locus-tag	class	description
HVW76_00010	COG0592	DNA-directed DNA polymerase activity
HVW76_00020	COG0187	DNA topoisomerase II activity
HVW76_00025	COG3753	Protein conserved in bacteria
HVW76_00030	COG0561	phosphatase activity
HVW76_00045	COG0823	Involved in the tonB-independent uptake of proteins
HVW76_00050	COG5645	(Lipo)protein
HVW76_00070	COG2188	Transcriptional regulator
HVW76_00085	COG2207	Transcriptional regulator
HVW76_00090	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HVW76_00105	COG2149	membrane
HVW76_00115	COG0641	radical SAM
HVW76_00120	COG2814	Major facilitator Superfamily
HVW76_00135	COG0028	Belongs to the TPP enzyme family
HVW76_00140	COG0440	acetolactate synthase activity
HVW76_00155	COG2197	response regulator
HVW76_00160	COG3851	Histidine kinase
HVW76_00165	COG2271	Major facilitator Superfamily
HVW76_00170	COG2271	Major facilitator Superfamily
HVW76_00185	COG1447	Phosphotransferase system cellobiose-specific component IIA
HVW76_00190	COG2723	6-phospho-beta-galactosidase activity
HVW76_00195	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HVW76_00205	COG1609	Transcriptional regulator
HVW76_00220	COG2252	PERMEase
HVW76_00245	COG4932	domain protein
HVW76_00245	COG2373	Large extracellular alpha-helical protein
HVW76_00245	COG1388	LysM domain
HVW76_00275	COG0457	Tetratricopeptide repeat
HVW76_00285	COG1464	Belongs to the NlpA lipoprotein family
HVW76_00290	COG0697	spore germination
HVW76_00295	COG2814	Major facilitator Superfamily
HVW76_00310	COG2211	Major facilitator Superfamily
HVW76_00315	COG1501	Belongs to the glycosyl hydrolase 31 family
HVW76_00320	COG2982	Protein involved in outer membrane biogenesis
HVW76_00325	COG2233	PERMEase
HVW76_00330	COG0786	glutamate:sodium symporter activity
HVW76_00335	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HVW76_00340	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HVW76_00345	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HVW76_00355	COG0194	GDP metabolic process
HVW76_00365	COG2860	membrane
HVW76_00370	COG3645	SOS response
HVW76_00375	COG1561	YicC-like family, N-terminal region
HVW76_00400	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HVW76_00430	COG1519	Transferase
HVW76_00435	COG0859	PFAM glycosyl transferase family 9
HVW76_00440	COG0438	transferase activity, transferring glycosyl groups
HVW76_00445	COG0515	serine threonine protein kinase
HVW76_00460	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HVW76_00465	COG1442	glycosyl transferase family 8
HVW76_00475	COG3307	-O-antigen
HVW76_00480	COG0859	PFAM glycosyl transferase family 9
HVW76_00485	COG0859	PFAM glycosyl transferase family 9
HVW76_00495	COG0156	8-amino-7-oxononanoate synthase activity
HVW76_00505	COG1216	Glycosyl transferase, family 2
HVW76_00510	COG2861	carbohydrate metabolic process
HVW76_00515	COG4942	peptidase
HVW76_00525	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HVW76_00530	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HVW76_00545	COG1045	serine acetyltransferase
HVW76_00550	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HVW76_00560	COG2186	Transcriptional regulator
HVW76_00565	COG1620	l-lactate permease
HVW76_00590	COG3722	fumarate hydratase activity
HVW76_00600	COG2213	PTS system mannitol-specific
HVW76_00600	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HVW76_00610	COG1566	PFAM secretion protein HlyD family protein
HVW76_00615	COG0625	glutathione transferase activity
HVW76_00625	COG3276	selenocysteine insertion sequence binding
HVW76_00630	COG1454	alcohol dehydrogenase
HVW76_00640	COG1012	belongs to the aldehyde dehydrogenase family
HVW76_00655	COG1566	PFAM secretion protein HlyD family protein
HVW76_00660	COG0583	DNA-binding transcription factor activity
HVW76_00665	COG3713	MltA-interacting MipA family protein
HVW76_00675	COG2211	Major facilitator Superfamily
HVW76_00690	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HVW76_00695	COG3977	Valine--pyruvate aminotransferase
HVW76_00700	COG0366	Alpha amylase catalytic
HVW76_00705	COG2992	FlgJ-related protein
HVW76_00710	COG2207	Transcriptional regulator
HVW76_00710	COG1609	Transcriptional regulator
HVW76_00715	COG4214	carbohydrate transport
HVW76_00725	COG4213	ABC transporter substrate-binding protein
HVW76_00735	COG1070	Carbohydrate kinase
HVW76_00740	COG4682	membrane
HVW76_00745	COG4682	membrane
HVW76_00750	COG3274	enterobacterial common antigen metabolic process
HVW76_00775	COG1278	Cold shock
HVW76_00780	COG2944	sequence-specific DNA binding
HVW76_00795	COG2885	chlorophyll binding
HVW76_00800	COG0243	molybdopterin cofactor binding
HVW76_00805	COG0456	acetyltransferase
HVW76_00810	COG2818	Glycosylase
HVW76_00815	COG5571	outer membrane autotransporter
HVW76_00820	COG2223	nitrite transmembrane transporter activity
HVW76_00825	COG3539	Fimbrial protein
HVW76_00830	COG3121	Chaperone
HVW76_00840	COG3539	Fimbrial protein
HVW76_00845	COG3539	Fimbrial protein
HVW76_00850	COG2194	sulfuric ester hydrolase activity
HVW76_00860	COG0747	negative chemotaxis
HVW76_00865	COG0601	transmembrane transport
HVW76_00870	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HVW76_00875	COG0444	Belongs to the ABC transporter superfamily
HVW76_00880	COG4608	Belongs to the ABC transporter superfamily
HVW76_00885	COG0814	amino acid
HVW76_00905	COG2194	sulfuric ester hydrolase activity
HVW76_00930	COG1215	transferase activity, transferring glycosyl groups
HVW76_00935	COG1215	transferase activity, transferring glycosyl groups
HVW76_00940	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
HVW76_00945	COG0457	Tetratricopeptide repeat
HVW76_00945	COG3118	belongs to the thioredoxin family
HVW76_00950	COG2200	EAL domain
HVW76_00950	COG2199	diguanylate cyclase activity
HVW76_00960	COG0612	Peptidase, M16
HVW76_00970	COG2200	EAL domain
HVW76_00975	COG2982	Protein involved in outer membrane biogenesis
HVW76_00980	COG0477	Major facilitator Superfamily
HVW76_00985	COG1295	ribonuclease BN
HVW76_00990	COG0583	DNA-binding transcription factor activity
HVW76_00995	COG2197	response regulator
HVW76_01005	COG1858	cytochrome C peroxidase
HVW76_01010	COG0076	glutamate decarboxylase activity
HVW76_01015	COG2207	Transcriptional regulator
HVW76_01020	COG2207	Transcriptional regulator
HVW76_01025	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HVW76_01030	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HVW76_01040	COG2771	luxR family
HVW76_01045	COG3247	response to pH
HVW76_01060	COG1285	pathogenesis
HVW76_01070	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HVW76_01080	COG3721	Heme iron utilization protein
HVW76_01090	COG4558	Periplasmic binding protein
HVW76_01095	COG4771	TonB-dependent receptor
HVW76_01100	COG3720	iron ion transport
HVW76_01105	COG2197	response regulator
HVW76_01110	COG3065	identical protein binding
HVW76_01120	COG1393	Belongs to the ArsC family
HVW76_01130	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HVW76_01135	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
HVW76_01140	COG0339	signal peptide processing
HVW76_01150	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HVW76_01155	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HVW76_01160	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HVW76_01165	COG0371	Dehydrogenase
HVW76_01175	COG0246	Mannitol dehydrogenase
HVW76_01180	COG1349	DNA-binding transcription factor activity
HVW76_01190	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HVW76_01190	COG2213	PTS system mannitol-specific
HVW76_01200	COG3104	oligopeptide transport
HVW76_01205	COG0589	response to stress
HVW76_01215	COG0306	phosphate transporter
HVW76_01220	COG2081	HI0933 family
HVW76_01240	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HVW76_01245	COG1129	ABC transporter
HVW76_01245	COG0842	Transport permease protein
HVW76_01250	COG0842	Transport permease protein
HVW76_01280	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HVW76_01285	COG0601	transmembrane transport
HVW76_01290	COG0747	negative chemotaxis
HVW76_01295	COG2091	lysine biosynthetic process via aminoadipic acid
HVW76_01300	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HVW76_01305	COG1028	Short-chain dehydrogenase reductase Sdr
HVW76_01315	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HVW76_01340	COG1216	Glycosyl transferase, family 2
HVW76_01360	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HVW76_01370	COG0204	Acyl-transferase
HVW76_01390	COG0628	permease
HVW76_01405	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
HVW76_01420	COG3714	YhhN family
HVW76_01430	COG3776	membrane
HVW76_01435	COG0742	ribosomal rna small subunit methyltransferase
HVW76_01440	COG0552	protein localization to endoplasmic reticulum
HVW76_01445	COG2884	Cell division ATP-binding protein ftsE
HVW76_01450	COG2177	Part of the ABC transporter FtsEX involved in
HVW76_01455	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HVW76_01460	COG0683	leucine binding
HVW76_01465	COG0456	acetyltransferase
HVW76_01470	COG0683	leucine binding
HVW76_01475	COG0559	Belongs to the binding-protein-dependent transport system permease family
HVW76_01480	COG4177	L-phenylalanine transmembrane transporter activity
HVW76_01485	COG0411	ABC transporter
HVW76_01490	COG0410	ABC transporter
HVW76_01500	COG1653	transport
HVW76_01505	COG1175	transmembrane transport
HVW76_01520	COG0584	glycerophosphoryl diester phosphodiesterase
HVW76_01530	COG0405	Gamma-glutamyltransferase
HVW76_01545	COG1247	-acetyltransferase
HVW76_01550	COG0673	inositol 2-dehydrogenase activity
HVW76_01555	COG1741	Belongs to the pirin family
HVW76_01560	COG1609	Transcriptional regulator
HVW76_01565	COG3265	gluconokinase activity
HVW76_01570	COG2610	gluconate transmembrane transporter activity
HVW76_01585	COG2095	MarC family integral membrane protein
HVW76_01590	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HVW76_01595	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HVW76_01615	COG0058	SHG alpha-glucan phosphorylase activity
HVW76_01620	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HVW76_01635	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HVW76_01650	COG1349	DNA-binding transcription factor activity
HVW76_01655	COG4650	regulator
HVW76_01660	COG1690	Belongs to the RtcB family
HVW76_01685	COG0058	SHG alpha-glucan phosphorylase activity
HVW76_01690	COG1640	4-alpha-glucanotransferase
HVW76_01695	COG2610	gluconate transmembrane transporter activity
HVW76_01705	COG1040	competence protein
HVW76_01715	COG5464	transposase or invertase
HVW76_01725	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
HVW76_01730	COG1918	ferrous iron import across plasma membrane
HVW76_01735	COG2183	response to ionizing radiation
HVW76_01740	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HVW76_01745	COG0745	RESPONSE REGULATOR receiver
HVW76_01750	COG2205	protein histidine kinase activity
HVW76_01760	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
HVW76_01770	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HVW76_01775	COG1011	Hydrolase
HVW76_01785	COG0494	nUDIX hydrolase
HVW76_01790	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
HVW76_01795	COG4972	Pilus assembly protein
HVW76_01800	COG3166	PFAM Fimbrial assembly family protein
HVW76_01815	COG4796	Type ii and iii secretion system protein
HVW76_01830	COG3266	domain, Protein
HVW76_01835	COG0338	D12 class N6 adenine-specific DNA methyltransferase
HVW76_01840	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HVW76_01845	COG0546	phosphoglycolate phosphatase activity
HVW76_01850	COG0180	Tryptophanyl-tRNA synthetase
HVW76_01855	COG2188	Transcriptional regulator
HVW76_01865	COG3457	Alanine racemase
HVW76_01870	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
HVW76_01875	COG1735	metal-dependent hydrolase with the TIM-barrel fold
HVW76_01890	COG0626	cystathionine gamma-synthase activity
HVW76_01905	COG2116	formate transmembrane transporter activity
HVW76_01910	COG2146	nitrite reductase [NAD(P)H] activity
HVW76_01915	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HVW76_01925	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HVW76_01935	COG2184	nucleotidyltransferase activity
HVW76_01940	COG0512	Glutamine amidotransferase of anthranilate synthase
HVW76_01945	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HVW76_01950	COG1289	transmembrane transporter activity
HVW76_01955	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HVW76_01960	COG1765	OsmC-like protein
HVW76_01965	COG3954	Phosphoribulokinase
HVW76_01975	COG0429	hydrolase of the alpha beta-hydrolase fold
HVW76_01980	COG0488	(ABC) transporter
HVW76_01995	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
HVW76_02000	COG1047	Peptidyl-prolyl cis-trans
HVW76_02010	COG0545	Peptidyl-prolyl cis-trans isomerase
HVW76_02015	COG2964	Protein conserved in bacteria
HVW76_02085	COG0089	rRNA binding
HVW76_02175	COG0201	protein transport
HVW76_02215	COG0789	Transcriptional regulator
HVW76_02220	COG3036	rescue of stalled ribosome
HVW76_02230	COG0569	domain protein
HVW76_02250	COG0758	DNA mediated transformation
HVW76_02260	COG0551	DNA topoisomerase type I activity
HVW76_02265	COG0009	L-threonylcarbamoyladenylate synthase
HVW76_02280	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HVW76_02320	COG1126	abc transporter atp-binding protein
HVW76_02325	COG0765	amino acid transport
HVW76_02330	COG4597	amino acid ABC transporter
HVW76_02335	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HVW76_02345	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HVW76_02350	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HVW76_02355	COG1309	transcriptional regulator
HVW76_02365	COG2189	Belongs to the N(4) N(6)-methyltransferase family
HVW76_02375	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HVW76_02385	COG4145	pantothenate transmembrane transporter activity
HVW76_02390	COG3924	membrane
HVW76_02395	COG0439	Biotin carboxylase
HVW76_02400	COG0511	ligase activity, forming carbon-carbon bonds
HVW76_02410	COG0604	alcohol dehydrogenase
HVW76_02415	COG2200	EAL domain
HVW76_02415	COG2199	diguanylate cyclase activity
HVW76_02420	COG1077	Cell shape determining protein MreB Mrl
HVW76_02425	COG1792	Involved in formation and maintenance of cell shape
HVW76_02430	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
HVW76_02435	COG0424	maF-like protein
HVW76_02440	COG1530	ribonuclease E activity
HVW76_02445	COG3164	Protein of unknown function
HVW76_02450	COG0312	modulator of DNA gyrase
HVW76_02455	COG0583	DNA-binding transcription factor activity
HVW76_02475	COG2732	(Barnase) inhibitor
HVW76_02495	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HVW76_02500	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HVW76_02505	COG3105	Protein conserved in bacteria
HVW76_02510	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
HVW76_02525	COG0625	glutathione transferase activity
HVW76_02530	COG2969	positive regulation of protein catabolic process
HVW76_02535	COG3069	C4-dicarboxylate transmembrane transporter activity
HVW76_02565	COG2731	YhcH YjgK YiaL family protein
HVW76_02570	COG4804	nuclease activity
HVW76_02575	COG0493	'glutamate synthase
HVW76_02580	COG0070	glutamate synthase
HVW76_02580	COG0069	glutamate synthase activity
HVW76_02580	COG0067	glutamate synthase
HVW76_02585	COG1242	4 iron, 4 sulfur cluster binding
HVW76_02590	COG5002	protein histidine kinase activity
HVW76_02590	COG0784	Response regulator, receiver
HVW76_02590	COG2198	Histidine kinase
HVW76_02595	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
HVW76_02605	COG0515	serine threonine protein kinase
HVW76_02610	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HVW76_02625	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HVW76_02630	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
HVW76_02635	COG1137	ATPase activity
HVW76_02640	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
HVW76_02645	COG3117	lipopolysaccharide transmembrane transporter activity
HVW76_02650	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
HVW76_02655	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HVW76_02655	COG0517	IMP dehydrogenase activity
HVW76_02660	COG0530	calcium, potassium:sodium antiporter activity
HVW76_02665	COG1127	ABC transporter
HVW76_02670	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HVW76_02675	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HVW76_02680	COG2854	intermembrane phospholipid transfer
HVW76_02685	COG3113	response to antibiotic
HVW76_02690	COG5007	Belongs to the BolA IbaG family
HVW76_02700	COG3423	Transcriptional regulator
HVW76_02705	COG0142	geranyltranstransferase activity
HVW76_02720	COG0697	spore germination
HVW76_02730	COG2027	D-alanyl-D-alanine carboxypeptidase
HVW76_02735	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HVW76_02740	COG1534	Rna-binding protein
HVW76_02750	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HVW76_02755	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HVW76_02765	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HVW76_02775	COG2194	sulfuric ester hydrolase activity
HVW76_02795	COG0195	Participates in both transcription termination and antitermination
HVW76_02835	COG0513	Belongs to the DEAD box helicase family
HVW76_02840	COG0814	amino acid
HVW76_02845	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HVW76_02850	COG0826	peptidase U32
HVW76_02855	COG0826	peptidase U32
HVW76_02860	COG3154	lipid carrier protein
HVW76_02865	COG3153	acetyltransferase
HVW76_02880	COG0693	protein deglycase activity
HVW76_02885	COG0702	epimerase
HVW76_02890	COG0701	Predicted permease
HVW76_02895	COG2823	Periplasmic or secreted lipoprotein
HVW76_02915	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HVW76_02920	COG3539	Fimbrial protein
HVW76_02925	COG3188	usher protein
HVW76_02930	COG3121	Chaperone
HVW76_02935	COG3539	Fimbrial protein
HVW76_02940	COG0363	glucosamine-6-phosphate deaminase activity
HVW76_02945	COG3716	PTS system mannose fructose sorbose family IID component
HVW76_02950	COG3715	PTS system
HVW76_02955	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HVW76_02965	COG2222	sugar isomerase
HVW76_02970	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HVW76_02975	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HVW76_02980	COG3716	PTS system mannose fructose sorbose family IID component
HVW76_02990	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HVW76_03000	COG1349	DNA-binding transcription factor activity
HVW76_03010	COG2002	toxin-antitoxin pair type II binding
HVW76_03015	COG2721	sulfolactate sulfo-lyase activity
HVW76_03020	COG2271	Major facilitator Superfamily
HVW76_03030	COG2084	Dehydrogenase
HVW76_03035	COG1929	Belongs to the glycerate kinase type-1 family
HVW76_03060	COG0583	DNA-binding transcription factor activity
HVW76_03065	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HVW76_03075	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HVW76_03080	COG1882	Formate acetyltransferase
HVW76_03085	COG0251	oxidation-reduction process
HVW76_03090	COG1760	l-serine dehydratase
HVW76_03095	COG0814	amino acid
HVW76_03110	COG1741	Belongs to the pirin family
HVW76_03115	COG0583	DNA-binding transcription factor activity
HVW76_03120	COG3152	Membrane
HVW76_03125	COG3152	Membrane
HVW76_03130	COG0435	Glutathione S-transferase
HVW76_03135	COG2259	Doxx family
HVW76_03145	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
HVW76_03150	COG4575	ribosome binding
HVW76_03155	COG1422	Protein of unknown function (DUF1090)
HVW76_03165	COG0586	Pfam SNARE associated Golgi protein
HVW76_03170	COG2186	Transcriptional regulator
HVW76_03175	COG2271	Major facilitator Superfamily
HVW76_03185	COG2721	sulfolactate sulfo-lyase activity
HVW76_03195	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
HVW76_03200	COG0861	Integral membrane protein TerC family
HVW76_03205	COG0673	inositol 2-dehydrogenase activity
HVW76_03210	COG2949	membrane
HVW76_03215	COG1451	nucleotide metabolic process
HVW76_03230	COG5499	transcription regulator containing HTH domain
HVW76_03235	COG1902	pentaerythritol trinitrate reductase activity
HVW76_03235	COG0446	pyridine nucleotide-disulphide oxidoreductase
HVW76_03240	COG3408	Glycogen debranching enzyme
HVW76_03240	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
HVW76_03250	COG0531	amino acid
HVW76_03255	COG2731	YhcH YjgK YiaL family protein
HVW76_03260	COG3250	beta-galactosidase activity
HVW76_03265	COG1609	Transcriptional regulator
HVW76_03270	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HVW76_03280	COG0840	transmembrane signaling receptor activity
HVW76_03285	COG1695	Transcriptional regulator
HVW76_03290	COG2375	cellular response to nickel ion
HVW76_03305	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HVW76_03310	COG0358	DNA primase activity
HVW76_03315	COG0828	Belongs to the bacterial ribosomal protein bS21 family
HVW76_03325	COG0471	metal ion transport
HVW76_03330	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HVW76_03335	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
HVW76_03340	COG0583	DNA-binding transcription factor activity
HVW76_03350	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HVW76_03365	COG4991	sh3 domain protein
HVW76_03370	COG3025	triphosphatase activity
HVW76_03395	COG2268	Band 7 protein
HVW76_03400	COG1585	Membrane protein implicated in regulation of membrane protease activity
HVW76_03430	COG3384	dioxygenase
HVW76_03435	COG0754	glutathionylspermidine amidase activity
HVW76_03445	COG1538	Outer membrane efflux protein
HVW76_03450	COG0494	nUDIX hydrolase
HVW76_03455	COG3151	Protein conserved in bacteria
HVW76_03460	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HVW76_03465	COG3150	esterase
HVW76_03470	COG0187	DNA topoisomerase II activity
HVW76_03475	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
HVW76_03480	COG2249	NAD(P)H dehydrogenase (quinone) activity
HVW76_03485	COG0642	Histidine kinase
HVW76_03490	COG0745	RESPONSE REGULATOR receiver
HVW76_03495	COG3111	PFAM Bacterial OB fold (BOF) protein
HVW76_03500	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
HVW76_03505	COG4166	transmembrane transport
HVW76_03510	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HVW76_03515	COG0204	Acyl-transferase
HVW76_03520	COG2132	Multicopper oxidase
HVW76_03525	COG1032	radical SAM domain protein
HVW76_03530	COG4238	major outer membrane lipoprotein
HVW76_03540	COG0656	L-ascorbic acid biosynthetic process
HVW76_03545	COG1979	alcohol dehydrogenase
HVW76_03550	COG2207	Transcriptional regulator
HVW76_03555	COG0586	Pfam SNARE associated Golgi protein
HVW76_03560	COG0626	cystathionine gamma-synthase activity
HVW76_03565	COG0811	peptide transport
HVW76_03570	COG0848	biopolymer transport protein
HVW76_03575	COG1028	Short-chain dehydrogenase reductase Sdr
HVW76_03585	COG0667	Aldo Keto reductase
HVW76_03600	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
HVW76_03605	COG0437	4 iron, 4 sulfur cluster binding
HVW76_03610	COG5557	Pfam Polysulphide reductase, NrfD
HVW76_03615	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
HVW76_03620	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
HVW76_03625	COG1773	rubredoxin
HVW76_03635	COG0298	carbon dioxide binding
HVW76_03640	COG0625	glutathione transferase activity
HVW76_03645	COG0754	glutathionylspermidine amidase activity
HVW76_03650	COG0306	phosphate transporter
HVW76_03655	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HVW76_03660	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HVW76_03665	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HVW76_03670	COG2244	polysaccharide biosynthetic process
HVW76_03680	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
HVW76_03685	COG0795	lipopolysaccharide-transporting ATPase activity
HVW76_03695	COG0156	8-amino-7-oxononanoate synthase activity
HVW76_03700	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HVW76_03710	COG0318	PFAM AMP-dependent synthetase and ligase
HVW76_03715	COG0456	acetyltransferase
HVW76_03720	COG2186	Transcriptional regulator
HVW76_03725	COG0277	FAD linked oxidase domain protein
HVW76_03730	COG0277	FAD linked oxidase domain protein
HVW76_03735	COG0247	lactate metabolic process
HVW76_03740	COG3193	protein, possibly involved in utilization of glycolate and propanediol
HVW76_03745	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
HVW76_03750	COG1620	l-lactate permease
HVW76_03755	COG3064	Membrane
HVW76_03770	COG3031	protein transport across the cell outer membrane
HVW76_03780	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HVW76_03785	COG1459	type II secretion system
HVW76_03790	COG2165	general secretion pathway protein
HVW76_03805	COG4795	General secretion pathway protein
HVW76_03820	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
HVW76_03880	COG0582	viral genome integration into host DNA
HVW76_03890	COG1811	Na channel or pump
HVW76_03895	COG1982	Orn Lys Arg decarboxylase major
HVW76_03900	COG2211	Major facilitator Superfamily
HVW76_03915	COG1194	a g-specific adenine glycosylase
HVW76_03925	COG3171	Protein conserved in bacteria
HVW76_03935	COG0252	asparaginase activity
HVW76_03945	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HVW76_03960	COG0762	integral membrane protein
HVW76_03965	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HVW76_03970	COG2805	Type II/IV secretion system protein
HVW76_03985	COG0189	ligase activity
HVW76_03990	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HVW76_03995	COG2356	endonuclease I
HVW76_04005	COG2814	Major facilitator Superfamily
HVW76_04025	COG1166	arginine decarboxylase activity
HVW76_04040	COG0501	Belongs to the peptidase M48B family
HVW76_04045	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HVW76_04050	COG0330	HflC and HflK could
HVW76_04055	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HVW76_04060	COG2213	PTS system mannitol-specific
HVW76_04065	COG1063	alcohol dehydrogenase
HVW76_04070	COG1494	fructose-1,6-bisphosphatase
HVW76_04080	COG1072	(Pantothenic acid kinase))
HVW76_04090	COG1122	ATPase activity
HVW76_04120	COG0191	fructose-bisphosphate aldolase activity
HVW76_04125	COG0668	transmembrane transport
HVW76_04130	COG1279	arginine transmembrane transporter activity
HVW76_04135	COG2968	Membrane
HVW76_04140	COG0583	DNA-binding transcription factor activity
HVW76_04145	COG0427	acetyl-CoA hydrolase
HVW76_04150	COG1024	Enoyl-CoA hydratase
HVW76_04155	COG1703	isobutyryl-CoA mutase activity
HVW76_04160	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HVW76_04160	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HVW76_04180	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HVW76_04190	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HVW76_04210	COG0006	proline dipeptidase activity
HVW76_04215	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HVW76_04220	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HVW76_04245	COG2723	6-phospho-beta-galactosidase activity
HVW76_04255	COG1272	protein, Hemolysin III
HVW76_04265	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
HVW76_04275	COG0716	FMN binding
HVW76_04280	COG4974	Belongs to the 'phage' integrase family
HVW76_04285	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HVW76_04290	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HVW76_04320	COG2233	PERMEase
HVW76_04330	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HVW76_04335	COG2252	PERMEase
HVW76_04340	COG0402	S-adenosylhomocysteine deaminase activity
HVW76_04345	COG2233	PERMEase
HVW76_04350	COG2080	2 iron, 2 sulfur cluster binding
HVW76_04350	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HVW76_04355	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
HVW76_04360	COG0402	S-adenosylhomocysteine deaminase activity
HVW76_04365	COG0493	'glutamate synthase
HVW76_04365	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HVW76_04370	COG2068	MobA-Related Protein
HVW76_04375	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HVW76_04380	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
HVW76_04380	COG3608	succinylglutamate desuccinylase aspartoacylase
HVW76_04385	COG0549	Belongs to the carbamate kinase family
HVW76_04395	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HVW76_04400	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HVW76_04405	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HVW76_04415	COG2080	2 iron, 2 sulfur cluster binding
HVW76_04420	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
HVW76_04425	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HVW76_04430	COG4942	peptidase
HVW76_04440	COG3387	PFAM Glycoside hydrolase 15-related
HVW76_04450	COG2207	Transcriptional regulator
HVW76_04550	COG2197	response regulator
HVW76_04555	COG0741	lytic transglycosylase activity
HVW76_04565	COG3710	Transcriptional regulator
HVW76_04565	COG0457	Tetratricopeptide repeat
HVW76_04570	COG0457	Tetratricopeptide repeat
HVW76_04595	COG3710	Transcriptional regulator
HVW76_04600	COG2771	luxR family
HVW76_04605	COG0814	amino acid
HVW76_04610	COG0183	Belongs to the thiolase family
HVW76_04620	COG1028	Short-chain dehydrogenase reductase Sdr
HVW76_04625	COG2814	Major facilitator Superfamily
HVW76_04630	COG1794	racemase activity, acting on amino acids and derivatives
HVW76_04635	COG0583	DNA-binding transcription factor activity
HVW76_04645	COG1609	Transcriptional regulator
HVW76_04660	COG0667	Aldo Keto reductase
HVW76_04670	COG0861	Integral membrane protein TerC family
HVW76_04685	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
HVW76_04700	COG2165	general secretion pathway protein
HVW76_04705	COG4795	General secretion pathway protein
HVW76_04715	COG4967	type IV pilus modification protein PilV
HVW76_04720	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
HVW76_04725	COG1025	Belongs to the peptidase M16 family
HVW76_04730	COG1074	ATP-dependent DNA helicase activity
HVW76_04735	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HVW76_04740	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
HVW76_04740	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HVW76_04745	COG0860	N-Acetylmuramoyl-L-alanine amidase
HVW76_04765	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
HVW76_04770	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HVW76_04775	COG2166	iron-sulfur cluster assembly
HVW76_04780	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HVW76_04790	COG0583	DNA-binding transcription factor activity
HVW76_04795	COG2363	Small membrane protein
HVW76_04805	COG1349	DNA-binding transcription factor activity
HVW76_04815	COG1070	Carbohydrate kinase
HVW76_04825	COG0738	Major facilitator superfamily
HVW76_04830	COG0235	Class ii aldolase
HVW76_04835	COG1454	alcohol dehydrogenase
HVW76_04845	COG1760	l-serine dehydratase
HVW76_04850	COG0814	amino acid
HVW76_04855	COG1611	Belongs to the LOG family
HVW76_04870	COG3098	single-species biofilm formation
HVW76_04875	COG0564	pseudouridine synthase activity
HVW76_04880	COG0716	FMN binding
HVW76_04885	COG2271	Major facilitator Superfamily
HVW76_04890	COG4948	Mandelate Racemase Muconate Lactonizing
HVW76_04895	COG4948	Mandelate Racemase Muconate Lactonizing
HVW76_04900	COG3437	response regulator, receiver
HVW76_04900	COG2205	protein histidine kinase activity
HVW76_04900	COG4999	Histidine kinase
HVW76_04900	COG3850	Histidine kinase
HVW76_04910	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HVW76_04915	COG2336	PFAM SpoVT AbrB
HVW76_04920	COG2337	Toxic component of a toxin-antitoxin (TA) module
HVW76_04925	COG3956	TIGRFAM MazG family protein
HVW76_04940	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
HVW76_04950	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
HVW76_04960	COG0602	queuosine metabolic process
HVW76_04965	COG1070	Carbohydrate kinase
HVW76_04970	COG2223	nitrite transmembrane transporter activity
HVW76_04975	COG1028	Short-chain dehydrogenase reductase Sdr
HVW76_04980	COG0277	FAD linked oxidase domain protein
HVW76_04985	COG0477	Major facilitator Superfamily
HVW76_04990	COG2086	electron transfer activity
HVW76_04995	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
HVW76_05000	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
HVW76_05005	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
HVW76_05010	COG0644	oxidoreductase
HVW76_05015	COG0720	synthase
HVW76_05040	COG3385	transposase activity
HVW76_05045	COG1203	CRISPR-associated helicase, Cas3
HVW76_05060	COG1857	crispr-associated protein
HVW76_05075	COG1518	maintenance of DNA repeat elements
HVW76_05080	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HVW76_05085	COG2234	aminopeptidase activity
HVW76_05140	COG1388	LysM domain
HVW76_05140	COG4942	peptidase
HVW76_05145	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HVW76_05160	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HVW76_05170	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HVW76_05190	COG3604	Transcriptional regulator
HVW76_05195	COG0309	Hydrogenase expression formation protein (HypE)
HVW76_05200	COG0409	Hydrogenase expression formation protein
HVW76_05205	COG0298	carbon dioxide binding
HVW76_05210	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
HVW76_05215	COG0375	protein maturation
HVW76_05225	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HVW76_05230	COG0651	ATP synthesis coupled electron transport
HVW76_05235	COG0650	Formate hydrogenlyase subunit 4
HVW76_05240	COG3261	NADH dehydrogenase
HVW76_05240	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
HVW76_05245	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HVW76_05250	COG3260	NADH ubiquinone oxidoreductase 20
HVW76_05260	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
HVW76_05265	COG2723	6-phospho-beta-galactosidase activity
HVW76_05270	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HVW76_05270	COG1263	PTS System
HVW76_05275	COG1609	Transcriptional regulator
HVW76_05280	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HVW76_05285	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
HVW76_05305	COG0517	IMP dehydrogenase activity
HVW76_05305	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HVW76_05310	COG1349	DNA-binding transcription factor activity
HVW76_05315	COG4578	phosphoenolpyruvate-dependent sugar phosphotransferase system
HVW76_05320	COG1028	Short-chain dehydrogenase reductase Sdr
HVW76_05330	COG3732	PTS system glucitol sorbitol-specific
HVW76_05335	COG3730	PTS system glucitol sorbitol-specific
HVW76_05340	COG2951	lytic endotransglycosylase activity
HVW76_05345	COG1546	Belongs to the CinA family
HVW76_05365	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
HVW76_05395	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HVW76_05400	COG1238	metal cluster binding
HVW76_05415	COG2814	Major facilitator Superfamily
HVW76_05420	COG1566	PFAM secretion protein HlyD family protein
HVW76_05425	COG1846	Transcriptional regulator
HVW76_05435	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
HVW76_05440	COG2814	Major facilitator Superfamily
HVW76_05445	COG2113	Glycine betaine
HVW76_05450	COG4176	ABC-type proline glycine betaine transport system permease component
HVW76_05455	COG4175	Glycine betaine
HVW76_05460	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HVW76_05475	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HVW76_05480	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HVW76_05490	COG4575	ribosome binding
HVW76_05505	COG2916	Histone family protein nucleoid-structuring protein H-NS
HVW76_05510	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HVW76_05515	COG0640	Transcriptional regulator
HVW76_05520	COG0401	homolog of Blt101
HVW76_05525	COG1652	LysM domain
HVW76_05530	COG1802	Transcriptional regulator
HVW76_05535	COG1113	amino acid transport
HVW76_05540	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HVW76_05545	COG1012	belongs to the aldehyde dehydrogenase family
HVW76_05550	COG0579	oxidoreductase
HVW76_05600	COG1475	DNA binding
HVW76_05610	COG0582	viral genome integration into host DNA
HVW76_05625	COG2867	negative regulation of translational initiation
HVW76_05635	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HVW76_05640	COG0497	DNA recombination
HVW76_05655	COG4536	flavin adenine dinucleotide binding
HVW76_05660	COG4137	Cytochrome C assembly protein
HVW76_05665	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HVW76_05690	COG2885	chlorophyll binding
HVW76_05695	COG2199	diguanylate cyclase activity
HVW76_05710	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HVW76_05715	COG1605	Chorismate mutase
HVW76_05715	COG0287	Prephenate dehydrogenase
HVW76_05720	COG1605	Chorismate mutase
HVW76_05720	COG0077	Prephenate dehydratase
HVW76_05730	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HVW76_05735	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HVW76_05740	COG0564	pseudouridine synthase activity
HVW76_05750	COG0542	response to heat
HVW76_05775	COG0477	Major facilitator Superfamily
HVW76_05780	COG5544	Lipoprotein
HVW76_05785	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HVW76_05790	COG0045	succinate-CoA ligase (ADP-forming) activity
HVW76_05790	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HVW76_05790	COG1042	CoA-binding domain protein
HVW76_05800	COG3118	belongs to the thioredoxin family
HVW76_05805	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HVW76_05820	COG1280	lysine exporter protein (LysE YggA)
HVW76_05825	COG0583	DNA-binding transcription factor activity
HVW76_05830	COG0513	Belongs to the DEAD box helicase family
HVW76_05840	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HVW76_05850	COG1595	DNA-templated transcription, initiation
HVW76_05855	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
HVW76_05860	COG3026	antisigma factor binding
HVW76_05865	COG3086	response to oxidative stress
HVW76_05875	COG0681	Belongs to the peptidase S26 family
HVW76_05895	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
HVW76_05910	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HVW76_05915	COG1737	Transcriptional regulator
HVW76_05920	COG0560	Phosphoserine phosphatase
HVW76_05925	COG0590	tRNA wobble adenosine to inosine editing
HVW76_05935	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HVW76_05935	COG0047	phosphoribosylformylglycinamidine synthase activity
HVW76_05940	COG2205	protein histidine kinase activity
HVW76_05945	COG3170	Tfp pilus assembly protein FimV
HVW76_05950	COG2204	response regulator
HVW76_05955	COG0347	Belongs to the P(II) protein family
HVW76_05960	COG1017	nitric oxide dioxygenase activity
HVW76_05960	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HVW76_05970	COG1940	carbohydrate kinase activity
HVW76_05975	COG0457	Tetratricopeptide repeat
HVW76_05980	COG1879	ABC-type sugar transport system periplasmic component
HVW76_05985	COG1129	ABC transporter
HVW76_05990	COG1172	Belongs to the binding-protein-dependent transport system permease family
HVW76_05995	COG1063	alcohol dehydrogenase
HVW76_06000	COG2017	converts alpha-aldose to the beta-anomer
HVW76_06005	COG2259	Doxx family
HVW76_06030	COG4638	Rieske (2fe-2S)
HVW76_06035	COG0583	DNA-binding transcription factor activity
HVW76_06040	COG2814	Major facilitator Superfamily
HVW76_06045	COG3711	transcriptional antiterminator
HVW76_06050	COG1073	alpha beta
HVW76_06055	COG0483	inositol monophosphate 1-phosphatase activity
HVW76_06075	COG0822	iron-sulfur transferase activity
HVW76_06095	COG0633	Ferredoxin
HVW76_06100	COG2975	iron-sulfur cluster assembly
HVW76_06120	COG2897	thiosulfate sulfurtransferase activity
HVW76_06125	COG2373	Large extracellular alpha-helical protein
HVW76_06130	COG4953	penicillin-binding protein 1C
HVW76_06135	COG0243	molybdopterin cofactor binding
HVW76_06140	COG0437	4 iron, 4 sulfur cluster binding
HVW76_06145	COG3302	dmso reductase anchor subunit
HVW76_06180	COG2976	Protein conserved in bacteria
HVW76_06195	COG1645	bacterial-type flagellum-dependent swarming motility
HVW76_06205	COG0516	GMP reductase activity
HVW76_06205	COG0517	IMP dehydrogenase activity
HVW76_06215	COG0582	viral genome integration into host DNA
HVW76_06255	COG3846	protein secretion by the type IV secretion system
HVW76_06260	COG3093	addiction module antidote protein HigA
HVW76_06300	COG1061	Type III restriction enzyme res subunit
HVW76_06310	COG3133	Outer membrane lipoprotein
HVW76_06325	COG2200	EAL domain
HVW76_06330	COG0248	Ppx GppA phosphatase
HVW76_06335	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
HVW76_06340	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HVW76_06355	COG2233	PERMEase
HVW76_06365	COG1393	Belongs to the ArsC family
HVW76_06370	COG4783	chaperone-mediated protein folding
HVW76_06375	COG0628	permease
HVW76_06380	COG2116	formate transmembrane transporter activity
HVW76_06385	COG3604	Transcriptional regulator
HVW76_06395	COG3260	NADH ubiquinone oxidoreductase 20
HVW76_06400	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HVW76_06405	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
HVW76_06405	COG3261	NADH dehydrogenase
HVW76_06410	COG0651	ATP synthesis coupled electron transport
HVW76_06415	COG4237	Hydrogenase 4 membrane
HVW76_06420	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HVW76_06425	COG0650	Formate hydrogenlyase subunit 4
HVW76_06430	COG0651	ATP synthesis coupled electron transport
HVW76_06435	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HVW76_06440	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HVW76_06445	COG2716	regulation of RNA biosynthetic process
HVW76_06455	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
HVW76_06465	COG2321	neutral zinc metallopeptidase
HVW76_06475	COG0400	carboxylic ester hydrolase activity
HVW76_06490	COG1393	Belongs to the ArsC family
HVW76_06500	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HVW76_06505	COG3850	Histidine kinase
HVW76_06510	COG0493	'glutamate synthase
HVW76_06510	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HVW76_06520	COG5342	invasion associated locus B
HVW76_06525	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HVW76_06530	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HVW76_06535	COG0281	malic enzyme
HVW76_06535	COG0280	phosphate acetyltransferase
HVW76_06540	COG4810	utilization protein
HVW76_06545	COG4917	ethanolamine utilization protein
HVW76_06550	COG4766	ethanolamine catabolic process
HVW76_06555	COG4812	Cobalamin adenosyltransferase
HVW76_06560	COG0280	phosphate acetyltransferase
HVW76_06565	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
HVW76_06570	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
HVW76_06575	COG1012	belongs to the aldehyde dehydrogenase family
HVW76_06580	COG4820	ethanolamine utilization protein (EutJ)
HVW76_06585	COG1454	alcohol dehydrogenase
HVW76_06590	COG3192	ethanolamine utilization protein
HVW76_06595	COG4819	ethanolamine utilization protein
HVW76_06600	COG4303	Ethanolamine ammonia lyase large subunit
HVW76_06610	COG4816	utilization protein
HVW76_06615	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
HVW76_06620	COG2207	Transcriptional regulator
HVW76_06630	COG0860	N-Acetylmuramoyl-L-alanine amidase
HVW76_06650	COG2837	iron assimilation
HVW76_06655	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HVW76_06660	COG1263	PTS System
HVW76_06660	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HVW76_06675	COG1028	Short-chain dehydrogenase reductase Sdr
HVW76_06680	COG4150	thiosulfate binding
HVW76_06685	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
HVW76_06690	COG4208	sulfate ABC transporter
HVW76_06695	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
HVW76_06700	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HVW76_06715	COG2190	(PTS) system
HVW76_06720	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HVW76_06725	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HVW76_06730	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HVW76_06750	COG3530	Putative quorum-sensing-regulated virulence factor
HVW76_06755	COG0385	Bile acid
HVW76_06760	COG0583	DNA-binding transcription factor activity
HVW76_06810	COG3415	Transposase
HVW76_06815	COG3415	Transposase
HVW76_06830	COG2199	diguanylate cyclase activity
HVW76_06830	COG2200	EAL domain
HVW76_06835	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HVW76_06860	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HVW76_06865	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HVW76_06870	COG0006	proline dipeptidase activity
HVW76_06875	COG1363	Peptidase, m42
HVW76_06880	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HVW76_06880	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HVW76_06880	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HVW76_06885	COG2207	Transcriptional regulator
HVW76_06890	COG3279	Response regulator of the LytR AlgR family
HVW76_06895	COG3275	phosphorelay sensor kinase activity
HVW76_06900	COG0436	Aminotransferase
HVW76_06910	COG1560	Kdo2-lipid A biosynthetic process
HVW76_06935	COG0028	Belongs to the TPP enzyme family
HVW76_06940	COG0679	Auxin Efflux Carrier
HVW76_06945	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HVW76_06950	COG2205	protein histidine kinase activity
HVW76_06950	COG0784	Response regulator, receiver
HVW76_06950	COG2198	Histidine kinase
HVW76_06950	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HVW76_06955	COG2197	response regulator
HVW76_06960	COG1566	PFAM secretion protein HlyD family protein
HVW76_06965	COG0477	Major facilitator Superfamily
HVW76_07045	COG0582	viral genome integration into host DNA
HVW76_07055	COG2116	formate transmembrane transporter activity
HVW76_07060	COG2853	Lipoprotein
HVW76_07070	COG2067	long-chain fatty acid transport protein
HVW76_07075	COG3691	Protein conserved in bacteria
HVW76_07090	COG2062	phosphohistidine phosphatase, SixA
HVW76_07095	COG3539	Fimbrial protein
HVW76_07100	COG3188	usher protein
HVW76_07105	COG3121	Chaperone
HVW76_07110	COG3539	Fimbrial protein
HVW76_07115	COG3539	Fimbrial protein
HVW76_07120	COG3539	Fimbrial protein
HVW76_07135	COG2890	protein-(glutamine-N5) methyltransferase activity
HVW76_07150	COG0730	response to heat
HVW76_07155	COG3101	peptidyl-lysine hydroxylation
HVW76_07170	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HVW76_07175	COG2814	Major facilitator Superfamily
HVW76_07190	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HVW76_07200	COG0586	Pfam SNARE associated Golgi protein
HVW76_07210	COG0285	dihydrofolate synthase activity
HVW76_07215	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
HVW76_07220	COG1286	toxin biosynthetic process
HVW76_07225	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HVW76_07230	COG0163	prenyltransferase activity
HVW76_07235	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HVW76_07240	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HVW76_07245	COG4215	(ABC) transporter
HVW76_07250	COG4160	amino acid transport
HVW76_07255	COG4598	ABC transporter
HVW76_07260	COG5464	transposase or invertase
HVW76_07265	COG1090	epimerase
HVW76_07270	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HVW76_07275	COG0625	glutathione transferase activity
HVW76_07280	COG0625	glutathione transferase activity
HVW76_07285	COG0622	Phosphoesterase
HVW76_07290	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
HVW76_07295	COG1288	antiporter activity
HVW76_07300	COG0857	belongs to the CobB CobQ family
HVW76_07300	COG0280	phosphate acetyltransferase
HVW76_07305	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HVW76_07320	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HVW76_07325	COG0471	metal ion transport
HVW76_07325	COG0490	domain, Protein
HVW76_07335	COG0436	Aminotransferase
HVW76_07340	COG0583	DNA-binding transcription factor activity
HVW76_07360	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
HVW76_07365	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
HVW76_07370	COG1034	ATP synthesis coupled electron transport
HVW76_07385	COG0839	Belongs to the complex I subunit 6 family
HVW76_07395	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HVW76_07400	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HVW76_07420	COG5160	protein modification by small protein removal
HVW76_07430	COG2153	protein acetylation
HVW76_07435	COG4575	ribosome binding
HVW76_07440	COG1169	isochorismate synthase
HVW76_07455	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
HVW76_07465	COG0318	PFAM AMP-dependent synthetase and ligase
HVW76_07530	COG1414	Transcriptional regulator
HVW76_07540	COG2271	Major facilitator Superfamily
HVW76_07555	COG5464	transposase or invertase
HVW76_07560	COG0247	lactate metabolic process
HVW76_07570	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HVW76_07575	COG2271	Major facilitator Superfamily
HVW76_07580	COG0584	glycerophosphoryl diester phosphodiesterase
HVW76_07590	COG0583	DNA-binding transcription factor activity
HVW76_07595	COG2814	Major facilitator Superfamily
HVW76_07600	COG3642	lipopolysaccharide core region biosynthetic process
HVW76_07605	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HVW76_07610	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HVW76_07615	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HVW76_07620	COG3468	outer membrane autotransporter barrel domain protein
HVW76_07630	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HVW76_07635	COG4685	Uncharacterized protein conserved in bacteria (DUF2138)
HVW76_07640	COG3234	Protein of unknown function (DUF1175)
HVW76_07645	COG2373	Large extracellular alpha-helical protein
HVW76_07650	COG5445	Predicted secreted protein (DUF2300)
HVW76_07655	COG4676	Protein conserved in bacteria
HVW76_07660	COG0183	Belongs to the thiolase family
HVW76_07665	COG2031	fatty acid transporter
HVW76_07670	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HVW76_07675	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HVW76_07680	COG2204	response regulator
HVW76_07685	COG3852	Histidine kinase
HVW76_07690	COG2205	protein histidine kinase activity
HVW76_07690	COG0784	Response regulator, receiver
HVW76_07695	COG2197	response regulator
HVW76_07700	COG2198	Histidine kinase
HVW76_07700	COG0642	Histidine kinase
HVW76_07705	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HVW76_07710	COG1477	protein flavinylation
HVW76_07715	COG2169	Transcriptional regulator
HVW76_07715	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HVW76_07720	COG3145	DNA-N1-methyladenine dioxygenase activity
HVW76_07725	COG4615	Cyclic peptide transporter
HVW76_07745	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
HVW76_07745	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HVW76_07750	COG3062	negative regulation of establishment of protein localization
HVW76_07760	COG0437	4 iron, 4 sulfur cluster binding
HVW76_07765	COG0348	domain, Protein
HVW76_07770	COG3043	anaerobic respiration
HVW76_07775	COG3005	denitrification pathway
HVW76_07780	COG4133	protoheme IX ABC transporter activity
HVW76_07785	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HVW76_07790	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HVW76_07795	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HVW76_07805	COG1138	Cytochrome C-type biogenesis protein
HVW76_07810	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HVW76_07815	COG3088	subunit of a heme lyase
HVW76_07815	COG4235	cytochrome complex assembly
HVW76_07820	COG2197	response regulator
HVW76_07825	COG3468	outer membrane autotransporter barrel domain protein
HVW76_07835	COG3083	sulfuric ester hydrolase activity
HVW76_07855	COG1061	Type III restriction enzyme res subunit
HVW76_07860	COG1187	pseudouridine synthase activity
HVW76_07865	COG2814	Major facilitator Superfamily
HVW76_07875	COG4172	Belongs to the ABC transporter superfamily
HVW76_07880	COG4239	(ABC) transporter, permease
HVW76_07885	COG4174	ABC transporter (Permease)
HVW76_07890	COG4166	transmembrane transport
HVW76_07895	COG2200	EAL domain
HVW76_07900	COG0791	NLP P60 protein
HVW76_07905	COG0671	phosphoesterase, PA-phosphatase related
HVW76_07910	COG0523	cobalamin synthesis protein
HVW76_07915	COG0246	Mannitol dehydrogenase
HVW76_07930	COG2814	Major facilitator Superfamily
HVW76_07935	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HVW76_07935	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HVW76_07940	COG1105	Belongs to the carbohydrate kinase PfkB family
HVW76_07945	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HVW76_07945	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
HVW76_07945	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HVW76_07950	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HVW76_07955	COG2313	pseudouridylate synthase activity
HVW76_07960	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HVW76_07965	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HVW76_07975	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HVW76_07980	COG1522	sequence-specific DNA binding
HVW76_07980	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HVW76_07990	COG2855	membrane
HVW76_07995	COG0583	DNA-binding transcription factor activity
HVW76_08000	COG0833	amino acid
HVW76_08005	COG4771	TonB-dependent receptor
HVW76_08010	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
HVW76_08020	COG2311	Membrane
HVW76_08025	COG1609	Transcriptional regulator
HVW76_08030	COG1879	ABC-type sugar transport system periplasmic component
HVW76_08035	COG1129	ABC transporter
HVW76_08040	COG4211	Belongs to the binding-protein-dependent transport system permease family
HVW76_08045	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
HVW76_08045	COG0167	dihydroorotate dehydrogenase activity
HVW76_08050	COG0493	'glutamate synthase
HVW76_08060	COG2949	membrane
HVW76_08070	COG1346	cytolysis
HVW76_08085	COG2271	Major facilitator Superfamily
HVW76_08100	COG0625	glutathione transferase activity
HVW76_08105	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HVW76_08110	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HVW76_08125	COG1028	Short-chain dehydrogenase reductase Sdr
HVW76_08130	COG0586	Pfam SNARE associated Golgi protein
HVW76_08140	COG1686	Belongs to the peptidase S11 family
HVW76_08145	COG0277	FAD linked oxidase domain protein
HVW76_08150	COG1472	Belongs to the glycosyl hydrolase 3 family
HVW76_08155	COG1732	Glycine betaine
HVW76_08160	COG1174	glycine betaine transport
HVW76_08165	COG1125	glycine betaine transport
HVW76_08170	COG1174	glycine betaine transport
HVW76_08180	COG0789	Transcriptional regulator
HVW76_08185	COG3275	phosphorelay sensor kinase activity
HVW76_08190	COG3279	Response regulator of the LytR AlgR family
HVW76_08195	COG4807	Protein conserved in bacteria
HVW76_08200	COG4808	Protein conserved in bacteria
HVW76_08205	COG4715	Zinc finger, swim domain protein
HVW76_08210	COG3552	Protein containing von Willebrand factor type A (VWA) domain
HVW76_08215	COG2425	protein containing a von Willebrand factor type A (vWA) domain
HVW76_08220	COG0714	Associated with various cellular activities
HVW76_08230	COG3831	ATPase activity
HVW76_08235	COG3831	ATPase activity
HVW76_08240	COG3831	ATPase activity
HVW76_08250	COG0489	protein tyrosine kinase activity
HVW76_08260	COG3539	Fimbrial protein
HVW76_08265	COG3121	Chaperone
HVW76_08270	COG3188	usher protein
HVW76_08275	COG3539	Fimbrial protein
HVW76_08280	COG5455	response to cobalt ion
HVW76_08300	COG0351	phosphomethylpyrimidine kinase
HVW76_08305	COG3757	hydrolase, family 25
HVW76_08310	COG2188	Transcriptional regulator
HVW76_08315	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HVW76_08320	COG1397	ADP-ribosylglycohydrolase
HVW76_08325	COG2211	Major facilitator Superfamily
HVW76_08330	COG1830	Aldolase
HVW76_08345	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HVW76_08350	COG3414	Phosphotransferase system galactitol-specific IIB component
HVW76_08355	COG3775	system Galactitol-specific IIC component
HVW76_08360	COG1063	alcohol dehydrogenase
HVW76_08390	COG3609	addiction module antidote protein, CC2985 family
HVW76_08400	COG0745	RESPONSE REGULATOR receiver
HVW76_08405	COG2205	protein histidine kinase activity
HVW76_08445	COG4245	von Willebrand factor, type A
HVW76_08450	COG0631	protein serine/threonine phosphatase activity
HVW76_08455	COG4248	protein with protein kinase and helix-hairpin-helix DNA-binding domains
HVW76_08460	COG0443	Heat shock 70 kDa protein
HVW76_08465	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
HVW76_08470	COG5001	Diguanylate cyclase
HVW76_08470	COG5002	protein histidine kinase activity
HVW76_08470	COG3447	MASE1 domain protein
HVW76_08475	COG0572	uridine kinase
HVW76_08485	COG2982	Protein involved in outer membrane biogenesis
HVW76_08500	COG1253	flavin adenine dinucleotide binding
HVW76_08510	COG1596	polysaccharide export
HVW76_08515	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HVW76_08520	COG3206	protein involved in exopolysaccharide biosynthesis
HVW76_08520	COG0489	protein tyrosine kinase activity
HVW76_08525	COG0463	Glycosyl transferase, family 2
HVW76_08530	COG1045	serine acetyltransferase
HVW76_08535	COG0438	transferase activity, transferring glycosyl groups
HVW76_08545	COG1216	Glycosyl transferase, family 2
HVW76_08550	COG0110	maltose O-acetyltransferase activity
HVW76_08555	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
HVW76_08560	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HVW76_08565	COG1051	belongs to the nudix hydrolase family
HVW76_08570	COG0297	glycogen (starch) synthase activity
HVW76_08575	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
HVW76_08575	COG0662	Cupin 2, conserved barrel domain protein
HVW76_08580	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HVW76_08585	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HVW76_08590	COG2244	polysaccharide biosynthetic process
HVW76_08595	COG2327	Polysaccharide pyruvyl transferase
HVW76_08600	COG0438	transferase activity, transferring glycosyl groups
HVW76_08610	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HVW76_08615	COG1088	dTDP-glucose 4,6-dehydratase activity
HVW76_08635	COG0438	transferase activity, transferring glycosyl groups
HVW76_08670	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HVW76_08675	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
HVW76_08705	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HVW76_08735	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HVW76_08740	COG0583	DNA-binding transcription factor activity
HVW76_08750	COG0531	amino acid
HVW76_08755	COG2391	methyltransferase activity
HVW76_08760	COG0425	Belongs to the sulfur carrier protein TusA family
HVW76_08765	COG2925	Exonuclease
HVW76_08770	COG1686	Belongs to the peptidase S11 family
HVW76_08780	COG1289	transmembrane transporter activity
HVW76_08800	COG2087	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate
HVW76_08815	COG1376	ErfK ybiS ycfS ynhG family protein
HVW76_08825	COG0583	DNA-binding transcription factor activity
HVW76_08830	COG0583	DNA-binding transcription factor activity
HVW76_08840	COG0534	Mate efflux family protein
HVW76_08850	COG0217	transcriptional regulatory protein
HVW76_08855	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HVW76_08860	COG0477	Major facilitator Superfamily
HVW76_08870	COG1388	LysM domain
HVW76_08870	COG4932	domain protein
HVW76_08870	COG2373	Large extracellular alpha-helical protein
HVW76_08890	COG3038	cytochrome b561
HVW76_08895	COG3443	Belongs to the bacterial solute-binding protein 9 family
HVW76_08910	COG2351	hydroxyisourate hydrolase activity
HVW76_08915	COG0745	RESPONSE REGULATOR receiver
HVW76_08920	COG2205	protein histidine kinase activity
HVW76_08935	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HVW76_08945	COG1418	mRNA catabolic process
HVW76_08950	COG0270	DNA (cytosine-5-)-methyltransferase activity
HVW76_08955	COG3727	T/G mismatch-specific endonuclease activity
HVW76_08960	COG0697	spore germination
HVW76_08965	COG2354	Protein conserved in bacteria
HVW76_08970	COG5475	Uncharacterized small protein (DUF2158)
HVW76_08975	COG3706	GGDEF domain
HVW76_08995	COG2197	response regulator
HVW76_09000	COG1684	flagellar biosynthetic protein fliR
HVW76_09005	COG1987	bacterial-type flagellum assembly
HVW76_09010	COG1338	Plays a role in the flagellum-specific transport system
HVW76_09015	COG3190	flagellar
HVW76_09020	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HVW76_09025	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HVW76_09030	COG1580	Controls the rotational direction of flagella during chemotaxis
HVW76_09035	COG3144	bacterial-type flagellum assembly
HVW76_09040	COG2882	bacterial-type flagellum organization
HVW76_09045	COG1157	protein secretion by the type III secretion system
HVW76_09050	COG1317	bacterial-type flagellum organization
HVW76_09055	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HVW76_09060	COG1766	The M ring may be actively involved in energy transduction
HVW76_09075	COG0454	-acetyltransferase
HVW76_09080	COG2135	peptidase activity
HVW76_09085	COG0425	Belongs to the sulfur carrier protein TusA family
HVW76_09090	COG2391	methyltransferase activity
HVW76_09100	COG0366	Alpha amylase catalytic
HVW76_09110	COG1516	flagellar protein fliS
HVW76_09115	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
HVW76_09125	COG1191	sigma factor activity
HVW76_09155	COG2197	response regulator
HVW76_09170	COG2197	response regulator
HVW76_09200	COG3318	Belongs to the UPF0149 family
HVW76_09200	COG3012	SEC-C Motif Domain Protein
HVW76_09205	COG0814	amino acid
HVW76_09215	COG1528	Iron-storage protein
HVW76_09235	COG1528	Iron-storage protein
HVW76_09240	COG1879	ABC-type sugar transport system periplasmic component
HVW76_09245	COG1129	ABC transporter
HVW76_09250	COG1172	Belongs to the binding-protein-dependent transport system permease family
HVW76_09255	COG1877	trehalose-phosphatase activity
HVW76_09265	COG0589	response to stress
HVW76_09280	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
HVW76_09285	COG1360	Flagellar Motor Protein
HVW76_09290	COG0643	Histidine kinase
HVW76_09290	COG2198	Histidine kinase
HVW76_09295	COG0835	chemotaxis
HVW76_09300	COG0840	transmembrane signaling receptor activity
HVW76_09305	COG0840	transmembrane signaling receptor activity
HVW76_09310	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
HVW76_09320	COG0745	RESPONSE REGULATOR receiver
HVW76_09325	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
HVW76_09330	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HVW76_09335	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HVW76_09345	COG3755	Protein conserved in bacteria
HVW76_09355	COG3102	Protein conserved in bacteria
HVW76_09365	COG3005	denitrification pathway
HVW76_09370	COG0243	molybdopterin cofactor binding
HVW76_09385	COG3788	relative of glutathione S-transferase, MAPEG superfamily
HVW76_09390	COG1801	Protein of unknown function DUF72
HVW76_09395	COG1335	isochorismatase
HVW76_09405	COG0494	nUDIX hydrolase
HVW76_09410	COG0217	transcriptional regulatory protein
HVW76_09440	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HVW76_09450	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
HVW76_09455	COG0739	heme binding
HVW76_09460	COG1560	Kdo2-lipid A biosynthetic process
HVW76_09465	COG0469	pyruvate kinase activity
HVW76_09470	COG1737	Transcriptional regulator
HVW76_09475	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HVW76_09480	COG0129	dihydroxy-acid dehydratase activity
HVW76_09485	COG0800	Aldolase
HVW76_09495	COG3141	response to X-ray
HVW76_09505	COG2979	Protein of unknown function (DUF533)
HVW76_09510	COG1770	oligopeptidase
HVW76_09515	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HVW76_09520	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HVW76_09530	COG2372	response to copper ion
HVW76_09535	COG1276	copper resistance
HVW76_09545	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HVW76_09565	COG3008	intermembrane lipid transfer
HVW76_09570	COG2995	paraquat-inducible protein a
HVW76_09575	COG1956	GAF domain-containing protein
HVW76_09585	COG0793	Belongs to the peptidase S41A family
HVW76_09595	COG2814	Major facilitator Superfamily
HVW76_09600	COG1414	Transcriptional regulator
HVW76_09630	COG2226	methyltransferase
HVW76_09645	COG3716	PTS system mannose fructose sorbose family IID component
HVW76_09650	COG3715	PTS system
HVW76_09655	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HVW76_09655	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HVW76_09660	COG1253	flavin adenine dinucleotide binding
HVW76_09665	COG2200	EAL domain
HVW76_09670	COG1760	l-serine dehydratase
HVW76_09680	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HVW76_09695	COG0251	oxidation-reduction process
HVW76_09700	COG1199	ATP-dependent helicase activity
HVW76_09705	COG1214	PFAM Peptidase M22, glycoprotease
HVW76_09710	COG3065	identical protein binding
HVW76_09715	COG0318	PFAM AMP-dependent synthetase and ligase
HVW76_09720	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
HVW76_09725	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HVW76_09730	COG4638	Rieske (2fe-2S)
HVW76_09735	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HVW76_09740	COG0473	3-isopropylmalate dehydrogenase activity
HVW76_09745	COG0583	DNA-binding transcription factor activity
HVW76_09755	COG3615	Tellurite resistance protein tehB
HVW76_09765	COG2261	transglycosylase associated protein
HVW76_09780	COG2199	diguanylate cyclase activity
HVW76_09780	COG2203	Gaf domain
HVW76_09785	COG3042	response to heat
HVW76_09790	COG3189	MarR family transcriptional regulator
HVW76_09795	COG2807	transmembrane transport
HVW76_09800	COG2207	Transcriptional regulator
HVW76_09815	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HVW76_09820	COG2199	diguanylate cyclase activity
HVW76_09825	COG2199	diguanylate cyclase activity
HVW76_09835	COG2766	serine protein kinase
HVW76_09840	COG3713	MltA-interacting MipA family protein
HVW76_09845	COG0656	L-ascorbic acid biosynthetic process
HVW76_09850	COG0676	glucose-6-phosphate 1-epimerase activity
HVW76_09855	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HVW76_09865	COG3139	Protein of unknown function (DUF1315)
HVW76_09870	COG1063	alcohol dehydrogenase
HVW76_09875	COG2271	Major facilitator Superfamily
HVW76_09880	COG1063	alcohol dehydrogenase
HVW76_09885	COG0191	fructose-bisphosphate aldolase activity
HVW76_09890	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HVW76_09895	COG0667	Aldo Keto reductase
HVW76_09900	COG1349	DNA-binding transcription factor activity
HVW76_09905	COG2814	Major facilitator Superfamily
HVW76_09910	COG1335	isochorismatase
HVW76_09915	COG0252	asparaginase activity
HVW76_09920	COG0616	signal peptide processing
HVW76_09925	COG0778	Nitroreductase
HVW76_09930	COG0709	Synthesizes selenophosphate from selenide and ATP
HVW76_09935	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HVW76_09945	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HVW76_09955	COG0494	nUDIX hydrolase
HVW76_09960	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HVW76_09965	COG2897	thiosulfate sulfurtransferase activity
HVW76_09970	COG4136	ATPase activity
HVW76_09975	COG4135	transport system, permease component
HVW76_09980	COG4134	Bacterial extracellular solute-binding protein
HVW76_09985	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HVW76_09990	COG0398	Pfam SNARE associated Golgi protein
HVW76_10000	COG0398	Pfam SNARE associated Golgi protein
HVW76_10005	COG0708	Exodeoxyribonuclease III
HVW76_10035	COG3678	ATP-independent chaperone mediated protein folding
HVW76_10045	COG0322	excinuclease ABC activity
HVW76_10055	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HVW76_10060	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HVW76_10065	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HVW76_10070	COG1447	Phosphotransferase system cellobiose-specific component IIA
HVW76_10075	COG2169	Transcriptional regulator
HVW76_10075	COG1917	Cupin 2, conserved barrel domain protein
HVW76_10080	COG1486	melibiose metabolic process
HVW76_10090	COG0753	catalase activity
HVW76_10110	COG1988	membrane-bound metal-dependent
HVW76_10115	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HVW76_10125	COG3001	Fructosamine kinase
HVW76_10135	COG1105	Belongs to the carbohydrate kinase PfkB family
HVW76_10140	COG3137	Salt-induced outer membrane protein
HVW76_10200	COG0386	Belongs to the glutathione peroxidase family
HVW76_10210	COG0791	NLP P60 protein
HVW76_10215	COG2200	EAL domain
HVW76_10225	COG4256	Hemin uptake protein
HVW76_10230	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HVW76_10240	COG0574	Belongs to the PEP-utilizing enzyme family
HVW76_10240	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HVW76_10245	COG0471	metal ion transport
HVW76_10250	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HVW76_10260	COG1028	Short-chain dehydrogenase reductase Sdr
HVW76_10265	COG0318	PFAM AMP-dependent synthetase and ligase
HVW76_10270	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
HVW76_10275	COG0644	oxidoreductase
HVW76_10280	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
HVW76_10285	COG2086	electron transfer activity
HVW76_10290	COG1917	Cupin 2, conserved barrel domain protein
HVW76_10290	COG2207	Transcriptional regulator
HVW76_10295	COG1960	acyl-CoA dehydrogenase activity
HVW76_10300	COG4670	ketone body catabolic process
HVW76_10315	COG2271	Major facilitator Superfamily
HVW76_10320	COG0738	Major facilitator superfamily
HVW76_10335	COG0628	permease
HVW76_10340	COG0247	lactate metabolic process
HVW76_10340	COG0277	FAD linked oxidase domain protein
HVW76_10345	COG2050	protein possibly involved in aromatic compounds catabolism
HVW76_10355	COG0316	Belongs to the HesB IscA family
HVW76_10360	COG0719	Fe-S assembly protein
HVW76_10365	COG0396	ATPase activity
HVW76_10370	COG0719	Fe-S assembly protein
HVW76_10385	COG1376	ErfK ybiS ycfS ynhG family protein
HVW76_10390	COG4238	major outer membrane lipoprotein
HVW76_10395	COG0469	pyruvate kinase activity
HVW76_10405	COG0437	4 iron, 4 sulfur cluster binding
HVW76_10410	COG2414	aldehyde ferredoxin oxidoreductase
HVW76_10420	COG0437	4 iron, 4 sulfur cluster binding
HVW76_10425	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
HVW76_10435	COG4529	Protein conserved in bacteria
HVW76_10455	COG3468	outer membrane autotransporter barrel domain protein
HVW76_10465	COG0307	riboflavin synthase, alpha
HVW76_10470	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HVW76_10475	COG2814	Major facilitator Superfamily
HVW76_10480	COG0583	DNA-binding transcription factor activity
HVW76_10495	COG2814	Major facilitator Superfamily
HVW76_10500	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HVW76_10505	COG0791	NLP P60 protein
HVW76_10510	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
HVW76_10515	COG1201	RNA secondary structure unwinding
HVW76_10525	COG0346	lactoylglutathione lyase activity
HVW76_10530	COG1902	pentaerythritol trinitrate reductase activity
HVW76_10535	COG1309	transcriptional regulator
HVW76_10540	COG3313	Fe-S protein
HVW76_10545	COG4989	oxidoreductase activity
HVW76_10550	COG2032	superoxide dismutase activity
HVW76_10555	COG1289	transmembrane transporter activity
HVW76_10560	COG1566	PFAM secretion protein HlyD family protein
HVW76_10575	COG3133	Outer membrane lipoprotein
HVW76_10585	COG3895	Periplasmic Protein
HVW76_10600	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
HVW76_10605	COG0625	glutathione transferase activity
HVW76_10610	COG3104	oligopeptide transport
HVW76_10615	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HVW76_10625	COG4659	FMN binding
HVW76_10665	COG0673	inositol 2-dehydrogenase activity
HVW76_10675	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HVW76_10680	COG1263	PTS System
HVW76_10680	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HVW76_10685	COG1609	Transcriptional regulator
HVW76_10690	COG1028	Short-chain dehydrogenase reductase Sdr
HVW76_10695	COG1309	transcriptional regulator
HVW76_10700	COG3250	beta-galactosidase activity
HVW76_10715	COG5339	Protein conserved in bacteria
HVW76_10720	COG1482	cell wall glycoprotein biosynthetic process
HVW76_10725	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HVW76_10725	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
HVW76_10730	COG0114	fumarate hydratase activity
HVW76_10740	COG2205	protein histidine kinase activity
HVW76_10745	COG0745	RESPONSE REGULATOR receiver
HVW76_10750	COG3136	membrane protein required for alginate biosynthesis
HVW76_10760	COG0531	amino acid
HVW76_10770	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
HVW76_10775	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
HVW76_10780	COG0628	permease
HVW76_10795	COG3591	Belongs to the peptidase S1B family
HVW76_10810	COG2814	Major facilitator Superfamily
HVW76_10815	COG0583	DNA-binding transcription factor activity
HVW76_10820	COG1940	carbohydrate kinase activity
HVW76_10825	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HVW76_10835	COG3381	protein complex oligomerization
HVW76_10840	COG3302	dmso reductase anchor subunit
HVW76_10845	COG0437	4 iron, 4 sulfur cluster binding
HVW76_10850	COG0243	molybdopterin cofactor binding
HVW76_10855	COG0243	molybdopterin cofactor binding
HVW76_10890	COG0243	molybdopterin cofactor binding
HVW76_10905	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HVW76_10920	COG4948	Mandelate Racemase Muconate Lactonizing
HVW76_10925	COG1063	alcohol dehydrogenase
HVW76_10935	COG0582	viral genome integration into host DNA
HVW76_10945	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HVW76_10980	COG2801	Transposase and inactivated derivatives
HVW76_10995	COG3077	Addiction module antitoxin, RelB DinJ family
HVW76_11000	COG2026	Addiction module toxin, RelE StbE family
HVW76_11020	COG1403	HNH endonuclease
HVW76_11025	COG0484	heat shock protein binding
HVW76_11035	COG1278	Cold shock
HVW76_11040	COG1278	Cold shock
HVW76_11055	COG3772	lysozyme
HVW76_11065	COG1278	Cold shock
HVW76_11090	COG5562	phage envelope protein
HVW76_11110	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
HVW76_11115	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HVW76_11135	COG0246	Mannitol dehydrogenase
HVW76_11145	COG1802	Transcriptional regulator
HVW76_11150	COG4221	oxidoreductase activity
HVW76_11155	COG0339	signal peptide processing
HVW76_11160	COG1546	Belongs to the CinA family
HVW76_11165	COG3111	PFAM Bacterial OB fold (BOF) protein
HVW76_11170	COG3706	GGDEF domain
HVW76_11180	COG2814	Major facilitator Superfamily
HVW76_11185	COG0697	spore germination
HVW76_11195	COG4977	sequence-specific DNA binding
HVW76_11200	COG1846	Transcriptional regulator
HVW76_11220	COG0583	DNA-binding transcription factor activity
HVW76_11225	COG1012	belongs to the aldehyde dehydrogenase family
HVW76_11230	COG2066	Belongs to the glutaminase family
HVW76_11240	COG2199	diguanylate cyclase activity
HVW76_11250	COG3781	membrane
HVW76_11310	COG3210	domain, Protein
HVW76_11310	COG2911	Protein conserved in bacteria
HVW76_11315	COG1396	sequence-specific DNA binding
HVW76_11320	COG3550	peptidyl-serine autophosphorylation
HVW76_11330	COG3539	Fimbrial protein
HVW76_11340	COG3188	usher protein
HVW76_11345	COG3539	Fimbrial protein
HVW76_11350	COG3539	Fimbrial protein
HVW76_11355	COG3539	Fimbrial protein
HVW76_11360	COG0243	molybdopterin cofactor binding
HVW76_11370	COG2207	Transcriptional regulator
HVW76_11375	COG3119	arylsulfatase activity
HVW76_11380	COG0641	radical SAM
HVW76_11390	COG4178	(ABC) transporter
HVW76_11395	COG4771	TonB-dependent receptor
HVW76_11400	COG0612	Peptidase, M16
HVW76_11405	COG0076	glutamate decarboxylase activity
HVW76_11410	COG0531	amino acid
HVW76_11425	COG3706	GGDEF domain
HVW76_11430	COG2202	Pas domain
HVW76_11430	COG2199	diguanylate cyclase activity
HVW76_11430	COG2200	EAL domain
HVW76_11435	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
HVW76_11440	COG0747	negative chemotaxis
HVW76_11445	COG0601	transmembrane transport
HVW76_11450	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HVW76_11455	COG0444	Belongs to the ABC transporter superfamily
HVW76_11460	COG4608	Belongs to the ABC transporter superfamily
HVW76_11465	COG1764	response to oxidative stress
HVW76_11485	COG1064	alcohol dehydrogenase
HVW76_11490	COG3093	addiction module antidote protein HigA
HVW76_11495	COG2864	formate dehydrogenase
HVW76_11500	COG0437	4 iron, 4 sulfur cluster binding
HVW76_11510	COG0697	spore germination
HVW76_11520	COG4886	Leucine-rich repeat (LRR) protein
HVW76_11525	COG4886	Leucine-rich repeat (LRR) protein
HVW76_11530	COG2223	nitrite transmembrane transporter activity
HVW76_11535	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
HVW76_11540	COG1140	nitrate reductase beta subunit
HVW76_11545	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
HVW76_11550	COG2181	nitrate reductase activity
HVW76_11555	COG0384	phenazine biosynthesis protein PhzF
HVW76_11560	COG2162	N-hydroxyarylamine O-acetyltransferase activity
HVW76_11565	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HVW76_11575	COG5433	transposase activity
HVW76_11605	COG0625	glutathione transferase activity
HVW76_11610	COG1113	amino acid transport
HVW76_11615	COG3391	amine dehydrogenase activity
HVW76_11620	COG4772	TonB-dependent receptor
HVW76_11625	COG1802	Transcriptional regulator
HVW76_11630	COG2130	NADP-dependent
HVW76_11635	COG1247	-acetyltransferase
HVW76_11640	COG3238	Protein conserved in bacteria
HVW76_11665	COG1177	transmembrane transport
HVW76_11670	COG1176	ABC-type spermidine putrescine transport system, permease component I
HVW76_11675	COG3842	ATPase activity
HVW76_11680	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HVW76_11685	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HVW76_11690	COG1598	PFAM Uncharacterised protein family UPF0150
HVW76_11695	COG1724	mRNA binding
HVW76_11705	COG0826	peptidase U32
HVW76_11710	COG1396	sequence-specific DNA binding
HVW76_11715	COG3135	benzoate transporter
HVW76_11735	COG0500	methyltransferase
HVW76_11740	COG1275	C4-dicarboxylate transporter malic acid transport protein
HVW76_11745	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HVW76_11750	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HVW76_11755	COG2841	Protein conserved in bacteria
HVW76_11765	COG5383	Protein conserved in bacteria
HVW76_11770	COG0583	DNA-binding transcription factor activity
HVW76_11775	COG0840	transmembrane signaling receptor activity
HVW76_11790	COG3038	cytochrome b561
HVW76_11795	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HVW76_11800	COG1012	belongs to the aldehyde dehydrogenase family
HVW76_11805	COG1434	Gram-negative-bacterium-type cell wall biogenesis
HVW76_11830	COG1643	Atp-dependent helicase
HVW76_11845	COG2267	carboxylic ester hydrolase activity
HVW76_11850	COG4589	Belongs to the CDS family
HVW76_11855	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HVW76_11865	COG0667	Aldo Keto reductase
HVW76_11880	COG3784	Protein of unknown function (DUF1318)
HVW76_11890	COG2911	Protein conserved in bacteria
HVW76_11895	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HVW76_11900	COG3187	Heat shock protein
HVW76_11905	COG3042	response to heat
HVW76_11910	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HVW76_11910	COG1013	pyruvate-flavodoxin oxidoreductase activity
HVW76_11910	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HVW76_11910	COG0674	pyruvate-flavodoxin oxidoreductase activity
HVW76_11920	COG0589	response to stress
HVW76_11930	COG0513	Belongs to the DEAD box helicase family
HVW76_11940	COG3706	GGDEF domain
HVW76_11945	COG2840	Smr protein MutS2
HVW76_11950	COG0583	DNA-binding transcription factor activity
HVW76_11955	COG1473	amidohydrolase
HVW76_11960	COG1473	amidohydrolase
HVW76_11965	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
HVW76_11970	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HVW76_11975	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HVW76_11980	COG0589	response to stress
HVW76_11985	COG3182	Iron-regulated membrane protein
HVW76_11990	COG0668	transmembrane transport
HVW76_11995	COG4166	transmembrane transport
HVW76_12000	COG0583	DNA-binding transcription factor activity
HVW76_12005	COG1073	alpha beta
HVW76_12010	COG1073	alpha beta
HVW76_12015	COG0702	epimerase
HVW76_12020	COG2866	Carboxypeptidase
HVW76_12025	COG4948	Mandelate Racemase Muconate Lactonizing
HVW76_12030	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
HVW76_12035	COG3283	Transcriptional regulator of aromatic amino acids metabolism
HVW76_12045	COG3106	COG3106 Predicted ATPase
HVW76_12050	COG1609	Transcriptional regulator
HVW76_12060	COG3842	ATPase activity
HVW76_12065	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HVW76_12070	COG1554	hydrolase, family 65, central catalytic
HVW76_12075	COG0673	inositol 2-dehydrogenase activity
HVW76_12080	COG1082	Xylose isomerase domain protein TIM barrel
HVW76_12085	COG1063	alcohol dehydrogenase
HVW76_12090	COG0395	ABC-type sugar transport system, permease component
HVW76_12095	COG1175	transmembrane transport
HVW76_12100	COG1653	transport
HVW76_12105	COG0366	Alpha amylase catalytic
HVW76_12110	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HVW76_12120	COG1983	PspC domain protein
HVW76_12130	COG1842	Phage shock protein A
HVW76_12135	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
HVW76_12140	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HVW76_12145	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HVW76_12150	COG1012	belongs to the aldehyde dehydrogenase family
HVW76_12155	COG1396	sequence-specific DNA binding
HVW76_12155	COG1917	Cupin 2, conserved barrel domain protein
HVW76_12160	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
HVW76_12165	COG0174	glutamine synthetase
HVW76_12175	COG0531	amino acid
HVW76_12185	COG4166	transmembrane transport
HVW76_12190	COG4168	peptide transport system, permease
HVW76_12195	COG4171	peptide transport system, permease
HVW76_12200	COG4172	Belongs to the ABC transporter superfamily
HVW76_12205	COG4172	Belongs to the ABC transporter superfamily
HVW76_12210	COG2814	Major facilitator Superfamily
HVW76_12220	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HVW76_12225	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HVW76_12235	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HVW76_12240	COG4950	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HVW76_12240	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HVW76_12255	COG5001	Diguanylate cyclase
HVW76_12265	COG1349	DNA-binding transcription factor activity
HVW76_12275	COG0023	Translation Initiation Factor
HVW76_12285	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
HVW76_12290	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
HVW76_12295	COG0671	phosphoesterase, PA-phosphatase related
HVW76_12305	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HVW76_12325	COG0583	DNA-binding transcription factor activity
HVW76_12330	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HVW76_12340	COG0616	signal peptide processing
HVW76_12345	COG1028	Short-chain dehydrogenase reductase Sdr
HVW76_12350	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
HVW76_12355	COG1187	pseudouridine synthase activity
HVW76_12360	COG4907	membrane protein (DUF2207)
HVW76_12365	COG0009	L-threonylcarbamoyladenylate synthase
HVW76_12370	COG0613	PHP domain protein
HVW76_12380	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HVW76_12385	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HVW76_12385	COG0512	Glutamine amidotransferase of anthranilate synthase
HVW76_12390	COG0135	phosphoribosylanthranilate isomerase activity
HVW76_12390	COG0134	indole-3-glycerol-phosphate synthase activity
HVW76_12405	COG3729	General stress protein
HVW76_12410	COG3685	Protein conserved in bacteria
HVW76_12415	COG3685	Protein conserved in bacteria
HVW76_12420	COG3047	cAMP biosynthetic process
HVW76_12440	COG1607	acyl-coa hydrolase
HVW76_12445	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
HVW76_12450	COG2350	Protein conserved in bacteria
HVW76_12455	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HVW76_12475	COG4608	Belongs to the ABC transporter superfamily
HVW76_12480	COG0444	Belongs to the ABC transporter superfamily
HVW76_12485	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HVW76_12490	COG0601	transmembrane transport
HVW76_12495	COG4166	transmembrane transport
HVW76_12500	COG2095	MarC family integral membrane protein
HVW76_12505	COG1012	belongs to the aldehyde dehydrogenase family
HVW76_12505	COG1454	alcohol dehydrogenase
HVW76_12510	COG1435	thymidine kinase activity
HVW76_12520	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HVW76_12525	COG0745	RESPONSE REGULATOR receiver
HVW76_12530	COG1752	Esterase of the alpha-beta hydrolase superfamily
HVW76_12540	COG0788	formyltetrahydrofolate deformylase activity
HVW76_12560	COG2181	nitrate reductase activity
HVW76_12565	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
HVW76_12570	COG1140	nitrate reductase beta subunit
HVW76_12575	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
HVW76_12580	COG2223	nitrite transmembrane transporter activity
HVW76_12585	COG3850	Histidine kinase
HVW76_12590	COG2197	response regulator
HVW76_12595	COG4932	domain protein
HVW76_12600	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
HVW76_12605	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
HVW76_12610	COG4572	Cation transport regulator
HVW76_12615	COG0387	Pfam Sodium calcium exchanger
HVW76_12635	COG2912	Transglutaminase-like superfamily
HVW76_12640	COG3094	Invasion gene expression up-regulator, SirB
HVW76_12645	COG2890	protein-(glutamine-N5) methyltransferase activity
HVW76_12670	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HVW76_12675	COG0659	secondary active sulfate transmembrane transporter activity
HVW76_12690	COG0012	GTP binding
HVW76_12695	COG3468	outer membrane autotransporter barrel domain protein
HVW76_12700	COG3284	Transcriptional regulator
HVW76_12705	COG2376	Dihydroxyacetone kinase
HVW76_12710	COG1461	Dihydroxyacetone kinase
HVW76_12715	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
HVW76_12715	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HVW76_12715	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HVW76_12735	COG1120	ATPase activity
HVW76_12740	COG0500	methyltransferase
HVW76_12745	COG0157	Belongs to the NadC ModD family
HVW76_12760	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
HVW76_12770	COG1619	proteins homologs of microcin C7 resistance protein MccF
HVW76_12790	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HVW76_12800	COG2719	SpoVR family
HVW76_12815	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
HVW76_12820	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HVW76_12825	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HVW76_12840	COG0179	Fumarylacetoacetate (FAA) hydrolase
HVW76_12865	COG2894	cell division
HVW76_12915	COG2200	EAL domain
HVW76_12940	COG2200	EAL domain
HVW76_12945	COG0789	Transcriptional regulator
HVW76_12950	COG5562	phage envelope protein
HVW76_12970	COG0538	isocitrate dehydrogenase activity
HVW76_12975	COG1187	pseudouridine synthase activity
HVW76_12995	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HVW76_13005	COG2205	protein histidine kinase activity
HVW76_13010	COG2850	peptidyl-arginine hydroxylation
HVW76_13020	COG3842	ATPase activity
HVW76_13030	COG1177	transmembrane transport
HVW76_13035	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HVW76_13040	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HVW76_13050	COG4591	ABC-type transport system involved in lipoprotein release permease component
HVW76_13055	COG1136	(ABC) transporter
HVW76_13060	COG4591	ABC-type transport system involved in lipoprotein release permease component
HVW76_13065	COG4763	Acyl-transferase
HVW76_13070	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HVW76_13075	COG1388	LysM domain
HVW76_13075	COG1376	ErfK ybiS ycfS ynhG family protein
HVW76_13085	COG1309	transcriptional regulator
HVW76_13090	COG3134	Outer membrane lipoprotein
HVW76_13095	COG1252	NADH dehydrogenase
HVW76_13115	COG3417	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)
HVW76_13120	COG5633	Lipoprotein
HVW76_13125	COG0537	adenosine 5'-monophosphoramidase activity
HVW76_13130	COG4773	Receptor
HVW76_13135	COG1263	PTS System
HVW76_13135	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HVW76_13140	COG0084	hydrolase, TatD family'
HVW76_13145	COG0470	DNA polymerase III
HVW76_13155	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HVW76_13160	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HVW76_13165	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HVW76_13175	COG1028	Short-chain dehydrogenase reductase Sdr
HVW76_13180	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HVW76_13200	COG1399	metal-binding, possibly nucleic acid-binding protein
HVW76_13205	COG0424	maF-like protein
HVW76_13210	COG0564	pseudouridine synthase activity
HVW76_13215	COG1530	ribonuclease E activity
HVW76_13220	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HVW76_13225	COG1256	bacterial-type flagellum assembly
HVW76_13230	COG3951	Flagellar rod assembly protein muramidase FlgJ
HVW76_13230	COG1705	Flagellar rod assembly protein muramidase FlgJ
HVW76_13245	COG4786	Flagellar basal body rod
HVW76_13250	COG4787	bacterial-type flagellum-dependent cell motility
HVW76_13255	COG1749	Flagellar hook protein flgE
HVW76_13260	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
HVW76_13265	COG1558	bacterial-type flagellum-dependent cell motility
HVW76_13270	COG1815	bacterial-type flagellum-dependent cell motility
HVW76_13275	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
HVW76_13280	COG2747	anti-sigma28 factor FlgM
HVW76_13285	COG3418	PFAM FlgN family protein
HVW76_13290	COG0728	peptidoglycan biosynthetic process
HVW76_13295	COG0673	inositol 2-dehydrogenase activity
HVW76_13305	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HVW76_13315	COG2999	glutathione oxidoreductase activity
HVW76_13350	COG3038	cytochrome b561
HVW76_13355	COG2353	YceI-like domain
HVW76_13365	COG1560	Kdo2-lipid A biosynthetic process
HVW76_13380	COG5645	(Lipo)protein
HVW76_13385	COG2943	transferase activity, transferring hexosyl groups
HVW76_13400	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HVW76_13405	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
HVW76_13430	COG2197	response regulator
HVW76_13445	COG1462	curli production assembly transport component CsgG
HVW76_13455	COG3381	protein complex oligomerization
HVW76_13520	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HVW76_13525	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HVW76_13535	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HVW76_13545	COG0736	holo-[acyl-carrier-protein] synthase activity
HVW76_13555	COG3210	domain, Protein
HVW76_13565	COG3539	Fimbrial protein
HVW76_13575	COG3188	usher protein
HVW76_13585	COG3121	Chaperone
HVW76_13590	COG1028	Short-chain dehydrogenase reductase Sdr
HVW76_13595	COG3710	Transcriptional regulator
HVW76_13605	COG2200	EAL domain
HVW76_13610	COG3706	GGDEF domain
HVW76_13615	COG0457	Tetratricopeptide repeat
HVW76_13620	COG1649	PFAM Uncharacterised BCR, COG1649
HVW76_13620	COG0726	polysaccharide deacetylase
HVW76_13625	COG1215	transferase activity, transferring glycosyl groups
HVW76_13630	COG3658	cytochrome
HVW76_13635	COG1702	phosphate starvation-inducible protein PhoH
HVW76_13660	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HVW76_13670	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HVW76_13670	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HVW76_13670	COG0506	proline dehydrogenase activity
HVW76_13675	COG1309	transcriptional regulator
HVW76_13710	COG2233	PERMEase
HVW76_13715	COG3729	General stress protein
HVW76_13755	COG0243	molybdopterin cofactor binding
HVW76_13760	COG3005	denitrification pathway
HVW76_13765	COG0745	RESPONSE REGULATOR receiver
HVW76_13770	COG1879	ABC-type sugar transport system periplasmic component
HVW76_13775	COG2205	protein histidine kinase activity
HVW76_13775	COG2198	Histidine kinase
HVW76_13775	COG0784	Response regulator, receiver
HVW76_13780	COG0348	domain, Protein
HVW76_13800	COG1278	Cold shock
HVW76_13805	COG1278	Cold shock
HVW76_13825	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HVW76_13830	COG1596	polysaccharide export
HVW76_13835	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HVW76_13840	COG0489	protein tyrosine kinase activity
HVW76_13840	COG3206	protein involved in exopolysaccharide biosynthesis
HVW76_13855	COG1294	oxidase, subunit
HVW76_13860	COG1271	oxidase subunit
HVW76_13865	COG1773	rubredoxin
HVW76_13870	COG1999	signal sequence binding
HVW76_13875	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
HVW76_13880	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
HVW76_13885	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
HVW76_13890	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
HVW76_13900	COG0670	Belongs to the BI1 family
HVW76_13905	COG2920	part of a sulfur-relay system
HVW76_13910	COG1254	Belongs to the acylphosphatase family
HVW76_13925	COG1832	CoA-binding protein
HVW76_13940	COG0210	DNA helicase
HVW76_13945	COG3304	Inner membrane component domain
HVW76_13950	COG1289	transmembrane transporter activity
HVW76_13955	COG3070	regulator of competence-specific genes
HVW76_13975	COG1067	ATP-dependent peptidase activity
HVW76_13985	COG3130	regulation of translation
HVW76_13990	COG3009	Protein conserved in bacteria
HVW76_13995	COG3008	intermembrane lipid transfer
HVW76_13995	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HVW76_14000	COG2995	paraquat-inducible protein a
HVW76_14005	COG0488	(ABC) transporter
HVW76_14015	COG0633	Ferredoxin
HVW76_14015	COG3217	Mosc domain protein beta barrel domain protein
HVW76_14030	COG3121	Chaperone
HVW76_14035	COG3539	Fimbrial protein
HVW76_14040	COG3539	Fimbrial protein
HVW76_14045	COG3539	Fimbrial protein
HVW76_14050	COG3188	usher protein
HVW76_14055	COG3121	Chaperone
HVW76_14060	COG3539	Fimbrial protein
HVW76_14065	COG0431	NADPH-dependent FMN reductase
HVW76_14070	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HVW76_14080	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HVW76_14085	COG1116	anion transmembrane transporter activity
HVW76_14090	COG0308	aminopeptidase N
HVW76_14105	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HVW76_14110	COG1448	Aminotransferase
HVW76_14115	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HVW76_14120	COG3108	Peptidase M15
HVW76_14125	COG2989	Protein conserved in bacteria
HVW76_14135	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
HVW76_14145	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HVW76_14150	COG1434	Gram-negative-bacterium-type cell wall biogenesis
HVW76_14155	COG3173	Aminoglycoside phosphotransferase
HVW76_14170	COG3214	Protein conserved in bacteria
HVW76_14180	COG1132	(ABC) transporter
HVW76_14185	COG0658	competence protein
HVW76_14185	COG2333	competence protein COMEC
HVW76_14195	COG0539	negative regulation of cytoplasmic translation
HVW76_14205	COG0501	Belongs to the peptidase M48B family
HVW76_14220	COG2323	membrane
HVW76_14225	COG1944	ATP diphosphatase activity
HVW76_14230	COG2116	formate transmembrane transporter activity
HVW76_14235	COG1882	Formate acetyltransferase
HVW76_14240	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HVW76_14250	COG0531	amino acid
HVW76_14260	COG1335	isochorismatase
HVW76_14265	COG3302	dmso reductase anchor subunit
HVW76_14270	COG0437	4 iron, 4 sulfur cluster binding
HVW76_14275	COG0243	molybdopterin cofactor binding
HVW76_14285	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HVW76_14300	COG1522	sequence-specific DNA binding
HVW76_14305	COG0492	ferredoxin-NADP+ reductase activity
HVW76_14310	COG4988	ABC transporter
HVW76_14315	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
HVW76_14335	COG0542	response to heat
HVW76_14380	COG1278	Cold shock
HVW76_14385	COG1136	(ABC) transporter
HVW76_14385	COG0577	efflux transmembrane transporter activity
HVW76_14390	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HVW76_14395	COG2990	Protein conserved in bacteria
HVW76_14400	COG3593	DNA synthesis involved in DNA repair
HVW76_14410	COG2431	L-lysine efflux transmembrane transporter activity
HVW76_14420	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HVW76_14425	COG0028	Belongs to the TPP enzyme family
HVW76_14430	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
HVW76_14435	COG0702	epimerase
HVW76_14440	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HVW76_14445	COG3023	N-Acetylmuramoyl-L-alanine amidase
HVW76_14465	COG1126	abc transporter atp-binding protein
HVW76_14470	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HVW76_14475	COG4215	(ABC) transporter
HVW76_14480	COG4160	amino acid transport
HVW76_14485	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HVW76_14495	COG3385	transposase activity
HVW76_14525	COG1177	transmembrane transport
HVW76_14530	COG1176	ABC-type spermidine putrescine transport system, permease component I
HVW76_14535	COG3842	ATPase activity
HVW76_14540	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HVW76_14555	COG0778	Nitroreductase
HVW76_14565	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HVW76_14585	COG3226	Transcriptional regulator
HVW76_14590	COG0738	Major facilitator superfamily
HVW76_14595	COG0561	phosphatase activity
HVW76_14605	COG2814	Major facilitator Superfamily
HVW76_14610	COG0671	phosphoesterase, PA-phosphatase related
HVW76_14615	COG1349	DNA-binding transcription factor activity
HVW76_14620	COG1686	Belongs to the peptidase S11 family
HVW76_14625	COG0625	glutathione transferase activity
HVW76_14630	COG2133	pyrroloquinoline quinone binding
HVW76_14655	COG2199	diguanylate cyclase activity
HVW76_14660	COG2200	EAL domain
HVW76_14675	COG0747	negative chemotaxis
HVW76_14685	COG1446	asparaginase
HVW76_14690	COG0303	'Molybdopterin
HVW76_14695	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HVW76_14700	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HVW76_14705	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HVW76_14710	COG1882	Formate acetyltransferase
HVW76_14715	COG0561	phosphatase activity
HVW76_14725	COG0488	(ABC) transporter
HVW76_14730	COG1376	ErfK ybiS ycfS ynhG family protein
HVW76_14735	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HVW76_14740	COG1321	iron dependent repressor
HVW76_14750	COG2194	sulfuric ester hydrolase activity
HVW76_14755	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
HVW76_14765	COG5006	permease, DMT superfamily
HVW76_14775	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HVW76_14780	COG0765	amino acid transport
HVW76_14785	COG1126	abc transporter atp-binding protein
HVW76_14790	COG0668	transmembrane transport
HVW76_14805	COG4774	siderophore transport
HVW76_14815	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HVW76_14825	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
HVW76_14830	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HVW76_14835	COG1199	ATP-dependent helicase activity
HVW76_14845	COG0513	Belongs to the DEAD box helicase family
HVW76_14850	COG1309	transcriptional regulator
HVW76_14860	COG1131	(ABC) transporter
HVW76_14865	COG0842	Transport permease protein
HVW76_14870	COG0842	Transport permease protein
HVW76_14880	COG3568	Endonuclease Exonuclease Phosphatase
HVW76_14885	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HVW76_14890	COG0392	lysyltransferase activity
HVW76_14895	COG0670	Belongs to the BI1 family
HVW76_14900	COG0670	Belongs to the BI1 family
HVW76_14905	COG0314	molybdopterin synthase activity
HVW76_14910	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
HVW76_14920	COG0521	Mo-molybdopterin cofactor biosynthetic process
HVW76_14930	COG0391	Required for morphogenesis under gluconeogenic growth conditions
HVW76_14940	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HVW76_14945	COG2226	methyltransferase
HVW76_14960	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HVW76_14965	COG1881	PFAM PEBP family protein
HVW76_14985	COG2207	Transcriptional regulator
HVW76_14995	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
HVW76_15000	COG5301	cellulose 1,4-beta-cellobiosidase activity
HVW76_15135	COG0582	viral genome integration into host DNA
HVW76_15140	COG4677	pectinesterase activity
HVW76_15145	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HVW76_15150	COG0471	metal ion transport
HVW76_15155	COG2828	Protein conserved in bacteria
HVW76_15160	COG0583	DNA-binding transcription factor activity
HVW76_15170	COG0561	phosphatase activity
HVW76_15180	COG4149	molybdate abc transporter
HVW76_15185	COG0725	ABC transporter, periplasmic molybdate-binding protein
HVW76_15195	COG2005	Transcriptional regulator
HVW76_15195	COG3585	molybdate ion transport
HVW76_15200	COG1119	ATPase activity
HVW76_15205	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HVW76_15210	COG1085	galactose-1-phosphate uridylyltransferase
HVW76_15220	COG2017	converts alpha-aldose to the beta-anomer
HVW76_15230	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HVW76_15240	COG1230	cation diffusion facilitator family transporter
HVW76_15245	COG3201	nicotinamide mononucleotide transporter
HVW76_15300	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
HVW76_15305	COG2885	chlorophyll binding
HVW76_15315	COG3064	Membrane
HVW76_15320	COG0848	biopolymer transport protein
HVW76_15325	COG0811	peptide transport
HVW76_15330	COG0824	Thioesterase
HVW76_15335	COG3790	cyd operon protein YbgE
HVW76_15340	COG4890	Cyd operon protein YbgT
HVW76_15345	COG1294	oxidase, subunit
HVW76_15350	COG1271	oxidase subunit
HVW76_15365	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HVW76_15375	COG4865	methylaspartate mutase activity
HVW76_15380	COG3799	methylaspartate ammonia-lyase activity
HVW76_15395	COG1301	dicarboxylic acid transport
HVW76_15400	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HVW76_15400	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
HVW76_15405	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
HVW76_15410	COG0583	DNA-binding transcription factor activity
HVW76_15415	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HVW76_15425	COG0508	dehydrogenase complex catalyzes the overall conversion of
HVW76_15430	COG0567	Dehydrogenase, E1 component
HVW76_15435	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HVW76_15440	COG1053	succinate dehydrogenase
HVW76_15445	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
HVW76_15450	COG2009	succinate dehydrogenase
HVW76_15460	COG0372	Belongs to the citrate synthase family
HVW76_15465	COG3539	Fimbrial protein
HVW76_15470	COG3188	usher protein
HVW76_15475	COG3121	Chaperone
HVW76_15480	COG3539	Fimbrial protein
HVW76_15485	COG3180	Ammonia monooxygenase
HVW76_15490	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HVW76_15500	COG1984	allophanate hydrolase subunit 2
HVW76_15505	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
HVW76_15510	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HVW76_15520	COG0415	Belongs to the DNA photolyase family
HVW76_15525	COG3272	Protein of unknown function (DUF1722)
HVW76_15555	COG2205	protein histidine kinase activity
HVW76_15560	COG0745	RESPONSE REGULATOR receiver
HVW76_15565	COG0033	Phosphoglucomutase
HVW76_15570	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
HVW76_15575	COG0596	Alpha beta hydrolase
HVW76_15585	COG0716	FMN binding
HVW76_15595	COG0735	belongs to the Fur family
HVW76_15615	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HVW76_15615	COG2190	(PTS) system
HVW76_15615	COG1263	PTS System
HVW76_15625	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HVW76_15630	COG1940	carbohydrate kinase activity
HVW76_15630	COG1846	Transcriptional regulator
HVW76_15635	COG0647	UMP catabolic process
HVW76_15640	COG0367	asparagine synthase
HVW76_15680	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HVW76_15690	COG1702	phosphate starvation-inducible protein PhoH
HVW76_15700	COG4535	Mg2 and Co2 transporter CorC
HVW76_15705	COG0815	Transfers the fatty acyl group on membrane lipoproteins
HVW76_15710	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HVW76_15715	COG0765	amino acid transport
HVW76_15720	COG0765	amino acid transport
HVW76_15725	COG1126	abc transporter atp-binding protein
HVW76_15735	COG0443	Heat shock 70 kDa protein
HVW76_15740	COG2214	Heat shock protein DnaJ domain protein
HVW76_15750	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
HVW76_15755	COG2214	Heat shock protein DnaJ domain protein
HVW76_15765	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
HVW76_15770	COG2888	peptidyl-tyrosine sulfation
HVW76_15785	COG1466	dna polymerase III delta subunit
HVW76_15795	COG0406	alpha-ribazole phosphatase activity
HVW76_15800	COG0799	negative regulation of ribosome biogenesis
HVW76_15810	COG0768	penicillin binding
HVW76_15815	COG0772	Belongs to the SEDS family
HVW76_15820	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HVW76_15825	COG1686	Belongs to the peptidase S11 family
HVW76_15840	COG0583	DNA-binding transcription factor activity
HVW76_15850	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HVW76_15855	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HVW76_15875	COG3069	C4-dicarboxylate transmembrane transporter activity
HVW76_15880	COG4565	transcriptional regulatory protein
HVW76_15885	COG3290	protein histidine kinase activity
HVW76_15890	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
HVW76_15900	COG2301	Belongs to the HpcH HpaI aldolase family
HVW76_15905	COG3051	citrate lyase alpha subunit
HVW76_15920	COG0471	metal ion transport
HVW76_15925	COG3719	Belongs to the RNase T2 family
HVW76_15930	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HVW76_15935	COG1063	alcohol dehydrogenase
HVW76_15940	COG0589	response to stress
HVW76_15945	COG3634	alkyl hydroperoxide reductase activity
HVW76_15950	COG0450	alkyl hydroperoxide reductase
HVW76_15955	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HVW76_15960	COG0583	DNA-binding transcription factor activity
HVW76_15965	COG3969	phosphoadenosine phosphosulfate
HVW76_15970	COG1475	DNA binding
HVW76_15975	COG0436	Aminotransferase
HVW76_15980	COG0371	Dehydrogenase
HVW76_15985	COG2879	small protein
HVW76_15990	COG1966	Carbon starvation protein
HVW76_15995	COG2050	protein possibly involved in aromatic compounds catabolism
HVW76_16000	COG1028	Short-chain dehydrogenase reductase Sdr
HVW76_16005	COG3433	isochorismatase activity
HVW76_16005	COG1535	isochorismatase
HVW76_16010	COG1021	2,3-dihydroxybenzoate-AMP ligase
HVW76_16015	COG1169	isochorismate synthase
HVW76_16020	COG4592	Periplasmic binding protein
HVW76_16030	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HVW76_16035	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HVW76_16040	COG1120	ATPase activity
HVW76_16045	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
HVW76_16050	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
HVW76_16050	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HVW76_16055	COG3251	PFAM MbtH domain protein
HVW76_16060	COG2382	esterase
HVW76_16065	COG4771	TonB-dependent receptor
HVW76_16070	COG2977	Belongs to the P-Pant transferase superfamily
HVW76_16075	COG3385	transposase activity
HVW76_16095	COG2315	Protein conserved in bacteria
HVW76_16100	COG0778	Nitroreductase
HVW76_16105	COG0668	transmembrane transport
HVW76_16110	COG1113	amino acid transport
HVW76_16115	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HVW76_16120	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HVW76_16125	COG5569	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HVW76_16130	COG1538	Outer membrane efflux protein
HVW76_16135	COG0745	RESPONSE REGULATOR receiver
HVW76_16140	COG5002	protein histidine kinase activity
HVW76_16155	COG3209	COG3209 Rhs family protein
HVW76_16155	COG4104	PAAR repeat-containing protein
HVW76_16165	COG4104	PAAR repeat-containing protein
HVW76_16165	COG3209	COG3209 Rhs family protein
HVW76_16185	COG5433	transposase activity
HVW76_16190	COG1215	transferase activity, transferring glycosyl groups
HVW76_16195	COG4783	chaperone-mediated protein folding
HVW76_16215	COG1475	DNA binding
HVW76_16220	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HVW76_16230	COG3772	lysozyme
HVW76_16275	COG2197	response regulator
HVW76_16280	COG3539	Fimbrial protein
HVW76_16285	COG3539	Fimbrial protein
HVW76_16290	COG3188	usher protein
HVW76_16295	COG3121	Chaperone
HVW76_16300	COG3539	Fimbrial protein
HVW76_16310	COG2501	S4 domain
HVW76_16315	COG1988	membrane-bound metal-dependent
HVW76_16325	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HVW76_16335	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HVW76_16340	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HVW76_16345	COG0549	Belongs to the carbamate kinase family
HVW76_16355	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HVW76_16360	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HVW76_16365	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
HVW76_16370	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HVW76_16375	COG3257	ureidoglycine aminohydrolase activity
HVW76_16380	COG1929	Belongs to the glycerate kinase type-1 family
HVW76_16385	COG2233	PERMEase
HVW76_16395	COG1953	Uracil, thiamine, allantoin
HVW76_16400	COG2084	Dehydrogenase
HVW76_16405	COG3622	Belongs to the hyi family
HVW76_16410	COG3960	tartronate-semialdehyde synthase activity
HVW76_16415	COG1414	Transcriptional regulator
HVW76_16425	COG0583	DNA-binding transcription factor activity
HVW76_16445	COG3209	COG3209 Rhs family protein
HVW76_16450	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
HVW76_16455	COG4181	ATPase activity
HVW76_16460	COG2755	lipolytic protein G-D-S-L family
HVW76_16465	COG0300	oxidoreductase activity
HVW76_16470	COG3118	belongs to the thioredoxin family
HVW76_16475	COG0390	transport system, permease component
HVW76_16480	COG4619	ABC transporter
HVW76_16485	COG0330	HflC and HflK could
HVW76_16490	COG1585	Membrane protein implicated in regulation of membrane protease activity
HVW76_16520	COG0789	Transcriptional regulator
HVW76_16545	COG0531	amino acid
HVW76_16555	COG2217	Heavy metal translocating P-type atpase
HVW76_16560	COG3093	addiction module antidote protein HigA
HVW76_16565	COG3735	TraB family
HVW76_16570	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HVW76_16575	COG0737	Belongs to the 5'-nucleotidase family
HVW76_16580	COG2223	nitrite transmembrane transporter activity
HVW76_16585	COG4651	solute:proton antiporter activity
HVW76_16585	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HVW76_16590	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HVW76_16625	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HVW76_16635	COG2832	Protein of unknown function (DUF454)
HVW76_16640	COG3923	Primosomal replication protein n
HVW76_16650	COG1196	nuclear chromosome segregation
HVW76_16650	COG3264	Mechanosensitive ion channel
HVW76_16655	COG1309	transcriptional regulator
HVW76_16660	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HVW76_16665	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HVW76_16680	COG0110	maltose O-acetyltransferase activity
HVW76_16690	COG4943	cyclic-guanylate-specific phosphodiesterase activity
HVW76_16695	COG5507	3-demethylubiquinone-9 3-methyltransferase
HVW76_16705	COG3695	enzyme binding
HVW76_16710	COG3126	Type III secretion system lipoprotein chaperone (YscW)
HVW76_16715	COG1946	Acyl-CoA thioesterase
HVW76_16720	COG0004	ammonium transporteR
HVW76_16725	COG0347	Belongs to the P(II) protein family
HVW76_16730	COG1132	(ABC) transporter
HVW76_16735	COG1132	(ABC) transporter
HVW76_16740	COG1522	sequence-specific DNA binding
HVW76_16750	COG4533	DNA binding
HVW76_16760	COG0824	Thioesterase
HVW76_16765	COG1555	photosystem II stabilization
HVW76_16770	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HVW76_16775	COG0776	regulation of translation
HVW76_16780	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HVW76_16800	COG0271	Belongs to the BolA IbaG family
HVW76_16805	COG3056	Lipoprotein
HVW76_16810	COG2223	nitrite transmembrane transporter activity
HVW76_16815	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HVW76_16820	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HVW76_16825	COG1845	cytochrome c oxidase, subunit III
HVW76_16830	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
HVW76_16840	COG2814	Major facilitator Superfamily
HVW76_16850	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HVW76_16855	COG0693	protein deglycase activity
HVW76_16870	COG0142	geranyltranstransferase activity
HVW76_16880	COG0667	Aldo Keto reductase
HVW76_16890	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HVW76_16895	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
HVW76_16910	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HVW76_16910	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HVW76_16920	COG4238	major outer membrane lipoprotein
HVW76_16925	COG3248	Nucleoside-binding outer membrane protein
HVW76_16930	COG1403	HNH endonuclease
HVW76_16935	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HVW76_16940	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HVW76_16945	COG1862	Preprotein translocase
HVW76_16970	COG0366	Alpha amylase catalytic
HVW76_16975	COG1113	amino acid transport
HVW76_16980	COG1114	Component of the transport system for branched-chain amino acids
HVW76_16985	COG5002	protein histidine kinase activity
HVW76_16990	COG0745	RESPONSE REGULATOR receiver
HVW76_16995	COG0420	3'-5' exonuclease activity
HVW76_17000	COG0419	ATPase involved in DNA repair
HVW76_17005	COG2814	Major facilitator Superfamily
HVW76_17010	COG1940	carbohydrate kinase activity
HVW76_17035	COG4126	flavin adenine dinucleotide binding
HVW76_17055	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HVW76_17060	COG3706	GGDEF domain
HVW76_17070	COG1785	Belongs to the alkaline phosphatase family
HVW76_17085	COG1181	Belongs to the D-alanine--D-alanine ligase family
HVW76_17105	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
HVW76_17110	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HVW76_17115	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HVW76_17120	COG3468	outer membrane autotransporter barrel domain protein
HVW76_17125	COG0113	porphobilinogen synthase activity
HVW76_17130	COG2175	clavaminate synthase activity
HVW76_17135	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HVW76_17145	COG4521	taurine ABC transporter
HVW76_17160	COG2271	Major facilitator Superfamily
HVW76_17165	COG1840	ABC-type Fe3 transport system, periplasmic component
HVW76_17175	COG3842	ATPase activity
HVW76_17190	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
HVW76_17195	COG3122	Protein conserved in bacteria
HVW76_17200	COG2814	Major facilitator Superfamily
HVW76_17205	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HVW76_17220	COG0596	Alpha beta hydrolase
HVW76_17235	COG1414	Transcriptional regulator
HVW76_17240	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HVW76_17250	COG1609	Transcriptional regulator
HVW76_17255	COG3250	beta-galactosidase activity
HVW76_17260	COG2223	nitrite transmembrane transporter activity
HVW76_17265	COG0110	maltose O-acetyltransferase activity
HVW76_17270	COG2807	transmembrane transport
HVW76_17280	COG0288	reversible hydration of carbon dioxide
HVW76_17285	COG0583	DNA-binding transcription factor activity
HVW76_17290	COG0402	S-adenosylhomocysteine deaminase activity
HVW76_17295	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HVW76_17300	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HVW76_17305	COG2079	MmgE PrpD family protein
HVW76_17310	COG0372	Belongs to the citrate synthase family
HVW76_17315	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
HVW76_17320	COG3829	transcription factor binding
HVW76_17330	COG1280	lysine exporter protein (LysE YggA)
HVW76_17345	COG1064	alcohol dehydrogenase
HVW76_17355	COG1172	Belongs to the binding-protein-dependent transport system permease family
HVW76_17360	COG1129	ABC transporter
HVW76_17365	COG1879	ABC-type sugar transport system periplasmic component
HVW76_17375	COG0402	S-adenosylhomocysteine deaminase activity
HVW76_17380	COG0549	Belongs to the carbamate kinase family
HVW76_17390	COG1304	FMN binding
HVW76_17395	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HVW76_17405	COG0666	response to abiotic stimulus
HVW76_17415	COG0583	DNA-binding transcription factor activity
HVW76_17420	COG2200	EAL domain
HVW76_17420	COG2771	luxR family
HVW76_17430	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HVW76_17460	COG2200	EAL domain
HVW76_17460	COG2771	luxR family
HVW76_17470	COG3468	outer membrane autotransporter barrel domain protein
HVW76_17480	COG1556	Lactate utilization protein
HVW76_17485	COG1139	Iron-sulfur cluster binding protein
HVW76_17490	COG0247	lactate metabolic process
HVW76_17495	COG2207	Transcriptional regulator
HVW76_17500	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HVW76_17510	COG3059	membrane
HVW76_17515	COG0656	L-ascorbic acid biosynthetic process
HVW76_17520	COG3708	Transcriptional regulator
HVW76_17520	COG2207	Transcriptional regulator
HVW76_17525	COG1388	LysM domain
HVW76_17530	COG0656	L-ascorbic acid biosynthetic process
HVW76_17535	COG0667	Aldo Keto reductase
HVW76_17545	COG0583	DNA-binding transcription factor activity
HVW76_17550	COG1073	alpha beta
HVW76_17555	COG1902	pentaerythritol trinitrate reductase activity
HVW76_17595	COG3188	usher protein
HVW76_17610	COG0727	PFAM Uncharacterised protein family (UPF0153)
HVW76_17615	COG3477	response to acidic pH
HVW76_17620	COG2080	2 iron, 2 sulfur cluster binding
HVW76_17625	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
HVW76_17635	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
HVW76_17650	COG0583	DNA-binding transcription factor activity
HVW76_17660	COG4221	oxidoreductase activity
HVW76_17665	COG0583	DNA-binding transcription factor activity
HVW76_17690	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HVW76_17765	COG5532	Uncharacterized conserved protein (DUF2303)
HVW76_17770	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
HVW76_17785	COG0582	viral genome integration into host DNA
HVW76_17805	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HVW76_17825	COG2195	Cleaves the N-terminal amino acid of tripeptides
HVW76_17830	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
HVW76_17835	COG1690	Belongs to the RtcB family
HVW76_17840	COG0454	-acetyltransferase
HVW76_17860	COG1943	Transposase
HVW76_17865	COG0791	NLP P60 protein
HVW76_17870	COG3077	Addiction module antitoxin, RelB DinJ family
HVW76_17875	COG3041	Addiction module toxin RelE StbE family
HVW76_17880	COG3034	peptidoglycan biosynthetic process
HVW76_17885	COG0121	glutamine amidotransferase
HVW76_17895	COG1960	acyl-CoA dehydrogenase activity
HVW76_17905	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HVW76_17955	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HVW76_17965	COG2226	methyltransferase
HVW76_17975	COG0741	lytic transglycosylase activity
HVW76_17975	COG1388	LysM domain
HVW76_17980	COG2226	methyltransferase
HVW76_17990	COG0583	DNA-binding transcription factor activity
HVW76_17995	COG0656	L-ascorbic acid biosynthetic process
HVW76_18030	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HVW76_18035	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HVW76_18040	COG2011	ABC-type metal ion transport system permease component
HVW76_18045	COG1464	Belongs to the NlpA lipoprotein family
HVW76_18055	COG1720	tRNA m6t6A37 methyltransferase activity
HVW76_18065	COG0791	NLP P60 protein
HVW76_18070	COG3015	lipoprotein NlpE involved in copper resistance
HVW76_18075	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
HVW76_18080	COG4681	YaeQ
HVW76_18090	COG4568	rho-dependent transcription termination
HVW76_18095	COG0037	tRNA processing
HVW76_18100	COG0346	lactoylglutathione lyase activity
HVW76_18115	COG0587	DNA-directed DNA polymerase activity
HVW76_18140	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HVW76_18145	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
HVW76_18155	COG0750	zinc metalloprotease
HVW76_18160	COG0575	Belongs to the CDS family
HVW76_18165	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HVW76_18170	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HVW76_18195	COG0024	Methionine aminopeptidase
HVW76_18215	COG3835	regulator
HVW76_18220	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HVW76_18235	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HVW76_18240	COG2860	membrane
HVW76_18265	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HVW76_18270	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HVW76_18275	COG1120	ATPase activity
HVW76_18280	COG4774	siderophore transport
HVW76_18285	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HVW76_18290	COG1643	Atp-dependent helicase
HVW76_18295	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
HVW76_18305	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HVW76_18310	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HVW76_18315	COG0617	tRNA 3'-terminal CCA addition
HVW76_18320	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HVW76_18330	COG3121	Chaperone
HVW76_18335	COG3188	usher protein
HVW76_18340	COG3539	Fimbrial protein
HVW76_18370	COG5464	transposase or invertase
HVW76_18380	COG0726	polysaccharide deacetylase
HVW76_18385	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HVW76_18390	COG0842	Transport permease protein
HVW76_18395	COG1131	(ABC) transporter
HVW76_18400	COG0288	reversible hydration of carbon dioxide
HVW76_18405	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
HVW76_18410	COG4993	Dehydrogenase
HVW76_18415	COG2132	Multicopper oxidase
HVW76_18440	COG1049	propionate catabolic process, 2-methylcitrate cycle
HVW76_18450	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HVW76_18455	COG0508	dehydrogenase complex catalyzes the overall conversion of
HVW76_18460	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
HVW76_18465	COG2186	Transcriptional regulator
HVW76_18475	COG3725	Membrane protein required for beta-lactamase induction
HVW76_18480	COG3023	N-Acetylmuramoyl-L-alanine amidase
HVW76_18485	COG0157	Belongs to the NadC ModD family
HVW76_18490	COG4969	Belongs to the N-Me-Phe pilin family
HVW76_18495	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HVW76_18500	COG1459	type II secretion system
HVW76_18515	COG0237	dephospho-CoA kinase activity
HVW76_18530	COG0494	nUDIX hydrolase
HVW76_18550	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HVW76_18555	COG0849	cell division
HVW76_18560	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
HVW76_18565	COG1181	Belongs to the D-alanine--D-alanine ligase family
HVW76_18580	COG0772	Belongs to the SEDS family
HVW76_18585	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HVW76_18595	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HVW76_18600	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HVW76_18605	COG0768	penicillin binding
HVW76_18610	COG3116	cell division
HVW76_18625	COG1609	Transcriptional regulator
HVW76_18635	COG0440	acetolactate synthase activity
HVW76_18640	COG0028	Belongs to the TPP enzyme family
HVW76_18645	COG0583	DNA-binding transcription factor activity
HVW76_18690	COG4143	(ABC) transporter
HVW76_18695	COG1178	ABC-type Fe3 transport system permease component
HVW76_18705	COG0586	Pfam SNARE associated Golgi protein
HVW76_18710	COG4977	sequence-specific DNA binding
HVW76_18725	COG0235	Class ii aldolase
HVW76_18730	COG0417	DNA replication proofreading
HVW76_18740	COG0564	pseudouridine synthase activity
HVW76_18750	COG1357	PFAM Pentapeptide repeats (8 copies)
HVW76_18755	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
HVW76_18760	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
HVW76_18765	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HVW76_18800	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HVW76_18815	COG2271	Major facilitator Superfamily
HVW76_18820	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
HVW76_18825	COG0644	oxidoreductase
HVW76_18875	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HVW76_18880	COG0505	Belongs to the CarA family
HVW76_18900	COG1047	Peptidyl-prolyl cis-trans
HVW76_18915	COG0196	riboflavin kinase activity
HVW76_18940	COG3121	Chaperone
HVW76_18945	COG3188	usher protein
HVW76_18955	COG0583	DNA-binding transcription factor activity
HVW76_18970	COG3385	transposase activity
HVW76_18990	COG4735	regulation of single-species biofilm formation
HVW76_18995	COG1584	GPR1 FUN34 yaaH family protein
HVW76_19000	COG0521	Mo-molybdopterin cofactor biosynthetic process
HVW76_19005	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HVW76_19010	COG1115	amino acid carrier protein
HVW76_19025	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HVW76_19035	COG0527	aspartate kinase activity
HVW76_19035	COG0460	homoserine dehydrogenase
HVW76_19045	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
HVW76_19055	COG0745	RESPONSE REGULATOR receiver
HVW76_19060	COG4452	Inner membrane protein CreD
HVW76_19065	COG2205	protein histidine kinase activity
HVW76_19070	COG0745	RESPONSE REGULATOR receiver
HVW76_19075	COG3045	CreA protein
HVW76_19080	COG2207	Transcriptional regulator
HVW76_19080	COG3708	Transcriptional regulator
HVW76_19100	COG0741	lytic transglycosylase activity
HVW76_19105	COG0488	(ABC) transporter
HVW76_19115	COG3172	ATPase kinase involved in NAD metabolism
HVW76_19115	COG1056	cytidyltransferase-related domain
HVW76_19120	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HVW76_19125	COG0560	Phosphoserine phosphatase
HVW76_19130	COG3726	membrane protein affecting hemolysin expression
HVW76_19165	COG1328	CTP reductase activity
HVW76_19170	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HVW76_19175	COG0084	hydrolase, TatD family'
HVW76_19180	COG4667	esterase of the alpha-beta hydrolase superfamily
HVW76_19190	COG2823	Periplasmic or secreted lipoprotein
HVW76_19200	COG1011	Hydrolase
HVW76_19205	COG0456	acetyltransferase
HVW76_19210	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
HVW76_19240	COG4114	ferric iron reductase
HVW76_19245	COG2197	response regulator
HVW76_19250	COG2197	response regulator
HVW76_19255	COG2966	Psort location CytoplasmicMembrane, score
HVW76_19270	COG1484	DNA-dependent DNA replication
HVW76_19285	COG1063	alcohol dehydrogenase
HVW76_19295	COG2271	Major facilitator Superfamily
HVW76_19300	COG0840	transmembrane signaling receptor activity
HVW76_19310	COG1966	Carbon starvation protein
HVW76_19315	COG2879	small protein
HVW76_19320	COG0523	cobalamin synthesis protein
HVW76_19335	COG1715	Restriction endonuclease
HVW76_19340	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
HVW76_19345	COG0732	type I restriction modification DNA specificity domain
HVW76_19350	COG0610	Subunit R is required for both nuclease and ATPase activities, but not for modification
HVW76_19360	COG5457	Domain of unknown function (DUF1127)
HVW76_19365	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HVW76_19375	COG2814	Major facilitator Superfamily
HVW76_19380	COG2733	membrane
HVW76_19385	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
HVW76_19390	COG1924	4 iron, 4 sulfur cluster binding
HVW76_19405	COG3204	pilus organization
HVW76_19410	COG0477	Major facilitator Superfamily
HVW76_19415	COG1388	LysM domain
HVW76_19415	COG1470	cell adhesion involved in biofilm formation
HVW76_19425	COG3366	ferrous iron transmembrane transporter activity
HVW76_19430	COG0700	Nucleoside recognition
HVW76_19435	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HVW76_19440	COG0583	DNA-binding transcription factor activity
HVW76_19460	COG2186	Transcriptional regulator
HVW76_19465	COG0246	Mannitol dehydrogenase
HVW76_19475	COG2610	gluconate transmembrane transporter activity
HVW76_19480	COG3539	Fimbrial protein
HVW76_19485	COG3539	Fimbrial protein
HVW76_19490	COG3539	Fimbrial protein
HVW76_19495	COG3188	usher protein
HVW76_19500	COG3121	Chaperone
HVW76_19505	COG3539	Fimbrial protein
HVW76_19510	COG3539	Fimbrial protein
HVW76_19515	COG4974	Belongs to the 'phage' integrase family
HVW76_19520	COG0582	viral genome integration into host DNA
HVW76_19525	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
HVW76_19545	COG0210	DNA helicase
HVW76_19550	COG1111	helicase
HVW76_19550	COG1205	dead DEAH box helicase
HVW76_19560	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HVW76_19615	COG1064	alcohol dehydrogenase
HVW76_19620	COG3265	gluconokinase activity
HVW76_19625	COG1063	alcohol dehydrogenase
HVW76_19630	COG1028	Short-chain dehydrogenase reductase Sdr
HVW76_19635	COG2610	gluconate transmembrane transporter activity
HVW76_19640	COG1609	Transcriptional regulator
HVW76_19645	COG0433	COG0433 Predicted ATPase
HVW76_19650	COG0795	lipopolysaccharide-transporting ATPase activity
HVW76_19655	COG0795	lipopolysaccharide-transporting ATPase activity
HVW76_19665	COG2927	DNA polymerase III (CHI subunit)
HVW76_19675	COG4269	membrane
HVW76_19680	COG0456	acetyltransferase
HVW76_19685	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
HVW76_19700	COG2731	YhcH YjgK YiaL family protein
HVW76_19705	COG1309	transcriptional regulator
HVW76_19710	COG1028	Short-chain dehydrogenase reductase Sdr
HVW76_19715	COG0251	oxidation-reduction process
HVW76_19735	COG0251	oxidation-reduction process
HVW76_19740	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HVW76_19750	COG1609	Transcriptional regulator
HVW76_19755	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HVW76_19755	COG1263	PTS System
HVW76_19760	COG0366	Alpha amylase catalytic
HVW76_19765	COG1328	CTP reductase activity
HVW76_19770	COG0602	queuosine metabolic process
HVW76_19775	COG3783	Cytochrome b(562)
HVW76_19780	COG0312	modulator of DNA gyrase
HVW76_19790	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HVW76_19800	COG1172	Belongs to the binding-protein-dependent transport system permease family
HVW76_19805	COG1172	Belongs to the binding-protein-dependent transport system permease family
HVW76_19810	COG1129	ABC transporter
HVW76_19815	COG1879	ABC-type sugar transport system periplasmic component
HVW76_19820	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HVW76_19825	COG2337	Toxic component of a toxin-antitoxin (TA) module
HVW76_19830	COG2336	PFAM SpoVT AbrB
HVW76_19835	COG2105	PFAM AIG2 family protein
HVW76_19840	COG2911	Protein conserved in bacteria
HVW76_19845	COG0729	surface antigen
HVW76_19855	COG1253	flavin adenine dinucleotide binding
HVW76_19865	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
HVW76_19875	COG1218	3'(2'),5'-bisphosphate nucleotidase
HVW76_19880	COG0737	Belongs to the 5'-nucleotidase family
HVW76_19885	COG1733	regulation of RNA biosynthetic process
HVW76_19890	COG0702	epimerase
HVW76_19895	COG0697	spore germination
HVW76_19905	COG1113	amino acid transport
HVW76_19910	COG0545	Peptidyl-prolyl cis-trans isomerase
HVW76_19915	COG3061	Opacity-associated protein A
HVW76_19925	COG0675	Transposase, IS605 OrfB family
HVW76_19950	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HVW76_19990	COG3414	Phosphotransferase system galactitol-specific IIB component
HVW76_19995	COG3037	sugar-specific permease SgaT UlaA
HVW76_20010	COG1073	alpha beta
HVW76_20015	COG3650	response to hydrogen peroxide
HVW76_20025	COG1960	acyl-CoA dehydrogenase activity
HVW76_20030	COG0754	glutathionylspermidine amidase activity
HVW76_20035	COG5463	Belongs to the UPF0441 family
HVW76_20040	COG3766	membrane
HVW76_20050	COG1842	Phage shock protein A
HVW76_20055	COG3789	protein conserved in bacteria
HVW76_20060	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HVW76_20065	COG0557	exoribonuclease II activity
HVW76_20080	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
HVW76_20085	COG0330	HflC and HflK could
HVW76_20090	COG0330	HflC and HflK could
HVW76_20095	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HVW76_20115	COG0860	N-Acetylmuramoyl-L-alanine amidase
HVW76_20120	COG0802	atpase or kinase
HVW76_20125	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HVW76_20125	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HVW76_20170	COG3264	Mechanosensitive ion channel
HVW76_20170	COG1511	domain protein
HVW76_20175	COG0531	amino acid
HVW76_20185	COG1053	succinate dehydrogenase
HVW76_20190	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HVW76_20205	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HVW76_20210	COG3040	lipid binding
HVW76_20215	COG2076	Multidrug Resistance protein
HVW76_20220	COG5510	response to toxic substance
HVW76_20225	COG5510	response to toxic substance
HVW76_20235	COG1509	lysine 2,3-aminomutase activity
HVW76_20260	COG0531	amino acid
HVW76_20265	COG3030	protein affecting phage T7 exclusion by the F plasmid
HVW76_20270	COG1027	Aspartate ammonia-lyase
HVW76_20275	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HVW76_20290	COG1309	transcriptional regulator
HVW76_20300	COG3710	Transcriptional regulator
HVW76_20305	COG0531	amino acid
HVW76_20310	COG1982	Orn Lys Arg decarboxylase major
HVW76_20315	COG3104	oligopeptide transport
HVW76_20320	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HVW76_20335	COG2388	GCN5-related N-acetyl-transferase
HVW76_20340	COG3592	Divergent 4Fe-4S mono-cluster
HVW76_20345	COG3290	protein histidine kinase activity
HVW76_20350	COG4565	transcriptional regulatory protein
HVW76_20355	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HVW76_20360	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
HVW76_20360	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HVW76_20365	COG3647	Membrane
HVW76_20370	COG2211	Major facilitator Superfamily
HVW76_20375	COG1486	melibiose metabolic process
HVW76_20380	COG2169	Transcriptional regulator
HVW76_20385	COG1982	Orn Lys Arg decarboxylase major
HVW76_20390	COG2207	Transcriptional regulator
HVW76_20395	COG0531	amino acid
HVW76_20400	COG2194	sulfuric ester hydrolase activity
HVW76_20405	COG0745	RESPONSE REGULATOR receiver
HVW76_20410	COG0642	Histidine kinase
HVW76_20420	COG0477	Major facilitator Superfamily
HVW76_20430	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
HVW76_20435	COG2824	Alkylphosphonate utilization operon protein PhnA
HVW76_20440	COG2764	glyoxalase bleomycin resistance protein dioxygenase
HVW76_20450	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
HVW76_20455	COG3639	organic phosphonate transmembrane transporter activity
HVW76_20460	COG2188	Transcriptional regulator
HVW76_20465	COG3624	Phosphonate C-P lyase system protein PhnG
HVW76_20470	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
HVW76_20475	COG3626	phosphonate metabolism
HVW76_20480	COG3627	carbon phosphorus lyase activity
HVW76_20485	COG4107	phosphonate C-P lyase system protein PhnK
HVW76_20490	COG4778	phosphonate C-P lyase system protein PhnL
HVW76_20495	COG3454	Phosphonate metabolism
HVW76_20500	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
HVW76_20505	COG0456	acetyltransferase
HVW76_20510	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
HVW76_20520	COG0698	ribose 5-phosphate isomerase
HVW76_20525	COG2015	COG2015, Alkyl sulfatase and related hydrolases
HVW76_20535	COG1566	PFAM secretion protein HlyD family protein
HVW76_20540	COG1289	transmembrane transporter activity
HVW76_20555	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
HVW76_20560	COG1301	dicarboxylic acid transport
HVW76_20565	COG4235	cytochrome complex assembly
HVW76_20570	COG3088	subunit of a heme lyase
HVW76_20575	COG1138	Cytochrome C-type biogenesis protein
HVW76_20580	COG3301	Polysulphide reductase, NrfD
HVW76_20585	COG0437	4 iron, 4 sulfur cluster binding
HVW76_20590	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
HVW76_20600	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HVW76_20605	COG3162	membrane
HVW76_20615	COG1357	PFAM Pentapeptide repeats (8 copies)
HVW76_20620	COG0025	NhaP-type Na H and K H
HVW76_20625	COG2252	PERMEase
HVW76_20630	COG0789	Transcriptional regulator
HVW76_20635	COG2207	Transcriptional regulator
HVW76_20640	COG4943	cyclic-guanylate-specific phosphodiesterase activity
HVW76_20650	COG0629	single-stranded DNA binding
HVW76_20655	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HVW76_20660	COG2315	Protein conserved in bacteria
HVW76_20665	COG0432	Pfam Uncharacterised protein family UPF0047
HVW76_20670	COG3700	Belongs to the class B bacterial acid phosphatase family
HVW76_20680	COG1448	Aminotransferase
HVW76_20685	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HVW76_20690	COG0305	Participates in initiation and elongation during chromosome replication
HVW76_20695	COG0604	alcohol dehydrogenase
HVW76_20705	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HVW76_20715	COG0735	belongs to the Fur family
HVW76_20720	COG3237	CsbD-like
HVW76_20725	COG0534	Mate efflux family protein
HVW76_20735	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HVW76_20755	COG1357	PFAM Pentapeptide repeats (8 copies)
HVW76_20770	COG3842	ATPase activity
HVW76_20775	COG2182	Extracellular solute-binding protein
HVW76_20780	COG1175	transmembrane transport
HVW76_20785	COG3833	ABC-type maltose transport systems, permease component
HVW76_20790	COG0477	Major facilitator Superfamily
HVW76_20790	COG2814	Major facilitator Superfamily
HVW76_20810	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HVW76_20835	COG0527	aspartate kinase activity
HVW76_20845	COG1187	pseudouridine synthase activity
HVW76_20890	COG1283	sodium-dependent phosphate transmembrane transporter activity
HVW76_20895	COG1410	methionine synthase
HVW76_20895	COG0646	methionine synthase
HVW76_20900	COG1414	Transcriptional regulator
HVW76_20915	COG2224	Isocitrate lyase
HVW76_20920	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
HVW76_20930	COG0456	acetyltransferase
HVW76_20960	COG0151	Belongs to the GarS family
HVW76_20965	COG2204	response regulator
HVW76_20970	COG4191	Histidine kinase
HVW76_20975	COG3678	ATP-independent chaperone mediated protein folding
HVW76_20990	COG3068	Protein conserved in bacteria
HVW76_21025	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HVW76_21030	COG2104	thiamine diphosphate biosynthetic process
HVW76_21040	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HVW76_21080	COG0250	Participates in transcription elongation, termination and antitermination
HVW76_21085	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HVW76_21120	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
HVW76_21120	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
HVW76_21150	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HVW76_21155	COG4206	TonB-dependent receptor
HVW76_21160	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HVW76_21170	COG1309	transcriptional regulator
HVW76_21175	COG0477	Major facilitator Superfamily
HVW76_21180	COG1473	amidohydrolase
HVW76_21190	COG0583	DNA-binding transcription factor activity
HVW76_21205	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HVW76_21220	COG2194	sulfuric ester hydrolase activity
HVW76_21225	COG2207	Transcriptional regulator
HVW76_21230	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HVW76_21235	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HVW76_21240	COG1882	Formate acetyltransferase
HVW76_21245	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HVW76_21250	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HVW76_21255	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HVW76_21255	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HVW76_21255	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HVW76_21260	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HVW76_21265	COG0371	Dehydrogenase
HVW76_21270	COG3738	Protein conserved in bacteria
HVW76_21275	COG0697	spore germination
HVW76_21285	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HVW76_21295	COG0527	aspartate kinase activity
HVW76_21295	COG0460	homoserine dehydrogenase
HVW76_21300	COG0626	cystathionine gamma-synthase activity
HVW76_21310	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
HVW76_21320	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HVW76_21325	COG1609	Transcriptional regulator
HVW76_21330	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HVW76_21345	COG1575	Belongs to the MenA family. Type 1 subfamily
HVW76_21370	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HVW76_21380	COG1494	fructose-1,6-bisphosphatase
HVW76_21390	COG0589	response to stress
HVW76_21395	COG3691	Protein conserved in bacteria
HVW76_21400	COG3152	Membrane
HVW76_21420	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
HVW76_21435	COG3678	ATP-independent chaperone mediated protein folding
HVW76_21440	COG0745	RESPONSE REGULATOR receiver
HVW76_21445	COG2205	protein histidine kinase activity
HVW76_21450	COG2258	MOSC domain
HVW76_21460	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HVW76_21470	COG4977	sequence-specific DNA binding
HVW76_21470	COG1917	Cupin 2, conserved barrel domain protein
HVW76_21505	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HVW76_21510	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HVW76_21510	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HVW76_21515	COG1363	Peptidase, m42
HVW76_21520	COG3711	transcriptional antiterminator
HVW76_21520	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HVW76_21540	COG0437	4 iron, 4 sulfur cluster binding
HVW76_21545	COG2864	formate dehydrogenase
HVW76_21555	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HVW76_21560	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HVW76_21570	COG0456	acetyltransferase
HVW76_21585	COG1011	Hydrolase
HVW76_21590	COG1349	DNA-binding transcription factor activity
HVW76_21595	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HVW76_21600	COG2084	Dehydrogenase
HVW76_21605	COG3684	Belongs to the aldolase LacD family
HVW76_21610	COG2942	2-epimerase
HVW76_21615	COG2017	converts alpha-aldose to the beta-anomer
HVW76_21625	COG1501	Belongs to the glycosyl hydrolase 31 family
HVW76_21630	COG2211	Major facilitator Superfamily
HVW76_21635	COG2211	Major facilitator Superfamily
HVW76_21640	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
HVW76_21645	COG2271	Major facilitator Superfamily
HVW76_21650	COG1082	Xylose isomerase domain protein TIM barrel
HVW76_21655	COG2188	Transcriptional regulator
HVW76_21665	COG0174	glutamine synthetase
HVW76_21670	COG3852	Histidine kinase
HVW76_21675	COG2204	response regulator
HVW76_21685	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HVW76_21690	COG3078	GTPase activator activity
HVW76_21700	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HVW76_21700	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HVW76_21705	COG0204	Acyl-transferase
HVW76_21710	COG5339	Protein conserved in bacteria
HVW76_21715	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HVW76_21720	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HVW76_21725	COG3084	Protein conserved in bacteria
HVW76_21730	COG0746	molybdenum cofactor guanylyltransferase activity
HVW76_21735	COG1763	Mo-molybdopterin cofactor biosynthetic process
HVW76_21760	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
HVW76_21765	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HVW76_21770	COG1739	Uncharacterized protein family UPF0029
HVW76_21785	COG0183	Belongs to the thiolase family
HVW76_21790	COG0543	2 iron, 2 sulfur cluster binding
HVW76_21795	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HVW76_21800	COG0250	Participates in transcription elongation, termination and antitermination
HVW76_21805	COG0084	hydrolase, TatD family'
HVW76_21810	COG0805	protein transport
HVW76_21815	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HVW76_21820	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HVW76_21830	COG3165	ubiquinone biosynthetic process from chorismate
HVW76_21840	COG1322	Protein conserved in bacteria
HVW76_21845	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
HVW76_21850	COG0412	Dienelactone hydrolase
HVW76_21860	COG0583	DNA-binding transcription factor activity
HVW76_21865	COG0697	spore germination
HVW76_21870	COG0561	phosphatase activity
HVW76_21875	COG2267	carboxylic ester hydrolase activity
HVW76_21880	COG1280	lysine exporter protein (LysE YggA)
HVW76_21885	COG1280	lysine exporter protein (LysE YggA)
HVW76_21890	COG0514	ATP-dependent DNA helicase (RecQ)
HVW76_21895	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
HVW76_21900	COG2050	protein possibly involved in aromatic compounds catabolism
HVW76_21905	COG2962	Rard protein
HVW76_21920	COG0598	Magnesium transport protein CorA
HVW76_21925	COG3698	Phosphodiester glycosidase
HVW76_21930	COG0210	DNA helicase
HVW76_21935	COG1011	Hydrolase
HVW76_21945	COG3159	Protein conserved in bacteria
HVW76_21955	COG5567	small periplasmic lipoprotein
HVW76_21975	COG3072	Adenylate cyclase
HVW76_21985	COG1587	Uroporphyrinogen-III synthase
HVW76_21990	COG2959	enzyme of heme biosynthesis
HVW76_21995	COG3071	HemY protein
HVW76_22000	COG3119	arylsulfatase activity
HVW76_22005	COG0641	radical SAM
HVW76_22030	COG1113	amino acid transport
HVW76_22050	COG2244	polysaccharide biosynthetic process
HVW76_22055	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HVW76_22060	COG0456	acetyltransferase
HVW76_22065	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
HVW76_22070	COG1088	dTDP-glucose 4,6-dehydratase activity
HVW76_22075	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
HVW76_22080	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HVW76_22085	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
HVW76_22090	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HVW76_22095	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
HVW76_22105	COG3118	belongs to the thioredoxin family
HVW76_22120	COG0210	DNA helicase
HVW76_22125	COG3692	DNA binding
HVW76_22130	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HVW76_22140	COG0583	DNA-binding transcription factor activity
HVW76_22145	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HVW76_22155	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HVW76_22160	COG3978	acetolactate synthase activity
HVW76_22180	COG0606	chelatase, subunit chli
HVW76_22185	COG3085	chromosome segregation
HVW76_22230	COG2186	Transcriptional regulator
HVW76_22235	COG0477	Major facilitator Superfamily
HVW76_22240	COG1609	Transcriptional regulator
HVW76_22245	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HVW76_22250	COG1879	ABC-type sugar transport system periplasmic component
HVW76_22255	COG1172	Belongs to the binding-protein-dependent transport system permease family
HVW76_22260	COG1129	ABC transporter
HVW76_22290	COG1522	sequence-specific DNA binding
HVW76_22295	COG0716	FMN binding
HVW76_22310	COG3312	ion transport
HVW76_22360	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HVW76_22385	COG3539	Fimbrial protein
HVW76_22395	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HVW76_22400	COG0573	inorganic phosphate transmembrane transporter activity
HVW76_22405	COG0581	inorganic phosphate transmembrane transporter activity
HVW76_22410	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HVW76_22415	COG0704	Plays a role in the regulation of phosphate uptake
HVW76_22440	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HVW76_22445	COG2252	PERMEase
HVW76_22450	COG0431	NADPH-dependent FMN reductase
HVW76_22455	COG2091	lysine biosynthetic process via aminoadipic acid
HVW76_22470	COG0814	amino acid
HVW76_22630	COG1196	nuclear chromosome segregation
HVW76_22820	COG1309	transcriptional regulator
HVW76_22830	COG3173	Aminoglycoside phosphotransferase
HVW76_22850	COG5001	Diguanylate cyclase
HVW76_22850	COG3300	MHYT domain
HVW76_22890	COG3385	transposase activity
HVW76_22910	COG0697	spore germination