locus-tag	class	description
HLY11_00020	COG4695	Portal protein
HLY11_00115	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
HLY11_00130	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HLY11_00185	COG3609	addiction module antidote protein, CC2985 family
HLY11_00195	COG0745	RESPONSE REGULATOR receiver
HLY11_00200	COG2205	protein histidine kinase activity
HLY11_00240	COG4245	von Willebrand factor, type A
HLY11_00245	COG0631	protein serine/threonine phosphatase activity
HLY11_00250	COG3779	Protein conserved in bacteria
HLY11_00255	COG4248	protein with protein kinase and helix-hairpin-helix DNA-binding domains
HLY11_00260	COG0443	Heat shock 70 kDa protein
HLY11_00265	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
HLY11_00270	COG5002	protein histidine kinase activity
HLY11_00270	COG5001	Diguanylate cyclase
HLY11_00270	COG3447	MASE1 domain protein
HLY11_00275	COG0572	uridine kinase
HLY11_00285	COG2982	Protein involved in outer membrane biogenesis
HLY11_00290	COG1253	flavin adenine dinucleotide binding
HLY11_00300	COG1596	polysaccharide export
HLY11_00305	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HLY11_00310	COG0489	protein tyrosine kinase activity
HLY11_00310	COG3206	protein involved in exopolysaccharide biosynthesis
HLY11_00315	COG0463	Glycosyl transferase, family 2
HLY11_00320	COG1045	serine acetyltransferase
HLY11_00325	COG0438	transferase activity, transferring glycosyl groups
HLY11_00335	COG1216	Glycosyl transferase, family 2
HLY11_00340	COG0110	maltose O-acetyltransferase activity
HLY11_00345	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
HLY11_00350	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HLY11_00355	COG1051	belongs to the nudix hydrolase family
HLY11_00360	COG0297	glycogen (starch) synthase activity
HLY11_00365	COG0662	Cupin 2, conserved barrel domain protein
HLY11_00365	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
HLY11_00370	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HLY11_00375	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HLY11_00380	COG2244	polysaccharide biosynthetic process
HLY11_00385	COG2327	Polysaccharide pyruvyl transferase
HLY11_00390	COG0438	transferase activity, transferring glycosyl groups
HLY11_00400	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HLY11_00410	COG0438	transferase activity, transferring glycosyl groups
HLY11_00430	COG1086	Polysaccharide biosynthesis protein
HLY11_00450	COG0438	transferase activity, transferring glycosyl groups
HLY11_00455	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
HLY11_00460	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
HLY11_00485	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HLY11_00490	COG0131	Imidazoleglycerol-phosphate dehydratase
HLY11_00490	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HLY11_00500	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HLY11_00515	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HLY11_00520	COG0583	DNA-binding transcription factor activity
HLY11_00530	COG0531	amino acid
HLY11_00535	COG2925	Exonuclease
HLY11_00540	COG1686	Belongs to the peptidase S11 family
HLY11_00550	COG1289	transmembrane transporter activity
HLY11_00575	COG4656	Part of a membrane complex involved in electron transport
HLY11_00580	COG1012	belongs to the aldehyde dehydrogenase family
HLY11_00580	COG1454	alcohol dehydrogenase
HLY11_00585	COG1012	belongs to the aldehyde dehydrogenase family
HLY11_00670	COG2087	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate
HLY11_00685	COG1376	ErfK ybiS ycfS ynhG family protein
HLY11_00695	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HLY11_00700	COG3414	Phosphotransferase system galactitol-specific IIB component
HLY11_00705	COG3775	system Galactitol-specific IIC component
HLY11_00710	COG0698	ribose 5-phosphate isomerase
HLY11_00715	COG1349	DNA-binding transcription factor activity
HLY11_00725	COG3414	Phosphotransferase system galactitol-specific IIB component
HLY11_00730	COG3775	system Galactitol-specific IIC component
HLY11_00735	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HLY11_00740	COG1028	Short-chain dehydrogenase reductase Sdr
HLY11_00745	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HLY11_00755	COG0583	DNA-binding transcription factor activity
HLY11_00760	COG0583	DNA-binding transcription factor activity
HLY11_00770	COG0534	Mate efflux family protein
HLY11_00780	COG0217	transcriptional regulatory protein
HLY11_00785	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HLY11_00790	COG0477	Major facilitator Superfamily
HLY11_00800	COG2373	Large extracellular alpha-helical protein
HLY11_00800	COG4932	domain protein
HLY11_00800	COG1388	LysM domain
HLY11_00820	COG3038	cytochrome b561
HLY11_00825	COG3443	Belongs to the bacterial solute-binding protein 9 family
HLY11_00840	COG2351	hydroxyisourate hydrolase activity
HLY11_00845	COG0745	RESPONSE REGULATOR receiver
HLY11_00850	COG2205	protein histidine kinase activity
HLY11_00860	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HLY11_00870	COG1418	mRNA catabolic process
HLY11_00875	COG0270	DNA (cytosine-5-)-methyltransferase activity
HLY11_00880	COG3727	T/G mismatch-specific endonuclease activity
HLY11_00885	COG0697	spore germination
HLY11_00890	COG2354	Protein conserved in bacteria
HLY11_00895	COG5475	Uncharacterized small protein (DUF2158)
HLY11_00900	COG3706	GGDEF domain
HLY11_00920	COG2197	response regulator
HLY11_00925	COG1684	flagellar biosynthetic protein fliR
HLY11_00930	COG1987	bacterial-type flagellum assembly
HLY11_00935	COG1338	Plays a role in the flagellum-specific transport system
HLY11_00940	COG3190	flagellar
HLY11_00945	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HLY11_00950	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HLY11_00955	COG1580	Controls the rotational direction of flagella during chemotaxis
HLY11_00960	COG3144	bacterial-type flagellum assembly
HLY11_00965	COG2882	bacterial-type flagellum organization
HLY11_00970	COG1157	protein secretion by the type III secretion system
HLY11_00975	COG1317	bacterial-type flagellum organization
HLY11_00980	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HLY11_00985	COG1766	The M ring may be actively involved in energy transduction
HLY11_00995	COG2135	peptidase activity
HLY11_01000	COG0425	Belongs to the sulfur carrier protein TusA family
HLY11_01005	COG2391	methyltransferase activity
HLY11_01015	COG0366	Alpha amylase catalytic
HLY11_01025	COG1516	flagellar protein fliS
HLY11_01030	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
HLY11_01035	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HLY11_01040	COG1191	sigma factor activity
HLY11_01070	COG2197	response regulator
HLY11_01085	COG2197	response regulator
HLY11_01115	COG3012	SEC-C Motif Domain Protein
HLY11_01115	COG3318	Belongs to the UPF0149 family
HLY11_01120	COG0814	amino acid
HLY11_01130	COG1528	Iron-storage protein
HLY11_01150	COG1528	Iron-storage protein
HLY11_01155	COG1879	ABC-type sugar transport system periplasmic component
HLY11_01160	COG1129	ABC transporter
HLY11_01165	COG1172	Belongs to the binding-protein-dependent transport system permease family
HLY11_01170	COG1877	trehalose-phosphatase activity
HLY11_01180	COG0589	response to stress
HLY11_01195	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
HLY11_01200	COG1360	Flagellar Motor Protein
HLY11_01205	COG0643	Histidine kinase
HLY11_01205	COG2198	Histidine kinase
HLY11_01210	COG0835	chemotaxis
HLY11_01215	COG0840	transmembrane signaling receptor activity
HLY11_01220	COG0840	transmembrane signaling receptor activity
HLY11_01225	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
HLY11_01235	COG0745	RESPONSE REGULATOR receiver
HLY11_01240	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
HLY11_01250	COG0232	Belongs to the dGTPase family. Type 2 subfamily
HLY11_01255	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HLY11_01260	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HLY11_01270	COG3755	Protein conserved in bacteria
HLY11_01280	COG3102	Protein conserved in bacteria
HLY11_01290	COG3005	denitrification pathway
HLY11_01295	COG0243	molybdopterin cofactor binding
HLY11_01310	COG3788	relative of glutathione S-transferase, MAPEG superfamily
HLY11_01315	COG1801	Protein of unknown function DUF72
HLY11_01320	COG1335	isochorismatase
HLY11_01330	COG0494	nUDIX hydrolase
HLY11_01335	COG0217	transcriptional regulatory protein
HLY11_01365	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HLY11_01375	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
HLY11_01380	COG0739	heme binding
HLY11_01385	COG1560	Kdo2-lipid A biosynthetic process
HLY11_01390	COG0469	pyruvate kinase activity
HLY11_01395	COG1737	Transcriptional regulator
HLY11_01400	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HLY11_01405	COG0129	dihydroxy-acid dehydratase activity
HLY11_01410	COG0800	Aldolase
HLY11_01420	COG3141	response to X-ray
HLY11_01430	COG2979	Protein of unknown function (DUF533)
HLY11_01435	COG1770	oligopeptidase
HLY11_01440	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HLY11_01445	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HLY11_01455	COG2372	response to copper ion
HLY11_01460	COG1276	copper resistance
HLY11_01470	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HLY11_01490	COG3008	intermembrane lipid transfer
HLY11_01495	COG2995	paraquat-inducible protein a
HLY11_01500	COG1956	GAF domain-containing protein
HLY11_01510	COG0793	Belongs to the peptidase S41A family
HLY11_01520	COG2814	Major facilitator Superfamily
HLY11_01525	COG1414	Transcriptional regulator
HLY11_01555	COG2226	methyltransferase
HLY11_01570	COG3716	PTS system mannose fructose sorbose family IID component
HLY11_01575	COG3715	PTS system
HLY11_01580	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HLY11_01580	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HLY11_01585	COG1253	flavin adenine dinucleotide binding
HLY11_01590	COG2200	EAL domain
HLY11_01595	COG1760	l-serine dehydratase
HLY11_01605	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HLY11_01620	COG0251	oxidation-reduction process
HLY11_01625	COG1199	ATP-dependent helicase activity
HLY11_01630	COG1214	PFAM Peptidase M22, glycoprotease
HLY11_01635	COG3065	identical protein binding
HLY11_01640	COG0318	PFAM AMP-dependent synthetase and ligase
HLY11_01645	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
HLY11_01655	COG0473	3-isopropylmalate dehydrogenase activity
HLY11_01660	COG0583	DNA-binding transcription factor activity
HLY11_01670	COG3615	Tellurite resistance protein tehB
HLY11_01680	COG2261	transglycosylase associated protein
HLY11_01695	COG2203	Gaf domain
HLY11_01695	COG2199	diguanylate cyclase activity
HLY11_01700	COG3042	response to heat
HLY11_01705	COG3189	MarR family transcriptional regulator
HLY11_01710	COG2807	transmembrane transport
HLY11_01715	COG2207	Transcriptional regulator
HLY11_01730	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HLY11_01735	COG2199	diguanylate cyclase activity
HLY11_01740	COG2199	diguanylate cyclase activity
HLY11_01750	COG2766	serine protein kinase
HLY11_01755	COG3713	MltA-interacting MipA family protein
HLY11_01760	COG0656	L-ascorbic acid biosynthetic process
HLY11_01765	COG0676	glucose-6-phosphate 1-epimerase activity
HLY11_01770	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HLY11_01780	COG3139	Protein of unknown function (DUF1315)
HLY11_01785	COG1335	isochorismatase
HLY11_01790	COG0252	asparaginase activity
HLY11_01800	COG0616	signal peptide processing
HLY11_01805	COG0778	Nitroreductase
HLY11_01810	COG0709	Synthesizes selenophosphate from selenide and ATP
HLY11_01815	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HLY11_01825	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HLY11_01835	COG0494	nUDIX hydrolase
HLY11_01840	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HLY11_01845	COG2897	thiosulfate sulfurtransferase activity
HLY11_01850	COG4136	ATPase activity
HLY11_01855	COG4135	transport system, permease component
HLY11_01860	COG4134	Bacterial extracellular solute-binding protein
HLY11_01865	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HLY11_01870	COG0398	Pfam SNARE associated Golgi protein
HLY11_01880	COG0398	Pfam SNARE associated Golgi protein
HLY11_01885	COG0708	Exodeoxyribonuclease III
HLY11_01915	COG3678	ATP-independent chaperone mediated protein folding
HLY11_01925	COG0322	excinuclease ABC activity
HLY11_01935	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HLY11_01940	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HLY11_01945	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HLY11_01950	COG1447	Phosphotransferase system cellobiose-specific component IIA
HLY11_01955	COG2169	Transcriptional regulator
HLY11_01955	COG1917	Cupin 2, conserved barrel domain protein
HLY11_01960	COG1486	melibiose metabolic process
HLY11_01970	COG0753	catalase activity
HLY11_01990	COG1988	membrane-bound metal-dependent
HLY11_01995	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HLY11_02005	COG3001	Fructosamine kinase
HLY11_02015	COG1105	Belongs to the carbohydrate kinase PfkB family
HLY11_02020	COG3137	Salt-induced outer membrane protein
HLY11_02080	COG0386	Belongs to the glutathione peroxidase family
HLY11_02090	COG0791	NLP P60 protein
HLY11_02095	COG2200	EAL domain
HLY11_02105	COG4256	Hemin uptake protein
HLY11_02110	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HLY11_02120	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HLY11_02120	COG0574	Belongs to the PEP-utilizing enzyme family
HLY11_02125	COG0318	PFAM AMP-dependent synthetase and ligase
HLY11_02130	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
HLY11_02135	COG0644	oxidoreductase
HLY11_02140	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
HLY11_02145	COG2086	electron transfer activity
HLY11_02150	COG1917	Cupin 2, conserved barrel domain protein
HLY11_02150	COG2207	Transcriptional regulator
HLY11_02155	COG1960	acyl-CoA dehydrogenase activity
HLY11_02160	COG4670	ketone body catabolic process
HLY11_02175	COG2271	Major facilitator Superfamily
HLY11_02180	COG0738	Major facilitator superfamily
HLY11_02195	COG0628	permease
HLY11_02200	COG0277	FAD linked oxidase domain protein
HLY11_02200	COG0247	lactate metabolic process
HLY11_02205	COG2050	protein possibly involved in aromatic compounds catabolism
HLY11_02215	COG0316	Belongs to the HesB IscA family
HLY11_02220	COG0719	Fe-S assembly protein
HLY11_02225	COG0396	ATPase activity
HLY11_02230	COG0719	Fe-S assembly protein
HLY11_02245	COG1376	ErfK ybiS ycfS ynhG family protein
HLY11_02250	COG4238	major outer membrane lipoprotein
HLY11_02255	COG0469	pyruvate kinase activity
HLY11_02265	COG0437	4 iron, 4 sulfur cluster binding
HLY11_02270	COG2414	aldehyde ferredoxin oxidoreductase
HLY11_02280	COG0437	4 iron, 4 sulfur cluster binding
HLY11_02285	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
HLY11_02295	COG4529	Protein conserved in bacteria
HLY11_02315	COG3468	outer membrane autotransporter barrel domain protein
HLY11_02325	COG0307	riboflavin synthase, alpha
HLY11_02330	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HLY11_02335	COG2814	Major facilitator Superfamily
HLY11_02340	COG0583	DNA-binding transcription factor activity
HLY11_02355	COG2814	Major facilitator Superfamily
HLY11_02360	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HLY11_02365	COG0791	NLP P60 protein
HLY11_02370	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
HLY11_02375	COG1201	RNA secondary structure unwinding
HLY11_02385	COG0346	lactoylglutathione lyase activity
HLY11_02390	COG1902	pentaerythritol trinitrate reductase activity
HLY11_02395	COG1309	transcriptional regulator
HLY11_02400	COG3313	Fe-S protein
HLY11_02405	COG4989	oxidoreductase activity
HLY11_02410	COG2032	superoxide dismutase activity
HLY11_02415	COG1289	transmembrane transporter activity
HLY11_02420	COG1566	PFAM secretion protein HlyD family protein
HLY11_02435	COG3133	Outer membrane lipoprotein
HLY11_02445	COG3895	Periplasmic Protein
HLY11_02460	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
HLY11_02465	COG0625	glutathione transferase activity
HLY11_02470	COG3104	oligopeptide transport
HLY11_02475	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HLY11_02485	COG4659	FMN binding
HLY11_02525	COG0673	inositol 2-dehydrogenase activity
HLY11_02535	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HLY11_02540	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HLY11_02540	COG1263	PTS System
HLY11_02545	COG1609	Transcriptional regulator
HLY11_02550	COG1028	Short-chain dehydrogenase reductase Sdr
HLY11_02555	COG1309	transcriptional regulator
HLY11_02560	COG3250	beta-galactosidase activity
HLY11_02575	COG5339	Protein conserved in bacteria
HLY11_02580	COG1482	cell wall glycoprotein biosynthetic process
HLY11_02585	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HLY11_02585	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
HLY11_02590	COG0114	fumarate hydratase activity
HLY11_02600	COG2205	protein histidine kinase activity
HLY11_02605	COG0745	RESPONSE REGULATOR receiver
HLY11_02610	COG3136	membrane protein required for alginate biosynthesis
HLY11_02620	COG0531	amino acid
HLY11_02630	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
HLY11_02635	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
HLY11_02655	COG3591	Belongs to the peptidase S1B family
HLY11_02670	COG2814	Major facilitator Superfamily
HLY11_02675	COG0583	DNA-binding transcription factor activity
HLY11_02680	COG1940	carbohydrate kinase activity
HLY11_02685	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HLY11_02695	COG3381	protein complex oligomerization
HLY11_02700	COG3302	dmso reductase anchor subunit
HLY11_02705	COG0437	4 iron, 4 sulfur cluster binding
HLY11_02710	COG0243	molybdopterin cofactor binding
HLY11_02715	COG0243	molybdopterin cofactor binding
HLY11_02730	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HLY11_02745	COG4948	Mandelate Racemase Muconate Lactonizing
HLY11_02750	COG1063	alcohol dehydrogenase
HLY11_02755	COG0477	Major facilitator Superfamily
HLY11_02760	COG0246	Mannitol dehydrogenase
HLY11_02770	COG1802	Transcriptional regulator
HLY11_02775	COG4221	oxidoreductase activity
HLY11_02780	COG0339	signal peptide processing
HLY11_02785	COG1546	Belongs to the CinA family
HLY11_02790	COG3111	PFAM Bacterial OB fold (BOF) protein
HLY11_02795	COG3706	GGDEF domain
HLY11_02805	COG2814	Major facilitator Superfamily
HLY11_02810	COG0697	spore germination
HLY11_02820	COG4977	sequence-specific DNA binding
HLY11_02825	COG1846	Transcriptional regulator
HLY11_02845	COG0583	DNA-binding transcription factor activity
HLY11_02850	COG1012	belongs to the aldehyde dehydrogenase family
HLY11_02855	COG2066	Belongs to the glutaminase family
HLY11_02865	COG2199	diguanylate cyclase activity
HLY11_02875	COG3781	membrane
HLY11_02885	COG0675	Transposase, IS605 OrfB family
HLY11_02930	COG1070	Carbohydrate kinase
HLY11_02935	COG2911	Protein conserved in bacteria
HLY11_02935	COG3210	domain, Protein
HLY11_02940	COG1396	sequence-specific DNA binding
HLY11_02945	COG3550	peptidyl-serine autophosphorylation
HLY11_02975	COG1609	Transcriptional regulator
HLY11_02985	COG1053	succinate dehydrogenase
HLY11_03005	COG3539	Fimbrial protein
HLY11_03015	COG3188	usher protein
HLY11_03020	COG3539	Fimbrial protein
HLY11_03025	COG3539	Fimbrial protein
HLY11_03030	COG3539	Fimbrial protein
HLY11_03035	COG0243	molybdopterin cofactor binding
HLY11_03045	COG2207	Transcriptional regulator
HLY11_03050	COG3119	arylsulfatase activity
HLY11_03055	COG0641	radical SAM
HLY11_03065	COG4178	(ABC) transporter
HLY11_03070	COG4771	TonB-dependent receptor
HLY11_03075	COG0612	Peptidase, M16
HLY11_03080	COG0076	glutamate decarboxylase activity
HLY11_03085	COG0531	amino acid
HLY11_03095	COG3706	GGDEF domain
HLY11_03100	COG2200	EAL domain
HLY11_03100	COG2202	Pas domain
HLY11_03100	COG2199	diguanylate cyclase activity
HLY11_03105	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
HLY11_03110	COG0747	negative chemotaxis
HLY11_03115	COG0601	transmembrane transport
HLY11_03120	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HLY11_03125	COG0444	Belongs to the ABC transporter superfamily
HLY11_03130	COG4608	Belongs to the ABC transporter superfamily
HLY11_03135	COG1764	response to oxidative stress
HLY11_03155	COG1064	alcohol dehydrogenase
HLY11_03160	COG3093	addiction module antidote protein HigA
HLY11_03165	COG2864	formate dehydrogenase
HLY11_03170	COG0437	4 iron, 4 sulfur cluster binding
HLY11_03180	COG0697	spore germination
HLY11_03190	COG4886	Leucine-rich repeat (LRR) protein
HLY11_03195	COG4886	Leucine-rich repeat (LRR) protein
HLY11_03200	COG2223	nitrite transmembrane transporter activity
HLY11_03205	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
HLY11_03210	COG1140	nitrate reductase beta subunit
HLY11_03215	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
HLY11_03220	COG2181	nitrate reductase activity
HLY11_03225	COG0384	phenazine biosynthesis protein PhzF
HLY11_03230	COG2162	N-hydroxyarylamine O-acetyltransferase activity
HLY11_03235	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HLY11_03270	COG0625	glutathione transferase activity
HLY11_03275	COG1113	amino acid transport
HLY11_03280	COG3391	amine dehydrogenase activity
HLY11_03285	COG4772	TonB-dependent receptor
HLY11_03290	COG1802	Transcriptional regulator
HLY11_03295	COG2130	NADP-dependent
HLY11_03300	COG1247	-acetyltransferase
HLY11_03305	COG3238	Protein conserved in bacteria
HLY11_03330	COG1177	transmembrane transport
HLY11_03335	COG1176	ABC-type spermidine putrescine transport system, permease component I
HLY11_03340	COG3842	ATPase activity
HLY11_03345	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HLY11_03350	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HLY11_03355	COG1598	PFAM Uncharacterised protein family UPF0150
HLY11_03360	COG1724	mRNA binding
HLY11_03370	COG0826	peptidase U32
HLY11_03375	COG1396	sequence-specific DNA binding
HLY11_03380	COG3135	benzoate transporter
HLY11_03390	COG0500	methyltransferase
HLY11_03395	COG1275	C4-dicarboxylate transporter malic acid transport protein
HLY11_03400	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HLY11_03405	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HLY11_03410	COG2841	Protein conserved in bacteria
HLY11_03420	COG5383	Protein conserved in bacteria
HLY11_03425	COG0583	DNA-binding transcription factor activity
HLY11_03430	COG0840	transmembrane signaling receptor activity
HLY11_03445	COG3038	cytochrome b561
HLY11_03450	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HLY11_03455	COG1012	belongs to the aldehyde dehydrogenase family
HLY11_03460	COG1434	Gram-negative-bacterium-type cell wall biogenesis
HLY11_03465	COG1643	Atp-dependent helicase
HLY11_03475	COG0671	phosphoesterase, PA-phosphatase related
HLY11_03475	COG2453	phosphatase
HLY11_03480	COG2267	carboxylic ester hydrolase activity
HLY11_03485	COG4589	Belongs to the CDS family
HLY11_03490	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HLY11_03500	COG0667	Aldo Keto reductase
HLY11_03510	COG3784	Protein of unknown function (DUF1318)
HLY11_03520	COG2911	Protein conserved in bacteria
HLY11_03525	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HLY11_03530	COG3187	Heat shock protein
HLY11_03535	COG3042	response to heat
HLY11_03540	COG0674	pyruvate-flavodoxin oxidoreductase activity
HLY11_03540	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HLY11_03540	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HLY11_03540	COG1013	pyruvate-flavodoxin oxidoreductase activity
HLY11_03545	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HLY11_03550	COG0589	response to stress
HLY11_03560	COG0513	Belongs to the DEAD box helicase family
HLY11_03570	COG3706	GGDEF domain
HLY11_03575	COG2840	Smr protein MutS2
HLY11_03580	COG0583	DNA-binding transcription factor activity
HLY11_03585	COG1473	amidohydrolase
HLY11_03590	COG1473	amidohydrolase
HLY11_03595	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
HLY11_03600	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HLY11_03605	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HLY11_03610	COG0589	response to stress
HLY11_03615	COG3182	Iron-regulated membrane protein
HLY11_03620	COG0668	transmembrane transport
HLY11_03625	COG4166	transmembrane transport
HLY11_03630	COG2866	Carboxypeptidase
HLY11_03635	COG4948	Mandelate Racemase Muconate Lactonizing
HLY11_03640	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
HLY11_03650	COG3283	Transcriptional regulator of aromatic amino acids metabolism
HLY11_03660	COG3106	COG3106 Predicted ATPase
HLY11_03665	COG1609	Transcriptional regulator
HLY11_03675	COG3842	ATPase activity
HLY11_03680	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HLY11_03685	COG1554	hydrolase, family 65, central catalytic
HLY11_03690	COG0673	inositol 2-dehydrogenase activity
HLY11_03695	COG1082	Xylose isomerase domain protein TIM barrel
HLY11_03700	COG1063	alcohol dehydrogenase
HLY11_03705	COG0395	ABC-type sugar transport system, permease component
HLY11_03710	COG1175	transmembrane transport
HLY11_03715	COG1653	transport
HLY11_03720	COG0366	Alpha amylase catalytic
HLY11_03725	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HLY11_03735	COG1983	PspC domain protein
HLY11_03745	COG1842	Phage shock protein A
HLY11_03750	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
HLY11_03755	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HLY11_03760	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HLY11_03765	COG1012	belongs to the aldehyde dehydrogenase family
HLY11_03770	COG1396	sequence-specific DNA binding
HLY11_03770	COG1917	Cupin 2, conserved barrel domain protein
HLY11_03775	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
HLY11_03780	COG0174	glutamine synthetase
HLY11_03790	COG0531	amino acid
HLY11_03800	COG4166	transmembrane transport
HLY11_03805	COG4168	peptide transport system, permease
HLY11_03810	COG4171	peptide transport system, permease
HLY11_03815	COG4172	Belongs to the ABC transporter superfamily
HLY11_03820	COG4172	Belongs to the ABC transporter superfamily
HLY11_03825	COG2852	Protein conserved in bacteria
HLY11_03830	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HLY11_03835	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HLY11_03835	COG4950	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HLY11_03850	COG5001	Diguanylate cyclase
HLY11_03860	COG1349	DNA-binding transcription factor activity
HLY11_03870	COG0023	Translation Initiation Factor
HLY11_03880	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
HLY11_03885	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
HLY11_03890	COG0671	phosphoesterase, PA-phosphatase related
HLY11_03900	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HLY11_03920	COG0583	DNA-binding transcription factor activity
HLY11_03925	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HLY11_03935	COG0616	signal peptide processing
HLY11_03940	COG1028	Short-chain dehydrogenase reductase Sdr
HLY11_03945	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
HLY11_03950	COG1187	pseudouridine synthase activity
HLY11_03955	COG0009	L-threonylcarbamoyladenylate synthase
HLY11_03960	COG0613	PHP domain protein
HLY11_03970	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HLY11_03975	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HLY11_03975	COG0512	Glutamine amidotransferase of anthranilate synthase
HLY11_03980	COG0135	phosphoribosylanthranilate isomerase activity
HLY11_03980	COG0134	indole-3-glycerol-phosphate synthase activity
HLY11_03995	COG3729	General stress protein
HLY11_04000	COG3685	Protein conserved in bacteria
HLY11_04005	COG3685	Protein conserved in bacteria
HLY11_04010	COG3047	cAMP biosynthetic process
HLY11_04030	COG1607	acyl-coa hydrolase
HLY11_04035	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
HLY11_04040	COG2350	Protein conserved in bacteria
HLY11_04045	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HLY11_04065	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HLY11_04070	COG4608	Belongs to the ABC transporter superfamily
HLY11_04075	COG0444	Belongs to the ABC transporter superfamily
HLY11_04080	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HLY11_04085	COG0601	transmembrane transport
HLY11_04090	COG4166	transmembrane transport
HLY11_04100	COG2095	MarC family integral membrane protein
HLY11_04105	COG1012	belongs to the aldehyde dehydrogenase family
HLY11_04105	COG1454	alcohol dehydrogenase
HLY11_04115	COG1435	thymidine kinase activity
HLY11_04125	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HLY11_04130	COG0745	RESPONSE REGULATOR receiver
HLY11_04135	COG1752	Esterase of the alpha-beta hydrolase superfamily
HLY11_04145	COG0788	formyltetrahydrofolate deformylase activity
HLY11_04160	COG2181	nitrate reductase activity
HLY11_04165	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
HLY11_04170	COG1140	nitrate reductase beta subunit
HLY11_04175	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
HLY11_04180	COG2223	nitrite transmembrane transporter activity
HLY11_04185	COG3850	Histidine kinase
HLY11_04190	COG2197	response regulator
HLY11_04195	COG4932	domain protein
HLY11_04200	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
HLY11_04205	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
HLY11_04210	COG4572	Cation transport regulator
HLY11_04215	COG0387	Pfam Sodium calcium exchanger
HLY11_04230	COG2912	Transglutaminase-like superfamily
HLY11_04235	COG3094	Invasion gene expression up-regulator, SirB
HLY11_04240	COG2890	protein-(glutamine-N5) methyltransferase activity
HLY11_04265	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HLY11_04270	COG0659	secondary active sulfate transmembrane transporter activity
HLY11_04285	COG0012	GTP binding
HLY11_04290	COG3468	outer membrane autotransporter barrel domain protein
HLY11_04300	COG3284	Transcriptional regulator
HLY11_04305	COG2376	Dihydroxyacetone kinase
HLY11_04310	COG1461	Dihydroxyacetone kinase
HLY11_04315	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HLY11_04315	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HLY11_04315	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
HLY11_04335	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
HLY11_04345	COG1619	proteins homologs of microcin C7 resistance protein MccF
HLY11_04365	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HLY11_04375	COG2719	SpoVR family
HLY11_04390	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
HLY11_04395	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HLY11_04400	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HLY11_04415	COG0179	Fumarylacetoacetate (FAA) hydrolase
HLY11_04440	COG2894	cell division
HLY11_04485	COG2200	EAL domain
HLY11_04510	COG2200	EAL domain
HLY11_04515	COG0789	Transcriptional regulator
HLY11_04520	COG5562	phage envelope protein
HLY11_04535	COG0538	isocitrate dehydrogenase activity
HLY11_04550	COG1187	pseudouridine synthase activity
HLY11_04570	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HLY11_04580	COG2205	protein histidine kinase activity
HLY11_04585	COG2850	peptidyl-arginine hydroxylation
HLY11_04595	COG3842	ATPase activity
HLY11_04605	COG1177	transmembrane transport
HLY11_04610	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HLY11_04615	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HLY11_04625	COG4591	ABC-type transport system involved in lipoprotein release permease component
HLY11_04635	COG4591	ABC-type transport system involved in lipoprotein release permease component
HLY11_04640	COG4763	Acyl-transferase
HLY11_04645	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HLY11_04650	COG1376	ErfK ybiS ycfS ynhG family protein
HLY11_04650	COG1388	LysM domain
HLY11_04660	COG1309	transcriptional regulator
HLY11_04665	COG3134	Outer membrane lipoprotein
HLY11_04670	COG1252	NADH dehydrogenase
HLY11_04685	COG0510	thiamine kinase activity
HLY11_04690	COG3417	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)
HLY11_04695	COG5633	Lipoprotein
HLY11_04700	COG0537	adenosine 5'-monophosphoramidase activity
HLY11_04705	COG4773	Receptor
HLY11_04710	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HLY11_04710	COG1263	PTS System
HLY11_04715	COG0084	hydrolase, TatD family'
HLY11_04720	COG0470	DNA polymerase III
HLY11_04730	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HLY11_04735	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HLY11_04740	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HLY11_04750	COG1028	Short-chain dehydrogenase reductase Sdr
HLY11_04755	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HLY11_04775	COG1399	metal-binding, possibly nucleic acid-binding protein
HLY11_04780	COG0424	maF-like protein
HLY11_04785	COG0564	pseudouridine synthase activity
HLY11_04790	COG1530	ribonuclease E activity
HLY11_04805	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HLY11_04810	COG1256	bacterial-type flagellum assembly
HLY11_04815	COG3951	Flagellar rod assembly protein muramidase FlgJ
HLY11_04815	COG1705	Flagellar rod assembly protein muramidase FlgJ
HLY11_04830	COG4786	Flagellar basal body rod
HLY11_04835	COG4787	bacterial-type flagellum-dependent cell motility
HLY11_04840	COG1749	Flagellar hook protein flgE
HLY11_04845	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
HLY11_04850	COG1558	bacterial-type flagellum-dependent cell motility
HLY11_04855	COG1815	bacterial-type flagellum-dependent cell motility
HLY11_04860	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
HLY11_04865	COG2747	anti-sigma28 factor FlgM
HLY11_04870	COG3418	PFAM FlgN family protein
HLY11_04875	COG0728	peptidoglycan biosynthetic process
HLY11_04880	COG0673	inositol 2-dehydrogenase activity
HLY11_04890	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HLY11_04900	COG2999	glutathione oxidoreductase activity
HLY11_04935	COG3038	cytochrome b561
HLY11_04940	COG2353	YceI-like domain
HLY11_04950	COG1560	Kdo2-lipid A biosynthetic process
HLY11_04965	COG5645	(Lipo)protein
HLY11_04970	COG2943	transferase activity, transferring hexosyl groups
HLY11_04985	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HLY11_04990	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
HLY11_05015	COG2197	response regulator
HLY11_05030	COG1462	curli production assembly transport component CsgG
HLY11_05040	COG3381	protein complex oligomerization
HLY11_05085	COG2003	Belongs to the UPF0758 family
HLY11_05125	COG2378	regulation of single-species biofilm formation
HLY11_05130	COG3596	GTP binding
HLY11_05140	COG0745	RESPONSE REGULATOR receiver
HLY11_05165	COG3121	Chaperone
HLY11_05170	COG3188	usher protein
HLY11_05215	COG4983	Phage plasmid primase, P4 family domain protein
HLY11_05285	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HLY11_05290	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HLY11_05300	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HLY11_05310	COG0736	holo-[acyl-carrier-protein] synthase activity
HLY11_05315	COG2831	hemolysin activation secretion protein
HLY11_05320	COG3210	domain, Protein
HLY11_05330	COG3539	Fimbrial protein
HLY11_05340	COG3188	usher protein
HLY11_05350	COG3121	Chaperone
HLY11_05355	COG1028	Short-chain dehydrogenase reductase Sdr
HLY11_05360	COG3710	Transcriptional regulator
HLY11_05370	COG2200	EAL domain
HLY11_05375	COG3706	GGDEF domain
HLY11_05380	COG0457	Tetratricopeptide repeat
HLY11_05385	COG1649	PFAM Uncharacterised BCR, COG1649
HLY11_05385	COG0726	polysaccharide deacetylase
HLY11_05390	COG1215	transferase activity, transferring glycosyl groups
HLY11_05395	COG3658	cytochrome
HLY11_05400	COG1702	phosphate starvation-inducible protein PhoH
HLY11_05410	COG2822	iron ion transport
HLY11_05420	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HLY11_05425	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HLY11_05425	COG0506	proline dehydrogenase activity
HLY11_05425	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HLY11_05430	COG1309	transcriptional regulator
HLY11_05465	COG2233	PERMEase
HLY11_05470	COG3729	General stress protein
HLY11_05510	COG0243	molybdopterin cofactor binding
HLY11_05515	COG3005	denitrification pathway
HLY11_05520	COG0745	RESPONSE REGULATOR receiver
HLY11_05525	COG1879	ABC-type sugar transport system periplasmic component
HLY11_05530	COG2205	protein histidine kinase activity
HLY11_05530	COG2198	Histidine kinase
HLY11_05530	COG0784	Response regulator, receiver
HLY11_05535	COG0348	domain, Protein
HLY11_05555	COG1278	Cold shock
HLY11_05560	COG1278	Cold shock
HLY11_05575	COG1294	oxidase, subunit
HLY11_05580	COG1271	oxidase subunit
HLY11_05585	COG1773	rubredoxin
HLY11_05590	COG1999	signal sequence binding
HLY11_05595	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
HLY11_05600	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
HLY11_05605	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
HLY11_05610	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
HLY11_05620	COG0670	Belongs to the BI1 family
HLY11_05625	COG2920	part of a sulfur-relay system
HLY11_05630	COG1254	Belongs to the acylphosphatase family
HLY11_05645	COG1832	CoA-binding protein
HLY11_05660	COG0210	DNA helicase
HLY11_05665	COG3304	Inner membrane component domain
HLY11_05670	COG1289	transmembrane transporter activity
HLY11_05675	COG3070	regulator of competence-specific genes
HLY11_05695	COG1067	ATP-dependent peptidase activity
HLY11_05705	COG3130	regulation of translation
HLY11_05710	COG3009	Protein conserved in bacteria
HLY11_05715	COG3008	intermembrane lipid transfer
HLY11_05715	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HLY11_05720	COG2995	paraquat-inducible protein a
HLY11_05725	COG0488	(ABC) transporter
HLY11_05735	COG0633	Ferredoxin
HLY11_05735	COG3217	Mosc domain protein beta barrel domain protein
HLY11_05750	COG3121	Chaperone
HLY11_05755	COG3539	Fimbrial protein
HLY11_05760	COG3539	Fimbrial protein
HLY11_05765	COG3539	Fimbrial protein
HLY11_05770	COG3188	usher protein
HLY11_05775	COG3121	Chaperone
HLY11_05780	COG3539	Fimbrial protein
HLY11_05785	COG0431	NADPH-dependent FMN reductase
HLY11_05790	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HLY11_05800	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HLY11_05805	COG1116	anion transmembrane transporter activity
HLY11_05810	COG0308	aminopeptidase N
HLY11_05825	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HLY11_05830	COG1448	Aminotransferase
HLY11_05835	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HLY11_05840	COG3108	Peptidase M15
HLY11_05845	COG2989	Protein conserved in bacteria
HLY11_05855	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
HLY11_05865	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HLY11_05870	COG1434	Gram-negative-bacterium-type cell wall biogenesis
HLY11_05875	COG3173	Aminoglycoside phosphotransferase
HLY11_05890	COG3214	Protein conserved in bacteria
HLY11_05900	COG1132	(ABC) transporter
HLY11_05905	COG0658	competence protein
HLY11_05905	COG2333	competence protein COMEC
HLY11_05915	COG0539	negative regulation of cytoplasmic translation
HLY11_05925	COG0501	Belongs to the peptidase M48B family
HLY11_05940	COG2323	membrane
HLY11_05945	COG1944	ATP diphosphatase activity
HLY11_05950	COG2116	formate transmembrane transporter activity
HLY11_05955	COG1882	Formate acetyltransferase
HLY11_05960	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HLY11_05965	COG2249	NAD(P)H dehydrogenase (quinone) activity
HLY11_05970	COG0583	DNA-binding transcription factor activity
HLY11_05975	COG0531	amino acid
HLY11_05985	COG1335	isochorismatase
HLY11_05990	COG3302	dmso reductase anchor subunit
HLY11_05995	COG0437	4 iron, 4 sulfur cluster binding
HLY11_06000	COG0243	molybdopterin cofactor binding
HLY11_06010	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HLY11_06025	COG1522	sequence-specific DNA binding
HLY11_06030	COG0492	ferredoxin-NADP+ reductase activity
HLY11_06035	COG4988	ABC transporter
HLY11_06040	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
HLY11_06060	COG0542	response to heat
HLY11_06070	COG1278	Cold shock
HLY11_06075	COG0577	efflux transmembrane transporter activity
HLY11_06075	COG1136	(ABC) transporter
HLY11_06080	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HLY11_06085	COG2990	Protein conserved in bacteria
HLY11_06090	COG3593	DNA synthesis involved in DNA repair
HLY11_06095	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HLY11_06100	COG2431	L-lysine efflux transmembrane transporter activity
HLY11_06110	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HLY11_06115	COG0028	Belongs to the TPP enzyme family
HLY11_06120	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
HLY11_06125	COG0702	epimerase
HLY11_06130	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HLY11_06135	COG3023	N-Acetylmuramoyl-L-alanine amidase
HLY11_06155	COG1126	abc transporter atp-binding protein
HLY11_06160	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HLY11_06165	COG4215	(ABC) transporter
HLY11_06170	COG4160	amino acid transport
HLY11_06175	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HLY11_06205	COG1177	transmembrane transport
HLY11_06210	COG1176	ABC-type spermidine putrescine transport system, permease component I
HLY11_06215	COG3842	ATPase activity
HLY11_06220	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HLY11_06235	COG0778	Nitroreductase
HLY11_06245	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HLY11_06310	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
HLY11_06400	COG4695	Portal protein
HLY11_06435	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HLY11_06475	COG4973	Belongs to the 'phage' integrase family. XerC subfamily
HLY11_06480	COG3226	Transcriptional regulator
HLY11_06485	COG0738	Major facilitator superfamily
HLY11_06490	COG0561	phosphatase activity
HLY11_06500	COG2814	Major facilitator Superfamily
HLY11_06505	COG0671	phosphoesterase, PA-phosphatase related
HLY11_06510	COG1349	DNA-binding transcription factor activity
HLY11_06515	COG1686	Belongs to the peptidase S11 family
HLY11_06520	COG0625	glutathione transferase activity
HLY11_06525	COG2133	pyrroloquinoline quinone binding
HLY11_06550	COG2199	diguanylate cyclase activity
HLY11_06555	COG2200	EAL domain
HLY11_06570	COG0747	negative chemotaxis
HLY11_06580	COG1446	asparaginase
HLY11_06585	COG0303	'Molybdopterin
HLY11_06590	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HLY11_06595	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HLY11_06600	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HLY11_06605	COG1882	Formate acetyltransferase
HLY11_06610	COG0561	phosphatase activity
HLY11_06615	COG0488	(ABC) transporter
HLY11_06620	COG1376	ErfK ybiS ycfS ynhG family protein
HLY11_06625	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HLY11_06630	COG1321	iron dependent repressor
HLY11_06640	COG2194	sulfuric ester hydrolase activity
HLY11_06645	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
HLY11_06655	COG5006	permease, DMT superfamily
HLY11_06665	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HLY11_06670	COG0765	amino acid transport
HLY11_06675	COG1126	abc transporter atp-binding protein
HLY11_06680	COG0668	transmembrane transport
HLY11_06695	COG4774	siderophore transport
HLY11_06705	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HLY11_06715	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
HLY11_06720	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HLY11_06725	COG1199	ATP-dependent helicase activity
HLY11_06740	COG0513	Belongs to the DEAD box helicase family
HLY11_06745	COG1309	transcriptional regulator
HLY11_06755	COG1131	(ABC) transporter
HLY11_06760	COG0842	Transport permease protein
HLY11_06765	COG0842	Transport permease protein
HLY11_06775	COG3568	Endonuclease Exonuclease Phosphatase
HLY11_06780	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HLY11_06785	COG0392	lysyltransferase activity
HLY11_06805	COG0670	Belongs to the BI1 family
HLY11_06810	COG0670	Belongs to the BI1 family
HLY11_06820	COG0670	Belongs to the BI1 family
HLY11_06825	COG0314	molybdopterin synthase activity
HLY11_06830	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
HLY11_06840	COG0521	Mo-molybdopterin cofactor biosynthetic process
HLY11_06850	COG0391	Required for morphogenesis under gluconeogenic growth conditions
HLY11_06860	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HLY11_06865	COG2226	methyltransferase
HLY11_06880	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HLY11_06885	COG1881	PFAM PEBP family protein
HLY11_06890	COG4677	pectinesterase activity
HLY11_06895	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HLY11_06900	COG0471	metal ion transport
HLY11_06905	COG2828	Protein conserved in bacteria
HLY11_06910	COG0583	DNA-binding transcription factor activity
HLY11_06920	COG0561	phosphatase activity
HLY11_06925	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
HLY11_06930	COG4149	molybdate abc transporter
HLY11_06935	COG0725	ABC transporter, periplasmic molybdate-binding protein
HLY11_06945	COG2005	Transcriptional regulator
HLY11_06945	COG3585	molybdate ion transport
HLY11_06950	COG1119	ATPase activity
HLY11_06955	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HLY11_06960	COG1085	galactose-1-phosphate uridylyltransferase
HLY11_06970	COG2017	converts alpha-aldose to the beta-anomer
HLY11_06980	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HLY11_06990	COG1230	cation diffusion facilitator family transporter
HLY11_06995	COG3201	nicotinamide mononucleotide transporter
HLY11_07040	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
HLY11_07045	COG2885	chlorophyll binding
HLY11_07055	COG3064	Membrane
HLY11_07060	COG0848	biopolymer transport protein
HLY11_07065	COG0811	peptide transport
HLY11_07070	COG0824	Thioesterase
HLY11_07075	COG3790	cyd operon protein YbgE
HLY11_07080	COG4890	Cyd operon protein YbgT
HLY11_07085	COG1294	oxidase, subunit
HLY11_07090	COG1271	oxidase subunit
HLY11_07105	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HLY11_07115	COG4865	methylaspartate mutase activity
HLY11_07120	COG3799	methylaspartate ammonia-lyase activity
HLY11_07135	COG1301	dicarboxylic acid transport
HLY11_07140	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HLY11_07140	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
HLY11_07145	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
HLY11_07150	COG0583	DNA-binding transcription factor activity
HLY11_07160	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HLY11_07170	COG0508	dehydrogenase complex catalyzes the overall conversion of
HLY11_07175	COG0567	Dehydrogenase, E1 component
HLY11_07180	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HLY11_07185	COG1053	succinate dehydrogenase
HLY11_07190	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
HLY11_07195	COG2009	succinate dehydrogenase
HLY11_07205	COG0372	Belongs to the citrate synthase family
HLY11_07210	COG3539	Fimbrial protein
HLY11_07215	COG3188	usher protein
HLY11_07220	COG3121	Chaperone
HLY11_07225	COG3539	Fimbrial protein
HLY11_07230	COG3180	Ammonia monooxygenase
HLY11_07245	COG1984	allophanate hydrolase subunit 2
HLY11_07250	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
HLY11_07255	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HLY11_07265	COG0415	Belongs to the DNA photolyase family
HLY11_07270	COG3272	Protein of unknown function (DUF1722)
HLY11_07300	COG2205	protein histidine kinase activity
HLY11_07305	COG0745	RESPONSE REGULATOR receiver
HLY11_07320	COG0033	Phosphoglucomutase
HLY11_07325	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
HLY11_07330	COG0596	Alpha beta hydrolase
HLY11_07340	COG0716	FMN binding
HLY11_07350	COG0735	belongs to the Fur family
HLY11_07370	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HLY11_07370	COG1263	PTS System
HLY11_07370	COG2190	(PTS) system
HLY11_07380	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HLY11_07385	COG1940	carbohydrate kinase activity
HLY11_07385	COG1846	Transcriptional regulator
HLY11_07390	COG0647	UMP catabolic process
HLY11_07395	COG0367	asparagine synthase
HLY11_07435	COG3547	Transposase (IS116 IS110 IS902 family)
HLY11_07440	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HLY11_07450	COG1702	phosphate starvation-inducible protein PhoH
HLY11_07460	COG4535	Mg2 and Co2 transporter CorC
HLY11_07465	COG0815	Transfers the fatty acyl group on membrane lipoproteins
HLY11_07470	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HLY11_07475	COG0765	amino acid transport
HLY11_07480	COG0765	amino acid transport
HLY11_07485	COG1126	abc transporter atp-binding protein
HLY11_07495	COG0443	Heat shock 70 kDa protein
HLY11_07500	COG2214	Heat shock protein DnaJ domain protein
HLY11_07510	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
HLY11_07515	COG2214	Heat shock protein DnaJ domain protein
HLY11_07525	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
HLY11_07530	COG2888	peptidyl-tyrosine sulfation
HLY11_07545	COG1466	dna polymerase III delta subunit
HLY11_07555	COG0406	alpha-ribazole phosphatase activity
HLY11_07560	COG0799	negative regulation of ribosome biogenesis
HLY11_07570	COG0768	penicillin binding
HLY11_07575	COG0772	Belongs to the SEDS family
HLY11_07580	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HLY11_07585	COG1686	Belongs to the peptidase S11 family
HLY11_07600	COG0583	DNA-binding transcription factor activity
HLY11_07610	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HLY11_07615	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HLY11_07635	COG3069	C4-dicarboxylate transmembrane transporter activity
HLY11_07640	COG4565	transcriptional regulatory protein
HLY11_07645	COG3290	protein histidine kinase activity
HLY11_07650	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
HLY11_07660	COG2301	Belongs to the HpcH HpaI aldolase family
HLY11_07665	COG3051	citrate lyase alpha subunit
HLY11_07680	COG0471	metal ion transport
HLY11_07685	COG3719	Belongs to the RNase T2 family
HLY11_07690	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HLY11_07695	COG1063	alcohol dehydrogenase
HLY11_07700	COG0589	response to stress
HLY11_07705	COG3634	alkyl hydroperoxide reductase activity
HLY11_07710	COG0450	alkyl hydroperoxide reductase
HLY11_07715	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HLY11_07720	COG0583	DNA-binding transcription factor activity
HLY11_07725	COG3969	phosphoadenosine phosphosulfate
HLY11_07730	COG1475	DNA binding
HLY11_07735	COG0436	Aminotransferase
HLY11_07740	COG0371	Dehydrogenase
HLY11_07745	COG2879	small protein
HLY11_07750	COG1966	Carbon starvation protein
HLY11_07755	COG2050	protein possibly involved in aromatic compounds catabolism
HLY11_07760	COG1028	Short-chain dehydrogenase reductase Sdr
HLY11_07765	COG3433	isochorismatase activity
HLY11_07765	COG1535	isochorismatase
HLY11_07770	COG1021	2,3-dihydroxybenzoate-AMP ligase
HLY11_07775	COG1169	isochorismate synthase
HLY11_07780	COG4592	Periplasmic binding protein
HLY11_07790	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HLY11_07795	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HLY11_07800	COG1120	ATPase activity
HLY11_07805	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
HLY11_07810	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
HLY11_07810	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HLY11_07815	COG3251	PFAM MbtH domain protein
HLY11_07820	COG2382	esterase
HLY11_07825	COG4771	TonB-dependent receptor
HLY11_07830	COG2977	Belongs to the P-Pant transferase superfamily
HLY11_07860	COG2315	Protein conserved in bacteria
HLY11_07865	COG0778	Nitroreductase
HLY11_07870	COG0668	transmembrane transport
HLY11_07875	COG1113	amino acid transport
HLY11_07880	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HLY11_07885	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HLY11_07890	COG5569	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HLY11_07895	COG1538	Outer membrane efflux protein
HLY11_07900	COG0745	RESPONSE REGULATOR receiver
HLY11_07905	COG5002	protein histidine kinase activity
HLY11_07910	COG1215	transferase activity, transferring glycosyl groups
HLY11_07915	COG4783	chaperone-mediated protein folding
HLY11_07925	COG2207	Transcriptional regulator
HLY11_07935	COG2197	response regulator
HLY11_07940	COG3539	Fimbrial protein
HLY11_07945	COG3539	Fimbrial protein
HLY11_07950	COG3188	usher protein
HLY11_07955	COG3121	Chaperone
HLY11_07960	COG3539	Fimbrial protein
HLY11_07970	COG2501	S4 domain
HLY11_07975	COG1988	membrane-bound metal-dependent
HLY11_07985	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HLY11_07995	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HLY11_08000	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HLY11_08005	COG0549	Belongs to the carbamate kinase family
HLY11_08015	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HLY11_08020	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HLY11_08025	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
HLY11_08030	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HLY11_08035	COG3257	ureidoglycine aminohydrolase activity
HLY11_08040	COG1929	Belongs to the glycerate kinase type-1 family
HLY11_08045	COG2233	PERMEase
HLY11_08055	COG1953	Uracil, thiamine, allantoin
HLY11_08060	COG2084	Dehydrogenase
HLY11_08065	COG3622	Belongs to the hyi family
HLY11_08070	COG3960	tartronate-semialdehyde synthase activity
HLY11_08075	COG1414	Transcriptional regulator
HLY11_08085	COG0583	DNA-binding transcription factor activity
HLY11_08095	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
HLY11_08100	COG4181	ATPase activity
HLY11_08105	COG2755	lipolytic protein G-D-S-L family
HLY11_08110	COG0300	oxidoreductase activity
HLY11_08115	COG3118	belongs to the thioredoxin family
HLY11_08120	COG0390	transport system, permease component
HLY11_08125	COG4619	ABC transporter
HLY11_08130	COG0330	HflC and HflK could
HLY11_08135	COG1585	Membrane protein implicated in regulation of membrane protease activity
HLY11_08160	COG0789	Transcriptional regulator
HLY11_08185	COG0531	amino acid
HLY11_08195	COG2217	Heavy metal translocating P-type atpase
HLY11_08200	COG3735	TraB family
HLY11_08205	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HLY11_08210	COG0737	Belongs to the 5'-nucleotidase family
HLY11_08215	COG2223	nitrite transmembrane transporter activity
HLY11_08220	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HLY11_08220	COG4651	solute:proton antiporter activity
HLY11_08225	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HLY11_08260	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HLY11_08270	COG2832	Protein of unknown function (DUF454)
HLY11_08275	COG3923	Primosomal replication protein n
HLY11_08285	COG1196	nuclear chromosome segregation
HLY11_08285	COG3264	Mechanosensitive ion channel
HLY11_08290	COG1309	transcriptional regulator
HLY11_08295	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HLY11_08300	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HLY11_08315	COG0110	maltose O-acetyltransferase activity
HLY11_08325	COG4943	cyclic-guanylate-specific phosphodiesterase activity
HLY11_08330	COG5507	3-demethylubiquinone-9 3-methyltransferase
HLY11_08340	COG3695	enzyme binding
HLY11_08345	COG3126	Type III secretion system lipoprotein chaperone (YscW)
HLY11_08350	COG1946	Acyl-CoA thioesterase
HLY11_08355	COG0004	ammonium transporteR
HLY11_08360	COG0347	Belongs to the P(II) protein family
HLY11_08365	COG1132	(ABC) transporter
HLY11_08370	COG1132	(ABC) transporter
HLY11_08375	COG1522	sequence-specific DNA binding
HLY11_08385	COG4533	DNA binding
HLY11_08395	COG0824	Thioesterase
HLY11_08400	COG1555	photosystem II stabilization
HLY11_08405	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HLY11_08410	COG0776	regulation of translation
HLY11_08415	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HLY11_08435	COG0271	Belongs to the BolA IbaG family
HLY11_08440	COG3056	Lipoprotein
HLY11_08445	COG2223	nitrite transmembrane transporter activity
HLY11_08450	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HLY11_08455	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HLY11_08460	COG1845	cytochrome c oxidase, subunit III
HLY11_08465	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
HLY11_08490	COG2814	Major facilitator Superfamily
HLY11_08500	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HLY11_08505	COG0693	protein deglycase activity
HLY11_08520	COG0142	geranyltranstransferase activity
HLY11_08530	COG0667	Aldo Keto reductase
HLY11_08540	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HLY11_08545	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
HLY11_08560	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HLY11_08560	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HLY11_08570	COG4238	major outer membrane lipoprotein
HLY11_08575	COG3248	Nucleoside-binding outer membrane protein
HLY11_08580	COG1403	HNH endonuclease
HLY11_08590	COG3609	addiction module antidote protein, CC2985 family
HLY11_08595	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HLY11_08600	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HLY11_08605	COG1862	Preprotein translocase
HLY11_08630	COG0366	Alpha amylase catalytic
HLY11_08635	COG1113	amino acid transport
HLY11_08640	COG1114	Component of the transport system for branched-chain amino acids
HLY11_08645	COG5002	protein histidine kinase activity
HLY11_08650	COG0745	RESPONSE REGULATOR receiver
HLY11_08655	COG0420	3'-5' exonuclease activity
HLY11_08660	COG0419	ATPase involved in DNA repair
HLY11_08665	COG2814	Major facilitator Superfamily
HLY11_08670	COG1940	carbohydrate kinase activity
HLY11_08695	COG4126	flavin adenine dinucleotide binding
HLY11_08715	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HLY11_08720	COG3706	GGDEF domain
HLY11_08730	COG1785	Belongs to the alkaline phosphatase family
HLY11_08745	COG1181	Belongs to the D-alanine--D-alanine ligase family
HLY11_08765	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
HLY11_08770	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HLY11_08775	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HLY11_08780	COG3468	outer membrane autotransporter barrel domain protein
HLY11_08785	COG0113	porphobilinogen synthase activity
HLY11_08790	COG2175	clavaminate synthase activity
HLY11_08795	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HLY11_08805	COG4521	taurine ABC transporter
HLY11_08820	COG2271	Major facilitator Superfamily
HLY11_08825	COG1840	ABC-type Fe3 transport system, periplasmic component
HLY11_08835	COG3842	ATPase activity
HLY11_08850	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
HLY11_08855	COG3122	Protein conserved in bacteria
HLY11_08860	COG2814	Major facilitator Superfamily
HLY11_08865	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HLY11_08880	COG0596	Alpha beta hydrolase
HLY11_08895	COG1414	Transcriptional regulator
HLY11_08900	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HLY11_08945	COG3835	regulator
HLY11_08950	COG2807	transmembrane transport
HLY11_08960	COG0288	reversible hydration of carbon dioxide
HLY11_08965	COG0583	DNA-binding transcription factor activity
HLY11_08970	COG0402	S-adenosylhomocysteine deaminase activity
HLY11_08975	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HLY11_08980	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HLY11_08985	COG2079	MmgE PrpD family protein
HLY11_08990	COG0372	Belongs to the citrate synthase family
HLY11_08995	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
HLY11_09000	COG3829	transcription factor binding
HLY11_09010	COG1280	lysine exporter protein (LysE YggA)
HLY11_09025	COG1064	alcohol dehydrogenase
HLY11_09035	COG0402	S-adenosylhomocysteine deaminase activity
HLY11_09040	COG0549	Belongs to the carbamate kinase family
HLY11_09045	COG1304	FMN binding
HLY11_09050	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HLY11_09060	COG0666	response to abiotic stimulus
HLY11_09070	COG0583	DNA-binding transcription factor activity
HLY11_09075	COG2200	EAL domain
HLY11_09075	COG2771	luxR family
HLY11_09085	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HLY11_09110	COG3708	Transcriptional regulator
HLY11_09110	COG2207	Transcriptional regulator
HLY11_09115	COG1388	LysM domain
HLY11_09140	COG4221	oxidoreductase activity
HLY11_09145	COG0583	DNA-binding transcription factor activity
HLY11_09150	COG3729	General stress protein
HLY11_09155	COG3685	Protein conserved in bacteria
HLY11_09160	COG3685	Protein conserved in bacteria
HLY11_09165	COG3546	catalase activity
HLY11_09195	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HLY11_09215	COG2195	Cleaves the N-terminal amino acid of tripeptides
HLY11_09220	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
HLY11_09225	COG1690	Belongs to the RtcB family
HLY11_09230	COG0454	-acetyltransferase
HLY11_09255	COG0791	NLP P60 protein
HLY11_09260	COG3077	Addiction module antitoxin, RelB DinJ family
HLY11_09265	COG3041	Addiction module toxin RelE StbE family
HLY11_09270	COG3034	peptidoglycan biosynthetic process
HLY11_09275	COG0121	glutamine amidotransferase
HLY11_09285	COG1960	acyl-CoA dehydrogenase activity
HLY11_09295	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HLY11_09310	COG3209	COG3209 Rhs family protein
HLY11_09365	COG3501	Rhs element vgr protein
HLY11_09425	COG2885	chlorophyll binding
HLY11_09515	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HLY11_09525	COG2226	methyltransferase
HLY11_09535	COG0741	lytic transglycosylase activity
HLY11_09535	COG1388	LysM domain
HLY11_09540	COG2226	methyltransferase
HLY11_09550	COG0583	DNA-binding transcription factor activity
HLY11_09555	COG0656	L-ascorbic acid biosynthetic process
HLY11_09590	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HLY11_09595	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HLY11_09600	COG2011	ABC-type metal ion transport system permease component
HLY11_09605	COG1464	Belongs to the NlpA lipoprotein family
HLY11_09615	COG1720	tRNA m6t6A37 methyltransferase activity
HLY11_09625	COG0791	NLP P60 protein
HLY11_09630	COG3015	lipoprotein NlpE involved in copper resistance
HLY11_09635	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
HLY11_09640	COG4681	YaeQ
HLY11_09650	COG4568	rho-dependent transcription termination
HLY11_09655	COG0037	tRNA processing
HLY11_09660	COG0346	lactoylglutathione lyase activity
HLY11_09675	COG0587	DNA-directed DNA polymerase activity
HLY11_09700	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HLY11_09705	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
HLY11_09715	COG0750	zinc metalloprotease
HLY11_09720	COG0575	Belongs to the CDS family
HLY11_09725	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HLY11_09730	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HLY11_09755	COG0024	Methionine aminopeptidase
HLY11_09775	COG3835	regulator
HLY11_09780	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HLY11_09795	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HLY11_09800	COG2860	membrane
HLY11_09825	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HLY11_09830	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HLY11_09835	COG1120	ATPase activity
HLY11_09840	COG4774	siderophore transport
HLY11_09845	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HLY11_09850	COG1643	Atp-dependent helicase
HLY11_09855	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
HLY11_09865	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HLY11_09870	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HLY11_09875	COG0617	tRNA 3'-terminal CCA addition
HLY11_09880	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HLY11_09885	COG3539	Fimbrial protein
HLY11_09890	COG3121	Chaperone
HLY11_09895	COG3188	usher protein
HLY11_09900	COG3539	Fimbrial protein
HLY11_09930	COG5464	transposase or invertase
HLY11_09940	COG0726	polysaccharide deacetylase
HLY11_09945	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HLY11_09950	COG0842	Transport permease protein
HLY11_09955	COG1131	(ABC) transporter
HLY11_09960	COG0288	reversible hydration of carbon dioxide
HLY11_09965	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
HLY11_09970	COG4993	Dehydrogenase
HLY11_09975	COG2132	Multicopper oxidase
HLY11_10000	COG1049	propionate catabolic process, 2-methylcitrate cycle
HLY11_10005	COG3064	Membrane
HLY11_10010	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HLY11_10015	COG0508	dehydrogenase complex catalyzes the overall conversion of
HLY11_10020	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
HLY11_10025	COG2186	Transcriptional regulator
HLY11_10035	COG3725	Membrane protein required for beta-lactamase induction
HLY11_10040	COG3023	N-Acetylmuramoyl-L-alanine amidase
HLY11_10045	COG0157	Belongs to the NadC ModD family
HLY11_10050	COG4969	Belongs to the N-Me-Phe pilin family
HLY11_10055	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HLY11_10060	COG1459	type II secretion system
HLY11_10070	COG0237	dephospho-CoA kinase activity
HLY11_10085	COG0494	nUDIX hydrolase
HLY11_10105	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HLY11_10110	COG0849	cell division
HLY11_10115	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
HLY11_10120	COG1181	Belongs to the D-alanine--D-alanine ligase family
HLY11_10135	COG0772	Belongs to the SEDS family
HLY11_10140	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HLY11_10150	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HLY11_10155	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HLY11_10160	COG0768	penicillin binding
HLY11_10165	COG3116	cell division
HLY11_10180	COG1609	Transcriptional regulator
HLY11_10190	COG0440	acetolactate synthase activity
HLY11_10195	COG0028	Belongs to the TPP enzyme family
HLY11_10200	COG0583	DNA-binding transcription factor activity
HLY11_10230	COG2814	Major facilitator Superfamily
HLY11_10240	COG4533	DNA binding
HLY11_10250	COG4143	(ABC) transporter
HLY11_10255	COG1178	ABC-type Fe3 transport system permease component
HLY11_10265	COG3547	Transposase (IS116 IS110 IS902 family)
HLY11_10270	COG0586	Pfam SNARE associated Golgi protein
HLY11_10275	COG4977	sequence-specific DNA binding
HLY11_10280	COG1069	ribulokinase activity
HLY11_10290	COG0235	Class ii aldolase
HLY11_10295	COG0417	DNA replication proofreading
HLY11_10305	COG0564	pseudouridine synthase activity
HLY11_10315	COG1357	PFAM Pentapeptide repeats (8 copies)
HLY11_10320	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
HLY11_10330	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HLY11_10370	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HLY11_10390	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HLY11_10395	COG0505	Belongs to the CarA family
HLY11_10415	COG1047	Peptidyl-prolyl cis-trans
HLY11_10430	COG0196	riboflavin kinase activity
HLY11_10455	COG3121	Chaperone
HLY11_10460	COG3188	usher protein
HLY11_10470	COG0583	DNA-binding transcription factor activity
HLY11_10485	COG3119	arylsulfatase activity
HLY11_10515	COG4735	regulation of single-species biofilm formation
HLY11_10520	COG1584	GPR1 FUN34 yaaH family protein
HLY11_10525	COG0521	Mo-molybdopterin cofactor biosynthetic process
HLY11_10530	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HLY11_10535	COG1115	amino acid carrier protein
HLY11_10550	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HLY11_10560	COG0460	homoserine dehydrogenase
HLY11_10560	COG0527	aspartate kinase activity
HLY11_10570	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
HLY11_10580	COG0745	RESPONSE REGULATOR receiver
HLY11_10585	COG4452	Inner membrane protein CreD
HLY11_10590	COG2205	protein histidine kinase activity
HLY11_10595	COG0745	RESPONSE REGULATOR receiver
HLY11_10600	COG3045	CreA protein
HLY11_10605	COG2207	Transcriptional regulator
HLY11_10605	COG3708	Transcriptional regulator
HLY11_10625	COG0741	lytic transglycosylase activity
HLY11_10630	COG0488	(ABC) transporter
HLY11_10640	COG1056	cytidyltransferase-related domain
HLY11_10640	COG3172	ATPase kinase involved in NAD metabolism
HLY11_10645	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HLY11_10650	COG0560	Phosphoserine phosphatase
HLY11_10655	COG3726	membrane protein affecting hemolysin expression
HLY11_10690	COG1328	CTP reductase activity
HLY11_10695	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HLY11_10700	COG0084	hydrolase, TatD family'
HLY11_10705	COG4667	esterase of the alpha-beta hydrolase superfamily
HLY11_10715	COG2823	Periplasmic or secreted lipoprotein
HLY11_10725	COG1011	Hydrolase
HLY11_10730	COG0456	acetyltransferase
HLY11_10735	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
HLY11_10755	COG4114	ferric iron reductase
HLY11_10760	COG2197	response regulator
HLY11_10765	COG2197	response regulator
HLY11_10770	COG2966	Psort location CytoplasmicMembrane, score
HLY11_10785	COG1484	DNA-dependent DNA replication
HLY11_10800	COG1063	alcohol dehydrogenase
HLY11_10805	COG1802	Transcriptional regulator
HLY11_10810	COG2271	Major facilitator Superfamily
HLY11_10815	COG0840	transmembrane signaling receptor activity
HLY11_10825	COG1966	Carbon starvation protein
HLY11_10830	COG2879	small protein
HLY11_10835	COG0523	cobalamin synthesis protein
HLY11_10860	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
HLY11_10880	COG5457	Domain of unknown function (DUF1127)
HLY11_10885	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HLY11_10900	COG2814	Major facilitator Superfamily
HLY11_10905	COG2733	membrane
HLY11_10910	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
HLY11_10915	COG1924	4 iron, 4 sulfur cluster binding
HLY11_10930	COG3204	pilus organization
HLY11_10935	COG0477	Major facilitator Superfamily
HLY11_10940	COG1388	LysM domain
HLY11_10940	COG1470	cell adhesion involved in biofilm formation
HLY11_10950	COG3366	ferrous iron transmembrane transporter activity
HLY11_10955	COG0700	Nucleoside recognition
HLY11_10960	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HLY11_10965	COG0583	DNA-binding transcription factor activity
HLY11_10985	COG2186	Transcriptional regulator
HLY11_10990	COG0246	Mannitol dehydrogenase
HLY11_11000	COG0210	DNA helicase
HLY11_11005	COG1205	dead DEAH box helicase
HLY11_11005	COG1111	helicase
HLY11_11015	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HLY11_11090	COG2003	Belongs to the UPF0758 family
HLY11_11120	COG3596	GTP binding
HLY11_11125	COG2378	regulation of single-species biofilm formation
HLY11_11130	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
HLY11_11160	COG0582	viral genome integration into host DNA
HLY11_11170	COG1064	alcohol dehydrogenase
HLY11_11175	COG0433	COG0433 Predicted ATPase
HLY11_11180	COG0795	lipopolysaccharide-transporting ATPase activity
HLY11_11185	COG0795	lipopolysaccharide-transporting ATPase activity
HLY11_11195	COG2927	DNA polymerase III (CHI subunit)
HLY11_11200	COG0525	valine-tRNA ligase activity
HLY11_11210	COG0456	acetyltransferase
HLY11_11215	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
HLY11_11230	COG2731	YhcH YjgK YiaL family protein
HLY11_11235	COG1309	transcriptional regulator
HLY11_11240	COG1028	Short-chain dehydrogenase reductase Sdr
HLY11_11245	COG0251	oxidation-reduction process
HLY11_11265	COG0251	oxidation-reduction process
HLY11_11270	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HLY11_11280	COG1609	Transcriptional regulator
HLY11_11285	COG1263	PTS System
HLY11_11285	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HLY11_11290	COG0366	Alpha amylase catalytic
HLY11_11295	COG1328	CTP reductase activity
HLY11_11300	COG0602	queuosine metabolic process
HLY11_11305	COG2026	Addiction module toxin, RelE StbE family
HLY11_11310	COG3077	Addiction module antitoxin, RelB DinJ family
HLY11_11315	COG3783	Cytochrome b(562)
HLY11_11320	COG0312	modulator of DNA gyrase
HLY11_11330	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HLY11_11340	COG1172	Belongs to the binding-protein-dependent transport system permease family
HLY11_11345	COG1172	Belongs to the binding-protein-dependent transport system permease family
HLY11_11350	COG1129	ABC transporter
HLY11_11355	COG1879	ABC-type sugar transport system periplasmic component
HLY11_11360	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HLY11_11365	COG2337	Toxic component of a toxin-antitoxin (TA) module
HLY11_11370	COG2336	PFAM SpoVT AbrB
HLY11_11375	COG2105	PFAM AIG2 family protein
HLY11_11380	COG2911	Protein conserved in bacteria
HLY11_11385	COG0729	surface antigen
HLY11_11395	COG1253	flavin adenine dinucleotide binding
HLY11_11405	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
HLY11_11415	COG1218	3'(2'),5'-bisphosphate nucleotidase
HLY11_11420	COG0737	Belongs to the 5'-nucleotidase family
HLY11_11430	COG0697	spore germination
HLY11_11450	COG1113	amino acid transport
HLY11_11455	COG0545	Peptidyl-prolyl cis-trans isomerase
HLY11_11460	COG3061	Opacity-associated protein A
HLY11_11465	COG1309	transcriptional regulator
HLY11_11470	COG1028	Short-chain dehydrogenase reductase Sdr
HLY11_11480	COG4670	ketone body catabolic process
HLY11_11485	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HLY11_11490	COG2271	Major facilitator Superfamily
HLY11_11495	COG2030	dehydratase
HLY11_11515	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HLY11_11550	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HLY11_11555	COG3414	Phosphotransferase system galactitol-specific IIB component
HLY11_11560	COG3037	sugar-specific permease SgaT UlaA
HLY11_11575	COG1073	alpha beta
HLY11_11580	COG3650	response to hydrogen peroxide
HLY11_11590	COG1960	acyl-CoA dehydrogenase activity
HLY11_11595	COG0754	glutathionylspermidine amidase activity
HLY11_11600	COG5463	Belongs to the UPF0441 family
HLY11_11605	COG3766	membrane
HLY11_11615	COG1842	Phage shock protein A
HLY11_11620	COG3789	protein conserved in bacteria
HLY11_11625	COG2721	sulfolactate sulfo-lyase activity
HLY11_11630	COG2271	Major facilitator Superfamily
HLY11_11635	COG0329	Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA)
HLY11_11640	COG1414	Transcriptional regulator
HLY11_11645	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HLY11_11650	COG0557	exoribonuclease II activity
HLY11_11665	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
HLY11_11670	COG0330	HflC and HflK could
HLY11_11675	COG0330	HflC and HflK could
HLY11_11680	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HLY11_11700	COG0860	N-Acetylmuramoyl-L-alanine amidase
HLY11_11705	COG0802	atpase or kinase
HLY11_11710	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HLY11_11710	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HLY11_11715	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HLY11_11755	COG3264	Mechanosensitive ion channel
HLY11_11755	COG1511	domain protein
HLY11_11760	COG0531	amino acid
HLY11_11770	COG1053	succinate dehydrogenase
HLY11_11775	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HLY11_11790	COG3040	lipid binding
HLY11_11795	COG2076	Multidrug Resistance protein
HLY11_11800	COG5510	response to toxic substance
HLY11_11805	COG5510	response to toxic substance
HLY11_11815	COG1509	lysine 2,3-aminomutase activity
HLY11_11840	COG0531	amino acid
HLY11_11845	COG3030	protein affecting phage T7 exclusion by the F plasmid
HLY11_11850	COG1027	Aspartate ammonia-lyase
HLY11_11855	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HLY11_11865	COG4232	protein-disulfide reductase activity
HLY11_11870	COG1309	transcriptional regulator
HLY11_11880	COG3710	Transcriptional regulator
HLY11_11885	COG0531	amino acid
HLY11_11890	COG1982	Orn Lys Arg decarboxylase major
HLY11_11895	COG3104	oligopeptide transport
HLY11_11900	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HLY11_11915	COG2388	GCN5-related N-acetyl-transferase
HLY11_11920	COG3592	Divergent 4Fe-4S mono-cluster
HLY11_11925	COG3290	protein histidine kinase activity
HLY11_11930	COG4565	transcriptional regulatory protein
HLY11_11935	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HLY11_11940	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
HLY11_11940	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HLY11_11945	COG3647	Membrane
HLY11_11950	COG1486	melibiose metabolic process
HLY11_11955	COG2169	Transcriptional regulator
HLY11_11960	COG1982	Orn Lys Arg decarboxylase major
HLY11_11965	COG2207	Transcriptional regulator
HLY11_11970	COG0531	amino acid
HLY11_11975	COG2194	sulfuric ester hydrolase activity
HLY11_11980	COG0745	RESPONSE REGULATOR receiver
HLY11_11985	COG0642	Histidine kinase
HLY11_11995	COG0477	Major facilitator Superfamily
HLY11_12005	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
HLY11_12010	COG2824	Alkylphosphonate utilization operon protein PhnA
HLY11_12015	COG2764	glyoxalase bleomycin resistance protein dioxygenase
HLY11_12020	COG0456	acetyltransferase
HLY11_12035	COG1129	ABC transporter
HLY11_12040	COG1172	Belongs to the binding-protein-dependent transport system permease family
HLY11_12070	COG2015	COG2015, Alkyl sulfatase and related hydrolases
HLY11_12080	COG1566	PFAM secretion protein HlyD family protein
HLY11_12085	COG1289	transmembrane transporter activity
HLY11_12100	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
HLY11_12110	COG1301	dicarboxylic acid transport
HLY11_12115	COG4235	cytochrome complex assembly
HLY11_12120	COG3088	subunit of a heme lyase
HLY11_12125	COG1138	Cytochrome C-type biogenesis protein
HLY11_12130	COG3301	Polysulphide reductase, NrfD
HLY11_12135	COG0437	4 iron, 4 sulfur cluster binding
HLY11_12140	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
HLY11_12150	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HLY11_12155	COG3162	membrane
HLY11_12165	COG1357	PFAM Pentapeptide repeats (8 copies)
HLY11_12170	COG0025	NhaP-type Na H and K H
HLY11_12175	COG2252	PERMEase
HLY11_12180	COG0789	Transcriptional regulator
HLY11_12185	COG2207	Transcriptional regulator
HLY11_12190	COG4943	cyclic-guanylate-specific phosphodiesterase activity
HLY11_12205	COG0629	single-stranded DNA binding
HLY11_12210	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HLY11_12215	COG2315	Protein conserved in bacteria
HLY11_12220	COG0432	Pfam Uncharacterised protein family UPF0047
HLY11_12225	COG3700	Belongs to the class B bacterial acid phosphatase family
HLY11_12235	COG1448	Aminotransferase
HLY11_12245	COG3201	nicotinamide mononucleotide transporter
HLY11_12250	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HLY11_12255	COG0305	Participates in initiation and elongation during chromosome replication
HLY11_12260	COG0604	alcohol dehydrogenase
HLY11_12270	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HLY11_12280	COG0735	belongs to the Fur family
HLY11_12285	COG3237	CsbD-like
HLY11_12290	COG0534	Mate efflux family protein
HLY11_12300	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HLY11_12320	COG1357	PFAM Pentapeptide repeats (8 copies)
HLY11_12335	COG3842	ATPase activity
HLY11_12340	COG2182	Extracellular solute-binding protein
HLY11_12345	COG1175	transmembrane transport
HLY11_12350	COG3833	ABC-type maltose transport systems, permease component
HLY11_12365	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HLY11_12390	COG0527	aspartate kinase activity
HLY11_12400	COG1187	pseudouridine synthase activity
HLY11_12445	COG1283	sodium-dependent phosphate transmembrane transporter activity
HLY11_12450	COG0646	methionine synthase
HLY11_12450	COG1410	methionine synthase
HLY11_12455	COG1414	Transcriptional regulator
HLY11_12465	COG2224	Isocitrate lyase
HLY11_12470	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
HLY11_12480	COG0456	acetyltransferase
HLY11_12510	COG0151	Belongs to the GarS family
HLY11_12515	COG2204	response regulator
HLY11_12520	COG4191	Histidine kinase
HLY11_12525	COG3678	ATP-independent chaperone mediated protein folding
HLY11_12540	COG3068	Protein conserved in bacteria
HLY11_12575	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HLY11_12580	COG2104	thiamine diphosphate biosynthetic process
HLY11_12590	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HLY11_12630	COG0250	Participates in transcription elongation, termination and antitermination
HLY11_12635	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HLY11_12670	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
HLY11_12670	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
HLY11_12675	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HLY11_12700	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HLY11_12705	COG4206	TonB-dependent receptor
HLY11_12710	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HLY11_12720	COG1309	transcriptional regulator
HLY11_12730	COG0583	DNA-binding transcription factor activity
HLY11_12735	COG2271	Major facilitator Superfamily
HLY11_12740	COG4948	Mandelate Racemase Muconate Lactonizing
HLY11_12755	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HLY11_12770	COG2194	sulfuric ester hydrolase activity
HLY11_12775	COG2207	Transcriptional regulator
HLY11_12780	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HLY11_12785	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HLY11_12795	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HLY11_12800	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HLY11_12805	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HLY11_12805	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HLY11_12805	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HLY11_12810	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HLY11_12815	COG0371	Dehydrogenase
HLY11_12820	COG3738	Protein conserved in bacteria
HLY11_12825	COG0697	spore germination
HLY11_12835	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HLY11_12840	COG2190	(PTS) system
HLY11_12840	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HLY11_12840	COG1263	PTS System
HLY11_12845	COG1609	Transcriptional regulator
HLY11_12855	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HLY11_12865	COG0737	Belongs to the 5'-nucleotidase family
HLY11_12875	COG0460	homoserine dehydrogenase
HLY11_12875	COG0527	aspartate kinase activity
HLY11_12880	COG0626	cystathionine gamma-synthase activity
HLY11_12890	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
HLY11_12900	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HLY11_12905	COG1609	Transcriptional regulator
HLY11_12910	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HLY11_12925	COG1575	Belongs to the MenA family. Type 1 subfamily
HLY11_12950	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HLY11_12960	COG1494	fructose-1,6-bisphosphatase
HLY11_12970	COG0589	response to stress
HLY11_12975	COG3691	Protein conserved in bacteria
HLY11_12980	COG3152	Membrane
HLY11_13000	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
HLY11_13015	COG3678	ATP-independent chaperone mediated protein folding
HLY11_13020	COG0745	RESPONSE REGULATOR receiver
HLY11_13025	COG2205	protein histidine kinase activity
HLY11_13030	COG2258	MOSC domain
HLY11_13040	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HLY11_13085	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HLY11_13090	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HLY11_13090	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HLY11_13095	COG1363	Peptidase, m42
HLY11_13100	COG3711	transcriptional antiterminator
HLY11_13100	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HLY11_13115	COG0326	Molecular chaperone. Has ATPase activity
HLY11_13130	COG0437	4 iron, 4 sulfur cluster binding
HLY11_13135	COG2864	formate dehydrogenase
HLY11_13145	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HLY11_13160	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
HLY11_13175	COG0456	acetyltransferase
HLY11_13190	COG1011	Hydrolase
HLY11_13195	COG1349	DNA-binding transcription factor activity
HLY11_13200	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HLY11_13205	COG2084	Dehydrogenase
HLY11_13210	COG3684	Belongs to the aldolase LacD family
HLY11_13215	COG2942	2-epimerase
HLY11_13220	COG2017	converts alpha-aldose to the beta-anomer
HLY11_13230	COG1501	Belongs to the glycosyl hydrolase 31 family
HLY11_13235	COG2211	Major facilitator Superfamily
HLY11_13240	COG2211	Major facilitator Superfamily
HLY11_13245	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
HLY11_13265	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HLY11_13275	COG0561	phosphatase activity
HLY11_13285	COG0174	glutamine synthetase
HLY11_13290	COG3852	Histidine kinase
HLY11_13295	COG2204	response regulator
HLY11_13305	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HLY11_13320	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HLY11_13320	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HLY11_13325	COG0204	Acyl-transferase
HLY11_13330	COG5339	Protein conserved in bacteria
HLY11_13335	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HLY11_13340	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HLY11_13345	COG3084	Protein conserved in bacteria
HLY11_13350	COG0746	molybdenum cofactor guanylyltransferase activity
HLY11_13355	COG1763	Mo-molybdopterin cofactor biosynthetic process
HLY11_13385	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
HLY11_13390	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HLY11_13395	COG1739	Uncharacterized protein family UPF0029
HLY11_13415	COG0543	2 iron, 2 sulfur cluster binding
HLY11_13420	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HLY11_13425	COG0250	Participates in transcription elongation, termination and antitermination
HLY11_13435	COG0805	protein transport
HLY11_13440	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HLY11_13445	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HLY11_13455	COG3165	ubiquinone biosynthetic process from chorismate
HLY11_13465	COG1322	Protein conserved in bacteria
HLY11_13470	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
HLY11_13475	COG0412	Dienelactone hydrolase
HLY11_13485	COG0583	DNA-binding transcription factor activity
HLY11_13490	COG0697	spore germination
HLY11_13495	COG0561	phosphatase activity
HLY11_13500	COG2267	carboxylic ester hydrolase activity
HLY11_13505	COG1280	lysine exporter protein (LysE YggA)
HLY11_13510	COG1280	lysine exporter protein (LysE YggA)
HLY11_13515	COG0514	ATP-dependent DNA helicase (RecQ)
HLY11_13525	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
HLY11_13530	COG2050	protein possibly involved in aromatic compounds catabolism
HLY11_13535	COG2962	Rard protein
HLY11_13545	COG0598	Magnesium transport protein CorA
HLY11_13550	COG3698	Phosphodiester glycosidase
HLY11_13555	COG0210	DNA helicase
HLY11_13560	COG1011	Hydrolase
HLY11_13570	COG3159	Protein conserved in bacteria
HLY11_13580	COG5567	small periplasmic lipoprotein
HLY11_13600	COG3072	Adenylate cyclase
HLY11_13610	COG1587	Uroporphyrinogen-III synthase
HLY11_13615	COG2959	enzyme of heme biosynthesis
HLY11_13620	COG3071	HemY protein
HLY11_13630	COG3119	arylsulfatase activity
HLY11_13635	COG0641	radical SAM
HLY11_13660	COG1113	amino acid transport
HLY11_13680	COG2244	polysaccharide biosynthetic process
HLY11_13685	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HLY11_13690	COG0456	acetyltransferase
HLY11_13695	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
HLY11_13700	COG1088	dTDP-glucose 4,6-dehydratase activity
HLY11_13705	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
HLY11_13710	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HLY11_13715	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
HLY11_13720	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HLY11_13725	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
HLY11_13735	COG3118	belongs to the thioredoxin family
HLY11_13750	COG0210	DNA helicase
HLY11_13755	COG3692	DNA binding
HLY11_13760	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HLY11_13770	COG0583	DNA-binding transcription factor activity
HLY11_13775	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HLY11_13785	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HLY11_13790	COG3978	acetolactate synthase activity
HLY11_13810	COG0606	chelatase, subunit chli
HLY11_13815	COG3085	chromosome segregation
HLY11_13855	COG2186	Transcriptional regulator
HLY11_13860	COG0477	Major facilitator Superfamily
HLY11_13865	COG1609	Transcriptional regulator
HLY11_13870	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HLY11_13875	COG1879	ABC-type sugar transport system periplasmic component
HLY11_13880	COG1172	Belongs to the binding-protein-dependent transport system permease family
HLY11_13885	COG1129	ABC transporter
HLY11_13915	COG1522	sequence-specific DNA binding
HLY11_13920	COG0716	FMN binding
HLY11_13935	COG3312	ion transport
HLY11_13985	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HLY11_13990	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HLY11_13995	COG0573	inorganic phosphate transmembrane transporter activity
HLY11_14000	COG0581	inorganic phosphate transmembrane transporter activity
HLY11_14005	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HLY11_14010	COG0704	Plays a role in the regulation of phosphate uptake
HLY11_14020	COG3539	Fimbrial protein
HLY11_14025	COG3539	Fimbrial protein
HLY11_14030	COG3121	Chaperone
HLY11_14035	COG3188	usher protein
HLY11_14065	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HLY11_14070	COG2252	PERMEase
HLY11_14075	COG0431	NADPH-dependent FMN reductase
HLY11_14080	COG2091	lysine biosynthetic process via aminoadipic acid
HLY11_14095	COG0814	amino acid
HLY11_14150	COG0592	DNA-directed DNA polymerase activity
HLY11_14160	COG0187	DNA topoisomerase II activity
HLY11_14165	COG3753	Protein conserved in bacteria
HLY11_14170	COG0561	phosphatase activity
HLY11_14180	COG2186	Transcriptional regulator
HLY11_14185	COG3734	2-keto-3-deoxy-galactonokinase
HLY11_14190	COG0800	Aldolase
HLY11_14200	COG2271	Major facilitator Superfamily
HLY11_14210	COG0823	Involved in the tonB-independent uptake of proteins
HLY11_14215	COG5645	(Lipo)protein
HLY11_14235	COG2188	Transcriptional regulator
HLY11_14250	COG2207	Transcriptional regulator
HLY11_14255	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HLY11_14260	COG3119	arylsulfatase activity
HLY11_14270	COG2149	membrane
HLY11_14280	COG0641	radical SAM
HLY11_14285	COG2814	Major facilitator Superfamily
HLY11_14300	COG0028	Belongs to the TPP enzyme family
HLY11_14305	COG0440	acetolactate synthase activity
HLY11_14320	COG2197	response regulator
HLY11_14325	COG3851	Histidine kinase
HLY11_14330	COG2271	Major facilitator Superfamily
HLY11_14335	COG2271	Major facilitator Superfamily
HLY11_14345	COG2252	PERMEase
HLY11_14370	COG1388	LysM domain
HLY11_14370	COG2373	Large extracellular alpha-helical protein
HLY11_14370	COG4932	domain protein
HLY11_14400	COG0457	Tetratricopeptide repeat
HLY11_14410	COG1464	Belongs to the NlpA lipoprotein family
HLY11_14415	COG0697	spore germination
HLY11_14420	COG2814	Major facilitator Superfamily
HLY11_14435	COG2211	Major facilitator Superfamily
HLY11_14440	COG1501	Belongs to the glycosyl hydrolase 31 family
HLY11_14445	COG2982	Protein involved in outer membrane biogenesis
HLY11_14450	COG2233	PERMEase
HLY11_14455	COG0786	glutamate:sodium symporter activity
HLY11_14460	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HLY11_14465	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HLY11_14470	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HLY11_14480	COG0194	GDP metabolic process
HLY11_14490	COG2860	membrane
HLY11_14495	COG3645	SOS response
HLY11_14500	COG1561	YicC-like family, N-terminal region
HLY11_14525	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HLY11_14545	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HLY11_14555	COG1519	Transferase
HLY11_14560	COG0859	PFAM glycosyl transferase family 9
HLY11_14565	COG0438	transferase activity, transferring glycosyl groups
HLY11_14570	COG0515	serine threonine protein kinase
HLY11_14575	COG1442	glycosyl transferase family 8
HLY11_14580	COG0438	transferase activity, transferring glycosyl groups
HLY11_14585	COG1442	glycosyl transferase family 8
HLY11_14590	COG1442	glycosyl transferase family 8
HLY11_14595	COG3642	lipopolysaccharide core region biosynthetic process
HLY11_14605	COG0859	PFAM glycosyl transferase family 9
HLY11_14610	COG3307	-O-antigen
HLY11_14615	COG0859	PFAM glycosyl transferase family 9
HLY11_14620	COG0859	PFAM glycosyl transferase family 9
HLY11_14630	COG0156	8-amino-7-oxononanoate synthase activity
HLY11_14640	COG1216	Glycosyl transferase, family 2
HLY11_14645	COG2861	carbohydrate metabolic process
HLY11_14650	COG4942	peptidase
HLY11_14660	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HLY11_14665	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HLY11_14680	COG1045	serine acetyltransferase
HLY11_14685	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HLY11_14695	COG2186	Transcriptional regulator
HLY11_14700	COG1620	l-lactate permease
HLY11_14705	COG5295	Hep Hag repeat protein
HLY11_14725	COG3722	fumarate hydratase activity
HLY11_14735	COG2213	PTS system mannitol-specific
HLY11_14735	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HLY11_14745	COG1566	PFAM secretion protein HlyD family protein
HLY11_14750	COG0625	glutathione transferase activity
HLY11_14760	COG3276	selenocysteine insertion sequence binding
HLY11_14770	COG1012	belongs to the aldehyde dehydrogenase family
HLY11_14785	COG1566	PFAM secretion protein HlyD family protein
HLY11_14790	COG0583	DNA-binding transcription factor activity
HLY11_14795	COG3713	MltA-interacting MipA family protein
HLY11_14805	COG2211	Major facilitator Superfamily
HLY11_14815	COG0235	Class ii aldolase
HLY11_14820	COG3623	hexulose-6-phosphate isomerase
HLY11_14825	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
HLY11_14830	COG1070	Carbohydrate kinase
HLY11_14835	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HLY11_14840	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HLY11_14845	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
HLY11_14850	COG2731	YhcH YjgK YiaL family protein
HLY11_14860	COG1414	Transcriptional regulator
HLY11_14865	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HLY11_14870	COG3977	Valine--pyruvate aminotransferase
HLY11_14875	COG0366	Alpha amylase catalytic
HLY11_14880	COG2992	FlgJ-related protein
HLY11_14885	COG1609	Transcriptional regulator
HLY11_14885	COG2207	Transcriptional regulator
HLY11_14890	COG4214	carbohydrate transport
HLY11_14900	COG4213	ABC transporter substrate-binding protein
HLY11_14910	COG1070	Carbohydrate kinase
HLY11_14915	COG4682	membrane
HLY11_14920	COG4682	membrane
HLY11_14925	COG3274	enterobacterial common antigen metabolic process
HLY11_14965	COG1278	Cold shock
HLY11_14970	COG2944	sequence-specific DNA binding
HLY11_14985	COG2885	chlorophyll binding
HLY11_14990	COG0243	molybdopterin cofactor binding
HLY11_14995	COG0456	acetyltransferase
HLY11_15000	COG2818	Glycosylase
HLY11_15005	COG5571	outer membrane autotransporter
HLY11_15010	COG2223	nitrite transmembrane transporter activity
HLY11_15040	COG2194	sulfuric ester hydrolase activity
HLY11_15050	COG0747	negative chemotaxis
HLY11_15055	COG0601	transmembrane transport
HLY11_15060	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HLY11_15065	COG0444	Belongs to the ABC transporter superfamily
HLY11_15070	COG4608	Belongs to the ABC transporter superfamily
HLY11_15075	COG0814	amino acid
HLY11_15095	COG2194	sulfuric ester hydrolase activity
HLY11_15120	COG1215	transferase activity, transferring glycosyl groups
HLY11_15125	COG1215	transferase activity, transferring glycosyl groups
HLY11_15130	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
HLY11_15135	COG0457	Tetratricopeptide repeat
HLY11_15135	COG3118	belongs to the thioredoxin family
HLY11_15140	COG2200	EAL domain
HLY11_15140	COG2199	diguanylate cyclase activity
HLY11_15150	COG0612	Peptidase, M16
HLY11_15180	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HLY11_15185	COG2200	EAL domain
HLY11_15190	COG2982	Protein involved in outer membrane biogenesis
HLY11_15195	COG0477	Major facilitator Superfamily
HLY11_15200	COG1295	ribonuclease BN
HLY11_15205	COG0583	DNA-binding transcription factor activity
HLY11_15210	COG2197	response regulator
HLY11_15220	COG1858	cytochrome C peroxidase
HLY11_15225	COG0076	glutamate decarboxylase activity
HLY11_15230	COG2207	Transcriptional regulator
HLY11_15235	COG2207	Transcriptional regulator
HLY11_15240	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HLY11_15245	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HLY11_15255	COG2771	luxR family
HLY11_15260	COG3247	response to pH
HLY11_15275	COG1285	pathogenesis
HLY11_15280	COG2197	response regulator
HLY11_15285	COG3065	identical protein binding
HLY11_15295	COG1393	Belongs to the ArsC family
HLY11_15300	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HLY11_15305	COG0640	Transcriptional regulator
HLY11_15310	COG0675	Transposase, IS605 OrfB family
HLY11_15325	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HLY11_15330	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
HLY11_15335	COG0339	signal peptide processing
HLY11_15345	COG3104	oligopeptide transport
HLY11_15350	COG0589	response to stress
HLY11_15360	COG0306	phosphate transporter
HLY11_15365	COG2081	HI0933 family
HLY11_15385	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HLY11_15390	COG0842	Transport permease protein
HLY11_15390	COG1129	ABC transporter
HLY11_15395	COG0842	Transport permease protein
HLY11_15420	COG0444	Belongs to the ABC transporter superfamily
HLY11_15425	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HLY11_15430	COG0601	transmembrane transport
HLY11_15435	COG0747	negative chemotaxis
HLY11_15440	COG2091	lysine biosynthetic process via aminoadipic acid
HLY11_15445	COG0628	permease
HLY11_15460	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
HLY11_15485	COG3714	YhhN family
HLY11_15495	COG3776	membrane
HLY11_15500	COG0742	ribosomal rna small subunit methyltransferase
HLY11_15505	COG0552	protein localization to endoplasmic reticulum
HLY11_15510	COG2884	Cell division ATP-binding protein ftsE
HLY11_15515	COG2177	Part of the ABC transporter FtsEX involved in
HLY11_15520	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HLY11_15525	COG0683	leucine binding
HLY11_15540	COG0456	acetyltransferase
HLY11_15545	COG0683	leucine binding
HLY11_15550	COG0559	Belongs to the binding-protein-dependent transport system permease family
HLY11_15555	COG4177	L-phenylalanine transmembrane transporter activity
HLY11_15560	COG0411	ABC transporter
HLY11_15565	COG0410	ABC transporter
HLY11_15575	COG1653	transport
HLY11_15580	COG1175	transmembrane transport
HLY11_15595	COG0584	glycerophosphoryl diester phosphodiesterase
HLY11_15605	COG0405	Gamma-glutamyltransferase
HLY11_15610	COG1247	-acetyltransferase
HLY11_15615	COG0673	inositol 2-dehydrogenase activity
HLY11_15620	COG1741	Belongs to the pirin family
HLY11_15625	COG1609	Transcriptional regulator
HLY11_15630	COG3265	gluconokinase activity
HLY11_15635	COG2610	gluconate transmembrane transporter activity
HLY11_15640	COG0514	ATP-dependent DNA helicase (RecQ)
HLY11_15650	COG2095	MarC family integral membrane protein
HLY11_15655	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HLY11_15680	COG0058	SHG alpha-glucan phosphorylase activity
HLY11_15685	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HLY11_15725	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HLY11_15740	COG1349	DNA-binding transcription factor activity
HLY11_15745	COG4650	regulator
HLY11_15750	COG1690	Belongs to the RtcB family
HLY11_15775	COG0058	SHG alpha-glucan phosphorylase activity
HLY11_15780	COG1640	4-alpha-glucanotransferase
HLY11_15785	COG2610	gluconate transmembrane transporter activity
HLY11_15795	COG1040	competence protein
HLY11_15815	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
HLY11_15820	COG1918	ferrous iron import across plasma membrane
HLY11_15825	COG2183	response to ionizing radiation
HLY11_15830	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HLY11_15835	COG0745	RESPONSE REGULATOR receiver
HLY11_15840	COG2205	protein histidine kinase activity
HLY11_15860	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
HLY11_15870	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HLY11_15875	COG1011	Hydrolase
HLY11_15885	COG0494	nUDIX hydrolase
HLY11_15890	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
HLY11_15895	COG4972	Pilus assembly protein
HLY11_15900	COG3166	PFAM Fimbrial assembly family protein
HLY11_15915	COG4796	Type ii and iii secretion system protein
HLY11_15930	COG3266	domain, Protein
HLY11_15935	COG0338	D12 class N6 adenine-specific DNA methyltransferase
HLY11_15940	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HLY11_15950	COG0180	Tryptophanyl-tRNA synthetase
HLY11_15955	COG2188	Transcriptional regulator
HLY11_15965	COG3457	Alanine racemase
HLY11_15970	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
HLY11_15975	COG1735	metal-dependent hydrolase with the TIM-barrel fold
HLY11_15990	COG0626	cystathionine gamma-synthase activity
HLY11_15995	COG2188	Transcriptional regulator
HLY11_16005	COG1082	Xylose isomerase domain protein TIM barrel
HLY11_16010	COG2222	sugar isomerase
HLY11_16015	COG0531	amino acid
HLY11_16030	COG2116	formate transmembrane transporter activity
HLY11_16035	COG2146	nitrite reductase [NAD(P)H] activity
HLY11_16040	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HLY11_16050	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HLY11_16060	COG2184	nucleotidyltransferase activity
HLY11_16065	COG0512	Glutamine amidotransferase of anthranilate synthase
HLY11_16070	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HLY11_16075	COG1289	transmembrane transporter activity
HLY11_16080	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HLY11_16085	COG1765	OsmC-like protein
HLY11_16090	COG3954	Phosphoribulokinase
HLY11_16100	COG0429	hydrolase of the alpha beta-hydrolase fold
HLY11_16105	COG0488	(ABC) transporter
HLY11_16120	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
HLY11_16125	COG1047	Peptidyl-prolyl cis-trans
HLY11_16135	COG0545	Peptidyl-prolyl cis-trans isomerase
HLY11_16140	COG2964	Protein conserved in bacteria
HLY11_16180	COG3979	chitinase
HLY11_16185	COG2906	2 iron, 2 sulfur cluster binding
HLY11_16190	COG2193	ferroxidase activity
HLY11_16195	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
HLY11_16200	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
HLY11_16205	COG3297	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
HLY11_16210	COG3156	type II secretion system protein K
HLY11_16215	COG4795	General secretion pathway protein
HLY11_16220	COG2165	general secretion pathway protein
HLY11_16225	COG2165	general secretion pathway protein
HLY11_16230	COG2165	general secretion pathway protein
HLY11_16235	COG1459	type II secretion system
HLY11_16240	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HLY11_16245	COG1450	Type ii and iii secretion system protein
HLY11_16250	COG3031	protein transport across the cell outer membrane
HLY11_16255	COG3409	Peptidoglycan-binding domain 1 protein
HLY11_16255	COG3267	Type II secretory pathway component ExeA
HLY11_16280	COG0089	rRNA binding
HLY11_16370	COG0201	protein transport
HLY11_16410	COG0789	Transcriptional regulator
HLY11_16415	COG3036	rescue of stalled ribosome
HLY11_16425	COG0569	domain protein
HLY11_16445	COG0758	DNA mediated transformation
HLY11_16455	COG0551	DNA topoisomerase type I activity
HLY11_16475	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HLY11_16515	COG1126	abc transporter atp-binding protein
HLY11_16520	COG0765	amino acid transport
HLY11_16525	COG4597	amino acid ABC transporter
HLY11_16530	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HLY11_16540	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HLY11_16545	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HLY11_16550	COG1309	transcriptional regulator
HLY11_16560	COG2189	Belongs to the N(4) N(6)-methyltransferase family
HLY11_16570	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HLY11_16580	COG4145	pantothenate transmembrane transporter activity
HLY11_16585	COG3924	membrane
HLY11_16590	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HLY11_16595	COG1349	DNA-binding transcription factor activity
HLY11_16605	COG1879	ABC-type sugar transport system periplasmic component
HLY11_16610	COG1129	ABC transporter
HLY11_16615	COG1172	Belongs to the binding-protein-dependent transport system permease family
HLY11_16620	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HLY11_16630	COG0439	Biotin carboxylase
HLY11_16635	COG0511	ligase activity, forming carbon-carbon bonds
HLY11_16645	COG0604	alcohol dehydrogenase
HLY11_16650	COG2199	diguanylate cyclase activity
HLY11_16650	COG2200	EAL domain
HLY11_16655	COG1077	Cell shape determining protein MreB Mrl
HLY11_16660	COG1792	Involved in formation and maintenance of cell shape
HLY11_16665	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
HLY11_16675	COG1530	ribonuclease E activity
HLY11_16680	COG3164	Protein of unknown function
HLY11_16685	COG0312	modulator of DNA gyrase
HLY11_16690	COG0583	DNA-binding transcription factor activity
HLY11_16710	COG2732	(Barnase) inhibitor
HLY11_16730	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HLY11_16735	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HLY11_16740	COG3105	Protein conserved in bacteria
HLY11_16745	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
HLY11_16760	COG0625	glutathione transferase activity
HLY11_16765	COG2969	positive regulation of protein catabolic process
HLY11_16770	COG3069	C4-dicarboxylate transmembrane transporter activity
HLY11_16800	COG2731	YhcH YjgK YiaL family protein
HLY11_16805	COG4804	nuclease activity
HLY11_16810	COG0493	'glutamate synthase
HLY11_16815	COG0070	glutamate synthase
HLY11_16815	COG0069	glutamate synthase activity
HLY11_16815	COG0067	glutamate synthase
HLY11_16820	COG1242	4 iron, 4 sulfur cluster binding
HLY11_16825	COG0784	Response regulator, receiver
HLY11_16825	COG2198	Histidine kinase
HLY11_16825	COG5002	protein histidine kinase activity
HLY11_16830	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
HLY11_16840	COG0515	serine threonine protein kinase
HLY11_16845	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HLY11_16860	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HLY11_16865	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
HLY11_16870	COG1137	ATPase activity
HLY11_16875	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
HLY11_16880	COG3117	lipopolysaccharide transmembrane transporter activity
HLY11_16885	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
HLY11_16890	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HLY11_16890	COG0517	IMP dehydrogenase activity
HLY11_16895	COG0530	calcium, potassium:sodium antiporter activity
HLY11_16900	COG1127	ABC transporter
HLY11_16905	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HLY11_16910	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HLY11_16915	COG2854	intermembrane phospholipid transfer
HLY11_16920	COG3113	response to antibiotic
HLY11_16925	COG5007	Belongs to the BolA IbaG family
HLY11_16935	COG3423	Transcriptional regulator
HLY11_16940	COG0142	geranyltranstransferase activity
HLY11_16955	COG0697	spore germination
HLY11_16965	COG2027	D-alanyl-D-alanine carboxypeptidase
HLY11_16970	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HLY11_16975	COG1534	Rna-binding protein
HLY11_16985	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HLY11_16990	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HLY11_17000	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HLY11_17010	COG2194	sulfuric ester hydrolase activity
HLY11_17030	COG0195	Participates in both transcription termination and antitermination
HLY11_17070	COG0513	Belongs to the DEAD box helicase family
HLY11_17075	COG0814	amino acid
HLY11_17080	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HLY11_17085	COG0826	peptidase U32
HLY11_17090	COG0826	peptidase U32
HLY11_17095	COG3154	lipid carrier protein
HLY11_17100	COG3153	acetyltransferase
HLY11_17115	COG0693	protein deglycase activity
HLY11_17120	COG0702	epimerase
HLY11_17125	COG0701	Predicted permease
HLY11_17130	COG2823	Periplasmic or secreted lipoprotein
HLY11_17145	COG3107	peptidoglycan biosynthetic process
HLY11_17150	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HLY11_17165	COG0363	glucosamine-6-phosphate deaminase activity
HLY11_17170	COG3716	PTS system mannose fructose sorbose family IID component
HLY11_17175	COG3715	PTS system
HLY11_17180	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HLY11_17190	COG2222	sugar isomerase
HLY11_17195	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HLY11_17200	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HLY11_17205	COG3716	PTS system mannose fructose sorbose family IID component
HLY11_17215	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HLY11_17225	COG1349	DNA-binding transcription factor activity
HLY11_17235	COG2002	toxin-antitoxin pair type II binding
HLY11_17240	COG1349	DNA-binding transcription factor activity
HLY11_17245	COG1940	carbohydrate kinase activity
HLY11_17250	COG0673	inositol 2-dehydrogenase activity
HLY11_17260	COG1486	melibiose metabolic process
HLY11_17265	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HLY11_17270	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HLY11_17275	COG2721	sulfolactate sulfo-lyase activity
HLY11_17280	COG2271	Major facilitator Superfamily
HLY11_17290	COG2084	Dehydrogenase
HLY11_17295	COG1929	Belongs to the glycerate kinase type-1 family
HLY11_17320	COG0583	DNA-binding transcription factor activity
HLY11_17325	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HLY11_17335	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HLY11_17340	COG1882	Formate acetyltransferase
HLY11_17345	COG0251	oxidation-reduction process
HLY11_17350	COG1760	l-serine dehydratase
HLY11_17355	COG0814	amino acid
HLY11_17370	COG1741	Belongs to the pirin family
HLY11_17375	COG0583	DNA-binding transcription factor activity
HLY11_17380	COG3152	Membrane
HLY11_17385	COG0435	Glutathione S-transferase
HLY11_17390	COG2259	Doxx family
HLY11_17400	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
HLY11_17405	COG4575	ribosome binding
HLY11_17410	COG1422	Protein of unknown function (DUF1090)
HLY11_17420	COG0586	Pfam SNARE associated Golgi protein
HLY11_17425	COG2186	Transcriptional regulator
HLY11_17450	COG2271	Major facilitator Superfamily
HLY11_17460	COG2721	sulfolactate sulfo-lyase activity
HLY11_17470	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
HLY11_17475	COG0861	Integral membrane protein TerC family
HLY11_17480	COG0673	inositol 2-dehydrogenase activity
HLY11_17485	COG2949	membrane
HLY11_17490	COG1451	nucleotide metabolic process
HLY11_17505	COG5499	transcription regulator containing HTH domain
HLY11_17510	COG1902	pentaerythritol trinitrate reductase activity
HLY11_17510	COG0446	pyridine nucleotide-disulphide oxidoreductase
HLY11_17515	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
HLY11_17515	COG3408	Glycogen debranching enzyme
HLY11_17525	COG0531	amino acid
HLY11_17530	COG2731	YhcH YjgK YiaL family protein
HLY11_17535	COG3250	beta-galactosidase activity
HLY11_17540	COG1609	Transcriptional regulator
HLY11_17545	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HLY11_17555	COG0840	transmembrane signaling receptor activity
HLY11_17560	COG1695	Transcriptional regulator
HLY11_17565	COG2375	cellular response to nickel ion
HLY11_17580	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HLY11_17585	COG0358	DNA primase activity
HLY11_17590	COG0828	Belongs to the bacterial ribosomal protein bS21 family
HLY11_17600	COG0471	metal ion transport
HLY11_17605	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HLY11_17610	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
HLY11_17615	COG0583	DNA-binding transcription factor activity
HLY11_17625	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HLY11_17640	COG4991	sh3 domain protein
HLY11_17645	COG3025	triphosphatase activity
HLY11_17670	COG2268	Band 7 protein
HLY11_17675	COG1585	Membrane protein implicated in regulation of membrane protease activity
HLY11_17705	COG3384	dioxygenase
HLY11_17710	COG0754	glutathionylspermidine amidase activity
HLY11_17720	COG1538	Outer membrane efflux protein
HLY11_17725	COG0494	nUDIX hydrolase
HLY11_17730	COG3151	Protein conserved in bacteria
HLY11_17735	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HLY11_17740	COG3150	esterase
HLY11_17745	COG0187	DNA topoisomerase II activity
HLY11_17765	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HLY11_17785	COG2211	Major facilitator Superfamily
HLY11_17790	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
HLY11_17795	COG2249	NAD(P)H dehydrogenase (quinone) activity
HLY11_17800	COG0642	Histidine kinase
HLY11_17805	COG0745	RESPONSE REGULATOR receiver
HLY11_17810	COG3111	PFAM Bacterial OB fold (BOF) protein
HLY11_17815	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
HLY11_17825	COG2944	sequence-specific DNA binding
HLY11_17830	COG4166	transmembrane transport
HLY11_17835	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HLY11_17840	COG0204	Acyl-transferase
HLY11_17845	COG2132	Multicopper oxidase
HLY11_17860	COG1032	radical SAM domain protein
HLY11_17875	COG4238	major outer membrane lipoprotein
HLY11_17885	COG0656	L-ascorbic acid biosynthetic process
HLY11_17890	COG1979	alcohol dehydrogenase
HLY11_17895	COG2207	Transcriptional regulator
HLY11_17900	COG0586	Pfam SNARE associated Golgi protein
HLY11_17905	COG0626	cystathionine gamma-synthase activity
HLY11_17910	COG0811	peptide transport
HLY11_17915	COG0848	biopolymer transport protein
HLY11_17920	COG1028	Short-chain dehydrogenase reductase Sdr
HLY11_17930	COG0667	Aldo Keto reductase
HLY11_17945	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
HLY11_17950	COG0437	4 iron, 4 sulfur cluster binding
HLY11_17955	COG5557	Pfam Polysulphide reductase, NrfD
HLY11_17960	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
HLY11_17965	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
HLY11_17970	COG1773	rubredoxin
HLY11_17975	COG0375	protein maturation
HLY11_17980	COG0298	carbon dioxide binding
HLY11_17985	COG0625	glutathione transferase activity
HLY11_17990	COG0754	glutathionylspermidine amidase activity
HLY11_17995	COG0306	phosphate transporter
HLY11_18000	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HLY11_18005	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HLY11_18010	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HLY11_18015	COG2244	polysaccharide biosynthetic process
HLY11_18025	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
HLY11_18030	COG0795	lipopolysaccharide-transporting ATPase activity
HLY11_18040	COG0156	8-amino-7-oxononanoate synthase activity
HLY11_18045	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HLY11_18055	COG0318	PFAM AMP-dependent synthetase and ligase
HLY11_18060	COG0456	acetyltransferase
HLY11_18065	COG2186	Transcriptional regulator
HLY11_18070	COG0277	FAD linked oxidase domain protein
HLY11_18075	COG0277	FAD linked oxidase domain protein
HLY11_18080	COG0247	lactate metabolic process
HLY11_18085	COG3193	protein, possibly involved in utilization of glycolate and propanediol
HLY11_18090	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
HLY11_18095	COG1620	l-lactate permease
HLY11_18125	COG1811	Na channel or pump
HLY11_18130	COG1982	Orn Lys Arg decarboxylase major
HLY11_18135	COG2211	Major facilitator Superfamily
HLY11_18150	COG1194	a g-specific adenine glycosylase
HLY11_18160	COG3171	Protein conserved in bacteria
HLY11_18170	COG0252	asparaginase activity
HLY11_18180	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HLY11_18195	COG0762	integral membrane protein
HLY11_18200	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HLY11_18205	COG2805	Type II/IV secretion system protein
HLY11_18220	COG0189	ligase activity
HLY11_18225	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HLY11_18230	COG2356	endonuclease I
HLY11_18240	COG2814	Major facilitator Superfamily
HLY11_18260	COG1166	arginine decarboxylase activity
HLY11_18280	COG0501	Belongs to the peptidase M48B family
HLY11_18285	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HLY11_18290	COG0330	HflC and HflK could
HLY11_18295	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HLY11_18300	COG2213	PTS system mannitol-specific
HLY11_18305	COG1063	alcohol dehydrogenase
HLY11_18310	COG1494	fructose-1,6-bisphosphatase
HLY11_18320	COG1072	(Pantothenic acid kinase))
HLY11_18325	COG1122	ATPase activity
HLY11_18330	COG1122	ATPase activity
HLY11_18360	COG0191	fructose-bisphosphate aldolase activity
HLY11_18365	COG0668	transmembrane transport
HLY11_18370	COG1279	arginine transmembrane transporter activity
HLY11_18375	COG2968	Membrane
HLY11_18380	COG0583	DNA-binding transcription factor activity
HLY11_18385	COG0427	acetyl-CoA hydrolase
HLY11_18390	COG1024	Enoyl-CoA hydratase
HLY11_18395	COG1703	isobutyryl-CoA mutase activity
HLY11_18400	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HLY11_18400	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HLY11_18410	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HLY11_18435	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HLY11_18450	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HLY11_18470	COG0006	proline dipeptidase activity
HLY11_18475	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HLY11_18480	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HLY11_18505	COG2723	6-phospho-beta-galactosidase activity
HLY11_18515	COG1272	protein, Hemolysin III
HLY11_18525	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
HLY11_18535	COG0716	FMN binding
HLY11_18540	COG4974	Belongs to the 'phage' integrase family
HLY11_18545	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HLY11_18550	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HLY11_18560	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HLY11_18580	COG2233	PERMEase
HLY11_18590	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HLY11_18595	COG2252	PERMEase
HLY11_18600	COG0402	S-adenosylhomocysteine deaminase activity
HLY11_18605	COG2233	PERMEase
HLY11_18610	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HLY11_18610	COG2080	2 iron, 2 sulfur cluster binding
HLY11_18615	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
HLY11_18620	COG0402	S-adenosylhomocysteine deaminase activity
HLY11_18625	COG0493	'glutamate synthase
HLY11_18625	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HLY11_18630	COG2068	MobA-Related Protein
HLY11_18635	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HLY11_18640	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
HLY11_18640	COG3608	succinylglutamate desuccinylase aspartoacylase
HLY11_18645	COG0549	Belongs to the carbamate kinase family
HLY11_18655	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HLY11_18660	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HLY11_18665	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HLY11_18675	COG2080	2 iron, 2 sulfur cluster binding
HLY11_18680	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
HLY11_18685	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HLY11_18690	COG4942	peptidase
HLY11_18700	COG3387	PFAM Glycoside hydrolase 15-related
HLY11_18710	COG2207	Transcriptional regulator
HLY11_18815	COG2197	response regulator
HLY11_18820	COG0741	lytic transglycosylase activity
HLY11_18830	COG3710	Transcriptional regulator
HLY11_18830	COG0457	Tetratricopeptide repeat
HLY11_18835	COG0457	Tetratricopeptide repeat
HLY11_18860	COG3710	Transcriptional regulator
HLY11_18865	COG2771	luxR family
HLY11_18870	COG0814	amino acid
HLY11_18875	COG0183	Belongs to the thiolase family
HLY11_18885	COG1028	Short-chain dehydrogenase reductase Sdr
HLY11_18890	COG2814	Major facilitator Superfamily
HLY11_18895	COG1794	racemase activity, acting on amino acids and derivatives
HLY11_18900	COG0583	DNA-binding transcription factor activity
HLY11_18910	COG1609	Transcriptional regulator
HLY11_18925	COG0667	Aldo Keto reductase
HLY11_18935	COG0861	Integral membrane protein TerC family
HLY11_18950	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
HLY11_18965	COG2165	general secretion pathway protein
HLY11_18970	COG4795	General secretion pathway protein
HLY11_18980	COG4967	type IV pilus modification protein PilV
HLY11_18985	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
HLY11_18990	COG1025	Belongs to the peptidase M16 family
HLY11_18995	COG1074	ATP-dependent DNA helicase activity
HLY11_19000	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HLY11_19005	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HLY11_19005	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
HLY11_19010	COG0860	N-Acetylmuramoyl-L-alanine amidase
HLY11_19015	COG3711	transcriptional antiterminator
HLY11_19020	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HLY11_19020	COG1263	PTS System
HLY11_19025	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HLY11_19045	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
HLY11_19050	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HLY11_19055	COG2166	iron-sulfur cluster assembly
HLY11_19060	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HLY11_19070	COG0583	DNA-binding transcription factor activity
HLY11_19075	COG2363	Small membrane protein
HLY11_19085	COG1349	DNA-binding transcription factor activity
HLY11_19095	COG1070	Carbohydrate kinase
HLY11_19105	COG0738	Major facilitator superfamily
HLY11_19110	COG0235	Class ii aldolase
HLY11_19115	COG1454	alcohol dehydrogenase
HLY11_19125	COG1760	l-serine dehydratase
HLY11_19130	COG0814	amino acid
HLY11_19135	COG1611	Belongs to the LOG family
HLY11_19150	COG3098	single-species biofilm formation
HLY11_19155	COG0564	pseudouridine synthase activity
HLY11_19160	COG0716	FMN binding
HLY11_19165	COG2271	Major facilitator Superfamily
HLY11_19170	COG4948	Mandelate Racemase Muconate Lactonizing
HLY11_19175	COG4948	Mandelate Racemase Muconate Lactonizing
HLY11_19180	COG3437	response regulator, receiver
HLY11_19180	COG3850	Histidine kinase
HLY11_19180	COG4999	Histidine kinase
HLY11_19180	COG2205	protein histidine kinase activity
HLY11_19190	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HLY11_19195	COG3956	TIGRFAM MazG family protein
HLY11_19210	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
HLY11_19220	COG0602	queuosine metabolic process
HLY11_19230	COG0720	synthase
HLY11_19260	COG2234	aminopeptidase activity
HLY11_19315	COG1388	LysM domain
HLY11_19315	COG4942	peptidase
HLY11_19320	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HLY11_19330	COG0163	prenyltransferase activity
HLY11_19335	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HLY11_19345	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HLY11_19365	COG3604	Transcriptional regulator
HLY11_19370	COG0309	Hydrogenase expression formation protein (HypE)
HLY11_19375	COG0409	Hydrogenase expression formation protein
HLY11_19380	COG0298	carbon dioxide binding
HLY11_19385	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
HLY11_19390	COG0375	protein maturation
HLY11_19400	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HLY11_19405	COG0651	ATP synthesis coupled electron transport
HLY11_19410	COG0650	Formate hydrogenlyase subunit 4
HLY11_19415	COG3261	NADH dehydrogenase
HLY11_19415	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
HLY11_19420	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HLY11_19425	COG3260	NADH ubiquinone oxidoreductase 20
HLY11_19435	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
HLY11_19440	COG2723	6-phospho-beta-galactosidase activity
HLY11_19445	COG1263	PTS System
HLY11_19445	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HLY11_19450	COG1609	Transcriptional regulator
HLY11_19455	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HLY11_19460	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
HLY11_19485	COG1349	DNA-binding transcription factor activity
HLY11_19490	COG4578	phosphoenolpyruvate-dependent sugar phosphotransferase system
HLY11_19495	COG1028	Short-chain dehydrogenase reductase Sdr
HLY11_19505	COG3732	PTS system glucitol sorbitol-specific
HLY11_19510	COG3730	PTS system glucitol sorbitol-specific
HLY11_19515	COG2951	lytic endotransglycosylase activity
HLY11_19525	COG1546	Belongs to the CinA family
HLY11_19545	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
HLY11_19575	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HLY11_19580	COG1238	metal cluster binding
HLY11_19605	COG2814	Major facilitator Superfamily
HLY11_19610	COG1566	PFAM secretion protein HlyD family protein
HLY11_19615	COG1846	Transcriptional regulator
HLY11_19630	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
HLY11_19635	COG2814	Major facilitator Superfamily
HLY11_19640	COG2113	Glycine betaine
HLY11_19645	COG4176	ABC-type proline glycine betaine transport system permease component
HLY11_19650	COG4175	Glycine betaine
HLY11_19655	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HLY11_19660	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HLY11_19670	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HLY11_19675	COG4575	ribosome binding
HLY11_19690	COG2916	Histone family protein nucleoid-structuring protein H-NS
HLY11_19695	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HLY11_19700	COG0640	Transcriptional regulator
HLY11_19705	COG0401	homolog of Blt101
HLY11_19710	COG1652	LysM domain
HLY11_19715	COG1802	Transcriptional regulator
HLY11_19720	COG1113	amino acid transport
HLY11_19725	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HLY11_19730	COG1012	belongs to the aldehyde dehydrogenase family
HLY11_19735	COG0579	oxidoreductase
HLY11_19770	COG3468	outer membrane autotransporter barrel domain protein
HLY11_19785	COG2867	negative regulation of translational initiation
HLY11_19795	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HLY11_19800	COG0497	DNA recombination
HLY11_19815	COG4536	flavin adenine dinucleotide binding
HLY11_19820	COG4137	Cytochrome C assembly protein
HLY11_19825	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HLY11_19850	COG2885	chlorophyll binding
HLY11_19855	COG2199	diguanylate cyclase activity
HLY11_19870	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HLY11_19875	COG1605	Chorismate mutase
HLY11_19875	COG0287	Prephenate dehydrogenase
HLY11_19880	COG0077	Prephenate dehydratase
HLY11_19880	COG1605	Chorismate mutase
HLY11_19890	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HLY11_19895	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HLY11_19900	COG0564	pseudouridine synthase activity
HLY11_19910	COG0542	response to heat
HLY11_19935	COG0477	Major facilitator Superfamily
HLY11_19940	COG5544	Lipoprotein
HLY11_19945	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HLY11_19950	COG0045	succinate-CoA ligase (ADP-forming) activity
HLY11_19950	COG1042	CoA-binding domain protein
HLY11_19950	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HLY11_19960	COG3118	belongs to the thioredoxin family
HLY11_19965	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HLY11_19985	COG0583	DNA-binding transcription factor activity
HLY11_19990	COG0513	Belongs to the DEAD box helicase family
HLY11_20000	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HLY11_20010	COG1595	DNA-templated transcription, initiation
HLY11_20015	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
HLY11_20020	COG3026	antisigma factor binding
HLY11_20025	COG3086	response to oxidative stress
HLY11_20035	COG0681	Belongs to the peptidase S26 family
HLY11_20055	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
HLY11_20070	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HLY11_20075	COG1737	Transcriptional regulator
HLY11_20080	COG0560	Phosphoserine phosphatase
HLY11_20095	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HLY11_20095	COG0047	phosphoribosylformylglycinamidine synthase activity
HLY11_20100	COG2205	protein histidine kinase activity
HLY11_20105	COG3170	Tfp pilus assembly protein FimV
HLY11_20110	COG2204	response regulator
HLY11_20115	COG0347	Belongs to the P(II) protein family
HLY11_20120	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HLY11_20120	COG1017	nitric oxide dioxygenase activity
HLY11_20130	COG1940	carbohydrate kinase activity
HLY11_20135	COG0457	Tetratricopeptide repeat
HLY11_20140	COG1879	ABC-type sugar transport system periplasmic component
HLY11_20145	COG1129	ABC transporter
HLY11_20150	COG1172	Belongs to the binding-protein-dependent transport system permease family
HLY11_20155	COG1063	alcohol dehydrogenase
HLY11_20160	COG2017	converts alpha-aldose to the beta-anomer
HLY11_20165	COG2259	Doxx family
HLY11_20190	COG4638	Rieske (2fe-2S)
HLY11_20195	COG0583	DNA-binding transcription factor activity
HLY11_20200	COG2814	Major facilitator Superfamily
HLY11_20205	COG3711	transcriptional antiterminator
HLY11_20210	COG1073	alpha beta
HLY11_20215	COG0483	inositol monophosphate 1-phosphatase activity
HLY11_20235	COG0822	iron-sulfur transferase activity
HLY11_20255	COG0633	Ferredoxin
HLY11_20260	COG2975	iron-sulfur cluster assembly
HLY11_20285	COG2897	thiosulfate sulfurtransferase activity
HLY11_20290	COG2373	Large extracellular alpha-helical protein
HLY11_20295	COG4953	penicillin-binding protein 1C
HLY11_20325	COG2976	Protein conserved in bacteria
HLY11_20340	COG1645	bacterial-type flagellum-dependent swarming motility
HLY11_20365	COG0517	IMP dehydrogenase activity
HLY11_20365	COG0516	GMP reductase activity
HLY11_20380	COG3133	Outer membrane lipoprotein
HLY11_20395	COG2200	EAL domain
HLY11_20400	COG0248	Ppx GppA phosphatase
HLY11_20405	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
HLY11_20410	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HLY11_20425	COG2233	PERMEase
HLY11_20435	COG1393	Belongs to the ArsC family
HLY11_20440	COG4783	chaperone-mediated protein folding
HLY11_20445	COG0628	permease
HLY11_20450	COG2116	formate transmembrane transporter activity
HLY11_20455	COG3604	Transcriptional regulator
HLY11_20465	COG3260	NADH ubiquinone oxidoreductase 20
HLY11_20470	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HLY11_20475	COG3261	NADH dehydrogenase
HLY11_20475	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
HLY11_20480	COG0651	ATP synthesis coupled electron transport
HLY11_20485	COG4237	Hydrogenase 4 membrane
HLY11_20490	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HLY11_20495	COG0650	Formate hydrogenlyase subunit 4
HLY11_20500	COG0651	ATP synthesis coupled electron transport
HLY11_20505	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HLY11_20510	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HLY11_20515	COG2716	regulation of RNA biosynthetic process
HLY11_20525	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
HLY11_20535	COG2321	neutral zinc metallopeptidase
HLY11_20540	COG1444	tRNA N-acetyltransferase activity
HLY11_20545	COG0400	carboxylic ester hydrolase activity
HLY11_20560	COG1393	Belongs to the ArsC family
HLY11_20570	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HLY11_20575	COG3850	Histidine kinase
HLY11_20580	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HLY11_20580	COG0493	'glutamate synthase
HLY11_20590	COG5342	invasion associated locus B
HLY11_20595	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HLY11_20600	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HLY11_20605	COG0281	malic enzyme
HLY11_20605	COG0280	phosphate acetyltransferase
HLY11_20610	COG4810	utilization protein
HLY11_20615	COG4917	ethanolamine utilization protein
HLY11_20620	COG4766	ethanolamine catabolic process
HLY11_20625	COG4812	Cobalamin adenosyltransferase
HLY11_20630	COG0280	phosphate acetyltransferase
HLY11_20635	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
HLY11_20640	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
HLY11_20645	COG1012	belongs to the aldehyde dehydrogenase family
HLY11_20650	COG4820	ethanolamine utilization protein (EutJ)
HLY11_20655	COG1454	alcohol dehydrogenase
HLY11_20660	COG3192	ethanolamine utilization protein
HLY11_20665	COG4819	ethanolamine utilization protein
HLY11_20670	COG4303	Ethanolamine ammonia lyase large subunit
HLY11_20680	COG4816	utilization protein
HLY11_20685	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
HLY11_20690	COG2207	Transcriptional regulator
HLY11_20700	COG0860	N-Acetylmuramoyl-L-alanine amidase
HLY11_20720	COG2837	iron assimilation
HLY11_20725	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HLY11_20730	COG1263	PTS System
HLY11_20730	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HLY11_20745	COG1028	Short-chain dehydrogenase reductase Sdr
HLY11_20750	COG4150	thiosulfate binding
HLY11_20755	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
HLY11_20760	COG4208	sulfate ABC transporter
HLY11_20765	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
HLY11_20770	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HLY11_20780	COG4884	unkown
HLY11_20780	COG3831	ATPase activity
HLY11_20795	COG2190	(PTS) system
HLY11_20800	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HLY11_20805	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HLY11_20810	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HLY11_20830	COG3530	Putative quorum-sensing-regulated virulence factor
HLY11_20835	COG0385	Bile acid
HLY11_20840	COG2211	Major facilitator Superfamily
HLY11_20850	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
HLY11_20855	COG2211	Major facilitator Superfamily
HLY11_20860	COG0583	DNA-binding transcription factor activity
HLY11_20885	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HLY11_20890	COG3415	Transposase
HLY11_20895	COG3415	Transposase
HLY11_20910	COG2199	diguanylate cyclase activity
HLY11_20910	COG2200	EAL domain
HLY11_20915	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HLY11_20940	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HLY11_20945	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HLY11_20950	COG0006	proline dipeptidase activity
HLY11_20955	COG1363	Peptidase, m42
HLY11_20965	COG2207	Transcriptional regulator
HLY11_20970	COG3279	Response regulator of the LytR AlgR family
HLY11_20975	COG3275	phosphorelay sensor kinase activity
HLY11_20980	COG0436	Aminotransferase
HLY11_20990	COG1560	Kdo2-lipid A biosynthetic process
HLY11_21015	COG0028	Belongs to the TPP enzyme family
HLY11_21020	COG0679	Auxin Efflux Carrier
HLY11_21025	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HLY11_21030	COG2205	protein histidine kinase activity
HLY11_21030	COG2198	Histidine kinase
HLY11_21030	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HLY11_21030	COG0784	Response regulator, receiver
HLY11_21035	COG2197	response regulator
HLY11_21040	COG1566	PFAM secretion protein HlyD family protein
HLY11_21045	COG0477	Major facilitator Superfamily
HLY11_21055	COG2610	gluconate transmembrane transporter activity
HLY11_21060	COG0583	DNA-binding transcription factor activity
HLY11_21070	COG2116	formate transmembrane transporter activity
HLY11_21075	COG2853	Lipoprotein
HLY11_21085	COG2067	long-chain fatty acid transport protein
HLY11_21090	COG3691	Protein conserved in bacteria
HLY11_21105	COG2062	phosphohistidine phosphatase, SixA
HLY11_21110	COG3539	Fimbrial protein
HLY11_21115	COG3188	usher protein
HLY11_21120	COG3121	Chaperone
HLY11_21125	COG3539	Fimbrial protein
HLY11_21130	COG3539	Fimbrial protein
HLY11_21135	COG3539	Fimbrial protein
HLY11_21150	COG2890	protein-(glutamine-N5) methyltransferase activity
HLY11_21165	COG0730	response to heat
HLY11_21170	COG3101	peptidyl-lysine hydroxylation
HLY11_21190	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HLY11_21195	COG2814	Major facilitator Superfamily
HLY11_21210	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HLY11_21220	COG0586	Pfam SNARE associated Golgi protein
HLY11_21230	COG0285	dihydrofolate synthase activity
HLY11_21235	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
HLY11_21240	COG1286	toxin biosynthetic process
HLY11_21245	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HLY11_21250	COG0163	prenyltransferase activity
HLY11_21255	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HLY11_21260	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HLY11_21265	COG4215	(ABC) transporter
HLY11_21270	COG4160	amino acid transport
HLY11_21275	COG4598	ABC transporter
HLY11_21280	COG5464	transposase or invertase
HLY11_21285	COG1090	epimerase
HLY11_21290	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HLY11_21295	COG0625	glutathione transferase activity
HLY11_21300	COG0625	glutathione transferase activity
HLY11_21305	COG0622	Phosphoesterase
HLY11_21310	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
HLY11_21315	COG1288	antiporter activity
HLY11_21320	COG0857	belongs to the CobB CobQ family
HLY11_21320	COG0280	phosphate acetyltransferase
HLY11_21325	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HLY11_21340	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HLY11_21345	COG0490	domain, Protein
HLY11_21345	COG0471	metal ion transport
HLY11_21355	COG0436	Aminotransferase
HLY11_21360	COG0583	DNA-binding transcription factor activity
HLY11_21380	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
HLY11_21385	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
HLY11_21390	COG1034	ATP synthesis coupled electron transport
HLY11_21405	COG0839	Belongs to the complex I subunit 6 family
HLY11_21415	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HLY11_21420	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HLY11_21435	COG2234	aminopeptidase activity
HLY11_21440	COG2304	oxidoreductase activity
HLY11_21455	COG2153	protein acetylation
HLY11_21460	COG4575	ribosome binding
HLY11_21465	COG1169	isochorismate synthase
HLY11_21480	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
HLY11_21490	COG0318	PFAM AMP-dependent synthetase and ligase
HLY11_21555	COG1414	Transcriptional regulator
HLY11_21565	COG2271	Major facilitator Superfamily
HLY11_21570	COG3836	Belongs to the HpcH HpaI aldolase family
HLY11_21580	COG5464	transposase or invertase
HLY11_21585	COG0247	lactate metabolic process
HLY11_21595	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HLY11_21600	COG2271	Major facilitator Superfamily
HLY11_21605	COG0584	glycerophosphoryl diester phosphodiesterase
HLY11_21610	COG0583	DNA-binding transcription factor activity
HLY11_21615	COG2814	Major facilitator Superfamily
HLY11_21620	COG3642	lipopolysaccharide core region biosynthetic process
HLY11_21625	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HLY11_21630	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HLY11_21635	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HLY11_21640	COG3468	outer membrane autotransporter barrel domain protein
HLY11_21650	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HLY11_21655	COG4685	Uncharacterized protein conserved in bacteria (DUF2138)
HLY11_21660	COG3234	Protein of unknown function (DUF1175)
HLY11_21665	COG2373	Large extracellular alpha-helical protein
HLY11_21670	COG5445	Predicted secreted protein (DUF2300)
HLY11_21675	COG4676	Protein conserved in bacteria
HLY11_21680	COG0784	Response regulator, receiver
HLY11_21680	COG2205	protein histidine kinase activity
HLY11_21685	COG2197	response regulator
HLY11_21690	COG2198	Histidine kinase
HLY11_21690	COG0642	Histidine kinase
HLY11_21695	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HLY11_21700	COG1477	protein flavinylation
HLY11_21705	COG2169	Transcriptional regulator
HLY11_21705	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HLY11_21710	COG3145	DNA-N1-methyladenine dioxygenase activity
HLY11_21715	COG4615	Cyclic peptide transporter
HLY11_21730	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
HLY11_21730	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HLY11_21735	COG3062	negative regulation of establishment of protein localization
HLY11_21745	COG0437	4 iron, 4 sulfur cluster binding
HLY11_21750	COG0348	domain, Protein
HLY11_21755	COG3043	anaerobic respiration
HLY11_21760	COG3005	denitrification pathway
HLY11_21765	COG4133	protoheme IX ABC transporter activity
HLY11_21770	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HLY11_21775	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HLY11_21780	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HLY11_21790	COG1138	Cytochrome C-type biogenesis protein
HLY11_21795	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HLY11_21800	COG3088	subunit of a heme lyase
HLY11_21800	COG4235	cytochrome complex assembly
HLY11_21805	COG2197	response regulator
HLY11_21810	COG3468	outer membrane autotransporter barrel domain protein
HLY11_21820	COG3083	sulfuric ester hydrolase activity
HLY11_21835	COG3005	denitrification pathway
HLY11_21840	COG1053	succinate dehydrogenase
HLY11_21840	COG0431	NADPH-dependent FMN reductase
HLY11_21840	COG3976	FMN-binding domain protein
HLY11_21855	COG1061	Type III restriction enzyme res subunit
HLY11_21860	COG1187	pseudouridine synthase activity
HLY11_21865	COG2814	Major facilitator Superfamily
HLY11_21875	COG4172	Belongs to the ABC transporter superfamily
HLY11_21880	COG4239	(ABC) transporter, permease
HLY11_21885	COG4174	ABC transporter (Permease)
HLY11_21890	COG4166	transmembrane transport
HLY11_21895	COG2200	EAL domain
HLY11_21900	COG0791	NLP P60 protein
HLY11_21905	COG0671	phosphoesterase, PA-phosphatase related
HLY11_21910	COG0523	cobalamin synthesis protein
HLY11_21915	COG0246	Mannitol dehydrogenase
HLY11_21930	COG2814	Major facilitator Superfamily
HLY11_21935	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HLY11_21935	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HLY11_21940	COG1105	Belongs to the carbohydrate kinase PfkB family
HLY11_21945	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HLY11_21945	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HLY11_21945	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
HLY11_21950	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HLY11_21955	COG2313	pseudouridylate synthase activity
HLY11_21960	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HLY11_21965	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HLY11_21975	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HLY11_21980	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HLY11_21980	COG1522	sequence-specific DNA binding
HLY11_21990	COG2855	membrane
HLY11_21995	COG0583	DNA-binding transcription factor activity
HLY11_22000	COG0833	amino acid
HLY11_22005	COG4771	TonB-dependent receptor
HLY11_22015	COG0560	Phosphoserine phosphatase
HLY11_22020	COG1760	l-serine dehydratase
HLY11_22040	COG2311	Membrane
HLY11_22045	COG1609	Transcriptional regulator
HLY11_22050	COG1879	ABC-type sugar transport system periplasmic component
HLY11_22055	COG1129	ABC transporter
HLY11_22060	COG4211	Belongs to the binding-protein-dependent transport system permease family
HLY11_22065	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
HLY11_22065	COG0167	dihydroorotate dehydrogenase activity
HLY11_22070	COG0493	'glutamate synthase
HLY11_22080	COG2949	membrane
HLY11_22090	COG1346	cytolysis
HLY11_22100	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HLY11_22115	COG1028	Short-chain dehydrogenase reductase Sdr
HLY11_22120	COG0586	Pfam SNARE associated Golgi protein
HLY11_22130	COG1686	Belongs to the peptidase S11 family
HLY11_22135	COG0277	FAD linked oxidase domain protein
HLY11_22140	COG1472	Belongs to the glycosyl hydrolase 3 family
HLY11_22145	COG1732	Glycine betaine
HLY11_22150	COG1174	glycine betaine transport
HLY11_22155	COG1125	glycine betaine transport
HLY11_22160	COG1174	glycine betaine transport
HLY11_22170	COG0789	Transcriptional regulator
HLY11_22175	COG3275	phosphorelay sensor kinase activity
HLY11_22180	COG3279	Response regulator of the LytR AlgR family
HLY11_22185	COG4807	Protein conserved in bacteria
HLY11_22190	COG4808	Protein conserved in bacteria
HLY11_22195	COG4715	Zinc finger, swim domain protein
HLY11_22200	COG3552	Protein containing von Willebrand factor type A (VWA) domain
HLY11_22205	COG2425	protein containing a von Willebrand factor type A (vWA) domain
HLY11_22210	COG0714	Associated with various cellular activities
HLY11_22220	COG3831	ATPase activity
HLY11_22225	COG3831	ATPase activity
HLY11_22230	COG3831	ATPase activity
HLY11_22235	COG3831	ATPase activity
HLY11_22240	COG3831	ATPase activity
HLY11_22250	COG0489	protein tyrosine kinase activity
HLY11_22260	COG3539	Fimbrial protein
HLY11_22265	COG3121	Chaperone
HLY11_22270	COG3188	usher protein
HLY11_22275	COG3539	Fimbrial protein
HLY11_22280	COG5455	response to cobalt ion
HLY11_22300	COG0351	phosphomethylpyrimidine kinase
HLY11_22305	COG3757	hydrolase, family 25
HLY11_22310	COG2188	Transcriptional regulator
HLY11_22315	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HLY11_22320	COG1397	ADP-ribosylglycohydrolase
HLY11_22325	COG2211	Major facilitator Superfamily
HLY11_22330	COG1830	Aldolase
HLY11_22340	COG1069	ribulokinase activity
HLY11_22365	COG1070	Carbohydrate kinase
HLY11_22375	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HLY11_22390	COG4974	Belongs to the 'phage' integrase family