locus-tag	class	description
I6G98_00030	COG3109	RNA chaperone with significant RNA binding, RNA strand exchange and RNA duplexing activities
I6G98_00080	COG2990	Protein conserved in bacteria
I6G98_00085	COG0297	glycogen (starch) synthase activity
I6G98_00090	COG0726	polysaccharide deacetylase
I6G98_00285	COG3436	PFAM IS66 Orf2 family protein
I6G98_00410	COG1475	DNA binding
I6G98_00415	COG3969	phosphoadenosine phosphosulfate
I6G98_00465	COG3547	Transposase (IS116 IS110 IS902 family)
I6G98_00475	COG3436	PFAM IS66 Orf2 family protein
I6G98_00510	COG0583	DNA-binding transcription factor activity
I6G98_00575	COG3657	addiction module killer protein
I6G98_00655	COG2373	Large extracellular alpha-helical protein
I6G98_00655	COG4932	domain protein
I6G98_00655	COG1388	LysM domain
I6G98_00700	COG1662	PFAM IS1 transposase
I6G98_00770	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
I6G98_00775	COG1403	HNH endonuclease
I6G98_00845	COG3646	Phage regulatory protein
I6G98_00860	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I6G98_00915	COG1276	copper resistance
I6G98_00920	COG2372	response to copper ion
I6G98_00930	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I6G98_00940	COG1770	oligopeptidase
I6G98_00945	COG2979	Protein of unknown function (DUF533)
I6G98_00955	COG3141	response to X-ray
I6G98_00965	COG0800	Aldolase
I6G98_00970	COG0129	dihydroxy-acid dehydratase activity
I6G98_00975	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
I6G98_00980	COG1737	Transcriptional regulator
I6G98_00985	COG0469	pyruvate kinase activity
I6G98_00990	COG1560	Kdo2-lipid A biosynthetic process
I6G98_00995	COG0739	heme binding
I6G98_01000	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
I6G98_01010	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I6G98_01045	COG0217	transcriptional regulatory protein
I6G98_01050	COG0494	nUDIX hydrolase
I6G98_01060	COG1335	isochorismatase
I6G98_01085	COG5301	cellulose 1,4-beta-cellobiosidase activity
I6G98_01185	COG3772	lysozyme
I6G98_01225	COG0484	heat shock protein binding
I6G98_01230	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
I6G98_01240	COG0305	Participates in initiation and elongation during chromosome replication
I6G98_01245	COG1484	DNA-dependent DNA replication
I6G98_01260	COG3646	Phage regulatory protein
I6G98_01290	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
I6G98_01365	COG0582	viral genome integration into host DNA
I6G98_01370	COG1801	Protein of unknown function DUF72
I6G98_01375	COG3788	relative of glutathione S-transferase, MAPEG superfamily
I6G98_01390	COG0243	molybdopterin cofactor binding
I6G98_01395	COG3005	denitrification pathway
I6G98_01405	COG3102	Protein conserved in bacteria
I6G98_01415	COG3755	Protein conserved in bacteria
I6G98_01425	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
I6G98_01465	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
I6G98_01470	COG0745	RESPONSE REGULATOR receiver
I6G98_01475	COG2201	protein-glutamate methylesterase activity
I6G98_01480	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
I6G98_01485	COG0840	transmembrane signaling receptor activity
I6G98_01490	COG0840	transmembrane signaling receptor activity
I6G98_01495	COG0835	chemotaxis
I6G98_01500	COG2198	Histidine kinase
I6G98_01500	COG0643	Histidine kinase
I6G98_01505	COG1360	Flagellar Motor Protein
I6G98_01510	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
I6G98_01530	COG0589	response to stress
I6G98_01540	COG1877	trehalose-phosphatase activity
I6G98_01545	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6G98_01550	COG1129	ABC transporter
I6G98_01555	COG1879	ABC-type sugar transport system periplasmic component
I6G98_01560	COG1528	Iron-storage protein
I6G98_01585	COG1528	Iron-storage protein
I6G98_01595	COG0814	amino acid
I6G98_01600	COG3318	Belongs to the UPF0149 family
I6G98_01600	COG3012	SEC-C Motif Domain Protein
I6G98_01605	COG4974	Belongs to the 'phage' integrase family
I6G98_01690	COG4695	Portal protein
I6G98_01775	COG5301	cellulose 1,4-beta-cellobiosidase activity
I6G98_01800	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
I6G98_01885	COG2197	response regulator
I6G98_01900	COG2197	response regulator
I6G98_01905	COG1126	abc transporter atp-binding protein
I6G98_01910	COG0765	amino acid transport
I6G98_01920	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6G98_01930	COG1191	sigma factor activity
I6G98_01940	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
I6G98_01945	COG1516	flagellar protein fliS
I6G98_01955	COG0366	Alpha amylase catalytic
I6G98_01965	COG2391	methyltransferase activity
I6G98_01970	COG0425	Belongs to the sulfur carrier protein TusA family
I6G98_01975	COG2135	peptidase activity
I6G98_01980	COG0675	Transposase, IS605 OrfB family
I6G98_01990	COG2207	Transcriptional regulator
I6G98_01995	COG1881	PFAM PEBP family protein
I6G98_02000	COG2076	Multidrug Resistance protein
I6G98_02015	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
I6G98_02020	COG1317	bacterial-type flagellum organization
I6G98_02025	COG1157	protein secretion by the type III secretion system
I6G98_02030	COG2882	bacterial-type flagellum organization
I6G98_02035	COG3144	bacterial-type flagellum assembly
I6G98_02040	COG1580	Controls the rotational direction of flagella during chemotaxis
I6G98_02045	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
I6G98_02050	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
I6G98_02055	COG3190	flagellar
I6G98_02060	COG1338	Plays a role in the flagellum-specific transport system
I6G98_02065	COG1987	bacterial-type flagellum assembly
I6G98_02095	COG2197	response regulator
I6G98_02115	COG3706	GGDEF domain
I6G98_02120	COG5475	Uncharacterized small protein (DUF2158)
I6G98_02125	COG2354	Protein conserved in bacteria
I6G98_02130	COG0697	spore germination
I6G98_02135	COG3727	T/G mismatch-specific endonuclease activity
I6G98_02140	COG0270	DNA (cytosine-5-)-methyltransferase activity
I6G98_02145	COG1418	mRNA catabolic process
I6G98_02170	COG2205	protein histidine kinase activity
I6G98_02175	COG0745	RESPONSE REGULATOR receiver
I6G98_02180	COG2351	hydroxyisourate hydrolase activity
I6G98_02195	COG3443	Belongs to the bacterial solute-binding protein 9 family
I6G98_02200	COG3038	cytochrome b561
I6G98_02235	COG0477	Major facilitator Superfamily
I6G98_02245	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
I6G98_02250	COG0217	transcriptional regulatory protein
I6G98_02260	COG0534	Mate efflux family protein
I6G98_02270	COG0582	viral genome integration into host DNA
I6G98_02300	COG0583	DNA-binding transcription factor activity
I6G98_02305	COG0583	DNA-binding transcription factor activity
I6G98_02315	COG1376	ErfK ybiS ycfS ynhG family protein
I6G98_02330	COG2087	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate
I6G98_02400	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
I6G98_02415	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
I6G98_02430	COG1454	alcohol dehydrogenase
I6G98_02430	COG1012	belongs to the aldehyde dehydrogenase family
I6G98_02435	COG4656	Part of a membrane complex involved in electron transport
I6G98_02460	COG1289	transmembrane transporter activity
I6G98_02470	COG1686	Belongs to the peptidase S11 family
I6G98_02475	COG2925	Exonuclease
I6G98_02480	COG0425	Belongs to the sulfur carrier protein TusA family
I6G98_02485	COG2391	methyltransferase activity
I6G98_02490	COG0531	amino acid
I6G98_02500	COG0583	DNA-binding transcription factor activity
I6G98_02505	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6G98_02530	COG0131	Imidazoleglycerol-phosphate dehydratase
I6G98_02530	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
I6G98_02535	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
I6G98_02540	COG0106	1-(5-phosphoribosyl)-5- 5-phosphoribosylamino)methylideneamino imidazole-4-carboxamide isomerase
I6G98_02565	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
I6G98_02580	COG1215	transferase activity, transferring glycosyl groups
I6G98_02585	COG1216	Glycosyl transferase, family 2
I6G98_02605	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
I6G98_02610	COG1210	Utp--glucose-1-phosphate uridylyltransferase
I6G98_02620	COG0438	transferase activity, transferring glycosyl groups
I6G98_02640	COG2244	polysaccharide biosynthetic process
I6G98_02645	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
I6G98_02650	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
I6G98_02660	COG0297	glycogen (starch) synthase activity
I6G98_02665	COG1051	belongs to the nudix hydrolase family
I6G98_02670	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6G98_02675	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
I6G98_02680	COG0110	maltose O-acetyltransferase activity
I6G98_02685	COG1216	Glycosyl transferase, family 2
I6G98_02695	COG0438	transferase activity, transferring glycosyl groups
I6G98_02700	COG1045	serine acetyltransferase
I6G98_02705	COG0463	Glycosyl transferase, family 2
I6G98_02710	COG3206	protein involved in exopolysaccharide biosynthesis
I6G98_02710	COG0489	protein tyrosine kinase activity
I6G98_02715	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I6G98_02720	COG1596	polysaccharide export
I6G98_02730	COG1253	flavin adenine dinucleotide binding
I6G98_02735	COG2982	Protein involved in outer membrane biogenesis
I6G98_02745	COG0572	uridine kinase
I6G98_02755	COG3547	Transposase (IS116 IS110 IS902 family)
I6G98_02765	COG3447	MASE1 domain protein
I6G98_02765	COG5001	Diguanylate cyclase
I6G98_02765	COG5002	protein histidine kinase activity
I6G98_02770	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
I6G98_02775	COG0443	Heat shock 70 kDa protein
I6G98_02785	COG0631	protein serine/threonine phosphatase activity
I6G98_02790	COG4245	von Willebrand factor, type A
I6G98_02830	COG2205	protein histidine kinase activity
I6G98_02835	COG0745	RESPONSE REGULATOR receiver
I6G98_02845	COG3609	addiction module antidote protein, CC2985 family
I6G98_02855	COG0826	peptidase U32
I6G98_02915	COG5301	cellulose 1,4-beta-cellobiosidase activity
I6G98_02915	COG5301	cellulose 1,4-beta-cellobiosidase activity
I6G98_03005	COG4695	Portal protein
I6G98_03095	COG2211	Major facilitator Superfamily
I6G98_03100	COG1830	Aldolase
I6G98_03120	COG3775	system Galactitol-specific IIC component
I6G98_03140	COG1397	ADP-ribosylglycohydrolase
I6G98_03145	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6G98_03150	COG2188	Transcriptional regulator
I6G98_03155	COG3757	hydrolase, family 25
I6G98_03160	COG0351	phosphomethylpyrimidine kinase
I6G98_03180	COG5455	response to cobalt ion
I6G98_03185	COG3539	Fimbrial protein
I6G98_03205	COG3121	Chaperone
I6G98_03210	COG3539	Fimbrial protein
I6G98_03230	COG0489	protein tyrosine kinase activity
I6G98_03245	COG3831	ATPase activity
I6G98_03275	COG3552	Protein containing von Willebrand factor type A (VWA) domain
I6G98_03280	COG4715	Zinc finger, swim domain protein
I6G98_03285	COG4808	Protein conserved in bacteria
I6G98_03290	COG4807	Protein conserved in bacteria
I6G98_03295	COG3279	Response regulator of the LytR AlgR family
I6G98_03300	COG3275	phosphorelay sensor kinase activity
I6G98_03315	COG0500	methyltransferase
I6G98_03330	COG5301	cellulose 1,4-beta-cellobiosidase activity
I6G98_03405	COG0740	serine-type endopeptidase activity
I6G98_03455	COG3772	lysozyme
I6G98_03505	COG0305	Participates in initiation and elongation during chromosome replication
I6G98_03510	COG1484	DNA-dependent DNA replication
I6G98_03530	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
I6G98_03595	COG0582	viral genome integration into host DNA
I6G98_03600	COG0789	Transcriptional regulator
I6G98_03610	COG1174	glycine betaine transport
I6G98_03615	COG1125	glycine betaine transport
I6G98_03620	COG1174	glycine betaine transport
I6G98_03625	COG1732	Glycine betaine
I6G98_03630	COG1472	Belongs to the glycosyl hydrolase 3 family
I6G98_03635	COG0277	FAD linked oxidase domain protein
I6G98_03640	COG1686	Belongs to the peptidase S11 family
I6G98_03650	COG0586	Pfam SNARE associated Golgi protein
I6G98_03655	COG1028	Short-chain dehydrogenase reductase Sdr
I6G98_03660	COG1538	Outer membrane efflux protein
I6G98_03670	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I6G98_03680	COG1346	cytolysis
I6G98_03690	COG2949	membrane
I6G98_03700	COG0493	'glutamate synthase
I6G98_03705	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
I6G98_03705	COG0167	dihydroorotate dehydrogenase activity
I6G98_03710	COG4211	Belongs to the binding-protein-dependent transport system permease family
I6G98_03715	COG1129	ABC transporter
I6G98_03720	COG1879	ABC-type sugar transport system periplasmic component
I6G98_03725	COG1609	Transcriptional regulator
I6G98_03730	COG2311	Membrane
I6G98_03740	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
I6G98_03745	COG4771	TonB-dependent receptor
I6G98_03750	COG0833	amino acid
I6G98_03755	COG0583	DNA-binding transcription factor activity
I6G98_03760	COG2855	membrane
I6G98_03770	COG1522	sequence-specific DNA binding
I6G98_03770	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6G98_03775	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I6G98_03785	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I6G98_03790	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I6G98_03795	COG2313	pseudouridylate synthase activity
I6G98_03800	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6G98_03805	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
I6G98_03805	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6G98_03805	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6G98_03810	COG1105	Belongs to the carbohydrate kinase PfkB family
I6G98_03815	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6G98_03815	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6G98_03820	COG2814	Major facilitator Superfamily
I6G98_03835	COG0246	Mannitol dehydrogenase
I6G98_03840	COG0523	cobalamin synthesis protein
I6G98_03845	COG0671	phosphoesterase, PA-phosphatase related
I6G98_03850	COG0791	NLP P60 protein
I6G98_03855	COG2200	EAL domain
I6G98_03860	COG4166	transmembrane transport
I6G98_03865	COG4174	ABC transporter (Permease)
I6G98_03870	COG4239	(ABC) transporter, permease
I6G98_03875	COG4172	Belongs to the ABC transporter superfamily
I6G98_03885	COG2814	Major facilitator Superfamily
I6G98_03890	COG1187	pseudouridine synthase activity
I6G98_03895	COG1061	Type III restriction enzyme res subunit
I6G98_03915	COG3083	sulfuric ester hydrolase activity
I6G98_03930	COG2197	response regulator
I6G98_03935	COG4235	cytochrome complex assembly
I6G98_03935	COG3088	subunit of a heme lyase
I6G98_03940	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
I6G98_03945	COG1138	Cytochrome C-type biogenesis protein
I6G98_03955	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I6G98_03960	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I6G98_03965	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
I6G98_03970	COG4133	protoheme IX ABC transporter activity
I6G98_03975	COG3005	denitrification pathway
I6G98_03980	COG3043	anaerobic respiration
I6G98_03985	COG0348	domain, Protein
I6G98_03990	COG0437	4 iron, 4 sulfur cluster binding
I6G98_04000	COG3062	negative regulation of establishment of protein localization
I6G98_04005	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6G98_04005	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6G98_04020	COG4615	Cyclic peptide transporter
I6G98_04040	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I6G98_04040	COG2169	Transcriptional regulator
I6G98_04045	COG1477	protein flavinylation
I6G98_04050	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
I6G98_04055	COG0642	Histidine kinase
I6G98_04055	COG2198	Histidine kinase
I6G98_04060	COG2197	response regulator
I6G98_04065	COG0784	Response regulator, receiver
I6G98_04065	COG2205	protein histidine kinase activity
I6G98_04070	COG3852	Histidine kinase
I6G98_04075	COG2204	response regulator
I6G98_04080	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
I6G98_04085	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
I6G98_04090	COG2031	fatty acid transporter
I6G98_04095	COG0183	Belongs to the thiolase family
I6G98_04100	COG4676	Protein conserved in bacteria
I6G98_04105	COG5445	Predicted secreted protein (DUF2300)
I6G98_04110	COG2373	Large extracellular alpha-helical protein
I6G98_04115	COG3234	Protein of unknown function (DUF1175)
I6G98_04120	COG4685	Uncharacterized protein conserved in bacteria (DUF2138)
I6G98_04125	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
I6G98_04140	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6G98_04145	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6G98_04150	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6G98_04155	COG3642	lipopolysaccharide core region biosynthetic process
I6G98_04165	COG0584	glycerophosphoryl diester phosphodiesterase
I6G98_04170	COG2271	Major facilitator Superfamily
I6G98_04175	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
I6G98_04185	COG0247	lactate metabolic process
I6G98_04190	COG5464	transposase or invertase
I6G98_04200	COG2271	Major facilitator Superfamily
I6G98_04210	COG1414	Transcriptional regulator
I6G98_04280	COG0318	PFAM AMP-dependent synthetase and ligase
I6G98_04290	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
I6G98_04305	COG1169	isochorismate synthase
I6G98_04310	COG4575	ribosome binding
I6G98_04315	COG2153	protein acetylation
I6G98_04345	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6G98_04350	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I6G98_04360	COG0839	Belongs to the complex I subunit 6 family
I6G98_04375	COG1034	ATP synthesis coupled electron transport
I6G98_04380	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
I6G98_04385	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
I6G98_04405	COG0583	DNA-binding transcription factor activity
I6G98_04410	COG0436	Aminotransferase
I6G98_04420	COG0471	metal ion transport
I6G98_04420	COG0490	domain, Protein
I6G98_04425	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6G98_04440	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
I6G98_04445	COG0280	phosphate acetyltransferase
I6G98_04445	COG0857	belongs to the CobB CobQ family
I6G98_04455	COG1288	antiporter activity
I6G98_04460	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
I6G98_04465	COG0622	Phosphoesterase
I6G98_04470	COG0625	glutathione transferase activity
I6G98_04475	COG0625	glutathione transferase activity
I6G98_04480	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
I6G98_04485	COG1090	epimerase
I6G98_04490	COG5464	transposase or invertase
I6G98_04495	COG4598	ABC transporter
I6G98_04500	COG4160	amino acid transport
I6G98_04505	COG4215	(ABC) transporter
I6G98_04510	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6G98_04515	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6G98_04520	COG0163	prenyltransferase activity
I6G98_04525	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
I6G98_04530	COG1286	toxin biosynthetic process
I6G98_04535	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
I6G98_04540	COG0285	dihydrofolate synthase activity
I6G98_04550	COG0586	Pfam SNARE associated Golgi protein
I6G98_04560	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
I6G98_04575	COG2814	Major facilitator Superfamily
I6G98_04580	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I6G98_04595	COG3101	peptidyl-lysine hydroxylation
I6G98_04600	COG0730	response to heat
I6G98_04630	COG3539	Fimbrial protein
I6G98_04635	COG3539	Fimbrial protein
I6G98_04640	COG3539	Fimbrial protein
I6G98_04645	COG3121	Chaperone
I6G98_04650	COG3188	usher protein
I6G98_04655	COG3539	Fimbrial protein
I6G98_04660	COG2062	phosphohistidine phosphatase, SixA
I6G98_04675	COG3691	Protein conserved in bacteria
I6G98_04680	COG2067	long-chain fatty acid transport protein
I6G98_04700	COG2853	Lipoprotein
I6G98_04705	COG2116	formate transmembrane transporter activity
I6G98_04715	COG0582	viral genome integration into host DNA
I6G98_04780	COG0653	protein targeting
I6G98_04805	COG0583	DNA-binding transcription factor activity
I6G98_04810	COG2610	gluconate transmembrane transporter activity
I6G98_04820	COG0477	Major facilitator Superfamily
I6G98_04825	COG1566	PFAM secretion protein HlyD family protein
I6G98_04830	COG2197	response regulator
I6G98_04835	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6G98_04835	COG0784	Response regulator, receiver
I6G98_04835	COG2198	Histidine kinase
I6G98_04835	COG2205	protein histidine kinase activity
I6G98_04840	COG1804	L-carnitine dehydratase bile acid-inducible protein F
I6G98_04845	COG0679	Auxin Efflux Carrier
I6G98_04850	COG0028	Belongs to the TPP enzyme family
I6G98_04875	COG1560	Kdo2-lipid A biosynthetic process
I6G98_04885	COG0436	Aminotransferase
I6G98_04890	COG3275	phosphorelay sensor kinase activity
I6G98_04895	COG3279	Response regulator of the LytR AlgR family
I6G98_04900	COG2207	Transcriptional regulator
I6G98_04910	COG1363	Peptidase, m42
I6G98_04915	COG0006	proline dipeptidase activity
I6G98_04920	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6G98_04935	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6G98_04960	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
I6G98_04975	COG2190	(PTS) system
I6G98_04980	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I6G98_04985	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6G98_04990	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I6G98_05010	COG3530	Putative quorum-sensing-regulated virulence factor
I6G98_05015	COG0385	Bile acid
I6G98_05020	COG0583	DNA-binding transcription factor activity
I6G98_05060	COG3415	Transposase
I6G98_05065	COG3415	Transposase
I6G98_05080	COG2200	EAL domain
I6G98_05080	COG2199	diguanylate cyclase activity
I6G98_05100	COG4884	unkown
I6G98_05100	COG3831	ATPase activity
I6G98_05105	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
I6G98_05110	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
I6G98_05115	COG4208	sulfate ABC transporter
I6G98_05120	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
I6G98_05125	COG4150	thiosulfate binding
I6G98_05130	COG1028	Short-chain dehydrogenase reductase Sdr
I6G98_05145	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6G98_05145	COG1263	PTS System
I6G98_05150	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I6G98_05155	COG2837	iron assimilation
I6G98_05175	COG0860	N-Acetylmuramoyl-L-alanine amidase
I6G98_05185	COG2207	Transcriptional regulator
I6G98_05190	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
I6G98_05195	COG4816	utilization protein
I6G98_05205	COG3385	transposase activity
I6G98_05215	COG4303	Ethanolamine ammonia lyase large subunit
I6G98_05220	COG4819	ethanolamine utilization protein
I6G98_05225	COG3192	ethanolamine utilization protein
I6G98_05230	COG1454	alcohol dehydrogenase
I6G98_05235	COG4820	ethanolamine utilization protein (EutJ)
I6G98_05240	COG1012	belongs to the aldehyde dehydrogenase family
I6G98_05245	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
I6G98_05250	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
I6G98_05255	COG0280	phosphate acetyltransferase
I6G98_05260	COG4812	Cobalamin adenosyltransferase
I6G98_05265	COG4766	ethanolamine catabolic process
I6G98_05270	COG4917	ethanolamine utilization protein
I6G98_05275	COG4810	utilization protein
I6G98_05280	COG0280	phosphate acetyltransferase
I6G98_05280	COG0281	malic enzyme
I6G98_05285	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
I6G98_05290	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
I6G98_05295	COG5342	invasion associated locus B
I6G98_05305	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6G98_05305	COG0493	'glutamate synthase
I6G98_05310	COG3850	Histidine kinase
I6G98_05315	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6G98_05325	COG1393	Belongs to the ArsC family
I6G98_05340	COG0400	carboxylic ester hydrolase activity
I6G98_05350	COG2321	neutral zinc metallopeptidase
I6G98_05370	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
I6G98_05380	COG2716	regulation of RNA biosynthetic process
I6G98_05385	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
I6G98_05390	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6G98_05400	COG0650	Formate hydrogenlyase subunit 4
I6G98_05405	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
I6G98_05410	COG4237	Hydrogenase 4 membrane
I6G98_05415	COG0651	ATP synthesis coupled electron transport
I6G98_05420	COG3261	NADH dehydrogenase
I6G98_05420	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
I6G98_05425	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6G98_05430	COG3260	NADH ubiquinone oxidoreductase 20
I6G98_05440	COG3604	Transcriptional regulator
I6G98_05445	COG3604	Transcriptional regulator
I6G98_05450	COG2116	formate transmembrane transporter activity
I6G98_05455	COG3547	Transposase (IS116 IS110 IS902 family)
I6G98_05465	COG0628	permease
I6G98_05470	COG4783	chaperone-mediated protein folding
I6G98_05475	COG1393	Belongs to the ArsC family
I6G98_05485	COG2233	PERMEase
I6G98_05500	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
I6G98_05505	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
I6G98_05510	COG0248	Ppx GppA phosphatase
I6G98_05540	COG3133	Outer membrane lipoprotein
I6G98_05555	COG0517	IMP dehydrogenase activity
I6G98_05555	COG0516	GMP reductase activity
I6G98_05565	COG1645	bacterial-type flagellum-dependent swarming motility
I6G98_05580	COG2976	Protein conserved in bacteria
I6G98_05610	COG4953	penicillin-binding protein 1C
I6G98_05615	COG2373	Large extracellular alpha-helical protein
I6G98_05620	COG2897	thiosulfate sulfurtransferase activity
I6G98_05635	COG2975	iron-sulfur cluster assembly
I6G98_05640	COG0633	Ferredoxin
I6G98_05660	COG0822	iron-sulfur transferase activity
I6G98_05680	COG0483	inositol monophosphate 1-phosphatase activity
I6G98_05685	COG1073	alpha beta
I6G98_05690	COG3711	transcriptional antiterminator
I6G98_05695	COG2814	Major facilitator Superfamily
I6G98_05700	COG0583	DNA-binding transcription factor activity
I6G98_05705	COG4638	Rieske (2fe-2S)
I6G98_05730	COG2259	Doxx family
I6G98_05735	COG2017	converts alpha-aldose to the beta-anomer
I6G98_05755	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6G98_05760	COG1129	ABC transporter
I6G98_05765	COG1879	ABC-type sugar transport system periplasmic component
I6G98_05770	COG0457	Tetratricopeptide repeat
I6G98_05775	COG1940	carbohydrate kinase activity
I6G98_05785	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6G98_05785	COG1017	nitric oxide dioxygenase activity
I6G98_05790	COG0347	Belongs to the P(II) protein family
I6G98_05795	COG2204	response regulator
I6G98_05800	COG3170	Tfp pilus assembly protein FimV
I6G98_05805	COG2205	protein histidine kinase activity
I6G98_05810	COG0047	phosphoribosylformylglycinamidine synthase activity
I6G98_05810	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
I6G98_05825	COG0560	Phosphoserine phosphatase
I6G98_05830	COG1737	Transcriptional regulator
I6G98_05835	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6G98_05850	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
I6G98_05870	COG0681	Belongs to the peptidase S26 family
I6G98_05880	COG3086	response to oxidative stress
I6G98_05885	COG3026	antisigma factor binding
I6G98_05890	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
I6G98_05895	COG1595	DNA-templated transcription, initiation
I6G98_05925	COG0513	Belongs to the DEAD box helicase family
I6G98_05930	COG0583	DNA-binding transcription factor activity
I6G98_05950	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6G98_05955	COG3118	belongs to the thioredoxin family
I6G98_05960	COG3148	PFAM DTW domain containing protein
I6G98_05965	COG0045	succinate-CoA ligase (ADP-forming) activity
I6G98_05965	COG1042	CoA-binding domain protein
I6G98_05965	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6G98_05970	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6G98_05975	COG5544	Lipoprotein
I6G98_05980	COG0477	Major facilitator Superfamily
I6G98_06005	COG0542	response to heat
I6G98_06015	COG0564	pseudouridine synthase activity
I6G98_06020	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6G98_06025	COG3385	transposase activity
I6G98_06030	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
I6G98_06040	COG1605	Chorismate mutase
I6G98_06040	COG0077	Prephenate dehydratase
I6G98_06045	COG0287	Prephenate dehydrogenase
I6G98_06045	COG1605	Chorismate mutase
I6G98_06050	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I6G98_06070	COG2885	chlorophyll binding
I6G98_06095	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
I6G98_06100	COG4137	Cytochrome C assembly protein
I6G98_06105	COG4536	flavin adenine dinucleotide binding
I6G98_06120	COG0497	DNA recombination
I6G98_06125	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6G98_06135	COG2867	negative regulation of translational initiation
I6G98_06155	COG3547	Transposase (IS116 IS110 IS902 family)
I6G98_06175	COG1012	belongs to the aldehyde dehydrogenase family
I6G98_06180	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
I6G98_06185	COG1113	amino acid transport
I6G98_06190	COG1802	Transcriptional regulator
I6G98_06195	COG1652	LysM domain
I6G98_06200	COG0401	homolog of Blt101
I6G98_06205	COG0640	Transcriptional regulator
I6G98_06210	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I6G98_06215	COG2916	Histone family protein nucleoid-structuring protein H-NS
I6G98_06235	COG4575	ribosome binding
I6G98_06240	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
I6G98_06250	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6G98_06255	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
I6G98_06260	COG4175	Glycine betaine
I6G98_06265	COG4176	ABC-type proline glycine betaine transport system permease component
I6G98_06270	COG2113	Glycine betaine
I6G98_06275	COG2814	Major facilitator Superfamily
I6G98_06280	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
I6G98_06290	COG1846	Transcriptional regulator
I6G98_06295	COG1566	PFAM secretion protein HlyD family protein
I6G98_06315	COG1238	metal cluster binding
I6G98_06320	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6G98_06350	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
I6G98_06370	COG1546	Belongs to the CinA family
I6G98_06375	COG2951	lytic endotransglycosylase activity
I6G98_06380	COG3730	PTS system glucitol sorbitol-specific
I6G98_06385	COG3732	PTS system glucitol sorbitol-specific
I6G98_06395	COG1028	Short-chain dehydrogenase reductase Sdr
I6G98_06400	COG4578	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6G98_06405	COG1349	DNA-binding transcription factor activity
I6G98_06430	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
I6G98_06435	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6G98_06440	COG1609	Transcriptional regulator
I6G98_06455	COG5499	transcription regulator containing HTH domain
I6G98_06460	COG4680	protein conserved in bacteria
I6G98_06470	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
I6G98_06480	COG3260	NADH ubiquinone oxidoreductase 20
I6G98_06485	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6G98_06490	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
I6G98_06490	COG3261	NADH dehydrogenase
I6G98_06495	COG0650	Formate hydrogenlyase subunit 4
I6G98_06500	COG0651	ATP synthesis coupled electron transport
I6G98_06505	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6G98_06515	COG0375	protein maturation
I6G98_06520	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
I6G98_06525	COG0298	carbon dioxide binding
I6G98_06530	COG0409	Hydrogenase expression formation protein
I6G98_06535	COG0309	Hydrogenase expression formation protein (HypE)
I6G98_06550	COG3423	Transcriptional regulator
I6G98_06565	COG2842	Transposition protein
I6G98_06590	COG4396	Host-nuclease inhibitor protein Gam
I6G98_06640	COG5566	PFAM Mor transcription activator
I6G98_06665	COG0640	Transcriptional regulator
I6G98_06675	COG4373	Mu-like prophage FluMu protein gp28
I6G98_06680	COG4383	Mu-like prophage protein gp29
I6G98_06685	COG2369	cell adhesion
I6G98_06695	COG5005	Phage virion morphogenesis
I6G98_06700	COG4388	Caudovirus prohead serine protease
I6G98_06705	COG4397	Mu-like prophage major head subunit gpT
I6G98_06730	COG4386	tail sheath protein
I6G98_06740	COG4518	Phage tail assembly chaperone proteins, E, or 41 or 14
I6G98_06750	COG4228	DNA circulation
I6G98_06760	COG4384	Bacteriophage Mu Gp45 protein
I6G98_06765	COG4381	Mu-like prophage protein gp46
I6G98_06770	COG3299	homolog of phage Mu protein gp47
I6G98_06800	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
I6G98_06835	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
I6G98_06845	COG2084	Dehydrogenase
I6G98_06850	COG3395	kinase activity
I6G98_06855	COG0235	Class ii aldolase
I6G98_06860	COG3622	Belongs to the hyi family
I6G98_06865	COG2610	gluconate transmembrane transporter activity
I6G98_06875	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
I6G98_06890	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I6G98_06895	COG4942	peptidase
I6G98_06895	COG1388	LysM domain
I6G98_06950	COG2234	aminopeptidase activity
I6G98_06955	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I6G98_06960	COG1518	maintenance of DNA repeat elements
I6G98_06975	COG1857	crispr-associated protein
I6G98_07025	COG0720	synthase
I6G98_07030	COG0644	oxidoreductase
I6G98_07035	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
I6G98_07040	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
I6G98_07045	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
I6G98_07050	COG2086	electron transfer activity
I6G98_07055	COG0477	Major facilitator Superfamily
I6G98_07075	COG1028	Short-chain dehydrogenase reductase Sdr
I6G98_07085	COG1070	Carbohydrate kinase
I6G98_07100	COG1529	Aldehyde oxidase and xanthine dehydrogenase
I6G98_07100	COG2080	2 iron, 2 sulfur cluster binding
I6G98_07105	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
I6G98_07110	COG0402	S-adenosylhomocysteine deaminase activity
I6G98_07115	COG0493	'glutamate synthase
I6G98_07115	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6G98_07125	COG4942	peptidase
I6G98_07180	COG0814	amino acid
I6G98_07185	COG0183	Belongs to the thiolase family
I6G98_07195	COG1028	Short-chain dehydrogenase reductase Sdr
I6G98_07200	COG2814	Major facilitator Superfamily
I6G98_07205	COG1794	racemase activity, acting on amino acids and derivatives
I6G98_07210	COG0583	DNA-binding transcription factor activity
I6G98_07220	COG1609	Transcriptional regulator
I6G98_07235	COG0667	Aldo Keto reductase
I6G98_07245	COG0861	Integral membrane protein TerC family
I6G98_07265	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
I6G98_07280	COG2165	general secretion pathway protein
I6G98_07285	COG4795	General secretion pathway protein
I6G98_07295	COG4967	type IV pilus modification protein PilV
I6G98_07300	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
I6G98_07310	COG1074	ATP-dependent DNA helicase activity
I6G98_07315	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
I6G98_07320	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
I6G98_07320	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
I6G98_07325	COG0860	N-Acetylmuramoyl-L-alanine amidase
I6G98_07345	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
I6G98_07350	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
I6G98_07355	COG2166	iron-sulfur cluster assembly
I6G98_07360	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
I6G98_07370	COG0583	DNA-binding transcription factor activity
I6G98_07375	COG2363	Small membrane protein
I6G98_07385	COG1349	DNA-binding transcription factor activity
I6G98_07395	COG1070	Carbohydrate kinase
I6G98_07405	COG1129	ABC transporter
I6G98_07410	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6G98_07415	COG1609	Transcriptional regulator
I6G98_07420	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
I6G98_07430	COG0235	Class ii aldolase
I6G98_07435	COG1454	alcohol dehydrogenase
I6G98_07445	COG1760	l-serine dehydratase
I6G98_07450	COG0814	amino acid
I6G98_07455	COG1611	Belongs to the LOG family
I6G98_07470	COG3098	single-species biofilm formation
I6G98_07475	COG0564	pseudouridine synthase activity
I6G98_07480	COG0716	FMN binding
I6G98_07485	COG2271	Major facilitator Superfamily
I6G98_07495	COG4948	Mandelate Racemase Muconate Lactonizing
I6G98_07500	COG4999	Histidine kinase
I6G98_07500	COG3850	Histidine kinase
I6G98_07500	COG3437	response regulator, receiver
I6G98_07500	COG2205	protein histidine kinase activity
I6G98_07510	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I6G98_07515	COG2336	PFAM SpoVT AbrB
I6G98_07520	COG2337	Toxic component of a toxin-antitoxin (TA) module
I6G98_07525	COG3956	TIGRFAM MazG family protein
I6G98_07560	COG0602	queuosine metabolic process
I6G98_07575	COG0402	S-adenosylhomocysteine deaminase activity
I6G98_07580	COG2252	PERMEase
I6G98_07585	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6G98_07590	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6G98_07590	COG0493	'glutamate synthase
I6G98_07595	COG2233	PERMEase
I6G98_07630	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
I6G98_07635	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I6G98_07640	COG4974	Belongs to the 'phage' integrase family
I6G98_07645	COG0716	FMN binding
I6G98_07655	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
I6G98_07665	COG1272	protein, Hemolysin III
I6G98_07675	COG2723	6-phospho-beta-galactosidase activity
I6G98_07680	COG1028	Short-chain dehydrogenase reductase Sdr
I6G98_07705	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6G98_07710	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6G98_07715	COG0006	proline dipeptidase activity
I6G98_07735	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
I6G98_07750	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
I6G98_07765	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
I6G98_07765	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
I6G98_07770	COG1703	isobutyryl-CoA mutase activity
I6G98_07775	COG1024	Enoyl-CoA hydratase
I6G98_07780	COG0427	acetyl-CoA hydrolase
I6G98_07785	COG0583	DNA-binding transcription factor activity
I6G98_07790	COG2968	Membrane
I6G98_07800	COG0668	transmembrane transport
I6G98_07805	COG0191	fructose-bisphosphate aldolase activity
I6G98_07835	COG1122	ATPase activity
I6G98_07840	COG1122	ATPase activity
I6G98_07845	COG1072	(Pantothenic acid kinase))
I6G98_07855	COG1494	fructose-1,6-bisphosphatase
I6G98_07860	COG1063	alcohol dehydrogenase
I6G98_07865	COG2213	PTS system mannitol-specific
I6G98_07880	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
I6G98_07885	COG0501	Belongs to the peptidase M48B family
I6G98_07900	COG1166	arginine decarboxylase activity
I6G98_07920	COG2814	Major facilitator Superfamily
I6G98_07930	COG2356	endonuclease I
I6G98_07935	COG1385	rRNA (uridine-N3-)-methyltransferase activity
I6G98_07940	COG0189	ligase activity
I6G98_07955	COG2805	Type II/IV secretion system protein
I6G98_07960	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
I6G98_07965	COG0762	integral membrane protein
I6G98_07980	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I6G98_07985	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
I6G98_07990	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
I6G98_08005	COG0252	asparaginase activity
I6G98_08015	COG3171	Protein conserved in bacteria
I6G98_08025	COG1194	a g-specific adenine glycosylase
I6G98_08040	COG2211	Major facilitator Superfamily
I6G98_08050	COG3547	Transposase (IS116 IS110 IS902 family)
I6G98_08055	COG1982	Orn Lys Arg decarboxylase major
I6G98_08060	COG1811	Na channel or pump
I6G98_08100	COG2165	general secretion pathway protein
I6G98_08105	COG1459	type II secretion system
I6G98_08110	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I6G98_08130	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
I6G98_08140	COG1620	l-lactate permease
I6G98_08145	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
I6G98_08150	COG3193	protein, possibly involved in utilization of glycolate and propanediol
I6G98_08155	COG0247	lactate metabolic process
I6G98_08160	COG0277	FAD linked oxidase domain protein
I6G98_08165	COG0277	FAD linked oxidase domain protein
I6G98_08170	COG2186	Transcriptional regulator
I6G98_08175	COG0456	acetyltransferase
I6G98_08185	COG0318	PFAM AMP-dependent synthetase and ligase
I6G98_08195	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
I6G98_08200	COG0156	8-amino-7-oxononanoate synthase activity
I6G98_08210	COG0795	lipopolysaccharide-transporting ATPase activity
I6G98_08215	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
I6G98_08225	COG2244	polysaccharide biosynthetic process
I6G98_08230	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
I6G98_08235	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
I6G98_08240	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
I6G98_08245	COG0306	phosphate transporter
I6G98_08260	COG0754	glutathionylspermidine amidase activity
I6G98_08265	COG0625	glutathione transferase activity
I6G98_08270	COG0298	carbon dioxide binding
I6G98_08280	COG1773	rubredoxin
I6G98_08285	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
I6G98_08290	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
I6G98_08295	COG5557	Pfam Polysulphide reductase, NrfD
I6G98_08300	COG0437	4 iron, 4 sulfur cluster binding
I6G98_08305	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
I6G98_08320	COG0667	Aldo Keto reductase
I6G98_08330	COG1028	Short-chain dehydrogenase reductase Sdr
I6G98_08335	COG0848	biopolymer transport protein
I6G98_08340	COG0811	peptide transport
I6G98_08345	COG0626	cystathionine gamma-synthase activity
I6G98_08350	COG0586	Pfam SNARE associated Golgi protein
I6G98_08355	COG2207	Transcriptional regulator
I6G98_08360	COG1979	alcohol dehydrogenase
I6G98_08365	COG0656	L-ascorbic acid biosynthetic process
I6G98_08375	COG4238	major outer membrane lipoprotein
I6G98_08390	COG1032	radical SAM domain protein
I6G98_08395	COG2132	Multicopper oxidase
I6G98_08400	COG0204	Acyl-transferase
I6G98_08405	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
I6G98_08425	COG3111	PFAM Bacterial OB fold (BOF) protein
I6G98_08430	COG0745	RESPONSE REGULATOR receiver
I6G98_08435	COG0642	Histidine kinase
I6G98_08450	COG2249	NAD(P)H dehydrogenase (quinone) activity
I6G98_08455	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
I6G98_08460	COG0187	DNA topoisomerase II activity
I6G98_08465	COG3150	esterase
I6G98_08470	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
I6G98_08475	COG3151	Protein conserved in bacteria
I6G98_08480	COG0494	nUDIX hydrolase
I6G98_08485	COG1538	Outer membrane efflux protein
I6G98_08495	COG0754	glutathionylspermidine amidase activity
I6G98_08500	COG3384	dioxygenase
I6G98_08520	COG2960	long-chain fatty acid transporting porin activity
I6G98_08545	COG2268	Band 7 protein
I6G98_08570	COG3025	triphosphatase activity
I6G98_08575	COG4991	sh3 domain protein
I6G98_08590	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
I6G98_08615	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
I6G98_08620	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
I6G98_08625	COG0471	metal ion transport
I6G98_08635	COG0828	Belongs to the bacterial ribosomal protein bS21 family
I6G98_08640	COG0358	DNA primase activity
I6G98_08645	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I6G98_08650	COG3385	transposase activity
I6G98_08665	COG2375	cellular response to nickel ion
I6G98_08670	COG1695	Transcriptional regulator
I6G98_08675	COG0840	transmembrane signaling receptor activity
I6G98_08690	COG1609	Transcriptional regulator
I6G98_08695	COG3250	beta-galactosidase activity
I6G98_08700	COG2731	YhcH YjgK YiaL family protein
I6G98_08705	COG0531	amino acid
I6G98_08715	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
I6G98_08715	COG3408	Glycogen debranching enzyme
I6G98_08720	COG0446	pyridine nucleotide-disulphide oxidoreductase
I6G98_08720	COG1902	pentaerythritol trinitrate reductase activity
I6G98_08725	COG5499	transcription regulator containing HTH domain
I6G98_08730	COG4680	protein conserved in bacteria
I6G98_08740	COG1451	nucleotide metabolic process
I6G98_08745	COG2949	membrane
I6G98_08750	COG0673	inositol 2-dehydrogenase activity
I6G98_08755	COG0861	Integral membrane protein TerC family
I6G98_08760	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
I6G98_08770	COG2721	sulfolactate sulfo-lyase activity
I6G98_08780	COG2271	Major facilitator Superfamily
I6G98_08820	COG2186	Transcriptional regulator
I6G98_08825	COG0586	Pfam SNARE associated Golgi protein
I6G98_08835	COG1422	Protein of unknown function (DUF1090)
I6G98_08840	COG4575	ribosome binding
I6G98_08845	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
I6G98_08855	COG2259	Doxx family
I6G98_08860	COG0435	Glutathione S-transferase
I6G98_08865	COG3152	Membrane
I6G98_08870	COG3152	Membrane
I6G98_08880	COG0583	DNA-binding transcription factor activity
I6G98_08885	COG1741	Belongs to the pirin family
I6G98_08900	COG0814	amino acid
I6G98_08905	COG1760	l-serine dehydratase
I6G98_08910	COG0251	oxidation-reduction process
I6G98_08915	COG1882	Formate acetyltransferase
I6G98_08920	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
I6G98_08930	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I6G98_08935	COG0583	DNA-binding transcription factor activity
I6G98_08970	COG1929	Belongs to the glycerate kinase type-1 family
I6G98_08975	COG2084	Dehydrogenase
I6G98_08985	COG2271	Major facilitator Superfamily
I6G98_08990	COG2721	sulfolactate sulfo-lyase activity
I6G98_08995	COG2002	toxin-antitoxin pair type II binding
I6G98_09005	COG1349	DNA-binding transcription factor activity
I6G98_09015	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6G98_09025	COG3716	PTS system mannose fructose sorbose family IID component
I6G98_09030	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6G98_09035	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
I6G98_09040	COG2222	sugar isomerase
I6G98_09055	COG0493	'glutamate synthase
I6G98_09060	COG0067	glutamate synthase
I6G98_09060	COG0069	glutamate synthase activity
I6G98_09060	COG0070	glutamate synthase
I6G98_09065	COG1242	4 iron, 4 sulfur cluster binding
I6G98_09070	COG5002	protein histidine kinase activity
I6G98_09070	COG2198	Histidine kinase
I6G98_09070	COG0784	Response regulator, receiver
I6G98_09075	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
I6G98_09085	COG0515	serine threonine protein kinase
I6G98_09090	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6G98_09105	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
I6G98_09110	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
I6G98_09115	COG1137	ATPase activity
I6G98_09120	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
I6G98_09125	COG3117	lipopolysaccharide transmembrane transporter activity
I6G98_09130	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
I6G98_09135	COG0517	IMP dehydrogenase activity
I6G98_09135	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
I6G98_09140	COG0530	calcium, potassium:sodium antiporter activity
I6G98_09145	COG1127	ABC transporter
I6G98_09150	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
I6G98_09155	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
I6G98_09160	COG2854	intermembrane phospholipid transfer
I6G98_09165	COG3113	response to antibiotic
I6G98_09170	COG5007	Belongs to the BolA IbaG family
I6G98_09180	COG3423	Transcriptional regulator
I6G98_09185	COG0142	geranyltranstransferase activity
I6G98_09200	COG0697	spore germination
I6G98_09210	COG2027	D-alanyl-D-alanine carboxypeptidase
I6G98_09215	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I6G98_09220	COG1534	Rna-binding protein
I6G98_09230	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
I6G98_09235	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
I6G98_09245	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
I6G98_09255	COG2194	sulfuric ester hydrolase activity
I6G98_09275	COG0195	Participates in both transcription termination and antitermination
I6G98_09315	COG0513	Belongs to the DEAD box helicase family
I6G98_09320	COG0814	amino acid
I6G98_09325	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
I6G98_09330	COG0826	peptidase U32
I6G98_09335	COG0826	peptidase U32
I6G98_09340	COG3154	lipid carrier protein
I6G98_09345	COG3153	acetyltransferase
I6G98_09360	COG0693	protein deglycase activity
I6G98_09365	COG0702	epimerase
I6G98_09370	COG0701	Predicted permease
I6G98_09375	COG2823	Periplasmic or secreted lipoprotein
I6G98_09395	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
I6G98_09415	COG3188	usher protein
I6G98_09430	COG4804	nuclease activity
I6G98_09435	COG2731	YhcH YjgK YiaL family protein
I6G98_09465	COG3069	C4-dicarboxylate transmembrane transporter activity
I6G98_09470	COG2969	positive regulation of protein catabolic process
I6G98_09475	COG0625	glutathione transferase activity
I6G98_09490	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
I6G98_09495	COG3105	Protein conserved in bacteria
I6G98_09500	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6G98_09505	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6G98_09525	COG2732	(Barnase) inhibitor
I6G98_09550	COG0583	DNA-binding transcription factor activity
I6G98_09555	COG0312	modulator of DNA gyrase
I6G98_09560	COG3164	Protein of unknown function
I6G98_09565	COG1530	ribonuclease E activity
I6G98_09575	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
I6G98_09580	COG1792	Involved in formation and maintenance of cell shape
I6G98_09585	COG1077	Cell shape determining protein MreB Mrl
I6G98_09590	COG2199	diguanylate cyclase activity
I6G98_09590	COG2200	EAL domain
I6G98_09595	COG0604	alcohol dehydrogenase
I6G98_09605	COG0511	ligase activity, forming carbon-carbon bonds
I6G98_09610	COG0439	Biotin carboxylase
I6G98_09615	COG3924	membrane
I6G98_09620	COG4145	pantothenate transmembrane transporter activity
I6G98_09630	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I6G98_09640	COG2189	Belongs to the N(4) N(6)-methyltransferase family
I6G98_09650	COG1309	transcriptional regulator
I6G98_09655	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6G98_09670	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6G98_09675	COG4597	amino acid ABC transporter
I6G98_09680	COG0765	amino acid transport
I6G98_09725	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
I6G98_09745	COG0551	DNA topoisomerase type I activity
I6G98_09750	COG2922	Belongs to the Smg family
I6G98_09775	COG0569	domain protein
I6G98_09795	COG3036	rescue of stalled ribosome
I6G98_09800	COG0789	Transcriptional regulator
I6G98_09840	COG0201	protein transport
I6G98_09930	COG0089	rRNA binding
I6G98_10015	COG2964	Protein conserved in bacteria
I6G98_10020	COG0545	Peptidyl-prolyl cis-trans isomerase
I6G98_10030	COG1047	Peptidyl-prolyl cis-trans
I6G98_10035	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
I6G98_10050	COG0488	(ABC) transporter
I6G98_10055	COG0429	hydrolase of the alpha beta-hydrolase fold
I6G98_10065	COG3954	Phosphoribulokinase
I6G98_10070	COG1765	OsmC-like protein
I6G98_10075	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I6G98_10080	COG1289	transmembrane transporter activity
I6G98_10085	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
I6G98_10090	COG0512	Glutamine amidotransferase of anthranilate synthase
I6G98_10095	COG2184	nucleotidyltransferase activity
I6G98_10105	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
I6G98_10115	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
I6G98_10120	COG2146	nitrite reductase [NAD(P)H] activity
I6G98_10125	COG2116	formate transmembrane transporter activity
I6G98_10145	COG2222	sugar isomerase
I6G98_10150	COG1082	Xylose isomerase domain protein TIM barrel
I6G98_10160	COG2188	Transcriptional regulator
I6G98_10165	COG0626	cystathionine gamma-synthase activity
I6G98_10180	COG1735	metal-dependent hydrolase with the TIM-barrel fold
I6G98_10185	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
I6G98_10190	COG3457	Alanine racemase
I6G98_10200	COG2188	Transcriptional regulator
I6G98_10205	COG0180	Tryptophanyl-tRNA synthetase
I6G98_10215	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
I6G98_10220	COG0338	D12 class N6 adenine-specific DNA methyltransferase
I6G98_10225	COG3266	domain, Protein
I6G98_10240	COG4796	Type ii and iii secretion system protein
I6G98_10255	COG3166	PFAM Fimbrial assembly family protein
I6G98_10260	COG4972	Pilus assembly protein
I6G98_10265	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
I6G98_10270	COG0494	nUDIX hydrolase
I6G98_10280	COG1011	Hydrolase
I6G98_10285	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
I6G98_10300	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
I6G98_10320	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I6G98_10325	COG2183	response to ionizing radiation
I6G98_10330	COG1918	ferrous iron import across plasma membrane
I6G98_10335	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
I6G98_10345	COG5464	transposase or invertase
I6G98_10365	COG2610	gluconate transmembrane transporter activity
I6G98_10370	COG1640	4-alpha-glucanotransferase
I6G98_10375	COG0058	SHG alpha-glucan phosphorylase activity
I6G98_10405	COG0058	SHG alpha-glucan phosphorylase activity
I6G98_10430	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
I6G98_10435	COG2095	MarC family integral membrane protein
I6G98_10440	COG2610	gluconate transmembrane transporter activity
I6G98_10445	COG3265	gluconokinase activity
I6G98_10450	COG1609	Transcriptional regulator
I6G98_10455	COG1741	Belongs to the pirin family
I6G98_10460	COG0673	inositol 2-dehydrogenase activity
I6G98_10465	COG1247	-acetyltransferase
I6G98_10470	COG3157	Type VI secretion system effector, Hcp
I6G98_10490	COG0405	Gamma-glutamyltransferase
I6G98_10500	COG0584	glycerophosphoryl diester phosphodiesterase
I6G98_10510	COG0395	ABC-type sugar transport system, permease component
I6G98_10515	COG1175	transmembrane transport
I6G98_10535	COG0410	ABC transporter
I6G98_10540	COG0411	ABC transporter
I6G98_10545	COG4177	L-phenylalanine transmembrane transporter activity
I6G98_10550	COG0559	Belongs to the binding-protein-dependent transport system permease family
I6G98_10555	COG0683	leucine binding
I6G98_10560	COG0456	acetyltransferase
I6G98_10565	COG0683	leucine binding
I6G98_10570	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
I6G98_10575	COG2177	Part of the ABC transporter FtsEX involved in
I6G98_10580	COG2884	Cell division ATP-binding protein ftsE
I6G98_10585	COG0552	protein localization to endoplasmic reticulum
I6G98_10590	COG0742	ribosomal rna small subunit methyltransferase
I6G98_10595	COG3776	membrane
I6G98_10605	COG3714	YhhN family
I6G98_10620	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
I6G98_10635	COG0628	permease
I6G98_10640	COG2091	lysine biosynthetic process via aminoadipic acid
I6G98_10645	COG0747	negative chemotaxis
I6G98_10650	COG0601	transmembrane transport
I6G98_10655	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6G98_10685	COG0842	Transport permease protein
I6G98_10690	COG1129	ABC transporter
I6G98_10690	COG0842	Transport permease protein
I6G98_10695	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6G98_10715	COG2081	HI0933 family
I6G98_10720	COG0306	phosphate transporter
I6G98_10730	COG0589	response to stress
I6G98_10740	COG3104	oligopeptide transport
I6G98_10750	COG0339	signal peptide processing
I6G98_10755	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
I6G98_10760	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6G98_10770	COG0640	Transcriptional regulator
I6G98_10775	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
I6G98_10780	COG1393	Belongs to the ArsC family
I6G98_10800	COG3065	identical protein binding
I6G98_10805	COG2197	response regulator
I6G98_10810	COG1285	pathogenesis
I6G98_10825	COG3247	response to pH
I6G98_10830	COG2771	luxR family
I6G98_10845	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6G98_10850	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6G98_10855	COG2207	Transcriptional regulator
I6G98_10865	COG0076	glutamate decarboxylase activity
I6G98_10870	COG1858	cytochrome C peroxidase
I6G98_10885	COG3385	transposase activity
I6G98_10890	COG2197	response regulator
I6G98_10895	COG0583	DNA-binding transcription factor activity
I6G98_10900	COG1295	ribonuclease BN
I6G98_10905	COG0477	Major facilitator Superfamily
I6G98_10910	COG2982	Protein involved in outer membrane biogenesis
I6G98_10915	COG2200	EAL domain
I6G98_10925	COG0612	Peptidase, M16
I6G98_10935	COG2199	diguanylate cyclase activity
I6G98_10935	COG2200	EAL domain
I6G98_10940	COG3118	belongs to the thioredoxin family
I6G98_10940	COG0457	Tetratricopeptide repeat
I6G98_10945	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
I6G98_10950	COG1215	transferase activity, transferring glycosyl groups
I6G98_10955	COG1215	transferase activity, transferring glycosyl groups
I6G98_10980	COG2194	sulfuric ester hydrolase activity
I6G98_11010	COG0747	negative chemotaxis
I6G98_11025	COG2194	sulfuric ester hydrolase activity
I6G98_11030	COG2223	nitrite transmembrane transporter activity
I6G98_11035	COG5571	outer membrane autotransporter
I6G98_11040	COG2818	Glycosylase
I6G98_11045	COG0456	acetyltransferase
I6G98_11050	COG0243	molybdopterin cofactor binding
I6G98_11055	COG2885	chlorophyll binding
I6G98_11070	COG2944	sequence-specific DNA binding
I6G98_11075	COG1278	Cold shock
I6G98_11115	COG4682	membrane
I6G98_11120	COG4682	membrane
I6G98_11130	COG1070	Carbohydrate kinase
I6G98_11140	COG4213	ABC transporter substrate-binding protein
I6G98_11150	COG4214	carbohydrate transport
I6G98_11155	COG2207	Transcriptional regulator
I6G98_11155	COG1609	Transcriptional regulator
I6G98_11160	COG2992	FlgJ-related protein
I6G98_11165	COG0366	Alpha amylase catalytic
I6G98_11170	COG3977	Valine--pyruvate aminotransferase
I6G98_11175	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
I6G98_11180	COG1414	Transcriptional regulator
I6G98_11190	COG2731	YhcH YjgK YiaL family protein
I6G98_11195	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
I6G98_11210	COG0583	DNA-binding transcription factor activity
I6G98_11215	COG1566	PFAM secretion protein HlyD family protein
I6G98_11230	COG1012	belongs to the aldehyde dehydrogenase family
I6G98_11235	COG1454	alcohol dehydrogenase
I6G98_11240	COG3276	selenocysteine insertion sequence binding
I6G98_11250	COG0625	glutathione transferase activity
I6G98_11260	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
I6G98_11280	COG2213	PTS system mannitol-specific
I6G98_11280	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6G98_11290	COG3722	fumarate hydratase activity
I6G98_11310	COG5295	Hep Hag repeat protein
I6G98_11315	COG1620	l-lactate permease
I6G98_11320	COG2186	Transcriptional regulator
I6G98_11330	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
I6G98_11335	COG1045	serine acetyltransferase
I6G98_11350	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
I6G98_11355	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I6G98_11365	COG4942	peptidase
I6G98_11370	COG2861	carbohydrate metabolic process
I6G98_11375	COG1216	Glycosyl transferase, family 2
I6G98_11390	COG0156	8-amino-7-oxononanoate synthase activity
I6G98_11400	COG0859	PFAM glycosyl transferase family 9
I6G98_11405	COG0859	PFAM glycosyl transferase family 9
I6G98_11410	COG3307	-O-antigen
I6G98_11415	COG1216	Glycosyl transferase, family 2
I6G98_11420	COG1442	glycosyl transferase family 8
I6G98_11425	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
I6G98_11440	COG0515	serine threonine protein kinase
I6G98_11445	COG0438	transferase activity, transferring glycosyl groups
I6G98_11450	COG0859	PFAM glycosyl transferase family 9
I6G98_11455	COG1519	Transferase
I6G98_11485	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
I6G98_11510	COG1561	YicC-like family, N-terminal region
I6G98_11515	COG3645	SOS response
I6G98_11520	COG2860	membrane
I6G98_11530	COG0194	GDP metabolic process
I6G98_11540	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
I6G98_11545	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6G98_11550	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
I6G98_11560	COG0786	glutamate:sodium symporter activity
I6G98_11565	COG2233	PERMEase
I6G98_11570	COG2982	Protein involved in outer membrane biogenesis
I6G98_11575	COG1501	Belongs to the glycosyl hydrolase 31 family
I6G98_11580	COG2211	Major facilitator Superfamily
I6G98_11595	COG2814	Major facilitator Superfamily
I6G98_11600	COG0697	spore germination
I6G98_11605	COG1464	Belongs to the NlpA lipoprotein family
I6G98_11625	COG2252	PERMEase
I6G98_11635	COG2271	Major facilitator Superfamily
I6G98_11640	COG2271	Major facilitator Superfamily
I6G98_11645	COG3851	Histidine kinase
I6G98_11650	COG2197	response regulator
I6G98_11655	COG0440	acetolactate synthase activity
I6G98_11660	COG0028	Belongs to the TPP enzyme family
I6G98_11675	COG2814	Major facilitator Superfamily
I6G98_11680	COG0641	radical SAM
I6G98_11690	COG2149	membrane
I6G98_11700	COG3119	arylsulfatase activity
I6G98_11705	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
I6G98_11710	COG2207	Transcriptional regulator
I6G98_11725	COG2188	Transcriptional regulator
I6G98_11745	COG5645	(Lipo)protein
I6G98_11750	COG0823	Involved in the tonB-independent uptake of proteins
I6G98_11760	COG2271	Major facilitator Superfamily
I6G98_11770	COG0800	Aldolase
I6G98_11775	COG3734	2-keto-3-deoxy-galactonokinase
I6G98_11780	COG2186	Transcriptional regulator
I6G98_11790	COG0561	phosphatase activity
I6G98_11795	COG3753	Protein conserved in bacteria
I6G98_11800	COG0187	DNA topoisomerase II activity
I6G98_11810	COG0592	DNA-directed DNA polymerase activity
I6G98_11860	COG0814	amino acid
I6G98_11875	COG2091	lysine biosynthetic process via aminoadipic acid
I6G98_11880	COG0431	NADPH-dependent FMN reductase
I6G98_11885	COG2252	PERMEase
I6G98_11890	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6G98_11900	COG3196	Protein conserved in bacteria
I6G98_11905	COG0363	glucosamine-6-phosphate deaminase activity
I6G98_11930	COG0704	Plays a role in the regulation of phosphate uptake
I6G98_11935	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
I6G98_11940	COG0581	inorganic phosphate transmembrane transporter activity
I6G98_11945	COG0573	inorganic phosphate transmembrane transporter activity
I6G98_11950	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
I6G98_11965	COG3188	usher protein
I6G98_12040	COG3312	ion transport
I6G98_12055	COG0716	FMN binding
I6G98_12060	COG1522	sequence-specific DNA binding
I6G98_12080	COG3385	transposase activity
I6G98_12095	COG1129	ABC transporter
I6G98_12100	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6G98_12105	COG1879	ABC-type sugar transport system periplasmic component
I6G98_12110	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6G98_12115	COG1609	Transcriptional regulator
I6G98_12120	COG0477	Major facilitator Superfamily
I6G98_12125	COG2186	Transcriptional regulator
I6G98_12165	COG3085	chromosome segregation
I6G98_12170	COG0606	chelatase, subunit chli
I6G98_12190	COG3978	acetolactate synthase activity
I6G98_12195	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I6G98_12205	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
I6G98_12210	COG0583	DNA-binding transcription factor activity
I6G98_12220	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6G98_12225	COG3692	DNA binding
I6G98_12230	COG0210	DNA helicase
I6G98_12245	COG3118	belongs to the thioredoxin family
I6G98_12255	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
I6G98_12260	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
I6G98_12265	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
I6G98_12270	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
I6G98_12275	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
I6G98_12280	COG1088	dTDP-glucose 4,6-dehydratase activity
I6G98_12285	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
I6G98_12290	COG0456	acetyltransferase
I6G98_12295	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
I6G98_12300	COG2244	polysaccharide biosynthetic process
I6G98_12320	COG1113	amino acid transport
I6G98_12345	COG0641	radical SAM
I6G98_12350	COG3119	arylsulfatase activity
I6G98_12355	COG3071	HemY protein
I6G98_12360	COG2959	enzyme of heme biosynthesis
I6G98_12365	COG1587	Uroporphyrinogen-III synthase
I6G98_12375	COG3072	Adenylate cyclase
I6G98_12385	COG5567	small periplasmic lipoprotein
I6G98_12395	COG3159	Protein conserved in bacteria
I6G98_12405	COG1011	Hydrolase
I6G98_12410	COG0210	DNA helicase
I6G98_12415	COG3698	Phosphodiester glycosidase
I6G98_12420	COG3385	transposase activity
I6G98_12425	COG3698	Phosphodiester glycosidase
I6G98_12430	COG0598	Magnesium transport protein CorA
I6G98_12450	COG2962	Rard protein
I6G98_12455	COG2050	protein possibly involved in aromatic compounds catabolism
I6G98_12460	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
I6G98_12465	COG0514	ATP-dependent DNA helicase (RecQ)
I6G98_12470	COG1280	lysine exporter protein (LysE YggA)
I6G98_12475	COG1280	lysine exporter protein (LysE YggA)
I6G98_12480	COG2267	carboxylic ester hydrolase activity
I6G98_12485	COG0561	phosphatase activity
I6G98_12490	COG0697	spore germination
I6G98_12495	COG0583	DNA-binding transcription factor activity
I6G98_12520	COG0412	Dienelactone hydrolase
I6G98_12525	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
I6G98_12530	COG1322	Protein conserved in bacteria
I6G98_12540	COG3165	ubiquinone biosynthetic process from chorismate
I6G98_12550	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I6G98_12555	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I6G98_12560	COG0805	protein transport
I6G98_12570	COG0250	Participates in transcription elongation, termination and antitermination
I6G98_12575	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
I6G98_12580	COG0543	2 iron, 2 sulfur cluster binding
I6G98_12600	COG1739	Uncharacterized protein family UPF0029
I6G98_12605	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
I6G98_12610	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
I6G98_12640	COG1763	Mo-molybdopterin cofactor biosynthetic process
I6G98_12645	COG0746	molybdenum cofactor guanylyltransferase activity
I6G98_12650	COG3084	Protein conserved in bacteria
I6G98_12655	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
I6G98_12660	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I6G98_12665	COG5339	Protein conserved in bacteria
I6G98_12670	COG0204	Acyl-transferase
I6G98_12675	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I6G98_12675	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
I6G98_12690	COG0635	Involved in the biosynthesis of porphyrin-containing compound
I6G98_12700	COG2204	response regulator
I6G98_12705	COG3852	Histidine kinase
I6G98_12710	COG0174	glutamine synthetase
I6G98_12715	COG1217	gtp-binding protein TYPA
I6G98_12720	COG2188	Transcriptional regulator
I6G98_12725	COG1082	Xylose isomerase domain protein TIM barrel
I6G98_12730	COG2271	Major facilitator Superfamily
I6G98_12735	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
I6G98_12740	COG2211	Major facilitator Superfamily
I6G98_12745	COG2211	Major facilitator Superfamily
I6G98_12765	COG2017	converts alpha-aldose to the beta-anomer
I6G98_12770	COG2942	2-epimerase
I6G98_12775	COG3684	Belongs to the aldolase LacD family
I6G98_12780	COG2084	Dehydrogenase
I6G98_12785	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6G98_12790	COG1349	DNA-binding transcription factor activity
I6G98_12795	COG1011	Hydrolase
I6G98_12810	COG0456	acetyltransferase
I6G98_12825	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
I6G98_12835	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
I6G98_12840	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
I6G98_12850	COG2864	formate dehydrogenase
I6G98_12855	COG0437	4 iron, 4 sulfur cluster binding
I6G98_12910	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
I6G98_12920	COG2258	MOSC domain
I6G98_12925	COG2205	protein histidine kinase activity
I6G98_12930	COG0745	RESPONSE REGULATOR receiver
I6G98_12935	COG3678	ATP-independent chaperone mediated protein folding
I6G98_12940	COG4974	Belongs to the 'phage' integrase family
I6G98_13000	COG4695	Portal protein
I6G98_13090	COG5301	cellulose 1,4-beta-cellobiosidase activity
I6G98_13090	COG5301	cellulose 1,4-beta-cellobiosidase activity
I6G98_13155	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
I6G98_13175	COG3152	Membrane
I6G98_13180	COG3691	Protein conserved in bacteria
I6G98_13185	COG0589	response to stress
I6G98_13195	COG1494	fructose-1,6-bisphosphatase
I6G98_13205	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
I6G98_13220	COG1575	Belongs to the MenA family. Type 1 subfamily
I6G98_13235	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
I6G98_13240	COG1609	Transcriptional regulator
I6G98_13245	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
I6G98_13270	COG0626	cystathionine gamma-synthase activity
I6G98_13275	COG0527	aspartate kinase activity
I6G98_13275	COG0460	homoserine dehydrogenase
I6G98_13280	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
I6G98_13290	COG0697	spore germination
I6G98_13295	COG3738	Protein conserved in bacteria
I6G98_13300	COG0371	Dehydrogenase
I6G98_13305	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
I6G98_13310	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6G98_13310	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I6G98_13310	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6G98_13315	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6G98_13320	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6G98_13325	COG1882	Formate acetyltransferase
I6G98_13330	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
I6G98_13335	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6G98_13340	COG2207	Transcriptional regulator
I6G98_13345	COG2194	sulfuric ester hydrolase activity
I6G98_13360	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
I6G98_13380	COG4948	Mandelate Racemase Muconate Lactonizing
I6G98_13385	COG2271	Major facilitator Superfamily
I6G98_13390	COG0583	DNA-binding transcription factor activity
I6G98_13400	COG1309	transcriptional regulator
I6G98_13450	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
I6G98_13450	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
I6G98_13485	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
I6G98_13490	COG0250	Participates in transcription elongation, termination and antitermination
I6G98_13530	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
I6G98_13540	COG2104	thiamine diphosphate biosynthetic process
I6G98_13545	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
I6G98_13580	COG3068	Protein conserved in bacteria
I6G98_13595	COG3678	ATP-independent chaperone mediated protein folding
I6G98_13600	COG4191	Histidine kinase
I6G98_13605	COG2204	response regulator
I6G98_13610	COG0151	Belongs to the GarS family
I6G98_13640	COG0456	acetyltransferase
I6G98_13650	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
I6G98_13655	COG2224	Isocitrate lyase
I6G98_13670	COG1414	Transcriptional regulator
I6G98_13675	COG0646	methionine synthase
I6G98_13675	COG1410	methionine synthase
I6G98_13680	COG1283	sodium-dependent phosphate transmembrane transporter activity
I6G98_13735	COG3030	protein affecting phage T7 exclusion by the F plasmid
I6G98_13740	COG1027	Aspartate ammonia-lyase
I6G98_13745	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
I6G98_13760	COG1309	transcriptional regulator
I6G98_13815	COG3468	outer membrane autotransporter barrel domain protein
I6G98_13845	COG4771	TonB-dependent receptor
I6G98_13865	COG0629	single-stranded DNA binding
I6G98_13870	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
I6G98_13875	COG2315	Protein conserved in bacteria
I6G98_13880	COG0432	Pfam Uncharacterised protein family UPF0047
I6G98_13905	COG1448	Aminotransferase
I6G98_13910	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
I6G98_13915	COG0305	Participates in initiation and elongation during chromosome replication
I6G98_13920	COG0604	alcohol dehydrogenase
I6G98_13930	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
I6G98_13940	COG0735	belongs to the Fur family
I6G98_13945	COG3237	CsbD-like
I6G98_13950	COG0534	Mate efflux family protein
I6G98_13960	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
I6G98_13985	COG3547	Transposase (IS116 IS110 IS902 family)
I6G98_14020	COG3842	ATPase activity
I6G98_14025	COG2182	Extracellular solute-binding protein
I6G98_14030	COG1175	transmembrane transport
I6G98_14035	COG3833	ABC-type maltose transport systems, permease component
I6G98_14040	COG0477	Major facilitator Superfamily
I6G98_14040	COG2814	Major facilitator Superfamily
I6G98_14055	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6G98_14080	COG0527	aspartate kinase activity
I6G98_14090	COG1187	pseudouridine synthase activity
I6G98_14135	COG1509	lysine 2,3-aminomutase activity
I6G98_14145	COG5510	response to toxic substance
I6G98_14150	COG5510	response to toxic substance
I6G98_14155	COG2076	Multidrug Resistance protein
I6G98_14165	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
I6G98_14180	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
I6G98_14185	COG1053	succinate dehydrogenase
I6G98_14220	COG1511	domain protein
I6G98_14220	COG3264	Mechanosensitive ion channel
I6G98_14260	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
I6G98_14265	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
I6G98_14265	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
I6G98_14270	COG0802	atpase or kinase
I6G98_14275	COG0860	N-Acetylmuramoyl-L-alanine amidase
I6G98_14295	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
I6G98_14300	COG0330	HflC and HflK could
I6G98_14305	COG0330	HflC and HflK could
I6G98_14310	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
I6G98_14325	COG0557	exoribonuclease II activity
I6G98_14330	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
I6G98_14335	COG1414	Transcriptional regulator
I6G98_14340	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
I6G98_14350	COG2271	Major facilitator Superfamily
I6G98_14385	COG3766	membrane
I6G98_14390	COG5463	Belongs to the UPF0441 family
I6G98_14395	COG0754	glutathionylspermidine amidase activity
I6G98_14400	COG1960	acyl-CoA dehydrogenase activity
I6G98_14410	COG3650	response to hydrogen peroxide
I6G98_14415	COG1073	alpha beta
I6G98_14430	COG3037	sugar-specific permease SgaT UlaA
I6G98_14460	COG3477	response to acidic pH
I6G98_14480	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
I6G98_14490	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
I6G98_14500	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
I6G98_14505	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
I6G98_14510	COG4670	ketone body catabolic process
I6G98_14515	COG1024	Enoyl-CoA hydratase
I6G98_14530	COG1309	transcriptional regulator
I6G98_14535	COG3061	Opacity-associated protein A
I6G98_14540	COG0545	Peptidyl-prolyl cis-trans isomerase
I6G98_14545	COG1113	amino acid transport
I6G98_14555	COG0697	spore germination
I6G98_14560	COG0702	epimerase
I6G98_14565	COG1733	regulation of RNA biosynthetic process
I6G98_14570	COG0737	Belongs to the 5'-nucleotidase family
I6G98_14575	COG1218	3'(2'),5'-bisphosphate nucleotidase
I6G98_14580	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
I6G98_14590	COG1253	flavin adenine dinucleotide binding
I6G98_14600	COG0729	surface antigen
I6G98_14605	COG2911	Protein conserved in bacteria
I6G98_14610	COG2105	PFAM AIG2 family protein
I6G98_14615	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
I6G98_14620	COG1879	ABC-type sugar transport system periplasmic component
I6G98_14625	COG1129	ABC transporter
I6G98_14630	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6G98_14635	COG1172	Belongs to the binding-protein-dependent transport system permease family
I6G98_14645	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
I6G98_14655	COG0312	modulator of DNA gyrase
I6G98_14660	COG3783	Cytochrome b(562)
I6G98_14665	COG0602	queuosine metabolic process
I6G98_14670	COG1328	CTP reductase activity
I6G98_14675	COG0366	Alpha amylase catalytic
I6G98_14680	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6G98_14680	COG1263	PTS System
I6G98_14685	COG1609	Transcriptional regulator
I6G98_14695	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
I6G98_14700	COG0251	oxidation-reduction process
I6G98_14725	COG1028	Short-chain dehydrogenase reductase Sdr
I6G98_14730	COG1309	transcriptional regulator
I6G98_14735	COG2731	YhcH YjgK YiaL family protein
I6G98_14765	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
I6G98_14770	COG0456	acetyltransferase
I6G98_14775	COG4269	membrane
I6G98_14780	COG0525	valine-tRNA ligase activity
I6G98_14785	COG2927	DNA polymerase III (CHI subunit)
I6G98_14795	COG0795	lipopolysaccharide-transporting ATPase activity
I6G98_14800	COG0795	lipopolysaccharide-transporting ATPase activity
I6G98_14810	COG1609	Transcriptional regulator
I6G98_14815	COG2610	gluconate transmembrane transporter activity
I6G98_14820	COG1028	Short-chain dehydrogenase reductase Sdr
I6G98_14825	COG1063	alcohol dehydrogenase
I6G98_14830	COG3265	gluconokinase activity
I6G98_14835	COG1064	alcohol dehydrogenase
I6G98_14845	COG0582	viral genome integration into host DNA
I6G98_14885	COG1401	restriction endodeoxyribonuclease activity
I6G98_14910	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
I6G98_14915	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
I6G98_14920	COG0582	viral genome integration into host DNA
I6G98_14930	COG4974	Belongs to the 'phage' integrase family
I6G98_14955	COG3547	Transposase (IS116 IS110 IS902 family)
I6G98_14965	COG3539	Fimbrial protein
I6G98_14970	COG3539	Fimbrial protein
I6G98_14975	COG3539	Fimbrial protein
I6G98_14980	COG2610	gluconate transmembrane transporter activity
I6G98_14990	COG0246	Mannitol dehydrogenase
I6G98_14995	COG2186	Transcriptional regulator
I6G98_15025	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
I6G98_15030	COG0700	Nucleoside recognition
I6G98_15035	COG3366	ferrous iron transmembrane transporter activity
I6G98_15045	COG0477	Major facilitator Superfamily
I6G98_15065	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
I6G98_15070	COG2733	membrane
I6G98_15075	COG2814	Major facilitator Superfamily
I6G98_15085	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
I6G98_15090	COG5457	Domain of unknown function (DUF1127)
I6G98_15100	COG3547	Transposase (IS116 IS110 IS902 family)
I6G98_15110	COG0523	cobalamin synthesis protein
I6G98_15115	COG2879	small protein
I6G98_15120	COG1966	Carbon starvation protein
I6G98_15125	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I6G98_15130	COG2368	4-hydroxyphenylacetate
I6G98_15150	COG3971	2-oxopent-4-enoate hydratase activity
I6G98_15160	COG3384	dioxygenase
I6G98_15165	COG1012	belongs to the aldehyde dehydrogenase family
I6G98_15170	COG0179	Fumarylacetoacetate (FAA) hydrolase
I6G98_15175	COG1846	Transcriptional regulator
I6G98_15180	COG0840	transmembrane signaling receptor activity
I6G98_15185	COG2271	Major facilitator Superfamily
I6G98_15195	COG1802	Transcriptional regulator
I6G98_15200	COG1063	alcohol dehydrogenase
I6G98_15215	COG1484	DNA-dependent DNA replication
I6G98_15230	COG2966	Psort location CytoplasmicMembrane, score
I6G98_15235	COG2197	response regulator
I6G98_15240	COG2197	response regulator
I6G98_15245	COG4114	ferric iron reductase
I6G98_15275	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
I6G98_15280	COG0456	acetyltransferase
I6G98_15285	COG1011	Hydrolase
I6G98_15315	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
I6G98_15320	COG5532	Uncharacterized conserved protein (DUF2303)
I6G98_15345	COG3646	Phage regulatory protein
I6G98_15355	COG1846	Transcriptional regulator
I6G98_15365	COG4725	Belongs to the MT-A70-like family
I6G98_15375	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
I6G98_15385	COG1403	HNH endonuclease
I6G98_15450	COG0740	serine-type endopeptidase activity
I6G98_15525	COG5301	cellulose 1,4-beta-cellobiosidase activity
I6G98_15530	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
I6G98_15555	COG2823	Periplasmic or secreted lipoprotein
I6G98_15565	COG4667	esterase of the alpha-beta hydrolase superfamily
I6G98_15570	COG0084	hydrolase, TatD family'
I6G98_15575	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
I6G98_15580	COG1328	CTP reductase activity
I6G98_15615	COG3726	membrane protein affecting hemolysin expression
I6G98_15620	COG0560	Phosphoserine phosphatase
I6G98_15625	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
I6G98_15630	COG1056	cytidyltransferase-related domain
I6G98_15630	COG3172	ATPase kinase involved in NAD metabolism
I6G98_15635	COG0488	(ABC) transporter
I6G98_15640	COG0741	lytic transglycosylase activity
I6G98_15660	COG2207	Transcriptional regulator
I6G98_15660	COG3708	Transcriptional regulator
I6G98_15665	COG3045	CreA protein
I6G98_15670	COG0745	RESPONSE REGULATOR receiver
I6G98_15675	COG2205	protein histidine kinase activity
I6G98_15680	COG4452	Inner membrane protein CreD
I6G98_15685	COG0745	RESPONSE REGULATOR receiver
I6G98_15695	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
I6G98_15705	COG0460	homoserine dehydrogenase
I6G98_15705	COG0527	aspartate kinase activity
I6G98_15715	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
I6G98_15730	COG1115	amino acid carrier protein
I6G98_15735	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
I6G98_15740	COG0521	Mo-molybdopterin cofactor biosynthetic process
I6G98_15745	COG1584	GPR1 FUN34 yaaH family protein
I6G98_15750	COG4735	regulation of single-species biofilm formation
I6G98_15785	COG0583	DNA-binding transcription factor activity
I6G98_15810	COG0196	riboflavin kinase activity
I6G98_15825	COG1047	Peptidyl-prolyl cis-trans
I6G98_15845	COG0505	Belongs to the CarA family
I6G98_15850	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
I6G98_15905	COG0644	oxidoreductase
I6G98_15910	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
I6G98_15915	COG2271	Major facilitator Superfamily
I6G98_15930	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
I6G98_15955	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6G98_15960	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
I6G98_15965	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
I6G98_15970	COG0564	pseudouridine synthase activity
I6G98_15980	COG0417	DNA replication proofreading
I6G98_15985	COG0235	Class ii aldolase
I6G98_16000	COG4977	sequence-specific DNA binding
I6G98_16005	COG0586	Pfam SNARE associated Golgi protein
I6G98_16015	COG1178	ABC-type Fe3 transport system permease component
I6G98_16020	COG4143	(ABC) transporter
I6G98_16035	COG2814	Major facilitator Superfamily
I6G98_16050	COG0473	3-isopropylmalate dehydrogenase activity
I6G98_16065	COG0583	DNA-binding transcription factor activity
I6G98_16075	COG0028	Belongs to the TPP enzyme family
I6G98_16080	COG0440	acetolactate synthase activity
I6G98_16090	COG1609	Transcriptional regulator
I6G98_16105	COG3116	cell division
I6G98_16110	COG0768	penicillin binding
I6G98_16115	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
I6G98_16120	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
I6G98_16135	COG0772	Belongs to the SEDS family
I6G98_16150	COG1181	Belongs to the D-alanine--D-alanine ligase family
I6G98_16155	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
I6G98_16160	COG0849	cell division
I6G98_16165	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
I6G98_16185	COG0494	nUDIX hydrolase
I6G98_16200	COG0237	dephospho-CoA kinase activity
I6G98_16215	COG1459	type II secretion system
I6G98_16220	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
I6G98_16225	COG4969	Belongs to the N-Me-Phe pilin family
I6G98_16230	COG0157	Belongs to the NadC ModD family
I6G98_16235	COG3023	N-Acetylmuramoyl-L-alanine amidase
I6G98_16240	COG3725	Membrane protein required for beta-lactamase induction
I6G98_16245	COG1113	amino acid transport
I6G98_16250	COG2186	Transcriptional regulator
I6G98_16255	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
I6G98_16260	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6G98_16265	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
I6G98_16275	COG0582	viral genome integration into host DNA
I6G98_16320	COG1049	propionate catabolic process, 2-methylcitrate cycle
I6G98_16355	COG2842	Transposition protein
I6G98_16385	COG4396	Host-nuclease inhibitor protein Gam
I6G98_16435	COG5566	PFAM Mor transcription activator
I6G98_16460	COG0640	Transcriptional regulator
I6G98_16475	COG4373	Mu-like prophage FluMu protein gp28
I6G98_16480	COG4383	Mu-like prophage protein gp29
I6G98_16485	COG2369	cell adhesion
I6G98_16490	COG5005	Phage virion morphogenesis
I6G98_16495	COG4388	Caudovirus prohead serine protease
I6G98_16500	COG4397	Mu-like prophage major head subunit gpT
I6G98_16525	COG4386	tail sheath protein
I6G98_16535	COG4518	Phage tail assembly chaperone proteins, E, or 41 or 14
I6G98_16545	COG4228	DNA circulation
I6G98_16555	COG4384	Bacteriophage Mu Gp45 protein
I6G98_16560	COG4381	Mu-like prophage protein gp46
I6G98_16565	COG3299	homolog of phage Mu protein gp47
I6G98_16575	COG5301	cellulose 1,4-beta-cellobiosidase activity
I6G98_16595	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
I6G98_16620	COG2132	Multicopper oxidase
I6G98_16625	COG4993	Dehydrogenase
I6G98_16630	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
I6G98_16635	COG0288	reversible hydration of carbon dioxide
I6G98_16640	COG1131	(ABC) transporter
I6G98_16645	COG0842	Transport permease protein
I6G98_16650	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6G98_16655	COG0726	polysaccharide deacetylase
I6G98_16665	COG5464	transposase or invertase
I6G98_16680	COG3539	Fimbrial protein
I6G98_16690	COG3539	Fimbrial protein
I6G98_16695	COG3539	Fimbrial protein
I6G98_16715	COG3121	Chaperone
I6G98_16720	COG3539	Fimbrial protein
I6G98_16725	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
I6G98_16730	COG0617	tRNA 3'-terminal CCA addition
I6G98_16740	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
I6G98_16750	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
I6G98_16755	COG1643	Atp-dependent helicase
I6G98_16760	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
I6G98_16765	COG4774	siderophore transport
I6G98_16770	COG1120	ATPase activity
I6G98_16775	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I6G98_16780	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6G98_16805	COG2860	membrane
I6G98_16810	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
I6G98_16825	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
I6G98_16830	COG3835	regulator
I6G98_16850	COG0024	Methionine aminopeptidase
I6G98_16875	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
I6G98_16880	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
I6G98_16885	COG0575	Belongs to the CDS family
I6G98_16890	COG0750	zinc metalloprotease
I6G98_16900	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
I6G98_16905	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
I6G98_16930	COG0587	DNA-directed DNA polymerase activity
I6G98_16940	COG1982	Orn Lys Arg decarboxylase major
I6G98_16945	COG0346	lactoylglutathione lyase activity
I6G98_16955	COG4568	rho-dependent transcription termination
I6G98_16965	COG4681	YaeQ
I6G98_16970	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
I6G98_16975	COG3015	lipoprotein NlpE involved in copper resistance
I6G98_16990	COG1720	tRNA m6t6A37 methyltransferase activity
I6G98_17000	COG1464	Belongs to the NlpA lipoprotein family
I6G98_17005	COG2011	ABC-type metal ion transport system permease component
I6G98_17010	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
I6G98_17015	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
I6G98_17050	COG0656	L-ascorbic acid biosynthetic process
I6G98_17065	COG2226	methyltransferase
I6G98_17070	COG1388	LysM domain
I6G98_17070	COG0741	lytic transglycosylase activity
I6G98_17080	COG2226	methyltransferase
I6G98_17090	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I6G98_17110	COG4104	PAAR repeat-containing protein
I6G98_17115	COG3157	Type VI secretion system effector, Hcp
I6G98_17230	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I6G98_17240	COG1960	acyl-CoA dehydrogenase activity
I6G98_17250	COG0121	glutamine amidotransferase
I6G98_17255	COG3034	peptidoglycan biosynthetic process
I6G98_17260	COG3041	Addiction module toxin RelE StbE family
I6G98_17265	COG3077	Addiction module antitoxin, RelB DinJ family
I6G98_17270	COG0791	NLP P60 protein
I6G98_17300	COG1987	bacterial-type flagellum assembly
I6G98_17325	COG1677	Flagellar hook-basal body complex protein FliE
I6G98_17335	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
I6G98_17355	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
I6G98_17385	COG1815	bacterial-type flagellum-dependent cell motility
I6G98_17390	COG1558	bacterial-type flagellum-dependent cell motility
I6G98_17400	COG1749	Flagellar hook protein flgE
I6G98_17405	COG4787	bacterial-type flagellum-dependent cell motility
I6G98_17410	COG4786	Flagellar basal body rod
I6G98_17435	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
I6G98_17450	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
I6G98_17455	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
I6G98_17480	COG1191	sigma factor activity
I6G98_17485	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
I6G98_17495	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I6G98_17500	COG0454	-acetyltransferase
I6G98_17505	COG1690	Belongs to the RtcB family
I6G98_17510	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
I6G98_17515	COG2195	Cleaves the N-terminal amino acid of tripeptides
I6G98_17535	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
I6G98_17560	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
I6G98_17565	COG1529	Aldehyde oxidase and xanthine dehydrogenase
I6G98_17570	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
I6G98_17575	COG2080	2 iron, 2 sulfur cluster binding
I6G98_17610	COG0727	PFAM Uncharacterised protein family (UPF0153)
I6G98_17615	COG3121	Chaperone
I6G98_17625	COG3188	usher protein
I6G98_17675	COG1388	LysM domain
I6G98_17680	COG3708	Transcriptional regulator
I6G98_17680	COG2207	Transcriptional regulator
I6G98_17685	COG0656	L-ascorbic acid biosynthetic process
I6G98_17690	COG3059	membrane
I6G98_17705	COG2207	Transcriptional regulator
I6G98_17710	COG0247	lactate metabolic process
I6G98_17715	COG1139	Iron-sulfur cluster binding protein
I6G98_17720	COG1556	Lactate utilization protein
I6G98_17745	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I6G98_17760	COG3385	transposase activity
I6G98_17775	COG0110	maltose O-acetyltransferase activity
I6G98_17780	COG2223	nitrite transmembrane transporter activity
I6G98_17790	COG3250	beta-galactosidase activity
I6G98_17795	COG1609	Transcriptional regulator
I6G98_17800	COG1414	Transcriptional regulator
I6G98_17835	COG2814	Major facilitator Superfamily
I6G98_17840	COG3122	Protein conserved in bacteria
I6G98_17860	COG3547	Transposase (IS116 IS110 IS902 family)
I6G98_17875	COG1215	transferase activity, transferring glycosyl groups
I6G98_17880	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
I6G98_17890	COG4521	taurine ABC transporter
I6G98_17900	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6G98_17905	COG2175	clavaminate synthase activity
I6G98_17910	COG0113	porphobilinogen synthase activity
I6G98_17915	COG3468	outer membrane autotransporter barrel domain protein
I6G98_17925	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I6G98_17950	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
I6G98_17970	COG1181	Belongs to the D-alanine--D-alanine ligase family
I6G98_17990	COG1785	Belongs to the alkaline phosphatase family
I6G98_18005	COG3547	Transposase (IS116 IS110 IS902 family)
I6G98_18015	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
I6G98_18035	COG4126	flavin adenine dinucleotide binding
I6G98_18060	COG1940	carbohydrate kinase activity
I6G98_18065	COG2814	Major facilitator Superfamily
I6G98_18070	COG0419	ATPase involved in DNA repair
I6G98_18075	COG0420	3'-5' exonuclease activity
I6G98_18080	COG0745	RESPONSE REGULATOR receiver
I6G98_18085	COG5002	protein histidine kinase activity
I6G98_18090	COG1114	Component of the transport system for branched-chain amino acids
I6G98_18095	COG1113	amino acid transport
I6G98_18120	COG1862	Preprotein translocase
I6G98_18125	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I6G98_18130	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
I6G98_18135	COG1403	HNH endonuclease
I6G98_18140	COG3248	Nucleoside-binding outer membrane protein
I6G98_18145	COG4238	major outer membrane lipoprotein
I6G98_18155	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I6G98_18155	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
I6G98_18170	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
I6G98_18175	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
I6G98_18180	COG0667	Aldo Keto reductase
I6G98_18190	COG0142	geranyltranstransferase activity
I6G98_18205	COG0693	protein deglycase activity
I6G98_18210	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
I6G98_18220	COG2814	Major facilitator Superfamily
I6G98_18245	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
I6G98_18250	COG1845	cytochrome c oxidase, subunit III
I6G98_18255	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
I6G98_18260	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
I6G98_18265	COG2223	nitrite transmembrane transporter activity
I6G98_18270	COG3056	Lipoprotein
I6G98_18275	COG0271	Belongs to the BolA IbaG family
I6G98_18295	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
I6G98_18300	COG0776	regulation of translation
I6G98_18305	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
I6G98_18310	COG1555	photosystem II stabilization
I6G98_18315	COG0824	Thioesterase
I6G98_18325	COG4533	DNA binding
I6G98_18335	COG1522	sequence-specific DNA binding
I6G98_18340	COG1132	(ABC) transporter
I6G98_18345	COG1132	(ABC) transporter
I6G98_18350	COG0347	Belongs to the P(II) protein family
I6G98_18375	COG3126	Type III secretion system lipoprotein chaperone (YscW)
I6G98_18380	COG3695	enzyme binding
I6G98_18390	COG5507	3-demethylubiquinone-9 3-methyltransferase
I6G98_18395	COG4943	cyclic-guanylate-specific phosphodiesterase activity
I6G98_18405	COG0110	maltose O-acetyltransferase activity
I6G98_18425	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6G98_18430	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6G98_18435	COG1309	transcriptional regulator
I6G98_18440	COG3264	Mechanosensitive ion channel
I6G98_18440	COG1196	nuclear chromosome segregation
I6G98_18450	COG3923	Primosomal replication protein n
I6G98_18455	COG2832	Protein of unknown function (DUF454)
I6G98_18465	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
I6G98_18500	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
I6G98_18505	COG4651	solute:proton antiporter activity
I6G98_18505	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I6G98_18510	COG2223	nitrite transmembrane transporter activity
I6G98_18515	COG0737	Belongs to the 5'-nucleotidase family
I6G98_18520	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
I6G98_18525	COG3735	TraB family
I6G98_18530	COG3093	addiction module antidote protein HigA
I6G98_18535	COG2217	Heavy metal translocating P-type atpase
I6G98_18545	COG0531	amino acid
I6G98_18550	COG0789	Transcriptional regulator
I6G98_18555	COG1585	Membrane protein implicated in regulation of membrane protease activity
I6G98_18560	COG0330	HflC and HflK could
I6G98_18565	COG4619	ABC transporter
I6G98_18570	COG0390	transport system, permease component
I6G98_18575	COG3118	belongs to the thioredoxin family
I6G98_18580	COG0300	oxidoreductase activity
I6G98_18585	COG2755	lipolytic protein G-D-S-L family
I6G98_18590	COG4181	ATPase activity
I6G98_18595	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
I6G98_18600	COG3209	COG3209 Rhs family protein
I6G98_18620	COG0583	DNA-binding transcription factor activity
I6G98_18635	COG1414	Transcriptional regulator
I6G98_18640	COG3960	tartronate-semialdehyde synthase activity
I6G98_18645	COG3622	Belongs to the hyi family
I6G98_18650	COG2084	Dehydrogenase
I6G98_18660	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
I6G98_18665	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
I6G98_18685	COG0549	Belongs to the carbamate kinase family
I6G98_18690	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
I6G98_18695	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
I6G98_18705	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
I6G98_18715	COG1988	membrane-bound metal-dependent
I6G98_18720	COG2501	S4 domain
I6G98_18730	COG3539	Fimbrial protein
I6G98_18735	COG3121	Chaperone
I6G98_18765	COG2207	Transcriptional regulator
I6G98_18790	COG1215	transferase activity, transferring glycosyl groups
I6G98_18805	COG5002	protein histidine kinase activity
I6G98_18810	COG0745	RESPONSE REGULATOR receiver
I6G98_18815	COG1538	Outer membrane efflux protein
I6G98_18820	COG5569	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6G98_18825	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6G98_18830	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
I6G98_18835	COG1113	amino acid transport
I6G98_18840	COG0668	transmembrane transport
I6G98_18845	COG0778	Nitroreductase
I6G98_18850	COG2315	Protein conserved in bacteria
I6G98_18885	COG2977	Belongs to the P-Pant transferase superfamily
I6G98_18890	COG4771	TonB-dependent receptor
I6G98_18895	COG2382	esterase
I6G98_18900	COG3251	PFAM MbtH domain protein
I6G98_18905	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
I6G98_18905	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
I6G98_18910	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
I6G98_18915	COG1120	ATPase activity
I6G98_18920	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6G98_18925	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
I6G98_18935	COG4592	Periplasmic binding protein
I6G98_18940	COG1169	isochorismate synthase
I6G98_18945	COG1021	2,3-dihydroxybenzoate-AMP ligase
I6G98_18950	COG3433	isochorismatase activity
I6G98_18950	COG1535	isochorismatase
I6G98_18955	COG1028	Short-chain dehydrogenase reductase Sdr
I6G98_18960	COG2050	protein possibly involved in aromatic compounds catabolism
I6G98_18965	COG1966	Carbon starvation protein
I6G98_18970	COG2879	small protein
I6G98_18975	COG0371	Dehydrogenase
I6G98_18980	COG0436	Aminotransferase
I6G98_19000	COG3969	phosphoadenosine phosphosulfate
I6G98_19005	COG0583	DNA-binding transcription factor activity
I6G98_19010	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
I6G98_19015	COG0450	alkyl hydroperoxide reductase
I6G98_19020	COG3634	alkyl hydroperoxide reductase activity
I6G98_19025	COG0589	response to stress
I6G98_19030	COG1063	alcohol dehydrogenase
I6G98_19035	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
I6G98_19040	COG3719	Belongs to the RNase T2 family
I6G98_19045	COG0471	metal ion transport
I6G98_19070	COG3051	citrate lyase alpha subunit
I6G98_19075	COG2301	Belongs to the HpcH HpaI aldolase family
I6G98_19085	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
I6G98_19090	COG3290	protein histidine kinase activity
I6G98_19095	COG4565	transcriptional regulatory protein
I6G98_19100	COG3069	C4-dicarboxylate transmembrane transporter activity
I6G98_19120	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
I6G98_19125	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
I6G98_19135	COG0583	DNA-binding transcription factor activity
I6G98_19150	COG1686	Belongs to the peptidase S11 family
I6G98_19155	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
I6G98_19160	COG0772	Belongs to the SEDS family
I6G98_19165	COG0768	penicillin binding
I6G98_19175	COG0799	negative regulation of ribosome biogenesis
I6G98_19180	COG0406	alpha-ribazole phosphatase activity
I6G98_19190	COG1466	dna polymerase III delta subunit
I6G98_19205	COG2888	peptidyl-tyrosine sulfation
I6G98_19210	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
I6G98_19220	COG2214	Heat shock protein DnaJ domain protein
I6G98_19225	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
I6G98_19235	COG2214	Heat shock protein DnaJ domain protein
I6G98_19240	COG0443	Heat shock 70 kDa protein
I6G98_19250	COG1126	abc transporter atp-binding protein
I6G98_19255	COG0765	amino acid transport
I6G98_19260	COG0765	amino acid transport
I6G98_19265	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6G98_19275	COG0815	Transfers the fatty acyl group on membrane lipoproteins
I6G98_19280	COG4535	Mg2 and Co2 transporter CorC
I6G98_19290	COG1702	phosphate starvation-inducible protein PhoH
I6G98_19300	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
I6G98_19340	COG0367	asparagine synthase
I6G98_19345	COG0647	UMP catabolic process
I6G98_19350	COG1846	Transcriptional regulator
I6G98_19350	COG1940	carbohydrate kinase activity
I6G98_19355	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
I6G98_19365	COG2190	(PTS) system
I6G98_19365	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6G98_19365	COG1263	PTS System
I6G98_19385	COG0735	belongs to the Fur family
I6G98_19395	COG0716	FMN binding
I6G98_19405	COG0596	Alpha beta hydrolase
I6G98_19410	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
I6G98_19415	COG0033	Phosphoglucomutase
I6G98_19420	COG0531	amino acid
I6G98_19425	COG1982	Orn Lys Arg decarboxylase major
I6G98_19435	COG0745	RESPONSE REGULATOR receiver
I6G98_19440	COG2205	protein histidine kinase activity
I6G98_19475	COG3209	COG3209 Rhs family protein
I6G98_19475	COG3209	COG3209 Rhs family protein
I6G98_19505	COG3272	Protein of unknown function (DUF1722)
I6G98_19510	COG0415	Belongs to the DNA photolyase family
I6G98_19520	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
I6G98_19525	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
I6G98_19530	COG1984	allophanate hydrolase subunit 2
I6G98_19545	COG3180	Ammonia monooxygenase
I6G98_19550	COG3539	Fimbrial protein
I6G98_19555	COG3121	Chaperone
I6G98_19560	COG3188	usher protein
I6G98_19565	COG3539	Fimbrial protein
I6G98_19570	COG0372	Belongs to the citrate synthase family
I6G98_19580	COG2009	succinate dehydrogenase
I6G98_19585	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
I6G98_19590	COG1053	succinate dehydrogenase
I6G98_19595	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
I6G98_19600	COG0567	Dehydrogenase, E1 component
I6G98_19605	COG0508	dehydrogenase complex catalyzes the overall conversion of
I6G98_19615	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
I6G98_19620	COG2188	Transcriptional regulator
I6G98_19625	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6G98_19625	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6G98_19625	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
I6G98_19640	COG1271	oxidase subunit
I6G98_19645	COG1294	oxidase, subunit
I6G98_19650	COG4890	Cyd operon protein YbgT
I6G98_19655	COG3790	cyd operon protein YbgE
I6G98_19660	COG0824	Thioesterase
I6G98_19665	COG0811	peptide transport
I6G98_19670	COG0848	biopolymer transport protein
I6G98_19675	COG3064	Membrane
I6G98_19685	COG2885	chlorophyll binding
I6G98_19690	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
I6G98_19730	COG3201	nicotinamide mononucleotide transporter
I6G98_19735	COG1230	cation diffusion facilitator family transporter
I6G98_19745	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I6G98_19755	COG2017	converts alpha-aldose to the beta-anomer
I6G98_19765	COG1085	galactose-1-phosphate uridylyltransferase
I6G98_19770	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
I6G98_19775	COG1119	ATPase activity
I6G98_19780	COG3585	molybdate ion transport
I6G98_19780	COG2005	Transcriptional regulator
I6G98_19790	COG0725	ABC transporter, periplasmic molybdate-binding protein
I6G98_19795	COG4149	molybdate abc transporter
I6G98_19805	COG0561	phosphatase activity
I6G98_19820	COG0582	viral genome integration into host DNA
I6G98_19845	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
I6G98_19880	COG1396	sequence-specific DNA binding
I6G98_19895	COG3756	Protein conserved in bacteria
I6G98_19900	COG1484	DNA-dependent DNA replication
I6G98_19915	COG1636	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
I6G98_19970	COG3772	lysozyme
I6G98_20000	COG4695	Portal protein
I6G98_20095	COG3299	homolog of phage Mu protein gp47
I6G98_20100	COG3778	Protein conserved in bacteria
I6G98_20115	COG5301	cellulose 1,4-beta-cellobiosidase activity
I6G98_20150	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
I6G98_20175	COG2828	Protein conserved in bacteria
I6G98_20180	COG0471	metal ion transport
I6G98_20190	COG4677	pectinesterase activity
I6G98_20195	COG1881	PFAM PEBP family protein
I6G98_20200	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
I6G98_20215	COG2226	methyltransferase
I6G98_20220	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
I6G98_20230	COG0391	Required for morphogenesis under gluconeogenic growth conditions
I6G98_20240	COG0521	Mo-molybdopterin cofactor biosynthetic process
I6G98_20250	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
I6G98_20255	COG0314	molybdopterin synthase activity
I6G98_20260	COG0670	Belongs to the BI1 family
I6G98_20270	COG0392	lysyltransferase activity
I6G98_20275	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
I6G98_20280	COG3568	Endonuclease Exonuclease Phosphatase
I6G98_20290	COG0842	Transport permease protein
I6G98_20295	COG0842	Transport permease protein
I6G98_20300	COG1131	(ABC) transporter
I6G98_20310	COG1309	transcriptional regulator
I6G98_20315	COG0513	Belongs to the DEAD box helicase family
I6G98_20320	COG3236	hydrolase activity, hydrolyzing N-glycosyl compounds
I6G98_20325	COG1199	ATP-dependent helicase activity
I6G98_20330	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I6G98_20335	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
I6G98_20345	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
I6G98_20355	COG4774	siderophore transport
I6G98_20370	COG0668	transmembrane transport
I6G98_20375	COG1126	abc transporter atp-binding protein
I6G98_20380	COG0765	amino acid transport
I6G98_20385	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6G98_20395	COG5006	permease, DMT superfamily
I6G98_20405	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
I6G98_20410	COG2194	sulfuric ester hydrolase activity
I6G98_20420	COG1321	iron dependent repressor
I6G98_20425	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
I6G98_20430	COG1376	ErfK ybiS ycfS ynhG family protein
I6G98_20435	COG0488	(ABC) transporter
I6G98_20445	COG0561	phosphatase activity
I6G98_20450	COG1882	Formate acetyltransferase
I6G98_20455	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
I6G98_20460	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
I6G98_20465	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
I6G98_20470	COG0303	'Molybdopterin
I6G98_20475	COG1446	asparaginase
I6G98_20500	COG2200	EAL domain
I6G98_20505	COG2199	diguanylate cyclase activity
I6G98_20520	COG2133	pyrroloquinoline quinone binding
I6G98_20525	COG0625	glutathione transferase activity
I6G98_20530	COG1686	Belongs to the peptidase S11 family
I6G98_20535	COG1349	DNA-binding transcription factor activity
I6G98_20540	COG0671	phosphoesterase, PA-phosphatase related
I6G98_20545	COG2814	Major facilitator Superfamily
I6G98_20555	COG0561	phosphatase activity
I6G98_20560	COG0738	Major facilitator superfamily
I6G98_20565	COG3226	Transcriptional regulator
I6G98_20580	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
I6G98_20590	COG0778	Nitroreductase
I6G98_20620	COG3842	ATPase activity
I6G98_20625	COG1176	ABC-type spermidine putrescine transport system, permease component I
I6G98_20630	COG1177	transmembrane transport
I6G98_20645	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6G98_20650	COG4160	amino acid transport
I6G98_20655	COG4215	(ABC) transporter
I6G98_20660	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
I6G98_20665	COG1126	abc transporter atp-binding protein
I6G98_20680	COG3023	N-Acetylmuramoyl-L-alanine amidase
I6G98_20685	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
I6G98_20690	COG0702	epimerase
I6G98_20695	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
I6G98_20700	COG0028	Belongs to the TPP enzyme family
I6G98_20705	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6G98_20715	COG2431	L-lysine efflux transmembrane transporter activity
I6G98_20725	COG3593	DNA synthesis involved in DNA repair
I6G98_20730	COG2990	Protein conserved in bacteria
I6G98_20735	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
I6G98_20740	COG1136	(ABC) transporter
I6G98_20740	COG0577	efflux transmembrane transporter activity
I6G98_20745	COG1278	Cold shock
I6G98_20755	COG0542	response to heat
I6G98_20775	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
I6G98_20780	COG4988	ABC transporter
I6G98_20785	COG0492	ferredoxin-NADP+ reductase activity
I6G98_20790	COG1522	sequence-specific DNA binding
I6G98_20805	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
I6G98_20815	COG0243	molybdopterin cofactor binding
I6G98_20820	COG0437	4 iron, 4 sulfur cluster binding
I6G98_20825	COG3302	dmso reductase anchor subunit
I6G98_20830	COG1335	isochorismatase
I6G98_20840	COG0531	amino acid
I6G98_20845	COG0583	DNA-binding transcription factor activity
I6G98_20850	COG2249	NAD(P)H dehydrogenase (quinone) activity
I6G98_20855	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
I6G98_20860	COG1882	Formate acetyltransferase
I6G98_20865	COG2116	formate transmembrane transporter activity
I6G98_20870	COG1944	ATP diphosphatase activity
I6G98_20875	COG2323	membrane
I6G98_20890	COG0501	Belongs to the peptidase M48B family
I6G98_20900	COG0539	negative regulation of cytoplasmic translation
I6G98_20910	COG2333	competence protein COMEC
I6G98_20910	COG0658	competence protein
I6G98_20915	COG1132	(ABC) transporter
I6G98_20925	COG3214	Protein conserved in bacteria
I6G98_20940	COG3173	Aminoglycoside phosphotransferase
I6G98_20945	COG1434	Gram-negative-bacterium-type cell wall biogenesis
I6G98_20950	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
I6G98_20960	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
I6G98_20970	COG2989	Protein conserved in bacteria
I6G98_20975	COG3108	Peptidase M15
I6G98_20980	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
I6G98_20985	COG1448	Aminotransferase
I6G98_21005	COG0308	aminopeptidase N
I6G98_21015	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
I6G98_21025	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
I6G98_21030	COG0431	NADPH-dependent FMN reductase
I6G98_21035	COG3539	Fimbrial protein
I6G98_21040	COG3121	Chaperone
I6G98_21045	COG3188	usher protein
I6G98_21050	COG3539	Fimbrial protein
I6G98_21055	COG3539	Fimbrial protein
I6G98_21080	COG3217	Mosc domain protein beta barrel domain protein
I6G98_21080	COG0633	Ferredoxin
I6G98_21090	COG0488	(ABC) transporter
I6G98_21095	COG2995	paraquat-inducible protein a
I6G98_21100	COG3008	intermembrane lipid transfer
I6G98_21100	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
I6G98_21105	COG3009	Protein conserved in bacteria
I6G98_21110	COG3130	regulation of translation
I6G98_21120	COG1067	ATP-dependent peptidase activity
I6G98_21130	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
I6G98_21130	COG2885	chlorophyll binding
I6G98_21140	COG3070	regulator of competence-specific genes
I6G98_21145	COG1289	transmembrane transporter activity
I6G98_21150	COG3304	Inner membrane component domain
I6G98_21155	COG0210	DNA helicase
I6G98_21170	COG1832	CoA-binding protein
I6G98_21185	COG1254	Belongs to the acylphosphatase family
I6G98_21190	COG2920	part of a sulfur-relay system
I6G98_21195	COG0670	Belongs to the BI1 family
I6G98_21205	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
I6G98_21210	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
I6G98_21215	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
I6G98_21220	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
I6G98_21225	COG1999	signal sequence binding
I6G98_21230	COG1773	rubredoxin
I6G98_21235	COG1271	oxidase subunit
I6G98_21240	COG1294	oxidase, subunit
I6G98_21255	COG3206	protein involved in exopolysaccharide biosynthesis
I6G98_21255	COG0489	protein tyrosine kinase activity
I6G98_21260	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
I6G98_21265	COG1596	polysaccharide export
I6G98_21270	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6G98_21290	COG1278	Cold shock
I6G98_21295	COG1278	Cold shock
I6G98_21315	COG0348	domain, Protein
I6G98_21320	COG0784	Response regulator, receiver
I6G98_21320	COG2198	Histidine kinase
I6G98_21320	COG2205	protein histidine kinase activity
I6G98_21325	COG1879	ABC-type sugar transport system periplasmic component
I6G98_21330	COG0745	RESPONSE REGULATOR receiver
I6G98_21335	COG3005	denitrification pathway
I6G98_21340	COG0243	molybdopterin cofactor binding
I6G98_21380	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
I6G98_21450	COG1560	Kdo2-lipid A biosynthetic process
I6G98_21460	COG2353	YceI-like domain
I6G98_21465	COG3038	cytochrome b561
I6G98_21500	COG2999	glutathione oxidoreductase activity
I6G98_21515	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6G98_21525	COG0673	inositol 2-dehydrogenase activity
I6G98_21530	COG0728	peptidoglycan biosynthetic process
I6G98_21535	COG3418	PFAM FlgN family protein
I6G98_21540	COG2747	anti-sigma28 factor FlgM
I6G98_21545	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
I6G98_21550	COG1815	bacterial-type flagellum-dependent cell motility
I6G98_21555	COG1558	bacterial-type flagellum-dependent cell motility
I6G98_21560	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
I6G98_21565	COG1749	Flagellar hook protein flgE
I6G98_21570	COG4787	bacterial-type flagellum-dependent cell motility
I6G98_21575	COG4786	Flagellar basal body rod
I6G98_21590	COG1705	Flagellar rod assembly protein muramidase FlgJ
I6G98_21590	COG3951	Flagellar rod assembly protein muramidase FlgJ
I6G98_21595	COG1256	bacterial-type flagellum assembly
I6G98_21600	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
I6G98_21605	COG1530	ribonuclease E activity
I6G98_21610	COG0564	pseudouridine synthase activity
I6G98_21615	COG0424	maF-like protein
I6G98_21620	COG1399	metal-binding, possibly nucleic acid-binding protein
I6G98_21640	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
I6G98_21645	COG1028	Short-chain dehydrogenase reductase Sdr
I6G98_21655	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
I6G98_21660	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
I6G98_21665	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
I6G98_21675	COG0470	DNA polymerase III
I6G98_21680	COG0084	hydrolase, TatD family'
I6G98_21685	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6G98_21685	COG1263	PTS System
I6G98_21690	COG4773	Receptor
I6G98_21695	COG0537	adenosine 5'-monophosphoramidase activity
I6G98_21700	COG5633	Lipoprotein
I6G98_21705	COG3417	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)
I6G98_21725	COG1252	NADH dehydrogenase
I6G98_21730	COG3134	Outer membrane lipoprotein
I6G98_21735	COG1309	transcriptional regulator
I6G98_21745	COG1376	ErfK ybiS ycfS ynhG family protein
I6G98_21745	COG1388	LysM domain
I6G98_21750	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
I6G98_21755	COG4763	Acyl-transferase
I6G98_21760	COG4591	ABC-type transport system involved in lipoprotein release permease component
I6G98_21770	COG4591	ABC-type transport system involved in lipoprotein release permease component
I6G98_21780	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
I6G98_21785	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
I6G98_21790	COG1177	transmembrane transport
I6G98_21810	COG2850	peptidyl-arginine hydroxylation
I6G98_21815	COG2205	protein histidine kinase activity
I6G98_21825	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
I6G98_21845	COG1187	pseudouridine synthase activity
I6G98_21850	COG0538	isocitrate dehydrogenase activity
I6G98_21875	COG5562	phage envelope protein
I6G98_21880	COG0789	Transcriptional regulator
I6G98_21980	COG2894	cell division
I6G98_22015	COG0179	Fumarylacetoacetate (FAA) hydrolase
I6G98_22035	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
I6G98_22040	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
I6G98_22045	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
I6G98_22060	COG2719	SpoVR family
I6G98_22070	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
I6G98_22080	COG1619	proteins homologs of microcin C7 resistance protein MccF
I6G98_22090	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
I6G98_22110	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
I6G98_22110	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I6G98_22110	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6G98_22115	COG1461	Dihydroxyacetone kinase
I6G98_22120	COG2376	Dihydroxyacetone kinase
I6G98_22125	COG3284	Transcriptional regulator
I6G98_22130	COG3468	outer membrane autotransporter barrel domain protein
I6G98_22140	COG0012	GTP binding
I6G98_22155	COG0659	secondary active sulfate transmembrane transporter activity
I6G98_22160	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
I6G98_22185	COG2890	protein-(glutamine-N5) methyltransferase activity
I6G98_22190	COG3094	Invasion gene expression up-regulator, SirB
I6G98_22195	COG2912	Transglutaminase-like superfamily
I6G98_22215	COG0387	Pfam Sodium calcium exchanger
I6G98_22220	COG4572	Cation transport regulator
I6G98_22225	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
I6G98_22230	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
I6G98_22235	COG4932	domain protein
I6G98_22240	COG2197	response regulator
I6G98_22245	COG3850	Histidine kinase
I6G98_22250	COG2223	nitrite transmembrane transporter activity
I6G98_22255	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
I6G98_22260	COG1140	nitrate reductase beta subunit
I6G98_22265	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
I6G98_22270	COG2181	nitrate reductase activity
I6G98_22290	COG0788	formyltetrahydrofolate deformylase activity
I6G98_22305	COG0745	RESPONSE REGULATOR receiver
I6G98_22310	COG1210	Utp--glucose-1-phosphate uridylyltransferase
I6G98_22320	COG1435	thymidine kinase activity
I6G98_22325	COG3385	transposase activity
I6G98_22330	COG1454	alcohol dehydrogenase
I6G98_22330	COG1012	belongs to the aldehyde dehydrogenase family
I6G98_22335	COG2095	MarC family integral membrane protein
I6G98_22360	COG0601	transmembrane transport
I6G98_22365	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
I6G98_22370	COG0444	Belongs to the ABC transporter superfamily
I6G98_22375	COG4608	Belongs to the ABC transporter superfamily
I6G98_22395	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
I6G98_22400	COG2350	Protein conserved in bacteria
I6G98_22410	COG1607	acyl-coa hydrolase
I6G98_22430	COG3047	cAMP biosynthetic process
I6G98_22435	COG3685	Protein conserved in bacteria
I6G98_22440	COG3685	Protein conserved in bacteria
I6G98_22445	COG3729	General stress protein
I6G98_22450	COG0159	tryptophan synthase activity
I6G98_22460	COG0135	phosphoribosylanthranilate isomerase activity
I6G98_22460	COG0134	indole-3-glycerol-phosphate synthase activity
I6G98_22465	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
I6G98_22465	COG0512	Glutamine amidotransferase of anthranilate synthase
I6G98_22470	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
I6G98_22480	COG0613	PHP domain protein
I6G98_22485	COG0009	L-threonylcarbamoyladenylate synthase
I6G98_22490	COG1187	pseudouridine synthase activity
I6G98_22495	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
I6G98_22500	COG1028	Short-chain dehydrogenase reductase Sdr
I6G98_22505	COG0616	signal peptide processing
I6G98_22515	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I6G98_22520	COG0583	DNA-binding transcription factor activity
I6G98_22540	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
I6G98_22550	COG0671	phosphoesterase, PA-phosphatase related
I6G98_22555	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
I6G98_22560	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
I6G98_22570	COG0023	Translation Initiation Factor
I6G98_22580	COG1349	DNA-binding transcription factor activity
I6G98_22590	COG5001	Diguanylate cyclase
I6G98_22605	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I6G98_22605	COG4950	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I6G98_22610	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
I6G98_22615	COG2852	Protein conserved in bacteria
I6G98_22620	COG4172	Belongs to the ABC transporter superfamily
I6G98_22625	COG4172	Belongs to the ABC transporter superfamily
I6G98_22630	COG4171	peptide transport system, permease
I6G98_22635	COG4168	peptide transport system, permease
I6G98_22640	COG4166	transmembrane transport
I6G98_22650	COG0531	amino acid
I6G98_22660	COG0174	glutamine synthetase
I6G98_22665	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
I6G98_22670	COG1396	sequence-specific DNA binding
I6G98_22670	COG1917	Cupin 2, conserved barrel domain protein
I6G98_22675	COG1012	belongs to the aldehyde dehydrogenase family
I6G98_22680	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
I6G98_22685	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
I6G98_22690	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
I6G98_22695	COG1842	Phage shock protein A
I6G98_22705	COG1983	PspC domain protein
I6G98_22715	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
I6G98_22720	COG0366	Alpha amylase catalytic
I6G98_22730	COG1175	transmembrane transport
I6G98_22735	COG0395	ABC-type sugar transport system, permease component
I6G98_22745	COG1082	Xylose isomerase domain protein TIM barrel
I6G98_22750	COG0673	inositol 2-dehydrogenase activity
I6G98_22755	COG1554	hydrolase, family 65, central catalytic
I6G98_22760	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6G98_22765	COG3842	ATPase activity
I6G98_22775	COG1609	Transcriptional regulator
I6G98_22780	COG3106	COG3106 Predicted ATPase
I6G98_22790	COG3283	Transcriptional regulator of aromatic amino acids metabolism
I6G98_22795	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
I6G98_22800	COG4948	Mandelate Racemase Muconate Lactonizing
I6G98_22805	COG2866	Carboxypeptidase
I6G98_22810	COG0702	epimerase
I6G98_22815	COG1073	alpha beta
I6G98_22820	COG1073	alpha beta
I6G98_22825	COG0583	DNA-binding transcription factor activity
I6G98_22845	COG0668	transmembrane transport
I6G98_22850	COG3182	Iron-regulated membrane protein
I6G98_22855	COG0589	response to stress
I6G98_22860	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
I6G98_22865	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
I6G98_22880	COG1473	amidohydrolase
I6G98_22885	COG1473	amidohydrolase
I6G98_22890	COG0583	DNA-binding transcription factor activity
I6G98_22895	COG2840	Smr protein MutS2
I6G98_22900	COG3706	GGDEF domain
I6G98_22910	COG0513	Belongs to the DEAD box helicase family
I6G98_22920	COG0582	viral genome integration into host DNA
I6G98_22970	COG4197	protein conserved in bacteria, prophage-related
I6G98_22980	COG3756	Protein conserved in bacteria
I6G98_22985	COG1484	DNA-dependent DNA replication
I6G98_22990	COG1846	Transcriptional regulator
I6G98_23060	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
I6G98_23065	COG1475	DNA binding
I6G98_23150	COG5301	cellulose 1,4-beta-cellobiosidase activity
I6G98_23160	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I6G98_23165	COG1108	ABC-type Mn2 Zn2 transport systems permease components
I6G98_23170	COG1121	(ABC) transporter
I6G98_23185	COG0589	response to stress
I6G98_23195	COG3385	transposase activity
I6G98_23210	COG1013	pyruvate-flavodoxin oxidoreductase activity
I6G98_23210	COG0674	pyruvate-flavodoxin oxidoreductase activity
I6G98_23210	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
I6G98_23210	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
I6G98_23215	COG3042	response to heat
I6G98_23220	COG3187	Heat shock protein
I6G98_23225	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
I6G98_23230	COG2911	Protein conserved in bacteria
I6G98_23240	COG3784	Protein of unknown function (DUF1318)
I6G98_23245	COG2207	Transcriptional regulator
I6G98_23250	COG1012	belongs to the aldehyde dehydrogenase family
I6G98_23255	COG3733	amine oxidase
I6G98_23260	COG1012	belongs to the aldehyde dehydrogenase family
I6G98_23260	COG2030	dehydratase
I6G98_23265	COG3396	Phenylacetate-CoA oxygenase
I6G98_23270	COG3460	Phenylacetate-CoA oxygenase
I6G98_23275	COG3396	Phenylacetate-CoA oxygenase
I6G98_23280	COG2151	metal-sulfur cluster biosynthetic enzyme
I6G98_23285	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6G98_23290	COG1024	Enoyl-CoA hydratase
I6G98_23295	COG1024	Enoyl-CoA hydratase
I6G98_23300	COG1250	3-hydroxyacyl-CoA dehydrogenase
I6G98_23305	COG2050	protein possibly involved in aromatic compounds catabolism
I6G98_23310	COG0183	Belongs to the thiolase family
I6G98_23315	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
I6G98_23320	COG3327	negative regulation of DNA-templated transcription, initiation
I6G98_23325	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
I6G98_23330	COG0667	Aldo Keto reductase
I6G98_23370	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
I6G98_23375	COG2162	N-hydroxyarylamine O-acetyltransferase activity
I6G98_23380	COG0384	phenazine biosynthesis protein PhzF
I6G98_23385	COG2181	nitrate reductase activity
I6G98_23390	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
I6G98_23395	COG1140	nitrate reductase beta subunit
I6G98_23400	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
I6G98_23405	COG2223	nitrite transmembrane transporter activity
I6G98_23420	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
I6G98_23425	COG0697	spore germination
I6G98_23435	COG0437	4 iron, 4 sulfur cluster binding
I6G98_23440	COG2864	formate dehydrogenase
I6G98_23445	COG3093	addiction module antidote protein HigA
I6G98_23450	COG1064	alcohol dehydrogenase
I6G98_23480	COG0601	transmembrane transport
I6G98_23485	COG0747	negative chemotaxis
I6G98_23490	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
I6G98_23495	COG2200	EAL domain
I6G98_23495	COG2199	diguanylate cyclase activity
I6G98_23495	COG2202	Pas domain
I6G98_23510	COG1649	PFAM Uncharacterised BCR, COG1649
I6G98_23515	COG0531	amino acid
I6G98_23520	COG0076	glutamate decarboxylase activity
I6G98_23540	COG0243	molybdopterin cofactor binding
I6G98_23550	COG3385	transposase activity
I6G98_23570	COG3539	Fimbrial protein
I6G98_23630	COG3781	membrane
I6G98_23640	COG2199	diguanylate cyclase activity
I6G98_23650	COG2066	Belongs to the glutaminase family
I6G98_23655	COG1012	belongs to the aldehyde dehydrogenase family
I6G98_23660	COG0583	DNA-binding transcription factor activity
I6G98_23680	COG1846	Transcriptional regulator
I6G98_23685	COG4977	sequence-specific DNA binding
I6G98_23695	COG2723	6-phospho-beta-galactosidase activity
I6G98_23705	COG0697	spore germination
I6G98_23730	COG3706	GGDEF domain
I6G98_23735	COG3111	PFAM Bacterial OB fold (BOF) protein
I6G98_23740	COG1546	Belongs to the CinA family
I6G98_23745	COG0339	signal peptide processing
I6G98_23750	COG4221	oxidoreductase activity
I6G98_23755	COG1802	Transcriptional regulator
I6G98_23765	COG0246	Mannitol dehydrogenase
I6G98_23770	COG0477	Major facilitator Superfamily
I6G98_23790	COG4948	Mandelate Racemase Muconate Lactonizing
I6G98_23805	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
I6G98_23825	COG0243	molybdopterin cofactor binding
I6G98_23830	COG0437	4 iron, 4 sulfur cluster binding
I6G98_23840	COG3381	protein complex oligomerization
I6G98_23850	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
I6G98_23855	COG1940	carbohydrate kinase activity
I6G98_23860	COG0583	DNA-binding transcription factor activity
I6G98_23865	COG2814	Major facilitator Superfamily
I6G98_23880	COG3591	Belongs to the peptidase S1B family
I6G98_23895	COG0628	permease
I6G98_23900	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
I6G98_23905	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
I6G98_23915	COG0531	amino acid
I6G98_23925	COG3136	membrane protein required for alginate biosynthesis
I6G98_23930	COG0745	RESPONSE REGULATOR receiver
I6G98_23935	COG2205	protein histidine kinase activity
I6G98_23945	COG0114	fumarate hydratase activity
I6G98_23950	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
I6G98_23950	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
I6G98_23955	COG1482	cell wall glycoprotein biosynthetic process
I6G98_23960	COG5339	Protein conserved in bacteria
I6G98_23975	COG3250	beta-galactosidase activity
I6G98_23985	COG1309	transcriptional regulator
I6G98_23990	COG1028	Short-chain dehydrogenase reductase Sdr
I6G98_23995	COG1609	Transcriptional regulator
I6G98_24000	COG1263	PTS System
I6G98_24000	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6G98_24005	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
I6G98_24015	COG0673	inositol 2-dehydrogenase activity
I6G98_24055	COG4659	FMN binding
I6G98_24065	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
I6G98_24070	COG3104	oligopeptide transport
I6G98_24075	COG0625	glutathione transferase activity
I6G98_24080	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
I6G98_24095	COG3895	Periplasmic Protein
I6G98_24105	COG3133	Outer membrane lipoprotein
I6G98_24120	COG1566	PFAM secretion protein HlyD family protein
I6G98_24130	COG2032	superoxide dismutase activity
I6G98_24135	COG4989	oxidoreductase activity
I6G98_24140	COG3313	Fe-S protein
I6G98_24145	COG1309	transcriptional regulator
I6G98_24150	COG1902	pentaerythritol trinitrate reductase activity
I6G98_24155	COG0346	lactoylglutathione lyase activity
I6G98_24165	COG1201	RNA secondary structure unwinding
I6G98_24170	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
I6G98_24180	COG0791	NLP P60 protein
I6G98_24185	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
I6G98_24190	COG2814	Major facilitator Superfamily
I6G98_24205	COG0583	DNA-binding transcription factor activity
I6G98_24210	COG2814	Major facilitator Superfamily
I6G98_24215	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
I6G98_24220	COG0307	riboflavin synthase, alpha
I6G98_24230	COG3468	outer membrane autotransporter barrel domain protein
I6G98_24250	COG4529	Protein conserved in bacteria
I6G98_24260	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
I6G98_24265	COG0437	4 iron, 4 sulfur cluster binding
I6G98_24275	COG2414	aldehyde ferredoxin oxidoreductase
I6G98_24280	COG0437	4 iron, 4 sulfur cluster binding
I6G98_24290	COG0469	pyruvate kinase activity
I6G98_24300	COG4238	major outer membrane lipoprotein
I6G98_24305	COG1376	ErfK ybiS ycfS ynhG family protein
I6G98_24320	COG0719	Fe-S assembly protein
I6G98_24330	COG0719	Fe-S assembly protein
I6G98_24335	COG0316	Belongs to the HesB IscA family
I6G98_24345	COG2050	protein possibly involved in aromatic compounds catabolism
I6G98_24350	COG0247	lactate metabolic process
I6G98_24350	COG0277	FAD linked oxidase domain protein
I6G98_24355	COG0628	permease
I6G98_24370	COG0738	Major facilitator superfamily
I6G98_24375	COG2271	Major facilitator Superfamily
I6G98_24390	COG4670	ketone body catabolic process
I6G98_24395	COG1960	acyl-CoA dehydrogenase activity
I6G98_24400	COG1917	Cupin 2, conserved barrel domain protein
I6G98_24400	COG2207	Transcriptional regulator
I6G98_24405	COG2086	electron transfer activity
I6G98_24425	COG0644	oxidoreductase
I6G98_24430	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
I6G98_24445	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
I6G98_24445	COG0574	Belongs to the PEP-utilizing enzyme family
I6G98_24455	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
I6G98_24460	COG4256	Hemin uptake protein
I6G98_24470	COG2200	EAL domain
I6G98_24475	COG0791	NLP P60 protein
I6G98_24485	COG0386	Belongs to the glutathione peroxidase family
I6G98_24505	COG4974	Belongs to the 'phage' integrase family
I6G98_24585	COG4695	Portal protein
I6G98_24665	COG5301	cellulose 1,4-beta-cellobiosidase activity
I6G98_24685	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
I6G98_24790	COG3137	Salt-induced outer membrane protein
I6G98_24795	COG1105	Belongs to the carbohydrate kinase PfkB family
I6G98_24805	COG3001	Fructosamine kinase
I6G98_24815	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
I6G98_24820	COG1988	membrane-bound metal-dependent
I6G98_24825	COG1823	symporter activity
I6G98_24840	COG0753	catalase activity
I6G98_24850	COG1486	melibiose metabolic process
I6G98_24855	COG1917	Cupin 2, conserved barrel domain protein
I6G98_24855	COG2169	Transcriptional regulator
I6G98_24860	COG1447	Phosphotransferase system cellobiose-specific component IIA
I6G98_24880	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
I6G98_24890	COG0322	excinuclease ABC activity
I6G98_24900	COG3678	ATP-independent chaperone mediated protein folding
I6G98_24935	COG0708	Exodeoxyribonuclease III
I6G98_24940	COG0398	Pfam SNARE associated Golgi protein
I6G98_24950	COG0398	Pfam SNARE associated Golgi protein
I6G98_24955	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
I6G98_24960	COG4134	Bacterial extracellular solute-binding protein
I6G98_24965	COG4135	transport system, permease component
I6G98_24970	COG4136	ATPase activity
I6G98_24975	COG2897	thiosulfate sulfurtransferase activity
I6G98_24980	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
I6G98_24985	COG0494	nUDIX hydrolase
I6G98_24995	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
I6G98_25005	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
I6G98_25015	COG0778	Nitroreductase
I6G98_25020	COG0616	signal peptide processing
I6G98_25025	COG0252	asparaginase activity
I6G98_25030	COG1335	isochorismatase
I6G98_25035	COG3139	Protein of unknown function (DUF1315)
I6G98_25045	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
I6G98_25050	COG0676	glucose-6-phosphate 1-epimerase activity
I6G98_25055	COG0656	L-ascorbic acid biosynthetic process
I6G98_25060	COG3713	MltA-interacting MipA family protein
I6G98_25065	COG2766	serine protein kinase
I6G98_25075	COG2199	diguanylate cyclase activity
I6G98_25080	COG2199	diguanylate cyclase activity
I6G98_25085	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
I6G98_25100	COG2207	Transcriptional regulator
I6G98_25105	COG2807	transmembrane transport
I6G98_25110	COG3189	MarR family transcriptional regulator
I6G98_25115	COG3042	response to heat
I6G98_25145	COG2261	transglycosylase associated protein
I6G98_25155	COG3615	Tellurite resistance protein tehB
I6G98_25165	COG0583	DNA-binding transcription factor activity
I6G98_25170	COG0473	3-isopropylmalate dehydrogenase activity
I6G98_25175	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
I6G98_25185	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
I6G98_25190	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
I6G98_25195	COG0318	PFAM AMP-dependent synthetase and ligase
I6G98_25200	COG3065	identical protein binding
I6G98_25205	COG1214	PFAM Peptidase M22, glycoprotease
I6G98_25210	COG1199	ATP-dependent helicase activity
I6G98_25215	COG0251	oxidation-reduction process
I6G98_25235	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
I6G98_25245	COG1760	l-serine dehydratase
I6G98_25255	COG1253	flavin adenine dinucleotide binding
I6G98_25260	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
I6G98_25260	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
I6G98_25265	COG3715	PTS system
I6G98_25270	COG3716	PTS system mannose fructose sorbose family IID component
I6G98_25285	COG2226	methyltransferase
I6G98_25320	COG1414	Transcriptional regulator
I6G98_25325	COG2814	Major facilitator Superfamily
I6G98_25335	COG0793	Belongs to the peptidase S41A family
I6G98_25345	COG1956	GAF domain-containing protein
I6G98_25350	COG2995	paraquat-inducible protein a
I6G98_25355	COG3008	intermembrane lipid transfer
I6G98_25405	COG5301	cellulose 1,4-beta-cellobiosidase activity
I6G98_25535	COG1783	phage Terminase large subunit
I6G98_25555	COG3772	lysozyme