyltransferase
I6K22_13930	COG1132	(ABC) transporter
I6K22_13935	COG2814	Major facilitator Superfamily
I6K22_13945	COG0582	viral genome integration into host DNA
I6K22_14055	COG4916	TIR domain
I6K22_14085	COG0582	viral genome integration into host DNA
I6K22_14090	COG3443	Belongs to the bacterial solute-binding protein 9 family
I6K22_14095	COG2717	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. MsrQ provides electrons for reduction to the reductase catalytic subunit MsrP, using the quinone pool of the respiratory chain
I6K22_14100	COG2041	Part of the MsrPQ system that repairs oxidized periplasmic proteins containing methionine sulfoxide residues (Met-O), using respiratory chain electrons. Thus protects these proteins from oxidative-stress damage caused by reactive species of oxygen and chlorine generated by the host defense mechanisms. MsrPQ is essential for the maintenance of envelope integrity under bleach stress, rescuing a wide series of structurally unrelated periplasmic proteins from methionine oxidation. The catalytic subunit MsrP is non-stereospecific, being able to reduce both (R-) and (S-) diastereoisomers of methionine sulfoxide
I6K22_14105	COG2351	hydroxyisourate hydrolase activity
I6K22_14110	COG0745	RESPONSE REGULATOR receiver
I6K22_14115	COG2205	protein histidine kinase activity
I6K22_14125	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
I6K22_14135	COG1418	mRNA catabolic process
I6K22_14140	COG0270	DNA (cytosine-5-)-methyltransferase activity
I6K22_14145	COG3727	T/G mismatch-specific endonuclease activity
I6K22_14150	COG0697	spore germination
I6K22_14155	COG2354	Protein conserved in bacteria
I6K22_14160	COG5475	Uncharacterized small protein (DUF2158)
I6K22_14165	COG3706	GGDEF domain
I6K22_14170	COG3769	mannosylglycerate metabolic process
I6K22_14185	COG2197	response regulator
I6K22_14190	COG1684	flagellar biosynthetic protein fliR
I6K22_14195	COG1987	bacterial-type flagellum assembly
I6K22_14200	COG1338	Plays a role in the flagellum-specific transport system
I6K22_14205	COG3190	flagellar
I6K22_14210	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
I6K22_14215	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
I6K22_14220	COG1580	Controls the rotational direction of flagella during chemotaxis
I6K22_14225	COG3144	bacterial-type flagellum assembly
I6K22_14230	COG2882	bacterial-type flagellum organization
I6K22_14235	COG1157	protein secretion by the type III secretion system
I6K22_14240	COG1317	bacterial-type flagellum organization
I6K22_14245	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
I6K22_14250	COG1766	The M ring may be actively involved in energy transduction
I6K22_14260	COG2076	Multidrug Resistance protein
I6K22_14265	COG1881	PFAM PEBP family protein
I6K22_14270	COG2207	Transcriptional regulator
I6K22_14285	COG2135	peptidase activity
I6K22_14290	COG0425	Belongs to the sulfur carrier protein TusA family
I6K22_14295	COG2391	methyltransferase activity
I6K22_14305	COG0366	Alpha amylase catalytic
I6K22_14315	COG1516	flagellar protein fliS
I6K22_14320	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
I6K22_14330	COG1191	sigma factor activity
I6K22_14340	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6K22_14350	COG0765	amino acid transport
I6K22_14355	COG1126	abc transporter atp-binding protein
I6K22_14360	COG2197	response regulator
I6K22_14375	COG2197	response regulator
I6K22_14405	COG3012	SEC-C Motif Domain Protein
I6K22_14405	COG3318	Belongs to the UPF0149 family
I6K22_14410	COG0814	amino acid
I6K22_14420	COG1528	Iron-storage protein
I6K22_14440	COG1528	Iron-storage protein
I6K22_14445	COG1879	ABC-type sugar transport system periplasmic component
I6K22_14455	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6K22_14460	COG1877	trehalose-phosphatase activity
I6K22_14470	COG0589	response to stress
I6K22_14485	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
I6K22_14490	COG1360	Flagellar Motor Protein
I6K22_14495	COG0643	Histidine kinase
I6K22_14495	COG2198	Histidine kinase
I6K22_14500	COG0835	chemotaxis
I6K22_14505	COG0840	transmembrane signaling receptor activity
I6K22_14515	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
I6K22_14525	COG0745	RESPONSE REGULATOR receiver
I6K22_14530	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
I6K22_14535	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
I6K22_14540	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
I6K22_14555	COG3102	Protein conserved in bacteria
I6K22_14565	COG3005	denitrification pathway
I6K22_14570	COG0243	molybdopterin cofactor binding
I6K22_14585	COG3788	relative of glutathione S-transferase, MAPEG superfamily
I6K22_14590	COG1801	Protein of unknown function DUF72
I6K22_14595	COG1335	isochorismatase
I6K22_14605	COG0494	nUDIX hydrolase
I6K22_14610	COG0217	transcriptional regulatory protein
I6K22_14640	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I6K22_14650	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
I6K22_14655	COG0739	heme binding
I6K22_14660	COG1560	Kdo2-lipid A biosynthetic process
I6K22_14665	COG0469	pyruvate kinase activity
I6K22_14670	COG1737	Transcriptional regulator
I6K22_14675	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
I6K22_14680	COG0129	dihydroxy-acid dehydratase activity
I6K22_14685	COG0800	Aldolase
I6K22_14695	COG3141	response to X-ray
I6K22_14705	COG2979	Protein of unknown function (DUF533)
I6K22_14710	COG1770	oligopeptidase
I6K22_14715	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I6K22_14720	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I6K22_14730	COG2372	response to copper ion
I6K22_14735	COG1276	copper resistance
I6K22_14745	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
I6K22_14765	COG3008	intermembrane lipid transfer
I6K22_14770	COG2995	paraquat-inducible protein a
I6K22_14775	COG1956	GAF domain-containing protein
I6K22_14785	COG0793	Belongs to the peptidase S41A family
I6K22_14795	COG2814	Major facilitator Superfamily
I6K22_14800	COG1414	Transcriptional regulator
I6K22_14830	COG2226	methyltransferase
I6K22_14845	COG3716	PTS system mannose fructose sorbose family IID component
I6K22_14850	COG3715	PTS system
I6K22_14855	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6K22_14855	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K22_14860	COG1253	flavin adenine dinucleotide binding
I6K22_14865	COG2200	EAL domain
I6K22_14870	COG1760	l-serine dehydratase
I6K22_14880	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
I6K22_14895	COG0251	oxidation-reduction process
I6K22_14900	COG1199	ATP-dependent helicase activity
I6K22_14905	COG1214	PFAM Peptidase M22, glycoprotease
I6K22_14910	COG3065	identical protein binding
I6K22_14915	COG0318	PFAM AMP-dependent synthetase and ligase
I6K22_14920	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
I6K22_14925	COG0583	DNA-binding transcription factor activity
I6K22_14935	COG3615	Tellurite resistance protein tehB
I6K22_14945	COG2261	transglycosylase associated protein
I6K22_14960	COG2199	diguanylate cyclase activity
I6K22_14960	COG2203	Gaf domain
I6K22_14965	COG3042	response to heat
I6K22_14970	COG3189	MarR family transcriptional regulator
I6K22_14975	COG2807	transmembrane transport
I6K22_14980	COG2207	Transcriptional regulator
I6K22_14995	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
I6K22_15000	COG2199	diguanylate cyclase activity
I6K22_15005	COG2199	diguanylate cyclase activity
I6K22_15015	COG2766	serine protein kinase
I6K22_15020	COG3713	MltA-interacting MipA family protein
I6K22_15025	COG0656	L-ascorbic acid biosynthetic process
I6K22_15030	COG0676	glucose-6-phosphate 1-epimerase activity
I6K22_15035	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
I6K22_15045	COG3139	Protein of unknown function (DUF1315)
I6K22_15050	COG1063	alcohol dehydrogenase
I6K22_15055	COG2271	Major facilitator Superfamily
I6K22_15060	COG1063	alcohol dehydrogenase
I6K22_15065	COG0191	fructose-bisphosphate aldolase activity
I6K22_15070	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6K22_15075	COG0667	Aldo Keto reductase
I6K22_15080	COG1349	DNA-binding transcription factor activity
I6K22_15085	COG2814	Major facilitator Superfamily
I6K22_15090	COG1335	isochorismatase
I6K22_15095	COG0252	asparaginase activity
I6K22_15100	COG0616	signal peptide processing
I6K22_15105	COG0778	Nitroreductase
I6K22_15115	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I6K22_15120	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I6K22_15130	COG0494	nUDIX hydrolase
I6K22_15135	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
I6K22_15140	COG2897	thiosulfate sulfurtransferase activity
I6K22_15145	COG4136	ATPase activity
I6K22_15150	COG4135	transport system, permease component
I6K22_15155	COG4134	Bacterial extracellular solute-binding protein
I6K22_15160	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I6K22_15165	COG0398	Pfam SNARE associated Golgi protein
I6K22_15175	COG0398	Pfam SNARE associated Golgi protein
I6K22_15180	COG0708	Exodeoxyribonuclease III
I6K22_15210	COG3678	ATP-independent chaperone mediated protein folding
I6K22_15220	COG0322	excinuclease ABC activity
I6K22_15230	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6K22_15235	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6K22_15240	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6K22_15245	COG1447	Phosphotransferase system cellobiose-specific component IIA
I6K22_15250	COG1917	Cupin 2, conserved barrel domain protein
I6K22_15250	COG2169	Transcriptional regulator
I6K22_15255	COG1486	melibiose metabolic process
I6K22_15265	COG0753	catalase activity
I6K22_15275	COG1823	symporter activity
I6K22_15280	COG1988	membrane-bound metal-dependent
I6K22_15285	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6K22_15295	COG3001	Fructosamine kinase
I6K22_15305	COG1105	Belongs to the carbohydrate kinase PfkB family
I6K22_15310	COG3137	Salt-induced outer membrane protein
I6K22_15370	COG0386	Belongs to the glutathione peroxidase family
I6K22_15380	COG0791	NLP P60 protein
I6K22_15385	COG2200	EAL domain
I6K22_15395	COG4256	Hemin uptake protein
I6K22_15400	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I6K22_15410	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I6K22_15410	COG0574	Belongs to the PEP-utilizing enzyme family
I6K22_15415	COG0318	PFAM AMP-dependent synthetase and ligase
I6K22_15420	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
I6K22_15425	COG0644	oxidoreductase
I6K22_15430	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
I6K22_15435	COG2086	electron transfer activity
I6K22_15440	COG2207	Transcriptional regulator
I6K22_15440	COG1917	Cupin 2, conserved barrel domain protein
I6K22_15445	COG1960	acyl-CoA dehydrogenase activity
I6K22_15450	COG4670	ketone body catabolic process
I6K22_15465	COG2271	Major facilitator Superfamily
I6K22_15470	COG0738	Major facilitator superfamily
I6K22_15485	COG0628	permease
I6K22_15490	COG0247	lactate metabolic process
I6K22_15490	COG0277	FAD linked oxidase domain protein
I6K22_15495	COG2050	protein possibly involved in aromatic compounds catabolism
I6K22_15505	COG0316	Belongs to the HesB IscA family
I6K22_15510	COG0719	Fe-S assembly protein
I6K22_15515	COG0396	ATPase activity
I6K22_15520	COG0719	Fe-S assembly protein
I6K22_15535	COG1376	ErfK ybiS ycfS ynhG family protein
I6K22_15540	COG4238	major outer membrane lipoprotein
I6K22_15545	COG0469	pyruvate kinase activity
I6K22_15555	COG0437	4 iron, 4 sulfur cluster binding
I6K22_15560	COG2414	aldehyde ferredoxin oxidoreductase
I6K22_15570	COG0437	4 iron, 4 sulfur cluster binding
I6K22_15575	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
I6K22_15585	COG4529	Protein conserved in bacteria
I6K22_15605	COG3468	outer membrane autotransporter barrel domain protein
I6K22_15615	COG0307	riboflavin synthase, alpha
I6K22_15620	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
I6K22_15625	COG2814	Major facilitator Superfamily
I6K22_15630	COG0583	DNA-binding transcription factor activity
I6K22_15645	COG2814	Major facilitator Superfamily
I6K22_15650	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
I6K22_15655	COG0791	NLP P60 protein
I6K22_15660	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
I6K22_15665	COG1201	RNA secondary structure unwinding
I6K22_15675	COG0346	lactoylglutathione lyase activity
I6K22_15680	COG1902	pentaerythritol trinitrate reductase activity
I6K22_15685	COG1309	transcriptional regulator
I6K22_15690	COG3313	Fe-S protein
I6K22_15695	COG4989	oxidoreductase activity
I6K22_15700	COG2032	superoxide dismutase activity
I6K22_15705	COG1289	transmembrane transporter activity
I6K22_15710	COG1566	PFAM secretion protein HlyD family protein
I6K22_15725	COG3133	Outer membrane lipoprotein
I6K22_15735	COG3895	Periplasmic Protein
I6K22_15755	COG0625	glutathione transferase activity
I6K22_15760	COG3104	oligopeptide transport
I6K22_15765	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
I6K22_15775	COG4659	FMN binding
I6K22_15815	COG0673	inositol 2-dehydrogenase activity
I6K22_15825	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
I6K22_15830	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6K22_15830	COG1263	PTS System
I6K22_15835	COG1609	Transcriptional regulator
I6K22_15840	COG1028	Short-chain dehydrogenase reductase Sdr
I6K22_15845	COG1309	transcriptional regulator
I6K22_15850	COG3250	beta-galactosidase activity
I6K22_15865	COG5339	Protein conserved in bacteria
I6K22_15870	COG1482	cell wall glycoprotein biosynthetic process
I6K22_15875	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
I6K22_15875	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
I6K22_15880	COG0114	fumarate hydratase activity
I6K22_15890	COG2205	protein histidine kinase activity
I6K22_15895	COG0745	RESPONSE REGULATOR receiver
I6K22_15900	COG3136	membrane protein required for alginate biosynthesis
I6K22_15910	COG0531	amino acid
I6K22_15920	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
I6K22_15925	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
I6K22_15930	COG0628	permease
I6K22_15945	COG3591	Belongs to the peptidase S1B family
I6K22_15960	COG2814	Major facilitator Superfamily
I6K22_15965	COG0583	DNA-binding transcription factor activity
I6K22_15970	COG1940	carbohydrate kinase activity
I6K22_15975	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
I6K22_15985	COG3381	protein complex oligomerization
I6K22_15990	COG3302	dmso reductase anchor subunit
I6K22_15995	COG0437	4 iron, 4 sulfur cluster binding
I6K22_16000	COG0243	molybdopterin cofactor binding
I6K22_16005	COG0243	molybdopterin cofactor binding
I6K22_16020	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6K22_16035	COG4948	Mandelate Racemase Muconate Lactonizing
I6K22_16040	COG1063	alcohol dehydrogenase
I6K22_16055	COG0246	Mannitol dehydrogenase
I6K22_16065	COG1802	Transcriptional regulator
I6K22_16070	COG4221	oxidoreductase activity
I6K22_16075	COG0339	signal peptide processing
I6K22_16080	COG3111	PFAM Bacterial OB fold (BOF) protein
I6K22_16085	COG3706	GGDEF domain
I6K22_16095	COG2814	Major facilitator Superfamily
I6K22_16100	COG0697	spore germination
I6K22_16105	COG2188	Transcriptional regulator
I6K22_16115	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
I6K22_16120	COG1447	Phosphotransferase system cellobiose-specific component IIA
I6K22_16130	COG2723	6-phospho-beta-galactosidase activity
I6K22_16140	COG4977	sequence-specific DNA binding
I6K22_16145	COG1846	Transcriptional regulator
I6K22_16165	COG0583	DNA-binding transcription factor activity
I6K22_16170	COG1012	belongs to the aldehyde dehydrogenase family
I6K22_16175	COG2066	Belongs to the glutaminase family
I6K22_16185	COG2199	diguanylate cyclase activity
I6K22_16195	COG3781	membrane
I6K22_16205	COG1396	sequence-specific DNA binding
I6K22_16210	COG3550	peptidyl-serine autophosphorylation
I6K22_16220	COG0702	epimerase
I6K22_16225	COG3539	Fimbrial protein
I6K22_16235	COG3188	usher protein
I6K22_16240	COG3539	Fimbrial protein
I6K22_16245	COG3539	Fimbrial protein
I6K22_16250	COG3539	Fimbrial protein
I6K22_16255	COG0243	molybdopterin cofactor binding
I6K22_16265	COG2207	Transcriptional regulator
I6K22_16270	COG3119	arylsulfatase activity
I6K22_16275	COG0641	radical SAM
I6K22_16285	COG4178	(ABC) transporter
I6K22_16290	COG4771	TonB-dependent receptor
I6K22_16295	COG0612	Peptidase, M16
I6K22_16300	COG0076	glutamate decarboxylase activity
I6K22_16305	COG0531	amino acid
I6K22_16310	COG1649	PFAM Uncharacterised BCR, COG1649
I6K22_16320	COG2200	EAL domain
I6K22_16320	COG2199	diguanylate cyclase activity
I6K22_16320	COG2202	Pas domain
I6K22_16325	COG1764	response to oxidative stress
I6K22_16345	COG1064	alcohol dehydrogenase
I6K22_16355	COG3093	addiction module antidote protein HigA
I6K22_16360	COG2864	formate dehydrogenase
I6K22_16365	COG0437	4 iron, 4 sulfur cluster binding
I6K22_16375	COG0697	spore germination
I6K22_16380	COG2223	nitrite transmembrane transporter activity
I6K22_16385	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
I6K22_16390	COG1140	nitrate reductase beta subunit
I6K22_16395	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
I6K22_16400	COG2181	nitrate reductase activity
I6K22_16405	COG0384	phenazine biosynthesis protein PhzF
I6K22_16410	COG2162	N-hydroxyarylamine O-acetyltransferase activity
I6K22_16415	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I6K22_16440	COG3501	Rhs element vgr protein
I6K22_16450	COG0625	glutathione transferase activity
I6K22_16455	COG0625	glutathione transferase activity
I6K22_16460	COG1113	amino acid transport
I6K22_16470	COG4772	TonB-dependent receptor
I6K22_16480	COG1247	-acetyltransferase
I6K22_16485	COG3238	Protein conserved in bacteria
I6K22_16510	COG1177	transmembrane transport
I6K22_16515	COG1176	ABC-type spermidine putrescine transport system, permease component I
I6K22_16520	COG3842	ATPase activity
I6K22_16525	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
I6K22_16530	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6K22_16545	COG0826	peptidase U32
I6K22_16550	COG1396	sequence-specific DNA binding
I6K22_16555	COG3135	benzoate transporter
I6K22_16565	COG0500	methyltransferase
I6K22_16570	COG1275	C4-dicarboxylate transporter malic acid transport protein
I6K22_16575	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
I6K22_16580	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6K22_16585	COG2841	Protein conserved in bacteria
I6K22_16595	COG5383	Protein conserved in bacteria
I6K22_16600	COG0583	DNA-binding transcription factor activity
I6K22_16620	COG3038	cytochrome b561
I6K22_16625	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
I6K22_16630	COG1012	belongs to the aldehyde dehydrogenase family
I6K22_16635	COG1434	Gram-negative-bacterium-type cell wall biogenesis
I6K22_16640	COG1643	Atp-dependent helicase
I6K22_16650	COG0671	phosphoesterase, PA-phosphatase related
I6K22_16650	COG2453	phosphatase
I6K22_16655	COG2267	carboxylic ester hydrolase activity
I6K22_16660	COG4589	Belongs to the CDS family
I6K22_16665	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
I6K22_16670	COG0667	Aldo Keto reductase
I6K22_16680	COG3784	Protein of unknown function (DUF1318)
I6K22_16690	COG2911	Protein conserved in bacteria
I6K22_16695	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I6K22_16700	COG3187	Heat shock protein
I6K22_16705	COG3042	response to heat
I6K22_16710	COG1013	pyruvate-flavodoxin oxidoreductase activity
I6K22_16710	COG0674	pyruvate-flavodoxin oxidoreductase activity
I6K22_16710	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
I6K22_16710	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6K22_16715	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
I6K22_16720	COG0589	response to stress
I6K22_16745	COG0513	Belongs to the DEAD box helicase family
I6K22_16755	COG3706	GGDEF domain
I6K22_16760	COG2840	Smr protein MutS2
I6K22_16775	COG2207	Transcriptional regulator
I6K22_16785	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I6K22_16790	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I6K22_16795	COG0589	response to stress
I6K22_16800	COG3182	Iron-regulated membrane protein
I6K22_16805	COG0668	transmembrane transport
I6K22_16810	COG4166	transmembrane transport
I6K22_16815	COG0583	DNA-binding transcription factor activity
I6K22_16820	COG1073	alpha beta
I6K22_16825	COG0702	epimerase
I6K22_16830	COG2866	Carboxypeptidase
I6K22_16835	COG4948	Mandelate Racemase Muconate Lactonizing
I6K22_16840	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
I6K22_16845	COG3283	Transcriptional regulator of aromatic amino acids metabolism
I6K22_16855	COG3106	COG3106 Predicted ATPase
I6K22_16860	COG1609	Transcriptional regulator
I6K22_16875	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6K22_16880	COG1554	hydrolase, family 65, central catalytic
I6K22_16885	COG0673	inositol 2-dehydrogenase activity
I6K22_16890	COG1082	Xylose isomerase domain protein TIM barrel
I6K22_16895	COG1063	alcohol dehydrogenase
I6K22_16900	COG0395	ABC-type sugar transport system, permease component
I6K22_16905	COG1175	transmembrane transport
I6K22_16910	COG1653	transport
I6K22_16915	COG0366	Alpha amylase catalytic
I6K22_16920	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I6K22_16930	COG1983	PspC domain protein
I6K22_16940	COG1842	Phage shock protein A
I6K22_16945	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
I6K22_16960	COG4166	transmembrane transport
I6K22_16965	COG4168	peptide transport system, permease
I6K22_16970	COG4171	peptide transport system, permease
I6K22_16975	COG4172	Belongs to the ABC transporter superfamily
I6K22_16980	COG4172	Belongs to the ABC transporter superfamily
I6K22_16985	COG2814	Major facilitator Superfamily
I6K22_16995	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6K22_17000	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6K22_17010	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
I6K22_17015	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I6K22_17015	COG4950	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I6K22_17030	COG5001	Diguanylate cyclase
I6K22_17040	COG1349	DNA-binding transcription factor activity
I6K22_17050	COG0023	Translation Initiation Factor
I6K22_17060	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
I6K22_17065	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
I6K22_17070	COG0671	phosphoesterase, PA-phosphatase related
I6K22_17080	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
I6K22_17100	COG0583	DNA-binding transcription factor activity
I6K22_17105	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I6K22_17115	COG0616	signal peptide processing
I6K22_17120	COG1028	Short-chain dehydrogenase reductase Sdr
I6K22_17125	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
I6K22_17130	COG1187	pseudouridine synthase activity
I6K22_17135	COG4907	membrane protein (DUF2207)
I6K22_17140	COG0009	L-threonylcarbamoyladenylate synthase
I6K22_17145	COG0613	PHP domain protein
I6K22_17155	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
I6K22_17160	COG0512	Glutamine amidotransferase of anthranilate synthase
I6K22_17160	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I6K22_17165	COG0134	indole-3-glycerol-phosphate synthase activity
I6K22_17165	COG0135	phosphoribosylanthranilate isomerase activity
I6K22_17180	COG3729	General stress protein
I6K22_17185	COG3685	Protein conserved in bacteria
I6K22_17190	COG3685	Protein conserved in bacteria
I6K22_17210	COG0500	methyltransferase
I6K22_17215	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
I6K22_17220	COG5301	cellulose 1,4-beta-cellobiosidase activity
I6K22_17330	COG4220	transposase activity
I6K22_17340	COG5562	phage envelope protein
I6K22_17350	COG3772	lysozyme
I6K22_17405	COG0484	heat shock protein binding
I6K22_17410	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
I6K22_17415	COG1403	HNH endonuclease
I6K22_17485	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I6K22_17495	COG0582	viral genome integration into host DNA
I6K22_17500	COG3047	cAMP biosynthetic process
I6K22_17520	COG1607	acyl-coa hydrolase
I6K22_17530	COG2350	Protein conserved in bacteria
I6K22_17535	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I6K22_17555	COG4608	Belongs to the ABC transporter superfamily
I6K22_17560	COG0444	Belongs to the ABC transporter superfamily
I6K22_17565	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6K22_17570	COG0601	transmembrane transport
I6K22_17575	COG4166	transmembrane transport
I6K22_17585	COG2095	MarC family integral membrane protein
I6K22_17590	COG1012	belongs to the aldehyde dehydrogenase family
I6K22_17590	COG1454	alcohol dehydrogenase
I6K22_17600	COG1435	thymidine kinase activity
I6K22_17610	COG1210	Utp--glucose-1-phosphate uridylyltransferase
I6K22_17615	COG0745	RESPONSE REGULATOR receiver
I6K22_17620	COG1752	Esterase of the alpha-beta hydrolase superfamily
I6K22_17630	COG0788	formyltetrahydrofolate deformylase activity
I6K22_17655	COG2181	nitrate reductase activity
I6K22_17660	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
I6K22_17665	COG1140	nitrate reductase beta subunit
I6K22_17670	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
I6K22_17675	COG2223	nitrite transmembrane transporter activity
I6K22_17680	COG3850	Histidine kinase
I6K22_17685	COG2197	response regulator
I6K22_17690	COG4932	domain protein
I6K22_17695	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
I6K22_17700	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
I6K22_17705	COG4572	Cation transport regulator
I6K22_17710	COG0387	Pfam Sodium calcium exchanger
I6K22_17725	COG2912	Transglutaminase-like superfamily
I6K22_17730	COG3094	Invasion gene expression up-regulator, SirB
I6K22_17735	COG2890	protein-(glutamine-N5) methyltransferase activity
I6K22_17760	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
I6K22_17765	COG0659	secondary active sulfate transmembrane transporter activity
I6K22_17780	COG0012	GTP binding
I6K22_17790	COG3284	Transcriptional regulator
I6K22_17795	COG2376	Dihydroxyacetone kinase
I6K22_17800	COG1461	Dihydroxyacetone kinase
I6K22_17805	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
I6K22_17805	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K22_17805	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I6K22_17815	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I6K22_17820	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6K22_17825	COG1120	ATPase activity
I6K22_17830	COG0500	methyltransferase
I6K22_17835	COG0157	Belongs to the NadC ModD family
I6K22_17850	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
I6K22_17860	COG1619	proteins homologs of microcin C7 resistance protein MccF
I6K22_17870	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
I6K22_17880	COG2719	SpoVR family
I6K22_17900	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I6K22_17905	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
I6K22_17920	COG0179	Fumarylacetoacetate (FAA) hydrolase
I6K22_17945	COG2894	cell division
I6K22_18020	COG2200	EAL domain
I6K22_18025	COG0789	Transcriptional regulator
I6K22_18030	COG5562	phage envelope protein
I6K22_18040	COG0538	isocitrate dehydrogenase activity
I6K22_18055	COG1121	(ABC) transporter
I6K22_18060	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I6K22_18065	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I6K22_18080	COG5301	cellulose 1,4-beta-cellobiosidase activity
I6K22_18110	COG1196	nuclear chromosome segregation
I6K22_18180	COG4220	transposase activity
I6K22_18205	COG3772	lysozyme
I6K22_18385	COG0582	viral genome integration into host DNA
I6K22_18390	COG0538	isocitrate dehydrogenase activity
I6K22_18395	COG1187	pseudouridine synthase activity
I6K22_18415	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
I6K22_18425	COG2205	protein histidine kinase activity
I6K22_18430	COG2850	peptidyl-arginine hydroxylation
I6K22_18450	COG1177	transmembrane transport
I6K22_18455	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
I6K22_18465	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
I6K22_18470	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
I6K22_18480	COG4591	ABC-type transport system involved in lipoprotein release permease component
I6K22_18490	COG4591	ABC-type transport system involved in lipoprotein release permease component
I6K22_18495	COG4763	Acyl-transferase
I6K22_18500	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
I6K22_18505	COG1388	LysM domain
I6K22_18505	COG1376	ErfK ybiS ycfS ynhG family protein
I6K22_18515	COG1309	transcriptional regulator
I6K22_18520	COG3134	Outer membrane lipoprotein
I6K22_18525	COG1252	NADH dehydrogenase
I6K22_18545	COG3417	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)
I6K22_18550	COG5633	Lipoprotein
I6K22_18555	COG0537	adenosine 5'-monophosphoramidase activity
I6K22_18560	COG4773	Receptor
I6K22_18565	COG1263	PTS System
I6K22_18565	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6K22_18570	COG0084	hydrolase, TatD family'
I6K22_18575	COG0470	DNA polymerase III
I6K22_18585	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
I6K22_18590	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I6K22_18595	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I6K22_18605	COG1028	Short-chain dehydrogenase reductase Sdr
I6K22_18610	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
I6K22_18630	COG1399	metal-binding, possibly nucleic acid-binding protein
I6K22_18635	COG0424	maF-like protein
I6K22_18640	COG0564	pseudouridine synthase activity
I6K22_18645	COG1530	ribonuclease E activity
I6K22_18650	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
I6K22_18655	COG1256	bacterial-type flagellum assembly
I6K22_18660	COG3951	Flagellar rod assembly protein muramidase FlgJ
I6K22_18660	COG1705	Flagellar rod assembly protein muramidase FlgJ
I6K22_18675	COG4786	Flagellar basal body rod
I6K22_18680	COG4787	bacterial-type flagellum-dependent cell motility
I6K22_18685	COG1749	Flagellar hook protein flgE
I6K22_18690	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
I6K22_18695	COG1558	bacterial-type flagellum-dependent cell motility
I6K22_18700	COG1815	bacterial-type flagellum-dependent cell motility
I6K22_18705	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
I6K22_18710	COG2747	anti-sigma28 factor FlgM
I6K22_18715	COG3418	PFAM FlgN family protein
I6K22_18720	COG0728	peptidoglycan biosynthetic process
I6K22_18725	COG0673	inositol 2-dehydrogenase activity
I6K22_18735	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6K22_18745	COG2999	glutathione oxidoreductase activity
I6K22_18780	COG3038	cytochrome b561
I6K22_18785	COG2353	YceI-like domain
I6K22_18795	COG1560	Kdo2-lipid A biosynthetic process
I6K22_18810	COG5645	(Lipo)protein
I6K22_18815	COG2943	transferase activity, transferring hexosyl groups
I6K22_18830	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6K22_18835	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
I6K22_18860	COG2197	response regulator
I6K22_18875	COG1462	curli production assembly transport component CsgG
I6K22_18885	COG3381	protein complex oligomerization
I6K22_18905	COG3706	GGDEF domain
I6K22_18910	COG0457	Tetratricopeptide repeat
I6K22_18915	COG1649	PFAM Uncharacterised BCR, COG1649
I6K22_18915	COG0726	polysaccharide deacetylase
I6K22_18920	COG1215	transferase activity, transferring glycosyl groups
I6K22_18925	COG3658	cytochrome
I6K22_18930	COG1702	phosphate starvation-inducible protein PhoH
I6K22_18950	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6K22_18960	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
I6K22_18960	COG0506	proline dehydrogenase activity
I6K22_18960	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
I6K22_18965	COG1309	transcriptional regulator
I6K22_19005	COG3729	General stress protein
I6K22_19040	COG0243	molybdopterin cofactor binding
I6K22_19045	COG3005	denitrification pathway
I6K22_19050	COG0745	RESPONSE REGULATOR receiver
I6K22_19055	COG1879	ABC-type sugar transport system periplasmic component
I6K22_19060	COG0784	Response regulator, receiver
I6K22_19060	COG2198	Histidine kinase
I6K22_19060	COG2205	protein histidine kinase activity
I6K22_19065	COG0348	domain, Protein
I6K22_19085	COG1278	Cold shock
I6K22_19090	COG1278	Cold shock
I6K22_19105	COG1294	oxidase, subunit
I6K22_19110	COG1271	oxidase subunit
I6K22_19115	COG1773	rubredoxin
I6K22_19120	COG1999	signal sequence binding
I6K22_19125	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
I6K22_19130	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
I6K22_19135	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
I6K22_19140	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
I6K22_19150	COG0670	Belongs to the BI1 family
I6K22_19155	COG2920	part of a sulfur-relay system
I6K22_19175	COG1832	CoA-binding protein
I6K22_19190	COG0210	DNA helicase
I6K22_19195	COG3304	Inner membrane component domain
I6K22_19200	COG1289	transmembrane transporter activity
I6K22_19205	COG3070	regulator of competence-specific genes
I6K22_19215	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
I6K22_19215	COG2885	chlorophyll binding
I6K22_19225	COG1067	ATP-dependent peptidase activity
I6K22_19235	COG3130	regulation of translation
I6K22_19240	COG3009	Protein conserved in bacteria
I6K22_19245	COG3008	intermembrane lipid transfer
I6K22_19245	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
I6K22_19250	COG2995	paraquat-inducible protein a
I6K22_19255	COG0488	(ABC) transporter
I6K22_19265	COG0633	Ferredoxin
I6K22_19265	COG3217	Mosc domain protein beta barrel domain protein
I6K22_19280	COG0431	NADPH-dependent FMN reductase
I6K22_19285	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6K22_19295	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6K22_19305	COG0308	aminopeptidase N
I6K22_19325	COG1448	Aminotransferase
I6K22_19330	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6K22_19335	COG3108	Peptidase M15
I6K22_19340	COG2989	Protein conserved in bacteria
I6K22_19350	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
I6K22_19360	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
I6K22_19365	COG1434	Gram-negative-bacterium-type cell wall biogenesis
I6K22_19370	COG3173	Aminoglycoside phosphotransferase
I6K22_19385	COG3214	Protein conserved in bacteria
I6K22_19400	COG2333	competence protein COMEC
I6K22_19400	COG0658	competence protein
I6K22_19410	COG0539	negative regulation of cytoplasmic translation
I6K22_19420	COG0501	Belongs to the peptidase M48B family
I6K22_19435	COG2323	membrane
I6K22_19440	COG1944	ATP diphosphatase activity
I6K22_19445	COG2116	formate transmembrane transporter activity
I6K22_19450	COG1882	Formate acetyltransferase
I6K22_19455	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
I6K22_19465	COG1335	isochorismatase
I6K22_19470	COG3302	dmso reductase anchor subunit
I6K22_19475	COG0437	4 iron, 4 sulfur cluster binding
I6K22_19480	COG0243	molybdopterin cofactor binding
I6K22_19490	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
I6K22_19500	COG1178	ABC-type Fe3 transport system permease component
I6K22_19500	COG1674	ftsk spoiiie
I6K22_19505	COG1522	sequence-specific DNA binding
I6K22_19510	COG0492	ferredoxin-NADP+ reductase activity
I6K22_19515	COG4988	ABC transporter
I6K22_19520	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
I6K22_19560	COG1203	CRISPR-associated helicase, Cas3
I6K22_19565	COG1518	maintenance of DNA repeat elements
I6K22_19570	COG0542	response to heat
I6K22_19580	COG1278	Cold shock
I6K22_19590	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6K22_19595	COG2990	Protein conserved in bacteria
I6K22_19600	COG3593	DNA synthesis involved in DNA repair
I6K22_19610	COG2431	L-lysine efflux transmembrane transporter activity
I6K22_19620	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6K22_19625	COG0028	Belongs to the TPP enzyme family
I6K22_19630	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
I6K22_19635	COG0702	epimerase
I6K22_19640	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6K22_19645	COG3023	N-Acetylmuramoyl-L-alanine amidase
I6K22_19660	COG1126	abc transporter atp-binding protein
I6K22_19665	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6K22_19670	COG4215	(ABC) transporter
I6K22_19675	COG4160	amino acid transport
I6K22_19680	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6K22_19695	COG1177	transmembrane transport
I6K22_19700	COG1176	ABC-type spermidine putrescine transport system, permease component I
I6K22_19705	COG3842	ATPase activity
I6K22_19710	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
I6K22_19725	COG0778	Nitroreductase
I6K22_19735	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
I6K22_19750	COG3226	Transcriptional regulator
I6K22_19755	COG0738	Major facilitator superfamily
I6K22_19760	COG0561	phosphatase activity
I6K22_19770	COG2814	Major facilitator Superfamily
I6K22_19775	COG0671	phosphoesterase, PA-phosphatase related
I6K22_19780	COG1349	DNA-binding transcription factor activity
I6K22_19785	COG1686	Belongs to the peptidase S11 family
I6K22_19790	COG0625	glutathione transferase activity
I6K22_19795	COG2133	pyrroloquinoline quinone binding
I6K22_19810	COG2199	diguanylate cyclase activity
I6K22_19815	COG2200	EAL domain
I6K22_19840	COG1446	asparaginase
I6K22_19845	COG0303	'Molybdopterin
I6K22_19850	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
I6K22_19855	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
I6K22_19860	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
I6K22_19865	COG1882	Formate acetyltransferase
I6K22_19870	COG0561	phosphatase activity
I6K22_19875	COG0488	(ABC) transporter
I6K22_19880	COG1376	ErfK ybiS ycfS ynhG family protein
I6K22_19885	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
I6K22_19890	COG1321	iron dependent repressor
I6K22_19900	COG2194	sulfuric ester hydrolase activity
I6K22_19905	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
I6K22_19915	COG5006	permease, DMT superfamily
I6K22_19925	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6K22_19930	COG0765	amino acid transport
I6K22_19935	COG1126	abc transporter atp-binding protein
I6K22_19940	COG0668	transmembrane transport
I6K22_19965	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
I6K22_19975	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
I6K22_19980	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I6K22_19985	COG1199	ATP-dependent helicase activity
I6K22_19995	COG0513	Belongs to the DEAD box helicase family
I6K22_20000	COG1309	transcriptional regulator
I6K22_20010	COG1131	(ABC) transporter
I6K22_20015	COG0842	Transport permease protein
I6K22_20020	COG0842	Transport permease protein
I6K22_20030	COG3568	Endonuclease Exonuclease Phosphatase
I6K22_20035	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6K22_20040	COG0392	lysyltransferase activity
I6K22_20045	COG0670	Belongs to the BI1 family
I6K22_20050	COG0670	Belongs to the BI1 family
I6K22_20055	COG0314	molybdopterin synthase activity
I6K22_20060	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
I6K22_20070	COG0521	Mo-molybdopterin cofactor biosynthetic process
I6K22_20080	COG0391	Required for morphogenesis under gluconeogenic growth conditions
I6K22_20090	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
I6K22_20095	COG2226	methyltransferase
I6K22_20110	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I6K22_20115	COG1881	PFAM PEBP family protein
I6K22_20120	COG4677	pectinesterase activity
I6K22_20125	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
I6K22_20135	COG2828	Protein conserved in bacteria
I6K22_20140	COG0583	DNA-binding transcription factor activity
I6K22_20150	COG0561	phosphatase activity
I6K22_20160	COG4149	molybdate abc transporter
I6K22_20165	COG0725	ABC transporter, periplasmic molybdate-binding protein
I6K22_20175	COG3585	molybdate ion transport
I6K22_20175	COG2005	Transcriptional regulator
I6K22_20180	COG1119	ATPase activity
I6K22_20185	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I6K22_20190	COG1085	galactose-1-phosphate uridylyltransferase
I6K22_20200	COG2017	converts alpha-aldose to the beta-anomer
I6K22_20210	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I6K22_20220	COG1230	cation diffusion facilitator family transporter
I6K22_20225	COG3201	nicotinamide mononucleotide transporter
I6K22_20270	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
I6K22_20275	COG2885	chlorophyll binding
I6K22_20285	COG3064	Membrane
I6K22_20290	COG0848	biopolymer transport protein
I6K22_20295	COG0811	peptide transport
I6K22_20300	COG0824	Thioesterase
I6K22_20305	COG3790	cyd operon protein YbgE
I6K22_20310	COG4890	Cyd operon protein YbgT
I6K22_20315	COG1294	oxidase, subunit
I6K22_20320	COG1271	oxidase subunit
I6K22_20330	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
I6K22_20340	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6K22_20345	COG0567	Dehydrogenase, E1 component
I6K22_20350	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
I6K22_20355	COG1053	succinate dehydrogenase
I6K22_20360	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
I6K22_20365	COG2009	succinate dehydrogenase
I6K22_20375	COG0372	Belongs to the citrate synthase family
I6K22_20380	COG3539	Fimbrial protein
I6K22_20385	COG3180	Ammonia monooxygenase
I6K22_20400	COG1984	allophanate hydrolase subunit 2
I6K22_20405	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
I6K22_20410	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
I6K22_20420	COG0415	Belongs to the DNA photolyase family
I6K22_20425	COG3272	Protein of unknown function (DUF1722)
I6K22_20455	COG2205	protein histidine kinase activity
I6K22_20460	COG0745	RESPONSE REGULATOR receiver
I6K22_20470	COG1982	Orn Lys Arg decarboxylase major
I6K22_20475	COG0531	amino acid
I6K22_20480	COG0033	Phosphoglucomutase
I6K22_20485	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
I6K22_20490	COG0596	Alpha beta hydrolase
I6K22_20500	COG0716	FMN binding
I6K22_20510	COG0735	belongs to the Fur family
I6K22_20530	COG1349	DNA-binding transcription factor activity
I6K22_20535	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
I6K22_20540	COG3395	kinase activity
I6K22_20545	COG1454	alcohol dehydrogenase
I6K22_20550	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6K22_20575	COG1263	PTS System
I6K22_20575	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6K22_20575	COG2190	(PTS) system
I6K22_20585	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
I6K22_20590	COG1940	carbohydrate kinase activity
I6K22_20590	COG1846	Transcriptional regulator
I6K22_20595	COG0647	UMP catabolic process
I6K22_20600	COG0367	asparagine synthase
I6K22_20640	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6K22_20650	COG1702	phosphate starvation-inducible protein PhoH
I6K22_20660	COG4535	Mg2 and Co2 transporter CorC
I6K22_20665	COG0815	Transfers the fatty acyl group on membrane lipoproteins
I6K22_20675	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6K22_20680	COG0765	amino acid transport
I6K22_20685	COG0765	amino acid transport
I6K22_20690	COG1126	abc transporter atp-binding protein
I6K22_20700	COG2888	peptidyl-tyrosine sulfation
I6K22_20715	COG1466	dna polymerase III delta subunit
I6K22_20725	COG0406	alpha-ribazole phosphatase activity
I6K22_20730	COG0799	negative regulation of ribosome biogenesis
I6K22_20740	COG0768	penicillin binding
I6K22_20745	COG0772	Belongs to the SEDS family
I6K22_20750	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
I6K22_20755	COG1686	Belongs to the peptidase S11 family
I6K22_20775	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I6K22_20780	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I6K22_20800	COG3069	C4-dicarboxylate transmembrane transporter activity
I6K22_20805	COG4565	transcriptional regulatory protein
I6K22_20810	COG3290	protein histidine kinase activity
I6K22_20815	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
I6K22_20825	COG2301	Belongs to the HpcH HpaI aldolase family
I6K22_20830	COG3051	citrate lyase alpha subunit
I6K22_20845	COG0471	metal ion transport
I6K22_20850	COG3719	Belongs to the RNase T2 family
I6K22_20855	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I6K22_20860	COG0589	response to stress
I6K22_20865	COG3634	alkyl hydroperoxide reductase activity
I6K22_20870	COG0450	alkyl hydroperoxide reductase
I6K22_20875	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I6K22_20880	COG0583	DNA-binding transcription factor activity
I6K22_20885	COG3969	phosphoadenosine phosphosulfate
I6K22_20890	COG1475	DNA binding
I6K22_20895	COG0436	Aminotransferase
I6K22_20900	COG0371	Dehydrogenase
I6K22_20905	COG2879	small protein
I6K22_20910	COG1966	Carbon starvation protein
I6K22_20915	COG2050	protein possibly involved in aromatic compounds catabolism
I6K22_20920	COG1028	Short-chain dehydrogenase reductase Sdr
I6K22_20925	COG1535	isochorismatase
I6K22_20925	COG3433	isochorismatase activity
I6K22_20930	COG1021	2,3-dihydroxybenzoate-AMP ligase
I6K22_20935	COG1169	isochorismate synthase
I6K22_20940	COG4592	Periplasmic binding protein
I6K22_20950	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6K22_20955	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6K22_20960	COG1120	ATPase activity
I6K22_20965	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
I6K22_20970	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I6K22_20970	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
I6K22_20975	COG3251	PFAM MbtH domain protein
I6K22_20980	COG2382	esterase
I6K22_20990	COG4771	TonB-dependent receptor
I6K22_20995	COG2977	Belongs to the P-Pant transferase superfamily
I6K22_21015	COG2315	Protein conserved in bacteria
I6K22_21020	COG0778	Nitroreductase
I6K22_21025	COG0668	transmembrane transport
I6K22_21030	COG1113	amino acid transport
I6K22_21035	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6K22_21040	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6K22_21045	COG5569	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6K22_21050	COG1538	Outer membrane efflux protein
I6K22_21055	COG0745	RESPONSE REGULATOR receiver
I6K22_21060	COG5002	protein histidine kinase activity
I6K22_21065	COG1215	transferase activity, transferring glycosyl groups
I6K22_21070	COG4783	chaperone-mediated protein folding
I6K22_21080	COG4571	Outer membrane protease
I6K22_21085	COG0500	methyltransferase
I6K22_21110	COG2501	S4 domain
I6K22_21115	COG1988	membrane-bound metal-dependent
I6K22_21125	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
I6K22_21140	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
I6K22_21145	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
I6K22_21150	COG0549	Belongs to the carbamate kinase family
I6K22_21160	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
I6K22_21165	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
I6K22_21170	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
I6K22_21175	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I6K22_21180	COG3257	ureidoglycine aminohydrolase activity
I6K22_21185	COG1929	Belongs to the glycerate kinase type-1 family
I6K22_21190	COG2233	PERMEase
I6K22_21200	COG1953	Uracil, thiamine, allantoin
I6K22_21205	COG2084	Dehydrogenase
I6K22_21210	COG3622	Belongs to the hyi family
I6K22_21215	COG3960	tartronate-semialdehyde synthase activity
I6K22_21240	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
I6K22_21245	COG4181	ATPase activity
I6K22_21250	COG2755	lipolytic protein G-D-S-L family
I6K22_21255	COG0300	oxidoreductase activity
I6K22_21260	COG3118	belongs to the thioredoxin family
I6K22_21265	COG0390	transport system, permease component
I6K22_21270	COG4619	ABC transporter
I6K22_21275	COG0330	HflC and HflK could
I6K22_21280	COG1585	Membrane protein implicated in regulation of membrane protease activity
I6K22_21305	COG0789	Transcriptional regulator
I6K22_21310	COG0531	amino acid
I6K22_21315	COG2066	Belongs to the glutaminase family
I6K22_21320	COG2217	Heavy metal translocating P-type atpase
I6K22_21325	COG3093	addiction module antidote protein HigA
I6K22_21330	COG3549	Plasmid maintenance system killer
I6K22_21335	COG3735	TraB family
I6K22_21340	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
I6K22_21355	COG0737	Belongs to the 5'-nucleotidase family
I6K22_21360	COG2223	nitrite transmembrane transporter activity
I6K22_21365	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I6K22_21365	COG4651	solute:proton antiporter activity
I6K22_21370	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6K22_21405	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
I6K22_21415	COG2832	Protein of unknown function (DUF454)
I6K22_21420	COG3923	Primosomal replication protein n
I6K22_21430	COG3264	Mechanosensitive ion channel
I6K22_21430	COG1196	nuclear chromosome segregation
I6K22_21435	COG1309	transcriptional regulator
I6K22_21440	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6K22_21445	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6K22_21460	COG0110	maltose O-acetyltransferase activity
I6K22_21470	COG4943	cyclic-guanylate-specific phosphodiesterase activity
I6K22_21475	COG5507	3-demethylubiquinone-9 3-methyltransferase
I6K22_21485	COG3695	enzyme binding
I6K22_21490	COG3126	Type III secretion system lipoprotein chaperone (YscW)
I6K22_21495	COG1946	Acyl-CoA thioesterase
I6K22_21500	COG0004	ammonium transporteR
I6K22_21505	COG0347	Belongs to the P(II) protein family
I6K22_21510	COG1132	(ABC) transporter
I6K22_21515	COG1132	(ABC) transporter
I6K22_21520	COG1522	sequence-specific DNA binding
I6K22_21530	COG4533	DNA binding
I6K22_21540	COG0824	Thioesterase
I6K22_21545	COG1555	photosystem II stabilization
I6K22_21550	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6K22_21555	COG0776	regulation of translation
I6K22_21560	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
I6K22_21580	COG0271	Belongs to the BolA IbaG family
I6K22_21585	COG3056	Lipoprotein
I6K22_21590	COG2223	nitrite transmembrane transporter activity
I6K22_21595	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
I6K22_21600	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
I6K22_21605	COG1845	cytochrome c oxidase, subunit III
I6K22_21610	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
I6K22_21620	COG2814	Major facilitator Superfamily
I6K22_21630	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
I6K22_21635	COG0693	protein deglycase activity
I6K22_21650	COG0142	geranyltranstransferase activity
I6K22_21660	COG0667	Aldo Keto reductase
I6K22_21665	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
I6K22_21670	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
I6K22_21685	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I6K22_21685	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I6K22_21695	COG4238	major outer membrane lipoprotein
I6K22_21700	COG3248	Nucleoside-binding outer membrane protein
I6K22_21705	COG1403	HNH endonuclease
I6K22_21710	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I6K22_21715	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I6K22_21720	COG1862	Preprotein translocase
I6K22_21740	COG0366	Alpha amylase catalytic
I6K22_21745	COG1113	amino acid transport
I6K22_21750	COG1114	Component of the transport system for branched-chain amino acids
I6K22_21755	COG5002	protein histidine kinase activity
I6K22_21760	COG0745	RESPONSE REGULATOR receiver
I6K22_21765	COG0420	3'-5' exonuclease activity
I6K22_21770	COG0419	ATPase involved in DNA repair
I6K22_21775	COG2814	Major facilitator Superfamily
I6K22_21780	COG1940	carbohydrate kinase activity
I6K22_21805	COG4126	flavin adenine dinucleotide binding
I6K22_21825	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
I6K22_21830	COG3706	GGDEF domain
I6K22_21840	COG1785	Belongs to the alkaline phosphatase family
I6K22_21855	COG1181	Belongs to the D-alanine--D-alanine ligase family
I6K22_21875	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
I6K22_21880	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I6K22_21885	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I6K22_21890	COG3468	outer membrane autotransporter barrel domain protein
I6K22_21895	COG0113	porphobilinogen synthase activity
I6K22_21900	COG2175	clavaminate synthase activity
I6K22_21905	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6K22_21915	COG4521	taurine ABC transporter
I6K22_21920	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
I6K22_21925	COG1215	transferase activity, transferring glycosyl groups
I6K22_21955	COG3122	Protein conserved in bacteria
I6K22_21965	COG1609	Transcriptional regulator
I6K22_21975	COG2223	nitrite transmembrane transporter activity
I6K22_21980	COG0110	maltose O-acetyltransferase activity
I6K22_21985	COG0402	S-adenosylhomocysteine deaminase activity
I6K22_21990	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
I6K22_21995	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
I6K22_22000	COG2079	MmgE PrpD family protein
I6K22_22005	COG0372	Belongs to the citrate synthase family
I6K22_22010	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
I6K22_22025	COG1280	lysine exporter protein (LysE YggA)
I6K22_22035	COG1064	alcohol dehydrogenase
I6K22_22045	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6K22_22050	COG1129	ABC transporter
I6K22_22055	COG1879	ABC-type sugar transport system periplasmic component
I6K22_22065	COG0402	S-adenosylhomocysteine deaminase activity
I6K22_22070	COG0549	Belongs to the carbamate kinase family
I6K22_22075	COG1304	FMN binding
I6K22_22080	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
I6K22_22090	COG0666	response to abiotic stimulus
I6K22_22100	COG0583	DNA-binding transcription factor activity
I6K22_22105	COG2771	luxR family
I6K22_22105	COG2200	EAL domain
I6K22_22110	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I6K22_22130	COG0582	viral genome integration into host DNA
I6K22_22135	COG2200	EAL domain
I6K22_22135	COG2771	luxR family
I6K22_22150	COG3468	outer membrane autotransporter barrel domain protein
I6K22_22160	COG1556	Lactate utilization protein
I6K22_22165	COG1139	Iron-sulfur cluster binding protein
I6K22_22170	COG0247	lactate metabolic process
I6K22_22175	COG2207	Transcriptional regulator
I6K22_22180	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6K22_22190	COG3059	membrane
I6K22_22200	COG2207	Transcriptional regulator
I6K22_22200	COG3708	Transcriptional regulator
I6K22_22205	COG1388	LysM domain
I6K22_22210	COG0656	L-ascorbic acid biosynthetic process
I6K22_22215	COG0667	Aldo Keto reductase
I6K22_22225	COG0583	DNA-binding transcription factor activity
I6K22_22230	COG1073	alpha beta
I6K22_22235	COG1902	pentaerythritol trinitrate reductase activity
I6K22_22290	COG0727	PFAM Uncharacterised protein family (UPF0153)
I6K22_22300	COG3477	response to acidic pH
I6K22_22330	COG0582	viral genome integration into host DNA
I6K22_22350	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
I6K22_22370	COG2195	Cleaves the N-terminal amino acid of tripeptides
I6K22_22375	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
I6K22_22380	COG1690	Belongs to the RtcB family
I6K22_22385	COG0454	-acetyltransferase
I6K22_22395	COG2161	toxin-antitoxin pair type II binding
I6K22_22420	COG1943	Transposase
I6K22_22425	COG0791	NLP P60 protein
I6K22_22430	COG3034	peptidoglycan biosynthetic process
I6K22_22435	COG0121	glutamine amidotransferase
I6K22_22445	COG1960	acyl-CoA dehydrogenase activity
I6K22_22455	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I6K22_22495	COG3501	Rhs element vgr protein
I6K22_22590	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I6K22_22600	COG2226	methyltransferase
I6K22_22610	COG0741	lytic transglycosylase activity
I6K22_22610	COG1388	LysM domain
I6K22_22615	COG2226	methyltransferase
I6K22_22625	COG0583	DNA-binding transcription factor activity
I6K22_22630	COG0656	L-ascorbic acid biosynthetic process
I6K22_22665	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
I6K22_22670	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
I6K22_22675	COG2011	ABC-type metal ion transport system permease component
I6K22_22680	COG1464	Belongs to the NlpA lipoprotein family
I6K22_22690	COG1720	tRNA m6t6A37 methyltransferase activity
I6K22_22700	COG0791	NLP P60 protein
I6K22_22705	COG3015	lipoprotein NlpE involved in copper resistance
I6K22_22710	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
I6K22_22715	COG4681	YaeQ
I6K22_22725	COG4568	rho-dependent transcription termination
I6K22_22730	COG0037	tRNA processing
I6K22_22735	COG0346	lactoylglutathione lyase activity
I6K22_22740	COG1982	Orn Lys Arg decarboxylase major
I6K22_22750	COG0587	DNA-directed DNA polymerase activity
I6K22_22780	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
I6K22_22790	COG0750	zinc metalloprotease
I6K22_22795	COG0575	Belongs to the CDS family
I6K22_22800	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
I6K22_22805	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
I6K22_22830	COG0024	Methionine aminopeptidase
I6K22_22850	COG3835	regulator
I6K22_22855	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6K22_22870	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I6K22_22875	COG2860	membrane
I6K22_22900	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6K22_22905	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I6K22_22910	COG1120	ATPase activity
I6K22_22915	COG4774	siderophore transport
I6K22_22920	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I6K22_22925	COG1643	Atp-dependent helicase
I6K22_22930	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
I6K22_22940	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
I6K22_22945	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
I6K22_22950	COG0617	tRNA 3'-terminal CCA addition
I6K22_22955	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
I6K22_22960	COG3539	Fimbrial protein
I6K22_22965	COG3121	Chaperone
I6K22_22970	COG3188	usher protein
I6K22_22975	COG3539	Fimbrial protein
I6K22_22980	COG3539	Fimbrial protein
I6K22_22985	COG3539	Fimbrial protein
I6K22_22990	COG3539	Fimbrial protein
I6K22_23005	COG5464	transposase or invertase
I6K22_23015	COG0726	polysaccharide deacetylase
I6K22_23020	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6K22_23025	COG0842	Transport permease protein
I6K22_23030	COG1131	(ABC) transporter
I6K22_23035	COG0288	reversible hydration of carbon dioxide
I6K22_23040	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
I6K22_23045	COG4993	Dehydrogenase
I6K22_23050	COG2132	Multicopper oxidase
I6K22_23075	COG1049	propionate catabolic process, 2-methylcitrate cycle
I6K22_23080	COG3064	Membrane
I6K22_23085	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6K22_23090	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6K22_23095	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
I6K22_23100	COG2186	Transcriptional regulator
I6K22_23130	COG3157	Type VI secretion system effector, Hcp
I6K22_23135	COG1113	amino acid transport
I6K22_23140	COG3725	Membrane protein required for beta-lactamase induction
I6K22_23145	COG3023	N-Acetylmuramoyl-L-alanine amidase
I6K22_23150	COG0157	Belongs to the NadC ModD family
I6K22_23155	COG4969	Belongs to the N-Me-Phe pilin family
I6K22_23160	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I6K22_23165	COG1459	type II secretion system
I6K22_23180	COG0237	dephospho-CoA kinase activity
I6K22_23195	COG0494	nUDIX hydrolase
I6K22_23215	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
I6K22_23220	COG0849	cell division
I6K22_23225	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
I6K22_23230	COG1181	Belongs to the D-alanine--D-alanine ligase family
I6K22_23245	COG0772	Belongs to the SEDS family
I6K22_23260	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
I6K22_23265	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
I6K22_23270	COG0768	penicillin binding
I6K22_23275	COG3116	cell division
I6K22_23290	COG1609	Transcriptional regulator
I6K22_23300	COG0440	acetolactate synthase activity
I6K22_23305	COG0028	Belongs to the TPP enzyme family
I6K22_23315	COG0583	DNA-binding transcription factor activity
I6K22_23355	COG4143	(ABC) transporter
I6K22_23360	COG1178	ABC-type Fe3 transport system permease component
I6K22_23370	COG0586	Pfam SNARE associated Golgi protein
I6K22_23385	COG4977	sequence-specific DNA binding
I6K22_23400	COG0235	Class ii aldolase
I6K22_23405	COG0417	DNA replication proofreading
I6K22_23415	COG0564	pseudouridine synthase activity
I6K22_23420	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
I6K22_23430	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6K22_23435	COG1995	Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP)
I6K22_23470	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
I6K22_23485	COG2271	Major facilitator Superfamily
I6K22_23490	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
I6K22_23495	COG0644	oxidoreductase
I6K22_23550	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
I6K22_23555	COG0505	Belongs to the CarA family
I6K22_23580	COG1047	Peptidyl-prolyl cis-trans
I6K22_23595	COG0196	riboflavin kinase activity
I6K22_23610	COG0583	DNA-binding transcription factor activity
I6K22_23625	COG3119	arylsulfatase activity
I6K22_23655	COG4735	regulation of single-species biofilm formation
I6K22_23660	COG1584	GPR1 FUN34 yaaH family protein
I6K22_23665	COG0521	Mo-molybdopterin cofactor biosynthetic process
I6K22_23675	COG1115	amino acid carrier protein
I6K22_23690	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
I6K22_23700	COG0460	homoserine dehydrogenase
I6K22_23700	COG0527	aspartate kinase activity
I6K22_23710	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
I6K22_23720	COG0745	RESPONSE REGULATOR receiver
I6K22_23725	COG4452	Inner membrane protein CreD
I6K22_23730	COG2205	protein histidine kinase activity
I6K22_23735	COG0745	RESPONSE REGULATOR receiver
I6K22_23740	COG3045	CreA protein
I6K22_23745	COG2207	Transcriptional regulator
I6K22_23745	COG3708	Transcriptional regulator
I6K22_23765	COG0741	lytic transglycosylase activity
I6K22_23770	COG0488	(ABC) transporter
I6K22_23775	COG3172	ATPase kinase involved in NAD metabolism
I6K22_23775	COG1056	cytidyltransferase-related domain
I6K22_23780	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
I6K22_23785	COG0560	Phosphoserine phosphatase
I6K22_23790	COG3726	membrane protein affecting hemolysin expression
I6K22_23825	COG1328	CTP reductase activity
I6K22_23830	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
I6K22_23835	COG0084	hydrolase, TatD family'
I6K22_23840	COG4667	esterase of the alpha-beta hydrolase superfamily
I6K22_23850	COG2823	Periplasmic or secreted lipoprotein
I6K22_23860	COG1011	Hydrolase
I6K22_23865	COG0456	acetyltransferase
I6K22_23870	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
I6K22_23900	COG4114	ferric iron reductase
I6K22_23905	COG2197	response regulator
I6K22_23910	COG2197	response regulator
I6K22_23915	COG2966	Psort location CytoplasmicMembrane, score
I6K22_23930	COG1484	DNA-dependent DNA replication
I6K22_23975	COG1484	DNA-dependent DNA replication
I6K22_23980	COG4584	PFAM Integrase catalytic
I6K22_24015	COG0577	efflux transmembrane transporter activity
I6K22_24015	COG1136	(ABC) transporter
I6K22_24020	COG1136	(ABC) transporter
I6K22_24020	COG0577	efflux transmembrane transporter activity
I6K22_24025	COG1136	(ABC) transporter
I6K22_24025	COG0577	efflux transmembrane transporter activity
I6K22_24040	COG0672	)-iron permease
I6K22_24045	COG2869	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol
I6K22_24050	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6K22_24330	COG1475	DNA binding
I6K22_24530	COG4771	TonB-dependent receptor
I6K22_24560	COG3436	PFAM IS66 Orf2 family protein
I6K22_24575	COG3344	reverse transcriptase