locus-tag class description FE384_00010 ENOG4105CFH Aspartokinase FE384_00020 ENOG4105D98 threonine synthase FE384_00025 ENOG41062C6 Protein of unknown function (DUF2502) FE384_00035 ENOG4105BZG amino acid carrier protein FE384_00045 ENOG4108RIR Molybdenum cofactor biosynthesis protein FE384_00050 ENOG4106HK8 GPR1 FUN34 yaaH family protein FE384_00055 ENOG4108QUJ UPF0174 protein YaaW FE384_00070 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) FE384_00075 ENOG4108SER Transposase FE384_00080 ENOG4105WI6 cell killing protein encoded within cryptic prophage FE384_00085 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) FE384_00090 ENOG41063Z6 transcriptional regulator, lysR family FE384_00105 ENOG410647N response to DNA damage stimulus FE384_00110 ENOG4105DTN riboflavin biosynthesis protein ribF FE384_00125 ENOG41090X3 Peptidyl-prolyl cis-trans isomerase FE384_00145 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain FE384_00150 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain FE384_00155 ENOG4108XNW Transcriptional activatory protein CaiF FE384_00165 ENOG4106YT9 Enoyl-CoA hydratase FE384_00200 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase FE384_00205 ENOG4105IBM Could be part of an electron transfer system required for anaerobic carnitine reduction. Could be a 3Fe-4S cluster- containing protein FE384_00210 ENOG4105C54 Major Facilitator superfamily FE384_00225 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) FE384_00250 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) FE384_00255 ENOG4105E7H involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity) FE384_00260 ENOG41066UG Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host (By similarity) FE384_00275 ENOG4105D3G Pseudouridine synthase FE384_00285 ENOG4105CQ2 DNA polymerase FE384_00290 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase FE384_00295 ENOG4105CAC Catalyzes the conversion of L-arabinose to L-ribulose (By similarity) FE384_00300 ENOG4105EF1 ribulokinase FE384_00305 ENOG41063TF transcriptional regulator (AraC FE384_00310 ENOG4108KF1 Membrane FE384_00315 ENOG4107T0D ABC, transporter FE384_00320 ENOG4106SMU thiamine transporter membrane protein FE384_00325 ENOG4105DP9 ABC transporter FE384_00330 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) FE384_00340 ENOG4105S8Q sugar efflux transporter FE384_00355 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) FE384_00370 ENOG41064T2 transcriptional regulator, lysR family FE384_00380 ENOG4105C7K acetolactate synthase FE384_00385 ENOG4108ZP8 Acetolactate synthase small subunit FE384_00395 ENOG4107B7Y DNA-binding transcriptional regulator FruR FE384_00400 ENOG4108V6E Cell division protein mraZ FE384_00410 ENOG41063Y6 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) FE384_00415 ENOG4105CJN penicillin-binding protein FE384_00420 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) FE384_00425 ENOG4108EQQ Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity) FE384_00435 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) FE384_00440 ENOG4105CNI cell division protein FtsW FE384_00455 ENOG4105CPF Cell wall formation (By similarity) FE384_00460 ENOG4105K7E Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity) FE384_00465 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) FE384_00470 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) FE384_00490 ENOG4105M6F mutator MutT protein FE384_00505 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) FE384_00515 ENOG4105D7Q type ii secretion system FE384_00520 ENOG4107QHF type ii secretion system protein e FE384_00525 ENOG4108ZUW Major pilin subunit FE384_00530 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase FE384_00535 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase FE384_00540 ENOG4106A72 regulatory protein AmpE FE384_00545 ENOG4105C85 amino acid FE384_00550 ENOG41073TP transcriptional regulator FE384_00555 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) FE384_00560 ENOG4107QSN dihydrolipoamide acetyltransferase FE384_00565 ENOG4107QN2 dihydrolipoyl dehydrogenase FE384_00570 ENOG4108NST exported protein FE384_00575 ENOG4107QIJ Aconitate hydratase 2 FE384_00595 ENOG4108ZRK uncharacterized protein yacC FE384_00600 ENOG4105E3B Multicopper oxidase FE384_00605 ENOG4105DZG Dehydrogenase FE384_00610 ENOG4108UGV hypoxanthine phosphoribosyltransferase FE384_00615 ENOG41077A9 carbonic anhydrase FE384_00620 ENOG4105DA5 (ABC) transporter FE384_00625 ENOG4105E3A (ABC) transporter FE384_00630 ENOG4108YTN IIa component FE384_00635 ENOG4107BJW polysaccharide deacetylase FE384_00645 ENOG4108A32 Transposase FE384_00660 ENOG4105P0Q fimbrial-like protein YadC FE384_00665 ENOG4105SN2 fimbrial-like adhesin protein FE384_00670 ENOG4105SYG Fimbrial protein FE384_00675 ENOG4108XEY fimbrial-like adhesin protein FE384_00680 ENOG4105CW0 outer membrane usher protein FE384_00685 ENOG4108VEV chaperone FE384_00695 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase FE384_00700 ENOG4105DJ0 Poly(A) Polymerase FE384_00710 ENOG4108V7X Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters FE384_00720 ENOG4107XID 2'-5' rna ligase FE384_00725 ENOG4105CQ7 ATP-dependent helicase FE384_00730 ENOG4105BZ4 penicillin-binding protein FE384_00735 ENOG4105E0K tonB-dependent siderophore receptor FE384_00740 ENOG4105E0A ABC, transporter FE384_00745 ENOG4105J76 Periplasmic binding protein FE384_00750 ENOG4105S6R Iron-hydroxamate transporter permease subunit FE384_00775 ENOG4105EN6 Membrane FE384_00780 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) FE384_00795 ENOG4105C0H protease FE384_00800 ENOG4108IXP Carbohydrate diacid transcriptional activator CdaR FE384_00815 ENOG4105DIN metallophosphoesterase FE384_00830 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) FE384_00855 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) FE384_00860 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) FE384_00865 ENOG4105KNE Phosphatidate cytidylyltransferase FE384_00870 ENOG4105DZP Membrane-associated zinc metalloprotease FE384_00880 ENOG4108RFI Molecular chaperone that interacts specifically with outer membrane proteins, thus maintaining the solubility of early folding intermediates during passage through the periplasm (By similarity) FE384_00885 ENOG4105D7M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) FE384_00910 ENOG4105C0B DNA polymerase III (alpha subunit) FE384_00920 ENOG4105CXN decarboxylase FE384_00925 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase FE384_00930 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) FE384_00935 ENOG4105M1T rho-binding antiterminator FE384_00945 ENOG4108VWS Yaeq family FE384_00950 ENOG4108YZN class I peptide chain release factor FE384_00955 ENOG4107EII Lipoprotein involved with copper homeostasis and adhesion FE384_00960 ENOG4108UY0 (LipO)protein FE384_00970 ENOG4108R96 Methyltransferase, YaeB family FE384_00975 ENOG4108R8X outer membrane lipoprotein FE384_00980 ENOG4105D01 (LipO)protein FE384_00985 ENOG4108UMI ABC transporter, permease FE384_00990 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) FE384_00995 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase FE384_01030 ENOG4105CV8 reductase FE384_01035 ENOG4105HEI LysR family (Transcriptional regulator FE384_01045 ENOG4105F2W methyltransferase FE384_01050 ENOG4105E9H Lytic Murein transglycosylase FE384_01055 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) FE384_01060 ENOG4105D1A Methyltransferase FE384_01070 ENOG4107RZZ dna polymerase iii epsilon subunit FE384_01080 ENOG410600K aminopeptidase FE384_01100 ENOG4105CZ7 nitrilase cyanide hydratase and apolipoprotein n-acyltransferase FE384_01105 ENOG4108WN0 inhibitor of vertebrate lysozyme FE384_01110 ENOG4107QPN acyl-Coa dehydrogenase FE384_01120 ENOG4105E7A Glutamine amidotransferase FE384_01125 ENOG4105F7V ErfK ybiS ycfS ynhG family protein FE384_01130 ENOG4105VXN addiction module toxin, RelE StbE family FE384_01135 ENOG4105QHH Antitoxin component of a toxin-antitoxin (TA) module. A labile antitoxin that counteracts the effect of the YafQ toxin. YafQ and DinJ together bind their own promoter, and by analogy to other TA modules probably repress its expression FE384_01140 ENOG4108YS0 lipoprotein YafL FE384_01145 ENOG4108UK5 Transposase FE384_01160 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) FE384_01165 ENOG4105UG9 Antitoxin of the YafO-YafN toxin-antitoxin system FE384_01170 ENOG41065DM this blockage is overcome by subsequent expression of antitoxin YafN. Overexpression causes cleavage of a number of mRNAs in a ribosome-dependent fashion. YafO binding to the 50S ribosomal subunit in the translation complex induces mRNA cleavage 3' to the region protected by the ribosome FE384_01175 ENOG4108HYG acetyltransferase FE384_01185 ENOG4108S2Y peptide Chain Release factor FE384_01190 ENOG4105CIN aminoacyl-histidine dipeptidase FE384_01220 ENOG4105FCK Membrane FE384_01240 ENOG4108X3P Toxic component of a toxin-antitoxin (TA) module. Overexpression results in inhibition of growth in liquid cultures FE384_01250 ENOG4105ZS6 Protein of unknown function (DUF987) FE384_01255 ENOG4108XS9 dna repair protein FE384_01260 ENOG4106549 Antirestriction protein FE384_01265 ENOG4106ZN7 UPF0401 protein YkfF FE384_01270 ENOG4106J9S Prophage FE384_01290 ENOG4106H6R UPF0380 protein FE384_01295 ENOG4108MXD gtp-binding protein FE384_01300 ENOG4108PZW LysR family Transcriptional regulator FE384_01315 ENOG4105F9F transposase FE384_01335 ENOG4105F2I Transposase FE384_01340 ENOG4108IQI permease FE384_01345 ENOG4107QK5 Homocysteine s-methyltransferase FE384_01350 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FE384_01375 ENOG4105JXR Protein of unknown function (DUF3296) FE384_01380 ENOG410693A DNA-binding protein FE384_01385 ENOG4106GND FE384_01395 ENOG410792U CP4-6 prophage FE384_01400 ENOG41067CV Integrase FE384_01415 ENOG4107XAN XdhC and CoxI family FE384_01420 ENOG4105C7W Xanthine dehydrogenase FE384_01425 ENOG4105DIP Molybdopterin dehydrogenase FAD-binding FE384_01430 ENOG4107XKX isoquinoline 1-oxidoreductase, alpha subunit FE384_01435 ENOG4105R3P Inner membrane protein yagU FE384_01440 ENOG4105PI0 Ferredoxin FE384_01450 ENOG4106PYX Receptor FE384_01455 ENOG4108N3D putative enzyme FE384_01465 ENOG4108GWT fimbrillin MatB FE384_01470 ENOG4106JB4 Represses expression of the flagellar master operon flhDC, and consequently prevents flagellum biosynthesis and motility. Acts by binding to the regulatory region of the flhDC operon FE384_01485 ENOG4105NRA 50s ribosomal protein l31 type b FE384_01520 ENOG4108KBJ Inner membrane protein YkgB FE384_01525 ENOG41066GK UPF0379 protein ykgI FE384_01530 ENOG4107QN2 dihydrolipoyl dehydrogenase FE384_01535 ENOG4108K01 transcriptional regulator FE384_01540 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) FE384_01545 ENOG4107QR9 Iron-sulfur cluster binding protein FE384_01550 ENOG4108ZZK Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source (By similarity) FE384_01560 ENOG4105CZ6 Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine (By similarity) FE384_01565 ENOG4105C26 Dehydrogenase FE384_01570 ENOG4108MHR Repressor involved in choline regulation of the bet genes (By similarity) FE384_01575 ENOG4105C94 Transporter FE384_01585 ENOG4105BZU Histidine kinase FE384_01590 ENOG4108NUU Transcriptional regulator FE384_01595 ENOG4105SZ2 membrAne FE384_01600 ENOG4107SNB ankyrin repeat protein YahD FE384_01605 ENOG4105N16 Protein of unknown function (DUF2877) FE384_01610 ENOG4107R1Q Membrane protein FdrA FE384_01615 ENOG4107REC cytoplasmic protein FE384_01625 ENOG4105C5B carbamate kinase FE384_01630 ENOG4105DZC cytosine deaminase FE384_01635 ENOG4105DQ4 alcohol dehydrogenase FE384_01650 ENOG4105E82 cytochrome subunit of dehydrogenase FE384_01655 ENOG4105TDT uncharacterized protein yahO FE384_01660 ENOG4108JU7 Transcriptional regulator FE384_01665 ENOG4105CR4 methylisocitrate lyase FE384_01670 ENOG4105BZN citrate synthase FE384_01675 ENOG4105DXD 2-methylcitrate dehydratase FE384_01680 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) FE384_01685 ENOG4105DQW permease for cytosine purines, uracil, thiamine, allantoin FE384_01690 ENOG4105DZC cytosine deaminase FE384_01695 ENOG4105DND Transcriptional regulator FE384_01700 ENOG4107B2H carbonic anhydrase FE384_01705 ENOG4108V7B Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide (By similarity) FE384_01710 ENOG4105DJ2 Major Facilitator Superfamily FE384_01715 ENOG4108UW5 maltose o-acetyltransferase FE384_01720 ENOG4105U0F oligosaccharide H symporter, major facilitator superfamily (MFS) FE384_01725 ENOG4105CNT hydrolase family 2 FE384_01730 ENOG4105ETE Transcriptional regulator (LacI family FE384_01735 ENOG4108K2P TRANSCRIPTIONal FE384_01740 ENOG4105E2Q 3-(3-hydroxy-phenyl)propionate hydroxylase FE384_01745 ENOG4105MI0 Catalyzes the non-heme iron(II)-dependent oxidative cleavage of 2,3-dihydroxyphenylpropionic acid and 2,3- dihydroxicinnamic acid into 2-hydroxy-6-ketononadienedioate and 2- hydroxy-6-ketononatrienedioate, respectively (By similarity) FE384_01750 ENOG4106HB6 Alpha beta hydrolase FE384_01755 ENOG4105IKQ hydratase FE384_01770 ENOG4108SC4 )-transporter FE384_01775 ENOG4105IUQ nucleoprotein polynucleotide-associated enzyme FE384_01780 ENOG4105C4W S-formylglutathione hydrolase FE384_01795 ENOG4105SRB Uncharacterized protein yaiO FE384_01815 ENOG4108PBI Polysaccharide metabolism FE384_01825 ENOG4107W19 lmbE family FE384_01830 ENOG4106FTQ Taurine ABC transporter, periplasmic FE384_01835 ENOG4108IY8 ABC, transporter FE384_01840 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component FE384_01845 ENOG4105E2B Taurine dioxygenase FE384_01850 ENOG4105D52 delta-aminolevulinic acid dehydratase FE384_01870 ENOG4108PNB DNA-binding transcriptional regulator FE384_01875 ENOG4107R6D beta-lactam binding protein AmpH FE384_01880 ENOG4108DQG in Escherichia coli SbmA is involved in uptake of microcin J25 FE384_01885 ENOG4107QS8 (LipO)protein FE384_01890 ENOG4105FR5 inner membrane protein YaiY FE384_01895 ENOG4105UNH Membrane FE384_01900 ENOG4105CPF Cell wall formation (By similarity) FE384_01910 ENOG4105G6Z alkaline phosphatase FE384_01915 ENOG4105VIF phosphate starvation-inducible protein FE384_01920 ENOG4105BZU Histidine kinase FE384_01925 ENOG4105II7 pyrroline-5-carboxylate reductase FE384_01940 ENOG4105SS3 FE384_01945 ENOG4105HBA AroM protein FE384_01970 ENOG4105DKQ ROK family FE384_01975 ENOG4105F27 Major Facilitator FE384_01980 ENOG4105EYH Exonuclease FE384_01985 ENOG4107RH8 nuclease SbcCD subunit D FE384_01990 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FE384_01995 ENOG4105BZU Histidine kinase FE384_02000 ENOG4105CWM branched-chain amino acid transport system II carrier protein FE384_02005 ENOG4105C85 amino acid FE384_02010 ENOG4107R28 alpha amylase, catalytic region FE384_02030 ENOG4105VIE preprotein translocase, subunit YajC FE384_02035 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) FE384_02040 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) FE384_02045 ENOG4105N1F Hnh endonuclease FE384_02050 ENOG4105DRB nucleoside-specific channel-forming protein FE384_02055 ENOG4108KIC (LipO)protein FE384_02065 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) FE384_02070 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) FE384_02080 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) FE384_02085 ENOG4108ZAI phosphatidylglycerophosphatase a FE384_02090 ENOG4105CPC Aldo Keto reductase FE384_02100 ENOG4105CTB Polyprenyl synthetase FE384_02115 ENOG4107S0N DJ-1 family FE384_02120 ENOG4108JZF Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) FE384_02130 ENOG4107RDB Major Facilitator FE384_02140 ENOG41090KH cytochrome o ubiquinol oxidase (subunit iv) FE384_02145 ENOG4105CCU oxidase (Subunit III) FE384_02150 ENOG4105BZ9 Cytochrome C oxidase, subunit I FE384_02155 ENOG4105E2S oxidase) subunit II FE384_02160 ENOG4105EYM Major Facilitator superfamily FE384_02165 ENOG4105IEY (LipO)protein FE384_02170 ENOG4105M85 Bola protein FE384_02190 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) FE384_02195 ENOG4105K70 DNA-binding protein FE384_02200 ENOG4105EIN peptidylprolyl cis-trans isomerase FE384_02205 ENOG41083P1 competence protein ComEA helix-hairpin-helix repeat protein FE384_02210 ENOG4108TGP Thioesterase superfamily protein FE384_02220 ENOG4108NFA extracellular solute-binding protein FE384_02230 ENOG4108XM1 transcriptional regulator AsnC family FE384_02235 ENOG4105BZ1 (ABC) transporter FE384_02240 ENOG4105BZ1 (ABC) transporter FE384_02245 ENOG4108YZA Nitrogen regulatory protein pii FE384_02250 ENOG4105BZU Histidine kinase FE384_02255 ENOG4105C29 acyl-CoA thioesterase FE384_02260 ENOG4108MNP Glycoprotein polysaccharide metabolism FE384_02265 ENOG41080UX Methyltransferase FE384_02275 ENOG4105KCV RNA signal recognition particle 4.5S RNA FE384_02280 ENOG41066DG (EAL) domain protein FE384_02285 ENOG4105GSJ Inner membrane protein ylaC FE384_02290 ENOG4108UW5 maltose o-acetyltransferase FE384_02295 ENOG4105KF5 hemolysin expression-modulating protein FE384_02300 ENOG4108UKR Biofilm formation regulator YbaJ FE384_02305 ENOG4105BZS acriflavin resistance protein FE384_02310 ENOG4105C1P efflux transporter, rnd family, mfp subunit FE384_02315 ENOG4108IG5 Transcriptional regulator FE384_02320 ENOG4105EGS Mechanosensitive ion channel FE384_02325 ENOG4106428 Protein of unknown function (DUF2496) FE384_02330 ENOG4108URS primosomal replication protein n'' FE384_02335 ENOG4105WD1 Membrane FE384_02345 ENOG4107QMP dna polymerase iii subunits gamma and tau FE384_02360 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) FE384_02385 ENOG4107RE1 Inosine-guanosine kinase FE384_02390 ENOG4105CKD glutathione-regulated potassium-efflux system protein FE384_02395 ENOG4105EU0 Major facilitator Superfamily FE384_02400 ENOG4105CGH 5'-nucleotidase FE384_02405 ENOG4108Z66 YbaK ebsC protein FE384_02410 ENOG4105MBR gumn family FE384_02420 ENOG41081XE plasmid maintenance system antidote protein, xre family FE384_02425 ENOG4105C59 p-type ATPase FE384_02430 ENOG4105CSV Glutaminase FE384_02435 ENOG4107RY6 amino acid FE384_02440 ENOG4108Z6Z Transcriptional regulator FE384_02445 ENOG4105G5H Membrane FE384_02450 ENOG4107QX8 SPFH domain, Band 7 family protein FE384_02455 ENOG41083J0 (ABC) transporter FE384_02460 ENOG4105C4B ABC transporter, permease FE384_02465 ENOG4107QR8 Thioredoxin FE384_02470 ENOG4105E1F short-chain dehydrogenase reductase FE384_02475 ENOG4108UJV acyl-CoA thioesterase i FE384_02480 ENOG4108I0Y (ABC) transporter FE384_02485 ENOG4105CV6 ABC transporter, permease FE384_02490 ENOG4105CNA YD repeat protein FE384_02520 ENOG4107653 Transcriptional regulator FE384_02530 ENOG4108N16 Negative regulator of allantoin and glyoxylate utilization operons. Binds to the gcl promoter and to the allS- allA intergenic region FE384_02535 ENOG41060W2 glyoxylate carboligase FE384_02540 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) FE384_02545 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase FE384_02550 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease FE384_02560 ENOG4105DTE Xanthine uracil vitamin C permease FE384_02565 ENOG4105BZW Glycerate kinase FE384_02570 ENOG4105S0E allantoin catabolism protein FE384_02575 ENOG4105CE7 Amidase, hydantoinase carbamoylase family FE384_02580 ENOG4105DG4 malate L-lactate dehydrogenase FE384_02585 ENOG4107R1Q Membrane protein FdrA FE384_02590 ENOG4107REC cytoplasmic protein FE384_02595 ENOG4105G5A Protein of unknown function (DUF2877) FE384_02600 ENOG4105C5B carbamate kinase FE384_02605 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit FE384_02610 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) FE384_02620 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) FE384_02630 ENOG4105S2T inner membrane protein YbcI FE384_02635 ENOG4105WQ3 Rna-binding protein FE384_02645 ENOG4108WDE Fimbrial protein FE384_02650 ENOG4108AF8 Chaperone FE384_02655 ENOG4105CW0 outer membrane usher protein FE384_02660 ENOG4108M66 Involved in regulation of length and mediation of adhesion of SfmA fimbriae (but not necessary for the production of fimbriae). Seems to be mannose binding adhesin (By similarity) FE384_02665 ENOG4108ZI2 Fimbrial protein FE384_02670 ENOG4108Q9V regulatoR FE384_02680 ENOG4108KU3 Integrase FE384_02710 ENOG410814C multidrug resistance protein FE384_02720 ENOG4107TII Recombinase FE384_02725 ENOG4108V1U phospholipid-binding protein FE384_02730 ENOG4108UQN AraC family transcriptional regulator FE384_02740 ENOG4108V2F protein ybcN in lambdoid DLP12 prophage regi FE384_02745 ENOG410757E Protein NinE homolog from lambdoid prophage DLP12 FE384_02750 ENOG4105RWQ Protein of unknown function (DUF1364) FE384_02765 ENOG4105HRS Antitermination protein FE384_02775 ENOG4105F2I Transposase FE384_02785 ENOG4105QFS Lysis protein S homolog from lambdoid prophage FE384_02790 ENOG4105KUS lysozyme FE384_02800 ENOG4105QYK bacteriophage lambda Bor protein homolog FE384_02815 ENOG4106YSC FE384_02820 ENOG4105FKG DNA packaging protein FE384_02825 ENOG4105UZW Tail fiber assembly protein FE384_02835 ENOG4108WF3 methyltransferase FE384_02845 ENOG4108MIW Induces the synthesis of acid phosphatase (AppA) and several other polypeptides (such as AppBC) during the deceleration phase of growth. It also acts as a transcriptional repressor for one group of proteins that are synthesized preferentially in exponential growth and for one group synthesized only in the stationary phase. Also involved in the stabilization of the sigma stress factor RpoS during stress conditions FE384_02850 ENOG4108NC2 Outer membrane protease FE384_02860 ENOG4105QUW FE384_02865 ENOG41090FC Bacteriophage N4 receptor, outer membrane subunit FE384_02870 ENOG410802X bacteriophage n4 adsorption protein b FE384_02875 ENOG4105GR3 Histidine kinase FE384_02880 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FE384_02885 ENOG4105ENJ RND efflux system, outer membrane lipoprotein FE384_02890 ENOG410624V efflux system protein FE384_02895 ENOG4105EP1 Efflux transporter rnd family, mfp subunit FE384_02900 ENOG4108IJF Heavy metal efflux pump, CzcA FE384_02905 ENOG4105C85 amino acid FE384_02910 ENOG4105CUY Mechanosensitive ion channel FE384_02915 ENOG4108RCM Nitroreductase FE384_02920 ENOG4105MSB protein, conserved in bacteria FE384_02925 ENOG4105WQ6 Membrane FE384_02940 ENOG4107635 Hok Gef family protein FE384_02945 ENOG4108SER Transposase FE384_02950 ENOG4108TSE Transferase FE384_02955 ENOG4107RNH Outer membrane receptor FepA FE384_02960 ENOG4105E93 esterase FE384_02965 ENOG41085A6 mbth domain-containing protein FE384_02970 ENOG4105C0W non-ribosomal peptide synthetase FE384_02975 ENOG4108QY5 Ferric enterobactin transport protein FE384_02980 ENOG4105E0A ABC, transporter FE384_02985 ENOG4105TVJ transport system, permease FE384_02990 ENOG4105DQ5 transport system permease protein FE384_03000 ENOG4105PEC Iron-enterobactin transporter periplasmic binding protein FE384_03005 ENOG4105E4F Isochorismate synthase FE384_03010 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase FE384_03015 ENOG4105WQI isochorismatase FE384_03020 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase FE384_03025 ENOG4108TZA Required for optimal enterobactin synthesis. Acts as a proofreading enzyme that prevents EntB misacylation by hydrolyzing the thioester bound existing between EntB and wrongly charged molecules (By similarity) FE384_03030 ENOG4105D22 carbon starvation protein FE384_03035 ENOG4105VCD cytoplasmic protein FE384_03040 ENOG4107SCQ Iron-containing alcohol dehydrogenase FE384_03045 ENOG4105CHM Aminotransferase FE384_03050 ENOG4105GTN ParB Domain Protein Nuclease FE384_03055 ENOG4105BZV Phosphoadenosine phosphosulfate reductase FE384_03060 ENOG4105DQS Transcriptional regulator FE384_03065 ENOG4108KHN disulfide isomerase, thiol-disulfide oxidase FE384_03070 ENOG4105D3R alkyl hydroperoxide reductase FE384_03075 ENOG4108JU3 Alkyl hydroperoxide reductase FE384_03080 ENOG4108U51 Universal stress protein FE384_03085 ENOG4105E2A Dehydrogenase FE384_03090 ENOG4105NXH GreA GreB family elongation factor FE384_03095 ENOG4105KTS ribonuclease FE384_03100 ENOG4107QPK )-transporter FE384_03115 ENOG4105CHY citrate lyase, alpha FE384_03120 ENOG4105CI0 Citrate lyase FE384_03130 ENOG4105DUA (citrate (pro-3S)-lyase ligase FE384_03135 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism FE384_03140 ENOG4106YYS transcriptional regulatory protein FE384_03145 ENOG4105CEE C4-dicarboxylate transporter FE384_03150 ENOG41079UR PagP is required both for biosynthesis of hepta-acylated lipid A species containing palmitate and for resistance to cationic antimicrobial peptides (CAMPs). It catalyzes the transfer of a palmitate chain (16 0) from the sn-1 position of a glycerophospholipid to the free hydroxyl group of the (R)-3- hydroxymyristate chain at position 2 of lipid A (endotoxin) (By similarity) FE384_03155 ENOG4105VEQ Cold shock protein FE384_03170 ENOG410607N Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatE shares overlapping functions with TatA (By similarity) FE384_03180 ENOG41064T2 transcriptional regulator, lysR family FE384_03195 ENOG4105DZ1 carboxypeptidase FE384_03200 ENOG4105K6T rare lipoprotein A FE384_03205 ENOG4105CNI cell division protein FtsW FE384_03210 ENOG4105CJN penicillin-binding protein FE384_03220 ENOG4105KEM Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) FE384_03225 ENOG4108TGR phosphatase FE384_03235 ENOG4105DJF DNA polymerase III, delta' subunit FE384_03250 ENOG4107PAI alpha helical protein FE384_03255 ENOG4105EUU Sel1 domain protein repeat-containing protein FE384_03260 ENOG41069CF Protein of unknown function (DUF1266) FE384_03265 ENOG4105QFC Hsc56 co-chaperone of HscC FE384_03270 ENOG4107JFD Sel1 repeat FE384_03275 ENOG41069CF Protein of unknown function (DUF1266) FE384_03280 ENOG4105QFC Hsc56 co-chaperone of HscC FE384_03285 ENOG4105F7F Chaperone FE384_03295 ENOG4105CDA abc transporter atp-binding protein FE384_03300 ENOG4105DRP amino acid AbC transporter FE384_03305 ENOG4105EAD ABC transporter FE384_03310 ENOG4107RP9 extracellular solute-binding protein, family 3 FE384_03315 ENOG4105F2I Transposase FE384_03320 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) FE384_03325 ENOG4108JU5 Magnesium and cobalt efflux protein FE384_03335 ENOG4105C9A Phoh family FE384_03345 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family FE384_03380 ENOG4105CAQ asparagine synthetase FE384_03385 ENOG4105D4U had-superfamily hydrolase, subfamily iia FE384_03390 ENOG4105E2R ROK family FE384_03395 ENOG4105CE4 GlcNAc 6-P deacetylase FE384_03405 ENOG4105CI1 PTS System FE384_03420 ENOG4105GX6 (LipO)protein FE384_03425 ENOG41090R7 Ferric uptake FE384_03435 ENOG4105MHQ Low-potential electron donor to a number of redox enzymes (By similarity) FE384_03440 ENOG4105NNH LexA regulated protein FE384_03445 ENOG4105EV9 Alpha Beta Hydrolase FE384_03450 ENOG4107CDU Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated (By similarity) FE384_03455 ENOG4107QIX Phosphoglucomutase (EC 5.4.2.2 FE384_03475 ENOG4105D5Q Arginine ornithine antiporter FE384_03480 ENOG4105CXN decarboxylase FE384_03490 ENOG4105EEX Two component transcriptional regulator (Winged helix family FE384_03495 ENOG4105C08 Histidine kinase FE384_03520 ENOG4105XIQ Protein of unknown function (DUF2517) FE384_03525 ENOG4105CNA YD repeat protein FE384_03530 ENOG41079JQ Membrane FE384_03540 ENOG4106R09 FE384_03560 ENOG4107SEY Conserved Protein FE384_03565 ENOG4105CVP deoxyribo-dipyrimidine photolyase FE384_03570 ENOG4105DUX Transporter FE384_03575 ENOG4107QNR UPF0135 protein FE384_03580 ENOG4105P4J Allophanate hydrolase, subunit 1 FE384_03585 ENOG4107R7A Allophanate hydrolase subunit 2 FE384_03600 ENOG4108KK1 membrane protein AbrB duplication FE384_03605 ENOG4108MY7 Fimbrial FE384_03610 ENOG4108TTM chaperone FE384_03615 ENOG4106PG1 outer membrane usher protein FE384_03620 ENOG4106UBK fimbrial-like adhesin protein FE384_03625 ENOG4105BZN citrate synthase FE384_03635 ENOG4108UTY succinate dehydrogenase, cytochrome b556 subunit FE384_03640 ENOG4105N1I succinate dehydrogenase, hydrophobic membrane anchor protein FE384_03645 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) FE384_03650 ENOG4105E33 succinate dehydrogenase FE384_03655 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 FE384_03660 ENOG4105C7S Dehydrogenase FE384_03670 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha FE384_03675 ENOG4105FDP GntR family transcriptional regulator FE384_03680 ENOG4105DM4 PTS System FE384_03685 ENOG4105C8I hydrolase, family 38 FE384_03690 ENOG4105C4M (Ubiquinol oxidase) subunit I FE384_03695 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii FE384_03705 ENOG4105KJB cyd operon protein YbgE FE384_03710 ENOG4107YD3 Thioesterase FE384_03715 ENOG4105E02 MotA TolQ exbB proton channel FE384_03720 ENOG4105M8F Biopolymer transport protein exbD tolR FE384_03725 ENOG4108Z82 Cell envelope integrity inner membrane protein TolA FE384_03735 ENOG4105KCK Peptidoglycan-associated lipoprotein FE384_03740 ENOG4105UFD tol-pal system protein YbgF FE384_03790 ENOG4106Z1T Nicotinamide Mononucleotide Transporter FE384_03795 ENOG4105PGM cation diffusion facilitator family transporter FE384_03800 ENOG4105JND homeobox protein FE384_03805 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) FE384_03815 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) FE384_03825 ENOG4105F0Z galactose-1-phosphate uridylyltransferase FE384_03830 ENOG4105CMR udp-glucose 4-epimerase FE384_03835 ENOG4105DKW ABC transporter FE384_03840 ENOG4105F4R Transcriptional regulator mode FE384_03845 ENOG410680R Protein of unknown function (DUF2592) FE384_03850 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein FE384_03855 ENOG4105E0C molybdate abc transporter FE384_03860 ENOG4105CGB Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system (By similarity) FE384_03865 ENOG4108K4B hydrolase FE384_03875 ENOG4105F04 LysR family Transcriptional regulator FE384_03880 ENOG4105C7F AcnD-accessory protein PrpF FE384_03885 ENOG4107QPK )-transporter FE384_03890 ENOG4107QM5 aconitate hydratase FE384_03895 ENOG4105NBR Pectinesterase FE384_03900 ENOG4108V1U phospholipid-binding protein FE384_03905 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) FE384_03915 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) FE384_03920 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) FE384_03925 ENOG4105E78 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) FE384_03935 ENOG4105CHW UPF0052 protein FE384_03945 ENOG4108RIR Molybdenum cofactor biosynthesis protein FE384_03955 ENOG4105M00 molybdopterin converting factor, subunit 1 FE384_03960 ENOG4108ZAF Molybdopterin FE384_03965 ENOG4105HFZ Membrane FE384_03970 ENOG410733J conserved inner membrane protein FE384_03975 ENOG4107UXM Membrane FE384_03980 ENOG4105DZQ phospholipase D Transphosphatidylase FE384_03985 ENOG4105X23 Endonuclease Exonuclease phosphatase FE384_03990 ENOG4105I9U inner membrane protein ybhQ FE384_03995 ENOG4107QWP ABC-2 type transporter FE384_04000 ENOG4107QWP ABC-2 type transporter FE384_04005 ENOG4105CJ1 ABC, transporter FE384_04015 ENOG4107MVR Transcriptional regulator FE384_04020 ENOG4105C1J atp-dependent rna helicase FE384_04025 ENOG4108UV1 cellular component movement FE384_04030 ENOG4105DVT helicase FE384_04035 ENOG4108MTB glycosyl transferase family FE384_04040 ENOG4105DG4 malate L-lactate dehydrogenase FE384_04045 ENOG4105VR4 UPF0379 protein ybiJ FE384_04050 ENOG4105KSC Transcriptional regulator, TraR DksA family FE384_04060 ENOG4108IU3 tonb-dependent siderophore receptor FE384_04065 ENOG4105ZY9 UPF0379 protein ybiM FE384_04075 ENOG4105D8X mechanosensitive ion channel FE384_04080 ENOG4105CDA abc transporter atp-binding protein FE384_04085 ENOG4105E5Q amino acid AbC transporter FE384_04090 ENOG4107R0W ABC transporter FE384_04100 ENOG4107AQZ Membrane FE384_04110 ENOG4108T1M outer membrane protein x FE384_04115 ENOG4108I6E Sulfatase FE384_04125 ENOG4105KST dependent repressor FE384_04130 ENOG4105F4P )-transporter FE384_04135 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein FE384_04140 ENOG4105C5H ABC transporter FE384_04145 ENOG41072TH Protein of unknown function (DUF1479) FE384_04150 ENOG4108HCJ Hydrolase FE384_04155 ENOG4105C6N Formate acetyltransferase FE384_04160 ENOG4105F1A Pyruvate formate-lyase FE384_04165 ENOG4107T9Z Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) FE384_04170 ENOG4105D06 uba thif-type nad fad binding protein FE384_04175 ENOG4105CVM Molybdenum cofactor synthesis domain protein FE384_04180 ENOG4105D44 asparaginase FE384_04185 ENOG4108JQ6 ABC transporter FE384_04190 ENOG4105DEF Extracellular solute-binding protein, family 5 FE384_04200 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FE384_04205 ENOG4105BZU Histidine kinase FE384_04210 ENOG41064RH membrane protein YliF FE384_04220 ENOG4105UFT Represses biofilm formation in M9C glu and LB glu media but not in M9C and LB media. Seems to act as a global regulator of several genes involved in catabolite repression and stress response and regulation of the uptake and export of signaling pathways. Could be involved the regulation of indole as well as uptake and export of AI-2 through a cAMP-dependent pathway FE384_04225 ENOG4105D8V Glucose sorbosone dehydrogenase FE384_04230 ENOG4108TGY Glutathione S-transferase FE384_04235 ENOG4105DZ1 carboxypeptidase FE384_04240 ENOG4107FB0 transcriptional regulator DeoR family FE384_04245 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase FE384_04250 ENOG4107QF7 multi-drug FE384_04260 ENOG4108HCJ Hydrolase FE384_04265 ENOG4106UW1 Major Facilitator superfamily FE384_04270 ENOG4108RFG Tetr family transcriptional regulator FE384_04280 ENOG4105GWF inner membrane protein YbjM FE384_04285 ENOG41090BQ Glutaredoxin FE384_04290 ENOG4105X20 member of the soxRS regulon which mediates in part the increased levels of superoxide in response to oxidative stress FE384_04295 ENOG4108DBC nitroreductase FE384_04305 ENOG4108RMJ sensory transduction regulator FE384_04310 ENOG4107RUE extracellular solute-binding protein family 1 FE384_04315 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FE384_04320 ENOG4105F38 ABC transporter, permease FE384_04325 ENOG4105D38 putrescine abc transporter FE384_04330 ENOG4105RBQ inner membrane protein ybjO FE384_04340 ENOG4106TNF Periplasmic binding protein FE384_04345 ENOG4105DMR ABC, transporter FE384_04350 ENOG4105GBT ABC transporter FE384_04355 ENOG4106PMH Extracellular solute-binding protein family 3 FE384_04360 ENOG4105E5Z arginine transporter ATP-binding subunit FE384_04365 ENOG41064MM (LipO)protein FE384_04375 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase FE384_04380 ENOG4107VBM 3-beta hydroxysteroid dehydrogenase isomerase FE384_04385 ENOG4105CGD Nad-dependent epimerase dehydratase FE384_04390 ENOG4105C5W Aldolase FE384_04395 ENOG4105C7K acetolactate synthase FE384_04400 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) FE384_04410 ENOG4105DWU Membrane FE384_04415 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) FE384_04420 ENOG4105CPB ATP-dependent endonuclease of the OLD family FE384_04425 ENOG4108MJ5 VirK protein FE384_04430 ENOG4105DJY efflux transporter, rnd family, mfp subunit FE384_04435 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) FE384_04440 ENOG4105VEQ Cold shock protein FE384_04450 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit FE384_04465 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) FE384_04475 ENOG4108JJ8 (ABC) transporter FE384_04480 ENOG4108JJ9 ABC, transporter FE384_04485 ENOG4105C3M thioredoxin reductase FE384_04490 ENOG4105EW9 transcriptional regulator AsnC family FE384_04495 ENOG4105CNU cell division protein FtsK FE384_04505 ENOG4105D1H recombination factor protein RarA FE384_04515 ENOG4107QY8 reductase FE384_04520 ENOG4105QAX Iron-sulfur FE384_04525 ENOG4107KGK dmso reductase anchor subunit FE384_04530 ENOG4105CHJ isochorismatase hydrolase FE384_04540 ENOG4105E5D amino acid FE384_04545 ENOG410642W LysR family Transcriptional regulator FE384_04550 ENOG4108X0B nad(p)h dehydrogenase (quinone) FE384_04555 ENOG4105F1A Pyruvate formate-lyase FE384_04560 ENOG4105C6N Formate acetyltransferase FE384_04565 ENOG4105TMB Formate nitrite transporter FE384_04570 ENOG4105DDY UPF0142 protein ycaO FE384_04575 ENOG4107VMU Membrane FE384_04590 ENOG4108K0D peptidase, M48 FE384_04600 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) FE384_04610 ENOG4108EQH DNA internalization-related competence protein ComEC Rec2 FE384_04615 ENOG4105BZ1 (ABC) transporter FE384_04620 ENOG4105CHD Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity) FE384_04625 ENOG4105T0Z Conserved Protein FE384_04640 ENOG4107VR7 transferase activity, transferring phosphorus-containing groups FE384_04645 ENOG4107S90 membrAne FE384_04650 ENOG4106371 Methyltransferase FE384_04660 ENOG4105DAH Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF (By similarity) FE384_04670 ENOG4105DIT ErfK YbiS YcfS YnhG family protein FE384_04675 ENOG4105EAQ (twin-arginine translocation) pathway signal FE384_04680 ENOG4105C5X domain protein FE384_04685 ENOG4105CGF Aromatic amino acid aminotransferase FE384_04690 ENOG4105FCK Membrane FE384_04705 ENOG4105CD8 aminopeptidase N FE384_04710 ENOG4105E2Y ABC, transporter FE384_04715 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component FE384_04725 ENOG4105GVF (ABC) transporter FE384_04730 ENOG4108UZX fmn reductase FE384_04735 ENOG41071VI Part of the elfADCG-ycbUVF fimbrial operon, which promotes adhesion of bacteria to different abiotic surfaces. ElfA is the major fimbrial subunit produced by this operon FE384_04740 ENOG4106JJN Part of the elfADCG-ycbUVF fimbrial operon, which promotes adhesion of bacteria to different abiotic surfaces. Could be required for the biogenesis of the ElfA fimbriae FE384_04745 ENOG4105CW0 outer membrane usher protein FE384_04750 ENOG4108MDY Fimbrial FE384_04755 ENOG4105Q7J Fimbrial FE384_04760 ENOG4105MX3 Fimbrial FE384_04765 ENOG4106PH7 chaperone FE384_04775 ENOG4108T7E Contributes to the efficiency of the cell division process by stabilizing the polymeric form of the cell division protein FtsZ. Acts by promoting interactions between FtsZ protofilaments and suppressing the GTPase activity of FtsZ (By similarity) FE384_04780 ENOG4105QVC MOSC domain-containing protein FE384_04785 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) FE384_04790 ENOG4105C5H ABC transporter FE384_04795 ENOG4105F1S paraquat-inducible protein a FE384_04800 ENOG4105DY2 Paraquat-inducible protein b FE384_04805 ENOG4108Q2G (LipO)protein FE384_04810 ENOG4105WFT During stationary phase, converts 70S ribosomes to an inactive dimeric form (100S ribosomes) (By similarity) FE384_04820 ENOG4105DAN ATP-dependent protease FE384_04830 ENOG4105UYK outer membrane protein a FE384_04840 ENOG4108RZ1 DNA transformation protein FE384_04845 ENOG4105EM2 membrane FE384_04850 ENOG410901E Membrane FE384_04855 ENOG41088T4 Helicase IV FE384_04870 ENOG4105K4P CoA-binding domain protein FE384_04885 ENOG4105VSY K01512 acylphosphatase EC 3.6.1.7 FE384_04890 ENOG4108Z0T Part of a sulfur-relay system (By similarity) FE384_04895 ENOG4108MN8 Membrane FE384_04905 ENOG4105E3S small subunit FE384_04910 ENOG4105DPX Hydrogenase, large subunit FE384_04915 ENOG4105X7T Ni Fe-hydrogenase, b-type cytochrome subunit FE384_04920 ENOG4108USZ hydrogenase FE384_04925 ENOG4108VXY Hydrogenase-1 operon protein HyaE FE384_04930 ENOG4105MVP hydrogenase-1 operon protein HyaF FE384_04935 ENOG4105C4M (Ubiquinol oxidase) subunit I FE384_04940 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii FE384_04950 ENOG4105D6F Phosphatase FE384_04955 ENOG4105D75 Capsular exopolysaccharide family FE384_04960 ENOG4107ZF2 Phosphatase FE384_04965 ENOG4105DAY polysaccharide export protein FE384_04970 ENOG4105E3R (LipO)protein FE384_04975 ENOG4108W78 Pfam:DUF1017 FE384_04980 ENOG4108Y9B (LipO)protein FE384_04995 ENOG41060EU Cold shock-like protein FE384_05000 ENOG4105VEQ Cold shock protein FE384_05015 ENOG4106H71 Overexpression increases levels of unsaturated fatty acids and suppresses both the temperature-sensitive fabA6 mutation and cold-sensitive secG null mutation FE384_05020 ENOG4105HEE Binding Domain protein FE384_05025 ENOG4105BZU Histidine kinase FE384_05030 ENOG4108SV3 Tmao reductase system periplasmic protein tort FE384_05035 ENOG4106WF9 DNA-binding transcriptional regulator TorR FE384_05040 ENOG4105CUW cytochrome C-TYPE protein FE384_05045 ENOG4107QY8 reductase FE384_05050 ENOG4108SBI Involved in the biogenesis of TorA. Acts on TorA before the insertion of the molybdenum cofactor and, as a result, probably favors a conformation of the apoenzyme that is competent for acquiring the cofactor (By similarity) FE384_05070 ENOG4105D6F Phosphatase FE384_05075 ENOG4105XH3 FE384_05085 ENOG4105XF5 Escherichia coli IMT2125 genomic chromosome, IMT2125 FE384_05090 ENOG4105C2W permease FE384_05105 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) FE384_05130 ENOG4108R86 Transcriptional regulator FE384_05135 ENOG4105C26 Dehydrogenase FE384_05145 ENOG4105CK7 Sodium proline symporter FE384_05155 ENOG410650H (LipO)protein FE384_05160 ENOG4105DBE peroxidase FE384_05165 ENOG4105D5M phosphate starvation-inducible protein FE384_05170 ENOG4106FQ9 Biofilm PGA synthesis protein PgaD FE384_05175 ENOG4105CND Glycosyl transferase, family 2 FE384_05180 ENOG4107BJW polysaccharide deacetylase FE384_05185 ENOG4108TUY outer membrane protein PgaA FE384_05190 ENOG4105BZU Histidine kinase FE384_05205 ENOG4108T85 Membrane FE384_05235 ENOG4107XHZ cytoplasmic chaperone TorD family protein FE384_05240 ENOG4108UQ5 membrane protein YcdZ FE384_05250 ENOG4108WYR Curli production assembly transport component, CsgF FE384_05255 ENOG4108XDW curli assembly protein CsgE FE384_05260 ENOG41086KC Transcriptional regulator FE384_05265 ENOG4108U0V Curli are coiled surface structures that assemble preferentially at growth temperatures below 37 degrees Celsius. Curli can bind to fibronectin. The minor subunit is the nucleation component of curlin monomers FE384_05270 ENOG4105G76 Curli are coiled surface structures that assemble preferentially at growth temperatures below 37 degrees Celsius. Curli can bind to fibronectin FE384_05275 ENOG4105RK8 Plays a role in the extracellular assembly of CsgA into thin aggregative fimbriae (Tafi) fibers. Assembly may also require CsgE. Tafi are thought to be assembled via an extracellular nucleation-precipitation (ENP) pathway, and possibly also via an intracellular non-CsgC-dependent pathway (By similarity) FE384_05285 ENOG4108UVJ appr-1-p processing domain protein FE384_05305 ENOG4105C3A Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs) (By similarity) FE384_05310 ENOG4105NAC (LipO)protein FE384_05315 ENOG4108W47 Acidic protein msyB FE384_05325 ENOG4105D1S lipid A biosynthesis FE384_05335 ENOG4108YYC ycei family FE384_05340 ENOG4105DS1 cytochrome b561 FE384_05345 ENOG4106974 biofilm formation FE384_05355 ENOG4105PVA Biofilm formation regulatory protein BssS FE384_05360 ENOG4105MEA DNA damage-inducible protein i FE384_05370 ENOG4105F3T (LipO)protein FE384_05375 ENOG4105E9S glutaredoxin 2 FE384_05385 ENOG4105D9U N-acetyltransferase FE384_05395 ENOG4105EP9 oxidoreductase FE384_05400 ENOG4105CJR Integral membrane protein (MviN FE384_05405 ENOG4105QVD Flagella synthesis protein FlgN FE384_05410 ENOG4105M9M anti-sigma28 factor FlgM FE384_05415 ENOG4105CKS Flagella basal body P-ring formation protein flgA FE384_05420 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) FE384_05425 ENOG4108ZC9 flagellar basal-body rod protein flgc FE384_05430 ENOG4105W00 Flagellar hook capping protein FE384_05435 ENOG4105BZE flagellar hook protein, FlgE FE384_05440 ENOG4108KPB Flagellar basal-body rod protein FlgF FE384_05445 ENOG4105CGA flagellar basal-body rod protein FlgG FE384_05460 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj FE384_05465 ENOG4105E1Q flagellar hook-associated protein FE384_05470 ENOG4105DTJ flagellar hook-associated protein FE384_05475 ENOG4107QQB Ribonuclease E FE384_05480 ENOG4105EI2 Pseudouridine synthase FE384_05485 ENOG4108UHJ MAF-like protein FE384_05490 ENOG4105FCQ metal-binding, possibly nucleic acid-binding protein FE384_05510 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase FE384_05515 ENOG4105CHR reductase FE384_05520 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) FE384_05525 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) FE384_05530 ENOG4105YAZ 4-amino-4-deoxychorismate lyase FE384_05535 ENOG4105HHA aminodeoxychorismate lyase FE384_05545 ENOG4107QRG dna polymerase iii FE384_05550 ENOG4105F8V Hydrolase, tatD family FE384_05555 ENOG4105CI1 PTS System FE384_05560 ENOG4105CNM Receptor FE384_05565 ENOG4105K59 histidine triad (HIT) protein FE384_05570 ENOG41090DQ Lipoprotein FE384_05575 ENOG4108WEF Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b) (By similarity) FE384_05595 ENOG4105CEP NADH dehydrogenase FE384_05600 ENOG4107MBR 17 kDa surface antigen FE384_05605 ENOG4108IND Tetr family transcriptional regulator FE384_05610 ENOG4105RC8 Reduces the permeability of the outer membrane to copper. Seems to be involved in the regulation of biofilm formation. May decrease biofilm formation by repressing cell-cell interaction and cell surface interaction FE384_05615 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein FE384_05620 ENOG4108JA2 transcriptioN-repair coupling factor FE384_05625 ENOG4105IQC Inner membrane protein YcfT FE384_05630 ENOG4105D60 lipoprotein releasing system transmembrane protein FE384_05635 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) FE384_05640 ENOG4105D60 lipoprotein releasing system transmembrane protein FE384_05650 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) FE384_05670 ENOG4105D38 putrescine abc transporter FE384_05675 ENOG4105F38 ABC transporter, permease FE384_05680 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FE384_05690 ENOG4105EZE Cupin 4 family protein FE384_05695 ENOG4105IFJ Histidine kinase FE384_05700 ENOG4105XJC Two component transcriptional regulator (Winged helix family FE384_05705 ENOG4107QTF adenylosuccinate lyase FE384_05725 ENOG4108R99 pseudouridine synthase FE384_05730 ENOG4108HMX isocitrate dehydrogenase (NADP) FE384_05735 ENOG4106JA9 FE384_05740 ENOG4106J3D FE384_05745 ENOG4106VW7 Interacts with a short DNA sequence about one-quarter of the way into the major capsid protein gene 23 of T4, and the inhibition occurs when this late gene of the virus is expressed FE384_05750 ENOG4108I1J Integrase FE384_05755 ENOG4105QYW Excisionase-like protein from lambdoid prophage 14 FE384_05770 ENOG4107712 FE384_05775 ENOG4105RDA repressor FE384_05780 ENOG41078CG DNA-binding transcriptional regulator FE384_05785 ENOG4108S1U FE384_05795 ENOG4105CAR Terminase, large subunit FE384_05805 ENOG4105EFC phage portal protein HK97 family FE384_05810 ENOG4108T86 baseplate J family protein FE384_05815 ENOG4105Y0G tail protein FE384_05820 ENOG4105Y9F tail fiber protein FE384_05830 ENOG4108US3 tail fiber assembly FE384_05840 ENOG4108C33 Resolvase FE384_05845 ENOG4108R4U Hnh endonuclease FE384_05850 ENOG4108HMX isocitrate dehydrogenase (NADP) FE384_05865 ENOG41064WM Uncharacterized protein YcgX FE384_05870 ENOG4108XDN Transcriptional regulator FE384_05875 ENOG4105BZU Histidine kinase FE384_05880 ENOG4105WKE Probably a connector protein for RcsB C regulation of biofilm formation, providing additional signal input into the two- component signaling pathway. Partially antagonizes the activities of YmgA and AriR, proteins that, via the Rcs phosphorelay, promote the synthesis of colanic acid, an exopolysaccharide and matrix component FE384_05885 ENOG41077SS Probably a connector protein for RcsB C regulation of biofilm formation, providing additional signal input into the two- component signaling pathway. May serve to stimulate biofilm maturation, probably via the Rcs phosphorelay. Mild overexpression at 16 degrees Celsius increases the production of colanic acid, an exopolysaccharide and matrix component, and reduces adhesive curli fimbriae expression. Both of these effects require RcsB FE384_05895 ENOG410738I uncharacterized protein ymgC FE384_05900 ENOG4105BZU Histidine kinase FE384_05920 ENOG410658X FE384_05955 ENOG4107QMS site-determining protein FE384_05965 ENOG4105S66 prophage protein FE384_05970 ENOG41066UD Inhibits activity of g-type lysozyme, which confers increased lysozyme tolerance to the bacterium FE384_05980 ENOG4105FBJ fumarylacetoacetate (faa) hydrolase FE384_05990 ENOG4106PXS Toxin, which has some hemolytic activity towards mammalian cells. Acts by forming a pore-like structure upon contact with mammalian cells FE384_05995 ENOG4105KT5 UmuD protein FE384_06000 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) FE384_06005 ENOG410635M Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein (By similarity) FE384_06020 ENOG4105ED1 spovr family FE384_06030 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) FE384_06040 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A FE384_06050 ENOG4108T7K Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Increasing levels of c-di-GMP lead to decreased motility (By similarity) FE384_06055 ENOG4105Y3U Transglycosylase-associated protein FE384_06070 ENOG4105VDH Dihydroxyacetone kinase FE384_06075 ENOG4108UTZ Dihydroxyacetone kinase FE384_06080 ENOG4105CMT Dihydroxyacetone kinase FE384_06085 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family FE384_06090 ENOG4105I1J Autotransporter FE384_06095 ENOG4105C3G gtp-binding protein FE384_06105 ENOG4105MGX transcription activated by CRP (cyclic AMP receptor protein), a global transcription factor involved in regulation of metabolism in enteric bacteria FE384_06110 ENOG4105CHH sulfate transporter FE384_06115 ENOG4105C5T Phosphoribosyl pyrophosphate synthase FE384_06120 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) FE384_06130 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) FE384_06140 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) FE384_06145 ENOG4108YY7 Invasion gene expression up-regulator SirB FE384_06150 ENOG41063JG Transcriptional regulator FE384_06190 ENOG4105EWV Sodium calcium exchanger membrane region FE384_06195 ENOG4105WS7 Cation transport regulator FE384_06200 ENOG4108NH8 Cation transport protein FE384_06205 ENOG41090EX DsrE family FE384_06210 ENOG4105ID0 Putative invasin FE384_06215 ENOG4105WH1 Two component transcriptional regulator luxr family FE384_06220 ENOG4105BZU Histidine kinase FE384_06225 ENOG4105DQQ Major facilitator superfamily MFS_1 FE384_06230 ENOG4105CRU nitrate reductase, alpha subunit FE384_06235 ENOG4108IUE nitrate reductase beta subunit FE384_06240 ENOG4105R3A Nitrate reductase FE384_06245 ENOG41076YT nitrate reductase, gamma subunit FE384_06280 ENOG4105CIY formyltetrahydrofolate deformylase FE384_06290 ENOG4105D78 K07001 NTE family protein FE384_06295 ENOG4105I93 response regulator FE384_06300 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase FE384_06305 ENOG4108SAU DNA-binding protein H-ns FE384_06310 ENOG4107104 thymidine kinase FE384_06320 ENOG4108EKI Dehydrogenase FE384_06325 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein FE384_06330 ENOG4105F2I Transposase FE384_06335 ENOG4108J59 Extracellular solute-binding protein, family 5 FE384_06345 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FE384_06350 ENOG4105C3U ABC transporter FE384_06355 ENOG4108JQ7 (ABC) transporter FE384_06375 ENOG4107SVH Potassium channel protein FE384_06380 ENOG4105K9H YciI-like protein FE384_06385 ENOG410822N TonB family FE384_06390 ENOG4105NAU thioesterase Superfamily protein FE384_06410 ENOG4105EIF outer membrane protein W FE384_06415 ENOG4108N8X transition metal ion binding FE384_06420 ENOG4108Z9Z response to DNA damage stimulus FE384_06440 ENOG4105DK0 Indole-3-glycerol phosphate synthase FE384_06445 ENOG4108EFP Anthranilate synthase component II FE384_06450 ENOG4105CRQ synthase (Component I) FE384_06460 ENOG4105DB7 PHP domain protein FE384_06465 ENOG4107RTD sua5 ycio yrdc ywlc family protein FE384_06470 ENOG4105EG3 transmembrane signal peptide protein FE384_06475 ENOG4105FE9 pseudouridine synthase FE384_06480 ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase FE384_06485 ENOG4105UBK short-chain dehydrogenase reductase FE384_06490 ENOG4105ERU peptidase FE384_06495 ENOG4105RKX Protein of unknown function (DUF2498) FE384_06500 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) FE384_06505 ENOG4107R11 Transcriptional regulator FE384_06525 ENOG4107QM5 aconitate hydratase FE384_06535 ENOG4105EYK Phosphatidylglycerophosphatase B FE384_06540 ENOG4105Q4A inner membrane protein yciS FE384_06545 ENOG4105CFV Tetratricopeptide repeat protein FE384_06555 ENOG4108ZJT translation initiation factor, Sui1 FE384_06560 ENOG41061RM osmotically inducible lipoprotein FE384_06565 ENOG4105N2W Transcriptional regulator FE384_06575 ENOG4105BZU Histidine kinase FE384_06590 ENOG4105Q4T oxidoreductase FE384_06595 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH FE384_06600 ENOG4105WDY DNA (cytosine-5-)-methyltransferase FE384_06605 ENOG4108JQ2 peptide transport system atp-binding protein FE384_06610 ENOG4108JQ3 Peptide ABC transporter ATP-binding protein FE384_06615 ENOG4108EU3 peptide transport system, permease FE384_06620 ENOG4108I5W peptide transport system, permease protein FE384_06625 ENOG4108HIY periplasmic FE384_06630 ENOG4105N0E Protein of unknown function (DUF2543) FE384_06635 ENOG4105CUB amino acid FE384_06645 ENOG4105CFQ glutamine synthetase FE384_06650 ENOG4108Z86 Glutamine amidotransferase FE384_06655 ENOG4107VRI Transcriptional regulator FE384_06660 ENOG4105C26 Dehydrogenase FE384_06665 ENOG4105CJP fad dependent oxidoreductase FE384_06670 ENOG4108JPW Aminotransferase FE384_06675 ENOG4105E51 psp operon transcriptional activator FE384_06680 ENOG41087YS Phage shock protein A FE384_06685 ENOG4105YYT phage shock protein B FE384_06690 ENOG4105FM1 phage shock protein C FE384_06695 ENOG4105NNG Peripheral inner membrane phage-shock protein FE384_06700 ENOG4105K8Z Phage shock protein FE384_06705 ENOG4107QW3 Sucrose phosphorylase FE384_06710 ENOG4105WEM extracellular solute-binding protein FE384_06715 ENOG4105HS6 binding-protein-dependent transport systems inner membrane Component FE384_06720 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component FE384_06725 ENOG4107RRD Dehydrogenase FE384_06730 ENOG4107TYA transient receptor potential locus FE384_06735 ENOG4105CK5 oxidoreductase FE384_06740 ENOG4105C71 hydrolase family 65, central catalytic FE384_06745 ENOG4107URF beta-phospho-glucomutase FE384_06755 ENOG4107EFV Outer membrane protein G FE384_06760 ENOG4105FKQ transcriptional regulator FE384_06765 ENOG4105CM6 amino acid regulated cytosolic protein FE384_06775 ENOG4108JU8 Transcriptional regulator FE384_06780 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) FE384_06785 ENOG4107S8C mandelate racemase muconate lactonizing FE384_06790 ENOG4105KXI murein peptide amidase A FE384_06805 ENOG4105ENX hydrolase FE384_06810 ENOG4105EQ2 LysR family Transcriptional regulator FE384_06815 ENOG4107QSI ABC, transporter FE384_06820 ENOG4105D64 Mechanosensitive ion channel FE384_06825 ENOG4105F2I Transposase FE384_06830 ENOG4105S5I Membrane FE384_06835 ENOG4105Q9Y Universal stress protein FE384_06840 ENOG4105DS0 Transcriptional regulator, Crp Fnr family FE384_06845 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) FE384_06850 ENOG4105CFC Transporter FE384_06855 ENOG4107RT5 aminobenzoyl-glutamate utilization protein B FE384_06860 ENOG4105CH2 amidohydrolase FE384_06865 ENOG4106KR7 LysR family Transcriptional regulator FE384_06870 ENOG4108DG9 Smr protein MutS2 FE384_06875 ENOG4105BZU Histidine kinase FE384_06885 ENOG4105C1J atp-dependent rna helicase FE384_06895 ENOG4107R08 Integrase FE384_06900 ENOG4107160 Rac prophage FE384_06905 ENOG41070YT Rac prophage FE384_06910 ENOG4106YAH restriction alleviation and modification enhancement FE384_06915 ENOG4108PNI recT protein FE384_06920 ENOG41076J9 exonuclease VIII FE384_06930 ENOG4107C82 Rac prophage FE384_06955 ENOG410649Z repressor FE384_06960 ENOG4105W7J DNA binding FE384_06970 ENOG4105ZTP Protein of unknown function (DUF1376) FE384_06975 ENOG4105JBR DNA replication protein FE384_06990 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) FE384_06995 ENOG4108ES9 ParB domain protein nuclease FE384_07020 ENOG4105F2I Transposase FE384_07030 ENOG4108X9F tail fiber protein FE384_07035 ENOG4105UZW Tail fiber assembly protein FE384_07040 ENOG4105MN3 Resolvase FE384_07045 ENOG4105W3V DNA-binding, transcriptional regulator FE384_07055 ENOG4108RW8 Universal stress protein F FE384_07060 ENOG4105FCK Membrane FE384_07065 ENOG4105D95 Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity) FE384_07075 ENOG41090X5 Heat shock protein hslJ FE384_07080 ENOG4105C5I Dehydrogenase FE384_07085 ENOG4107H52 Dicarboxylate transport FE384_07090 ENOG410689M (LipO)protein FE384_07095 ENOG4105WXT Conserved Protein FE384_07100 ENOG4108WFR AraC Family Transcriptional Regulator FE384_07105 ENOG4105C26 Dehydrogenase FE384_07110 ENOG4105F11 amine oxidase FE384_07115 ENOG4105DXM phenylacetic acid degradation protein FE384_07120 ENOG4105CRS phenylacetate-CoA oxygenase PaaG subunit FE384_07125 ENOG4105N76 Phenylacetate-CoA oxygenase, subunit FE384_07130 ENOG4105D9S phenylacetate-CoA oxygenase PaaI subunit FE384_07135 ENOG4108ZA2 phenylacetate-CoA oxygenase PaaJ subunit FE384_07140 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) FE384_07145 ENOG4105E39 Enoyl-CoA hydratase FE384_07150 ENOG4108UKI Enoyl-CoA hydratase FE384_07155 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase FE384_07160 ENOG4108ZJI phenylacetic acid degradation protein FE384_07165 ENOG4105CHU acetyl-coa acetyltransferase FE384_07170 ENOG4105DZS Phenylacetate-CoA ligase FE384_07175 ENOG4105V9J phenylacetic acid degradation operon negative regulatory protein FE384_07180 ENOG4108Z0R Transferase FE384_07200 ENOG4105F9F transposase FE384_07210 ENOG4107EF2 surface-exposed virulence protein FE384_07215 ENOG4107S5I aldo keto reductase FE384_07225 ENOG4108UMZ Cdp-alcohol phosphatidyltransferase FE384_07230 ENOG4108HPI phosphatidate Cytidylyltransferase FE384_07235 ENOG4105E8V Alpha Beta Hydrolase Fold protein FE384_07240 ENOG41077RS Phosphatase FE384_07250 ENOG4105CQ7 ATP-dependent helicase FE384_07255 ENOG4107DB1 DUF218 domain FE384_07260 ENOG4105C26 Dehydrogenase FE384_07270 ENOG4105CPW cytochrome b561 FE384_07275 ENOG4105UPP uncharacterized protein ydcA FE384_07280 ENOG4107NK6 Hok/gef family FE384_07285 ENOG4105C8Q Methyl-accepting chemotaxis FE384_07290 ENOG4105DDW LysR family Transcriptional regulator FE384_07295 ENOG4105E32 cytoplasmic protein FE384_07305 ENOG4105Z2P Protein of unknown function (DUF465) FE384_07310 ENOG4108Z9I -acetyltransferase FE384_07315 ENOG4107WE3 acetyltransferase YdcK FE384_07320 ENOG4108NKP c4-dicarboxylate transporter malic acid transport protein FE384_07325 ENOG41088CC tellurite resistance protein tehB FE384_07330 ENOG4108KKZ (LipO)protein FE384_07340 ENOG4105D7V transposase FE384_07345 ENOG4105DKK Benzoate FE384_07350 ENOG4108JCI Transcriptional regulator FE384_07355 ENOG4105CFP Peptidase U32 FE384_07360 ENOG4105RR0 Protein of unknown function (DUF2554) FE384_07370 ENOG4105PF0 Antitoxin component of a toxin-antitoxin (TA) module. Functions as an mRNA interferase antitoxin FE384_07375 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family FE384_07380 ENOG4107TYH extracellular solute-binding protein family 1 FE384_07385 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) FE384_07390 ENOG4105D81 ABC transporter, permease FE384_07395 ENOG4105NRK Binding-protein-dependent transport systems, inner membrane component FE384_07410 ENOG410654E Membrane FE384_07415 ENOG4105R71 cytoplasmic protein FE384_07420 ENOG4108T9Y Inner membrane protein ydcZ FE384_07425 ENOG4108Z7F N-acetyltransferase FE384_07430 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein FE384_07435 ENOG4108WYP Transcriptional regulator FE384_07440 ENOG4105CHB tonB-dependent Receptor FE384_07445 ENOG4108NS2 receptor FE384_07450 ENOG4105C85 amino acid FE384_07455 ENOG4108N27 Glutathione S-transferase FE384_07470 ENOG4107TV1 YD repeat protein FE384_07490 ENOG410600T transposase FE384_07500 ENOG4108MEJ flavin reductase domain protein FE384_07505 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase FE384_07510 ENOG4105JAB phenazine biosynthesis protein, phzf family FE384_07515 ENOG4105D0D Nitrate reductase 2, gamma subunit FE384_07520 ENOG4108NZN Respiratory nitrate reductase 2 delta chain FE384_07525 ENOG4108IUE nitrate reductase beta subunit FE384_07530 ENOG4105CRU nitrate reductase, alpha subunit FE384_07535 ENOG4107QND Nitrite extrusion protein FE384_07545 ENOG4108UI3 Leucine Rich repeat FE384_07555 ENOG4105RPH Inner membrane protein YddG FE384_07565 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein FE384_07570 ENOG4108MG3 formate dehydrogenase FE384_07575 ENOG41084S7 Plasmid maintenance system antidote protein FE384_07580 ENOG4105DQ4 alcohol dehydrogenase FE384_07590 ENOG4107AV5 Although this protein associates with the 30S subunit of the ribosome it is not considered to be a bona fide ribosomal protein FE384_07595 ENOG4105TPS biofilm-dependent modulation protein FE384_07600 ENOG4108Z9K Osmotically inducible protein FE384_07605 ENOG4107H6U ABC transporter FE384_07610 ENOG4105C3U ABC transporter FE384_07615 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FE384_07620 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component FE384_07625 ENOG4105DEF Extracellular solute-binding protein, family 5 FE384_07630 ENOG4108UQS dipeptidase FE384_07635 ENOG4105BZU Histidine kinase FE384_07640 ENOG4105BZU Histidine kinase FE384_07645 ENOG4105F32 YngK protein FE384_07650 ENOG4105E5D amino acid FE384_07655 ENOG4105CVK Glutamate decarboxylase FE384_07660 ENOG4107RAN Peptidase, M16 FE384_07665 ENOG4105PE1 Receptor FE384_07670 ENOG4105CQ0 ABC transporter FE384_07680 ENOG4105C4X radical SAM domain protein FE384_07685 ENOG4105ENH Sulfatase FE384_07690 ENOG4105Z68 AraC Family Transcriptional Regulator FE384_07700 ENOG4107QKC Oxidoreductase alpha (molybdopterin) subunit FE384_07705 ENOG4106PIH fimbrial-like protein ydeQ FE384_07710 ENOG4106318 fimbrial-like protein YdeR FE384_07715 ENOG4108WDE Fimbrial protein FE384_07730 ENOG4105CAF HipA N-terminal domain protein FE384_07735 ENOG41061P8 Persistence to inhibition of murein or DNA biosynthesis regulatory protein FE384_07750 ENOG4108EMV Catalyzes the phosphorylation of autoinducer 2 (AI-2) to phospho-AI-2, which subsequently inactivates the transcriptional regulator LsrR and leads to the transcription of the lsr operon. Phosphorylates the ring-open form of 4,5-dihydroxy-2,3- pentanedione (DPD), which is the precursor to all AI-2 signaling molecules, at the C5 position (By similarity) FE384_07755 ENOG4105DKT Transcriptional regulator FE384_07760 ENOG4105C2J ABC transporter FE384_07765 ENOG41071MT Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane FE384_07770 ENOG4105F5R ABC transporter FE384_07775 ENOG4105D4B ABC, transporter FE384_07780 ENOG41061GT Aldolase FE384_07785 ENOG4105K34 Involved in the degradation of phospho-AI-2, thereby terminating induction of the lsr operon and closing the AI-2 signaling cycle. Catalyzes the cleavage of phosphorylated 4,5- dihydroxy-2,3-pentanedione (P-DPD) to 2-phosphoglycolic acid (PG) and another three-carbon compound FE384_07795 ENOG4105FFC UPF0187 protein FE384_07800 ENOG4107QZW Altronate oxidoreductase FE384_07805 ENOG4105BZU Histidine kinase FE384_07810 ENOG4105M0C cytoplasmic protein FE384_07815 ENOG4105CSV Glutaminase FE384_07820 ENOG4105C26 Dehydrogenase FE384_07825 ENOG4105EGI Transcriptional regulator FE384_07845 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes FE384_07850 ENOG4108XW0 May be a transcriptional activator of genes involved in the multiple antibiotic resistance (Mar) phenotype. It can also activate genes such as sodA, zwf and micF FE384_07855 ENOG4106DNR multiple antibiotic resistance protein FE384_07860 ENOG4108594 Permease of the drug metabolite transporter FE384_07865 ENOG4105E5W Transporter FE384_07875 ENOG4105FSR swimming returnes to normal when residues 206-207 are both mutated to Ala. Overexpression also leads to a reduction in flagellar abundance and a 20-fold increase in c-di- GMP levels in vivo. Required for aminoglycoside-mediated induction of biofilm formation, it also plays a lesser role in biofilm production in response to other classes of translation inhibitors. The c-di-GMP produced by this enzyme up-regulates poly-GlcNAc production as well as the biofilm synthesis protein PgaD, although c-di-GMP is probably not the main inducing principle. Cyclic-di- GMP is a second messenger which controls cell surface-associated traits in bacteria FE384_07880 ENOG4108YDI single-species biofilm formation on inanimate substrate FE384_07885 ENOG4108WTK competence damage-inducible protein FE384_07890 ENOG4105DGW oligopeptidase A FE384_07895 ENOG4105EMU Dehydrogenase FE384_07900 ENOG4107XBN GntR Family Transcriptional Regulator FE384_07905 ENOG41061EV selenium-binding protein YdfZ FE384_07910 ENOG4105DEI Mannitol dehydrogenase FE384_07920 ENOG4105W3V DNA-binding, transcriptional regulator FE384_07925 ENOG4105MN3 Resolvase FE384_07930 ENOG4105UZW Tail fiber assembly protein FE384_07935 ENOG410685N tail fiber protein FE384_07940 ENOG4105FKG DNA packaging protein FE384_07945 ENOG4106YSC FE384_07950 ENOG41064WM Uncharacterized protein YcgX FE384_07955 ENOG4106H71 Overexpression increases levels of unsaturated fatty acids and suppresses both the temperature-sensitive fabA6 mutation and cold-sensitive secG null mutation FE384_07960 ENOG4106IAW FE384_07975 ENOG4105VEQ Cold shock protein FE384_07980 ENOG4108YV9 Protein of unknown function (DUF2514) FE384_07995 ENOG4105QFS Lysis protein S homolog from lambdoid prophage FE384_08000 ENOG4105VEQ Cold shock protein FE384_08015 ENOG4105HGD Antitermination protein FE384_08020 ENOG4108MXB Protein of unknown function (DUF968) FE384_08035 ENOG4105WI6 cell killing protein encoded within cryptic prophage FE384_08040 ENOG4105K4U addiction module toxin, RelE StbE family FE384_08075 ENOG41087BU transcriptional repressor DicA FE384_08100 ENOG4106G8A Qin prophage FE384_08125 ENOG4105CPQ Dehydrogenase FE384_08130 ENOG4105CXK mandelate racemase muconate lactonizing FE384_08145 ENOG4108MK9 spermidine N(1)-acetyltransferase FE384_08155 ENOG4105KBG Protein of unknown function (DUF1161) FE384_08160 ENOG4107QY8 reductase FE384_08165 ENOG4105C3J Cysteine desulfurase FE384_08170 ENOG4105QAX Iron-sulfur FE384_08175 ENOG4107KGK dmso reductase anchor subunit FE384_08180 ENOG4108NEM leader-binding protein dmsD FE384_08190 ENOG4105EWW Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) FE384_08195 ENOG4105DAG ROK family FE384_08200 ENOG4106NZI LysR family Transcriptional regulator FE384_08205 ENOG4105D94 Major Facilitator Superfamily FE384_08220 ENOG4105CVW peptidase s1 and s6 chymotrypsin hap FE384_08240 ENOG4105DSF transport protein FE384_08245 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) FE384_08250 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) FE384_08255 ENOG4105C5D exported protein FE384_08260 ENOG4105D5Q Arginine ornithine antiporter FE384_08265 ENOG410642E Short chain dehydrogenase FE384_08270 ENOG4105RA2 Membrane FE384_08275 ENOG4107EXC regulatoR FE384_08280 ENOG4105JJR Histidine kinase FE384_08290 ENOG4105C9Q fumarate hydratase class II FE384_08295 ENOG4107GFK fumarate FE384_08300 ENOG4105EIP mannose-6-phosphate isomerase FE384_08305 ENOG4106J39 exported protein FE384_08310 ENOG4108QNI outer membrane porin protein FE384_08315 ENOG4105CT4 transporter FE384_08320 ENOG4105CNT hydrolase family 2 FE384_08325 ENOG4105XEA Tetr family transcriptional regulator FE384_08330 ENOG4107ZQV short-chain dehydrogenase reductase FE384_08335 ENOG4107P2S Transcriptional regulator FE384_08340 ENOG4105CI1 PTS System FE384_08345 ENOG4105C87 Aminotransferase class I and II FE384_08355 ENOG4105D9R oxidoreductase FE384_08360 ENOG4106C6R beta-lactam resistance protein FE384_08365 ENOG4105QZ5 OriC-binding nucleoid-associated protein FE384_08370 ENOG4105M9B inner membrane protein ydgK FE384_08395 ENOG4108UQQ Electron transport complex FE384_08405 ENOG4105CSM endonuclease III FE384_08410 ENOG4105DUX Transporter FE384_08415 ENOG4108K3A Glutathione S-transferase FE384_08420 ENOG4107XGF functions in a salvage pathway. Uses pyridoxamine (By similarity) FE384_08435 ENOG410642K Lysozyme inhibitor FE384_08445 ENOG4108XTF Outer Membrane Lipoprotein FE384_08460 ENOG4105Y49 secretion protein, HlyD family FE384_08465 ENOG4105DSW Fusaric acid resistance protein FE384_08470 ENOG4108Z7T Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) FE384_08475 ENOG4107RGM aldo keto reductase FE384_08480 ENOG4105XZD Fe-S protein FE384_08485 ENOG4108WUH Transcriptional regulator, TetR family FE384_08490 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase FE384_08495 ENOG4108UYE Lactoylglutathione lyase FE384_08500 ENOG4105DH5 Responsible for the end-turnover of tRNA specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis (By similarity) FE384_08505 ENOG4107QRT dEAD DEAH box helicase FE384_08510 ENOG4105M2J Glutaredoxin FE384_08515 ENOG4105K4H Nlp p60 protein FE384_08520 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) FE384_08525 ENOG4105F27 Major Facilitator FE384_08540 ENOG4105F52 Transcriptional regulator FE384_08545 ENOG4105CZQ inner membrane transport protein YdhC FE384_08550 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase FE384_08555 ENOG4108R6K riboflavin synthase, subunit alpha FE384_08580 ENOG4105N0V mono-oxygenase ydhR FE384_08585 ENOG4108KTU conserved protein with FAD NAD(P)-binding domain FE384_08590 ENOG4108Y7C Conserved Protein FE384_08595 ENOG4108NWD Cytochrome FE384_08600 ENOG4108393 oxidoreductase Fe-S subunit FE384_08605 ENOG4105JVW FE384_08610 ENOG4105WE2 aldehyde ferredoxin oxidoreductase FE384_08615 ENOG4108PU5 4fe-4S ferredoxin, iron-sulfur binding domain protein FE384_08620 ENOG4105RFR Protein of unknown function (DUF2767) FE384_08625 ENOG4105CA9 Pyruvate kinase FE384_08630 ENOG4105KMX major outer membrane lipoprotein FE384_08635 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein FE384_08650 ENOG4105JRK feS assembly protein SufD FE384_08655 ENOG4105C3K feS assembly ATPase SufC FE384_08660 ENOG4105DIW FeS assembly protein SUFB FE384_08665 ENOG4108Z4V iron-sulfur cluster assembly FE384_08670 ENOG410671Z uncharacterized protein ydiH FE384_08675 ENOG4105KA0 thioesterase Superfamily protein FE384_08680 ENOG4105CQB FAD linked oxidase domain protein FE384_08685 ENOG4105IPI Membrane FE384_08695 ENOG4105SUA Ydil protein FE384_08700 ENOG4105EMV Major Facilitator FE384_08705 ENOG4105EMV Major Facilitator FE384_08720 ENOG4107R0K CoA transferase having broad substrate specificity for short-chain acyl-CoA thioesters with the activity decreasing when the length of the carboxylic acid chain exceeds four carbons (By similarity) FE384_08725 ENOG4105C1G acyl-Coa dehydrogenase FE384_08730 ENOG4105W4W Transcriptional regulator FE384_08735 ENOG4105CV7 Electron transfer flavoprotein FE384_08740 ENOG4105C10 Electron transfer flavoprotein FE384_08745 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase FE384_08750 ENOG41090P5 ferredoxin-like protein FE384_08755 ENOG4105CEY Amp-dependent synthetase and ligase FE384_08760 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) FE384_08770 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) FE384_08775 ENOG4106EDX Hemin uptake protein FE384_08785 ENOG4108TC0 Diguanylate phosphodiesterase FE384_08790 ENOG4108QBX (LipO)protein FE384_08800 ENOG4108V06 Glutathione peroxidase FE384_08815 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) FE384_08830 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) FE384_08835 ENOG41082NX 50s ribosomal protein l35 FE384_08860 ENOG4108NE3 Salt-induced outer membrane protein FE384_08865 ENOG4105DE4 1-phosphofructokinase FE384_08870 ENOG4105P10 Uncharacterized protein ydiZ FE384_08875 ENOG4105FGM Fructosamine kinase FE384_08880 ENOG4107PN8 YfeABCD locus regulator FE384_08885 ENOG4107UW8 HAD-superfamily hydrolase subfamily IA variant 3 FE384_08890 ENOG4107K5X Membrane-bound metal-dependent hydrolase FE384_08895 ENOG4108ETY sodium dicarboxylate symporter FE384_08910 ENOG4105CH6 catalase FE384_08920 ENOG4105F8D glycoside hydrolase family 4 FE384_08925 ENOG4105EZV Transcriptional regulator FE384_08930 ENOG4105VCP PTS System FE384_08935 ENOG4105CK1 PTS System FE384_08940 ENOG4105VZJ PTS System FE384_08945 ENOG4105KKI DNA-binding transcriptional activator OsmE FE384_08955 ENOG4105DKD Incises the DNA at the 3' side of a lesion during nucleotide excision repair. Incises the DNA farther away from the lesion than UvrC. Not able to incise the 5' site of a lesion. When a lesion remains because UvrC is not able to induce the 3' incision, Cho incises the DNA. Then UvrC makes the 5' incision. The combined action of Cho and UvrC broadens the substrate range of nucleotide excision repair (By similarity) FE384_08965 ENOG4108SPG Periplasmic Protein FE384_08985 ENOG4105F4X arginine FE384_08995 ENOG4105CGK Exodeoxyribonuclease III FE384_09000 ENOG4108RSN SNARE associated Golgi FE384_09005 ENOG4108KCW iron-sulfur cluster binding FE384_09010 ENOG4108N5C SNARE associated Golgi protein-related protein FE384_09015 ENOG4107ZN8 Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) FE384_09020 ENOG4105VNH ABC transporter solute-binding protein FE384_09025 ENOG4105CXZ ABC transporter, permease FE384_09030 ENOG4108VGW abc transporter atp-binding protein FE384_09035 ENOG4107RM6 sulfurtransferase FE384_09040 ENOG4108T9J Cdp-alcohol phosphatidyltransferase FE384_09045 ENOG4105M6F mutator MutT protein FE384_09050 ENOG4105MTM Protein of unknown function (DUF1496) FE384_09055 ENOG4105D82 Glutamate dehydrogenase FE384_09060 ENOG41065FB inner membrane protein ynji FE384_09065 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) FE384_09075 ENOG41069NU Nitroreductase FE384_09080 ENOG4105D07 Signal peptide peptidase, SppA FE384_09085 ENOG4105HDK L-asparaginase FE384_09090 ENOG4108RWI nicotinamidase FE384_09095 ENOG4108KUU Inner membrane metabolite transport protein ydjE FE384_09100 ENOG4105E98 transcriptional regulator DeoR family FE384_09105 ENOG4105CPC Aldo Keto reductase FE384_09110 ENOG4107UH8 sugar kinase FE384_09115 ENOG4105D2N Aldolase FE384_09120 ENOG4105CPQ Dehydrogenase FE384_09125 ENOG4107TE1 transport protein FE384_09130 ENOG4105CPQ Dehydrogenase FE384_09135 ENOG4105VUT cytoplasmic protein FE384_09145 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase FE384_09150 ENOG4105DSB aldose 1-epimerase FE384_09155 ENOG4105CV8 reductase FE384_09160 ENOG4105GNX MltA-interacting MipA family protein FE384_09165 ENOG4105CYN Serine protein kinase FE384_09175 ENOG4106KTS Inner membrane protein yeaI FE384_09180 ENOG4108KHP Diguanylate cyclase FE384_09185 ENOG4108KXH Ybak prolyl-tRNA synthetase associated FE384_09200 ENOG4105R1U AraC Family Transcriptional Regulator FE384_09205 ENOG4105DJ2 Major Facilitator Superfamily FE384_09210 ENOG4105K78 MarR family Transcriptional regulator FE384_09215 ENOG4105UCG Domain of unknown function (DUF333) FE384_09220 ENOG410620I Diguanylate cyclase FE384_09225 ENOG4106G4W FE384_09235 ENOG4105Y3U Transglycosylase-associated protein FE384_09240 ENOG4105YP6 Domain of unknown function (DUF1869) FE384_09245 ENOG4108YS1 cytoplasmic protein FE384_09255 ENOG4105EJC lysr family transcriptional regulator FE384_09260 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) FE384_09265 ENOG4105C94 Transporter FE384_09270 ENOG4105DVW rieske (2Fe-2S) FE384_09275 ENOG4105E3J oxidoreductase FE384_09280 ENOG4105ZIE Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity) FE384_09285 ENOG4105CEY Amp-dependent synthetase and ligase FE384_09290 ENOG4105Y4Z Outer Membrane Lipoprotein FE384_09295 ENOG41072GX Peptidase M22 Glycoprotease FE384_09300 ENOG4105DVT helicase FE384_09305 ENOG4105M4H endoribonuclease L-psp FE384_09310 ENOG4105V2F Uncharacterized protein yoac FE384_09320 ENOG4105CRQ synthase (Component I) FE384_09330 ENOG4105EJQ L-serine dehydratase FE384_09335 ENOG4107XTP (EAL) domain protein FE384_09340 ENOG4105EE5 Membrane protein terC FE384_09345 ENOG4108EQA pts system FE384_09350 ENOG4105ETZ PTS System FE384_09355 ENOG4105F3R pts system mannose fructose sorbose family iid FE384_09370 ENOG4105DHI Methyltransferase FE384_09375 ENOG4105VEQ Cold shock protein FE384_09380 ENOG410610J Protein of unknown function (DUF2627) FE384_09385 ENOG4105Q3Y exported protein FE384_09395 ENOG4105TIK FE384_09400 ENOG4105J4Q Transcriptional regulator FE384_09405 ENOG4105C0R drug resistance transporter emrb qaca subfamily FE384_09415 ENOG4105CN1 protease FE384_09425 ENOG4108ZGC gaf domain protein FE384_09430 ENOG4105H2K paraquat-inducible protein a FE384_09435 ENOG4105DY2 Paraquat-inducible protein b FE384_09445 ENOG4105WT8 Protein of unknown function (DUF1480) FE384_09450 ENOG4105UVW uncharacterized protein yebW FE384_09455 ENOG4108R1E Serine threonine protein phosphatase 1 FE384_09460 ENOG4105NKT exported protein FE384_09465 ENOG4108PNC copper resistance FE384_09470 ENOG4105FXM Copper resistance protein FE384_09475 ENOG4105MPK DNA polymerase III subunit theta FE384_09480 ENOG4108YGA nitrilase cyanide hydratase and apolipoprotein n-acyltransferase FE384_09485 ENOG4105UMD exodeoxyribonuclease X FE384_09490 ENOG4105CUG Oligopeptidase b FE384_09495 ENOG4108Q2J Inner membrane protein YebE FE384_09500 ENOG4105RSZ secreted protein FE384_09505 ENOG4105X2V dna damage-inducible protein FE384_09515 ENOG4108UHU Aldolase FE384_09520 ENOG4105C01 Dihydroxy-acid dehydratase FE384_09525 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase FE384_09530 ENOG4106KNT transcriptional regulator FE384_09535 ENOG4105CA9 Pyruvate kinase FE384_09540 ENOG4105NWR lipid A biosynthesis (Kdo)2-(Lauroyl)-lipid IVA acyltransferase FE384_09545 ENOG4105DR5 peptidase FE384_09550 ENOG4105NXV High-affinity zinc uptake system protein FE384_09555 ENOG4105FDK ABC transporter FE384_09560 ENOG4105FAV ABC, transporter FE384_09580 ENOG4107S01 Repressor protein MetJ FE384_09590 ENOG4105CDY transcriptional regulatory protein FE384_09595 ENOG4108TIT dATP pyrophosphohydrolase FE384_09605 ENOG4105D3W isochorismatase FE384_09610 ENOG41081XQ Conserved Protein FE384_09615 ENOG4105WJG Glutathione FE384_09630 ENOG4107QY8 reductase FE384_09635 ENOG4105CUW cytochrome C-TYPE protein FE384_09645 ENOG4106ZCM YecM protein FE384_09660 ENOG4105W13 flagellar protein FE384_09665 ENOG4105D7B Flagellar biosynthesis protein flha FE384_09670 ENOG4105D00 flagellar biosynthetic protein flhB FE384_09675 ENOG4108KCC Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P) (By similarity) FE384_09680 ENOG4108VYJ response regulator receiver protein FE384_09685 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) FE384_09690 ENOG4105BZU Histidine kinase FE384_09695 ENOG4105C8Q Methyl-accepting chemotaxis FE384_09700 ENOG4105C8Q Methyl-accepting chemotaxis FE384_09705 ENOG4108V3W Chemotaxis protein, CheW FE384_09710 ENOG4105CBS Chea signal transduction histidine kinase FE384_09715 ENOG4105ER2 Ompa motb domain protein FE384_09720 ENOG4107RD7 Flagellar Motor Protein, MotA FE384_09725 ENOG4106CIA Functions in complex with FlhD as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region FE384_09740 ENOG4108VA4 Universal stress protein FE384_09750 ENOG4108K4C ec 3.1.3.12 FE384_09755 ENOG4105CNN ABC, transporter FE384_09760 ENOG4105C2J ABC transporter FE384_09765 ENOG4105DMK Periplasmic binding protein LacI transcriptional regulator FE384_09770 ENOG4108UEC Ferritin-like protein FE384_09775 ENOG4105N4N Protein of unknown function (DUF2766) FE384_09785 ENOG4105P23 (LipO)protein FE384_09790 ENOG41090A1 ferritin FE384_09795 ENOG4105VVZ metal-binding protein FE384_09800 ENOG4105E0U tyrosine-specific transport protein FE384_09805 ENOG4106RHG Yeca family FE384_09825 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase FE384_09835 ENOG4105WH1 Two component transcriptional regulator luxr family FE384_09845 ENOG4105XVG cytoplasmic protein FE384_09850 ENOG4105VJY transcriptional regulator FE384_09855 ENOG4105CDA abc transporter atp-binding protein FE384_09860 ENOG4105E5Q amino acid AbC transporter FE384_09870 ENOG4105EAB amino acid AbC transporter FE384_09875 ENOG4108M9K flagella biosynthesis protein FliZ FE384_09880 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FE384_09885 ENOG4105I03 Flagellin FE384_09890 ENOG4105DTS flagellar hook-associated FE384_09895 ENOG4105MQ3 flagellar protein FliS FE384_09900 ENOG4105YXP it directly binds FlhC, thus inhibiting the binding of the FlhC FlhD complex to class 2 promoters, resulting in decreased expression of class 2 flagellar operons. As a chaperone, effects FliD transition to the membrane by preventing its premature polymerization, and by directing it to the export apparatus (By similarity) FE384_09905 ENOG4105E5K Alpha-amylase FE384_09910 ENOG4108W9D (LipO)protein FE384_09915 ENOG41066VF YeeE YedE family protein FE384_09920 ENOG4105KSU Redox protein FE384_09925 ENOG4108RAV Conserved protein FE384_09930 ENOG4108HF7 Gcn5-related n-acetyltransferase FE384_09955 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) FE384_09960 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) FE384_09965 ENOG41090PJ Flagellar assembly protein FE384_09975 ENOG4105GSA Flagellar export protein flij FE384_09980 ENOG4105WF4 Flagellar hook-length control protein FE384_09985 ENOG4107ZI8 flagellar basal body-associated protein flil FE384_09990 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) FE384_09995 ENOG4105DD5 Flagellar motor switch protein FE384_10000 ENOG4105K0P flagellar biosynthesis protein FE384_10005 ENOG4105CN7 Flagellar biosynthetic protein FliP FE384_10010 ENOG4105VS8 Flagellar biosynthetic protein fliq FE384_10015 ENOG4105D19 Role in flagellar biosynthesis (By similarity) FE384_10020 ENOG4107TKS colanic acid capsular biosynthesis activation protein A FE384_10035 ENOG4105YX3 cellular response to acidity FE384_10045 ENOG4105BZU Histidine kinase FE384_10050 ENOG4105VNZ cytoplasmic protein FE384_10055 ENOG4105CKW Inner membrane protein yedI FE384_10060 ENOG4105FDR Membrane FE384_10065 ENOG41090BB DNA mismatch endonuclease (vsr) FE384_10070 ENOG4105DVF Cytosine-specific methyltransferase FE384_10075 ENOG4105EST Metal Dependent Phosphohydrolase FE384_10080 ENOG4105Y0K Inner membrane protein YedR FE384_10100 ENOG4107ZY3 Histidine kinase FE384_10105 ENOG4105CK6 Two component transcriptional regulator (Winged helix family FE384_10110 ENOG4105VT2 5-hydroxyisourate hydrolase FE384_10125 ENOG4108MEK Metal-binding protein YodA FE384_10130 ENOG4108VKM cytochrome b561 FE384_10140 ENOG4105EXZ Involved in the regulation of ptsG expression by binding and inactivating Mlc (By similarity) FE384_10150 ENOG4105TNG K13735 adhesin invasin FE384_10160 ENOG4105CSH Transporter FE384_10165 ENOG4105FYV Amp nucleosidase FE384_10170 ENOG4105CDY transcriptional regulatory protein FE384_10180 ENOG4105UQX Mate efflux family protein FE384_10190 ENOG4107R11 Transcriptional regulator FE384_10195 ENOG4106P55 Transcriptional regulator FE384_10205 ENOG4108PXI ErfK YbiS YcfS YnhG FE384_10220 ENOG4108YZT Adenosylcobinamide kinase FE384_10230 ENOG4105F2I Transposase FE384_10265 ENOG4105F4K antigen 43 FE384_10270 ENOG4108PZQ Inner membrane protein YeeR FE384_10275 ENOG4108YGG dna repair protein FE384_10280 ENOG4106WJE Protein of unknown function (DUF987) FE384_10285 ENOG4105MAW Antitoxin component of a toxin-antitoxin (TA) module. Labile antitoxin that counteracts the effect of the CbtA (YeeV) toxin. It does not bind to the cognate toxin but instead binds to MreB and FtsZ (the toxin targets), enhancing their polymerization by forming higher-order bundles FE384_10320 ENOG4105DR8 Membrane FE384_10325 ENOG4108S5C Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell (By similarity) FE384_10330 ENOG4105DZ1 carboxypeptidase FE384_10335 ENOG4105CJB Exodeoxyribonuclease I FE384_10345 ENOG4105CUC YeeE YedE family protein FE384_10350 ENOG4105CUB amino acid FE384_10360 ENOG4105EQ1 Transcriptional regulator FE384_10365 ENOG4108535 NAD dependent epimerase/dehydratase family FE384_10370 ENOG4105KRQ Addiction module toxin, Txe YoeB family FE384_10375 ENOG4105VTW prevent-host-death family FE384_10390 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) FE384_10400 ENOG4105ECC imidazole-glycerol-phosphate dehydratase FE384_10405 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) FE384_10420 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase FE384_10425 ENOG4108KPN Confers a modal distribution of chain length on the O- antigen component of lipopolysaccharide (LPS). Gives rise to a reduced number of short chain molecules and increases in numbers of longer molecules, with a modal value of 13 (in strain O111 M92) and of 17 (in strain K12) FE384_10430 ENOG4105C6Y Udp-glucose 6-dehydrogenase FE384_10435 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) FE384_10445 ENOG4105F2I Transposase FE384_10455 ENOG4108TMJ glycosyl transferase FE384_10470 ENOG4107B0W May link the O-antigen tetrasaccharide units into long chains, giving rise to typical smooth LPS FE384_10475 ENOG4105D5D udp-galactopyranose mutase FE384_10480 ENOG4105ER6 polysaccharide biosynthesis protein FE384_10485 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase FE384_10500 ENOG4105ECJ Glycosyl Transferase FE384_10505 ENOG4108NYJ Colanic acid FE384_10510 ENOG4107RXY Glycosyl transferase FE384_10515 ENOG41068PY Colanic acid biosynthesis acetyltransferase wcaB FE384_10520 ENOG41090RK glycosyl transferase FE384_10530 ENOG4105KJF protein tyrosine phosphatase FE384_10535 ENOG4105DAY polysaccharide export protein FE384_10540 ENOG4105EE5 Membrane protein terC FE384_10545 ENOG4108GAE asmA family FE384_10555 ENOG4105DBI uridine monophosphokinase FE384_10560 ENOG4105BZU Histidine kinase FE384_10565 ENOG4105D03 DNA-3-methyladenine glycosylase II FE384_10570 ENOG4105R8A Heat shock protein FE384_10575 ENOG4106E1W protein with protein kinase and helix-hairpin-helix DNA-binding FE384_10580 ENOG4105ZD5 Uncharacterized protein conserved in bacteria (DUF2314) FE384_10585 ENOG4105UM3 Inherit from NOG: serine threonine phosphoprotein phosphatase FE384_10590 ENOG4108M24 von Willebrand factor, type A FE384_10625 ENOG4105EB3 Histidine kinase FE384_10630 ENOG4105E3W Two component transcriptional regulator (Winged helix family FE384_10635 ENOG4105KWI UPF0339 protein FE384_10640 ENOG4105CFP Peptidase U32 FE384_10645 ENOG4105ZTC transcriptional activator, Ogr delta FE384_10660 ENOG41076Z6 Uncharacterized protein yegR FE384_10685 ENOG4107WTH Galactitol-1-phosphate dehydrogenase FE384_10690 ENOG4105DT3 PTS system, galactitol-specific IIc component FE384_10695 ENOG41090UW PTS System FE384_10700 ENOG41082GB PTS system galactitol-specific transporter subunit IIA FE384_10715 ENOG4105EIE fructose-bisphosphate aldolase FE384_10720 ENOG4105EAA nucleoside FE384_10725 ENOG4108KD5 ADP-ribosylation crystallin J1 FE384_10730 ENOG4108TFM Kinase, PfkB family FE384_10735 ENOG4105FDP GntR family transcriptional regulator FE384_10740 ENOG4108UQ1 hydrolase, family 25 FE384_10745 ENOG4105DWF phosphomethylpyrimidine kinase FE384_10760 ENOG41061MD high-affinity nickel-transporter FE384_10765 ENOG4108Z1S Influences nickel and cobalt homeostasis. May act by modulating RcnA-mediated export of these ions to avoid excess efflux. Not involved in nickel import and does not bind nickel or cobalt ions directly FE384_10770 ENOG410662B Type-1 fimbrial protein FE384_10775 ENOG4105CW0 outer membrane usher protein FE384_10780 ENOG4108MQF Chaperone FE384_10785 ENOG41063W2 Fimbrial protein FE384_10790 ENOG41067AK Protein of unknown function (DUF2574) FE384_10795 ENOG4105D1F ATP-binding protein FE384_10810 ENOG4108KDT Molybdate metabolism regulator FE384_10820 ENOG4105KKX ATPase associated with various cellular activities aaa_5 FE384_10825 ENOG4105RD5 FE384_10830 ENOG4105DEG Vwa containing coxe family protein FE384_10835 ENOG410903U zinc ion binding FE384_10840 ENOG4108YCW (LipO)protein FE384_10845 ENOG4108W15 Protein of unknown function (DUF1456) FE384_10850 ENOG4108NEV two component transcriptional regulator, LytTR family FE384_10855 ENOG4108HRK Histidine kinase FE384_10860 ENOG4108XDN Transcriptional regulator FE384_10870 ENOG4105WJV Binding-protein-dependent transport systems, inner membrane component FE384_10875 ENOG4108IJ8 ABC transporter FE384_10880 ENOG4107T5X Binding-protein-dependent transport systems, inner membrane component FE384_10885 ENOG4107SI7 Substrate-binding region of abc-type glycine betaine transport system FE384_10890 ENOG4107QK4 glycoside hydrolase, family 3 domain protein FE384_10895 ENOG4105CXG d-lactate dehydrogenase FE384_10900 ENOG41061WM D-Alanyl-D-Alanine FE384_10905 ENOG41069YE inner membrane protein yohC FE384_10910 ENOG4105KHU inner membrane protein YohD FE384_10915 ENOG4105H9W Short-chain dehydrogenase reductase Sdr FE384_10930 ENOG4105FBT Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity) FE384_10940 ENOG41067MG lrgb family FE384_10950 ENOG4107GZ4 SanA protein FE384_10955 ENOG4105Y9N Membrane FE384_10960 ENOG4105BZ8 glutamate synthase FE384_10965 ENOG4107SJI Dehydrogenase FE384_10970 ENOG4108HWV )-transporter FE384_10975 ENOG4105C2J ABC transporter FE384_10980 ENOG4105EMA Periplasmic binding protein LacI transcriptional regulator FE384_10985 ENOG41060NJ transcriptional regulator FE384_10990 ENOG4105DHF Membrane FE384_11000 ENOG4105C4W S-formylglutathione hydrolase FE384_11005 ENOG4105D05 Receptor FE384_11010 ENOG4108IQI permease FE384_11015 ENOG4105DUM transcriptional regulator, lysR family FE384_11020 ENOG4105HMI Membrane FE384_11025 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) FE384_11030 ENOG4105DD7 kinase (PfkB family FE384_11035 ENOG4105D9N nucleoside FE384_11045 ENOG4108Y4K DNA-binding transcriptional activator FE384_11050 ENOG4105D9N nucleoside FE384_11055 ENOG4105D53 Catalyzes the hydrolysis of pseudouridine 5'-phosphate (PsiMP) to ribose 5-phosphate and uracil (By similarity) FE384_11060 ENOG4105DD7 kinase (PfkB family FE384_11065 ENOG4105DM4 PTS System FE384_11070 ENOG4105DE4 1-phosphofructokinase FE384_11075 ENOG4105DTZ bifunctional PTS system fructose-specific transporter subunit IIA HPr protein FE384_11080 ENOG4105S8Q sugar efflux transporter FE384_11085 ENOG4105KRS Proteinase inhibitor FE384_11095 ENOG4105DEI Mannitol dehydrogenase FE384_11100 ENOG4105CKI cobalamin synthesis protein FE384_11105 ENOG41076MN Phosphoesterase, PA-phosphatase related FE384_11110 ENOG4107TT5 NLP P60 protein FE384_11115 ENOG4105CXC rtn protein FE384_11120 ENOG4105E43 Extracellular solute-binding protein, family 5 FE384_11125 ENOG4108I5X binding-protein-dependent transport systems inner membrane Component FE384_11130 ENOG4108IYQ Binding-protein-dependent transport systems inner membrane component FE384_11135 ENOG4108JQ5 ABC transporter FE384_11140 ENOG4105HG6 FE384_11145 ENOG4105C2C drug resistance transporter, Bcr CflA FE384_11150 ENOG4105I08 Pseudouridine synthase FE384_11155 ENOG4105CFI type iii restriction protein res subunit FE384_11175 ENOG4105E68 Sulfatase FE384_11190 ENOG4105F2I Transposase FE384_11195 ENOG4105WH1 Two component transcriptional regulator luxr family FE384_11200 ENOG4105KWW Biogenesis protein FE384_11205 ENOG4107QX9 Thiol disulfide interChange protein FE384_11210 ENOG4105DA4 cytochrome c-type biogenesis protein FE384_11220 ENOG4105X3C heme exporter protein FE384_11225 ENOG41060IM Heme exporter protein FE384_11230 ENOG4105CA5 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes (By similarity) FE384_11235 ENOG4107EV4 once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system (By similarity) FE384_11240 ENOG4105CUW cytochrome C-TYPE protein FE384_11245 ENOG4108ZMS Electron transfer subunit of the periplasmic nitrate reductase complex NapAB (By similarity) FE384_11250 ENOG4105GXZ Ferredoxin-type protein NapH FE384_11255 ENOG4108BGM Quinol dehydrogenase periplasmic component FE384_11265 ENOG41061Q0 Assembly protein for periplasmic nitrate reductase FE384_11270 ENOG4108ZNS ferredoxin-type protein NapF FE384_11285 ENOG4105IBP Cyclic peptide transporter FE384_11290 ENOG4105CF1 Alkylated DNA repair protein FE384_11295 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) FE384_11300 ENOG4105CJ2 (LipO)protein FE384_11305 ENOG4105FCK Membrane FE384_11310 ENOG4105E3G Phosphotransfer intermediate protein in two-component regulatory system with RcsBC FE384_11315 ENOG41068CG regulatoR FE384_11320 ENOG4105BZU Histidine kinase FE384_11325 ENOG4105BZU Histidine kinase FE384_11330 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family FE384_11335 ENOG4107QP7 CoA-transferase subunit A FE384_11340 ENOG4107QNJ CoA-transferase subunit B FE384_11345 ENOG4105CRW Short chain fatty acid transporter FE384_11355 ENOG4105EDV vault protein FE384_11360 ENOG41081SK signal peptide protein FE384_11370 ENOG4108QJJ Protein of unknown function (DUF1175) FE384_11375 ENOG4107FKF Uncharacterized protein conserved in bacteria (DUF2138) FE384_11380 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) FE384_11390 ENOG4107GHC outer membrane autotransporter FE384_11395 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) FE384_11400 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) FE384_11405 ENOG4105XPH Ferredoxin FE384_11410 ENOG4105FQR PH-inducible protein involved in stress response FE384_11420 ENOG4106MZZ glycerophosphoryl diester phosphodiesterase FE384_11425 ENOG4105CXY transporter FE384_11430 ENOG4107R5Y anaerobic glycerol-3-phosphate dehydrogenase, subunit A FE384_11440 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) FE384_11445 ENOG4105DNE Transposase FE384_11460 ENOG4105CSP Major Facilitator Superfamily FE384_11470 ENOG4107258 Transcriptional regulator FE384_11480 ENOG4108UII YfaZ family FE384_11510 ENOG4105F73 Catalyzes the deformylation of 4-deoxy-4-formamido-L- arabinose-phosphoundecaprenol to 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity) FE384_11515 ENOG4105SA9 Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity) FE384_11525 ENOG4105U65 Translocates 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol (alpha-L-Ara4N-phosphoundecaprenol) from the cytoplasmic to the periplasmic side of the inner membrane (By similarity) FE384_11530 ENOG4106GZG polymyxin resistance protein B FE384_11535 ENOG4105CEY Amp-dependent synthetase and ligase FE384_11545 ENOG4108IPT Naphthoate synthase FE384_11560 ENOG4105E4F Isochorismate synthase FE384_11565 ENOG4105TNS Conserved Protein FE384_11570 ENOG4107YB6 acetyltransferase, (GNAT) family FE384_11580 ENOG4105Z6G Protease that can act as an efficient and specific deubiquitinating enzyme in vitro. Does not possess desumoylating and deneddylating activities. The physiological substrate is FE384_11585 ENOG4105CP2 von willebrand factor, type a FE384_11590 ENOG4107VAM peptidase, m28 FE384_11595 ENOG4105GDX Domain of unknown function (DUF1877) FE384_11600 ENOG4105ZD8 FE384_11605 ENOG4106EES FE384_11610 ENOG4106HDC FE384_11620 ENOG4105C8S subunit m FE384_11625 ENOG4105D65 subunit l FE384_11630 ENOG41080EA NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) FE384_11635 ENOG4107UFS subunit j FE384_11640 ENOG4105P3U NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) FE384_11650 ENOG4107R0R NADH dehydrogenase subunit g FE384_11655 ENOG4107QIZ NADH dehydrogenase FE384_11660 ENOG4105GKE subunit e FE384_11665 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) FE384_11680 ENOG4107NQ8 LysR family Transcriptional regulator FE384_11685 ENOG4105CHM Aminotransferase FE384_11695 ENOG4107QWE )-transporter FE384_11700 ENOG4105EVE HAD-superfamily hydrolase subfamily IA variant 3 FE384_11715 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) FE384_11720 ENOG4105C6K Malic enzyme FE384_11725 ENOG4105CSX c4-dicarboxylate anaerobic carrier FE384_11730 ENOG4105PTV Nudix Hydrolase FE384_11735 ENOG4108RE9 Phosphodiesterase FE384_11740 ENOG4108SHQ Glutathione S-transferase FE384_11750 ENOG4105KKP D-erythro-7,8-dihydroneopterin triphosphate 2'-epimerase FE384_11755 ENOG4105ECP epimerase FE384_11760 ENOG4105DNE Transposase FE384_11765 ENOG4108JEH abc transporter atp-binding protein FE384_11770 ENOG4106YG3 ABC transporter FE384_11775 ENOG4105DSP amino acid AbC transporter FE384_11780 ENOG4105E89 ABC transporter FE384_11785 ENOG4105E89 ABC transporter FE384_11790 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase FE384_11795 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase FE384_11800 ENOG4105E96 Colicin v production protein FE384_11805 ENOG4108S3P Sporulation domain protein FE384_11810 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase FE384_11820 ENOG4105DQR SNARE associated Golgi FE384_11830 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) FE384_11840 ENOG4106WZ1 flagella biosynthesis regulator FE384_11845 ENOG4105F9N Major Facilitator Superfamily FE384_11850 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) FE384_11855 ENOG4105CWG Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity) FE384_11860 ENOG4105MH2 YfcL protein FE384_11865 ENOG4108BPE -transporting atpase FE384_11870 ENOG4105EJ9 Membrane FE384_11885 ENOG4105C76 Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity) FE384_11900 ENOG4105US4 fimbrial-like protein yfcP FE384_11905 ENOG4105UGQ Fimbrial FE384_11910 ENOG4105NEV Fimbrial FE384_11915 ENOG4108FZ9 Chaperone FE384_11930 ENOG4108BY2 phosphohistidine phosphatase FE384_11945 ENOG4105KZW UPF0381 protein FE384_11950 ENOG4105CKF membrane protein involved in aromatic hydrocarbon degradation FE384_11960 ENOG410903C (LipO)protein FE384_11965 ENOG4105S64 Formate nitrite transporter FE384_11975 ENOG4105DFP Integrase FE384_11980 ENOG4105IHM Involved in O antigen modification. Involved in the translocation of bactoprenol-linked glucose across the cytoplasmic membrane (By similarity) FE384_11985 ENOG4105CKK Glycosyl transferase, family 2 FE384_12005 ENOG4105PTU response to oxidative stress FE384_12025 ENOG4105YQ0 FE384_12030 ENOG4105H40 FE384_12035 ENOG4108HJ1 Uncharacterized conserved protein (DUF2303) FE384_12040 ENOG4108R7K Metal Dependent Phosphohydrolase FE384_12045 ENOG41077V0 CPS-53 (KpLE1) prophage FE384_12055 ENOG41065VV Transcription inhibitory protein for the torCAD operon. Also acts as an excisionase and plays an essential role in the defective prophage CPS53 excision FE384_12060 ENOG4105W8I Transcriptional regulator FE384_12065 ENOG4105C6Z Gluconate FE384_12075 ENOG4105C0R drug resistance transporter emrb qaca subfamily FE384_12080 ENOG4105CW7 secretion protein, HlyD family FE384_12085 ENOG4108WQH regulatoR FE384_12090 ENOG4105BZU Histidine kinase FE384_12095 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F FE384_12100 ENOG4108N2Y auxin Efflux FE384_12105 ENOG4105CFN oxalyl-CoA decarboxylase FE384_12115 ENOG4108V08 YfdX protein FE384_12125 ENOG4105W9M Membrane FE384_12130 ENOG4105D1S lipid A biosynthesis FE384_12140 ENOG4105CHM Aminotransferase FE384_12145 ENOG4108HRK Histidine kinase FE384_12150 ENOG4105DY9 regulatoR FE384_12155 ENOG4108CIP transcriptional regulator FE384_12160 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) FE384_12165 ENOG4105CN9 Peptidase m42 family protein FE384_12170 ENOG4105DC7 peptidase M24 FE384_12175 ENOG410863U PTS System FE384_12180 ENOG4105R6B The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane (By similarity) FE384_12190 ENOG4105VCT ion-transport protein YfeO FE384_12195 ENOG4109076 Conserved Protein FE384_12205 ENOG4105D9N nucleoside FE384_12210 ENOG4108SER Transposase FE384_12215 ENOG4108KMM Diguanylate cyclase FE384_12230 ENOG4105HZG regulatoR FE384_12235 ENOG4105GXM Putative transcription regulator (DUF1323) FE384_12270 ENOG4105CN8 Transcriptional regulator FE384_12280 ENOG4105EAA nucleoside FE384_12285 ENOG4107U5R The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity) FE384_12290 ENOG4108NFH Sugar hydrolase FE384_12295 ENOG4108M0I Transcriptional regulator FE384_12300 ENOG4105DHU Bile acid FE384_12305 ENOG4105VRT cytoplasmic protein FE384_12310 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) FE384_12325 ENOG4105C6T cysteine synthase FE384_12330 ENOG4105KZ7 phosphocarrier protein hpr FE384_12335 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) FE384_12340 ENOG4105C5Y PTS System FE384_12350 ENOG4105M0Y FE384_12355 ENOG4105WEC Molybdate metabolism regulator FE384_12360 ENOG4105C6T cysteine synthase FE384_12365 ENOG4108IJ6 ABC transporter FE384_12370 ENOG4105ECW sulfate abc transporter FE384_12375 ENOG4108I5D sulfate abc transporter FE384_12380 ENOG4108J2H Sulfate ABC transporter periplasmic sulfate-binding protein FE384_12385 ENOG4105I7Z Short-chain dehydrogenase reductase Sdr FE384_12400 ENOG4105C5Y PTS System FE384_12405 ENOG4107S1E Beta-lactamase FE384_12410 ENOG4105EZR dyp-type peroxidase family protein FE384_12415 ENOG4105E7K (LipO)protein FE384_12420 ENOG4105QZU Inner membrane protein YfeZ FE384_12425 ENOG4108R6G acetyltransferase FE384_12430 ENOG4108KNB n-acetylmuramoyl-l-alanine amidase FE384_12440 ENOG4108K3Z AraC family transcriptional regulator FE384_12445 ENOG4108X49 Ethanolamine utilization protein EutK FE384_12450 ENOG4106D67 ethanolamine utilization protein FE384_12460 ENOG4105CPD ethanolamine ammonia-lyase FE384_12465 ENOG4105DYY Reactivating factor for ethanolamine ammonia lyase FE384_12470 ENOG4105ENY Ethanolamine utilization protein eutH FE384_12475 ENOG4105C0A alcohol dehydrogenase FE384_12480 ENOG4107RWI ethanolamine utilization protein eutJ FE384_12485 ENOG4108EKI Dehydrogenase FE384_12490 ENOG4105WVM ethanolamine utilization protein EutN carboxysome structural protein Ccml FE384_12495 ENOG4105KNY Microcompartments protein FE384_12500 ENOG4107WUY phosphate acetyltransferase FE384_12505 ENOG4108PFF ethanolamine utilization cobalamin adenosyltransferase FE384_12510 ENOG4105NDK ethanolamine utilization protein FE384_12515 ENOG4106S4J ethanolamine utilization protein EutP FE384_12520 ENOG4108VJN May be involved in the formation of a specific microcompartment in the cell in which the metabolism of potentially toxic by-products takes place FE384_12525 ENOG4105C6K Malic enzyme FE384_12530 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) FE384_12535 ENOG4105CV1 Transketolase (EC 2.2.1.1) FE384_12540 ENOG4108PVD exported protein FE384_12545 ENOG4107VIJ nudix hydrolase FE384_12550 ENOG4105BZ8 glutamate synthase FE384_12555 ENOG4105BZU Histidine kinase FE384_12560 ENOG4105BZS acriflavin resistance protein FE384_12570 ENOG4105KUZ arsenate reductase FE384_12585 ENOG4106KED esterase YpfH FE384_12590 ENOG4105E0I Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP) (By similarity) FE384_12595 ENOG4105CGZ zinc metallopeptidase FE384_12605 ENOG4107EG0 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) FE384_12615 ENOG4105RH4 Glycine cleavage system transcriptional repressor FE384_12620 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen FE384_12625 ENOG4108MFN small subunit of hydrogenase-3, iron-sulfur protein (part of formate hydrogenlyase (FHL) complex) FE384_12630 ENOG4108JPZ Monovalent cation H antiporter subunit D FE384_12635 ENOG4107TDF Formate hydrogenlyase subunit 4 FE384_12640 ENOG4105D65 subunit l FE384_12645 ENOG4107WQX hydrogenase 4 membrane subunit FE384_12650 ENOG4108JPZ Monovalent cation H antiporter subunit D FE384_12655 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) FE384_12665 ENOG4105C47 NADH ubiquinone oxidoreductase 20 kda subunit FE384_12670 ENOG4105I6X formate hydrogenlyase maturation FE384_12675 ENOG4108JUA Transcriptional regulator FE384_12680 ENOG4105TMB Formate nitrite transporter FE384_12685 ENOG4105C02 permease FE384_12690 ENOG4105ERG peptidase m48, ste24p FE384_12695 ENOG4105K89 arsenate reductase FE384_12705 ENOG4105C2W permease FE384_12720 ENOG4108V3E phosphoribosylglycinamide formyltransferase FE384_12725 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) FE384_12730 ENOG4105C9X ppx gppa phosphatase FE384_12735 ENOG4105BZU Histidine kinase FE384_12740 ENOG41062G3 Protein of unknown function (DUF2633) FE384_12745 ENOG4108ZMA Outer membrane lipoprotein FE384_12750 ENOG41066DY Membrane FE384_12760 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) FE384_12770 ENOG4105VPD cellular component movement FE384_12780 ENOG4105CNE Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) FE384_12785 ENOG4105N21 Membrane FE384_12815 ENOG4108JQB penicillin-binding protein 1C FE384_12820 ENOG4105DN3 alpha-2-macroglobulin domain protein FE384_12825 ENOG4105KHC sulfurtransferase FE384_12830 ENOG4105YYA enhanced serine sensitivity protein SseB FE384_12840 ENOG4105WVQ Fe-S assembly protein IscX FE384_12845 ENOG4108ZIT Ferredoxin, 2FE-2S FE384_12865 ENOG4107XTC May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins FE384_12890 ENOG4107XM9 (LipO)protein FE384_12900 ENOG4105D8G Major Facilitator superfamily FE384_12905 ENOG4108W5M transcriptional regulator FE384_12910 ENOG4105FUY alpha subunit FE384_12935 ENOG4108SB3 DoxX Family FE384_12940 ENOG4108ZKT aldose 1-epimerase FE384_12945 ENOG4105CPQ Dehydrogenase FE384_12950 ENOG4105CNN ABC, transporter FE384_12955 ENOG4108F37 ATP-binding component of a transport system FE384_12960 ENOG4105FCA ABC transporter periplasmic-binding protein YphF FE384_12965 ENOG4107HQ7 repeat protein FE384_12970 ENOG4108NZE NAGC-like transcriptional regulator FE384_12980 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) FE384_12985 ENOG4108YZA Nitrogen regulatory protein pii FE384_12990 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family FE384_12995 ENOG4108SKK alpha helix protein FE384_13000 ENOG4107WP9 Histidine kinase FE384_13005 ENOG4107QIK phosphoribosylformylglycinamidine synthase FE384_13015 ENOG4108Z6B deaminase FE384_13020 ENOG4105HYY HAD superfamily (Subfamily IF) hydrolase, YfhB FE384_13025 ENOG4106G6Q Transcriptional regulator FE384_13030 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding FE384_13045 ENOG4105CSZ Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity) FE384_13065 ENOG4105C3F Signal peptidase i FE384_13075 ENOG4105WMJ Positive regulator of sigma E, RseC MucC FE384_13080 ENOG4105VQK sigma E regulatory protein, MucB RseB FE384_13085 ENOG41069PW sigma-e factor negative regulatory protein FE384_13090 ENOG4105EMN RNA polymerase sigma factor FE384_13100 ENOG4108IYU L-aspartate oxidase FE384_13105 ENOG4107S47 Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC) (By similarity) FE384_13110 ENOG4105C1J atp-dependent rna helicase FE384_13115 ENOG41090KR LysR family transcriptional Regulator FE384_13135 ENOG4105EIB trna rrna methyltransferase FE384_13140 ENOG4105K63 Thioredoxin FE384_13145 ENOG4106IUH DTW domain containing protein FE384_13150 ENOG4105CD5 CoA-binding domain protein FE384_13155 ENOG4105JIM Phosphatidylserine synthase FE384_13160 ENOG4105T42 (LipO)protein FE384_13165 ENOG4105CSH Transporter FE384_13190 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit FE384_13195 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase FE384_13200 ENOG4105C34 Pseudouridine synthase FE384_13205 ENOG4106SNF Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane FE384_13210 ENOG4108WPH sigma 54 modulation protein ribosomal protein S30EA FE384_13220 ENOG4105CQC Prephenate dehydratase FE384_13225 ENOG4105EHE chorismate mutase- prephenate dehydrogenase FE384_13230 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) FE384_13235 ENOG4105QP9 Protein of unknown function (DUF2799) FE384_13240 ENOG4108WS1 FE384_13245 ENOG4108KHX Diguanylate cyclase FE384_13250 ENOG41090EK ompa motb domain protein FE384_13275 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY FE384_13280 ENOG4106KVJ cytochrome C assembly protein FE384_13285 ENOG4108JU6 CBS domain protein FE384_13300 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) FE384_13305 ENOG4105YRI Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) FE384_13310 ENOG4105VDB UPF0125 protein FE384_13315 ENOG4108Z1B Cyclase dehydrase FE384_13330 ENOG4105DFP Integrase FE384_13335 ENOG4106QCB CP4-57 prophage FE384_13340 ENOG410679B prophage CP4-57 regulatory protein alpA FE384_13345 ENOG4108P8R FE384_13350 ENOG4105H5P transposase FE384_13355 ENOG4107UNZ domain protein FE384_13360 ENOG4105JPW Domain of unknown function (DUF1837) FE384_13365 ENOG4107NPW Protein of unknown function (DUF1524) FE384_13370 ENOG4106K8T Toxic component of a toxin-antitoxin (TA) module. A stable (half-life 27.6 minutes) endoribonuclease that in the absence of cognate antitoxin RnlB causes generalized RNA degradation. Degrades late enterobacteria phage T4 mRNAs, protecting the host against T4 reproduction. Activity is inhibited by cognate antitoxin RnlB and by enterobacteria phage T4 protein Dmd. Targets cyaA mRNA FE384_13375 ENOG4106BHJ Antitoxin component of a toxin-antitoxin (TA) module. A labile antitoxin (half-life of 2.1 minutes) that inhibits the endonuclease activity of cognate toxin RnlA but not that of non- cognate toxin LsoA FE384_13380 ENOG4105TS0 gtp-binding protein FE384_13385 ENOG4106H6R UPF0380 protein FE384_13390 ENOG4108KZE transcriptional regulator FE384_13405 ENOG4106J9S Prophage FE384_13430 ENOG4105MFG Antirestriction protein FE384_13435 ENOG4108XS9 dna repair protein FE384_13445 ENOG4105MAW Antitoxin component of a toxin-antitoxin (TA) module. Labile antitoxin that counteracts the effect of the CbtA (YeeV) toxin. It does not bind to the cognate toxin but instead binds to MreB and FtsZ (the toxin targets), enhancing their polymerization by forming higher-order bundles FE384_13450 ENOG4108X3P Toxic component of a toxin-antitoxin (TA) module. Overexpression results in inhibition of growth in liquid cultures FE384_13455 ENOG4108MGN ATP-binding component of a transport system FE384_13495 ENOG4105D5U fad dependent oxidoreductase FE384_13500 ENOG4105C26 Dehydrogenase FE384_13505 ENOG4108JPW Aminotransferase FE384_13510 ENOG4105C85 amino acid FE384_13515 ENOG4108PVQ transcriptional regulator FE384_13520 ENOG4109066 lysm domain bon superfamily protein FE384_13525 ENOG4105VPI YqaE family transport protein FE384_13530 ENOG41080HT Transcriptional regulator, arsr family FE384_13535 ENOG4108V62 Rhodanese domain protein FE384_13540 ENOG4108X73 DNA- binding protein FE384_13545 ENOG4108RNS Exports L-alanine (By similarity) FE384_13550 ENOG4108WMJ Protein of unknown function (DUF2002) FE384_13555 ENOG4108ZQZ Bacterial protein of unknown function (DUF883) FE384_13560 ENOG4105WAZ (Glutaredoxin-like protein) NrdH FE384_13565 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) FE384_13570 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) FE384_13575 ENOG4107R25 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) FE384_13580 ENOG4108IJ7 Glycine betaine FE384_13585 ENOG4108HQS Glycine betaine FE384_13590 ENOG4105GIJ Glycine betaine FE384_13600 ENOG4108UMN azlc family FE384_13605 ENOG4105ZED uncharacterized protein ygaH FE384_13610 ENOG4105NTK Transcriptional repressor Mpra FE384_13615 ENOG4105CW7 secretion protein, HlyD family FE384_13620 ENOG4105C0R drug resistance transporter emrb qaca subfamily FE384_13635 ENOG4105W39 Membrane FE384_13640 ENOG4107VXZ Hydrolase FE384_13670 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) FE384_13675 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) FE384_13690 ENOG4107TH8 cina domain protein FE384_13695 ENOG4105CVE Lytic murein transglycosylase FE384_13700 ENOG410787A Pts system, glucitol sorbitol-specific FE384_13710 ENOG4105VI0 Pts system, glucitol sorbitol-specific FE384_13715 ENOG4107QMF Sorbitol-6-phosphate dehydrogenase FE384_13720 ENOG4105J92 DNA-binding transcriptional activator GutM FE384_13725 ENOG410804X Transcriptional regulator FE384_13730 ENOG4105C2X Arabinose 5-phosphate isomerase FE384_13740 ENOG4108ESE uses NADH to detoxify nitric oxide (NO), protecting several 4Fe-4S NO-sensitive enzymes. Has at least 2 reductase partners, only one of which (NorW, flavorubredoxin reductase) has been identified. NO probably binds to the di-iron center FE384_13750 ENOG4105C8H hydrogenase maturation protein Hypf FE384_13755 ENOG4108RC0 Electron transport protein FE384_13760 ENOG4105DDV Transcriptional regulator (LacI family FE384_13765 ENOG4105C5Y PTS System FE384_13770 ENOG4105CS2 ec 3.2.1.21 FE384_13775 ENOG4108MG9 hydrogenase 3 maturation protease FE384_13780 ENOG4105I6X formate hydrogenlyase maturation FE384_13785 ENOG4105C47 NADH ubiquinone oxidoreductase 20 kda subunit FE384_13790 ENOG4108RG7 formate hydrogenlyase complex iron-sulfur subunit FE384_13795 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) FE384_13800 ENOG4107TDF Formate hydrogenlyase subunit 4 FE384_13805 ENOG4107R30 NADH dehydrogenase FE384_13810 ENOG4108MFN small subunit of hydrogenase-3, iron-sulfur protein (part of formate hydrogenlyase (FHL) complex) FE384_13815 ENOG4108VRC Formate hydrogenlyase regulatory protein hycA FE384_13825 ENOG410816D Probably plays a role in a hydrogenase nickel cofactor insertion step (By similarity) FE384_13830 ENOG4107RSS Hydrogenase accessory protein HypB FE384_13835 ENOG41083WG hydrogenase assembly chaperone FE384_13840 ENOG4105CQS hydrogenase expression formation protein HypD FE384_13845 ENOG4105C45 hydrogenase expression formation protein (HypE) FE384_13850 ENOG4108JUA Transcriptional regulator FE384_13855 ENOG4105VXR cytoplasmic protein FE384_13865 ENOG4105MEW serine threonine protein phosphatase FE384_13870 ENOG4105MVE transcriptional regulator FE384_13875 ENOG4105ZXK Dehydrogenase FE384_13880 ENOG4105G63 Type III effector Hrp-dependent FE384_13885 ENOG4105FB2 class II Aldolase FE384_13890 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) FE384_13895 ENOG4105C6Z Gluconate FE384_13905 ENOG4108K5P (LipO)protein FE384_13940 ENOG4105N0Z inner membrane protein ygbE FE384_13960 ENOG4108MXK alkaline phosphatase isozyme conversion FE384_13965 ENOG4105PWE CRISPR-associated protein cas2 FE384_13970 ENOG4105TZK CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. May be involved in the integration of spacer DNA into the CRISPR cassette (By similarity) FE384_13975 ENOG4108Y7V CRISPR-associated protein, Cse3 family FE384_13980 ENOG4108VWQ crispr-associated protein FE384_13985 ENOG41060M0 Crispr-associated protein, cse4 family FE384_13990 ENOG41061HK CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA) FE384_13995 ENOG4105CYR Crispr-associated protein, cse1 family FE384_14000 ENOG4105DTT CRISPR-associated helicase, cas3 FE384_14020 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) FE384_14025 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase FE384_14030 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase FE384_14035 ENOG4105WQV ferredoxin-like protein FE384_14040 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator FE384_14045 ENOG4105YBM electron transfer flavoprotein subunit ygcQ FE384_14050 ENOG4106IKH Electron transfer flavoprotein FE384_14055 ENOG4105C54 Major Facilitator superfamily FE384_14060 ENOG4107R3A FAD linked oxidase domain protein FE384_14065 ENOG4105CHR reductase FE384_14070 ENOG4108ITV Inner membrane protein yqcE FE384_14075 ENOG4108CWB sugar kinase ygcE FE384_14080 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) FE384_14090 ENOG4105HA9 of methanol dehydrogenase type FE384_14105 ENOG4105DXN mazG family FE384_14110 ENOG4105MZG transcriptional modulator of maze toxin, mazf FE384_14115 ENOG4106A2Z transcriptional regulator antitoxin, MazE FE384_14120 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) FE384_14125 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) FE384_14130 ENOG4105BZU Histidine kinase FE384_14135 ENOG4105EQX glucarate dehydratase FE384_14140 ENOG4105EQX glucarate dehydratase FE384_14145 ENOG4105DJB Major Facilitator Superfamily FE384_14150 ENOG4105QDK Flavodoxin FE384_14155 ENOG4105DR9 pseudouridine synthase FE384_14160 ENOG4105WP7 tRNA pseudouridine synthase C FE384_14175 ENOG4105EWT decarboxylase family FE384_14180 ENOG4105C44 Serine transporter FE384_14185 ENOG4105EJQ L-serine dehydratase FE384_14195 ENOG4105C0A alcohol dehydrogenase FE384_14200 ENOG4107W7X Aldolase FE384_14215 ENOG4105CMG Carbohydrate kinase FE384_14225 ENOG4107EDW L-fucose operon activator FE384_14235 ENOG4105M08 Membrane FE384_14240 ENOG4105ETT transcriptional Regulator, LysR family FE384_14245 ENOG4105M5B (LipO)protein FE384_14250 ENOG4105C9B Cysteine desulfurase FE384_14255 ENOG4105P9C Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity) FE384_14260 ENOG4105CUZ uba thif-type nad fad binding protein FE384_14265 ENOG4105CA3 membrane-bound lytic murein transglycosylase FE384_14285 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase FE384_14290 ENOG4107QZM n-acetylglutamate synthase FE384_14295 ENOG4107QYX exodeoxyribonuclease v alpha FE384_14300 ENOG4107QKA exodeoxyribonuclease V beta FE384_14305 ENOG4107QXK peptidase FE384_14310 ENOG4105DSY exodeoxyribonuclease V, gamma FE384_14315 ENOG4105RVB Prepilin peptidase dependent protein c FE384_14320 ENOG4105SEN Protein of unknown function (DUF2509) FE384_14325 ENOG4105JCS prepilin peptidase dependent protein FE384_14330 ENOG4105IPU prepilin peptidase dependent protein A FE384_14345 ENOG4108HRM phosphoenolpyruvate--protein phosphotransferase FE384_14365 ENOG4105EE5 Membrane protein terC FE384_14370 ENOG4105SUV lipoprotein YgdR FE384_14375 ENOG4105CPC Aldo Keto reductase FE384_14395 ENOG41060NJ transcriptional regulator FE384_14400 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) FE384_14405 ENOG4105RQF LysR family Transcriptional regulator FE384_14410 ENOG4105CG9 aspartate racemase FE384_14415 ENOG4107QNK )-transporter FE384_14420 ENOG4105CHR reductase FE384_14430 ENOG4105CHU acetyl-coa acetyltransferase FE384_14435 ENOG4108MHD transport protein FE384_14440 ENOG4105ISV protein with bipartite regulator domain FE384_14445 ENOG4108TC1 Transcriptional regulator FE384_14450 ENOG4105FV3 FE384_14475 ENOG4108YAB Invasion protein FE384_14525 ENOG4108K5P (LipO)protein FE384_14530 ENOG4105C7W Xanthine dehydrogenase FE384_14535 ENOG4108HR6 Dehydrogenase FE384_14540 ENOG4108UTP (2Fe-2S)-binding domain protein FE384_14545 ENOG4108JUB Transcriptional regulator FE384_14550 ENOG4105IW6 Carbamoyltransferase FE384_14555 ENOG4107RCH Diaminopropionate ammonia-lyase FE384_14560 ENOG4107S4Y M20 DapE family protein YgeY FE384_14570 ENOG4105C5B carbamate kinase FE384_14575 ENOG4107P0T Selenium-dependent molybdenum hydroxylase system protein, YqeB family FE384_14580 ENOG4105MJ6 selenium-dependent hydroxylase accessory protein YqeC FE384_14585 ENOG4105MFX 4-diphosphocytidyl-2c-methyl-d-erythritol synthase FE384_14590 ENOG4105BZ8 glutamate synthase FE384_14595 ENOG4107UUR Chlorohydrolase aminohydrolase FE384_14600 ENOG410873Y FAD binding domain in molybdopterin dehydrogenase FE384_14605 ENOG4105C7W Xanthine dehydrogenase FE384_14610 ENOG4105C2W permease FE384_14615 ENOG4107QUY Guanine deaminase FE384_14620 ENOG4105C7N Xanthine uracil vitamin C permease FE384_14625 ENOG4108R8B oxidoreductase Fe-S subunit FE384_14630 ENOG4105BZ8 glutamate synthase FE384_14635 ENOG4105C2W permease FE384_14655 ENOG4105CRK lysyL-tRNA synthetase FE384_14665 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) FE384_14670 ENOG4105T95 Thiol disulfide interChange protein FE384_14675 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) FE384_14680 ENOG41071R3 Low-potential electron donor to a number of redox enzymes (By similarity) FE384_14685 ENOG4108YDB Toxic component of a toxin-antitoxin (TA) module. Overexpression leads to growth arrest after 5 hours, with initial elongation of cells, followed by swelling. The toxic effects are abrogated by coexpression with antitoxin CptB. Interacts with cytoskeletal proteins FtsZ and MreB FE384_14690 ENOG4105Y75 tpr repeat protein FE384_14700 ENOG4108UT2 hemolysin iii FE384_14705 ENOG4105N5Z UPF0267 protein FE384_14710 ENOG4105CS2 ec 3.2.1.21 FE384_14715 ENOG4105CYX Short-chain dehydrogenase reductase Sdr FE384_14740 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family FE384_14745 ENOG4105D0A hydroxylase FE384_14750 ENOG4107RAQ aminopeptidase FE384_14770 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase FE384_14780 ENOG4108JQ1 Dehydrogenase FE384_14800 ENOG4105D5P Methylmalonyl-coA mutase FE384_14805 ENOG4105DJT lAO AO transport system ATPase FE384_14810 ENOG4108M7F enoyl-CoA hydratase isomerase FE384_14815 ENOG4105CYC Transferase FE384_14820 ENOG4105DEQ transcriptional regulator FE384_14825 ENOG4105MPN Membrane FE384_14830 ENOG4108ZUB Lysine exporter protein (Lyse ygga) FE384_14835 ENOG4105D64 Mechanosensitive ion channel FE384_14840 ENOG4105D2N Aldolase FE384_14855 ENOG4107Z1W Fructose transport system kinase FE384_14860 ENOG4108R4K DNA-binding, transcriptional regulator FE384_14865 ENOG4108Q8A Fructose-1,6-bisphosphatase FE384_14870 ENOG4105DXH Alcohol dehydrogenase zinc-binding domain protein FE384_14875 ENOG4105CTS PTS system mannitol-specific FE384_14880 ENOG4108X7Y Mannitol-specific cryptic phosphotransferase enzyme iia FE384_14885 ENOG4105CV1 Transketolase (EC 2.2.1.1) FE384_14890 ENOG4108K0D peptidase, M48 FE384_14900 ENOG4105DP5 Catalyzes the biosynthesis of agmatine from arginine (By similarity) FE384_14915 ENOG4107QNK )-transporter FE384_14925 ENOG4105RWS endonuclease I FE384_14930 ENOG4105QF0 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) FE384_14935 ENOG4105D7Z glutathione synthase FE384_14950 ENOG4105CZX twitching motility protein FE384_14955 ENOG4105DFA alanine racemase domain protein FE384_14960 ENOG4108VIA integral membrane protein FE384_14970 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) FE384_14975 ENOG4105CSA Coproporphyrinogen iii oxidase FE384_14980 ENOG4106MH3 alpha helix chain FE384_14985 ENOG4105HDK L-asparaginase FE384_14990 ENOG4105K33 Periplasmic Protein FE384_14995 ENOG41090ED Protein with unknown function (DUF469) FE384_15005 ENOG4105CEN a g-specific adenine glycosylase FE384_15020 ENOG4105EAA nucleoside FE384_15025 ENOG4105CXN decarboxylase FE384_15030 ENOG4108UQV Membrane FE384_15040 ENOG4105U1E general secretion pathway protein M FE384_15050 ENOG4108XKW General secretion pathway protein C FE384_15055 ENOG410765S (LipO)protein FE384_15060 ENOG4105EHH Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue (By similarity) FE384_15065 ENOG4105F88 accessory colonization factor AcfD FE384_15070 ENOG4105DAA L-lactate FE384_15075 ENOG4107QP3 malate synthase g FE384_15080 ENOG4108ZJF Glcg protein FE384_15085 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) FE384_15090 ENOG4105EU8 FAD linked oxidase domain protein FE384_15095 ENOG4105CQB FAD linked oxidase domain protein FE384_15100 ENOG4108KWP DNA-binding transcriptional regulator GlcC FE384_15110 ENOG4105F2I Transposase FE384_15115 ENOG4108S55 polysaccharide biosynthesis protein FE384_15120 ENOG4106FPV ATP-binding protein YghR FE384_15125 ENOG4108NDC ATP-binding protein yghS FE384_15130 ENOG4108GH0 ATP-binding protein yghT FE384_15135 ENOG4105CJ3 phosphate transporter FE384_15140 ENOG4106032 Glutathionylspermidine synthase FE384_15145 ENOG4105CYM Glutathione S-transferase FE384_15150 ENOG41082MF Hydrogenase assembly chaperone hypC hupF FE384_15155 ENOG4105WMM Probably plays a role in a hydrogenase nickel cofactor insertion step (By similarity) FE384_15160 ENOG4108WGS hydrogenase 2-specific chaperone FE384_15165 ENOG4108USZ hydrogenase FE384_15170 ENOG4105DPX Hydrogenase, large subunit FE384_15175 ENOG4105CJ5 hydrogenase 2 b cytochrome subunit FE384_15180 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein FE384_15185 ENOG4105E3S small subunit FE384_15190 ENOG410900S Protein of unknown function (DUF2623) FE384_15200 ENOG4105CPC Aldo Keto reductase FE384_15210 ENOG4105CYX Short-chain dehydrogenase reductase Sdr FE384_15215 ENOG4108ZZF transport protein (ExbD) FE384_15220 ENOG4105CWK Biopolymer transport protein, ExbB FE384_15225 ENOG4105C28 cystathionine FE384_15230 ENOG4108K81 inner membrane protein YghB FE384_15235 ENOG4105CF7 AraC family transcriptional regulator FE384_15240 ENOG4108I6A alcohol dehydrogenase FE384_15245 ENOG4105CV8 reductase FE384_15250 ENOG4105ZKC Conserved Protein FE384_15260 ENOG4105CCT upf0313 protein FE384_15265 ENOG4107TZ2 Cell division protein that is required for growth during stress conditions. May be involved in protecting or stabilizing the divisomal assembly under conditions of stress (By similarity) FE384_15270 ENOG4107S7E 1-acyl-sn-glycerol-3-phosphate acyltransferase FE384_15275 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) FE384_15280 ENOG4108J59 Extracellular solute-binding protein, family 5 FE384_15285 ENOG4105WJ3 XRE family Transcriptional regulator FE384_15290 ENOG4105RT5 Toxic component of a toxin-antitoxin (TA) module. An mRNA interferase which has been reported to be translation- independent (PubMed 19690171, PubMed 19943910) and translation- dependent (PubMed 20041169). Cleavage has been reported to occur on either side of G in the sequence GCU (PubMed 19690171) but also after C in GC(A U) sequences (PubMed 19943910). There are only 14 genes in E.coli W3110 (and probably also MG1655) that do not have a GCU sequence and thus are resistant to the mRNA interferase activity. Overexpression causes cessation of cell growth and inhibits cell proliferation via inhibition of translation as well as increasing persister cell formation FE384_15295 ENOG4105F4I Transcriptional regulator FE384_15300 ENOG4105H4F exported protein FE384_15305 ENOG4105XJC Two component transcriptional regulator (Winged helix family FE384_15310 ENOG4105DHQ Histidine kinase FE384_15315 ENOG4107DEU Inner membrane protein YgiZ FE384_15320 ENOG4105NF4 modulator of drug activity FE384_15325 ENOG4105VRH Antibiotic biosynthesis monooxygenase FE384_15330 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) FE384_15335 ENOG4105IPS esterase FE384_15340 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) FE384_15345 ENOG4108SX3 cytoplasmic protein FE384_15350 ENOG41087AY ADP-Ribose pyrophosphatase FE384_15355 ENOG4105DFG type I secretion outer membrane protein FE384_15365 ENOG4106032 Glutathionylspermidine synthase FE384_15370 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b FE384_15385 ENOG4105W0Z cytoplasmic protein FE384_15390 ENOG4105H8W Fimbrial protein FE384_15405 ENOG4108TTM chaperone FE384_15410 ENOG4108MY7 Fimbrial FE384_15420 ENOG4105PV3 Inner membrane protein yqiJ FE384_15425 ENOG4107S78 Band 7 protein FE384_15450 ENOG4105I7R Adenylate cyclase FE384_15455 ENOG4106MWK domain protein FE384_15465 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) FE384_15470 ENOG4107ZVW dihydroneopterin aldolase FE384_15480 ENOG4105EJC lysr family transcriptional regulator FE384_15485 ENOG4106DSS Tartrate dehydratase subunit alpha FE384_15490 ENOG4107GFK fumarate FE384_15495 ENOG4107QPK )-transporter FE384_15505 ENOG4105VCC 30S ribosomal protein S21 FE384_15510 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) FE384_15515 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FE384_15530 ENOG4105Q26 Siderophore-interacting protein FE384_15535 ENOG4105NTW Transcriptional regulator FE384_15540 ENOG4107RHT methyl-accepting chemotaxis sensory transducer with Pas Pac sensor FE384_15550 ENOG4108Y51 tRNA-binding protein FE384_15555 ENOG4105CQ4 Transcriptional regulator FE384_15560 ENOG4105CNT hydrolase family 2 FE384_15565 ENOG4105FK9 beta-D-galactosidase beta subunit FE384_15570 ENOG4105E5D amino acid FE384_15575 ENOG4107W6W Conserved Protein FE384_15580 ENOG4107WCA isomerase FE384_15585 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase FE384_15590 ENOG4108Z3N Transcriptional regulator FE384_15595 ENOG4105R48 this blockage is overcome by subsequent expression of antitoxin HigA. Overexpression causes cleavage of a number of mRNAs in a translation-dependent fashion, suggesting this is an mRNA interferase FE384_15600 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) FE384_15605 ENOG4108VKG metal-dependent hydrolase FE384_15610 ENOG4108UB4 uncharacterized protein ygjQ FE384_15615 ENOG4105EE0 oxidoreductase FE384_15620 ENOG4105DU1 integral membrane protein, terc FE384_15625 ENOG4107QV7 Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system) (By similarity) FE384_15630 ENOG4105P66 Membrane FE384_15635 ENOG4105CTX dehydratase FE384_15645 ENOG4105DPW Major facilitator superfamily MFS_1 FE384_15650 ENOG4107YCY Transcriptional regulator FE384_15655 ENOG4106W5V Membrane FE384_15660 ENOG4105IYR Modulates the activity of the EnvZ OmpR two-component regulatory system, probably by directly modulating EnvZ enzymatic activity and increasing stability of phosphorylated OmpR (By similarity) FE384_15665 ENOG4105WAY exported protein FE384_15670 ENOG4105NE1 Conserved Protein FE384_15675 ENOG41090KG Inner membrane protein YqjE FE384_15680 ENOG4105YJD FE384_15685 ENOG4108VBZ doxx family FE384_15690 ENOG4105CHF Glutathione S-transferase FE384_15695 ENOG4105KAF membrAne FE384_15700 ENOG4105KAF membrAne FE384_15705 ENOG4105CWB LysR family transcriptional Regulator FE384_15710 ENOG4108CNN domain protein FE384_15715 ENOG4106D80 Uncharacterized protein YhaL FE384_15725 ENOG4105C44 Serine transporter FE384_15730 ENOG4105EJQ L-serine dehydratase FE384_15735 ENOG4105KME endoribonuclease L-psp FE384_15740 ENOG4105C6N Formate acetyltransferase FE384_15745 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) FE384_15755 ENOG4105C7B Threonine dehydratase FE384_15760 ENOG410811B TRANSCRIPTIONal FE384_15785 ENOG4105BZW Glycerate kinase FE384_15790 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase FE384_15800 ENOG4105DJB Major Facilitator Superfamily FE384_15805 ENOG4105CTX dehydratase FE384_15810 ENOG4105ZEG Suppressor protein FE384_15815 ENOG4108R8Z these effects are overcome by concomitant expression of antitoxin SohA (PrlF). Massive overexpression is toxic. Unlike most other characterized TA systems degrades rRNA, and co-folding of the proteins is necessary in vitro for inhibition of the RNase activity. It is not known if it has any sequence-specificity. Acts as a transcription factor. The YhaV PrlF complex binds the prlF-yhaV operon, probably negatively regulating its expression FE384_15820 ENOG4105E98 transcriptional regulator DeoR family FE384_15830 ENOG4108RG5 PTS system N-acetylgalactosamine-specific transporter subunit IIB FE384_15845 ENOG4105E70 isomerase FE384_15855 ENOG4108UZY PTS System FE384_15860 ENOG4105ETZ PTS System FE384_15865 ENOG4105F3R pts system mannose fructose sorbose family iid FE384_15870 ENOG4106HBN Galactosamine-6-phosphate isomerase FE384_15875 ENOG4105Q10 Fimbrial-like protein FE384_15880 ENOG4108VCD Chaperone FE384_15885 ENOG4105CW0 outer membrane usher protein FE384_15890 ENOG4105I74 Fimbrial protein FE384_15895 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) FE384_15900 ENOG4105E1C Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1A (PBP1a) (By similarity) FE384_15910 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) FE384_15915 ENOG4105W4M Transport-associated protein FE384_15920 ENOG4107S21 permease FE384_15925 ENOG4105K4T epimerase FE384_15930 ENOG4107R7Y intracellular protease Pfpi family FE384_15945 ENOG4108YYD acetyltransferase FE384_15950 ENOG4105XPQ lipid carrier protein FE384_15955 ENOG4105CFP Peptidase U32 FE384_15960 ENOG4106RZ4 Peptidase U32 FE384_15965 ENOG4105DEN Luciferase family FE384_15970 ENOG4105CIC tryptophan-specific transport protein FE384_15975 ENOG4105C1J atp-dependent rna helicase FE384_15985 ENOG4105RT1 May be involved in cell division (By similarity) FE384_16000 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) FE384_16015 ENOG4105CHV Transcription elongation factor NusA FE384_16035 ENOG4105DIJ Phosphoethanolamine transferase FE384_16055 ENOG4105EEI dihydropteroate synthase FE384_16060 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) FE384_16065 ENOG4105F7M Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit (By similarity) FE384_16070 ENOG4105HBR Rna-binding protein FE384_16075 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) FE384_16080 ENOG4106HRJ d-alanyl-d-alanine carboxypeptidase FE384_16085 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control FE384_16090 ENOG4105QYV Membrane FE384_16105 ENOG4105EAH synthase FE384_16110 ENOG4105HVQ Regulatory factor of maltose metabolism FE384_16120 ENOG4105VFK BolA family FE384_16125 ENOG4105UE2 Part of the ABC transporter complex MlaFEDB that actively prevents phospholipid accumulation at the cell surface. Probably maintains lipid asymmetry in the outer membrane by retrograde trafficking of phospholipids from the outer membrane to the inner membrane FE384_16130 ENOG4105E3I toluene tolerance FE384_16135 ENOG4107PE3 Mammalian cell entry related domain protein FE384_16140 ENOG4105CY3 ABC transporter, permease FE384_16145 ENOG4105DHJ ABC, transporter FE384_16150 ENOG4105FEU K -dependent Na -Ca exchanger FE384_16155 ENOG4105C2X Arabinose 5-phosphate isomerase FE384_16160 ENOG4108Z4R 3-deoxy-d-manno-octulosonate 8-phosphate phosphatase FE384_16165 ENOG4108P1K Required for the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane (By similarity) FE384_16170 ENOG4105WI0 lipopolysaccharide transport periplasmic protein lptA FE384_16175 ENOG4108IUZ ABC transporter FE384_16180 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FE384_16185 ENOG41080QH sigma 54 modulation protein ribosomal protein S30EA FE384_16190 ENOG4107RM2 PTS IIA-like nitrogen-regulatory protein PtsN FE384_16200 ENOG41080Z8 PHOSPHOCARRIER protein FE384_16205 ENOG4108NIH transferase activity, transferring phosphorus-containing groups FE384_16215 ENOG4108556 Isoprenoid biosynthesis protein with amidotransferase-like domain FE384_16220 ENOG4105BZU Histidine kinase FE384_16225 ENOG4105N5T Radical SAM Protein FE384_16230 ENOG4105CBC glutamate synthase FE384_16235 ENOG4105BZ8 glutamate synthase FE384_16240 ENOG4106AJS Involved in induction of the so-called NTR enzymes in response to nitrogen deprivation, as well as in glutamate biosynthesis. May mediate the glutamate-dependent repression of the GLT operon FE384_16245 ENOG4108S1B Periplasmic chaperone protein FE384_16250 ENOG4105E6S usher protein( FE384_16260 ENOG4105F2I Transposase FE384_16265 ENOG4105UMR response to DNA damage stimulus FE384_16270 ENOG4105DFS Conserved Protein FE384_16275 ENOG4108R66 Conserved Protein FE384_16310 ENOG4105KB2 stringent starvation protein b FE384_16315 ENOG4107MKT Stringent starvation protein a FE384_16320 ENOG4108UJD 30S ribosomal protein S9 FE384_16330 ENOG4105D6Z AFG1 family ATPase FE384_16335 ENOG4108W2Q Cytochrome d ubiquinol oxidase subunit III FE384_16340 ENOG4105C0H protease FE384_16345 ENOG4105C0H protease FE384_16360 ENOG4105RID UPF0379 protein yhcN FE384_16365 ENOG4105UNR (Barnase) inhibitor FE384_16385 ENOG4105CR8 Transcriptional regulator FE384_16390 ENOG4105D1U peptidase U62 modulator of DNA gyrase FE384_16395 ENOG4105QD6 exported protein FE384_16400 ENOG4105C03 ribonuclease FE384_16405 ENOG4108Z03 MAF-like protein FE384_16410 ENOG4105VQ7 Rod shape-determining protein MreD FE384_16415 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) FE384_16420 ENOG4105DFF Rod shape-determining protein mreb FE384_16425 ENOG41062P1 Diguanylate cyclase phosphodiesterase FE384_16430 ENOG4105D3Z quinone oxidoreductase, yhdh yhfp family FE384_16435 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein FE384_16440 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase FE384_16445 ENOG4105RG0 Membrane FE384_16450 ENOG4108IA2 Sodium pantothenate symporter FE384_16460 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) FE384_16465 ENOG4105VY0 Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters (By similarity) FE384_16470 ENOG4105CEC DNA methylase N-4 N-6 FE384_16475 ENOG41061ME transport protein FE384_16480 ENOG4108XG4 DNA-binding transcriptional regulator FE384_16485 ENOG4105C1P efflux transporter, rnd family, mfp subunit FE384_16490 ENOG4105BZS acriflavin resistance protein FE384_16495 ENOG4105XCM membrane LIPOPROTEIN FE384_16505 ENOG4105EZ7 amino acid ABC transporter FE384_16510 ENOG4105DRP amino acid AbC transporter FE384_16515 ENOG4105CDA abc transporter atp-binding protein FE384_16560 ENOG4108Z0R Transferase FE384_16565 ENOG4105SG3 Protein of unknown function (DUF1488) FE384_16575 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) FE384_16580 ENOG4108WI1 Dna topoisomerase FE384_16590 ENOG4105C79 DNA protecting protein DprA FE384_16610 ENOG4105C1A potassium transporter peripheral membrane FE384_16620 ENOG4105VCN Rescues the ribosomes stalled at the 3' end of non-stop mRNAs. May induce hydrolysis of the ribosome-bound peptidyl-tRNA. This activity is crucial when the stalled ribosome can not be rescued by the SsrA(tmRNA)-SmpB quality control system FE384_16625 ENOG4105W1Y Transcriptional regulator FE384_16630 ENOG4105VTS DnaJ-like, subfamily C FE384_16640 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) FE384_16645 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) FE384_16655 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits FE384_16660 ENOG41067V7 50S ribosomal protein L36 FE384_16665 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) FE384_16680 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) FE384_16685 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) FE384_16695 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) FE384_16710 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) FE384_16720 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal FE384_16730 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) FE384_16735 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) FE384_16740 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) FE384_16745 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) FE384_16755 ENOG41080KG One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) FE384_16760 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) FE384_16775 ENOG4107ACA Calcium-binding protein required for initiation of chromosome replication FE384_16780 ENOG410899B May play a regulatory role under conditions of derepressed gsp gene expression FE384_16785 ENOG4107KSE General secretion pathway protein C FE384_16790 ENOG4105GVR general secretion pathway protein D FE384_16795 ENOG4107QHF type ii secretion system protein e FE384_16800 ENOG4105D7Q type ii secretion system FE384_16805 ENOG4108VAU general secretion pathway protein G FE384_16810 ENOG41069X0 general secretion pathway protein h FE384_16825 ENOG4105R04 type II secretion system protein K FE384_16830 ENOG41063JA Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins (By similarity) FE384_16840 ENOG4105EHH Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue (By similarity) FE384_16845 ENOG4108UQY Iron-storage protein FE384_16850 ENOG4105W53 bacterioferritin-associated ferredoxin FE384_16855 ENOG4108NNZ chitinase FE384_16895 ENOG4105WWK YheO domain protein FE384_16900 ENOG4108V1T peptidylprolyl cis-trans isomerase FE384_16910 ENOG4108YZY peptidylprolyl cis-trans isomerase FE384_16915 ENOG4105VKU nucleicacid-binding protein FE384_16930 ENOG4105C5H ABC transporter FE384_16935 ENOG4105DNZ Alpha Beta Hydrolase FE384_16945 ENOG4105CJE phosphoribulokinase (EC 2.7.1.19) FE384_16950 ENOG4108UKZ OsmC family FE384_16955 ENOG4107RYR Transcriptional regulator, Crp Fnr family FE384_16960 ENOG410613R integral membrane protein, YccS YhfK family FE384_16965 ENOG4105C8Y Acetylornithine aminotransferase FE384_16970 ENOG4105DDQ anthranilate synthase FE384_16975 ENOG4105MZU cell filamentation protein FE384_16980 ENOG4106195 uncharacterized protein yhfG FE384_16985 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) FE384_16995 ENOG4107QZF nitrite reductase NADPH large subunit FE384_17000 ENOG4105WZK nitrite reductase NADPH small subunit FE384_17005 ENOG4107V9H nitrite transporter FE384_17015 ENOG4105VYH FE384_17020 ENOG4107QHQ amino acid FE384_17025 ENOG4107R1S catalyzes the conversion of fructoselysine 6-phosphate to glucose 6-phosphate and lysine FE384_17030 ENOG4107Y0V Not clear, may be involved in an isomerization step FE384_17035 ENOG4108KPW sugar kinase FE384_17040 ENOG4105FDP GntR family transcriptional regulator FE384_17045 ENOG4106PKC pyridoxal phosphate binding FE384_17050 ENOG4106M0N transport system permease protein FE384_17055 ENOG4105MUZ Protein of unknown function DUF2620 FE384_17060 ENOG41080QX K07048 phosphotriesterase-related protein FE384_17065 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) FE384_17070 ENOG4108626 Racemase FE384_17075 ENOG4105RMW regulation of transcription, DNA-dependent FE384_17080 ENOG4108M21 FE384_17090 ENOG4105C31 Tryptophanyl-tRNA synthetase FE384_17095 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) FE384_17100 ENOG4105DJV ribulose-phosphate 3-epimerase FE384_17105 ENOG4105DFE Dna adenine methylase FE384_17110 ENOG4105EGB membrane protein DamX FE384_17125 ENOG4105E4G Type IV pilus FE384_17130 ENOG4105ITY Required for the use of extracellular DNA as a nutrient FE384_17135 ENOG4105XPX DNA utilization protein HofO FE384_17140 ENOG41065NF Fimbrial assembly family protein FE384_17145 ENOG4108U1Q Pilus assembly protein FE384_17150 ENOG4108JQC penicillin-binding protein 1A FE384_17155 ENOG4107RK2 ADP-ribose diphosphatase NudE FE384_17160 ENOG4105DQY intracellular growth attenuator FE384_17165 ENOG4107Y3D HAD-superfamily hydrolase subfamily IA variant 3 FE384_17170 ENOG4105VEJ Heat shock protein FE384_17180 ENOG4108MAJ Membrane FE384_17190 ENOG4105E0F Histidine kinase FE384_17195 ENOG4105DPZ Two component transcriptional regulator (Winged helix family FE384_17200 ENOG4108RRZ Transcription elongation factor GreB FE384_17205 ENOG4105BZM domain protein FE384_17210 ENOG4105XFK Ferrous iron transport protein A FE384_17215 ENOG4105CE1 Ferrous iron transport protein b FE384_17225 ENOG4105DNE Transposase FE384_17235 ENOG4105MJ2 Competence protein FE384_17245 ENOG4105C6Z Gluconate FE384_17250 ENOG4107RTM 4-alpha-glucanotransferase (EC 2.4.1.25) FE384_17255 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) FE384_17270 ENOG4105E0Y RtcB Protein FE384_17275 ENOG4105CYB regulatoR FE384_17280 ENOG4105E98 transcriptional regulator DeoR family FE384_17295 ENOG4105C6V Glycerol-3-phosphate dehydrogenase FE384_17305 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) FE384_17330 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) FE384_17335 ENOG41076UM multiple antibiotic resistance (MarC)-related protein FE384_17340 ENOG4105C6Z Gluconate FE384_17345 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family FE384_17350 ENOG4105DIQ Transcriptional regulator FE384_17355 ENOG4105C2I pirin domain protein FE384_17360 ENOG4105D9R oxidoreductase FE384_17365 ENOG4105WCN acetyltransferase FE384_17370 ENOG4105GMB type VI secretion system effector, hcp1 family FE384_17395 ENOG4106FA4 FE384_17400 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) FE384_17405 ENOG4105WC8 Conserved Protein FE384_17410 ENOG4107T6V glycerophosphoryl diester phosphodiesterase FE384_17415 ENOG4108IJ9 (ABC) transporter FE384_17420 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component FE384_17425 ENOG4105E4X binding-protein-dependent transport systems inner membrane Component FE384_17430 ENOG4105BZ7 extracellular solute-binding protein family 1 FE384_17435 ENOG4108IV0 ABC, transporter FE384_17440 ENOG4105C0Z ABC transporter FE384_17445 ENOG4105CF8 branched-chain amino acid ABC transporter, permease FE384_17450 ENOG4105C32 Amino acid ABC transporter (Permease) FE384_17455 ENOG4105CP9 extracellular ligand-binding receptor FE384_17460 ENOG4105U59 -acetyltransferase FE384_17465 ENOG4105CP9 extracellular ligand-binding receptor FE384_17470 ENOG4105DEK Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) FE384_17475 ENOG4105CRP Part of the ABC transporter FtsEX involved in FE384_17480 ENOG4105CAK Cell division ATP-binding protein ftsE FE384_17485 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) FE384_17490 ENOG4106H78 methyltransferase FE384_17495 ENOG4105MG3 Membrane FE384_17505 ENOG4107FS9 Membrane FE384_17510 ENOG4105C59 p-type ATPase FE384_17520 ENOG4105EX9 Membrane FE384_17525 ENOG4108W1V Lipoprotein FE384_17530 ENOG4105F9N Major Facilitator Superfamily FE384_17535 ENOG4105DSF transport protein FE384_17540 ENOG4107YAK holo-(acyl carrier protein) synthase 2 FE384_17545 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein FE384_17550 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component FE384_17555 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FE384_17560 ENOG4106665 Part of the ABC transporter complex NikABCDE involved in nickel import. Responsible for energy coupling to the transport system (By similarity) FE384_17565 ENOG4105EFJ Part of the ABC transporter complex NikABCDE involved in nickel import. Responsible for energy coupling to the transport system (By similarity) FE384_17575 ENOG4105CNA YD repeat protein FE384_17585 ENOG4105NUP lyase containing HEAT-repeat FE384_17590 ENOG410600T transposase FE384_17595 ENOG4105CMI transporter FE384_17600 ENOG4105CJ1 ABC, transporter FE384_17605 ENOG4105D0S secretion protein (HlyD FE384_17620 ENOG4107UNS conserved inner membrane protein FE384_17625 ENOG4105CBX hi0933 family FE384_17630 ENOG4105CJ3 phosphate transporter FE384_17640 ENOG4108M6U Universal stress protein A FE384_17645 ENOG4105DUX Transporter FE384_17650 ENOG4105FFN Specifically methylates the guanosine in position 1516 of 16S rRNA (By similarity) FE384_17655 ENOG4105DGW oligopeptidase A FE384_17660 ENOG4105D6S protein involved in catabolism of external DNA FE384_17665 ENOG4105DC8 reductase FE384_17675 ENOG4105KBH arsR family transcriptional regulator FE384_17680 ENOG4107R5R arsenical pump membrane protein FE384_17685 ENOG4105K89 arsenate reductase FE384_17695 ENOG4105F2I Transposase FE384_17705 ENOG4105Y4Z Outer Membrane Lipoprotein FE384_17715 ENOG4105KT7 mgtC SapB transporter FE384_17720 ENOG4105XXV Acid-resistance protein FE384_17725 ENOG41060V2 Acid-resistance protein FE384_17730 ENOG4108YK4 Acid-resistance membrane protein FE384_17735 ENOG4106WJ0 Regulates the expression of several genes involved in acid resistance. Required for the expression of gadA and gadBC, among others, regardless of media or growth conditions. Binds directly to the 20 bp GAD box found in the control regions of both loci FE384_17745 ENOG4105C1P efflux transporter, rnd family, mfp subunit FE384_17755 ENOG4105D3F AraC Family Transcriptional Regulator FE384_17760 ENOG4108NKV transcriptional regulator FE384_17765 ENOG4105CVK Glutamate decarboxylase FE384_17770 ENOG4105CA0 peroxidase FE384_17775 ENOG4105E53 ec 3.2.1.28 FE384_17780 ENOG4106S2D Transcriptional regulator FE384_17785 ENOG4105CBN LysR family transcriptional regulator FE384_17790 ENOG4107H3J ribonuclease FE384_17795 ENOG4105CSH Transporter FE384_17800 ENOG41066T0 asmA family FE384_17805 ENOG4105CMB EAL domain-containing protein FE384_17810 ENOG4107SS6 2-dehydro-3-deoxygluconokinase FE384_17815 ENOG4105CS0 peptidase FE384_17825 ENOG4105BZU Histidine kinase FE384_17830 ENOG4105EJG cellulose synthase FE384_17835 ENOG4105K2Z endo-1,4-d-glucanase (EC 3.2.1.4) FE384_17840 ENOG4107EEX Cellulose synthase regulator protein FE384_17845 ENOG4107QZ7 Cellulose synthase catalytic subunit FE384_17855 ENOG410661M cytoplasmic protein FE384_17860 ENOG4105U74 cellulose biosynthesis protein BcsE FE384_17865 ENOG4105WQA Cellulose biosynthesis protein BcsF FE384_17870 ENOG4105D1V cellulose synthase operon protein YhjU FE384_17885 ENOG4105C44 Serine transporter FE384_17890 ENOG4108JQ7 (ABC) transporter FE384_17895 ENOG4105C3U ABC transporter FE384_17900 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component FE384_17905 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component FE384_17915 ENOG4105DEF Extracellular solute-binding protein, family 5 FE384_17930 ENOG4105DIJ Phosphoethanolamine transferase FE384_17935 ENOG4105FCD Major Facilitator FE384_17940 ENOG4105EAX Putative lipase FE384_17945 ENOG4108R3E Dna-3-methyladenine glycosylase i FE384_17950 ENOG4105HNP -acetyltransferase FE384_17955 ENOG4107QY8 reductase FE384_17960 ENOG4108ZG0 Ompa motb domain protein FE384_17970 ENOG4106JH6 (LipO)protein FE384_17975 ENOG4105MVF Transcriptional regulator FE384_17980 ENOG4105VEQ Cold shock protein FE384_17985 ENOG41060TC Hok gef cell toxic protein FE384_18000 ENOG4108HMW glycyl-tRNA synthetase, alpha subunit FE384_18005 ENOG4105RGS lipoprotein ysaB FE384_18010 ENOG4105MEV Acyl-transferase FE384_18015 ENOG4108Z12 YiaAB two helix domain-containing protein FE384_18020 ENOG410688U Inner membrane protein yiaB FE384_18025 ENOG4105CMG Carbohydrate kinase FE384_18035 ENOG4105DFW ABC transporter FE384_18040 ENOG4105C2J ABC transporter FE384_18045 ENOG4107RNG ABC transporter FE384_18050 ENOG4105T16 Transcriptional regulator (AraC family) FE384_18055 ENOG4108UR8 BAX protein FE384_18060 ENOG4107T9C Alpha amylase catalytic region FE384_18065 ENOG4105JKW Valine--pyruvate aminotransferase FE384_18070 ENOG4108XIB electron transport protein ysaA FE384_18075 ENOG4105J4Q Transcriptional regulator FE384_18085 ENOG4108R66 Conserved Protein FE384_18090 ENOG4105XDZ Tripartite ATP-independent periplasmic transporter FE384_18100 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit FE384_18105 ENOG4105CMG Carbohydrate kinase FE384_18110 ENOG4105H6Q decarboxylase FE384_18115 ENOG41064BZ L-xylulose 5-phosphate 3-epimerase FE384_18120 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase FE384_18130 ENOG4105GNX MltA-interacting MipA family protein FE384_18135 ENOG4108Q2M Transcriptional regulator FE384_18140 ENOG4105EFX secretion protein, HlyD family FE384_18145 ENOG4105KK7 inner membrane protein YiaW FE384_18155 ENOG4105C26 Dehydrogenase FE384_18160 ENOG4105C0A alcohol dehydrogenase FE384_18165 ENOG4105EM7 Selenocysteine-specific translation elongation factor FE384_18175 ENOG4108U78 Glutathione S-transferase FE384_18180 ENOG4105CNA YD repeat protein FE384_18185 ENOG4105NUP lyase containing HEAT-repeat FE384_18225 ENOG4105EFX secretion protein, HlyD family FE384_18230 ENOG4105FP6 Protein of unknown function (DUF3302) FE384_18235 ENOG4105CTS PTS system mannitol-specific FE384_18245 ENOG4105E61 Mannitol repressor protein FE384_18255 ENOG4108YYI Protein of unknown function (DUF2810) FE384_18260 ENOG4105DAA L-lactate FE384_18265 ENOG41073TP transcriptional regulator FE384_18275 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) FE384_18280 ENOG4105D7W serine acetyltransferase FE384_18295 ENOG4105VW4 glutaredoxin 3 FE384_18300 ENOG4107YZP Rhodanese domain protein FE384_18305 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) FE384_18310 ENOG41063SB peptidase FE384_18315 ENOG4105PXI polysaccharide deacetylase FE384_18320 ENOG4105K64 Glycosyl transferase, family 2 FE384_18330 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) FE384_18335 ENOG4108SEH involved in lipopolysaccharide biosynthesis FE384_18345 ENOG4105XA0 heptosyltransferase ii FE384_18350 ENOG4105D16 lipopolysaccharide heptosyltransferase i FE384_18365 ENOG4108QD8 lipopolysaccharide core biosynthesis protein FE384_18370 ENOG4108PDR lipopolysaccharide core biosynthesis protein FE384_18380 ENOG4106AH0 Glycosyl Transferase FE384_18385 ENOG4107XU6 Glycosyl transferase (Group 1 FE384_18390 ENOG410650X lipopolysaccharide core region biosynthetic process FE384_18395 ENOG4107543 (lipo)polysaccharide FE384_18400 ENOG4107RJ7 Glycosyl transferase (Group 1 FE384_18405 ENOG4105DKP glycosyl transferase, family 9 FE384_18410 ENOG4105D8A 3-Deoxy-D-manno-octulosonic-acid transferase FE384_18425 ENOG4105W0E 50S ribosomal protein L33 FE384_18440 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase FE384_18465 ENOG4105DSJ YicC domain protein FE384_18470 ENOG4105F5P DNA-damage-inducible protein d FE384_18475 ENOG4105EN6 Membrane FE384_18485 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) FE384_18490 ENOG4105VFG Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) FE384_18495 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) FE384_18500 ENOG4105FE8 tRNA (Guanosine-2'-O-)-methyltransferase FE384_18505 ENOG4105CB5 ATP-dependent DNA helicase recG FE384_18510 ENOG4105D6U Sodium Glutamate Symporter FE384_18515 ENOG4105C2W permease FE384_18520 ENOG4105JV1 AsmA family FE384_18525 ENOG4105CJQ hydrolase, family 31 FE384_18530 ENOG4105CT4 transporter FE384_18545 ENOG4105S8Q sugar efflux transporter FE384_18550 ENOG4108UZ3 Transporter FE384_18555 ENOG4105D01 (LipO)protein FE384_18560 ENOG4105T8A Uncharacterized protein YicS FE384_18570 ENOG4108SAJ Protein of unknown function (DUF1198) FE384_18575 ENOG4105C7N Xanthine uracil vitamin C permease FE384_18585 ENOG4105CXY transporter FE384_18590 ENOG4105CXY transporter FE384_18595 ENOG4105BZU Histidine kinase FE384_18600 ENOG4108KX4 response regulator FE384_18605 ENOG4105M71 acetolactate synthase 1 regulatory subunit FE384_18610 ENOG4105C7K acetolactate synthase FE384_18625 ENOG4105E5M Multidrug resistance protein D FE384_18630 ENOG4105J13 transcriptional regulator FE384_18635 ENOG4105JP4 Inner membrane protein yidG FE384_18640 ENOG4105VG5 Membrane FE384_18645 ENOG4106DRA Inner membrane protein YidI FE384_18650 ENOG4105CBG Sulfatase FE384_18655 ENOG4107RUZ Sss sodium solute transporter superfamily FE384_18660 ENOG4108AHD Transcriptional regulator FE384_18675 ENOG4105FDP GntR family transcriptional regulator FE384_18695 ENOG4105R2A (LipO)protein FE384_18700 ENOG4105D99 atp gtp-binding protein FE384_18705 ENOG4107WAP fad NAD(P)-binding domain FE384_18710 ENOG4105DJB Major Facilitator Superfamily FE384_18720 ENOG4108RTU Aldolase FE384_18725 ENOG4105EI3 2-dehydro-3-deoxygalactonokinase EC 2.7.1.58 FE384_18730 ENOG4105EMF GntR family transcriptional regulator FE384_18735 ENOG410657R replicase EC 2.7 FE384_18740 ENOG410667J hydrolase FE384_18745 ENOG4105VP5 Bacterial protein of unknown function (DUF937) FE384_18750 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) FE384_18760 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) FE384_18810 ENOG4108P6C Tryptophan transporter of low affinity FE384_18825 ENOG4105E8Q phosphopantetheinyl transferase FE384_18830 ENOG4108YYH Nadph-dependent fmn reductase FE384_18835 ENOG4105C7N Xanthine uracil vitamin C permease FE384_18840 ENOG4107UB3 HAD-superfamily hydrolase subfamily IA variant 3 FE384_18845 ENOG4106HGK Inner membrane protein yieI FE384_18850 ENOG4106611 bacteriocin immunity FE384_18855 ENOG4107VKM 6-phosphogluconolactonase FE384_18860 ENOG4105DYC esterase FE384_18865 ENOG4108P68 Outer membrane porin FE384_18870 ENOG4105CS2 ec 3.2.1.21 FE384_18875 ENOG4105C5Y PTS System FE384_18885 ENOG4108UTW Plays a role in the regulation of phosphate uptake FE384_18890 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) FE384_18895 ENOG4105E2Z phosphate ABC transporter (Permease FE384_18900 ENOG4105C8U phosphate abc transporter FE384_18905 ENOG4107QMV Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity) FE384_18910 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) FE384_18950 ENOG4105KY6 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) FE384_18960 ENOG4105GXX Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit I associates with the membrane and may be involved with cation translocation FE384_18975 ENOG4105QTB Flavodoxin FE384_18980 ENOG4108VVK transcriptional Regulator, AsnC FE384_18990 ENOG4105EV2 VWA domain protein interacting with AAA ATPase FE384_19005 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) FE384_19010 ENOG4105C2J ABC transporter FE384_19015 ENOG4105CNN ABC, transporter FE384_19020 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator FE384_19025 ENOG4108RVA ribokinase FE384_19030 ENOG4105ETE Transcriptional regulator (LacI family FE384_19035 ENOG4105C0R drug resistance transporter emrb qaca subfamily FE384_19040 ENOG4107EJG GntR family transcriptional regulator FE384_19080 ENOG4108WFC UPF0438 protein yifE FE384_19085 ENOG4105C0P Mg chelatase subunit ChlI FE384_19105 ENOG4105P3Y Acetolactate synthase 2 regulatory subunit FE384_19110 ENOG4105CM2 brancheD-chain amino acid aminotransferase FE384_19120 ENOG4105C7B Threonine dehydratase FE384_19125 ENOG4105EMY transcriptional regulator FE384_19135 ENOG4105KQ5 peptidylprolyl cis-trans isomerase FE384_19145 ENOG4105C4R Atp-dependent dna helicase FE384_19150 ENOG4105C9X ppx gppa phosphatase FE384_19160 ENOG4105K63 Thioredoxin FE384_19175 ENOG4105ESV Glycosyl transferase, family 4 FE384_19180 ENOG4105SFE lipopolysaccharide biosynthesis protein FE384_19185 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase FE384_19190 ENOG4108IJ1 Dehydrogenase FE384_19195 ENOG4105C1B dTDP-glucose 4-6-dehydratase FE384_19200 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) FE384_19205 ENOG4108WJ1 acetyltransferase FE384_19210 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase FE384_19215 ENOG4105EGZ biosynthesis protein FE384_19235 ENOG4105C85 amino acid FE384_19260 ENOG4105C4X radical SAM domain protein FE384_19265 ENOG4105ENH Sulfatase FE384_19270 ENOG410601J HemY protein FE384_19275 ENOG4105ECF c-methyltransferase FE384_19280 ENOG41076E6 Uroporphyrinogen-III Synthase FE384_19290 ENOG4107T0K Adenylate cyclase FE384_19305 ENOG4105S7Z (LipO)protein FE384_19315 ENOG4105CT0 Protein of unknown function, DUF484 FE384_19325 ENOG4105DFC had-superfamily hydrolase, subfamily ia, variant FE384_19330 ENOG4105C4R Atp-dependent dna helicase FE384_19335 ENOG4108T58 Mg2 transport protein CorA FE384_19340 ENOG4107QUT magnesium and cobalt transport protein CorA FE384_19345 ENOG4105NRM Membrane FE384_19355 ENOG4105FR1 rard protein FE384_19360 ENOG4108VUY thioesterase Superfamily protein FE384_19365 ENOG4105HDD phospholipase FE384_19370 ENOG4105C9U ATP-dependent DNA helicase RecQ FE384_19385 ENOG4108EUD Lysophospholipase FE384_19390 ENOG4105DQF Hydrolase FE384_19395 ENOG4105EMK carboxylate amino acid amine transporter FE384_19400 ENOG4105DZ2 Transcriptional regulator FE384_19405 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) FE384_19410 ENOG4105CDZ Carboxymethylenebutenolidase (EC 3.1.1.45) FE384_19415 ENOG4108I5U Uridine phosphorylase FE384_19420 ENOG4105CGY Dna recombination protein FE384_19430 ENOG4105JC1 sterol-binding domain protein FE384_19440 ENOG4105WKS Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) FE384_19445 ENOG4105X8U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity) FE384_19450 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) FE384_19455 ENOG4105F8V Hydrolase, tatD family FE384_19460 ENOG4105MDZ Transcriptional activator rfaH FE384_19465 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) FE384_19470 ENOG4107QK7 reductase FE384_19475 ENOG4105CHU acetyl-coa acetyltransferase FE384_19490 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein FE384_19495 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) FE384_19500 ENOG4108RR8 protoporphyrinogen oxidase FE384_19535 ENOG4105FNP Molybdopterin-guanine dinucleotide biosynthesis protein b FE384_19540 ENOG4105C6R Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) FE384_19545 ENOG4105PC1 Conserved Protein FE384_19550 ENOG4105E27 serine threonine protein kinase FE384_19555 ENOG4108Z33 Thiol disulfide Interchange Protein FE384_19565 ENOG4106HNH Acyl-transferase FE384_19575 ENOG4105C2M dna polymerase I FE384_19590 ENOG4105D4P Coproporphyrinogen iii oxidase FE384_19595 ENOG4106FIY FE384_19600 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family FE384_19605 ENOG4105CUX Signal transduction histidine kinase FE384_19610 ENOG4105C5F glutamine synthetase FE384_19620 ENOG4108K85 Transcriptional regulator FE384_19625 ENOG4108KHF Resistance protein FE384_19630 ENOG4105R9B Major Facilitator FE384_19635 ENOG4108KUC Outer membrane channel protein that allows an efficient diffusion of low-molecular-weight solutes such as small sugars and tetraglycine. However, the specific substrate recognized by the OmpL channel is FE384_19640 ENOG4105CT4 transporter FE384_19645 ENOG4105CT4 transporter FE384_19650 ENOG4105CJQ hydrolase, family 31 FE384_19655 ENOG4107WI4 Aldose-1-epimerase FE384_19660 ENOG4107QKS N-acylglucosamine 2-epimerase FE384_19665 ENOG4105D2M Aldolase FE384_19670 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase FE384_19675 ENOG4108MGF sugar kinase FE384_19680 ENOG4105E98 transcriptional regulator DeoR family FE384_19685 ENOG4105EJU HAD-superfamily hydrolase subfamily IA variant 3 FE384_19700 ENOG4105SUU thioesterase domain FE384_19705 ENOG4106UEE Transcriptional regulator FE384_19710 ENOG41068KX affects formate dehydrogenase-N FE384_19720 ENOG4108MG3 formate dehydrogenase FE384_19725 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein FE384_19740 ENOG4108V87 frv operon regulatory protein FE384_19745 ENOG4106C3V frv operon regulatory protein FE384_19750 ENOG4105CN9 Peptidase m42 family protein FE384_19755 ENOG4105DM4 PTS System FE384_19760 ENOG41064BA PTS system, fructose-specific, IIA component FE384_19800 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) FE384_19810 ENOG4108RPX mosc domain containing protein FE384_19815 ENOG4105E0F Histidine kinase FE384_19820 ENOG4105E3W Two component transcriptional regulator (Winged helix family FE384_19825 ENOG4105FMW periplasmic FE384_19840 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein FE384_19855 ENOG4105EBK exported protein FE384_19860 ENOG4108VTS Membrane FE384_19865 ENOG41065TG regulatoR FE384_19875 ENOG4105DP0 ferredoxin-NADP reductase FE384_19880 ENOG4105CBT Fructose-1,6-bisphosphatase FE384_19890 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) FE384_19905 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase FE384_19910 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) FE384_19920 ENOG41063M6 Cell Division Protein FE384_19925 ENOG4105ETE Transcriptional regulator (LacI family FE384_19930 ENOG4105C25 Primosomal protein n' FE384_19940 ENOG4107S01 Repressor protein MetJ FE384_19950 ENOG4105C28 cystathionine FE384_19955 ENOG4105CFH Aspartokinase FE384_19960 ENOG4105SYT Methylenetetrahydrofolate reductase FE384_19965 ENOG4105C1X Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity (By similarity) FE384_19970 ENOG4108Q5Y Membrane FE384_19975 ENOG4108XC3 NADH ubiquinone oxidoreductase FE384_19980 ENOG4105DCT glycerol dehydrogenase FE384_19985 ENOG4107T9Z Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) FE384_19990 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) FE384_19995 ENOG4105DM4 PTS System FE384_20000 ENOG4108YRF PTS System FE384_20005 ENOG4105C6N Formate acetyltransferase FE384_20010 ENOG4108AHH pyruvate formate lyase II activase FE384_20015 ENOG4108XCZ PTS System FE384_20020 ENOG4106R3P AraC family transcriptional regulator FE384_20025 ENOG4105DIJ Phosphoethanolamine transferase FE384_20040 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase FE384_20045 ENOG4105CAS nag kinase FE384_20055 ENOG4105C5Q Transcriptional regulator FE384_20065 ENOG4105EJ2 Transcriptional regulator FE384_20070 ENOG4108Y73 Membrane FE384_20080 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) FE384_20115 ENOG4105D4A Cell wall formation (By similarity) FE384_20120 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase FE384_20155 ENOG4105PM1 preprotein translocase subunit SecE FE384_20160 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) FE384_20195 ENOG410645W Thiamin biosynthesis protein ThiH FE384_20200 ENOG4105D41 biosynthesis protein thiH FE384_20210 ENOG4105WHD thiamine biosynthesis protein ThiS FE384_20215 ENOG4105D06 uba thif-type nad fad binding protein FE384_20250 ENOG4105R2J Conserved Protein FE384_20255 ENOG4105K70 DNA-binding protein FE384_20260 ENOG4108T8B Protein of unknown function (DUF1481) FE384_20265 ENOG4105JBU Binds zinc. Could be an important component of the zinc- balancing mechanism FE384_20270 ENOG4105BZU Histidine kinase FE384_20275 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family FE384_20280 ENOG4105C12 Phosphoribosylglycinamide synthetase FE384_20310 ENOG41062WK cellular response to acidity FE384_20315 ENOG4105K5X acetyltransferase FE384_20325 ENOG4107QP3 malate synthase g FE384_20330 ENOG4108I9X Isocitrate lyase FE384_20345 ENOG41069M3 Transcriptional regulator FE384_20350 ENOG4105C3R Methionine synthase FE384_20355 ENOG4105EAM Na Pi-cotransporter FE384_20365 ENOG4105FE9 pseudouridine synthase FE384_20370 ENOG4108ZR5 Conserved Protein FE384_20375 ENOG4105CFH Aspartokinase FE384_20390 ENOG4108MDC (LipO)protein FE384_20395 ENOG4108Q9C Periplasmic Protein FE384_20400 ENOG4105E3R (LipO)protein FE384_20415 ENOG4107QNK )-transporter FE384_20420 ENOG4105EG2 ABC transporter, permease FE384_20425 ENOG4105D56 permease protein FE384_20430 ENOG4107FKK extracellular solute-binding protein family 1 FE384_20435 ENOG4108IJ9 (ABC) transporter FE384_20445 ENOG4107W52 maltose operon periplasmic protein FE384_20470 ENOG41080IJ Diacylglycerol kinase FE384_20480 ENOG4107R73 Mate efflux family protein FE384_20485 ENOG4105VDW Csbd family FE384_20490 ENOG4105MYN Zinc uptake regulation protein FE384_20505 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) FE384_20510 ENOG4105P4Z Phage shock protein G FE384_20515 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein FE384_20520 ENOG4105CDU Replicative dna helicase FE384_20525 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) FE384_20530 ENOG4105CGF Aromatic amino acid aminotransferase FE384_20540 ENOG4105F0S class B acid phosphatase FE384_20545 ENOG4108YXI Secondary thiamine-phosphate synthase enzyme FE384_20550 ENOG4105MSB protein, conserved in bacteria FE384_20555 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) FE384_20560 ENOG4108UUM single-stranded DNA-binding protein FE384_20565 ENOG4105PMV Membrane FE384_20570 ENOG4108M8H domain protein FE384_20575 ENOG4108W3Q Transcriptional regulator FE384_20580 ENOG4108Z4X TRANSCRIPTIONal FE384_20585 ENOG4105C7N Xanthine uracil vitamin C permease FE384_20590 ENOG4105EEQ Na H antiporter FE384_20605 ENOG41062QD Membrane FE384_20610 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) FE384_20620 ENOG4105JJ8 Cytochrome c nitrite reductase, pentaheme subunit FE384_20625 ENOG4105D3S 4Fe-4S Ferredoxin, iron-sulfur binding domain protein FE384_20630 ENOG4105DVI reductase, NrfD FE384_20635 ENOG4108QKW cytochrome c-type biogenesis protein FE384_20645 ENOG4108W0S formate-dependent nitrite reductase complex FE384_20650 ENOG4105CK2 sodium dicarboxylate symporter FE384_20655 ENOG41082ND Uncharacterized protein yjcO FE384_20665 ENOG4105ETP RND efflux system, outer membrane lipoprotein FE384_20670 ENOG4108MI0 Resistance protein FE384_20675 ENOG4105J12 Multidrug resistance protein mdtN FE384_20680 ENOG4106833 FE384_20685 ENOG4105EUZ Beta-lactamase domain protein FE384_20690 ENOG4107TFG D-allose kinase FE384_20695 ENOG4105UP7 3-epimerase FE384_20700 ENOG4105CNN ABC, transporter FE384_20705 ENOG4105C2J ABC transporter FE384_20710 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator FE384_20715 ENOG4105NYY transcriptional regulator, RpiR FE384_20720 ENOG4108YZG isomerase FE384_20725 ENOG4106ZVZ Escherichia coli IMT2125 genomic chromosome, IMT2125 FE384_20730 ENOG4107SA6 carbon-phosphorus lyase complex accessory protein FE384_20735 ENOG410849A acetyltransferase, (GNAT) family FE384_20740 ENOG4105MFQ Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP) (By similarity) FE384_20745 ENOG4105FD8 phosphonate metabolism protein PhnM FE384_20750 ENOG4105HRV phosphonate c-p lyase system protein phnl FE384_20755 ENOG4105ENV phosphonate C-P lyase system protein PhnK FE384_20760 ENOG4105FT8 Phosphonate metabolism FE384_20765 ENOG4105EKV Phosphonate metabolism protein FE384_20770 ENOG4105KZ6 phosphonate C-P lyase system protein PhnH FE384_20780 ENOG4107RJJ Transcriptional regulator FE384_20790 ENOG4105EHI Phosphonate ABC transporter, periplasmic FE384_20795 ENOG4105D5T phosphonate abc transporter FE384_20800 ENOG4108SQ4 Glyoxalase Bleomycin resistance protein (Dioxygenase FE384_20805 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA FE384_20810 ENOG4108F5E vimentin FE384_20815 ENOG4108YIV FE384_20820 ENOG4105CSH Transporter FE384_20830 ENOG4105ECM Sensor protein basS pmrB FE384_20835 ENOG4105XJC Two component transcriptional regulator (Winged helix family FE384_20840 ENOG4105DIJ Phosphoethanolamine transferase FE384_20845 ENOG4105D5Q Arginine ornithine antiporter FE384_20850 ENOG4106ZGR Transcriptional regulator FE384_20855 ENOG4105CXN decarboxylase FE384_20860 ENOG4108K2B transcriptional regulator FE384_20865 ENOG4105F8D glycoside hydrolase family 4 FE384_20870 ENOG4105CT4 transporter FE384_20875 ENOG4108R5S membrane FE384_20880 ENOG4107GFK fumarate FE384_20885 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter FE384_20890 ENOG4108MRH transcriptional regulatory protein FE384_20895 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism FE384_20900 ENOG4105VR1 Pfam:DUF1271 FE384_20905 ENOG410830R acetyltransferase FE384_20920 ENOG4105CRK lysyL-tRNA synthetase FE384_20925 ENOG4105DUX Transporter FE384_20935 ENOG4105D5Q Arginine ornithine antiporter FE384_20940 ENOG4108M3R transcriptional activator CadC FE384_20950 ENOG4108SIC Transcriptional regulator FE384_20955 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) FE384_20965 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter FE384_20970 ENOG4108IJ0 Aspartate ammonia-lyase FE384_20975 ENOG4108YH1 overproduction of this protein in Escherichia coli inhibits the F plasmid-mediated exclusion of bacteriophage T7 FE384_20980 ENOG4105DVH amino acid FE384_20995 ENOG4108ZVF (LipO)protein FE384_21000 ENOG4105MTB Uncharacterized protein YjeJ FE384_21005 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein FE384_21015 ENOG4106HKS Entericidin EcnA/B family FE384_21020 ENOG4106BSU Entericidin B FE384_21025 ENOG4105KPY Small multidrug resistance protein FE384_21030 ENOG4105QNF Outer membrane lipoprotein FE384_21035 ENOG41066YJ Beta-lactamase FE384_21050 ENOG4105E33 succinate dehydrogenase FE384_21055 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) FE384_21065 ENOG4107SC7 Inner membrane transporter yjeM FE384_21070 ENOG4106V5W FE384_21075 ENOG4106CG8 Inner membrane protein YjeO FE384_21080 ENOG4105EGS Mechanosensitive ion channel FE384_21120 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) FE384_21125 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) FE384_21130 ENOG4105K8N protein family UPF0079, ATPase FE384_21135 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase FE384_21150 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) FE384_21155 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) FE384_21160 ENOG4107QJR hflk protein FE384_21165 ENOG4105EPW hflc protein FE384_21185 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) FE384_21190 ENOG4105C2N RNA methyltransferase TrmH family group 3 FE384_21195 ENOG4105FUX Conserved Protein FE384_21200 ENOG4108P9J Phage shock protein A FE384_21205 ENOG4107VNS Protein of unknown function (DUF2491) FE384_21210 ENOG4105Z6B inner membrane protein yjfl FE384_21215 ENOG4108KXT Conserved Protein FE384_21220 ENOG4106032 Glutathionylspermidine synthase FE384_21225 ENOG4105CSU acyl-Coa dehydrogenase FE384_21230 ENOG4105S17 UPF0379 protein yjfN FE384_21235 ENOG4105WSB biofilm stress and motility protein A FE384_21240 ENOG4108MXZ Esterase FE384_21255 ENOG4105CZC PTS system ascorbate-specific transporter subunit IIC FE384_21260 ENOG410907W The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in ascorbate transport FE384_21265 ENOG4106ETB IIa component FE384_21285 ENOG4105KIT UPF0379 protein yjfY FE384_21300 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) FE384_21320 ENOG4105FHY Opacity-associated protein A FE384_21325 ENOG4108V1T peptidylprolyl cis-trans isomerase FE384_21330 ENOG4105C85 amino acid FE384_21340 ENOG4105DXC membrane FE384_21345 ENOG4105ECR NmrA family FE384_21350 ENOG4105KVH Transcriptional regulator FE384_21355 ENOG4107RNS bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase 3'-nucleotidase periplasmic FE384_21360 ENOG4108RNI 3'(2')5'-bisphosphate nucleotidase FE384_21370 ENOG4108UUE Transcriptional regulator FE384_21375 ENOG41061GZ Protein of unknown function (DUF1107) FE384_21380 ENOG4105C37 (CBS) domain FE384_21390 ENOG4105CFU surface antigen FE384_21395 ENOG4105MA0 exported protein FE384_21400 ENOG4108ZHD aig2 family FE384_21405 ENOG41087RY SpoVT_AbrB FE384_21410 ENOG4105MZG transcriptional modulator of maze toxin, mazf FE384_21415 ENOG4105F0N pyrophosphate phospho-hydrolase FE384_21420 ENOG4107R5U Periplasmic binding protein LacI transcriptional regulator FE384_21425 ENOG4105C2J ABC transporter FE384_21430 ENOG4107R9N ABC transporter FE384_21435 ENOG41062B0 ABC transporter, permease FE384_21445 ENOG4105DFU Cell wall formation (By similarity) FE384_21455 ENOG4105CMS peptidase U62, modulator of DNA gyrase FE384_21465 ENOG4108RDD Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine (By similarity) FE384_21470 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase FE384_21475 ENOG4105CG3 alpha amylase, catalytic region FE384_21480 ENOG4105C5Y PTS System FE384_21485 ENOG4105D4X repressor FE384_21495 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic FE384_21500 ENOG4105KME endoribonuclease L-psp FE384_21515 ENOG41077AM PyrBI operon attenuator FE384_21520 ENOG4108UQ8 endoribonuclease L-psp FE384_21525 ENOG4105F6U Short-chain dehydrogenase reductase Sdr FE384_21530 ENOG4108XFH Transcriptional regulator FE384_21535 ENOG4105XEP YhcH YjgK YiaL family protein FE384_21545 ENOG4105DBV ornithine carbamoyltransferase FE384_21550 ENOG4105KQT Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome (By similarity) FE384_21555 ENOG4108MJ3 acetyltransferase FE384_21560 ENOG4108M3P Membrane FE384_21565 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) FE384_21570 ENOG4105MYG DNA polymerase iii, chi subunit FE384_21580 ENOG4108M8S permease YjgP YjgQ family protein FE384_21585 ENOG4108K5H permease YjgP YjgQ family protein FE384_21590 ENOG4105D7A ATP-binding protein FE384_21595 ENOG4105K2J Transcriptional regulator FE384_21600 ENOG4105C6Z Gluconate FE384_21605 ENOG4105CHR reductase FE384_21610 ENOG4105CPQ Dehydrogenase FE384_21615 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family FE384_21620 ENOG4105DQ4 alcohol dehydrogenase FE384_21655 ENOG4105VNT transposase (IS4 family) protein FE384_21665 ENOG4107RJ5 oxidoreductase FE384_21690 ENOG4105F9F transposase FE384_21710 ENOG4105E0A ABC, transporter FE384_21715 ENOG4108IHU transport system permease protein FE384_21720 ENOG4105DQ5 transport system permease protein FE384_21725 ENOG4108HUF Transporter FE384_21730 ENOG4105GAV receptor FE384_21735 ENOG4108S3W Anti-feci sigma factor, fecr FE384_21740 ENOG4108SF5 RNA Polymerase FE384_21750 ENOG4105DKT Transcriptional regulator FE384_21755 ENOG4105C6Z Gluconate FE384_21760 ENOG4105C01 Dihydroxy-acid dehydratase FE384_21765 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) FE384_21770 ENOG4106P37 HTH-type transcriptional regulator YjhI FE384_21775 ENOG4108PQ7 sgc region transcriptional regulator FE384_21780 ENOG4108RK0 3-epimerase FE384_21785 ENOG4108XBJ The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane (By similarity) FE384_21790 ENOG4106P19 photosystem i assembly btpa FE384_21795 ENOG4105DT3 PTS system, galactitol-specific IIc component FE384_21800 ENOG4105K18 The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane (By similarity) FE384_21805 ENOG4105CN9 Peptidase m42 family protein FE384_21815 ENOG4105DTA methyltransferase FE384_21820 ENOG41080VW acetyltransferase FE384_21845 ENOG4108MX5 Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses (By similarity) FE384_21850 ENOG41069FU Outer membrane channel protein allowing the entry of N- acetylneuraminic acid (Neu5Ac, the most abundant sialic acid on host cell surfaces) into the bacteria FE384_21855 ENOG4108W9T type 1 fimbriae regulatory protein FE384_21860 ENOG4105E71 FimE is one of the 2 regulatory proteins which control the phase variation of type 1 fimbriae in E.coli. These proteins mediate the periodic inversion of a 300bp DNA segment that harbors the promoter for the fimbrial structural gene, fimA. FimE switches fimA off FE384_21865 ENOG4108RQP Major type 1 subunit fimbrin FE384_21870 ENOG4108S54 Fimbrial protein FE384_21875 ENOG4108NAE Fimbrial chaperone protein FE384_21880 ENOG4105CW0 outer membrane usher protein FE384_21885 ENOG4108SQA Fimbrial FE384_21890 ENOG4108T65 Fimbrial FE384_21895 ENOG410643X FIMH SUBUNIT MANNOSE-sensitive type 1 fimbrial adhesin FE384_21900 ENOG4107EFN gluconate transport system permease 3 FE384_21910 ENOG4105DEI Mannitol dehydrogenase FE384_21915 ENOG4105C6F GntR Family Transcriptional Regulator FE384_21935 ENOG4107YNJ LysR family Transcriptional regulator FE384_21940 ENOG4105DYB Isoaspartyl dipeptidase FE384_21945 ENOG4108P2H Inner membrane protein YjiG FE384_21950 ENOG41074DU domain protein FE384_21960 ENOG4105CBP Major Facilitator FE384_21965 ENOG4108ZK4 sdia-regulated domain-containing protein FE384_21975 ENOG4105CIZ coA-substrate-specific enzyme activase FE384_21980 ENOG4105DCU 2-hydroxyglutaryl-CoA dehydratase FE384_21985 ENOG4106BRA Membrane FE384_21990 ENOG41083G8 Multidrug resistance protein MdtM FE384_22000 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family FE384_22005 ENOG4106DIZ Domain of unknown function (DUF1127) FE384_22010 ENOG4108YUH FE384_22020 ENOG4107SQC 5-methylcytosine-specific restriction enzyme subunit McrC FE384_22025 ENOG4105FBQ ATPase associated with various cellular activities aaa_5 FE384_22035 ENOG4107XZC Restriction modification system DNA (Specificity FE384_22040 ENOG4105CVR type I restriction-modification system FE384_22045 ENOG4107SCJ type I restriction enzyme EcoKI subunit R FE384_22050 ENOG4106H3A restriction FE384_22055 ENOG4105CKI cobalamin synthesis protein FE384_22060 ENOG4105VCD cytoplasmic protein FE384_22065 ENOG4105D22 carbon starvation protein FE384_22070 ENOG4105C8Q Methyl-accepting chemotaxis FE384_22075 ENOG4108I5G Major Facilitator superfamily FE384_22080 ENOG410617M Transcriptional regulator FE384_22085 ENOG4105CPQ Dehydrogenase FE384_22095 ENOG4105RI1 glycoprotein receptor FE384_22100 ENOG4106CVF DNA replication protein FE384_22115 ENOG4105DWK Membrane FE384_22120 ENOG4108N8T regulatoR FE384_22125 ENOG4108T94 DNA-binding transcriptional activator BglJ FE384_22130 ENOG4108819 ferric iron reductase FE384_22135 ENOG4105YBH Protein of unknown function (DUF1435) FE384_22160 ENOG4108WPU DNA polymerase III subunit psi FE384_22165 ENOG4105KEG ribosomal-protein-alanine acetyltransferase FE384_22170 ENOG4105PAD Hydrolase FE384_22180 ENOG4105K3G Periplasmic Protein FE384_22190 ENOG4108NRW Phospholipase, patatin family FE384_22195 ENOG4105EYA deoxyribonuclease FE384_22200 ENOG41076CZ activating enzyme FE384_22205 ENOG4105G0K glycine radical enzyme YjjI family FE384_22230 ENOG4105EUP HipA domain protein FE384_22240 ENOG4107RMF Catalyzes both the ATP-dependent activation of exogenously supplied lipoate to lipoyl-AMP and the transfer of the activated lipoyl onto the lipoyl domains of lipoate-dependent enzymes (By similarity) FE384_22245 ENOG4105EAC phosphoserine phosphatase FE384_22250 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) FE384_22255 ENOG4107VZS Nicotinamide-nucleotide adenylyltransferase FE384_22260 ENOG4105C5H ABC transporter FE384_22265 ENOG4107SC1 transglycosylase FE384_22285 ENOG4105UEI Transcriptional Regulator AraC Family FE384_22290 ENOG4108RH0 Crea protein FE384_22295 ENOG4105E3W Two component transcriptional regulator (Winged helix family FE384_22300 ENOG4105EB3 Histidine kinase FE384_22305 ENOG4105CT7 inner membrane cred family protein FE384_22310 ENOG41065U4 response regulator FE384_22315 ENOG410759A FE384_22320 ENOG4106FVC RNA methyltransferase