locus-tag	class	description
HVX61_00025	COG4695	Portal protein
HVX61_00115	COG5301	cellulose 1,4-beta-cellobiosidase activity
HVX61_00115	COG5301	cellulose 1,4-beta-cellobiosidase activity
HVX61_00190	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
HVX61_00210	COG3152	Membrane
HVX61_00215	COG3691	Protein conserved in bacteria
HVX61_00220	COG0589	response to stress
HVX61_00230	COG1494	fructose-1,6-bisphosphatase
HVX61_00240	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HVX61_00265	COG1575	Belongs to the MenA family. Type 1 subfamily
HVX61_00280	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HVX61_00285	COG1609	Transcriptional regulator
HVX61_00290	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HVX61_00300	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
HVX61_00310	COG0626	cystathionine gamma-synthase activity
HVX61_00315	COG0527	aspartate kinase activity
HVX61_00315	COG0460	homoserine dehydrogenase
HVX61_00320	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HVX61_00330	COG0697	spore germination
HVX61_00335	COG3738	Protein conserved in bacteria
HVX61_00340	COG0371	Dehydrogenase
HVX61_00345	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HVX61_00350	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HVX61_00350	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HVX61_00350	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HVX61_00355	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HVX61_00360	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HVX61_00365	COG1882	Formate acetyltransferase
HVX61_00370	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HVX61_00375	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HVX61_00380	COG2207	Transcriptional regulator
HVX61_00385	COG2194	sulfuric ester hydrolase activity
HVX61_00400	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HVX61_00415	COG0583	DNA-binding transcription factor activity
HVX61_00425	COG1473	amidohydrolase
HVX61_00430	COG0477	Major facilitator Superfamily
HVX61_00435	COG1309	transcriptional regulator
HVX61_00445	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HVX61_00450	COG4206	TonB-dependent receptor
HVX61_00455	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HVX61_00485	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
HVX61_00485	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
HVX61_00520	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HVX61_00525	COG0250	Participates in transcription elongation, termination and antitermination
HVX61_00565	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HVX61_00575	COG2104	thiamine diphosphate biosynthetic process
HVX61_00580	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HVX61_00615	COG3068	Protein conserved in bacteria
HVX61_00630	COG3678	ATP-independent chaperone mediated protein folding
HVX61_00635	COG4191	Histidine kinase
HVX61_00640	COG2204	response regulator
HVX61_00645	COG0151	Belongs to the GarS family
HVX61_00685	COG0456	acetyltransferase
HVX61_00695	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
HVX61_00700	COG2224	Isocitrate lyase
HVX61_00715	COG1414	Transcriptional regulator
HVX61_00720	COG0646	methionine synthase
HVX61_00720	COG1410	methionine synthase
HVX61_00725	COG1283	sodium-dependent phosphate transmembrane transporter activity
HVX61_00770	COG1187	pseudouridine synthase activity
HVX61_00780	COG0527	aspartate kinase activity
HVX61_00805	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HVX61_00820	COG2814	Major facilitator Superfamily
HVX61_00820	COG0477	Major facilitator Superfamily
HVX61_00825	COG3833	ABC-type maltose transport systems, permease component
HVX61_00830	COG1175	transmembrane transport
HVX61_00835	COG2182	Extracellular solute-binding protein
HVX61_00840	COG3842	ATPase activity
HVX61_00855	COG1357	PFAM Pentapeptide repeats (8 copies)
HVX61_00875	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HVX61_00885	COG0534	Mate efflux family protein
HVX61_00890	COG3237	CsbD-like
HVX61_00895	COG0735	belongs to the Fur family
HVX61_00905	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HVX61_00915	COG0604	alcohol dehydrogenase
HVX61_00920	COG0305	Participates in initiation and elongation during chromosome replication
HVX61_00925	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HVX61_00930	COG1448	Aminotransferase
HVX61_00940	COG3700	Belongs to the class B bacterial acid phosphatase family
HVX61_00945	COG0432	Pfam Uncharacterised protein family UPF0047
HVX61_00950	COG2315	Protein conserved in bacteria
HVX61_00955	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HVX61_00960	COG0629	single-stranded DNA binding
HVX61_00970	COG4943	cyclic-guanylate-specific phosphodiesterase activity
HVX61_00975	COG2207	Transcriptional regulator
HVX61_00980	COG0789	Transcriptional regulator
HVX61_00985	COG2252	PERMEase
HVX61_00990	COG0025	NhaP-type Na H and K H
HVX61_00995	COG1357	PFAM Pentapeptide repeats (8 copies)
HVX61_01005	COG3162	membrane
HVX61_01010	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HVX61_01020	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
HVX61_01025	COG0437	4 iron, 4 sulfur cluster binding
HVX61_01030	COG3301	Polysulphide reductase, NrfD
HVX61_01035	COG1138	Cytochrome C-type biogenesis protein
HVX61_01040	COG3088	subunit of a heme lyase
HVX61_01045	COG4235	cytochrome complex assembly
HVX61_01050	COG1301	dicarboxylic acid transport
HVX61_01055	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
HVX61_01070	COG1289	transmembrane transporter activity
HVX61_01075	COG1566	PFAM secretion protein HlyD family protein
HVX61_01085	COG2015	COG2015, Alkyl sulfatase and related hydrolases
HVX61_01095	COG2870	Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno- heptose
HVX61_01095	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HVX61_01115	COG1172	Belongs to the binding-protein-dependent transport system permease family
HVX61_01120	COG1129	ABC transporter
HVX61_01135	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
HVX61_01140	COG0456	acetyltransferase
HVX61_01145	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
HVX61_01150	COG3454	Phosphonate metabolism
HVX61_01155	COG4778	phosphonate C-P lyase system protein PhnL
HVX61_01160	COG4107	phosphonate C-P lyase system protein PhnK
HVX61_01165	COG3627	carbon phosphorus lyase activity
HVX61_01170	COG3626	phosphonate metabolism
HVX61_01175	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
HVX61_01180	COG3624	Phosphonate C-P lyase system protein PhnG
HVX61_01185	COG2188	Transcriptional regulator
HVX61_01190	COG3639	organic phosphonate transmembrane transporter activity
HVX61_01195	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
HVX61_01205	COG2764	glyoxalase bleomycin resistance protein dioxygenase
HVX61_01210	COG2824	Alkylphosphonate utilization operon protein PhnA
HVX61_01225	COG0477	Major facilitator Superfamily
HVX61_01235	COG0642	Histidine kinase
HVX61_01240	COG0745	RESPONSE REGULATOR receiver
HVX61_01245	COG2194	sulfuric ester hydrolase activity
HVX61_01250	COG0531	amino acid
HVX61_01255	COG2207	Transcriptional regulator
HVX61_01260	COG1982	Orn Lys Arg decarboxylase major
HVX61_01265	COG2169	Transcriptional regulator
HVX61_01270	COG1486	melibiose metabolic process
HVX61_01275	COG2211	Major facilitator Superfamily
HVX61_01280	COG3647	Membrane
HVX61_01285	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
HVX61_01285	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HVX61_01290	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HVX61_01295	COG4565	transcriptional regulatory protein
HVX61_01300	COG3290	protein histidine kinase activity
HVX61_01305	COG3592	Divergent 4Fe-4S mono-cluster
HVX61_01310	COG2388	GCN5-related N-acetyl-transferase
HVX61_01325	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HVX61_01330	COG3104	oligopeptide transport
HVX61_01335	COG1982	Orn Lys Arg decarboxylase major
HVX61_01340	COG0531	amino acid
HVX61_01345	COG3710	Transcriptional regulator
HVX61_01355	COG1309	transcriptional regulator
HVX61_01370	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HVX61_01375	COG1027	Aspartate ammonia-lyase
HVX61_01380	COG3030	protein affecting phage T7 exclusion by the F plasmid
HVX61_01385	COG0531	amino acid
HVX61_01410	COG1509	lysine 2,3-aminomutase activity
HVX61_01420	COG5510	response to toxic substance
HVX61_01425	COG5510	response to toxic substance
HVX61_01430	COG2076	Multidrug Resistance protein
HVX61_01435	COG3040	lipid binding
HVX61_01440	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HVX61_01455	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HVX61_01460	COG1053	succinate dehydrogenase
HVX61_01470	COG0531	amino acid
HVX61_01475	COG1511	domain protein
HVX61_01475	COG3264	Mechanosensitive ion channel
HVX61_01520	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HVX61_01520	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HVX61_01525	COG0802	atpase or kinase
HVX61_01530	COG0860	N-Acetylmuramoyl-L-alanine amidase
HVX61_01550	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HVX61_01555	COG0330	HflC and HflK could
HVX61_01560	COG0330	HflC and HflK could
HVX61_01565	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
HVX61_01580	COG0557	exoribonuclease II activity
HVX61_01585	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HVX61_01590	COG3789	protein conserved in bacteria
HVX61_01595	COG1842	Phage shock protein A
HVX61_01605	COG3766	membrane
HVX61_01610	COG5463	Belongs to the UPF0441 family
HVX61_01615	COG0754	glutathionylspermidine amidase activity
HVX61_01620	COG1960	acyl-CoA dehydrogenase activity
HVX61_01630	COG3650	response to hydrogen peroxide
HVX61_01635	COG1073	alpha beta
HVX61_01650	COG3037	sugar-specific permease SgaT UlaA
HVX61_01655	COG3414	Phosphotransferase system galactitol-specific IIB component
HVX61_01660	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HVX61_01695	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HVX61_01720	COG0675	Transposase, IS605 OrfB family
HVX61_01730	COG3061	Opacity-associated protein A
HVX61_01735	COG0545	Peptidyl-prolyl cis-trans isomerase
HVX61_01740	COG1113	amino acid transport
HVX61_01750	COG0697	spore germination
HVX61_01755	COG0702	epimerase
HVX61_01760	COG1733	regulation of RNA biosynthetic process
HVX61_01765	COG0737	Belongs to the 5'-nucleotidase family
HVX61_01770	COG1218	3'(2'),5'-bisphosphate nucleotidase
HVX61_01780	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
HVX61_01790	COG1253	flavin adenine dinucleotide binding
HVX61_01800	COG0729	surface antigen
HVX61_01805	COG2911	Protein conserved in bacteria
HVX61_01810	COG2105	PFAM AIG2 family protein
HVX61_01815	COG2336	PFAM SpoVT AbrB
HVX61_01820	COG2337	Toxic component of a toxin-antitoxin (TA) module
HVX61_01825	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HVX61_01830	COG1879	ABC-type sugar transport system periplasmic component
HVX61_01835	COG1129	ABC transporter
HVX61_01840	COG1172	Belongs to the binding-protein-dependent transport system permease family
HVX61_01845	COG1172	Belongs to the binding-protein-dependent transport system permease family
HVX61_01855	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HVX61_01865	COG0312	modulator of DNA gyrase
HVX61_01870	COG3783	Cytochrome b(562)
HVX61_01875	COG0602	queuosine metabolic process
HVX61_01880	COG1328	CTP reductase activity
HVX61_01885	COG0366	Alpha amylase catalytic
HVX61_01890	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HVX61_01890	COG1263	PTS System
HVX61_01895	COG1609	Transcriptional regulator
HVX61_01905	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HVX61_01910	COG0251	oxidation-reduction process
HVX61_01930	COG0251	oxidation-reduction process
HVX61_01935	COG1028	Short-chain dehydrogenase reductase Sdr
HVX61_01940	COG1309	transcriptional regulator
HVX61_01945	COG2731	YhcH YjgK YiaL family protein
HVX61_01960	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
HVX61_01965	COG0456	acetyltransferase
HVX61_01970	COG4269	membrane
HVX61_01980	COG2927	DNA polymerase III (CHI subunit)
HVX61_01990	COG0795	lipopolysaccharide-transporting ATPase activity
HVX61_01995	COG0795	lipopolysaccharide-transporting ATPase activity
HVX61_02000	COG0433	COG0433 Predicted ATPase
HVX61_02005	COG1064	alcohol dehydrogenase
HVX61_02035	COG1401	restriction endodeoxyribonuclease activity
HVX61_02065	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
HVX61_02070	COG0582	viral genome integration into host DNA
HVX61_02075	COG4974	Belongs to the 'phage' integrase family
HVX61_02080	COG3539	Fimbrial protein
HVX61_02085	COG3539	Fimbrial protein
HVX61_02090	COG3121	Chaperone
HVX61_02095	COG3188	usher protein
HVX61_02100	COG3539	Fimbrial protein
HVX61_02105	COG3539	Fimbrial protein
HVX61_02110	COG3539	Fimbrial protein
HVX61_02115	COG2610	gluconate transmembrane transporter activity
HVX61_02125	COG0246	Mannitol dehydrogenase
HVX61_02130	COG2186	Transcriptional regulator
HVX61_02155	COG0583	DNA-binding transcription factor activity
HVX61_02160	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HVX61_02165	COG0700	Nucleoside recognition
HVX61_02170	COG3366	ferrous iron transmembrane transporter activity
HVX61_02180	COG1388	LysM domain
HVX61_02180	COG1470	cell adhesion involved in biofilm formation
HVX61_02185	COG0477	Major facilitator Superfamily
HVX61_02190	COG3204	pilus organization
HVX61_02205	COG1924	4 iron, 4 sulfur cluster binding
HVX61_02210	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
HVX61_02215	COG2733	membrane
HVX61_02220	COG2814	Major facilitator Superfamily
HVX61_02230	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HVX61_02235	COG5457	Domain of unknown function (DUF1127)
HVX61_02255	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
HVX61_02280	COG0523	cobalamin synthesis protein
HVX61_02285	COG2879	small protein
HVX61_02290	COG1966	Carbon starvation protein
HVX61_02295	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HVX61_02300	COG2368	4-hydroxyphenylacetate
HVX61_02320	COG3971	2-oxopent-4-enoate hydratase activity
HVX61_02330	COG3384	dioxygenase
HVX61_02335	COG1012	belongs to the aldehyde dehydrogenase family
HVX61_02340	COG0179	Fumarylacetoacetate (FAA) hydrolase
HVX61_02345	COG1846	Transcriptional regulator
HVX61_02350	COG0840	transmembrane signaling receptor activity
HVX61_02355	COG2271	Major facilitator Superfamily
HVX61_02360	COG1802	Transcriptional regulator
HVX61_02365	COG1063	alcohol dehydrogenase
HVX61_02380	COG1484	DNA-dependent DNA replication
HVX61_02395	COG2966	Psort location CytoplasmicMembrane, score
HVX61_02400	COG2197	response regulator
HVX61_02405	COG2197	response regulator
HVX61_02410	COG4114	ferric iron reductase
HVX61_02440	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
HVX61_02445	COG0456	acetyltransferase
HVX61_02450	COG1011	Hydrolase
HVX61_02460	COG2823	Periplasmic or secreted lipoprotein
HVX61_02470	COG4667	esterase of the alpha-beta hydrolase superfamily
HVX61_02475	COG0084	hydrolase, TatD family'
HVX61_02480	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HVX61_02485	COG1328	CTP reductase activity
HVX61_02520	COG3726	membrane protein affecting hemolysin expression
HVX61_02525	COG0560	Phosphoserine phosphatase
HVX61_02530	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HVX61_02535	COG1056	cytidyltransferase-related domain
HVX61_02535	COG3172	ATPase kinase involved in NAD metabolism
HVX61_02540	COG1902	pentaerythritol trinitrate reductase activity
HVX61_02555	COG1028	Short-chain dehydrogenase reductase Sdr
HVX61_02565	COG0583	DNA-binding transcription factor activity
HVX61_02570	COG0488	(ABC) transporter
HVX61_02575	COG0741	lytic transglycosylase activity
HVX61_02595	COG3708	Transcriptional regulator
HVX61_02595	COG2207	Transcriptional regulator
HVX61_02600	COG3045	CreA protein
HVX61_02605	COG0745	RESPONSE REGULATOR receiver
HVX61_02610	COG2205	protein histidine kinase activity
HVX61_02615	COG4452	Inner membrane protein CreD
HVX61_02620	COG0745	RESPONSE REGULATOR receiver
HVX61_02630	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
HVX61_02645	COG0527	aspartate kinase activity
HVX61_02645	COG0460	homoserine dehydrogenase
HVX61_02655	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HVX61_02670	COG1115	amino acid carrier protein
HVX61_02675	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HVX61_02680	COG0521	Mo-molybdopterin cofactor biosynthetic process
HVX61_02685	COG1584	GPR1 FUN34 yaaH family protein
HVX61_02690	COG4735	regulation of single-species biofilm formation
HVX61_02720	COG0583	DNA-binding transcription factor activity
HVX61_02730	COG3188	usher protein
HVX61_02735	COG3121	Chaperone
HVX61_02770	COG0196	riboflavin kinase activity
HVX61_02785	COG1047	Peptidyl-prolyl cis-trans
HVX61_02805	COG0505	Belongs to the CarA family
HVX61_02810	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HVX61_02860	COG0644	oxidoreductase
HVX61_02865	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
HVX61_02870	COG2271	Major facilitator Superfamily
HVX61_02885	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HVX61_02920	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HVX61_02930	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
HVX61_02935	COG1357	PFAM Pentapeptide repeats (8 copies)
HVX61_02945	COG0564	pseudouridine synthase activity
HVX61_02955	COG0417	DNA replication proofreading
HVX61_02960	COG0235	Class ii aldolase
HVX61_02975	COG4977	sequence-specific DNA binding
HVX61_02980	COG0586	Pfam SNARE associated Golgi protein
HVX61_02990	COG1178	ABC-type Fe3 transport system permease component
HVX61_02995	COG4143	(ABC) transporter
HVX61_03005	COG4533	DNA binding
HVX61_03030	COG0473	3-isopropylmalate dehydrogenase activity
HVX61_03045	COG0583	DNA-binding transcription factor activity
HVX61_03050	COG0028	Belongs to the TPP enzyme family
HVX61_03055	COG0440	acetolactate synthase activity
HVX61_03065	COG1609	Transcriptional regulator
HVX61_03080	COG3116	cell division
HVX61_03085	COG0768	penicillin binding
HVX61_03090	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HVX61_03095	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HVX61_03105	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HVX61_03110	COG0772	Belongs to the SEDS family
HVX61_03125	COG1181	Belongs to the D-alanine--D-alanine ligase family
HVX61_03130	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
HVX61_03135	COG0849	cell division
HVX61_03140	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HVX61_03160	COG0494	nUDIX hydrolase
HVX61_03175	COG0237	dephospho-CoA kinase activity
HVX61_03190	COG1459	type II secretion system
HVX61_03195	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HVX61_03200	COG4969	Belongs to the N-Me-Phe pilin family
HVX61_03205	COG0157	Belongs to the NadC ModD family
HVX61_03210	COG3023	N-Acetylmuramoyl-L-alanine amidase
HVX61_03215	COG3725	Membrane protein required for beta-lactamase induction
HVX61_03225	COG2186	Transcriptional regulator
HVX61_03230	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
HVX61_03235	COG0508	dehydrogenase complex catalyzes the overall conversion of
HVX61_03240	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HVX61_03245	COG3064	Membrane
HVX61_03250	COG1049	propionate catabolic process, 2-methylcitrate cycle
HVX61_03275	COG2132	Multicopper oxidase
HVX61_03280	COG4993	Dehydrogenase
HVX61_03285	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
HVX61_03290	COG0288	reversible hydration of carbon dioxide
HVX61_03295	COG1131	(ABC) transporter
HVX61_03300	COG0842	Transport permease protein
HVX61_03305	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HVX61_03310	COG0726	polysaccharide deacetylase
HVX61_03320	COG5464	transposase or invertase
HVX61_03345	COG3539	Fimbrial protein
HVX61_03350	COG3539	Fimbrial protein
HVX61_03355	COG3188	usher protein
HVX61_03360	COG3121	Chaperone
HVX61_03370	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HVX61_03375	COG0617	tRNA 3'-terminal CCA addition
HVX61_03380	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HVX61_03385	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HVX61_03395	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
HVX61_03400	COG1643	Atp-dependent helicase
HVX61_03405	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HVX61_03410	COG4774	siderophore transport
HVX61_03415	COG1120	ATPase activity
HVX61_03420	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HVX61_03425	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HVX61_03450	COG2860	membrane
HVX61_03455	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HVX61_03470	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HVX61_03475	COG3835	regulator
HVX61_03495	COG0024	Methionine aminopeptidase
HVX61_03520	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HVX61_03525	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HVX61_03530	COG0575	Belongs to the CDS family
HVX61_03535	COG0750	zinc metalloprotease
HVX61_03545	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
HVX61_03550	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HVX61_03575	COG0587	DNA-directed DNA polymerase activity
HVX61_03590	COG0346	lactoylglutathione lyase activity
HVX61_03595	COG0037	tRNA processing
HVX61_03600	COG4568	rho-dependent transcription termination
HVX61_03610	COG4681	YaeQ
HVX61_03615	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
HVX61_03620	COG3015	lipoprotein NlpE involved in copper resistance
HVX61_03630	COG0791	NLP P60 protein
HVX61_03640	COG1720	tRNA m6t6A37 methyltransferase activity
HVX61_03650	COG1464	Belongs to the NlpA lipoprotein family
HVX61_03655	COG2011	ABC-type metal ion transport system permease component
HVX61_03660	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HVX61_03665	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HVX61_03700	COG0656	L-ascorbic acid biosynthetic process
HVX61_03705	COG0583	DNA-binding transcription factor activity
HVX61_03715	COG2226	methyltransferase
HVX61_03720	COG0741	lytic transglycosylase activity
HVX61_03720	COG1388	LysM domain
HVX61_03730	COG2226	methyltransferase
HVX61_03740	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HVX61_03835	COG3501	Rhs element vgr protein
HVX61_03890	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HVX61_03900	COG1960	acyl-CoA dehydrogenase activity
HVX61_03910	COG0121	glutamine amidotransferase
HVX61_03915	COG3034	peptidoglycan biosynthetic process
HVX61_03920	COG3041	Addiction module toxin RelE StbE family
HVX61_03925	COG3077	Addiction module antitoxin, RelB DinJ family
HVX61_03930	COG0791	NLP P60 protein
HVX61_03935	COG1943	Transposase
HVX61_03955	COG1987	bacterial-type flagellum assembly
HVX61_03980	COG1677	Flagellar hook-basal body complex protein FliE
HVX61_03990	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HVX61_04010	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HVX61_04050	COG1815	bacterial-type flagellum-dependent cell motility
HVX61_04055	COG1558	bacterial-type flagellum-dependent cell motility
HVX61_04065	COG1749	Flagellar hook protein flgE
HVX61_04070	COG4787	bacterial-type flagellum-dependent cell motility
HVX61_04075	COG4786	Flagellar basal body rod
HVX61_04100	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HVX61_04115	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HVX61_04120	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
HVX61_04145	COG1191	sigma factor activity
HVX61_04150	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
HVX61_04165	COG0454	-acetyltransferase
HVX61_04170	COG1690	Belongs to the RtcB family
HVX61_04175	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
HVX61_04180	COG2195	Cleaves the N-terminal amino acid of tripeptides
HVX61_04200	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HVX61_04220	COG0582	viral genome integration into host DNA
HVX61_04320	COG0583	DNA-binding transcription factor activity
HVX61_04325	COG4221	oxidoreductase activity
HVX61_04335	COG0583	DNA-binding transcription factor activity
HVX61_04350	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
HVX61_04355	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HVX61_04360	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
HVX61_04365	COG2080	2 iron, 2 sulfur cluster binding
HVX61_04375	COG3477	response to acidic pH
HVX61_04380	COG0727	PFAM Uncharacterised protein family (UPF0153)
HVX61_04395	COG3188	usher protein
HVX61_04435	COG1902	pentaerythritol trinitrate reductase activity
HVX61_04440	COG1073	alpha beta
HVX61_04445	COG0583	DNA-binding transcription factor activity
HVX61_04455	COG0667	Aldo Keto reductase
HVX61_04460	COG0656	L-ascorbic acid biosynthetic process
HVX61_04465	COG1388	LysM domain
HVX61_04465	COG2373	Large extracellular alpha-helical protein
HVX61_04465	COG4932	domain protein
HVX61_04470	COG2207	Transcriptional regulator
HVX61_04470	COG3708	Transcriptional regulator
HVX61_04475	COG0656	L-ascorbic acid biosynthetic process
HVX61_04480	COG3059	membrane
HVX61_04490	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HVX61_04495	COG2207	Transcriptional regulator
HVX61_04500	COG0247	lactate metabolic process
HVX61_04505	COG1139	Iron-sulfur cluster binding protein
HVX61_04510	COG1556	Lactate utilization protein
HVX61_04520	COG3468	outer membrane autotransporter barrel domain protein
HVX61_04535	COG2200	EAL domain
HVX61_04535	COG2771	luxR family
HVX61_04540	COG0582	viral genome integration into host DNA
HVX61_04565	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HVX61_04570	COG2771	luxR family
HVX61_04570	COG2200	EAL domain
HVX61_04575	COG0583	DNA-binding transcription factor activity
HVX61_04585	COG0666	response to abiotic stimulus
HVX61_04595	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HVX61_04600	COG1304	FMN binding
HVX61_04610	COG0549	Belongs to the carbamate kinase family
HVX61_04615	COG0402	S-adenosylhomocysteine deaminase activity
HVX61_04620	COG1064	alcohol dehydrogenase
HVX61_04635	COG1280	lysine exporter protein (LysE YggA)
HVX61_04645	COG3829	transcription factor binding
HVX61_04650	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
HVX61_04655	COG0372	Belongs to the citrate synthase family
HVX61_04660	COG2079	MmgE PrpD family protein
HVX61_04665	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HVX61_04670	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HVX61_04675	COG0402	S-adenosylhomocysteine deaminase activity
HVX61_04680	COG0583	DNA-binding transcription factor activity
HVX61_04685	COG0288	reversible hydration of carbon dioxide
HVX61_04695	COG2807	transmembrane transport
HVX61_04700	COG0110	maltose O-acetyltransferase activity
HVX61_04705	COG2223	nitrite transmembrane transporter activity
HVX61_04710	COG3250	beta-galactosidase activity
HVX61_04715	COG1609	Transcriptional regulator
HVX61_04725	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HVX61_04730	COG1414	Transcriptional regulator
HVX61_04745	COG0596	Alpha beta hydrolase
HVX61_04765	COG2814	Major facilitator Superfamily
HVX61_04770	COG3122	Protein conserved in bacteria
HVX61_04790	COG3842	ATPase activity
HVX61_04800	COG1840	ABC-type Fe3 transport system, periplasmic component
HVX61_04805	COG2271	Major facilitator Superfamily
HVX61_04820	COG4521	taurine ABC transporter
HVX61_04825	COG4525	Part of the ABC transporter complex TauABC involved in taurine import. Responsible for energy coupling to the transport system
HVX61_04830	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HVX61_04835	COG2175	clavaminate synthase activity
HVX61_04840	COG0113	porphobilinogen synthase activity
HVX61_04845	COG3468	outer membrane autotransporter barrel domain protein
HVX61_04850	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HVX61_04855	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HVX61_04860	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
HVX61_04880	COG1181	Belongs to the D-alanine--D-alanine ligase family
HVX61_04895	COG1785	Belongs to the alkaline phosphatase family
HVX61_04905	COG3706	GGDEF domain
HVX61_04910	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HVX61_04930	COG4126	flavin adenine dinucleotide binding
HVX61_04955	COG1940	carbohydrate kinase activity
HVX61_04960	COG2814	Major facilitator Superfamily
HVX61_04965	COG0419	ATPase involved in DNA repair
HVX61_04970	COG0420	3'-5' exonuclease activity
HVX61_04975	COG0745	RESPONSE REGULATOR receiver
HVX61_04980	COG5002	protein histidine kinase activity
HVX61_04985	COG1114	Component of the transport system for branched-chain amino acids
HVX61_04990	COG1113	amino acid transport
HVX61_04995	COG0366	Alpha amylase catalytic
HVX61_05020	COG1862	Preprotein translocase
HVX61_05025	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HVX61_05030	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HVX61_05035	COG1403	HNH endonuclease
HVX61_05040	COG3248	Nucleoside-binding outer membrane protein
HVX61_05045	COG4238	major outer membrane lipoprotein
HVX61_05055	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HVX61_05055	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HVX61_05070	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
HVX61_05075	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HVX61_05085	COG0667	Aldo Keto reductase
HVX61_05095	COG0142	geranyltranstransferase activity
HVX61_05110	COG0693	protein deglycase activity
HVX61_05115	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HVX61_05125	COG2814	Major facilitator Superfamily
HVX61_05150	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
HVX61_05155	COG1845	cytochrome c oxidase, subunit III
HVX61_05160	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HVX61_05165	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HVX61_05170	COG2223	nitrite transmembrane transporter activity
HVX61_05175	COG3056	Lipoprotein
HVX61_05180	COG0271	Belongs to the BolA IbaG family
HVX61_05200	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HVX61_05205	COG0776	regulation of translation
HVX61_05210	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HVX61_05215	COG1555	photosystem II stabilization
HVX61_05220	COG0824	Thioesterase
HVX61_05230	COG4533	DNA binding
HVX61_05240	COG1522	sequence-specific DNA binding
HVX61_05245	COG1132	(ABC) transporter
HVX61_05250	COG1132	(ABC) transporter
HVX61_05255	COG0347	Belongs to the P(II) protein family
HVX61_05260	COG0004	ammonium transporteR
HVX61_05265	COG1946	Acyl-CoA thioesterase
HVX61_05270	COG3126	Type III secretion system lipoprotein chaperone (YscW)
HVX61_05275	COG3695	enzyme binding
HVX61_05285	COG5507	3-demethylubiquinone-9 3-methyltransferase
HVX61_05290	COG4943	cyclic-guanylate-specific phosphodiesterase activity
HVX61_05300	COG0110	maltose O-acetyltransferase activity
HVX61_05315	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HVX61_05320	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HVX61_05325	COG1309	transcriptional regulator
HVX61_05330	COG1196	nuclear chromosome segregation
HVX61_05330	COG3264	Mechanosensitive ion channel
HVX61_05340	COG3923	Primosomal replication protein n
HVX61_05345	COG2832	Protein of unknown function (DUF454)
HVX61_05355	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HVX61_05390	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HVX61_05395	COG4651	solute:proton antiporter activity
HVX61_05395	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HVX61_05400	COG2223	nitrite transmembrane transporter activity
HVX61_05405	COG0737	Belongs to the 5'-nucleotidase family
HVX61_05410	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HVX61_05415	COG3735	TraB family
HVX61_05420	COG3093	addiction module antidote protein HigA
HVX61_05425	COG2217	Heavy metal translocating P-type atpase
HVX61_05430	COG2066	Belongs to the glutaminase family
HVX61_05435	COG0531	amino acid
HVX61_05465	COG0789	Transcriptional regulator
HVX61_05490	COG1585	Membrane protein implicated in regulation of membrane protease activity
HVX61_05495	COG0330	HflC and HflK could
HVX61_05500	COG4619	ABC transporter
HVX61_05505	COG0390	transport system, permease component
HVX61_05510	COG3118	belongs to the thioredoxin family
HVX61_05515	COG0300	oxidoreductase activity
HVX61_05520	COG2755	lipolytic protein G-D-S-L family
HVX61_05525	COG4181	ATPase activity
HVX61_05530	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
HVX61_05540	COG0583	DNA-binding transcription factor activity
HVX61_05550	COG1414	Transcriptional regulator
HVX61_05555	COG3960	tartronate-semialdehyde synthase activity
HVX61_05560	COG3622	Belongs to the hyi family
HVX61_05565	COG2084	Dehydrogenase
HVX61_05570	COG1953	Uracil, thiamine, allantoin
HVX61_05580	COG2233	PERMEase
HVX61_05585	COG1929	Belongs to the glycerate kinase type-1 family
HVX61_05590	COG3257	ureidoglycine aminohydrolase activity
HVX61_05595	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HVX61_05600	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
HVX61_05605	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HVX61_05610	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HVX61_05620	COG0549	Belongs to the carbamate kinase family
HVX61_05625	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HVX61_05630	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HVX61_05640	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HVX61_05650	COG1988	membrane-bound metal-dependent
HVX61_05655	COG2501	S4 domain
HVX61_05665	COG3539	Fimbrial protein
HVX61_05670	COG3121	Chaperone
HVX61_05675	COG3188	usher protein
HVX61_05680	COG3539	Fimbrial protein
HVX61_05685	COG3539	Fimbrial protein
HVX61_05690	COG2197	response regulator
HVX61_05700	COG0582	viral genome integration into host DNA
HVX61_05715	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
HVX61_05720	COG5532	Uncharacterized conserved protein (DUF2303)
HVX61_05760	COG1846	Transcriptional regulator
HVX61_05775	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
HVX61_05785	COG1403	HNH endonuclease
HVX61_05805	COG3772	lysozyme
HVX61_05820	COG5562	phage envelope protein
HVX61_05835	COG4220	transposase activity
HVX61_05855	COG1030	water channel activity
HVX61_05905	COG1196	nuclear chromosome segregation
HVX61_05940	COG5301	cellulose 1,4-beta-cellobiosidase activity
HVX61_05945	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
HVX61_05950	COG3546	catalase activity
HVX61_05955	COG3685	Protein conserved in bacteria
HVX61_05960	COG3685	Protein conserved in bacteria
HVX61_05965	COG3729	General stress protein
HVX61_05970	COG0500	methyltransferase
HVX61_05975	COG4571	Outer membrane protease
HVX61_05980	COG2207	Transcriptional regulator
HVX61_05990	COG4783	chaperone-mediated protein folding
HVX61_05995	COG1215	transferase activity, transferring glycosyl groups
HVX61_06000	COG5002	protein histidine kinase activity
HVX61_06005	COG0745	RESPONSE REGULATOR receiver
HVX61_06010	COG1538	Outer membrane efflux protein
HVX61_06015	COG5569	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HVX61_06020	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HVX61_06025	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HVX61_06030	COG1113	amino acid transport
HVX61_06035	COG0668	transmembrane transport
HVX61_06040	COG0778	Nitroreductase
HVX61_06045	COG2315	Protein conserved in bacteria
HVX61_06070	COG2977	Belongs to the P-Pant transferase superfamily
HVX61_06075	COG4771	TonB-dependent receptor
HVX61_06080	COG2382	esterase
HVX61_06085	COG3251	PFAM MbtH domain protein
HVX61_06090	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
HVX61_06090	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HVX61_06095	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
HVX61_06100	COG1120	ATPase activity
HVX61_06105	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HVX61_06110	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HVX61_06120	COG4592	Periplasmic binding protein
HVX61_06125	COG1169	isochorismate synthase
HVX61_06130	COG1021	2,3-dihydroxybenzoate-AMP ligase
HVX61_06135	COG1535	isochorismatase
HVX61_06135	COG3433	isochorismatase activity
HVX61_06140	COG1028	Short-chain dehydrogenase reductase Sdr
HVX61_06145	COG2050	protein possibly involved in aromatic compounds catabolism
HVX61_06150	COG1966	Carbon starvation protein
HVX61_06155	COG2879	small protein
HVX61_06160	COG0371	Dehydrogenase
HVX61_06165	COG0436	Aminotransferase
HVX61_06170	COG1475	DNA binding
HVX61_06175	COG3969	phosphoadenosine phosphosulfate
HVX61_06180	COG0583	DNA-binding transcription factor activity
HVX61_06185	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HVX61_06190	COG0450	alkyl hydroperoxide reductase
HVX61_06195	COG3634	alkyl hydroperoxide reductase activity
HVX61_06200	COG0589	response to stress
HVX61_06210	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HVX61_06215	COG3719	Belongs to the RNase T2 family
HVX61_06220	COG0471	metal ion transport
HVX61_06235	COG3051	citrate lyase alpha subunit
HVX61_06240	COG2301	Belongs to the HpcH HpaI aldolase family
HVX61_06250	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
HVX61_06255	COG3290	protein histidine kinase activity
HVX61_06260	COG4565	transcriptional regulatory protein
HVX61_06265	COG3069	C4-dicarboxylate transmembrane transporter activity
HVX61_06285	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HVX61_06290	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HVX61_06300	COG0583	DNA-binding transcription factor activity
HVX61_06315	COG1686	Belongs to the peptidase S11 family
HVX61_06320	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HVX61_06325	COG0772	Belongs to the SEDS family
HVX61_06330	COG0768	penicillin binding
HVX61_06340	COG0799	negative regulation of ribosome biogenesis
HVX61_06345	COG0406	alpha-ribazole phosphatase activity
HVX61_06355	COG1466	dna polymerase III delta subunit
HVX61_06370	COG2888	peptidyl-tyrosine sulfation
HVX61_06375	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
HVX61_06385	COG2214	Heat shock protein DnaJ domain protein
HVX61_06390	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
HVX61_06405	COG0443	Heat shock 70 kDa protein
HVX61_06415	COG1126	abc transporter atp-binding protein
HVX61_06420	COG0765	amino acid transport
HVX61_06425	COG0765	amino acid transport
HVX61_06430	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HVX61_06435	COG0815	Transfers the fatty acyl group on membrane lipoproteins
HVX61_06440	COG4535	Mg2 and Co2 transporter CorC
HVX61_06450	COG1702	phosphate starvation-inducible protein PhoH
HVX61_06460	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HVX61_06500	COG0367	asparagine synthase
HVX61_06505	COG0647	UMP catabolic process
HVX61_06510	COG1846	Transcriptional regulator
HVX61_06510	COG1940	carbohydrate kinase activity
HVX61_06515	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HVX61_06525	COG2190	(PTS) system
HVX61_06525	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HVX61_06525	COG1263	PTS System
HVX61_06545	COG0735	belongs to the Fur family
HVX61_06555	COG0716	FMN binding
HVX61_06565	COG0596	Alpha beta hydrolase
HVX61_06570	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
HVX61_06575	COG0033	Phosphoglucomutase
HVX61_06580	COG0745	RESPONSE REGULATOR receiver
HVX61_06585	COG2205	protein histidine kinase activity
HVX61_06615	COG3272	Protein of unknown function (DUF1722)
HVX61_06620	COG0415	Belongs to the DNA photolyase family
HVX61_06630	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HVX61_06635	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
HVX61_06640	COG1984	allophanate hydrolase subunit 2
HVX61_06650	COG0266	class I DNA-(apurinic or apyrimidinic site) endonuclease activity
HVX61_06655	COG3180	Ammonia monooxygenase
HVX61_06660	COG3539	Fimbrial protein
HVX61_06665	COG3121	Chaperone
HVX61_06670	COG3188	usher protein
HVX61_06675	COG3539	Fimbrial protein
HVX61_06680	COG0372	Belongs to the citrate synthase family
HVX61_06690	COG2009	succinate dehydrogenase
HVX61_06695	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
HVX61_06700	COG1053	succinate dehydrogenase
HVX61_06705	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HVX61_06710	COG0567	Dehydrogenase, E1 component
HVX61_06715	COG0508	dehydrogenase complex catalyzes the overall conversion of
HVX61_06725	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HVX61_06730	COG0583	DNA-binding transcription factor activity
HVX61_06735	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
HVX61_06740	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
HVX61_06740	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HVX61_06745	COG1301	dicarboxylic acid transport
HVX61_06760	COG3799	methylaspartate ammonia-lyase activity
HVX61_06765	COG4865	methylaspartate mutase activity
HVX61_06775	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HVX61_06790	COG1271	oxidase subunit
HVX61_06795	COG1294	oxidase, subunit
HVX61_06800	COG4890	Cyd operon protein YbgT
HVX61_06805	COG3790	cyd operon protein YbgE
HVX61_06810	COG0824	Thioesterase
HVX61_06815	COG0811	peptide transport
HVX61_06820	COG0848	biopolymer transport protein
HVX61_06825	COG3064	Membrane
HVX61_06835	COG2885	chlorophyll binding
HVX61_06840	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
HVX61_06890	COG3201	nicotinamide mononucleotide transporter
HVX61_06895	COG1230	cation diffusion facilitator family transporter
HVX61_06905	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HVX61_06915	COG2017	converts alpha-aldose to the beta-anomer
HVX61_06925	COG1085	galactose-1-phosphate uridylyltransferase
HVX61_06930	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HVX61_06935	COG1119	ATPase activity
HVX61_06940	COG2005	Transcriptional regulator
HVX61_06940	COG3585	molybdate ion transport
HVX61_06950	COG0725	ABC transporter, periplasmic molybdate-binding protein
HVX61_06955	COG4149	molybdate abc transporter
HVX61_06965	COG0561	phosphatase activity
HVX61_06975	COG0583	DNA-binding transcription factor activity
HVX61_06980	COG2828	Protein conserved in bacteria
HVX61_06985	COG0471	metal ion transport
HVX61_06990	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HVX61_06995	COG4677	pectinesterase activity
HVX61_07000	COG0582	viral genome integration into host DNA
HVX61_07005	COG2801	Transposase and inactivated derivatives
HVX61_07020	COG0463	Glycosyl transferase, family 2
HVX61_07025	COG2246	polysaccharide biosynthetic process
HVX61_07035	COG1881	PFAM PEBP family protein
HVX61_07045	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HVX61_07060	COG2226	methyltransferase
HVX61_07065	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HVX61_07075	COG0391	Required for morphogenesis under gluconeogenic growth conditions
HVX61_07085	COG0521	Mo-molybdopterin cofactor biosynthetic process
HVX61_07095	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
HVX61_07100	COG0314	molybdopterin synthase activity
HVX61_07105	COG0670	Belongs to the BI1 family
HVX61_07110	COG0670	Belongs to the BI1 family
HVX61_07115	COG0392	lysyltransferase activity
HVX61_07120	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HVX61_07125	COG3568	Endonuclease Exonuclease Phosphatase
HVX61_07135	COG0842	Transport permease protein
HVX61_07140	COG0842	Transport permease protein
HVX61_07145	COG1131	(ABC) transporter
HVX61_07155	COG1309	transcriptional regulator
HVX61_07160	COG0513	Belongs to the DEAD box helicase family
HVX61_07175	COG1199	ATP-dependent helicase activity
HVX61_07180	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HVX61_07185	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
HVX61_07195	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HVX61_07205	COG4774	siderophore transport
HVX61_07220	COG0668	transmembrane transport
HVX61_07225	COG1126	abc transporter atp-binding protein
HVX61_07230	COG0765	amino acid transport
HVX61_07235	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HVX61_07245	COG5006	permease, DMT superfamily
HVX61_07255	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
HVX61_07260	COG2194	sulfuric ester hydrolase activity
HVX61_07270	COG4974	Belongs to the 'phage' integrase family
HVX61_07305	COG5002	protein histidine kinase activity
HVX61_07305	COG2176	DNA-directed DNA polymerase activity
HVX61_07330	COG4695	Portal protein
HVX61_07425	COG5301	cellulose 1,4-beta-cellobiosidase activity
HVX61_07430	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
HVX61_07460	COG1321	iron dependent repressor
HVX61_07465	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HVX61_07470	COG1376	ErfK ybiS ycfS ynhG family protein
HVX61_07475	COG0488	(ABC) transporter
HVX61_07485	COG0561	phosphatase activity
HVX61_07490	COG1882	Formate acetyltransferase
HVX61_07495	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HVX61_07500	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HVX61_07505	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HVX61_07510	COG0303	'Molybdopterin
HVX61_07515	COG1446	asparaginase
HVX61_07520	COG4172	Belongs to the ABC transporter superfamily
HVX61_07525	COG0747	negative chemotaxis
HVX61_07540	COG2200	EAL domain
HVX61_07545	COG2199	diguanylate cyclase activity
HVX61_07570	COG2133	pyrroloquinoline quinone binding
HVX61_07575	COG0625	glutathione transferase activity
HVX61_07580	COG1686	Belongs to the peptidase S11 family
HVX61_07585	COG1349	DNA-binding transcription factor activity
HVX61_07590	COG0671	phosphoesterase, PA-phosphatase related
HVX61_07595	COG2814	Major facilitator Superfamily
HVX61_07605	COG0561	phosphatase activity
HVX61_07610	COG0738	Major facilitator superfamily
HVX61_07615	COG3226	Transcriptional regulator
HVX61_07630	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HVX61_07640	COG0778	Nitroreductase
HVX61_07655	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HVX61_07660	COG3842	ATPase activity
HVX61_07665	COG1176	ABC-type spermidine putrescine transport system, permease component I
HVX61_07670	COG1177	transmembrane transport
HVX61_07700	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HVX61_07705	COG4160	amino acid transport
HVX61_07710	COG4215	(ABC) transporter
HVX61_07715	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HVX61_07720	COG1126	abc transporter atp-binding protein
HVX61_07740	COG3023	N-Acetylmuramoyl-L-alanine amidase
HVX61_07745	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HVX61_07750	COG0702	epimerase
HVX61_07755	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
HVX61_07760	COG0028	Belongs to the TPP enzyme family
HVX61_07765	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HVX61_07775	COG2431	L-lysine efflux transmembrane transporter activity
HVX61_07785	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HVX61_07790	COG3593	DNA synthesis involved in DNA repair
HVX61_07795	COG2990	Protein conserved in bacteria
HVX61_07800	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HVX61_07805	COG1136	(ABC) transporter
HVX61_07805	COG0577	efflux transmembrane transporter activity
HVX61_07810	COG1278	Cold shock
HVX61_07820	COG0542	response to heat
HVX61_07845	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
HVX61_07850	COG4988	ABC transporter
HVX61_07855	COG0492	ferredoxin-NADP+ reductase activity
HVX61_07860	COG1522	sequence-specific DNA binding
HVX61_07875	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HVX61_07885	COG0243	molybdopterin cofactor binding
HVX61_07890	COG0437	4 iron, 4 sulfur cluster binding
HVX61_07895	COG3302	dmso reductase anchor subunit
HVX61_07900	COG1335	isochorismatase
HVX61_07910	COG0531	amino acid
HVX61_07920	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HVX61_07925	COG1882	Formate acetyltransferase
HVX61_07930	COG2116	formate transmembrane transporter activity
HVX61_07935	COG1944	ATP diphosphatase activity
HVX61_07940	COG2323	membrane
HVX61_07955	COG0501	Belongs to the peptidase M48B family
HVX61_07965	COG0539	negative regulation of cytoplasmic translation
HVX61_07975	COG0658	competence protein
HVX61_07975	COG2333	competence protein COMEC
HVX61_07980	COG1132	(ABC) transporter
HVX61_07990	COG3214	Protein conserved in bacteria
HVX61_08005	COG3173	Aminoglycoside phosphotransferase
HVX61_08010	COG1434	Gram-negative-bacterium-type cell wall biogenesis
HVX61_08015	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HVX61_08025	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
HVX61_08035	COG2989	Protein conserved in bacteria
HVX61_08040	COG3108	Peptidase M15
HVX61_08045	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HVX61_08050	COG1448	Aminotransferase
HVX61_08055	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HVX61_08070	COG0308	aminopeptidase N
HVX61_08075	COG1116	anion transmembrane transporter activity
HVX61_08080	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HVX61_08090	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HVX61_08095	COG0431	NADPH-dependent FMN reductase
HVX61_08100	COG3539	Fimbrial protein
HVX61_08105	COG3121	Chaperone
HVX61_08110	COG3188	usher protein
HVX61_08115	COG3539	Fimbrial protein
HVX61_08120	COG3539	Fimbrial protein
HVX61_08125	COG3539	Fimbrial protein
HVX61_08130	COG3121	Chaperone
HVX61_08145	COG3217	Mosc domain protein beta barrel domain protein
HVX61_08145	COG0633	Ferredoxin
HVX61_08155	COG0488	(ABC) transporter
HVX61_08160	COG2995	paraquat-inducible protein a
HVX61_08165	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HVX61_08165	COG3008	intermembrane lipid transfer
HVX61_08170	COG3009	Protein conserved in bacteria
HVX61_08175	COG3130	regulation of translation
HVX61_08185	COG1067	ATP-dependent peptidase activity
HVX61_08205	COG3070	regulator of competence-specific genes
HVX61_08210	COG1289	transmembrane transporter activity
HVX61_08215	COG3304	Inner membrane component domain
HVX61_08220	COG0210	DNA helicase
HVX61_08235	COG1832	CoA-binding protein
HVX61_08250	COG1254	Belongs to the acylphosphatase family
HVX61_08255	COG2920	part of a sulfur-relay system
HVX61_08260	COG0670	Belongs to the BI1 family
HVX61_08270	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
HVX61_08275	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
HVX61_08280	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
HVX61_08285	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
HVX61_08290	COG1999	signal sequence binding
HVX61_08295	COG1773	rubredoxin
HVX61_08300	COG1271	oxidase subunit
HVX61_08305	COG1294	oxidase, subunit
HVX61_08320	COG0489	protein tyrosine kinase activity
HVX61_08320	COG3206	protein involved in exopolysaccharide biosynthesis
HVX61_08325	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HVX61_08330	COG1596	polysaccharide export
HVX61_08335	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HVX61_08355	COG1278	Cold shock
HVX61_08360	COG1278	Cold shock
HVX61_08380	COG0348	domain, Protein
HVX61_08385	COG2205	protein histidine kinase activity
HVX61_08385	COG2198	Histidine kinase
HVX61_08385	COG0784	Response regulator, receiver
HVX61_08390	COG1879	ABC-type sugar transport system periplasmic component
HVX61_08395	COG0745	RESPONSE REGULATOR receiver
HVX61_08400	COG3005	denitrification pathway
HVX61_08405	COG0243	molybdopterin cofactor binding
HVX61_08410	COG3381	protein complex oligomerization
HVX61_08445	COG3729	General stress protein
HVX61_08450	COG2233	PERMEase
HVX61_08485	COG1309	transcriptional regulator
HVX61_08490	COG0506	proline dehydrogenase activity
HVX61_08490	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HVX61_08490	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HVX61_08495	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HVX61_08510	COG2822	iron ion transport
HVX61_08520	COG1702	phosphate starvation-inducible protein PhoH
HVX61_08525	COG3658	cytochrome
HVX61_08530	COG1215	transferase activity, transferring glycosyl groups
HVX61_08535	COG1649	PFAM Uncharacterised BCR, COG1649
HVX61_08535	COG0726	polysaccharide deacetylase
HVX61_08540	COG0457	Tetratricopeptide repeat
HVX61_08545	COG3706	GGDEF domain
HVX61_08550	COG2200	EAL domain
HVX61_08560	COG3710	Transcriptional regulator
HVX61_08565	COG1028	Short-chain dehydrogenase reductase Sdr
HVX61_08570	COG3121	Chaperone
HVX61_08580	COG3188	usher protein
HVX61_08590	COG3539	Fimbrial protein
HVX61_08600	COG3210	domain, Protein
HVX61_08605	COG2831	hemolysin activation secretion protein
HVX61_08610	COG0736	holo-[acyl-carrier-protein] synthase activity
HVX61_08620	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HVX61_08630	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HVX61_08635	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HVX61_08700	COG3381	protein complex oligomerization
HVX61_08710	COG1462	curli production assembly transport component CsgG
HVX61_08725	COG2197	response regulator
HVX61_08750	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
HVX61_08755	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HVX61_08770	COG2943	transferase activity, transferring hexosyl groups
HVX61_08775	COG5645	(Lipo)protein
HVX61_08790	COG1560	Kdo2-lipid A biosynthetic process
HVX61_08800	COG2353	YceI-like domain
HVX61_08805	COG3038	cytochrome b561
HVX61_08840	COG2999	glutathione oxidoreductase activity
HVX61_08850	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HVX61_08860	COG0673	inositol 2-dehydrogenase activity
HVX61_08865	COG0728	peptidoglycan biosynthetic process
HVX61_08870	COG3418	PFAM FlgN family protein
HVX61_08875	COG2747	anti-sigma28 factor FlgM
HVX61_08880	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
HVX61_08885	COG1815	bacterial-type flagellum-dependent cell motility
HVX61_08890	COG1558	bacterial-type flagellum-dependent cell motility
HVX61_08895	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
HVX61_08900	COG1749	Flagellar hook protein flgE
HVX61_08905	COG4787	bacterial-type flagellum-dependent cell motility
HVX61_08910	COG4786	Flagellar basal body rod
HVX61_08925	COG3951	Flagellar rod assembly protein muramidase FlgJ
HVX61_08925	COG1705	Flagellar rod assembly protein muramidase FlgJ
HVX61_08930	COG1256	bacterial-type flagellum assembly
HVX61_08935	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HVX61_08940	COG1530	ribonuclease E activity
HVX61_08945	COG0564	pseudouridine synthase activity
HVX61_08950	COG0424	maF-like protein
HVX61_08955	COG1399	metal-binding, possibly nucleic acid-binding protein
HVX61_08975	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HVX61_08980	COG1028	Short-chain dehydrogenase reductase Sdr
HVX61_08990	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HVX61_08995	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HVX61_09000	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HVX61_09010	COG0470	DNA polymerase III
HVX61_09015	COG0084	hydrolase, TatD family'
HVX61_09020	COG1263	PTS System
HVX61_09020	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HVX61_09025	COG4773	Receptor
HVX61_09030	COG0537	adenosine 5'-monophosphoramidase activity
HVX61_09035	COG5633	Lipoprotein
HVX61_09040	COG3417	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)
HVX61_09045	COG0510	thiamine kinase activity
HVX61_09060	COG1252	NADH dehydrogenase
HVX61_09065	COG3134	Outer membrane lipoprotein
HVX61_09070	COG1309	transcriptional regulator
HVX61_09080	COG1388	LysM domain
HVX61_09080	COG1376	ErfK ybiS ycfS ynhG family protein
HVX61_09085	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HVX61_09090	COG4763	Acyl-transferase
HVX61_09095	COG4591	ABC-type transport system involved in lipoprotein release permease component
HVX61_09105	COG4591	ABC-type transport system involved in lipoprotein release permease component
HVX61_09115	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HVX61_09120	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HVX61_09125	COG1177	transmembrane transport
HVX61_09140	COG0582	viral genome integration into host DNA
HVX61_09150	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HVX61_09260	COG1403	HNH endonuclease
HVX61_09265	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
HVX61_09280	COG2207	Transcriptional regulator
HVX61_09305	COG5562	phage envelope protein
HVX61_09315	COG4220	transposase activity
HVX61_09525	COG5301	cellulose 1,4-beta-cellobiosidase activity
HVX61_09530	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
HVX61_09540	COG3842	ATPase activity
HVX61_09550	COG2850	peptidyl-arginine hydroxylation
HVX61_09555	COG2205	protein histidine kinase activity
HVX61_09565	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HVX61_09585	COG1187	pseudouridine synthase activity
HVX61_09590	COG0538	isocitrate dehydrogenase activity
HVX61_09615	COG5562	phage envelope protein
HVX61_09620	COG0789	Transcriptional regulator
HVX61_09625	COG2200	EAL domain
HVX61_09650	COG2200	EAL domain
HVX61_09700	COG2894	cell division
HVX61_09725	COG0179	Fumarylacetoacetate (FAA) hydrolase
HVX61_09740	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HVX61_09745	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HVX61_09750	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
HVX61_09775	COG2719	SpoVR family
HVX61_09785	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HVX61_09805	COG1619	proteins homologs of microcin C7 resistance protein MccF
HVX61_09815	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
HVX61_09830	COG0157	Belongs to the NadC ModD family
HVX61_09835	COG0500	methyltransferase
HVX61_09840	COG1120	ATPase activity
HVX61_09860	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
HVX61_09860	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HVX61_09860	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HVX61_09865	COG1461	Dihydroxyacetone kinase
HVX61_09870	COG2376	Dihydroxyacetone kinase
HVX61_09875	COG3284	Transcriptional regulator
HVX61_09880	COG3468	outer membrane autotransporter barrel domain protein
HVX61_09885	COG0012	GTP binding
HVX61_09900	COG0659	secondary active sulfate transmembrane transporter activity
HVX61_09905	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HVX61_09930	COG2890	protein-(glutamine-N5) methyltransferase activity
HVX61_09935	COG3094	Invasion gene expression up-regulator, SirB
HVX61_09940	COG2912	Transglutaminase-like superfamily
HVX61_09960	COG0387	Pfam Sodium calcium exchanger
HVX61_09965	COG4572	Cation transport regulator
HVX61_09970	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
HVX61_09975	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
HVX61_09980	COG4932	domain protein
HVX61_09985	COG2197	response regulator
HVX61_09990	COG3850	Histidine kinase
HVX61_09995	COG2223	nitrite transmembrane transporter activity
HVX61_10000	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
HVX61_10005	COG1140	nitrate reductase beta subunit
HVX61_10010	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
HVX61_10015	COG2181	nitrate reductase activity
HVX61_10035	COG0788	formyltetrahydrofolate deformylase activity
HVX61_10045	COG1752	Esterase of the alpha-beta hydrolase superfamily
HVX61_10050	COG0745	RESPONSE REGULATOR receiver
HVX61_10055	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HVX61_10070	COG1435	thymidine kinase activity
HVX61_10075	COG1012	belongs to the aldehyde dehydrogenase family
HVX61_10075	COG1454	alcohol dehydrogenase
HVX61_10080	COG2095	MarC family integral membrane protein
HVX61_10090	COG4166	transmembrane transport
HVX61_10095	COG0601	transmembrane transport
HVX61_10100	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HVX61_10105	COG0444	Belongs to the ABC transporter superfamily
HVX61_10110	COG4608	Belongs to the ABC transporter superfamily
HVX61_10130	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HVX61_10135	COG2350	Protein conserved in bacteria
HVX61_10140	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
HVX61_10145	COG1607	acyl-coa hydrolase
HVX61_10165	COG3047	cAMP biosynthetic process
HVX61_10170	COG3685	Protein conserved in bacteria
HVX61_10175	COG3685	Protein conserved in bacteria
HVX61_10180	COG3729	General stress protein
HVX61_10185	COG0159	tryptophan synthase activity
HVX61_10195	COG0135	phosphoribosylanthranilate isomerase activity
HVX61_10195	COG0134	indole-3-glycerol-phosphate synthase activity
HVX61_10200	COG0512	Glutamine amidotransferase of anthranilate synthase
HVX61_10200	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HVX61_10205	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HVX61_10215	COG0613	PHP domain protein
HVX61_10220	COG0009	L-threonylcarbamoyladenylate synthase
HVX61_10225	COG4907	membrane protein (DUF2207)
HVX61_10230	COG1187	pseudouridine synthase activity
HVX61_10235	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
HVX61_10240	COG1028	Short-chain dehydrogenase reductase Sdr
HVX61_10245	COG0616	signal peptide processing
HVX61_10260	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HVX61_10265	COG0583	DNA-binding transcription factor activity
HVX61_10285	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HVX61_10295	COG0671	phosphoesterase, PA-phosphatase related
HVX61_10300	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
HVX61_10305	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
HVX61_10315	COG0023	Translation Initiation Factor
HVX61_10325	COG1349	DNA-binding transcription factor activity
HVX61_10335	COG5001	Diguanylate cyclase
HVX61_10355	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HVX61_10355	COG4950	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HVX61_10360	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HVX61_10370	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HVX61_10375	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HVX61_10385	COG2814	Major facilitator Superfamily
HVX61_10390	COG4172	Belongs to the ABC transporter superfamily
HVX61_10395	COG4172	Belongs to the ABC transporter superfamily
HVX61_10400	COG4171	peptide transport system, permease
HVX61_10405	COG4168	peptide transport system, permease
HVX61_10410	COG4166	transmembrane transport
HVX61_10420	COG0531	amino acid
HVX61_10430	COG0174	glutamine synthetase
HVX61_10435	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
HVX61_10440	COG1917	Cupin 2, conserved barrel domain protein
HVX61_10440	COG1396	sequence-specific DNA binding
HVX61_10445	COG1012	belongs to the aldehyde dehydrogenase family
HVX61_10450	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HVX61_10455	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HVX61_10460	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
HVX61_10465	COG1842	Phage shock protein A
HVX61_10475	COG1983	PspC domain protein
HVX61_10485	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HVX61_10490	COG3106	COG3106 Predicted ATPase
HVX61_10500	COG3283	Transcriptional regulator of aromatic amino acids metabolism
HVX61_10505	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
HVX61_10510	COG4948	Mandelate Racemase Muconate Lactonizing
HVX61_10515	COG2866	Carboxypeptidase
HVX61_10525	COG0702	epimerase
HVX61_10535	COG1073	alpha beta
HVX61_10540	COG0583	DNA-binding transcription factor activity
HVX61_10545	COG4166	transmembrane transport
HVX61_10550	COG0668	transmembrane transport
HVX61_10555	COG3182	Iron-regulated membrane protein
HVX61_10560	COG0589	response to stress
HVX61_10565	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HVX61_10570	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HVX61_10580	COG2207	Transcriptional regulator
HVX61_10595	COG2840	Smr protein MutS2
HVX61_10600	COG3706	GGDEF domain
HVX61_10610	COG0513	Belongs to the DEAD box helicase family
HVX61_10620	COG0589	response to stress
HVX61_10625	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HVX61_10635	COG1013	pyruvate-flavodoxin oxidoreductase activity
HVX61_10635	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HVX61_10635	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HVX61_10635	COG0674	pyruvate-flavodoxin oxidoreductase activity
HVX61_10640	COG3042	response to heat
HVX61_10645	COG3187	Heat shock protein
HVX61_10650	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HVX61_10655	COG2911	Protein conserved in bacteria
HVX61_10665	COG3784	Protein of unknown function (DUF1318)
HVX61_10670	COG2207	Transcriptional regulator
HVX61_10675	COG1012	belongs to the aldehyde dehydrogenase family
HVX61_10680	COG3733	amine oxidase
HVX61_10685	COG1012	belongs to the aldehyde dehydrogenase family
HVX61_10685	COG2030	dehydratase
HVX61_10690	COG3396	Phenylacetate-CoA oxygenase
HVX61_10695	COG3460	Phenylacetate-CoA oxygenase
HVX61_10700	COG3396	Phenylacetate-CoA oxygenase
HVX61_10705	COG2151	metal-sulfur cluster biosynthetic enzyme
HVX61_10710	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HVX61_10715	COG1024	Enoyl-CoA hydratase
HVX61_10720	COG1024	Enoyl-CoA hydratase
HVX61_10725	COG1250	3-hydroxyacyl-CoA dehydrogenase
HVX61_10730	COG2050	protein possibly involved in aromatic compounds catabolism
HVX61_10735	COG0183	Belongs to the thiolase family
HVX61_10740	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
HVX61_10745	COG3327	negative regulation of DNA-templated transcription, initiation
HVX61_10750	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HVX61_10755	COG0667	Aldo Keto reductase
HVX61_10765	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HVX61_10770	COG4589	Belongs to the CDS family
HVX61_10775	COG2267	carboxylic ester hydrolase activity
HVX61_10780	COG0671	phosphoesterase, PA-phosphatase related
HVX61_10780	COG2453	phosphatase
HVX61_10790	COG1643	Atp-dependent helicase
HVX61_10795	COG1434	Gram-negative-bacterium-type cell wall biogenesis
HVX61_10800	COG1012	belongs to the aldehyde dehydrogenase family
HVX61_10805	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HVX61_10810	COG3038	cytochrome b561
HVX61_10825	COG0840	transmembrane signaling receptor activity
HVX61_10830	COG0583	DNA-binding transcription factor activity
HVX61_10835	COG5383	Protein conserved in bacteria
HVX61_10845	COG2841	Protein conserved in bacteria
HVX61_10850	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HVX61_10855	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HVX61_10860	COG1275	C4-dicarboxylate transporter malic acid transport protein
HVX61_10865	COG0500	methyltransferase
HVX61_10880	COG0675	Transposase, IS605 OrfB family
HVX61_10885	COG3135	benzoate transporter
HVX61_10890	COG1396	sequence-specific DNA binding
HVX61_10895	COG0826	peptidase U32
HVX61_10905	COG1724	mRNA binding
HVX61_10910	COG1598	PFAM Uncharacterised protein family UPF0150
HVX61_10915	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HVX61_10920	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HVX61_10925	COG3842	ATPase activity
HVX61_10930	COG1176	ABC-type spermidine putrescine transport system, permease component I
HVX61_10935	COG1177	transmembrane transport
HVX61_10960	COG3238	Protein conserved in bacteria
HVX61_10965	COG1247	-acetyltransferase
HVX61_10970	COG2130	NADP-dependent
HVX61_10975	COG1802	Transcriptional regulator
HVX61_10980	COG4772	TonB-dependent receptor
HVX61_10985	COG3391	amine dehydrogenase activity
HVX61_10990	COG1113	amino acid transport
HVX61_10995	COG0625	glutathione transferase activity
HVX61_11045	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HVX61_11050	COG2162	N-hydroxyarylamine O-acetyltransferase activity
HVX61_11055	COG0384	phenazine biosynthesis protein PhzF
HVX61_11060	COG2181	nitrate reductase activity
HVX61_11065	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
HVX61_11070	COG1140	nitrate reductase beta subunit
HVX61_11075	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
HVX61_11080	COG2223	nitrite transmembrane transporter activity
HVX61_11085	COG4886	Leucine-rich repeat (LRR) protein
HVX61_11090	COG4886	Leucine-rich repeat (LRR) protein
HVX61_11100	COG0697	spore germination
HVX61_11110	COG0437	4 iron, 4 sulfur cluster binding
HVX61_11115	COG2864	formate dehydrogenase
HVX61_11120	COG3093	addiction module antidote protein HigA
HVX61_11125	COG1064	alcohol dehydrogenase
HVX61_11145	COG1764	response to oxidative stress
HVX61_11150	COG4608	Belongs to the ABC transporter superfamily
HVX61_11155	COG0444	Belongs to the ABC transporter superfamily
HVX61_11160	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HVX61_11165	COG0601	transmembrane transport
HVX61_11170	COG0747	negative chemotaxis
HVX61_11175	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
HVX61_11180	COG2200	EAL domain
HVX61_11180	COG2202	Pas domain
HVX61_11180	COG2199	diguanylate cyclase activity
HVX61_11185	COG3706	GGDEF domain
HVX61_11200	COG0531	amino acid
HVX61_11205	COG0076	glutamate decarboxylase activity
HVX61_11210	COG0612	Peptidase, M16
HVX61_11215	COG4771	TonB-dependent receptor
HVX61_11220	COG4178	(ABC) transporter
HVX61_11230	COG0641	radical SAM
HVX61_11235	COG3119	arylsulfatase activity
HVX61_11250	COG0243	molybdopterin cofactor binding
HVX61_11255	COG3539	Fimbrial protein
HVX61_11260	COG3539	Fimbrial protein
HVX61_11265	COG3539	Fimbrial protein
HVX61_11270	COG3188	usher protein
HVX61_11280	COG3539	Fimbrial protein
HVX61_11290	COG3550	peptidyl-serine autophosphorylation
HVX61_11295	COG1396	sequence-specific DNA binding
HVX61_11310	COG1070	Carbohydrate kinase
HVX61_11355	COG0675	Transposase, IS605 OrfB family
HVX61_11365	COG3781	membrane
HVX61_11375	COG2199	diguanylate cyclase activity
HVX61_11385	COG2066	Belongs to the glutaminase family
HVX61_11390	COG1012	belongs to the aldehyde dehydrogenase family
HVX61_11395	COG0583	DNA-binding transcription factor activity
HVX61_11415	COG1846	Transcriptional regulator
HVX61_11420	COG4977	sequence-specific DNA binding
HVX61_11430	COG0697	spore germination
HVX61_11435	COG2814	Major facilitator Superfamily
HVX61_11445	COG3706	GGDEF domain
HVX61_11450	COG3111	PFAM Bacterial OB fold (BOF) protein
HVX61_11455	COG1546	Belongs to the CinA family
HVX61_11460	COG0339	signal peptide processing
HVX61_11465	COG4221	oxidoreductase activity
HVX61_11470	COG1802	Transcriptional regulator
HVX61_11480	COG0246	Mannitol dehydrogenase
HVX61_11500	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HVX61_11505	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
HVX61_11510	COG5301	cellulose 1,4-beta-cellobiosidase activity
HVX61_11585	COG0740	serine-type endopeptidase activity
HVX61_11615	COG5562	phage envelope protein
HVX61_11640	COG1278	Cold shock
HVX61_11650	COG3772	lysozyme
HVX61_11665	COG1278	Cold shock
HVX61_11670	COG1278	Cold shock
HVX61_11680	COG0484	heat shock protein binding
HVX61_11685	COG1403	HNH endonuclease
HVX61_11705	COG2026	Addiction module toxin, RelE StbE family
HVX61_11710	COG3077	Addiction module antitoxin, RelB DinJ family
HVX61_11725	COG2801	Transposase and inactivated derivatives
HVX61_11745	COG1846	Transcriptional regulator
HVX61_11760	COG1396	sequence-specific DNA binding
HVX61_11785	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HVX61_11795	COG0582	viral genome integration into host DNA
HVX61_11805	COG1063	alcohol dehydrogenase
HVX61_11810	COG4948	Mandelate Racemase Muconate Lactonizing
HVX61_11825	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HVX61_11840	COG0243	molybdopterin cofactor binding
HVX61_11845	COG0243	molybdopterin cofactor binding
HVX61_11850	COG0437	4 iron, 4 sulfur cluster binding
HVX61_11855	COG3302	dmso reductase anchor subunit
HVX61_11860	COG3381	protein complex oligomerization
HVX61_11870	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HVX61_11875	COG1940	carbohydrate kinase activity
HVX61_11880	COG0583	DNA-binding transcription factor activity
HVX61_11885	COG2814	Major facilitator Superfamily
HVX61_11900	COG3591	Belongs to the peptidase S1B family
HVX61_11915	COG0628	permease
HVX61_11920	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
HVX61_11925	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
HVX61_11935	COG0531	amino acid
HVX61_11945	COG3136	membrane protein required for alginate biosynthesis
HVX61_11950	COG0745	RESPONSE REGULATOR receiver
HVX61_11955	COG2205	protein histidine kinase activity
HVX61_11965	COG0114	fumarate hydratase activity
HVX61_11970	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
HVX61_11970	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HVX61_11980	COG5339	Protein conserved in bacteria
HVX61_11995	COG3250	beta-galactosidase activity
HVX61_12000	COG1309	transcriptional regulator
HVX61_12005	COG1028	Short-chain dehydrogenase reductase Sdr
HVX61_12010	COG1609	Transcriptional regulator
HVX61_12015	COG1263	PTS System
HVX61_12015	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HVX61_12020	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HVX61_12030	COG0673	inositol 2-dehydrogenase activity
HVX61_12070	COG4659	FMN binding
HVX61_12080	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HVX61_12085	COG3104	oligopeptide transport
HVX61_12090	COG0625	glutathione transferase activity
HVX61_12095	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
HVX61_12110	COG3895	Periplasmic Protein
HVX61_12120	COG3133	Outer membrane lipoprotein
HVX61_12135	COG1566	PFAM secretion protein HlyD family protein
HVX61_12140	COG1289	transmembrane transporter activity
HVX61_12145	COG2032	superoxide dismutase activity
HVX61_12150	COG4989	oxidoreductase activity
HVX61_12155	COG3313	Fe-S protein
HVX61_12160	COG1309	transcriptional regulator
HVX61_12165	COG1902	pentaerythritol trinitrate reductase activity
HVX61_12170	COG0346	lactoylglutathione lyase activity
HVX61_12180	COG1201	RNA secondary structure unwinding
HVX61_12185	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
HVX61_12190	COG0791	NLP P60 protein
HVX61_12195	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HVX61_12200	COG2814	Major facilitator Superfamily
HVX61_12215	COG0583	DNA-binding transcription factor activity
HVX61_12220	COG2814	Major facilitator Superfamily
HVX61_12225	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HVX61_12230	COG0307	riboflavin synthase, alpha
HVX61_12240	COG3468	outer membrane autotransporter barrel domain protein
HVX61_12260	COG4529	Protein conserved in bacteria
HVX61_12270	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
HVX61_12275	COG0437	4 iron, 4 sulfur cluster binding
HVX61_12285	COG2414	aldehyde ferredoxin oxidoreductase
HVX61_12290	COG0437	4 iron, 4 sulfur cluster binding
HVX61_12300	COG0469	pyruvate kinase activity
HVX61_12305	COG4238	major outer membrane lipoprotein
HVX61_12310	COG1376	ErfK ybiS ycfS ynhG family protein
HVX61_12325	COG0719	Fe-S assembly protein
HVX61_12330	COG0396	ATPase activity
HVX61_12335	COG0719	Fe-S assembly protein
HVX61_12340	COG0316	Belongs to the HesB IscA family
HVX61_12350	COG2050	protein possibly involved in aromatic compounds catabolism
HVX61_12355	COG0247	lactate metabolic process
HVX61_12355	COG0277	FAD linked oxidase domain protein
HVX61_12360	COG0628	permease
HVX61_12375	COG0738	Major facilitator superfamily
HVX61_12380	COG2271	Major facilitator Superfamily
HVX61_12395	COG4670	ketone body catabolic process
HVX61_12400	COG1960	acyl-CoA dehydrogenase activity
HVX61_12405	COG1917	Cupin 2, conserved barrel domain protein
HVX61_12405	COG2207	Transcriptional regulator
HVX61_12410	COG2086	electron transfer activity
HVX61_12415	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
HVX61_12420	COG0644	oxidoreductase
HVX61_12425	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
HVX61_12430	COG0318	PFAM AMP-dependent synthetase and ligase
HVX61_12435	COG0574	Belongs to the PEP-utilizing enzyme family
HVX61_12435	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HVX61_12445	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HVX61_12450	COG4256	Hemin uptake protein
HVX61_12460	COG2200	EAL domain
HVX61_12465	COG0791	NLP P60 protein
HVX61_12475	COG0386	Belongs to the glutathione peroxidase family
HVX61_12490	COG0072	phenylalanine-tRNA ligase activity
HVX61_12490	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HVX61_12535	COG3137	Salt-induced outer membrane protein
HVX61_12540	COG1105	Belongs to the carbohydrate kinase PfkB family
HVX61_12550	COG3001	Fructosamine kinase
HVX61_12560	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HVX61_12565	COG1988	membrane-bound metal-dependent
HVX61_12585	COG0753	catalase activity
HVX61_12595	COG1486	melibiose metabolic process
HVX61_12600	COG2169	Transcriptional regulator
HVX61_12600	COG1917	Cupin 2, conserved barrel domain protein
HVX61_12605	COG1447	Phosphotransferase system cellobiose-specific component IIA
HVX61_12610	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HVX61_12615	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HVX61_12620	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HVX61_12630	COG0322	excinuclease ABC activity
HVX61_12640	COG3678	ATP-independent chaperone mediated protein folding
HVX61_12670	COG0708	Exodeoxyribonuclease III
HVX61_12675	COG0398	Pfam SNARE associated Golgi protein
HVX61_12685	COG0398	Pfam SNARE associated Golgi protein
HVX61_12690	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HVX61_12695	COG4134	Bacterial extracellular solute-binding protein
HVX61_12700	COG4135	transport system, permease component
HVX61_12705	COG4136	ATPase activity
HVX61_12710	COG2897	thiosulfate sulfurtransferase activity
HVX61_12715	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HVX61_12720	COG0494	nUDIX hydrolase
HVX61_12730	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HVX61_12740	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HVX61_12745	COG0709	Synthesizes selenophosphate from selenide and ATP
HVX61_12750	COG0778	Nitroreductase
HVX61_12755	COG0616	signal peptide processing
HVX61_12760	COG0252	asparaginase activity
HVX61_12765	COG1335	isochorismatase
HVX61_12770	COG2814	Major facilitator Superfamily
HVX61_12775	COG1349	DNA-binding transcription factor activity
HVX61_12780	COG0667	Aldo Keto reductase
HVX61_12785	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HVX61_12790	COG0191	fructose-bisphosphate aldolase activity
HVX61_12795	COG1063	alcohol dehydrogenase
HVX61_12800	COG2271	Major facilitator Superfamily
HVX61_12805	COG1063	alcohol dehydrogenase
HVX61_12810	COG3139	Protein of unknown function (DUF1315)
HVX61_12820	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HVX61_12825	COG0676	glucose-6-phosphate 1-epimerase activity
HVX61_12830	COG0656	L-ascorbic acid biosynthetic process
HVX61_12835	COG3713	MltA-interacting MipA family protein
HVX61_12840	COG2766	serine protein kinase
HVX61_12850	COG2199	diguanylate cyclase activity
HVX61_12855	COG2199	diguanylate cyclase activity
HVX61_12860	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HVX61_12875	COG2207	Transcriptional regulator
HVX61_12880	COG2807	transmembrane transport
HVX61_12885	COG3189	MarR family transcriptional regulator
HVX61_12890	COG3042	response to heat
HVX61_12895	COG2199	diguanylate cyclase activity
HVX61_12895	COG2203	Gaf domain
HVX61_12910	COG2261	transglycosylase associated protein
HVX61_12920	COG3615	Tellurite resistance protein tehB
HVX61_12930	COG0583	DNA-binding transcription factor activity
HVX61_12935	COG0473	3-isopropylmalate dehydrogenase activity
HVX61_12940	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HVX61_12945	COG4638	Rieske (2fe-2S)
HVX61_12950	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HVX61_12955	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
HVX61_12960	COG0318	PFAM AMP-dependent synthetase and ligase
HVX61_12965	COG3065	identical protein binding
HVX61_12970	COG1214	PFAM Peptidase M22, glycoprotease
HVX61_12975	COG1199	ATP-dependent helicase activity
HVX61_12980	COG0251	oxidation-reduction process
HVX61_12995	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HVX61_13005	COG1760	l-serine dehydratase
HVX61_13010	COG2200	EAL domain
HVX61_13015	COG1253	flavin adenine dinucleotide binding
HVX61_13020	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HVX61_13020	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HVX61_13025	COG3715	PTS system
HVX61_13030	COG3716	PTS system mannose fructose sorbose family IID component
HVX61_13045	COG2226	methyltransferase
HVX61_13080	COG1414	Transcriptional regulator
HVX61_13085	COG2814	Major facilitator Superfamily
HVX61_13100	COG0793	Belongs to the peptidase S41A family
HVX61_13110	COG1956	GAF domain-containing protein
HVX61_13115	COG2995	paraquat-inducible protein a
HVX61_13120	COG3008	intermembrane lipid transfer
HVX61_13140	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HVX61_13150	COG1276	copper resistance
HVX61_13155	COG2372	response to copper ion
HVX61_13165	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HVX61_13170	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HVX61_13175	COG1770	oligopeptidase
HVX61_13180	COG2979	Protein of unknown function (DUF533)
HVX61_13190	COG3141	response to X-ray
HVX61_13200	COG0800	Aldolase
HVX61_13205	COG0129	dihydroxy-acid dehydratase activity
HVX61_13210	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HVX61_13215	COG1737	Transcriptional regulator
HVX61_13220	COG0469	pyruvate kinase activity
HVX61_13225	COG1560	Kdo2-lipid A biosynthetic process
HVX61_13230	COG0739	heme binding
HVX61_13235	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
HVX61_13245	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HVX61_13275	COG0217	transcriptional regulatory protein
HVX61_13280	COG0494	nUDIX hydrolase
HVX61_13290	COG1335	isochorismatase
HVX61_13295	COG1801	Protein of unknown function DUF72
HVX61_13300	COG3788	relative of glutathione S-transferase, MAPEG superfamily
HVX61_13315	COG0243	molybdopterin cofactor binding
HVX61_13320	COG3005	denitrification pathway
HVX61_13330	COG3102	Protein conserved in bacteria
HVX61_13340	COG3755	Protein conserved in bacteria
HVX61_13350	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HVX61_13355	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HVX61_13365	COG0745	RESPONSE REGULATOR receiver
HVX61_13375	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
HVX61_13380	COG0840	transmembrane signaling receptor activity
HVX61_13385	COG0840	transmembrane signaling receptor activity
HVX61_13390	COG0835	chemotaxis
HVX61_13395	COG0643	Histidine kinase
HVX61_13395	COG2198	Histidine kinase
HVX61_13400	COG1360	Flagellar Motor Protein
HVX61_13405	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
HVX61_13420	COG0589	response to stress
HVX61_13430	COG1877	trehalose-phosphatase activity
HVX61_13435	COG1172	Belongs to the binding-protein-dependent transport system permease family
HVX61_13440	COG1129	ABC transporter
HVX61_13445	COG1879	ABC-type sugar transport system periplasmic component
HVX61_13450	COG1528	Iron-storage protein
HVX61_13470	COG1528	Iron-storage protein
HVX61_13480	COG0814	amino acid
HVX61_13485	COG3318	Belongs to the UPF0149 family
HVX61_13485	COG3012	SEC-C Motif Domain Protein
HVX61_13515	COG2197	response regulator
HVX61_13530	COG2197	response regulator
HVX61_13560	COG1191	sigma factor activity
HVX61_13565	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HVX61_13570	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
HVX61_13575	COG1516	flagellar protein fliS
HVX61_13585	COG0366	Alpha amylase catalytic
HVX61_13595	COG2391	methyltransferase activity
HVX61_13600	COG0425	Belongs to the sulfur carrier protein TusA family
HVX61_13605	COG2135	peptidase activity
HVX61_13610	COG0454	-acetyltransferase
HVX61_13625	COG1766	The M ring may be actively involved in energy transduction
HVX61_13630	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HVX61_13635	COG1317	bacterial-type flagellum organization
HVX61_13640	COG1157	protein secretion by the type III secretion system
HVX61_13645	COG2882	bacterial-type flagellum organization
HVX61_13650	COG3144	bacterial-type flagellum assembly
HVX61_13655	COG1580	Controls the rotational direction of flagella during chemotaxis
HVX61_13660	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HVX61_13665	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HVX61_13670	COG3190	flagellar
HVX61_13675	COG1338	Plays a role in the flagellum-specific transport system
HVX61_13680	COG1987	bacterial-type flagellum assembly
HVX61_13685	COG1684	flagellar biosynthetic protein fliR
HVX61_13690	COG2197	response regulator
HVX61_13710	COG3706	GGDEF domain
HVX61_13715	COG5475	Uncharacterized small protein (DUF2158)
HVX61_13720	COG2354	Protein conserved in bacteria
HVX61_13725	COG0697	spore germination
HVX61_13730	COG3727	T/G mismatch-specific endonuclease activity
HVX61_13735	COG0270	DNA (cytosine-5-)-methyltransferase activity
HVX61_13740	COG1418	mRNA catabolic process
HVX61_13750	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HVX61_13760	COG2205	protein histidine kinase activity
HVX61_13765	COG0745	RESPONSE REGULATOR receiver
HVX61_13770	COG2351	hydroxyisourate hydrolase activity
HVX61_13785	COG3443	Belongs to the bacterial solute-binding protein 9 family
HVX61_13790	COG3038	cytochrome b561
HVX61_13810	COG4932	domain protein
HVX61_13810	COG2373	Large extracellular alpha-helical protein
HVX61_13810	COG1388	LysM domain
HVX61_13820	COG0477	Major facilitator Superfamily
HVX61_13825	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HVX61_13830	COG0217	transcriptional regulatory protein
HVX61_13840	COG0534	Mate efflux family protein
HVX61_13850	COG0583	DNA-binding transcription factor activity
HVX61_13855	COG0583	DNA-binding transcription factor activity
HVX61_13865	COG1376	ErfK ybiS ycfS ynhG family protein
HVX61_13880	COG2087	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate
HVX61_13900	COG1289	transmembrane transporter activity
HVX61_13915	COG2925	Exonuclease
HVX61_13920	COG0425	Belongs to the sulfur carrier protein TusA family
HVX61_13925	COG2391	methyltransferase activity
HVX61_13930	COG0531	amino acid
HVX61_13940	COG0583	DNA-binding transcription factor activity
HVX61_13945	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HVX61_13950	COG4115	mRNA cleavage
HVX61_13955	COG2161	toxin-antitoxin pair type II binding
HVX61_13985	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HVX61_14000	COG0140	phosphoribosyl-ATP diphosphatase activity
HVX61_14000	COG0139	Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP
HVX61_14005	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
HVX61_14015	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
HVX61_14035	COG1216	Glycosyl transferase, family 2
HVX61_14035	COG0463	Glycosyl transferase, family 2
HVX61_14055	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HVX61_14060	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HVX61_14070	COG0438	transferase activity, transferring glycosyl groups
HVX61_14075	COG2327	Polysaccharide pyruvyl transferase
HVX61_14080	COG2244	polysaccharide biosynthetic process
HVX61_14085	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HVX61_14090	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HVX61_14095	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
HVX61_14095	COG0662	Cupin 2, conserved barrel domain protein
HVX61_14100	COG0297	glycogen (starch) synthase activity
HVX61_14105	COG1051	belongs to the nudix hydrolase family
HVX61_14110	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HVX61_14115	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
HVX61_14120	COG0110	maltose O-acetyltransferase activity
HVX61_14125	COG1216	Glycosyl transferase, family 2
HVX61_14135	COG0438	transferase activity, transferring glycosyl groups
HVX61_14140	COG1045	serine acetyltransferase
HVX61_14145	COG0463	Glycosyl transferase, family 2
HVX61_14150	COG3206	protein involved in exopolysaccharide biosynthesis
HVX61_14150	COG0489	protein tyrosine kinase activity
HVX61_14155	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HVX61_14160	COG1596	polysaccharide export
HVX61_14170	COG1253	flavin adenine dinucleotide binding
HVX61_14180	COG2982	Protein involved in outer membrane biogenesis
HVX61_14190	COG0572	uridine kinase
HVX61_14195	COG5002	protein histidine kinase activity
HVX61_14195	COG5001	Diguanylate cyclase
HVX61_14195	COG3447	MASE1 domain protein
HVX61_14200	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
HVX61_14205	COG0443	Heat shock 70 kDa protein
HVX61_14210	COG4248	protein with protein kinase and helix-hairpin-helix DNA-binding domains
HVX61_14215	COG0631	protein serine/threonine phosphatase activity
HVX61_14220	COG4245	von Willebrand factor, type A
HVX61_14235	COG2246	polysaccharide biosynthetic process
HVX61_14260	COG2801	Transposase and inactivated derivatives
HVX61_14285	COG2205	protein histidine kinase activity
HVX61_14290	COG0745	RESPONSE REGULATOR receiver
HVX61_14300	COG3609	addiction module antidote protein, CC2985 family
HVX61_14375	COG5301	cellulose 1,4-beta-cellobiosidase activity
HVX61_14375	COG5301	cellulose 1,4-beta-cellobiosidase activity
HVX61_14470	COG4695	Portal protein
HVX61_14540	COG4974	Belongs to the 'phage' integrase family
HVX61_14560	COG1063	alcohol dehydrogenase
HVX61_14565	COG3775	system Galactitol-specific IIC component
HVX61_14570	COG3414	Phosphotransferase system galactitol-specific IIB component
HVX61_14575	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HVX61_14590	COG1830	Aldolase
HVX61_14595	COG2211	Major facilitator Superfamily
HVX61_14600	COG1397	ADP-ribosylglycohydrolase
HVX61_14605	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HVX61_14610	COG2188	Transcriptional regulator
HVX61_14615	COG3757	hydrolase, family 25
HVX61_14620	COG0351	phosphomethylpyrimidine kinase
HVX61_14640	COG5455	response to cobalt ion
HVX61_14645	COG3539	Fimbrial protein
HVX61_14650	COG3188	usher protein
HVX61_14655	COG3121	Chaperone
HVX61_14660	COG3539	Fimbrial protein
HVX61_14670	COG0489	protein tyrosine kinase activity
HVX61_14680	COG3831	ATPase activity
HVX61_14685	COG3831	ATPase activity
HVX61_14690	COG3831	ATPase activity
HVX61_14700	COG0714	Associated with various cellular activities
HVX61_14705	COG2425	protein containing a von Willebrand factor type A (vWA) domain
HVX61_14710	COG3552	Protein containing von Willebrand factor type A (VWA) domain
HVX61_14715	COG4715	Zinc finger, swim domain protein
HVX61_14720	COG4808	Protein conserved in bacteria
HVX61_14725	COG4807	Protein conserved in bacteria
HVX61_14730	COG3279	Response regulator of the LytR AlgR family
HVX61_14735	COG3275	phosphorelay sensor kinase activity
HVX61_14740	COG0789	Transcriptional regulator
HVX61_14750	COG1174	glycine betaine transport
HVX61_14755	COG1125	glycine betaine transport
HVX61_14760	COG1174	glycine betaine transport
HVX61_14765	COG1732	Glycine betaine
HVX61_14770	COG1472	Belongs to the glycosyl hydrolase 3 family
HVX61_14775	COG0277	FAD linked oxidase domain protein
HVX61_14780	COG1686	Belongs to the peptidase S11 family
HVX61_14790	COG0586	Pfam SNARE associated Golgi protein
HVX61_14795	COG1028	Short-chain dehydrogenase reductase Sdr
HVX61_14815	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HVX61_14820	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HVX61_14825	COG0625	glutathione transferase activity
HVX61_14840	COG2271	Major facilitator Superfamily
HVX61_14855	COG1346	cytolysis
HVX61_14865	COG2949	membrane
HVX61_14875	COG0493	'glutamate synthase
HVX61_14880	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
HVX61_14880	COG0167	dihydroorotate dehydrogenase activity
HVX61_14885	COG4211	Belongs to the binding-protein-dependent transport system permease family
HVX61_14890	COG1129	ABC transporter
HVX61_14895	COG1879	ABC-type sugar transport system periplasmic component
HVX61_14900	COG1609	Transcriptional regulator
HVX61_14905	COG2311	Membrane
HVX61_14915	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
HVX61_14920	COG4771	TonB-dependent receptor
HVX61_14925	COG0833	amino acid
HVX61_14930	COG0583	DNA-binding transcription factor activity
HVX61_14935	COG2855	membrane
HVX61_14945	COG1522	sequence-specific DNA binding
HVX61_14945	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HVX61_14950	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HVX61_14960	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HVX61_14965	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HVX61_14970	COG2313	pseudouridylate synthase activity
HVX61_14975	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HVX61_14980	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
HVX61_14980	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HVX61_14980	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HVX61_14985	COG1105	Belongs to the carbohydrate kinase PfkB family
HVX61_14990	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HVX61_14990	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HVX61_14995	COG2814	Major facilitator Superfamily
HVX61_15010	COG0246	Mannitol dehydrogenase
HVX61_15015	COG0523	cobalamin synthesis protein
HVX61_15020	COG0671	phosphoesterase, PA-phosphatase related
HVX61_15025	COG0791	NLP P60 protein
HVX61_15030	COG2200	EAL domain
HVX61_15035	COG4166	transmembrane transport
HVX61_15040	COG4174	ABC transporter (Permease)
HVX61_15045	COG4239	(ABC) transporter, permease
HVX61_15050	COG4172	Belongs to the ABC transporter superfamily
HVX61_15060	COG2814	Major facilitator Superfamily
HVX61_15065	COG1187	pseudouridine synthase activity
HVX61_15070	COG1061	Type III restriction enzyme res subunit
HVX61_15090	COG3083	sulfuric ester hydrolase activity
HVX61_15100	COG3468	outer membrane autotransporter barrel domain protein
HVX61_15105	COG2197	response regulator
HVX61_15110	COG3088	subunit of a heme lyase
HVX61_15110	COG4235	cytochrome complex assembly
HVX61_15115	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HVX61_15120	COG1138	Cytochrome C-type biogenesis protein
HVX61_15130	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HVX61_15135	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HVX61_15140	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HVX61_15145	COG4133	protoheme IX ABC transporter activity
HVX61_15150	COG3005	denitrification pathway
HVX61_15155	COG3043	anaerobic respiration
HVX61_15160	COG0348	domain, Protein
HVX61_15165	COG0437	4 iron, 4 sulfur cluster binding
HVX61_15175	COG3062	negative regulation of establishment of protein localization
HVX61_15180	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
HVX61_15180	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HVX61_15195	COG4615	Cyclic peptide transporter
HVX61_15200	COG3145	DNA-N1-methyladenine dioxygenase activity
HVX61_15205	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HVX61_15205	COG2169	Transcriptional regulator
HVX61_15210	COG1477	protein flavinylation
HVX61_15215	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HVX61_15220	COG0642	Histidine kinase
HVX61_15220	COG2198	Histidine kinase
HVX61_15225	COG2197	response regulator
HVX61_15230	COG0784	Response regulator, receiver
HVX61_15230	COG2205	protein histidine kinase activity
HVX61_15235	COG3852	Histidine kinase
HVX61_15240	COG2204	response regulator
HVX61_15245	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HVX61_15250	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HVX61_15255	COG2031	fatty acid transporter
HVX61_15260	COG0183	Belongs to the thiolase family
HVX61_15265	COG4676	Protein conserved in bacteria
HVX61_15270	COG5445	Predicted secreted protein (DUF2300)
HVX61_15275	COG2373	Large extracellular alpha-helical protein
HVX61_15280	COG3234	Protein of unknown function (DUF1175)
HVX61_15285	COG4685	Uncharacterized protein conserved in bacteria (DUF2138)
HVX61_15290	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HVX61_15300	COG3468	outer membrane autotransporter barrel domain protein
HVX61_15305	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HVX61_15310	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HVX61_15315	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HVX61_15320	COG3642	lipopolysaccharide core region biosynthetic process
HVX61_15325	COG2814	Major facilitator Superfamily
HVX61_15330	COG0583	DNA-binding transcription factor activity
HVX61_15335	COG0584	glycerophosphoryl diester phosphodiesterase
HVX61_15340	COG2271	Major facilitator Superfamily
HVX61_15345	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HVX61_15355	COG0247	lactate metabolic process
HVX61_15360	COG5464	transposase or invertase
HVX61_15370	COG3836	Belongs to the HpcH HpaI aldolase family
HVX61_15375	COG2271	Major facilitator Superfamily
HVX61_15385	COG1414	Transcriptional regulator
HVX61_15450	COG0318	PFAM AMP-dependent synthetase and ligase
HVX61_15460	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
HVX61_15475	COG1169	isochorismate synthase
HVX61_15480	COG4575	ribosome binding
HVX61_15485	COG2153	protein acetylation
HVX61_15500	COG2304	oxidoreductase activity
HVX61_15520	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HVX61_15525	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HVX61_15535	COG0839	Belongs to the complex I subunit 6 family
HVX61_15550	COG1034	ATP synthesis coupled electron transport
HVX61_15555	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
HVX61_15560	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
HVX61_15580	COG0583	DNA-binding transcription factor activity
HVX61_15585	COG0436	Aminotransferase
HVX61_15595	COG0490	domain, Protein
HVX61_15595	COG0471	metal ion transport
HVX61_15600	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HVX61_15615	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HVX61_15620	COG0857	belongs to the CobB CobQ family
HVX61_15620	COG0280	phosphate acetyltransferase
HVX61_15625	COG1288	antiporter activity
HVX61_15630	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
HVX61_15635	COG0622	Phosphoesterase
HVX61_15640	COG0625	glutathione transferase activity
HVX61_15645	COG0625	glutathione transferase activity
HVX61_15650	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HVX61_15655	COG1090	epimerase
HVX61_15660	COG5464	transposase or invertase
HVX61_15665	COG4598	ABC transporter
HVX61_15670	COG4160	amino acid transport
HVX61_15675	COG4215	(ABC) transporter
HVX61_15680	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HVX61_15685	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HVX61_15690	COG0163	prenyltransferase activity
HVX61_15695	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HVX61_15700	COG1286	toxin biosynthetic process
HVX61_15705	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
HVX61_15710	COG0285	dihydrofolate synthase activity
HVX61_15720	COG0586	Pfam SNARE associated Golgi protein
HVX61_15730	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HVX61_15745	COG2814	Major facilitator Superfamily
HVX61_15750	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HVX61_15765	COG3101	peptidyl-lysine hydroxylation
HVX61_15770	COG0730	response to heat
HVX61_15785	COG2890	protein-(glutamine-N5) methyltransferase activity
HVX61_15800	COG3539	Fimbrial protein
HVX61_15805	COG3539	Fimbrial protein
HVX61_15810	COG3539	Fimbrial protein
HVX61_15815	COG3121	Chaperone
HVX61_15820	COG3188	usher protein
HVX61_15825	COG3539	Fimbrial protein
HVX61_15830	COG2062	phosphohistidine phosphatase, SixA
HVX61_15845	COG3691	Protein conserved in bacteria
HVX61_15850	COG2067	long-chain fatty acid transport protein
HVX61_15860	COG2853	Lipoprotein
HVX61_15865	COG2116	formate transmembrane transporter activity
HVX61_15910	COG0477	Major facilitator Superfamily
HVX61_15915	COG1566	PFAM secretion protein HlyD family protein
HVX61_15920	COG2197	response regulator
HVX61_15925	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HVX61_15925	COG2205	protein histidine kinase activity
HVX61_15925	COG2198	Histidine kinase
HVX61_15925	COG0784	Response regulator, receiver
HVX61_15930	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HVX61_15935	COG0679	Auxin Efflux Carrier
HVX61_15940	COG0028	Belongs to the TPP enzyme family
HVX61_15965	COG1560	Kdo2-lipid A biosynthetic process
HVX61_15975	COG0436	Aminotransferase
HVX61_15980	COG3275	phosphorelay sensor kinase activity
HVX61_15985	COG3279	Response regulator of the LytR AlgR family
HVX61_15990	COG2207	Transcriptional regulator
HVX61_15995	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HVX61_15995	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HVX61_15995	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HVX61_16000	COG1363	Peptidase, m42
HVX61_16005	COG0006	proline dipeptidase activity
HVX61_16010	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HVX61_16015	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HVX61_16040	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HVX61_16045	COG2200	EAL domain
HVX61_16045	COG2199	diguanylate cyclase activity
HVX61_16060	COG3415	Transposase
HVX61_16065	COG3415	Transposase
HVX61_16100	COG0583	DNA-binding transcription factor activity
HVX61_16105	COG0385	Bile acid
HVX61_16110	COG3530	Putative quorum-sensing-regulated virulence factor
HVX61_16130	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HVX61_16135	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HVX61_16140	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HVX61_16145	COG2190	(PTS) system
HVX61_16160	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HVX61_16165	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
HVX61_16170	COG4208	sulfate ABC transporter
HVX61_16175	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
HVX61_16180	COG4150	thiosulfate binding
HVX61_16185	COG1028	Short-chain dehydrogenase reductase Sdr
HVX61_16200	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HVX61_16200	COG1263	PTS System
HVX61_16205	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HVX61_16210	COG2837	iron assimilation
HVX61_16230	COG0860	N-Acetylmuramoyl-L-alanine amidase
HVX61_16240	COG2207	Transcriptional regulator
HVX61_16245	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
HVX61_16250	COG4816	utilization protein
HVX61_16260	COG4303	Ethanolamine ammonia lyase large subunit
HVX61_16265	COG4819	ethanolamine utilization protein
HVX61_16270	COG3192	ethanolamine utilization protein
HVX61_16275	COG1454	alcohol dehydrogenase
HVX61_16280	COG4820	ethanolamine utilization protein (EutJ)
HVX61_16285	COG1012	belongs to the aldehyde dehydrogenase family
HVX61_16290	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
HVX61_16295	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
HVX61_16300	COG0280	phosphate acetyltransferase
HVX61_16305	COG4812	Cobalamin adenosyltransferase
HVX61_16310	COG4766	ethanolamine catabolic process
HVX61_16315	COG4917	ethanolamine utilization protein
HVX61_16320	COG4810	utilization protein
HVX61_16325	COG0281	malic enzyme
HVX61_16325	COG0280	phosphate acetyltransferase
HVX61_16330	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HVX61_16335	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HVX61_16345	COG5342	invasion associated locus B
HVX61_16355	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HVX61_16355	COG0493	'glutamate synthase
HVX61_16360	COG3850	Histidine kinase
HVX61_16365	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HVX61_16375	COG1393	Belongs to the ArsC family
HVX61_16390	COG0400	carboxylic ester hydrolase activity
HVX61_16400	COG2321	neutral zinc metallopeptidase
HVX61_16420	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
HVX61_16430	COG2716	regulation of RNA biosynthetic process
HVX61_16435	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HVX61_16440	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HVX61_16445	COG0651	ATP synthesis coupled electron transport
HVX61_16450	COG0650	Formate hydrogenlyase subunit 4
HVX61_16455	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HVX61_16460	COG4237	Hydrogenase 4 membrane
HVX61_16465	COG0651	ATP synthesis coupled electron transport
HVX61_16470	COG3261	NADH dehydrogenase
HVX61_16470	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
HVX61_16475	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HVX61_16480	COG3260	NADH ubiquinone oxidoreductase 20
HVX61_16490	COG3604	Transcriptional regulator
HVX61_16495	COG2116	formate transmembrane transporter activity
HVX61_16500	COG0628	permease
HVX61_16505	COG4783	chaperone-mediated protein folding
HVX61_16510	COG1393	Belongs to the ArsC family
HVX61_16520	COG2233	PERMEase
HVX61_16535	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HVX61_16540	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
HVX61_16545	COG0248	Ppx GppA phosphatase
HVX61_16550	COG2200	EAL domain
HVX61_16565	COG3133	Outer membrane lipoprotein
HVX61_16580	COG0517	IMP dehydrogenase activity
HVX61_16580	COG0516	GMP reductase activity
HVX61_16605	COG1645	bacterial-type flagellum-dependent swarming motility
HVX61_16620	COG2976	Protein conserved in bacteria
HVX61_16650	COG4953	penicillin-binding protein 1C
HVX61_16655	COG2373	Large extracellular alpha-helical protein
HVX61_16660	COG2897	thiosulfate sulfurtransferase activity
HVX61_16675	COG2975	iron-sulfur cluster assembly
HVX61_16680	COG0633	Ferredoxin
HVX61_16700	COG0822	iron-sulfur transferase activity
HVX61_16720	COG0483	inositol monophosphate 1-phosphatase activity
HVX61_16725	COG1073	alpha beta
HVX61_16730	COG3711	transcriptional antiterminator
HVX61_16735	COG2814	Major facilitator Superfamily
HVX61_16740	COG0583	DNA-binding transcription factor activity
HVX61_16745	COG4638	Rieske (2fe-2S)
HVX61_16770	COG2259	Doxx family
HVX61_16775	COG2017	converts alpha-aldose to the beta-anomer
HVX61_16780	COG1063	alcohol dehydrogenase
HVX61_16785	COG1172	Belongs to the binding-protein-dependent transport system permease family
HVX61_16790	COG1129	ABC transporter
HVX61_16795	COG1879	ABC-type sugar transport system periplasmic component
HVX61_16800	COG0457	Tetratricopeptide repeat
HVX61_16805	COG1940	carbohydrate kinase activity
HVX61_16815	COG1017	nitric oxide dioxygenase activity
HVX61_16815	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HVX61_16820	COG0347	Belongs to the P(II) protein family
HVX61_16825	COG2204	response regulator
HVX61_16830	COG3170	Tfp pilus assembly protein FimV
HVX61_16835	COG2205	protein histidine kinase activity
HVX61_16840	COG0047	phosphoribosylformylglycinamidine synthase activity
HVX61_16840	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HVX61_16850	COG0590	tRNA wobble adenosine to inosine editing
HVX61_16855	COG0560	Phosphoserine phosphatase
HVX61_16860	COG1737	Transcriptional regulator
HVX61_16865	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HVX61_16880	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
HVX61_16900	COG0681	Belongs to the peptidase S26 family
HVX61_16910	COG3086	response to oxidative stress
HVX61_16915	COG3026	antisigma factor binding
HVX61_16920	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
HVX61_16925	COG1595	DNA-templated transcription, initiation
HVX61_16935	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HVX61_16945	COG0513	Belongs to the DEAD box helicase family
HVX61_16950	COG0583	DNA-binding transcription factor activity
HVX61_16955	COG1280	lysine exporter protein (LysE YggA)
HVX61_16975	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HVX61_16980	COG3118	belongs to the thioredoxin family
HVX61_16990	COG0045	succinate-CoA ligase (ADP-forming) activity
HVX61_16990	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HVX61_16990	COG1042	CoA-binding domain protein
HVX61_16995	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HVX61_17000	COG5544	Lipoprotein
HVX61_17005	COG0477	Major facilitator Superfamily
HVX61_17030	COG0542	response to heat
HVX61_17040	COG0564	pseudouridine synthase activity
HVX61_17045	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HVX61_17050	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HVX61_17060	COG0077	Prephenate dehydratase
HVX61_17060	COG1605	Chorismate mutase
HVX61_17065	COG1605	Chorismate mutase
HVX61_17065	COG0287	Prephenate dehydrogenase
HVX61_17070	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HVX61_17085	COG2199	diguanylate cyclase activity
HVX61_17090	COG2885	chlorophyll binding
HVX61_17115	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HVX61_17120	COG4137	Cytochrome C assembly protein
HVX61_17140	COG0497	DNA recombination
HVX61_17145	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HVX61_17155	COG2867	negative regulation of translational initiation
HVX61_17170	COG0582	viral genome integration into host DNA
HVX61_17240	COG3468	outer membrane autotransporter barrel domain protein
HVX61_17275	COG1195	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP
HVX61_17300	COG4983	Phage plasmid primase, P4 family domain protein
HVX61_17325	COG3596	GTP binding
HVX61_17330	COG2378	regulation of single-species biofilm formation
HVX61_17340	COG2378	regulation of single-species biofilm formation
HVX61_17365	COG2003	Belongs to the UPF0758 family
HVX61_17390	COG0366	Alpha amylase catalytic
HVX61_17400	COG0579	oxidoreductase
HVX61_17405	COG1012	belongs to the aldehyde dehydrogenase family
HVX61_17410	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HVX61_17415	COG1113	amino acid transport
HVX61_17420	COG1802	Transcriptional regulator
HVX61_17425	COG1652	LysM domain
HVX61_17430	COG0401	homolog of Blt101
HVX61_17435	COG0640	Transcriptional regulator
HVX61_17440	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HVX61_17445	COG2916	Histone family protein nucleoid-structuring protein H-NS
HVX61_17460	COG4575	ribosome binding
HVX61_17465	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HVX61_17475	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HVX61_17480	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HVX61_17485	COG4175	Glycine betaine
HVX61_17490	COG4176	ABC-type proline glycine betaine transport system permease component
HVX61_17495	COG2113	Glycine betaine
HVX61_17500	COG2814	Major facilitator Superfamily
HVX61_17505	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
HVX61_17515	COG1846	Transcriptional regulator
HVX61_17520	COG1566	PFAM secretion protein HlyD family protein
HVX61_17525	COG2814	Major facilitator Superfamily
HVX61_17540	COG1238	metal cluster binding
HVX61_17545	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HVX61_17575	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
HVX61_17595	COG1546	Belongs to the CinA family
HVX61_17600	COG2951	lytic endotransglycosylase activity
HVX61_17605	COG3730	PTS system glucitol sorbitol-specific
HVX61_17610	COG3732	PTS system glucitol sorbitol-specific
HVX61_17620	COG1028	Short-chain dehydrogenase reductase Sdr
HVX61_17625	COG4578	phosphoenolpyruvate-dependent sugar phosphotransferase system
HVX61_17630	COG1349	DNA-binding transcription factor activity
HVX61_17655	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
HVX61_17660	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HVX61_17665	COG1609	Transcriptional regulator
HVX61_17670	COG1263	PTS System
HVX61_17670	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HVX61_17675	COG2723	6-phospho-beta-galactosidase activity
HVX61_17680	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
HVX61_17690	COG3260	NADH ubiquinone oxidoreductase 20
HVX61_17695	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HVX61_17700	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
HVX61_17700	COG3261	NADH dehydrogenase
HVX61_17705	COG0650	Formate hydrogenlyase subunit 4
HVX61_17710	COG0651	ATP synthesis coupled electron transport
HVX61_17715	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HVX61_17725	COG0375	protein maturation
HVX61_17730	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
HVX61_17735	COG0298	carbon dioxide binding
HVX61_17740	COG0409	Hydrogenase expression formation protein
HVX61_17745	COG0309	Hydrogenase expression formation protein (HypE)
HVX61_17750	COG3604	Transcriptional regulator
HVX61_17775	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HVX61_17780	COG1349	DNA-binding transcription factor activity
HVX61_17785	COG2084	Dehydrogenase
HVX61_17790	COG3395	kinase activity
HVX61_17795	COG0235	Class ii aldolase
HVX61_17800	COG3622	Belongs to the hyi family
HVX61_17805	COG2610	gluconate transmembrane transporter activity
HVX61_17815	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HVX61_17820	COG0163	prenyltransferase activity
HVX61_17835	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HVX61_17840	COG4942	peptidase
HVX61_17840	COG1388	LysM domain
HVX61_17895	COG2234	aminopeptidase activity
HVX61_17900	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HVX61_17905	COG1518	maintenance of DNA repeat elements
HVX61_17920	COG1857	crispr-associated protein
HVX61_17935	COG1203	CRISPR-associated helicase, Cas3
HVX61_17955	COG0720	synthase
HVX61_17960	COG0644	oxidoreductase
HVX61_17965	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
HVX61_17970	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
HVX61_17975	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
HVX61_17980	COG2086	electron transfer activity
HVX61_17985	COG0477	Major facilitator Superfamily
HVX61_17990	COG0277	FAD linked oxidase domain protein
HVX61_17995	COG1028	Short-chain dehydrogenase reductase Sdr
HVX61_18000	COG2223	nitrite transmembrane transporter activity
HVX61_18005	COG1070	Carbohydrate kinase
HVX61_18010	COG0602	queuosine metabolic process
HVX61_18020	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
HVX61_18030	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
HVX61_18045	COG3956	TIGRFAM MazG family protein
HVX61_18050	COG2337	Toxic component of a toxin-antitoxin (TA) module
HVX61_18055	COG2336	PFAM SpoVT AbrB
HVX61_18060	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HVX61_18070	COG3850	Histidine kinase
HVX61_18070	COG3437	response regulator, receiver
HVX61_18070	COG2205	protein histidine kinase activity
HVX61_18070	COG4999	Histidine kinase
HVX61_18075	COG4948	Mandelate Racemase Muconate Lactonizing
HVX61_18080	COG4948	Mandelate Racemase Muconate Lactonizing
HVX61_18085	COG2271	Major facilitator Superfamily
HVX61_18090	COG0716	FMN binding
HVX61_18095	COG0564	pseudouridine synthase activity
HVX61_18100	COG3098	single-species biofilm formation
HVX61_18115	COG1611	Belongs to the LOG family
HVX61_18120	COG0814	amino acid
HVX61_18125	COG1760	l-serine dehydratase
HVX61_18135	COG1454	alcohol dehydrogenase
HVX61_18140	COG0235	Class ii aldolase
HVX61_18145	COG0738	Major facilitator superfamily
HVX61_18155	COG1070	Carbohydrate kinase
HVX61_18165	COG1349	DNA-binding transcription factor activity
HVX61_18175	COG2363	Small membrane protein
HVX61_18180	COG0583	DNA-binding transcription factor activity
HVX61_18190	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HVX61_18195	COG2166	iron-sulfur cluster assembly
HVX61_18200	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HVX61_18205	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
HVX61_18225	COG0860	N-Acetylmuramoyl-L-alanine amidase
HVX61_18230	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
HVX61_18230	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HVX61_18235	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HVX61_18240	COG1074	ATP-dependent DNA helicase activity
HVX61_18245	COG1025	Belongs to the peptidase M16 family
HVX61_18250	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
HVX61_18255	COG4967	type IV pilus modification protein PilV
HVX61_18265	COG4795	General secretion pathway protein
HVX61_18270	COG2165	general secretion pathway protein
HVX61_18285	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
HVX61_18300	COG0861	Integral membrane protein TerC family
HVX61_18310	COG0667	Aldo Keto reductase
HVX61_18325	COG1609	Transcriptional regulator
HVX61_18335	COG0583	DNA-binding transcription factor activity
HVX61_18340	COG1794	racemase activity, acting on amino acids and derivatives
HVX61_18345	COG2814	Major facilitator Superfamily
HVX61_18355	COG1028	Short-chain dehydrogenase reductase Sdr
HVX61_18365	COG0183	Belongs to the thiolase family
HVX61_18370	COG0814	amino acid
HVX61_18375	COG2771	luxR family
HVX61_18380	COG3710	Transcriptional regulator
HVX61_18405	COG0457	Tetratricopeptide repeat
HVX61_18410	COG0457	Tetratricopeptide repeat
HVX61_18410	COG3710	Transcriptional regulator
HVX61_18420	COG0741	lytic transglycosylase activity
HVX61_18425	COG2197	response regulator
HVX61_18525	COG2207	Transcriptional regulator
HVX61_18535	COG3387	PFAM Glycoside hydrolase 15-related
HVX61_18545	COG4942	peptidase
HVX61_18550	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HVX61_18555	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
HVX61_18560	COG2080	2 iron, 2 sulfur cluster binding
HVX61_18570	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HVX61_18575	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HVX61_18580	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HVX61_18590	COG0549	Belongs to the carbamate kinase family
HVX61_18595	COG3608	succinylglutamate desuccinylase aspartoacylase
HVX61_18595	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
HVX61_18600	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HVX61_18605	COG2068	MobA-Related Protein
HVX61_18610	COG0493	'glutamate synthase
HVX61_18610	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HVX61_18615	COG0402	S-adenosylhomocysteine deaminase activity
HVX61_18620	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
HVX61_18625	COG2080	2 iron, 2 sulfur cluster binding
HVX61_18625	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HVX61_18630	COG2233	PERMEase
HVX61_18635	COG0402	S-adenosylhomocysteine deaminase activity
HVX61_18640	COG2252	PERMEase
HVX61_18645	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HVX61_18655	COG2233	PERMEase
HVX61_18685	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HVX61_18690	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HVX61_18695	COG4974	Belongs to the 'phage' integrase family
HVX61_18700	COG0716	FMN binding
HVX61_18710	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
HVX61_18720	COG1272	protein, Hemolysin III
HVX61_18730	COG2723	6-phospho-beta-galactosidase activity
HVX61_18735	COG1028	Short-chain dehydrogenase reductase Sdr
HVX61_18760	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HVX61_18765	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HVX61_18770	COG0006	proline dipeptidase activity
HVX61_18790	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HVX61_18800	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HVX61_18815	COG1182	Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity
HVX61_18825	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HVX61_18835	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HVX61_18835	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HVX61_18840	COG1703	isobutyryl-CoA mutase activity
HVX61_18845	COG1024	Enoyl-CoA hydratase
HVX61_18855	COG0583	DNA-binding transcription factor activity
HVX61_18860	COG2968	Membrane
HVX61_18865	COG1279	arginine transmembrane transporter activity
HVX61_18870	COG0668	transmembrane transport
HVX61_18875	COG0191	fructose-bisphosphate aldolase activity
HVX61_18890	COG1072	(Pantothenic acid kinase))
HVX61_18900	COG1494	fructose-1,6-bisphosphatase
HVX61_18905	COG1063	alcohol dehydrogenase
HVX61_18910	COG2213	PTS system mannitol-specific
HVX61_18915	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HVX61_18920	COG0330	HflC and HflK could
HVX61_18925	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HVX61_18930	COG0501	Belongs to the peptidase M48B family
HVX61_18945	COG1166	arginine decarboxylase activity
HVX61_18965	COG2814	Major facilitator Superfamily
HVX61_18975	COG2356	endonuclease I
HVX61_18980	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HVX61_18985	COG0189	ligase activity
HVX61_19000	COG2805	Type II/IV secretion system protein
HVX61_19005	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HVX61_19010	COG0762	integral membrane protein
HVX61_19025	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HVX61_19035	COG0252	asparaginase activity
HVX61_19045	COG3171	Protein conserved in bacteria
HVX61_19055	COG1194	a g-specific adenine glycosylase
HVX61_19070	COG2211	Major facilitator Superfamily
HVX61_19075	COG1982	Orn Lys Arg decarboxylase major
HVX61_19080	COG1811	Na channel or pump
HVX61_19325	COG4964	Belongs to the GSP D family
HVX61_19350	COG1620	l-lactate permease
HVX61_19355	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
HVX61_19360	COG3193	protein, possibly involved in utilization of glycolate and propanediol
HVX61_19365	COG0247	lactate metabolic process
HVX61_19370	COG0277	FAD linked oxidase domain protein
HVX61_19375	COG0277	FAD linked oxidase domain protein
HVX61_19380	COG2186	Transcriptional regulator
HVX61_19385	COG0456	acetyltransferase
HVX61_19390	COG0318	PFAM AMP-dependent synthetase and ligase
HVX61_19400	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HVX61_19405	COG0156	8-amino-7-oxononanoate synthase activity
HVX61_19415	COG0795	lipopolysaccharide-transporting ATPase activity
HVX61_19420	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
HVX61_19430	COG2244	polysaccharide biosynthetic process
HVX61_19435	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HVX61_19440	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HVX61_19445	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HVX61_19450	COG0306	phosphate transporter
HVX61_19455	COG0754	glutathionylspermidine amidase activity
HVX61_19460	COG0625	glutathione transferase activity
HVX61_19465	COG0298	carbon dioxide binding
HVX61_19475	COG1773	rubredoxin
HVX61_19480	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
HVX61_19485	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
HVX61_19490	COG5557	Pfam Polysulphide reductase, NrfD
HVX61_19495	COG0437	4 iron, 4 sulfur cluster binding
HVX61_19500	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
HVX61_19515	COG0667	Aldo Keto reductase
HVX61_19525	COG1028	Short-chain dehydrogenase reductase Sdr
HVX61_19530	COG0848	biopolymer transport protein
HVX61_19535	COG0811	peptide transport
HVX61_19540	COG0626	cystathionine gamma-synthase activity
HVX61_19545	COG0586	Pfam SNARE associated Golgi protein
HVX61_19550	COG2207	Transcriptional regulator
HVX61_19555	COG1979	alcohol dehydrogenase
HVX61_19560	COG0656	L-ascorbic acid biosynthetic process
HVX61_19570	COG4238	major outer membrane lipoprotein
HVX61_19575	COG1032	radical SAM domain protein
HVX61_19580	COG2132	Multicopper oxidase
HVX61_19585	COG0204	Acyl-transferase
HVX61_19590	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HVX61_19595	COG4166	transmembrane transport
HVX61_19600	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
HVX61_19605	COG3111	PFAM Bacterial OB fold (BOF) protein
HVX61_19610	COG0745	RESPONSE REGULATOR receiver
HVX61_19615	COG0642	Histidine kinase
HVX61_19620	COG2249	NAD(P)H dehydrogenase (quinone) activity
HVX61_19625	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
HVX61_19630	COG0187	DNA topoisomerase II activity
HVX61_19635	COG3150	esterase
HVX61_19640	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HVX61_19645	COG3151	Protein conserved in bacteria
HVX61_19650	COG0494	nUDIX hydrolase
HVX61_19655	COG1538	Outer membrane efflux protein
HVX61_19665	COG0754	glutathionylspermidine amidase activity
HVX61_19670	COG3384	dioxygenase
HVX61_19700	COG1585	Membrane protein implicated in regulation of membrane protease activity
HVX61_19705	COG2268	Band 7 protein
HVX61_19730	COG3025	triphosphatase activity
HVX61_19735	COG4991	sh3 domain protein
HVX61_19750	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HVX61_19765	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
HVX61_19770	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HVX61_19775	COG0471	metal ion transport
HVX61_19785	COG0828	Belongs to the bacterial ribosomal protein bS21 family
HVX61_19790	COG0358	DNA primase activity
HVX61_19795	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HVX61_19810	COG2375	cellular response to nickel ion
HVX61_19815	COG1695	Transcriptional regulator
HVX61_19820	COG0840	transmembrane signaling receptor activity
HVX61_19830	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HVX61_19835	COG1609	Transcriptional regulator
HVX61_19840	COG3250	beta-galactosidase activity
HVX61_19845	COG2731	YhcH YjgK YiaL family protein
HVX61_19850	COG0531	amino acid
HVX61_19860	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
HVX61_19860	COG3408	Glycogen debranching enzyme
HVX61_19865	COG1902	pentaerythritol trinitrate reductase activity
HVX61_19865	COG0446	pyridine nucleotide-disulphide oxidoreductase
HVX61_19870	COG5499	transcription regulator containing HTH domain
HVX61_19885	COG1451	nucleotide metabolic process
HVX61_19890	COG2949	membrane
HVX61_19895	COG0673	inositol 2-dehydrogenase activity
HVX61_19900	COG0861	Integral membrane protein TerC family
HVX61_19905	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
HVX61_19915	COG2721	sulfolactate sulfo-lyase activity
HVX61_19925	COG2271	Major facilitator Superfamily
HVX61_19930	COG2186	Transcriptional regulator
HVX61_19935	COG0586	Pfam SNARE associated Golgi protein
HVX61_19945	COG1422	Protein of unknown function (DUF1090)
HVX61_19950	COG4575	ribosome binding
HVX61_19955	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
HVX61_19965	COG2259	Doxx family
HVX61_19970	COG0435	Glutathione S-transferase
HVX61_19975	COG3152	Membrane
HVX61_19980	COG3152	Membrane
HVX61_19985	COG0583	DNA-binding transcription factor activity
HVX61_19990	COG1741	Belongs to the pirin family
HVX61_20005	COG0814	amino acid
HVX61_20010	COG1760	l-serine dehydratase
HVX61_20015	COG0251	oxidation-reduction process
HVX61_20020	COG1882	Formate acetyltransferase
HVX61_20025	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HVX61_20035	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HVX61_20040	COG0583	DNA-binding transcription factor activity
HVX61_20065	COG1929	Belongs to the glycerate kinase type-1 family
HVX61_20070	COG2084	Dehydrogenase
HVX61_20080	COG2271	Major facilitator Superfamily
HVX61_20085	COG2721	sulfolactate sulfo-lyase activity
HVX61_20090	COG2002	toxin-antitoxin pair type II binding
HVX61_20100	COG1349	DNA-binding transcription factor activity
HVX61_20110	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HVX61_20120	COG3716	PTS system mannose fructose sorbose family IID component
HVX61_20125	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HVX61_20130	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HVX61_20135	COG2222	sugar isomerase
HVX61_20145	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HVX61_20150	COG3715	PTS system
HVX61_20155	COG3716	PTS system mannose fructose sorbose family IID component
HVX61_20160	COG0363	glucosamine-6-phosphate deaminase activity
HVX61_20175	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HVX61_20180	COG3107	peptidoglycan biosynthetic process
HVX61_20195	COG2823	Periplasmic or secreted lipoprotein
HVX61_20200	COG0701	Predicted permease
HVX61_20205	COG0702	epimerase
HVX61_20210	COG0693	protein deglycase activity
HVX61_20225	COG3153	acetyltransferase
HVX61_20230	COG3154	lipid carrier protein
HVX61_20235	COG0826	peptidase U32
HVX61_20240	COG0826	peptidase U32
HVX61_20245	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HVX61_20250	COG0814	amino acid
HVX61_20255	COG0513	Belongs to the DEAD box helicase family
HVX61_20295	COG0195	Participates in both transcription termination and antitermination
HVX61_20315	COG2194	sulfuric ester hydrolase activity
HVX61_20325	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HVX61_20335	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HVX61_20340	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HVX61_20350	COG1534	Rna-binding protein
HVX61_20355	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HVX61_20360	COG2027	D-alanyl-D-alanine carboxypeptidase
HVX61_20370	COG0697	spore germination
HVX61_20385	COG0142	geranyltranstransferase activity
HVX61_20390	COG3423	Transcriptional regulator
HVX61_20400	COG5007	Belongs to the BolA IbaG family
HVX61_20405	COG3113	response to antibiotic
HVX61_20410	COG2854	intermembrane phospholipid transfer
HVX61_20415	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HVX61_20420	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HVX61_20425	COG1127	ABC transporter
HVX61_20430	COG0530	calcium, potassium:sodium antiporter activity
HVX61_20435	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HVX61_20435	COG0517	IMP dehydrogenase activity
HVX61_20440	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
HVX61_20445	COG3117	lipopolysaccharide transmembrane transporter activity
HVX61_20450	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
HVX61_20455	COG1137	ATPase activity
HVX61_20460	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
HVX61_20465	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HVX61_20480	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HVX61_20485	COG0515	serine threonine protein kinase
HVX61_20495	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
HVX61_20500	COG5002	protein histidine kinase activity
HVX61_20500	COG0784	Response regulator, receiver
HVX61_20500	COG2198	Histidine kinase
HVX61_20505	COG1242	4 iron, 4 sulfur cluster binding
HVX61_20510	COG0069	glutamate synthase activity
HVX61_20510	COG0070	glutamate synthase
HVX61_20510	COG0067	glutamate synthase
HVX61_20515	COG0493	'glutamate synthase
HVX61_20520	COG4804	nuclease activity
HVX61_20525	COG2731	YhcH YjgK YiaL family protein
HVX61_20555	COG3069	C4-dicarboxylate transmembrane transporter activity
HVX61_20560	COG2969	positive regulation of protein catabolic process
HVX61_20565	COG0625	glutathione transferase activity
HVX61_20580	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
HVX61_20585	COG3105	Protein conserved in bacteria
HVX61_20590	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HVX61_20595	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HVX61_20620	COG2732	(Barnase) inhibitor
HVX61_20640	COG0583	DNA-binding transcription factor activity
HVX61_20645	COG0312	modulator of DNA gyrase
HVX61_20650	COG3164	Protein of unknown function
HVX61_20655	COG1530	ribonuclease E activity
HVX61_20665	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
HVX61_20670	COG1792	Involved in formation and maintenance of cell shape
HVX61_20675	COG1077	Cell shape determining protein MreB Mrl
HVX61_20680	COG2200	EAL domain
HVX61_20680	COG2199	diguanylate cyclase activity
HVX61_20685	COG0604	alcohol dehydrogenase
HVX61_20690	COG0511	ligase activity, forming carbon-carbon bonds
HVX61_20695	COG0439	Biotin carboxylase
HVX61_20700	COG3924	membrane
HVX61_20705	COG4145	pantothenate transmembrane transporter activity
HVX61_20715	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HVX61_20725	COG2189	Belongs to the N(4) N(6)-methyltransferase family
HVX61_20735	COG1309	transcriptional regulator
HVX61_20740	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HVX61_20745	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HVX61_20755	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HVX61_20760	COG4597	amino acid ABC transporter
HVX61_20765	COG0765	amino acid transport
HVX61_20770	COG1126	abc transporter atp-binding protein
HVX61_20810	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HVX61_20825	COG0009	L-threonylcarbamoyladenylate synthase
HVX61_20830	COG0551	DNA topoisomerase type I activity
HVX61_20840	COG0758	DNA mediated transformation
HVX61_20860	COG0569	domain protein
HVX61_20870	COG3036	rescue of stalled ribosome
HVX61_20875	COG0789	Transcriptional regulator
HVX61_20915	COG0201	protein transport
HVX61_21005	COG0089	rRNA binding
HVX61_21075	COG2964	Protein conserved in bacteria
HVX61_21080	COG0545	Peptidyl-prolyl cis-trans isomerase
HVX61_21090	COG1047	Peptidyl-prolyl cis-trans
HVX61_21095	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
HVX61_21110	COG0488	(ABC) transporter
HVX61_21115	COG0429	hydrolase of the alpha beta-hydrolase fold
HVX61_21125	COG3954	Phosphoribulokinase
HVX61_21130	COG1765	OsmC-like protein
HVX61_21135	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HVX61_21140	COG1289	transmembrane transporter activity
HVX61_21145	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HVX61_21150	COG0512	Glutamine amidotransferase of anthranilate synthase
HVX61_21155	COG2184	nucleotidyltransferase activity
HVX61_21165	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HVX61_21175	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HVX61_21180	COG2146	nitrite reductase [NAD(P)H] activity
HVX61_21185	COG2116	formate transmembrane transporter activity
HVX61_21200	COG0531	amino acid
HVX61_21205	COG2222	sugar isomerase
HVX61_21210	COG1082	Xylose isomerase domain protein TIM barrel
HVX61_21220	COG2188	Transcriptional regulator
HVX61_21225	COG0180	Tryptophanyl-tRNA synthetase
HVX61_21230	COG0546	phosphoglycolate phosphatase activity
HVX61_21235	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HVX61_21240	COG0338	D12 class N6 adenine-specific DNA methyltransferase
HVX61_21245	COG3266	domain, Protein
HVX61_21260	COG4796	Type ii and iii secretion system protein
HVX61_21275	COG3166	PFAM Fimbrial assembly family protein
HVX61_21280	COG4972	Pilus assembly protein
HVX61_21285	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
HVX61_21290	COG0494	nUDIX hydrolase
HVX61_21300	COG1011	Hydrolase
HVX61_21305	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HVX61_21315	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
HVX61_21325	COG2205	protein histidine kinase activity
HVX61_21330	COG0745	RESPONSE REGULATOR receiver
HVX61_21335	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HVX61_21340	COG2183	response to ionizing radiation
HVX61_21345	COG1918	ferrous iron import across plasma membrane
HVX61_21350	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
HVX61_21360	COG5464	transposase or invertase
HVX61_21370	COG1040	competence protein
HVX61_21380	COG2610	gluconate transmembrane transporter activity
HVX61_21385	COG1640	4-alpha-glucanotransferase
HVX61_21390	COG0058	SHG alpha-glucan phosphorylase activity
HVX61_21415	COG1690	Belongs to the RtcB family
HVX61_21420	COG4650	regulator
HVX61_21425	COG1349	DNA-binding transcription factor activity
HVX61_21440	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HVX61_21455	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HVX61_21460	COG0058	SHG alpha-glucan phosphorylase activity
HVX61_21480	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HVX61_21485	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HVX61_21490	COG2095	MarC family integral membrane protein
HVX61_21500	COG0514	ATP-dependent DNA helicase (RecQ)
HVX61_21505	COG2610	gluconate transmembrane transporter activity
HVX61_21510	COG3265	gluconokinase activity
HVX61_21515	COG1609	Transcriptional regulator
HVX61_21520	COG1741	Belongs to the pirin family
HVX61_21525	COG0673	inositol 2-dehydrogenase activity
HVX61_21530	COG1247	-acetyltransferase
HVX61_21535	COG0405	Gamma-glutamyltransferase
HVX61_21545	COG0584	glycerophosphoryl diester phosphodiesterase
HVX61_21560	COG1175	transmembrane transport
HVX61_21565	COG1653	transport
HVX61_21570	COG0410	ABC transporter
HVX61_21575	COG0411	ABC transporter
HVX61_21580	COG4177	L-phenylalanine transmembrane transporter activity
HVX61_21585	COG0559	Belongs to the binding-protein-dependent transport system permease family
HVX61_21590	COG0683	leucine binding
HVX61_21595	COG0456	acetyltransferase
HVX61_21610	COG0683	leucine binding
HVX61_21615	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HVX61_21620	COG2177	Part of the ABC transporter FtsEX involved in
HVX61_21625	COG2884	Cell division ATP-binding protein ftsE
HVX61_21630	COG0552	protein localization to endoplasmic reticulum
HVX61_21635	COG0742	ribosomal rna small subunit methyltransferase
HVX61_21640	COG3776	membrane
HVX61_21650	COG3714	YhhN family
HVX61_21670	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
HVX61_21685	COG0628	permease
HVX61_21705	COG0204	Acyl-transferase
HVX61_21715	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HVX61_21735	COG1216	Glycosyl transferase, family 2
HVX61_21760	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HVX61_21770	COG1028	Short-chain dehydrogenase reductase Sdr
HVX61_21775	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HVX61_21780	COG2091	lysine biosynthetic process via aminoadipic acid
HVX61_21785	COG0747	negative chemotaxis
HVX61_21790	COG0601	transmembrane transport
HVX61_21795	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HVX61_21800	COG0444	Belongs to the ABC transporter superfamily
HVX61_21815	COG2188	Transcriptional regulator
HVX61_21825	COG3414	Phosphotransferase system galactitol-specific IIB component
HVX61_21830	COG3775	system Galactitol-specific IIC component
HVX61_21845	COG0191	fructose-bisphosphate aldolase activity
HVX61_21860	COG0842	Transport permease protein
HVX61_21865	COG0842	Transport permease protein
HVX61_21865	COG1129	ABC transporter
HVX61_21870	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HVX61_21890	COG2081	HI0933 family
HVX61_21895	COG0306	phosphate transporter
HVX61_21905	COG0589	response to stress
HVX61_21910	COG3104	oligopeptide transport
HVX61_21920	COG0339	signal peptide processing
HVX61_21925	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
HVX61_21930	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HVX61_21945	COG0640	Transcriptional regulator
HVX61_21950	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HVX61_21955	COG1393	Belongs to the ArsC family
HVX61_21975	COG3065	identical protein binding
HVX61_21980	COG2197	response regulator
HVX61_21985	COG3720	iron ion transport
HVX61_21990	COG4771	TonB-dependent receptor
HVX61_21995	COG4558	Periplasmic binding protein
HVX61_22005	COG3721	Heme iron utilization protein
HVX61_22015	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HVX61_22025	COG1285	pathogenesis
HVX61_22040	COG3247	response to pH
HVX61_22045	COG2771	luxR family
HVX61_22055	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HVX61_22060	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HVX61_22065	COG2207	Transcriptional regulator
HVX61_22075	COG0076	glutamate decarboxylase activity
HVX61_22080	COG1858	cytochrome C peroxidase
HVX61_22090	COG2197	response regulator
HVX61_22095	COG0583	DNA-binding transcription factor activity
HVX61_22100	COG1295	ribonuclease BN
HVX61_22105	COG0477	Major facilitator Superfamily
HVX61_22110	COG2982	Protein involved in outer membrane biogenesis
HVX61_22115	COG2200	EAL domain
HVX61_22125	COG0612	Peptidase, M16
HVX61_22135	COG2200	EAL domain
HVX61_22135	COG2199	diguanylate cyclase activity
HVX61_22140	COG0457	Tetratricopeptide repeat
HVX61_22140	COG3118	belongs to the thioredoxin family
HVX61_22145	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
HVX61_22150	COG1215	transferase activity, transferring glycosyl groups
HVX61_22155	COG1215	transferase activity, transferring glycosyl groups
HVX61_22180	COG2194	sulfuric ester hydrolase activity
HVX61_22205	COG0814	amino acid
HVX61_22210	COG4608	Belongs to the ABC transporter superfamily
HVX61_22215	COG0444	Belongs to the ABC transporter superfamily
HVX61_22220	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HVX61_22225	COG0601	transmembrane transport
HVX61_22235	COG0747	negative chemotaxis
HVX61_22245	COG2194	sulfuric ester hydrolase activity
HVX61_22250	COG3539	Fimbrial protein
HVX61_22255	COG3539	Fimbrial protein
HVX61_22265	COG3121	Chaperone
HVX61_22270	COG3539	Fimbrial protein
HVX61_22275	COG2223	nitrite transmembrane transporter activity
HVX61_22280	COG5571	outer membrane autotransporter
HVX61_22285	COG2818	Glycosylase
HVX61_22290	COG0456	acetyltransferase
HVX61_22295	COG0243	molybdopterin cofactor binding
HVX61_22300	COG2885	chlorophyll binding
HVX61_22315	COG2944	sequence-specific DNA binding
HVX61_22320	COG1278	Cold shock
HVX61_22345	COG3274	enterobacterial common antigen metabolic process
HVX61_22350	COG4682	membrane
HVX61_22355	COG4682	membrane
HVX61_22360	COG1070	Carbohydrate kinase
HVX61_22370	COG4213	ABC transporter substrate-binding protein
HVX61_22380	COG4214	carbohydrate transport
HVX61_22385	COG1609	Transcriptional regulator
HVX61_22385	COG2207	Transcriptional regulator
HVX61_22390	COG2992	FlgJ-related protein
HVX61_22395	COG0366	Alpha amylase catalytic
HVX61_22400	COG3977	Valine--pyruvate aminotransferase
HVX61_22405	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HVX61_22410	COG1414	Transcriptional regulator
HVX61_22420	COG2211	Major facilitator Superfamily
HVX61_22430	COG3713	MltA-interacting MipA family protein
HVX61_22435	COG0583	DNA-binding transcription factor activity
HVX61_22440	COG1566	PFAM secretion protein HlyD family protein
HVX61_22450	COG1012	belongs to the aldehyde dehydrogenase family
HVX61_22465	COG1454	alcohol dehydrogenase
HVX61_22470	COG3276	selenocysteine insertion sequence binding
HVX61_22480	COG0625	glutathione transferase activity
HVX61_22485	COG3210	domain, Protein
HVX61_22485	COG3468	outer membrane autotransporter barrel domain protein
HVX61_22530	COG1566	PFAM secretion protein HlyD family protein
HVX61_22540	COG2213	PTS system mannitol-specific
HVX61_22540	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HVX61_22550	COG3722	fumarate hydratase activity
HVX61_22570	COG5295	Hep Hag repeat protein
HVX61_22575	COG1620	l-lactate permease
HVX61_22580	COG2186	Transcriptional regulator
HVX61_22590	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HVX61_22595	COG1045	serine acetyltransferase
HVX61_22610	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HVX61_22615	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HVX61_22625	COG4942	peptidase
HVX61_22630	COG2861	carbohydrate metabolic process
HVX61_22635	COG1216	Glycosyl transferase, family 2
HVX61_22645	COG0156	8-amino-7-oxononanoate synthase activity
HVX61_22655	COG0859	PFAM glycosyl transferase family 9
HVX61_22660	COG0859	PFAM glycosyl transferase family 9
HVX61_22665	COG3307	-O-antigen
HVX61_22670	COG1216	Glycosyl transferase, family 2
HVX61_22675	COG1442	glycosyl transferase family 8
HVX61_22680	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HVX61_22695	COG0515	serine threonine protein kinase
HVX61_22700	COG0438	transferase activity, transferring glycosyl groups
HVX61_22705	COG0859	PFAM glycosyl transferase family 9
HVX61_22710	COG1519	Transferase
HVX61_22740	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HVX61_22770	COG1561	YicC-like family, N-terminal region
HVX61_22775	COG3645	SOS response
HVX61_22780	COG2860	membrane
HVX61_22790	COG0194	GDP metabolic process
HVX61_22800	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HVX61_22805	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HVX61_22810	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HVX61_22815	COG0786	glutamate:sodium symporter activity
HVX61_22820	COG2233	PERMEase
HVX61_22825	COG2982	Protein involved in outer membrane biogenesis
HVX61_22830	COG1501	Belongs to the glycosyl hydrolase 31 family
HVX61_22835	COG2211	Major facilitator Superfamily
HVX61_22845	COG0582	viral genome integration into host DNA
HVX61_22885	COG1560	Kdo2-lipid A biosynthetic process
HVX61_22890	COG2194	sulfuric ester hydrolase activity
HVX61_22895	COG0297	glycogen (starch) synthase activity
HVX61_22900	COG0726	polysaccharide deacetylase
HVX61_22905	COG3204	pilus organization
HVX61_22930	COG1388	LysM domain
HVX61_22930	COG4932	domain protein
HVX61_22930	COG2373	Large extracellular alpha-helical protein
HVX61_22940	COG0582	viral genome integration into host DNA
HVX61_22945	COG4974	Belongs to the 'phage' integrase family
HVX61_23020	COG3468	outer membrane autotransporter barrel domain protein
HVX61_23065	COG2003	Belongs to the UPF0758 family
HVX61_23105	COG2814	Major facilitator Superfamily
HVX61_23110	COG0697	spore germination
HVX61_23115	COG1464	Belongs to the NlpA lipoprotein family
HVX61_23125	COG0457	Tetratricopeptide repeat
HVX61_23155	COG2373	Large extracellular alpha-helical protein
HVX61_23155	COG4932	domain protein
HVX61_23155	COG1388	LysM domain
HVX61_23180	COG2252	PERMEase
HVX61_23190	COG1609	Transcriptional regulator
HVX61_23200	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HVX61_23205	COG2723	6-phospho-beta-galactosidase activity
HVX61_23210	COG1447	Phosphotransferase system cellobiose-specific component IIA
HVX61_23225	COG2271	Major facilitator Superfamily
HVX61_23230	COG2271	Major facilitator Superfamily
HVX61_23235	COG3851	Histidine kinase
HVX61_23240	COG2197	response regulator
HVX61_23255	COG0440	acetolactate synthase activity
HVX61_23260	COG0028	Belongs to the TPP enzyme family
HVX61_23275	COG2814	Major facilitator Superfamily
HVX61_23280	COG0641	radical SAM
HVX61_23290	COG2149	membrane
HVX61_23300	COG3119	arylsulfatase activity
HVX61_23305	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HVX61_23310	COG2207	Transcriptional regulator
HVX61_23325	COG2188	Transcriptional regulator
HVX61_23345	COG5645	(Lipo)protein
HVX61_23350	COG0823	Involved in the tonB-independent uptake of proteins
HVX61_23365	COG0561	phosphatase activity
HVX61_23370	COG3753	Protein conserved in bacteria
HVX61_23375	COG0187	DNA topoisomerase II activity
HVX61_23385	COG0592	DNA-directed DNA polymerase activity
HVX61_23440	COG0814	amino acid
HVX61_23455	COG2091	lysine biosynthetic process via aminoadipic acid
HVX61_23460	COG0431	NADPH-dependent FMN reductase
HVX61_23465	COG2252	PERMEase
HVX61_23470	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HVX61_23495	COG0704	Plays a role in the regulation of phosphate uptake
HVX61_23500	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HVX61_23505	COG0581	inorganic phosphate transmembrane transporter activity
HVX61_23510	COG0573	inorganic phosphate transmembrane transporter activity
HVX61_23515	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HVX61_23525	COG3539	Fimbrial protein
HVX61_23535	COG3121	Chaperone
HVX61_23545	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HVX61_23595	COG3312	ion transport
HVX61_23610	COG0716	FMN binding
HVX61_23615	COG1522	sequence-specific DNA binding
HVX61_23645	COG1129	ABC transporter
HVX61_23650	COG1172	Belongs to the binding-protein-dependent transport system permease family
HVX61_23655	COG1879	ABC-type sugar transport system periplasmic component
HVX61_23660	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HVX61_23665	COG1609	Transcriptional regulator
HVX61_23670	COG0477	Major facilitator Superfamily
HVX61_23675	COG2186	Transcriptional regulator
HVX61_23715	COG3085	chromosome segregation
HVX61_23720	COG0606	chelatase, subunit chli
HVX61_23740	COG3978	acetolactate synthase activity
HVX61_23745	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HVX61_23755	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HVX61_23760	COG0583	DNA-binding transcription factor activity
HVX61_23770	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HVX61_23775	COG3692	DNA binding
HVX61_23780	COG0210	DNA helicase
HVX61_23795	COG3118	belongs to the thioredoxin family
HVX61_23805	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
HVX61_23810	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HVX61_23815	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
HVX61_23820	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HVX61_23825	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
HVX61_23830	COG1088	dTDP-glucose 4,6-dehydratase activity
HVX61_23835	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
HVX61_23840	COG0456	acetyltransferase
HVX61_23845	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HVX61_23850	COG2244	polysaccharide biosynthetic process
HVX61_23870	COG1113	amino acid transport
HVX61_23895	COG0641	radical SAM
HVX61_23900	COG3119	arylsulfatase activity
HVX61_23905	COG3071	HemY protein
HVX61_23910	COG2959	enzyme of heme biosynthesis
HVX61_23915	COG1587	Uroporphyrinogen-III synthase
HVX61_23925	COG3072	Adenylate cyclase
HVX61_23955	COG5567	small periplasmic lipoprotein
HVX61_23965	COG3159	Protein conserved in bacteria
HVX61_23975	COG1011	Hydrolase
HVX61_23980	COG0210	DNA helicase
HVX61_23985	COG1912	Pfam S-adenosyl-l-methionine hydroxide adenosyltransferase
HVX61_23990	COG3698	Phosphodiester glycosidase
HVX61_23995	COG0598	Magnesium transport protein CorA
HVX61_24010	COG2962	Rard protein
HVX61_24015	COG2050	protein possibly involved in aromatic compounds catabolism
HVX61_24020	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
HVX61_24025	COG0514	ATP-dependent DNA helicase (RecQ)
HVX61_24030	COG1280	lysine exporter protein (LysE YggA)
HVX61_24040	COG1280	lysine exporter protein (LysE YggA)
HVX61_24045	COG2267	carboxylic ester hydrolase activity
HVX61_24050	COG0561	phosphatase activity
HVX61_24055	COG0697	spore germination
HVX61_24060	COG0583	DNA-binding transcription factor activity
HVX61_24070	COG0412	Dienelactone hydrolase
HVX61_24075	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
HVX61_24080	COG1322	Protein conserved in bacteria
HVX61_24090	COG3165	ubiquinone biosynthetic process from chorismate
HVX61_24100	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HVX61_24105	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HVX61_24110	COG0805	protein transport
HVX61_24120	COG0250	Participates in transcription elongation, termination and antitermination
HVX61_24125	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HVX61_24130	COG0543	2 iron, 2 sulfur cluster binding
HVX61_24150	COG1739	Uncharacterized protein family UPF0029
HVX61_24155	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HVX61_24160	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
HVX61_24190	COG1763	Mo-molybdopterin cofactor biosynthetic process
HVX61_24195	COG0746	molybdenum cofactor guanylyltransferase activity
HVX61_24200	COG3084	Protein conserved in bacteria
HVX61_24205	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HVX61_24210	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HVX61_24215	COG5339	Protein conserved in bacteria
HVX61_24220	COG0204	Acyl-transferase
HVX61_24225	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HVX61_24225	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HVX61_24235	COG3078	GTPase activator activity
HVX61_24240	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HVX61_24250	COG2204	response regulator
HVX61_24255	COG3852	Histidine kinase
HVX61_24260	COG0174	glutamine synthetase
HVX61_24270	COG2188	Transcriptional regulator
HVX61_24275	COG1082	Xylose isomerase domain protein TIM barrel
HVX61_24280	COG2271	Major facilitator Superfamily
HVX61_24290	COG1011	Hydrolase
HVX61_24305	COG0456	acetyltransferase
HVX61_24320	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
HVX61_24330	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HVX61_24335	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HVX61_24345	COG2864	formate dehydrogenase
HVX61_24350	COG0437	4 iron, 4 sulfur cluster binding
HVX61_24370	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HVX61_24370	COG3711	transcriptional antiterminator
HVX61_24375	COG1363	Peptidase, m42
HVX61_24380	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HVX61_24380	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HVX61_24385	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HVX61_24420	COG4977	sequence-specific DNA binding
HVX61_24420	COG1917	Cupin 2, conserved barrel domain protein
HVX61_24430	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HVX61_24440	COG2258	MOSC domain
HVX61_24445	COG2205	protein histidine kinase activity
HVX61_24450	COG0745	RESPONSE REGULATOR receiver
HVX61_24455	COG3678	ATP-independent chaperone mediated protein folding
HVX61_24460	COG4974	Belongs to the 'phage' integrase family
HVX61_24960	COG2963	transposase activity
HVX61_24985	COG3969	phosphoadenosine phosphosulfate
HVX61_24990	COG1475	DNA binding