locus-tag class description HVX61_00025 ENOG4105ED4 portal protein HVX61_00115 ENOG4108X9F tail fiber protein HVX61_00115 ENOG4108X9F tail fiber protein HVX61_00120 ENOG4105UZW Tail fiber assembly protein HVX61_00175 ENOG4105ZTC transcriptional activator, Ogr delta HVX61_00190 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein HVX61_00205 ENOG4105EBK exported protein HVX61_00210 ENOG4108VTS Membrane HVX61_00215 ENOG41065TG regulatoR HVX61_00225 ENOG4105DP0 ferredoxin-NADP reductase HVX61_00230 ENOG4105CBT Fructose-1,6-bisphosphatase HVX61_00240 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) HVX61_00265 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase HVX61_00280 ENOG41063M6 Cell Division Protein HVX61_00285 ENOG4105ETE Transcriptional regulator (LacI family HVX61_00290 ENOG4105C25 Primosomal protein n' HVX61_00300 ENOG4107S01 Repressor protein MetJ HVX61_00310 ENOG4105C28 cystathionine HVX61_00315 ENOG4105CFH Aspartokinase HVX61_00320 ENOG4105SYT Methylenetetrahydrofolate reductase HVX61_00330 ENOG4108Q5Y Membrane HVX61_00335 ENOG4108XC3 NADH ubiquinone oxidoreductase HVX61_00340 ENOG4105DCT glycerol dehydrogenase HVX61_00345 ENOG4107T9Z Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) HVX61_00350 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) HVX61_00355 ENOG4105DM4 PTS System HVX61_00360 ENOG4108YRF PTS System HVX61_00370 ENOG4108AHH pyruvate formate lyase II activase HVX61_00375 ENOG4108XCZ PTS System HVX61_00380 ENOG4106R3P AraC family transcriptional regulator HVX61_00385 ENOG4105DIJ Phosphoethanolamine transferase HVX61_00400 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase HVX61_00415 ENOG4105C5Q Transcriptional regulator HVX61_00425 ENOG4105CH2 amidohydrolase HVX61_00435 ENOG4105EJ2 Transcriptional regulator HVX61_00440 ENOG4108Y73 Membrane HVX61_00445 ENOG4107R9T Catalyzes the formation of 5-methyl-uridine at position 54 (m5U54) in all tRNAs (By similarity) HVX61_00450 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) HVX61_00455 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) HVX61_00485 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase HVX61_00520 ENOG4105PM1 preprotein translocase subunit SecE HVX61_00525 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) HVX61_00560 ENOG410645W Thiamin biosynthesis protein ThiH HVX61_00565 ENOG4105D41 biosynthesis protein thiH HVX61_00570 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) HVX61_00575 ENOG4105WHD thiamine biosynthesis protein ThiS HVX61_00580 ENOG4105D06 uba thif-type nad fad binding protein HVX61_00615 ENOG4105R2J Conserved Protein HVX61_00625 ENOG4108T8B Protein of unknown function (DUF1481) HVX61_00630 ENOG4105JBU Binds zinc. Could be an important component of the zinc- balancing mechanism HVX61_00635 ENOG4105BZU Histidine kinase HVX61_00640 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family HVX61_00645 ENOG4105C12 Phosphoribosylglycinamide synthetase HVX61_00680 ENOG41062WK cellular response to acidity HVX61_00685 ENOG4105K5X acetyltransferase HVX61_00695 ENOG4107QP3 malate synthase g HVX61_00700 ENOG4108I9X Isocitrate lyase HVX61_00715 ENOG41069M3 Transcriptional regulator HVX61_00720 ENOG4105C3R Methionine synthase HVX61_00725 ENOG4105EAM Na Pi-cotransporter HVX61_00735 ENOG4105DXH Alcohol dehydrogenase zinc-binding domain protein HVX61_00740 ENOG4105F3R pts system mannose fructose sorbose family iid HVX61_00745 ENOG4105ETZ PTS System HVX61_00755 ENOG4108XCU pts system HVX61_00760 ENOG4105CHR reductase HVX61_00765 ENOG4105DKT Transcriptional regulator HVX61_00770 ENOG4105FE9 pseudouridine synthase HVX61_00775 ENOG4108ZR5 Conserved Protein HVX61_00780 ENOG4105CFH Aspartokinase HVX61_00785 ENOG4107QP8 phosphohexose isomerase HVX61_00795 ENOG4108MDC (LipO)protein HVX61_00800 ENOG4108Q9C Periplasmic Protein HVX61_00805 ENOG4105E3R (LipO)protein HVX61_00820 ENOG4107QNK )-transporter HVX61_00825 ENOG4105EG2 ABC transporter, permease HVX61_00830 ENOG4105D56 permease protein HVX61_00835 ENOG4107FKK extracellular solute-binding protein family 1 HVX61_00840 ENOG4108IJ9 (ABC) transporter HVX61_00850 ENOG4107W52 maltose operon periplasmic protein HVX61_00875 ENOG41080IJ Diacylglycerol kinase HVX61_00885 ENOG4107R73 Mate efflux family protein HVX61_00890 ENOG4105VDW Csbd family HVX61_00895 ENOG4105MYN Zinc uptake regulation protein HVX61_00905 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) HVX61_00910 ENOG4105P4Z Phage shock protein G HVX61_00915 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein HVX61_00920 ENOG4105CDU Replicative dna helicase HVX61_00925 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) HVX61_00930 ENOG4105CGF Aromatic amino acid aminotransferase HVX61_00940 ENOG4105F0S class B acid phosphatase HVX61_00945 ENOG4108YXI Secondary thiamine-phosphate synthase enzyme HVX61_00950 ENOG4105MSB protein, conserved in bacteria HVX61_00955 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) HVX61_00960 ENOG4108UUM single-stranded DNA-binding protein HVX61_00965 ENOG4105PMV Membrane HVX61_00970 ENOG4108M8H domain protein HVX61_00975 ENOG4108W3Q Transcriptional regulator HVX61_00980 ENOG4108Z4X TRANSCRIPTIONal HVX61_00985 ENOG4105C7N Xanthine uracil vitamin C permease HVX61_00990 ENOG4105EEQ Na H antiporter HVX61_01005 ENOG41062QD Membrane HVX61_01010 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) HVX61_01020 ENOG4105JJ8 Cytochrome c nitrite reductase, pentaheme subunit HVX61_01025 ENOG4105D3S 4Fe-4S Ferredoxin, iron-sulfur binding domain protein HVX61_01030 ENOG4105DVI reductase, NrfD HVX61_01035 ENOG4108QKW cytochrome c-type biogenesis protein HVX61_01045 ENOG4108W0S formate-dependent nitrite reductase complex HVX61_01050 ENOG4105CK2 sodium dicarboxylate symporter HVX61_01055 ENOG41082ND Uncharacterized protein yjcO HVX61_01065 ENOG4105ETP RND efflux system, outer membrane lipoprotein HVX61_01070 ENOG4108MI0 Resistance protein HVX61_01075 ENOG4105J12 Multidrug resistance protein mdtN HVX61_01080 ENOG4106833 HVX61_01085 ENOG4105EUZ Beta-lactamase domain protein HVX61_01095 ENOG4105DW0 Catalyzes the ADP transfer to D-glycero-D-manno-heptose 1-phosphate, yielding ADP-D,D-heptose (By similarity) HVX61_01100 ENOG4105D2N Aldolase HVX61_01110 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator HVX61_01115 ENOG4105CNN ABC, transporter HVX61_01120 ENOG4105C2J ABC transporter HVX61_01130 ENOG4106ZVZ Escherichia coli IMT2125 genomic chromosome, IMT2125 HVX61_01135 ENOG4107SA6 carbon-phosphorus lyase complex accessory protein HVX61_01140 ENOG410849A acetyltransferase, (GNAT) family HVX61_01145 ENOG4105MFQ Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP) (By similarity) HVX61_01150 ENOG4105FD8 phosphonate metabolism protein PhnM HVX61_01155 ENOG4105HRV phosphonate c-p lyase system protein phnl HVX61_01160 ENOG4105ENV phosphonate C-P lyase system protein PhnK HVX61_01165 ENOG4105FT8 Phosphonate metabolism HVX61_01170 ENOG4105EKV Phosphonate metabolism protein HVX61_01175 ENOG4105KZ6 phosphonate C-P lyase system protein PhnH HVX61_01180 ENOG4105KQZ Phosphonate C-P lyase system protein PhnG HVX61_01185 ENOG4107RJJ Transcriptional regulator HVX61_01195 ENOG4105EHI Phosphonate ABC transporter, periplasmic HVX61_01200 ENOG4105D5T phosphonate abc transporter HVX61_01205 ENOG4108SQ4 Glyoxalase Bleomycin resistance protein (Dioxygenase HVX61_01210 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA HVX61_01215 ENOG4108F5E vimentin HVX61_01220 ENOG4108YIV HVX61_01225 ENOG4105CSH Transporter HVX61_01235 ENOG4105ECM Sensor protein basS pmrB HVX61_01240 ENOG4105XJC Two component transcriptional regulator (Winged helix family HVX61_01245 ENOG4105DIJ Phosphoethanolamine transferase HVX61_01250 ENOG4105D5Q Arginine ornithine antiporter HVX61_01255 ENOG4106ZGR Transcriptional regulator HVX61_01260 ENOG4105CXN decarboxylase HVX61_01265 ENOG4108K2B transcriptional regulator HVX61_01270 ENOG4105F8D glycoside hydrolase family 4 HVX61_01275 ENOG4105CT4 transporter HVX61_01280 ENOG4108R5S membrane HVX61_01285 ENOG4107GFK fumarate HVX61_01290 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter HVX61_01295 ENOG4108MRH transcriptional regulatory protein HVX61_01300 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism HVX61_01305 ENOG4105VR1 Pfam:DUF1271 HVX61_01310 ENOG410830R acetyltransferase HVX61_01325 ENOG4105CRK lysyL-tRNA synthetase HVX61_01330 ENOG4105DUX Transporter HVX61_01335 ENOG4105CXN decarboxylase HVX61_01340 ENOG4105D5Q Arginine ornithine antiporter HVX61_01345 ENOG4108M3R transcriptional activator CadC HVX61_01355 ENOG4108SIC Transcriptional regulator HVX61_01370 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter HVX61_01375 ENOG4108IJ0 Aspartate ammonia-lyase HVX61_01380 ENOG4108YH1 overproduction of this protein in Escherichia coli inhibits the F plasmid-mediated exclusion of bacteriophage T7 HVX61_01385 ENOG4105DVH amino acid HVX61_01400 ENOG4108ZVF (LipO)protein HVX61_01405 ENOG4105MTB Uncharacterized protein YjeJ HVX61_01410 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein HVX61_01420 ENOG4107PEH Entericidin EcnA/B family HVX61_01425 ENOG4106BSU Entericidin B HVX61_01430 ENOG4105KPY Small multidrug resistance protein HVX61_01435 ENOG4105QNF Outer membrane lipoprotein HVX61_01440 ENOG41066YJ Beta-lactamase HVX61_01455 ENOG4105E33 succinate dehydrogenase HVX61_01460 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) HVX61_01470 ENOG4107SC7 Inner membrane transporter yjeM HVX61_01475 ENOG4105EGS Mechanosensitive ion channel HVX61_01520 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) HVX61_01525 ENOG4105K8N protein family UPF0079, ATPase HVX61_01530 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase HVX61_01550 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) HVX61_01555 ENOG4107QJR hflk protein HVX61_01560 ENOG4105EPW hflc protein HVX61_01580 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) HVX61_01585 ENOG4105C2N RNA methyltransferase TrmH family group 3 HVX61_01590 ENOG4105FUX Conserved Protein HVX61_01595 ENOG4108P9J Phage shock protein A HVX61_01600 ENOG4107VNS Protein of unknown function (DUF2491) HVX61_01605 ENOG4105Z6B inner membrane protein yjfl HVX61_01610 ENOG4108KXT Conserved Protein HVX61_01615 ENOG4106032 Glutathionylspermidine synthase HVX61_01620 ENOG4105CSU acyl-Coa dehydrogenase HVX61_01625 ENOG4105S17 UPF0379 protein yjfN HVX61_01630 ENOG4105WSB biofilm stress and motility protein A HVX61_01635 ENOG4108MXZ Esterase HVX61_01650 ENOG4105CZC PTS system ascorbate-specific transporter subunit IIC HVX61_01655 ENOG410907W The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in ascorbate transport HVX61_01660 ENOG4106ETB IIa component HVX61_01680 ENOG4105KIT UPF0379 protein yjfY HVX61_01695 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) HVX61_01715 ENOG4108RS6 transposase HVX61_01720 ENOG4105D7V transposase HVX61_01730 ENOG4105FHY Opacity-associated protein A HVX61_01735 ENOG4108V1T peptidylprolyl cis-trans isomerase HVX61_01740 ENOG4105C85 amino acid HVX61_01750 ENOG4105DXC membrane HVX61_01755 ENOG4105ECR NmrA family HVX61_01760 ENOG4105KVH Transcriptional regulator HVX61_01765 ENOG4107RNS bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase 3'-nucleotidase periplasmic HVX61_01770 ENOG4108RNI 3'(2')5'-bisphosphate nucleotidase HVX61_01780 ENOG4108UUE Transcriptional regulator HVX61_01785 ENOG41061GZ Protein of unknown function (DUF1107) HVX61_01790 ENOG4105C37 (CBS) domain HVX61_01800 ENOG4105CFU surface antigen HVX61_01805 ENOG4105MA0 exported protein HVX61_01810 ENOG4108ZHD aig2 family HVX61_01815 ENOG41087RY SpoVT_AbrB HVX61_01820 ENOG4105MZG transcriptional modulator of maze toxin, mazf HVX61_01825 ENOG4105F0N pyrophosphate phospho-hydrolase HVX61_01830 ENOG4107R5U Periplasmic binding protein LacI transcriptional regulator HVX61_01835 ENOG4105C2J ABC transporter HVX61_01840 ENOG4107R9N ABC transporter HVX61_01845 ENOG41062B0 ABC transporter, permease HVX61_01855 ENOG4105DFU Cell wall formation (By similarity) HVX61_01865 ENOG4105CMS peptidase U62, modulator of DNA gyrase HVX61_01870 ENOG4108XVM Cytochrome b(562) HVX61_01875 ENOG4108RDD Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine (By similarity) HVX61_01880 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase HVX61_01885 ENOG4105CG3 alpha amylase, catalytic region HVX61_01890 ENOG4105C5Y PTS System HVX61_01895 ENOG4105D4X repressor HVX61_01905 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic HVX61_01910 ENOG4105KME endoribonuclease L-psp HVX61_01925 ENOG4107C93 pyrBI operon leader peptide HVX61_01930 ENOG4108UQ8 endoribonuclease L-psp HVX61_01935 ENOG4105F6U Short-chain dehydrogenase reductase Sdr HVX61_01940 ENOG4108XFH Transcriptional regulator HVX61_01945 ENOG4105XEP YhcH YjgK YiaL family protein HVX61_01960 ENOG4105KQT Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome (By similarity) HVX61_01965 ENOG4108MJ3 acetyltransferase HVX61_01970 ENOG4108M3P Membrane HVX61_01980 ENOG4105MYG DNA polymerase iii, chi subunit HVX61_01990 ENOG4108M8S permease YjgP YjgQ family protein HVX61_01995 ENOG4108K5H permease YjgP YjgQ family protein HVX61_02000 ENOG4105D7A ATP-binding protein HVX61_02005 ENOG4105DQ4 alcohol dehydrogenase HVX61_02035 ENOG4105FBQ ATPase associated with various cellular activities aaa_5 HVX61_02065 ENOG41069FU Outer membrane channel protein allowing the entry of N- acetylneuraminic acid (Neu5Ac, the most abundant sialic acid on host cell surfaces) into the bacteria HVX61_02070 ENOG4108W9T type 1 fimbriae regulatory protein HVX61_02075 ENOG4105E71 FimE is one of the 2 regulatory proteins which control the phase variation of type 1 fimbriae in E.coli. These proteins mediate the periodic inversion of a 300bp DNA segment that harbors the promoter for the fimbrial structural gene, fimA. FimE switches fimA off HVX61_02080 ENOG4108RQP Major type 1 subunit fimbrin HVX61_02085 ENOG4108S54 Fimbrial protein HVX61_02090 ENOG4108NAE Fimbrial chaperone protein HVX61_02095 ENOG4105CW0 outer membrane usher protein HVX61_02100 ENOG4108SQA Fimbrial HVX61_02105 ENOG4108T65 Fimbrial HVX61_02110 ENOG410643X FIMH SUBUNIT MANNOSE-sensitive type 1 fimbrial adhesin HVX61_02115 ENOG4107EFN gluconate transport system permease 3 HVX61_02125 ENOG4105DEI Mannitol dehydrogenase HVX61_02130 ENOG4105C6F GntR Family Transcriptional Regulator HVX61_02155 ENOG4107YNJ LysR family Transcriptional regulator HVX61_02160 ENOG4105DYB Isoaspartyl dipeptidase HVX61_02165 ENOG4108P2H Inner membrane protein YjiG HVX61_02170 ENOG41074DU domain protein HVX61_02180 ENOG4105TNG K13735 adhesin invasin HVX61_02185 ENOG4105CBP Major Facilitator HVX61_02190 ENOG4108ZK4 sdia-regulated domain-containing protein HVX61_02205 ENOG4105CIZ coA-substrate-specific enzyme activase HVX61_02210 ENOG4105DCU 2-hydroxyglutaryl-CoA dehydratase HVX61_02215 ENOG4106BRA Membrane HVX61_02220 ENOG41083G8 Multidrug resistance protein MdtM HVX61_02230 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HVX61_02235 ENOG4106DIZ Domain of unknown function (DUF1127) HVX61_02255 ENOG4105CVR type I restriction-modification system HVX61_02280 ENOG4105CKI cobalamin synthesis protein HVX61_02285 ENOG4105VCD cytoplasmic protein HVX61_02290 ENOG4105D22 carbon starvation protein HVX61_02295 ENOG4107UWN reductase HVX61_02300 ENOG4105EFA 4-hydroxyphenylacetate HVX61_02330 ENOG4107THI 3,4-dihydroxyphenylacetate 2,3-dioxygenase HVX61_02335 ENOG4105C26 Dehydrogenase HVX61_02340 ENOG4105ERH Fumarylacetoacetate hydrolase HVX61_02345 ENOG4108V8F Transcriptional regulator, MarR family HVX61_02350 ENOG4105C8Q Methyl-accepting chemotaxis HVX61_02355 ENOG4108I5G Major Facilitator superfamily HVX61_02360 ENOG410617M Transcriptional regulator HVX61_02365 ENOG4105CPQ Dehydrogenase HVX61_02375 ENOG4105RI1 glycoprotein receptor HVX61_02380 ENOG4106CVF DNA replication protein HVX61_02390 ENOG4107XM3 UPF0442 protein HVX61_02395 ENOG4105DWK Membrane HVX61_02400 ENOG4108N8T regulatoR HVX61_02405 ENOG4108T94 DNA-binding transcriptional activator BglJ HVX61_02410 ENOG4108819 ferric iron reductase HVX61_02415 ENOG4105YBH Protein of unknown function (DUF1435) HVX61_02435 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) HVX61_02440 ENOG4108WPU DNA polymerase III subunit psi HVX61_02445 ENOG4105KEG ribosomal-protein-alanine acetyltransferase HVX61_02450 ENOG4105PAD Hydrolase HVX61_02460 ENOG4105K3G Periplasmic Protein HVX61_02470 ENOG4108NRW Phospholipase, patatin family HVX61_02475 ENOG4105EYA deoxyribonuclease HVX61_02480 ENOG41076CZ activating enzyme HVX61_02485 ENOG4105G0K glycine radical enzyme YjjI family HVX61_02490 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) HVX61_02520 ENOG41062Z9 Membrane HVX61_02525 ENOG4105EAC phosphoserine phosphatase HVX61_02530 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) HVX61_02535 ENOG4107VZS Nicotinamide-nucleotide adenylyltransferase HVX61_02540 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HVX61_02545 ENOG4105RC8 Reduces the permeability of the outer membrane to copper. Seems to be involved in the regulation of biofilm formation. May decrease biofilm formation by repressing cell-cell interaction and cell surface interaction HVX61_02555 ENOG4105EWI Short-chain dehydrogenase reductase Sdr HVX61_02565 ENOG4107RSM transcriptional regulator HVX61_02570 ENOG4105C5H ABC transporter HVX61_02575 ENOG4107SC1 transglycosylase HVX61_02585 ENOG4108K16 Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) HVX61_02595 ENOG4105UEI Transcriptional Regulator AraC Family HVX61_02600 ENOG4108RH0 Crea protein HVX61_02605 ENOG4105E3W Two component transcriptional regulator (Winged helix family HVX61_02610 ENOG4105EB3 Histidine kinase HVX61_02615 ENOG4105CT7 inner membrane cred family protein HVX61_02620 ENOG41065U4 response regulator HVX61_02625 ENOG410759A HVX61_02630 ENOG4106FVC RNA methyltransferase HVX61_02645 ENOG4105CFH Aspartokinase HVX61_02655 ENOG4105D98 threonine synthase HVX61_02660 ENOG41062C6 Protein of unknown function (DUF2502) HVX61_02670 ENOG4105BZG amino acid carrier protein HVX61_02675 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) HVX61_02680 ENOG4108RIR Molybdenum cofactor biosynthesis protein HVX61_02685 ENOG4106HK8 GPR1 FUN34 yaaH family protein HVX61_02690 ENOG4108QUJ UPF0174 protein YaaW HVX61_02710 ENOG4105WI6 cell killing protein encoded within cryptic prophage HVX61_02720 ENOG41063Z6 transcriptional regulator, lysR family HVX61_02730 ENOG4105CW0 outer membrane usher protein HVX61_02735 ENOG4108MQF Chaperone HVX61_02765 ENOG410647N response to DNA damage stimulus HVX61_02770 ENOG4105DTN riboflavin biosynthesis protein ribF HVX61_02775 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) HVX61_02785 ENOG41090X3 Peptidyl-prolyl cis-trans isomerase HVX61_02805 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain HVX61_02810 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain HVX61_02815 ENOG4108XNW Transcriptional activatory protein CaiF HVX61_02825 ENOG4106YT9 Enoyl-CoA hydratase HVX61_02860 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase HVX61_02865 ENOG4105IBM Could be part of an electron transfer system required for anaerobic carnitine reduction. Could be a 3Fe-4S cluster- containing protein HVX61_02870 ENOG4105C54 Major Facilitator superfamily HVX61_02880 ENOG4105CKD glutathione-regulated potassium-efflux system protein HVX61_02885 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) HVX61_02920 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) HVX61_02930 ENOG41066UG Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host (By similarity) HVX61_02945 ENOG4105D3G Pseudouridine synthase HVX61_02950 ENOG4105BZK Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair (By similarity) HVX61_02955 ENOG4105CQ2 DNA polymerase HVX61_02960 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase HVX61_02975 ENOG41063TF transcriptional regulator (AraC HVX61_02980 ENOG4108KF1 Membrane HVX61_02990 ENOG4106SMU thiamine transporter membrane protein HVX61_02995 ENOG4105DP9 ABC transporter HVX61_03005 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) HVX61_03030 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) HVX61_03045 ENOG41064T2 transcriptional regulator, lysR family HVX61_03050 ENOG4105C7K acetolactate synthase HVX61_03055 ENOG4108ZP8 Acetolactate synthase small subunit HVX61_03065 ENOG4107B7Y DNA-binding transcriptional regulator FruR HVX61_03080 ENOG41063Y6 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) HVX61_03085 ENOG4105CJN penicillin-binding protein HVX61_03090 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) HVX61_03095 ENOG4108EQQ Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity) HVX61_03105 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) HVX61_03110 ENOG4105CNI cell division protein FtsW HVX61_03125 ENOG4105CPF Cell wall formation (By similarity) HVX61_03130 ENOG4105K7E Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity) HVX61_03135 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) HVX61_03140 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) HVX61_03160 ENOG4105M6F mutator MutT protein HVX61_03175 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) HVX61_03190 ENOG4105D7Q type ii secretion system HVX61_03195 ENOG4107QHF type ii secretion system protein e HVX61_03200 ENOG4108ZUW Major pilin subunit HVX61_03205 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase HVX61_03210 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase HVX61_03215 ENOG4106A72 regulatory protein AmpE HVX61_03220 ENOG4105C85 amino acid HVX61_03225 ENOG41073TP transcriptional regulator HVX61_03230 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) HVX61_03235 ENOG4107QSN dihydrolipoamide acetyltransferase HVX61_03240 ENOG4107QN2 dihydrolipoyl dehydrogenase HVX61_03245 ENOG4108NST exported protein HVX61_03250 ENOG4107QIJ Aconitate hydratase 2 HVX61_03270 ENOG4108ZRK uncharacterized protein yacC HVX61_03275 ENOG4105E3B Multicopper oxidase HVX61_03280 ENOG4105DZG Dehydrogenase HVX61_03285 ENOG4108UGV hypoxanthine phosphoribosyltransferase HVX61_03290 ENOG41077A9 carbonic anhydrase HVX61_03295 ENOG4105DA5 (ABC) transporter HVX61_03300 ENOG4105E3A (ABC) transporter HVX61_03305 ENOG4108YTN IIa component HVX61_03310 ENOG4107BJW polysaccharide deacetylase HVX61_03320 ENOG4108A32 Transposase HVX61_03345 ENOG4105SYG Fimbrial protein HVX61_03350 ENOG4108XEY fimbrial-like adhesin protein HVX61_03355 ENOG4105CW0 outer membrane usher protein HVX61_03360 ENOG4108VEV chaperone HVX61_03370 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase HVX61_03375 ENOG4105DJ0 Poly(A) Polymerase HVX61_03380 ENOG4106F3G Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity) HVX61_03395 ENOG4107XID 2'-5' rna ligase HVX61_03400 ENOG4105CQ7 ATP-dependent helicase HVX61_03405 ENOG4105BZ4 penicillin-binding protein HVX61_03410 ENOG4105E0K tonB-dependent siderophore receptor HVX61_03415 ENOG4105E0A ABC, transporter HVX61_03420 ENOG4105J76 Periplasmic binding protein HVX61_03425 ENOG4105S6R Iron-hydroxamate transporter permease subunit HVX61_03450 ENOG4105EN6 Membrane HVX61_03455 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) HVX61_03470 ENOG4105C0H protease HVX61_03475 ENOG4108IXP Carbohydrate diacid transcriptional activator CdaR HVX61_03495 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) HVX61_03520 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) HVX61_03525 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) HVX61_03530 ENOG4105KNE Phosphatidate cytidylyltransferase HVX61_03535 ENOG4105DZP Membrane-associated zinc metalloprotease HVX61_03545 ENOG4108RFI Molecular chaperone that interacts specifically with outer membrane proteins, thus maintaining the solubility of early folding intermediates during passage through the periplasm (By similarity) HVX61_03550 ENOG4105D7M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) HVX61_03575 ENOG4105C0B DNA polymerase III (alpha subunit) HVX61_03585 ENOG4105CXN decarboxylase HVX61_03590 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase HVX61_03595 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) HVX61_03600 ENOG4105M1T rho-binding antiterminator HVX61_03610 ENOG4108VWS Yaeq family HVX61_03615 ENOG4108YZN class I peptide chain release factor HVX61_03620 ENOG4107EII Lipoprotein involved with copper homeostasis and adhesion HVX61_03630 ENOG4108UY0 (LipO)protein HVX61_03640 ENOG4108R96 Methyltransferase, YaeB family HVX61_03645 ENOG4108R8X outer membrane lipoprotein HVX61_03650 ENOG4105D01 (LipO)protein HVX61_03655 ENOG4108UMI ABC transporter, permease HVX61_03660 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) HVX61_03665 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase HVX61_03700 ENOG4105CV8 reductase HVX61_03705 ENOG4105HEI LysR family (Transcriptional regulator HVX61_03715 ENOG4105F2W methyltransferase HVX61_03720 ENOG4105E9H Lytic Murein transglycosylase HVX61_03725 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) HVX61_03730 ENOG4105D1A Methyltransferase HVX61_03740 ENOG4107RZZ dna polymerase iii epsilon subunit HVX61_03750 ENOG410600K aminopeptidase HVX61_03780 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit HVX61_03830 ENOG4108WC9 type VI secretion system effector, hcp1 family HVX61_03835 ENOG4105CS6 Rhs element vgr protein HVX61_03890 ENOG4105CZ7 nitrilase cyanide hydratase and apolipoprotein n-acyltransferase HVX61_03895 ENOG4108WN0 inhibitor of vertebrate lysozyme HVX61_03900 ENOG4107QPN acyl-Coa dehydrogenase HVX61_03910 ENOG4105E7A Glutamine amidotransferase HVX61_03915 ENOG4105F7V ErfK ybiS ycfS ynhG family protein HVX61_03920 ENOG4105VXN addiction module toxin, RelE StbE family HVX61_03930 ENOG4108YS0 lipoprotein YafL HVX61_03935 ENOG4108UK5 Transposase HVX61_03945 ENOG4105D00 flagellar biosynthetic protein flhB HVX61_03950 ENOG4105D19 Role in flagellar biosynthesis (By similarity) HVX61_03955 ENOG4105VS8 Flagellar biosynthetic protein fliq HVX61_03960 ENOG4105CN7 Flagellar biosynthetic protein FliP HVX61_03965 ENOG4105DD5 Flagellar motor switch protein HVX61_03990 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) HVX61_04000 ENOG4108JIR Flagellum-specific ATP synthase HVX61_04010 ENOG4107ZIC Glycerol-3-phosphate cytidylyltransferase HVX61_04050 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) HVX61_04055 ENOG4108ZC9 flagellar basal-body rod protein flgc HVX61_04065 ENOG4105BZE flagellar hook protein, FlgE HVX61_04070 ENOG4108KPB Flagellar basal-body rod protein FlgF HVX61_04075 ENOG4105CGA flagellar basal-body rod protein FlgG HVX61_04090 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj HVX61_04100 ENOG4105DTJ flagellar hook-associated protein HVX61_04115 ENOG4105I03 Flagellin HVX61_04120 ENOG410804A Flagellar hook-associated 2 domain-containing protein HVX61_04150 ENOG4107RD7 Flagellar Motor Protein, MotA HVX61_04165 ENOG4108HYG acetyltransferase HVX61_04175 ENOG4108S2Y peptide Chain Release factor HVX61_04180 ENOG4105CIN aminoacyl-histidine dipeptidase HVX61_04190 ENOG4105V1F Fermentation respiration switch protein HVX61_04200 ENOG4105FCK Membrane HVX61_04220 ENOG4105DFP Integrase HVX61_04305 ENOG4105DZR Type I site-specific deoxyribonuclease HVX61_04325 ENOG4105EMU Dehydrogenase HVX61_04335 ENOG4105EQ2 LysR family Transcriptional regulator HVX61_04345 ENOG4107RTG Major Facilitator superfamily HVX61_04350 ENOG4107XAN XdhC and CoxI family HVX61_04355 ENOG4105C7W Xanthine dehydrogenase HVX61_04360 ENOG4105DIP Molybdopterin dehydrogenase FAD-binding HVX61_04365 ENOG4107XKX isoquinoline 1-oxidoreductase, alpha subunit HVX61_04375 ENOG4105R3P Inner membrane protein yagU HVX61_04380 ENOG4105PI0 Ferredoxin HVX61_04390 ENOG4106PYX Receptor HVX61_04395 ENOG4108N3D putative enzyme HVX61_04405 ENOG4108GWT fimbrillin MatB HVX61_04435 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HVX61_04440 ENOG4105ENX hydrolase HVX61_04445 ENOG410642W LysR family Transcriptional regulator HVX61_04450 ENOG4105EQ2 LysR family Transcriptional regulator HVX61_04455 ENOG4107SET aldo keto reductase HVX61_04465 ENOG4105TNG K13735 adhesin invasin HVX61_04475 ENOG4105CV8 reductase HVX61_04480 ENOG4108KBJ Inner membrane protein YkgB HVX61_04485 ENOG41066GK UPF0379 protein ykgI HVX61_04490 ENOG4107QN2 dihydrolipoyl dehydrogenase HVX61_04495 ENOG4108K01 transcriptional regulator HVX61_04500 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) HVX61_04505 ENOG4107QR9 Iron-sulfur cluster binding protein HVX61_04510 ENOG4108ZZK Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source (By similarity) HVX61_04535 ENOG4105BZU Histidine kinase HVX61_04540 ENOG4108W9T type 1 fimbriae regulatory protein HVX61_04565 ENOG4105C94 Transporter HVX61_04570 ENOG4105BZU Histidine kinase HVX61_04575 ENOG4108NUU Transcriptional regulator HVX61_04580 ENOG4105SZ2 membrAne HVX61_04585 ENOG4107SNB ankyrin repeat protein YahD HVX61_04590 ENOG4105N16 Protein of unknown function (DUF2877) HVX61_04595 ENOG4107R1Q Membrane protein FdrA HVX61_04600 ENOG4107REC cytoplasmic protein HVX61_04610 ENOG4105C5B carbamate kinase HVX61_04615 ENOG4105DZC cytosine deaminase HVX61_04620 ENOG4105DQ4 alcohol dehydrogenase HVX61_04635 ENOG4105E82 cytochrome subunit of dehydrogenase HVX61_04640 ENOG4105TDT uncharacterized protein yahO HVX61_04645 ENOG4108JU7 Transcriptional regulator HVX61_04650 ENOG4105CR4 methylisocitrate lyase HVX61_04655 ENOG4105BZN citrate synthase HVX61_04660 ENOG4105DXD 2-methylcitrate dehydratase HVX61_04665 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) HVX61_04670 ENOG4105DQW permease for cytosine purines, uracil, thiamine, allantoin HVX61_04675 ENOG4105DZC cytosine deaminase HVX61_04680 ENOG4105DND Transcriptional regulator HVX61_04685 ENOG4107B2H carbonic anhydrase HVX61_04695 ENOG4105DJ2 Major Facilitator Superfamily HVX61_04700 ENOG4108UW5 maltose o-acetyltransferase HVX61_04705 ENOG4105U0F oligosaccharide H symporter, major facilitator superfamily (MFS) HVX61_04710 ENOG4105CNT hydrolase family 2 HVX61_04715 ENOG4105ETE Transcriptional regulator (LacI family HVX61_04725 ENOG4105IGJ Zn-dependent Hydrolase of the beta-lactamase fold protein HVX61_04730 ENOG4108K2P TRANSCRIPTIONal HVX61_04745 ENOG4106HB6 Alpha beta hydrolase HVX61_04765 ENOG4108SC4 )-transporter HVX61_04770 ENOG4105IUQ nucleoprotein polynucleotide-associated enzyme HVX61_04775 ENOG4105C4W S-formylglutathione hydrolase HVX61_04790 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HVX61_04795 ENOG4107RCV ABC transporter, permease HVX61_04800 ENOG4105C4Y ABC transporter HVX61_04805 ENOG4105CXY transporter HVX61_04810 ENOG4105BZU Histidine kinase HVX61_04815 ENOG4108KX4 response regulator HVX61_04820 ENOG4106FTQ Taurine ABC transporter, periplasmic HVX61_04825 ENOG4108ETV ABC transporter HVX61_04830 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component HVX61_04835 ENOG4105E2B Taurine dioxygenase HVX61_04840 ENOG4105D52 delta-aminolevulinic acid dehydratase HVX61_04850 ENOG4108PNB DNA-binding transcriptional regulator HVX61_04855 ENOG4107R6D beta-lactam binding protein AmpH HVX61_04860 ENOG4108DQG in Escherichia coli SbmA is involved in uptake of microcin J25 HVX61_04865 ENOG4107QS8 (LipO)protein HVX61_04870 ENOG4105FR5 inner membrane protein YaiY HVX61_04875 ENOG4105UNH Membrane HVX61_04880 ENOG4105CPF Cell wall formation (By similarity) HVX61_04895 ENOG4105G6Z alkaline phosphatase HVX61_04900 ENOG4105VIF phosphate starvation-inducible protein HVX61_04905 ENOG4105BZU Histidine kinase HVX61_04910 ENOG4105II7 pyrroline-5-carboxylate reductase HVX61_04925 ENOG4105SS3 HVX61_04930 ENOG4105HBA AroM protein HVX61_04955 ENOG4105DKQ ROK family HVX61_04960 ENOG4105F27 Major Facilitator HVX61_04965 ENOG4105EYH Exonuclease HVX61_04970 ENOG4107RH8 nuclease SbcCD subunit D HVX61_04975 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HVX61_04980 ENOG4105BZU Histidine kinase HVX61_04985 ENOG4105CWM branched-chain amino acid transport system II carrier protein HVX61_04990 ENOG4105C85 amino acid HVX61_04995 ENOG4107R28 alpha amylase, catalytic region HVX61_05005 ENOG4108ZYK Acyl carrier protein phosphodiesterase HVX61_05020 ENOG4105VIE preprotein translocase, subunit YajC HVX61_05025 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) HVX61_05030 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) HVX61_05035 ENOG4105N1F Hnh endonuclease HVX61_05040 ENOG4105DRB nucleoside-specific channel-forming protein HVX61_05045 ENOG4108KIC (LipO)protein HVX61_05055 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) HVX61_05060 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) HVX61_05070 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) HVX61_05075 ENOG4108ZAI phosphatidylglycerophosphatase a HVX61_05085 ENOG4105CPC Aldo Keto reductase HVX61_05095 ENOG4105CTB Polyprenyl synthetase HVX61_05110 ENOG4107S0N DJ-1 family HVX61_05115 ENOG4108JZF Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) HVX61_05125 ENOG4107RDB Major Facilitator HVX61_05150 ENOG41090KH cytochrome o ubiquinol oxidase (subunit iv) HVX61_05155 ENOG4105CCU oxidase (Subunit III) HVX61_05160 ENOG4105BZ9 Cytochrome C oxidase, subunit I HVX61_05165 ENOG4105E2S oxidase) subunit II HVX61_05170 ENOG4105EYM Major Facilitator superfamily HVX61_05175 ENOG4105IEY (LipO)protein HVX61_05180 ENOG4105M85 Bola protein HVX61_05200 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) HVX61_05205 ENOG4105K70 DNA-binding protein HVX61_05210 ENOG4105EIN peptidylprolyl cis-trans isomerase HVX61_05215 ENOG41083P1 competence protein ComEA helix-hairpin-helix repeat protein HVX61_05220 ENOG4108TGP Thioesterase superfamily protein HVX61_05230 ENOG4108NFA extracellular solute-binding protein HVX61_05240 ENOG4108XM1 transcriptional regulator AsnC family HVX61_05245 ENOG4105BZ1 (ABC) transporter HVX61_05250 ENOG4105BZ1 (ABC) transporter HVX61_05255 ENOG4108YZA Nitrogen regulatory protein pii HVX61_05260 ENOG4105BZU Histidine kinase HVX61_05265 ENOG4105C29 acyl-CoA thioesterase HVX61_05270 ENOG4108MNP Glycoprotein polysaccharide metabolism HVX61_05275 ENOG41080UX Methyltransferase HVX61_05285 ENOG4105KCV RNA signal recognition particle 4.5S RNA HVX61_05290 ENOG41066DG (EAL) domain protein HVX61_05295 ENOG4105GSJ Inner membrane protein ylaC HVX61_05300 ENOG4108UW5 maltose o-acetyltransferase HVX61_05305 ENOG4105KF5 hemolysin expression-modulating protein HVX61_05310 ENOG4108UKR Biofilm formation regulator YbaJ HVX61_05315 ENOG4105BZS acriflavin resistance protein HVX61_05320 ENOG4105C1P efflux transporter, rnd family, mfp subunit HVX61_05325 ENOG4107XI7 Tetr family transcriptional regulator HVX61_05330 ENOG4105EGS Mechanosensitive ion channel HVX61_05335 ENOG4106428 Protein of unknown function (DUF2496) HVX61_05340 ENOG4108URS primosomal replication protein n'' HVX61_05345 ENOG4105WD1 Membrane HVX61_05355 ENOG4107QMP dna polymerase iii subunits gamma and tau HVX61_05390 ENOG4107RE1 Inosine-guanosine kinase HVX61_05395 ENOG4105CKD glutathione-regulated potassium-efflux system protein HVX61_05400 ENOG4105EU0 Major facilitator Superfamily HVX61_05405 ENOG4105CGH 5'-nucleotidase HVX61_05410 ENOG4108Z66 YbaK ebsC protein HVX61_05415 ENOG4105MBR gumn family HVX61_05420 ENOG41081XE plasmid maintenance system antidote protein, xre family HVX61_05425 ENOG4105C59 p-type ATPase HVX61_05430 ENOG4105CSV Glutaminase HVX61_05435 ENOG4107RY6 amino acid HVX61_05460 ENOG4107QZV Type I secretion membrane fusion protein HVX61_05490 ENOG4105G5H Membrane HVX61_05495 ENOG4107QX8 SPFH domain, Band 7 family protein HVX61_05500 ENOG41083J0 (ABC) transporter HVX61_05505 ENOG4105C4B ABC transporter, permease HVX61_05510 ENOG4107QR8 Thioredoxin HVX61_05515 ENOG4105E1F short-chain dehydrogenase reductase HVX61_05520 ENOG4108UJV acyl-CoA thioesterase i HVX61_05525 ENOG4108I0Y (ABC) transporter HVX61_05530 ENOG4105CV6 ABC transporter, permease HVX61_05540 ENOG4107653 Transcriptional regulator HVX61_05550 ENOG4108N16 Negative regulator of allantoin and glyoxylate utilization operons. Binds to the gcl promoter and to the allS- allA intergenic region HVX61_05555 ENOG41060W2 glyoxylate carboligase HVX61_05560 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) HVX61_05565 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase HVX61_05570 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease HVX61_05580 ENOG4105DTE Xanthine uracil vitamin C permease HVX61_05585 ENOG4105BZW Glycerate kinase HVX61_05590 ENOG4105S0E allantoin catabolism protein HVX61_05595 ENOG4105CE7 Amidase, hydantoinase carbamoylase family HVX61_05600 ENOG4105DG4 malate L-lactate dehydrogenase HVX61_05605 ENOG4107R1Q Membrane protein FdrA HVX61_05610 ENOG4107REC cytoplasmic protein HVX61_05615 ENOG4105G5A Protein of unknown function (DUF2877) HVX61_05620 ENOG4105C5B carbamate kinase HVX61_05625 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit HVX61_05630 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) HVX61_05640 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) HVX61_05650 ENOG4105S2T inner membrane protein YbcI HVX61_05655 ENOG4105WQ3 Rna-binding protein HVX61_05665 ENOG4108WDE Fimbrial protein HVX61_05670 ENOG4108AF8 Chaperone HVX61_05675 ENOG4105CW0 outer membrane usher protein HVX61_05680 ENOG4108M66 Involved in regulation of length and mediation of adhesion of SfmA fimbriae (but not necessary for the production of fimbriae). Seems to be mannose binding adhesin (By similarity) HVX61_05685 ENOG4108ZI2 Fimbrial protein HVX61_05690 ENOG4108Q9V regulatoR HVX61_05700 ENOG4108KU3 Integrase HVX61_05710 ENOG41077V0 CPS-53 (KpLE1) prophage HVX61_05715 ENOG4108R7K Metal Dependent Phosphohydrolase HVX61_05720 ENOG4108HJ1 Uncharacterized conserved protein (DUF2303) HVX61_05725 ENOG4105H40 HVX61_05750 ENOG4108S1U HVX61_05775 ENOG4106CZA Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC (By similarity) HVX61_05785 ENOG4108MXB Protein of unknown function (DUF968) HVX61_05790 ENOG4105HRS Antitermination protein HVX61_05800 ENOG4105QFS Lysis protein S homolog from lambdoid prophage HVX61_05805 ENOG4105KUS lysozyme HVX61_05815 ENOG4105QYK bacteriophage lambda Bor protein homolog HVX61_05830 ENOG4106YSC HVX61_05835 ENOG4105FKG DNA packaging protein HVX61_05840 ENOG4105UZW Tail fiber assembly protein HVX61_05845 ENOG4107DE1 head-to-tail joining protein HVX61_05855 ENOG4105F7J membrane-bound serine protease HVX61_05865 ENOG4105IM0 capsid protein HVX61_05940 ENOG4108X9F tail fiber protein HVX61_05945 ENOG4105UZW Tail fiber assembly protein HVX61_05950 ENOG4105WEF catalase HVX61_05955 ENOG4108N8X transition metal ion binding HVX61_05960 ENOG4108Z9Z response to DNA damage stimulus HVX61_05970 ENOG4108WF3 methyltransferase HVX61_05975 ENOG4108NC2 Outer membrane protease HVX61_05985 ENOG4105QUW HVX61_05990 ENOG41090FC Bacteriophage N4 receptor, outer membrane subunit HVX61_05995 ENOG410802X bacteriophage n4 adsorption protein b HVX61_06000 ENOG4105GR3 Histidine kinase HVX61_06005 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HVX61_06010 ENOG4105ENJ RND efflux system, outer membrane lipoprotein HVX61_06015 ENOG410624V efflux system protein HVX61_06020 ENOG4105EP1 Efflux transporter rnd family, mfp subunit HVX61_06025 ENOG4108IJF Heavy metal efflux pump, CzcA HVX61_06030 ENOG4105C85 amino acid HVX61_06035 ENOG4105CUY Mechanosensitive ion channel HVX61_06040 ENOG4108RCM Nitroreductase HVX61_06045 ENOG4105MSB protein, conserved in bacteria HVX61_06050 ENOG4105WQ6 Membrane HVX61_06070 ENOG4108TSE Transferase HVX61_06075 ENOG4107RNH Outer membrane receptor FepA HVX61_06080 ENOG4105E93 esterase HVX61_06085 ENOG41085A6 mbth domain-containing protein HVX61_06090 ENOG4105C0W non-ribosomal peptide synthetase HVX61_06095 ENOG4108QY5 Ferric enterobactin transport protein HVX61_06100 ENOG4105E0A ABC, transporter HVX61_06105 ENOG4105TVJ transport system, permease HVX61_06110 ENOG4105DQ5 transport system permease protein HVX61_06120 ENOG4105PEC Iron-enterobactin transporter periplasmic binding protein HVX61_06125 ENOG4105E4F Isochorismate synthase HVX61_06130 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase HVX61_06135 ENOG4105WQI isochorismatase HVX61_06140 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase HVX61_06145 ENOG4108TZA Required for optimal enterobactin synthesis. Acts as a proofreading enzyme that prevents EntB misacylation by hydrolyzing the thioester bound existing between EntB and wrongly charged molecules (By similarity) HVX61_06150 ENOG4105D22 carbon starvation protein HVX61_06155 ENOG4105VCD cytoplasmic protein HVX61_06160 ENOG4107SCQ Iron-containing alcohol dehydrogenase HVX61_06165 ENOG4105CHM Aminotransferase HVX61_06170 ENOG4105GTN ParB Domain Protein Nuclease HVX61_06175 ENOG4105BZV Phosphoadenosine phosphosulfate reductase HVX61_06180 ENOG4105DQS Transcriptional regulator HVX61_06185 ENOG4108KHN disulfide isomerase, thiol-disulfide oxidase HVX61_06190 ENOG4105D3R alkyl hydroperoxide reductase HVX61_06195 ENOG4108JU3 Alkyl hydroperoxide reductase HVX61_06200 ENOG4108U51 Universal stress protein HVX61_06210 ENOG4105NXH GreA GreB family elongation factor HVX61_06215 ENOG4105KTS ribonuclease HVX61_06220 ENOG4107QPK )-transporter HVX61_06235 ENOG4105CHY citrate lyase, alpha HVX61_06240 ENOG4105CI0 Citrate lyase HVX61_06250 ENOG4105DUA (citrate (pro-3S)-lyase ligase HVX61_06255 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism HVX61_06260 ENOG4106YYS transcriptional regulatory protein HVX61_06265 ENOG4105CEE C4-dicarboxylate transporter HVX61_06270 ENOG41079UR PagP is required both for biosynthesis of hepta-acylated lipid A species containing palmitate and for resistance to cationic antimicrobial peptides (CAMPs). It catalyzes the transfer of a palmitate chain (16 0) from the sn-1 position of a glycerophospholipid to the free hydroxyl group of the (R)-3- hydroxymyristate chain at position 2 of lipid A (endotoxin) (By similarity) HVX61_06290 ENOG410607N Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatE shares overlapping functions with TatA (By similarity) HVX61_06300 ENOG41064T2 transcriptional regulator, lysR family HVX61_06315 ENOG4105DZ1 carboxypeptidase HVX61_06320 ENOG4105K6T rare lipoprotein A HVX61_06325 ENOG4105CNI cell division protein FtsW HVX61_06330 ENOG4105CJN penicillin-binding protein HVX61_06340 ENOG4105KEM Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) HVX61_06345 ENOG4108TGR phosphatase HVX61_06355 ENOG4105DJF DNA polymerase III, delta' subunit HVX61_06370 ENOG4107PAI alpha helical protein HVX61_06375 ENOG4105EUU Sel1 domain protein repeat-containing protein HVX61_06380 ENOG41069CF Protein of unknown function (DUF1266) HVX61_06385 ENOG4105QFC Hsc56 co-chaperone of HscC HVX61_06390 ENOG4107JFD Sel1 repeat HVX61_06395 ENOG41069CF Protein of unknown function (DUF1266) HVX61_06405 ENOG4105F7F Chaperone HVX61_06415 ENOG4105CDA abc transporter atp-binding protein HVX61_06420 ENOG4105DRP amino acid AbC transporter HVX61_06425 ENOG4105EAD ABC transporter HVX61_06430 ENOG4107RP9 extracellular solute-binding protein, family 3 HVX61_06435 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) HVX61_06440 ENOG4108JU5 Magnesium and cobalt efflux protein HVX61_06450 ENOG4105C9A Phoh family HVX61_06460 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family HVX61_06500 ENOG4105CAQ asparagine synthetase HVX61_06505 ENOG4105D4U had-superfamily hydrolase, subfamily iia HVX61_06510 ENOG4105E2R ROK family HVX61_06515 ENOG4105CE4 GlcNAc 6-P deacetylase HVX61_06525 ENOG4105CI1 PTS System HVX61_06540 ENOG4105GX6 (LipO)protein HVX61_06545 ENOG41090R7 Ferric uptake HVX61_06555 ENOG4105MHQ Low-potential electron donor to a number of redox enzymes (By similarity) HVX61_06560 ENOG4105NNH LexA regulated protein HVX61_06565 ENOG4105EV9 Alpha Beta Hydrolase HVX61_06570 ENOG4107CDU Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated (By similarity) HVX61_06575 ENOG4107QIX Phosphoglucomutase (EC 5.4.2.2 HVX61_06580 ENOG4105EEX Two component transcriptional regulator (Winged helix family HVX61_06585 ENOG4105C08 Histidine kinase HVX61_06610 ENOG4105XIQ Protein of unknown function (DUF2517) HVX61_06615 ENOG4107SEY Conserved Protein HVX61_06620 ENOG4105CVP deoxyribo-dipyrimidine photolyase HVX61_06625 ENOG4105DUX Transporter HVX61_06630 ENOG4107QNR UPF0135 protein HVX61_06635 ENOG4105P4J Allophanate hydrolase, subunit 1 HVX61_06640 ENOG4107R7A Allophanate hydrolase subunit 2 HVX61_06650 ENOG4108S0J Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized pyrimidines, such as thymine glycol, 5,6-dihydrouracil and 5,6-dihydrothymine. Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'- phosphates (By similarity) HVX61_06655 ENOG4108KK1 membrane protein AbrB duplication HVX61_06660 ENOG4108MY7 Fimbrial HVX61_06665 ENOG4108TTM chaperone HVX61_06670 ENOG4106PG1 outer membrane usher protein HVX61_06675 ENOG4106UBK fimbrial-like adhesin protein HVX61_06680 ENOG4105BZN citrate synthase HVX61_06690 ENOG4108UTY succinate dehydrogenase, cytochrome b556 subunit HVX61_06695 ENOG4105N1I succinate dehydrogenase, hydrophobic membrane anchor protein HVX61_06700 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) HVX61_06705 ENOG4105E33 succinate dehydrogenase HVX61_06710 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 HVX61_06715 ENOG4105C7S Dehydrogenase HVX61_06725 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha HVX61_06730 ENOG4105ETT transcriptional Regulator, LysR family HVX61_06735 ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase HVX61_06740 ENOG4107GFK fumarate HVX61_06745 ENOG4105CK2 sodium dicarboxylate symporter HVX61_06765 ENOG4105DJI Methylaspartate mutase, E subunit HVX61_06775 ENOG4107WFU Glutamate mutase subunit sigma HVX61_06790 ENOG4105C4M (Ubiquinol oxidase) subunit I HVX61_06795 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii HVX61_06805 ENOG4105KJB cyd operon protein YbgE HVX61_06810 ENOG4107YD3 Thioesterase HVX61_06815 ENOG4105E02 MotA TolQ exbB proton channel HVX61_06825 ENOG4108Z82 Cell envelope integrity inner membrane protein TolA HVX61_06835 ENOG4105KCK Peptidoglycan-associated lipoprotein HVX61_06840 ENOG4105UFD tol-pal system protein YbgF HVX61_06885 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) HVX61_06890 ENOG4106Z1T Nicotinamide Mononucleotide Transporter HVX61_06895 ENOG4105PGM cation diffusion facilitator family transporter HVX61_06900 ENOG4105JND homeobox protein HVX61_06905 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) HVX61_06915 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) HVX61_06925 ENOG4105F0Z galactose-1-phosphate uridylyltransferase HVX61_06930 ENOG4105CMR udp-glucose 4-epimerase HVX61_06935 ENOG4105DKW ABC transporter HVX61_06940 ENOG4105F4R Transcriptional regulator mode HVX61_06950 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein HVX61_06955 ENOG4105E0C molybdate abc transporter HVX61_06965 ENOG4108K4B hydrolase HVX61_06975 ENOG4105F04 LysR family Transcriptional regulator HVX61_06980 ENOG4105C7F AcnD-accessory protein PrpF HVX61_06985 ENOG4107QPK )-transporter HVX61_06990 ENOG4107QM5 aconitate hydratase HVX61_06995 ENOG4105NBR Pectinesterase HVX61_07000 ENOG4108I1J Integrase HVX61_07020 ENOG4105CKK Glycosyl transferase, family 2 HVX61_07025 ENOG4105IHM Involved in O antigen modification. Involved in the translocation of bactoprenol-linked glucose across the cytoplasmic membrane (By similarity) HVX61_07035 ENOG4108V1U phospholipid-binding protein HVX61_07045 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) HVX61_07060 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) HVX61_07065 ENOG4105E78 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) HVX61_07075 ENOG4105CHW UPF0052 protein HVX61_07085 ENOG4108RIR Molybdenum cofactor biosynthesis protein HVX61_07095 ENOG4105M00 molybdopterin converting factor, subunit 1 HVX61_07100 ENOG4108ZAF Molybdopterin HVX61_07105 ENOG4105HFZ Membrane HVX61_07110 ENOG410733J conserved inner membrane protein HVX61_07115 ENOG4107UXM Membrane HVX61_07120 ENOG4105DZQ phospholipase D Transphosphatidylase HVX61_07125 ENOG4105X23 Endonuclease Exonuclease phosphatase HVX61_07130 ENOG4105I9U inner membrane protein ybhQ HVX61_07135 ENOG4107QWP ABC-2 type transporter HVX61_07140 ENOG4107QWP ABC-2 type transporter HVX61_07145 ENOG4105CJ1 ABC, transporter HVX61_07155 ENOG4107MVR Transcriptional regulator HVX61_07160 ENOG4105C1J atp-dependent rna helicase HVX61_07175 ENOG4105DVT helicase HVX61_07180 ENOG4108MTB glycosyl transferase family HVX61_07185 ENOG4105DG4 malate L-lactate dehydrogenase HVX61_07190 ENOG4105VR4 UPF0379 protein ybiJ HVX61_07195 ENOG4105KSC Transcriptional regulator, TraR DksA family HVX61_07205 ENOG4108IU3 tonb-dependent siderophore receptor HVX61_07210 ENOG4105ZY9 UPF0379 protein ybiM HVX61_07220 ENOG4105D8X mechanosensitive ion channel HVX61_07225 ENOG4105CDA abc transporter atp-binding protein HVX61_07230 ENOG4105E5Q amino acid AbC transporter HVX61_07235 ENOG4107R0W ABC transporter HVX61_07245 ENOG4107AQZ Membrane HVX61_07255 ENOG4108T1M outer membrane protein x HVX61_07260 ENOG4108I6E Sulfatase HVX61_07270 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HVX61_07305 ENOG4108IRC dna polymerase iii HVX61_07315 ENOG4105DFE Dna adenine methylase HVX61_07320 ENOG4105VZ1 Replication Protein HVX61_07330 ENOG4105ED4 portal protein HVX61_07425 ENOG4108X9F tail fiber protein HVX61_07430 ENOG4105UZW Tail fiber assembly protein HVX61_07460 ENOG4105KST dependent repressor HVX61_07465 ENOG4105F4P )-transporter HVX61_07470 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein HVX61_07475 ENOG4105C5H ABC transporter HVX61_07480 ENOG41072TH Protein of unknown function (DUF1479) HVX61_07485 ENOG4108HCJ Hydrolase HVX61_07495 ENOG4105F1A Pyruvate formate-lyase HVX61_07500 ENOG4107T9Z Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) HVX61_07505 ENOG4105D06 uba thif-type nad fad binding protein HVX61_07510 ENOG4105CVM Molybdenum cofactor synthesis domain protein HVX61_07515 ENOG4105D44 asparaginase HVX61_07520 ENOG4108JQ6 ABC transporter HVX61_07525 ENOG4105DEF Extracellular solute-binding protein, family 5 HVX61_07540 ENOG4105BZU Histidine kinase HVX61_07545 ENOG41064RH membrane protein YliF HVX61_07565 ENOG4105UFT Represses biofilm formation in M9C glu and LB glu media but not in M9C and LB media. Seems to act as a global regulator of several genes involved in catabolite repression and stress response and regulation of the uptake and export of signaling pathways. Could be involved the regulation of indole as well as uptake and export of AI-2 through a cAMP-dependent pathway HVX61_07570 ENOG4105D8V Glucose sorbosone dehydrogenase HVX61_07575 ENOG4108TGY Glutathione S-transferase HVX61_07580 ENOG4105DZ1 carboxypeptidase HVX61_07585 ENOG4107FB0 transcriptional regulator DeoR family HVX61_07590 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase HVX61_07595 ENOG4107QF7 multi-drug HVX61_07605 ENOG4108HCJ Hydrolase HVX61_07610 ENOG4106UW1 Major Facilitator superfamily HVX61_07615 ENOG4108RFG Tetr family transcriptional regulator HVX61_07625 ENOG4105GWF inner membrane protein YbjM HVX61_07630 ENOG41090BQ Glutaredoxin HVX61_07635 ENOG4105X20 member of the soxRS regulon which mediates in part the increased levels of superoxide in response to oxidative stress HVX61_07640 ENOG4108DBC nitroreductase HVX61_07650 ENOG4108RMJ sensory transduction regulator HVX61_07655 ENOG4107RUE extracellular solute-binding protein family 1 HVX61_07660 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HVX61_07665 ENOG4105F38 ABC transporter, permease HVX61_07670 ENOG4105D38 putrescine abc transporter HVX61_07675 ENOG4105RBQ inner membrane protein ybjO HVX61_07700 ENOG4106TNF Periplasmic binding protein HVX61_07705 ENOG4105DMR ABC, transporter HVX61_07710 ENOG4105GBT ABC transporter HVX61_07715 ENOG4106PMH Extracellular solute-binding protein family 3 HVX61_07720 ENOG4105E5Z arginine transporter ATP-binding subunit HVX61_07725 ENOG41064MM (LipO)protein HVX61_07740 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase HVX61_07745 ENOG4107VBM 3-beta hydroxysteroid dehydrogenase isomerase HVX61_07750 ENOG4105CGD Nad-dependent epimerase dehydratase HVX61_07755 ENOG4105C5W Aldolase HVX61_07760 ENOG4105C7K acetolactate synthase HVX61_07765 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) HVX61_07775 ENOG4105DWU Membrane HVX61_07780 ENOG4105EQR Transposase IS116 IS110 IS902 HVX61_07785 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) HVX61_07790 ENOG4105CPB ATP-dependent endonuclease of the OLD family HVX61_07795 ENOG4108MJ5 VirK protein HVX61_07800 ENOG4105DJY efflux transporter, rnd family, mfp subunit HVX61_07805 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) HVX61_07810 ENOG4105VEQ Cold shock protein HVX61_07820 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit HVX61_07835 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) HVX61_07845 ENOG4108JJ8 (ABC) transporter HVX61_07850 ENOG4108JJ9 ABC, transporter HVX61_07855 ENOG4105C3M thioredoxin reductase HVX61_07865 ENOG4105CNU cell division protein FtsK HVX61_07875 ENOG4105D1H recombination factor protein RarA HVX61_07885 ENOG4107QY8 reductase HVX61_07890 ENOG4105QAX Iron-sulfur HVX61_07895 ENOG4107KGK dmso reductase anchor subunit HVX61_07900 ENOG4105CHJ isochorismatase hydrolase HVX61_07910 ENOG4105E5D amino acid HVX61_07920 ENOG4105F1A Pyruvate formate-lyase HVX61_07925 ENOG4105C6N Formate acetyltransferase HVX61_07930 ENOG4105TMB Formate nitrite transporter HVX61_07935 ENOG4105DDY UPF0142 protein ycaO HVX61_07940 ENOG4107VMU Membrane HVX61_07955 ENOG4108K0D peptidase, M48 HVX61_07965 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) HVX61_07975 ENOG4108EQH DNA internalization-related competence protein ComEC Rec2 HVX61_07980 ENOG4105BZ1 (ABC) transporter HVX61_07990 ENOG4105T0Z Conserved Protein HVX61_08005 ENOG4107VR7 transferase activity, transferring phosphorus-containing groups HVX61_08010 ENOG4107S90 membrAne HVX61_08015 ENOG4106371 Methyltransferase HVX61_08025 ENOG4105DAH Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF (By similarity) HVX61_08035 ENOG4105DIT ErfK YbiS YcfS YnhG family protein HVX61_08040 ENOG4105EAQ (twin-arginine translocation) pathway signal HVX61_08045 ENOG4105C5X domain protein HVX61_08050 ENOG4105CGF Aromatic amino acid aminotransferase HVX61_08055 ENOG4105FCK Membrane HVX61_08070 ENOG4105CD8 aminopeptidase N HVX61_08075 ENOG4105E2Y ABC, transporter HVX61_08080 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component HVX61_08090 ENOG4105GVF (ABC) transporter HVX61_08095 ENOG4108UZX fmn reductase HVX61_08100 ENOG41071VI Part of the elfADCG-ycbUVF fimbrial operon, which promotes adhesion of bacteria to different abiotic surfaces. ElfA is the major fimbrial subunit produced by this operon HVX61_08105 ENOG4106JJN Part of the elfADCG-ycbUVF fimbrial operon, which promotes adhesion of bacteria to different abiotic surfaces. Could be required for the biogenesis of the ElfA fimbriae HVX61_08110 ENOG4105CW0 outer membrane usher protein HVX61_08115 ENOG4108MDY Fimbrial HVX61_08120 ENOG4105Q7J Fimbrial HVX61_08125 ENOG4105MX3 Fimbrial HVX61_08130 ENOG4106PH7 chaperone HVX61_08140 ENOG4108T7E Contributes to the efficiency of the cell division process by stabilizing the polymeric form of the cell division protein FtsZ. Acts by promoting interactions between FtsZ protofilaments and suppressing the GTPase activity of FtsZ (By similarity) HVX61_08145 ENOG4105QVC MOSC domain-containing protein HVX61_08155 ENOG4105C5H ABC transporter HVX61_08160 ENOG4105F1S paraquat-inducible protein a HVX61_08165 ENOG4105DY2 Paraquat-inducible protein b HVX61_08170 ENOG4108Q2G (LipO)protein HVX61_08175 ENOG4105WFT During stationary phase, converts 70S ribosomes to an inactive dimeric form (100S ribosomes) (By similarity) HVX61_08185 ENOG4105DAN ATP-dependent protease HVX61_08205 ENOG4108RZ1 DNA transformation protein HVX61_08210 ENOG4105EM2 membrane HVX61_08215 ENOG410901E Membrane HVX61_08220 ENOG41088T4 Helicase IV HVX61_08235 ENOG4105K4P CoA-binding domain protein HVX61_08250 ENOG4105VSY K01512 acylphosphatase EC 3.6.1.7 HVX61_08255 ENOG4108Z0T Part of a sulfur-relay system (By similarity) HVX61_08260 ENOG4108MN8 Membrane HVX61_08270 ENOG4105E3S small subunit HVX61_08275 ENOG4105DPX Hydrogenase, large subunit HVX61_08280 ENOG4105X7T Ni Fe-hydrogenase, b-type cytochrome subunit HVX61_08285 ENOG4108USZ hydrogenase HVX61_08290 ENOG4108VXY Hydrogenase-1 operon protein HyaE HVX61_08295 ENOG4105MVP hydrogenase-1 operon protein HyaF HVX61_08300 ENOG4105C4M (Ubiquinol oxidase) subunit I HVX61_08305 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii HVX61_08315 ENOG4105D6F Phosphatase HVX61_08320 ENOG4108F2G Chain length determinant protein HVX61_08325 ENOG4107ZF2 Phosphatase HVX61_08330 ENOG4105DAY polysaccharide export protein HVX61_08335 ENOG4105E3R (LipO)protein HVX61_08340 ENOG4108W78 Pfam:DUF1017 HVX61_08345 ENOG4108Y9B (LipO)protein HVX61_08355 ENOG41060EU Cold shock-like protein HVX61_08360 ENOG4105VEQ Cold shock protein HVX61_08375 ENOG4106H71 Overexpression increases levels of unsaturated fatty acids and suppresses both the temperature-sensitive fabA6 mutation and cold-sensitive secG null mutation HVX61_08380 ENOG4105HEE Binding Domain protein HVX61_08385 ENOG4105BZU Histidine kinase HVX61_08390 ENOG4108SV3 Tmao reductase system periplasmic protein tort HVX61_08395 ENOG4106WF9 DNA-binding transcriptional regulator TorR HVX61_08400 ENOG4105CUW cytochrome C-TYPE protein HVX61_08405 ENOG4108J2R molybdopterin oxidoreductase HVX61_08410 ENOG4108SBI Involved in the biogenesis of TorA. Acts on TorA before the insertion of the molybdenum cofactor and, as a result, probably favors a conformation of the apoenzyme that is competent for acquiring the cofactor (By similarity) HVX61_08430 ENOG4105D6F Phosphatase HVX61_08435 ENOG4105XH3 HVX61_08445 ENOG4105XF5 Escherichia coli IMT2125 genomic chromosome, IMT2125 HVX61_08450 ENOG4105C2W permease HVX61_08485 ENOG4108R86 Transcriptional regulator HVX61_08490 ENOG4105C26 Dehydrogenase HVX61_08495 ENOG4105CK7 Sodium proline symporter HVX61_08510 ENOG410650H (LipO)protein HVX61_08520 ENOG4105D5M phosphate starvation-inducible protein HVX61_08530 ENOG4105CND Glycosyl transferase, family 2 HVX61_08535 ENOG4107BJW polysaccharide deacetylase HVX61_08540 ENOG4108TUY outer membrane protein PgaA HVX61_08545 ENOG4105BZU Histidine kinase HVX61_08550 ENOG4105CXC rtn protein HVX61_08560 ENOG4108TC1 Transcriptional regulator HVX61_08565 ENOG4105CHR reductase HVX61_08570 ENOG4108MQF Chaperone HVX61_08580 ENOG4105CW0 outer membrane usher protein HVX61_08585 ENOG4108AF8 Chaperone HVX61_08590 ENOG4105X0I Fimbrial HVX61_08600 ENOG4105CKT filamentous hemagglutinin HVX61_08605 ENOG4105D5K Hemolysin activator protein HVX61_08610 ENOG41081XD Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) HVX61_08620 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) HVX61_08630 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) HVX61_08635 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) HVX61_08680 ENOG4108T85 Membrane HVX61_08690 ENOG4105JPG D-isomer specific 2-hydroxyacid dehydrogenase HVX61_08700 ENOG4107XHZ cytoplasmic chaperone TorD family protein HVX61_08705 ENOG4108UQ5 membrane protein YcdZ HVX61_08710 ENOG4105P8Q Curli production assembly transport component CsgG HVX61_08715 ENOG4108WYR Curli production assembly transport component, CsgF HVX61_08720 ENOG4108XDW curli assembly protein CsgE HVX61_08725 ENOG41086KC Transcriptional regulator HVX61_08730 ENOG4108U0V Curli are coiled surface structures that assemble preferentially at growth temperatures below 37 degrees Celsius. Curli can bind to fibronectin. The minor subunit is the nucleation component of curlin monomers HVX61_08735 ENOG41090QH cryptic curlin major subunit HVX61_08750 ENOG4108UVJ appr-1-p processing domain protein HVX61_08755 ENOG4107RZC phospholipase d HVX61_08770 ENOG4105C3A Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs) (By similarity) HVX61_08775 ENOG4105NAC (LipO)protein HVX61_08780 ENOG4108W47 Acidic protein msyB HVX61_08790 ENOG4105D1S lipid A biosynthesis HVX61_08800 ENOG4108YYC ycei family HVX61_08805 ENOG4105DS1 cytochrome b561 HVX61_08810 ENOG4106974 biofilm formation HVX61_08820 ENOG4105PVA Biofilm formation regulatory protein BssS HVX61_08825 ENOG4105MEA DNA damage-inducible protein i HVX61_08835 ENOG4105F3T (LipO)protein HVX61_08840 ENOG4105E9S glutaredoxin 2 HVX61_08850 ENOG4105D9U N-acetyltransferase HVX61_08860 ENOG4105EP9 oxidoreductase HVX61_08865 ENOG4105CJR Integral membrane protein (MviN HVX61_08870 ENOG4105QVD Flagella synthesis protein FlgN HVX61_08875 ENOG4105M9M anti-sigma28 factor FlgM HVX61_08880 ENOG4105CKS Flagella basal body P-ring formation protein flgA HVX61_08885 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) HVX61_08890 ENOG4108ZC9 flagellar basal-body rod protein flgc HVX61_08895 ENOG4105W00 Flagellar hook capping protein HVX61_08900 ENOG4105BZE flagellar hook protein, FlgE HVX61_08905 ENOG4108KPB Flagellar basal-body rod protein FlgF HVX61_08910 ENOG4105CGA flagellar basal-body rod protein FlgG HVX61_08925 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj HVX61_08930 ENOG4105E1Q flagellar hook-associated protein HVX61_08935 ENOG4105DTJ flagellar hook-associated protein HVX61_08940 ENOG4107QQB Ribonuclease E HVX61_08945 ENOG4105EI2 Pseudouridine synthase HVX61_08950 ENOG4108UHJ MAF-like protein HVX61_08955 ENOG4105FCQ metal-binding, possibly nucleic acid-binding protein HVX61_08975 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase HVX61_08980 ENOG4105CHR reductase HVX61_08985 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) HVX61_08990 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) HVX61_08995 ENOG4105YAZ 4-amino-4-deoxychorismate lyase HVX61_09000 ENOG4105HHA aminodeoxychorismate lyase HVX61_09010 ENOG4107QRG dna polymerase iii HVX61_09015 ENOG4105F8V Hydrolase, tatD family HVX61_09020 ENOG4105CI1 PTS System HVX61_09025 ENOG4105CNM Receptor HVX61_09030 ENOG4105K59 histidine triad (HIT) protein HVX61_09035 ENOG41090DQ Lipoprotein HVX61_09040 ENOG4108WEF Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b) (By similarity) HVX61_09045 ENOG4108RUM thiamine kinase HVX61_09060 ENOG4105CEP NADH dehydrogenase HVX61_09065 ENOG4107MBR 17 kDa surface antigen HVX61_09070 ENOG4108IND Tetr family transcriptional regulator HVX61_09075 ENOG4105RC8 Reduces the permeability of the outer membrane to copper. Seems to be involved in the regulation of biofilm formation. May decrease biofilm formation by repressing cell-cell interaction and cell surface interaction HVX61_09080 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein HVX61_09085 ENOG4108JA2 transcriptioN-repair coupling factor HVX61_09090 ENOG4105IQC Inner membrane protein YcfT HVX61_09095 ENOG4105D60 lipoprotein releasing system transmembrane protein HVX61_09100 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) HVX61_09105 ENOG4105D60 lipoprotein releasing system transmembrane protein HVX61_09115 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) HVX61_09120 ENOG4107RUE extracellular solute-binding protein family 1 HVX61_09125 ENOG4105D38 putrescine abc transporter HVX61_09140 ENOG4108I1J Integrase HVX61_09155 ENOG4106G8A Qin prophage HVX61_09260 ENOG4108MXB Protein of unknown function (DUF968) HVX61_09265 ENOG4105KSK (crossover) junction endodeoxyribonuclease HVX61_09270 ENOG4105HRS Antitermination protein HVX61_09300 ENOG4105QYK bacteriophage lambda Bor protein homolog HVX61_09320 ENOG4105UZW Tail fiber assembly protein HVX61_09325 ENOG4107DE1 head-to-tail joining protein HVX61_09410 ENOG4105IM0 capsid protein HVX61_09450 ENOG4105IM0 capsid protein HVX61_09525 ENOG4108X9F tail fiber protein HVX61_09530 ENOG4105UZW Tail fiber assembly protein HVX61_09540 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HVX61_09550 ENOG4105EZE Cupin 4 family protein HVX61_09555 ENOG4105IFJ Histidine kinase HVX61_09560 ENOG4105XJC Two component transcriptional regulator (Winged helix family HVX61_09565 ENOG4107QTF adenylosuccinate lyase HVX61_09585 ENOG4108R99 pseudouridine synthase HVX61_09590 ENOG4108HMX isocitrate dehydrogenase (NADP) HVX61_09615 ENOG41064WM Uncharacterized protein YcgX HVX61_09620 ENOG4108XDN Transcriptional regulator HVX61_09625 ENOG4105BZU Histidine kinase HVX61_09630 ENOG4105WKE Probably a connector protein for RcsB C regulation of biofilm formation, providing additional signal input into the two- component signaling pathway. Partially antagonizes the activities of YmgA and AriR, proteins that, via the Rcs phosphorelay, promote the synthesis of colanic acid, an exopolysaccharide and matrix component HVX61_09635 ENOG41077SS Probably a connector protein for RcsB C regulation of biofilm formation, providing additional signal input into the two- component signaling pathway. May serve to stimulate biofilm maturation, probably via the Rcs phosphorelay. Mild overexpression at 16 degrees Celsius increases the production of colanic acid, an exopolysaccharide and matrix component, and reduces adhesive curli fimbriae expression. Both of these effects require RcsB HVX61_09645 ENOG410738I uncharacterized protein ymgC HVX61_09650 ENOG4105BZU Histidine kinase HVX61_09665 ENOG410658X HVX61_09700 ENOG4107QMS site-determining protein HVX61_09710 ENOG4105S66 prophage protein HVX61_09715 ENOG41066UD Inhibits activity of g-type lysozyme, which confers increased lysozyme tolerance to the bacterium HVX61_09725 ENOG4105FBJ fumarylacetoacetate (faa) hydrolase HVX61_09735 ENOG4106PXS Toxin, which has some hemolytic activity towards mammalian cells. Acts by forming a pore-like structure upon contact with mammalian cells HVX61_09740 ENOG4105KT5 UmuD protein HVX61_09745 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) HVX61_09750 ENOG410635M Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein (By similarity) HVX61_09775 ENOG4105ED1 spovr family HVX61_09785 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) HVX61_09805 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A HVX61_09815 ENOG4108T7K Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Increasing levels of c-di-GMP lead to decreased motility (By similarity) HVX61_09830 ENOG4108PQF modD protein HVX61_09835 ENOG4108BSC Methyltransferase HVX61_09840 ENOG4105E0A ABC, transporter HVX61_09845 ENOG4105EHG Permease protein HVX61_09850 ENOG4105S10 periplasmic binding protein HVX61_09860 ENOG4105VDH Dihydroxyacetone kinase HVX61_09865 ENOG4108UTZ Dihydroxyacetone kinase HVX61_09870 ENOG4105CMT Dihydroxyacetone kinase HVX61_09875 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family HVX61_09880 ENOG4105I1J Autotransporter HVX61_09885 ENOG4105C3G gtp-binding protein HVX61_09895 ENOG4105MGX transcription activated by CRP (cyclic AMP receptor protein), a global transcription factor involved in regulation of metabolism in enteric bacteria HVX61_09900 ENOG4105CHH sulfate transporter HVX61_09905 ENOG4105C5T Phosphoribosyl pyrophosphate synthase HVX61_09910 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) HVX61_09930 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) HVX61_09935 ENOG4108YY7 Invasion gene expression up-regulator SirB HVX61_09940 ENOG41063JG Transcriptional regulator HVX61_09960 ENOG4105EWV Sodium calcium exchanger membrane region HVX61_09965 ENOG4105WS7 Cation transport regulator HVX61_09970 ENOG4108NH8 Cation transport protein HVX61_09975 ENOG41090EX DsrE family HVX61_09980 ENOG4105ID0 Putative invasin HVX61_09985 ENOG4105WH1 Two component transcriptional regulator luxr family HVX61_09990 ENOG4105BZU Histidine kinase HVX61_09995 ENOG4105DQQ Major facilitator superfamily MFS_1 HVX61_10000 ENOG4105CRU nitrate reductase, alpha subunit HVX61_10005 ENOG4108IUE nitrate reductase beta subunit HVX61_10010 ENOG4105R3A Nitrate reductase HVX61_10015 ENOG41076YT nitrate reductase, gamma subunit HVX61_10035 ENOG4105CIY formyltetrahydrofolate deformylase HVX61_10045 ENOG4105D78 K07001 NTE family protein HVX61_10050 ENOG4105I93 response regulator HVX61_10055 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase HVX61_10065 ENOG4108SAU DNA-binding protein H-ns HVX61_10070 ENOG4107104 thymidine kinase HVX61_10075 ENOG4105C0A alcohol dehydrogenase HVX61_10080 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein HVX61_10090 ENOG4108J59 Extracellular solute-binding protein, family 5 HVX61_10095 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HVX61_10100 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HVX61_10105 ENOG4105C3U ABC transporter HVX61_10110 ENOG4108JQ7 (ABC) transporter HVX61_10130 ENOG4107SVH Potassium channel protein HVX61_10135 ENOG4105K9H YciI-like protein HVX61_10140 ENOG410822N TonB family HVX61_10145 ENOG4105NAU thioesterase Superfamily protein HVX61_10165 ENOG4105EIF outer membrane protein W HVX61_10170 ENOG4108N8X transition metal ion binding HVX61_10175 ENOG4108Z9Z response to DNA damage stimulus HVX61_10185 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) HVX61_10195 ENOG4105DK0 Indole-3-glycerol phosphate synthase HVX61_10200 ENOG4108EFP Anthranilate synthase component II HVX61_10205 ENOG4105CRQ synthase (Component I) HVX61_10215 ENOG4105DB7 PHP domain protein HVX61_10220 ENOG4107RTD sua5 ycio yrdc ywlc family protein HVX61_10225 ENOG4105EG3 transmembrane signal peptide protein HVX61_10230 ENOG4105FE9 pseudouridine synthase HVX61_10235 ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase HVX61_10240 ENOG4105UBK short-chain dehydrogenase reductase HVX61_10245 ENOG4105ERU peptidase HVX61_10255 ENOG4105RKX Protein of unknown function (DUF2498) HVX61_10260 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) HVX61_10265 ENOG4107R11 Transcriptional regulator HVX61_10285 ENOG4107QM5 aconitate hydratase HVX61_10295 ENOG4105EYK Phosphatidylglycerophosphatase B HVX61_10300 ENOG4105Q4A inner membrane protein yciS HVX61_10305 ENOG4105CFV Tetratricopeptide repeat protein HVX61_10315 ENOG4108ZJT translation initiation factor, Sui1 HVX61_10325 ENOG4105N2W Transcriptional regulator HVX61_10330 ENOG410643D UPF0509 protein HVX61_10335 ENOG4105BZU Histidine kinase HVX61_10355 ENOG4105Q4T oxidoreductase HVX61_10360 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH HVX61_10365 ENOG41067SE Tetr family transcriptional regulator HVX61_10370 ENOG4105C1P efflux transporter, rnd family, mfp subunit HVX61_10375 ENOG4105BZS acriflavin resistance protein HVX61_10380 ENOG4105ENJ RND efflux system, outer membrane lipoprotein HVX61_10385 ENOG4105C2C drug resistance transporter, Bcr CflA HVX61_10390 ENOG4108JQ2 peptide transport system atp-binding protein HVX61_10395 ENOG4108JQ3 Peptide ABC transporter ATP-binding protein HVX61_10400 ENOG4108EU3 peptide transport system, permease HVX61_10405 ENOG4108I5W peptide transport system, permease protein HVX61_10410 ENOG4108HIY periplasmic HVX61_10415 ENOG4105N0E Protein of unknown function (DUF2543) HVX61_10420 ENOG4105CUB amino acid HVX61_10430 ENOG4105CFQ glutamine synthetase HVX61_10435 ENOG4108Z86 Glutamine amidotransferase HVX61_10440 ENOG4107VRI Transcriptional regulator HVX61_10445 ENOG4105C26 Dehydrogenase HVX61_10450 ENOG4105CJP fad dependent oxidoreductase HVX61_10455 ENOG4108JPW Aminotransferase HVX61_10460 ENOG4105E51 psp operon transcriptional activator HVX61_10465 ENOG41087YS Phage shock protein A HVX61_10470 ENOG4105YYT phage shock protein B HVX61_10475 ENOG4105FM1 phage shock protein C HVX61_10480 ENOG4105NNG Peripheral inner membrane phage-shock protein HVX61_10485 ENOG4105K8Z Phage shock protein HVX61_10490 ENOG4105CM6 amino acid regulated cytosolic protein HVX61_10500 ENOG4108JU8 Transcriptional regulator HVX61_10505 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) HVX61_10510 ENOG4107S8C mandelate racemase muconate lactonizing HVX61_10515 ENOG4105KXI murein peptide amidase A HVX61_10535 ENOG4105ENX hydrolase HVX61_10540 ENOG4105EQ2 LysR family Transcriptional regulator HVX61_10545 ENOG4107QSI ABC, transporter HVX61_10550 ENOG4105D64 Mechanosensitive ion channel HVX61_10555 ENOG4105S5I Membrane HVX61_10560 ENOG4105Q9Y Universal stress protein HVX61_10565 ENOG4105DS0 Transcriptional regulator, Crp Fnr family HVX61_10570 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) HVX61_10580 ENOG4105R1U AraC Family Transcriptional Regulator HVX61_10595 ENOG4108DG9 Smr protein MutS2 HVX61_10600 ENOG4105BZU Histidine kinase HVX61_10610 ENOG4105C1J atp-dependent rna helicase HVX61_10620 ENOG4108RW8 Universal stress protein F HVX61_10625 ENOG4105FCK Membrane HVX61_10635 ENOG4105D95 Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity) HVX61_10640 ENOG4105IKK cytoplasmic protein HVX61_10645 ENOG41090X5 Heat shock protein hslJ HVX61_10650 ENOG4105C5I Dehydrogenase HVX61_10655 ENOG4107H52 Dicarboxylate transport HVX61_10660 ENOG410689M (LipO)protein HVX61_10665 ENOG4105WXT Conserved Protein HVX61_10670 ENOG4108WFR AraC Family Transcriptional Regulator HVX61_10675 ENOG4105C26 Dehydrogenase HVX61_10680 ENOG4105F11 amine oxidase HVX61_10685 ENOG4105DXM phenylacetic acid degradation protein HVX61_10690 ENOG4105CRS phenylacetate-CoA oxygenase PaaG subunit HVX61_10695 ENOG4105N76 Phenylacetate-CoA oxygenase, subunit HVX61_10700 ENOG4105D9S phenylacetate-CoA oxygenase PaaI subunit HVX61_10705 ENOG4108ZA2 phenylacetate-CoA oxygenase PaaJ subunit HVX61_10710 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) HVX61_10715 ENOG4105E39 Enoyl-CoA hydratase HVX61_10720 ENOG4108UKI Enoyl-CoA hydratase HVX61_10725 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase HVX61_10730 ENOG4108ZJI phenylacetic acid degradation protein HVX61_10735 ENOG4105CHU acetyl-coa acetyltransferase HVX61_10740 ENOG4105DZS Phenylacetate-CoA ligase HVX61_10745 ENOG4105V9J phenylacetic acid degradation operon negative regulatory protein HVX61_10750 ENOG4108Z0R Transferase HVX61_10755 ENOG4107S5I aldo keto reductase HVX61_10765 ENOG4108UMZ Cdp-alcohol phosphatidyltransferase HVX61_10770 ENOG4108HPI phosphatidate Cytidylyltransferase HVX61_10775 ENOG4105E8V Alpha Beta Hydrolase Fold protein HVX61_10780 ENOG41077RS Phosphatase HVX61_10790 ENOG4105CQ7 ATP-dependent helicase HVX61_10795 ENOG4107DB1 DUF218 domain HVX61_10800 ENOG4105C26 Dehydrogenase HVX61_10805 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase HVX61_10810 ENOG4105CPW cytochrome b561 HVX61_10815 ENOG4105UPP uncharacterized protein ydcA HVX61_10820 ENOG4107NK6 Hok/gef family HVX61_10825 ENOG4105C8Q Methyl-accepting chemotaxis HVX61_10830 ENOG4105DDW LysR family Transcriptional regulator HVX61_10835 ENOG4105E32 cytoplasmic protein HVX61_10845 ENOG4105Z2P Protein of unknown function (DUF465) HVX61_10850 ENOG4108Z9I -acetyltransferase HVX61_10855 ENOG4107WE3 acetyltransferase YdcK HVX61_10860 ENOG4108NKP c4-dicarboxylate transporter malic acid transport protein HVX61_10865 ENOG41088CC tellurite resistance protein tehB HVX61_10870 ENOG4108KKZ (LipO)protein HVX61_10880 ENOG4105D7V transposase HVX61_10885 ENOG4105DKK Benzoate HVX61_10890 ENOG4108JCI Transcriptional regulator HVX61_10895 ENOG4105CFP Peptidase U32 HVX61_10900 ENOG4105RR0 Protein of unknown function (DUF2554) HVX61_10910 ENOG4105PF0 Antitoxin component of a toxin-antitoxin (TA) module. Functions as an mRNA interferase antitoxin HVX61_10915 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HVX61_10920 ENOG4107TYH extracellular solute-binding protein family 1 HVX61_10925 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HVX61_10930 ENOG4105D81 ABC transporter, permease HVX61_10935 ENOG4105NRK Binding-protein-dependent transport systems, inner membrane component HVX61_10950 ENOG410654E Membrane HVX61_10955 ENOG4105R71 cytoplasmic protein HVX61_10960 ENOG4108T9Y Inner membrane protein ydcZ HVX61_10965 ENOG4108Z7F N-acetyltransferase HVX61_10970 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein HVX61_10975 ENOG4108WYP Transcriptional regulator HVX61_10980 ENOG4105CHB tonB-dependent Receptor HVX61_10985 ENOG4108NS2 receptor HVX61_10990 ENOG4105C85 amino acid HVX61_10995 ENOG4108N27 Glutathione S-transferase HVX61_11045 ENOG4108MEJ flavin reductase domain protein HVX61_11050 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase HVX61_11055 ENOG4105JAB phenazine biosynthesis protein, phzf family HVX61_11060 ENOG4105D0D Nitrate reductase 2, gamma subunit HVX61_11065 ENOG4108NZN Respiratory nitrate reductase 2 delta chain HVX61_11070 ENOG4108IUE nitrate reductase beta subunit HVX61_11075 ENOG4105CRU nitrate reductase, alpha subunit HVX61_11080 ENOG4107QND Nitrite extrusion protein HVX61_11085 ENOG4108UI3 Leucine Rich repeat HVX61_11090 ENOG4108UI3 Leucine Rich repeat HVX61_11100 ENOG4105RPH Inner membrane protein YddG HVX61_11110 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein HVX61_11115 ENOG4108MG3 formate dehydrogenase HVX61_11120 ENOG41084S7 Plasmid maintenance system antidote protein HVX61_11125 ENOG4105DQ4 alcohol dehydrogenase HVX61_11135 ENOG4107AV5 Although this protein associates with the 30S subunit of the ribosome it is not considered to be a bona fide ribosomal protein HVX61_11140 ENOG4105TPS biofilm-dependent modulation protein HVX61_11145 ENOG4108Z9K Osmotically inducible protein HVX61_11150 ENOG4107H6U ABC transporter HVX61_11155 ENOG4105C3U ABC transporter HVX61_11160 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HVX61_11165 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HVX61_11170 ENOG4105DEF Extracellular solute-binding protein, family 5 HVX61_11175 ENOG4108UQS dipeptidase HVX61_11180 ENOG4105BZU Histidine kinase HVX61_11185 ENOG4105BZU Histidine kinase HVX61_11195 ENOG4105F32 YngK protein HVX61_11200 ENOG4105E5D amino acid HVX61_11205 ENOG4105CVK Glutamate decarboxylase HVX61_11210 ENOG4107RAN Peptidase, M16 HVX61_11215 ENOG4105PE1 Receptor HVX61_11220 ENOG4105CQ0 ABC transporter HVX61_11230 ENOG4105C4X radical SAM domain protein HVX61_11235 ENOG4105ENH Sulfatase HVX61_11250 ENOG4107QKC Oxidoreductase alpha (molybdopterin) subunit HVX61_11255 ENOG4106PIH fimbrial-like protein ydeQ HVX61_11260 ENOG4106318 fimbrial-like protein YdeR HVX61_11265 ENOG4108WDE Fimbrial protein HVX61_11270 ENOG4105CW0 outer membrane usher protein HVX61_11280 ENOG4108RQP Major type 1 subunit fimbrin HVX61_11290 ENOG4105CAF HipA N-terminal domain protein HVX61_11295 ENOG41061P8 Persistence to inhibition of murein or DNA biosynthesis regulatory protein HVX61_11310 ENOG4107RYS Autoinducer-2 (AI-2) kinase HVX61_11320 ENOG4105C2J ABC transporter HVX61_11325 ENOG41071MT Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane HVX61_11340 ENOG41061GT Aldolase HVX61_11345 ENOG4105K34 Involved in the degradation of phospho-AI-2, thereby terminating induction of the lsr operon and closing the AI-2 signaling cycle. Catalyzes the cleavage of phosphorylated 4,5- dihydroxy-2,3-pentanedione (P-DPD) to 2-phosphoglycolic acid (PG) and another three-carbon compound HVX61_11355 ENOG4105D7V transposase HVX61_11360 ENOG4107R6G Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate (By similarity) HVX61_11365 ENOG4105FFC UPF0187 protein HVX61_11375 ENOG4105BZU Histidine kinase HVX61_11380 ENOG4105M0C cytoplasmic protein HVX61_11385 ENOG4105CSV Glutaminase HVX61_11390 ENOG4105C26 Dehydrogenase HVX61_11395 ENOG4105EGI Transcriptional regulator HVX61_11415 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes HVX61_11420 ENOG4108XW0 May be a transcriptional activator of genes involved in the multiple antibiotic resistance (Mar) phenotype. It can also activate genes such as sodA, zwf and micF HVX61_11425 ENOG4106DNR multiple antibiotic resistance protein HVX61_11430 ENOG4108594 Permease of the drug metabolite transporter HVX61_11435 ENOG4105E5W Transporter HVX61_11445 ENOG4105FSR swimming returnes to normal when residues 206-207 are both mutated to Ala. Overexpression also leads to a reduction in flagellar abundance and a 20-fold increase in c-di- GMP levels in vivo. Required for aminoglycoside-mediated induction of biofilm formation, it also plays a lesser role in biofilm production in response to other classes of translation inhibitors. The c-di-GMP produced by this enzyme up-regulates poly-GlcNAc production as well as the biofilm synthesis protein PgaD, although c-di-GMP is probably not the main inducing principle. Cyclic-di- GMP is a second messenger which controls cell surface-associated traits in bacteria HVX61_11450 ENOG4108YDI single-species biofilm formation on inanimate substrate HVX61_11455 ENOG4108WTK competence damage-inducible protein HVX61_11460 ENOG4105DGW oligopeptidase A HVX61_11465 ENOG4105EMU Dehydrogenase HVX61_11470 ENOG4107XBN GntR Family Transcriptional Regulator HVX61_11475 ENOG41061EV selenium-binding protein YdfZ HVX61_11480 ENOG4105DEI Mannitol dehydrogenase HVX61_11495 ENOG4105W3V DNA-binding, transcriptional regulator HVX61_11500 ENOG4105MN3 Resolvase HVX61_11505 ENOG4105UZW Tail fiber assembly protein HVX61_11510 ENOG410685N tail fiber protein HVX61_11585 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) HVX61_11610 ENOG4106YSC HVX61_11615 ENOG41064WM Uncharacterized protein YcgX HVX61_11620 ENOG4106H71 Overexpression increases levels of unsaturated fatty acids and suppresses both the temperature-sensitive fabA6 mutation and cold-sensitive secG null mutation HVX61_11625 ENOG4106IAW HVX61_11640 ENOG4105VEQ Cold shock protein HVX61_11645 ENOG4108YV9 Protein of unknown function (DUF2514) HVX61_11660 ENOG4105QFS Lysis protein S homolog from lambdoid prophage HVX61_11665 ENOG4105VEQ Cold shock protein HVX61_11680 ENOG4105HGD Antitermination protein HVX61_11685 ENOG4108MXB Protein of unknown function (DUF968) HVX61_11705 ENOG4105K4U addiction module toxin, RelE StbE family HVX61_11760 ENOG41087BU transcriptional repressor DicA HVX61_11780 ENOG4106G8A Qin prophage HVX61_11795 ENOG4107R08 Integrase HVX61_11805 ENOG4105CPQ Dehydrogenase HVX61_11810 ENOG4105CXK mandelate racemase muconate lactonizing HVX61_11825 ENOG4108MK9 spermidine N(1)-acetyltransferase HVX61_11835 ENOG4105KBG Protein of unknown function (DUF1161) HVX61_11840 ENOG4107QY8 reductase HVX61_11845 ENOG4105C3J Cysteine desulfurase HVX61_11850 ENOG4105QAX Iron-sulfur HVX61_11855 ENOG4107KGK dmso reductase anchor subunit HVX61_11860 ENOG4108NEM leader-binding protein dmsD HVX61_11870 ENOG4105EWW Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) HVX61_11875 ENOG4105DAG ROK family HVX61_11880 ENOG4106NZI LysR family Transcriptional regulator HVX61_11885 ENOG4105D94 Major Facilitator Superfamily HVX61_11900 ENOG4105CVW peptidase s1 and s6 chymotrypsin hap HVX61_11915 ENOG4105DSF transport protein HVX61_11920 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) HVX61_11925 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) HVX61_11930 ENOG4105C5D exported protein HVX61_11935 ENOG4105D5Q Arginine ornithine antiporter HVX61_11945 ENOG4105RA2 Membrane HVX61_11950 ENOG4107EXC regulatoR HVX61_11955 ENOG4105JJR Histidine kinase HVX61_11965 ENOG4105C9Q fumarate hydratase class II HVX61_11970 ENOG4107GFK fumarate HVX61_11975 ENOG4105EIP mannose-6-phosphate isomerase HVX61_11980 ENOG4106J39 exported protein HVX61_11985 ENOG4108QNI outer membrane porin protein HVX61_11990 ENOG4105CT4 transporter HVX61_11995 ENOG4105CNT hydrolase family 2 HVX61_12000 ENOG4105XEA Tetr family transcriptional regulator HVX61_12005 ENOG4107ZQV short-chain dehydrogenase reductase HVX61_12010 ENOG4107P2S Transcriptional regulator HVX61_12015 ENOG4105CI1 PTS System HVX61_12020 ENOG4105C87 Aminotransferase class I and II HVX61_12030 ENOG4105D9R oxidoreductase HVX61_12035 ENOG4106C6R beta-lactam resistance protein HVX61_12040 ENOG4105QZ5 OriC-binding nucleoid-associated protein HVX61_12045 ENOG4105M9B inner membrane protein ydgK HVX61_12070 ENOG4108UQQ Electron transport complex HVX61_12080 ENOG4105CSM endonuclease III HVX61_12085 ENOG4105DUX Transporter HVX61_12090 ENOG4108K3A Glutathione S-transferase HVX61_12095 ENOG4107XGF functions in a salvage pathway. Uses pyridoxamine (By similarity) HVX61_12110 ENOG410642K Lysozyme inhibitor HVX61_12120 ENOG4108XTF Outer Membrane Lipoprotein HVX61_12135 ENOG4105Y49 secretion protein, HlyD family HVX61_12140 ENOG4105DSW Fusaric acid resistance protein HVX61_12145 ENOG4108Z7T Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) HVX61_12150 ENOG4107RGM aldo keto reductase HVX61_12155 ENOG4105XZD Fe-S protein HVX61_12160 ENOG4108WUH Transcriptional regulator, TetR family HVX61_12165 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HVX61_12170 ENOG4108UYE Lactoylglutathione lyase HVX61_12180 ENOG4107QRT dEAD DEAH box helicase HVX61_12185 ENOG4105M2J Glutaredoxin HVX61_12190 ENOG4105K4H Nlp p60 protein HVX61_12195 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) HVX61_12200 ENOG4105F27 Major Facilitator HVX61_12215 ENOG4105F52 Transcriptional regulator HVX61_12220 ENOG4105CZQ inner membrane transport protein YdhC HVX61_12225 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase HVX61_12230 ENOG4108R6K riboflavin synthase, subunit alpha HVX61_12235 ENOG4107QI1 Mate efflux family protein HVX61_12255 ENOG4105N0V mono-oxygenase ydhR HVX61_12260 ENOG4108KTU conserved protein with FAD NAD(P)-binding domain HVX61_12265 ENOG4108Y7C Conserved Protein HVX61_12270 ENOG4108NWD Cytochrome HVX61_12275 ENOG4108393 oxidoreductase Fe-S subunit HVX61_12280 ENOG4105JVW HVX61_12285 ENOG4105WE2 aldehyde ferredoxin oxidoreductase HVX61_12290 ENOG4108PU5 4fe-4S ferredoxin, iron-sulfur binding domain protein HVX61_12295 ENOG4105RFR Protein of unknown function (DUF2767) HVX61_12300 ENOG4105CA9 Pyruvate kinase HVX61_12305 ENOG4105KMX major outer membrane lipoprotein HVX61_12310 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein HVX61_12325 ENOG4105JRK feS assembly protein SufD HVX61_12330 ENOG4105C3K feS assembly ATPase SufC HVX61_12335 ENOG4105DIW FeS assembly protein SUFB HVX61_12340 ENOG4108Z4V iron-sulfur cluster assembly HVX61_12345 ENOG410671Z uncharacterized protein ydiH HVX61_12350 ENOG4105KA0 thioesterase Superfamily protein HVX61_12355 ENOG4105CQB FAD linked oxidase domain protein HVX61_12360 ENOG4105IPI Membrane HVX61_12370 ENOG4105SUA Ydil protein HVX61_12375 ENOG4105EMV Major Facilitator HVX61_12380 ENOG4105EMV Major Facilitator HVX61_12395 ENOG4108IIG CoA transferase having broad substrate specificity for short-chain acyl-CoA thioesters with the activity decreasing when the length of the carboxylic acid chain exceeds four carbons (By similarity) HVX61_12400 ENOG4105C1G acyl-Coa dehydrogenase HVX61_12405 ENOG4105W4W Transcriptional regulator HVX61_12410 ENOG4105CV7 Electron transfer flavoprotein HVX61_12415 ENOG4105C10 Electron transfer flavoprotein HVX61_12420 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase HVX61_12425 ENOG41090P5 ferredoxin-like protein HVX61_12430 ENOG4105CEY Amp-dependent synthetase and ligase HVX61_12435 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) HVX61_12445 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) HVX61_12460 ENOG4108TC0 Diguanylate phosphodiesterase HVX61_12465 ENOG4108QBX (LipO)protein HVX61_12475 ENOG4108V06 Glutathione peroxidase HVX61_12490 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) HVX61_12510 ENOG41082NX 50s ribosomal protein l35 HVX61_12515 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) HVX61_12535 ENOG4108NE3 Salt-induced outer membrane protein HVX61_12540 ENOG4105DE4 1-phosphofructokinase HVX61_12545 ENOG4105P10 Uncharacterized protein ydiZ HVX61_12555 ENOG4107PN8 YfeABCD locus regulator HVX61_12560 ENOG4107UW8 HAD-superfamily hydrolase subfamily IA variant 3 HVX61_12565 ENOG4107K5X Membrane-bound metal-dependent hydrolase HVX61_12570 ENOG4108ETY sodium dicarboxylate symporter HVX61_12585 ENOG4105CH6 catalase HVX61_12595 ENOG4105F8D glycoside hydrolase family 4 HVX61_12600 ENOG4105EZV Transcriptional regulator HVX61_12605 ENOG4105VCP PTS System HVX61_12610 ENOG4105CK1 PTS System HVX61_12615 ENOG4105VZJ PTS System HVX61_12620 ENOG4105KKI DNA-binding transcriptional activator OsmE HVX61_12625 ENOG4107RA1 nh(3)-dependent nad( ) synthetase HVX61_12630 ENOG4105DKD Incises the DNA at the 3' side of a lesion during nucleotide excision repair. Incises the DNA farther away from the lesion than UvrC. Not able to incise the 5' site of a lesion. When a lesion remains because UvrC is not able to induce the 3' incision, Cho incises the DNA. Then UvrC makes the 5' incision. The combined action of Cho and UvrC broadens the substrate range of nucleotide excision repair (By similarity) HVX61_12640 ENOG4108SPG Periplasmic Protein HVX61_12650 ENOG4105EY2 Catalyzes the hydrolysis of N(2)-succinylarginine into N(2)-succinylornithine, ammonia and CO(2) (By similarity) HVX61_12655 ENOG4105C26 Dehydrogenase HVX61_12670 ENOG4105CGK Exodeoxyribonuclease III HVX61_12675 ENOG4108RSN SNARE associated Golgi HVX61_12680 ENOG4108KCW iron-sulfur cluster binding HVX61_12685 ENOG4108N5C SNARE associated Golgi protein-related protein HVX61_12690 ENOG4107ZN8 Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) HVX61_12695 ENOG4105VNH ABC transporter solute-binding protein HVX61_12700 ENOG4105CXZ ABC transporter, permease HVX61_12705 ENOG4108VGW abc transporter atp-binding protein HVX61_12710 ENOG4107RM6 sulfurtransferase HVX61_12715 ENOG4108T9J Cdp-alcohol phosphatidyltransferase HVX61_12720 ENOG4105M6F mutator MutT protein HVX61_12725 ENOG4105MTM Protein of unknown function (DUF1496) HVX61_12730 ENOG4105D82 Glutamate dehydrogenase HVX61_12735 ENOG41065FB inner membrane protein ynji HVX61_12740 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) HVX61_12745 ENOG4105D4F Synthesizes selenophosphate from selenide and ATP (By similarity) HVX61_12750 ENOG41069NU Nitroreductase HVX61_12755 ENOG4105D07 Signal peptide peptidase, SppA HVX61_12760 ENOG4105HDK L-asparaginase HVX61_12765 ENOG4108RWI nicotinamidase HVX61_12770 ENOG4108KUU Inner membrane metabolite transport protein ydjE HVX61_12775 ENOG4105E98 transcriptional regulator DeoR family HVX61_12780 ENOG4105CPC Aldo Keto reductase HVX61_12785 ENOG4107UH8 sugar kinase HVX61_12790 ENOG4105D2N Aldolase HVX61_12795 ENOG4105CPQ Dehydrogenase HVX61_12800 ENOG4107TE1 transport protein HVX61_12805 ENOG4105CPQ Dehydrogenase HVX61_12810 ENOG4105VUT cytoplasmic protein HVX61_12820 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase HVX61_12825 ENOG4105DSB aldose 1-epimerase HVX61_12830 ENOG4105CV8 reductase HVX61_12835 ENOG4105GNX MltA-interacting MipA family protein HVX61_12840 ENOG4105CYN Serine protein kinase HVX61_12850 ENOG4106KTS Inner membrane protein yeaI HVX61_12855 ENOG4108KHP Diguanylate cyclase HVX61_12860 ENOG4108KXH Ybak prolyl-tRNA synthetase associated HVX61_12875 ENOG4105R1U AraC Family Transcriptional Regulator HVX61_12880 ENOG4105DJ2 Major Facilitator Superfamily HVX61_12885 ENOG4105K78 MarR family Transcriptional regulator HVX61_12890 ENOG4105UCG Domain of unknown function (DUF333) HVX61_12895 ENOG410620I Diguanylate cyclase HVX61_12900 ENOG4106G4W HVX61_12910 ENOG4105Y3U Transglycosylase-associated protein HVX61_12915 ENOG4105YP6 Domain of unknown function (DUF1869) HVX61_12920 ENOG4108YS1 cytoplasmic protein HVX61_12930 ENOG4105EJC lysr family transcriptional regulator HVX61_12935 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) HVX61_12940 ENOG4105C94 Transporter HVX61_12945 ENOG4105DVW rieske (2Fe-2S) HVX61_12950 ENOG4105E3J oxidoreductase HVX61_12955 ENOG4105ZIE Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity) HVX61_12960 ENOG4105CEY Amp-dependent synthetase and ligase HVX61_12965 ENOG4105Y4Z Outer Membrane Lipoprotein HVX61_12970 ENOG41072GX Peptidase M22 Glycoprotease HVX61_12975 ENOG4105DVT helicase HVX61_12980 ENOG4105M4H endoribonuclease L-psp HVX61_12985 ENOG4105V2F Uncharacterized protein yoac HVX61_12995 ENOG4105CRQ synthase (Component I) HVX61_13005 ENOG4105EJQ L-serine dehydratase HVX61_13010 ENOG4107XTP (EAL) domain protein HVX61_13015 ENOG4105EE5 Membrane protein terC HVX61_13020 ENOG4105DAS pts system HVX61_13025 ENOG4105ETZ PTS System HVX61_13030 ENOG4105F3R pts system mannose fructose sorbose family iid HVX61_13045 ENOG4105DHI Methyltransferase HVX61_13060 ENOG4105Q3Y exported protein HVX61_13070 ENOG4105TIK HVX61_13080 ENOG4105J4Q Transcriptional regulator HVX61_13085 ENOG4105C0R drug resistance transporter emrb qaca subfamily HVX61_13100 ENOG4105CN1 protease HVX61_13110 ENOG4108ZGC gaf domain protein HVX61_13115 ENOG4105H2K paraquat-inducible protein a HVX61_13120 ENOG4105DY2 Paraquat-inducible protein b HVX61_13130 ENOG4105WT8 Protein of unknown function (DUF1480) HVX61_13135 ENOG4105UVW uncharacterized protein yebW HVX61_13140 ENOG4108R1E Serine threonine protein phosphatase 1 HVX61_13145 ENOG4105NKT exported protein HVX61_13150 ENOG4108PNC copper resistance HVX61_13155 ENOG4105FXM Copper resistance protein HVX61_13160 ENOG4105MPK DNA polymerase III subunit theta HVX61_13165 ENOG4108YGA nitrilase cyanide hydratase and apolipoprotein n-acyltransferase HVX61_13170 ENOG4105UMD exodeoxyribonuclease X HVX61_13175 ENOG4105CUG Oligopeptidase b HVX61_13180 ENOG4108Q2J Inner membrane protein YebE HVX61_13190 ENOG4105X2V dna damage-inducible protein HVX61_13200 ENOG4108UHU Aldolase HVX61_13205 ENOG4105C01 Dihydroxy-acid dehydratase HVX61_13210 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase HVX61_13215 ENOG4106KNT transcriptional regulator HVX61_13220 ENOG4105CA9 Pyruvate kinase HVX61_13225 ENOG4105NWR lipid A biosynthesis (Kdo)2-(Lauroyl)-lipid IVA acyltransferase HVX61_13230 ENOG4105DR5 peptidase HVX61_13235 ENOG4105NXV High-affinity zinc uptake system protein HVX61_13245 ENOG4105FAV ABC, transporter HVX61_13265 ENOG4107S01 Repressor protein MetJ HVX61_13275 ENOG4105CDY transcriptional regulatory protein HVX61_13280 ENOG4108TIT dATP pyrophosphohydrolase HVX61_13290 ENOG4105D3W isochorismatase HVX61_13295 ENOG41081XQ Conserved Protein HVX61_13300 ENOG4105WJG Glutathione HVX61_13315 ENOG4107QY8 reductase HVX61_13320 ENOG4105CUW cytochrome C-TYPE protein HVX61_13330 ENOG4106ZCM YecM protein HVX61_13345 ENOG4105W13 flagellar protein HVX61_13350 ENOG4105D7B Flagellar biosynthesis protein flha HVX61_13355 ENOG4105D00 flagellar biosynthetic protein flhB HVX61_13365 ENOG4108VYJ response regulator receiver protein HVX61_13375 ENOG4105BZU Histidine kinase HVX61_13380 ENOG4105C8Q Methyl-accepting chemotaxis HVX61_13385 ENOG4105C8Q Methyl-accepting chemotaxis HVX61_13390 ENOG4108V3W Chemotaxis protein, CheW HVX61_13395 ENOG4105CBS Chea signal transduction histidine kinase HVX61_13400 ENOG4105ER2 Ompa motb domain protein HVX61_13405 ENOG4107RD7 Flagellar Motor Protein, MotA HVX61_13410 ENOG4106CIA Functions in complex with FlhD as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region HVX61_13420 ENOG4108VA4 Universal stress protein HVX61_13430 ENOG4108K4C ec 3.1.3.12 HVX61_13435 ENOG4105CNN ABC, transporter HVX61_13440 ENOG4105C2J ABC transporter HVX61_13445 ENOG4105DMK Periplasmic binding protein LacI transcriptional regulator HVX61_13450 ENOG4108UEC Ferritin-like protein HVX61_13455 ENOG4105N4N Protein of unknown function (DUF2766) HVX61_13465 ENOG4105P23 (LipO)protein HVX61_13470 ENOG41090A1 ferritin HVX61_13475 ENOG4105VVZ metal-binding protein HVX61_13480 ENOG4105E0U tyrosine-specific transport protein HVX61_13485 ENOG4106RHG Yeca family HVX61_13515 ENOG4105WH1 Two component transcriptional regulator luxr family HVX61_13525 ENOG4105XVG cytoplasmic protein HVX61_13530 ENOG4105VJY transcriptional regulator HVX61_13535 ENOG4105CDA abc transporter atp-binding protein HVX61_13540 ENOG4105E5Q amino acid AbC transporter HVX61_13545 ENOG4105K6H D-cysteine desulfhydrase HVX61_13550 ENOG4105EAB amino acid AbC transporter HVX61_13555 ENOG4108M9K flagella biosynthesis protein FliZ HVX61_13560 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HVX61_13565 ENOG4105I03 Flagellin HVX61_13570 ENOG4105DTS flagellar hook-associated HVX61_13575 ENOG4105MQ3 flagellar protein FliS HVX61_13580 ENOG4105YXP it directly binds FlhC, thus inhibiting the binding of the FlhC FlhD complex to class 2 promoters, resulting in decreased expression of class 2 flagellar operons. As a chaperone, effects FliD transition to the membrane by preventing its premature polymerization, and by directing it to the export apparatus (By similarity) HVX61_13585 ENOG4105E5K Alpha-amylase HVX61_13590 ENOG4108W9D (LipO)protein HVX61_13595 ENOG41066VF YeeE YedE family protein HVX61_13605 ENOG4108RAV Conserved protein HVX61_13610 ENOG4108HF7 Gcn5-related n-acetyltransferase HVX61_13620 ENOG4105VQ0 flagellar hook-basal body complex protein fliE HVX61_13625 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) HVX61_13630 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) HVX61_13635 ENOG41090PJ Flagellar assembly protein HVX61_13640 ENOG4108JIR Flagellum-specific ATP synthase HVX61_13645 ENOG4105GSA Flagellar export protein flij HVX61_13650 ENOG4105WF4 Flagellar hook-length control protein HVX61_13655 ENOG4107ZI8 flagellar basal body-associated protein flil HVX61_13660 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) HVX61_13665 ENOG4105DD5 Flagellar motor switch protein HVX61_13670 ENOG4105K0P flagellar biosynthesis protein HVX61_13675 ENOG4105CN7 Flagellar biosynthetic protein FliP HVX61_13685 ENOG4105D19 Role in flagellar biosynthesis (By similarity) HVX61_13690 ENOG4107TKS colanic acid capsular biosynthesis activation protein A HVX61_13700 ENOG4105YX3 cellular response to acidity HVX61_13710 ENOG4105BZU Histidine kinase HVX61_13715 ENOG4105VNZ cytoplasmic protein HVX61_13720 ENOG4105CKW Inner membrane protein yedI HVX61_13725 ENOG4105FDR Membrane HVX61_13730 ENOG41090BB DNA mismatch endonuclease (vsr) HVX61_13735 ENOG4105DVF Cytosine-specific methyltransferase HVX61_13740 ENOG4105EST Metal Dependent Phosphohydrolase HVX61_13745 ENOG4105Y0K Inner membrane protein YedR HVX61_13750 ENOG4105ZIT Porin Gram-negative type HVX61_13760 ENOG4107ZY3 Histidine kinase HVX61_13765 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HVX61_13770 ENOG4105VT2 5-hydroxyisourate hydrolase HVX61_13780 ENOG4105DQ2 Is probably involved in the electron transfer between its heme and the molybdenum cofactor of the reductase catalytic subunit YedY (By similarity) HVX61_13785 ENOG4108MEK Metal-binding protein YodA HVX61_13790 ENOG4108VKM cytochrome b561 HVX61_13800 ENOG4105EXZ Involved in the regulation of ptsG expression by binding and inactivating Mlc (By similarity) HVX61_13810 ENOG4105TNG K13735 adhesin invasin HVX61_13820 ENOG4105CSH Transporter HVX61_13825 ENOG4105FYV Amp nucleosidase HVX61_13830 ENOG4105CDY transcriptional regulatory protein HVX61_13840 ENOG4105UQX Mate efflux family protein HVX61_13850 ENOG4107R11 Transcriptional regulator HVX61_13855 ENOG4106P55 Transcriptional regulator HVX61_13865 ENOG4108PXI ErfK YbiS YcfS YnhG HVX61_13870 ENOG4105CUP Catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide (NAMN) and 5,6- dimethylbenzimidazole (DMB) (By similarity) HVX61_13880 ENOG4108YZT Adenosylcobinamide kinase HVX61_13900 ENOG4105DR8 Membrane HVX61_13915 ENOG4105CJB Exodeoxyribonuclease I HVX61_13925 ENOG4105CUC YeeE YedE family protein HVX61_13930 ENOG4105CUB amino acid HVX61_13940 ENOG4105EQ1 Transcriptional regulator HVX61_13945 ENOG4107SRH Nad-dependent epimerase dehydratase HVX61_13950 ENOG4105KRQ Addiction module toxin, Txe YoeB family HVX61_13955 ENOG4105VTW prevent-host-death family HVX61_13980 ENOG4105ECC imidazole-glycerol-phosphate dehydratase HVX61_13985 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) HVX61_14000 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase HVX61_14005 ENOG4108KPN Confers a modal distribution of chain length on the O- antigen component of lipopolysaccharide (LPS). Gives rise to a reduced number of short chain molecules and increases in numbers of longer molecules, with a modal value of 13 (in strain O111 M92) and of 17 (in strain K12) HVX61_14015 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) HVX61_14025 ENOG4105CMR udp-glucose 4-epimerase HVX61_14055 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase HVX61_14060 ENOG4105DMT epimerase dehydratase HVX61_14065 ENOG4105G1A colanic acid biosynthesis protein HVX61_14070 ENOG4107T8Q Glycosyl transferase (Group 1 HVX61_14075 ENOG4105C74 pyruvyl transferase HVX61_14080 ENOG4105PSV Polysaccharide Biosynthesis Protein HVX61_14085 ENOG4105D3Q Sugar transferase HVX61_14090 ENOG4107QKV phosphomannomutase HVX61_14095 ENOG4105CJT Mannose-1-phosphate guanylyltransferase HVX61_14100 ENOG4106CD9 glycosyl transferase group 1 HVX61_14105 ENOG4105FGF GDP-mannose mannosyl hydrolase HVX61_14110 ENOG4105C30 Nad-dependent epimerase dehydratase HVX61_14115 ENOG4105C0K Gdp-mannose 4,6-dehydratase HVX61_14120 ENOG4108Z90 colanic acid biosynthesis acetyltransferase wcaF HVX61_14125 ENOG4105ECJ Glycosyl Transferase HVX61_14130 ENOG4108NYJ Colanic acid HVX61_14135 ENOG4107RXY Glycosyl transferase HVX61_14140 ENOG41068PY Colanic acid biosynthesis acetyltransferase wcaB HVX61_14145 ENOG41090RK glycosyl transferase HVX61_14150 ENOG4105D75 Capsular exopolysaccharide family HVX61_14155 ENOG4105KJF protein tyrosine phosphatase HVX61_14160 ENOG4105DAY polysaccharide export protein HVX61_14170 ENOG4105EE5 Membrane protein terC HVX61_14175 ENOG4105EQR Transposase IS116 IS110 IS902 HVX61_14180 ENOG4108GAE asmA family HVX61_14190 ENOG4105DBI uridine monophosphokinase HVX61_14195 ENOG4105BZU Histidine kinase HVX61_14200 ENOG4105D03 DNA-3-methyladenine glycosylase II HVX61_14205 ENOG4105R8A Heat shock protein HVX61_14210 ENOG4106E1W protein with protein kinase and helix-hairpin-helix DNA-binding HVX61_14215 ENOG4105UM3 Inherit from NOG: serine threonine phosphoprotein phosphatase HVX61_14220 ENOG4108M24 von Willebrand factor, type A HVX61_14235 ENOG4105IHM Involved in O antigen modification. Involved in the translocation of bactoprenol-linked glucose across the cytoplasmic membrane (By similarity) HVX61_14240 ENOG4105CKK Glycosyl transferase, family 2 HVX61_14285 ENOG4105EB3 Histidine kinase HVX61_14290 ENOG4105E3W Two component transcriptional regulator (Winged helix family HVX61_14295 ENOG4105KWI UPF0339 protein HVX61_14300 ENOG4105X54 addiction module antidote protein HVX61_14310 ENOG4105CFP Peptidase U32 HVX61_14315 ENOG4105ZTC transcriptional activator, Ogr delta HVX61_14375 ENOG4108X9F tail fiber protein HVX61_14375 ENOG4108X9F tail fiber protein HVX61_14470 ENOG4105ED4 portal protein HVX61_14495 ENOG4105VZ1 Replication Protein HVX61_14540 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HVX61_14545 ENOG41076Z6 Uncharacterized protein yegR HVX61_14560 ENOG4107WTH Galactitol-1-phosphate dehydrogenase HVX61_14565 ENOG4105DT3 PTS system, galactitol-specific IIc component HVX61_14570 ENOG41090UW PTS System HVX61_14575 ENOG41082GB PTS system galactitol-specific transporter subunit IIA HVX61_14590 ENOG4105EIE fructose-bisphosphate aldolase HVX61_14595 ENOG4105EAA nucleoside HVX61_14600 ENOG4108KD5 ADP-ribosylation crystallin J1 HVX61_14605 ENOG4108TFM Kinase, PfkB family HVX61_14610 ENOG4105FDP GntR family transcriptional regulator HVX61_14615 ENOG4108UQ1 hydrolase, family 25 HVX61_14620 ENOG4105DWF phosphomethylpyrimidine kinase HVX61_14635 ENOG41061MD high-affinity nickel-transporter HVX61_14640 ENOG4108Z1S Influences nickel and cobalt homeostasis. May act by modulating RcnA-mediated export of these ions to avoid excess efflux. Not involved in nickel import and does not bind nickel or cobalt ions directly HVX61_14645 ENOG410662B Type-1 fimbrial protein HVX61_14650 ENOG4105CW0 outer membrane usher protein HVX61_14655 ENOG4108MQF Chaperone HVX61_14660 ENOG41063W2 Fimbrial protein HVX61_14665 ENOG41067AK Protein of unknown function (DUF2574) HVX61_14670 ENOG4105D1F ATP-binding protein HVX61_14680 ENOG4108KDT Molybdate metabolism regulator HVX61_14685 ENOG4108KDT Molybdate metabolism regulator HVX61_14690 ENOG4108KDT Molybdate metabolism regulator HVX61_14700 ENOG4105KKX ATPase associated with various cellular activities aaa_5 HVX61_14705 ENOG4105RD5 HVX61_14710 ENOG4105DEG Vwa containing coxe family protein HVX61_14715 ENOG410903U zinc ion binding HVX61_14720 ENOG4108YCW (LipO)protein HVX61_14725 ENOG4108W15 Protein of unknown function (DUF1456) HVX61_14730 ENOG4108NEV two component transcriptional regulator, LytTR family HVX61_14735 ENOG4108HRK Histidine kinase HVX61_14740 ENOG4108XDN Transcriptional regulator HVX61_14750 ENOG4105WJV Binding-protein-dependent transport systems, inner membrane component HVX61_14755 ENOG4108IJ8 ABC transporter HVX61_14760 ENOG4107T5X Binding-protein-dependent transport systems, inner membrane component HVX61_14765 ENOG4107SI7 Substrate-binding region of abc-type glycine betaine transport system HVX61_14770 ENOG4107QK4 glycoside hydrolase, family 3 domain protein HVX61_14775 ENOG4105CXG d-lactate dehydrogenase HVX61_14780 ENOG41061WM D-Alanyl-D-Alanine HVX61_14785 ENOG41069YE inner membrane protein yohC HVX61_14790 ENOG4105KHU inner membrane protein YohD HVX61_14795 ENOG4105H9W Short-chain dehydrogenase reductase Sdr HVX61_14800 ENOG4105ETP RND efflux system, outer membrane lipoprotein HVX61_14810 ENOG4105EQR Transposase IS116 IS110 IS902 HVX61_14815 ENOG4105FBT Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity) HVX61_14820 ENOG4105MSY salicylate hydroxylase HVX61_14825 ENOG4108RXX maleylacetoacetate isomerase HVX61_14855 ENOG41067MG lrgb family HVX61_14865 ENOG4107GZ4 SanA protein HVX61_14870 ENOG4105Y9N Membrane HVX61_14875 ENOG4105BZ8 glutamate synthase HVX61_14880 ENOG4107SJI Dehydrogenase HVX61_14885 ENOG4108HWV )-transporter HVX61_14890 ENOG4105C2J ABC transporter HVX61_14895 ENOG4105EMA Periplasmic binding protein LacI transcriptional regulator HVX61_14900 ENOG41060NJ transcriptional regulator HVX61_14905 ENOG4105DHF Membrane HVX61_14915 ENOG4105C4W S-formylglutathione hydrolase HVX61_14920 ENOG4105D05 Receptor HVX61_14925 ENOG4108IQI permease HVX61_14930 ENOG4105DUM transcriptional regulator, lysR family HVX61_14935 ENOG4105HMI Membrane HVX61_14945 ENOG4105DD7 kinase (PfkB family HVX61_14950 ENOG4105D9N nucleoside HVX61_14960 ENOG4108Y4K DNA-binding transcriptional activator HVX61_14965 ENOG4105D9N nucleoside HVX61_14970 ENOG4105D53 Catalyzes the hydrolysis of pseudouridine 5'-phosphate (PsiMP) to ribose 5-phosphate and uracil (By similarity) HVX61_14975 ENOG4105DD7 kinase (PfkB family HVX61_14980 ENOG4105DM4 PTS System HVX61_14985 ENOG4105DE4 1-phosphofructokinase HVX61_14990 ENOG4105DTZ bifunctional PTS system fructose-specific transporter subunit IIA HPr protein HVX61_14995 ENOG4105S8Q sugar efflux transporter HVX61_15000 ENOG4105KRS Proteinase inhibitor HVX61_15010 ENOG4105DEI Mannitol dehydrogenase HVX61_15015 ENOG4105CKI cobalamin synthesis protein HVX61_15020 ENOG41076MN Phosphoesterase, PA-phosphatase related HVX61_15025 ENOG4107TT5 NLP P60 protein HVX61_15030 ENOG4105CXC rtn protein HVX61_15035 ENOG4105E43 Extracellular solute-binding protein, family 5 HVX61_15040 ENOG4108I5X binding-protein-dependent transport systems inner membrane Component HVX61_15045 ENOG4108IYQ Binding-protein-dependent transport systems inner membrane component HVX61_15050 ENOG4108JQ5 ABC transporter HVX61_15055 ENOG4105HG6 HVX61_15060 ENOG4105C2C drug resistance transporter, Bcr CflA HVX61_15065 ENOG4105I08 Pseudouridine synthase HVX61_15070 ENOG4105CFI type iii restriction protein res subunit HVX61_15090 ENOG4105E68 Sulfatase HVX61_15100 ENOG4108MGN ATP-binding component of a transport system HVX61_15105 ENOG4105WH1 Two component transcriptional regulator luxr family HVX61_15110 ENOG4105KWW Biogenesis protein HVX61_15115 ENOG4107QX9 Thiol disulfide interChange protein HVX61_15120 ENOG4105DA4 cytochrome c-type biogenesis protein HVX61_15130 ENOG4105X3C heme exporter protein HVX61_15135 ENOG41060IM Heme exporter protein HVX61_15140 ENOG4105CA5 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes (By similarity) HVX61_15145 ENOG4107EV4 once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system (By similarity) HVX61_15150 ENOG4105CUW cytochrome C-TYPE protein HVX61_15155 ENOG4108ZMS Electron transfer subunit of the periplasmic nitrate reductase complex NapAB (By similarity) HVX61_15160 ENOG4105GXZ Ferredoxin-type protein NapH HVX61_15165 ENOG4108BGM Quinol dehydrogenase periplasmic component HVX61_15175 ENOG41061Q0 Assembly protein for periplasmic nitrate reductase HVX61_15180 ENOG4108ZNS ferredoxin-type protein NapF HVX61_15195 ENOG4105IBP Cyclic peptide transporter HVX61_15200 ENOG4105CF1 Alkylated DNA repair protein HVX61_15205 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) HVX61_15210 ENOG4105CJ2 (LipO)protein HVX61_15215 ENOG4105FCK Membrane HVX61_15220 ENOG4105E3G Phosphotransfer intermediate protein in two-component regulatory system with RcsBC HVX61_15225 ENOG41068CG regulatoR HVX61_15230 ENOG4105BZU Histidine kinase HVX61_15235 ENOG4105BZU Histidine kinase HVX61_15240 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family HVX61_15245 ENOG4107QP7 CoA-transferase subunit A HVX61_15250 ENOG4107QNJ CoA-transferase subunit B HVX61_15255 ENOG4105CRW Short chain fatty acid transporter HVX61_15260 ENOG4105CHU acetyl-coa acetyltransferase HVX61_15265 ENOG4105EDV vault protein HVX61_15270 ENOG41081SK signal peptide protein HVX61_15275 ENOG4107S52 alpha-2-macroglobulin domain protein HVX61_15280 ENOG4108QJJ Protein of unknown function (DUF1175) HVX61_15285 ENOG4107FKF Uncharacterized protein conserved in bacteria (DUF2138) HVX61_15290 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HVX61_15300 ENOG4107GHC outer membrane autotransporter HVX61_15305 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HVX61_15310 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HVX61_15315 ENOG4105XPH Ferredoxin HVX61_15320 ENOG4105FQR PH-inducible protein involved in stress response HVX61_15325 ENOG4105CZM Major Facilitator HVX61_15330 ENOG4105GZI Transcriptional regulator HVX61_15335 ENOG4106MZZ glycerophosphoryl diester phosphodiesterase HVX61_15340 ENOG4105CXY transporter HVX61_15345 ENOG4107R5Y anaerobic glycerol-3-phosphate dehydrogenase, subunit A HVX61_15355 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) HVX61_15360 ENOG4105DNE Transposase HVX61_15370 ENOG4105CNV Aldolase HVX61_15375 ENOG4105CSP Major Facilitator Superfamily HVX61_15385 ENOG4107258 Transcriptional regulator HVX61_15390 ENOG4108EWA cinA-like protein HVX61_15395 ENOG4108UII YfaZ family HVX61_15445 ENOG4106GZG polymyxin resistance protein B HVX61_15450 ENOG4105CEY Amp-dependent synthetase and ligase HVX61_15460 ENOG4108IPT Naphthoate synthase HVX61_15475 ENOG4105E4F Isochorismate synthase HVX61_15480 ENOG4105TNS Conserved Protein HVX61_15485 ENOG4107YB6 acetyltransferase, (GNAT) family HVX61_15500 ENOG4105CP2 von willebrand factor, type a HVX61_15510 ENOG4105GDX Domain of unknown function (DUF1877) HVX61_15520 ENOG4105C8S subunit m HVX61_15525 ENOG4105D65 subunit l HVX61_15535 ENOG4107UFS subunit j HVX61_15550 ENOG4108IEH NADH dehydrogenase subunit g HVX61_15555 ENOG4107QIZ NADH dehydrogenase HVX61_15560 ENOG4105GKE subunit e HVX61_15580 ENOG4107NQ8 LysR family Transcriptional regulator HVX61_15585 ENOG4105CHM Aminotransferase HVX61_15595 ENOG4107QWE )-transporter HVX61_15600 ENOG4105EVE HAD-superfamily hydrolase subfamily IA variant 3 HVX61_15605 ENOG4105XWI UPF0304 protein HVX61_15615 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) HVX61_15620 ENOG4105C6K Malic enzyme HVX61_15625 ENOG4105CSX c4-dicarboxylate anaerobic carrier HVX61_15630 ENOG4105PTV Nudix Hydrolase HVX61_15635 ENOG4108RE9 Phosphodiesterase HVX61_15640 ENOG4108SHQ Glutathione S-transferase HVX61_15645 ENOG4105CYM Glutathione S-transferase HVX61_15650 ENOG4105KKP D-erythro-7,8-dihydroneopterin triphosphate 2'-epimerase HVX61_15655 ENOG4105ECP epimerase HVX61_15660 ENOG4105DNE Transposase HVX61_15665 ENOG4108JEH abc transporter atp-binding protein HVX61_15670 ENOG4106YG3 ABC transporter HVX61_15675 ENOG4105DSP amino acid AbC transporter HVX61_15680 ENOG4105E89 ABC transporter HVX61_15685 ENOG4105E89 ABC transporter HVX61_15690 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase HVX61_15695 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase HVX61_15700 ENOG4105E96 Colicin v production protein HVX61_15705 ENOG4108S3P Sporulation domain protein HVX61_15710 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase HVX61_15720 ENOG4105DQR SNARE associated Golgi HVX61_15730 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) HVX61_15740 ENOG4106WZ1 flagella biosynthesis regulator HVX61_15745 ENOG4105F9N Major Facilitator Superfamily HVX61_15750 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) HVX61_15760 ENOG4105MH2 YfcL protein HVX61_15765 ENOG4108BPE -transporting atpase HVX61_15770 ENOG4105EJ9 Membrane HVX61_15780 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase HVX61_15785 ENOG4105C76 Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity) HVX61_15800 ENOG4105US4 fimbrial-like protein yfcP HVX61_15805 ENOG4105UGQ Fimbrial HVX61_15810 ENOG4105NEV Fimbrial HVX61_15815 ENOG4108FZ9 Chaperone HVX61_15820 ENOG4106PG1 outer membrane usher protein HVX61_15830 ENOG4108BY2 phosphohistidine phosphatase HVX61_15845 ENOG4105KZW UPF0381 protein HVX61_15850 ENOG4105CKF membrane protein involved in aromatic hydrocarbon degradation HVX61_15860 ENOG410903C (LipO)protein HVX61_15865 ENOG4105S64 Formate nitrite transporter HVX61_15880 ENOG4105U0F oligosaccharide H symporter, major facilitator superfamily (MFS) HVX61_15885 ENOG4105D7K pfkb domain protein HVX61_15890 ENOG4108HKT sucrose-6-phosphate hydrolase HVX61_15895 ENOG4106NDP Transcriptional regulator HVX61_15905 ENOG4105BZC d-serine deaminase HVX61_15910 ENOG4105C0R drug resistance transporter emrb qaca subfamily HVX61_15915 ENOG4105CW7 secretion protein, HlyD family HVX61_15920 ENOG4108WQH regulatoR HVX61_15925 ENOG4105BZU Histidine kinase HVX61_15930 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F HVX61_15935 ENOG4108N2Y auxin Efflux HVX61_15940 ENOG4105CFN oxalyl-CoA decarboxylase HVX61_15950 ENOG4108V08 YfdX protein HVX61_15960 ENOG4105W9M Membrane HVX61_15965 ENOG4105D1S lipid A biosynthesis HVX61_15975 ENOG4105CHM Aminotransferase HVX61_15980 ENOG4108HRK Histidine kinase HVX61_15985 ENOG4105DY9 regulatoR HVX61_15990 ENOG4108CIP transcriptional regulator HVX61_15995 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) HVX61_16000 ENOG4105CN9 Peptidase m42 family protein HVX61_16005 ENOG4105DC7 peptidase M24 HVX61_16010 ENOG410863U PTS System HVX61_16015 ENOG4105R6B The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane (By similarity) HVX61_16025 ENOG4105VCT ion-transport protein YfeO HVX61_16030 ENOG4109076 Conserved Protein HVX61_16040 ENOG4105D9N nucleoside HVX61_16045 ENOG4108KMM Diguanylate cyclase HVX61_16060 ENOG4105HZG regulatoR HVX61_16065 ENOG4105GXM Putative transcription regulator (DUF1323) HVX61_16100 ENOG4108M0I Transcriptional regulator HVX61_16105 ENOG4105DHU Bile acid HVX61_16110 ENOG4105VRT cytoplasmic protein HVX61_16130 ENOG4105C6T cysteine synthase HVX61_16140 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) HVX61_16145 ENOG4105C5Y PTS System HVX61_16155 ENOG4105M0Y HVX61_16160 ENOG4105C6T cysteine synthase HVX61_16165 ENOG4108IJ6 ABC transporter HVX61_16170 ENOG4105ECW sulfate abc transporter HVX61_16175 ENOG4108I5D sulfate abc transporter HVX61_16180 ENOG4108J2H Sulfate ABC transporter periplasmic sulfate-binding protein HVX61_16185 ENOG4105I7Z Short-chain dehydrogenase reductase Sdr HVX61_16200 ENOG4105C5Y PTS System HVX61_16205 ENOG4107S1E Beta-lactamase HVX61_16210 ENOG4105EZR dyp-type peroxidase family protein HVX61_16215 ENOG4105E7K (LipO)protein HVX61_16220 ENOG4105QZU Inner membrane protein YfeZ HVX61_16230 ENOG4108KNB n-acetylmuramoyl-l-alanine amidase HVX61_16240 ENOG4108K3Z AraC family transcriptional regulator HVX61_16245 ENOG4108X49 Ethanolamine utilization protein EutK HVX61_16250 ENOG4106D67 ethanolamine utilization protein HVX61_16260 ENOG4105CPD ethanolamine ammonia-lyase HVX61_16265 ENOG4105DYY Reactivating factor for ethanolamine ammonia lyase HVX61_16270 ENOG4105ENY Ethanolamine utilization protein eutH HVX61_16275 ENOG4105C0A alcohol dehydrogenase HVX61_16280 ENOG4107RWI ethanolamine utilization protein eutJ HVX61_16285 ENOG4108EKI Dehydrogenase HVX61_16290 ENOG4105WVM ethanolamine utilization protein EutN carboxysome structural protein Ccml HVX61_16295 ENOG4105KNY Microcompartments protein HVX61_16300 ENOG4107WUY phosphate acetyltransferase HVX61_16305 ENOG4108PFF ethanolamine utilization cobalamin adenosyltransferase HVX61_16310 ENOG4105NDK ethanolamine utilization protein HVX61_16315 ENOG4106S4J ethanolamine utilization protein EutP HVX61_16320 ENOG4108VJN May be involved in the formation of a specific microcompartment in the cell in which the metabolism of potentially toxic by-products takes place HVX61_16325 ENOG4105C6K Malic enzyme HVX61_16330 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) HVX61_16335 ENOG4105CV1 Transketolase (EC 2.2.1.1) HVX61_16345 ENOG4108PVD exported protein HVX61_16355 ENOG4105BZ8 glutamate synthase HVX61_16360 ENOG4105BZU Histidine kinase HVX61_16365 ENOG4105BZS acriflavin resistance protein HVX61_16375 ENOG4105KUZ arsenate reductase HVX61_16390 ENOG4106KED esterase YpfH HVX61_16400 ENOG4105CGZ zinc metallopeptidase HVX61_16405 ENOG4105M0J Toxic component of a toxin-antitoxin (TA) module. A HVX61_16420 ENOG4107EG0 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) HVX61_16430 ENOG4105RH4 Glycine cleavage system transcriptional repressor HVX61_16435 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen HVX61_16440 ENOG4108MFN small subunit of hydrogenase-3, iron-sulfur protein (part of formate hydrogenlyase (FHL) complex) HVX61_16445 ENOG4108JPZ Monovalent cation H antiporter subunit D HVX61_16450 ENOG4107TDF Formate hydrogenlyase subunit 4 HVX61_16455 ENOG4105D65 subunit l HVX61_16460 ENOG4107WQX hydrogenase 4 membrane subunit HVX61_16465 ENOG4108JPZ Monovalent cation H antiporter subunit D HVX61_16470 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HVX61_16480 ENOG4105C47 NADH ubiquinone oxidoreductase 20 kda subunit HVX61_16485 ENOG4105I6X formate hydrogenlyase maturation HVX61_16490 ENOG4108JUA Transcriptional regulator HVX61_16495 ENOG4105TMB Formate nitrite transporter HVX61_16500 ENOG4105C02 permease HVX61_16505 ENOG4105ERG peptidase m48, ste24p HVX61_16510 ENOG4105K89 arsenate reductase HVX61_16515 ENOG4108KZ1 Mediates the interaction of DNA replication inititator protein DnaA with DNA polymerase subunit beta sliding clamp (dnaN). Stimulates hydrolysis of ATP-DnaA to ADP-DnaA, rendering DnaA inactive for reinititation, a process called regulatory inhibition of DnaA or RIDA (By similarity) HVX61_16520 ENOG4105C2W permease HVX61_16535 ENOG4108V3E phosphoribosylglycinamide formyltransferase HVX61_16540 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) HVX61_16545 ENOG4105C9X ppx gppa phosphatase HVX61_16550 ENOG4105BZU Histidine kinase HVX61_16560 ENOG41062G3 Protein of unknown function (DUF2633) HVX61_16565 ENOG4108ZMA Outer membrane lipoprotein HVX61_16570 ENOG41066DY Membrane HVX61_16575 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) HVX61_16580 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) HVX61_16605 ENOG4105VPD cellular component movement HVX61_16620 ENOG4105N21 Membrane HVX61_16650 ENOG4108JQB penicillin-binding protein 1C HVX61_16655 ENOG4105DN3 alpha-2-macroglobulin domain protein HVX61_16660 ENOG4105KHC sulfurtransferase HVX61_16665 ENOG4105YYA enhanced serine sensitivity protein SseB HVX61_16675 ENOG4105WVQ Fe-S assembly protein IscX HVX61_16680 ENOG4108ZIT Ferredoxin, 2FE-2S HVX61_16700 ENOG4107XTC May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins HVX61_16720 ENOG4105ECY inositol monophosphatase HVX61_16725 ENOG4107XM9 (LipO)protein HVX61_16730 ENOG4108MN2 Stationary phase inducible protein CsiE HVX61_16735 ENOG4105D8G Major Facilitator superfamily HVX61_16740 ENOG4108W5M transcriptional regulator HVX61_16745 ENOG4105FUY alpha subunit HVX61_16770 ENOG4108SB3 DoxX Family HVX61_16775 ENOG4108ZKT aldose 1-epimerase HVX61_16780 ENOG4105CPQ Dehydrogenase HVX61_16785 ENOG4105CNN ABC, transporter HVX61_16790 ENOG4108F37 ATP-binding component of a transport system HVX61_16795 ENOG4105FCA ABC transporter periplasmic-binding protein YphF HVX61_16800 ENOG4107HQ7 repeat protein HVX61_16805 ENOG4108NZE NAGC-like transcriptional regulator HVX61_16815 ENOG4108EGH Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) HVX61_16825 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family HVX61_16830 ENOG4108SKK alpha helix protein HVX61_16835 ENOG4107WP9 Histidine kinase HVX61_16840 ENOG4108ETH Formylglycinamide ribotide synthetase HVX61_16850 ENOG4108Z6B deaminase HVX61_16855 ENOG4105HYY HAD superfamily (Subfamily IF) hydrolase, YfhB HVX61_16860 ENOG4106G6Q Transcriptional regulator HVX61_16865 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding HVX61_16880 ENOG4105CSZ Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity) HVX61_16900 ENOG4105C3F Signal peptidase i HVX61_16910 ENOG4105WMJ Positive regulator of sigma E, RseC MucC HVX61_16915 ENOG4105VQK sigma E regulatory protein, MucB RseB HVX61_16920 ENOG41069PW sigma-e factor negative regulatory protein HVX61_16925 ENOG4105EMN RNA polymerase sigma factor HVX61_16935 ENOG4108IYU L-aspartate oxidase HVX61_16945 ENOG4105C1J atp-dependent rna helicase HVX61_16950 ENOG41090KR LysR family transcriptional Regulator HVX61_16955 ENOG4108VP3 Lysine exporter protein (LysE YggA) HVX61_16975 ENOG4105EIB trna rrna methyltransferase HVX61_16980 ENOG4105K63 Thioredoxin HVX61_16985 ENOG4106IUH DTW domain containing protein HVX61_16990 ENOG4105CD5 CoA-binding domain protein HVX61_16995 ENOG4105JIM Phosphatidylserine synthase HVX61_17000 ENOG4105T42 (LipO)protein HVX61_17005 ENOG4105CSH Transporter HVX61_17030 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit HVX61_17035 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase HVX61_17040 ENOG4105C34 Pseudouridine synthase HVX61_17045 ENOG4106SNF Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane HVX61_17050 ENOG4108WPH sigma 54 modulation protein ribosomal protein S30EA HVX61_17060 ENOG4105CQC Prephenate dehydratase HVX61_17065 ENOG4105EHE chorismate mutase- prephenate dehydrogenase HVX61_17070 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) HVX61_17075 ENOG4105QP9 Protein of unknown function (DUF2799) HVX61_17080 ENOG4108WS1 HVX61_17085 ENOG4108KHX Diguanylate cyclase HVX61_17090 ENOG41090EK ompa motb domain protein HVX61_17115 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY HVX61_17120 ENOG4106KVJ cytochrome C assembly protein HVX61_17140 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) HVX61_17145 ENOG4105YRI Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) HVX61_17155 ENOG4108Z1B Cyclase dehydrase HVX61_17170 ENOG4105DFP Integrase HVX61_17240 ENOG4108MGN ATP-binding component of a transport system HVX61_17275 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) HVX61_17300 ENOG4108P8R HVX61_17315 ENOG4105JXR Protein of unknown function (DUF3296) HVX61_17325 ENOG4108MXD gtp-binding protein HVX61_17330 ENOG4108KZE transcriptional regulator HVX61_17355 ENOG4106H6R UPF0380 protein HVX61_17360 ENOG4105MFG Antirestriction protein HVX61_17365 ENOG4108XS9 dna repair protein HVX61_17370 ENOG4105ZS6 Protein of unknown function (DUF987) HVX61_17375 ENOG4105MAW Antitoxin component of a toxin-antitoxin (TA) module. Labile antitoxin that counteracts the effect of the CbtA (YeeV) toxin. It does not bind to the cognate toxin but instead binds to MreB and FtsZ (the toxin targets), enhancing their polymerization by forming higher-order bundles HVX61_17380 ENOG4108X3P Toxic component of a toxin-antitoxin (TA) module. Overexpression results in inhibition of growth in liquid cultures HVX61_17390 ENOG4105E54 alpha-amylase HVX61_17400 ENOG4105D5U fad dependent oxidoreductase HVX61_17405 ENOG4105C26 Dehydrogenase HVX61_17410 ENOG4108JPW Aminotransferase HVX61_17415 ENOG4105C85 amino acid HVX61_17420 ENOG4108PVQ transcriptional regulator HVX61_17425 ENOG4109066 lysm domain bon superfamily protein HVX61_17430 ENOG4105VPI YqaE family transport protein HVX61_17435 ENOG41080HT Transcriptional regulator, arsr family HVX61_17440 ENOG4108V62 Rhodanese domain protein HVX61_17445 ENOG4108X73 DNA- binding protein HVX61_17450 ENOG4108RNS Exports L-alanine (By similarity) HVX61_17455 ENOG4108WMJ Protein of unknown function (DUF2002) HVX61_17460 ENOG4108ZQZ Bacterial protein of unknown function (DUF883) HVX61_17465 ENOG4105WAZ (Glutaredoxin-like protein) NrdH HVX61_17475 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HVX61_17480 ENOG4107R25 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HVX61_17485 ENOG4108IJ7 Glycine betaine HVX61_17490 ENOG4108HQS Glycine betaine HVX61_17495 ENOG4105GIJ Glycine betaine HVX61_17500 ENOG4105EQ0 Major Facilitator superfamily HVX61_17505 ENOG4108UMN azlc family HVX61_17510 ENOG4105ZED uncharacterized protein ygaH HVX61_17515 ENOG4105NTK Transcriptional repressor Mpra HVX61_17520 ENOG4105CW7 secretion protein, HlyD family HVX61_17525 ENOG4105C0R drug resistance transporter emrb qaca subfamily HVX61_17540 ENOG4105W39 Membrane HVX61_17545 ENOG4107VXZ Hydrolase HVX61_17575 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) HVX61_17595 ENOG4107TH8 cina domain protein HVX61_17600 ENOG4105CVE Lytic murein transglycosylase HVX61_17605 ENOG410787A Pts system, glucitol sorbitol-specific HVX61_17610 ENOG4105DZY Pts system, glucitol sorbitol-specific HVX61_17615 ENOG4105VI0 Pts system, glucitol sorbitol-specific HVX61_17620 ENOG4107QMF Sorbitol-6-phosphate dehydrogenase HVX61_17625 ENOG4105J92 DNA-binding transcriptional activator GutM HVX61_17630 ENOG410804X Transcriptional regulator HVX61_17655 ENOG4105C8H hydrogenase maturation protein Hypf HVX61_17660 ENOG4108RC0 Electron transport protein HVX61_17665 ENOG4105DDV Transcriptional regulator (LacI family HVX61_17670 ENOG4105C5Y PTS System HVX61_17675 ENOG4105CS2 ec 3.2.1.21 HVX61_17680 ENOG4108MG9 hydrogenase 3 maturation protease HVX61_17685 ENOG4105I6X formate hydrogenlyase maturation HVX61_17690 ENOG4105C47 NADH ubiquinone oxidoreductase 20 kda subunit HVX61_17695 ENOG4108RG7 formate hydrogenlyase complex iron-sulfur subunit HVX61_17700 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HVX61_17705 ENOG4107TDF Formate hydrogenlyase subunit 4 HVX61_17710 ENOG4107R30 NADH dehydrogenase HVX61_17715 ENOG4108MFN small subunit of hydrogenase-3, iron-sulfur protein (part of formate hydrogenlyase (FHL) complex) HVX61_17720 ENOG4108VRC Formate hydrogenlyase regulatory protein hycA HVX61_17725 ENOG410816D Probably plays a role in a hydrogenase nickel cofactor insertion step (By similarity) HVX61_17730 ENOG4107RSS Hydrogenase accessory protein HypB HVX61_17735 ENOG41083WG hydrogenase assembly chaperone HVX61_17740 ENOG4105CQS hydrogenase expression formation protein HypD HVX61_17745 ENOG4105C45 hydrogenase expression formation protein (HypE) HVX61_17750 ENOG4108JUA Transcriptional regulator HVX61_17760 ENOG4105VXR cytoplasmic protein HVX61_17775 ENOG4105MEW serine threonine protein phosphatase HVX61_17780 ENOG4105MVE transcriptional regulator HVX61_17785 ENOG4105ZXK Dehydrogenase HVX61_17790 ENOG4105G63 Type III effector Hrp-dependent HVX61_17795 ENOG4105FB2 class II Aldolase HVX61_17800 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) HVX61_17805 ENOG4105C6Z Gluconate HVX61_17810 ENOG4105KZM cytoplasmic protein HVX61_17815 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) HVX61_17820 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase HVX61_17835 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HVX61_17840 ENOG4108K5P (LipO)protein HVX61_17875 ENOG4105N0Z inner membrane protein ygbE HVX61_17895 ENOG4108MXK alkaline phosphatase isozyme conversion HVX61_17900 ENOG4105PWE CRISPR-associated protein cas2 HVX61_17905 ENOG4105TZK CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. May be involved in the integration of spacer DNA into the CRISPR cassette (By similarity) HVX61_17910 ENOG4108Y7V CRISPR-associated protein, Cse3 family HVX61_17915 ENOG4108VWQ crispr-associated protein HVX61_17920 ENOG41060M0 Crispr-associated protein, cse4 family HVX61_17925 ENOG41061HK CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA) HVX61_17930 ENOG4105CYR Crispr-associated protein, cse1 family HVX61_17935 ENOG4105DTT CRISPR-associated helicase, cas3 HVX61_17955 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase HVX61_17960 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase HVX61_17965 ENOG4105WQV ferredoxin-like protein HVX61_17970 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator HVX61_17975 ENOG4105YBM electron transfer flavoprotein subunit ygcQ HVX61_17980 ENOG4106IKH Electron transfer flavoprotein HVX61_17985 ENOG4105C54 Major Facilitator superfamily HVX61_17995 ENOG4105CHR reductase HVX61_18000 ENOG4108ITV Inner membrane protein yqcE HVX61_18005 ENOG4108CWB sugar kinase ygcE HVX61_18010 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) HVX61_18020 ENOG4105HA9 of methanol dehydrogenase type HVX61_18030 ENOG4105HA9 of methanol dehydrogenase type HVX61_18045 ENOG4105DXN mazG family HVX61_18050 ENOG4105MZG transcriptional modulator of maze toxin, mazf HVX61_18055 ENOG4106A2Z transcriptional regulator antitoxin, MazE HVX61_18060 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) HVX61_18070 ENOG4105BZU Histidine kinase HVX61_18075 ENOG4105EQX glucarate dehydratase HVX61_18080 ENOG4105EQX glucarate dehydratase HVX61_18085 ENOG4105DJB Major Facilitator Superfamily HVX61_18090 ENOG4105QDK Flavodoxin HVX61_18095 ENOG4105DR9 pseudouridine synthase HVX61_18100 ENOG4105WP7 tRNA pseudouridine synthase C HVX61_18115 ENOG4105EWT decarboxylase family HVX61_18120 ENOG4105C44 Serine transporter HVX61_18125 ENOG4105EJQ L-serine dehydratase HVX61_18135 ENOG4105C0A alcohol dehydrogenase HVX61_18140 ENOG4107W7X Aldolase HVX61_18145 ENOG4105EDR glucose galactose transporter HVX61_18155 ENOG4105CMG Carbohydrate kinase HVX61_18165 ENOG4107EDW L-fucose operon activator HVX61_18175 ENOG4105M08 Membrane HVX61_18180 ENOG4105ETT transcriptional Regulator, LysR family HVX61_18185 ENOG4105M5B (LipO)protein HVX61_18190 ENOG4105C9B Cysteine desulfurase HVX61_18195 ENOG4105P9C Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity) HVX61_18200 ENOG4105CUZ uba thif-type nad fad binding protein HVX61_18205 ENOG4105CA3 membrane-bound lytic murein transglycosylase HVX61_18225 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase HVX61_18230 ENOG4108EKC n-acetylglutamate synthase HVX61_18235 ENOG4107QYX exodeoxyribonuclease v alpha HVX61_18240 ENOG4107QKA exodeoxyribonuclease V beta HVX61_18245 ENOG4107QXK peptidase HVX61_18250 ENOG4105DSY exodeoxyribonuclease V, gamma HVX61_18255 ENOG4105RVB Prepilin peptidase dependent protein c HVX61_18260 ENOG4105SEN Protein of unknown function (DUF2509) HVX61_18265 ENOG4105JCS prepilin peptidase dependent protein HVX61_18270 ENOG4105IPU prepilin peptidase dependent protein A HVX61_18285 ENOG4108HRM phosphoenolpyruvate--protein phosphotransferase HVX61_18300 ENOG4105EE5 Membrane protein terC HVX61_18305 ENOG4105SUV lipoprotein YgdR HVX61_18310 ENOG4105CPC Aldo Keto reductase HVX61_18325 ENOG41060NJ transcriptional regulator HVX61_18335 ENOG4105RQF LysR family Transcriptional regulator HVX61_18345 ENOG4107QNK )-transporter HVX61_18355 ENOG4105CHR reductase HVX61_18365 ENOG4105CHU acetyl-coa acetyltransferase HVX61_18370 ENOG4108MHD transport protein HVX61_18375 ENOG4105ISV protein with bipartite regulator domain HVX61_18380 ENOG4108TC1 Transcriptional regulator HVX61_18385 ENOG4105FV3 HVX61_18410 ENOG4108YAB Invasion protein HVX61_18420 ENOG4105K5T PilT protein HVX61_18445 ENOG4106BTR HVX61_18450 ENOG4105Y7Q type iii secretion HVX61_18455 ENOG4108RC9 Type III secretion system protein HVX61_18470 ENOG4108M6W surface presentation of antigens protein SpaS HVX61_18475 ENOG4108TN6 type iii secretion HVX61_18480 ENOG4105U07 type iii secretion HVX61_18485 ENOG41075IY surface presentation of antigens protein SpaP HVX61_18505 ENOG4108JIR Flagellum-specific ATP synthase HVX61_18510 ENOG4108HR8 type iii secretion HVX61_18515 ENOG4108N8R Invasion protein HVX61_18525 ENOG41090HZ type iii secretion HVX61_18535 ENOG4108T88 HVX61_18545 ENOG4108K5P (LipO)protein HVX61_18550 ENOG4105C7W Xanthine dehydrogenase HVX61_18555 ENOG4108HR6 Dehydrogenase HVX61_18560 ENOG4108UTP (2Fe-2S)-binding domain protein HVX61_18565 ENOG4108JUB Transcriptional regulator HVX61_18570 ENOG4105IW6 Carbamoyltransferase HVX61_18575 ENOG4107RCH Diaminopropionate ammonia-lyase HVX61_18580 ENOG4107S4Y M20 DapE family protein YgeY HVX61_18590 ENOG4105C5B carbamate kinase HVX61_18595 ENOG4107P0T Selenium-dependent molybdenum hydroxylase system protein, YqeB family HVX61_18600 ENOG4105MJ6 selenium-dependent hydroxylase accessory protein YqeC HVX61_18605 ENOG4105MFX 4-diphosphocytidyl-2c-methyl-d-erythritol synthase HVX61_18610 ENOG4105BZ8 glutamate synthase HVX61_18615 ENOG4107UUR Chlorohydrolase aminohydrolase HVX61_18620 ENOG410873Y FAD binding domain in molybdopterin dehydrogenase HVX61_18625 ENOG4105C7W Xanthine dehydrogenase HVX61_18630 ENOG4105C2W permease HVX61_18635 ENOG4107QUY Guanine deaminase HVX61_18640 ENOG4105C7N Xanthine uracil vitamin C permease HVX61_18645 ENOG4108R8B oxidoreductase Fe-S subunit HVX61_18650 ENOG4105BZ8 glutamate synthase HVX61_18655 ENOG4105C2W permease HVX61_18685 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) HVX61_18690 ENOG4105T95 Thiol disulfide interChange protein HVX61_18695 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HVX61_18700 ENOG41071R3 Low-potential electron donor to a number of redox enzymes (By similarity) HVX61_18705 ENOG4108YDB Toxic component of a toxin-antitoxin (TA) module. Overexpression leads to growth arrest after 5 hours, with initial elongation of cells, followed by swelling. The toxic effects are abrogated by coexpression with antitoxin CptB. Interacts with cytoskeletal proteins FtsZ and MreB HVX61_18710 ENOG4105Y75 tpr repeat protein HVX61_18720 ENOG4108UT2 hemolysin iii HVX61_18725 ENOG4105N5Z UPF0267 protein HVX61_18730 ENOG4105CS2 ec 3.2.1.21 HVX61_18735 ENOG4105CYX Short-chain dehydrogenase reductase Sdr HVX61_18760 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family HVX61_18765 ENOG4105D0A hydroxylase HVX61_18770 ENOG4107RAQ aminopeptidase HVX61_18790 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase HVX61_18800 ENOG4108JQ1 Dehydrogenase HVX61_18815 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) HVX61_18820 ENOG4105RC8 Reduces the permeability of the outer membrane to copper. Seems to be involved in the regulation of biofilm formation. May decrease biofilm formation by repressing cell-cell interaction and cell surface interaction HVX61_18825 ENOG4105E3J oxidoreductase HVX61_18835 ENOG4105D5P Methylmalonyl-coA mutase HVX61_18840 ENOG4105DJT lAO AO transport system ATPase HVX61_18845 ENOG4108M7F enoyl-CoA hydratase isomerase HVX61_18855 ENOG4105DEQ transcriptional regulator HVX61_18860 ENOG4105MPN Membrane HVX61_18865 ENOG4108ZUB Lysine exporter protein (Lyse ygga) HVX61_18870 ENOG4105D64 Mechanosensitive ion channel HVX61_18875 ENOG4105D2N Aldolase HVX61_18890 ENOG4107Z1W Fructose transport system kinase HVX61_18895 ENOG4108R4K DNA-binding, transcriptional regulator HVX61_18900 ENOG4108Q8A Fructose-1,6-bisphosphatase HVX61_18905 ENOG4105DXH Alcohol dehydrogenase zinc-binding domain protein HVX61_18910 ENOG4105CTS PTS system mannitol-specific HVX61_18915 ENOG4108X7Y Mannitol-specific cryptic phosphotransferase enzyme iia HVX61_18920 ENOG4105EPW hflc protein HVX61_18925 ENOG4105CV1 Transketolase (EC 2.2.1.1) HVX61_18930 ENOG4108K0D peptidase, M48 HVX61_18945 ENOG4105DP5 Catalyzes the biosynthesis of agmatine from arginine (By similarity) HVX61_18965 ENOG4107QNK )-transporter HVX61_18975 ENOG4105RWS endonuclease I HVX61_18980 ENOG4105QF0 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) HVX61_18985 ENOG4105D7Z glutathione synthase HVX61_19000 ENOG4105CZX twitching motility protein HVX61_19005 ENOG4105DFA alanine racemase domain protein HVX61_19010 ENOG4108VIA integral membrane protein HVX61_19020 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) HVX61_19025 ENOG4105CSA Coproporphyrinogen iii oxidase HVX61_19030 ENOG4106MH3 alpha helix chain HVX61_19035 ENOG4105HDK L-asparaginase HVX61_19040 ENOG4105K33 Periplasmic Protein HVX61_19045 ENOG41090ED Protein with unknown function (DUF469) HVX61_19055 ENOG4105CEN a g-specific adenine glycosylase HVX61_19070 ENOG4105EAA nucleoside HVX61_19075 ENOG4105CXN decarboxylase HVX61_19080 ENOG4108UQV Membrane HVX61_19210 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit HVX61_19350 ENOG4105DAA L-lactate HVX61_19355 ENOG4107QP3 malate synthase g HVX61_19360 ENOG4108ZJF Glcg protein HVX61_19365 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) HVX61_19370 ENOG4105EU8 FAD linked oxidase domain protein HVX61_19375 ENOG4105CQB FAD linked oxidase domain protein HVX61_19380 ENOG4108KWP DNA-binding transcriptional regulator GlcC HVX61_19390 ENOG4107RCI amp-dependent synthetase and ligase HVX61_19400 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) HVX61_19405 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) HVX61_19415 ENOG4108M8S permease YjgP YjgQ family protein HVX61_19420 ENOG4108UUE Transcriptional regulator HVX61_19430 ENOG4108S55 polysaccharide biosynthesis protein HVX61_19435 ENOG4106FPV ATP-binding protein YghR HVX61_19440 ENOG4108NDC ATP-binding protein yghS HVX61_19445 ENOG4108GH0 ATP-binding protein yghT HVX61_19450 ENOG4105CJ3 phosphate transporter HVX61_19455 ENOG4106032 Glutathionylspermidine synthase HVX61_19460 ENOG4105CYM Glutathione S-transferase HVX61_19465 ENOG41082MF Hydrogenase assembly chaperone hypC hupF HVX61_19475 ENOG4108WGS hydrogenase 2-specific chaperone HVX61_19480 ENOG4108USZ hydrogenase HVX61_19485 ENOG4105DPX Hydrogenase, large subunit HVX61_19490 ENOG4105CJ5 hydrogenase 2 b cytochrome subunit HVX61_19495 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein HVX61_19500 ENOG4105E3S small subunit HVX61_19505 ENOG410900S Protein of unknown function (DUF2623) HVX61_19515 ENOG4105CPC Aldo Keto reductase HVX61_19525 ENOG4105CYX Short-chain dehydrogenase reductase Sdr HVX61_19530 ENOG4108ZZF transport protein (ExbD) HVX61_19535 ENOG4105CWK Biopolymer transport protein, ExbB HVX61_19540 ENOG4105C28 cystathionine HVX61_19545 ENOG4108K81 inner membrane protein YghB HVX61_19550 ENOG4105CF7 AraC family transcriptional regulator HVX61_19555 ENOG4108I6A alcohol dehydrogenase HVX61_19560 ENOG4105CV8 reductase HVX61_19565 ENOG4105ZKC Conserved Protein HVX61_19575 ENOG4105CCT upf0313 protein HVX61_19580 ENOG4107TZ2 Cell division protein that is required for growth during stress conditions. May be involved in protecting or stabilizing the divisomal assembly under conditions of stress (By similarity) HVX61_19585 ENOG4107S7E 1-acyl-sn-glycerol-3-phosphate acyltransferase HVX61_19590 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HVX61_19595 ENOG4108J59 Extracellular solute-binding protein, family 5 HVX61_19600 ENOG4105F4I Transcriptional regulator HVX61_19605 ENOG4105H4F exported protein HVX61_19610 ENOG4105XJC Two component transcriptional regulator (Winged helix family HVX61_19615 ENOG4105DHQ Histidine kinase HVX61_19620 ENOG4105NF4 modulator of drug activity HVX61_19625 ENOG4105VRH Antibiotic biosynthesis monooxygenase HVX61_19630 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HVX61_19635 ENOG4105IPS esterase HVX61_19640 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) HVX61_19645 ENOG4108SX3 cytoplasmic protein HVX61_19650 ENOG41087AY ADP-Ribose pyrophosphatase HVX61_19655 ENOG4105DFG type I secretion outer membrane protein HVX61_19665 ENOG4106032 Glutathionylspermidine synthase HVX61_19670 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b HVX61_19690 ENOG4105W0Z cytoplasmic protein HVX61_19700 ENOG4105PV3 Inner membrane protein yqiJ HVX61_19705 ENOG4107S78 Band 7 protein HVX61_19725 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) HVX61_19730 ENOG4105I7R Adenylate cyclase HVX61_19735 ENOG4106MWK domain protein HVX61_19750 ENOG4107ZVW dihydroneopterin aldolase HVX61_19760 ENOG4105EJC lysr family transcriptional regulator HVX61_19765 ENOG4106DSS Tartrate dehydratase subunit alpha HVX61_19770 ENOG4107GFK fumarate HVX61_19775 ENOG4107QPK )-transporter HVX61_19780 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) HVX61_19790 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) HVX61_19795 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HVX61_19810 ENOG4105Q26 Siderophore-interacting protein HVX61_19815 ENOG4105NTW Transcriptional regulator HVX61_19820 ENOG4107RHT methyl-accepting chemotaxis sensory transducer with Pas Pac sensor HVX61_19830 ENOG4108Y51 tRNA-binding protein HVX61_19835 ENOG4105CQ4 Transcriptional regulator HVX61_19840 ENOG4105CNT hydrolase family 2 HVX61_19845 ENOG4105FK9 beta-D-galactosidase beta subunit HVX61_19850 ENOG4105E5D amino acid HVX61_19855 ENOG4107W6W Conserved Protein HVX61_19860 ENOG4107WCA isomerase HVX61_19865 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HVX61_19870 ENOG4108Z3N Transcriptional regulator HVX61_19885 ENOG4108VKG metal-dependent hydrolase HVX61_19890 ENOG4108UB4 uncharacterized protein ygjQ HVX61_19895 ENOG4105EE0 oxidoreductase HVX61_19900 ENOG4105DU1 integral membrane protein, terc HVX61_19905 ENOG4107QV7 Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system) (By similarity) HVX61_19910 ENOG4105P66 Membrane HVX61_19915 ENOG4105CTX dehydratase HVX61_19925 ENOG4105DPW Major facilitator superfamily MFS_1 HVX61_19930 ENOG4107YCY Transcriptional regulator HVX61_19935 ENOG4106W5V Membrane HVX61_19940 ENOG4105IYR Modulates the activity of the EnvZ OmpR two-component regulatory system, probably by directly modulating EnvZ enzymatic activity and increasing stability of phosphorylated OmpR (By similarity) HVX61_19945 ENOG4105WAY exported protein HVX61_19950 ENOG4105NE1 Conserved Protein HVX61_19955 ENOG41090KG Inner membrane protein YqjE HVX61_19960 ENOG4105YJD HVX61_19965 ENOG4108VBZ doxx family HVX61_19970 ENOG4105CHF Glutathione S-transferase HVX61_19975 ENOG4105KAF membrAne HVX61_19980 ENOG4105KAF membrAne HVX61_19985 ENOG4105CWB LysR family transcriptional Regulator HVX61_19990 ENOG4108CNN domain protein HVX61_19995 ENOG4106D80 Uncharacterized protein YhaL HVX61_20005 ENOG4105C44 Serine transporter HVX61_20010 ENOG4105EJQ L-serine dehydratase HVX61_20015 ENOG4105KME endoribonuclease L-psp HVX61_20020 ENOG4105C6N Formate acetyltransferase HVX61_20025 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) HVX61_20035 ENOG4105C7B Threonine dehydratase HVX61_20040 ENOG410811B TRANSCRIPTIONal HVX61_20065 ENOG4105BZW Glycerate kinase HVX61_20070 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase HVX61_20080 ENOG4105DJB Major Facilitator Superfamily HVX61_20085 ENOG4105CTX dehydratase HVX61_20090 ENOG4105ZEG Suppressor protein HVX61_20100 ENOG4105E98 transcriptional regulator DeoR family HVX61_20110 ENOG4108RG5 PTS system N-acetylgalactosamine-specific transporter subunit IIB HVX61_20120 ENOG4105F3R pts system mannose fructose sorbose family iid HVX61_20125 ENOG4108YTN IIa component HVX61_20130 ENOG4105CE4 GlcNAc 6-P deacetylase HVX61_20135 ENOG4105E70 isomerase HVX61_20145 ENOG4108UZY PTS System HVX61_20150 ENOG4105ETZ PTS System HVX61_20155 ENOG4105F3R pts system mannose fructose sorbose family iid HVX61_20160 ENOG4106HBN Galactosamine-6-phosphate isomerase HVX61_20175 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) HVX61_20180 ENOG4105E1C Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1A (PBP1a) (By similarity) HVX61_20195 ENOG4105W4M Transport-associated protein HVX61_20200 ENOG4107S21 permease HVX61_20205 ENOG4105K4T epimerase HVX61_20210 ENOG4107R7Y intracellular protease Pfpi family HVX61_20225 ENOG4108YYD acetyltransferase HVX61_20245 ENOG4105DEN Luciferase family HVX61_20250 ENOG4105CIC tryptophan-specific transport protein HVX61_20255 ENOG4105C1J atp-dependent rna helicase HVX61_20295 ENOG4105CHV Transcription elongation factor NusA HVX61_20315 ENOG4105DIJ Phosphoethanolamine transferase HVX61_20325 ENOG4105NTZ Preprotein translocase subunit SecG HVX61_20335 ENOG4105EEI dihydropteroate synthase HVX61_20340 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) HVX61_20350 ENOG4105HBR Rna-binding protein HVX61_20355 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) HVX61_20360 ENOG4106HRJ d-alanyl-d-alanine carboxypeptidase HVX61_20370 ENOG4105QYV Membrane HVX61_20385 ENOG4105EAH synthase HVX61_20390 ENOG4105HVQ Regulatory factor of maltose metabolism HVX61_20400 ENOG4105VFK BolA family HVX61_20405 ENOG4105UE2 Part of the ABC transporter complex MlaFEDB that actively prevents phospholipid accumulation at the cell surface. Probably maintains lipid asymmetry in the outer membrane by retrograde trafficking of phospholipids from the outer membrane to the inner membrane HVX61_20410 ENOG4105E3I toluene tolerance HVX61_20415 ENOG4107PE3 Mammalian cell entry related domain protein HVX61_20420 ENOG4105CY3 ABC transporter, permease HVX61_20425 ENOG4105DHJ ABC, transporter HVX61_20430 ENOG4105FEU K -dependent Na -Ca exchanger HVX61_20435 ENOG4105C2X Arabinose 5-phosphate isomerase HVX61_20440 ENOG4108Z4R 3-deoxy-d-manno-octulosonate 8-phosphate phosphatase HVX61_20445 ENOG4108P1K Required for the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane (By similarity) HVX61_20450 ENOG4105WI0 lipopolysaccharide transport periplasmic protein lptA HVX61_20455 ENOG4108IUZ ABC transporter HVX61_20460 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HVX61_20465 ENOG41080QH sigma 54 modulation protein ribosomal protein S30EA HVX61_20470 ENOG4107RM2 PTS IIA-like nitrogen-regulatory protein PtsN HVX61_20480 ENOG41080Z8 PHOSPHOCARRIER protein HVX61_20485 ENOG4108NIH transferase activity, transferring phosphorus-containing groups HVX61_20495 ENOG4108556 Isoprenoid biosynthesis protein with amidotransferase-like domain HVX61_20500 ENOG4105BZU Histidine kinase HVX61_20505 ENOG4105N5T Radical SAM Protein HVX61_20510 ENOG4105CBC glutamate synthase HVX61_20515 ENOG4105BZ8 glutamate synthase HVX61_20520 ENOG4105DFS Conserved Protein HVX61_20525 ENOG4108R66 Conserved Protein HVX61_20540 ENOG4105JHE Major Facilitator Superfamily HVX61_20550 ENOG4108QBF Transcriptional regulator HVX61_20555 ENOG4105CEE C4-dicarboxylate transporter HVX61_20560 ENOG4105KB2 stringent starvation protein b HVX61_20565 ENOG4107MKT Stringent starvation protein a HVX61_20580 ENOG4105D6Z AFG1 family ATPase HVX61_20585 ENOG4108W2Q Cytochrome d ubiquinol oxidase subunit III HVX61_20590 ENOG4105C0H protease HVX61_20595 ENOG4105C0H protease HVX61_20615 ENOG4105RID UPF0379 protein yhcN HVX61_20620 ENOG4105UNR (Barnase) inhibitor HVX61_20635 ENOG4105ZQC membrane protein AaeX HVX61_20640 ENOG4105CR8 Transcriptional regulator HVX61_20645 ENOG4105D1U peptidase U62 modulator of DNA gyrase HVX61_20650 ENOG4105QD6 exported protein HVX61_20655 ENOG4105C03 ribonuclease HVX61_20665 ENOG4105VQ7 Rod shape-determining protein MreD HVX61_20670 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) HVX61_20680 ENOG41062P1 Diguanylate cyclase phosphodiesterase HVX61_20685 ENOG4105D3Z quinone oxidoreductase, yhdh yhfp family HVX61_20690 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein HVX61_20695 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase HVX61_20700 ENOG4105RG0 Membrane HVX61_20705 ENOG4108IA2 Sodium pantothenate symporter HVX61_20715 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) HVX61_20725 ENOG4105CEC DNA methylase N-4 N-6 HVX61_20730 ENOG41061ME transport protein HVX61_20735 ENOG4108XG4 DNA-binding transcriptional regulator HVX61_20740 ENOG4105C1P efflux transporter, rnd family, mfp subunit HVX61_20745 ENOG4105BZS acriflavin resistance protein HVX61_20750 ENOG4105XCM membrane LIPOPROTEIN HVX61_20760 ENOG4105EZ7 amino acid ABC transporter HVX61_20765 ENOG4105DRP amino acid AbC transporter HVX61_20770 ENOG4105CDA abc transporter atp-binding protein HVX61_20810 ENOG4108Z0R Transferase HVX61_20815 ENOG4105SG3 Protein of unknown function (DUF1488) HVX61_20820 ENOG4105E2X shikimate dehydrogenase HVX61_20825 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) HVX61_20830 ENOG4108WI1 Dna topoisomerase HVX61_20840 ENOG4105C79 DNA protecting protein DprA HVX61_20860 ENOG4105C1A potassium transporter peripheral membrane HVX61_20870 ENOG4105VCN Rescues the ribosomes stalled at the 3' end of non-stop mRNAs. May induce hydrolysis of the ribosome-bound peptidyl-tRNA. This activity is crucial when the stalled ribosome can not be rescued by the SsrA(tmRNA)-SmpB quality control system HVX61_20875 ENOG4105W1Y Transcriptional regulator HVX61_20880 ENOG4105VTS DnaJ-like, subfamily C HVX61_20910 ENOG41067V7 50S ribosomal protein L36 HVX61_20915 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) HVX61_20960 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) HVX61_21005 ENOG41080KG One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) HVX61_21030 ENOG4108UQY Iron-storage protein HVX61_21035 ENOG4105W53 bacterioferritin-associated ferredoxin HVX61_21060 ENOG4105YKK Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions (By similarity) HVX61_21075 ENOG4105WWK YheO domain protein HVX61_21080 ENOG4108V1T peptidylprolyl cis-trans isomerase HVX61_21090 ENOG4108YZY peptidylprolyl cis-trans isomerase HVX61_21095 ENOG4105VKU nucleicacid-binding protein HVX61_21110 ENOG4105C5H ABC transporter HVX61_21115 ENOG4105DNZ Alpha Beta Hydrolase HVX61_21125 ENOG4105CJE phosphoribulokinase (EC 2.7.1.19) HVX61_21130 ENOG4108UKZ OsmC family HVX61_21140 ENOG410613R integral membrane protein, YccS YhfK family HVX61_21145 ENOG4105C8Y Acetylornithine aminotransferase HVX61_21150 ENOG4105DDQ anthranilate synthase HVX61_21155 ENOG4105MZU cell filamentation protein HVX61_21165 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) HVX61_21175 ENOG4107QZF nitrite reductase NADPH large subunit HVX61_21180 ENOG4105WZK nitrite reductase NADPH small subunit HVX61_21185 ENOG4107V9H nitrite transporter HVX61_21195 ENOG4105VYH HVX61_21200 ENOG4107QHQ amino acid HVX61_21205 ENOG4107R1S catalyzes the conversion of fructoselysine 6-phosphate to glucose 6-phosphate and lysine HVX61_21210 ENOG4107Y0V Not clear, may be involved in an isomerization step HVX61_21215 ENOG4108KPW sugar kinase HVX61_21220 ENOG4105FDP GntR family transcriptional regulator HVX61_21225 ENOG4105C31 Tryptophanyl-tRNA synthetase HVX61_21230 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) HVX61_21235 ENOG4105DJV ribulose-phosphate 3-epimerase HVX61_21240 ENOG4105DFE Dna adenine methylase HVX61_21245 ENOG4105EGB membrane protein DamX HVX61_21250 ENOG4105D49 3-dehydroquinate synthase HVX61_21260 ENOG4105E4G Type IV pilus HVX61_21265 ENOG4105ITY Required for the use of extracellular DNA as a nutrient HVX61_21270 ENOG4105XPX DNA utilization protein HofO HVX61_21275 ENOG41065NF Fimbrial assembly family protein HVX61_21280 ENOG4108U1Q Pilus assembly protein HVX61_21285 ENOG4108JQC penicillin-binding protein 1A HVX61_21290 ENOG4107RK2 ADP-ribose diphosphatase NudE HVX61_21295 ENOG4105DQY intracellular growth attenuator HVX61_21300 ENOG4107Y3D HAD-superfamily hydrolase subfamily IA variant 3 HVX61_21305 ENOG4105VEJ Heat shock protein HVX61_21315 ENOG4108MAJ Membrane HVX61_21325 ENOG4105E0F Histidine kinase HVX61_21335 ENOG4108RRZ Transcription elongation factor GreB HVX61_21340 ENOG4105BZM domain protein HVX61_21345 ENOG4105XFK Ferrous iron transport protein A HVX61_21350 ENOG4105CE1 Ferrous iron transport protein b HVX61_21360 ENOG4105DNE Transposase HVX61_21370 ENOG4105MJ2 Competence protein HVX61_21380 ENOG4105C6Z Gluconate HVX61_21385 ENOG4107RTM 4-alpha-glucanotransferase (EC 2.4.1.25) HVX61_21390 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) HVX61_21415 ENOG4105E0Y RtcB Protein HVX61_21420 ENOG4105CYB regulatoR HVX61_21425 ENOG4105E98 transcriptional regulator DeoR family HVX61_21440 ENOG4105C6V Glycerol-3-phosphate dehydrogenase HVX61_21460 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) HVX61_21480 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) HVX61_21485 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) HVX61_21490 ENOG41076UM multiple antibiotic resistance (MarC)-related protein HVX61_21500 ENOG4105C9U ATP-dependent DNA helicase RecQ HVX61_21505 ENOG4105C6Z Gluconate HVX61_21510 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family HVX61_21515 ENOG4105DIQ Transcriptional regulator HVX61_21520 ENOG4105C2I pirin domain protein HVX61_21525 ENOG4105D9R oxidoreductase HVX61_21530 ENOG4105WCN acetyltransferase HVX61_21535 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) HVX61_21540 ENOG4105WC8 Conserved Protein HVX61_21545 ENOG4107T6V glycerophosphoryl diester phosphodiesterase HVX61_21555 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component HVX61_21560 ENOG4105E4X binding-protein-dependent transport systems inner membrane Component HVX61_21565 ENOG4105BZ7 extracellular solute-binding protein family 1 HVX61_21570 ENOG4108IV0 ABC, transporter HVX61_21575 ENOG4105C0Z ABC transporter HVX61_21580 ENOG4105CF8 branched-chain amino acid ABC transporter, permease HVX61_21585 ENOG4105C32 Amino acid ABC transporter (Permease) HVX61_21590 ENOG4105CP9 extracellular ligand-binding receptor HVX61_21595 ENOG4105U59 -acetyltransferase HVX61_21610 ENOG4105CP9 extracellular ligand-binding receptor HVX61_21615 ENOG4105DEK Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HVX61_21620 ENOG4105CRP Part of the ABC transporter FtsEX involved in HVX61_21625 ENOG4105CAK Cell division ATP-binding protein ftsE HVX61_21630 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) HVX61_21635 ENOG4106H78 methyltransferase HVX61_21640 ENOG4105MG3 Membrane HVX61_21650 ENOG4107FS9 Membrane HVX61_21670 ENOG4105EX9 Membrane HVX61_21675 ENOG4108W1V Lipoprotein HVX61_21680 ENOG4105F9N Major Facilitator Superfamily HVX61_21685 ENOG4105DSF transport protein HVX61_21705 ENOG4105E9Q Acyl-transferase HVX61_21735 ENOG4106N3V dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83) HVX61_21760 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) HVX61_21770 ENOG4105C2D reductase HVX61_21775 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) HVX61_21780 ENOG4107YAK holo-(acyl carrier protein) synthase 2 HVX61_21785 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein HVX61_21790 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HVX61_21795 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HVX61_21800 ENOG4106665 Part of the ABC transporter complex NikABCDE involved in nickel import. Responsible for energy coupling to the transport system (By similarity) HVX61_21825 ENOG41090UW PTS System HVX61_21830 ENOG4105DT3 PTS system, galactitol-specific IIc component HVX61_21845 ENOG4105D2N Aldolase HVX61_21860 ENOG4105CMI transporter HVX61_21865 ENOG4105CJ1 ABC, transporter HVX61_21870 ENOG4105D0S secretion protein (HlyD HVX61_21885 ENOG4107UNS conserved inner membrane protein HVX61_21890 ENOG4105CBX hi0933 family HVX61_21895 ENOG4105CJ3 phosphate transporter HVX61_21910 ENOG4105DUX Transporter HVX61_21920 ENOG4105DGW oligopeptidase A HVX61_21925 ENOG4105D6S protein involved in catabolism of external DNA HVX61_21930 ENOG4105DC8 reductase HVX61_21945 ENOG4105KBH arsR family transcriptional regulator HVX61_21950 ENOG4107R5R arsenical pump membrane protein HVX61_21955 ENOG4105K89 arsenate reductase HVX61_21975 ENOG4105Y4Z Outer Membrane Lipoprotein HVX61_21985 ENOG4106QJH hemin transport protein HVX61_21990 ENOG4107ENK receptor HVX61_21995 ENOG4107R4I Periplasmic binding protein HVX61_22000 ENOG4105D4P Coproporphyrinogen iii oxidase HVX61_22005 ENOG41090JE Utilization Protein HVX61_22015 ENOG4105EHG Permease protein HVX61_22020 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) HVX61_22025 ENOG4105KT7 mgtC SapB transporter HVX61_22030 ENOG4105XXV Acid-resistance protein HVX61_22035 ENOG41060V2 Acid-resistance protein HVX61_22040 ENOG4108YK4 Acid-resistance membrane protein HVX61_22045 ENOG4106WJ0 Regulates the expression of several genes involved in acid resistance. Required for the expression of gadA and gadBC, among others, regardless of media or growth conditions. Binds directly to the 20 bp GAD box found in the control regions of both loci HVX61_22055 ENOG4105C1P efflux transporter, rnd family, mfp subunit HVX61_22060 ENOG4105BZS acriflavin resistance protein HVX61_22070 ENOG4108NKV transcriptional regulator HVX61_22075 ENOG4105CVK Glutamate decarboxylase HVX61_22080 ENOG4105CA0 peroxidase HVX61_22090 ENOG4106S2D Transcriptional regulator HVX61_22095 ENOG4105CBN LysR family transcriptional regulator HVX61_22100 ENOG4107H3J ribonuclease HVX61_22105 ENOG4105CSH Transporter HVX61_22110 ENOG41066T0 asmA family HVX61_22115 ENOG4105CMB EAL domain-containing protein HVX61_22125 ENOG4105CS0 peptidase HVX61_22135 ENOG4105BZU Histidine kinase HVX61_22140 ENOG4105EJG cellulose synthase HVX61_22145 ENOG4105K2Z endo-1,4-d-glucanase (EC 3.2.1.4) HVX61_22150 ENOG4107EEX Cellulose synthase regulator protein HVX61_22155 ENOG4107QZ7 Cellulose synthase catalytic subunit HVX61_22165 ENOG410661M cytoplasmic protein HVX61_22170 ENOG4105U74 cellulose biosynthesis protein BcsE HVX61_22175 ENOG4105WQA Cellulose biosynthesis protein BcsF HVX61_22180 ENOG4105D1V cellulose synthase operon protein YhjU HVX61_22205 ENOG4105C44 Serine transporter HVX61_22210 ENOG4108JQ7 (ABC) transporter HVX61_22215 ENOG4105C3U ABC transporter HVX61_22220 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HVX61_22225 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HVX61_22235 ENOG4105DEF Extracellular solute-binding protein, family 5 HVX61_22245 ENOG4105DIJ Phosphoethanolamine transferase HVX61_22250 ENOG4106UCC Fimbrial protein HVX61_22255 ENOG4105MHR Fimbrial protein HVX61_22260 ENOG4105CW0 outer membrane usher protein HVX61_22265 ENOG4108VCD Chaperone HVX61_22270 ENOG4106EAR Fimbrial protein HVX61_22275 ENOG4105FCD Major Facilitator HVX61_22280 ENOG4105EAX Putative lipase HVX61_22285 ENOG4108R3E Dna-3-methyladenine glycosylase i HVX61_22290 ENOG4105HNP -acetyltransferase HVX61_22295 ENOG4107QY8 reductase HVX61_22300 ENOG4108ZG0 Ompa motb domain protein HVX61_22305 ENOG4105C5I Dehydrogenase HVX61_22310 ENOG4106JH6 (LipO)protein HVX61_22315 ENOG4105MVF Transcriptional regulator HVX61_22325 ENOG41060TC Hok gef cell toxic protein HVX61_22345 ENOG4105MEV Acyl-transferase HVX61_22350 ENOG4108Z12 YiaAB two helix domain-containing protein HVX61_22355 ENOG410688U Inner membrane protein yiaB HVX61_22360 ENOG4105CMG Carbohydrate kinase HVX61_22370 ENOG4105DFW ABC transporter HVX61_22380 ENOG4108HWW ABC transporter HVX61_22385 ENOG4105T16 Transcriptional regulator (AraC family) HVX61_22390 ENOG4108UR8 BAX protein HVX61_22395 ENOG4107T9C Alpha amylase catalytic region HVX61_22400 ENOG4105JKW Valine--pyruvate aminotransferase HVX61_22405 ENOG4108XIB electron transport protein ysaA HVX61_22410 ENOG4105J4Q Transcriptional regulator HVX61_22420 ENOG4105CT4 transporter HVX61_22430 ENOG4105GNX MltA-interacting MipA family protein HVX61_22435 ENOG4108Q2M Transcriptional regulator HVX61_22440 ENOG4105EFX secretion protein, HlyD family HVX61_22445 ENOG4105KK7 inner membrane protein YiaW HVX61_22450 ENOG4105C26 Dehydrogenase HVX61_22465 ENOG4105C0A alcohol dehydrogenase HVX61_22470 ENOG4105EM7 Selenocysteine-specific translation elongation factor HVX61_22480 ENOG4108U78 Glutathione S-transferase HVX61_22485 ENOG4108BMY protease HVX61_22530 ENOG4105EFX secretion protein, HlyD family HVX61_22535 ENOG4105FP6 Protein of unknown function (DUF3302) HVX61_22540 ENOG4105CTS PTS system mannitol-specific HVX61_22550 ENOG4105E61 Mannitol repressor protein HVX61_22560 ENOG4108YYI Protein of unknown function (DUF2810) HVX61_22565 ENOG4108WY4 inner membrane lipoprotein HVX61_22570 ENOG4105EUR Domain-Containing protein HVX61_22575 ENOG4105DAA L-lactate HVX61_22580 ENOG41073TP transcriptional regulator HVX61_22590 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) HVX61_22595 ENOG4105D7W serine acetyltransferase HVX61_22610 ENOG4105VW4 glutaredoxin 3 HVX61_22615 ENOG4107YZP Rhodanese domain protein HVX61_22625 ENOG41063SB peptidase HVX61_22630 ENOG4105PXI polysaccharide deacetylase HVX61_22635 ENOG4105K64 Glycosyl transferase, family 2 HVX61_22645 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) HVX61_22655 ENOG4105XA0 heptosyltransferase ii HVX61_22660 ENOG4105D16 lipopolysaccharide heptosyltransferase i HVX61_22665 ENOG41068PG O-Antigen polymerase HVX61_22670 ENOG4105K64 Glycosyl transferase, family 2 HVX61_22675 ENOG4105X1N Glycosyl transferase family 8 HVX61_22685 ENOG4105X1N Glycosyl transferase family 8 HVX61_22690 ENOG4106AH0 Glycosyl Transferase HVX61_22695 ENOG4107543 (lipo)polysaccharide HVX61_22700 ENOG4107RJ7 Glycosyl transferase (Group 1 HVX61_22705 ENOG4105DKP glycosyl transferase, family 9 HVX61_22710 ENOG4105D8A 3-Deoxy-D-manno-octulosonic-acid transferase HVX61_22730 ENOG4105KDC 50s ribosomal protein l28 HVX61_22740 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase HVX61_22745 ENOG4108Z1K This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) HVX61_22755 ENOG4107RRE RNA-directed DNA polymerase HVX61_22770 ENOG4105DSJ YicC domain protein HVX61_22775 ENOG4105F5P DNA-damage-inducible protein d HVX61_22780 ENOG4105EN6 Membrane HVX61_22790 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) HVX61_22800 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) HVX61_22805 ENOG4105FE8 tRNA (Guanosine-2'-O-)-methyltransferase HVX61_22810 ENOG4105CB5 ATP-dependent DNA helicase recG HVX61_22815 ENOG4105D6U Sodium Glutamate Symporter HVX61_22820 ENOG4105C2W permease HVX61_22825 ENOG4105JV1 AsmA family HVX61_22830 ENOG4105CJQ hydrolase, family 31 HVX61_22835 ENOG4105CT4 transporter HVX61_22845 ENOG4105DFP Integrase HVX61_22885 ENOG4105NWR lipid A biosynthesis (Kdo)2-(Lauroyl)-lipid IVA acyltransferase HVX61_22890 ENOG4105DIJ Phosphoethanolamine transferase HVX61_22895 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) HVX61_22900 ENOG4107BJW polysaccharide deacetylase HVX61_22905 ENOG4108ZK4 sdia-regulated domain-containing protein HVX61_22930 ENOG4105TNG K13735 adhesin invasin HVX61_22940 ENOG4108W9T type 1 fimbriae regulatory protein HVX61_22945 ENOG4105E71 FimE is one of the 2 regulatory proteins which control the phase variation of type 1 fimbriae in E.coli. These proteins mediate the periodic inversion of a 300bp DNA segment that harbors the promoter for the fimbrial structural gene, fimA. FimE switches fimA off HVX61_23020 ENOG4105F4K antigen 43 HVX61_23025 ENOG4108F5E vimentin HVX61_23030 ENOG4108YIV HVX61_23050 ENOG4106H6R UPF0380 protein HVX61_23060 ENOG4105MFG Antirestriction protein HVX61_23065 ENOG4108YGG dna repair protein HVX61_23075 ENOG4105MAW Antitoxin component of a toxin-antitoxin (TA) module. Labile antitoxin that counteracts the effect of the CbtA (YeeV) toxin. It does not bind to the cognate toxin but instead binds to MreB and FtsZ (the toxin targets), enhancing their polymerization by forming higher-order bundles HVX61_23105 ENOG4105S8Q sugar efflux transporter HVX61_23110 ENOG4108UZ3 Transporter HVX61_23115 ENOG4105D01 (LipO)protein HVX61_23120 ENOG4105T8A Uncharacterized protein YicS HVX61_23145 ENOG4105IBT Required for translocation of effector proteins via the type III secretion system SPI-1, which is essential for an efficient bacterial internalization. Probably acts by modulating the secretion of SipA, SipB, and SipC HVX61_23150 ENOG4108YAB Invasion protein HVX61_23155 ENOG4105TNG K13735 adhesin invasin HVX61_23175 ENOG4108SAJ Protein of unknown function (DUF1198) HVX61_23180 ENOG4105C7N Xanthine uracil vitamin C permease HVX61_23190 ENOG4105ETE Transcriptional regulator (LacI family HVX61_23200 ENOG4105CK1 PTS System HVX61_23205 ENOG4105CS2 ec 3.2.1.21 HVX61_23210 ENOG4105VCP PTS System HVX61_23220 ENOG4108SAJ Protein of unknown function (DUF1198) HVX61_23225 ENOG4105CXY transporter HVX61_23230 ENOG4105CXY transporter HVX61_23235 ENOG4105BZU Histidine kinase HVX61_23240 ENOG4108KX4 response regulator HVX61_23255 ENOG4105M71 acetolactate synthase 1 regulatory subunit HVX61_23260 ENOG4105C7K acetolactate synthase HVX61_23275 ENOG4105E5M Multidrug resistance protein D HVX61_23280 ENOG4105J13 transcriptional regulator HVX61_23285 ENOG4105JP4 Inner membrane protein yidG HVX61_23290 ENOG4105VG5 Membrane HVX61_23295 ENOG4106DRA Inner membrane protein YidI HVX61_23300 ENOG4105CBG Sulfatase HVX61_23305 ENOG4107RUZ Sss sodium solute transporter superfamily HVX61_23310 ENOG4108AHD Transcriptional regulator HVX61_23315 ENOG4105F8D glycoside hydrolase family 4 HVX61_23320 ENOG4105CI1 PTS System HVX61_23325 ENOG4105FDP GntR family transcriptional regulator HVX61_23345 ENOG4105R2A (LipO)protein HVX61_23350 ENOG4105D99 atp gtp-binding protein HVX61_23355 ENOG4107WAP fad NAD(P)-binding domain HVX61_23360 ENOG410657R replicase EC 2.7 HVX61_23365 ENOG410667J hydrolase HVX61_23370 ENOG4105VP5 Bacterial protein of unknown function (DUF937) HVX61_23375 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HVX61_23385 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) HVX61_23400 ENOG4105VG0 50S ribosomal protein l34 HVX61_23415 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins HVX61_23440 ENOG4108P6C Tryptophan transporter of low affinity HVX61_23455 ENOG4105E8Q phosphopantetheinyl transferase HVX61_23460 ENOG4108YYH Nadph-dependent fmn reductase HVX61_23465 ENOG4105C7N Xanthine uracil vitamin C permease HVX61_23470 ENOG4107UB3 HAD-superfamily hydrolase subfamily IA variant 3 HVX61_23495 ENOG4108UTW Plays a role in the regulation of phosphate uptake HVX61_23500 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) HVX61_23505 ENOG4105E2Z phosphate ABC transporter (Permease HVX61_23510 ENOG4105C8U phosphate abc transporter HVX61_23515 ENOG4107QMV Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity) HVX61_23520 ENOG4108M66 Involved in regulation of length and mediation of adhesion of SfmA fimbriae (but not necessary for the production of fimbriae). Seems to be mannose binding adhesin (By similarity) HVX61_23525 ENOG4105I74 Fimbrial protein HVX61_23530 ENOG4105CW0 outer membrane usher protein HVX61_23535 ENOG4108VCD Chaperone HVX61_23540 ENOG4108ZI2 Fimbrial protein HVX61_23545 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) HVX61_23595 ENOG4105GXX Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit I associates with the membrane and may be involved with cation translocation HVX61_23610 ENOG4105QTB Flavodoxin HVX61_23615 ENOG4108VVK transcriptional Regulator, AsnC HVX61_23625 ENOG4105EV2 VWA domain protein interacting with AAA ATPase HVX61_23645 ENOG4105C2J ABC transporter HVX61_23650 ENOG4105CNN ABC, transporter HVX61_23655 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator HVX61_23660 ENOG4108RVA ribokinase HVX61_23665 ENOG4105ETE Transcriptional regulator (LacI family HVX61_23670 ENOG4105C0R drug resistance transporter emrb qaca subfamily HVX61_23675 ENOG4107EJG GntR family transcriptional regulator HVX61_23715 ENOG4108WFC UPF0438 protein yifE HVX61_23720 ENOG4105C0P Mg chelatase subunit ChlI HVX61_23740 ENOG4105P3Y Acetolactate synthase 2 regulatory subunit HVX61_23745 ENOG4105CM2 brancheD-chain amino acid aminotransferase HVX61_23755 ENOG4105C7B Threonine dehydratase HVX61_23760 ENOG4105EMY transcriptional regulator HVX61_23770 ENOG4105KQ5 peptidylprolyl cis-trans isomerase HVX61_23780 ENOG4105C4R Atp-dependent dna helicase HVX61_23805 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) HVX61_23810 ENOG4105ESV Glycosyl transferase, family 4 HVX61_23815 ENOG4105SFE lipopolysaccharide biosynthesis protein HVX61_23820 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase HVX61_23825 ENOG4107QQG Dehydrogenase HVX61_23830 ENOG4105C1B dTDP-glucose 4-6-dehydratase HVX61_23835 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) HVX61_23840 ENOG4108WJ1 acetyltransferase HVX61_23845 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase HVX61_23850 ENOG4105EGZ biosynthesis protein HVX61_23870 ENOG4105C85 amino acid HVX61_23895 ENOG4105C4X radical SAM domain protein HVX61_23900 ENOG4105ENH Sulfatase HVX61_23905 ENOG410601J HemY protein HVX61_23910 ENOG4105ECF c-methyltransferase HVX61_23915 ENOG41076E6 Uroporphyrinogen-III Synthase HVX61_23920 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) HVX61_23925 ENOG4107T0K Adenylate cyclase HVX61_23955 ENOG4105S7Z (LipO)protein HVX61_23965 ENOG4105CT0 Protein of unknown function, DUF484 HVX61_23975 ENOG4105DFC had-superfamily hydrolase, subfamily ia, variant HVX61_23980 ENOG4105C4R Atp-dependent dna helicase HVX61_23985 ENOG4107V4F S-adenosyl-l-methionine hydroxide adenosyltransferase HVX61_23990 ENOG4108T58 Mg2 transport protein CorA HVX61_23995 ENOG4107QUT magnesium and cobalt transport protein CorA HVX61_24000 ENOG4105NRM Membrane HVX61_24005 ENOG4106WR8 Inner membrane protein YigG HVX61_24010 ENOG4105FR1 rard protein HVX61_24015 ENOG4108VUY thioesterase Superfamily protein HVX61_24020 ENOG4105HDD phospholipase HVX61_24025 ENOG4105C9U ATP-dependent DNA helicase RecQ HVX61_24030 ENOG4105CCF Lysine exporter protein (Lyse ygga) HVX61_24040 ENOG410829K Lysine exporter protein (Lyse ygga) HVX61_24045 ENOG4108EUD Lysophospholipase HVX61_24050 ENOG4105DQF Hydrolase HVX61_24055 ENOG4105EMK carboxylate amino acid amine transporter HVX61_24060 ENOG4105DZ2 Transcriptional regulator HVX61_24070 ENOG4105CDZ Carboxymethylenebutenolidase (EC 3.1.1.45) HVX61_24075 ENOG4108I5U Uridine phosphorylase HVX61_24080 ENOG4105CGY Dna recombination protein HVX61_24090 ENOG4105JC1 sterol-binding domain protein HVX61_24100 ENOG4105WKS Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) HVX61_24105 ENOG4105X8U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity) HVX61_24110 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) HVX61_24120 ENOG4105MDZ Transcriptional activator rfaH HVX61_24125 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) HVX61_24130 ENOG4108EX3 reductase HVX61_24150 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein HVX61_24155 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) HVX61_24160 ENOG4108RR8 protoporphyrinogen oxidase HVX61_24190 ENOG4105FNP Molybdopterin-guanine dinucleotide biosynthesis protein b HVX61_24195 ENOG4105C6R Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) HVX61_24200 ENOG4105PC1 Conserved Protein HVX61_24205 ENOG4105E27 serine threonine protein kinase HVX61_24210 ENOG4108Z33 Thiol disulfide Interchange Protein HVX61_24220 ENOG4106HNH Acyl-transferase HVX61_24225 ENOG4105C2M dna polymerase I HVX61_24235 ENOG4105ZR3 A GTPase-activating protein (GAP) that modifies Der EngA GTPase function. May play a role in ribosome biogenesis (By similarity) HVX61_24240 ENOG4105D4P Coproporphyrinogen iii oxidase HVX61_24245 ENOG4106FIY HVX61_24250 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family HVX61_24255 ENOG4105CUX Signal transduction histidine kinase HVX61_24260 ENOG4105C5F glutamine synthetase HVX61_24265 ENOG4105CI3 gtp-binding protein typa HVX61_24270 ENOG4108K85 Transcriptional regulator HVX61_24275 ENOG4108KHF Resistance protein HVX61_24280 ENOG4105R9B Major Facilitator HVX61_24290 ENOG4105EJU HAD-superfamily hydrolase subfamily IA variant 3 HVX61_24305 ENOG4105SUU thioesterase domain HVX61_24320 ENOG4105W2W Cytotoxic translational repressor of toxin-antitoxin stability system HVX61_24335 ENOG41068KX affects formate dehydrogenase-N HVX61_24345 ENOG4108MG3 formate dehydrogenase HVX61_24350 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein HVX61_24365 ENOG4108V87 frv operon regulatory protein HVX61_24370 ENOG4106C3V frv operon regulatory protein HVX61_24375 ENOG4105CN9 Peptidase m42 family protein HVX61_24380 ENOG4105DM4 PTS System HVX61_24385 ENOG41064BA PTS system, fructose-specific, IIA component HVX61_24420 ENOG4108BRW Activates expression of the rhaSR operon in response to L-rhamnose (By similarity) HVX61_24430 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) HVX61_24440 ENOG4108RPX mosc domain containing protein HVX61_24445 ENOG4105E0F Histidine kinase HVX61_24450 ENOG4105E3W Two component transcriptional regulator (Winged helix family HVX61_24455 ENOG4105FMW periplasmic HVX61_24460 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HVX61_24605 ENOG4106CQM replication HVX61_24615 ENOG4107AVE This protein is involved in the determination of copy number in gene replication. It binds to the repA promoter thus inhibiting the synthesis of the mRNA for the initiator protein repA (By similarity) HVX61_24640 ENOG4107CBI conjugal transfer fertility inhibition protein HVX61_24660 ENOG4105M0J Toxic component of a toxin-antitoxin (TA) module. A HVX61_24895 ENOG41073YN Protein of unknown function (DUF1380) HVX61_24955 ENOG4106PHM regulatory protein HVX61_24985 ENOG4105BZV Phosphoadenosine phosphosulfate reductase HVX61_24990 ENOG4105GTN ParB Domain Protein Nuclease