locus-tag class description HLY11_00010 ENOG4105VZ1 Replication Protein HLY11_00020 ENOG4105ED4 portal protein HLY11_00115 ENOG4108US3 tail fiber assembly HLY11_00120 ENOG4105PTU response to oxidative stress HLY11_00130 ENOG4108C33 Resolvase HLY11_00170 ENOG4105ZTC transcriptional activator, Ogr delta HLY11_00175 ENOG4105CFP Peptidase U32 HLY11_00185 ENOG4105X54 addiction module antidote protein HLY11_00190 ENOG4105KWI UPF0339 protein HLY11_00195 ENOG4105E3W Two component transcriptional regulator (Winged helix family HLY11_00200 ENOG4105EB3 Histidine kinase HLY11_00220 ENOG4105ENT Efflux transporter rnd family, mfp subunit HLY11_00240 ENOG4108M24 von Willebrand factor, type A HLY11_00245 ENOG4105UM3 Inherit from NOG: serine threonine phosphoprotein phosphatase HLY11_00250 ENOG4105ZD5 Uncharacterized protein conserved in bacteria (DUF2314) HLY11_00255 ENOG4106E1W protein with protein kinase and helix-hairpin-helix DNA-binding HLY11_00260 ENOG4105R8A Heat shock protein HLY11_00265 ENOG4105D03 DNA-3-methyladenine glycosylase II HLY11_00270 ENOG4105BZU Histidine kinase HLY11_00275 ENOG4105DBI uridine monophosphokinase HLY11_00285 ENOG4108GAE asmA family HLY11_00290 ENOG4105EE5 Membrane protein terC HLY11_00300 ENOG4105DAY polysaccharide export protein HLY11_00305 ENOG4105KJF protein tyrosine phosphatase HLY11_00310 ENOG4105D75 Capsular exopolysaccharide family HLY11_00315 ENOG41090RK glycosyl transferase HLY11_00320 ENOG41068PY Colanic acid biosynthesis acetyltransferase wcaB HLY11_00325 ENOG4107RXY Glycosyl transferase HLY11_00330 ENOG4108NYJ Colanic acid HLY11_00335 ENOG4105ECJ Glycosyl Transferase HLY11_00340 ENOG4108Z90 colanic acid biosynthesis acetyltransferase wcaF HLY11_00345 ENOG4105C0K Gdp-mannose 4,6-dehydratase HLY11_00350 ENOG4105C30 Nad-dependent epimerase dehydratase HLY11_00355 ENOG4105FGF GDP-mannose mannosyl hydrolase HLY11_00360 ENOG4106CD9 glycosyl transferase group 1 HLY11_00365 ENOG4105CJT Mannose-1-phosphate guanylyltransferase HLY11_00370 ENOG4107QKV phosphomannomutase HLY11_00375 ENOG4105D3Q Sugar transferase HLY11_00380 ENOG4105PSV Polysaccharide Biosynthesis Protein HLY11_00385 ENOG4105C74 pyruvyl transferase HLY11_00390 ENOG4107T8Q Glycosyl transferase (Group 1 HLY11_00395 ENOG4105G1A colanic acid biosynthesis protein HLY11_00400 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase HLY11_00410 ENOG4108KMV Glycosyl transferase (Group 1 HLY11_00430 ENOG4105C5E polysaccharide biosynthesis protein HLY11_00450 ENOG4105CPK Glycosyl transferase (Group 1 HLY11_00455 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) HLY11_00460 ENOG4105C6Y Udp-glucose 6-dehydrogenase HLY11_00465 ENOG4108KPN Confers a modal distribution of chain length on the O- antigen component of lipopolysaccharide (LPS). Gives rise to a reduced number of short chain molecules and increases in numbers of longer molecules, with a modal value of 13 (in strain O111 M92) and of 17 (in strain K12) HLY11_00485 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) HLY11_00490 ENOG4105ECC imidazole-glycerol-phosphate dehydratase HLY11_00495 ENOG4105CIH Imidazole acetol-phosphate transaminase HLY11_00500 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) HLY11_00515 ENOG4107SRH Nad-dependent epimerase dehydratase HLY11_00520 ENOG4105EQ1 Transcriptional regulator HLY11_00530 ENOG4105CUB amino acid HLY11_00535 ENOG4105CJB Exodeoxyribonuclease I HLY11_00540 ENOG4105DZ1 carboxypeptidase HLY11_00550 ENOG4105DR8 Membrane HLY11_00560 ENOG4105KTW ethanolamine utilization protein HLY11_00565 ENOG4105M3W utilization protein HLY11_00575 ENOG4107QTR Required for nitrogen fixation. May be part of a membrane complex functioning as an intermediate in the electron transport to nitrogenase (By similarity) HLY11_00580 ENOG4105C0A alcohol dehydrogenase HLY11_00585 ENOG4108EKI Dehydrogenase HLY11_00595 ENOG4105WVM ethanolamine utilization protein EutN carboxysome structural protein Ccml HLY11_00605 ENOG4108VPX Involved in 1,2-propanediol (1,2-PD) degradation by catalyzing the conversion of propanoyl-CoA to propanoyl-phosphate (By similarity) HLY11_00610 ENOG4105KNY Microcompartments protein HLY11_00615 ENOG4105KNY Microcompartments protein HLY11_00625 ENOG41084PW diol glycerol dehydratase reactivating factor large subunit HLY11_00630 ENOG4108ZFT Dehydratase small subunit HLY11_00635 ENOG4105YCI dehydratase medium subunit HLY11_00640 ENOG4105DMB glycerol dehydratase HLY11_00645 ENOG4105EHR propanediol utilization protein pduB HLY11_00650 ENOG4105KNY Microcompartments protein HLY11_00655 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) HLY11_00660 ENOG4107XVH Transcriptional regulator HLY11_00665 ENOG4108P62 biosynthesis protein (CbiG) HLY11_00670 ENOG4108YZT Adenosylcobinamide kinase HLY11_00685 ENOG4108PXI ErfK YbiS YcfS YnhG HLY11_00695 ENOG4108X7Y Mannitol-specific cryptic phosphotransferase enzyme iia HLY11_00700 ENOG4105K18 The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane (By similarity) HLY11_00705 ENOG4105DT3 PTS system, galactitol-specific IIc component HLY11_00710 ENOG4108YZG isomerase HLY11_00715 ENOG4105E98 transcriptional regulator DeoR family HLY11_00725 ENOG4105K18 The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane (By similarity) HLY11_00730 ENOG4105DT3 PTS system, galactitol-specific IIc component HLY11_00735 ENOG4105DJV ribulose-phosphate 3-epimerase HLY11_00740 ENOG4105CHR reductase HLY11_00745 ENOG41080HJ 6-phospho 3-hexuloisomerase HLY11_00755 ENOG4106P55 Transcriptional regulator HLY11_00760 ENOG4107R11 Transcriptional regulator HLY11_00770 ENOG4105UQX Mate efflux family protein HLY11_00780 ENOG4105CDY transcriptional regulatory protein HLY11_00785 ENOG4105FYV Amp nucleosidase HLY11_00790 ENOG4105CSH Transporter HLY11_00800 ENOG4105TNG K13735 adhesin invasin HLY11_00810 ENOG4105EXZ Involved in the regulation of ptsG expression by binding and inactivating Mlc (By similarity) HLY11_00820 ENOG4108VKM cytochrome b561 HLY11_00825 ENOG4108MEK Metal-binding protein YodA HLY11_00830 ENOG4105DQ2 Is probably involved in the electron transfer between its heme and the molybdenum cofactor of the reductase catalytic subunit YedY (By similarity) HLY11_00840 ENOG4105VT2 5-hydroxyisourate hydrolase HLY11_00845 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HLY11_00850 ENOG4107ZY3 Histidine kinase HLY11_00860 ENOG4105FCK Membrane HLY11_00865 ENOG4105Y0K Inner membrane protein YedR HLY11_00870 ENOG4105EST Metal Dependent Phosphohydrolase HLY11_00875 ENOG4105DVF Cytosine-specific methyltransferase HLY11_00880 ENOG41090BB DNA mismatch endonuclease (vsr) HLY11_00885 ENOG4105FDR Membrane HLY11_00890 ENOG4105CKW Inner membrane protein yedI HLY11_00895 ENOG4105VNZ cytoplasmic protein HLY11_00900 ENOG4105BZU Histidine kinase HLY11_00910 ENOG4105YX3 cellular response to acidity HLY11_00920 ENOG4107TKS colanic acid capsular biosynthesis activation protein A HLY11_00925 ENOG4105D19 Role in flagellar biosynthesis (By similarity) HLY11_00935 ENOG4105CN7 Flagellar biosynthetic protein FliP HLY11_00940 ENOG4105K0P flagellar biosynthesis protein HLY11_00945 ENOG4105DD5 Flagellar motor switch protein HLY11_00950 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) HLY11_00955 ENOG4107ZI8 flagellar basal body-associated protein flil HLY11_00960 ENOG4105WF4 Flagellar hook-length control protein HLY11_00965 ENOG4105GSA Flagellar export protein flij HLY11_00970 ENOG4108JIR Flagellum-specific ATP synthase HLY11_00975 ENOG41090PJ Flagellar assembly protein HLY11_00980 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) HLY11_00985 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) HLY11_00990 ENOG4105VQ0 flagellar hook-basal body complex protein fliE HLY11_00995 ENOG4108RAV Conserved protein HLY11_01005 ENOG41066VF YeeE YedE family protein HLY11_01010 ENOG4108W9D (LipO)protein HLY11_01015 ENOG4105E5K Alpha-amylase HLY11_01020 ENOG4105YXP it directly binds FlhC, thus inhibiting the binding of the FlhC FlhD complex to class 2 promoters, resulting in decreased expression of class 2 flagellar operons. As a chaperone, effects FliD transition to the membrane by preventing its premature polymerization, and by directing it to the export apparatus (By similarity) HLY11_01025 ENOG4105MQ3 flagellar protein FliS HLY11_01030 ENOG4105DTS flagellar hook-associated HLY11_01035 ENOG4105I03 Flagellin HLY11_01040 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HLY11_01045 ENOG4108M9K flagella biosynthesis protein FliZ HLY11_01050 ENOG4105EAB amino acid AbC transporter HLY11_01055 ENOG4105K6H D-cysteine desulfhydrase HLY11_01060 ENOG4105E5Q amino acid AbC transporter HLY11_01065 ENOG4105CDA abc transporter atp-binding protein HLY11_01070 ENOG4105VJY transcriptional regulator HLY11_01075 ENOG4105XVG cytoplasmic protein HLY11_01085 ENOG4105WH1 Two component transcriptional regulator luxr family HLY11_01115 ENOG4106RHG Yeca family HLY11_01120 ENOG4105E0U tyrosine-specific transport protein HLY11_01125 ENOG4105VVZ metal-binding protein HLY11_01130 ENOG41090A1 ferritin HLY11_01135 ENOG4105P23 (LipO)protein HLY11_01145 ENOG4105N4N Protein of unknown function (DUF2766) HLY11_01150 ENOG4108UEC Ferritin-like protein HLY11_01155 ENOG4105DMK Periplasmic binding protein LacI transcriptional regulator HLY11_01160 ENOG4105C2J ABC transporter HLY11_01165 ENOG4105CNN ABC, transporter HLY11_01170 ENOG4108K4C ec 3.1.3.12 HLY11_01180 ENOG4108VA4 Universal stress protein HLY11_01190 ENOG4106CIA Functions in complex with FlhD as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region HLY11_01195 ENOG4107RD7 Flagellar Motor Protein, MotA HLY11_01200 ENOG4105ER2 Ompa motb domain protein HLY11_01205 ENOG4105CBS Chea signal transduction histidine kinase HLY11_01210 ENOG4108V3W Chemotaxis protein, CheW HLY11_01215 ENOG4105C8Q Methyl-accepting chemotaxis HLY11_01220 ENOG4105C8Q Methyl-accepting chemotaxis HLY11_01225 ENOG4105BZU Histidine kinase HLY11_01235 ENOG4108VYJ response regulator receiver protein HLY11_01240 ENOG4108KCC Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P) (By similarity) HLY11_01250 ENOG4105C4Q deoxyguanosinetriphosphate triphosphohydrolase-like protein HLY11_01255 ENOG4105D00 flagellar biosynthetic protein flhB HLY11_01260 ENOG4105D7B Flagellar biosynthesis protein flha HLY11_01265 ENOG4105W13 flagellar protein HLY11_01275 ENOG4105C75 arginyL-tRNA synthetase HLY11_01280 ENOG4106ZCM YecM protein HLY11_01290 ENOG4105CUW cytochrome C-TYPE protein HLY11_01295 ENOG4108J2R molybdopterin oxidoreductase HLY11_01305 ENOG4105DA6 Catalyzes the conversion of 5-methoxyuridine (mo5U) to uridine-5-oxyacetic acid (cmo5U) at position 34 in tRNA. May also participate in the methylation of uridine-5-oxyacetic acid (cmo5U) to uridine-5-oxyacetic acid methyl ester (mcmo5U) (By similarity) HLY11_01310 ENOG4105WJG Glutathione HLY11_01315 ENOG41081XQ Conserved Protein HLY11_01320 ENOG4105D3W isochorismatase HLY11_01330 ENOG4108TIT dATP pyrophosphohydrolase HLY11_01335 ENOG4105CDY transcriptional regulatory protein HLY11_01345 ENOG4107S01 Repressor protein MetJ HLY11_01365 ENOG4105FAV ABC, transporter HLY11_01375 ENOG4105NXV High-affinity zinc uptake system protein HLY11_01380 ENOG4105DR5 peptidase HLY11_01385 ENOG4105NWR lipid A biosynthesis (Kdo)2-(Lauroyl)-lipid IVA acyltransferase HLY11_01390 ENOG4105CA9 Pyruvate kinase HLY11_01395 ENOG4106KNT transcriptional regulator HLY11_01400 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase HLY11_01405 ENOG4105C01 Dihydroxy-acid dehydratase HLY11_01410 ENOG4108UHU Aldolase HLY11_01420 ENOG4105X2V dna damage-inducible protein HLY11_01430 ENOG4108Q2J Inner membrane protein YebE HLY11_01435 ENOG4105CUG Oligopeptidase b HLY11_01440 ENOG4105UMD exodeoxyribonuclease X HLY11_01445 ENOG4108YGA nitrilase cyanide hydratase and apolipoprotein n-acyltransferase HLY11_01450 ENOG4105MPK DNA polymerase III subunit theta HLY11_01455 ENOG4105FXM Copper resistance protein HLY11_01460 ENOG4108PNC copper resistance HLY11_01465 ENOG4105NKT exported protein HLY11_01470 ENOG4108R1E Serine threonine protein phosphatase 1 HLY11_01475 ENOG4105UVW uncharacterized protein yebW HLY11_01480 ENOG4105WT8 Protein of unknown function (DUF1480) HLY11_01490 ENOG4105DY2 Paraquat-inducible protein b HLY11_01495 ENOG4105H2K paraquat-inducible protein a HLY11_01500 ENOG4108ZGC gaf domain protein HLY11_01505 ENOG41073DY may be a structural element that influences the osmotic activation of ProP at a post-translational level (By similarity) HLY11_01510 ENOG4105CN1 protease HLY11_01520 ENOG4105C0R drug resistance transporter emrb qaca subfamily HLY11_01525 ENOG4105J4Q Transcriptional regulator HLY11_01530 ENOG4105TIK HLY11_01540 ENOG4105Q3Y exported protein HLY11_01555 ENOG4105DHI Methyltransferase HLY11_01570 ENOG4105F3R pts system mannose fructose sorbose family iid HLY11_01575 ENOG4105ETZ PTS System HLY11_01580 ENOG4105DAS pts system HLY11_01585 ENOG4105EE5 Membrane protein terC HLY11_01590 ENOG4107XTP (EAL) domain protein HLY11_01595 ENOG4105EJQ L-serine dehydratase HLY11_01605 ENOG4105CRQ synthase (Component I) HLY11_01615 ENOG4105V2F Uncharacterized protein yoac HLY11_01620 ENOG4105M4H endoribonuclease L-psp HLY11_01625 ENOG4105DVT helicase HLY11_01630 ENOG41072GX Peptidase M22 Glycoprotease HLY11_01635 ENOG4105Y4Z Outer Membrane Lipoprotein HLY11_01640 ENOG4105CEY Amp-dependent synthetase and ligase HLY11_01645 ENOG4105ZIE Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity) HLY11_01655 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) HLY11_01660 ENOG4105EJC lysr family transcriptional regulator HLY11_01670 ENOG4108YS1 cytoplasmic protein HLY11_01675 ENOG4105YP6 Domain of unknown function (DUF1869) HLY11_01680 ENOG4105Y3U Transglycosylase-associated protein HLY11_01690 ENOG4106G4W HLY11_01695 ENOG410620I Diguanylate cyclase HLY11_01700 ENOG4105UCG Domain of unknown function (DUF333) HLY11_01705 ENOG4105K78 MarR family Transcriptional regulator HLY11_01710 ENOG4105DJ2 Major Facilitator Superfamily HLY11_01715 ENOG4105R1U AraC Family Transcriptional Regulator HLY11_01730 ENOG4108KXH Ybak prolyl-tRNA synthetase associated HLY11_01735 ENOG4108KHP Diguanylate cyclase HLY11_01740 ENOG4106KTS Inner membrane protein yeaI HLY11_01750 ENOG4105CYN Serine protein kinase HLY11_01755 ENOG4105GNX MltA-interacting MipA family protein HLY11_01760 ENOG4105CV8 reductase HLY11_01765 ENOG4105DSB aldose 1-epimerase HLY11_01770 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase HLY11_01780 ENOG4105VUT cytoplasmic protein HLY11_01785 ENOG4108RWI nicotinamidase HLY11_01790 ENOG4105HDK L-asparaginase HLY11_01800 ENOG4105D07 Signal peptide peptidase, SppA HLY11_01805 ENOG41069NU Nitroreductase HLY11_01810 ENOG4105D4F Synthesizes selenophosphate from selenide and ATP (By similarity) HLY11_01815 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) HLY11_01820 ENOG41065FB inner membrane protein ynji HLY11_01825 ENOG4105D82 Glutamate dehydrogenase HLY11_01830 ENOG4105MTM Protein of unknown function (DUF1496) HLY11_01835 ENOG4105M6F mutator MutT protein HLY11_01840 ENOG4108T9J Cdp-alcohol phosphatidyltransferase HLY11_01845 ENOG4107RM6 sulfurtransferase HLY11_01850 ENOG4108VGW abc transporter atp-binding protein HLY11_01855 ENOG4105CXZ ABC transporter, permease HLY11_01860 ENOG4105VNH ABC transporter solute-binding protein HLY11_01865 ENOG4107ZN8 Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) HLY11_01870 ENOG4108N5C SNARE associated Golgi protein-related protein HLY11_01875 ENOG4108KCW iron-sulfur cluster binding HLY11_01880 ENOG4108RSN SNARE associated Golgi HLY11_01885 ENOG4105CGK Exodeoxyribonuclease III HLY11_01900 ENOG4105C26 Dehydrogenase HLY11_01905 ENOG4105EY2 Catalyzes the hydrolysis of N(2)-succinylarginine into N(2)-succinylornithine, ammonia and CO(2) (By similarity) HLY11_01915 ENOG4108SPG Periplasmic Protein HLY11_01925 ENOG4105DKD Incises the DNA at the 3' side of a lesion during nucleotide excision repair. Incises the DNA farther away from the lesion than UvrC. Not able to incise the 5' site of a lesion. When a lesion remains because UvrC is not able to induce the 3' incision, Cho incises the DNA. Then UvrC makes the 5' incision. The combined action of Cho and UvrC broadens the substrate range of nucleotide excision repair (By similarity) HLY11_01935 ENOG4105KKI DNA-binding transcriptional activator OsmE HLY11_01940 ENOG4105VZJ PTS System HLY11_01945 ENOG4105CK1 PTS System HLY11_01950 ENOG4105VCP PTS System HLY11_01955 ENOG4105EZV Transcriptional regulator HLY11_01960 ENOG4105F8D glycoside hydrolase family 4 HLY11_01970 ENOG4105CH6 catalase HLY11_01985 ENOG4108ETY sodium dicarboxylate symporter HLY11_01990 ENOG4107K5X Membrane-bound metal-dependent hydrolase HLY11_01995 ENOG4107UW8 HAD-superfamily hydrolase subfamily IA variant 3 HLY11_02000 ENOG4107PN8 YfeABCD locus regulator HLY11_02010 ENOG4105P10 Uncharacterized protein ydiZ HLY11_02015 ENOG4105DE4 1-phosphofructokinase HLY11_02020 ENOG4108NE3 Salt-induced outer membrane protein HLY11_02040 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) HLY11_02045 ENOG41082NX 50s ribosomal protein l35 HLY11_02080 ENOG4108V06 Glutathione peroxidase HLY11_02090 ENOG4108QBX (LipO)protein HLY11_02095 ENOG4108TC0 Diguanylate phosphodiesterase HLY11_02110 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) HLY11_02120 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) HLY11_02125 ENOG4105CEY Amp-dependent synthetase and ligase HLY11_02130 ENOG41090P5 ferredoxin-like protein HLY11_02135 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase HLY11_02140 ENOG4105C10 Electron transfer flavoprotein HLY11_02145 ENOG4105CV7 Electron transfer flavoprotein HLY11_02150 ENOG4105W4W Transcriptional regulator HLY11_02155 ENOG4105C1G acyl-Coa dehydrogenase HLY11_02160 ENOG4108IIG CoA transferase having broad substrate specificity for short-chain acyl-CoA thioesters with the activity decreasing when the length of the carboxylic acid chain exceeds four carbons (By similarity) HLY11_02175 ENOG4105EMV Major Facilitator HLY11_02180 ENOG4105EMV Major Facilitator HLY11_02185 ENOG4105SUA Ydil protein HLY11_02195 ENOG4105IPI Membrane HLY11_02200 ENOG4105CQB FAD linked oxidase domain protein HLY11_02205 ENOG4105KA0 thioesterase Superfamily protein HLY11_02210 ENOG410671Z uncharacterized protein ydiH HLY11_02215 ENOG4108Z4V iron-sulfur cluster assembly HLY11_02220 ENOG4105DIW FeS assembly protein SUFB HLY11_02225 ENOG4105C3K feS assembly ATPase SufC HLY11_02230 ENOG4105JRK feS assembly protein SufD HLY11_02245 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein HLY11_02250 ENOG4105KMX major outer membrane lipoprotein HLY11_02255 ENOG4105CA9 Pyruvate kinase HLY11_02260 ENOG4105RFR Protein of unknown function (DUF2767) HLY11_02265 ENOG4108PU5 4fe-4S ferredoxin, iron-sulfur binding domain protein HLY11_02270 ENOG4105WE2 aldehyde ferredoxin oxidoreductase HLY11_02275 ENOG4105JVW HLY11_02280 ENOG4108393 oxidoreductase Fe-S subunit HLY11_02285 ENOG4108NWD Cytochrome HLY11_02290 ENOG4108Y7C Conserved Protein HLY11_02295 ENOG4108KTU conserved protein with FAD NAD(P)-binding domain HLY11_02300 ENOG4105N0V mono-oxygenase ydhR HLY11_02325 ENOG4108R6K riboflavin synthase, subunit alpha HLY11_02330 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase HLY11_02335 ENOG4105CZQ inner membrane transport protein YdhC HLY11_02340 ENOG4105F52 Transcriptional regulator HLY11_02355 ENOG4105F27 Major Facilitator HLY11_02360 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) HLY11_02365 ENOG4105K4H Nlp p60 protein HLY11_02370 ENOG4105M2J Glutaredoxin HLY11_02375 ENOG4107QRT dEAD DEAH box helicase HLY11_02385 ENOG4108UYE Lactoylglutathione lyase HLY11_02390 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HLY11_02395 ENOG4108WUH Transcriptional regulator, TetR family HLY11_02400 ENOG4105XZD Fe-S protein HLY11_02405 ENOG4107RGM aldo keto reductase HLY11_02410 ENOG4108Z7T Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) HLY11_02415 ENOG4105DSW Fusaric acid resistance protein HLY11_02420 ENOG4105Y49 secretion protein, HlyD family HLY11_02435 ENOG4108XTF Outer Membrane Lipoprotein HLY11_02445 ENOG410642K Lysozyme inhibitor HLY11_02460 ENOG4107XGF functions in a salvage pathway. Uses pyridoxamine (By similarity) HLY11_02465 ENOG4108K3A Glutathione S-transferase HLY11_02470 ENOG4105DUX Transporter HLY11_02475 ENOG4105CSM endonuclease III HLY11_02485 ENOG4108UQQ Electron transport complex HLY11_02510 ENOG4105M9B inner membrane protein ydgK HLY11_02515 ENOG4105QZ5 OriC-binding nucleoid-associated protein HLY11_02520 ENOG4106C6R beta-lactam resistance protein HLY11_02525 ENOG4105D9R oxidoreductase HLY11_02535 ENOG4105C87 Aminotransferase class I and II HLY11_02540 ENOG4105CI1 PTS System HLY11_02545 ENOG4107P2S Transcriptional regulator HLY11_02550 ENOG4107ZQV short-chain dehydrogenase reductase HLY11_02555 ENOG4105XEA Tetr family transcriptional regulator HLY11_02560 ENOG4105CNT hydrolase family 2 HLY11_02565 ENOG4105CT4 transporter HLY11_02570 ENOG4108QNI outer membrane porin protein HLY11_02575 ENOG4106J39 exported protein HLY11_02580 ENOG4105EIP mannose-6-phosphate isomerase HLY11_02585 ENOG4107GFK fumarate HLY11_02590 ENOG4105C9Q fumarate hydratase class II HLY11_02600 ENOG4105JJR Histidine kinase HLY11_02605 ENOG4107EXC regulatoR HLY11_02610 ENOG4105RA2 Membrane HLY11_02620 ENOG4105D5Q Arginine ornithine antiporter HLY11_02625 ENOG4105C5D exported protein HLY11_02630 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) HLY11_02635 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) HLY11_02655 ENOG4105CVW peptidase s1 and s6 chymotrypsin hap HLY11_02670 ENOG4105D94 Major Facilitator Superfamily HLY11_02675 ENOG4106NZI LysR family Transcriptional regulator HLY11_02680 ENOG4105DAG ROK family HLY11_02685 ENOG4105EWW Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) HLY11_02695 ENOG4108NEM leader-binding protein dmsD HLY11_02700 ENOG4107KGK dmso reductase anchor subunit HLY11_02705 ENOG4105QAX Iron-sulfur HLY11_02710 ENOG4105C3J Cysteine desulfurase HLY11_02715 ENOG4107QY8 reductase HLY11_02720 ENOG4105KBG Protein of unknown function (DUF1161) HLY11_02725 ENOG4105D69 UPF0257 lipoprotein ynfC HLY11_02730 ENOG4108MK9 spermidine N(1)-acetyltransferase HLY11_02745 ENOG4105CXK mandelate racemase muconate lactonizing HLY11_02750 ENOG4105CPQ Dehydrogenase HLY11_02760 ENOG4105DEI Mannitol dehydrogenase HLY11_02765 ENOG41061EV selenium-binding protein YdfZ HLY11_02770 ENOG4107XBN GntR Family Transcriptional Regulator HLY11_02775 ENOG4105EMU Dehydrogenase HLY11_02780 ENOG4105DGW oligopeptidase A HLY11_02785 ENOG4108WTK competence damage-inducible protein HLY11_02790 ENOG4108YDI single-species biofilm formation on inanimate substrate HLY11_02795 ENOG4105FSR swimming returnes to normal when residues 206-207 are both mutated to Ala. Overexpression also leads to a reduction in flagellar abundance and a 20-fold increase in c-di- GMP levels in vivo. Required for aminoglycoside-mediated induction of biofilm formation, it also plays a lesser role in biofilm production in response to other classes of translation inhibitors. The c-di-GMP produced by this enzyme up-regulates poly-GlcNAc production as well as the biofilm synthesis protein PgaD, although c-di-GMP is probably not the main inducing principle. Cyclic-di- GMP is a second messenger which controls cell surface-associated traits in bacteria HLY11_02805 ENOG4105E5W Transporter HLY11_02810 ENOG4108594 Permease of the drug metabolite transporter HLY11_02815 ENOG4106DNR multiple antibiotic resistance protein HLY11_02820 ENOG4108XW0 May be a transcriptional activator of genes involved in the multiple antibiotic resistance (Mar) phenotype. It can also activate genes such as sodA, zwf and micF HLY11_02825 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes HLY11_02845 ENOG4105EGI Transcriptional regulator HLY11_02850 ENOG4105C26 Dehydrogenase HLY11_02855 ENOG4105CSV Glutaminase HLY11_02860 ENOG4105M0C cytoplasmic protein HLY11_02865 ENOG4105BZU Histidine kinase HLY11_02875 ENOG4105FFC UPF0187 protein HLY11_02885 ENOG4105D7V transposase HLY11_02895 ENOG4105K34 Involved in the degradation of phospho-AI-2, thereby terminating induction of the lsr operon and closing the AI-2 signaling cycle. Catalyzes the cleavage of phosphorylated 4,5- dihydroxy-2,3-pentanedione (P-DPD) to 2-phosphoglycolic acid (PG) and another three-carbon compound HLY11_02915 ENOG41071MT Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane HLY11_02920 ENOG4105C2J ABC transporter HLY11_02930 ENOG4107RYS Autoinducer-2 (AI-2) kinase HLY11_02940 ENOG41061P8 Persistence to inhibition of murein or DNA biosynthesis regulatory protein HLY11_02945 ENOG4105CAF HipA N-terminal domain protein HLY11_02975 ENOG4105ETE Transcriptional regulator (LacI family HLY11_02985 ENOG4107EFR Flavocytochrome c HLY11_03005 ENOG4108RQP Major type 1 subunit fimbrin HLY11_03015 ENOG4105CW0 outer membrane usher protein HLY11_03020 ENOG4108WDE Fimbrial protein HLY11_03025 ENOG4106318 fimbrial-like protein YdeR HLY11_03030 ENOG4106PIH fimbrial-like protein ydeQ HLY11_03035 ENOG4107QKC Oxidoreductase alpha (molybdopterin) subunit HLY11_03045 ENOG4108NKV transcriptional regulator HLY11_03050 ENOG4105ENH Sulfatase HLY11_03055 ENOG4105C4X radical SAM domain protein HLY11_03065 ENOG4105CQ0 ABC transporter HLY11_03070 ENOG4105PE1 Receptor HLY11_03075 ENOG4107RAN Peptidase, M16 HLY11_03080 ENOG4105CVK Glutamate decarboxylase HLY11_03085 ENOG4105E5D amino acid HLY11_03090 ENOG4105F32 YngK protein HLY11_03095 ENOG4105BZU Histidine kinase HLY11_03100 ENOG4105BZU Histidine kinase HLY11_03105 ENOG4108UQS dipeptidase HLY11_03110 ENOG4105DEF Extracellular solute-binding protein, family 5 HLY11_03115 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HLY11_03120 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HLY11_03125 ENOG4105C3U ABC transporter HLY11_03130 ENOG4107H6U ABC transporter HLY11_03135 ENOG4108Z9K Osmotically inducible protein HLY11_03140 ENOG4105TPS biofilm-dependent modulation protein HLY11_03145 ENOG4107AV5 Although this protein associates with the 30S subunit of the ribosome it is not considered to be a bona fide ribosomal protein HLY11_03155 ENOG4105DQ4 alcohol dehydrogenase HLY11_03160 ENOG41084S7 Plasmid maintenance system antidote protein HLY11_03165 ENOG4108MG3 formate dehydrogenase HLY11_03170 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein HLY11_03180 ENOG4105RPH Inner membrane protein YddG HLY11_03190 ENOG4108UI3 Leucine Rich repeat HLY11_03195 ENOG4108UI3 Leucine Rich repeat HLY11_03200 ENOG4107QND Nitrite extrusion protein HLY11_03205 ENOG4105CRU nitrate reductase, alpha subunit HLY11_03210 ENOG4108IUE nitrate reductase beta subunit HLY11_03215 ENOG4108NZN Respiratory nitrate reductase 2 delta chain HLY11_03220 ENOG4105D0D Nitrate reductase 2, gamma subunit HLY11_03225 ENOG4105JAB phenazine biosynthesis protein, phzf family HLY11_03230 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase HLY11_03235 ENOG4108MEJ flavin reductase domain protein HLY11_03270 ENOG4108N27 Glutathione S-transferase HLY11_03275 ENOG4105C85 amino acid HLY11_03280 ENOG4108NS2 receptor HLY11_03285 ENOG4105CHB tonB-dependent Receptor HLY11_03290 ENOG4108WYP Transcriptional regulator HLY11_03295 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein HLY11_03300 ENOG4108Z7F N-acetyltransferase HLY11_03305 ENOG4108T9Y Inner membrane protein ydcZ HLY11_03310 ENOG4105R71 cytoplasmic protein HLY11_03315 ENOG410654E Membrane HLY11_03330 ENOG4105NRK Binding-protein-dependent transport systems, inner membrane component HLY11_03335 ENOG4105D81 ABC transporter, permease HLY11_03340 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HLY11_03345 ENOG4107TYH extracellular solute-binding protein family 1 HLY11_03350 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HLY11_03355 ENOG4105PF0 Antitoxin component of a toxin-antitoxin (TA) module. Functions as an mRNA interferase antitoxin HLY11_03365 ENOG4105RR0 Protein of unknown function (DUF2554) HLY11_03370 ENOG4105CFP Peptidase U32 HLY11_03375 ENOG4108JCI Transcriptional regulator HLY11_03380 ENOG4105DKK Benzoate HLY11_03385 ENOG4108KKZ (LipO)protein HLY11_03390 ENOG41088CC tellurite resistance protein tehB HLY11_03395 ENOG4108NKP c4-dicarboxylate transporter malic acid transport protein HLY11_03400 ENOG4107WE3 acetyltransferase YdcK HLY11_03405 ENOG4108Z9I -acetyltransferase HLY11_03410 ENOG4105Z2P Protein of unknown function (DUF465) HLY11_03420 ENOG4105E32 cytoplasmic protein HLY11_03425 ENOG4105DDW LysR family Transcriptional regulator HLY11_03430 ENOG4105C8Q Methyl-accepting chemotaxis HLY11_03435 ENOG4107NK6 Hok/gef family HLY11_03440 ENOG4105UPP uncharacterized protein ydcA HLY11_03445 ENOG4105CPW cytochrome b561 HLY11_03450 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase HLY11_03455 ENOG4105C26 Dehydrogenase HLY11_03460 ENOG4107DB1 DUF218 domain HLY11_03465 ENOG4105CQ7 ATP-dependent helicase HLY11_03475 ENOG41077RS Phosphatase HLY11_03480 ENOG4105E8V Alpha Beta Hydrolase Fold protein HLY11_03485 ENOG4108HPI phosphatidate Cytidylyltransferase HLY11_03490 ENOG4108UMZ Cdp-alcohol phosphatidyltransferase HLY11_03500 ENOG4107S5I aldo keto reductase HLY11_03505 ENOG4107EF2 surface-exposed virulence protein HLY11_03510 ENOG4105WXT Conserved Protein HLY11_03515 ENOG410689M (LipO)protein HLY11_03520 ENOG4107H52 Dicarboxylate transport HLY11_03525 ENOG4105C5I Dehydrogenase HLY11_03530 ENOG41090X5 Heat shock protein hslJ HLY11_03535 ENOG4105IKK cytoplasmic protein HLY11_03540 ENOG4105D95 Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity) HLY11_03545 ENOG4105FCK Membrane HLY11_03550 ENOG4108RW8 Universal stress protein F HLY11_03560 ENOG4105C1J atp-dependent rna helicase HLY11_03570 ENOG4105BZU Histidine kinase HLY11_03575 ENOG4108DG9 Smr protein MutS2 HLY11_03580 ENOG4106KR7 LysR family Transcriptional regulator HLY11_03585 ENOG4105CH2 amidohydrolase HLY11_03590 ENOG4107RT5 aminobenzoyl-glutamate utilization protein B HLY11_03595 ENOG4105CFC Transporter HLY11_03600 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) HLY11_03605 ENOG4105DS0 Transcriptional regulator, Crp Fnr family HLY11_03610 ENOG4105Q9Y Universal stress protein HLY11_03615 ENOG4105S5I Membrane HLY11_03620 ENOG4105D64 Mechanosensitive ion channel HLY11_03625 ENOG4107QSI ABC, transporter HLY11_03630 ENOG4105KXI murein peptide amidase A HLY11_03635 ENOG4107S8C mandelate racemase muconate lactonizing HLY11_03640 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) HLY11_03650 ENOG4108JU8 Transcriptional regulator HLY11_03660 ENOG4105CM6 amino acid regulated cytosolic protein HLY11_03665 ENOG4105FKQ transcriptional regulator HLY11_03670 ENOG4107EFV Outer membrane protein G HLY11_03675 ENOG4108IJ9 (ABC) transporter HLY11_03680 ENOG4107URF beta-phospho-glucomutase HLY11_03685 ENOG4105C71 hydrolase family 65, central catalytic HLY11_03690 ENOG4105CK5 oxidoreductase HLY11_03695 ENOG4107TYA transient receptor potential locus HLY11_03700 ENOG4107RRD Dehydrogenase HLY11_03705 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component HLY11_03710 ENOG4105HS6 binding-protein-dependent transport systems inner membrane Component HLY11_03715 ENOG4105WEM extracellular solute-binding protein HLY11_03720 ENOG4107QW3 Sucrose phosphorylase HLY11_03725 ENOG4105K8Z Phage shock protein HLY11_03730 ENOG4105NNG Peripheral inner membrane phage-shock protein HLY11_03735 ENOG4105FM1 phage shock protein C HLY11_03740 ENOG4105YYT phage shock protein B HLY11_03745 ENOG41087YS Phage shock protein A HLY11_03750 ENOG4105E51 psp operon transcriptional activator HLY11_03755 ENOG4108JPW Aminotransferase HLY11_03760 ENOG4105CJP fad dependent oxidoreductase HLY11_03765 ENOG4105C26 Dehydrogenase HLY11_03770 ENOG4107VRI Transcriptional regulator HLY11_03775 ENOG4108Z86 Glutamine amidotransferase HLY11_03780 ENOG4105CFQ glutamine synthetase HLY11_03790 ENOG4105CUB amino acid HLY11_03795 ENOG4105N0E Protein of unknown function (DUF2543) HLY11_03800 ENOG4108HIY periplasmic HLY11_03805 ENOG4108I5W peptide transport system, permease protein HLY11_03810 ENOG4108EU3 peptide transport system, permease HLY11_03815 ENOG4108JQ3 Peptide ABC transporter ATP-binding protein HLY11_03820 ENOG4108JQ2 peptide transport system atp-binding protein HLY11_03825 ENOG4105WDY DNA (cytosine-5-)-methyltransferase HLY11_03830 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH HLY11_03835 ENOG4105Q4T oxidoreductase HLY11_03850 ENOG4105BZU Histidine kinase HLY11_03855 ENOG410643D UPF0509 protein HLY11_03860 ENOG4105N2W Transcriptional regulator HLY11_03870 ENOG4108ZJT translation initiation factor, Sui1 HLY11_03880 ENOG4105CFV Tetratricopeptide repeat protein HLY11_03885 ENOG4105Q4A inner membrane protein yciS HLY11_03890 ENOG4105EYK Phosphatidylglycerophosphatase B HLY11_03900 ENOG4107QM5 aconitate hydratase HLY11_03920 ENOG4107R11 Transcriptional regulator HLY11_03925 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) HLY11_03930 ENOG4105RKX Protein of unknown function (DUF2498) HLY11_03935 ENOG4105ERU peptidase HLY11_03940 ENOG4105UBK short-chain dehydrogenase reductase HLY11_03945 ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase HLY11_03950 ENOG4105FE9 pseudouridine synthase HLY11_03955 ENOG4107RTD sua5 ycio yrdc ywlc family protein HLY11_03960 ENOG4105DB7 PHP domain protein HLY11_03970 ENOG4105CRQ synthase (Component I) HLY11_03975 ENOG4108EFP Anthranilate synthase component II HLY11_03980 ENOG4105DK0 Indole-3-glycerol phosphate synthase HLY11_04000 ENOG4108Z9Z response to DNA damage stimulus HLY11_04005 ENOG4108N8X transition metal ion binding HLY11_04010 ENOG4105EIF outer membrane protein W HLY11_04030 ENOG4105NAU thioesterase Superfamily protein HLY11_04035 ENOG410822N TonB family HLY11_04040 ENOG4105K9H YciI-like protein HLY11_04045 ENOG4107SVH Potassium channel protein HLY11_04065 ENOG4105EYW Ion transport protein HLY11_04070 ENOG4108JQ7 (ABC) transporter HLY11_04075 ENOG4105C3U ABC transporter HLY11_04080 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HLY11_04085 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HLY11_04090 ENOG4108J59 Extracellular solute-binding protein, family 5 HLY11_04100 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein HLY11_04105 ENOG4105C0A alcohol dehydrogenase HLY11_04115 ENOG4107104 thymidine kinase HLY11_04120 ENOG4108SAU DNA-binding protein H-ns HLY11_04125 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase HLY11_04130 ENOG4105I93 response regulator HLY11_04135 ENOG4105D78 K07001 NTE family protein HLY11_04145 ENOG4105CIY formyltetrahydrofolate deformylase HLY11_04160 ENOG41076YT nitrate reductase, gamma subunit HLY11_04165 ENOG4105R3A Nitrate reductase HLY11_04170 ENOG4108IUE nitrate reductase beta subunit HLY11_04175 ENOG4105CRU nitrate reductase, alpha subunit HLY11_04180 ENOG4105DQQ Major facilitator superfamily MFS_1 HLY11_04185 ENOG4105BZU Histidine kinase HLY11_04190 ENOG4105WH1 Two component transcriptional regulator luxr family HLY11_04195 ENOG4105ID0 Putative invasin HLY11_04200 ENOG41090EX DsrE family HLY11_04205 ENOG4108NH8 Cation transport protein HLY11_04210 ENOG4105WS7 Cation transport regulator HLY11_04215 ENOG4105EWV Sodium calcium exchanger membrane region HLY11_04230 ENOG41063JG Transcriptional regulator HLY11_04235 ENOG4108YY7 Invasion gene expression up-regulator SirB HLY11_04240 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) HLY11_04250 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) HLY11_04265 ENOG4105C5T Phosphoribosyl pyrophosphate synthase HLY11_04270 ENOG4105CHH sulfate transporter HLY11_04275 ENOG4105MGX transcription activated by CRP (cyclic AMP receptor protein), a global transcription factor involved in regulation of metabolism in enteric bacteria HLY11_04285 ENOG4105C3G gtp-binding protein HLY11_04290 ENOG4105I1J Autotransporter HLY11_04300 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family HLY11_04305 ENOG4105CMT Dihydroxyacetone kinase HLY11_04310 ENOG4108UTZ Dihydroxyacetone kinase HLY11_04315 ENOG4105VDH Dihydroxyacetone kinase HLY11_04335 ENOG4108T7K Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Increasing levels of c-di-GMP lead to decreased motility (By similarity) HLY11_04345 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A HLY11_04365 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) HLY11_04375 ENOG4105ED1 spovr family HLY11_04390 ENOG410635M Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein (By similarity) HLY11_04395 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) HLY11_04400 ENOG4105KT5 UmuD protein HLY11_04405 ENOG4106PXS Toxin, which has some hemolytic activity towards mammalian cells. Acts by forming a pore-like structure upon contact with mammalian cells HLY11_04415 ENOG4105FBJ fumarylacetoacetate (faa) hydrolase HLY11_04425 ENOG41066UD Inhibits activity of g-type lysozyme, which confers increased lysozyme tolerance to the bacterium HLY11_04430 ENOG4105S66 prophage protein HLY11_04440 ENOG4107QMS site-determining protein HLY11_04470 ENOG410658X HLY11_04485 ENOG4105BZU Histidine kinase HLY11_04490 ENOG410738I uncharacterized protein ymgC HLY11_04500 ENOG41077SS Probably a connector protein for RcsB C regulation of biofilm formation, providing additional signal input into the two- component signaling pathway. May serve to stimulate biofilm maturation, probably via the Rcs phosphorelay. Mild overexpression at 16 degrees Celsius increases the production of colanic acid, an exopolysaccharide and matrix component, and reduces adhesive curli fimbriae expression. Both of these effects require RcsB HLY11_04505 ENOG4105WKE Probably a connector protein for RcsB C regulation of biofilm formation, providing additional signal input into the two- component signaling pathway. Partially antagonizes the activities of YmgA and AriR, proteins that, via the Rcs phosphorelay, promote the synthesis of colanic acid, an exopolysaccharide and matrix component HLY11_04510 ENOG4105BZU Histidine kinase HLY11_04515 ENOG4108XDN Transcriptional regulator HLY11_04520 ENOG41064WM Uncharacterized protein YcgX HLY11_04535 ENOG4108HMX isocitrate dehydrogenase (NADP) HLY11_04550 ENOG4108R99 pseudouridine synthase HLY11_04570 ENOG4107QTF adenylosuccinate lyase HLY11_04575 ENOG4105XJC Two component transcriptional regulator (Winged helix family HLY11_04580 ENOG4105IFJ Histidine kinase HLY11_04585 ENOG4105EZE Cupin 4 family protein HLY11_04595 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HLY11_04605 ENOG4105D38 putrescine abc transporter HLY11_04610 ENOG4107RUE extracellular solute-binding protein family 1 HLY11_04615 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) HLY11_04625 ENOG4105D60 lipoprotein releasing system transmembrane protein HLY11_04630 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) HLY11_04635 ENOG4105D60 lipoprotein releasing system transmembrane protein HLY11_04640 ENOG4105IQC Inner membrane protein YcfT HLY11_04645 ENOG4108JA2 transcriptioN-repair coupling factor HLY11_04650 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein HLY11_04655 ENOG4105RC8 Reduces the permeability of the outer membrane to copper. Seems to be involved in the regulation of biofilm formation. May decrease biofilm formation by repressing cell-cell interaction and cell surface interaction HLY11_04660 ENOG4108IND Tetr family transcriptional regulator HLY11_04665 ENOG4107MBR 17 kDa surface antigen HLY11_04670 ENOG4105CEP NADH dehydrogenase HLY11_04685 ENOG4108RUM thiamine kinase HLY11_04690 ENOG4108WEF Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b) (By similarity) HLY11_04695 ENOG41090DQ Lipoprotein HLY11_04700 ENOG4105K59 histidine triad (HIT) protein HLY11_04705 ENOG4105CNM Receptor HLY11_04710 ENOG4105CI1 PTS System HLY11_04715 ENOG4105F8V Hydrolase, tatD family HLY11_04720 ENOG4107QRG dna polymerase iii HLY11_04730 ENOG4105HHA aminodeoxychorismate lyase HLY11_04735 ENOG4105YAZ 4-amino-4-deoxychorismate lyase HLY11_04740 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) HLY11_04745 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) HLY11_04750 ENOG4105CHR reductase HLY11_04755 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase HLY11_04775 ENOG4105FCQ metal-binding, possibly nucleic acid-binding protein HLY11_04780 ENOG4108UHJ MAF-like protein HLY11_04785 ENOG4105EI2 Pseudouridine synthase HLY11_04790 ENOG4107QQB Ribonuclease E HLY11_04805 ENOG4105DTJ flagellar hook-associated protein HLY11_04810 ENOG4105E1Q flagellar hook-associated protein HLY11_04815 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj HLY11_04830 ENOG4105CGA flagellar basal-body rod protein FlgG HLY11_04835 ENOG4108KPB Flagellar basal-body rod protein FlgF HLY11_04840 ENOG4105BZE flagellar hook protein, FlgE HLY11_04845 ENOG4105W00 Flagellar hook capping protein HLY11_04850 ENOG4108ZC9 flagellar basal-body rod protein flgc HLY11_04855 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) HLY11_04860 ENOG4105CKS Flagella basal body P-ring formation protein flgA HLY11_04865 ENOG4105M9M anti-sigma28 factor FlgM HLY11_04870 ENOG4105QVD Flagella synthesis protein FlgN HLY11_04875 ENOG4105CJR Integral membrane protein (MviN HLY11_04880 ENOG4105EP9 oxidoreductase HLY11_04890 ENOG4105D9U N-acetyltransferase HLY11_04900 ENOG4105E9S glutaredoxin 2 HLY11_04905 ENOG4105F3T (LipO)protein HLY11_04910 ENOG4105EKE dihydroorotase HLY11_04915 ENOG4105MEA DNA damage-inducible protein i HLY11_04920 ENOG4105PVA Biofilm formation regulatory protein BssS HLY11_04930 ENOG4106974 biofilm formation HLY11_04935 ENOG4105DS1 cytochrome b561 HLY11_04940 ENOG4108YYC ycei family HLY11_04950 ENOG4105D1S lipid A biosynthesis HLY11_04960 ENOG4108W47 Acidic protein msyB HLY11_04965 ENOG4105NAC (LipO)protein HLY11_04970 ENOG4105C3A Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs) (By similarity) HLY11_04985 ENOG4107RZC phospholipase d HLY11_04990 ENOG4108UVJ appr-1-p processing domain protein HLY11_05005 ENOG4105G76 Curli are coiled surface structures that assemble preferentially at growth temperatures below 37 degrees Celsius. Curli can bind to fibronectin HLY11_05010 ENOG4108U0V Curli are coiled surface structures that assemble preferentially at growth temperatures below 37 degrees Celsius. Curli can bind to fibronectin. The minor subunit is the nucleation component of curlin monomers HLY11_05015 ENOG41086KC Transcriptional regulator HLY11_05020 ENOG4108XDW curli assembly protein CsgE HLY11_05025 ENOG4108WYR Curli production assembly transport component, CsgF HLY11_05030 ENOG4105P8Q Curli production assembly transport component CsgG HLY11_05035 ENOG4108UQ5 membrane protein YcdZ HLY11_05040 ENOG4107XHZ cytoplasmic chaperone TorD family protein HLY11_05050 ENOG4105JPG D-isomer specific 2-hydroxyacid dehydrogenase HLY11_05075 ENOG4105MAW Antitoxin component of a toxin-antitoxin (TA) module. Labile antitoxin that counteracts the effect of the CbtA (YeeV) toxin. It does not bind to the cognate toxin but instead binds to MreB and FtsZ (the toxin targets), enhancing their polymerization by forming higher-order bundles HLY11_05085 ENOG4108YGG dna repair protein HLY11_05090 ENOG4106549 Antirestriction protein HLY11_05100 ENOG4106H6R UPF0380 protein HLY11_05125 ENOG4108KZE transcriptional regulator HLY11_05130 ENOG4108MXD gtp-binding protein HLY11_05165 ENOG4105GQR Chaperone HLY11_05170 ENOG4105CW0 outer membrane usher protein HLY11_05215 ENOG4108P8R HLY11_05235 ENOG4108RS6 transposase HLY11_05240 ENOG4108T85 Membrane HLY11_05285 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) HLY11_05290 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) HLY11_05300 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) HLY11_05310 ENOG41081XD Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) HLY11_05315 ENOG4105D5K Hemolysin activator protein HLY11_05320 ENOG4105CKT filamentous hemagglutinin HLY11_05330 ENOG4105X0I Fimbrial HLY11_05335 ENOG4108AF8 Chaperone HLY11_05340 ENOG4105CW0 outer membrane usher protein HLY11_05350 ENOG4108MQF Chaperone HLY11_05355 ENOG4105CHR reductase HLY11_05360 ENOG4108TC1 Transcriptional regulator HLY11_05370 ENOG4105CXC rtn protein HLY11_05375 ENOG4105BZU Histidine kinase HLY11_05380 ENOG4108TUY outer membrane protein PgaA HLY11_05385 ENOG4107BJW polysaccharide deacetylase HLY11_05390 ENOG4105CND Glycosyl transferase, family 2 HLY11_05400 ENOG4105D5M phosphate starvation-inducible protein HLY11_05410 ENOG410650H (LipO)protein HLY11_05420 ENOG4105CK7 Sodium proline symporter HLY11_05425 ENOG4105C26 Dehydrogenase HLY11_05430 ENOG4108R86 Transcriptional regulator HLY11_05465 ENOG4105C2W permease HLY11_05470 ENOG4105XF5 Escherichia coli IMT2125 genomic chromosome, IMT2125 HLY11_05480 ENOG4105XH3 HLY11_05485 ENOG4105D6F Phosphatase HLY11_05510 ENOG4108EM1 reductase HLY11_05515 ENOG4105CUW cytochrome C-TYPE protein HLY11_05520 ENOG4106WF9 DNA-binding transcriptional regulator TorR HLY11_05525 ENOG4108SV3 Tmao reductase system periplasmic protein tort HLY11_05530 ENOG4105BZU Histidine kinase HLY11_05535 ENOG4105HEE Binding Domain protein HLY11_05540 ENOG4106H71 Overexpression increases levels of unsaturated fatty acids and suppresses both the temperature-sensitive fabA6 mutation and cold-sensitive secG null mutation HLY11_05555 ENOG4105VEQ Cold shock protein HLY11_05560 ENOG41060EU Cold shock-like protein HLY11_05565 ENOG4105D6F Phosphatase HLY11_05575 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii HLY11_05580 ENOG4105C4M (Ubiquinol oxidase) subunit I HLY11_05585 ENOG4105MVP hydrogenase-1 operon protein HyaF HLY11_05590 ENOG4108VXY Hydrogenase-1 operon protein HyaE HLY11_05595 ENOG4108USZ hydrogenase HLY11_05600 ENOG4105X7T Ni Fe-hydrogenase, b-type cytochrome subunit HLY11_05605 ENOG4105DPX Hydrogenase, large subunit HLY11_05610 ENOG4105E3S small subunit HLY11_05620 ENOG4108MN8 Membrane HLY11_05625 ENOG4108Z0T Part of a sulfur-relay system (By similarity) HLY11_05630 ENOG4105VSY K01512 acylphosphatase EC 3.6.1.7 HLY11_05645 ENOG4105K4P CoA-binding domain protein HLY11_05660 ENOG41088T4 Helicase IV HLY11_05665 ENOG410901E Membrane HLY11_05670 ENOG4105EM2 membrane HLY11_05675 ENOG4108RZ1 DNA transformation protein HLY11_05685 ENOG4105UYK outer membrane protein a HLY11_05695 ENOG4105DAN ATP-dependent protease HLY11_05705 ENOG4105WFT During stationary phase, converts 70S ribosomes to an inactive dimeric form (100S ribosomes) (By similarity) HLY11_05710 ENOG4108Q2G (LipO)protein HLY11_05715 ENOG4105DY2 Paraquat-inducible protein b HLY11_05720 ENOG4105F1S paraquat-inducible protein a HLY11_05725 ENOG4105C5H ABC transporter HLY11_05735 ENOG4105QVC MOSC domain-containing protein HLY11_05740 ENOG4108T7E Contributes to the efficiency of the cell division process by stabilizing the polymeric form of the cell division protein FtsZ. Acts by promoting interactions between FtsZ protofilaments and suppressing the GTPase activity of FtsZ (By similarity) HLY11_05750 ENOG4106PH7 chaperone HLY11_05755 ENOG4105MX3 Fimbrial HLY11_05760 ENOG4105Q7J Fimbrial HLY11_05765 ENOG4108MDY Fimbrial HLY11_05770 ENOG4105CW0 outer membrane usher protein HLY11_05775 ENOG4106JJN Part of the elfADCG-ycbUVF fimbrial operon, which promotes adhesion of bacteria to different abiotic surfaces. Could be required for the biogenesis of the ElfA fimbriae HLY11_05780 ENOG41071VI Part of the elfADCG-ycbUVF fimbrial operon, which promotes adhesion of bacteria to different abiotic surfaces. ElfA is the major fimbrial subunit produced by this operon HLY11_05785 ENOG4108UZX fmn reductase HLY11_05790 ENOG4105GVF (ABC) transporter HLY11_05800 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component HLY11_05805 ENOG4105E2Y ABC, transporter HLY11_05810 ENOG4105CD8 aminopeptidase N HLY11_05815 ENOG4107RH7 Nicotinate phosphoribosyltransferase HLY11_05825 ENOG4105FCK Membrane HLY11_05830 ENOG4105CGF Aromatic amino acid aminotransferase HLY11_05835 ENOG4105C5X domain protein HLY11_05840 ENOG4105EAQ (twin-arginine translocation) pathway signal HLY11_05845 ENOG4105DIT ErfK YbiS YcfS YnhG family protein HLY11_05855 ENOG4105DAH Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF (By similarity) HLY11_05865 ENOG4106371 Methyltransferase HLY11_05870 ENOG4107S90 membrAne HLY11_05875 ENOG4107VR7 transferase activity, transferring phosphorus-containing groups HLY11_05890 ENOG4105T0Z Conserved Protein HLY11_05900 ENOG4105BZ1 (ABC) transporter HLY11_05905 ENOG4108EQH DNA internalization-related competence protein ComEC Rec2 HLY11_05915 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) HLY11_05925 ENOG4108K0D peptidase, M48 HLY11_05940 ENOG4107VMU Membrane HLY11_05945 ENOG4105DDY UPF0142 protein ycaO HLY11_05950 ENOG4105TMB Formate nitrite transporter HLY11_05955 ENOG4105C6N Formate acetyltransferase HLY11_05960 ENOG4105F1A Pyruvate formate-lyase HLY11_05965 ENOG4108X0B nad(p)h dehydrogenase (quinone) HLY11_05970 ENOG410642W LysR family Transcriptional regulator HLY11_05975 ENOG4105E5D amino acid HLY11_05985 ENOG4105CHJ isochorismatase hydrolase HLY11_05990 ENOG4107KGK dmso reductase anchor subunit HLY11_05995 ENOG4105QAX Iron-sulfur HLY11_06000 ENOG4107QY8 reductase HLY11_06010 ENOG4105D1H recombination factor protein RarA HLY11_06020 ENOG4105CNU cell division protein FtsK HLY11_06030 ENOG4105C3M thioredoxin reductase HLY11_06035 ENOG4108JJ9 ABC, transporter HLY11_06040 ENOG4108JJ8 (ABC) transporter HLY11_06050 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) HLY11_06060 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit HLY11_06070 ENOG4105VEQ Cold shock protein HLY11_06075 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) HLY11_06080 ENOG4105DJY efflux transporter, rnd family, mfp subunit HLY11_06085 ENOG4108MJ5 VirK protein HLY11_06090 ENOG4105CPB ATP-dependent endonuclease of the OLD family HLY11_06095 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) HLY11_06100 ENOG4105DWU Membrane HLY11_06105 ENOG4105EJ7 Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity) HLY11_06110 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) HLY11_06115 ENOG4105C7K acetolactate synthase HLY11_06120 ENOG4105C5W Aldolase HLY11_06125 ENOG4105CGD Nad-dependent epimerase dehydratase HLY11_06130 ENOG4107VBM 3-beta hydroxysteroid dehydrogenase isomerase HLY11_06135 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase HLY11_06150 ENOG41064MM (LipO)protein HLY11_06155 ENOG4105E5Z arginine transporter ATP-binding subunit HLY11_06160 ENOG4106PMH Extracellular solute-binding protein family 3 HLY11_06165 ENOG4105GBT ABC transporter HLY11_06170 ENOG4105DMR ABC, transporter HLY11_06175 ENOG4106TNF Periplasmic binding protein HLY11_06200 ENOG4105RBQ inner membrane protein ybjO HLY11_06205 ENOG4105D38 putrescine abc transporter HLY11_06210 ENOG4105F38 ABC transporter, permease HLY11_06215 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HLY11_06220 ENOG4107RUE extracellular solute-binding protein family 1 HLY11_06225 ENOG4108RMJ sensory transduction regulator HLY11_06235 ENOG4108DBC nitroreductase HLY11_06240 ENOG4105X20 member of the soxRS regulon which mediates in part the increased levels of superoxide in response to oxidative stress HLY11_06245 ENOG41090BQ Glutaredoxin HLY11_06250 ENOG4105GWF inner membrane protein YbjM HLY11_06260 ENOG4105ZTC transcriptional activator, Ogr delta HLY11_06305 ENOG4105PTU response to oxidative stress HLY11_06310 ENOG4108US3 tail fiber assembly HLY11_06400 ENOG4105ED4 portal protein HLY11_06425 ENOG4105VZ1 Replication Protein HLY11_06430 ENOG4105DFE Dna adenine methylase HLY11_06435 ENOG4105KSC Transcriptional regulator, TraR DksA family HLY11_06460 ENOG4105MEH HLY11_06475 ENOG4108IYT Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HLY11_06480 ENOG4108RFG Tetr family transcriptional regulator HLY11_06485 ENOG4106UW1 Major Facilitator superfamily HLY11_06490 ENOG4108HCJ Hydrolase HLY11_06500 ENOG4107QF7 multi-drug HLY11_06505 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase HLY11_06510 ENOG4107FB0 transcriptional regulator DeoR family HLY11_06515 ENOG4105DZ1 carboxypeptidase HLY11_06520 ENOG4108TGY Glutathione S-transferase HLY11_06525 ENOG4105D8V Glucose sorbosone dehydrogenase HLY11_06530 ENOG4105UFT Represses biofilm formation in M9C glu and LB glu media but not in M9C and LB media. Seems to act as a global regulator of several genes involved in catabolite repression and stress response and regulation of the uptake and export of signaling pathways. Could be involved the regulation of indole as well as uptake and export of AI-2 through a cAMP-dependent pathway HLY11_06550 ENOG41064RH membrane protein YliF HLY11_06555 ENOG4105BZU Histidine kinase HLY11_06570 ENOG4105DEF Extracellular solute-binding protein, family 5 HLY11_06580 ENOG4105D44 asparaginase HLY11_06585 ENOG4105CVM Molybdenum cofactor synthesis domain protein HLY11_06590 ENOG4105D06 uba thif-type nad fad binding protein HLY11_06595 ENOG4107T9Z Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) HLY11_06600 ENOG4105F1A Pyruvate formate-lyase HLY11_06610 ENOG4108HCJ Hydrolase HLY11_06615 ENOG4105C5H ABC transporter HLY11_06620 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein HLY11_06625 ENOG4105F4P )-transporter HLY11_06630 ENOG4105KST dependent repressor HLY11_06640 ENOG4108I6E Sulfatase HLY11_06645 ENOG4108T1M outer membrane protein x HLY11_06655 ENOG4107AQZ Membrane HLY11_06665 ENOG4107R0W ABC transporter HLY11_06670 ENOG4105E5Q amino acid AbC transporter HLY11_06675 ENOG4105CDA abc transporter atp-binding protein HLY11_06680 ENOG4105D8X mechanosensitive ion channel HLY11_06690 ENOG4105ZY9 UPF0379 protein ybiM HLY11_06695 ENOG4108IU3 tonb-dependent siderophore receptor HLY11_06705 ENOG4105KSC Transcriptional regulator, TraR DksA family HLY11_06710 ENOG4105VR4 UPF0379 protein ybiJ HLY11_06715 ENOG4105DG4 malate L-lactate dehydrogenase HLY11_06720 ENOG4108MTB glycosyl transferase family HLY11_06725 ENOG4105DVT helicase HLY11_06740 ENOG4105C1J atp-dependent rna helicase HLY11_06745 ENOG4107MVR Transcriptional regulator HLY11_06755 ENOG4105CJ1 ABC, transporter HLY11_06760 ENOG4107QWP ABC-2 type transporter HLY11_06765 ENOG4107QWP ABC-2 type transporter HLY11_06770 ENOG4105I9U inner membrane protein ybhQ HLY11_06775 ENOG4105X23 Endonuclease Exonuclease phosphatase HLY11_06780 ENOG4105DZQ phospholipase D Transphosphatidylase HLY11_06785 ENOG4107UXM Membrane HLY11_06805 ENOG410733J conserved inner membrane protein HLY11_06810 ENOG410733J conserved inner membrane protein HLY11_06820 ENOG4105HFZ Membrane HLY11_06825 ENOG4108ZAF Molybdopterin HLY11_06830 ENOG4105M00 molybdopterin converting factor, subunit 1 HLY11_06840 ENOG4108RIR Molybdenum cofactor biosynthesis protein HLY11_06850 ENOG4105CHW UPF0052 protein HLY11_06860 ENOG4105E78 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) HLY11_06865 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) HLY11_06880 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) HLY11_06885 ENOG4108V1U phospholipid-binding protein HLY11_06890 ENOG4105NBR Pectinesterase HLY11_06895 ENOG4107QM5 aconitate hydratase HLY11_06900 ENOG4107QPK )-transporter HLY11_06905 ENOG4105C7F AcnD-accessory protein PrpF HLY11_06910 ENOG4105F04 LysR family Transcriptional regulator HLY11_06920 ENOG4108K4B hydrolase HLY11_06925 ENOG4105CGB Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system (By similarity) HLY11_06930 ENOG4105E0C molybdate abc transporter HLY11_06935 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein HLY11_06945 ENOG4105F4R Transcriptional regulator mode HLY11_06950 ENOG4105DKW ABC transporter HLY11_06955 ENOG4105CMR udp-glucose 4-epimerase HLY11_06960 ENOG4105F0Z galactose-1-phosphate uridylyltransferase HLY11_06970 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) HLY11_06980 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) HLY11_06985 ENOG4105JND homeobox protein HLY11_06990 ENOG4105PGM cation diffusion facilitator family transporter HLY11_06995 ENOG4106Z1T Nicotinamide Mononucleotide Transporter HLY11_07000 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) HLY11_07040 ENOG4105UFD tol-pal system protein YbgF HLY11_07045 ENOG4105KCK Peptidoglycan-associated lipoprotein HLY11_07055 ENOG4108Z82 Cell envelope integrity inner membrane protein TolA HLY11_07065 ENOG4105E02 MotA TolQ exbB proton channel HLY11_07070 ENOG4107YD3 Thioesterase HLY11_07075 ENOG4105KJB cyd operon protein YbgE HLY11_07085 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii HLY11_07090 ENOG4105C4M (Ubiquinol oxidase) subunit I HLY11_07105 ENOG4107WFU Glutamate mutase subunit sigma HLY11_07115 ENOG4105DJI Methylaspartate mutase, E subunit HLY11_07140 ENOG4107GFK fumarate HLY11_07145 ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase HLY11_07150 ENOG4105ETT transcriptional Regulator, LysR family HLY11_07160 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha HLY11_07170 ENOG4105C7S Dehydrogenase HLY11_07175 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 HLY11_07180 ENOG4105E33 succinate dehydrogenase HLY11_07185 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) HLY11_07190 ENOG4105N1I succinate dehydrogenase, hydrophobic membrane anchor protein HLY11_07195 ENOG4108UTY succinate dehydrogenase, cytochrome b556 subunit HLY11_07205 ENOG4105BZN citrate synthase HLY11_07210 ENOG4106UBK fimbrial-like adhesin protein HLY11_07215 ENOG4106PG1 outer membrane usher protein HLY11_07220 ENOG4108TTM chaperone HLY11_07225 ENOG4108MY7 Fimbrial HLY11_07230 ENOG4108KK1 membrane protein AbrB duplication HLY11_07245 ENOG4107R7A Allophanate hydrolase subunit 2 HLY11_07250 ENOG4105P4J Allophanate hydrolase, subunit 1 HLY11_07255 ENOG4107QNR UPF0135 protein HLY11_07260 ENOG4105DUX Transporter HLY11_07265 ENOG4105CVP deoxyribo-dipyrimidine photolyase HLY11_07270 ENOG4107SEY Conserved Protein HLY11_07275 ENOG4105XIQ Protein of unknown function (DUF2517) HLY11_07295 ENOG4108R80 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity) HLY11_07300 ENOG4105C08 Histidine kinase HLY11_07305 ENOG4105EEX Two component transcriptional regulator (Winged helix family HLY11_07320 ENOG4107QIX Phosphoglucomutase (EC 5.4.2.2 HLY11_07325 ENOG4107CDU Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated (By similarity) HLY11_07330 ENOG4105EV9 Alpha Beta Hydrolase HLY11_07335 ENOG4105NNH LexA regulated protein HLY11_07340 ENOG4105MHQ Low-potential electron donor to a number of redox enzymes (By similarity) HLY11_07350 ENOG41090R7 Ferric uptake HLY11_07355 ENOG4105GX6 (LipO)protein HLY11_07370 ENOG4105CI1 PTS System HLY11_07380 ENOG4105CE4 GlcNAc 6-P deacetylase HLY11_07385 ENOG4105E2R ROK family HLY11_07390 ENOG4105D4U had-superfamily hydrolase, subfamily iia HLY11_07395 ENOG4105CAQ asparagine synthetase HLY11_07440 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family HLY11_07450 ENOG4105C9A Phoh family HLY11_07460 ENOG4108JU5 Magnesium and cobalt efflux protein HLY11_07465 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) HLY11_07470 ENOG4107RP9 extracellular solute-binding protein, family 3 HLY11_07475 ENOG4105EAD ABC transporter HLY11_07480 ENOG4105DRP amino acid AbC transporter HLY11_07485 ENOG4105CDA abc transporter atp-binding protein HLY11_07495 ENOG4105F7F Chaperone HLY11_07500 ENOG4105QFC Hsc56 co-chaperone of HscC HLY11_07505 ENOG41069CF Protein of unknown function (DUF1266) HLY11_07510 ENOG4107JFD Sel1 repeat HLY11_07515 ENOG4105QFC Hsc56 co-chaperone of HscC HLY11_07520 ENOG41069CF Protein of unknown function (DUF1266) HLY11_07525 ENOG4105EUU Sel1 domain protein repeat-containing protein HLY11_07530 ENOG4107PAI alpha helical protein HLY11_07540 ENOG4108U2H Rare lipoprotein B HLY11_07545 ENOG4105DJF DNA polymerase III, delta' subunit HLY11_07555 ENOG4108TGR phosphatase HLY11_07560 ENOG4105KEM Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) HLY11_07570 ENOG4105CJN penicillin-binding protein HLY11_07575 ENOG4105CNI cell division protein FtsW HLY11_07580 ENOG4105K6T rare lipoprotein A HLY11_07585 ENOG4105DZ1 carboxypeptidase HLY11_07600 ENOG41064T2 transcriptional regulator, lysR family HLY11_07610 ENOG410607N Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatE shares overlapping functions with TatA (By similarity) HLY11_07630 ENOG41079UR PagP is required both for biosynthesis of hepta-acylated lipid A species containing palmitate and for resistance to cationic antimicrobial peptides (CAMPs). It catalyzes the transfer of a palmitate chain (16 0) from the sn-1 position of a glycerophospholipid to the free hydroxyl group of the (R)-3- hydroxymyristate chain at position 2 of lipid A (endotoxin) (By similarity) HLY11_07635 ENOG4105CEE C4-dicarboxylate transporter HLY11_07640 ENOG4106YYS transcriptional regulatory protein HLY11_07645 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism HLY11_07650 ENOG4105DUA (citrate (pro-3S)-lyase ligase HLY11_07660 ENOG4105CI0 Citrate lyase HLY11_07665 ENOG4105CHY citrate lyase, alpha HLY11_07680 ENOG4107QPK )-transporter HLY11_07685 ENOG4105KTS ribonuclease HLY11_07690 ENOG4105NXH GreA GreB family elongation factor HLY11_07695 ENOG4105E2A Dehydrogenase HLY11_07700 ENOG4108U51 Universal stress protein HLY11_07705 ENOG4108JU3 Alkyl hydroperoxide reductase HLY11_07710 ENOG4105D3R alkyl hydroperoxide reductase HLY11_07715 ENOG4108KHN disulfide isomerase, thiol-disulfide oxidase HLY11_07720 ENOG4105DQS Transcriptional regulator HLY11_07725 ENOG4105BZV Phosphoadenosine phosphosulfate reductase HLY11_07730 ENOG4105GTN ParB Domain Protein Nuclease HLY11_07735 ENOG4105CHM Aminotransferase HLY11_07740 ENOG4107SCQ Iron-containing alcohol dehydrogenase HLY11_07745 ENOG4105VCD cytoplasmic protein HLY11_07750 ENOG4105D22 carbon starvation protein HLY11_07755 ENOG4108TZA Required for optimal enterobactin synthesis. Acts as a proofreading enzyme that prevents EntB misacylation by hydrolyzing the thioester bound existing between EntB and wrongly charged molecules (By similarity) HLY11_07760 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase HLY11_07765 ENOG4105WQI isochorismatase HLY11_07770 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase HLY11_07775 ENOG4105E4F Isochorismate synthase HLY11_07780 ENOG4105PEC Iron-enterobactin transporter periplasmic binding protein HLY11_07790 ENOG4105DQ5 transport system permease protein HLY11_07795 ENOG4105TVJ transport system, permease HLY11_07800 ENOG4105E0A ABC, transporter HLY11_07805 ENOG4108QY5 Ferric enterobactin transport protein HLY11_07810 ENOG4105C0W non-ribosomal peptide synthetase HLY11_07815 ENOG41085A6 mbth domain-containing protein HLY11_07820 ENOG4105E93 esterase HLY11_07825 ENOG4107RNH Outer membrane receptor FepA HLY11_07830 ENOG4108TSE Transferase HLY11_07855 ENOG4105WQ6 Membrane HLY11_07860 ENOG4105MSB protein, conserved in bacteria HLY11_07865 ENOG4108RCM Nitroreductase HLY11_07870 ENOG4105CUY Mechanosensitive ion channel HLY11_07875 ENOG4105C85 amino acid HLY11_07880 ENOG4108IJF Heavy metal efflux pump, CzcA HLY11_07885 ENOG4105EP1 Efflux transporter rnd family, mfp subunit HLY11_07890 ENOG410624V efflux system protein HLY11_07895 ENOG4105ENJ RND efflux system, outer membrane lipoprotein HLY11_07900 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HLY11_07905 ENOG4105GR3 Histidine kinase HLY11_07910 ENOG410802X bacteriophage n4 adsorption protein b HLY11_07915 ENOG41090FC Bacteriophage N4 receptor, outer membrane subunit HLY11_07920 ENOG4105QUW HLY11_07935 ENOG4108Q9V regulatoR HLY11_07940 ENOG4108ZI2 Fimbrial protein HLY11_07945 ENOG4108M66 Involved in regulation of length and mediation of adhesion of SfmA fimbriae (but not necessary for the production of fimbriae). Seems to be mannose binding adhesin (By similarity) HLY11_07950 ENOG4105CW0 outer membrane usher protein HLY11_07955 ENOG4108AF8 Chaperone HLY11_07960 ENOG4108WDE Fimbrial protein HLY11_07970 ENOG4105WQ3 Rna-binding protein HLY11_07975 ENOG4105S2T inner membrane protein YbcI HLY11_07985 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) HLY11_07995 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) HLY11_08000 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit HLY11_08005 ENOG4105C5B carbamate kinase HLY11_08010 ENOG4105G5A Protein of unknown function (DUF2877) HLY11_08015 ENOG4107REC cytoplasmic protein HLY11_08020 ENOG4107R1Q Membrane protein FdrA HLY11_08025 ENOG4105DG4 malate L-lactate dehydrogenase HLY11_08030 ENOG4105CE7 Amidase, hydantoinase carbamoylase family HLY11_08035 ENOG4105S0E allantoin catabolism protein HLY11_08040 ENOG4105BZW Glycerate kinase HLY11_08045 ENOG4105DTE Xanthine uracil vitamin C permease HLY11_08055 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease HLY11_08060 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase HLY11_08065 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) HLY11_08070 ENOG41060W2 glyoxylate carboligase HLY11_08075 ENOG4108N16 Negative regulator of allantoin and glyoxylate utilization operons. Binds to the gcl promoter and to the allS- allA intergenic region HLY11_08085 ENOG4107653 Transcriptional regulator HLY11_08095 ENOG4105CV6 ABC transporter, permease HLY11_08100 ENOG4108I0Y (ABC) transporter HLY11_08105 ENOG4108UJV acyl-CoA thioesterase i HLY11_08110 ENOG4105E1F short-chain dehydrogenase reductase HLY11_08115 ENOG4107QR8 Thioredoxin HLY11_08120 ENOG4105C4B ABC transporter, permease HLY11_08125 ENOG41083J0 (ABC) transporter HLY11_08130 ENOG4107QX8 SPFH domain, Band 7 family protein HLY11_08135 ENOG4105G5H Membrane HLY11_08165 ENOG4107QZV Type I secretion membrane fusion protein HLY11_08185 ENOG4107RY6 amino acid HLY11_08190 ENOG4105CSV Glutaminase HLY11_08195 ENOG4105C59 p-type ATPase HLY11_08200 ENOG4105MBR gumn family HLY11_08205 ENOG4108Z66 YbaK ebsC protein HLY11_08210 ENOG4105CGH 5'-nucleotidase HLY11_08215 ENOG4105EU0 Major facilitator Superfamily HLY11_08220 ENOG4105CKD glutathione-regulated potassium-efflux system protein HLY11_08225 ENOG4107RE1 Inosine-guanosine kinase HLY11_08260 ENOG4107QMP dna polymerase iii subunits gamma and tau HLY11_08270 ENOG4105WD1 Membrane HLY11_08275 ENOG4108URS primosomal replication protein n'' HLY11_08280 ENOG4106428 Protein of unknown function (DUF2496) HLY11_08285 ENOG4105EGS Mechanosensitive ion channel HLY11_08290 ENOG4107XI7 Tetr family transcriptional regulator HLY11_08295 ENOG4105C1P efflux transporter, rnd family, mfp subunit HLY11_08300 ENOG4105BZS acriflavin resistance protein HLY11_08305 ENOG4108UKR Biofilm formation regulator YbaJ HLY11_08310 ENOG4105KF5 hemolysin expression-modulating protein HLY11_08315 ENOG4108UW5 maltose o-acetyltransferase HLY11_08320 ENOG4105GSJ Inner membrane protein ylaC HLY11_08325 ENOG41066DG (EAL) domain protein HLY11_08330 ENOG4105KCV RNA signal recognition particle 4.5S RNA HLY11_08340 ENOG41080UX Methyltransferase HLY11_08345 ENOG4108MNP Glycoprotein polysaccharide metabolism HLY11_08350 ENOG4105C29 acyl-CoA thioesterase HLY11_08355 ENOG4105BZU Histidine kinase HLY11_08360 ENOG4108YZA Nitrogen regulatory protein pii HLY11_08365 ENOG4105BZ1 (ABC) transporter HLY11_08370 ENOG4105BZ1 (ABC) transporter HLY11_08375 ENOG4108XM1 transcriptional regulator AsnC family HLY11_08385 ENOG4108NFA extracellular solute-binding protein HLY11_08395 ENOG4108TGP Thioesterase superfamily protein HLY11_08400 ENOG41083P1 competence protein ComEA helix-hairpin-helix repeat protein HLY11_08405 ENOG4105EIN peptidylprolyl cis-trans isomerase HLY11_08410 ENOG4105K70 DNA-binding protein HLY11_08415 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) HLY11_08435 ENOG4105M85 Bola protein HLY11_08440 ENOG4105IEY (LipO)protein HLY11_08445 ENOG4105EYM Major Facilitator superfamily HLY11_08450 ENOG4105E2S oxidase) subunit II HLY11_08455 ENOG4105BZ9 Cytochrome C oxidase, subunit I HLY11_08460 ENOG4105CCU oxidase (Subunit III) HLY11_08465 ENOG41090KH cytochrome o ubiquinol oxidase (subunit iv) HLY11_08490 ENOG4107RDB Major Facilitator HLY11_08500 ENOG4108JZF Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) HLY11_08505 ENOG4107S0N DJ-1 family HLY11_08510 ENOG4105D8I Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity) HLY11_08520 ENOG4105CTB Polyprenyl synthetase HLY11_08530 ENOG4105CPC Aldo Keto reductase HLY11_08540 ENOG4108ZAI phosphatidylglycerophosphatase a HLY11_08545 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) HLY11_08555 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) HLY11_08560 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) HLY11_08570 ENOG4108KIC (LipO)protein HLY11_08575 ENOG4105DRB nucleoside-specific channel-forming protein HLY11_08580 ENOG4105N1F Hnh endonuclease HLY11_08590 ENOG4105X54 addiction module antidote protein HLY11_08595 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) HLY11_08600 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) HLY11_08605 ENOG4105VIE preprotein translocase, subunit YajC HLY11_08630 ENOG4107R28 alpha amylase, catalytic region HLY11_08635 ENOG4105C85 amino acid HLY11_08640 ENOG4105CWM branched-chain amino acid transport system II carrier protein HLY11_08645 ENOG4105BZU Histidine kinase HLY11_08650 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HLY11_08655 ENOG4107RH8 nuclease SbcCD subunit D HLY11_08660 ENOG4105EYH Exonuclease HLY11_08665 ENOG4105F27 Major Facilitator HLY11_08670 ENOG4105DKQ ROK family HLY11_08695 ENOG4105HBA AroM protein HLY11_08700 ENOG4105SS3 HLY11_08715 ENOG4105II7 pyrroline-5-carboxylate reductase HLY11_08720 ENOG4105BZU Histidine kinase HLY11_08725 ENOG4105VIF phosphate starvation-inducible protein HLY11_08730 ENOG4105G6Z alkaline phosphatase HLY11_08745 ENOG4105CPF Cell wall formation (By similarity) HLY11_08750 ENOG4105UNH Membrane HLY11_08755 ENOG4105FR5 inner membrane protein YaiY HLY11_08760 ENOG4107QS8 (LipO)protein HLY11_08765 ENOG4108DQG in Escherichia coli SbmA is involved in uptake of microcin J25 HLY11_08770 ENOG4107R6D beta-lactam binding protein AmpH HLY11_08775 ENOG4108PNB DNA-binding transcriptional regulator HLY11_08785 ENOG4105D52 delta-aminolevulinic acid dehydratase HLY11_08790 ENOG4105E2B Taurine dioxygenase HLY11_08795 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component HLY11_08800 ENOG4108IY8 ABC, transporter HLY11_08805 ENOG4106FTQ Taurine ABC transporter, periplasmic HLY11_08810 ENOG4108KX4 response regulator HLY11_08815 ENOG4105BZU Histidine kinase HLY11_08820 ENOG4105CXY transporter HLY11_08825 ENOG4105C4Y ABC transporter HLY11_08830 ENOG4107RCV ABC transporter, permease HLY11_08835 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HLY11_08850 ENOG4105C4W S-formylglutathione hydrolase HLY11_08855 ENOG4105IUQ nucleoprotein polynucleotide-associated enzyme HLY11_08860 ENOG4108SC4 )-transporter HLY11_08865 ENOG4105DF3 Catalyzes the retro-aldol cleavage of 4-hydroxy-2- oxopentanoate to pyruvate and acetaldehyde. Is involved in the meta-cleavage pathway for the degradation of aromatic compounds (By similarity) HLY11_08880 ENOG4106HB6 Alpha beta hydrolase HLY11_08895 ENOG4108K2P TRANSCRIPTIONal HLY11_08900 ENOG4105IGJ Zn-dependent Hydrolase of the beta-lactamase fold protein HLY11_08915 ENOG4108IIG CoA transferase having broad substrate specificity for short-chain acyl-CoA thioesters with the activity decreasing when the length of the carboxylic acid chain exceeds four carbons (By similarity) HLY11_08920 ENOG4105CHR reductase HLY11_08925 ENOG4105CHU acetyl-coa acetyltransferase HLY11_08945 ENOG4107VHA regulatoR HLY11_08950 ENOG4105DJ2 Major Facilitator Superfamily HLY11_08960 ENOG4107B2H carbonic anhydrase HLY11_08965 ENOG4105DND Transcriptional regulator HLY11_08970 ENOG4105DZC cytosine deaminase HLY11_08975 ENOG4105DQW permease for cytosine purines, uracil, thiamine, allantoin HLY11_08980 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) HLY11_08985 ENOG4105DXD 2-methylcitrate dehydratase HLY11_08990 ENOG4105BZN citrate synthase HLY11_08995 ENOG4105CR4 methylisocitrate lyase HLY11_09000 ENOG4108JU7 Transcriptional regulator HLY11_09005 ENOG4105TDT uncharacterized protein yahO HLY11_09010 ENOG4105E82 cytochrome subunit of dehydrogenase HLY11_09025 ENOG4105DQ4 alcohol dehydrogenase HLY11_09035 ENOG4105DZC cytosine deaminase HLY11_09040 ENOG4105C5B carbamate kinase HLY11_09045 ENOG4107REC cytoplasmic protein HLY11_09050 ENOG4107R1Q Membrane protein FdrA HLY11_09055 ENOG4105N16 Protein of unknown function (DUF2877) HLY11_09060 ENOG4107SNB ankyrin repeat protein YahD HLY11_09065 ENOG4105SZ2 membrAne HLY11_09070 ENOG4108NUU Transcriptional regulator HLY11_09075 ENOG4105BZU Histidine kinase HLY11_09085 ENOG4105C94 Transporter HLY11_09100 ENOG4105CZ6 Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine (By similarity) HLY11_09140 ENOG4105EMU Dehydrogenase HLY11_09155 ENOG4108Z9Z response to DNA damage stimulus HLY11_09160 ENOG4108N8X transition metal ion binding HLY11_09165 ENOG4105WEF catalase HLY11_09170 ENOG4105UZW Tail fiber assembly protein HLY11_09195 ENOG4105FCK Membrane HLY11_09205 ENOG4105V1F Fermentation respiration switch protein HLY11_09215 ENOG4105CIN aminoacyl-histidine dipeptidase HLY11_09220 ENOG4108S2Y peptide Chain Release factor HLY11_09230 ENOG4108HYG acetyltransferase HLY11_09255 ENOG4108YS0 lipoprotein YafL HLY11_09265 ENOG4105VXN addiction module toxin, RelE StbE family HLY11_09270 ENOG4105F7V ErfK ybiS ycfS ynhG family protein HLY11_09275 ENOG4105E7A Glutamine amidotransferase HLY11_09285 ENOG4107QPN acyl-Coa dehydrogenase HLY11_09290 ENOG4108WN0 inhibitor of vertebrate lysozyme HLY11_09295 ENOG4105CZ7 nitrilase cyanide hydratase and apolipoprotein n-acyltransferase HLY11_09310 ENOG4105CNA YD repeat protein HLY11_09340 ENOG41090AA HLY11_09365 ENOG4105CS6 Rhs element vgr protein HLY11_09425 ENOG41090EK ompa motb domain protein HLY11_09475 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit HLY11_09515 ENOG4107RZZ dna polymerase iii epsilon subunit HLY11_09525 ENOG4105D1A Methyltransferase HLY11_09535 ENOG4105E9H Lytic Murein transglycosylase HLY11_09540 ENOG4105F2W methyltransferase HLY11_09550 ENOG4105HEI LysR family (Transcriptional regulator HLY11_09555 ENOG4105CV8 reductase HLY11_09590 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase HLY11_09595 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) HLY11_09600 ENOG4108UMI ABC transporter, permease HLY11_09605 ENOG4105D01 (LipO)protein HLY11_09610 ENOG4108R8X outer membrane lipoprotein HLY11_09615 ENOG4108R96 Methyltransferase, YaeB family HLY11_09625 ENOG4108UY0 (LipO)protein HLY11_09630 ENOG4107EII Lipoprotein involved with copper homeostasis and adhesion HLY11_09635 ENOG4108YZN class I peptide chain release factor HLY11_09640 ENOG4108VWS Yaeq family HLY11_09650 ENOG4105M1T rho-binding antiterminator HLY11_09655 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) HLY11_09660 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase HLY11_09665 ENOG4105CXN decarboxylase HLY11_09670 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) HLY11_09675 ENOG4105C0B DNA polymerase III (alpha subunit) HLY11_09700 ENOG4105D7M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) HLY11_09705 ENOG4108RFI Molecular chaperone that interacts specifically with outer membrane proteins, thus maintaining the solubility of early folding intermediates during passage through the periplasm (By similarity) HLY11_09715 ENOG4105DZP Membrane-associated zinc metalloprotease HLY11_09720 ENOG4105KNE Phosphatidate cytidylyltransferase HLY11_09725 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) HLY11_09730 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) HLY11_09755 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) HLY11_09775 ENOG4108IXP Carbohydrate diacid transcriptional activator CdaR HLY11_09780 ENOG4105C0H protease HLY11_09795 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) HLY11_09800 ENOG4105EN6 Membrane HLY11_09825 ENOG4105S6R Iron-hydroxamate transporter permease subunit HLY11_09830 ENOG4105J76 Periplasmic binding protein HLY11_09835 ENOG4105E0A ABC, transporter HLY11_09840 ENOG4105E0K tonB-dependent siderophore receptor HLY11_09845 ENOG4105BZ4 penicillin-binding protein HLY11_09850 ENOG4105CQ7 ATP-dependent helicase HLY11_09855 ENOG4107XID 2'-5' rna ligase HLY11_09870 ENOG4106F3G Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity) HLY11_09875 ENOG4105DJ0 Poly(A) Polymerase HLY11_09880 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase HLY11_09890 ENOG4108VEV chaperone HLY11_09895 ENOG4105CW0 outer membrane usher protein HLY11_09900 ENOG4108XEY fimbrial-like adhesin protein HLY11_09920 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) HLY11_09930 ENOG4108A32 Transposase HLY11_09940 ENOG4107BJW polysaccharide deacetylase HLY11_09945 ENOG4108YTN IIa component HLY11_09950 ENOG4105E3A (ABC) transporter HLY11_09955 ENOG4105DA5 (ABC) transporter HLY11_09960 ENOG41077A9 carbonic anhydrase HLY11_09965 ENOG4108UGV hypoxanthine phosphoribosyltransferase HLY11_09970 ENOG4105DZG Dehydrogenase HLY11_09975 ENOG4105E3B Multicopper oxidase HLY11_09980 ENOG4108ZRK uncharacterized protein yacC HLY11_10000 ENOG4107QIJ Aconitate hydratase 2 HLY11_10005 ENOG4108NST exported protein HLY11_10010 ENOG4107QN2 dihydrolipoyl dehydrogenase HLY11_10015 ENOG4107QSN dihydrolipoamide acetyltransferase HLY11_10020 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) HLY11_10025 ENOG41073TP transcriptional regulator HLY11_10030 ENOG4105C85 amino acid HLY11_10035 ENOG4106A72 regulatory protein AmpE HLY11_10040 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase HLY11_10045 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase HLY11_10050 ENOG4108ZUW Major pilin subunit HLY11_10055 ENOG4107QHF type ii secretion system protein e HLY11_10060 ENOG4105D7Q type ii secretion system HLY11_10070 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) HLY11_10085 ENOG4105M6F mutator MutT protein HLY11_10105 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) HLY11_10110 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) HLY11_10115 ENOG4105K7E Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity) HLY11_10120 ENOG4105CPF Cell wall formation (By similarity) HLY11_10135 ENOG4105CNI cell division protein FtsW HLY11_10140 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) HLY11_10150 ENOG4108EQQ Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity) HLY11_10155 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) HLY11_10160 ENOG4105CJN penicillin-binding protein HLY11_10165 ENOG41063Y6 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) HLY11_10180 ENOG4107B7Y DNA-binding transcriptional regulator FruR HLY11_10190 ENOG4108ZP8 Acetolactate synthase small subunit HLY11_10195 ENOG4105C7K acetolactate synthase HLY11_10200 ENOG41064T2 transcriptional regulator, lysR family HLY11_10230 ENOG4105S8Q sugar efflux transporter HLY11_10240 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) HLY11_10250 ENOG4105DP9 ABC transporter HLY11_10255 ENOG4106SMU thiamine transporter membrane protein HLY11_10270 ENOG4108KF1 Membrane HLY11_10275 ENOG41063TF transcriptional regulator (AraC HLY11_10280 ENOG4105EF1 ribulokinase HLY11_10290 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase HLY11_10295 ENOG4105CQ2 DNA polymerase HLY11_10300 ENOG4105BZK Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair (By similarity) HLY11_10305 ENOG4105D3G Pseudouridine synthase HLY11_10320 ENOG41066UG Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host (By similarity) HLY11_10330 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) HLY11_10370 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) HLY11_10385 ENOG4105M5B (LipO)protein HLY11_10390 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain HLY11_10395 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain HLY11_10405 ENOG4105DU0 nucleoside hydrolase HLY11_10415 ENOG41090X3 Peptidyl-prolyl cis-trans isomerase HLY11_10425 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) HLY11_10430 ENOG4105DTN riboflavin biosynthesis protein ribF HLY11_10435 ENOG410647N response to DNA damage stimulus HLY11_10455 ENOG4108MQF Chaperone HLY11_10460 ENOG4105CW0 outer membrane usher protein HLY11_10470 ENOG41063Z6 transcriptional regulator, lysR family HLY11_10485 ENOG41061MV Arylsulfatase HLY11_10495 ENOG4105WI6 cell killing protein encoded within cryptic prophage HLY11_10515 ENOG4108QUJ UPF0174 protein YaaW HLY11_10520 ENOG4106HK8 GPR1 FUN34 yaaH family protein HLY11_10525 ENOG4108RIR Molybdenum cofactor biosynthesis protein HLY11_10530 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) HLY11_10535 ENOG4105BZG amino acid carrier protein HLY11_10545 ENOG41062C6 Protein of unknown function (DUF2502) HLY11_10550 ENOG4105D98 threonine synthase HLY11_10560 ENOG4105CFH Aspartokinase HLY11_10570 ENOG4106FVC RNA methyltransferase HLY11_10575 ENOG410759A HLY11_10580 ENOG41065U4 response regulator HLY11_10585 ENOG4105CT7 inner membrane cred family protein HLY11_10590 ENOG4105EB3 Histidine kinase HLY11_10595 ENOG4105E3W Two component transcriptional regulator (Winged helix family HLY11_10600 ENOG4108RH0 Crea protein HLY11_10605 ENOG4105UEI Transcriptional Regulator AraC Family HLY11_10615 ENOG4108K16 Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) HLY11_10625 ENOG4107SC1 transglycosylase HLY11_10630 ENOG4105C5H ABC transporter HLY11_10640 ENOG4107VZS Nicotinamide-nucleotide adenylyltransferase HLY11_10645 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) HLY11_10650 ENOG4105EAC phosphoserine phosphatase HLY11_10655 ENOG41062Z9 Membrane HLY11_10670 ENOG4105D3A purine nucleoside phosphorylase DeoD-type HLY11_10690 ENOG4105G0K glycine radical enzyme YjjI family HLY11_10695 ENOG41076CZ activating enzyme HLY11_10700 ENOG4105EYA deoxyribonuclease HLY11_10705 ENOG4108NRW Phospholipase, patatin family HLY11_10715 ENOG4105K3G Periplasmic Protein HLY11_10725 ENOG4105PAD Hydrolase HLY11_10730 ENOG4105KEG ribosomal-protein-alanine acetyltransferase HLY11_10735 ENOG4108WPU DNA polymerase III subunit psi HLY11_10740 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) HLY11_10750 ENOG4105YBH Protein of unknown function (DUF1435) HLY11_10755 ENOG4108819 ferric iron reductase HLY11_10760 ENOG4108T94 DNA-binding transcriptional activator BglJ HLY11_10765 ENOG4108N8T regulatoR HLY11_10770 ENOG4105DWK Membrane HLY11_10785 ENOG4106CVF DNA replication protein HLY11_10790 ENOG4105RI1 glycoprotein receptor HLY11_10800 ENOG4105CPQ Dehydrogenase HLY11_10805 ENOG410617M Transcriptional regulator HLY11_10810 ENOG4108I5G Major Facilitator superfamily HLY11_10815 ENOG4105C8Q Methyl-accepting chemotaxis HLY11_10825 ENOG4105D22 carbon starvation protein HLY11_10830 ENOG4105VCD cytoplasmic protein HLY11_10835 ENOG4105CKI cobalamin synthesis protein HLY11_10860 ENOG4105CVR type I restriction-modification system HLY11_10880 ENOG4106DIZ Domain of unknown function (DUF1127) HLY11_10885 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HLY11_10900 ENOG41083G8 Multidrug resistance protein MdtM HLY11_10905 ENOG4106BRA Membrane HLY11_10910 ENOG4105DCU 2-hydroxyglutaryl-CoA dehydratase HLY11_10915 ENOG4105CIZ coA-substrate-specific enzyme activase HLY11_10930 ENOG4108ZK4 sdia-regulated domain-containing protein HLY11_10935 ENOG4105CBP Major Facilitator HLY11_10940 ENOG4105TNG K13735 adhesin invasin HLY11_10950 ENOG41074DU domain protein HLY11_10955 ENOG4108P2H Inner membrane protein YjiG HLY11_10960 ENOG4105DYB Isoaspartyl dipeptidase HLY11_10965 ENOG4107YNJ LysR family Transcriptional regulator HLY11_10985 ENOG4105C6F GntR Family Transcriptional Regulator HLY11_10990 ENOG4105DEI Mannitol dehydrogenase HLY11_11000 ENOG4105C4R Atp-dependent dna helicase HLY11_11005 ENOG4108I5C dEAD DEAH box helicase HLY11_11015 ENOG4105BZK Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair (By similarity) HLY11_11080 ENOG4108X3P Toxic component of a toxin-antitoxin (TA) module. Overexpression results in inhibition of growth in liquid cultures HLY11_11085 ENOG4105MAW Antitoxin component of a toxin-antitoxin (TA) module. Labile antitoxin that counteracts the effect of the CbtA (YeeV) toxin. It does not bind to the cognate toxin but instead binds to MreB and FtsZ (the toxin targets), enhancing their polymerization by forming higher-order bundles HLY11_11090 ENOG4108XS9 dna repair protein HLY11_11095 ENOG4106H6R UPF0380 protein HLY11_11120 ENOG4108MXD gtp-binding protein HLY11_11125 ENOG4108KZE transcriptional regulator HLY11_11130 ENOG4107SCJ type I restriction enzyme EcoKI subunit R HLY11_11170 ENOG4105DQ4 alcohol dehydrogenase HLY11_11175 ENOG4105D7A ATP-binding protein HLY11_11180 ENOG4108K5H permease YjgP YjgQ family protein HLY11_11185 ENOG4108M8S permease YjgP YjgQ family protein HLY11_11195 ENOG4105MYG DNA polymerase iii, chi subunit HLY11_11200 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) HLY11_11205 ENOG4108M3P Membrane HLY11_11210 ENOG4108MJ3 acetyltransferase HLY11_11215 ENOG4105KQT Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome (By similarity) HLY11_11230 ENOG4105XEP YhcH YjgK YiaL family protein HLY11_11235 ENOG4108XFH Transcriptional regulator HLY11_11240 ENOG4105F6U Short-chain dehydrogenase reductase Sdr HLY11_11245 ENOG4108UQ8 endoribonuclease L-psp HLY11_11250 ENOG4107C93 pyrBI operon leader peptide HLY11_11265 ENOG4105KME endoribonuclease L-psp HLY11_11270 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic HLY11_11280 ENOG4105D4X repressor HLY11_11285 ENOG4105C5Y PTS System HLY11_11290 ENOG4105CG3 alpha amylase, catalytic region HLY11_11295 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase HLY11_11300 ENOG4108RDD Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine (By similarity) HLY11_11305 ENOG4105K4U addiction module toxin, RelE StbE family HLY11_11320 ENOG4105CMS peptidase U62, modulator of DNA gyrase HLY11_11330 ENOG4105DFU Cell wall formation (By similarity) HLY11_11340 ENOG41062B0 ABC transporter, permease HLY11_11345 ENOG4107R9N ABC transporter HLY11_11350 ENOG4105C2J ABC transporter HLY11_11355 ENOG4107R5U Periplasmic binding protein LacI transcriptional regulator HLY11_11360 ENOG4105F0N pyrophosphate phospho-hydrolase HLY11_11365 ENOG4105MZG transcriptional modulator of maze toxin, mazf HLY11_11370 ENOG41087RY SpoVT_AbrB HLY11_11375 ENOG4108ZHD aig2 family HLY11_11380 ENOG4105MA0 exported protein HLY11_11385 ENOG4105CFU surface antigen HLY11_11395 ENOG4105C37 (CBS) domain HLY11_11400 ENOG41061GZ Protein of unknown function (DUF1107) HLY11_11405 ENOG4108UUE Transcriptional regulator HLY11_11415 ENOG4108RNI 3'(2')5'-bisphosphate nucleotidase HLY11_11420 ENOG4107RNS bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase 3'-nucleotidase periplasmic HLY11_11430 ENOG4105DXC membrane HLY11_11450 ENOG4105C85 amino acid HLY11_11455 ENOG4108V1T peptidylprolyl cis-trans isomerase HLY11_11460 ENOG4105FHY Opacity-associated protein A HLY11_11480 ENOG4107R0K CoA transferase having broad substrate specificity for short-chain acyl-CoA thioesters with the activity decreasing when the length of the carboxylic acid chain exceeds four carbons (By similarity) HLY11_11485 ENOG4107S3R L-aspartate oxidase HLY11_11490 ENOG4105DPW Major facilitator superfamily MFS_1 HLY11_11495 ENOG4108F01 MaoC domain protein HLY11_11515 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) HLY11_11530 ENOG4105KIT UPF0379 protein yjfY HLY11_11550 ENOG4106ETB IIa component HLY11_11555 ENOG410907W The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in ascorbate transport HLY11_11560 ENOG4105CZC PTS system ascorbate-specific transporter subunit IIC HLY11_11575 ENOG4108MXZ Esterase HLY11_11580 ENOG4105WSB biofilm stress and motility protein A HLY11_11585 ENOG4105S17 UPF0379 protein yjfN HLY11_11590 ENOG4105CSU acyl-Coa dehydrogenase HLY11_11595 ENOG4106032 Glutathionylspermidine synthase HLY11_11600 ENOG4108KXT Conserved Protein HLY11_11605 ENOG4105Z6B inner membrane protein yjfl HLY11_11610 ENOG4107VNS Protein of unknown function (DUF2491) HLY11_11615 ENOG4108P9J Phage shock protein A HLY11_11620 ENOG4105FUX Conserved Protein HLY11_11625 ENOG4105CTX dehydratase HLY11_11630 ENOG4105CSP Major Facilitator Superfamily HLY11_11635 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) HLY11_11640 ENOG4107HP6 Transcriptional regulator HLY11_11645 ENOG4105C2N RNA methyltransferase TrmH family group 3 HLY11_11650 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) HLY11_11670 ENOG4105EPW hflc protein HLY11_11675 ENOG4107QJR hflk protein HLY11_11680 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) HLY11_11700 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase HLY11_11705 ENOG4105K8N protein family UPF0079, ATPase HLY11_11710 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) HLY11_11715 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) HLY11_11755 ENOG4105EGS Mechanosensitive ion channel HLY11_11760 ENOG4107SC7 Inner membrane transporter yjeM HLY11_11770 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) HLY11_11775 ENOG4105E33 succinate dehydrogenase HLY11_11790 ENOG4105QNF Outer membrane lipoprotein HLY11_11795 ENOG4105KPY Small multidrug resistance protein HLY11_11800 ENOG4106BSU Entericidin B HLY11_11805 ENOG4107PEH Entericidin EcnA/B family HLY11_11815 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein HLY11_11820 ENOG4105MTB Uncharacterized protein YjeJ HLY11_11825 ENOG4108ZVF (LipO)protein HLY11_11840 ENOG4105DVH amino acid HLY11_11845 ENOG4108YH1 overproduction of this protein in Escherichia coli inhibits the F plasmid-mediated exclusion of bacteriophage T7 HLY11_11850 ENOG4108IJ0 Aspartate ammonia-lyase HLY11_11855 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter HLY11_11865 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) HLY11_11870 ENOG4108SIC Transcriptional regulator HLY11_11880 ENOG4108M3R transcriptional activator CadC HLY11_11885 ENOG4105D5Q Arginine ornithine antiporter HLY11_11890 ENOG4105CXN decarboxylase HLY11_11895 ENOG4105DUX Transporter HLY11_11900 ENOG4105CRK lysyL-tRNA synthetase HLY11_11915 ENOG410830R acetyltransferase HLY11_11920 ENOG4105VR1 Pfam:DUF1271 HLY11_11925 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism HLY11_11930 ENOG4108MRH transcriptional regulatory protein HLY11_11935 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter HLY11_11940 ENOG4107GFK fumarate HLY11_11945 ENOG4108R5S membrane HLY11_11950 ENOG4105F8D glycoside hydrolase family 4 HLY11_11955 ENOG4108K2B transcriptional regulator HLY11_11960 ENOG4105CXN decarboxylase HLY11_11965 ENOG4106ZGR Transcriptional regulator HLY11_11970 ENOG4105D5Q Arginine ornithine antiporter HLY11_11975 ENOG4105DIJ Phosphoethanolamine transferase HLY11_11980 ENOG4105XJC Two component transcriptional regulator (Winged helix family HLY11_11985 ENOG4105ECM Sensor protein basS pmrB HLY11_11995 ENOG4105CSH Transporter HLY11_12000 ENOG4108YIV HLY11_12005 ENOG4108F5E vimentin HLY11_12010 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA HLY11_12015 ENOG4108SQ4 Glyoxalase Bleomycin resistance protein (Dioxygenase HLY11_12020 ENOG410849A acetyltransferase, (GNAT) family HLY11_12025 ENOG4106ZVZ Escherichia coli IMT2125 genomic chromosome, IMT2125 HLY11_12035 ENOG4105C2J ABC transporter HLY11_12040 ENOG4105CNN ABC, transporter HLY11_12045 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator HLY11_12055 ENOG4105D2N Aldolase HLY11_12070 ENOG4105EUZ Beta-lactamase domain protein HLY11_12075 ENOG4106833 HLY11_12080 ENOG4105J12 Multidrug resistance protein mdtN HLY11_12085 ENOG4108MI0 Resistance protein HLY11_12090 ENOG4105ETP RND efflux system, outer membrane lipoprotein HLY11_12100 ENOG41082ND Uncharacterized protein yjcO HLY11_12110 ENOG4105CK2 sodium dicarboxylate symporter HLY11_12115 ENOG4108W0S formate-dependent nitrite reductase complex HLY11_12125 ENOG4108QKW cytochrome c-type biogenesis protein HLY11_12130 ENOG4105DVI reductase, NrfD HLY11_12135 ENOG4105D3S 4Fe-4S Ferredoxin, iron-sulfur binding domain protein HLY11_12140 ENOG4105JJ8 Cytochrome c nitrite reductase, pentaheme subunit HLY11_12150 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) HLY11_12155 ENOG41062QD Membrane HLY11_12170 ENOG4105EEQ Na H antiporter HLY11_12175 ENOG4105C7N Xanthine uracil vitamin C permease HLY11_12180 ENOG4108Z4X TRANSCRIPTIONal HLY11_12185 ENOG4108W3Q Transcriptional regulator HLY11_12190 ENOG4108M8H domain protein HLY11_12195 ENOG4105PMV Membrane HLY11_12205 ENOG4108UUM single-stranded DNA-binding protein HLY11_12210 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) HLY11_12215 ENOG4105MSB protein, conserved in bacteria HLY11_12220 ENOG4108YXI Secondary thiamine-phosphate synthase enzyme HLY11_12225 ENOG4105F0S class B acid phosphatase HLY11_12235 ENOG4105CGF Aromatic amino acid aminotransferase HLY11_12240 ENOG4107VZS Nicotinamide-nucleotide adenylyltransferase HLY11_12245 ENOG4106Z1T Nicotinamide Mononucleotide Transporter HLY11_12250 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) HLY11_12255 ENOG4105CDU Replicative dna helicase HLY11_12260 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein HLY11_12265 ENOG4105P4Z Phage shock protein G HLY11_12270 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) HLY11_12280 ENOG4105MYN Zinc uptake regulation protein HLY11_12285 ENOG4105VDW Csbd family HLY11_12290 ENOG4107R73 Mate efflux family protein HLY11_12300 ENOG41080IJ Diacylglycerol kinase HLY11_12325 ENOG4107W52 maltose operon periplasmic protein HLY11_12330 ENOG4108KDD Involved in the transport of maltose and maltodextrins (By similarity) HLY11_12335 ENOG4108IJ9 (ABC) transporter HLY11_12340 ENOG4107FKK extracellular solute-binding protein family 1 HLY11_12345 ENOG4105D56 permease protein HLY11_12350 ENOG4105EG2 ABC transporter, permease HLY11_12365 ENOG4105E3R (LipO)protein HLY11_12370 ENOG4108Q9C Periplasmic Protein HLY11_12375 ENOG4108MDC (LipO)protein HLY11_12385 ENOG4107QP8 phosphohexose isomerase HLY11_12390 ENOG4105CFH Aspartokinase HLY11_12395 ENOG4108ZR5 Conserved Protein HLY11_12400 ENOG4105FE9 pseudouridine synthase HLY11_12405 ENOG4105DKT Transcriptional regulator HLY11_12410 ENOG4105CHR reductase HLY11_12415 ENOG4108XCU pts system HLY11_12420 ENOG4105KPI PTS system sorbose subfamily IIB component HLY11_12425 ENOG4105ETZ PTS System HLY11_12430 ENOG4105F3R pts system mannose fructose sorbose family iid HLY11_12435 ENOG4105DXH Alcohol dehydrogenase zinc-binding domain protein HLY11_12445 ENOG4105EAM Na Pi-cotransporter HLY11_12450 ENOG4105C3R Methionine synthase HLY11_12455 ENOG41069M3 Transcriptional regulator HLY11_12460 ENOG4105VS7 Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation (By similarity) HLY11_12465 ENOG4108I9X Isocitrate lyase HLY11_12470 ENOG4107QP3 malate synthase g HLY11_12480 ENOG4105K5X acetyltransferase HLY11_12510 ENOG4105C12 Phosphoribosylglycinamide synthetase HLY11_12515 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family HLY11_12520 ENOG4105BZU Histidine kinase HLY11_12525 ENOG4105JBU Binds zinc. Could be an important component of the zinc- balancing mechanism HLY11_12530 ENOG4108T8B Protein of unknown function (DUF1481) HLY11_12540 ENOG4105R2J Conserved Protein HLY11_12565 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) HLY11_12575 ENOG4105D06 uba thif-type nad fad binding protein HLY11_12580 ENOG4105WHD thiamine biosynthesis protein ThiS HLY11_12590 ENOG4105D41 biosynthesis protein thiH HLY11_12595 ENOG410645W Thiamin biosynthesis protein ThiH HLY11_12630 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) HLY11_12635 ENOG4105PM1 preprotein translocase subunit SecE HLY11_12670 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase HLY11_12675 ENOG4105D4A Cell wall formation (By similarity) HLY11_12700 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) HLY11_12705 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) HLY11_12710 ENOG4107R9T Catalyzes the formation of 5-methyl-uridine at position 54 (m5U54) in all tRNAs (By similarity) HLY11_12715 ENOG4108Y73 Membrane HLY11_12720 ENOG4105EJ2 Transcriptional regulator HLY11_12730 ENOG4105C5Q Transcriptional regulator HLY11_12735 ENOG4108I5G Major Facilitator superfamily HLY11_12740 ENOG4105CXK mandelate racemase muconate lactonizing HLY11_12745 ENOG4105CH7 arginosuccinase HLY11_12755 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase HLY11_12770 ENOG4105DIJ Phosphoethanolamine transferase HLY11_12775 ENOG4106R3P AraC family transcriptional regulator HLY11_12780 ENOG4108XCZ PTS System HLY11_12785 ENOG4108AHH pyruvate formate lyase II activase HLY11_12795 ENOG4108YRF PTS System HLY11_12800 ENOG4105DM4 PTS System HLY11_12805 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) HLY11_12810 ENOG4107T9Z Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) HLY11_12815 ENOG4105DCT glycerol dehydrogenase HLY11_12820 ENOG4108XC3 NADH ubiquinone oxidoreductase HLY11_12825 ENOG4108Q5Y Membrane HLY11_12835 ENOG4105SYT Methylenetetrahydrofolate reductase HLY11_12840 ENOG4105CI1 PTS System HLY11_12845 ENOG4107P2S Transcriptional regulator HLY11_12855 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) HLY11_12865 ENOG4105CGH 5'-nucleotidase HLY11_12875 ENOG4105CFH Aspartokinase HLY11_12880 ENOG4105C28 cystathionine HLY11_12890 ENOG4107S01 Repressor protein MetJ HLY11_12900 ENOG4105C25 Primosomal protein n' HLY11_12905 ENOG4105ETE Transcriptional regulator (LacI family HLY11_12910 ENOG41063M6 Cell Division Protein HLY11_12925 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase HLY11_12950 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) HLY11_12960 ENOG4105CBT Fructose-1,6-bisphosphatase HLY11_12965 ENOG4105DP0 ferredoxin-NADP reductase HLY11_12975 ENOG41065TG regulatoR HLY11_12980 ENOG4108VTS Membrane HLY11_12985 ENOG4105EBK exported protein HLY11_13000 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein HLY11_13015 ENOG4105FMW periplasmic HLY11_13020 ENOG4105E3W Two component transcriptional regulator (Winged helix family HLY11_13025 ENOG4105E0F Histidine kinase HLY11_13030 ENOG4108RPX mosc domain containing protein HLY11_13040 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) HLY11_13065 ENOG4105DKG l-rhamnose isomerase HLY11_13085 ENOG41064BA PTS system, fructose-specific, IIA component HLY11_13090 ENOG4105DM4 PTS System HLY11_13095 ENOG4105CN9 Peptidase m42 family protein HLY11_13100 ENOG4106C3V frv operon regulatory protein HLY11_13105 ENOG4108V87 frv operon regulatory protein HLY11_13115 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) HLY11_13130 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein HLY11_13135 ENOG4108MG3 formate dehydrogenase HLY11_13145 ENOG41068KX affects formate dehydrogenase-N HLY11_13160 ENOG4105W2W Cytotoxic translational repressor of toxin-antitoxin stability system HLY11_13175 ENOG4105SUU thioesterase domain HLY11_13190 ENOG4105EJU HAD-superfamily hydrolase subfamily IA variant 3 HLY11_13195 ENOG4105E98 transcriptional regulator DeoR family HLY11_13200 ENOG4108MGF sugar kinase HLY11_13205 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase HLY11_13210 ENOG4105D2M Aldolase HLY11_13215 ENOG4107QKS N-acylglucosamine 2-epimerase HLY11_13220 ENOG4107WI4 Aldose-1-epimerase HLY11_13230 ENOG4105CJQ hydrolase, family 31 HLY11_13235 ENOG4105CT4 transporter HLY11_13240 ENOG4105CT4 transporter HLY11_13245 ENOG4108KUC Outer membrane channel protein that allows an efficient diffusion of low-molecular-weight solutes such as small sugars and tetraglycine. However, the specific substrate recognized by the OmpL channel is HLY11_13265 ENOG4105CSA Coproporphyrinogen iii oxidase HLY11_13275 ENOG4108K4B hydrolase HLY11_13280 ENOG4105CI3 gtp-binding protein typa HLY11_13285 ENOG4105C5F glutamine synthetase HLY11_13290 ENOG4105CUX Signal transduction histidine kinase HLY11_13295 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family HLY11_13300 ENOG4106FIY HLY11_13305 ENOG4105D4P Coproporphyrinogen iii oxidase HLY11_13320 ENOG4105C2M dna polymerase I HLY11_13325 ENOG4106HNH Acyl-transferase HLY11_13335 ENOG4108Z33 Thiol disulfide Interchange Protein HLY11_13340 ENOG4105E27 serine threonine protein kinase HLY11_13345 ENOG4105PC1 Conserved Protein HLY11_13350 ENOG4105C6R Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) HLY11_13355 ENOG4105FNP Molybdopterin-guanine dinucleotide biosynthesis protein b HLY11_13385 ENOG4108RR8 protoporphyrinogen oxidase HLY11_13390 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) HLY11_13395 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein HLY11_13415 ENOG4108EX3 reductase HLY11_13420 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) HLY11_13425 ENOG4105MDZ Transcriptional activator rfaH HLY11_13435 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) HLY11_13440 ENOG4105X8U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity) HLY11_13445 ENOG4105WKS Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) HLY11_13455 ENOG4105JC1 sterol-binding domain protein HLY11_13465 ENOG4105CGY Dna recombination protein HLY11_13470 ENOG4108I5U Uridine phosphorylase HLY11_13475 ENOG4105CDZ Carboxymethylenebutenolidase (EC 3.1.1.45) HLY11_13480 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) HLY11_13485 ENOG4105DZ2 Transcriptional regulator HLY11_13490 ENOG4105EMK carboxylate amino acid amine transporter HLY11_13495 ENOG4105DQF Hydrolase HLY11_13500 ENOG4108EUD Lysophospholipase HLY11_13505 ENOG410829K Lysine exporter protein (Lyse ygga) HLY11_13510 ENOG4105CCF Lysine exporter protein (Lyse ygga) HLY11_13515 ENOG4105C9U ATP-dependent DNA helicase RecQ HLY11_13525 ENOG4105HDD phospholipase HLY11_13530 ENOG4108VUY thioesterase Superfamily protein HLY11_13535 ENOG4105FR1 rard protein HLY11_13545 ENOG4107QUT magnesium and cobalt transport protein CorA HLY11_13550 ENOG4108T58 Mg2 transport protein CorA HLY11_13555 ENOG4105C4R Atp-dependent dna helicase HLY11_13560 ENOG4105DFC had-superfamily hydrolase, subfamily ia, variant HLY11_13570 ENOG4105CT0 Protein of unknown function, DUF484 HLY11_13580 ENOG4105S7Z (LipO)protein HLY11_13600 ENOG4107T0K Adenylate cyclase HLY11_13610 ENOG41076E6 Uroporphyrinogen-III Synthase HLY11_13615 ENOG4105ECF c-methyltransferase HLY11_13620 ENOG410601J HemY protein HLY11_13630 ENOG4105ENH Sulfatase HLY11_13635 ENOG4105C4X radical SAM domain protein HLY11_13660 ENOG4105C85 amino acid HLY11_13675 ENOG4105F18 Catalyzes the synthesis of Und-PP-GlcNAc-ManNAcA-Fuc4NAc (Lipid III), the third lipid-linked intermediate involved in ECA synthesis (By similarity) HLY11_13680 ENOG4105EGZ biosynthesis protein HLY11_13685 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase HLY11_13690 ENOG4108WJ1 acetyltransferase HLY11_13695 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) HLY11_13700 ENOG4105C1B dTDP-glucose 4-6-dehydratase HLY11_13705 ENOG4107QQG Dehydrogenase HLY11_13710 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase HLY11_13715 ENOG4105SFE lipopolysaccharide biosynthesis protein HLY11_13720 ENOG4105ESV Glycosyl transferase, family 4 HLY11_13725 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) HLY11_13750 ENOG4105C4R Atp-dependent dna helicase HLY11_13760 ENOG4105KQ5 peptidylprolyl cis-trans isomerase HLY11_13770 ENOG4105EMY transcriptional regulator HLY11_13775 ENOG4105C7B Threonine dehydratase HLY11_13785 ENOG4105CM2 brancheD-chain amino acid aminotransferase HLY11_13790 ENOG4105P3Y Acetolactate synthase 2 regulatory subunit HLY11_13810 ENOG4105C0P Mg chelatase subunit ChlI HLY11_13815 ENOG4108WFC UPF0438 protein yifE HLY11_13855 ENOG4107EJG GntR family transcriptional regulator HLY11_13860 ENOG4105C0R drug resistance transporter emrb qaca subfamily HLY11_13865 ENOG4105ETE Transcriptional regulator (LacI family HLY11_13870 ENOG4108RVA ribokinase HLY11_13875 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator HLY11_13880 ENOG4105CNN ABC, transporter HLY11_13885 ENOG4105C2J ABC transporter HLY11_13890 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) HLY11_13905 ENOG4105EV2 VWA domain protein interacting with AAA ATPase HLY11_13915 ENOG4108VVK transcriptional Regulator, AsnC HLY11_13920 ENOG4105QTB Flavodoxin HLY11_13935 ENOG4105GXX Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit I associates with the membrane and may be involved with cation translocation HLY11_13985 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) HLY11_13990 ENOG4107QMV Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity) HLY11_13995 ENOG4105C8U phosphate abc transporter HLY11_14000 ENOG4105E2Z phosphate ABC transporter (Permease HLY11_14005 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) HLY11_14010 ENOG4108UTW Plays a role in the regulation of phosphate uptake HLY11_14020 ENOG4105UMR response to DNA damage stimulus HLY11_14025 ENOG4105UMR response to DNA damage stimulus HLY11_14030 ENOG4108S1B Periplasmic chaperone protein HLY11_14035 ENOG4105E6S usher protein( HLY11_14065 ENOG4107UB3 HAD-superfamily hydrolase subfamily IA variant 3 HLY11_14070 ENOG4105C7N Xanthine uracil vitamin C permease HLY11_14075 ENOG4108YYH Nadph-dependent fmn reductase HLY11_14080 ENOG4105E8Q phosphopantetheinyl transferase HLY11_14095 ENOG4108P6C Tryptophan transporter of low affinity HLY11_14135 ENOG4105VG0 50S ribosomal protein l34 HLY11_14150 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) HLY11_14160 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HLY11_14165 ENOG4105VP5 Bacterial protein of unknown function (DUF937) HLY11_14170 ENOG410667J hydrolase HLY11_14175 ENOG410657R replicase EC 2.7 HLY11_14180 ENOG4105EMF GntR family transcriptional regulator HLY11_14185 ENOG4105EI3 2-dehydro-3-deoxygalactonokinase EC 2.7.1.58 HLY11_14190 ENOG4108RTU Aldolase HLY11_14200 ENOG4105DJB Major Facilitator Superfamily HLY11_14210 ENOG4105D99 atp gtp-binding protein HLY11_14215 ENOG4105R2A (LipO)protein HLY11_14235 ENOG4105FDP GntR family transcriptional regulator HLY11_14240 ENOG4105CI1 PTS System HLY11_14245 ENOG4105F8D glycoside hydrolase family 4 HLY11_14250 ENOG4108AHD Transcriptional regulator HLY11_14255 ENOG4107RUZ Sss sodium solute transporter superfamily HLY11_14260 ENOG4105CBG Sulfatase HLY11_14265 ENOG4106DRA Inner membrane protein YidI HLY11_14270 ENOG4105VG5 Membrane HLY11_14275 ENOG4105JP4 Inner membrane protein yidG HLY11_14280 ENOG4105J13 transcriptional regulator HLY11_14285 ENOG4105E5M Multidrug resistance protein D HLY11_14300 ENOG4105C7K acetolactate synthase HLY11_14305 ENOG4105M71 acetolactate synthase 1 regulatory subunit HLY11_14320 ENOG4108KX4 response regulator HLY11_14325 ENOG4105BZU Histidine kinase HLY11_14330 ENOG4105CXY transporter HLY11_14335 ENOG4105CXY transporter HLY11_14345 ENOG4105C7N Xanthine uracil vitamin C permease HLY11_14350 ENOG4108SAJ Protein of unknown function (DUF1198) HLY11_14370 ENOG4105TNG K13735 adhesin invasin HLY11_14375 ENOG4108YAB Invasion protein HLY11_14380 ENOG4105IBT Required for translocation of effector proteins via the type III secretion system SPI-1, which is essential for an efficient bacterial internalization. Probably acts by modulating the secretion of SipA, SipB, and SipC HLY11_14405 ENOG4105T8A Uncharacterized protein YicS HLY11_14410 ENOG4105D01 (LipO)protein HLY11_14415 ENOG4108UZ3 Transporter HLY11_14420 ENOG4105S8Q sugar efflux transporter HLY11_14435 ENOG4105CT4 transporter HLY11_14440 ENOG4105CJQ hydrolase, family 31 HLY11_14445 ENOG4105JV1 AsmA family HLY11_14450 ENOG4105C2W permease HLY11_14455 ENOG4105D6U Sodium Glutamate Symporter HLY11_14460 ENOG4105CB5 ATP-dependent DNA helicase recG HLY11_14465 ENOG4105FE8 tRNA (Guanosine-2'-O-)-methyltransferase HLY11_14470 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) HLY11_14480 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) HLY11_14490 ENOG4105EN6 Membrane HLY11_14495 ENOG4105F5P DNA-damage-inducible protein d HLY11_14500 ENOG4105DSJ YicC domain protein HLY11_14520 ENOG4108Z1K This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) HLY11_14525 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase HLY11_14535 ENOG4105KDC 50s ribosomal protein l28 HLY11_14545 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) HLY11_14555 ENOG4105D8A 3-Deoxy-D-manno-octulosonic-acid transferase HLY11_14560 ENOG4105DKP glycosyl transferase, family 9 HLY11_14565 ENOG4107RJ7 Glycosyl transferase (Group 1 HLY11_14570 ENOG4107543 (lipo)polysaccharide HLY11_14575 ENOG4105X1N Glycosyl transferase family 8 HLY11_14580 ENOG4107XU6 Glycosyl transferase (Group 1 HLY11_14585 ENOG4106AH0 Glycosyl Transferase HLY11_14590 ENOG4105X1N Glycosyl transferase family 8 HLY11_14595 ENOG4108PDR lipopolysaccharide core biosynthesis protein HLY11_14600 ENOG4108QD8 lipopolysaccharide core biosynthesis protein HLY11_14605 ENOG4108XNZ glycosyl transferase HLY11_14610 ENOG41068PG O-Antigen polymerase HLY11_14615 ENOG4105D16 lipopolysaccharide heptosyltransferase i HLY11_14620 ENOG4105XA0 heptosyltransferase ii HLY11_14630 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) HLY11_14640 ENOG4105K64 Glycosyl transferase, family 2 HLY11_14645 ENOG4105PXI polysaccharide deacetylase HLY11_14650 ENOG41063SB peptidase HLY11_14660 ENOG4107YZP Rhodanese domain protein HLY11_14665 ENOG4105VW4 glutaredoxin 3 HLY11_14680 ENOG4105D7W serine acetyltransferase HLY11_14685 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) HLY11_14695 ENOG41073TP transcriptional regulator HLY11_14700 ENOG4105DAA L-lactate HLY11_14705 ENOG4105EUR Domain-Containing protein HLY11_14710 ENOG4108WY4 inner membrane lipoprotein HLY11_14715 ENOG4108YYI Protein of unknown function (DUF2810) HLY11_14725 ENOG4105E61 Mannitol repressor protein HLY11_14735 ENOG4105CTS PTS system mannitol-specific HLY11_14740 ENOG4105FP6 Protein of unknown function (DUF3302) HLY11_14745 ENOG4105EFX secretion protein, HlyD family HLY11_14750 ENOG4108U78 Glutathione S-transferase HLY11_14760 ENOG4105EM7 Selenocysteine-specific translation elongation factor HLY11_14770 ENOG4105C26 Dehydrogenase HLY11_14780 ENOG4105KK7 inner membrane protein YiaW HLY11_14785 ENOG4105EFX secretion protein, HlyD family HLY11_14790 ENOG4108Q2M Transcriptional regulator HLY11_14795 ENOG4105GNX MltA-interacting MipA family protein HLY11_14805 ENOG4105CT4 transporter HLY11_14815 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase HLY11_14820 ENOG41064BZ L-xylulose 5-phosphate 3-epimerase HLY11_14825 ENOG4105H6Q decarboxylase HLY11_14830 ENOG4105CMG Carbohydrate kinase HLY11_14835 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit HLY11_14840 ENOG4105CG6 trap dicarboxylate transporter dctm subunit HLY11_14845 ENOG4105XDZ Tripartite ATP-independent periplasmic transporter HLY11_14850 ENOG4108R66 Conserved Protein HLY11_14860 ENOG4105J4Q Transcriptional regulator HLY11_14865 ENOG4108XIB electron transport protein ysaA HLY11_14870 ENOG4105JKW Valine--pyruvate aminotransferase HLY11_14875 ENOG4107T9C Alpha amylase catalytic region HLY11_14880 ENOG4108UR8 BAX protein HLY11_14885 ENOG4105T16 Transcriptional regulator (AraC family) HLY11_14890 ENOG4108HWW ABC transporter HLY11_14900 ENOG4105DFW ABC transporter HLY11_14910 ENOG4105CMG Carbohydrate kinase HLY11_14915 ENOG410688U Inner membrane protein yiaB HLY11_14920 ENOG4108Z12 YiaAB two helix domain-containing protein HLY11_14925 ENOG4105MEV Acyl-transferase HLY11_14970 ENOG4105MVF Transcriptional regulator HLY11_14975 ENOG4106JH6 (LipO)protein HLY11_14985 ENOG4108ZG0 Ompa motb domain protein HLY11_14990 ENOG4107QY8 reductase HLY11_14995 ENOG4105HNP -acetyltransferase HLY11_15000 ENOG4108R3E Dna-3-methyladenine glycosylase i HLY11_15005 ENOG4105EAX Putative lipase HLY11_15010 ENOG4105FCD Major Facilitator HLY11_15015 ENOG4106EAR Fimbrial protein HLY11_15020 ENOG4108VCD Chaperone HLY11_15025 ENOG4105CW0 outer membrane usher protein HLY11_15030 ENOG4105MHR Fimbrial protein HLY11_15035 ENOG4106UCC Fimbrial protein HLY11_15040 ENOG4105DIJ Phosphoethanolamine transferase HLY11_15050 ENOG4105DEF Extracellular solute-binding protein, family 5 HLY11_15055 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HLY11_15060 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HLY11_15065 ENOG4105C3U ABC transporter HLY11_15070 ENOG4108JQ7 (ABC) transporter HLY11_15075 ENOG4105C44 Serine transporter HLY11_15095 ENOG4105D1V cellulose synthase operon protein YhjU HLY11_15100 ENOG4105WQA Cellulose biosynthesis protein BcsF HLY11_15105 ENOG4105U74 cellulose biosynthesis protein BcsE HLY11_15110 ENOG410661M cytoplasmic protein HLY11_15120 ENOG4107QZ7 Cellulose synthase catalytic subunit HLY11_15125 ENOG4107EEX Cellulose synthase regulator protein HLY11_15130 ENOG4105K2Z endo-1,4-d-glucanase (EC 3.2.1.4) HLY11_15135 ENOG4105EJG cellulose synthase HLY11_15140 ENOG4105BZU Histidine kinase HLY11_15150 ENOG4105CS0 peptidase HLY11_15180 ENOG4107SS6 2-dehydro-3-deoxygluconokinase HLY11_15185 ENOG4105CMB EAL domain-containing protein HLY11_15190 ENOG41066T0 asmA family HLY11_15195 ENOG4105CSH Transporter HLY11_15200 ENOG4107H3J ribonuclease HLY11_15205 ENOG4105CBN LysR family transcriptional regulator HLY11_15210 ENOG4106S2D Transcriptional regulator HLY11_15220 ENOG4105CA0 peroxidase HLY11_15225 ENOG4105CVK Glutamate decarboxylase HLY11_15230 ENOG4108NKV transcriptional regulator HLY11_15240 ENOG4105BZS acriflavin resistance protein HLY11_15245 ENOG4105C1P efflux transporter, rnd family, mfp subunit HLY11_15255 ENOG4106WJ0 Regulates the expression of several genes involved in acid resistance. Required for the expression of gadA and gadBC, among others, regardless of media or growth conditions. Binds directly to the 20 bp GAD box found in the control regions of both loci HLY11_15260 ENOG4108YK4 Acid-resistance membrane protein HLY11_15265 ENOG41060V2 Acid-resistance protein HLY11_15270 ENOG4105XXV Acid-resistance protein HLY11_15275 ENOG4105KT7 mgtC SapB transporter HLY11_15285 ENOG4105Y4Z Outer Membrane Lipoprotein HLY11_15295 ENOG4105K89 arsenate reductase HLY11_15300 ENOG4107R5R arsenical pump membrane protein HLY11_15305 ENOG4105KBH arsR family transcriptional regulator HLY11_15310 ENOG4105D7V transposase HLY11_15315 ENOG4108RS6 transposase HLY11_15325 ENOG4105DC8 reductase HLY11_15330 ENOG4105D6S protein involved in catabolism of external DNA HLY11_15335 ENOG4105DGW oligopeptidase A HLY11_15345 ENOG4105DUX Transporter HLY11_15360 ENOG4105CJ3 phosphate transporter HLY11_15365 ENOG4105CBX hi0933 family HLY11_15370 ENOG4107UNS conserved inner membrane protein HLY11_15385 ENOG4105D0S secretion protein (HlyD HLY11_15390 ENOG4105CJ1 ABC, transporter HLY11_15395 ENOG4105CMI transporter HLY11_15420 ENOG4106665 Part of the ABC transporter complex NikABCDE involved in nickel import. Responsible for energy coupling to the transport system (By similarity) HLY11_15425 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HLY11_15430 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HLY11_15435 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein HLY11_15440 ENOG4107YAK holo-(acyl carrier protein) synthase 2 HLY11_15445 ENOG4105DSF transport protein HLY11_15450 ENOG4105F9N Major Facilitator Superfamily HLY11_15455 ENOG4108W1V Lipoprotein HLY11_15460 ENOG4105EX9 Membrane HLY11_15485 ENOG4107FS9 Membrane HLY11_15495 ENOG4105MG3 Membrane HLY11_15500 ENOG4106H78 methyltransferase HLY11_15505 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) HLY11_15510 ENOG4105CAK Cell division ATP-binding protein ftsE HLY11_15515 ENOG4105CRP Part of the ABC transporter FtsEX involved in HLY11_15520 ENOG4105DEK Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HLY11_15525 ENOG4105CP9 extracellular ligand-binding receptor HLY11_15540 ENOG4105U59 -acetyltransferase HLY11_15545 ENOG4105CP9 extracellular ligand-binding receptor HLY11_15550 ENOG4105C32 Amino acid ABC transporter (Permease) HLY11_15555 ENOG4105CF8 branched-chain amino acid ABC transporter, permease HLY11_15560 ENOG4105C0Z ABC transporter HLY11_15565 ENOG4108IV0 ABC, transporter HLY11_15575 ENOG4105BZ7 extracellular solute-binding protein family 1 HLY11_15580 ENOG4105E4X binding-protein-dependent transport systems inner membrane Component HLY11_15585 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component HLY11_15595 ENOG4107T6V glycerophosphoryl diester phosphodiesterase HLY11_15600 ENOG4105WC8 Conserved Protein HLY11_15605 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) HLY11_15610 ENOG4105WCN acetyltransferase HLY11_15615 ENOG4105D9R oxidoreductase HLY11_15620 ENOG4105C2I pirin domain protein HLY11_15625 ENOG4105DIQ Transcriptional regulator HLY11_15630 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family HLY11_15635 ENOG4105C6Z Gluconate HLY11_15640 ENOG4105C9U ATP-dependent DNA helicase RecQ HLY11_15650 ENOG41076UM multiple antibiotic resistance (MarC)-related protein HLY11_15655 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) HLY11_15680 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) HLY11_15725 ENOG4105C6V Glycerol-3-phosphate dehydrogenase HLY11_15740 ENOG4105E98 transcriptional regulator DeoR family HLY11_15745 ENOG4105CYB regulatoR HLY11_15750 ENOG4105E0Y RtcB Protein HLY11_15775 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) HLY11_15780 ENOG4107RTM 4-alpha-glucanotransferase (EC 2.4.1.25) HLY11_15785 ENOG4105C6Z Gluconate HLY11_15795 ENOG4105MJ2 Competence protein HLY11_15815 ENOG4105CE1 Ferrous iron transport protein b HLY11_15820 ENOG4105XFK Ferrous iron transport protein A HLY11_15825 ENOG4105BZM domain protein HLY11_15830 ENOG4108RRZ Transcription elongation factor GreB HLY11_15840 ENOG4105E0F Histidine kinase HLY11_15860 ENOG4108MAJ Membrane HLY11_15870 ENOG4105VEJ Heat shock protein HLY11_15875 ENOG4107Y3D HAD-superfamily hydrolase subfamily IA variant 3 HLY11_15880 ENOG4105DQY intracellular growth attenuator HLY11_15885 ENOG4107RK2 ADP-ribose diphosphatase NudE HLY11_15890 ENOG4108JQC penicillin-binding protein 1A HLY11_15895 ENOG4108U1Q Pilus assembly protein HLY11_15900 ENOG41065NF Fimbrial assembly family protein HLY11_15905 ENOG4105XPX DNA utilization protein HofO HLY11_15910 ENOG4105ITY Required for the use of extracellular DNA as a nutrient HLY11_15915 ENOG4105E4G Type IV pilus HLY11_15930 ENOG4105EGB membrane protein DamX HLY11_15935 ENOG4105DFE Dna adenine methylase HLY11_15940 ENOG4105DJV ribulose-phosphate 3-epimerase HLY11_15945 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) HLY11_15950 ENOG4105C31 Tryptophanyl-tRNA synthetase HLY11_15955 ENOG4108M21 HLY11_15960 ENOG4105RMW regulation of transcription, DNA-dependent HLY11_15965 ENOG4108626 Racemase HLY11_15970 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) HLY11_15975 ENOG41080QX K07048 phosphotriesterase-related protein HLY11_15980 ENOG4105MUZ Protein of unknown function DUF2620 HLY11_15985 ENOG4106M0N transport system permease protein HLY11_15990 ENOG4106PKC pyridoxal phosphate binding HLY11_15995 ENOG4105FDP GntR family transcriptional regulator HLY11_16000 ENOG4108KPW sugar kinase HLY11_16005 ENOG4107Y0V Not clear, may be involved in an isomerization step HLY11_16010 ENOG4107R1S catalyzes the conversion of fructoselysine 6-phosphate to glucose 6-phosphate and lysine HLY11_16015 ENOG4107QHQ amino acid HLY11_16020 ENOG4105VYH HLY11_16030 ENOG4107V9H nitrite transporter HLY11_16035 ENOG4105WZK nitrite reductase NADPH small subunit HLY11_16040 ENOG4107QZF nitrite reductase NADPH large subunit HLY11_16050 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) HLY11_16060 ENOG4105MZU cell filamentation protein HLY11_16065 ENOG4105DDQ anthranilate synthase HLY11_16070 ENOG4105C8Y Acetylornithine aminotransferase HLY11_16075 ENOG410613R integral membrane protein, YccS YhfK family HLY11_16085 ENOG4108UKZ OsmC family HLY11_16090 ENOG4105CJE phosphoribulokinase (EC 2.7.1.19) HLY11_16100 ENOG4105DNZ Alpha Beta Hydrolase HLY11_16105 ENOG4105C5H ABC transporter HLY11_16120 ENOG4105VKU nucleicacid-binding protein HLY11_16125 ENOG4108YZY peptidylprolyl cis-trans isomerase HLY11_16135 ENOG4108V1T peptidylprolyl cis-trans isomerase HLY11_16140 ENOG4105WWK YheO domain protein HLY11_16180 ENOG4108NNZ chitinase HLY11_16185 ENOG4105W53 bacterioferritin-associated ferredoxin HLY11_16190 ENOG4108UQY Iron-storage protein HLY11_16195 ENOG4105EHH Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue (By similarity) HLY11_16205 ENOG41063JA Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins (By similarity) HLY11_16210 ENOG4105R04 type II secretion system protein K HLY11_16225 ENOG41069X0 general secretion pathway protein h HLY11_16230 ENOG4108VAU general secretion pathway protein G HLY11_16235 ENOG4105D7Q type ii secretion system HLY11_16240 ENOG4107QHF type ii secretion system protein e HLY11_16245 ENOG4105GVR general secretion pathway protein D HLY11_16250 ENOG4107KSE General secretion pathway protein C HLY11_16255 ENOG410899B May play a regulatory role under conditions of derepressed gsp gene expression HLY11_16260 ENOG4107ACA Calcium-binding protein required for initiation of chromosome replication HLY11_16280 ENOG41080KG One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) HLY11_16325 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) HLY11_16370 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) HLY11_16375 ENOG41067V7 50S ribosomal protein L36 HLY11_16405 ENOG4105VTS DnaJ-like, subfamily C HLY11_16410 ENOG4105W1Y Transcriptional regulator HLY11_16415 ENOG4105VCN Rescues the ribosomes stalled at the 3' end of non-stop mRNAs. May induce hydrolysis of the ribosome-bound peptidyl-tRNA. This activity is crucial when the stalled ribosome can not be rescued by the SsrA(tmRNA)-SmpB quality control system HLY11_16425 ENOG4105C1A potassium transporter peripheral membrane HLY11_16445 ENOG4105C79 DNA protecting protein DprA HLY11_16455 ENOG4108WI1 Dna topoisomerase HLY11_16470 ENOG4105SG3 Protein of unknown function (DUF1488) HLY11_16475 ENOG4108Z0R Transferase HLY11_16515 ENOG4105CDA abc transporter atp-binding protein HLY11_16520 ENOG4105DRP amino acid AbC transporter HLY11_16525 ENOG4105EZ7 amino acid ABC transporter HLY11_16535 ENOG4105XCM membrane LIPOPROTEIN HLY11_16540 ENOG4105BZS acriflavin resistance protein HLY11_16545 ENOG4105C1P efflux transporter, rnd family, mfp subunit HLY11_16550 ENOG4108XG4 DNA-binding transcriptional regulator HLY11_16555 ENOG41061ME transport protein HLY11_16560 ENOG4105CEC DNA methylase N-4 N-6 HLY11_16570 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) HLY11_16580 ENOG4108IA2 Sodium pantothenate symporter HLY11_16585 ENOG4105RG0 Membrane HLY11_16590 ENOG4107UEK pfkb domain protein HLY11_16595 ENOG4105E98 transcriptional regulator DeoR family HLY11_16600 ENOG4105D2N Aldolase HLY11_16605 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator HLY11_16610 ENOG4105C2J ABC transporter HLY11_16615 ENOG4105CNN ABC, transporter HLY11_16620 ENOG4107UEK pfkb domain protein HLY11_16630 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase HLY11_16635 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein HLY11_16645 ENOG4105D3Z quinone oxidoreductase, yhdh yhfp family HLY11_16650 ENOG41062P1 Diguanylate cyclase phosphodiesterase HLY11_16660 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) HLY11_16665 ENOG4105VQ7 Rod shape-determining protein MreD HLY11_16675 ENOG4105C03 ribonuclease HLY11_16680 ENOG4105QD6 exported protein HLY11_16685 ENOG4105D1U peptidase U62 modulator of DNA gyrase HLY11_16690 ENOG4105CR8 Transcriptional regulator HLY11_16695 ENOG4105ZQC membrane protein AaeX HLY11_16710 ENOG4105UNR (Barnase) inhibitor HLY11_16715 ENOG4105RID UPF0379 protein yhcN HLY11_16730 ENOG4105C0H protease HLY11_16735 ENOG4105C0H protease HLY11_16740 ENOG4108W2Q Cytochrome d ubiquinol oxidase subunit III HLY11_16745 ENOG4105D6Z AFG1 family ATPase HLY11_16760 ENOG4107MKT Stringent starvation protein a HLY11_16765 ENOG4105KB2 stringent starvation protein b HLY11_16770 ENOG4105CEE C4-dicarboxylate transporter HLY11_16785 ENOG4105JHE Major Facilitator Superfamily HLY11_16800 ENOG4108R66 Conserved Protein HLY11_16805 ENOG4105DFS Conserved Protein HLY11_16810 ENOG4105BZ8 glutamate synthase HLY11_16815 ENOG4105CBC glutamate synthase HLY11_16820 ENOG4105N5T Radical SAM Protein HLY11_16825 ENOG4105BZU Histidine kinase HLY11_16830 ENOG4108556 Isoprenoid biosynthesis protein with amidotransferase-like domain HLY11_16840 ENOG4108NIH transferase activity, transferring phosphorus-containing groups HLY11_16845 ENOG41080Z8 PHOSPHOCARRIER protein HLY11_16855 ENOG4107RM2 PTS IIA-like nitrogen-regulatory protein PtsN HLY11_16860 ENOG41080QH sigma 54 modulation protein ribosomal protein S30EA HLY11_16865 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HLY11_16870 ENOG4108IUZ ABC transporter HLY11_16875 ENOG4105WI0 lipopolysaccharide transport periplasmic protein lptA HLY11_16880 ENOG4108P1K Required for the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane (By similarity) HLY11_16885 ENOG4108Z4R 3-deoxy-d-manno-octulosonate 8-phosphate phosphatase HLY11_16890 ENOG4105C2X Arabinose 5-phosphate isomerase HLY11_16895 ENOG4105FEU K -dependent Na -Ca exchanger HLY11_16900 ENOG4105DHJ ABC, transporter HLY11_16905 ENOG4105CY3 ABC transporter, permease HLY11_16910 ENOG4107PE3 Mammalian cell entry related domain protein HLY11_16915 ENOG4105E3I toluene tolerance HLY11_16920 ENOG4105UE2 Part of the ABC transporter complex MlaFEDB that actively prevents phospholipid accumulation at the cell surface. Probably maintains lipid asymmetry in the outer membrane by retrograde trafficking of phospholipids from the outer membrane to the inner membrane HLY11_16925 ENOG4105VFK BolA family HLY11_16935 ENOG4105HVQ Regulatory factor of maltose metabolism HLY11_16940 ENOG4105EAH synthase HLY11_16955 ENOG4105QYV Membrane HLY11_16965 ENOG4106HRJ d-alanyl-d-alanine carboxypeptidase HLY11_16970 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) HLY11_16975 ENOG4105HBR Rna-binding protein HLY11_16985 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) HLY11_16990 ENOG4105EEI dihydropteroate synthase HLY11_17000 ENOG4105NTZ Preprotein translocase subunit SecG HLY11_17010 ENOG4105DIJ Phosphoethanolamine transferase HLY11_17030 ENOG4105CHV Transcription elongation factor NusA HLY11_17070 ENOG4105C1J atp-dependent rna helicase HLY11_17075 ENOG4105CIC tryptophan-specific transport protein HLY11_17080 ENOG4105DEN Luciferase family HLY11_17100 ENOG4108YYD acetyltransferase HLY11_17115 ENOG4107R7Y intracellular protease Pfpi family HLY11_17120 ENOG4105K4T epimerase HLY11_17125 ENOG4107S21 permease HLY11_17130 ENOG4105W4M Transport-associated protein HLY11_17145 ENOG4105E1C Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1A (PBP1a) (By similarity) HLY11_17150 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) HLY11_17165 ENOG4106HBN Galactosamine-6-phosphate isomerase HLY11_17170 ENOG4105F3R pts system mannose fructose sorbose family iid HLY11_17175 ENOG4105ETZ PTS System HLY11_17180 ENOG4108UZY PTS System HLY11_17190 ENOG4105E70 isomerase HLY11_17195 ENOG4105CE4 GlcNAc 6-P deacetylase HLY11_17200 ENOG4108YTN IIa component HLY11_17205 ENOG4105F3R pts system mannose fructose sorbose family iid HLY11_17215 ENOG4108RG5 PTS system N-acetylgalactosamine-specific transporter subunit IIB HLY11_17225 ENOG4105E98 transcriptional regulator DeoR family HLY11_17235 ENOG4105ZEG Suppressor protein HLY11_17240 ENOG4105E98 transcriptional regulator DeoR family HLY11_17245 ENOG4105EZX Catalyzes the phosphorylation of N-acetyl-D-glucosamine (GlcNAc) derived from cell-wall degradation, yielding GlcNAc-6-P (By similarity) HLY11_17260 ENOG4105F8D glycoside hydrolase family 4 HLY11_17265 ENOG4105CK1 PTS System HLY11_17270 ENOG4105VZJ PTS System HLY11_17275 ENOG4105CTX dehydratase HLY11_17280 ENOG4105DJB Major Facilitator Superfamily HLY11_17290 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase HLY11_17295 ENOG4105BZW Glycerate kinase HLY11_17320 ENOG410811B TRANSCRIPTIONal HLY11_17325 ENOG4105C7B Threonine dehydratase HLY11_17335 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) HLY11_17340 ENOG4105C6N Formate acetyltransferase HLY11_17345 ENOG4105KME endoribonuclease L-psp HLY11_17350 ENOG4105EJQ L-serine dehydratase HLY11_17355 ENOG4105C44 Serine transporter HLY11_17365 ENOG4106D80 Uncharacterized protein YhaL HLY11_17370 ENOG4108CNN domain protein HLY11_17375 ENOG4105CWB LysR family transcriptional Regulator HLY11_17380 ENOG4105KAF membrAne HLY11_17385 ENOG4105CHF Glutathione S-transferase HLY11_17390 ENOG4108VBZ doxx family HLY11_17395 ENOG4105YJD HLY11_17400 ENOG41090KG Inner membrane protein YqjE HLY11_17405 ENOG4105NE1 Conserved Protein HLY11_17410 ENOG4105WAY exported protein HLY11_17415 ENOG4105IYR Modulates the activity of the EnvZ OmpR two-component regulatory system, probably by directly modulating EnvZ enzymatic activity and increasing stability of phosphorylated OmpR (By similarity) HLY11_17420 ENOG4106W5V Membrane HLY11_17425 ENOG4107YCY Transcriptional regulator HLY11_17450 ENOG4105DPW Major facilitator superfamily MFS_1 HLY11_17460 ENOG4105CTX dehydratase HLY11_17465 ENOG4105P66 Membrane HLY11_17470 ENOG4107QV7 Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system) (By similarity) HLY11_17475 ENOG4105DU1 integral membrane protein, terc HLY11_17480 ENOG4105EE0 oxidoreductase HLY11_17485 ENOG4108UB4 uncharacterized protein ygjQ HLY11_17490 ENOG4108VKG metal-dependent hydrolase HLY11_17505 ENOG4108Z3N Transcriptional regulator HLY11_17510 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HLY11_17515 ENOG4107WCA isomerase HLY11_17520 ENOG4107W6W Conserved Protein HLY11_17525 ENOG4105E5D amino acid HLY11_17530 ENOG4105FK9 beta-D-galactosidase beta subunit HLY11_17535 ENOG4105CNT hydrolase family 2 HLY11_17540 ENOG4105CQ4 Transcriptional regulator HLY11_17545 ENOG4108Y51 tRNA-binding protein HLY11_17555 ENOG4107RHT methyl-accepting chemotaxis sensory transducer with Pas Pac sensor HLY11_17560 ENOG4105NTW Transcriptional regulator HLY11_17565 ENOG4105Q26 Siderophore-interacting protein HLY11_17580 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HLY11_17585 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) HLY11_17595 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) HLY11_17600 ENOG4107QPK )-transporter HLY11_17605 ENOG4107GFK fumarate HLY11_17610 ENOG4106DSS Tartrate dehydratase subunit alpha HLY11_17615 ENOG4105EJC lysr family transcriptional regulator HLY11_17625 ENOG4107ZVW dihydroneopterin aldolase HLY11_17640 ENOG4106MWK domain protein HLY11_17645 ENOG4105I7R Adenylate cyclase HLY11_17670 ENOG4107S78 Band 7 protein HLY11_17675 ENOG4105PV3 Inner membrane protein yqiJ HLY11_17685 ENOG4105W0Z cytoplasmic protein HLY11_17705 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b HLY11_17710 ENOG4106032 Glutathionylspermidine synthase HLY11_17720 ENOG4105DFG type I secretion outer membrane protein HLY11_17725 ENOG41087AY ADP-Ribose pyrophosphatase HLY11_17730 ENOG4108SX3 cytoplasmic protein HLY11_17735 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) HLY11_17740 ENOG4105IPS esterase HLY11_17745 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HLY11_17765 ENOG4108RVA ribokinase HLY11_17785 ENOG4105CT4 transporter HLY11_17790 ENOG4105VRH Antibiotic biosynthesis monooxygenase HLY11_17795 ENOG4105NF4 modulator of drug activity HLY11_17800 ENOG4105DHQ Histidine kinase HLY11_17805 ENOG4105XJC Two component transcriptional regulator (Winged helix family HLY11_17810 ENOG4105H4F exported protein HLY11_17815 ENOG4105F4I Transcriptional regulator HLY11_17820 ENOG4105RT5 Toxic component of a toxin-antitoxin (TA) module. An mRNA interferase which has been reported to be translation- independent (PubMed 19690171, PubMed 19943910) and translation- dependent (PubMed 20041169). Cleavage has been reported to occur on either side of G in the sequence GCU (PubMed 19690171) but also after C in GC(A U) sequences (PubMed 19943910). There are only 14 genes in E.coli W3110 (and probably also MG1655) that do not have a GCU sequence and thus are resistant to the mRNA interferase activity. Overexpression causes cessation of cell growth and inhibits cell proliferation via inhibition of translation as well as increasing persister cell formation HLY11_17825 ENOG4105WJ3 XRE family Transcriptional regulator HLY11_17830 ENOG4108J59 Extracellular solute-binding protein, family 5 HLY11_17835 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HLY11_17840 ENOG4107S7E 1-acyl-sn-glycerol-3-phosphate acyltransferase HLY11_17845 ENOG4107TZ2 Cell division protein that is required for growth during stress conditions. May be involved in protecting or stabilizing the divisomal assembly under conditions of stress (By similarity) HLY11_17860 ENOG4105CCT upf0313 protein HLY11_17880 ENOG4105ZKC Conserved Protein HLY11_17885 ENOG4105CV8 reductase HLY11_17890 ENOG4108I6A alcohol dehydrogenase HLY11_17895 ENOG4105CF7 AraC family transcriptional regulator HLY11_17900 ENOG4108K81 inner membrane protein YghB HLY11_17905 ENOG4105C28 cystathionine HLY11_17910 ENOG4105CWK Biopolymer transport protein, ExbB HLY11_17915 ENOG4108ZZF transport protein (ExbD) HLY11_17920 ENOG4105CYX Short-chain dehydrogenase reductase Sdr HLY11_17930 ENOG4105CPC Aldo Keto reductase HLY11_17940 ENOG410900S Protein of unknown function (DUF2623) HLY11_17945 ENOG4105E3S small subunit HLY11_17950 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein HLY11_17955 ENOG4105CJ5 hydrogenase 2 b cytochrome subunit HLY11_17960 ENOG4105DPX Hydrogenase, large subunit HLY11_17965 ENOG4108USZ hydrogenase HLY11_17970 ENOG4108WGS hydrogenase 2-specific chaperone HLY11_17975 ENOG4105WMM Probably plays a role in a hydrogenase nickel cofactor insertion step (By similarity) HLY11_17980 ENOG41082MF Hydrogenase assembly chaperone hypC hupF HLY11_17985 ENOG4105CYM Glutathione S-transferase HLY11_17990 ENOG4106032 Glutathionylspermidine synthase HLY11_17995 ENOG4105CJ3 phosphate transporter HLY11_18000 ENOG4108GH0 ATP-binding protein yghT HLY11_18005 ENOG4108NDC ATP-binding protein yghS HLY11_18010 ENOG4106FPV ATP-binding protein YghR HLY11_18015 ENOG4108S55 polysaccharide biosynthesis protein HLY11_18025 ENOG4108UUE Transcriptional regulator HLY11_18030 ENOG4108M8S permease YjgP YjgQ family protein HLY11_18040 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) HLY11_18045 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) HLY11_18055 ENOG4107RCI amp-dependent synthetase and ligase HLY11_18065 ENOG4108KWP DNA-binding transcriptional regulator GlcC HLY11_18070 ENOG4105CQB FAD linked oxidase domain protein HLY11_18075 ENOG4105EU8 FAD linked oxidase domain protein HLY11_18080 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) HLY11_18085 ENOG4108ZJF Glcg protein HLY11_18090 ENOG4107QP3 malate synthase g HLY11_18095 ENOG4105DAA L-lactate HLY11_18125 ENOG4108UQV Membrane HLY11_18130 ENOG4105CXN decarboxylase HLY11_18135 ENOG4105EAA nucleoside HLY11_18150 ENOG4105CEN a g-specific adenine glycosylase HLY11_18160 ENOG41090ED Protein with unknown function (DUF469) HLY11_18165 ENOG4105K33 Periplasmic Protein HLY11_18170 ENOG4105HDK L-asparaginase HLY11_18175 ENOG4106MH3 alpha helix chain HLY11_18180 ENOG4105CSA Coproporphyrinogen iii oxidase HLY11_18185 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) HLY11_18195 ENOG4108VIA integral membrane protein HLY11_18200 ENOG4105DFA alanine racemase domain protein HLY11_18205 ENOG4105CZX twitching motility protein HLY11_18220 ENOG4105D7Z glutathione synthase HLY11_18225 ENOG4105QF0 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) HLY11_18230 ENOG4105RWS endonuclease I HLY11_18240 ENOG4107QNK )-transporter HLY11_18260 ENOG4105DP5 Catalyzes the biosynthesis of agmatine from arginine (By similarity) HLY11_18280 ENOG4108K0D peptidase, M48 HLY11_18285 ENOG4105CV1 Transketolase (EC 2.2.1.1) HLY11_18290 ENOG4105EPW hflc protein HLY11_18295 ENOG4108X7Y Mannitol-specific cryptic phosphotransferase enzyme iia HLY11_18300 ENOG4105CTS PTS system mannitol-specific HLY11_18305 ENOG4105DXH Alcohol dehydrogenase zinc-binding domain protein HLY11_18310 ENOG4108Q8A Fructose-1,6-bisphosphatase HLY11_18315 ENOG4108R4K DNA-binding, transcriptional regulator HLY11_18320 ENOG4107Z1W Fructose transport system kinase HLY11_18325 ENOG4108JJB ABC transporter HLY11_18330 ENOG4108JJB ABC transporter HLY11_18360 ENOG4105D2N Aldolase HLY11_18365 ENOG4105D64 Mechanosensitive ion channel HLY11_18370 ENOG4108ZUB Lysine exporter protein (Lyse ygga) HLY11_18375 ENOG4105MPN Membrane HLY11_18380 ENOG4105DEQ transcriptional regulator HLY11_18385 ENOG4105CYC Transferase HLY11_18390 ENOG4108M7F enoyl-CoA hydratase isomerase HLY11_18395 ENOG4105DJT lAO AO transport system ATPase HLY11_18400 ENOG4105D5P Methylmalonyl-coA mutase HLY11_18410 ENOG4105E3J oxidoreductase HLY11_18415 ENOG4105RC8 Reduces the permeability of the outer membrane to copper. Seems to be involved in the regulation of biofilm formation. May decrease biofilm formation by repressing cell-cell interaction and cell surface interaction HLY11_18420 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) HLY11_18435 ENOG4108JQ1 Dehydrogenase HLY11_18450 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase HLY11_18470 ENOG4107RAQ aminopeptidase HLY11_18475 ENOG4105D0A hydroxylase HLY11_18480 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family HLY11_18505 ENOG4105CS2 ec 3.2.1.21 HLY11_18510 ENOG4105N5Z UPF0267 protein HLY11_18515 ENOG4108UT2 hemolysin iii HLY11_18525 ENOG4105Y75 tpr repeat protein HLY11_18530 ENOG4108YDB Toxic component of a toxin-antitoxin (TA) module. Overexpression leads to growth arrest after 5 hours, with initial elongation of cells, followed by swelling. The toxic effects are abrogated by coexpression with antitoxin CptB. Interacts with cytoskeletal proteins FtsZ and MreB HLY11_18535 ENOG41071R3 Low-potential electron donor to a number of redox enzymes (By similarity) HLY11_18540 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HLY11_18545 ENOG4105T95 Thiol disulfide interChange protein HLY11_18550 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) HLY11_18560 ENOG4105CRK lysyL-tRNA synthetase HLY11_18580 ENOG4105C2W permease HLY11_18585 ENOG4105BZ8 glutamate synthase HLY11_18590 ENOG4108R8B oxidoreductase Fe-S subunit HLY11_18595 ENOG4105C7N Xanthine uracil vitamin C permease HLY11_18600 ENOG4107QUY Guanine deaminase HLY11_18605 ENOG4105C2W permease HLY11_18610 ENOG4105C7W Xanthine dehydrogenase HLY11_18615 ENOG410873Y FAD binding domain in molybdopterin dehydrogenase HLY11_18620 ENOG4107UUR Chlorohydrolase aminohydrolase HLY11_18625 ENOG4105BZ8 glutamate synthase HLY11_18630 ENOG4105MFX 4-diphosphocytidyl-2c-methyl-d-erythritol synthase HLY11_18635 ENOG4105MJ6 selenium-dependent hydroxylase accessory protein YqeC HLY11_18640 ENOG4107P0T Selenium-dependent molybdenum hydroxylase system protein, YqeB family HLY11_18645 ENOG4105C5B carbamate kinase HLY11_18655 ENOG4107S4Y M20 DapE family protein YgeY HLY11_18660 ENOG4107RCH Diaminopropionate ammonia-lyase HLY11_18665 ENOG4105IW6 Carbamoyltransferase HLY11_18670 ENOG4108JUB Transcriptional regulator HLY11_18675 ENOG4108UTP (2Fe-2S)-binding domain protein HLY11_18680 ENOG4108HR6 Dehydrogenase HLY11_18685 ENOG4105C7W Xanthine dehydrogenase HLY11_18690 ENOG4108K5P (LipO)protein HLY11_18700 ENOG4108T88 HLY11_18710 ENOG41090HZ type iii secretion HLY11_18720 ENOG4108N8R Invasion protein HLY11_18725 ENOG4108HR8 type iii secretion HLY11_18730 ENOG4108JIR Flagellum-specific ATP synthase HLY11_18750 ENOG41075IY surface presentation of antigens protein SpaP HLY11_18755 ENOG4105U07 type iii secretion HLY11_18760 ENOG4108TN6 type iii secretion HLY11_18765 ENOG4108M6W surface presentation of antigens protein SpaS HLY11_18780 ENOG4108RC9 Type III secretion system protein HLY11_18785 ENOG4105Y7Q type iii secretion HLY11_18790 ENOG4106BTR HLY11_18795 ENOG4108RBT type iii secretion HLY11_18820 ENOG4105K5T PilT protein HLY11_18830 ENOG4108YAB Invasion protein HLY11_18855 ENOG4105FV3 HLY11_18860 ENOG4108TC1 Transcriptional regulator HLY11_18865 ENOG4105ISV protein with bipartite regulator domain HLY11_18870 ENOG4108MHD transport protein HLY11_18875 ENOG4105CHU acetyl-coa acetyltransferase HLY11_18885 ENOG4105CHR reductase HLY11_18890 ENOG4107QNK )-transporter HLY11_18900 ENOG4105RQF LysR family Transcriptional regulator HLY11_18910 ENOG41060NJ transcriptional regulator HLY11_18925 ENOG4105CPC Aldo Keto reductase HLY11_18930 ENOG4105SUV lipoprotein YgdR HLY11_18935 ENOG4105EE5 Membrane protein terC HLY11_18950 ENOG4108HRM phosphoenolpyruvate--protein phosphotransferase HLY11_18965 ENOG4105IPU prepilin peptidase dependent protein A HLY11_18970 ENOG4105JCS prepilin peptidase dependent protein HLY11_18975 ENOG4105SEN Protein of unknown function (DUF2509) HLY11_18980 ENOG4105RVB Prepilin peptidase dependent protein c HLY11_18985 ENOG4105DSY exodeoxyribonuclease V, gamma HLY11_18990 ENOG4107QXK peptidase HLY11_18995 ENOG4107QKA exodeoxyribonuclease V beta HLY11_19000 ENOG4107QYX exodeoxyribonuclease v alpha HLY11_19005 ENOG4108EKC n-acetylglutamate synthase HLY11_19010 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase HLY11_19015 ENOG4105CID antiterminator HLY11_19020 ENOG4105CI1 PTS System HLY11_19025 ENOG4105C87 Aminotransferase class I and II HLY11_19030 ENOG4105C2X Arabinose 5-phosphate isomerase HLY11_19045 ENOG4105CA3 membrane-bound lytic murein transglycosylase HLY11_19050 ENOG4105CUZ uba thif-type nad fad binding protein HLY11_19055 ENOG4105P9C Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity) HLY11_19060 ENOG4105C9B Cysteine desulfurase HLY11_19065 ENOG4105M5B (LipO)protein HLY11_19070 ENOG4105ETT transcriptional Regulator, LysR family HLY11_19075 ENOG4105M08 Membrane HLY11_19085 ENOG4107EDW L-fucose operon activator HLY11_19095 ENOG4105CMG Carbohydrate kinase HLY11_19100 ENOG4105EHF Converts the aldose L-fucose into the corresponding ketose L-fuculose (By similarity) HLY11_19105 ENOG4105EDR glucose galactose transporter HLY11_19110 ENOG4107W7X Aldolase HLY11_19115 ENOG4105C0A alcohol dehydrogenase HLY11_19125 ENOG4105EJQ L-serine dehydratase HLY11_19130 ENOG4105C44 Serine transporter HLY11_19135 ENOG4105EWT decarboxylase family HLY11_19150 ENOG4105WP7 tRNA pseudouridine synthase C HLY11_19155 ENOG4105DR9 pseudouridine synthase HLY11_19160 ENOG4105QDK Flavodoxin HLY11_19165 ENOG4105DJB Major Facilitator Superfamily HLY11_19170 ENOG4105EQX glucarate dehydratase HLY11_19175 ENOG4105EQX glucarate dehydratase HLY11_19180 ENOG4105BZU Histidine kinase HLY11_19190 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) HLY11_19195 ENOG4105DXN mazG family HLY11_19210 ENOG4105HA9 of methanol dehydrogenase type HLY11_19220 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) HLY11_19230 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase HLY11_19250 ENOG4107635 Hok Gef family protein HLY11_19260 ENOG4108MXK alkaline phosphatase isozyme conversion HLY11_19280 ENOG4105N0Z inner membrane protein ygbE HLY11_19300 ENOG4106NZV Responsible for synthesis of pseudouridine from uracil- 13 in transfer RNAs (By similarity) HLY11_19315 ENOG4108K5P (LipO)protein HLY11_19320 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HLY11_19330 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase HLY11_19335 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) HLY11_19340 ENOG4105KZM cytoplasmic protein HLY11_19345 ENOG4105MEW serine threonine protein phosphatase HLY11_19360 ENOG4105VXR cytoplasmic protein HLY11_19365 ENOG4108JUA Transcriptional regulator HLY11_19370 ENOG4105C45 hydrogenase expression formation protein (HypE) HLY11_19375 ENOG4105CQS hydrogenase expression formation protein HypD HLY11_19380 ENOG41083WG hydrogenase assembly chaperone HLY11_19385 ENOG4107RSS Hydrogenase accessory protein HypB HLY11_19390 ENOG410816D Probably plays a role in a hydrogenase nickel cofactor insertion step (By similarity) HLY11_19395 ENOG4108VRC Formate hydrogenlyase regulatory protein hycA HLY11_19400 ENOG4108MFN small subunit of hydrogenase-3, iron-sulfur protein (part of formate hydrogenlyase (FHL) complex) HLY11_19405 ENOG4107R30 NADH dehydrogenase HLY11_19410 ENOG4107TDF Formate hydrogenlyase subunit 4 HLY11_19415 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HLY11_19420 ENOG4108RG7 formate hydrogenlyase complex iron-sulfur subunit HLY11_19425 ENOG4105C47 NADH ubiquinone oxidoreductase 20 kda subunit HLY11_19430 ENOG4105I6X formate hydrogenlyase maturation HLY11_19435 ENOG4108MG9 hydrogenase 3 maturation protease HLY11_19440 ENOG4105CS2 ec 3.2.1.21 HLY11_19445 ENOG4105C5Y PTS System HLY11_19450 ENOG4105DDV Transcriptional regulator (LacI family HLY11_19455 ENOG4108RC0 Electron transport protein HLY11_19460 ENOG4105C8H hydrogenase maturation protein Hypf HLY11_19485 ENOG410804X Transcriptional regulator HLY11_19490 ENOG4105J92 DNA-binding transcriptional activator GutM HLY11_19495 ENOG4107QMF Sorbitol-6-phosphate dehydrogenase HLY11_19500 ENOG4105VI0 Pts system, glucitol sorbitol-specific HLY11_19505 ENOG4105DZY Pts system, glucitol sorbitol-specific HLY11_19510 ENOG410787A Pts system, glucitol sorbitol-specific HLY11_19515 ENOG4105CVE Lytic murein transglycosylase HLY11_19525 ENOG4107TH8 cina domain protein HLY11_19545 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) HLY11_19575 ENOG4107VXZ Hydrolase HLY11_19580 ENOG4105W39 Membrane HLY11_19605 ENOG4105C0R drug resistance transporter emrb qaca subfamily HLY11_19610 ENOG4105CW7 secretion protein, HlyD family HLY11_19615 ENOG4105NTK Transcriptional repressor Mpra HLY11_19625 ENOG4105ZED uncharacterized protein ygaH HLY11_19630 ENOG4108UMN azlc family HLY11_19640 ENOG4105GIJ Glycine betaine HLY11_19645 ENOG4108HQS Glycine betaine HLY11_19650 ENOG4108IJ7 Glycine betaine HLY11_19655 ENOG4107R25 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HLY11_19660 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HLY11_19670 ENOG4105WAZ (Glutaredoxin-like protein) NrdH HLY11_19675 ENOG4108ZQZ Bacterial protein of unknown function (DUF883) HLY11_19680 ENOG4108WMJ Protein of unknown function (DUF2002) HLY11_19685 ENOG4108RNS Exports L-alanine (By similarity) HLY11_19690 ENOG4108X73 DNA- binding protein HLY11_19695 ENOG4108V62 Rhodanese domain protein HLY11_19700 ENOG41080HT Transcriptional regulator, arsr family HLY11_19705 ENOG4105VPI YqaE family transport protein HLY11_19710 ENOG4109066 lysm domain bon superfamily protein HLY11_19715 ENOG4108PVQ transcriptional regulator HLY11_19720 ENOG4105C85 amino acid HLY11_19725 ENOG4108JPW Aminotransferase HLY11_19730 ENOG4105C26 Dehydrogenase HLY11_19735 ENOG4105D5U fad dependent oxidoreductase HLY11_19745 ENOG4105E54 alpha-amylase HLY11_19770 ENOG4108MGN ATP-binding component of a transport system HLY11_19785 ENOG4108Z1B Cyclase dehydrase HLY11_19795 ENOG4105YRI Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) HLY11_19800 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) HLY11_19815 ENOG4108JU6 CBS domain protein HLY11_19820 ENOG4106KVJ cytochrome C assembly protein HLY11_19825 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY HLY11_19850 ENOG41090EK ompa motb domain protein HLY11_19855 ENOG4108KHX Diguanylate cyclase HLY11_19860 ENOG4108WS1 HLY11_19865 ENOG4105QP9 Protein of unknown function (DUF2799) HLY11_19870 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) HLY11_19875 ENOG4105EHE chorismate mutase- prephenate dehydrogenase HLY11_19880 ENOG4105CQC Prephenate dehydratase HLY11_19890 ENOG4108WPH sigma 54 modulation protein ribosomal protein S30EA HLY11_19895 ENOG4106SNF Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane HLY11_19900 ENOG4105C34 Pseudouridine synthase HLY11_19905 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase HLY11_19910 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit HLY11_19935 ENOG4105CSH Transporter HLY11_19940 ENOG4105T42 (LipO)protein HLY11_19945 ENOG4105JIM Phosphatidylserine synthase HLY11_19950 ENOG4105CD5 CoA-binding domain protein HLY11_19955 ENOG4106IUH DTW domain containing protein HLY11_19960 ENOG4105K63 Thioredoxin HLY11_19965 ENOG4105EIB trna rrna methyltransferase HLY11_19985 ENOG41090KR LysR family transcriptional Regulator HLY11_19990 ENOG4105C1J atp-dependent rna helicase HLY11_20000 ENOG4108IYU L-aspartate oxidase HLY11_20010 ENOG4105EMN RNA polymerase sigma factor HLY11_20015 ENOG41069PW sigma-e factor negative regulatory protein HLY11_20020 ENOG4105VQK sigma E regulatory protein, MucB RseB HLY11_20025 ENOG4105WMJ Positive regulator of sigma E, RseC MucC HLY11_20035 ENOG4105C3F Signal peptidase i HLY11_20055 ENOG4105CSZ Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity) HLY11_20060 ENOG4105KJV Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) HLY11_20070 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding HLY11_20075 ENOG4106G6Q Transcriptional regulator HLY11_20080 ENOG4105HYY HAD superfamily (Subfamily IF) hydrolase, YfhB HLY11_20085 ENOG4108Z6B deaminase HLY11_20095 ENOG4108ETH Formylglycinamide ribotide synthetase HLY11_20100 ENOG4107WP9 Histidine kinase HLY11_20105 ENOG4108SKK alpha helix protein HLY11_20110 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family HLY11_20120 ENOG4108EGH Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) HLY11_20130 ENOG4108NZE NAGC-like transcriptional regulator HLY11_20135 ENOG4107HQ7 repeat protein HLY11_20140 ENOG4105FCA ABC transporter periplasmic-binding protein YphF HLY11_20145 ENOG4108F37 ATP-binding component of a transport system HLY11_20150 ENOG4105CNN ABC, transporter HLY11_20155 ENOG4105CPQ Dehydrogenase HLY11_20160 ENOG4108ZKT aldose 1-epimerase HLY11_20165 ENOG4108SB3 DoxX Family HLY11_20190 ENOG4105FUY alpha subunit HLY11_20195 ENOG4108W5M transcriptional regulator HLY11_20200 ENOG4105D8G Major Facilitator superfamily HLY11_20205 ENOG4108MN2 Stationary phase inducible protein CsiE HLY11_20210 ENOG4107XM9 (LipO)protein HLY11_20215 ENOG4105ECY inositol monophosphatase HLY11_20235 ENOG4107XTC May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins HLY11_20255 ENOG4108ZIT Ferredoxin, 2FE-2S HLY11_20260 ENOG4105WVQ Fe-S assembly protein IscX HLY11_20270 ENOG4105YYA enhanced serine sensitivity protein SseB HLY11_20285 ENOG4105KHC sulfurtransferase HLY11_20290 ENOG4105DN3 alpha-2-macroglobulin domain protein HLY11_20295 ENOG4108JQB penicillin-binding protein 1C HLY11_20325 ENOG4105N21 Membrane HLY11_20340 ENOG4105VPD cellular component movement HLY11_20365 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) HLY11_20375 ENOG41066DY Membrane HLY11_20380 ENOG4108ZMA Outer membrane lipoprotein HLY11_20385 ENOG41062G3 Protein of unknown function (DUF2633) HLY11_20395 ENOG4105BZU Histidine kinase HLY11_20400 ENOG4105C9X ppx gppa phosphatase HLY11_20405 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) HLY11_20410 ENOG4108V3E phosphoribosylglycinamide formyltransferase HLY11_20415 ENOG4105CXB phosphoribosylaminoimidazole synthetase HLY11_20425 ENOG4105C2W permease HLY11_20430 ENOG4108KZ1 Mediates the interaction of DNA replication inititator protein DnaA with DNA polymerase subunit beta sliding clamp (dnaN). Stimulates hydrolysis of ATP-DnaA to ADP-DnaA, rendering DnaA inactive for reinititation, a process called regulatory inhibition of DnaA or RIDA (By similarity) HLY11_20435 ENOG4105K89 arsenate reductase HLY11_20440 ENOG4105ERG peptidase m48, ste24p HLY11_20445 ENOG4105C02 permease HLY11_20450 ENOG4105TMB Formate nitrite transporter HLY11_20455 ENOG4108JUA Transcriptional regulator HLY11_20460 ENOG4105I6X formate hydrogenlyase maturation HLY11_20465 ENOG4105C47 NADH ubiquinone oxidoreductase 20 kda subunit HLY11_20475 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HLY11_20480 ENOG4108JPZ Monovalent cation H antiporter subunit D HLY11_20485 ENOG4107WQX hydrogenase 4 membrane subunit HLY11_20490 ENOG4105D65 subunit l HLY11_20495 ENOG4107TDF Formate hydrogenlyase subunit 4 HLY11_20500 ENOG4108JPZ Monovalent cation H antiporter subunit D HLY11_20505 ENOG4108MFN small subunit of hydrogenase-3, iron-sulfur protein (part of formate hydrogenlyase (FHL) complex) HLY11_20510 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen HLY11_20515 ENOG4105RH4 Glycine cleavage system transcriptional repressor HLY11_20525 ENOG4107EG0 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) HLY11_20535 ENOG4105CGZ zinc metallopeptidase HLY11_20540 ENOG4105E0I Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP) (By similarity) HLY11_20545 ENOG4106KED esterase YpfH HLY11_20560 ENOG4105KUZ arsenate reductase HLY11_20570 ENOG4105BZS acriflavin resistance protein HLY11_20575 ENOG4105BZU Histidine kinase HLY11_20580 ENOG4105BZ8 glutamate synthase HLY11_20590 ENOG4108PVD exported protein HLY11_20595 ENOG4105CV1 Transketolase (EC 2.2.1.1) HLY11_20600 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) HLY11_20605 ENOG4105C6K Malic enzyme HLY11_20610 ENOG4108VJN May be involved in the formation of a specific microcompartment in the cell in which the metabolism of potentially toxic by-products takes place HLY11_20615 ENOG4106S4J ethanolamine utilization protein EutP HLY11_20620 ENOG4105NDK ethanolamine utilization protein HLY11_20625 ENOG4108PFF ethanolamine utilization cobalamin adenosyltransferase HLY11_20630 ENOG4107WUY phosphate acetyltransferase HLY11_20635 ENOG4105KNY Microcompartments protein HLY11_20640 ENOG4105WVM ethanolamine utilization protein EutN carboxysome structural protein Ccml HLY11_20645 ENOG4108EKI Dehydrogenase HLY11_20650 ENOG4107RWI ethanolamine utilization protein eutJ HLY11_20655 ENOG4105C0A alcohol dehydrogenase HLY11_20660 ENOG4105ENY Ethanolamine utilization protein eutH HLY11_20665 ENOG4105DYY Reactivating factor for ethanolamine ammonia lyase HLY11_20670 ENOG4105CPD ethanolamine ammonia-lyase HLY11_20680 ENOG4106D67 ethanolamine utilization protein HLY11_20685 ENOG4108X49 Ethanolamine utilization protein EutK HLY11_20690 ENOG4108K3Z AraC family transcriptional regulator HLY11_20700 ENOG4108KNB n-acetylmuramoyl-l-alanine amidase HLY11_20710 ENOG4105QZU Inner membrane protein YfeZ HLY11_20715 ENOG4105E7K (LipO)protein HLY11_20720 ENOG4105EZR dyp-type peroxidase family protein HLY11_20725 ENOG4107QK9 Beta-lactamase HLY11_20730 ENOG4105C5Y PTS System HLY11_20745 ENOG4105I7Z Short-chain dehydrogenase reductase Sdr HLY11_20750 ENOG4108J2H Sulfate ABC transporter periplasmic sulfate-binding protein HLY11_20755 ENOG4108I5D sulfate abc transporter HLY11_20760 ENOG4105ECW sulfate abc transporter HLY11_20765 ENOG4108IJ6 ABC transporter HLY11_20770 ENOG4105C6T cysteine synthase HLY11_20780 ENOG4105WEC Molybdate metabolism regulator HLY11_20785 ENOG4105M0Y HLY11_20795 ENOG4105C5Y PTS System HLY11_20800 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) HLY11_20810 ENOG4105C6T cysteine synthase HLY11_20830 ENOG4105VRT cytoplasmic protein HLY11_20835 ENOG4105DHU Bile acid HLY11_20840 ENOG4105EAA nucleoside HLY11_20850 ENOG4107U5R The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity) HLY11_20855 ENOG4105EAA nucleoside HLY11_20860 ENOG4105CN8 Transcriptional regulator HLY11_20885 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) HLY11_20890 ENOG4105GXM Putative transcription regulator (DUF1323) HLY11_20895 ENOG4105HZG regulatoR HLY11_20910 ENOG4108KMM Diguanylate cyclase HLY11_20915 ENOG4105D9N nucleoside HLY11_20925 ENOG4109076 Conserved Protein HLY11_20930 ENOG4105VCT ion-transport protein YfeO HLY11_20940 ENOG4105R6B The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane (By similarity) HLY11_20945 ENOG410863U PTS System HLY11_20950 ENOG4105DC7 peptidase M24 HLY11_20955 ENOG4105CN9 Peptidase m42 family protein HLY11_20960 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) HLY11_20965 ENOG4108CIP transcriptional regulator HLY11_20970 ENOG4105DY9 regulatoR HLY11_20975 ENOG4108HRK Histidine kinase HLY11_20980 ENOG4105CHM Aminotransferase HLY11_20990 ENOG4105D1S lipid A biosynthesis HLY11_20995 ENOG4105W9M Membrane HLY11_21005 ENOG4108V08 YfdX protein HLY11_21015 ENOG4105CFN oxalyl-CoA decarboxylase HLY11_21020 ENOG4108N2Y auxin Efflux HLY11_21025 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F HLY11_21030 ENOG4105BZU Histidine kinase HLY11_21035 ENOG4108WQH regulatoR HLY11_21040 ENOG4105CW7 secretion protein, HlyD family HLY11_21045 ENOG4105C0R drug resistance transporter emrb qaca subfamily HLY11_21050 ENOG4105BZC d-serine deaminase HLY11_21060 ENOG4105W8I Transcriptional regulator HLY11_21070 ENOG4105S64 Formate nitrite transporter HLY11_21075 ENOG410903C (LipO)protein HLY11_21085 ENOG4105CKF membrane protein involved in aromatic hydrocarbon degradation HLY11_21090 ENOG4105KZW UPF0381 protein HLY11_21105 ENOG4108BY2 phosphohistidine phosphatase HLY11_21115 ENOG4106PG1 outer membrane usher protein HLY11_21120 ENOG4108FZ9 Chaperone HLY11_21125 ENOG4105NEV Fimbrial HLY11_21130 ENOG4105UGQ Fimbrial HLY11_21135 ENOG4105US4 fimbrial-like protein yfcP HLY11_21150 ENOG4105C76 Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity) HLY11_21165 ENOG4105EJ9 Membrane HLY11_21170 ENOG4108BPE -transporting atpase HLY11_21175 ENOG4105MH2 YfcL protein HLY11_21185 ENOG4105CWG Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity) HLY11_21190 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) HLY11_21195 ENOG4105F9N Major Facilitator Superfamily HLY11_21200 ENOG4106WZ1 flagella biosynthesis regulator HLY11_21210 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) HLY11_21220 ENOG4105DQR SNARE associated Golgi HLY11_21230 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase HLY11_21235 ENOG4108S3P Sporulation domain protein HLY11_21240 ENOG4105E96 Colicin v production protein HLY11_21245 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase HLY11_21250 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase HLY11_21255 ENOG4105E89 ABC transporter HLY11_21260 ENOG4105E89 ABC transporter HLY11_21265 ENOG4105DSP amino acid AbC transporter HLY11_21270 ENOG4106YG3 ABC transporter HLY11_21275 ENOG4108JEH abc transporter atp-binding protein HLY11_21280 ENOG4105DNE Transposase HLY11_21285 ENOG4105ECP epimerase HLY11_21290 ENOG4105KKP D-erythro-7,8-dihydroneopterin triphosphate 2'-epimerase HLY11_21295 ENOG4105CYM Glutathione S-transferase HLY11_21300 ENOG4108SHQ Glutathione S-transferase HLY11_21305 ENOG4108RE9 Phosphodiesterase HLY11_21310 ENOG4105PTV Nudix Hydrolase HLY11_21315 ENOG4105CSX c4-dicarboxylate anaerobic carrier HLY11_21320 ENOG4105C6K Malic enzyme HLY11_21325 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) HLY11_21335 ENOG4105XWI UPF0304 protein HLY11_21340 ENOG4105EVE HAD-superfamily hydrolase subfamily IA variant 3 HLY11_21345 ENOG4107QWE )-transporter HLY11_21355 ENOG4105CHM Aminotransferase HLY11_21360 ENOG4107NQ8 LysR family Transcriptional regulator HLY11_21375 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HLY11_21380 ENOG4105GKE subunit e HLY11_21385 ENOG4107QIZ NADH dehydrogenase HLY11_21390 ENOG4108IEH NADH dehydrogenase subunit g HLY11_21405 ENOG4107UFS subunit j HLY11_21415 ENOG4105D65 subunit l HLY11_21420 ENOG4105C8S subunit m HLY11_21430 ENOG4105GDX Domain of unknown function (DUF1877) HLY11_21435 ENOG4107VAM peptidase, m28 HLY11_21440 ENOG4105CP2 von willebrand factor, type a HLY11_21455 ENOG4107YB6 acetyltransferase, (GNAT) family HLY11_21460 ENOG4105TNS Conserved Protein HLY11_21465 ENOG4105E4F Isochorismate synthase HLY11_21480 ENOG4108IPT Naphthoate synthase HLY11_21485 ENOG4105DNI Converts SHCHC to OSB (By similarity) HLY11_21490 ENOG4105CEY Amp-dependent synthetase and ligase HLY11_21495 ENOG4106GZG polymyxin resistance protein B HLY11_21530 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase HLY11_21545 ENOG4108UII YfaZ family HLY11_21550 ENOG4108EWA cinA-like protein HLY11_21555 ENOG4107258 Transcriptional regulator HLY11_21565 ENOG4105CSP Major Facilitator Superfamily HLY11_21570 ENOG4105CNV Aldolase HLY11_21580 ENOG4105DNE Transposase HLY11_21585 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) HLY11_21595 ENOG4107R5Y anaerobic glycerol-3-phosphate dehydrogenase, subunit A HLY11_21600 ENOG4105CXY transporter HLY11_21605 ENOG4106MZZ glycerophosphoryl diester phosphodiesterase HLY11_21610 ENOG4105GZI Transcriptional regulator HLY11_21615 ENOG4105CZM Major Facilitator HLY11_21620 ENOG4105FQR PH-inducible protein involved in stress response HLY11_21625 ENOG4105XPH Ferredoxin HLY11_21630 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HLY11_21635 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HLY11_21640 ENOG4107GHC outer membrane autotransporter HLY11_21650 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HLY11_21655 ENOG4107FKF Uncharacterized protein conserved in bacteria (DUF2138) HLY11_21660 ENOG4108QJJ Protein of unknown function (DUF1175) HLY11_21665 ENOG4107S52 alpha-2-macroglobulin domain protein HLY11_21670 ENOG41081SK signal peptide protein HLY11_21675 ENOG4105EDV vault protein HLY11_21680 ENOG4105BZU Histidine kinase HLY11_21685 ENOG41068CG regulatoR HLY11_21690 ENOG4105E3G Phosphotransfer intermediate protein in two-component regulatory system with RcsBC HLY11_21695 ENOG4105FCK Membrane HLY11_21700 ENOG4105CJ2 (LipO)protein HLY11_21705 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) HLY11_21710 ENOG4105CF1 Alkylated DNA repair protein HLY11_21715 ENOG4105IBP Cyclic peptide transporter HLY11_21730 ENOG4108ZNS ferredoxin-type protein NapF HLY11_21735 ENOG41061Q0 Assembly protein for periplasmic nitrate reductase HLY11_21745 ENOG4108BGM Quinol dehydrogenase periplasmic component HLY11_21750 ENOG4105GXZ Ferredoxin-type protein NapH HLY11_21755 ENOG4108ZMS Electron transfer subunit of the periplasmic nitrate reductase complex NapAB (By similarity) HLY11_21760 ENOG4105CUW cytochrome C-TYPE protein HLY11_21765 ENOG4107EV4 once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system (By similarity) HLY11_21770 ENOG4105CA5 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes (By similarity) HLY11_21775 ENOG41060IM Heme exporter protein HLY11_21780 ENOG4105X3C heme exporter protein HLY11_21790 ENOG4105DA4 cytochrome c-type biogenesis protein HLY11_21795 ENOG4107QX9 Thiol disulfide interChange protein HLY11_21800 ENOG4105KWW Biogenesis protein HLY11_21805 ENOG4105WH1 Two component transcriptional regulator luxr family HLY11_21810 ENOG4108MGN ATP-binding component of a transport system HLY11_21820 ENOG4105E68 Sulfatase HLY11_21835 ENOG4105CUW cytochrome C-TYPE protein HLY11_21840 ENOG4107EFR Flavocytochrome c HLY11_21855 ENOG4105CFI type iii restriction protein res subunit HLY11_21860 ENOG4105I08 Pseudouridine synthase HLY11_21865 ENOG4105C2C drug resistance transporter, Bcr CflA HLY11_21870 ENOG4105HG6 HLY11_21875 ENOG4108JQ5 ABC transporter HLY11_21880 ENOG4108IYQ Binding-protein-dependent transport systems inner membrane component HLY11_21885 ENOG4108I5X binding-protein-dependent transport systems inner membrane Component HLY11_21890 ENOG4105E43 Extracellular solute-binding protein, family 5 HLY11_21895 ENOG4105CXC rtn protein HLY11_21900 ENOG4107TT5 NLP P60 protein HLY11_21905 ENOG41076MN Phosphoesterase, PA-phosphatase related HLY11_21910 ENOG4105CKI cobalamin synthesis protein HLY11_21915 ENOG4105DEI Mannitol dehydrogenase HLY11_21925 ENOG4105KRS Proteinase inhibitor HLY11_21930 ENOG4105S8Q sugar efflux transporter HLY11_21935 ENOG4105DTZ bifunctional PTS system fructose-specific transporter subunit IIA HPr protein HLY11_21940 ENOG4105DE4 1-phosphofructokinase HLY11_21945 ENOG4105DM4 PTS System HLY11_21950 ENOG4105DD7 kinase (PfkB family HLY11_21955 ENOG4105D53 Catalyzes the hydrolysis of pseudouridine 5'-phosphate (PsiMP) to ribose 5-phosphate and uracil (By similarity) HLY11_21960 ENOG4105D9N nucleoside HLY11_21965 ENOG4108Y4K DNA-binding transcriptional activator HLY11_21975 ENOG4105D9N nucleoside HLY11_21980 ENOG4105DD7 kinase (PfkB family HLY11_21990 ENOG4105HMI Membrane HLY11_21995 ENOG4105DUM transcriptional regulator, lysR family HLY11_22000 ENOG4108IQI permease HLY11_22005 ENOG4105D05 Receptor HLY11_22010 ENOG4105CXY transporter HLY11_22015 ENOG4105EAC phosphoserine phosphatase HLY11_22020 ENOG4105EJQ L-serine dehydratase HLY11_22040 ENOG4105DHF Membrane HLY11_22045 ENOG41060NJ transcriptional regulator HLY11_22050 ENOG4105EMA Periplasmic binding protein LacI transcriptional regulator HLY11_22055 ENOG4105C2J ABC transporter HLY11_22060 ENOG4108HWV )-transporter HLY11_22065 ENOG4107SJI Dehydrogenase HLY11_22070 ENOG4105BZ8 glutamate synthase HLY11_22075 ENOG4105Y9N Membrane HLY11_22080 ENOG4107GZ4 SanA protein HLY11_22090 ENOG41067MG lrgb family HLY11_22100 ENOG4105FBT Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity) HLY11_22110 ENOG4105ETP RND efflux system, outer membrane lipoprotein HLY11_22115 ENOG4105H9W Short-chain dehydrogenase reductase Sdr HLY11_22120 ENOG4105KHU inner membrane protein YohD HLY11_22125 ENOG41069YE inner membrane protein yohC HLY11_22130 ENOG41061WM D-Alanyl-D-Alanine HLY11_22135 ENOG4105CXG d-lactate dehydrogenase HLY11_22140 ENOG4107QK4 glycoside hydrolase, family 3 domain protein HLY11_22145 ENOG4107SI7 Substrate-binding region of abc-type glycine betaine transport system HLY11_22150 ENOG4107T5X Binding-protein-dependent transport systems, inner membrane component HLY11_22155 ENOG4108IJ8 ABC transporter HLY11_22160 ENOG4105WJV Binding-protein-dependent transport systems, inner membrane component HLY11_22170 ENOG4108XDN Transcriptional regulator HLY11_22175 ENOG4108HRK Histidine kinase HLY11_22180 ENOG4108NEV two component transcriptional regulator, LytTR family HLY11_22185 ENOG4108W15 Protein of unknown function (DUF1456) HLY11_22190 ENOG4108YCW (LipO)protein HLY11_22195 ENOG410903U zinc ion binding HLY11_22200 ENOG4105DEG Vwa containing coxe family protein HLY11_22205 ENOG4105RD5 HLY11_22210 ENOG4105KKX ATPase associated with various cellular activities aaa_5 HLY11_22220 ENOG4108KDT Molybdate metabolism regulator HLY11_22225 ENOG4108KDT Molybdate metabolism regulator HLY11_22230 ENOG4108KDT Molybdate metabolism regulator HLY11_22235 ENOG4108KDT Molybdate metabolism regulator HLY11_22240 ENOG4108KDT Molybdate metabolism regulator HLY11_22250 ENOG4105D1F ATP-binding protein HLY11_22255 ENOG41067AK Protein of unknown function (DUF2574) HLY11_22260 ENOG41063W2 Fimbrial protein HLY11_22265 ENOG4108MQF Chaperone HLY11_22270 ENOG4105CW0 outer membrane usher protein HLY11_22275 ENOG410662B Type-1 fimbrial protein HLY11_22280 ENOG4108Z1S Influences nickel and cobalt homeostasis. May act by modulating RcnA-mediated export of these ions to avoid excess efflux. Not involved in nickel import and does not bind nickel or cobalt ions directly HLY11_22285 ENOG41061MD high-affinity nickel-transporter HLY11_22300 ENOG4105DWF phosphomethylpyrimidine kinase HLY11_22305 ENOG4108UQ1 hydrolase, family 25 HLY11_22310 ENOG4105FDP GntR family transcriptional regulator HLY11_22315 ENOG4108TFM Kinase, PfkB family HLY11_22320 ENOG4108KD5 ADP-ribosylation crystallin J1 HLY11_22325 ENOG4105EAA nucleoside HLY11_22330 ENOG4105EIE fructose-bisphosphate aldolase HLY11_22335 ENOG4105IE8 Alpha-ketoglutarate permease HLY11_22340 ENOG4105EF1 ribulokinase HLY11_22360 ENOG4105DEI Mannitol dehydrogenase HLY11_22365 ENOG4105CMG Carbohydrate kinase HLY11_22370 ENOG4105IE8 Alpha-ketoglutarate permease HLY11_22375 ENOG4107UW8 HAD-superfamily hydrolase subfamily IA variant 3 HLY11_22385 ENOG41076Z6 Uncharacterized protein yegR HLY11_22390 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)