locus-tag class description HVX74_00010 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) HVX74_00020 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HVX74_00025 ENOG4105VP5 Bacterial protein of unknown function (DUF937) HVX74_00030 ENOG410667J hydrolase HVX74_00035 ENOG410657R replicase EC 2.7 HVX74_00040 ENOG4105EMF GntR family transcriptional regulator HVX74_00045 ENOG4105EI3 2-dehydro-3-deoxygalactonokinase EC 2.7.1.58 HVX74_00050 ENOG4108RTU Aldolase HVX74_00060 ENOG4105DJB Major Facilitator Superfamily HVX74_00070 ENOG4105D99 atp gtp-binding protein HVX74_00075 ENOG4105R2A (LipO)protein HVX74_00095 ENOG4105FDP GntR family transcriptional regulator HVX74_00105 ENOG4108AHD Transcriptional regulator HVX74_00110 ENOG4107RUZ Sss sodium solute transporter superfamily HVX74_00115 ENOG4105CBG Sulfatase HVX74_00120 ENOG4106DRA Inner membrane protein YidI HVX74_00125 ENOG4105VG5 Membrane HVX74_00130 ENOG4105JP4 Inner membrane protein yidG HVX74_00135 ENOG4105J13 transcriptional regulator HVX74_00140 ENOG4105E5M Multidrug resistance protein D HVX74_00155 ENOG4105C7K acetolactate synthase HVX74_00160 ENOG4105M71 acetolactate synthase 1 regulatory subunit HVX74_00180 ENOG4108KX4 response regulator HVX74_00185 ENOG4105BZU Histidine kinase HVX74_00190 ENOG4105CXY transporter HVX74_00195 ENOG4105CXY transporter HVX74_00200 ENOG4108SAJ Protein of unknown function (DUF1198) HVX74_00210 ENOG4105VCP PTS System HVX74_00215 ENOG4105CS2 ec 3.2.1.21 HVX74_00220 ENOG4105CK1 PTS System HVX74_00230 ENOG4105ETE Transcriptional regulator (LacI family HVX74_00245 ENOG4105C7N Xanthine uracil vitamin C permease HVX74_00250 ENOG4108SAJ Protein of unknown function (DUF1198) HVX74_00260 ENOG4105T8A Uncharacterized protein YicS HVX74_00265 ENOG4105D01 (LipO)protein HVX74_00270 ENOG4108UZ3 Transporter HVX74_00275 ENOG4105S8Q sugar efflux transporter HVX74_00305 ENOG4105MAW Antitoxin component of a toxin-antitoxin (TA) module. Labile antitoxin that counteracts the effect of the CbtA (YeeV) toxin. It does not bind to the cognate toxin but instead binds to MreB and FtsZ (the toxin targets), enhancing their polymerization by forming higher-order bundles HVX74_00315 ENOG4108YGG dna repair protein HVX74_00320 ENOG4106549 Antirestriction protein HVX74_00325 ENOG4106H6R UPF0380 protein HVX74_00340 ENOG4108KZE transcriptional regulator HVX74_00345 ENOG4105TS0 gtp-binding protein HVX74_00450 ENOG4105D6U Sodium Glutamate Symporter HVX74_00465 ENOG4108ZHR arsR family transcriptional regulator HVX74_00515 ENOG4105T40 surface antigen msp4 family protein HVX74_00520 ENOG4108I6E Sulfatase HVX74_00530 ENOG4105DFP Integrase HVX74_00540 ENOG4105CT4 transporter HVX74_00545 ENOG4105CJQ hydrolase, family 31 HVX74_00550 ENOG4105JV1 AsmA family HVX74_00555 ENOG4105C2W permease HVX74_00560 ENOG4105D6U Sodium Glutamate Symporter HVX74_00570 ENOG4105CB5 ATP-dependent DNA helicase recG HVX74_00575 ENOG4105FE8 tRNA (Guanosine-2'-O-)-methyltransferase HVX74_00580 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) HVX74_00590 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) HVX74_00600 ENOG4105EN6 Membrane HVX74_00625 ENOG4105DSJ YicC domain protein HVX74_00645 ENOG4108Z1K This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) HVX74_00650 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase HVX74_00660 ENOG4105KDC 50s ribosomal protein l28 HVX74_00680 ENOG4105D8A 3-Deoxy-D-manno-octulosonic-acid transferase HVX74_00685 ENOG4105DKP glycosyl transferase, family 9 HVX74_00690 ENOG4107RJ7 Glycosyl transferase (Group 1 HVX74_00695 ENOG4107543 (lipo)polysaccharide HVX74_00700 ENOG4106AH0 Glycosyl Transferase HVX74_00705 ENOG4105X1N Glycosyl transferase family 8 HVX74_00715 ENOG4105X1N Glycosyl transferase family 8 HVX74_00720 ENOG4105K64 Glycosyl transferase, family 2 HVX74_00725 ENOG41068PG O-Antigen polymerase HVX74_00730 ENOG4105D16 lipopolysaccharide heptosyltransferase i HVX74_00735 ENOG4105XA0 heptosyltransferase ii HVX74_00745 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) HVX74_00755 ENOG4105K64 Glycosyl transferase, family 2 HVX74_00760 ENOG4105PXI polysaccharide deacetylase HVX74_00765 ENOG41063SB peptidase HVX74_00775 ENOG4107YZP Rhodanese domain protein HVX74_00780 ENOG4105VW4 glutaredoxin 3 HVX74_00795 ENOG4105D7W serine acetyltransferase HVX74_00800 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) HVX74_00810 ENOG41073TP transcriptional regulator HVX74_00815 ENOG4105DAA L-lactate HVX74_00825 ENOG4108WY4 inner membrane lipoprotein HVX74_00830 ENOG4108YYI Protein of unknown function (DUF2810) HVX74_00835 ENOG41060ND LF82 chromosome, complete sequence HVX74_00840 ENOG4105E61 Mannitol repressor protein HVX74_00850 ENOG4105CTS PTS system mannitol-specific HVX74_00855 ENOG4105FP6 Protein of unknown function (DUF3302) HVX74_00860 ENOG4105EFX secretion protein, HlyD family HVX74_00865 ENOG4108U78 Glutathione S-transferase HVX74_00875 ENOG4105EM7 Selenocysteine-specific translation elongation factor HVX74_00880 ENOG4105C0A alcohol dehydrogenase HVX74_00885 ENOG4105C26 Dehydrogenase HVX74_00890 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase HVX74_00895 ENOG41064BZ L-xylulose 5-phosphate 3-epimerase HVX74_00900 ENOG4105H6Q decarboxylase HVX74_00905 ENOG4105CMG Carbohydrate kinase HVX74_00910 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit HVX74_00915 ENOG4105CG6 trap dicarboxylate transporter dctm subunit HVX74_00920 ENOG4105XDZ Tripartite ATP-independent periplasmic transporter HVX74_00925 ENOG4108R66 Conserved Protein HVX74_00935 ENOG4105J4Q Transcriptional regulator HVX74_00940 ENOG4108XIB electron transport protein ysaA HVX74_00945 ENOG4105JKW Valine--pyruvate aminotransferase HVX74_00950 ENOG4107T9C Alpha amylase catalytic region HVX74_00955 ENOG4108UR8 BAX protein HVX74_00960 ENOG4105T16 Transcriptional regulator (AraC family) HVX74_00965 ENOG4108HWW ABC transporter HVX74_00975 ENOG4105DFW ABC transporter HVX74_00985 ENOG4105CMG Carbohydrate kinase HVX74_00990 ENOG410688U Inner membrane protein yiaB HVX74_00995 ENOG4108Z12 YiaAB two helix domain-containing protein HVX74_01000 ENOG4105MEV Acyl-transferase HVX74_01020 ENOG41060TC Hok gef cell toxic protein HVX74_01030 ENOG4105MVF Transcriptional regulator HVX74_01035 ENOG4106JH6 (LipO)protein HVX74_01045 ENOG4108ZG0 Ompa motb domain protein HVX74_01050 ENOG4107QY8 reductase HVX74_01055 ENOG4105HNP -acetyltransferase HVX74_01060 ENOG4108R3E Dna-3-methyladenine glycosylase i HVX74_01065 ENOG4105EAX Putative lipase HVX74_01070 ENOG4105FCD Major Facilitator HVX74_01075 ENOG4105DIJ Phosphoethanolamine transferase HVX74_01090 ENOG4105DEF Extracellular solute-binding protein, family 5 HVX74_01095 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HVX74_01100 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HVX74_01105 ENOG4105C3U ABC transporter HVX74_01110 ENOG4108JQ7 (ABC) transporter HVX74_01115 ENOG4105C44 Serine transporter HVX74_01135 ENOG4105D1V cellulose synthase operon protein YhjU HVX74_01140 ENOG4105WQA Cellulose biosynthesis protein BcsF HVX74_01145 ENOG4105U74 cellulose biosynthesis protein BcsE HVX74_01150 ENOG410661M cytoplasmic protein HVX74_01160 ENOG4107QZ7 Cellulose synthase catalytic subunit HVX74_01165 ENOG4107EEX Cellulose synthase regulator protein HVX74_01170 ENOG4105K2Z endo-1,4-d-glucanase (EC 3.2.1.4) HVX74_01175 ENOG4105EJG cellulose synthase HVX74_01180 ENOG4105BZU Histidine kinase HVX74_01190 ENOG4105CS0 peptidase HVX74_01195 ENOG4107SS6 2-dehydro-3-deoxygluconokinase HVX74_01200 ENOG4105CMB EAL domain-containing protein HVX74_01205 ENOG41066T0 asmA family HVX74_01210 ENOG4105CSH Transporter HVX74_01215 ENOG4107H3J ribonuclease HVX74_01220 ENOG4105CBN LysR family transcriptional regulator HVX74_01225 ENOG4106S2D Transcriptional regulator HVX74_01235 ENOG4105CA0 peroxidase HVX74_01240 ENOG4105CVK Glutamate decarboxylase HVX74_01245 ENOG4108NKV transcriptional regulator HVX74_01255 ENOG4105BZS acriflavin resistance protein HVX74_01260 ENOG4105C1P efflux transporter, rnd family, mfp subunit HVX74_01270 ENOG4106WJ0 Regulates the expression of several genes involved in acid resistance. Required for the expression of gadA and gadBC, among others, regardless of media or growth conditions. Binds directly to the 20 bp GAD box found in the control regions of both loci HVX74_01275 ENOG4108YK4 Acid-resistance membrane protein HVX74_01280 ENOG41060V2 Acid-resistance protein HVX74_01285 ENOG4105XXV Acid-resistance protein HVX74_01290 ENOG4105KT7 mgtC SapB transporter HVX74_01295 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) HVX74_01300 ENOG4105EHG Permease protein HVX74_01310 ENOG41090JE Utilization Protein HVX74_01315 ENOG4105D4P Coproporphyrinogen iii oxidase HVX74_01320 ENOG4107R4I Periplasmic binding protein HVX74_01325 ENOG4107ENK receptor HVX74_01330 ENOG4106QJH hemin transport protein HVX74_01340 ENOG4105Y4Z Outer Membrane Lipoprotein HVX74_01360 ENOG4105K89 arsenate reductase HVX74_01365 ENOG4107R5R arsenical pump membrane protein HVX74_01370 ENOG4105KBH arsR family transcriptional regulator HVX74_01385 ENOG4105DC8 reductase HVX74_01390 ENOG4105D6S protein involved in catabolism of external DNA HVX74_01395 ENOG4105DGW oligopeptidase A HVX74_01405 ENOG4105DUX Transporter HVX74_01420 ENOG4105CJ3 phosphate transporter HVX74_01425 ENOG4105CBX hi0933 family HVX74_01430 ENOG4107UNS conserved inner membrane protein HVX74_01435 ENOG4105D0S secretion protein (HlyD HVX74_01440 ENOG4105CJ1 ABC, transporter HVX74_01445 ENOG4105CMI transporter HVX74_01450 ENOG4105D2N Aldolase HVX74_01465 ENOG4105DT3 PTS system, galactitol-specific IIc component HVX74_01470 ENOG41090UW PTS System HVX74_01490 ENOG4105EFJ Part of the ABC transporter complex NikABCDE involved in nickel import. Responsible for energy coupling to the transport system (By similarity) HVX74_01495 ENOG4106665 Part of the ABC transporter complex NikABCDE involved in nickel import. Responsible for energy coupling to the transport system (By similarity) HVX74_01500 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HVX74_01505 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HVX74_01510 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein HVX74_01515 ENOG4107YAK holo-(acyl carrier protein) synthase 2 HVX74_01520 ENOG4105DSF transport protein HVX74_01525 ENOG4105F9N Major Facilitator Superfamily HVX74_01530 ENOG4108W1V Lipoprotein HVX74_01535 ENOG4105EX9 Membrane HVX74_01550 ENOG4107FS9 Membrane HVX74_01560 ENOG4105MG3 Membrane HVX74_01565 ENOG4106H78 methyltransferase HVX74_01570 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) HVX74_01575 ENOG4105CAK Cell division ATP-binding protein ftsE HVX74_01580 ENOG4105CRP Part of the ABC transporter FtsEX involved in HVX74_01585 ENOG4105DEK Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HVX74_01590 ENOG4105CP9 extracellular ligand-binding receptor HVX74_01595 ENOG4105U59 -acetyltransferase HVX74_01600 ENOG4105CP9 extracellular ligand-binding receptor HVX74_01605 ENOG4105C32 Amino acid ABC transporter (Permease) HVX74_01610 ENOG4105CF8 branched-chain amino acid ABC transporter, permease HVX74_01615 ENOG4105C0Z ABC transporter HVX74_01620 ENOG4108IV0 ABC, transporter HVX74_01625 ENOG4105BZ7 extracellular solute-binding protein family 1 HVX74_01630 ENOG4105E4X binding-protein-dependent transport systems inner membrane Component HVX74_01645 ENOG4107T6V glycerophosphoryl diester phosphodiesterase HVX74_01650 ENOG4105WC8 Conserved Protein HVX74_01655 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) HVX74_01660 ENOG4106FA4 HVX74_01665 ENOG4105WCN acetyltransferase HVX74_01670 ENOG4105D9R oxidoreductase HVX74_01675 ENOG4105C2I pirin domain protein HVX74_01680 ENOG4105DIQ Transcriptional regulator HVX74_01685 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family HVX74_01690 ENOG4105C6Z Gluconate HVX74_01695 ENOG41076UM multiple antibiotic resistance (MarC)-related protein HVX74_01700 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) HVX74_01705 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) HVX74_01725 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) HVX74_01735 ENOG4108NAE Fimbrial chaperone protein HVX74_01740 ENOG4105CW0 outer membrane usher protein HVX74_01745 ENOG4108WDE Fimbrial protein HVX74_01755 ENOG4106PH7 chaperone HVX74_01780 ENOG4105C6V Glycerol-3-phosphate dehydrogenase HVX74_01795 ENOG4105E98 transcriptional regulator DeoR family HVX74_01800 ENOG4105CYB regulatoR HVX74_01805 ENOG4105E0Y RtcB Protein HVX74_01820 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) HVX74_01825 ENOG4107RTM 4-alpha-glucanotransferase (EC 2.4.1.25) HVX74_01830 ENOG4105C6Z Gluconate HVX74_01840 ENOG4105MJ2 Competence protein HVX74_01860 ENOG4105CE1 Ferrous iron transport protein b HVX74_01865 ENOG4105XFK Ferrous iron transport protein A HVX74_01870 ENOG4105BZM domain protein HVX74_01875 ENOG4108RRZ Transcription elongation factor GreB HVX74_01885 ENOG4105E0F Histidine kinase HVX74_01895 ENOG4108MAJ Membrane HVX74_01905 ENOG4105VEJ Heat shock protein HVX74_01910 ENOG4107Y3D HAD-superfamily hydrolase subfamily IA variant 3 HVX74_01915 ENOG4105DQY intracellular growth attenuator HVX74_01920 ENOG4107RK2 ADP-ribose diphosphatase NudE HVX74_01925 ENOG4108JQC penicillin-binding protein 1A HVX74_01930 ENOG4108U1Q Pilus assembly protein HVX74_01935 ENOG41065NF Fimbrial assembly family protein HVX74_01940 ENOG4105XPX DNA utilization protein HofO HVX74_01945 ENOG4105ITY Required for the use of extracellular DNA as a nutrient HVX74_01950 ENOG4105E4G Type IV pilus HVX74_01965 ENOG4105EGB membrane protein DamX HVX74_01970 ENOG4105DFE Dna adenine methylase HVX74_01975 ENOG4105DJV ribulose-phosphate 3-epimerase HVX74_01980 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) HVX74_01985 ENOG4105C31 Tryptophanyl-tRNA synthetase HVX74_01990 ENOG4108M21 HVX74_01995 ENOG4105RMW regulation of transcription, DNA-dependent HVX74_02000 ENOG4108626 Racemase HVX74_02005 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) HVX74_02010 ENOG41080QX K07048 phosphotriesterase-related protein HVX74_02015 ENOG4105MUZ Protein of unknown function DUF2620 HVX74_02020 ENOG4106M0N transport system permease protein HVX74_02025 ENOG4106PKC pyridoxal phosphate binding HVX74_02030 ENOG4105FDP GntR family transcriptional regulator HVX74_02035 ENOG4108KPW sugar kinase HVX74_02040 ENOG4107Y0V Not clear, may be involved in an isomerization step HVX74_02045 ENOG4107R1S catalyzes the conversion of fructoselysine 6-phosphate to glucose 6-phosphate and lysine HVX74_02050 ENOG4107QHQ amino acid HVX74_02055 ENOG4105VYH HVX74_02065 ENOG4107V9H nitrite transporter HVX74_02070 ENOG4105WZK nitrite reductase NADPH small subunit HVX74_02075 ENOG4107QZF nitrite reductase NADPH large subunit HVX74_02085 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) HVX74_02095 ENOG4105MZU cell filamentation protein HVX74_02100 ENOG4105DDQ anthranilate synthase HVX74_02105 ENOG4105C8Y Acetylornithine aminotransferase HVX74_02110 ENOG410613R integral membrane protein, YccS YhfK family HVX74_02120 ENOG4108UKZ OsmC family HVX74_02125 ENOG4105CJE phosphoribulokinase (EC 2.7.1.19) HVX74_02135 ENOG4105DNZ Alpha Beta Hydrolase HVX74_02140 ENOG4105C5H ABC transporter HVX74_02155 ENOG4105VKU nucleicacid-binding protein HVX74_02160 ENOG4108YZY peptidylprolyl cis-trans isomerase HVX74_02170 ENOG4108V1T peptidylprolyl cis-trans isomerase HVX74_02175 ENOG4105WWK YheO domain protein HVX74_02185 ENOG4108ZKU Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions (By similarity) HVX74_02215 ENOG4105W53 bacterioferritin-associated ferredoxin HVX74_02220 ENOG4108UQY Iron-storage protein HVX74_02245 ENOG41080KG One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) HVX74_02290 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) HVX74_02335 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) HVX74_02340 ENOG41067V7 50S ribosomal protein L36 HVX74_02370 ENOG4105VTS DnaJ-like, subfamily C HVX74_02375 ENOG4105W1Y Transcriptional regulator HVX74_02380 ENOG4105VCN Rescues the ribosomes stalled at the 3' end of non-stop mRNAs. May induce hydrolysis of the ribosome-bound peptidyl-tRNA. This activity is crucial when the stalled ribosome can not be rescued by the SsrA(tmRNA)-SmpB quality control system HVX74_02390 ENOG4105C1A potassium transporter peripheral membrane HVX74_02410 ENOG4105C79 DNA protecting protein DprA HVX74_02420 ENOG4108WI1 Dna topoisomerase HVX74_02435 ENOG4105SG3 Protein of unknown function (DUF1488) HVX74_02440 ENOG4108Z0R Transferase HVX74_02480 ENOG4105CDA abc transporter atp-binding protein HVX74_02485 ENOG4105DRP amino acid AbC transporter HVX74_02490 ENOG4105EZ7 amino acid ABC transporter HVX74_02500 ENOG4105XCM membrane LIPOPROTEIN HVX74_02505 ENOG4105BZS acriflavin resistance protein HVX74_02510 ENOG4105C1P efflux transporter, rnd family, mfp subunit HVX74_02520 ENOG41061ME transport protein HVX74_02525 ENOG4105CEC DNA methylase N-4 N-6 HVX74_02535 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) HVX74_02545 ENOG4108IA2 Sodium pantothenate symporter HVX74_02550 ENOG4105RG0 Membrane HVX74_02555 ENOG4107UEK pfkb domain protein HVX74_02560 ENOG4105E98 transcriptional regulator DeoR family HVX74_02565 ENOG4105D2N Aldolase HVX74_02570 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator HVX74_02575 ENOG4105C2J ABC transporter HVX74_02580 ENOG4105CNN ABC, transporter HVX74_02585 ENOG4107UEK pfkb domain protein HVX74_02595 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase HVX74_02600 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein HVX74_02610 ENOG4105D3Z quinone oxidoreductase, yhdh yhfp family HVX74_02615 ENOG41062P1 Diguanylate cyclase phosphodiesterase HVX74_02625 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) HVX74_02630 ENOG4105VQ7 Rod shape-determining protein MreD HVX74_02640 ENOG4105C03 ribonuclease HVX74_02645 ENOG4105QD6 exported protein HVX74_02650 ENOG4105D1U peptidase U62 modulator of DNA gyrase HVX74_02655 ENOG4105CR8 Transcriptional regulator HVX74_02660 ENOG4105ZQC membrane protein AaeX HVX74_02675 ENOG4105UNR (Barnase) inhibitor HVX74_02680 ENOG4105RID UPF0379 protein yhcN HVX74_02695 ENOG4105C0H protease HVX74_02700 ENOG4105C0H protease HVX74_02705 ENOG4108W2Q Cytochrome d ubiquinol oxidase subunit III HVX74_02710 ENOG4105D6Z AFG1 family ATPase HVX74_02725 ENOG4107MKT Stringent starvation protein a HVX74_02730 ENOG4105KB2 stringent starvation protein b HVX74_02735 ENOG4105CEE C4-dicarboxylate transporter HVX74_02765 ENOG4108R66 Conserved Protein HVX74_02770 ENOG4105BZ8 glutamate synthase HVX74_02775 ENOG4105CBC glutamate synthase HVX74_02780 ENOG4105N5T Radical SAM Protein HVX74_02785 ENOG4105BZU Histidine kinase HVX74_02790 ENOG4108556 Isoprenoid biosynthesis protein with amidotransferase-like domain HVX74_02800 ENOG4108NIH transferase activity, transferring phosphorus-containing groups HVX74_02805 ENOG41080Z8 PHOSPHOCARRIER protein HVX74_02815 ENOG4107RM2 PTS IIA-like nitrogen-regulatory protein PtsN HVX74_02820 ENOG41080QH sigma 54 modulation protein ribosomal protein S30EA HVX74_02825 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HVX74_02830 ENOG4108IUZ ABC transporter HVX74_02835 ENOG4105WI0 lipopolysaccharide transport periplasmic protein lptA HVX74_02840 ENOG4108P1K Required for the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane (By similarity) HVX74_02850 ENOG4105C2X Arabinose 5-phosphate isomerase HVX74_02855 ENOG4105FEU K -dependent Na -Ca exchanger HVX74_02860 ENOG4105DHJ ABC, transporter HVX74_02865 ENOG4105CY3 ABC transporter, permease HVX74_02870 ENOG4107PE3 Mammalian cell entry related domain protein HVX74_02875 ENOG4105E3I toluene tolerance HVX74_02880 ENOG4105UE2 Part of the ABC transporter complex MlaFEDB that actively prevents phospholipid accumulation at the cell surface. Probably maintains lipid asymmetry in the outer membrane by retrograde trafficking of phospholipids from the outer membrane to the inner membrane HVX74_02885 ENOG4105VFK BolA family HVX74_02895 ENOG4105HVQ Regulatory factor of maltose metabolism HVX74_02900 ENOG4105EAH synthase HVX74_02915 ENOG4105QYV Membrane HVX74_02925 ENOG4106HRJ d-alanyl-d-alanine carboxypeptidase HVX74_02930 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) HVX74_02935 ENOG4105HBR Rna-binding protein HVX74_02945 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) HVX74_02950 ENOG4105EEI dihydropteroate synthase HVX74_02960 ENOG4105NTZ Preprotein translocase subunit SecG HVX74_02990 ENOG4105CHV Transcription elongation factor NusA HVX74_03030 ENOG4105C1J atp-dependent rna helicase HVX74_03035 ENOG4105CIC tryptophan-specific transport protein HVX74_03040 ENOG4105DEN Luciferase family HVX74_03060 ENOG4108YYD acetyltransferase HVX74_03075 ENOG4107R7Y intracellular protease Pfpi family HVX74_03080 ENOG4105K4T epimerase HVX74_03085 ENOG4107S21 permease HVX74_03090 ENOG4105W4M Transport-associated protein HVX74_03110 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) HVX74_03115 ENOG4105I74 Fimbrial protein HVX74_03120 ENOG4105CW0 outer membrane usher protein HVX74_03125 ENOG4108VCD Chaperone HVX74_03130 ENOG4105Q10 Fimbrial-like protein HVX74_03135 ENOG4106HBN Galactosamine-6-phosphate isomerase HVX74_03140 ENOG4105F3R pts system mannose fructose sorbose family iid HVX74_03145 ENOG4105ETZ PTS System HVX74_03150 ENOG4108UZY PTS System HVX74_03160 ENOG4105E70 isomerase HVX74_03165 ENOG4105CE4 GlcNAc 6-P deacetylase HVX74_03170 ENOG4108YTN IIa component HVX74_03175 ENOG4105F3R pts system mannose fructose sorbose family iid HVX74_03185 ENOG4108RG5 PTS system N-acetylgalactosamine-specific transporter subunit IIB HVX74_03195 ENOG4105E98 transcriptional regulator DeoR family HVX74_03200 ENOG4108R8Z these effects are overcome by concomitant expression of antitoxin SohA (PrlF). Massive overexpression is toxic. Unlike most other characterized TA systems degrades rRNA, and co-folding of the proteins is necessary in vitro for inhibition of the RNase activity. It is not known if it has any sequence-specificity. Acts as a transcription factor. The YhaV PrlF complex binds the prlF-yhaV operon, probably negatively regulating its expression HVX74_03205 ENOG4105ZEG Suppressor protein HVX74_03210 ENOG4105CTX dehydratase HVX74_03215 ENOG4105DJB Major Facilitator Superfamily HVX74_03225 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase HVX74_03230 ENOG4105BZW Glycerate kinase HVX74_03245 ENOG410811B TRANSCRIPTIONal HVX74_03250 ENOG4105C7B Threonine dehydratase HVX74_03265 ENOG4105C6N Formate acetyltransferase HVX74_03270 ENOG4105KME endoribonuclease L-psp HVX74_03275 ENOG4105EJQ L-serine dehydratase HVX74_03280 ENOG4105C44 Serine transporter HVX74_03290 ENOG4106D80 Uncharacterized protein YhaL HVX74_03295 ENOG4108CNN domain protein HVX74_03300 ENOG4105CWB LysR family transcriptional Regulator HVX74_03310 ENOG4105KAF membrAne HVX74_03315 ENOG4105CHF Glutathione S-transferase HVX74_03320 ENOG4108VBZ doxx family HVX74_03325 ENOG4105YJD HVX74_03330 ENOG41090KG Inner membrane protein YqjE HVX74_03335 ENOG4105NE1 Conserved Protein HVX74_03340 ENOG4105WAY exported protein HVX74_03345 ENOG4105IYR Modulates the activity of the EnvZ OmpR two-component regulatory system, probably by directly modulating EnvZ enzymatic activity and increasing stability of phosphorylated OmpR (By similarity) HVX74_03350 ENOG4106W5V Membrane HVX74_03355 ENOG4107YCY Transcriptional regulator HVX74_03360 ENOG4105DPW Major facilitator superfamily MFS_1 HVX74_03370 ENOG4105CTX dehydratase HVX74_03375 ENOG4105P66 Membrane HVX74_03380 ENOG4107QV7 Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system) (By similarity) HVX74_03385 ENOG4105DU1 integral membrane protein, terc HVX74_03390 ENOG4105EE0 oxidoreductase HVX74_03395 ENOG4108UB4 uncharacterized protein ygjQ HVX74_03400 ENOG4108VKG metal-dependent hydrolase HVX74_03415 ENOG4108Z3N Transcriptional regulator HVX74_03420 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HVX74_03425 ENOG4107WCA isomerase HVX74_03430 ENOG4107W6W Conserved Protein HVX74_03435 ENOG4105E5D amino acid HVX74_03440 ENOG4105FK9 beta-D-galactosidase beta subunit HVX74_03445 ENOG4105CNT hydrolase family 2 HVX74_03450 ENOG4105CQ4 Transcriptional regulator HVX74_03455 ENOG4108Y51 tRNA-binding protein HVX74_03465 ENOG4107RHT methyl-accepting chemotaxis sensory transducer with Pas Pac sensor HVX74_03470 ENOG4105NTW Transcriptional regulator HVX74_03475 ENOG4105Q26 Siderophore-interacting protein HVX74_03490 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HVX74_03495 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) HVX74_03505 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) HVX74_03515 ENOG4107GFK fumarate HVX74_03520 ENOG4106DSS Tartrate dehydratase subunit alpha HVX74_03525 ENOG4105EJC lysr family transcriptional regulator HVX74_03535 ENOG4107ZVW dihydroneopterin aldolase HVX74_03550 ENOG4106MWK domain protein HVX74_03555 ENOG4105I7R Adenylate cyclase HVX74_03575 ENOG4107S78 Band 7 protein HVX74_03580 ENOG4105PV3 Inner membrane protein yqiJ HVX74_03590 ENOG4105W0Z cytoplasmic protein HVX74_03600 ENOG4108MY7 Fimbrial HVX74_03605 ENOG4108TTM chaperone HVX74_03615 ENOG4105H8W Fimbrial protein HVX74_03630 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b HVX74_03635 ENOG4106032 Glutathionylspermidine synthase HVX74_03645 ENOG4105DFG type I secretion outer membrane protein HVX74_03650 ENOG41087AY ADP-Ribose pyrophosphatase HVX74_03655 ENOG4108SX3 cytoplasmic protein HVX74_03660 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) HVX74_03665 ENOG4105IPS esterase HVX74_03670 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HVX74_03690 ENOG4108RVA ribokinase HVX74_03710 ENOG4105CT4 transporter HVX74_03720 ENOG4105E0A ABC, transporter HVX74_03725 ENOG4105DQ5 transport system permease protein HVX74_03730 ENOG4105EHG Permease protein HVX74_03740 ENOG4106KNT transcriptional regulator HVX74_03745 ENOG4105VRH Antibiotic biosynthesis monooxygenase HVX74_03750 ENOG4105NF4 modulator of drug activity HVX74_03755 ENOG4105DHQ Histidine kinase HVX74_03760 ENOG4105XJC Two component transcriptional regulator (Winged helix family HVX74_03765 ENOG4105H4F exported protein HVX74_03770 ENOG4105F4I Transcriptional regulator HVX74_03775 ENOG4108J59 Extracellular solute-binding protein, family 5 HVX74_03780 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HVX74_03785 ENOG4107S7E 1-acyl-sn-glycerol-3-phosphate acyltransferase HVX74_03790 ENOG4107TZ2 Cell division protein that is required for growth during stress conditions. May be involved in protecting or stabilizing the divisomal assembly under conditions of stress (By similarity) HVX74_03795 ENOG4105CG6 trap dicarboxylate transporter dctm subunit HVX74_03805 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit HVX74_03810 ENOG4105DG4 malate L-lactate dehydrogenase HVX74_03815 ENOG4105CPQ Dehydrogenase HVX74_03820 ENOG4105DEI Mannitol dehydrogenase HVX74_03825 ENOG4107YCY Transcriptional regulator HVX74_03830 ENOG4105CCT upf0313 protein HVX74_03840 ENOG4105ZKC Conserved Protein HVX74_03845 ENOG4105CV8 reductase HVX74_03850 ENOG4108I6A alcohol dehydrogenase HVX74_03855 ENOG4105CF7 AraC family transcriptional regulator HVX74_03860 ENOG4108K81 inner membrane protein YghB HVX74_03865 ENOG4105C28 cystathionine HVX74_03870 ENOG4105CWK Biopolymer transport protein, ExbB HVX74_03875 ENOG4108ZZF transport protein (ExbD) HVX74_03880 ENOG4105CYX Short-chain dehydrogenase reductase Sdr HVX74_03890 ENOG4105CPC Aldo Keto reductase HVX74_03900 ENOG410900S Protein of unknown function (DUF2623) HVX74_03905 ENOG4105E3S small subunit HVX74_03910 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein HVX74_03915 ENOG4105CJ5 hydrogenase 2 b cytochrome subunit HVX74_03920 ENOG4105DPX Hydrogenase, large subunit HVX74_03925 ENOG4108USZ hydrogenase HVX74_03930 ENOG4108WGS hydrogenase 2-specific chaperone HVX74_03935 ENOG4105WMM Probably plays a role in a hydrogenase nickel cofactor insertion step (By similarity) HVX74_03940 ENOG41082MF Hydrogenase assembly chaperone hypC hupF HVX74_03945 ENOG4105CYM Glutathione S-transferase HVX74_03950 ENOG4106032 Glutathionylspermidine synthase HVX74_03955 ENOG4105CJ3 phosphate transporter HVX74_03960 ENOG4108GH0 ATP-binding protein yghT HVX74_03965 ENOG4108NDC ATP-binding protein yghS HVX74_03970 ENOG4106FPV ATP-binding protein YghR HVX74_03975 ENOG4108S55 polysaccharide biosynthesis protein HVX74_03985 ENOG4108UUE Transcriptional regulator HVX74_03990 ENOG4108M8S permease YjgP YjgQ family protein HVX74_04005 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) HVX74_04015 ENOG4107RCI amp-dependent synthetase and ligase HVX74_04025 ENOG4108KWP DNA-binding transcriptional regulator GlcC HVX74_04030 ENOG4105CQB FAD linked oxidase domain protein HVX74_04035 ENOG4105EU8 FAD linked oxidase domain protein HVX74_04040 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) HVX74_04045 ENOG4108ZJF Glcg protein HVX74_04050 ENOG4107QP3 malate synthase g HVX74_04055 ENOG4105DAA L-lactate HVX74_04060 ENOG4105F88 accessory colonization factor AcfD HVX74_04065 ENOG4105EHH Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue (By similarity) HVX74_04070 ENOG410765S (LipO)protein HVX74_04085 ENOG4107QHF type ii secretion system protein e HVX74_04090 ENOG4105D7Q type ii secretion system HVX74_04095 ENOG4108VAU general secretion pathway protein G HVX74_04105 ENOG4105X5Z General secretion pathway protein I HVX74_04125 ENOG4105U1E general secretion pathway protein M HVX74_04135 ENOG4108UQV Membrane HVX74_04140 ENOG4105CXN decarboxylase HVX74_04145 ENOG4105EAA nucleoside HVX74_04160 ENOG4105CEN a g-specific adenine glycosylase HVX74_04170 ENOG41090ED Protein with unknown function (DUF469) HVX74_04175 ENOG4105K33 Periplasmic Protein HVX74_04180 ENOG4105HDK L-asparaginase HVX74_04185 ENOG4106MH3 alpha helix chain HVX74_04190 ENOG4105CG6 trap dicarboxylate transporter dctm subunit HVX74_04195 ENOG41069H7 transport system small permease component HVX74_04200 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit HVX74_04205 ENOG4105CSA Coproporphyrinogen iii oxidase HVX74_04210 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) HVX74_04220 ENOG4108VIA integral membrane protein HVX74_04225 ENOG4105DFA alanine racemase domain protein HVX74_04230 ENOG4105CZX twitching motility protein HVX74_04245 ENOG4105D7Z glutathione synthase HVX74_04250 ENOG4105QF0 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) HVX74_04255 ENOG4105RWS endonuclease I HVX74_04265 ENOG4107QNK )-transporter HVX74_04285 ENOG4105DP5 Catalyzes the biosynthesis of agmatine from arginine (By similarity) HVX74_04300 ENOG4108K0D peptidase, M48 HVX74_04305 ENOG4105CV1 Transketolase (EC 2.2.1.1) HVX74_04310 ENOG4105EPW hflc protein HVX74_04315 ENOG4108X7Y Mannitol-specific cryptic phosphotransferase enzyme iia HVX74_04320 ENOG4105CTS PTS system mannitol-specific HVX74_04325 ENOG4105DXH Alcohol dehydrogenase zinc-binding domain protein HVX74_04330 ENOG4108Q8A Fructose-1,6-bisphosphatase HVX74_04335 ENOG4108R4K DNA-binding, transcriptional regulator HVX74_04340 ENOG4107Z1W Fructose transport system kinase HVX74_04355 ENOG4105D2N Aldolase HVX74_04360 ENOG4105D64 Mechanosensitive ion channel HVX74_04365 ENOG4108ZUB Lysine exporter protein (Lyse ygga) HVX74_04370 ENOG4105MPN Membrane HVX74_04375 ENOG4105DEQ transcriptional regulator HVX74_04380 ENOG4105CYC Transferase HVX74_04385 ENOG4108M7F enoyl-CoA hydratase isomerase HVX74_04390 ENOG4105DJT lAO AO transport system ATPase HVX74_04395 ENOG4105D5P Methylmalonyl-coA mutase HVX74_04410 ENOG4108JQ1 Dehydrogenase HVX74_04420 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase HVX74_04440 ENOG4107RAQ aminopeptidase HVX74_04445 ENOG4105D0A hydroxylase HVX74_04450 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family HVX74_04475 ENOG4105CS2 ec 3.2.1.21 HVX74_04485 ENOG4108UT2 hemolysin iii HVX74_04495 ENOG4105Y75 tpr repeat protein HVX74_04500 ENOG4108YDB Toxic component of a toxin-antitoxin (TA) module. Overexpression leads to growth arrest after 5 hours, with initial elongation of cells, followed by swelling. The toxic effects are abrogated by coexpression with antitoxin CptB. Interacts with cytoskeletal proteins FtsZ and MreB HVX74_04505 ENOG41071R3 Low-potential electron donor to a number of redox enzymes (By similarity) HVX74_04510 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HVX74_04515 ENOG4105T95 Thiol disulfide interChange protein HVX74_04520 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) HVX74_04530 ENOG4105CRK lysyL-tRNA synthetase HVX74_04535 ENOG4108ZEY Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) HVX74_04550 ENOG4105C2W permease HVX74_04555 ENOG4105BZ8 glutamate synthase HVX74_04560 ENOG4108R8B oxidoreductase Fe-S subunit HVX74_04565 ENOG4105C7N Xanthine uracil vitamin C permease HVX74_04570 ENOG4107QUY Guanine deaminase HVX74_04575 ENOG4105C2W permease HVX74_04580 ENOG4105C7W Xanthine dehydrogenase HVX74_04585 ENOG410873Y FAD binding domain in molybdopterin dehydrogenase HVX74_04590 ENOG4107UUR Chlorohydrolase aminohydrolase HVX74_04595 ENOG4105BZ8 glutamate synthase HVX74_04600 ENOG4105MFX 4-diphosphocytidyl-2c-methyl-d-erythritol synthase HVX74_04605 ENOG4105MJ6 selenium-dependent hydroxylase accessory protein YqeC HVX74_04610 ENOG4107P0T Selenium-dependent molybdenum hydroxylase system protein, YqeB family HVX74_04615 ENOG4105C5B carbamate kinase HVX74_04625 ENOG4107S4Y M20 DapE family protein YgeY HVX74_04630 ENOG4107RCH Diaminopropionate ammonia-lyase HVX74_04635 ENOG4105IW6 Carbamoyltransferase HVX74_04640 ENOG4108JUB Transcriptional regulator HVX74_04645 ENOG4108UTP (2Fe-2S)-binding domain protein HVX74_04650 ENOG4108HR6 Dehydrogenase HVX74_04655 ENOG4105C7W Xanthine dehydrogenase HVX74_04660 ENOG4108K5P (LipO)protein HVX74_04670 ENOG4108MHD transport protein HVX74_04675 ENOG4105CHU acetyl-coa acetyltransferase HVX74_04685 ENOG4105CHR reductase HVX74_04690 ENOG4107QNK )-transporter HVX74_04700 ENOG4105RQF LysR family Transcriptional regulator HVX74_04710 ENOG41060NJ transcriptional regulator HVX74_04730 ENOG4105CPC Aldo Keto reductase HVX74_04735 ENOG4105SUV lipoprotein YgdR HVX74_04740 ENOG4105EE5 Membrane protein terC HVX74_04755 ENOG4108HRM phosphoenolpyruvate--protein phosphotransferase HVX74_04770 ENOG4105IPU prepilin peptidase dependent protein A HVX74_04775 ENOG4105JCS prepilin peptidase dependent protein HVX74_04780 ENOG4105SEN Protein of unknown function (DUF2509) HVX74_04785 ENOG4105RVB Prepilin peptidase dependent protein c HVX74_04790 ENOG4105DSY exodeoxyribonuclease V, gamma HVX74_04795 ENOG4107QXK peptidase HVX74_04800 ENOG4107QKA exodeoxyribonuclease V beta HVX74_04805 ENOG4107QYX exodeoxyribonuclease v alpha HVX74_04810 ENOG4108EKC n-acetylglutamate synthase HVX74_04815 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase HVX74_04835 ENOG4105CA3 membrane-bound lytic murein transglycosylase HVX74_04840 ENOG4105CUZ uba thif-type nad fad binding protein HVX74_04845 ENOG4105P9C Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity) HVX74_04850 ENOG4105C9B Cysteine desulfurase HVX74_04855 ENOG4105M5B (LipO)protein HVX74_04860 ENOG4105ETT transcriptional Regulator, LysR family HVX74_04865 ENOG4105M08 Membrane HVX74_04875 ENOG4107EDW L-fucose operon activator HVX74_04885 ENOG4105CMG Carbohydrate kinase HVX74_04895 ENOG4105EDR glucose galactose transporter HVX74_04900 ENOG4107W7X Aldolase HVX74_04905 ENOG4105C0A alcohol dehydrogenase HVX74_04915 ENOG4105EJQ L-serine dehydratase HVX74_04920 ENOG4105C44 Serine transporter HVX74_04925 ENOG4105EWT decarboxylase family HVX74_04940 ENOG4105WP7 tRNA pseudouridine synthase C HVX74_04945 ENOG4105DR9 pseudouridine synthase HVX74_04950 ENOG4105QDK Flavodoxin HVX74_04955 ENOG4105DJB Major Facilitator Superfamily HVX74_04960 ENOG4105EQX glucarate dehydratase HVX74_04965 ENOG4105EQX glucarate dehydratase HVX74_04970 ENOG4105BZU Histidine kinase HVX74_04980 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) HVX74_04985 ENOG4106A2Z transcriptional regulator antitoxin, MazE HVX74_04990 ENOG4105MZG transcriptional modulator of maze toxin, mazf HVX74_04995 ENOG4105DXN mazG family HVX74_05010 ENOG4105HA9 of methanol dehydrogenase type HVX74_05020 ENOG4105HA9 of methanol dehydrogenase type HVX74_05030 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) HVX74_05035 ENOG4108CWB sugar kinase ygcE HVX74_05040 ENOG4108ITV Inner membrane protein yqcE HVX74_05045 ENOG4105CHR reductase HVX74_05050 ENOG4107R3A FAD linked oxidase domain protein HVX74_05055 ENOG4105C54 Major Facilitator superfamily HVX74_05060 ENOG4106IKH Electron transfer flavoprotein HVX74_05065 ENOG4105YBM electron transfer flavoprotein subunit ygcQ HVX74_05070 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator HVX74_05075 ENOG4105WQV ferredoxin-like protein HVX74_05080 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase HVX74_05085 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase HVX74_05105 ENOG4107635 Hok Gef family protein HVX74_05110 ENOG4105DTT CRISPR-associated helicase, cas3 HVX74_05115 ENOG4105CYR Crispr-associated protein, cse1 family HVX74_05125 ENOG41060M0 Crispr-associated protein, cse4 family HVX74_05130 ENOG4108VWQ crispr-associated protein HVX74_05140 ENOG4105TZK CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. May be involved in the integration of spacer DNA into the CRISPR cassette (By similarity) HVX74_05145 ENOG4105PWE CRISPR-associated protein cas2 HVX74_05150 ENOG4108MXK alkaline phosphatase isozyme conversion HVX74_05170 ENOG4105N0Z inner membrane protein ygbE HVX74_05190 ENOG4106NZV Responsible for synthesis of pseudouridine from uracil- 13 in transfer RNAs (By similarity) HVX74_05205 ENOG4108K5P (LipO)protein HVX74_05210 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HVX74_05220 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase HVX74_05225 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) HVX74_05230 ENOG4105KZM cytoplasmic protein HVX74_05235 ENOG4105C6Z Gluconate HVX74_05240 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) HVX74_05250 ENOG4105G63 Type III effector Hrp-dependent HVX74_05260 ENOG4105MVE transcriptional regulator HVX74_05265 ENOG4105MEW serine threonine protein phosphatase HVX74_05270 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) HVX74_05275 ENOG4105VXR cytoplasmic protein HVX74_05285 ENOG4108JUA Transcriptional regulator HVX74_05290 ENOG4105C45 hydrogenase expression formation protein (HypE) HVX74_05295 ENOG4105CQS hydrogenase expression formation protein HypD HVX74_05300 ENOG41083WG hydrogenase assembly chaperone HVX74_05305 ENOG4107RSS Hydrogenase accessory protein HypB HVX74_05310 ENOG410816D Probably plays a role in a hydrogenase nickel cofactor insertion step (By similarity) HVX74_05315 ENOG4108VRC Formate hydrogenlyase regulatory protein hycA HVX74_05320 ENOG4108MFN small subunit of hydrogenase-3, iron-sulfur protein (part of formate hydrogenlyase (FHL) complex) HVX74_05325 ENOG4107R30 NADH dehydrogenase HVX74_05330 ENOG4107TDF Formate hydrogenlyase subunit 4 HVX74_05335 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HVX74_05340 ENOG4108RG7 formate hydrogenlyase complex iron-sulfur subunit HVX74_05345 ENOG4105C47 NADH ubiquinone oxidoreductase 20 kda subunit HVX74_05350 ENOG4105I6X formate hydrogenlyase maturation HVX74_05355 ENOG4108MG9 hydrogenase 3 maturation protease HVX74_05365 ENOG4108Z3N Transcriptional regulator HVX74_05370 ENOG4105CS2 ec 3.2.1.21 HVX74_05375 ENOG4105C5Y PTS System HVX74_05380 ENOG4105DDV Transcriptional regulator (LacI family HVX74_05385 ENOG4108RC0 Electron transport protein HVX74_05390 ENOG4105C8H hydrogenase maturation protein Hypf HVX74_05415 ENOG410804X Transcriptional regulator HVX74_05420 ENOG4105J92 DNA-binding transcriptional activator GutM HVX74_05425 ENOG4107QMF Sorbitol-6-phosphate dehydrogenase HVX74_05430 ENOG4105VI0 Pts system, glucitol sorbitol-specific HVX74_05435 ENOG4105DZY Pts system, glucitol sorbitol-specific HVX74_05440 ENOG410787A Pts system, glucitol sorbitol-specific HVX74_05445 ENOG4105CVE Lytic murein transglycosylase HVX74_05450 ENOG4107TH8 cina domain protein HVX74_05470 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) HVX74_05500 ENOG4107VXZ Hydrolase HVX74_05505 ENOG4105W39 Membrane HVX74_05530 ENOG4105C0R drug resistance transporter emrb qaca subfamily HVX74_05535 ENOG4105CW7 secretion protein, HlyD family HVX74_05540 ENOG4105NTK Transcriptional repressor Mpra HVX74_05545 ENOG4105ZED uncharacterized protein ygaH HVX74_05550 ENOG4108UMN azlc family HVX74_05560 ENOG4105GIJ Glycine betaine HVX74_05565 ENOG4108HQS Glycine betaine HVX74_05570 ENOG4108IJ7 Glycine betaine HVX74_05575 ENOG4107R25 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HVX74_05580 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HVX74_05590 ENOG4105WAZ (Glutaredoxin-like protein) NrdH HVX74_05595 ENOG4108ZQZ Bacterial protein of unknown function (DUF883) HVX74_05600 ENOG4108WMJ Protein of unknown function (DUF2002) HVX74_05605 ENOG4108RNS Exports L-alanine (By similarity) HVX74_05610 ENOG4108X73 DNA- binding protein HVX74_05615 ENOG4108V62 Rhodanese domain protein HVX74_05620 ENOG41080HT Transcriptional regulator, arsr family HVX74_05625 ENOG4105VPI YqaE family transport protein HVX74_05630 ENOG4109066 lysm domain bon superfamily protein HVX74_05635 ENOG4108PVQ transcriptional regulator HVX74_05640 ENOG4105C85 amino acid HVX74_05645 ENOG4108JPW Aminotransferase HVX74_05650 ENOG4105C26 Dehydrogenase HVX74_05655 ENOG4105D5U fad dependent oxidoreductase HVX74_05670 ENOG4107UNZ domain protein HVX74_05700 ENOG4105MAW Antitoxin component of a toxin-antitoxin (TA) module. Labile antitoxin that counteracts the effect of the CbtA (YeeV) toxin. It does not bind to the cognate toxin but instead binds to MreB and FtsZ (the toxin targets), enhancing their polymerization by forming higher-order bundles HVX74_05705 ENOG4105ZS6 Protein of unknown function (DUF987) HVX74_05710 ENOG4108XS9 dna repair protein HVX74_05715 ENOG4106549 Antirestriction protein HVX74_05720 ENOG4106H6R UPF0380 protein HVX74_05735 ENOG4108MXD gtp-binding protein HVX74_05760 ENOG4108P8R HVX74_05765 ENOG410679B prophage CP4-57 regulatory protein alpA HVX74_05775 ENOG4105DFP Integrase HVX74_05790 ENOG4108Z1B Cyclase dehydrase HVX74_05800 ENOG4105YRI Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) HVX74_05805 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) HVX74_05820 ENOG4108JU6 CBS domain protein HVX74_05825 ENOG4106KVJ cytochrome C assembly protein HVX74_05830 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY HVX74_05855 ENOG41090EK ompa motb domain protein HVX74_05860 ENOG4108KHX Diguanylate cyclase HVX74_05865 ENOG4108WS1 HVX74_05870 ENOG4105QP9 Protein of unknown function (DUF2799) HVX74_05875 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) HVX74_05880 ENOG4105EHE chorismate mutase- prephenate dehydrogenase HVX74_05885 ENOG4105CQC Prephenate dehydratase HVX74_05895 ENOG4108WPH sigma 54 modulation protein ribosomal protein S30EA HVX74_05905 ENOG4106SNF Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane HVX74_05910 ENOG4105C34 Pseudouridine synthase HVX74_05915 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase HVX74_05920 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit HVX74_05945 ENOG4105CSH Transporter HVX74_05950 ENOG4105T42 (LipO)protein HVX74_05955 ENOG4105JIM Phosphatidylserine synthase HVX74_05960 ENOG4105CD5 CoA-binding domain protein HVX74_05965 ENOG4106IUH DTW domain containing protein HVX74_05970 ENOG4105K63 Thioredoxin HVX74_05975 ENOG4105EIB trna rrna methyltransferase HVX74_05995 ENOG41090KR LysR family transcriptional Regulator HVX74_06000 ENOG4105C1J atp-dependent rna helicase HVX74_06010 ENOG4108IYU L-aspartate oxidase HVX74_06020 ENOG4105EMN RNA polymerase sigma factor HVX74_06025 ENOG41069PW sigma-e factor negative regulatory protein HVX74_06030 ENOG4105VQK sigma E regulatory protein, MucB RseB HVX74_06035 ENOG4105WMJ Positive regulator of sigma E, RseC MucC HVX74_06045 ENOG4105C3F Signal peptidase i HVX74_06065 ENOG4105CSZ Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity) HVX74_06080 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding HVX74_06085 ENOG4106G6Q Transcriptional regulator HVX74_06090 ENOG4105HYY HAD superfamily (Subfamily IF) hydrolase, YfhB HVX74_06095 ENOG4108Z6B deaminase HVX74_06105 ENOG4108ETH Formylglycinamide ribotide synthetase HVX74_06110 ENOG4107WP9 Histidine kinase HVX74_06115 ENOG4108SKK alpha helix protein HVX74_06120 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family HVX74_06130 ENOG4108EGH Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) HVX74_06140 ENOG4108NZE NAGC-like transcriptional regulator HVX74_06145 ENOG4107HQ7 repeat protein HVX74_06150 ENOG4105FCA ABC transporter periplasmic-binding protein YphF HVX74_06155 ENOG4108F37 ATP-binding component of a transport system HVX74_06160 ENOG4105CNN ABC, transporter HVX74_06165 ENOG4105CPQ Dehydrogenase HVX74_06170 ENOG4108ZKT aldose 1-epimerase HVX74_06175 ENOG4108SB3 DoxX Family HVX74_06200 ENOG4105FUY alpha subunit HVX74_06205 ENOG4108W5M transcriptional regulator HVX74_06210 ENOG4105D8G Major Facilitator superfamily HVX74_06215 ENOG4108MN2 Stationary phase inducible protein CsiE HVX74_06220 ENOG4107XM9 (LipO)protein HVX74_06225 ENOG4105ECY inositol monophosphatase HVX74_06245 ENOG4107XTC May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins HVX74_06265 ENOG4108ZIT Ferredoxin, 2FE-2S HVX74_06270 ENOG4105WVQ Fe-S assembly protein IscX HVX74_06280 ENOG4105YYA enhanced serine sensitivity protein SseB HVX74_06290 ENOG4105KHC sulfurtransferase HVX74_06295 ENOG4105DN3 alpha-2-macroglobulin domain protein HVX74_06300 ENOG4108JQB penicillin-binding protein 1C HVX74_06330 ENOG4105N21 Membrane HVX74_06345 ENOG4105VPD cellular component movement HVX74_06370 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) HVX74_06410 ENOG41076J9 exonuclease VIII HVX74_06505 ENOG4108TFU terminase (Small subunit) HVX74_06635 ENOG4105NVB glycoside hydrolase, family 19 HVX74_06645 ENOG41066DY Membrane HVX74_06650 ENOG4108ZMA Outer membrane lipoprotein HVX74_06655 ENOG41062G3 Protein of unknown function (DUF2633) HVX74_06665 ENOG4105BZU Histidine kinase HVX74_06670 ENOG4105C9X ppx gppa phosphatase HVX74_06675 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) HVX74_06680 ENOG4108V3E phosphoribosylglycinamide formyltransferase HVX74_06695 ENOG4105C2W permease HVX74_06700 ENOG4108KZ1 Mediates the interaction of DNA replication inititator protein DnaA with DNA polymerase subunit beta sliding clamp (dnaN). Stimulates hydrolysis of ATP-DnaA to ADP-DnaA, rendering DnaA inactive for reinititation, a process called regulatory inhibition of DnaA or RIDA (By similarity) HVX74_06705 ENOG4105K89 arsenate reductase HVX74_06710 ENOG4105ERG peptidase m48, ste24p HVX74_06715 ENOG4105C02 permease HVX74_06720 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen HVX74_06725 ENOG4105RH4 Glycine cleavage system transcriptional repressor HVX74_06735 ENOG4107EG0 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) HVX74_06745 ENOG4105CGZ zinc metallopeptidase HVX74_06755 ENOG4106KED esterase YpfH HVX74_06770 ENOG4105KUZ arsenate reductase HVX74_06780 ENOG4105BZS acriflavin resistance protein HVX74_06785 ENOG4105BZU Histidine kinase HVX74_06790 ENOG4105BZ8 glutamate synthase HVX74_06800 ENOG4108PVD exported protein HVX74_06805 ENOG4105CV1 Transketolase (EC 2.2.1.1) HVX74_06810 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) HVX74_06815 ENOG4105C6K Malic enzyme HVX74_06820 ENOG4108VJN May be involved in the formation of a specific microcompartment in the cell in which the metabolism of potentially toxic by-products takes place HVX74_06825 ENOG4106S4J ethanolamine utilization protein EutP HVX74_06830 ENOG4105NDK ethanolamine utilization protein HVX74_06835 ENOG4108PFF ethanolamine utilization cobalamin adenosyltransferase HVX74_06840 ENOG4107WUY phosphate acetyltransferase HVX74_06845 ENOG4105KNY Microcompartments protein HVX74_06850 ENOG4105WVM ethanolamine utilization protein EutN carboxysome structural protein Ccml HVX74_06855 ENOG4108EKI Dehydrogenase HVX74_06860 ENOG4107RWI ethanolamine utilization protein eutJ HVX74_06865 ENOG4105C0A alcohol dehydrogenase HVX74_06870 ENOG4105ENY Ethanolamine utilization protein eutH HVX74_06875 ENOG4105DYY Reactivating factor for ethanolamine ammonia lyase HVX74_06880 ENOG4105CPD ethanolamine ammonia-lyase HVX74_06890 ENOG4106D67 ethanolamine utilization protein HVX74_06895 ENOG4108X49 Ethanolamine utilization protein EutK HVX74_06900 ENOG4108K3Z AraC family transcriptional regulator HVX74_06910 ENOG4108KNB n-acetylmuramoyl-l-alanine amidase HVX74_06920 ENOG4105QZU Inner membrane protein YfeZ HVX74_06925 ENOG4105E7K (LipO)protein HVX74_06930 ENOG4105EZR dyp-type peroxidase family protein HVX74_06935 ENOG4105C5Y PTS System HVX74_06950 ENOG4105I7Z Short-chain dehydrogenase reductase Sdr HVX74_06955 ENOG4108J2H Sulfate ABC transporter periplasmic sulfate-binding protein HVX74_06960 ENOG4108I5D sulfate abc transporter HVX74_06965 ENOG4105ECW sulfate abc transporter HVX74_06970 ENOG4108IJ6 ABC transporter HVX74_06975 ENOG4105C6T cysteine synthase HVX74_06980 ENOG4105WEC Molybdate metabolism regulator HVX74_06985 ENOG4105M0Y HVX74_06995 ENOG4105C5Y PTS System HVX74_07000 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) HVX74_07010 ENOG4105C6T cysteine synthase HVX74_07030 ENOG4105VRT cytoplasmic protein HVX74_07035 ENOG4105DHU Bile acid HVX74_07040 ENOG4108M0I Transcriptional regulator HVX74_07045 ENOG4108NFH Sugar hydrolase HVX74_07050 ENOG4107U5R The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity) HVX74_07055 ENOG4105EAA nucleoside HVX74_07065 ENOG4105CN8 Transcriptional regulator HVX74_07090 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) HVX74_07095 ENOG4105GXM Putative transcription regulator (DUF1323) HVX74_07100 ENOG4105HZG regulatoR HVX74_07115 ENOG4108KMM Diguanylate cyclase HVX74_07120 ENOG4105D9N nucleoside HVX74_07130 ENOG4109076 Conserved Protein HVX74_07135 ENOG4105VCT ion-transport protein YfeO HVX74_07145 ENOG4105R6B The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane (By similarity) HVX74_07150 ENOG410863U PTS System HVX74_07155 ENOG4105DC7 peptidase M24 HVX74_07160 ENOG4105CN9 Peptidase m42 family protein HVX74_07165 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) HVX74_07170 ENOG4108CIP transcriptional regulator HVX74_07175 ENOG4105DY9 regulatoR HVX74_07180 ENOG4108HRK Histidine kinase HVX74_07185 ENOG4105CHM Aminotransferase HVX74_07195 ENOG4105D1S lipid A biosynthesis HVX74_07200 ENOG4105W9M Membrane HVX74_07210 ENOG4108V08 YfdX protein HVX74_07220 ENOG4105CFN oxalyl-CoA decarboxylase HVX74_07225 ENOG4108N2Y auxin Efflux HVX74_07230 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F HVX74_07235 ENOG4105BZU Histidine kinase HVX74_07240 ENOG4108WQH regulatoR HVX74_07245 ENOG4105CW7 secretion protein, HlyD family HVX74_07250 ENOG4105C0R drug resistance transporter emrb qaca subfamily HVX74_07265 ENOG4106NDP Transcriptional regulator HVX74_07270 ENOG4108HKT sucrose-6-phosphate hydrolase HVX74_07275 ENOG4105D7K pfkb domain protein HVX74_07280 ENOG4105U0F oligosaccharide H symporter, major facilitator superfamily (MFS) HVX74_07295 ENOG4105S64 Formate nitrite transporter HVX74_07300 ENOG410903C (LipO)protein HVX74_07305 ENOG4105CKF membrane protein involved in aromatic hydrocarbon degradation HVX74_07310 ENOG4105KZW UPF0381 protein HVX74_07320 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase HVX74_07325 ENOG4108BY2 phosphohistidine phosphatase HVX74_07355 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase HVX74_07360 ENOG4105HPZ Involved in the removal of murein from the sacculus. May also facilitate integration of nascent murein strands into the sacculus by cleaving the peptide bonds between neighboring strands in mature murein (By similarity) HVX74_07365 ENOG4105EJ9 Membrane HVX74_07370 ENOG4108BPE -transporting atpase HVX74_07375 ENOG4105MH2 YfcL protein HVX74_07385 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) HVX74_07390 ENOG4105F9N Major Facilitator Superfamily HVX74_07395 ENOG4106WZ1 flagella biosynthesis regulator HVX74_07405 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) HVX74_07415 ENOG4105DQR SNARE associated Golgi HVX74_07425 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase HVX74_07430 ENOG4108S3P Sporulation domain protein HVX74_07435 ENOG4105E96 Colicin v production protein HVX74_07440 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase HVX74_07445 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase HVX74_07450 ENOG4105E89 ABC transporter HVX74_07455 ENOG4105E89 ABC transporter HVX74_07460 ENOG4105DSP amino acid AbC transporter HVX74_07465 ENOG4106YG3 ABC transporter HVX74_07470 ENOG4108JEH abc transporter atp-binding protein HVX74_07475 ENOG4105DNE Transposase HVX74_07480 ENOG4105ECP epimerase HVX74_07485 ENOG4105KKP D-erythro-7,8-dihydroneopterin triphosphate 2'-epimerase HVX74_07490 ENOG4105CYM Glutathione S-transferase HVX74_07495 ENOG4108SHQ Glutathione S-transferase HVX74_07500 ENOG4108RE9 Phosphodiesterase HVX74_07505 ENOG4105PTV Nudix Hydrolase HVX74_07510 ENOG4105CSX c4-dicarboxylate anaerobic carrier HVX74_07515 ENOG4105C6K Malic enzyme HVX74_07520 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) HVX74_07530 ENOG4105XWI UPF0304 protein HVX74_07535 ENOG4105EVE HAD-superfamily hydrolase subfamily IA variant 3 HVX74_07540 ENOG4107QWE )-transporter HVX74_07550 ENOG4105CHM Aminotransferase HVX74_07555 ENOG4107NQ8 LysR family Transcriptional regulator HVX74_07575 ENOG4105GKE subunit e HVX74_07580 ENOG4107QIZ NADH dehydrogenase HVX74_07585 ENOG4108IEH NADH dehydrogenase subunit g HVX74_07600 ENOG4107UFS subunit j HVX74_07610 ENOG4105D65 subunit l HVX74_07615 ENOG4105C8S subunit m HVX74_07625 ENOG4105GDX Domain of unknown function (DUF1877) HVX74_07630 ENOG4107VAM peptidase, m28 HVX74_07635 ENOG4105CP2 von willebrand factor, type a HVX74_07645 ENOG4107YB6 acetyltransferase, (GNAT) family HVX74_07650 ENOG4105TNS Conserved Protein HVX74_07655 ENOG4105E4F Isochorismate synthase HVX74_07670 ENOG4108IPT Naphthoate synthase HVX74_07680 ENOG4105CEY Amp-dependent synthetase and ligase HVX74_07685 ENOG4106GZG polymyxin resistance protein B HVX74_07735 ENOG4108UII YfaZ family HVX74_07740 ENOG4108EWA cinA-like protein HVX74_07745 ENOG4107258 Transcriptional regulator HVX74_07755 ENOG4105CSP Major Facilitator Superfamily HVX74_07765 ENOG4105DNE Transposase HVX74_07770 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) HVX74_07780 ENOG4107R5Y anaerobic glycerol-3-phosphate dehydrogenase, subunit A HVX74_07785 ENOG4105CXY transporter HVX74_07790 ENOG4106MZZ glycerophosphoryl diester phosphodiesterase HVX74_07795 ENOG4105GZI Transcriptional regulator HVX74_07800 ENOG4105CZM Major Facilitator HVX74_07805 ENOG4105FQR PH-inducible protein involved in stress response HVX74_07810 ENOG4105XPH Ferredoxin HVX74_07815 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HVX74_07820 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HVX74_07825 ENOG4107GHC outer membrane autotransporter HVX74_07835 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HVX74_07840 ENOG4107FKF Uncharacterized protein conserved in bacteria (DUF2138) HVX74_07845 ENOG4108QJJ Protein of unknown function (DUF1175) HVX74_07850 ENOG4107S52 alpha-2-macroglobulin domain protein HVX74_07855 ENOG41081SK signal peptide protein HVX74_07860 ENOG4105EDV vault protein HVX74_07865 ENOG4105CHU acetyl-coa acetyltransferase HVX74_07870 ENOG4105CRW Short chain fatty acid transporter HVX74_07875 ENOG4107QNJ CoA-transferase subunit B HVX74_07880 ENOG4107QP7 CoA-transferase subunit A HVX74_07885 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family HVX74_07890 ENOG4105BZU Histidine kinase HVX74_07895 ENOG4105BZU Histidine kinase HVX74_07900 ENOG41068CG regulatoR HVX74_07905 ENOG4105E3G Phosphotransfer intermediate protein in two-component regulatory system with RcsBC HVX74_07910 ENOG4105FCK Membrane HVX74_07915 ENOG4105CJ2 (LipO)protein HVX74_07920 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) HVX74_07925 ENOG4105CF1 Alkylated DNA repair protein HVX74_07930 ENOG4105IBP Cyclic peptide transporter HVX74_07945 ENOG4108ZNS ferredoxin-type protein NapF HVX74_07950 ENOG41061Q0 Assembly protein for periplasmic nitrate reductase HVX74_07960 ENOG4108BGM Quinol dehydrogenase periplasmic component HVX74_07965 ENOG4105GXZ Ferredoxin-type protein NapH HVX74_07970 ENOG4108ZMS Electron transfer subunit of the periplasmic nitrate reductase complex NapAB (By similarity) HVX74_07975 ENOG4105CUW cytochrome C-TYPE protein HVX74_07985 ENOG4105CA5 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes (By similarity) HVX74_07990 ENOG41060IM Heme exporter protein HVX74_07995 ENOG4105X3C heme exporter protein HVX74_08005 ENOG4105DA4 cytochrome c-type biogenesis protein HVX74_08010 ENOG4107QX9 Thiol disulfide interChange protein HVX74_08015 ENOG4105KWW Biogenesis protein HVX74_08020 ENOG4105WH1 Two component transcriptional regulator luxr family HVX74_08035 ENOG4105E68 Sulfatase HVX74_08055 ENOG4105CFI type iii restriction protein res subunit HVX74_08060 ENOG4105I08 Pseudouridine synthase HVX74_08065 ENOG4105C2C drug resistance transporter, Bcr CflA HVX74_08070 ENOG4105HG6 HVX74_08075 ENOG4108JQ5 ABC transporter HVX74_08080 ENOG4108IYQ Binding-protein-dependent transport systems inner membrane component HVX74_08085 ENOG4108I5X binding-protein-dependent transport systems inner membrane Component HVX74_08090 ENOG4105E43 Extracellular solute-binding protein, family 5 HVX74_08095 ENOG4105CXC rtn protein HVX74_08100 ENOG4107TT5 NLP P60 protein HVX74_08105 ENOG41076MN Phosphoesterase, PA-phosphatase related HVX74_08110 ENOG4105CKI cobalamin synthesis protein HVX74_08115 ENOG4105DEI Mannitol dehydrogenase HVX74_08125 ENOG4105KRS Proteinase inhibitor HVX74_08130 ENOG4105S8Q sugar efflux transporter HVX74_08135 ENOG4105DTZ bifunctional PTS system fructose-specific transporter subunit IIA HPr protein HVX74_08140 ENOG4105DE4 1-phosphofructokinase HVX74_08145 ENOG4105DM4 PTS System HVX74_08150 ENOG4105DD7 kinase (PfkB family HVX74_08155 ENOG4105D53 Catalyzes the hydrolysis of pseudouridine 5'-phosphate (PsiMP) to ribose 5-phosphate and uracil (By similarity) HVX74_08160 ENOG4105D9N nucleoside HVX74_08165 ENOG4108Y4K DNA-binding transcriptional activator HVX74_08175 ENOG4105D9N nucleoside HVX74_08180 ENOG4105DD7 kinase (PfkB family HVX74_08190 ENOG4105HMI Membrane HVX74_08195 ENOG4105DUM transcriptional regulator, lysR family HVX74_08200 ENOG4108IQI permease HVX74_08205 ENOG4105D05 Receptor HVX74_08210 ENOG4105C4W S-formylglutathione hydrolase HVX74_08220 ENOG4105DHF Membrane HVX74_08225 ENOG41060NJ transcriptional regulator HVX74_08230 ENOG4105EMA Periplasmic binding protein LacI transcriptional regulator HVX74_08235 ENOG4105C2J ABC transporter HVX74_08240 ENOG4108HWV )-transporter HVX74_08245 ENOG4107SJI Dehydrogenase HVX74_08250 ENOG4105BZ8 glutamate synthase HVX74_08255 ENOG4105Y9N Membrane HVX74_08260 ENOG4107GZ4 SanA protein HVX74_08270 ENOG41067MG lrgb family HVX74_08300 ENOG4108RXX maleylacetoacetate isomerase HVX74_08305 ENOG4105MSY salicylate hydroxylase HVX74_08310 ENOG4105FBT Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity) HVX74_08320 ENOG4105ETP RND efflux system, outer membrane lipoprotein HVX74_08325 ENOG4105H9W Short-chain dehydrogenase reductase Sdr HVX74_08330 ENOG4105KHU inner membrane protein YohD HVX74_08335 ENOG41069YE inner membrane protein yohC HVX74_08340 ENOG41061WM D-Alanyl-D-Alanine HVX74_08345 ENOG4105CXG d-lactate dehydrogenase HVX74_08350 ENOG4107QK4 glycoside hydrolase, family 3 domain protein HVX74_08355 ENOG4107SI7 Substrate-binding region of abc-type glycine betaine transport system HVX74_08360 ENOG4107T5X Binding-protein-dependent transport systems, inner membrane component HVX74_08365 ENOG4108IJ8 ABC transporter HVX74_08370 ENOG4105WJV Binding-protein-dependent transport systems, inner membrane component HVX74_08380 ENOG4108XDN Transcriptional regulator HVX74_08385 ENOG4108HRK Histidine kinase HVX74_08390 ENOG4108NEV two component transcriptional regulator, LytTR family HVX74_08395 ENOG4108W15 Protein of unknown function (DUF1456) HVX74_08400 ENOG4108YCW (LipO)protein HVX74_08405 ENOG410903U zinc ion binding HVX74_08410 ENOG4105DEG Vwa containing coxe family protein HVX74_08415 ENOG4105RD5 HVX74_08420 ENOG4105KKX ATPase associated with various cellular activities aaa_5 HVX74_08430 ENOG4108KDT Molybdate metabolism regulator HVX74_08435 ENOG4108KDT Molybdate metabolism regulator HVX74_08440 ENOG4108KDT Molybdate metabolism regulator HVX74_08445 ENOG4108KDT Molybdate metabolism regulator HVX74_08455 ENOG4105D1F ATP-binding protein HVX74_08460 ENOG41067AK Protein of unknown function (DUF2574) HVX74_08465 ENOG41063W2 Fimbrial protein HVX74_08470 ENOG4108MQF Chaperone HVX74_08475 ENOG4105CW0 outer membrane usher protein HVX74_08480 ENOG410662B Type-1 fimbrial protein HVX74_08485 ENOG4108Z1S Influences nickel and cobalt homeostasis. May act by modulating RcnA-mediated export of these ions to avoid excess efflux. Not involved in nickel import and does not bind nickel or cobalt ions directly HVX74_08490 ENOG41061MD high-affinity nickel-transporter HVX74_08505 ENOG4105DWF phosphomethylpyrimidine kinase HVX74_08510 ENOG4108UQ1 hydrolase, family 25 HVX74_08515 ENOG4105FDP GntR family transcriptional regulator HVX74_08520 ENOG4108TFM Kinase, PfkB family HVX74_08525 ENOG4108KD5 ADP-ribosylation crystallin J1 HVX74_08530 ENOG4105EAA nucleoside HVX74_08535 ENOG4105EIE fructose-bisphosphate aldolase HVX74_08550 ENOG41082GB PTS system galactitol-specific transporter subunit IIA HVX74_08555 ENOG41090UW PTS System HVX74_08560 ENOG4105DT3 PTS system, galactitol-specific IIc component HVX74_08565 ENOG4107WTH Galactitol-1-phosphate dehydrogenase HVX74_08580 ENOG41076Z6 Uncharacterized protein yegR HVX74_08585 ENOG4108IYT Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HVX74_08640 ENOG4108ZF3 Phosphatase HVX74_08645 ENOG4105ED4 portal protein HVX74_08735 ENOG410685N tail fiber protein HVX74_08740 ENOG4105UZW Tail fiber assembly protein HVX74_08780 ENOG4105ZTC transcriptional activator, Ogr delta HVX74_08800 ENOG4105CFP Peptidase U32 HVX74_08805 ENOG4105KWI UPF0339 protein HVX74_08810 ENOG4105E3W Two component transcriptional regulator (Winged helix family HVX74_08815 ENOG4105EB3 Histidine kinase HVX74_08850 ENOG4108M24 von Willebrand factor, type A HVX74_08855 ENOG4105UM3 Inherit from NOG: serine threonine phosphoprotein phosphatase HVX74_08860 ENOG4105ZD5 Uncharacterized protein conserved in bacteria (DUF2314) HVX74_08865 ENOG4106E1W protein with protein kinase and helix-hairpin-helix DNA-binding HVX74_08870 ENOG4105R8A Heat shock protein HVX74_08875 ENOG4105D03 DNA-3-methyladenine glycosylase II HVX74_08880 ENOG4105BZU Histidine kinase HVX74_08885 ENOG4105DBI uridine monophosphokinase HVX74_08895 ENOG4108GAE asmA family HVX74_08900 ENOG4105EE5 Membrane protein terC HVX74_08910 ENOG4105DAY polysaccharide export protein HVX74_08915 ENOG4105KJF protein tyrosine phosphatase HVX74_08920 ENOG4105D75 Capsular exopolysaccharide family HVX74_08925 ENOG41090RK glycosyl transferase HVX74_08930 ENOG41068PY Colanic acid biosynthesis acetyltransferase wcaB HVX74_08935 ENOG4107RXY Glycosyl transferase HVX74_08940 ENOG4108NYJ Colanic acid HVX74_08945 ENOG4105ECJ Glycosyl Transferase HVX74_08950 ENOG4108Z90 colanic acid biosynthesis acetyltransferase wcaF HVX74_08955 ENOG4105C0K Gdp-mannose 4,6-dehydratase HVX74_08960 ENOG4105C30 Nad-dependent epimerase dehydratase HVX74_08965 ENOG4105FGF GDP-mannose mannosyl hydrolase HVX74_08970 ENOG4106CD9 glycosyl transferase group 1 HVX74_08975 ENOG4105CJT Mannose-1-phosphate guanylyltransferase HVX74_08980 ENOG4107QKV phosphomannomutase HVX74_08985 ENOG4105D3Q Sugar transferase HVX74_08990 ENOG4105PSV Polysaccharide Biosynthesis Protein HVX74_08995 ENOG4105C74 pyruvyl transferase HVX74_09000 ENOG4107T8Q Glycosyl transferase (Group 1 HVX74_09005 ENOG4105G1A colanic acid biosynthesis protein HVX74_09010 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase HVX74_09015 ENOG4105C1B dTDP-glucose 4-6-dehydratase HVX74_09020 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase HVX74_09025 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) HVX74_09035 ENOG4105J5G Transferase hexapeptide repeat containing protein HVX74_09045 ENOG4105EGZ biosynthesis protein HVX74_09055 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase HVX74_09080 ENOG410600T transposase HVX74_09095 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) HVX74_09100 ENOG4105C6Y Udp-glucose 6-dehydrogenase HVX74_09125 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) HVX74_09130 ENOG4105ECC imidazole-glycerol-phosphate dehydratase HVX74_09155 ENOG4107SRH Nad-dependent epimerase dehydratase HVX74_09160 ENOG4105EQ1 Transcriptional regulator HVX74_09170 ENOG4105CUB amino acid HVX74_09175 ENOG4105CJB Exodeoxyribonuclease I HVX74_09180 ENOG4105DZ1 carboxypeptidase HVX74_09190 ENOG4105DR8 Membrane HVX74_09200 ENOG4105KTW ethanolamine utilization protein HVX74_09205 ENOG4105M3W utilization protein HVX74_09215 ENOG4107QTR Required for nitrogen fixation. May be part of a membrane complex functioning as an intermediate in the electron transport to nitrogenase (By similarity) HVX74_09220 ENOG4105C0A alcohol dehydrogenase HVX74_09225 ENOG4108EKI Dehydrogenase HVX74_09235 ENOG4105WVM ethanolamine utilization protein EutN carboxysome structural protein Ccml HVX74_09245 ENOG4108VPX Involved in 1,2-propanediol (1,2-PD) degradation by catalyzing the conversion of propanoyl-CoA to propanoyl-phosphate (By similarity) HVX74_09250 ENOG4105KNY Microcompartments protein HVX74_09255 ENOG4105KNY Microcompartments protein HVX74_09265 ENOG41084PW diol glycerol dehydratase reactivating factor large subunit HVX74_09270 ENOG4108ZFT Dehydratase small subunit HVX74_09275 ENOG4105YCI dehydratase medium subunit HVX74_09280 ENOG4105DMB glycerol dehydratase HVX74_09285 ENOG4105EHR propanediol utilization protein pduB HVX74_09290 ENOG4105KNY Microcompartments protein HVX74_09295 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) HVX74_09300 ENOG4107XVH Transcriptional regulator HVX74_09310 ENOG4108P62 biosynthesis protein (CbiG) HVX74_09315 ENOG4108YZT Adenosylcobinamide kinase HVX74_09330 ENOG4108PXI ErfK YbiS YcfS YnhG HVX74_09340 ENOG4108X7Y Mannitol-specific cryptic phosphotransferase enzyme iia HVX74_09345 ENOG4105K18 The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane (By similarity) HVX74_09355 ENOG4108YZG isomerase HVX74_09360 ENOG4105E98 transcriptional regulator DeoR family HVX74_09370 ENOG4105K18 The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane (By similarity) HVX74_09375 ENOG4105DT3 PTS system, galactitol-specific IIc component HVX74_09380 ENOG4105DJV ribulose-phosphate 3-epimerase HVX74_09385 ENOG4105CHR reductase HVX74_09390 ENOG41080HJ 6-phospho 3-hexuloisomerase HVX74_09400 ENOG4106P55 Transcriptional regulator HVX74_09405 ENOG4107R11 Transcriptional regulator HVX74_09415 ENOG4105UQX Mate efflux family protein HVX74_09425 ENOG4105CDY transcriptional regulatory protein HVX74_09430 ENOG4105FYV Amp nucleosidase HVX74_09435 ENOG4105CSH Transporter HVX74_09465 ENOG4108VKM cytochrome b561 HVX74_09470 ENOG4108MEK Metal-binding protein YodA HVX74_09485 ENOG4105VT2 5-hydroxyisourate hydrolase HVX74_09490 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HVX74_09495 ENOG4107ZY3 Histidine kinase HVX74_09510 ENOG4105ZIT Porin Gram-negative type HVX74_09515 ENOG4105Y0K Inner membrane protein YedR HVX74_09520 ENOG4105EST Metal Dependent Phosphohydrolase HVX74_09525 ENOG4105DVF Cytosine-specific methyltransferase HVX74_09530 ENOG41090BB DNA mismatch endonuclease (vsr) HVX74_09535 ENOG4105FDR Membrane HVX74_09540 ENOG4105CKW Inner membrane protein yedI HVX74_09545 ENOG4105VNZ cytoplasmic protein HVX74_09560 ENOG4105YX3 cellular response to acidity HVX74_09570 ENOG4107TKS colanic acid capsular biosynthesis activation protein A HVX74_09575 ENOG4105D19 Role in flagellar biosynthesis (By similarity) HVX74_09585 ENOG4105CN7 Flagellar biosynthetic protein FliP HVX74_09590 ENOG4105K0P flagellar biosynthesis protein HVX74_09595 ENOG4105DD5 Flagellar motor switch protein HVX74_09600 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) HVX74_09605 ENOG4107ZI8 flagellar basal body-associated protein flil HVX74_09610 ENOG4105WF4 Flagellar hook-length control protein HVX74_09615 ENOG4105GSA Flagellar export protein flij HVX74_09620 ENOG4108JIR Flagellum-specific ATP synthase HVX74_09625 ENOG41090PJ Flagellar assembly protein HVX74_09630 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) HVX74_09635 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) HVX74_09640 ENOG4105VQ0 flagellar hook-basal body complex protein fliE HVX74_09645 ENOG4108HF7 Gcn5-related n-acetyltransferase HVX74_09650 ENOG4108RAV Conserved protein HVX74_09660 ENOG41066VF YeeE YedE family protein HVX74_09665 ENOG4108W9D (LipO)protein HVX74_09670 ENOG4105E5K Alpha-amylase HVX74_09675 ENOG4105YXP it directly binds FlhC, thus inhibiting the binding of the FlhC FlhD complex to class 2 promoters, resulting in decreased expression of class 2 flagellar operons. As a chaperone, effects FliD transition to the membrane by preventing its premature polymerization, and by directing it to the export apparatus (By similarity) HVX74_09680 ENOG4105MQ3 flagellar protein FliS HVX74_09685 ENOG4105DTS flagellar hook-associated HVX74_09690 ENOG4105I03 Flagellin HVX74_09695 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HVX74_09700 ENOG4108M9K flagella biosynthesis protein FliZ HVX74_09705 ENOG4105EAB amino acid AbC transporter HVX74_09710 ENOG4105K6H D-cysteine desulfhydrase HVX74_09715 ENOG4105E5Q amino acid AbC transporter HVX74_09720 ENOG4105CDA abc transporter atp-binding protein HVX74_09725 ENOG4105VJY transcriptional regulator HVX74_09730 ENOG4105XVG cytoplasmic protein HVX74_09740 ENOG4105WH1 Two component transcriptional regulator luxr family HVX74_09770 ENOG4106RHG Yeca family HVX74_09775 ENOG4105E0U tyrosine-specific transport protein HVX74_09780 ENOG4105VVZ metal-binding protein HVX74_09785 ENOG41090A1 ferritin HVX74_09790 ENOG4105P23 (LipO)protein HVX74_09800 ENOG4105N4N Protein of unknown function (DUF2766) HVX74_09805 ENOG4108UEC Ferritin-like protein HVX74_09810 ENOG4105DMK Periplasmic binding protein LacI transcriptional regulator HVX74_09815 ENOG4105C2J ABC transporter HVX74_09820 ENOG4105CNN ABC, transporter HVX74_09825 ENOG4108K4C ec 3.1.3.12 HVX74_09835 ENOG4108VA4 Universal stress protein HVX74_09845 ENOG4106CIA Functions in complex with FlhD as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region HVX74_09850 ENOG4107RD7 Flagellar Motor Protein, MotA HVX74_09855 ENOG4105ER2 Ompa motb domain protein HVX74_09860 ENOG4105CBS Chea signal transduction histidine kinase HVX74_09865 ENOG4108V3W Chemotaxis protein, CheW HVX74_09870 ENOG4105C8Q Methyl-accepting chemotaxis HVX74_09875 ENOG4105C8Q Methyl-accepting chemotaxis HVX74_09880 ENOG4105BZU Histidine kinase HVX74_09890 ENOG4108VYJ response regulator receiver protein HVX74_09895 ENOG4108KCC Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P) (By similarity) HVX74_09900 ENOG4105D00 flagellar biosynthetic protein flhB HVX74_09905 ENOG4105D7B Flagellar biosynthesis protein flha HVX74_09910 ENOG4105W13 flagellar protein HVX74_09920 ENOG4106ZCM YecM protein HVX74_09930 ENOG4105CUW cytochrome C-TYPE protein HVX74_09935 ENOG4107QY8 reductase HVX74_09950 ENOG4105WJG Glutathione HVX74_09955 ENOG41081XQ Conserved Protein HVX74_09960 ENOG4105D3W isochorismatase HVX74_09970 ENOG4108TIT dATP pyrophosphohydrolase HVX74_09975 ENOG4105CDY transcriptional regulatory protein HVX74_09985 ENOG4107S01 Repressor protein MetJ HVX74_10005 ENOG4105FAV ABC, transporter HVX74_10015 ENOG4105NXV High-affinity zinc uptake system protein HVX74_10020 ENOG4105DR5 peptidase HVX74_10025 ENOG4105NWR lipid A biosynthesis (Kdo)2-(Lauroyl)-lipid IVA acyltransferase HVX74_10030 ENOG4105CA9 Pyruvate kinase HVX74_10035 ENOG4106KNT transcriptional regulator HVX74_10040 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase HVX74_10045 ENOG4105C01 Dihydroxy-acid dehydratase HVX74_10050 ENOG4108UHU Aldolase HVX74_10060 ENOG4105X2V dna damage-inducible protein HVX74_10070 ENOG4108Q2J Inner membrane protein YebE HVX74_10075 ENOG4105CUG Oligopeptidase b HVX74_10080 ENOG4105UMD exodeoxyribonuclease X HVX74_10085 ENOG4108YGA nitrilase cyanide hydratase and apolipoprotein n-acyltransferase HVX74_10090 ENOG4105MPK DNA polymerase III subunit theta HVX74_10095 ENOG4105FXM Copper resistance protein HVX74_10100 ENOG4108PNC copper resistance HVX74_10105 ENOG4105NKT exported protein HVX74_10110 ENOG4108R1E Serine threonine protein phosphatase 1 HVX74_10115 ENOG4105UVW uncharacterized protein yebW HVX74_10120 ENOG4105WT8 Protein of unknown function (DUF1480) HVX74_10130 ENOG4105DY2 Paraquat-inducible protein b HVX74_10135 ENOG4105H2K paraquat-inducible protein a HVX74_10140 ENOG4108ZGC gaf domain protein HVX74_10150 ENOG4105CN1 protease HVX74_10160 ENOG4105C0R drug resistance transporter emrb qaca subfamily HVX74_10165 ENOG4105J4Q Transcriptional regulator HVX74_10170 ENOG4105TIK HVX74_10180 ENOG4105Q3Y exported protein HVX74_10195 ENOG4105DHI Methyltransferase HVX74_10210 ENOG4105F3R pts system mannose fructose sorbose family iid HVX74_10215 ENOG4105ETZ PTS System HVX74_10220 ENOG4105DAS pts system HVX74_10225 ENOG4105EE5 Membrane protein terC HVX74_10230 ENOG4107XTP (EAL) domain protein HVX74_10235 ENOG4105EJQ L-serine dehydratase HVX74_10245 ENOG4105CRQ synthase (Component I) HVX74_10255 ENOG4105V2F Uncharacterized protein yoac HVX74_10260 ENOG4105M4H endoribonuclease L-psp HVX74_10265 ENOG4105DVT helicase HVX74_10270 ENOG41072GX Peptidase M22 Glycoprotease HVX74_10275 ENOG4105Y4Z Outer Membrane Lipoprotein HVX74_10280 ENOG4105CEY Amp-dependent synthetase and ligase HVX74_10285 ENOG4105ZIE Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity) HVX74_10290 ENOG4105E3J oxidoreductase HVX74_10295 ENOG4105DVW rieske (2Fe-2S) HVX74_10300 ENOG4105C94 Transporter HVX74_10305 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) HVX74_10310 ENOG4105EJC lysr family transcriptional regulator HVX74_10320 ENOG4108YS1 cytoplasmic protein HVX74_10325 ENOG4105YP6 Domain of unknown function (DUF1869) HVX74_10330 ENOG4105Y3U Transglycosylase-associated protein HVX74_10340 ENOG4106G4W HVX74_10345 ENOG410620I Diguanylate cyclase HVX74_10350 ENOG4105UCG Domain of unknown function (DUF333) HVX74_10355 ENOG4105K78 MarR family Transcriptional regulator HVX74_10360 ENOG4105DJ2 Major Facilitator Superfamily HVX74_10365 ENOG4105R1U AraC Family Transcriptional Regulator HVX74_10380 ENOG4108KXH Ybak prolyl-tRNA synthetase associated HVX74_10385 ENOG4108KHP Diguanylate cyclase HVX74_10390 ENOG4106KTS Inner membrane protein yeaI HVX74_10400 ENOG4105CYN Serine protein kinase HVX74_10405 ENOG4105GNX MltA-interacting MipA family protein HVX74_10410 ENOG4105CV8 reductase HVX74_10415 ENOG4105DSB aldose 1-epimerase HVX74_10420 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase HVX74_10430 ENOG4105VUT cytoplasmic protein HVX74_10440 ENOG4105D2N Aldolase HVX74_10445 ENOG4107UH8 sugar kinase HVX74_10450 ENOG4105CPC Aldo Keto reductase HVX74_10455 ENOG4105E98 transcriptional regulator DeoR family HVX74_10460 ENOG4108KUU Inner membrane metabolite transport protein ydjE HVX74_10465 ENOG4108RWI nicotinamidase HVX74_10470 ENOG4105HDK L-asparaginase HVX74_10475 ENOG4105D07 Signal peptide peptidase, SppA HVX74_10480 ENOG41069NU Nitroreductase HVX74_10485 ENOG4105D4F Synthesizes selenophosphate from selenide and ATP (By similarity) HVX74_10490 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) HVX74_10495 ENOG4105F7F Chaperone HVX74_10500 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) HVX74_10505 ENOG4105D82 Glutamate dehydrogenase HVX74_10510 ENOG4105MTM Protein of unknown function (DUF1496) HVX74_10515 ENOG4105M6F mutator MutT protein HVX74_10520 ENOG4108T9J Cdp-alcohol phosphatidyltransferase HVX74_10525 ENOG4107RM6 sulfurtransferase HVX74_10530 ENOG4108VGW abc transporter atp-binding protein HVX74_10535 ENOG4105CXZ ABC transporter, permease HVX74_10540 ENOG4105VNH ABC transporter solute-binding protein HVX74_10545 ENOG4107ZN8 Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) HVX74_10550 ENOG4108N5C SNARE associated Golgi protein-related protein HVX74_10555 ENOG4108KCW iron-sulfur cluster binding HVX74_10560 ENOG4108RSN SNARE associated Golgi HVX74_10565 ENOG4105CGK Exodeoxyribonuclease III HVX74_10580 ENOG4105C26 Dehydrogenase HVX74_10590 ENOG4107UI5 Transforms N(2)-succinylglutamate into succinate and glutamate (By similarity) HVX74_10595 ENOG4108SPG Periplasmic Protein HVX74_10605 ENOG4105DKD Incises the DNA at the 3' side of a lesion during nucleotide excision repair. Incises the DNA farther away from the lesion than UvrC. Not able to incise the 5' site of a lesion. When a lesion remains because UvrC is not able to induce the 3' incision, Cho incises the DNA. Then UvrC makes the 5' incision. The combined action of Cho and UvrC broadens the substrate range of nucleotide excision repair (By similarity) HVX74_10615 ENOG4105KKI DNA-binding transcriptional activator OsmE HVX74_10620 ENOG4105VZJ PTS System HVX74_10625 ENOG4105CK1 PTS System HVX74_10630 ENOG4105VCP PTS System HVX74_10635 ENOG4105EZV Transcriptional regulator HVX74_10640 ENOG4105F8D glycoside hydrolase family 4 HVX74_10645 ENOG410901P UPF0249 protein HVX74_10650 ENOG4105CH6 catalase HVX74_10665 ENOG4108ETY sodium dicarboxylate symporter HVX74_10670 ENOG4107K5X Membrane-bound metal-dependent hydrolase HVX74_10675 ENOG4107UW8 HAD-superfamily hydrolase subfamily IA variant 3 HVX74_10680 ENOG4107PN8 YfeABCD locus regulator HVX74_10690 ENOG4105P10 Uncharacterized protein ydiZ HVX74_10695 ENOG4105DE4 1-phosphofructokinase HVX74_10700 ENOG4108NE3 Salt-induced outer membrane protein HVX74_10720 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) HVX74_10725 ENOG41082NX 50s ribosomal protein l35 HVX74_10760 ENOG4108V06 Glutathione peroxidase HVX74_10770 ENOG4108QBX (LipO)protein HVX74_10775 ENOG4108TC0 Diguanylate phosphodiesterase HVX74_10790 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) HVX74_10800 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) HVX74_10805 ENOG4107QPK )-transporter HVX74_10810 ENOG4105C5I Dehydrogenase HVX74_10820 ENOG41061TZ Short-chain dehydrogenase reductase Sdr HVX74_10825 ENOG4105CEY Amp-dependent synthetase and ligase HVX74_10830 ENOG41090P5 ferredoxin-like protein HVX74_10835 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase HVX74_10840 ENOG4105C10 Electron transfer flavoprotein HVX74_10845 ENOG4105CV7 Electron transfer flavoprotein HVX74_10850 ENOG4105W4W Transcriptional regulator HVX74_10855 ENOG4105C1G acyl-Coa dehydrogenase HVX74_10860 ENOG4108IIG CoA transferase having broad substrate specificity for short-chain acyl-CoA thioesters with the activity decreasing when the length of the carboxylic acid chain exceeds four carbons (By similarity) HVX74_10875 ENOG4105EMV Major Facilitator HVX74_10880 ENOG4105EMV Major Facilitator HVX74_10885 ENOG4105SUA Ydil protein HVX74_10895 ENOG4105IPI Membrane HVX74_10900 ENOG4105CQB FAD linked oxidase domain protein HVX74_10905 ENOG4105KA0 thioesterase Superfamily protein HVX74_10910 ENOG410671Z uncharacterized protein ydiH HVX74_10915 ENOG4108Z4V iron-sulfur cluster assembly HVX74_10920 ENOG4105DIW FeS assembly protein SUFB HVX74_10925 ENOG4105C3K feS assembly ATPase SufC HVX74_10930 ENOG4105JRK feS assembly protein SufD HVX74_10945 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein HVX74_10950 ENOG4105KMX major outer membrane lipoprotein HVX74_10955 ENOG4105CA9 Pyruvate kinase HVX74_10960 ENOG4105RFR Protein of unknown function (DUF2767) HVX74_10965 ENOG4108PU5 4fe-4S ferredoxin, iron-sulfur binding domain protein HVX74_10970 ENOG4105WE2 aldehyde ferredoxin oxidoreductase HVX74_10975 ENOG4105JVW HVX74_10980 ENOG4108393 oxidoreductase Fe-S subunit HVX74_10985 ENOG4108NWD Cytochrome HVX74_10990 ENOG4108Y7C Conserved Protein HVX74_10995 ENOG4108KTU conserved protein with FAD NAD(P)-binding domain HVX74_11000 ENOG4105N0V mono-oxygenase ydhR HVX74_11020 ENOG4107QI1 Mate efflux family protein HVX74_11025 ENOG4108R6K riboflavin synthase, subunit alpha HVX74_11030 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase HVX74_11035 ENOG4105CZQ inner membrane transport protein YdhC HVX74_11040 ENOG4105F52 Transcriptional regulator HVX74_11055 ENOG4105F27 Major Facilitator HVX74_11060 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) HVX74_11065 ENOG4105K4H Nlp p60 protein HVX74_11070 ENOG4105M2J Glutaredoxin HVX74_11075 ENOG4107QRT dEAD DEAH box helicase HVX74_11085 ENOG4108UYE Lactoylglutathione lyase HVX74_11090 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HVX74_11095 ENOG4108WUH Transcriptional regulator, TetR family HVX74_11100 ENOG4105XZD Fe-S protein HVX74_11105 ENOG4107RGM aldo keto reductase HVX74_11110 ENOG4108Z7T Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) HVX74_11115 ENOG4105DSW Fusaric acid resistance protein HVX74_11120 ENOG4105Y49 secretion protein, HlyD family HVX74_11135 ENOG4108XTF Outer Membrane Lipoprotein HVX74_11145 ENOG410642K Lysozyme inhibitor HVX74_11160 ENOG4107XGF functions in a salvage pathway. Uses pyridoxamine (By similarity) HVX74_11165 ENOG4108K3A Glutathione S-transferase HVX74_11170 ENOG4105DUX Transporter HVX74_11175 ENOG4105CSM endonuclease III HVX74_11185 ENOG4108UQQ Electron transport complex HVX74_11210 ENOG4105M9B inner membrane protein ydgK HVX74_11215 ENOG4105QZ5 OriC-binding nucleoid-associated protein HVX74_11220 ENOG4106C6R beta-lactam resistance protein HVX74_11225 ENOG4105D9R oxidoreductase HVX74_11235 ENOG4105C87 Aminotransferase class I and II HVX74_11245 ENOG4107R08 Integrase HVX74_11260 ENOG4106G8A Qin prophage HVX74_11345 ENOG4108MXB Protein of unknown function (DUF968) HVX74_11350 ENOG4105KSK (crossover) junction endodeoxyribonuclease HVX74_11415 ENOG4105QYK bacteriophage lambda Bor protein homolog HVX74_11430 ENOG4105UZW Tail fiber assembly protein HVX74_11455 ENOG4105IM0 capsid protein HVX74_11525 ENOG4108X9F tail fiber protein HVX74_11530 ENOG4105UZW Tail fiber assembly protein HVX74_11540 ENOG4107P2S Transcriptional regulator HVX74_11545 ENOG4107ZQV short-chain dehydrogenase reductase HVX74_11550 ENOG4105XEA Tetr family transcriptional regulator HVX74_11555 ENOG4105CNT hydrolase family 2 HVX74_11560 ENOG4105CT4 transporter HVX74_11565 ENOG4108QNI outer membrane porin protein HVX74_11570 ENOG4106J39 exported protein HVX74_11575 ENOG4105EIP mannose-6-phosphate isomerase HVX74_11580 ENOG4107GFK fumarate HVX74_11585 ENOG4105C9Q fumarate hydratase class II HVX74_11595 ENOG4105JJR Histidine kinase HVX74_11600 ENOG4107EXC regulatoR HVX74_11605 ENOG4105RA2 Membrane HVX74_11615 ENOG4105D5Q Arginine ornithine antiporter HVX74_11620 ENOG4105C5D exported protein HVX74_11625 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) HVX74_11630 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) HVX74_11635 ENOG4105DSF transport protein HVX74_11650 ENOG4105CVW peptidase s1 and s6 chymotrypsin hap HVX74_11665 ENOG4105D94 Major Facilitator Superfamily HVX74_11670 ENOG4106NZI LysR family Transcriptional regulator HVX74_11675 ENOG4105DAG ROK family HVX74_11680 ENOG4105EWW Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) HVX74_11690 ENOG4108NEM leader-binding protein dmsD HVX74_11695 ENOG4107KGK dmso reductase anchor subunit HVX74_11700 ENOG4105QAX Iron-sulfur HVX74_11705 ENOG4105C3J Cysteine desulfurase HVX74_11710 ENOG4107QY8 reductase HVX74_11715 ENOG4105KBG Protein of unknown function (DUF1161) HVX74_11725 ENOG4108MK9 spermidine N(1)-acetyltransferase HVX74_11740 ENOG4105CXK mandelate racemase muconate lactonizing HVX74_11745 ENOG4105CPQ Dehydrogenase HVX74_11750 ENOG4105GQU Trap dicarboxylate transporter, dctp subunit HVX74_11760 ENOG4105CG6 trap dicarboxylate transporter dctm subunit HVX74_11765 ENOG4105GQU Trap dicarboxylate transporter, dctp subunit HVX74_11780 ENOG4105DEI Mannitol dehydrogenase HVX74_11785 ENOG41061EV selenium-binding protein YdfZ HVX74_11790 ENOG4107XBN GntR Family Transcriptional Regulator HVX74_11795 ENOG4105EMU Dehydrogenase HVX74_11800 ENOG4105DGW oligopeptidase A HVX74_11805 ENOG4108WTK competence damage-inducible protein HVX74_11810 ENOG4108YDI single-species biofilm formation on inanimate substrate HVX74_11815 ENOG4105FSR swimming returnes to normal when residues 206-207 are both mutated to Ala. Overexpression also leads to a reduction in flagellar abundance and a 20-fold increase in c-di- GMP levels in vivo. Required for aminoglycoside-mediated induction of biofilm formation, it also plays a lesser role in biofilm production in response to other classes of translation inhibitors. The c-di-GMP produced by this enzyme up-regulates poly-GlcNAc production as well as the biofilm synthesis protein PgaD, although c-di-GMP is probably not the main inducing principle. Cyclic-di- GMP is a second messenger which controls cell surface-associated traits in bacteria HVX74_11825 ENOG4105E5W Transporter HVX74_11830 ENOG4108594 Permease of the drug metabolite transporter HVX74_11835 ENOG4105FDP GntR family transcriptional regulator HVX74_11845 ENOG4105CK1 PTS System HVX74_11850 ENOG4105VCP PTS System HVX74_11860 ENOG4105CS2 ec 3.2.1.21 HVX74_11865 ENOG4106DNR multiple antibiotic resistance protein HVX74_11870 ENOG4108XW0 May be a transcriptional activator of genes involved in the multiple antibiotic resistance (Mar) phenotype. It can also activate genes such as sodA, zwf and micF HVX74_11875 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes HVX74_11895 ENOG4105EGI Transcriptional regulator HVX74_11900 ENOG4105C26 Dehydrogenase HVX74_11905 ENOG4105CSV Glutaminase HVX74_11910 ENOG4105M0C cytoplasmic protein HVX74_11915 ENOG4105BZU Histidine kinase HVX74_11925 ENOG4105FFC UPF0187 protein HVX74_11935 ENOG4105K34 Involved in the degradation of phospho-AI-2, thereby terminating induction of the lsr operon and closing the AI-2 signaling cycle. Catalyzes the cleavage of phosphorylated 4,5- dihydroxy-2,3-pentanedione (P-DPD) to 2-phosphoglycolic acid (PG) and another three-carbon compound HVX74_11970 ENOG4108EMV Catalyzes the phosphorylation of autoinducer 2 (AI-2) to phospho-AI-2, which subsequently inactivates the transcriptional regulator LsrR and leads to the transcription of the lsr operon. Phosphorylates the ring-open form of 4,5-dihydroxy-2,3- pentanedione (DPD), which is the precursor to all AI-2 signaling molecules, at the C5 position (By similarity) HVX74_11975 ENOG41061P8 Persistence to inhibition of murein or DNA biosynthesis regulatory protein HVX74_11980 ENOG4105CAF HipA N-terminal domain protein HVX74_12000 ENOG4105CW0 outer membrane usher protein HVX74_12005 ENOG4108WDE Fimbrial protein HVX74_12010 ENOG4106318 fimbrial-like protein YdeR HVX74_12015 ENOG4106PIH fimbrial-like protein ydeQ HVX74_12020 ENOG4107QKC Oxidoreductase alpha (molybdopterin) subunit HVX74_12030 ENOG4108NKV transcriptional regulator HVX74_12035 ENOG4105ENH Sulfatase HVX74_12040 ENOG4105C4X radical SAM domain protein HVX74_12050 ENOG4105CQ0 ABC transporter HVX74_12055 ENOG4105PE1 Receptor HVX74_12060 ENOG4107RAN Peptidase, M16 HVX74_12065 ENOG4105CVK Glutamate decarboxylase HVX74_12070 ENOG4105E5D amino acid HVX74_12075 ENOG4105F32 YngK protein HVX74_12085 ENOG4105BZU Histidine kinase HVX74_12090 ENOG4105BZU Histidine kinase HVX74_12095 ENOG4108UQS dipeptidase HVX74_12110 ENOG4107H6U ABC transporter HVX74_12115 ENOG4108Z9K Osmotically inducible protein HVX74_12120 ENOG4105TPS biofilm-dependent modulation protein HVX74_12125 ENOG4107AV5 Although this protein associates with the 30S subunit of the ribosome it is not considered to be a bona fide ribosomal protein HVX74_12135 ENOG4105DQ4 alcohol dehydrogenase HVX74_12140 ENOG41084S7 Plasmid maintenance system antidote protein HVX74_12145 ENOG4108MG3 formate dehydrogenase HVX74_12150 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein HVX74_12160 ENOG4105RPH Inner membrane protein YddG HVX74_12170 ENOG4107QND Nitrite extrusion protein HVX74_12175 ENOG4105CRU nitrate reductase, alpha subunit HVX74_12180 ENOG4108IUE nitrate reductase beta subunit HVX74_12185 ENOG4108NZN Respiratory nitrate reductase 2 delta chain HVX74_12190 ENOG4105D0D Nitrate reductase 2, gamma subunit HVX74_12195 ENOG4105JAB phenazine biosynthesis protein, phzf family HVX74_12200 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase HVX74_12205 ENOG4108MEJ flavin reductase domain protein HVX74_12210 ENOG410600T transposase HVX74_12240 ENOG4105CS6 Rhs element vgr protein HVX74_12255 ENOG4105C85 amino acid HVX74_12260 ENOG4108NS2 receptor HVX74_12265 ENOG4105CHB tonB-dependent Receptor HVX74_12270 ENOG4108WYP Transcriptional regulator HVX74_12275 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein HVX74_12280 ENOG4108Z7F N-acetyltransferase HVX74_12285 ENOG4108T9Y Inner membrane protein ydcZ HVX74_12290 ENOG4105R71 cytoplasmic protein HVX74_12295 ENOG410654E Membrane HVX74_12315 ENOG4105NRK Binding-protein-dependent transport systems, inner membrane component HVX74_12320 ENOG4105D81 ABC transporter, permease HVX74_12325 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HVX74_12330 ENOG4107TYH extracellular solute-binding protein family 1 HVX74_12335 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HVX74_12345 ENOG4105RR0 Protein of unknown function (DUF2554) HVX74_12350 ENOG4105CFP Peptidase U32 HVX74_12355 ENOG4108JCI Transcriptional regulator HVX74_12360 ENOG4105DKK Benzoate HVX74_12365 ENOG4108KKZ (LipO)protein HVX74_12370 ENOG41088CC tellurite resistance protein tehB HVX74_12375 ENOG4108NKP c4-dicarboxylate transporter malic acid transport protein HVX74_12380 ENOG4107WE3 acetyltransferase YdcK HVX74_12385 ENOG4108Z9I -acetyltransferase HVX74_12390 ENOG4105Z2P Protein of unknown function (DUF465) HVX74_12400 ENOG4105E32 cytoplasmic protein HVX74_12405 ENOG4105DDW LysR family Transcriptional regulator HVX74_12410 ENOG4105C8Q Methyl-accepting chemotaxis HVX74_12415 ENOG4107NK6 Hok/gef family HVX74_12420 ENOG4105UPP uncharacterized protein ydcA HVX74_12425 ENOG4105CPW cytochrome b561 HVX74_12430 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase HVX74_12435 ENOG4105C26 Dehydrogenase HVX74_12440 ENOG4107DB1 DUF218 domain HVX74_12455 ENOG4105CQ7 ATP-dependent helicase HVX74_12460 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) HVX74_12465 ENOG41077RS Phosphatase HVX74_12470 ENOG4105E8V Alpha Beta Hydrolase Fold protein HVX74_12475 ENOG4108HPI phosphatidate Cytidylyltransferase HVX74_12480 ENOG4108UMZ Cdp-alcohol phosphatidyltransferase HVX74_12490 ENOG4107S5I aldo keto reductase HVX74_12505 ENOG4108WFR AraC Family Transcriptional Regulator HVX74_12510 ENOG4105WXT Conserved Protein HVX74_12515 ENOG410689M (LipO)protein HVX74_12520 ENOG4107H52 Dicarboxylate transport HVX74_12525 ENOG4105C5I Dehydrogenase HVX74_12530 ENOG41090X5 Heat shock protein hslJ HVX74_12535 ENOG4105IKK cytoplasmic protein HVX74_12540 ENOG4105D95 Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity) HVX74_12545 ENOG4105FCK Membrane HVX74_12550 ENOG4108RW8 Universal stress protein F HVX74_12560 ENOG4108YXQ IS66 Orf2 family protein HVX74_12565 ENOG4105E5H Transposase HVX74_12570 ENOG4105UZW Tail fiber assembly protein HVX74_12575 ENOG4108X9F tail fiber protein HVX74_12610 ENOG4108T1M outer membrane protein x HVX74_12690 ENOG4108ES9 ParB domain protein nuclease HVX74_12745 ENOG4106DF6 pertussis toxin subunit 1 HVX74_12755 ENOG4105RWQ Protein of unknown function (DUF1364) HVX74_12805 ENOG4105JBR DNA replication protein HVX74_12810 ENOG4105ZTP Protein of unknown function (DUF1376) HVX74_12825 ENOG41087BU transcriptional repressor DicA HVX74_12850 ENOG4107C82 Rac prophage HVX74_12860 ENOG41076J9 exonuclease VIII HVX74_12865 ENOG4108PNI recT protein HVX74_12870 ENOG4106YAH restriction alleviation and modification enhancement HVX74_12875 ENOG41070YT Rac prophage HVX74_12880 ENOG4107160 Rac prophage HVX74_12885 ENOG4107R08 Integrase HVX74_12895 ENOG4105C1J atp-dependent rna helicase HVX74_12905 ENOG4105BZU Histidine kinase HVX74_12910 ENOG4108DG9 Smr protein MutS2 HVX74_12915 ENOG4106KR7 LysR family Transcriptional regulator HVX74_12920 ENOG4105CH2 amidohydrolase HVX74_12925 ENOG4107RT5 aminobenzoyl-glutamate utilization protein B HVX74_12930 ENOG4105CFC Transporter HVX74_12935 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) HVX74_12940 ENOG4105DS0 Transcriptional regulator, Crp Fnr family HVX74_12945 ENOG4105Q9Y Universal stress protein HVX74_12950 ENOG4105S5I Membrane HVX74_12955 ENOG4105D64 Mechanosensitive ion channel HVX74_12960 ENOG4107QSI ABC, transporter HVX74_12965 ENOG4105KXI murein peptide amidase A HVX74_12970 ENOG4107S8C mandelate racemase muconate lactonizing HVX74_12975 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) HVX74_12980 ENOG4108JU8 Transcriptional regulator HVX74_12990 ENOG4105CM6 amino acid regulated cytosolic protein HVX74_12995 ENOG4105FKQ transcriptional regulator HVX74_13010 ENOG4105HS6 binding-protein-dependent transport systems inner membrane Component HVX74_13015 ENOG4105WEM extracellular solute-binding protein HVX74_13020 ENOG4107QW3 Sucrose phosphorylase HVX74_13025 ENOG4105K8Z Phage shock protein HVX74_13030 ENOG4105NNG Peripheral inner membrane phage-shock protein HVX74_13035 ENOG4105FM1 phage shock protein C HVX74_13040 ENOG4105YYT phage shock protein B HVX74_13045 ENOG41087YS Phage shock protein A HVX74_13050 ENOG4105E51 psp operon transcriptional activator HVX74_13055 ENOG4108JPW Aminotransferase HVX74_13060 ENOG4105CJP fad dependent oxidoreductase HVX74_13065 ENOG4105C26 Dehydrogenase HVX74_13070 ENOG4107VRI Transcriptional regulator HVX74_13075 ENOG4108Z86 Glutamine amidotransferase HVX74_13080 ENOG4105CFQ glutamine synthetase HVX74_13090 ENOG4105CUB amino acid HVX74_13095 ENOG4105N0E Protein of unknown function (DUF2543) HVX74_13100 ENOG4108HIY periplasmic HVX74_13105 ENOG4108I5W peptide transport system, permease protein HVX74_13110 ENOG4108EU3 peptide transport system, permease HVX74_13115 ENOG4108JQ3 Peptide ABC transporter ATP-binding protein HVX74_13120 ENOG4108JQ2 peptide transport system atp-binding protein HVX74_13130 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH HVX74_13135 ENOG4105Q4T oxidoreductase HVX74_13150 ENOG4105BZU Histidine kinase HVX74_13155 ENOG410643D UPF0509 protein HVX74_13160 ENOG4105N2W Transcriptional regulator HVX74_13170 ENOG4108ZJT translation initiation factor, Sui1 HVX74_13180 ENOG4105CFV Tetratricopeptide repeat protein HVX74_13185 ENOG4105Q4A inner membrane protein yciS HVX74_13190 ENOG4105EYK Phosphatidylglycerophosphatase B HVX74_13200 ENOG4107QM5 aconitate hydratase HVX74_13220 ENOG4107R11 Transcriptional regulator HVX74_13225 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) HVX74_13230 ENOG4105RKX Protein of unknown function (DUF2498) HVX74_13235 ENOG4105ERU peptidase HVX74_13240 ENOG4105UBK short-chain dehydrogenase reductase HVX74_13245 ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase HVX74_13250 ENOG4105FE9 pseudouridine synthase HVX74_13255 ENOG4105EG3 transmembrane signal peptide protein HVX74_13260 ENOG4107RTD sua5 ycio yrdc ywlc family protein HVX74_13265 ENOG4105DB7 PHP domain protein HVX74_13275 ENOG4105CRQ synthase (Component I) HVX74_13280 ENOG4108EFP Anthranilate synthase component II HVX74_13285 ENOG4105DK0 Indole-3-glycerol phosphate synthase HVX74_13295 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) HVX74_13305 ENOG4108Z9Z response to DNA damage stimulus HVX74_13310 ENOG4108N8X transition metal ion binding HVX74_13315 ENOG4105EIF outer membrane protein W HVX74_13335 ENOG4105NAU thioesterase Superfamily protein HVX74_13340 ENOG410822N TonB family HVX74_13345 ENOG4105K9H YciI-like protein HVX74_13350 ENOG4107SVH Potassium channel protein HVX74_13370 ENOG4108JQ7 (ABC) transporter HVX74_13375 ENOG4105C3U ABC transporter HVX74_13380 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HVX74_13385 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HVX74_13390 ENOG4108J59 Extracellular solute-binding protein, family 5 HVX74_13400 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein HVX74_13405 ENOG4105C0A alcohol dehydrogenase HVX74_13410 ENOG4107104 thymidine kinase HVX74_13415 ENOG4108SAU DNA-binding protein H-ns HVX74_13420 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase HVX74_13425 ENOG4105I93 response regulator HVX74_13430 ENOG4105D78 K07001 NTE family protein HVX74_13440 ENOG4105CIY formyltetrahydrofolate deformylase HVX74_13455 ENOG41076YT nitrate reductase, gamma subunit HVX74_13460 ENOG4105R3A Nitrate reductase HVX74_13465 ENOG4108IUE nitrate reductase beta subunit HVX74_13470 ENOG4105CRU nitrate reductase, alpha subunit HVX74_13475 ENOG4105DQQ Major facilitator superfamily MFS_1 HVX74_13480 ENOG4105BZU Histidine kinase HVX74_13485 ENOG4105WH1 Two component transcriptional regulator luxr family HVX74_13490 ENOG4105ID0 Putative invasin HVX74_13495 ENOG41090EX DsrE family HVX74_13500 ENOG4108NH8 Cation transport protein HVX74_13505 ENOG4105WS7 Cation transport regulator HVX74_13510 ENOG4105EWV Sodium calcium exchanger membrane region HVX74_13530 ENOG41063JG Transcriptional regulator HVX74_13535 ENOG4108YY7 Invasion gene expression up-regulator SirB HVX74_13540 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) HVX74_13550 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) HVX74_13565 ENOG4105C5T Phosphoribosyl pyrophosphate synthase HVX74_13570 ENOG4105CHH sulfate transporter HVX74_13575 ENOG4105MGX transcription activated by CRP (cyclic AMP receptor protein), a global transcription factor involved in regulation of metabolism in enteric bacteria HVX74_13585 ENOG4105C3G gtp-binding protein HVX74_13590 ENOG4105I1J Autotransporter HVX74_13595 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family HVX74_13600 ENOG4105CMT Dihydroxyacetone kinase HVX74_13605 ENOG4108UTZ Dihydroxyacetone kinase HVX74_13610 ENOG4105VDH Dihydroxyacetone kinase HVX74_13615 ENOG4105E53 ec 3.2.1.28 HVX74_13620 ENOG4105S10 periplasmic binding protein HVX74_13625 ENOG4105EHG Permease protein HVX74_13630 ENOG4105E0A ABC, transporter HVX74_13635 ENOG4108BSC Methyltransferase HVX74_13640 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase HVX74_13655 ENOG4108T7K Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Increasing levels of c-di-GMP lead to decreased motility (By similarity) HVX74_13665 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A HVX74_13675 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) HVX74_13685 ENOG4105ED1 spovr family HVX74_13700 ENOG410635M Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein (By similarity) HVX74_13705 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) HVX74_13710 ENOG4105KT5 UmuD protein HVX74_13715 ENOG4106PXS Toxin, which has some hemolytic activity towards mammalian cells. Acts by forming a pore-like structure upon contact with mammalian cells HVX74_13725 ENOG4105FBJ fumarylacetoacetate (faa) hydrolase HVX74_13735 ENOG41066UD Inhibits activity of g-type lysozyme, which confers increased lysozyme tolerance to the bacterium HVX74_13740 ENOG4105S66 prophage protein HVX74_13750 ENOG4107QMS site-determining protein HVX74_13785 ENOG410658X HVX74_13810 ENOG4105BZU Histidine kinase HVX74_13815 ENOG410738I uncharacterized protein ymgC HVX74_13825 ENOG41077SS Probably a connector protein for RcsB C regulation of biofilm formation, providing additional signal input into the two- component signaling pathway. May serve to stimulate biofilm maturation, probably via the Rcs phosphorelay. Mild overexpression at 16 degrees Celsius increases the production of colanic acid, an exopolysaccharide and matrix component, and reduces adhesive curli fimbriae expression. Both of these effects require RcsB HVX74_13830 ENOG4105WKE Probably a connector protein for RcsB C regulation of biofilm formation, providing additional signal input into the two- component signaling pathway. Partially antagonizes the activities of YmgA and AriR, proteins that, via the Rcs phosphorelay, promote the synthesis of colanic acid, an exopolysaccharide and matrix component HVX74_13835 ENOG4105BZU Histidine kinase HVX74_13840 ENOG4108XDN Transcriptional regulator HVX74_13845 ENOG41064WM Uncharacterized protein YcgX HVX74_13860 ENOG4108HMX isocitrate dehydrogenase (NADP) HVX74_13885 ENOG4107QTF adenylosuccinate lyase HVX74_13890 ENOG4105XJC Two component transcriptional regulator (Winged helix family HVX74_13895 ENOG4105IFJ Histidine kinase HVX74_13900 ENOG4105EZE Cupin 4 family protein HVX74_13910 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HVX74_13920 ENOG4105D38 putrescine abc transporter HVX74_13925 ENOG4107RUE extracellular solute-binding protein family 1 HVX74_13940 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) HVX74_13950 ENOG4105D60 lipoprotein releasing system transmembrane protein HVX74_13955 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) HVX74_13960 ENOG4105D60 lipoprotein releasing system transmembrane protein HVX74_13965 ENOG4105IQC Inner membrane protein YcfT HVX74_13970 ENOG4108JA2 transcriptioN-repair coupling factor HVX74_13975 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein HVX74_13980 ENOG4105RC8 Reduces the permeability of the outer membrane to copper. Seems to be involved in the regulation of biofilm formation. May decrease biofilm formation by repressing cell-cell interaction and cell surface interaction HVX74_13985 ENOG4108IND Tetr family transcriptional regulator HVX74_13990 ENOG4107MBR 17 kDa surface antigen HVX74_13995 ENOG4105CEP NADH dehydrogenase HVX74_14015 ENOG4108WEF Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b) (By similarity) HVX74_14020 ENOG41090DQ Lipoprotein HVX74_14025 ENOG4105K59 histidine triad (HIT) protein HVX74_14030 ENOG4105CNM Receptor HVX74_14035 ENOG4105CI1 PTS System HVX74_14040 ENOG4105F8V Hydrolase, tatD family HVX74_14045 ENOG4107QRG dna polymerase iii HVX74_14055 ENOG4105HHA aminodeoxychorismate lyase HVX74_14060 ENOG4105YAZ 4-amino-4-deoxychorismate lyase HVX74_14065 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) HVX74_14070 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) HVX74_14075 ENOG4105CHR reductase HVX74_14080 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase HVX74_14100 ENOG4105FCQ metal-binding, possibly nucleic acid-binding protein HVX74_14105 ENOG4108UHJ MAF-like protein HVX74_14110 ENOG4105EI2 Pseudouridine synthase HVX74_14115 ENOG4107QQB Ribonuclease E HVX74_14120 ENOG4105DTJ flagellar hook-associated protein HVX74_14125 ENOG4105E1Q flagellar hook-associated protein HVX74_14130 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj HVX74_14145 ENOG4105CGA flagellar basal-body rod protein FlgG HVX74_14150 ENOG4108KPB Flagellar basal-body rod protein FlgF HVX74_14155 ENOG4105BZE flagellar hook protein, FlgE HVX74_14160 ENOG4105W00 Flagellar hook capping protein HVX74_14165 ENOG4108ZC9 flagellar basal-body rod protein flgc HVX74_14170 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) HVX74_14175 ENOG4105CKS Flagella basal body P-ring formation protein flgA HVX74_14180 ENOG4105M9M anti-sigma28 factor FlgM HVX74_14185 ENOG4105QVD Flagella synthesis protein FlgN HVX74_14190 ENOG4105CJR Integral membrane protein (MviN HVX74_14195 ENOG4105EP9 oxidoreductase HVX74_14205 ENOG4105D9U N-acetyltransferase HVX74_14215 ENOG4105E9S glutaredoxin 2 HVX74_14220 ENOG4105F3T (LipO)protein HVX74_14230 ENOG4105MEA DNA damage-inducible protein i HVX74_14235 ENOG4105PVA Biofilm formation regulatory protein BssS HVX74_14240 ENOG4105F76 Sarcosine oxidase HVX74_14245 ENOG4106974 biofilm formation HVX74_14250 ENOG4105DS1 cytochrome b561 HVX74_14255 ENOG4108YYC ycei family HVX74_14265 ENOG4105D1S lipid A biosynthesis HVX74_14275 ENOG4108W47 Acidic protein msyB HVX74_14280 ENOG4105NAC (LipO)protein HVX74_14285 ENOG4105C3A Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs) (By similarity) HVX74_14300 ENOG4107RZC phospholipase d HVX74_14305 ENOG4108UVJ appr-1-p processing domain protein HVX74_14320 ENOG4105G76 Curli are coiled surface structures that assemble preferentially at growth temperatures below 37 degrees Celsius. Curli can bind to fibronectin HVX74_14325 ENOG4108U0V Curli are coiled surface structures that assemble preferentially at growth temperatures below 37 degrees Celsius. Curli can bind to fibronectin. The minor subunit is the nucleation component of curlin monomers HVX74_14330 ENOG41086KC Transcriptional regulator HVX74_14335 ENOG4108XDW curli assembly protein CsgE HVX74_14340 ENOG4108WYR Curli production assembly transport component, CsgF HVX74_14345 ENOG4105P8Q Curli production assembly transport component CsgG HVX74_14350 ENOG4108UQ5 membrane protein YcdZ HVX74_14355 ENOG4107XHZ cytoplasmic chaperone TorD family protein HVX74_14365 ENOG4105JPG D-isomer specific 2-hydroxyacid dehydrogenase HVX74_14375 ENOG4108T85 Membrane HVX74_14420 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) HVX74_14425 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) HVX74_14435 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) HVX74_14445 ENOG41081XD Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) HVX74_14450 ENOG4105D5K Hemolysin activator protein HVX74_14455 ENOG4105CKT filamentous hemagglutinin HVX74_14465 ENOG4105X0I Fimbrial HVX74_14470 ENOG4108AF8 Chaperone HVX74_14475 ENOG4105CW0 outer membrane usher protein HVX74_14485 ENOG4108MQF Chaperone HVX74_14490 ENOG4105CHR reductase HVX74_14495 ENOG4108TC1 Transcriptional regulator HVX74_14505 ENOG4105CXC rtn protein HVX74_14525 ENOG4105D5M phosphate starvation-inducible protein HVX74_14530 ENOG4105DBE peroxidase HVX74_14535 ENOG410650H (LipO)protein HVX74_14550 ENOG4105CK7 Sodium proline symporter HVX74_14555 ENOG4105C26 Dehydrogenase HVX74_14560 ENOG4108R86 Transcriptional regulator HVX74_14595 ENOG4105C2W permease HVX74_14600 ENOG4105XF5 Escherichia coli IMT2125 genomic chromosome, IMT2125 HVX74_14610 ENOG4105XH3 HVX74_14615 ENOG4105D6F Phosphatase HVX74_14635 ENOG4108EM1 reductase HVX74_14640 ENOG4105CUW cytochrome C-TYPE protein HVX74_14645 ENOG4106WF9 DNA-binding transcriptional regulator TorR HVX74_14650 ENOG4108SV3 Tmao reductase system periplasmic protein tort HVX74_14655 ENOG4105BZU Histidine kinase HVX74_14660 ENOG4105HEE Binding Domain protein HVX74_14665 ENOG4106H71 Overexpression increases levels of unsaturated fatty acids and suppresses both the temperature-sensitive fabA6 mutation and cold-sensitive secG null mutation HVX74_14680 ENOG4105VEQ Cold shock protein HVX74_14685 ENOG41060EU Cold shock-like protein HVX74_14695 ENOG4108Y9B (LipO)protein HVX74_14700 ENOG4108W78 Pfam:DUF1017 HVX74_14705 ENOG4105E3R (LipO)protein HVX74_14710 ENOG4105DAY polysaccharide export protein HVX74_14715 ENOG4107ZF2 Phosphatase HVX74_14720 ENOG4108F2G Chain length determinant protein HVX74_14725 ENOG4105D6F Phosphatase HVX74_14735 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii HVX74_14740 ENOG4105C4M (Ubiquinol oxidase) subunit I HVX74_14745 ENOG4105MVP hydrogenase-1 operon protein HyaF HVX74_14750 ENOG4108VXY Hydrogenase-1 operon protein HyaE HVX74_14755 ENOG4108USZ hydrogenase HVX74_14760 ENOG4105X7T Ni Fe-hydrogenase, b-type cytochrome subunit HVX74_14765 ENOG4105DPX Hydrogenase, large subunit HVX74_14770 ENOG4105E3S small subunit HVX74_14780 ENOG4108MN8 Membrane HVX74_14785 ENOG4108Z0T Part of a sulfur-relay system (By similarity) HVX74_14790 ENOG4105VSY K01512 acylphosphatase EC 3.6.1.7 HVX74_14805 ENOG4105K4P CoA-binding domain protein HVX74_14820 ENOG41088T4 Helicase IV HVX74_14825 ENOG410901E Membrane HVX74_14830 ENOG4105EM2 membrane HVX74_14835 ENOG4108RZ1 DNA transformation protein HVX74_14845 ENOG4105UYK outer membrane protein a HVX74_14855 ENOG4105DAN ATP-dependent protease HVX74_14865 ENOG4105WFT During stationary phase, converts 70S ribosomes to an inactive dimeric form (100S ribosomes) (By similarity) HVX74_14870 ENOG4108Q2G (LipO)protein HVX74_14875 ENOG4105DY2 Paraquat-inducible protein b HVX74_14880 ENOG4105F1S paraquat-inducible protein a HVX74_14885 ENOG4105C5H ABC transporter HVX74_14895 ENOG4105QVC MOSC domain-containing protein HVX74_14900 ENOG4108T7E Contributes to the efficiency of the cell division process by stabilizing the polymeric form of the cell division protein FtsZ. Acts by promoting interactions between FtsZ protofilaments and suppressing the GTPase activity of FtsZ (By similarity) HVX74_14910 ENOG4108UZX fmn reductase HVX74_14915 ENOG4105GVF (ABC) transporter HVX74_14925 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component HVX74_14935 ENOG4105CD8 aminopeptidase N HVX74_14950 ENOG4105FCK Membrane HVX74_14955 ENOG4105CGF Aromatic amino acid aminotransferase HVX74_14960 ENOG4105C5X domain protein HVX74_14965 ENOG4105EAQ (twin-arginine translocation) pathway signal HVX74_14970 ENOG4105DIT ErfK YbiS YcfS YnhG family protein HVX74_14980 ENOG4105DAH Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF (By similarity) HVX74_14990 ENOG4106371 Methyltransferase HVX74_14995 ENOG4107S90 membrAne HVX74_15000 ENOG4107VR7 transferase activity, transferring phosphorus-containing groups HVX74_15015 ENOG4105T0Z Conserved Protein HVX74_15025 ENOG4105BZ1 (ABC) transporter HVX74_15030 ENOG4108EQH DNA internalization-related competence protein ComEC Rec2 HVX74_15040 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) HVX74_15050 ENOG4108K0D peptidase, M48 HVX74_15065 ENOG4107VMU Membrane HVX74_15070 ENOG4105DDY UPF0142 protein ycaO HVX74_15075 ENOG4105TMB Formate nitrite transporter HVX74_15080 ENOG4105C6N Formate acetyltransferase HVX74_15085 ENOG4105F1A Pyruvate formate-lyase HVX74_15090 ENOG4105EJG cellulose synthase HVX74_15095 ENOG4107EEX Cellulose synthase regulator protein HVX74_15100 ENOG4107QZ7 Cellulose synthase catalytic subunit HVX74_15105 ENOG41064RH membrane protein YliF HVX74_15110 ENOG4105BZU Histidine kinase HVX74_15115 ENOG4105E5D amino acid HVX74_15125 ENOG4105CHJ isochorismatase hydrolase HVX74_15130 ENOG4107KGK dmso reductase anchor subunit HVX74_15135 ENOG4105QAX Iron-sulfur HVX74_15140 ENOG4107QY8 reductase HVX74_15150 ENOG4105D1H recombination factor protein RarA HVX74_15160 ENOG4105CNU cell division protein FtsK HVX74_15170 ENOG4105C3M thioredoxin reductase HVX74_15175 ENOG4108JJ9 ABC, transporter HVX74_15180 ENOG4108JJ8 (ABC) transporter HVX74_15190 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) HVX74_15200 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit HVX74_15210 ENOG4105VEQ Cold shock protein HVX74_15220 ENOG4105DJY efflux transporter, rnd family, mfp subunit HVX74_15225 ENOG4108MJ5 VirK protein HVX74_15230 ENOG4105CPB ATP-dependent endonuclease of the OLD family HVX74_15235 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) HVX74_15240 ENOG4105DWU Membrane HVX74_15245 ENOG4105EJ7 Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity) HVX74_15250 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) HVX74_15255 ENOG4105C7K acetolactate synthase HVX74_15260 ENOG4105C5W Aldolase HVX74_15265 ENOG4105CGD Nad-dependent epimerase dehydratase HVX74_15270 ENOG4107VBM 3-beta hydroxysteroid dehydrogenase isomerase HVX74_15275 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase HVX74_15285 ENOG41064MM (LipO)protein HVX74_15290 ENOG4105E5Z arginine transporter ATP-binding subunit HVX74_15295 ENOG4106PMH Extracellular solute-binding protein family 3 HVX74_15300 ENOG4105GBT ABC transporter HVX74_15305 ENOG4105DMR ABC, transporter HVX74_15310 ENOG4106TNF Periplasmic binding protein HVX74_15335 ENOG4105RBQ inner membrane protein ybjO HVX74_15340 ENOG4105D38 putrescine abc transporter HVX74_15345 ENOG4105F38 ABC transporter, permease HVX74_15350 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HVX74_15355 ENOG4107RUE extracellular solute-binding protein family 1 HVX74_15360 ENOG4108RMJ sensory transduction regulator HVX74_15370 ENOG4108DBC nitroreductase HVX74_15375 ENOG4105X20 member of the soxRS regulon which mediates in part the increased levels of superoxide in response to oxidative stress HVX74_15380 ENOG41090BQ Glutaredoxin HVX74_15385 ENOG4105GWF inner membrane protein YbjM HVX74_15395 ENOG4108RFG Tetr family transcriptional regulator HVX74_15400 ENOG4106UW1 Major Facilitator superfamily HVX74_15405 ENOG4108HCJ Hydrolase HVX74_15415 ENOG4107QF7 multi-drug HVX74_15420 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase HVX74_15425 ENOG4107FB0 transcriptional regulator DeoR family HVX74_15430 ENOG4105DZ1 carboxypeptidase HVX74_15435 ENOG4108TGY Glutathione S-transferase HVX74_15440 ENOG4105D8V Glucose sorbosone dehydrogenase HVX74_15445 ENOG4105UFT Represses biofilm formation in M9C glu and LB glu media but not in M9C and LB media. Seems to act as a global regulator of several genes involved in catabolite repression and stress response and regulation of the uptake and export of signaling pathways. Could be involved the regulation of indole as well as uptake and export of AI-2 through a cAMP-dependent pathway HVX74_15465 ENOG41064RH membrane protein YliF HVX74_15470 ENOG4105BZU Histidine kinase HVX74_15475 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HVX74_15485 ENOG4105DEF Extracellular solute-binding protein, family 5 HVX74_15495 ENOG4105D44 asparaginase HVX74_15500 ENOG4105CVM Molybdenum cofactor synthesis domain protein HVX74_15505 ENOG4105D06 uba thif-type nad fad binding protein HVX74_15510 ENOG4107T9Z Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) HVX74_15515 ENOG4105F1A Pyruvate formate-lyase HVX74_15525 ENOG4108HCJ Hydrolase HVX74_15530 ENOG4105C5H ABC transporter HVX74_15535 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein HVX74_15540 ENOG4105F4P )-transporter HVX74_15545 ENOG4105KST dependent repressor HVX74_15555 ENOG4108I6E Sulfatase HVX74_15560 ENOG4108T1M outer membrane protein x HVX74_15570 ENOG4107AQZ Membrane HVX74_15580 ENOG4107R0W ABC transporter HVX74_15585 ENOG4105E5Q amino acid AbC transporter HVX74_15590 ENOG4105CDA abc transporter atp-binding protein HVX74_15595 ENOG4105D8X mechanosensitive ion channel HVX74_15605 ENOG4105ZY9 UPF0379 protein ybiM HVX74_15610 ENOG4108IU3 tonb-dependent siderophore receptor HVX74_15620 ENOG4105KSC Transcriptional regulator, TraR DksA family HVX74_15625 ENOG4105VR4 UPF0379 protein ybiJ HVX74_15630 ENOG4105DG4 malate L-lactate dehydrogenase HVX74_15635 ENOG4108MTB glycosyl transferase family HVX74_15640 ENOG4105DVT helicase HVX74_15650 ENOG4105C1J atp-dependent rna helicase HVX74_15655 ENOG4107MVR Transcriptional regulator HVX74_15665 ENOG4105CJ1 ABC, transporter HVX74_15670 ENOG4107QWP ABC-2 type transporter HVX74_15675 ENOG4107QWP ABC-2 type transporter HVX74_15680 ENOG4105I9U inner membrane protein ybhQ HVX74_15685 ENOG4105X23 Endonuclease Exonuclease phosphatase HVX74_15690 ENOG4105DZQ phospholipase D Transphosphatidylase HVX74_15695 ENOG4107UXM Membrane HVX74_15710 ENOG410733J conserved inner membrane protein HVX74_15715 ENOG4105HFZ Membrane HVX74_15720 ENOG4108ZAF Molybdopterin HVX74_15725 ENOG4105M00 molybdopterin converting factor, subunit 1 HVX74_15735 ENOG4108RIR Molybdenum cofactor biosynthesis protein HVX74_15745 ENOG4105CHW UPF0052 protein HVX74_15755 ENOG4105E78 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) HVX74_15760 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) HVX74_15775 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) HVX74_15780 ENOG4108V1U phospholipid-binding protein HVX74_15785 ENOG4105EXC Acyl-transferase HVX74_15900 ENOG4105SZK Rz endopeptidase from lambdoid prophage DLP12 HVX74_15920 ENOG4108R1E Serine threonine protein phosphatase 1 HVX74_15955 ENOG4105NY2 NinB protein HVX74_15975 ENOG4105CDU Replicative dna helicase HVX74_16115 ENOG4108I1J Integrase HVX74_16120 ENOG4105NBR Pectinesterase HVX74_16125 ENOG4107QM5 aconitate hydratase HVX74_16130 ENOG4107QPK )-transporter HVX74_16135 ENOG4105C7F AcnD-accessory protein PrpF HVX74_16140 ENOG4105F04 LysR family Transcriptional regulator HVX74_16150 ENOG4108K4B hydrolase HVX74_16155 ENOG4105CGB Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system (By similarity) HVX74_16160 ENOG4105E0C molybdate abc transporter HVX74_16165 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein HVX74_16175 ENOG4105F4R Transcriptional regulator mode HVX74_16180 ENOG4105DKW ABC transporter HVX74_16185 ENOG4105CMR udp-glucose 4-epimerase HVX74_16190 ENOG4105F0Z galactose-1-phosphate uridylyltransferase HVX74_16200 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) HVX74_16210 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) HVX74_16215 ENOG4105JND homeobox protein HVX74_16220 ENOG4105PGM cation diffusion facilitator family transporter HVX74_16225 ENOG4106Z1T Nicotinamide Mononucleotide Transporter HVX74_16230 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) HVX74_16275 ENOG4105UFD tol-pal system protein YbgF HVX74_16280 ENOG4105KCK Peptidoglycan-associated lipoprotein HVX74_16290 ENOG4108Z82 Cell envelope integrity inner membrane protein TolA HVX74_16300 ENOG4105E02 MotA TolQ exbB proton channel HVX74_16305 ENOG4107YD3 Thioesterase HVX74_16310 ENOG4105KJB cyd operon protein YbgE HVX74_16320 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii HVX74_16325 ENOG4105C4M (Ubiquinol oxidase) subunit I HVX74_16340 ENOG4107WFU Glutamate mutase subunit sigma HVX74_16350 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha HVX74_16360 ENOG4105C7S Dehydrogenase HVX74_16365 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 HVX74_16370 ENOG4105E33 succinate dehydrogenase HVX74_16375 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) HVX74_16380 ENOG4105N1I succinate dehydrogenase, hydrophobic membrane anchor protein HVX74_16385 ENOG4108UTY succinate dehydrogenase, cytochrome b556 subunit HVX74_16395 ENOG4105BZN citrate synthase HVX74_16400 ENOG4105CG6 trap dicarboxylate transporter dctm subunit HVX74_16410 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit HVX74_16415 ENOG4105CTX dehydratase HVX74_16425 ENOG4105CHR reductase HVX74_16430 ENOG4105CPQ Dehydrogenase HVX74_16435 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) HVX74_16440 ENOG41073TP transcriptional regulator HVX74_16445 ENOG4108KK1 membrane protein AbrB duplication HVX74_16450 ENOG4108S0J Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized pyrimidines, such as thymine glycol, 5,6-dihydrouracil and 5,6-dihydrothymine. Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'- phosphates (By similarity) HVX74_16455 ENOG4105E7W lamb ycsf family protein HVX74_16460 ENOG4107R7A Allophanate hydrolase subunit 2 HVX74_16465 ENOG4105P4J Allophanate hydrolase, subunit 1 HVX74_16470 ENOG4107QNR UPF0135 protein HVX74_16475 ENOG4105DUX Transporter HVX74_16480 ENOG4105CVP deoxyribo-dipyrimidine photolyase HVX74_16485 ENOG4107SEY Conserved Protein HVX74_16505 ENOG4105CNA YD repeat protein HVX74_16515 ENOG4105XIQ Protein of unknown function (DUF2517) HVX74_16540 ENOG4105C08 Histidine kinase HVX74_16545 ENOG4105EEX Two component transcriptional regulator (Winged helix family HVX74_16550 ENOG4107QIX Phosphoglucomutase (EC 5.4.2.2 HVX74_16555 ENOG4107CDU Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated (By similarity) HVX74_16560 ENOG4105EV9 Alpha Beta Hydrolase HVX74_16565 ENOG4105NNH LexA regulated protein HVX74_16570 ENOG4105MHQ Low-potential electron donor to a number of redox enzymes (By similarity) HVX74_16580 ENOG41090R7 Ferric uptake HVX74_16585 ENOG4105GX6 (LipO)protein HVX74_16600 ENOG4105CI1 PTS System HVX74_16610 ENOG4105CE4 GlcNAc 6-P deacetylase HVX74_16615 ENOG4105E2R ROK family HVX74_16620 ENOG4105D4U had-superfamily hydrolase, subfamily iia HVX74_16625 ENOG4105CAQ asparagine synthetase HVX74_16670 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family HVX74_16680 ENOG4105C9A Phoh family HVX74_16690 ENOG4108JU5 Magnesium and cobalt efflux protein HVX74_16695 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) HVX74_16700 ENOG4107RP9 extracellular solute-binding protein, family 3 HVX74_16705 ENOG4105EAD ABC transporter HVX74_16710 ENOG4105DRP amino acid AbC transporter HVX74_16715 ENOG4105CDA abc transporter atp-binding protein HVX74_16725 ENOG4105F7F Chaperone HVX74_16730 ENOG4105QFC Hsc56 co-chaperone of HscC HVX74_16735 ENOG41069CF Protein of unknown function (DUF1266) HVX74_16740 ENOG4107JFD Sel1 repeat HVX74_16745 ENOG4105QFC Hsc56 co-chaperone of HscC HVX74_16750 ENOG41069CF Protein of unknown function (DUF1266) HVX74_16755 ENOG4105EUU Sel1 domain protein repeat-containing protein HVX74_16760 ENOG4107PAI alpha helical protein HVX74_16775 ENOG4105DJF DNA polymerase III, delta' subunit HVX74_16785 ENOG4108TGR phosphatase HVX74_16790 ENOG4105KEM Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) HVX74_16800 ENOG4105CJN penicillin-binding protein HVX74_16805 ENOG4105CNI cell division protein FtsW HVX74_16810 ENOG4105K6T rare lipoprotein A HVX74_16815 ENOG4105DZ1 carboxypeptidase HVX74_16840 ENOG410607N Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatE shares overlapping functions with TatA (By similarity) HVX74_16860 ENOG41079UR PagP is required both for biosynthesis of hepta-acylated lipid A species containing palmitate and for resistance to cationic antimicrobial peptides (CAMPs). It catalyzes the transfer of a palmitate chain (16 0) from the sn-1 position of a glycerophospholipid to the free hydroxyl group of the (R)-3- hydroxymyristate chain at position 2 of lipid A (endotoxin) (By similarity) HVX74_16865 ENOG4105CEE C4-dicarboxylate transporter HVX74_16870 ENOG4106YYS transcriptional regulatory protein HVX74_16875 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism HVX74_16880 ENOG4105DUA (citrate (pro-3S)-lyase ligase HVX74_16890 ENOG4105CI0 Citrate lyase HVX74_16895 ENOG4105CHY citrate lyase, alpha HVX74_16910 ENOG4107QPK )-transporter HVX74_16915 ENOG4105KTS ribonuclease HVX74_16920 ENOG4105NXH GreA GreB family elongation factor HVX74_16925 ENOG4105E2A Dehydrogenase HVX74_16930 ENOG4108U51 Universal stress protein HVX74_16935 ENOG4108JU3 Alkyl hydroperoxide reductase HVX74_16940 ENOG4105D3R alkyl hydroperoxide reductase HVX74_16945 ENOG4108KHN disulfide isomerase, thiol-disulfide oxidase HVX74_16950 ENOG4105DQS Transcriptional regulator HVX74_16955 ENOG4105BZV Phosphoadenosine phosphosulfate reductase HVX74_16960 ENOG4105GTN ParB Domain Protein Nuclease HVX74_16965 ENOG4105CHM Aminotransferase HVX74_16970 ENOG4107SCQ Iron-containing alcohol dehydrogenase HVX74_16975 ENOG4105VCD cytoplasmic protein HVX74_16980 ENOG4105D22 carbon starvation protein HVX74_16985 ENOG4108TZA Required for optimal enterobactin synthesis. Acts as a proofreading enzyme that prevents EntB misacylation by hydrolyzing the thioester bound existing between EntB and wrongly charged molecules (By similarity) HVX74_16990 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase HVX74_16995 ENOG4105WQI isochorismatase HVX74_17000 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase HVX74_17005 ENOG4105E4F Isochorismate synthase HVX74_17010 ENOG4105PEC Iron-enterobactin transporter periplasmic binding protein HVX74_17020 ENOG4105DQ5 transport system permease protein HVX74_17025 ENOG4105TVJ transport system, permease HVX74_17030 ENOG4105E0A ABC, transporter HVX74_17035 ENOG4108QY5 Ferric enterobactin transport protein HVX74_17040 ENOG4105C0W non-ribosomal peptide synthetase HVX74_17045 ENOG41085A6 mbth domain-containing protein HVX74_17050 ENOG4105E93 esterase HVX74_17055 ENOG4107RNH Outer membrane receptor FepA HVX74_17060 ENOG4108TSE Transferase HVX74_17080 ENOG4105WQ6 Membrane HVX74_17085 ENOG4105MSB protein, conserved in bacteria HVX74_17090 ENOG4108RCM Nitroreductase HVX74_17095 ENOG4105CUY Mechanosensitive ion channel HVX74_17100 ENOG4105C85 amino acid HVX74_17105 ENOG4108IJF Heavy metal efflux pump, CzcA HVX74_17110 ENOG4105EP1 Efflux transporter rnd family, mfp subunit HVX74_17115 ENOG410624V efflux system protein HVX74_17120 ENOG4105ENJ RND efflux system, outer membrane lipoprotein HVX74_17125 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HVX74_17130 ENOG4105GR3 Histidine kinase HVX74_17135 ENOG410802X bacteriophage n4 adsorption protein b HVX74_17140 ENOG41090FC Bacteriophage N4 receptor, outer membrane subunit HVX74_17145 ENOG4105QUW HVX74_17150 ENOG4108NC2 Outer membrane protease HVX74_17155 ENOG4108WF3 methyltransferase HVX74_17180 ENOG4105WQ3 Rna-binding protein HVX74_17185 ENOG4105S2T inner membrane protein YbcI HVX74_17195 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) HVX74_17205 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) HVX74_17210 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit HVX74_17215 ENOG4105C5B carbamate kinase HVX74_17220 ENOG4105G5A Protein of unknown function (DUF2877) HVX74_17225 ENOG4107REC cytoplasmic protein HVX74_17230 ENOG4107R1Q Membrane protein FdrA HVX74_17235 ENOG4105DG4 malate L-lactate dehydrogenase HVX74_17240 ENOG4105CE7 Amidase, hydantoinase carbamoylase family HVX74_17245 ENOG4105S0E allantoin catabolism protein HVX74_17250 ENOG4105BZW Glycerate kinase HVX74_17255 ENOG4105DTE Xanthine uracil vitamin C permease HVX74_17260 ENOG4105CD3 dihydroorotase HVX74_17265 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease HVX74_17270 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase HVX74_17275 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) HVX74_17280 ENOG41060W2 glyoxylate carboligase HVX74_17285 ENOG4108N16 Negative regulator of allantoin and glyoxylate utilization operons. Binds to the gcl promoter and to the allS- allA intergenic region HVX74_17295 ENOG4107653 Transcriptional regulator HVX74_17305 ENOG4105CV6 ABC transporter, permease HVX74_17310 ENOG4108I0Y (ABC) transporter HVX74_17315 ENOG4108UJV acyl-CoA thioesterase i HVX74_17320 ENOG4105E1F short-chain dehydrogenase reductase HVX74_17325 ENOG4107QR8 Thioredoxin HVX74_17330 ENOG4105C4B ABC transporter, permease HVX74_17335 ENOG41083J0 (ABC) transporter HVX74_17340 ENOG4107QX8 SPFH domain, Band 7 family protein HVX74_17345 ENOG4105G5H Membrane HVX74_17365 ENOG4108Z6Z Transcriptional regulator HVX74_17370 ENOG4107QZV Type I secretion membrane fusion protein HVX74_17390 ENOG4107RY6 amino acid HVX74_17395 ENOG4105CSV Glutaminase HVX74_17400 ENOG4105C59 p-type ATPase HVX74_17405 ENOG4105MBR gumn family HVX74_17410 ENOG4108Z66 YbaK ebsC protein HVX74_17415 ENOG4105CGH 5'-nucleotidase HVX74_17420 ENOG4105EU0 Major facilitator Superfamily HVX74_17425 ENOG4105CKD glutathione-regulated potassium-efflux system protein HVX74_17430 ENOG4107RE1 Inosine-guanosine kinase HVX74_17465 ENOG4107QMP dna polymerase iii subunits gamma and tau HVX74_17475 ENOG4105WD1 Membrane HVX74_17480 ENOG4108URS primosomal replication protein n'' HVX74_17485 ENOG4106428 Protein of unknown function (DUF2496) HVX74_17490 ENOG4105EGS Mechanosensitive ion channel HVX74_17495 ENOG4107XI7 Tetr family transcriptional regulator HVX74_17500 ENOG4105C1P efflux transporter, rnd family, mfp subunit HVX74_17505 ENOG4105BZS acriflavin resistance protein HVX74_17510 ENOG4108UKR Biofilm formation regulator YbaJ HVX74_17515 ENOG4105KF5 hemolysin expression-modulating protein HVX74_17520 ENOG4108UW5 maltose o-acetyltransferase HVX74_17525 ENOG4105GSJ Inner membrane protein ylaC HVX74_17530 ENOG41066DG (EAL) domain protein HVX74_17535 ENOG4105KCV RNA signal recognition particle 4.5S RNA HVX74_17545 ENOG41080UX Methyltransferase HVX74_17550 ENOG4108MNP Glycoprotein polysaccharide metabolism HVX74_17555 ENOG4105C29 acyl-CoA thioesterase HVX74_17560 ENOG4105BZU Histidine kinase HVX74_17565 ENOG4108YZA Nitrogen regulatory protein pii HVX74_17570 ENOG4105BZ1 (ABC) transporter HVX74_17575 ENOG4105BZ1 (ABC) transporter HVX74_17580 ENOG4108XM1 transcriptional regulator AsnC family HVX74_17585 ENOG4108AZI Catalyzes the hydrolysis of 4-amino-2-methyl-5- hydroxymethylpyrimidine pyrophosphate (HMP-PP) to 4-amino-2- methyl-5-hydroxymethylpyrimidine phosphate (HMP-P) (By similarity) HVX74_17590 ENOG4108NFA extracellular solute-binding protein HVX74_17600 ENOG4108TGP Thioesterase superfamily protein HVX74_17605 ENOG41083P1 competence protein ComEA helix-hairpin-helix repeat protein HVX74_17610 ENOG4105EIN peptidylprolyl cis-trans isomerase HVX74_17615 ENOG4105K70 DNA-binding protein HVX74_17620 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) HVX74_17640 ENOG4105M85 Bola protein HVX74_17645 ENOG4105IEY (LipO)protein HVX74_17650 ENOG4105EYM Major Facilitator superfamily HVX74_17655 ENOG4105E2S oxidase) subunit II HVX74_17660 ENOG4105BZ9 Cytochrome C oxidase, subunit I HVX74_17665 ENOG4105CCU oxidase (Subunit III) HVX74_17670 ENOG41090KH cytochrome o ubiquinol oxidase (subunit iv) HVX74_17680 ENOG4107RDB Major Facilitator HVX74_17690 ENOG4108JZF Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) HVX74_17695 ENOG4107S0N DJ-1 family HVX74_17710 ENOG4105CTB Polyprenyl synthetase HVX74_17720 ENOG4105CPC Aldo Keto reductase HVX74_17730 ENOG4108ZAI phosphatidylglycerophosphatase a HVX74_17735 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) HVX74_17745 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) HVX74_17750 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) HVX74_17760 ENOG4108KIC (LipO)protein HVX74_17765 ENOG4105DRB nucleoside-specific channel-forming protein HVX74_17770 ENOG4105N1F Hnh endonuclease HVX74_17775 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) HVX74_17780 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) HVX74_17785 ENOG4105VIE preprotein translocase, subunit YajC HVX74_17795 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) HVX74_17805 ENOG4107R28 alpha amylase, catalytic region HVX74_17810 ENOG4105C85 amino acid HVX74_17815 ENOG4105CWM branched-chain amino acid transport system II carrier protein HVX74_17820 ENOG4105BZU Histidine kinase HVX74_17825 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HVX74_17830 ENOG4107RH8 nuclease SbcCD subunit D HVX74_17835 ENOG4105EYH Exonuclease HVX74_17840 ENOG4105F27 Major Facilitator HVX74_17845 ENOG4105DKQ ROK family HVX74_17870 ENOG4105HBA AroM protein HVX74_17875 ENOG4105SS3 HVX74_17890 ENOG4105II7 pyrroline-5-carboxylate reductase HVX74_17895 ENOG4105BZU Histidine kinase HVX74_17900 ENOG4105VIF phosphate starvation-inducible protein HVX74_17905 ENOG4105G6Z alkaline phosphatase HVX74_17920 ENOG4105CPF Cell wall formation (By similarity) HVX74_17925 ENOG4105UNH Membrane HVX74_17930 ENOG4105FR5 inner membrane protein YaiY HVX74_17935 ENOG4107QS8 (LipO)protein HVX74_17940 ENOG4108DQG in Escherichia coli SbmA is involved in uptake of microcin J25 HVX74_17945 ENOG4107R6D beta-lactam binding protein AmpH HVX74_17950 ENOG4108PNB DNA-binding transcriptional regulator HVX74_17960 ENOG4105D52 delta-aminolevulinic acid dehydratase HVX74_17965 ENOG4105E2B Taurine dioxygenase HVX74_17970 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component HVX74_17975 ENOG4108IY8 ABC, transporter HVX74_17980 ENOG4106FTQ Taurine ABC transporter, periplasmic HVX74_17990 ENOG4108PBI Polysaccharide metabolism HVX74_18000 ENOG4105SRB Uncharacterized protein yaiO HVX74_18020 ENOG4105IUQ nucleoprotein polynucleotide-associated enzyme HVX74_18025 ENOG4108SC4 )-transporter HVX74_18060 ENOG4108K2P TRANSCRIPTIONal HVX74_18065 ENOG4105ETE Transcriptional regulator (LacI family HVX74_18075 ENOG4105U0F oligosaccharide H symporter, major facilitator superfamily (MFS) HVX74_18080 ENOG4108UW5 maltose o-acetyltransferase HVX74_18085 ENOG4105DJ2 Major Facilitator Superfamily HVX74_18095 ENOG4107B2H carbonic anhydrase HVX74_18100 ENOG4105DND Transcriptional regulator HVX74_18105 ENOG4105DZC cytosine deaminase HVX74_18110 ENOG4105DQW permease for cytosine purines, uracil, thiamine, allantoin HVX74_18115 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) HVX74_18120 ENOG4105DXD 2-methylcitrate dehydratase HVX74_18125 ENOG4105BZN citrate synthase HVX74_18130 ENOG4105CR4 methylisocitrate lyase HVX74_18135 ENOG4108JU7 Transcriptional regulator HVX74_18140 ENOG4105TDT uncharacterized protein yahO HVX74_18145 ENOG4105E82 cytochrome subunit of dehydrogenase HVX74_18160 ENOG4105DQ4 alcohol dehydrogenase HVX74_18165 ENOG4105CNN ABC, transporter HVX74_18170 ENOG4105CNN ABC, transporter HVX74_18175 ENOG4105C2J ABC transporter HVX74_18180 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator HVX74_18190 ENOG4105DZC cytosine deaminase HVX74_18195 ENOG4105C5B carbamate kinase HVX74_18200 ENOG4107REC cytoplasmic protein HVX74_18205 ENOG4107R1Q Membrane protein FdrA HVX74_18210 ENOG4105N16 Protein of unknown function (DUF2877) HVX74_18215 ENOG4107SNB ankyrin repeat protein YahD HVX74_18220 ENOG4105SZ2 membrAne HVX74_18225 ENOG4108NUU Transcriptional regulator HVX74_18230 ENOG4105BZU Histidine kinase HVX74_18240 ENOG4105C94 Transporter HVX74_18260 ENOG4108W9T type 1 fimbriae regulatory protein HVX74_18265 ENOG4105BZU Histidine kinase HVX74_18290 ENOG4108ZZK Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source (By similarity) HVX74_18295 ENOG4107QR9 Iron-sulfur cluster binding protein HVX74_18300 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) HVX74_18305 ENOG4108K01 transcriptional regulator HVX74_18310 ENOG4107QN2 dihydrolipoyl dehydrogenase HVX74_18315 ENOG41066GK UPF0379 protein ykgI HVX74_18320 ENOG4108KBJ Inner membrane protein YkgB HVX74_18325 ENOG4105CV8 reductase HVX74_18345 ENOG4105EQ2 LysR family Transcriptional regulator HVX74_18395 ENOG4106PYX Receptor HVX74_18405 ENOG4105PI0 Ferredoxin HVX74_18410 ENOG4105R3P Inner membrane protein yagU HVX74_18415 ENOG4107XKX isoquinoline 1-oxidoreductase, alpha subunit HVX74_18420 ENOG4105DIP Molybdopterin dehydrogenase FAD-binding HVX74_18425 ENOG4105C7W Xanthine dehydrogenase HVX74_18430 ENOG4107XAN XdhC and CoxI family HVX74_18435 ENOG4107RTG Major Facilitator superfamily HVX74_18440 ENOG4105ENX hydrolase HVX74_18445 ENOG4105EQ2 LysR family Transcriptional regulator HVX74_18455 ENOG4105EMU Dehydrogenase HVX74_18480 ENOG4108C33 Resolvase HVX74_18490 ENOG4105PTU response to oxidative stress HVX74_18495 ENOG4108US3 tail fiber assembly HVX74_18500 ENOG4105Y9F tail fiber protein HVX74_18505 ENOG4105Y0G tail protein HVX74_18510 ENOG4108T86 baseplate J family protein HVX74_18530 ENOG4108NKR DNA circulation protein HVX74_18550 ENOG4105TKZ Tail Sheath HVX74_18595 ENOG4105EFC phage portal protein HK97 family HVX74_18605 ENOG4105CAR Terminase, large subunit HVX74_18660 ENOG4105RWQ Protein of unknown function (DUF1364) HVX74_18665 ENOG410757E Protein NinE homolog from lambdoid prophage DLP12 HVX74_18670 ENOG4108V2F protein ybcN in lambdoid DLP12 prophage regi HVX74_18690 ENOG4107TII Recombinase HVX74_18700 ENOG410814C multidrug resistance protein HVX74_18785 ENOG4108KU3 Integrase HVX74_18795 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) HVX74_18805 ENOG4105FCK Membrane HVX74_18815 ENOG4105V1F Fermentation respiration switch protein HVX74_18825 ENOG4105CIN aminoacyl-histidine dipeptidase HVX74_18830 ENOG4108S2Y peptide Chain Release factor HVX74_18840 ENOG4108HYG acetyltransferase HVX74_18860 ENOG4108UK5 Transposase HVX74_18865 ENOG4108YS0 lipoprotein YafL HVX74_18870 ENOG4105F7V ErfK ybiS ycfS ynhG family protein HVX74_18875 ENOG4105E7A Glutamine amidotransferase HVX74_18885 ENOG4107QPN acyl-Coa dehydrogenase HVX74_18890 ENOG4108WN0 inhibitor of vertebrate lysozyme HVX74_18895 ENOG4105CZ7 nitrilase cyanide hydratase and apolipoprotein n-acyltransferase HVX74_18925 ENOG4105CNA YD repeat protein HVX74_18950 ENOG410600T transposase HVX74_18975 ENOG41090EK ompa motb domain protein HVX74_19010 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit HVX74_19050 ENOG4107RZZ dna polymerase iii epsilon subunit HVX74_19060 ENOG4105D1A Methyltransferase HVX74_19070 ENOG4105E9H Lytic Murein transglycosylase HVX74_19075 ENOG4105F2W methyltransferase HVX74_19085 ENOG4105HEI LysR family (Transcriptional regulator HVX74_19090 ENOG4105CV8 reductase HVX74_19125 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase HVX74_19130 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) HVX74_19135 ENOG4108UMI ABC transporter, permease HVX74_19140 ENOG4105D01 (LipO)protein HVX74_19145 ENOG4108R8X outer membrane lipoprotein HVX74_19150 ENOG4108R96 Methyltransferase, YaeB family HVX74_19160 ENOG4108UY0 (LipO)protein HVX74_19165 ENOG4107EII Lipoprotein involved with copper homeostasis and adhesion HVX74_19170 ENOG4108YZN class I peptide chain release factor HVX74_19175 ENOG4108VWS Yaeq family HVX74_19185 ENOG4105M1T rho-binding antiterminator HVX74_19190 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) HVX74_19195 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase HVX74_19200 ENOG4105CXN decarboxylase HVX74_19210 ENOG4105C0B DNA polymerase III (alpha subunit) HVX74_19220 ENOG4105D0V Condensation of UDP-2,3-diacylglucosamine and 2,3- diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) HVX74_19235 ENOG4105D7M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) HVX74_19240 ENOG4108RFI Molecular chaperone that interacts specifically with outer membrane proteins, thus maintaining the solubility of early folding intermediates during passage through the periplasm (By similarity) HVX74_19250 ENOG4105DZP Membrane-associated zinc metalloprotease HVX74_19255 ENOG4105KNE Phosphatidate cytidylyltransferase HVX74_19260 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) HVX74_19265 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) HVX74_19290 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) HVX74_19310 ENOG4108IXP Carbohydrate diacid transcriptional activator CdaR HVX74_19315 ENOG4105C0H protease HVX74_19330 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) HVX74_19335 ENOG4105EN6 Membrane HVX74_19360 ENOG4105S6R Iron-hydroxamate transporter permease subunit HVX74_19365 ENOG4105J76 Periplasmic binding protein HVX74_19370 ENOG4105E0A ABC, transporter HVX74_19375 ENOG4105E0K tonB-dependent siderophore receptor HVX74_19380 ENOG4105BZ4 penicillin-binding protein HVX74_19385 ENOG4105CQ7 ATP-dependent helicase HVX74_19390 ENOG4107XID 2'-5' rna ligase HVX74_19410 ENOG4105DJ0 Poly(A) Polymerase HVX74_19415 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase HVX74_19425 ENOG4108VEV chaperone HVX74_19430 ENOG4105CW0 outer membrane usher protein HVX74_19435 ENOG4108XEY fimbrial-like adhesin protein HVX74_19440 ENOG4105SYG Fimbrial protein HVX74_19445 ENOG4105SN2 fimbrial-like adhesin protein HVX74_19460 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) HVX74_19465 ENOG4108A32 Transposase HVX74_19475 ENOG4107BJW polysaccharide deacetylase HVX74_19480 ENOG4108YTN IIa component HVX74_19485 ENOG4105E3A (ABC) transporter HVX74_19490 ENOG4105DA5 (ABC) transporter HVX74_19495 ENOG41077A9 carbonic anhydrase HVX74_19500 ENOG4108UGV hypoxanthine phosphoribosyltransferase HVX74_19505 ENOG4105DZG Dehydrogenase HVX74_19510 ENOG4105E3B Multicopper oxidase HVX74_19515 ENOG4108ZRK uncharacterized protein yacC HVX74_19535 ENOG4107QIJ Aconitate hydratase 2 HVX74_19540 ENOG4108NST exported protein HVX74_19545 ENOG4107QN2 dihydrolipoyl dehydrogenase HVX74_19550 ENOG4107QSN dihydrolipoamide acetyltransferase HVX74_19555 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) HVX74_19560 ENOG41073TP transcriptional regulator HVX74_19565 ENOG4105C85 amino acid HVX74_19570 ENOG4106A72 regulatory protein AmpE HVX74_19575 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase HVX74_19580 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase HVX74_19585 ENOG4108ZUW Major pilin subunit HVX74_19590 ENOG4107QHF type ii secretion system protein e HVX74_19595 ENOG4105D7Q type ii secretion system HVX74_19610 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) HVX74_19625 ENOG4105M6F mutator MutT protein HVX74_19645 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) HVX74_19650 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) HVX74_19655 ENOG4105K7E Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity) HVX74_19660 ENOG4105CPF Cell wall formation (By similarity) HVX74_19675 ENOG4105CNI cell division protein FtsW HVX74_19680 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) HVX74_19690 ENOG4108EQQ Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity) HVX74_19695 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) HVX74_19700 ENOG4105CJN penicillin-binding protein HVX74_19705 ENOG41063Y6 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) HVX74_19720 ENOG4107B7Y DNA-binding transcriptional regulator FruR HVX74_19730 ENOG4108ZP8 Acetolactate synthase small subunit HVX74_19735 ENOG4105C7K acetolactate synthase HVX74_19745 ENOG41064T2 transcriptional regulator, lysR family HVX74_19785 ENOG4105DP9 ABC transporter HVX74_19790 ENOG4106SMU thiamine transporter membrane protein HVX74_19800 ENOG4108KF1 Membrane HVX74_19805 ENOG41063TF transcriptional regulator (AraC HVX74_19820 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase HVX74_19825 ENOG4105CQ2 DNA polymerase HVX74_19830 ENOG4105BZK Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair (By similarity) HVX74_19835 ENOG4105D3G Pseudouridine synthase HVX74_19840 ENOG41066UG Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host (By similarity) HVX74_19845 ENOG4105E7H involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity) HVX74_19850 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) HVX74_19885 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) HVX74_19900 ENOG4105C54 Major Facilitator superfamily HVX74_19905 ENOG4105IBM Could be part of an electron transfer system required for anaerobic carnitine reduction. Could be a 3Fe-4S cluster- containing protein HVX74_19910 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase HVX74_19915 ENOG4105C10 Electron transfer flavoprotein HVX74_19925 ENOG4105C94 Transporter HVX74_19945 ENOG4106YT9 Enoyl-CoA hydratase HVX74_19955 ENOG4108XNW Transcriptional activatory protein CaiF HVX74_19960 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain HVX74_19965 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain HVX74_19985 ENOG41090X3 Peptidyl-prolyl cis-trans isomerase HVX74_20000 ENOG4105DTN riboflavin biosynthesis protein ribF HVX74_20005 ENOG410647N response to DNA damage stimulus HVX74_20015 ENOG41063Z6 transcriptional regulator, lysR family HVX74_20030 ENOG41061MV Arylsulfatase HVX74_20040 ENOG4105WI6 cell killing protein encoded within cryptic prophage HVX74_20060 ENOG4108QUJ UPF0174 protein YaaW HVX74_20065 ENOG4106HK8 GPR1 FUN34 yaaH family protein HVX74_20070 ENOG4108RIR Molybdenum cofactor biosynthesis protein HVX74_20080 ENOG4105BZG amino acid carrier protein HVX74_20090 ENOG41062C6 Protein of unknown function (DUF2502) HVX74_20095 ENOG4105D98 threonine synthase HVX74_20105 ENOG4105CFH Aspartokinase HVX74_20115 ENOG4106FVC RNA methyltransferase HVX74_20120 ENOG410759A HVX74_20125 ENOG41065U4 response regulator HVX74_20130 ENOG4105CT7 inner membrane cred family protein HVX74_20135 ENOG4105EB3 Histidine kinase HVX74_20140 ENOG4105E3W Two component transcriptional regulator (Winged helix family HVX74_20145 ENOG4108RH0 Crea protein HVX74_20150 ENOG4105UEI Transcriptional Regulator AraC Family HVX74_20160 ENOG4108K16 Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) HVX74_20170 ENOG4107SC1 transglycosylase HVX74_20175 ENOG4105C5H ABC transporter HVX74_20180 ENOG4107RSM transcriptional regulator HVX74_20190 ENOG4105EWI Short-chain dehydrogenase reductase Sdr HVX74_20205 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HVX74_20210 ENOG41090VV Protein of unknown function (DUF2846) HVX74_20220 ENOG4107VZS Nicotinamide-nucleotide adenylyltransferase HVX74_20225 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) HVX74_20230 ENOG4105EAC phosphoserine phosphatase HVX74_20235 ENOG41062Z9 Membrane HVX74_20250 ENOG4105D3A purine nucleoside phosphorylase DeoD-type HVX74_20265 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) HVX74_20270 ENOG4105G0K glycine radical enzyme YjjI family HVX74_20275 ENOG41076CZ activating enzyme HVX74_20280 ENOG4105EYA deoxyribonuclease HVX74_20285 ENOG4108NRW Phospholipase, patatin family HVX74_20295 ENOG4105K3G Periplasmic Protein HVX74_20305 ENOG4105PAD Hydrolase HVX74_20310 ENOG4105KEG ribosomal-protein-alanine acetyltransferase HVX74_20315 ENOG4108WPU DNA polymerase III subunit psi HVX74_20340 ENOG4105YBH Protein of unknown function (DUF1435) HVX74_20345 ENOG4108819 ferric iron reductase HVX74_20350 ENOG4108T94 DNA-binding transcriptional activator BglJ HVX74_20355 ENOG4108N8T regulatoR HVX74_20360 ENOG4105DWK Membrane HVX74_20375 ENOG4106CVF DNA replication protein HVX74_20380 ENOG4105RI1 glycoprotein receptor HVX74_20390 ENOG4105CPQ Dehydrogenase HVX74_20395 ENOG410617M Transcriptional regulator HVX74_20400 ENOG4108I5G Major Facilitator superfamily HVX74_20405 ENOG4105C8Q Methyl-accepting chemotaxis HVX74_20410 ENOG4105D22 carbon starvation protein HVX74_20415 ENOG4105VCD cytoplasmic protein HVX74_20420 ENOG4105CKI cobalamin synthesis protein HVX74_20425 ENOG4106H3A restriction HVX74_20430 ENOG4107SCJ type I restriction enzyme EcoKI subunit R HVX74_20435 ENOG4105CVR type I restriction-modification system HVX74_20450 ENOG4105FBQ ATPase associated with various cellular activities aaa_5 HVX74_20455 ENOG4107SQC 5-methylcytosine-specific restriction enzyme subunit McrC HVX74_20465 ENOG4108YUH HVX74_20470 ENOG4106DIZ Domain of unknown function (DUF1127) HVX74_20475 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HVX74_20485 ENOG41083G8 Multidrug resistance protein MdtM HVX74_20490 ENOG4106BRA Membrane HVX74_20495 ENOG4105DCU 2-hydroxyglutaryl-CoA dehydratase HVX74_20500 ENOG4105CIZ coA-substrate-specific enzyme activase HVX74_20515 ENOG4108ZK4 sdia-regulated domain-containing protein HVX74_20520 ENOG4105CBP Major Facilitator HVX74_20535 ENOG41074DU domain protein HVX74_20540 ENOG4108P2H Inner membrane protein YjiG HVX74_20545 ENOG4105DYB Isoaspartyl dipeptidase HVX74_20550 ENOG4107YNJ LysR family Transcriptional regulator HVX74_20565 ENOG4105C6F GntR Family Transcriptional Regulator HVX74_20570 ENOG4105DEI Mannitol dehydrogenase HVX74_20580 ENOG4107EFN gluconate transport system permease 3 HVX74_20585 ENOG410643X FIMH SUBUNIT MANNOSE-sensitive type 1 fimbrial adhesin HVX74_20590 ENOG4108T65 Fimbrial HVX74_20595 ENOG4108SQA Fimbrial HVX74_20600 ENOG4105CW0 outer membrane usher protein HVX74_20605 ENOG4108NAE Fimbrial chaperone protein HVX74_20610 ENOG4108S54 Fimbrial protein HVX74_20615 ENOG4108RQP Major type 1 subunit fimbrin HVX74_20620 ENOG4105E71 FimE is one of the 2 regulatory proteins which control the phase variation of type 1 fimbriae in E.coli. These proteins mediate the periodic inversion of a 300bp DNA segment that harbors the promoter for the fimbrial structural gene, fimA. FimE switches fimA off HVX74_20625 ENOG4108W9T type 1 fimbriae regulatory protein HVX74_20630 ENOG41069FU Outer membrane channel protein allowing the entry of N- acetylneuraminic acid (Neu5Ac, the most abundant sialic acid on host cell surfaces) into the bacteria HVX74_20670 ENOG4105DQ4 alcohol dehydrogenase HVX74_20675 ENOG4105D7A ATP-binding protein HVX74_20680 ENOG4108K5H permease YjgP YjgQ family protein HVX74_20685 ENOG4108M8S permease YjgP YjgQ family protein HVX74_20695 ENOG4105MYG DNA polymerase iii, chi subunit HVX74_20700 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) HVX74_20705 ENOG4108M3P Membrane HVX74_20710 ENOG4108MJ3 acetyltransferase HVX74_20715 ENOG4105KQT Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome (By similarity) HVX74_20730 ENOG4105XEP YhcH YjgK YiaL family protein HVX74_20735 ENOG4108XFH Transcriptional regulator HVX74_20740 ENOG4105F6U Short-chain dehydrogenase reductase Sdr HVX74_20745 ENOG4108UQ8 endoribonuclease L-psp HVX74_20750 ENOG4107C93 pyrBI operon leader peptide HVX74_20765 ENOG4105KME endoribonuclease L-psp HVX74_20775 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic HVX74_20785 ENOG4105D4X repressor HVX74_20790 ENOG4105C5Y PTS System HVX74_20795 ENOG4105CG3 alpha amylase, catalytic region HVX74_20800 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase HVX74_20805 ENOG4108RDD Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine (By similarity) HVX74_20815 ENOG4108XVM Cytochrome b(562) HVX74_20820 ENOG4105CMS peptidase U62, modulator of DNA gyrase HVX74_20830 ENOG4105DFU Cell wall formation (By similarity) HVX74_20840 ENOG41062B0 ABC transporter, permease HVX74_20845 ENOG4107R9N ABC transporter HVX74_20850 ENOG4105C2J ABC transporter HVX74_20855 ENOG4107R5U Periplasmic binding protein LacI transcriptional regulator HVX74_20860 ENOG4105F0N pyrophosphate phospho-hydrolase HVX74_20865 ENOG4105MZG transcriptional modulator of maze toxin, mazf HVX74_20870 ENOG41087RY SpoVT_AbrB HVX74_20875 ENOG4108ZHD aig2 family HVX74_20880 ENOG4105MA0 exported protein HVX74_20885 ENOG4105CFU surface antigen HVX74_20895 ENOG4105C37 (CBS) domain HVX74_20900 ENOG41061GZ Protein of unknown function (DUF1107) HVX74_20905 ENOG4108UUE Transcriptional regulator HVX74_20910 ENOG4108RNI 3'(2')5'-bisphosphate nucleotidase HVX74_20915 ENOG4107RNS bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase 3'-nucleotidase periplasmic HVX74_20920 ENOG4105KVH Transcriptional regulator HVX74_20925 ENOG4105ECR NmrA family HVX74_20930 ENOG4105DXC membrane HVX74_20950 ENOG4105C85 amino acid HVX74_20955 ENOG4108V1T peptidylprolyl cis-trans isomerase HVX74_20960 ENOG4105FHY Opacity-associated protein A HVX74_20970 ENOG4105CHR reductase HVX74_20980 ENOG4105E39 Enoyl-CoA hydratase HVX74_20985 ENOG4107R0K CoA transferase having broad substrate specificity for short-chain acyl-CoA thioesters with the activity decreasing when the length of the carboxylic acid chain exceeds four carbons (By similarity) HVX74_20990 ENOG4107S3R L-aspartate oxidase HVX74_20995 ENOG41069H7 transport system small permease component HVX74_21000 ENOG4105CG6 trap dicarboxylate transporter dctm subunit HVX74_21005 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit HVX74_21015 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) HVX74_21030 ENOG4105KIT UPF0379 protein yjfY HVX74_21035 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase HVX74_21045 ENOG4105H6Q decarboxylase HVX74_21055 ENOG410907W The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in ascorbate transport HVX74_21060 ENOG4105CZC PTS system ascorbate-specific transporter subunit IIC HVX74_21075 ENOG4108MXZ Esterase HVX74_21080 ENOG4105WSB biofilm stress and motility protein A HVX74_21085 ENOG4105S17 UPF0379 protein yjfN HVX74_21090 ENOG4105CSU acyl-Coa dehydrogenase HVX74_21095 ENOG4106032 Glutathionylspermidine synthase HVX74_21100 ENOG4108KXT Conserved Protein HVX74_21105 ENOG4105Z6B inner membrane protein yjfl HVX74_21110 ENOG4107VNS Protein of unknown function (DUF2491) HVX74_21115 ENOG4108P9J Phage shock protein A HVX74_21120 ENOG4105FUX Conserved Protein HVX74_21125 ENOG4105C2N RNA methyltransferase TrmH family group 3 HVX74_21130 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) HVX74_21150 ENOG4105EPW hflc protein HVX74_21155 ENOG4107QJR hflk protein HVX74_21160 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) HVX74_21180 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase HVX74_21185 ENOG4105K8N protein family UPF0079, ATPase HVX74_21190 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) HVX74_21195 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) HVX74_21235 ENOG4105EGS Mechanosensitive ion channel HVX74_21240 ENOG4106CG8 Inner membrane protein YjeO HVX74_21245 ENOG4106V5W HVX74_21250 ENOG4107SC7 Inner membrane transporter yjeM HVX74_21260 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) HVX74_21265 ENOG4105E33 succinate dehydrogenase HVX74_21280 ENOG41066YJ Beta-lactamase HVX74_21285 ENOG4105QNF Outer membrane lipoprotein HVX74_21290 ENOG4105KPY Small multidrug resistance protein HVX74_21295 ENOG4106BSU Entericidin B HVX74_21300 ENOG4107PEH Entericidin EcnA/B family HVX74_21310 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein HVX74_21315 ENOG4105MTB Uncharacterized protein YjeJ HVX74_21320 ENOG4108ZVF (LipO)protein HVX74_21335 ENOG4105DVH amino acid HVX74_21340 ENOG4108YH1 overproduction of this protein in Escherichia coli inhibits the F plasmid-mediated exclusion of bacteriophage T7 HVX74_21345 ENOG4108IJ0 Aspartate ammonia-lyase HVX74_21350 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter HVX74_21360 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) HVX74_21365 ENOG4108SIC Transcriptional regulator HVX74_21375 ENOG4108M3R transcriptional activator CadC HVX74_21380 ENOG4105D5Q Arginine ornithine antiporter HVX74_21385 ENOG4105CXN decarboxylase HVX74_21390 ENOG4105DUX Transporter HVX74_21395 ENOG4105CRK lysyL-tRNA synthetase HVX74_21410 ENOG410830R acetyltransferase HVX74_21415 ENOG4105VR1 Pfam:DUF1271 HVX74_21420 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism HVX74_21425 ENOG4108MRH transcriptional regulatory protein HVX74_21430 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter HVX74_21435 ENOG4107GFK fumarate HVX74_21440 ENOG4108R5S membrane HVX74_21445 ENOG4105CT4 transporter HVX74_21450 ENOG4105F8D glycoside hydrolase family 4 HVX74_21455 ENOG4108K2B transcriptional regulator HVX74_21460 ENOG4105CXN decarboxylase HVX74_21465 ENOG4106ZGR Transcriptional regulator HVX74_21470 ENOG4105D5Q Arginine ornithine antiporter HVX74_21475 ENOG4105DIJ Phosphoethanolamine transferase HVX74_21480 ENOG4105XJC Two component transcriptional regulator (Winged helix family HVX74_21485 ENOG4105ECM Sensor protein basS pmrB HVX74_21495 ENOG4105CSH Transporter HVX74_21500 ENOG4108YIV HVX74_21505 ENOG4108F5E vimentin HVX74_21510 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA HVX74_21515 ENOG4108SQ4 Glyoxalase Bleomycin resistance protein (Dioxygenase HVX74_21525 ENOG4105EHI Phosphonate ABC transporter, periplasmic HVX74_21535 ENOG4107RJJ Transcriptional regulator HVX74_21540 ENOG4105KQZ Phosphonate C-P lyase system protein PhnG HVX74_21545 ENOG4105KZ6 phosphonate C-P lyase system protein PhnH HVX74_21550 ENOG4105EKV Phosphonate metabolism protein HVX74_21555 ENOG4105FT8 Phosphonate metabolism HVX74_21560 ENOG4105ENV phosphonate C-P lyase system protein PhnK HVX74_21565 ENOG4105HRV phosphonate c-p lyase system protein phnl HVX74_21570 ENOG4105FD8 phosphonate metabolism protein PhnM HVX74_21580 ENOG410849A acetyltransferase, (GNAT) family HVX74_21585 ENOG4107SA6 carbon-phosphorus lyase complex accessory protein HVX74_21595 ENOG4105EUZ Beta-lactamase domain protein HVX74_21605 ENOG4105J12 Multidrug resistance protein mdtN HVX74_21610 ENOG4108MI0 Resistance protein HVX74_21615 ENOG4105ETP RND efflux system, outer membrane lipoprotein HVX74_21625 ENOG41082ND Uncharacterized protein yjcO HVX74_21630 ENOG4105CK2 sodium dicarboxylate symporter HVX74_21635 ENOG4108W0S formate-dependent nitrite reductase complex HVX74_21645 ENOG4108QKW cytochrome c-type biogenesis protein HVX74_21650 ENOG4105DVI reductase, NrfD HVX74_21655 ENOG4105D3S 4Fe-4S Ferredoxin, iron-sulfur binding domain protein HVX74_21660 ENOG4105JJ8 Cytochrome c nitrite reductase, pentaheme subunit HVX74_21670 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) HVX74_21675 ENOG41062QD Membrane HVX74_21685 ENOG4105EEQ Na H antiporter HVX74_21690 ENOG4105C7N Xanthine uracil vitamin C permease HVX74_21695 ENOG4108Z4X TRANSCRIPTIONal HVX74_21700 ENOG4108W3Q Transcriptional regulator HVX74_21705 ENOG4108M8H domain protein HVX74_21710 ENOG4105PMV Membrane HVX74_21715 ENOG4108UUM single-stranded DNA-binding protein HVX74_21720 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) HVX74_21725 ENOG4105MSB protein, conserved in bacteria HVX74_21730 ENOG4108YXI Secondary thiamine-phosphate synthase enzyme HVX74_21735 ENOG4105F0S class B acid phosphatase HVX74_21740 ENOG4105CQZ Histidine kinase HVX74_21745 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family HVX74_21750 ENOG4105DG4 malate L-lactate dehydrogenase HVX74_21755 ENOG4107QPK )-transporter HVX74_21760 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha HVX74_21765 ENOG4105CMV Succinyl-CoA synthetase subunit beta HVX74_21770 ENOG4107QN2 dihydrolipoyl dehydrogenase HVX74_21775 ENOG4105C7S Dehydrogenase HVX74_21780 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 HVX74_21785 ENOG4105CGF Aromatic amino acid aminotransferase HVX74_21790 ENOG4107VZS Nicotinamide-nucleotide adenylyltransferase HVX74_21795 ENOG4106Z1T Nicotinamide Mononucleotide Transporter HVX74_21800 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) HVX74_21805 ENOG4105CDU Replicative dna helicase HVX74_21810 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein HVX74_21815 ENOG4105P4Z Phage shock protein G HVX74_21820 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) HVX74_21830 ENOG4106FE3 DNA repair HVX74_21835 ENOG4105DFP Integrase HVX74_21850 ENOG4105Y9F tail fiber protein HVX74_21855 ENOG4105Y0G tail protein HVX74_21860 ENOG4108T86 baseplate J family protein HVX74_21880 ENOG4108NKR DNA circulation protein HVX74_21900 ENOG4105TKZ Tail Sheath HVX74_21945 ENOG4105EFC phage portal protein HK97 family HVX74_21955 ENOG4105CAR Terminase, large subunit HVX74_21990 ENOG4105HGD Antitermination protein HVX74_21995 ENOG4108MXB Protein of unknown function (DUF968) HVX74_22005 ENOG4106CZA Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC (By similarity) HVX74_22030 ENOG4108S1U HVX74_22045 ENOG4105H40 HVX74_22050 ENOG4108HJ1 Uncharacterized conserved protein (DUF2303) HVX74_22055 ENOG4108R7K Metal Dependent Phosphohydrolase HVX74_22100 ENOG4105MYN Zinc uptake regulation protein HVX74_22105 ENOG4105VDW Csbd family HVX74_22110 ENOG4107R73 Mate efflux family protein HVX74_22120 ENOG41080IJ Diacylglycerol kinase HVX74_22140 ENOG4107W52 maltose operon periplasmic protein HVX74_22150 ENOG4108IJ9 (ABC) transporter HVX74_22155 ENOG4107FKK extracellular solute-binding protein family 1 HVX74_22160 ENOG4105D56 permease protein HVX74_22165 ENOG4105EG2 ABC transporter, permease HVX74_22170 ENOG4107QNK )-transporter HVX74_22185 ENOG4105E3R (LipO)protein HVX74_22190 ENOG4108Q9C Periplasmic Protein HVX74_22195 ENOG4108MDC (LipO)protein HVX74_22210 ENOG4105CFH Aspartokinase HVX74_22215 ENOG4108ZR5 Conserved Protein HVX74_22220 ENOG4105FE9 pseudouridine synthase HVX74_22225 ENOG4105DKT Transcriptional regulator HVX74_22230 ENOG4105CHR reductase HVX74_22235 ENOG4108XCU pts system HVX74_22240 ENOG4105KPI PTS system sorbose subfamily IIB component HVX74_22245 ENOG4105ETZ PTS System HVX74_22250 ENOG4105F3R pts system mannose fructose sorbose family iid HVX74_22255 ENOG4105DXH Alcohol dehydrogenase zinc-binding domain protein HVX74_22265 ENOG4105EAM Na Pi-cotransporter HVX74_22270 ENOG4105C3R Methionine synthase HVX74_22275 ENOG41069M3 Transcriptional regulator HVX74_22280 ENOG4105VS7 Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation (By similarity) HVX74_22285 ENOG4108I9X Isocitrate lyase HVX74_22290 ENOG4107QP3 malate synthase g HVX74_22295 ENOG4105CVG Homoserine O-transsuccinylase HVX74_22300 ENOG4105K5X acetyltransferase HVX74_22305 ENOG41062WK cellular response to acidity HVX74_22335 ENOG4105C12 Phosphoribosylglycinamide synthetase HVX74_22340 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family HVX74_22345 ENOG4105BZU Histidine kinase HVX74_22350 ENOG4105JBU Binds zinc. Could be an important component of the zinc- balancing mechanism HVX74_22355 ENOG4108T8B Protein of unknown function (DUF1481) HVX74_22365 ENOG4105R2J Conserved Protein HVX74_22385 ENOG4107MNS Has binding activity to the major sigma subunit of RNA polymerase. May be involved in replacement of the RNA polymerase sigma subunit from sigma-70 to sigma-S during the transition from exponential growth to the stationary phase (By similarity) HVX74_22400 ENOG4105D06 uba thif-type nad fad binding protein HVX74_22405 ENOG4105WHD thiamine biosynthesis protein ThiS HVX74_22415 ENOG4105D41 biosynthesis protein thiH HVX74_22450 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) HVX74_22455 ENOG4105PM1 preprotein translocase subunit SecE HVX74_22490 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase HVX74_22525 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) HVX74_22535 ENOG4108Y73 Membrane HVX74_22540 ENOG4105EJ2 Transcriptional regulator HVX74_22550 ENOG4105CH2 amidohydrolase HVX74_22560 ENOG4105C5Q Transcriptional regulator HVX74_22575 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase HVX74_22590 ENOG4105DIJ Phosphoethanolamine transferase HVX74_22595 ENOG4106R3P AraC family transcriptional regulator HVX74_22600 ENOG4108XCZ PTS System HVX74_22605 ENOG4108AHH pyruvate formate lyase II activase HVX74_22615 ENOG4108YRF PTS System HVX74_22620 ENOG4105DM4 PTS System HVX74_22625 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) HVX74_22630 ENOG4107T9Z Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) HVX74_22635 ENOG4105DCT glycerol dehydrogenase HVX74_22640 ENOG4108XC3 NADH ubiquinone oxidoreductase HVX74_22645 ENOG4108Q5Y Membrane HVX74_22655 ENOG4105SYT Methylenetetrahydrofolate reductase HVX74_22660 ENOG4105CGH 5'-nucleotidase HVX74_22670 ENOG4105CFH Aspartokinase HVX74_22675 ENOG4105C28 cystathionine HVX74_22685 ENOG4107S01 Repressor protein MetJ HVX74_22695 ENOG4105C25 Primosomal protein n' HVX74_22700 ENOG4105ETE Transcriptional regulator (LacI family HVX74_22705 ENOG41063M6 Cell Division Protein HVX74_22720 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase HVX74_22735 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) HVX74_22745 ENOG4105CBT Fructose-1,6-bisphosphatase HVX74_22750 ENOG4105DP0 ferredoxin-NADP reductase HVX74_22760 ENOG41065TG regulatoR HVX74_22765 ENOG4108VTS Membrane HVX74_22770 ENOG4105EBK exported protein HVX74_22780 ENOG4105C54 Major Facilitator superfamily HVX74_22785 ENOG4108JUB Transcriptional regulator HVX74_22790 ENOG4105CXK mandelate racemase muconate lactonizing HVX74_22795 ENOG4108ITV Inner membrane protein yqcE HVX74_22805 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein HVX74_22820 ENOG4105FMW periplasmic HVX74_22825 ENOG4105E3W Two component transcriptional regulator (Winged helix family HVX74_22830 ENOG4105E0F Histidine kinase HVX74_22835 ENOG4108RPX mosc domain containing protein HVX74_22845 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) HVX74_22890 ENOG41064BA PTS system, fructose-specific, IIA component HVX74_22900 ENOG4105CN9 Peptidase m42 family protein HVX74_22905 ENOG4106C3V frv operon regulatory protein HVX74_22910 ENOG4108V87 frv operon regulatory protein HVX74_22920 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) HVX74_22935 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein HVX74_22940 ENOG4108MG3 formate dehydrogenase HVX74_22950 ENOG41068KX affects formate dehydrogenase-N HVX74_22960 ENOG4105SUU thioesterase domain HVX74_22975 ENOG4105EJU HAD-superfamily hydrolase subfamily IA variant 3 HVX74_22985 ENOG4105CSH Transporter HVX74_22995 ENOG4105CPQ Dehydrogenase HVX74_23000 ENOG4105D2M Aldolase HVX74_23005 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase HVX74_23010 ENOG4108MGF sugar kinase HVX74_23015 ENOG4105E98 transcriptional regulator DeoR family HVX74_23020 ENOG4105CI3 gtp-binding protein typa HVX74_23025 ENOG4105C5F glutamine synthetase HVX74_23030 ENOG4105CUX Signal transduction histidine kinase HVX74_23035 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family HVX74_23040 ENOG4106FIY HVX74_23045 ENOG4105D4P Coproporphyrinogen iii oxidase HVX74_23050 ENOG4105ZR3 A GTPase-activating protein (GAP) that modifies Der EngA GTPase function. May play a role in ribosome biogenesis (By similarity) HVX74_23060 ENOG4105C2M dna polymerase I HVX74_23065 ENOG4106HNH Acyl-transferase HVX74_23075 ENOG4108Z33 Thiol disulfide Interchange Protein HVX74_23080 ENOG4105E27 serine threonine protein kinase HVX74_23085 ENOG4105PC1 Conserved Protein HVX74_23090 ENOG4105C6R Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) HVX74_23095 ENOG4105FNP Molybdopterin-guanine dinucleotide biosynthesis protein b HVX74_23125 ENOG4108RR8 protoporphyrinogen oxidase HVX74_23130 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) HVX74_23135 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein HVX74_23155 ENOG4108EX3 reductase HVX74_23160 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) HVX74_23165 ENOG4105MDZ Transcriptional activator rfaH HVX74_23175 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) HVX74_23180 ENOG4105X8U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity) HVX74_23185 ENOG4105WKS Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) HVX74_23195 ENOG4105JC1 sterol-binding domain protein HVX74_23205 ENOG4105CGY Dna recombination protein HVX74_23210 ENOG4107HP6 Transcriptional regulator HVX74_23215 ENOG4105EI3 2-dehydro-3-deoxygalactonokinase EC 2.7.1.58 HVX74_23220 ENOG4108RTU Aldolase HVX74_23225 ENOG4105JN3 extra-cytoplasmic solute receptor family protein HVX74_23240 ENOG4108I5U Uridine phosphorylase HVX74_23245 ENOG4105CDZ Carboxymethylenebutenolidase (EC 3.1.1.45) HVX74_23250 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) HVX74_23255 ENOG4105DZ2 Transcriptional regulator HVX74_23260 ENOG4105EMK carboxylate amino acid amine transporter HVX74_23265 ENOG4105DQF Hydrolase HVX74_23270 ENOG4108EUD Lysophospholipase HVX74_23275 ENOG410829K Lysine exporter protein (Lyse ygga) HVX74_23280 ENOG4105CCF Lysine exporter protein (Lyse ygga) HVX74_23285 ENOG4105C9U ATP-dependent DNA helicase RecQ HVX74_23290 ENOG4105HDD phospholipase HVX74_23295 ENOG4108VUY thioesterase Superfamily protein HVX74_23300 ENOG4105FR1 rard protein HVX74_23305 ENOG4107QUT magnesium and cobalt transport protein CorA HVX74_23310 ENOG4108T58 Mg2 transport protein CorA HVX74_23315 ENOG4107V4F S-adenosyl-l-methionine hydroxide adenosyltransferase HVX74_23320 ENOG4105C4R Atp-dependent dna helicase HVX74_23325 ENOG4105DFC had-superfamily hydrolase, subfamily ia, variant HVX74_23335 ENOG4105CT0 Protein of unknown function, DUF484 HVX74_23345 ENOG4105S7Z (LipO)protein HVX74_23365 ENOG4107T0K Adenylate cyclase HVX74_23375 ENOG41076E6 Uroporphyrinogen-III Synthase HVX74_23380 ENOG4105ECF c-methyltransferase HVX74_23385 ENOG410601J HemY protein HVX74_23395 ENOG4105ENH Sulfatase HVX74_23400 ENOG4105C4X radical SAM domain protein HVX74_23425 ENOG4105C85 amino acid HVX74_23445 ENOG4105EGZ biosynthesis protein HVX74_23450 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase HVX74_23455 ENOG4108WJ1 acetyltransferase HVX74_23460 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) HVX74_23465 ENOG4105C1B dTDP-glucose 4-6-dehydratase HVX74_23470 ENOG4107QQG Dehydrogenase HVX74_23475 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase HVX74_23480 ENOG4105SFE lipopolysaccharide biosynthesis protein HVX74_23485 ENOG4105ESV Glycosyl transferase, family 4 HVX74_23490 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) HVX74_23515 ENOG4105C4R Atp-dependent dna helicase HVX74_23525 ENOG4105KQ5 peptidylprolyl cis-trans isomerase HVX74_23535 ENOG4105EMY transcriptional regulator HVX74_23540 ENOG4105C7B Threonine dehydratase HVX74_23550 ENOG4105CM2 brancheD-chain amino acid aminotransferase HVX74_23555 ENOG4105P3Y Acetolactate synthase 2 regulatory subunit HVX74_23575 ENOG4105C0P Mg chelatase subunit ChlI HVX74_23580 ENOG4108WFC UPF0438 protein yifE HVX74_23620 ENOG4107EJG GntR family transcriptional regulator HVX74_23625 ENOG4105C0R drug resistance transporter emrb qaca subfamily HVX74_23630 ENOG4105ETE Transcriptional regulator (LacI family HVX74_23635 ENOG4108RVA ribokinase HVX74_23640 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator HVX74_23645 ENOG4105CNN ABC, transporter HVX74_23650 ENOG4105C2J ABC transporter HVX74_23670 ENOG4105EV2 VWA domain protein interacting with AAA ATPase HVX74_23680 ENOG4108VVK transcriptional Regulator, AsnC HVX74_23685 ENOG4105QTB Flavodoxin HVX74_23700 ENOG4105GXX Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit I associates with the membrane and may be involved with cation translocation HVX74_23750 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) HVX74_23755 ENOG4107QMV Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity) HVX74_23760 ENOG4105C8U phosphate abc transporter HVX74_23765 ENOG4105E2Z phosphate ABC transporter (Permease HVX74_23770 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) HVX74_23775 ENOG4108UTW Plays a role in the regulation of phosphate uptake HVX74_23780 ENOG4106611 bacteriocin immunity HVX74_23785 ENOG4107UB3 HAD-superfamily hydrolase subfamily IA variant 3 HVX74_23790 ENOG4105C7N Xanthine uracil vitamin C permease HVX74_23795 ENOG4108YYH Nadph-dependent fmn reductase HVX74_23800 ENOG4105E8Q phosphopantetheinyl transferase HVX74_23810 ENOG4105CNH Multidrug resistance protein MdtL HVX74_23815 ENOG4108P6C Tryptophan transporter of low affinity HVX74_23850 ENOG4105VG0 50S ribosomal protein l34 HVX74_23895 ENOG4106PHM regulatory protein HVX74_23915 ENOG4105DWP Membrane HVX74_23930 ENOG4106CQM replication HVX74_23940 ENOG4107AVE This protein is involved in the determination of copy number in gene replication. It binds to the repA promoter thus inhibiting the synthesis of the mRNA for the initiator protein repA (By similarity) HVX74_23950 ENOG4105KK6 nuclease HVX74_23955 ENOG4105E5H Transposase HVX74_23960 ENOG4108YXQ IS66 Orf2 family protein HVX74_23975 ENOG4107CBI conjugal transfer fertility inhibition protein HVX74_23980 ENOG4107U2T alpha beta HVX74_23995 ENOG4105VGJ Virulence-associated protein HVX74_24000 ENOG4105M0J Toxic component of a toxin-antitoxin (TA) module. A HVX74_24195 ENOG4105FEQ ParB domain protein nuclease HVX74_24225 ENOG4106JQ7 HVX74_24230 ENOG41073YN Protein of unknown function (DUF1380)