locus-tag	class	description
HVX74_00010	COG0592	DNA-directed DNA polymerase activity
HVX74_00020	COG0187	DNA topoisomerase II activity
HVX74_00025	COG3753	Protein conserved in bacteria
HVX74_00030	COG0561	phosphatase activity
HVX74_00040	COG2186	Transcriptional regulator
HVX74_00045	COG3734	2-keto-3-deoxy-galactonokinase
HVX74_00050	COG0800	Aldolase
HVX74_00060	COG2271	Major facilitator Superfamily
HVX74_00070	COG0823	Involved in the tonB-independent uptake of proteins
HVX74_00075	COG5645	(Lipo)protein
HVX74_00095	COG2188	Transcriptional regulator
HVX74_00105	COG2207	Transcriptional regulator
HVX74_00110	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HVX74_00115	COG3119	arylsulfatase activity
HVX74_00125	COG2149	membrane
HVX74_00135	COG0641	radical SAM
HVX74_00140	COG2814	Major facilitator Superfamily
HVX74_00155	COG0028	Belongs to the TPP enzyme family
HVX74_00160	COG0440	acetolactate synthase activity
HVX74_00180	COG2197	response regulator
HVX74_00185	COG3851	Histidine kinase
HVX74_00190	COG2271	Major facilitator Superfamily
HVX74_00195	COG2271	Major facilitator Superfamily
HVX74_00210	COG1447	Phosphotransferase system cellobiose-specific component IIA
HVX74_00215	COG2723	6-phospho-beta-galactosidase activity
HVX74_00220	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HVX74_00230	COG1609	Transcriptional regulator
HVX74_00245	COG2252	PERMEase
HVX74_00265	COG1464	Belongs to the NlpA lipoprotein family
HVX74_00270	COG0697	spore germination
HVX74_00275	COG2814	Major facilitator Superfamily
HVX74_00315	COG2003	Belongs to the UPF0758 family
HVX74_00340	COG2378	regulation of single-species biofilm formation
HVX74_00345	COG3596	GTP binding
HVX74_00450	COG0786	glutamate:sodium symporter activity
HVX74_00465	COG0640	Transcriptional regulator
HVX74_00520	COG2194	sulfuric ester hydrolase activity
HVX74_00530	COG0582	viral genome integration into host DNA
HVX74_00540	COG2211	Major facilitator Superfamily
HVX74_00545	COG1501	Belongs to the glycosyl hydrolase 31 family
HVX74_00550	COG2982	Protein involved in outer membrane biogenesis
HVX74_00555	COG2233	PERMEase
HVX74_00560	COG0786	glutamate:sodium symporter activity
HVX74_00570	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HVX74_00575	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HVX74_00580	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HVX74_00590	COG0194	GDP metabolic process
HVX74_00600	COG2860	membrane
HVX74_00625	COG1561	YicC-like family, N-terminal region
HVX74_00650	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HVX74_00680	COG1519	Transferase
HVX74_00685	COG0859	PFAM glycosyl transferase family 9
HVX74_00690	COG0438	transferase activity, transferring glycosyl groups
HVX74_00695	COG0515	serine threonine protein kinase
HVX74_00710	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HVX74_00715	COG1442	glycosyl transferase family 8
HVX74_00720	COG1216	Glycosyl transferase, family 2
HVX74_00725	COG3307	-O-antigen
HVX74_00730	COG0859	PFAM glycosyl transferase family 9
HVX74_00735	COG0859	PFAM glycosyl transferase family 9
HVX74_00745	COG0156	8-amino-7-oxononanoate synthase activity
HVX74_00755	COG1216	Glycosyl transferase, family 2
HVX74_00760	COG2861	carbohydrate metabolic process
HVX74_00765	COG4942	peptidase
HVX74_00775	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HVX74_00780	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HVX74_00795	COG1045	serine acetyltransferase
HVX74_00800	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HVX74_00810	COG2186	Transcriptional regulator
HVX74_00815	COG1620	l-lactate permease
HVX74_00820	COG5295	Hep Hag repeat protein
HVX74_00840	COG3722	fumarate hydratase activity
HVX74_00850	COG2213	PTS system mannitol-specific
HVX74_00850	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HVX74_00860	COG1566	PFAM secretion protein HlyD family protein
HVX74_00865	COG0625	glutathione transferase activity
HVX74_00875	COG3276	selenocysteine insertion sequence binding
HVX74_00880	COG1454	alcohol dehydrogenase
HVX74_00885	COG1012	belongs to the aldehyde dehydrogenase family
HVX74_00890	COG0235	Class ii aldolase
HVX74_00895	COG3623	hexulose-6-phosphate isomerase
HVX74_00900	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
HVX74_00905	COG1070	Carbohydrate kinase
HVX74_00910	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HVX74_00915	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HVX74_00920	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
HVX74_00925	COG2731	YhcH YjgK YiaL family protein
HVX74_00935	COG1414	Transcriptional regulator
HVX74_00940	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HVX74_00945	COG3977	Valine--pyruvate aminotransferase
HVX74_00950	COG0366	Alpha amylase catalytic
HVX74_00955	COG2992	FlgJ-related protein
HVX74_00960	COG1609	Transcriptional regulator
HVX74_00960	COG2207	Transcriptional regulator
HVX74_00965	COG4214	carbohydrate transport
HVX74_00975	COG4213	ABC transporter substrate-binding protein
HVX74_00985	COG1070	Carbohydrate kinase
HVX74_00990	COG4682	membrane
HVX74_00995	COG4682	membrane
HVX74_01000	COG3274	enterobacterial common antigen metabolic process
HVX74_01025	COG1278	Cold shock
HVX74_01030	COG2944	sequence-specific DNA binding
HVX74_01045	COG2885	chlorophyll binding
HVX74_01050	COG0243	molybdopterin cofactor binding
HVX74_01055	COG0456	acetyltransferase
HVX74_01060	COG2818	Glycosylase
HVX74_01065	COG5571	outer membrane autotransporter
HVX74_01070	COG2223	nitrite transmembrane transporter activity
HVX74_01075	COG2194	sulfuric ester hydrolase activity
HVX74_01090	COG0747	negative chemotaxis
HVX74_01095	COG0601	transmembrane transport
HVX74_01100	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HVX74_01105	COG0444	Belongs to the ABC transporter superfamily
HVX74_01110	COG4608	Belongs to the ABC transporter superfamily
HVX74_01115	COG0814	amino acid
HVX74_01135	COG2194	sulfuric ester hydrolase activity
HVX74_01160	COG1215	transferase activity, transferring glycosyl groups
HVX74_01165	COG1215	transferase activity, transferring glycosyl groups
HVX74_01170	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
HVX74_01175	COG3118	belongs to the thioredoxin family
HVX74_01175	COG0457	Tetratricopeptide repeat
HVX74_01180	COG2200	EAL domain
HVX74_01180	COG2199	diguanylate cyclase activity
HVX74_01190	COG0612	Peptidase, M16
HVX74_01195	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HVX74_01200	COG2200	EAL domain
HVX74_01205	COG2982	Protein involved in outer membrane biogenesis
HVX74_01210	COG0477	Major facilitator Superfamily
HVX74_01215	COG1295	ribonuclease BN
HVX74_01220	COG0583	DNA-binding transcription factor activity
HVX74_01225	COG2197	response regulator
HVX74_01235	COG1858	cytochrome C peroxidase
HVX74_01240	COG0076	glutamate decarboxylase activity
HVX74_01250	COG2207	Transcriptional regulator
HVX74_01255	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HVX74_01260	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HVX74_01270	COG2771	luxR family
HVX74_01275	COG3247	response to pH
HVX74_01290	COG1285	pathogenesis
HVX74_01300	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HVX74_01310	COG3721	Heme iron utilization protein
HVX74_01320	COG4558	Periplasmic binding protein
HVX74_01325	COG4771	TonB-dependent receptor
HVX74_01330	COG3720	iron ion transport
HVX74_01335	COG2197	response regulator
HVX74_01340	COG3065	identical protein binding
HVX74_01360	COG1393	Belongs to the ArsC family
HVX74_01365	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HVX74_01370	COG0640	Transcriptional regulator
HVX74_01385	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HVX74_01390	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
HVX74_01395	COG0339	signal peptide processing
HVX74_01405	COG3104	oligopeptide transport
HVX74_01410	COG0589	response to stress
HVX74_01420	COG0306	phosphate transporter
HVX74_01425	COG2081	HI0933 family
HVX74_01435	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HVX74_01440	COG0842	Transport permease protein
HVX74_01440	COG1129	ABC transporter
HVX74_01445	COG0842	Transport permease protein
HVX74_01450	COG0191	fructose-bisphosphate aldolase activity
HVX74_01465	COG3775	system Galactitol-specific IIC component
HVX74_01470	COG3414	Phosphotransferase system galactitol-specific IIB component
HVX74_01480	COG2188	Transcriptional regulator
HVX74_01500	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HVX74_01505	COG0601	transmembrane transport
HVX74_01510	COG0747	negative chemotaxis
HVX74_01515	COG2091	lysine biosynthetic process via aminoadipic acid
HVX74_01520	COG0628	permease
HVX74_01525	COG0477	Major facilitator Superfamily
HVX74_01535	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
HVX74_01550	COG3714	YhhN family
HVX74_01560	COG3776	membrane
HVX74_01565	COG0742	ribosomal rna small subunit methyltransferase
HVX74_01570	COG0552	protein localization to endoplasmic reticulum
HVX74_01575	COG2884	Cell division ATP-binding protein ftsE
HVX74_01580	COG2177	Part of the ABC transporter FtsEX involved in
HVX74_01585	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HVX74_01590	COG0683	leucine binding
HVX74_01595	COG0456	acetyltransferase
HVX74_01600	COG0683	leucine binding
HVX74_01605	COG0559	Belongs to the binding-protein-dependent transport system permease family
HVX74_01610	COG4177	L-phenylalanine transmembrane transporter activity
HVX74_01615	COG0411	ABC transporter
HVX74_01620	COG0410	ABC transporter
HVX74_01625	COG1653	transport
HVX74_01630	COG1175	transmembrane transport
HVX74_01645	COG0584	glycerophosphoryl diester phosphodiesterase
HVX74_01655	COG0405	Gamma-glutamyltransferase
HVX74_01665	COG1247	-acetyltransferase
HVX74_01670	COG0673	inositol 2-dehydrogenase activity
HVX74_01675	COG1741	Belongs to the pirin family
HVX74_01680	COG1609	Transcriptional regulator
HVX74_01685	COG3265	gluconokinase activity
HVX74_01690	COG2610	gluconate transmembrane transporter activity
HVX74_01695	COG2095	MarC family integral membrane protein
HVX74_01700	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HVX74_01705	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HVX74_01725	COG0058	SHG alpha-glucan phosphorylase activity
HVX74_01735	COG3121	Chaperone
HVX74_01740	COG3188	usher protein
HVX74_01745	COG3539	Fimbrial protein
HVX74_01755	COG3121	Chaperone
HVX74_01765	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HVX74_01780	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HVX74_01795	COG1349	DNA-binding transcription factor activity
HVX74_01800	COG4650	regulator
HVX74_01805	COG1690	Belongs to the RtcB family
HVX74_01820	COG0058	SHG alpha-glucan phosphorylase activity
HVX74_01825	COG1640	4-alpha-glucanotransferase
HVX74_01830	COG2610	gluconate transmembrane transporter activity
HVX74_01860	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
HVX74_01865	COG1918	ferrous iron import across plasma membrane
HVX74_01870	COG2183	response to ionizing radiation
HVX74_01875	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HVX74_01880	COG0745	RESPONSE REGULATOR receiver
HVX74_01885	COG2205	protein histidine kinase activity
HVX74_01895	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
HVX74_01905	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HVX74_01910	COG1011	Hydrolase
HVX74_01920	COG0494	nUDIX hydrolase
HVX74_01925	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
HVX74_01930	COG4972	Pilus assembly protein
HVX74_01935	COG3166	PFAM Fimbrial assembly family protein
HVX74_01950	COG4796	Type ii and iii secretion system protein
HVX74_01965	COG3266	domain, Protein
HVX74_01970	COG0338	D12 class N6 adenine-specific DNA methyltransferase
HVX74_01975	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HVX74_01985	COG0180	Tryptophanyl-tRNA synthetase
HVX74_01990	COG2188	Transcriptional regulator
HVX74_02000	COG3457	Alanine racemase
HVX74_02005	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
HVX74_02010	COG1735	metal-dependent hydrolase with the TIM-barrel fold
HVX74_02025	COG0626	cystathionine gamma-synthase activity
HVX74_02030	COG2188	Transcriptional regulator
HVX74_02040	COG1082	Xylose isomerase domain protein TIM barrel
HVX74_02045	COG2222	sugar isomerase
HVX74_02050	COG0531	amino acid
HVX74_02065	COG2116	formate transmembrane transporter activity
HVX74_02070	COG2146	nitrite reductase [NAD(P)H] activity
HVX74_02075	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HVX74_02085	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HVX74_02095	COG2184	nucleotidyltransferase activity
HVX74_02100	COG0512	Glutamine amidotransferase of anthranilate synthase
HVX74_02105	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HVX74_02110	COG1289	transmembrane transporter activity
HVX74_02115	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HVX74_02120	COG1765	OsmC-like protein
HVX74_02125	COG3954	Phosphoribulokinase
HVX74_02135	COG0429	hydrolase of the alpha beta-hydrolase fold
HVX74_02140	COG0488	(ABC) transporter
HVX74_02155	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
HVX74_02160	COG1047	Peptidyl-prolyl cis-trans
HVX74_02170	COG0545	Peptidyl-prolyl cis-trans isomerase
HVX74_02175	COG2964	Protein conserved in bacteria
HVX74_02245	COG0089	rRNA binding
HVX74_02335	COG0201	protein transport
HVX74_02375	COG0789	Transcriptional regulator
HVX74_02380	COG3036	rescue of stalled ribosome
HVX74_02390	COG0569	domain protein
HVX74_02410	COG0758	DNA mediated transformation
HVX74_02420	COG0551	DNA topoisomerase type I activity
HVX74_02440	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HVX74_02480	COG1126	abc transporter atp-binding protein
HVX74_02485	COG0765	amino acid transport
HVX74_02490	COG4597	amino acid ABC transporter
HVX74_02495	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HVX74_02505	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HVX74_02510	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HVX74_02525	COG2189	Belongs to the N(4) N(6)-methyltransferase family
HVX74_02535	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HVX74_02545	COG4145	pantothenate transmembrane transporter activity
HVX74_02550	COG3924	membrane
HVX74_02555	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HVX74_02560	COG1349	DNA-binding transcription factor activity
HVX74_02570	COG1879	ABC-type sugar transport system periplasmic component
HVX74_02575	COG1129	ABC transporter
HVX74_02580	COG1172	Belongs to the binding-protein-dependent transport system permease family
HVX74_02585	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HVX74_02595	COG0439	Biotin carboxylase
HVX74_02600	COG0511	ligase activity, forming carbon-carbon bonds
HVX74_02610	COG0604	alcohol dehydrogenase
HVX74_02615	COG2199	diguanylate cyclase activity
HVX74_02615	COG2200	EAL domain
HVX74_02620	COG1077	Cell shape determining protein MreB Mrl
HVX74_02625	COG1792	Involved in formation and maintenance of cell shape
HVX74_02630	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
HVX74_02640	COG1530	ribonuclease E activity
HVX74_02645	COG3164	Protein of unknown function
HVX74_02650	COG0312	modulator of DNA gyrase
HVX74_02655	COG0583	DNA-binding transcription factor activity
HVX74_02675	COG2732	(Barnase) inhibitor
HVX74_02695	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HVX74_02700	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HVX74_02705	COG3105	Protein conserved in bacteria
HVX74_02710	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
HVX74_02725	COG0625	glutathione transferase activity
HVX74_02730	COG2969	positive regulation of protein catabolic process
HVX74_02735	COG3069	C4-dicarboxylate transmembrane transporter activity
HVX74_02765	COG2731	YhcH YjgK YiaL family protein
HVX74_02770	COG0493	'glutamate synthase
HVX74_02775	COG0070	glutamate synthase
HVX74_02775	COG0067	glutamate synthase
HVX74_02775	COG0069	glutamate synthase activity
HVX74_02780	COG1242	4 iron, 4 sulfur cluster binding
HVX74_02785	COG0784	Response regulator, receiver
HVX74_02785	COG2198	Histidine kinase
HVX74_02785	COG5002	protein histidine kinase activity
HVX74_02790	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
HVX74_02800	COG0515	serine threonine protein kinase
HVX74_02805	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HVX74_02820	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HVX74_02825	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
HVX74_02830	COG1137	ATPase activity
HVX74_02835	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
HVX74_02840	COG3117	lipopolysaccharide transmembrane transporter activity
HVX74_02845	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
HVX74_02850	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HVX74_02850	COG0517	IMP dehydrogenase activity
HVX74_02855	COG0530	calcium, potassium:sodium antiporter activity
HVX74_02860	COG1127	ABC transporter
HVX74_02865	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HVX74_02870	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HVX74_02875	COG2854	intermembrane phospholipid transfer
HVX74_02880	COG3113	response to antibiotic
HVX74_02885	COG5007	Belongs to the BolA IbaG family
HVX74_02895	COG3423	Transcriptional regulator
HVX74_02900	COG0142	geranyltranstransferase activity
HVX74_02915	COG0697	spore germination
HVX74_02925	COG2027	D-alanyl-D-alanine carboxypeptidase
HVX74_02930	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HVX74_02935	COG1534	Rna-binding protein
HVX74_02945	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HVX74_02950	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HVX74_02960	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HVX74_02990	COG0195	Participates in both transcription termination and antitermination
HVX74_03030	COG0513	Belongs to the DEAD box helicase family
HVX74_03035	COG0814	amino acid
HVX74_03040	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HVX74_03045	COG0826	peptidase U32
HVX74_03050	COG0826	peptidase U32
HVX74_03055	COG3154	lipid carrier protein
HVX74_03060	COG3153	acetyltransferase
HVX74_03075	COG0693	protein deglycase activity
HVX74_03080	COG0702	epimerase
HVX74_03085	COG0701	Predicted permease
HVX74_03090	COG2823	Periplasmic or secreted lipoprotein
HVX74_03110	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HVX74_03115	COG3539	Fimbrial protein
HVX74_03120	COG3188	usher protein
HVX74_03125	COG3121	Chaperone
HVX74_03130	COG3539	Fimbrial protein
HVX74_03135	COG0363	glucosamine-6-phosphate deaminase activity
HVX74_03140	COG3716	PTS system mannose fructose sorbose family IID component
HVX74_03145	COG3715	PTS system
HVX74_03150	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HVX74_03160	COG2222	sugar isomerase
HVX74_03165	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HVX74_03170	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HVX74_03175	COG3716	PTS system mannose fructose sorbose family IID component
HVX74_03185	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HVX74_03195	COG1349	DNA-binding transcription factor activity
HVX74_03205	COG2002	toxin-antitoxin pair type II binding
HVX74_03210	COG2721	sulfolactate sulfo-lyase activity
HVX74_03215	COG2271	Major facilitator Superfamily
HVX74_03225	COG2084	Dehydrogenase
HVX74_03230	COG1929	Belongs to the glycerate kinase type-1 family
HVX74_03245	COG0583	DNA-binding transcription factor activity
HVX74_03250	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HVX74_03260	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HVX74_03265	COG1882	Formate acetyltransferase
HVX74_03270	COG0251	oxidation-reduction process
HVX74_03275	COG1760	l-serine dehydratase
HVX74_03280	COG0814	amino acid
HVX74_03295	COG1741	Belongs to the pirin family
HVX74_03300	COG0583	DNA-binding transcription factor activity
HVX74_03310	COG3152	Membrane
HVX74_03315	COG0435	Glutathione S-transferase
HVX74_03320	COG2259	Doxx family
HVX74_03330	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
HVX74_03335	COG4575	ribosome binding
HVX74_03340	COG1422	Protein of unknown function (DUF1090)
HVX74_03350	COG0586	Pfam SNARE associated Golgi protein
HVX74_03355	COG2186	Transcriptional regulator
HVX74_03360	COG2271	Major facilitator Superfamily
HVX74_03370	COG2721	sulfolactate sulfo-lyase activity
HVX74_03380	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
HVX74_03385	COG0861	Integral membrane protein TerC family
HVX74_03390	COG0673	inositol 2-dehydrogenase activity
HVX74_03395	COG2949	membrane
HVX74_03400	COG1451	nucleotide metabolic process
HVX74_03415	COG5499	transcription regulator containing HTH domain
HVX74_03420	COG0446	pyridine nucleotide-disulphide oxidoreductase
HVX74_03420	COG1902	pentaerythritol trinitrate reductase activity
HVX74_03425	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
HVX74_03425	COG3408	Glycogen debranching enzyme
HVX74_03435	COG0531	amino acid
HVX74_03440	COG2731	YhcH YjgK YiaL family protein
HVX74_03445	COG3250	beta-galactosidase activity
HVX74_03450	COG1609	Transcriptional regulator
HVX74_03455	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HVX74_03465	COG0840	transmembrane signaling receptor activity
HVX74_03470	COG1695	Transcriptional regulator
HVX74_03475	COG2375	cellular response to nickel ion
HVX74_03490	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HVX74_03495	COG0358	DNA primase activity
HVX74_03500	COG0828	Belongs to the bacterial ribosomal protein bS21 family
HVX74_03515	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HVX74_03520	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
HVX74_03535	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HVX74_03550	COG4991	sh3 domain protein
HVX74_03555	COG3025	triphosphatase activity
HVX74_03575	COG2268	Band 7 protein
HVX74_03580	COG1585	Membrane protein implicated in regulation of membrane protease activity
HVX74_03600	COG3539	Fimbrial protein
HVX74_03605	COG3121	Chaperone
HVX74_03610	COG3188	usher protein
HVX74_03615	COG3539	Fimbrial protein
HVX74_03630	COG3384	dioxygenase
HVX74_03635	COG0754	glutathionylspermidine amidase activity
HVX74_03645	COG1538	Outer membrane efflux protein
HVX74_03650	COG0494	nUDIX hydrolase
HVX74_03655	COG3151	Protein conserved in bacteria
HVX74_03660	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HVX74_03665	COG3150	esterase
HVX74_03670	COG0187	DNA topoisomerase II activity
HVX74_03690	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HVX74_03710	COG2211	Major facilitator Superfamily
HVX74_03715	COG4774	siderophore transport
HVX74_03720	COG1120	ATPase activity
HVX74_03725	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HVX74_03730	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HVX74_03740	COG1737	Transcriptional regulator
HVX74_03745	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
HVX74_03750	COG2249	NAD(P)H dehydrogenase (quinone) activity
HVX74_03755	COG0642	Histidine kinase
HVX74_03760	COG0745	RESPONSE REGULATOR receiver
HVX74_03765	COG3111	PFAM Bacterial OB fold (BOF) protein
HVX74_03770	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
HVX74_03775	COG4166	transmembrane transport
HVX74_03780	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HVX74_03785	COG0204	Acyl-transferase
HVX74_03790	COG2132	Multicopper oxidase
HVX74_03810	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
HVX74_03815	COG1063	alcohol dehydrogenase
HVX74_03820	COG0246	Mannitol dehydrogenase
HVX74_03825	COG2186	Transcriptional regulator
HVX74_03830	COG1032	radical SAM domain protein
HVX74_03835	COG4238	major outer membrane lipoprotein
HVX74_03845	COG0656	L-ascorbic acid biosynthetic process
HVX74_03850	COG1979	alcohol dehydrogenase
HVX74_03855	COG2207	Transcriptional regulator
HVX74_03860	COG0586	Pfam SNARE associated Golgi protein
HVX74_03865	COG0626	cystathionine gamma-synthase activity
HVX74_03870	COG0811	peptide transport
HVX74_03875	COG0848	biopolymer transport protein
HVX74_03880	COG1028	Short-chain dehydrogenase reductase Sdr
HVX74_03890	COG0667	Aldo Keto reductase
HVX74_03905	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
HVX74_03910	COG0437	4 iron, 4 sulfur cluster binding
HVX74_03915	COG5557	Pfam Polysulphide reductase, NrfD
HVX74_03920	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
HVX74_03925	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
HVX74_03930	COG1773	rubredoxin
HVX74_03935	COG0375	protein maturation
HVX74_03940	COG0298	carbon dioxide binding
HVX74_03945	COG0625	glutathione transferase activity
HVX74_03950	COG0754	glutathionylspermidine amidase activity
HVX74_03955	COG0306	phosphate transporter
HVX74_03960	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HVX74_03965	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HVX74_03970	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HVX74_03975	COG2244	polysaccharide biosynthetic process
HVX74_03985	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
HVX74_03990	COG0795	lipopolysaccharide-transporting ATPase activity
HVX74_04005	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HVX74_04015	COG0318	PFAM AMP-dependent synthetase and ligase
HVX74_04020	COG0456	acetyltransferase
HVX74_04025	COG2186	Transcriptional regulator
HVX74_04030	COG0277	FAD linked oxidase domain protein
HVX74_04035	COG0277	FAD linked oxidase domain protein
HVX74_04040	COG0247	lactate metabolic process
HVX74_04045	COG3193	protein, possibly involved in utilization of glycolate and propanediol
HVX74_04050	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
HVX74_04055	COG1620	l-lactate permease
HVX74_04060	COG3064	Membrane
HVX74_04065	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
HVX74_04085	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HVX74_04090	COG1459	type II secretion system
HVX74_04095	COG2165	general secretion pathway protein
HVX74_04110	COG4795	General secretion pathway protein
HVX74_04125	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
HVX74_04135	COG1811	Na channel or pump
HVX74_04140	COG1982	Orn Lys Arg decarboxylase major
HVX74_04145	COG2211	Major facilitator Superfamily
HVX74_04160	COG1194	a g-specific adenine glycosylase
HVX74_04170	COG3171	Protein conserved in bacteria
HVX74_04180	COG0252	asparaginase activity
HVX74_04195	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
HVX74_04200	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HVX74_04205	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HVX74_04210	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HVX74_04220	COG0762	integral membrane protein
HVX74_04225	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HVX74_04230	COG2805	Type II/IV secretion system protein
HVX74_04245	COG0189	ligase activity
HVX74_04250	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HVX74_04255	COG2356	endonuclease I
HVX74_04265	COG2814	Major facilitator Superfamily
HVX74_04285	COG1166	arginine decarboxylase activity
HVX74_04300	COG0501	Belongs to the peptidase M48B family
HVX74_04305	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HVX74_04310	COG0330	HflC and HflK could
HVX74_04315	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HVX74_04320	COG2213	PTS system mannitol-specific
HVX74_04325	COG1063	alcohol dehydrogenase
HVX74_04330	COG1494	fructose-1,6-bisphosphatase
HVX74_04340	COG1072	(Pantothenic acid kinase))
HVX74_04355	COG0191	fructose-bisphosphate aldolase activity
HVX74_04360	COG0668	transmembrane transport
HVX74_04365	COG1279	arginine transmembrane transporter activity
HVX74_04370	COG2968	Membrane
HVX74_04375	COG0583	DNA-binding transcription factor activity
HVX74_04380	COG0427	acetyl-CoA hydrolase
HVX74_04385	COG1024	Enoyl-CoA hydratase
HVX74_04390	COG1703	isobutyryl-CoA mutase activity
HVX74_04395	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HVX74_04395	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HVX74_04410	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HVX74_04420	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HVX74_04440	COG0006	proline dipeptidase activity
HVX74_04445	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HVX74_04450	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HVX74_04475	COG2723	6-phospho-beta-galactosidase activity
HVX74_04485	COG1272	protein, Hemolysin III
HVX74_04495	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
HVX74_04505	COG0716	FMN binding
HVX74_04510	COG4974	Belongs to the 'phage' integrase family
HVX74_04515	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HVX74_04520	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HVX74_04530	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HVX74_04550	COG2233	PERMEase
HVX74_04560	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HVX74_04565	COG2252	PERMEase
HVX74_04570	COG0402	S-adenosylhomocysteine deaminase activity
HVX74_04575	COG2233	PERMEase
HVX74_04580	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HVX74_04580	COG2080	2 iron, 2 sulfur cluster binding
HVX74_04585	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
HVX74_04590	COG0402	S-adenosylhomocysteine deaminase activity
HVX74_04595	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HVX74_04595	COG0493	'glutamate synthase
HVX74_04600	COG2068	MobA-Related Protein
HVX74_04605	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HVX74_04610	COG3608	succinylglutamate desuccinylase aspartoacylase
HVX74_04610	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
HVX74_04615	COG0549	Belongs to the carbamate kinase family
HVX74_04625	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HVX74_04630	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HVX74_04635	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HVX74_04645	COG2080	2 iron, 2 sulfur cluster binding
HVX74_04650	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
HVX74_04655	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HVX74_04660	COG4942	peptidase
HVX74_04670	COG0814	amino acid
HVX74_04675	COG0183	Belongs to the thiolase family
HVX74_04685	COG1028	Short-chain dehydrogenase reductase Sdr
HVX74_04690	COG2814	Major facilitator Superfamily
HVX74_04695	COG1794	racemase activity, acting on amino acids and derivatives
HVX74_04700	COG0583	DNA-binding transcription factor activity
HVX74_04710	COG1609	Transcriptional regulator
HVX74_04730	COG0667	Aldo Keto reductase
HVX74_04740	COG0861	Integral membrane protein TerC family
HVX74_04755	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
HVX74_04770	COG2165	general secretion pathway protein
HVX74_04775	COG4795	General secretion pathway protein
HVX74_04785	COG4967	type IV pilus modification protein PilV
HVX74_04790	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
HVX74_04800	COG1074	ATP-dependent DNA helicase activity
HVX74_04805	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HVX74_04810	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
HVX74_04810	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HVX74_04815	COG0860	N-Acetylmuramoyl-L-alanine amidase
HVX74_04835	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
HVX74_04840	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HVX74_04845	COG2166	iron-sulfur cluster assembly
HVX74_04850	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HVX74_04860	COG0583	DNA-binding transcription factor activity
HVX74_04865	COG2363	Small membrane protein
HVX74_04875	COG1349	DNA-binding transcription factor activity
HVX74_04885	COG1070	Carbohydrate kinase
HVX74_04895	COG0738	Major facilitator superfamily
HVX74_04900	COG0235	Class ii aldolase
HVX74_04905	COG1454	alcohol dehydrogenase
HVX74_04915	COG1760	l-serine dehydratase
HVX74_04920	COG0814	amino acid
HVX74_04925	COG1611	Belongs to the LOG family
HVX74_04940	COG3098	single-species biofilm formation
HVX74_04945	COG0564	pseudouridine synthase activity
HVX74_04950	COG0716	FMN binding
HVX74_04955	COG2271	Major facilitator Superfamily
HVX74_04960	COG4948	Mandelate Racemase Muconate Lactonizing
HVX74_04965	COG4948	Mandelate Racemase Muconate Lactonizing
HVX74_04970	COG3850	Histidine kinase
HVX74_04970	COG3437	response regulator, receiver
HVX74_04970	COG2205	protein histidine kinase activity
HVX74_04970	COG4999	Histidine kinase
HVX74_04980	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HVX74_04985	COG2336	PFAM SpoVT AbrB
HVX74_04990	COG2337	Toxic component of a toxin-antitoxin (TA) module
HVX74_04995	COG3956	TIGRFAM MazG family protein
HVX74_05010	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
HVX74_05020	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
HVX74_05030	COG0602	queuosine metabolic process
HVX74_05035	COG1070	Carbohydrate kinase
HVX74_05040	COG2223	nitrite transmembrane transporter activity
HVX74_05045	COG1028	Short-chain dehydrogenase reductase Sdr
HVX74_05050	COG0277	FAD linked oxidase domain protein
HVX74_05055	COG0477	Major facilitator Superfamily
HVX74_05060	COG2086	electron transfer activity
HVX74_05065	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
HVX74_05070	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
HVX74_05075	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
HVX74_05080	COG0644	oxidoreductase
HVX74_05085	COG0720	synthase
HVX74_05110	COG1203	CRISPR-associated helicase, Cas3
HVX74_05125	COG1857	crispr-associated protein
HVX74_05140	COG1518	maintenance of DNA repeat elements
HVX74_05145	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HVX74_05150	COG2234	aminopeptidase activity
HVX74_05190	COG0585	pseudouridine synthase activity
HVX74_05205	COG4942	peptidase
HVX74_05205	COG1388	LysM domain
HVX74_05210	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HVX74_05220	COG0163	prenyltransferase activity
HVX74_05225	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HVX74_05235	COG2610	gluconate transmembrane transporter activity
HVX74_05240	COG3622	Belongs to the hyi family
HVX74_05245	COG0235	Class ii aldolase
HVX74_05250	COG3395	kinase activity
HVX74_05255	COG2084	Dehydrogenase
HVX74_05260	COG1349	DNA-binding transcription factor activity
HVX74_05265	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HVX74_05270	COG0249	that it carries out the mismatch recognition step. This protein has a weak ATPase activity
HVX74_05285	COG3604	Transcriptional regulator
HVX74_05290	COG0309	Hydrogenase expression formation protein (HypE)
HVX74_05295	COG0409	Hydrogenase expression formation protein
HVX74_05300	COG0298	carbon dioxide binding
HVX74_05305	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
HVX74_05310	COG0375	protein maturation
HVX74_05320	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HVX74_05325	COG0651	ATP synthesis coupled electron transport
HVX74_05330	COG0650	Formate hydrogenlyase subunit 4
HVX74_05335	COG3261	NADH dehydrogenase
HVX74_05335	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
HVX74_05340	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HVX74_05345	COG3260	NADH ubiquinone oxidoreductase 20
HVX74_05355	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
HVX74_05365	COG5499	transcription regulator containing HTH domain
HVX74_05370	COG2723	6-phospho-beta-galactosidase activity
HVX74_05375	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HVX74_05375	COG1263	PTS System
HVX74_05380	COG1609	Transcriptional regulator
HVX74_05385	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HVX74_05390	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
HVX74_05415	COG1349	DNA-binding transcription factor activity
HVX74_05420	COG4578	phosphoenolpyruvate-dependent sugar phosphotransferase system
HVX74_05425	COG1028	Short-chain dehydrogenase reductase Sdr
HVX74_05435	COG3732	PTS system glucitol sorbitol-specific
HVX74_05440	COG3730	PTS system glucitol sorbitol-specific
HVX74_05445	COG2951	lytic endotransglycosylase activity
HVX74_05450	COG1546	Belongs to the CinA family
HVX74_05470	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
HVX74_05500	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HVX74_05505	COG1238	metal cluster binding
HVX74_05530	COG2814	Major facilitator Superfamily
HVX74_05535	COG1566	PFAM secretion protein HlyD family protein
HVX74_05540	COG1846	Transcriptional regulator
HVX74_05550	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
HVX74_05555	COG2814	Major facilitator Superfamily
HVX74_05560	COG2113	Glycine betaine
HVX74_05565	COG4176	ABC-type proline glycine betaine transport system permease component
HVX74_05570	COG4175	Glycine betaine
HVX74_05575	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HVX74_05580	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HVX74_05590	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HVX74_05595	COG4575	ribosome binding
HVX74_05610	COG2916	Histone family protein nucleoid-structuring protein H-NS
HVX74_05615	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HVX74_05620	COG0640	Transcriptional regulator
HVX74_05625	COG0401	homolog of Blt101
HVX74_05630	COG1652	LysM domain
HVX74_05635	COG1802	Transcriptional regulator
HVX74_05640	COG1113	amino acid transport
HVX74_05645	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HVX74_05650	COG1012	belongs to the aldehyde dehydrogenase family
HVX74_05655	COG0579	oxidoreductase
HVX74_05670	COG1204	response to ionizing radiation
HVX74_05710	COG2003	Belongs to the UPF0758 family
HVX74_05735	COG3596	GTP binding
HVX74_05760	COG4983	Phage plasmid primase, P4 family domain protein
HVX74_05765	COG3311	Transcriptional regulator
HVX74_05775	COG0582	viral genome integration into host DNA
HVX74_05790	COG2867	negative regulation of translational initiation
HVX74_05800	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HVX74_05805	COG0497	DNA recombination
HVX74_05820	COG4536	flavin adenine dinucleotide binding
HVX74_05825	COG4137	Cytochrome C assembly protein
HVX74_05830	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HVX74_05855	COG2885	chlorophyll binding
HVX74_05860	COG2199	diguanylate cyclase activity
HVX74_05875	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HVX74_05880	COG1605	Chorismate mutase
HVX74_05880	COG0287	Prephenate dehydrogenase
HVX74_05885	COG0077	Prephenate dehydratase
HVX74_05885	COG1605	Chorismate mutase
HVX74_05895	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HVX74_05905	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HVX74_05910	COG0564	pseudouridine synthase activity
HVX74_05920	COG0542	response to heat
HVX74_05945	COG0477	Major facilitator Superfamily
HVX74_05950	COG5544	Lipoprotein
HVX74_05955	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HVX74_05960	COG1042	CoA-binding domain protein
HVX74_05960	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HVX74_05960	COG0045	succinate-CoA ligase (ADP-forming) activity
HVX74_05970	COG3118	belongs to the thioredoxin family
HVX74_05975	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HVX74_05995	COG0583	DNA-binding transcription factor activity
HVX74_06000	COG0513	Belongs to the DEAD box helicase family
HVX74_06010	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HVX74_06020	COG1595	DNA-templated transcription, initiation
HVX74_06025	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
HVX74_06030	COG3026	antisigma factor binding
HVX74_06035	COG3086	response to oxidative stress
HVX74_06045	COG0681	Belongs to the peptidase S26 family
HVX74_06065	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
HVX74_06080	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HVX74_06085	COG1737	Transcriptional regulator
HVX74_06090	COG0560	Phosphoserine phosphatase
HVX74_06095	COG0590	tRNA wobble adenosine to inosine editing
HVX74_06105	COG0047	phosphoribosylformylglycinamidine synthase activity
HVX74_06105	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HVX74_06110	COG2205	protein histidine kinase activity
HVX74_06115	COG3170	Tfp pilus assembly protein FimV
HVX74_06120	COG2204	response regulator
HVX74_06125	COG0347	Belongs to the P(II) protein family
HVX74_06130	COG1017	nitric oxide dioxygenase activity
HVX74_06130	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HVX74_06140	COG1940	carbohydrate kinase activity
HVX74_06145	COG0457	Tetratricopeptide repeat
HVX74_06150	COG1879	ABC-type sugar transport system periplasmic component
HVX74_06155	COG1129	ABC transporter
HVX74_06160	COG1172	Belongs to the binding-protein-dependent transport system permease family
HVX74_06165	COG1063	alcohol dehydrogenase
HVX74_06170	COG2017	converts alpha-aldose to the beta-anomer
HVX74_06175	COG2259	Doxx family
HVX74_06200	COG4638	Rieske (2fe-2S)
HVX74_06205	COG0583	DNA-binding transcription factor activity
HVX74_06210	COG2814	Major facilitator Superfamily
HVX74_06215	COG3711	transcriptional antiterminator
HVX74_06220	COG1073	alpha beta
HVX74_06225	COG0483	inositol monophosphate 1-phosphatase activity
HVX74_06245	COG0822	iron-sulfur transferase activity
HVX74_06265	COG0633	Ferredoxin
HVX74_06270	COG2975	iron-sulfur cluster assembly
HVX74_06290	COG2897	thiosulfate sulfurtransferase activity
HVX74_06295	COG2373	Large extracellular alpha-helical protein
HVX74_06300	COG4953	penicillin-binding protein 1C
HVX74_06330	COG2976	Protein conserved in bacteria
HVX74_06345	COG1645	bacterial-type flagellum-dependent swarming motility
HVX74_06370	COG0516	GMP reductase activity
HVX74_06370	COG0517	IMP dehydrogenase activity
HVX74_06410	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HVX74_06505	COG3728	DNA packaging
HVX74_06505	COG5484	DNA packaging
HVX74_06635	COG3179	chitinase
HVX74_06650	COG3133	Outer membrane lipoprotein
HVX74_06665	COG2200	EAL domain
HVX74_06670	COG0248	Ppx GppA phosphatase
HVX74_06675	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
HVX74_06680	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HVX74_06695	COG2233	PERMEase
HVX74_06705	COG1393	Belongs to the ArsC family
HVX74_06710	COG4783	chaperone-mediated protein folding
HVX74_06715	COG0628	permease
HVX74_06720	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HVX74_06725	COG2716	regulation of RNA biosynthetic process
HVX74_06735	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
HVX74_06745	COG2321	neutral zinc metallopeptidase
HVX74_06755	COG0400	carboxylic ester hydrolase activity
HVX74_06770	COG1393	Belongs to the ArsC family
HVX74_06780	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HVX74_06785	COG3850	Histidine kinase
HVX74_06790	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HVX74_06790	COG0493	'glutamate synthase
HVX74_06800	COG5342	invasion associated locus B
HVX74_06805	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HVX74_06810	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HVX74_06815	COG0280	phosphate acetyltransferase
HVX74_06815	COG0281	malic enzyme
HVX74_06820	COG4810	utilization protein
HVX74_06825	COG4917	ethanolamine utilization protein
HVX74_06830	COG4766	ethanolamine catabolic process
HVX74_06835	COG4812	Cobalamin adenosyltransferase
HVX74_06840	COG0280	phosphate acetyltransferase
HVX74_06845	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
HVX74_06850	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
HVX74_06855	COG1012	belongs to the aldehyde dehydrogenase family
HVX74_06860	COG4820	ethanolamine utilization protein (EutJ)
HVX74_06865	COG1454	alcohol dehydrogenase
HVX74_06870	COG3192	ethanolamine utilization protein
HVX74_06875	COG4819	ethanolamine utilization protein
HVX74_06880	COG4303	Ethanolamine ammonia lyase large subunit
HVX74_06890	COG4816	utilization protein
HVX74_06895	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
HVX74_06900	COG2207	Transcriptional regulator
HVX74_06910	COG0860	N-Acetylmuramoyl-L-alanine amidase
HVX74_06930	COG2837	iron assimilation
HVX74_06935	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HVX74_06935	COG1263	PTS System
HVX74_06950	COG1028	Short-chain dehydrogenase reductase Sdr
HVX74_06955	COG4150	thiosulfate binding
HVX74_06960	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
HVX74_06965	COG4208	sulfate ABC transporter
HVX74_06970	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
HVX74_06975	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HVX74_06980	COG3831	ATPase activity
HVX74_06980	COG4884	unkown
HVX74_06995	COG2190	(PTS) system
HVX74_07000	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HVX74_07005	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HVX74_07010	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HVX74_07030	COG3530	Putative quorum-sensing-regulated virulence factor
HVX74_07035	COG0385	Bile acid
HVX74_07040	COG0583	DNA-binding transcription factor activity
HVX74_07050	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
HVX74_07055	COG2211	Major facilitator Superfamily
HVX74_07065	COG0583	DNA-binding transcription factor activity
HVX74_07095	COG3415	Transposase
HVX74_07100	COG3415	Transposase
HVX74_07115	COG2199	diguanylate cyclase activity
HVX74_07115	COG2200	EAL domain
HVX74_07120	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HVX74_07145	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HVX74_07150	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HVX74_07155	COG0006	proline dipeptidase activity
HVX74_07160	COG1363	Peptidase, m42
HVX74_07165	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HVX74_07165	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HVX74_07165	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HVX74_07170	COG2207	Transcriptional regulator
HVX74_07175	COG3279	Response regulator of the LytR AlgR family
HVX74_07180	COG3275	phosphorelay sensor kinase activity
HVX74_07185	COG0436	Aminotransferase
HVX74_07195	COG1560	Kdo2-lipid A biosynthetic process
HVX74_07220	COG0028	Belongs to the TPP enzyme family
HVX74_07225	COG0679	Auxin Efflux Carrier
HVX74_07230	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HVX74_07235	COG0784	Response regulator, receiver
HVX74_07235	COG2205	protein histidine kinase activity
HVX74_07235	COG2198	Histidine kinase
HVX74_07235	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HVX74_07240	COG2197	response regulator
HVX74_07245	COG1566	PFAM secretion protein HlyD family protein
HVX74_07250	COG0477	Major facilitator Superfamily
HVX74_07295	COG2116	formate transmembrane transporter activity
HVX74_07300	COG2853	Lipoprotein
HVX74_07305	COG2067	long-chain fatty acid transport protein
HVX74_07310	COG3691	Protein conserved in bacteria
HVX74_07325	COG2062	phosphohistidine phosphatase, SixA
HVX74_07330	COG3539	Fimbrial protein
HVX74_07365	COG0730	response to heat
HVX74_07370	COG3101	peptidyl-lysine hydroxylation
HVX74_07385	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HVX74_07390	COG2814	Major facilitator Superfamily
HVX74_07405	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HVX74_07415	COG0586	Pfam SNARE associated Golgi protein
HVX74_07425	COG0285	dihydrofolate synthase activity
HVX74_07430	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
HVX74_07435	COG1286	toxin biosynthetic process
HVX74_07440	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HVX74_07445	COG0163	prenyltransferase activity
HVX74_07450	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HVX74_07455	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HVX74_07460	COG4215	(ABC) transporter
HVX74_07465	COG4160	amino acid transport
HVX74_07470	COG4598	ABC transporter
HVX74_07475	COG5464	transposase or invertase
HVX74_07480	COG1090	epimerase
HVX74_07485	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HVX74_07490	COG0625	glutathione transferase activity
HVX74_07495	COG0625	glutathione transferase activity
HVX74_07500	COG0622	Phosphoesterase
HVX74_07505	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
HVX74_07510	COG1288	antiporter activity
HVX74_07515	COG0857	belongs to the CobB CobQ family
HVX74_07515	COG0280	phosphate acetyltransferase
HVX74_07520	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HVX74_07535	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HVX74_07540	COG0471	metal ion transport
HVX74_07540	COG0490	domain, Protein
HVX74_07550	COG0436	Aminotransferase
HVX74_07555	COG0583	DNA-binding transcription factor activity
HVX74_07575	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
HVX74_07580	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
HVX74_07585	COG1034	ATP synthesis coupled electron transport
HVX74_07600	COG0839	Belongs to the complex I subunit 6 family
HVX74_07610	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HVX74_07615	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HVX74_07630	COG2234	aminopeptidase activity
HVX74_07635	COG2304	oxidoreductase activity
HVX74_07645	COG2153	protein acetylation
HVX74_07650	COG4575	ribosome binding
HVX74_07655	COG1169	isochorismate synthase
HVX74_07670	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
HVX74_07680	COG0318	PFAM AMP-dependent synthetase and ligase
HVX74_07745	COG1414	Transcriptional regulator
HVX74_07755	COG2271	Major facilitator Superfamily
HVX74_07765	COG5464	transposase or invertase
HVX74_07770	COG0247	lactate metabolic process
HVX74_07780	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HVX74_07785	COG2271	Major facilitator Superfamily
HVX74_07790	COG0584	glycerophosphoryl diester phosphodiesterase
HVX74_07795	COG0583	DNA-binding transcription factor activity
HVX74_07800	COG2814	Major facilitator Superfamily
HVX74_07805	COG3642	lipopolysaccharide core region biosynthetic process
HVX74_07810	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HVX74_07815	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HVX74_07820	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HVX74_07825	COG3468	outer membrane autotransporter barrel domain protein
HVX74_07835	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HVX74_07840	COG4685	Uncharacterized protein conserved in bacteria (DUF2138)
HVX74_07845	COG3234	Protein of unknown function (DUF1175)
HVX74_07850	COG2373	Large extracellular alpha-helical protein
HVX74_07855	COG5445	Predicted secreted protein (DUF2300)
HVX74_07860	COG4676	Protein conserved in bacteria
HVX74_07865	COG0183	Belongs to the thiolase family
HVX74_07870	COG2031	fatty acid transporter
HVX74_07875	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HVX74_07880	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HVX74_07885	COG2204	response regulator
HVX74_07890	COG3852	Histidine kinase
HVX74_07895	COG2205	protein histidine kinase activity
HVX74_07895	COG0784	Response regulator, receiver
HVX74_07900	COG2197	response regulator
HVX74_07905	COG0642	Histidine kinase
HVX74_07905	COG2198	Histidine kinase
HVX74_07910	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HVX74_07915	COG1477	protein flavinylation
HVX74_07920	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HVX74_07920	COG2169	Transcriptional regulator
HVX74_07925	COG3145	DNA-N1-methyladenine dioxygenase activity
HVX74_07930	COG4615	Cyclic peptide transporter
HVX74_07945	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HVX74_07945	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
HVX74_07950	COG3062	negative regulation of establishment of protein localization
HVX74_07960	COG0437	4 iron, 4 sulfur cluster binding
HVX74_07965	COG0348	domain, Protein
HVX74_07970	COG3043	anaerobic respiration
HVX74_07975	COG3005	denitrification pathway
HVX74_07985	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HVX74_07990	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HVX74_07995	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HVX74_08005	COG1138	Cytochrome C-type biogenesis protein
HVX74_08010	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HVX74_08015	COG4235	cytochrome complex assembly
HVX74_08015	COG3088	subunit of a heme lyase
HVX74_08020	COG2197	response regulator
HVX74_08035	COG3083	sulfuric ester hydrolase activity
HVX74_08055	COG1061	Type III restriction enzyme res subunit
HVX74_08060	COG1187	pseudouridine synthase activity
HVX74_08065	COG2814	Major facilitator Superfamily
HVX74_08075	COG4172	Belongs to the ABC transporter superfamily
HVX74_08080	COG4239	(ABC) transporter, permease
HVX74_08085	COG4174	ABC transporter (Permease)
HVX74_08090	COG4166	transmembrane transport
HVX74_08095	COG2200	EAL domain
HVX74_08100	COG0791	NLP P60 protein
HVX74_08105	COG0671	phosphoesterase, PA-phosphatase related
HVX74_08110	COG0523	cobalamin synthesis protein
HVX74_08115	COG0246	Mannitol dehydrogenase
HVX74_08130	COG2814	Major facilitator Superfamily
HVX74_08135	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HVX74_08135	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HVX74_08140	COG1105	Belongs to the carbohydrate kinase PfkB family
HVX74_08145	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HVX74_08145	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
HVX74_08145	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HVX74_08150	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HVX74_08155	COG2313	pseudouridylate synthase activity
HVX74_08160	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HVX74_08165	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HVX74_08175	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HVX74_08180	COG1522	sequence-specific DNA binding
HVX74_08180	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HVX74_08190	COG2855	membrane
HVX74_08195	COG0583	DNA-binding transcription factor activity
HVX74_08200	COG0833	amino acid
HVX74_08205	COG4771	TonB-dependent receptor
HVX74_08210	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
HVX74_08220	COG2311	Membrane
HVX74_08225	COG1609	Transcriptional regulator
HVX74_08230	COG1879	ABC-type sugar transport system periplasmic component
HVX74_08235	COG1129	ABC transporter
HVX74_08240	COG4211	Belongs to the binding-protein-dependent transport system permease family
HVX74_08245	COG0167	dihydroorotate dehydrogenase activity
HVX74_08245	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
HVX74_08250	COG0493	'glutamate synthase
HVX74_08260	COG2949	membrane
HVX74_08270	COG1346	cytolysis
HVX74_08285	COG2271	Major facilitator Superfamily
HVX74_08300	COG0625	glutathione transferase activity
HVX74_08305	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HVX74_08310	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HVX74_08325	COG1028	Short-chain dehydrogenase reductase Sdr
HVX74_08330	COG0586	Pfam SNARE associated Golgi protein
HVX74_08340	COG1686	Belongs to the peptidase S11 family
HVX74_08345	COG0277	FAD linked oxidase domain protein
HVX74_08350	COG1472	Belongs to the glycosyl hydrolase 3 family
HVX74_08355	COG1732	Glycine betaine
HVX74_08360	COG1174	glycine betaine transport
HVX74_08365	COG1125	glycine betaine transport
HVX74_08370	COG1174	glycine betaine transport
HVX74_08380	COG0789	Transcriptional regulator
HVX74_08385	COG3275	phosphorelay sensor kinase activity
HVX74_08390	COG3279	Response regulator of the LytR AlgR family
HVX74_08395	COG4807	Protein conserved in bacteria
HVX74_08400	COG4808	Protein conserved in bacteria
HVX74_08405	COG4715	Zinc finger, swim domain protein
HVX74_08410	COG3552	Protein containing von Willebrand factor type A (VWA) domain
HVX74_08415	COG2425	protein containing a von Willebrand factor type A (vWA) domain
HVX74_08420	COG0714	Associated with various cellular activities
HVX74_08430	COG3831	ATPase activity
HVX74_08435	COG3831	ATPase activity
HVX74_08440	COG3831	ATPase activity
HVX74_08445	COG3831	ATPase activity
HVX74_08455	COG0489	protein tyrosine kinase activity
HVX74_08465	COG3539	Fimbrial protein
HVX74_08470	COG3121	Chaperone
HVX74_08475	COG3188	usher protein
HVX74_08480	COG3539	Fimbrial protein
HVX74_08485	COG5455	response to cobalt ion
HVX74_08490	COG2215	Belongs to the NiCoT transporter (TC 2.A.52) family
HVX74_08505	COG0351	phosphomethylpyrimidine kinase
HVX74_08510	COG3757	hydrolase, family 25
HVX74_08515	COG2188	Transcriptional regulator
HVX74_08520	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HVX74_08525	COG1397	ADP-ribosylglycohydrolase
HVX74_08530	COG2211	Major facilitator Superfamily
HVX74_08535	COG1830	Aldolase
HVX74_08550	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HVX74_08555	COG3414	Phosphotransferase system galactitol-specific IIB component
HVX74_08560	COG3775	system Galactitol-specific IIC component
HVX74_08565	COG1063	alcohol dehydrogenase
HVX74_08585	COG4974	Belongs to the 'phage' integrase family
HVX74_08640	COG0631	protein serine/threonine phosphatase activity
HVX74_08645	COG4695	Portal protein
HVX74_08735	COG5301	cellulose 1,4-beta-cellobiosidase activity
HVX74_08810	COG0745	RESPONSE REGULATOR receiver
HVX74_08815	COG2205	protein histidine kinase activity
HVX74_08850	COG4245	von Willebrand factor, type A
HVX74_08855	COG0631	protein serine/threonine phosphatase activity
HVX74_08860	COG3779	Protein conserved in bacteria
HVX74_08865	COG4248	protein with protein kinase and helix-hairpin-helix DNA-binding domains
HVX74_08870	COG0443	Heat shock 70 kDa protein
HVX74_08875	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
HVX74_08880	COG3447	MASE1 domain protein
HVX74_08880	COG5002	protein histidine kinase activity
HVX74_08880	COG5001	Diguanylate cyclase
HVX74_08885	COG0572	uridine kinase
HVX74_08895	COG2982	Protein involved in outer membrane biogenesis
HVX74_08900	COG1253	flavin adenine dinucleotide binding
HVX74_08910	COG1596	polysaccharide export
HVX74_08915	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HVX74_08920	COG0489	protein tyrosine kinase activity
HVX74_08920	COG3206	protein involved in exopolysaccharide biosynthesis
HVX74_08925	COG0463	Glycosyl transferase, family 2
HVX74_08930	COG1045	serine acetyltransferase
HVX74_08935	COG0438	transferase activity, transferring glycosyl groups
HVX74_08945	COG1216	Glycosyl transferase, family 2
HVX74_08950	COG0110	maltose O-acetyltransferase activity
HVX74_08955	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
HVX74_08960	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HVX74_08965	COG1051	belongs to the nudix hydrolase family
HVX74_08970	COG0297	glycogen (starch) synthase activity
HVX74_08975	COG0662	Cupin 2, conserved barrel domain protein
HVX74_08975	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
HVX74_08980	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HVX74_08985	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HVX74_08990	COG2244	polysaccharide biosynthetic process
HVX74_08995	COG2327	Polysaccharide pyruvyl transferase
HVX74_09000	COG0438	transferase activity, transferring glycosyl groups
HVX74_09010	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HVX74_09015	COG1088	dTDP-glucose 4,6-dehydratase activity
HVX74_09020	COG1091	dTDP-4-dehydrorhamnose reductase activity
HVX74_09025	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
HVX74_09045	COG2244	polysaccharide biosynthetic process
HVX74_09080	COG5433	transposase activity
HVX74_09095	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
HVX74_09100	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
HVX74_09125	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HVX74_09130	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HVX74_09130	COG0131	Imidazoleglycerol-phosphate dehydratase
HVX74_09155	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HVX74_09160	COG0583	DNA-binding transcription factor activity
HVX74_09170	COG0531	amino acid
HVX74_09175	COG2925	Exonuclease
HVX74_09180	COG1686	Belongs to the peptidase S11 family
HVX74_09190	COG1289	transmembrane transporter activity
HVX74_09215	COG4656	Part of a membrane complex involved in electron transport
HVX74_09220	COG1012	belongs to the aldehyde dehydrogenase family
HVX74_09220	COG1454	alcohol dehydrogenase
HVX74_09225	COG1012	belongs to the aldehyde dehydrogenase family
HVX74_09315	COG2087	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate
HVX74_09330	COG1376	ErfK ybiS ycfS ynhG family protein
HVX74_09340	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HVX74_09345	COG3414	Phosphotransferase system galactitol-specific IIB component
HVX74_09355	COG0698	ribose 5-phosphate isomerase
HVX74_09360	COG1349	DNA-binding transcription factor activity
HVX74_09370	COG3414	Phosphotransferase system galactitol-specific IIB component
HVX74_09375	COG3775	system Galactitol-specific IIC component
HVX74_09380	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HVX74_09385	COG1028	Short-chain dehydrogenase reductase Sdr
HVX74_09390	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HVX74_09400	COG0583	DNA-binding transcription factor activity
HVX74_09405	COG0583	DNA-binding transcription factor activity
HVX74_09415	COG0534	Mate efflux family protein
HVX74_09425	COG0217	transcriptional regulatory protein
HVX74_09430	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HVX74_09435	COG0477	Major facilitator Superfamily
HVX74_09465	COG3038	cytochrome b561
HVX74_09470	COG3443	Belongs to the bacterial solute-binding protein 9 family
HVX74_09485	COG2351	hydroxyisourate hydrolase activity
HVX74_09490	COG0745	RESPONSE REGULATOR receiver
HVX74_09495	COG2205	protein histidine kinase activity
HVX74_09510	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HVX74_09520	COG1418	mRNA catabolic process
HVX74_09525	COG0270	DNA (cytosine-5-)-methyltransferase activity
HVX74_09530	COG3727	T/G mismatch-specific endonuclease activity
HVX74_09535	COG0697	spore germination
HVX74_09540	COG2354	Protein conserved in bacteria
HVX74_09545	COG5475	Uncharacterized small protein (DUF2158)
HVX74_09570	COG2197	response regulator
HVX74_09575	COG1684	flagellar biosynthetic protein fliR
HVX74_09580	COG1987	bacterial-type flagellum assembly
HVX74_09585	COG1338	Plays a role in the flagellum-specific transport system
HVX74_09590	COG3190	flagellar
HVX74_09595	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HVX74_09600	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HVX74_09605	COG1580	Controls the rotational direction of flagella during chemotaxis
HVX74_09610	COG3144	bacterial-type flagellum assembly
HVX74_09615	COG2882	bacterial-type flagellum organization
HVX74_09620	COG1157	protein secretion by the type III secretion system
HVX74_09625	COG1317	bacterial-type flagellum organization
HVX74_09630	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HVX74_09635	COG1766	The M ring may be actively involved in energy transduction
HVX74_09645	COG0454	-acetyltransferase
HVX74_09650	COG2135	peptidase activity
HVX74_09655	COG0425	Belongs to the sulfur carrier protein TusA family
HVX74_09660	COG2391	methyltransferase activity
HVX74_09670	COG0366	Alpha amylase catalytic
HVX74_09680	COG1516	flagellar protein fliS
HVX74_09685	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
HVX74_09695	COG1191	sigma factor activity
HVX74_09725	COG2197	response regulator
HVX74_09740	COG2197	response regulator
HVX74_09770	COG3012	SEC-C Motif Domain Protein
HVX74_09770	COG3318	Belongs to the UPF0149 family
HVX74_09775	COG0814	amino acid
HVX74_09785	COG1528	Iron-storage protein
HVX74_09805	COG1528	Iron-storage protein
HVX74_09810	COG1879	ABC-type sugar transport system periplasmic component
HVX74_09815	COG1129	ABC transporter
HVX74_09820	COG1172	Belongs to the binding-protein-dependent transport system permease family
HVX74_09825	COG1877	trehalose-phosphatase activity
HVX74_09835	COG0589	response to stress
HVX74_09850	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
HVX74_09855	COG1360	Flagellar Motor Protein
HVX74_09860	COG2198	Histidine kinase
HVX74_09860	COG0643	Histidine kinase
HVX74_09865	COG0835	chemotaxis
HVX74_09870	COG0840	transmembrane signaling receptor activity
HVX74_09875	COG0840	transmembrane signaling receptor activity
HVX74_09880	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
HVX74_09890	COG0745	RESPONSE REGULATOR receiver
HVX74_09895	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
HVX74_09900	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HVX74_09905	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HVX74_09920	COG3102	Protein conserved in bacteria
HVX74_09930	COG3005	denitrification pathway
HVX74_09935	COG0243	molybdopterin cofactor binding
HVX74_09950	COG3788	relative of glutathione S-transferase, MAPEG superfamily
HVX74_09955	COG1801	Protein of unknown function DUF72
HVX74_09960	COG1335	isochorismatase
HVX74_09970	COG0494	nUDIX hydrolase
HVX74_09975	COG0217	transcriptional regulatory protein
HVX74_10005	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HVX74_10015	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
HVX74_10020	COG0739	heme binding
HVX74_10025	COG1560	Kdo2-lipid A biosynthetic process
HVX74_10030	COG0469	pyruvate kinase activity
HVX74_10035	COG1737	Transcriptional regulator
HVX74_10040	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HVX74_10045	COG0129	dihydroxy-acid dehydratase activity
HVX74_10050	COG0800	Aldolase
HVX74_10060	COG3141	response to X-ray
HVX74_10070	COG2979	Protein of unknown function (DUF533)
HVX74_10075	COG1770	oligopeptidase
HVX74_10080	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HVX74_10085	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HVX74_10095	COG2372	response to copper ion
HVX74_10100	COG1276	copper resistance
HVX74_10110	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HVX74_10130	COG3008	intermembrane lipid transfer
HVX74_10135	COG2995	paraquat-inducible protein a
HVX74_10140	COG1956	GAF domain-containing protein
HVX74_10150	COG0793	Belongs to the peptidase S41A family
HVX74_10160	COG2814	Major facilitator Superfamily
HVX74_10165	COG1414	Transcriptional regulator
HVX74_10195	COG2226	methyltransferase
HVX74_10210	COG3716	PTS system mannose fructose sorbose family IID component
HVX74_10215	COG3715	PTS system
HVX74_10220	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HVX74_10220	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HVX74_10225	COG1253	flavin adenine dinucleotide binding
HVX74_10230	COG2200	EAL domain
HVX74_10235	COG1760	l-serine dehydratase
HVX74_10245	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HVX74_10260	COG0251	oxidation-reduction process
HVX74_10265	COG1199	ATP-dependent helicase activity
HVX74_10270	COG1214	PFAM Peptidase M22, glycoprotease
HVX74_10275	COG3065	identical protein binding
HVX74_10280	COG0318	PFAM AMP-dependent synthetase and ligase
HVX74_10285	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
HVX74_10290	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HVX74_10295	COG4638	Rieske (2fe-2S)
HVX74_10300	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HVX74_10305	COG0473	3-isopropylmalate dehydrogenase activity
HVX74_10310	COG0583	DNA-binding transcription factor activity
HVX74_10320	COG3615	Tellurite resistance protein tehB
HVX74_10330	COG2261	transglycosylase associated protein
HVX74_10345	COG2203	Gaf domain
HVX74_10345	COG2199	diguanylate cyclase activity
HVX74_10350	COG3042	response to heat
HVX74_10355	COG3189	MarR family transcriptional regulator
HVX74_10360	COG2807	transmembrane transport
HVX74_10365	COG2207	Transcriptional regulator
HVX74_10380	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HVX74_10385	COG2199	diguanylate cyclase activity
HVX74_10390	COG2199	diguanylate cyclase activity
HVX74_10400	COG2766	serine protein kinase
HVX74_10405	COG3713	MltA-interacting MipA family protein
HVX74_10410	COG0656	L-ascorbic acid biosynthetic process
HVX74_10415	COG0676	glucose-6-phosphate 1-epimerase activity
HVX74_10420	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HVX74_10430	COG3139	Protein of unknown function (DUF1315)
HVX74_10440	COG0191	fructose-bisphosphate aldolase activity
HVX74_10445	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HVX74_10450	COG0667	Aldo Keto reductase
HVX74_10455	COG1349	DNA-binding transcription factor activity
HVX74_10460	COG2814	Major facilitator Superfamily
HVX74_10465	COG1335	isochorismatase
HVX74_10470	COG0252	asparaginase activity
HVX74_10475	COG0616	signal peptide processing
HVX74_10480	COG0778	Nitroreductase
HVX74_10485	COG0709	Synthesizes selenophosphate from selenide and ATP
HVX74_10490	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HVX74_10495	COG0443	Heat shock 70 kDa protein
HVX74_10500	COG0484	heat shock protein binding
HVX74_10505	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HVX74_10515	COG0494	nUDIX hydrolase
HVX74_10520	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HVX74_10525	COG2897	thiosulfate sulfurtransferase activity
HVX74_10530	COG4136	ATPase activity
HVX74_10535	COG4135	transport system, permease component
HVX74_10540	COG4134	Bacterial extracellular solute-binding protein
HVX74_10545	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HVX74_10550	COG0398	Pfam SNARE associated Golgi protein
HVX74_10560	COG0398	Pfam SNARE associated Golgi protein
HVX74_10565	COG0708	Exodeoxyribonuclease III
HVX74_10595	COG3678	ATP-independent chaperone mediated protein folding
HVX74_10605	COG0322	excinuclease ABC activity
HVX74_10615	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HVX74_10620	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HVX74_10625	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HVX74_10630	COG1447	Phosphotransferase system cellobiose-specific component IIA
HVX74_10635	COG1917	Cupin 2, conserved barrel domain protein
HVX74_10635	COG2169	Transcriptional regulator
HVX74_10640	COG1486	melibiose metabolic process
HVX74_10645	COG3394	polysaccharide catabolic process
HVX74_10650	COG0753	catalase activity
HVX74_10670	COG1988	membrane-bound metal-dependent
HVX74_10675	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HVX74_10685	COG3001	Fructosamine kinase
HVX74_10695	COG1105	Belongs to the carbohydrate kinase PfkB family
HVX74_10700	COG3137	Salt-induced outer membrane protein
HVX74_10760	COG0386	Belongs to the glutathione peroxidase family
HVX74_10770	COG0791	NLP P60 protein
HVX74_10775	COG2200	EAL domain
HVX74_10785	COG4256	Hemin uptake protein
HVX74_10790	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HVX74_10800	COG0574	Belongs to the PEP-utilizing enzyme family
HVX74_10800	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HVX74_10805	COG0471	metal ion transport
HVX74_10810	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HVX74_10820	COG1028	Short-chain dehydrogenase reductase Sdr
HVX74_10825	COG0318	PFAM AMP-dependent synthetase and ligase
HVX74_10830	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
HVX74_10835	COG0644	oxidoreductase
HVX74_10840	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
HVX74_10845	COG2086	electron transfer activity
HVX74_10850	COG2207	Transcriptional regulator
HVX74_10850	COG1917	Cupin 2, conserved barrel domain protein
HVX74_10855	COG1960	acyl-CoA dehydrogenase activity
HVX74_10860	COG4670	ketone body catabolic process
HVX74_10875	COG2271	Major facilitator Superfamily
HVX74_10880	COG0738	Major facilitator superfamily
HVX74_10895	COG0628	permease
HVX74_10900	COG0277	FAD linked oxidase domain protein
HVX74_10900	COG0247	lactate metabolic process
HVX74_10905	COG2050	protein possibly involved in aromatic compounds catabolism
HVX74_10915	COG0316	Belongs to the HesB IscA family
HVX74_10920	COG0719	Fe-S assembly protein
HVX74_10925	COG0396	ATPase activity
HVX74_10930	COG0719	Fe-S assembly protein
HVX74_10945	COG1376	ErfK ybiS ycfS ynhG family protein
HVX74_10950	COG4238	major outer membrane lipoprotein
HVX74_10955	COG0469	pyruvate kinase activity
HVX74_10965	COG0437	4 iron, 4 sulfur cluster binding
HVX74_10970	COG2414	aldehyde ferredoxin oxidoreductase
HVX74_10980	COG0437	4 iron, 4 sulfur cluster binding
HVX74_10985	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
HVX74_10995	COG4529	Protein conserved in bacteria
HVX74_11015	COG3468	outer membrane autotransporter barrel domain protein
HVX74_11025	COG0307	riboflavin synthase, alpha
HVX74_11030	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HVX74_11035	COG2814	Major facilitator Superfamily
HVX74_11040	COG0583	DNA-binding transcription factor activity
HVX74_11055	COG2814	Major facilitator Superfamily
HVX74_11060	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HVX74_11065	COG0791	NLP P60 protein
HVX74_11070	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
HVX74_11075	COG1201	RNA secondary structure unwinding
HVX74_11085	COG0346	lactoylglutathione lyase activity
HVX74_11090	COG1902	pentaerythritol trinitrate reductase activity
HVX74_11095	COG1309	transcriptional regulator
HVX74_11100	COG3313	Fe-S protein
HVX74_11105	COG4989	oxidoreductase activity
HVX74_11110	COG2032	superoxide dismutase activity
HVX74_11115	COG1289	transmembrane transporter activity
HVX74_11120	COG1566	PFAM secretion protein HlyD family protein
HVX74_11135	COG3133	Outer membrane lipoprotein
HVX74_11145	COG3895	Periplasmic Protein
HVX74_11160	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
HVX74_11165	COG0625	glutathione transferase activity
HVX74_11170	COG3104	oligopeptide transport
HVX74_11175	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HVX74_11185	COG4659	FMN binding
HVX74_11225	COG0673	inositol 2-dehydrogenase activity
HVX74_11235	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HVX74_11245	COG0582	viral genome integration into host DNA
HVX74_11255	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HVX74_11295	COG1846	Transcriptional regulator
HVX74_11345	COG1403	HNH endonuclease
HVX74_11350	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
HVX74_11420	COG5562	phage envelope protein
HVX74_11425	COG4220	transposase activity
HVX74_11495	COG1196	nuclear chromosome segregation
HVX74_11525	COG5301	cellulose 1,4-beta-cellobiosidase activity
HVX74_11540	COG1609	Transcriptional regulator
HVX74_11545	COG1028	Short-chain dehydrogenase reductase Sdr
HVX74_11550	COG1309	transcriptional regulator
HVX74_11555	COG3250	beta-galactosidase activity
HVX74_11570	COG5339	Protein conserved in bacteria
HVX74_11575	COG1482	cell wall glycoprotein biosynthetic process
HVX74_11580	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
HVX74_11580	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HVX74_11585	COG0114	fumarate hydratase activity
HVX74_11595	COG2205	protein histidine kinase activity
HVX74_11600	COG0745	RESPONSE REGULATOR receiver
HVX74_11605	COG3136	membrane protein required for alginate biosynthesis
HVX74_11615	COG0531	amino acid
HVX74_11625	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
HVX74_11630	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
HVX74_11635	COG0628	permease
HVX74_11650	COG3591	Belongs to the peptidase S1B family
HVX74_11665	COG2814	Major facilitator Superfamily
HVX74_11670	COG0583	DNA-binding transcription factor activity
HVX74_11675	COG1940	carbohydrate kinase activity
HVX74_11680	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HVX74_11690	COG3381	protein complex oligomerization
HVX74_11695	COG3302	dmso reductase anchor subunit
HVX74_11700	COG0437	4 iron, 4 sulfur cluster binding
HVX74_11705	COG0243	molybdopterin cofactor binding
HVX74_11710	COG0243	molybdopterin cofactor binding
HVX74_11725	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HVX74_11740	COG4948	Mandelate Racemase Muconate Lactonizing
HVX74_11745	COG1063	alcohol dehydrogenase
HVX74_11750	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HVX74_11760	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HVX74_11765	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HVX74_11780	COG0246	Mannitol dehydrogenase
HVX74_11790	COG1802	Transcriptional regulator
HVX74_11795	COG4221	oxidoreductase activity
HVX74_11800	COG0339	signal peptide processing
HVX74_11805	COG1546	Belongs to the CinA family
HVX74_11810	COG3111	PFAM Bacterial OB fold (BOF) protein
HVX74_11815	COG3706	GGDEF domain
HVX74_11825	COG2814	Major facilitator Superfamily
HVX74_11830	COG0697	spore germination
HVX74_11835	COG2188	Transcriptional regulator
HVX74_11845	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HVX74_11850	COG1447	Phosphotransferase system cellobiose-specific component IIA
HVX74_11860	COG2723	6-phospho-beta-galactosidase activity
HVX74_11870	COG4977	sequence-specific DNA binding
HVX74_11875	COG1846	Transcriptional regulator
HVX74_11895	COG0583	DNA-binding transcription factor activity
HVX74_11900	COG1012	belongs to the aldehyde dehydrogenase family
HVX74_11905	COG2066	Belongs to the glutaminase family
HVX74_11915	COG2199	diguanylate cyclase activity
HVX74_11925	COG3781	membrane
HVX74_11975	COG1396	sequence-specific DNA binding
HVX74_11980	COG3550	peptidyl-serine autophosphorylation
HVX74_12000	COG3188	usher protein
HVX74_12005	COG3539	Fimbrial protein
HVX74_12010	COG3539	Fimbrial protein
HVX74_12015	COG3539	Fimbrial protein
HVX74_12020	COG0243	molybdopterin cofactor binding
HVX74_12030	COG2207	Transcriptional regulator
HVX74_12035	COG3119	arylsulfatase activity
HVX74_12040	COG0641	radical SAM
HVX74_12050	COG4178	(ABC) transporter
HVX74_12055	COG4771	TonB-dependent receptor
HVX74_12060	COG0612	Peptidase, M16
HVX74_12065	COG0076	glutamate decarboxylase activity
HVX74_12070	COG0531	amino acid
HVX74_12085	COG3706	GGDEF domain
HVX74_12090	COG2202	Pas domain
HVX74_12090	COG2199	diguanylate cyclase activity
HVX74_12090	COG2200	EAL domain
HVX74_12095	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
HVX74_12110	COG4608	Belongs to the ABC transporter superfamily
HVX74_12115	COG1764	response to oxidative stress
HVX74_12135	COG1064	alcohol dehydrogenase
HVX74_12140	COG3093	addiction module antidote protein HigA
HVX74_12145	COG2864	formate dehydrogenase
HVX74_12150	COG0437	4 iron, 4 sulfur cluster binding
HVX74_12160	COG0697	spore germination
HVX74_12170	COG2223	nitrite transmembrane transporter activity
HVX74_12175	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
HVX74_12180	COG1140	nitrate reductase beta subunit
HVX74_12185	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
HVX74_12190	COG2181	nitrate reductase activity
HVX74_12195	COG0384	phenazine biosynthesis protein PhzF
HVX74_12200	COG2162	N-hydroxyarylamine O-acetyltransferase activity
HVX74_12205	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HVX74_12210	COG5433	transposase activity
HVX74_12240	COG3501	Rhs element vgr protein
HVX74_12255	COG1113	amino acid transport
HVX74_12260	COG3391	amine dehydrogenase activity
HVX74_12265	COG4772	TonB-dependent receptor
HVX74_12270	COG1802	Transcriptional regulator
HVX74_12275	COG2130	NADP-dependent
HVX74_12280	COG1247	-acetyltransferase
HVX74_12285	COG3238	Protein conserved in bacteria
HVX74_12315	COG1177	transmembrane transport
HVX74_12320	COG1176	ABC-type spermidine putrescine transport system, permease component I
HVX74_12325	COG3842	ATPase activity
HVX74_12330	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HVX74_12335	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HVX74_12350	COG0826	peptidase U32
HVX74_12355	COG1396	sequence-specific DNA binding
HVX74_12360	COG3135	benzoate transporter
HVX74_12370	COG0500	methyltransferase
HVX74_12375	COG1275	C4-dicarboxylate transporter malic acid transport protein
HVX74_12380	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HVX74_12385	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HVX74_12390	COG2841	Protein conserved in bacteria
HVX74_12400	COG5383	Protein conserved in bacteria
HVX74_12405	COG0583	DNA-binding transcription factor activity
HVX74_12410	COG0840	transmembrane signaling receptor activity
HVX74_12425	COG3038	cytochrome b561
HVX74_12430	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HVX74_12435	COG1012	belongs to the aldehyde dehydrogenase family
HVX74_12440	COG1434	Gram-negative-bacterium-type cell wall biogenesis
HVX74_12455	COG1643	Atp-dependent helicase
HVX74_12465	COG2453	phosphatase
HVX74_12465	COG0671	phosphoesterase, PA-phosphatase related
HVX74_12470	COG2267	carboxylic ester hydrolase activity
HVX74_12475	COG4589	Belongs to the CDS family
HVX74_12480	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HVX74_12490	COG0667	Aldo Keto reductase
HVX74_12505	COG2207	Transcriptional regulator
HVX74_12510	COG3784	Protein of unknown function (DUF1318)
HVX74_12520	COG2911	Protein conserved in bacteria
HVX74_12525	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HVX74_12530	COG3187	Heat shock protein
HVX74_12535	COG3042	response to heat
HVX74_12540	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HVX74_12540	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HVX74_12540	COG0674	pyruvate-flavodoxin oxidoreductase activity
HVX74_12540	COG1013	pyruvate-flavodoxin oxidoreductase activity
HVX74_12545	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HVX74_12550	COG0589	response to stress
HVX74_12560	COG3436	PFAM IS66 Orf2 family protein
HVX74_12565	COG4372	Transposase
HVX74_12575	COG5301	cellulose 1,4-beta-cellobiosidase activity
HVX74_12605	COG1196	nuclear chromosome segregation
HVX74_12690	COG1475	DNA binding
HVX74_12800	COG1846	Transcriptional regulator
HVX74_12805	COG1484	DNA-dependent DNA replication
HVX74_12810	COG3756	Protein conserved in bacteria
HVX74_12825	COG1396	sequence-specific DNA binding
HVX74_12860	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HVX74_12865	COG3723	Recombinational DNA repair protein, rece pathway
HVX74_12885	COG0582	viral genome integration into host DNA
HVX74_12895	COG0513	Belongs to the DEAD box helicase family
HVX74_12905	COG3706	GGDEF domain
HVX74_12910	COG2840	Smr protein MutS2
HVX74_12915	COG0583	DNA-binding transcription factor activity
HVX74_12920	COG1473	amidohydrolase
HVX74_12925	COG1473	amidohydrolase
HVX74_12930	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
HVX74_12935	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HVX74_12940	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HVX74_12945	COG0589	response to stress
HVX74_12950	COG3182	Iron-regulated membrane protein
HVX74_12955	COG0668	transmembrane transport
HVX74_12960	COG4166	transmembrane transport
HVX74_12965	COG2866	Carboxypeptidase
HVX74_12970	COG4948	Mandelate Racemase Muconate Lactonizing
HVX74_12975	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
HVX74_12980	COG3283	Transcriptional regulator of aromatic amino acids metabolism
HVX74_12990	COG3106	COG3106 Predicted ATPase
HVX74_12995	COG1609	Transcriptional regulator
HVX74_13010	COG1175	transmembrane transport
HVX74_13015	COG1653	transport
HVX74_13020	COG0366	Alpha amylase catalytic
HVX74_13025	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HVX74_13035	COG1983	PspC domain protein
HVX74_13045	COG1842	Phage shock protein A
HVX74_13050	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
HVX74_13055	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HVX74_13060	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HVX74_13065	COG1012	belongs to the aldehyde dehydrogenase family
HVX74_13070	COG1396	sequence-specific DNA binding
HVX74_13070	COG1917	Cupin 2, conserved barrel domain protein
HVX74_13075	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
HVX74_13080	COG0174	glutamine synthetase
HVX74_13090	COG0531	amino acid
HVX74_13100	COG4166	transmembrane transport
HVX74_13105	COG4168	peptide transport system, permease
HVX74_13110	COG4171	peptide transport system, permease
HVX74_13115	COG4172	Belongs to the ABC transporter superfamily
HVX74_13120	COG4172	Belongs to the ABC transporter superfamily
HVX74_13130	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HVX74_13135	COG4950	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HVX74_13135	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HVX74_13150	COG5001	Diguanylate cyclase
HVX74_13160	COG1349	DNA-binding transcription factor activity
HVX74_13170	COG0023	Translation Initiation Factor
HVX74_13180	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
HVX74_13185	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
HVX74_13190	COG0671	phosphoesterase, PA-phosphatase related
HVX74_13200	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HVX74_13220	COG0583	DNA-binding transcription factor activity
HVX74_13225	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HVX74_13235	COG0616	signal peptide processing
HVX74_13240	COG1028	Short-chain dehydrogenase reductase Sdr
HVX74_13245	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
HVX74_13250	COG1187	pseudouridine synthase activity
HVX74_13255	COG4907	membrane protein (DUF2207)
HVX74_13260	COG0009	L-threonylcarbamoyladenylate synthase
HVX74_13265	COG0613	PHP domain protein
HVX74_13275	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HVX74_13280	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HVX74_13280	COG0512	Glutamine amidotransferase of anthranilate synthase
HVX74_13285	COG0134	indole-3-glycerol-phosphate synthase activity
HVX74_13285	COG0135	phosphoribosylanthranilate isomerase activity
HVX74_13295	COG0159	tryptophan synthase activity
HVX74_13300	COG3729	General stress protein
HVX74_13305	COG3685	Protein conserved in bacteria
HVX74_13310	COG3685	Protein conserved in bacteria
HVX74_13315	COG3047	cAMP biosynthetic process
HVX74_13335	COG1607	acyl-coa hydrolase
HVX74_13340	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
HVX74_13345	COG2350	Protein conserved in bacteria
HVX74_13350	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HVX74_13370	COG4608	Belongs to the ABC transporter superfamily
HVX74_13375	COG0444	Belongs to the ABC transporter superfamily
HVX74_13380	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HVX74_13385	COG0601	transmembrane transport
HVX74_13390	COG4166	transmembrane transport
HVX74_13400	COG2095	MarC family integral membrane protein
HVX74_13405	COG1454	alcohol dehydrogenase
HVX74_13405	COG1012	belongs to the aldehyde dehydrogenase family
HVX74_13410	COG1435	thymidine kinase activity
HVX74_13420	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HVX74_13425	COG0745	RESPONSE REGULATOR receiver
HVX74_13430	COG1752	Esterase of the alpha-beta hydrolase superfamily
HVX74_13440	COG0788	formyltetrahydrofolate deformylase activity
HVX74_13455	COG2181	nitrate reductase activity
HVX74_13460	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
HVX74_13465	COG1140	nitrate reductase beta subunit
HVX74_13470	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
HVX74_13475	COG2223	nitrite transmembrane transporter activity
HVX74_13480	COG3850	Histidine kinase
HVX74_13485	COG2197	response regulator
HVX74_13490	COG4932	domain protein
HVX74_13495	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
HVX74_13500	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
HVX74_13505	COG4572	Cation transport regulator
HVX74_13510	COG0387	Pfam Sodium calcium exchanger
HVX74_13530	COG2912	Transglutaminase-like superfamily
HVX74_13535	COG3094	Invasion gene expression up-regulator, SirB
HVX74_13540	COG2890	protein-(glutamine-N5) methyltransferase activity
HVX74_13565	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HVX74_13570	COG0659	secondary active sulfate transmembrane transporter activity
HVX74_13585	COG0012	GTP binding
HVX74_13590	COG3468	outer membrane autotransporter barrel domain protein
HVX74_13595	COG3284	Transcriptional regulator
HVX74_13600	COG2376	Dihydroxyacetone kinase
HVX74_13605	COG1461	Dihydroxyacetone kinase
HVX74_13610	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
HVX74_13610	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HVX74_13610	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HVX74_13630	COG1120	ATPase activity
HVX74_13635	COG0500	methyltransferase
HVX74_13640	COG0157	Belongs to the NadC ModD family
HVX74_13655	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
HVX74_13665	COG1619	proteins homologs of microcin C7 resistance protein MccF
HVX74_13675	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HVX74_13685	COG2719	SpoVR family
HVX74_13700	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
HVX74_13705	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HVX74_13710	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HVX74_13725	COG0179	Fumarylacetoacetate (FAA) hydrolase
HVX74_13750	COG2894	cell division
HVX74_13810	COG2200	EAL domain
HVX74_13835	COG2200	EAL domain
HVX74_13840	COG0789	Transcriptional regulator
HVX74_13845	COG5562	phage envelope protein
HVX74_13860	COG0538	isocitrate dehydrogenase activity
HVX74_13865	COG1187	pseudouridine synthase activity
HVX74_13885	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HVX74_13895	COG2205	protein histidine kinase activity
HVX74_13900	COG2850	peptidyl-arginine hydroxylation
HVX74_13910	COG3842	ATPase activity
HVX74_13920	COG1177	transmembrane transport
HVX74_13925	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HVX74_13935	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
HVX74_13940	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HVX74_13950	COG4591	ABC-type transport system involved in lipoprotein release permease component
HVX74_13960	COG4591	ABC-type transport system involved in lipoprotein release permease component
HVX74_13965	COG4763	Acyl-transferase
HVX74_13970	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HVX74_13975	COG1376	ErfK ybiS ycfS ynhG family protein
HVX74_13975	COG1388	LysM domain
HVX74_13985	COG1309	transcriptional regulator
HVX74_13990	COG3134	Outer membrane lipoprotein
HVX74_13995	COG1252	NADH dehydrogenase
HVX74_14015	COG3417	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)
HVX74_14020	COG5633	Lipoprotein
HVX74_14025	COG0537	adenosine 5'-monophosphoramidase activity
HVX74_14030	COG4773	Receptor
HVX74_14035	COG1263	PTS System
HVX74_14035	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HVX74_14040	COG0084	hydrolase, TatD family'
HVX74_14045	COG0470	DNA polymerase III
HVX74_14055	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HVX74_14060	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HVX74_14065	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HVX74_14075	COG1028	Short-chain dehydrogenase reductase Sdr
HVX74_14080	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HVX74_14100	COG1399	metal-binding, possibly nucleic acid-binding protein
HVX74_14105	COG0424	maF-like protein
HVX74_14110	COG0564	pseudouridine synthase activity
HVX74_14115	COG1530	ribonuclease E activity
HVX74_14120	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HVX74_14125	COG1256	bacterial-type flagellum assembly
HVX74_14130	COG1705	Flagellar rod assembly protein muramidase FlgJ
HVX74_14130	COG3951	Flagellar rod assembly protein muramidase FlgJ
HVX74_14145	COG4786	Flagellar basal body rod
HVX74_14150	COG4787	bacterial-type flagellum-dependent cell motility
HVX74_14155	COG1749	Flagellar hook protein flgE
HVX74_14160	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
HVX74_14165	COG1558	bacterial-type flagellum-dependent cell motility
HVX74_14170	COG1815	bacterial-type flagellum-dependent cell motility
HVX74_14175	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
HVX74_14180	COG2747	anti-sigma28 factor FlgM
HVX74_14185	COG3418	PFAM FlgN family protein
HVX74_14190	COG0728	peptidoglycan biosynthetic process
HVX74_14195	COG0673	inositol 2-dehydrogenase activity
HVX74_14205	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HVX74_14215	COG2999	glutathione oxidoreductase activity
HVX74_14250	COG3038	cytochrome b561
HVX74_14255	COG2353	YceI-like domain
HVX74_14265	COG1560	Kdo2-lipid A biosynthetic process
HVX74_14280	COG5645	(Lipo)protein
HVX74_14285	COG2943	transferase activity, transferring hexosyl groups
HVX74_14300	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HVX74_14305	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
HVX74_14330	COG2197	response regulator
HVX74_14345	COG1462	curli production assembly transport component CsgG
HVX74_14355	COG3381	protein complex oligomerization
HVX74_14420	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HVX74_14425	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HVX74_14435	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HVX74_14445	COG0736	holo-[acyl-carrier-protein] synthase activity
HVX74_14450	COG2831	hemolysin activation secretion protein
HVX74_14455	COG3210	domain, Protein
HVX74_14465	COG3539	Fimbrial protein
HVX74_14475	COG3188	usher protein
HVX74_14485	COG3121	Chaperone
HVX74_14490	COG1028	Short-chain dehydrogenase reductase Sdr
HVX74_14495	COG3710	Transcriptional regulator
HVX74_14505	COG2200	EAL domain
HVX74_14520	COG3658	cytochrome
HVX74_14525	COG1702	phosphate starvation-inducible protein PhoH
HVX74_14535	COG2822	iron ion transport
HVX74_14550	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HVX74_14555	COG0506	proline dehydrogenase activity
HVX74_14555	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HVX74_14555	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HVX74_14560	COG1309	transcriptional regulator
HVX74_14595	COG2233	PERMEase
HVX74_14600	COG3729	General stress protein
HVX74_14635	COG0243	molybdopterin cofactor binding
HVX74_14640	COG3005	denitrification pathway
HVX74_14645	COG0745	RESPONSE REGULATOR receiver
HVX74_14650	COG1879	ABC-type sugar transport system periplasmic component
HVX74_14655	COG2198	Histidine kinase
HVX74_14655	COG0784	Response regulator, receiver
HVX74_14655	COG2205	protein histidine kinase activity
HVX74_14660	COG0348	domain, Protein
HVX74_14680	COG1278	Cold shock
HVX74_14685	COG1278	Cold shock
HVX74_14705	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HVX74_14710	COG1596	polysaccharide export
HVX74_14715	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HVX74_14720	COG0489	protein tyrosine kinase activity
HVX74_14720	COG3206	protein involved in exopolysaccharide biosynthesis
HVX74_14735	COG1294	oxidase, subunit
HVX74_14740	COG1271	oxidase subunit
HVX74_14745	COG1773	rubredoxin
HVX74_14750	COG1999	signal sequence binding
HVX74_14755	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
HVX74_14760	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
HVX74_14765	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
HVX74_14770	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
HVX74_14780	COG0670	Belongs to the BI1 family
HVX74_14785	COG2920	part of a sulfur-relay system
HVX74_14790	COG1254	Belongs to the acylphosphatase family
HVX74_14805	COG1832	CoA-binding protein
HVX74_14820	COG0210	DNA helicase
HVX74_14825	COG3304	Inner membrane component domain
HVX74_14830	COG1289	transmembrane transporter activity
HVX74_14835	COG3070	regulator of competence-specific genes
HVX74_14855	COG1067	ATP-dependent peptidase activity
HVX74_14865	COG3130	regulation of translation
HVX74_14870	COG3009	Protein conserved in bacteria
HVX74_14875	COG3008	intermembrane lipid transfer
HVX74_14875	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HVX74_14880	COG2995	paraquat-inducible protein a
HVX74_14885	COG0488	(ABC) transporter
HVX74_14895	COG0633	Ferredoxin
HVX74_14895	COG3217	Mosc domain protein beta barrel domain protein
HVX74_14910	COG0431	NADPH-dependent FMN reductase
HVX74_14915	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HVX74_14925	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HVX74_14935	COG0308	aminopeptidase N
HVX74_14950	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HVX74_14955	COG1448	Aminotransferase
HVX74_14960	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HVX74_14965	COG3108	Peptidase M15
HVX74_14970	COG2989	Protein conserved in bacteria
HVX74_14980	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
HVX74_14990	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HVX74_14995	COG1434	Gram-negative-bacterium-type cell wall biogenesis
HVX74_15000	COG3173	Aminoglycoside phosphotransferase
HVX74_15015	COG3214	Protein conserved in bacteria
HVX74_15025	COG1132	(ABC) transporter
HVX74_15030	COG2333	competence protein COMEC
HVX74_15030	COG0658	competence protein
HVX74_15040	COG0539	negative regulation of cytoplasmic translation
HVX74_15050	COG0501	Belongs to the peptidase M48B family
HVX74_15065	COG2323	membrane
HVX74_15070	COG1944	ATP diphosphatase activity
HVX74_15075	COG2116	formate transmembrane transporter activity
HVX74_15080	COG1882	Formate acetyltransferase
HVX74_15085	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HVX74_15090	COG3118	belongs to the thioredoxin family
HVX74_15090	COG0457	Tetratricopeptide repeat
HVX74_15095	COG1215	transferase activity, transferring glycosyl groups
HVX74_15105	COG2199	diguanylate cyclase activity
HVX74_15110	COG2200	EAL domain
HVX74_15115	COG0531	amino acid
HVX74_15125	COG1335	isochorismatase
HVX74_15130	COG3302	dmso reductase anchor subunit
HVX74_15135	COG0437	4 iron, 4 sulfur cluster binding
HVX74_15140	COG0243	molybdopterin cofactor binding
HVX74_15150	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HVX74_15160	COG1178	ABC-type Fe3 transport system permease component
HVX74_15160	COG1674	ftsk spoiiie
HVX74_15165	COG1522	sequence-specific DNA binding
HVX74_15170	COG0492	ferredoxin-NADP+ reductase activity
HVX74_15175	COG4988	ABC transporter
HVX74_15180	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
HVX74_15200	COG0542	response to heat
HVX74_15210	COG1278	Cold shock
HVX74_15220	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HVX74_15225	COG2990	Protein conserved in bacteria
HVX74_15230	COG3593	DNA synthesis involved in DNA repair
HVX74_15240	COG2431	L-lysine efflux transmembrane transporter activity
HVX74_15245	COG1151	hydroxylamine reductase activity
HVX74_15250	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HVX74_15255	COG0028	Belongs to the TPP enzyme family
HVX74_15260	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
HVX74_15265	COG0702	epimerase
HVX74_15270	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HVX74_15275	COG3023	N-Acetylmuramoyl-L-alanine amidase
HVX74_15290	COG1126	abc transporter atp-binding protein
HVX74_15295	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HVX74_15300	COG4215	(ABC) transporter
HVX74_15305	COG4160	amino acid transport
HVX74_15310	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HVX74_15340	COG1177	transmembrane transport
HVX74_15345	COG1176	ABC-type spermidine putrescine transport system, permease component I
HVX74_15350	COG3842	ATPase activity
HVX74_15355	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HVX74_15370	COG0778	Nitroreductase
HVX74_15380	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HVX74_15395	COG3226	Transcriptional regulator
HVX74_15400	COG0738	Major facilitator superfamily
HVX74_15405	COG0561	phosphatase activity
HVX74_15415	COG2814	Major facilitator Superfamily
HVX74_15420	COG0671	phosphoesterase, PA-phosphatase related
HVX74_15425	COG1349	DNA-binding transcription factor activity
HVX74_15430	COG1686	Belongs to the peptidase S11 family
HVX74_15435	COG0625	glutathione transferase activity
HVX74_15440	COG2133	pyrroloquinoline quinone binding
HVX74_15465	COG2199	diguanylate cyclase activity
HVX74_15470	COG2200	EAL domain
HVX74_15485	COG0747	negative chemotaxis
HVX74_15495	COG1446	asparaginase
HVX74_15500	COG0303	'Molybdopterin
HVX74_15505	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HVX74_15510	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HVX74_15515	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HVX74_15520	COG1882	Formate acetyltransferase
HVX74_15525	COG0561	phosphatase activity
HVX74_15530	COG0488	(ABC) transporter
HVX74_15535	COG1376	ErfK ybiS ycfS ynhG family protein
HVX74_15540	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HVX74_15545	COG1321	iron dependent repressor
HVX74_15555	COG2194	sulfuric ester hydrolase activity
HVX74_15560	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
HVX74_15570	COG5006	permease, DMT superfamily
HVX74_15580	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HVX74_15585	COG0765	amino acid transport
HVX74_15590	COG1126	abc transporter atp-binding protein
HVX74_15595	COG0668	transmembrane transport
HVX74_15610	COG4774	siderophore transport
HVX74_15620	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HVX74_15630	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
HVX74_15635	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HVX74_15640	COG1199	ATP-dependent helicase activity
HVX74_15650	COG0513	Belongs to the DEAD box helicase family
HVX74_15655	COG1309	transcriptional regulator
HVX74_15665	COG1131	(ABC) transporter
HVX74_15670	COG0842	Transport permease protein
HVX74_15675	COG0842	Transport permease protein
HVX74_15685	COG3568	Endonuclease Exonuclease Phosphatase
HVX74_15690	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HVX74_15695	COG0392	lysyltransferase activity
HVX74_15710	COG0670	Belongs to the BI1 family
HVX74_15715	COG0670	Belongs to the BI1 family
HVX74_15720	COG0314	molybdopterin synthase activity
HVX74_15725	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
HVX74_15735	COG0521	Mo-molybdopterin cofactor biosynthetic process
HVX74_15745	COG0391	Required for morphogenesis under gluconeogenic growth conditions
HVX74_15755	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HVX74_15760	COG2226	methyltransferase
HVX74_15775	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HVX74_15780	COG1881	PFAM PEBP family protein
HVX74_15975	COG0305	Participates in initiation and elongation during chromosome replication
HVX74_16115	COG0582	viral genome integration into host DNA
HVX74_16120	COG4677	pectinesterase activity
HVX74_16125	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HVX74_16130	COG0471	metal ion transport
HVX74_16135	COG2828	Protein conserved in bacteria
HVX74_16140	COG0583	DNA-binding transcription factor activity
HVX74_16150	COG0561	phosphatase activity
HVX74_16155	COG4148	Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system
HVX74_16160	COG4149	molybdate abc transporter
HVX74_16165	COG0725	ABC transporter, periplasmic molybdate-binding protein
HVX74_16175	COG2005	Transcriptional regulator
HVX74_16175	COG3585	molybdate ion transport
HVX74_16180	COG1119	ATPase activity
HVX74_16185	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HVX74_16190	COG1085	galactose-1-phosphate uridylyltransferase
HVX74_16200	COG2017	converts alpha-aldose to the beta-anomer
HVX74_16210	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HVX74_16220	COG1230	cation diffusion facilitator family transporter
HVX74_16225	COG3201	nicotinamide mononucleotide transporter
HVX74_16275	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
HVX74_16280	COG2885	chlorophyll binding
HVX74_16290	COG3064	Membrane
HVX74_16295	COG0848	biopolymer transport protein
HVX74_16300	COG0811	peptide transport
HVX74_16305	COG0824	Thioesterase
HVX74_16310	COG3790	cyd operon protein YbgE
HVX74_16315	COG4890	Cyd operon protein YbgT
HVX74_16320	COG1294	oxidase, subunit
HVX74_16325	COG1271	oxidase subunit
HVX74_16340	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HVX74_16350	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HVX74_16360	COG0508	dehydrogenase complex catalyzes the overall conversion of
HVX74_16365	COG0567	Dehydrogenase, E1 component
HVX74_16370	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HVX74_16375	COG1053	succinate dehydrogenase
HVX74_16380	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
HVX74_16385	COG2009	succinate dehydrogenase
HVX74_16395	COG0372	Belongs to the citrate synthase family
HVX74_16400	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HVX74_16410	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HVX74_16415	COG2721	sulfolactate sulfo-lyase activity
HVX74_16425	COG1028	Short-chain dehydrogenase reductase Sdr
HVX74_16430	COG1063	alcohol dehydrogenase
HVX74_16435	COG0473	3-isopropylmalate dehydrogenase activity
HVX74_16435	COG0684	Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2- oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions
HVX74_16440	COG2186	Transcriptional regulator
HVX74_16445	COG3180	Ammonia monooxygenase
HVX74_16460	COG1984	allophanate hydrolase subunit 2
HVX74_16465	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
HVX74_16470	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HVX74_16480	COG0415	Belongs to the DNA photolyase family
HVX74_16485	COG3272	Protein of unknown function (DUF1722)
HVX74_16505	COG3209	COG3209 Rhs family protein
HVX74_16540	COG2205	protein histidine kinase activity
HVX74_16545	COG0745	RESPONSE REGULATOR receiver
HVX74_16550	COG0033	Phosphoglucomutase
HVX74_16555	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
HVX74_16560	COG0596	Alpha beta hydrolase
HVX74_16570	COG0716	FMN binding
HVX74_16580	COG0735	belongs to the Fur family
HVX74_16600	COG1263	PTS System
HVX74_16600	COG2190	(PTS) system
HVX74_16600	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HVX74_16610	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HVX74_16615	COG1846	Transcriptional regulator
HVX74_16615	COG1940	carbohydrate kinase activity
HVX74_16620	COG0647	UMP catabolic process
HVX74_16625	COG0367	asparagine synthase
HVX74_16670	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HVX74_16680	COG1702	phosphate starvation-inducible protein PhoH
HVX74_16690	COG4535	Mg2 and Co2 transporter CorC
HVX74_16695	COG0815	Transfers the fatty acyl group on membrane lipoproteins
HVX74_16700	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HVX74_16705	COG0765	amino acid transport
HVX74_16710	COG0765	amino acid transport
HVX74_16715	COG1126	abc transporter atp-binding protein
HVX74_16725	COG0443	Heat shock 70 kDa protein
HVX74_16730	COG2214	Heat shock protein DnaJ domain protein
HVX74_16740	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
HVX74_16745	COG2214	Heat shock protein DnaJ domain protein
HVX74_16755	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
HVX74_16760	COG2888	peptidyl-tyrosine sulfation
HVX74_16775	COG1466	dna polymerase III delta subunit
HVX74_16785	COG0406	alpha-ribazole phosphatase activity
HVX74_16790	COG0799	negative regulation of ribosome biogenesis
HVX74_16800	COG0768	penicillin binding
HVX74_16805	COG0772	Belongs to the SEDS family
HVX74_16810	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HVX74_16815	COG1686	Belongs to the peptidase S11 family
HVX74_16840	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HVX74_16845	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HVX74_16865	COG3069	C4-dicarboxylate transmembrane transporter activity
HVX74_16870	COG4565	transcriptional regulatory protein
HVX74_16875	COG3290	protein histidine kinase activity
HVX74_16880	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
HVX74_16890	COG2301	Belongs to the HpcH HpaI aldolase family
HVX74_16895	COG3051	citrate lyase alpha subunit
HVX74_16910	COG0471	metal ion transport
HVX74_16915	COG3719	Belongs to the RNase T2 family
HVX74_16920	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HVX74_16925	COG1063	alcohol dehydrogenase
HVX74_16930	COG0589	response to stress
HVX74_16935	COG3634	alkyl hydroperoxide reductase activity
HVX74_16940	COG0450	alkyl hydroperoxide reductase
HVX74_16945	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HVX74_16950	COG0583	DNA-binding transcription factor activity
HVX74_16955	COG3969	phosphoadenosine phosphosulfate
HVX74_16960	COG1475	DNA binding
HVX74_16965	COG0436	Aminotransferase
HVX74_16970	COG0371	Dehydrogenase
HVX74_16975	COG2879	small protein
HVX74_16980	COG1966	Carbon starvation protein
HVX74_16985	COG2050	protein possibly involved in aromatic compounds catabolism
HVX74_16990	COG1028	Short-chain dehydrogenase reductase Sdr
HVX74_16995	COG3433	isochorismatase activity
HVX74_16995	COG1535	isochorismatase
HVX74_17000	COG1021	2,3-dihydroxybenzoate-AMP ligase
HVX74_17005	COG1169	isochorismate synthase
HVX74_17010	COG4592	Periplasmic binding protein
HVX74_17020	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HVX74_17025	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HVX74_17030	COG1120	ATPase activity
HVX74_17035	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
HVX74_17040	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HVX74_17040	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
HVX74_17045	COG3251	PFAM MbtH domain protein
HVX74_17050	COG2382	esterase
HVX74_17055	COG4771	TonB-dependent receptor
HVX74_17060	COG2977	Belongs to the P-Pant transferase superfamily
HVX74_17085	COG2315	Protein conserved in bacteria
HVX74_17090	COG0778	Nitroreductase
HVX74_17095	COG0668	transmembrane transport
HVX74_17100	COG1113	amino acid transport
HVX74_17105	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HVX74_17110	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HVX74_17115	COG5569	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HVX74_17120	COG1538	Outer membrane efflux protein
HVX74_17125	COG0745	RESPONSE REGULATOR receiver
HVX74_17130	COG5002	protein histidine kinase activity
HVX74_17135	COG1215	transferase activity, transferring glycosyl groups
HVX74_17140	COG4783	chaperone-mediated protein folding
HVX74_17150	COG4571	Outer membrane protease
HVX74_17155	COG0500	methyltransferase
HVX74_17180	COG2501	S4 domain
HVX74_17185	COG1988	membrane-bound metal-dependent
HVX74_17195	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HVX74_17205	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HVX74_17210	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HVX74_17215	COG0549	Belongs to the carbamate kinase family
HVX74_17225	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HVX74_17230	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HVX74_17235	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
HVX74_17240	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HVX74_17245	COG3257	ureidoglycine aminohydrolase activity
HVX74_17250	COG1929	Belongs to the glycerate kinase type-1 family
HVX74_17255	COG2233	PERMEase
HVX74_17265	COG1953	Uracil, thiamine, allantoin
HVX74_17270	COG2084	Dehydrogenase
HVX74_17275	COG3622	Belongs to the hyi family
HVX74_17280	COG3960	tartronate-semialdehyde synthase activity
HVX74_17285	COG1414	Transcriptional regulator
HVX74_17295	COG0583	DNA-binding transcription factor activity
HVX74_17305	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
HVX74_17310	COG4181	ATPase activity
HVX74_17315	COG2755	lipolytic protein G-D-S-L family
HVX74_17320	COG0300	oxidoreductase activity
HVX74_17325	COG3118	belongs to the thioredoxin family
HVX74_17330	COG0390	transport system, permease component
HVX74_17335	COG4619	ABC transporter
HVX74_17340	COG0330	HflC and HflK could
HVX74_17345	COG1585	Membrane protein implicated in regulation of membrane protease activity
HVX74_17365	COG0789	Transcriptional regulator
HVX74_17390	COG0531	amino acid
HVX74_17400	COG2217	Heavy metal translocating P-type atpase
HVX74_17405	COG3735	TraB family
HVX74_17410	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HVX74_17415	COG0737	Belongs to the 5'-nucleotidase family
HVX74_17420	COG2223	nitrite transmembrane transporter activity
HVX74_17425	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HVX74_17425	COG4651	solute:proton antiporter activity
HVX74_17430	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HVX74_17465	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HVX74_17475	COG2832	Protein of unknown function (DUF454)
HVX74_17480	COG3923	Primosomal replication protein n
HVX74_17490	COG1196	nuclear chromosome segregation
HVX74_17490	COG3264	Mechanosensitive ion channel
HVX74_17495	COG1309	transcriptional regulator
HVX74_17500	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HVX74_17505	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HVX74_17520	COG0110	maltose O-acetyltransferase activity
HVX74_17530	COG4943	cyclic-guanylate-specific phosphodiesterase activity
HVX74_17535	COG5507	3-demethylubiquinone-9 3-methyltransferase
HVX74_17545	COG3695	enzyme binding
HVX74_17550	COG3126	Type III secretion system lipoprotein chaperone (YscW)
HVX74_17555	COG1946	Acyl-CoA thioesterase
HVX74_17560	COG0004	ammonium transporteR
HVX74_17565	COG0347	Belongs to the P(II) protein family
HVX74_17570	COG1132	(ABC) transporter
HVX74_17575	COG1132	(ABC) transporter
HVX74_17580	COG1522	sequence-specific DNA binding
HVX74_17585	COG0561	phosphatase activity
HVX74_17590	COG4533	DNA binding
HVX74_17600	COG0824	Thioesterase
HVX74_17605	COG1555	photosystem II stabilization
HVX74_17610	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HVX74_17615	COG0776	regulation of translation
HVX74_17620	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HVX74_17640	COG0271	Belongs to the BolA IbaG family
HVX74_17645	COG3056	Lipoprotein
HVX74_17650	COG2223	nitrite transmembrane transporter activity
HVX74_17655	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HVX74_17660	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HVX74_17665	COG1845	cytochrome c oxidase, subunit III
HVX74_17670	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
HVX74_17680	COG2814	Major facilitator Superfamily
HVX74_17690	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HVX74_17695	COG0693	protein deglycase activity
HVX74_17710	COG0142	geranyltranstransferase activity
HVX74_17720	COG0667	Aldo Keto reductase
HVX74_17730	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HVX74_17735	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
HVX74_17750	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HVX74_17750	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HVX74_17760	COG4238	major outer membrane lipoprotein
HVX74_17765	COG3248	Nucleoside-binding outer membrane protein
HVX74_17770	COG1403	HNH endonuclease
HVX74_17775	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HVX74_17780	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HVX74_17785	COG1862	Preprotein translocase
HVX74_17805	COG0366	Alpha amylase catalytic
HVX74_17810	COG1113	amino acid transport
HVX74_17815	COG1114	Component of the transport system for branched-chain amino acids
HVX74_17820	COG5002	protein histidine kinase activity
HVX74_17825	COG0745	RESPONSE REGULATOR receiver
HVX74_17830	COG0420	3'-5' exonuclease activity
HVX74_17835	COG0419	ATPase involved in DNA repair
HVX74_17840	COG2814	Major facilitator Superfamily
HVX74_17845	COG1940	carbohydrate kinase activity
HVX74_17870	COG4126	flavin adenine dinucleotide binding
HVX74_17890	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HVX74_17895	COG3706	GGDEF domain
HVX74_17905	COG1785	Belongs to the alkaline phosphatase family
HVX74_17920	COG1181	Belongs to the D-alanine--D-alanine ligase family
HVX74_17940	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
HVX74_17945	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HVX74_17950	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HVX74_17955	COG3468	outer membrane autotransporter barrel domain protein
HVX74_17960	COG0113	porphobilinogen synthase activity
HVX74_17965	COG2175	clavaminate synthase activity
HVX74_17970	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HVX74_17980	COG4521	taurine ABC transporter
HVX74_17990	COG1215	transferase activity, transferring glycosyl groups
HVX74_18020	COG3122	Protein conserved in bacteria
HVX74_18025	COG2814	Major facilitator Superfamily
HVX74_18060	COG1414	Transcriptional regulator
HVX74_18065	COG1609	Transcriptional regulator
HVX74_18075	COG2223	nitrite transmembrane transporter activity
HVX74_18080	COG0110	maltose O-acetyltransferase activity
HVX74_18085	COG2807	transmembrane transport
HVX74_18095	COG0288	reversible hydration of carbon dioxide
HVX74_18100	COG0583	DNA-binding transcription factor activity
HVX74_18105	COG0402	S-adenosylhomocysteine deaminase activity
HVX74_18110	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HVX74_18115	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HVX74_18120	COG2079	MmgE PrpD family protein
HVX74_18125	COG0372	Belongs to the citrate synthase family
HVX74_18130	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
HVX74_18135	COG3829	transcription factor binding
HVX74_18145	COG1280	lysine exporter protein (LysE YggA)
HVX74_18160	COG1064	alcohol dehydrogenase
HVX74_18170	COG1172	Belongs to the binding-protein-dependent transport system permease family
HVX74_18175	COG1129	ABC transporter
HVX74_18180	COG1879	ABC-type sugar transport system periplasmic component
HVX74_18190	COG0402	S-adenosylhomocysteine deaminase activity
HVX74_18195	COG0549	Belongs to the carbamate kinase family
HVX74_18200	COG1304	FMN binding
HVX74_18205	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HVX74_18215	COG0666	response to abiotic stimulus
HVX74_18225	COG0583	DNA-binding transcription factor activity
HVX74_18230	COG2771	luxR family
HVX74_18230	COG2200	EAL domain
HVX74_18240	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HVX74_18260	COG0582	viral genome integration into host DNA
HVX74_18265	COG2200	EAL domain
HVX74_18265	COG2771	luxR family
HVX74_18280	COG3468	outer membrane autotransporter barrel domain protein
HVX74_18290	COG1556	Lactate utilization protein
HVX74_18295	COG1139	Iron-sulfur cluster binding protein
HVX74_18300	COG0247	lactate metabolic process
HVX74_18305	COG2207	Transcriptional regulator
HVX74_18310	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HVX74_18320	COG3059	membrane
HVX74_18325	COG0656	L-ascorbic acid biosynthetic process
HVX74_18330	COG3708	Transcriptional regulator
HVX74_18330	COG2207	Transcriptional regulator
HVX74_18335	COG1388	LysM domain
HVX74_18340	COG0656	L-ascorbic acid biosynthetic process
HVX74_18405	COG0727	PFAM Uncharacterised protein family (UPF0153)
HVX74_18410	COG3477	response to acidic pH
HVX74_18415	COG2080	2 iron, 2 sulfur cluster binding
HVX74_18420	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
HVX74_18425	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HVX74_18430	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
HVX74_18445	COG0583	DNA-binding transcription factor activity
HVX74_18455	COG4221	oxidoreductase activity
HVX74_18460	COG0583	DNA-binding transcription factor activity
HVX74_18480	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HVX74_18495	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
HVX74_18505	COG3778	Protein conserved in bacteria
HVX74_18510	COG3299	homolog of phage Mu protein gp47
HVX74_18530	COG4228	DNA circulation
HVX74_18550	COG4386	tail sheath protein
HVX74_18595	COG4695	Portal protein
HVX74_18605	COG1802	Transcriptional regulator
HVX74_18605	COG4626	Terminase
HVX74_18690	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HVX74_18700	COG2076	Multidrug Resistance protein
HVX74_18785	COG0582	viral genome integration into host DNA
HVX74_18805	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HVX74_18825	COG2195	Cleaves the N-terminal amino acid of tripeptides
HVX74_18830	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
HVX74_18835	COG1690	Belongs to the RtcB family
HVX74_18840	COG0454	-acetyltransferase
HVX74_18860	COG1943	Transposase
HVX74_18865	COG0791	NLP P60 protein
HVX74_18870	COG3034	peptidoglycan biosynthetic process
HVX74_18875	COG0121	glutamine amidotransferase
HVX74_18885	COG1960	acyl-CoA dehydrogenase activity
HVX74_18895	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HVX74_18925	COG3209	COG3209 Rhs family protein
HVX74_18950	COG5433	transposase activity
HVX74_18975	COG2885	chlorophyll binding
HVX74_19050	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HVX74_19060	COG2226	methyltransferase
HVX74_19070	COG1388	LysM domain
HVX74_19070	COG0741	lytic transglycosylase activity
HVX74_19075	COG2226	methyltransferase
HVX74_19085	COG0583	DNA-binding transcription factor activity
HVX74_19090	COG0656	L-ascorbic acid biosynthetic process
HVX74_19125	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HVX74_19130	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HVX74_19135	COG2011	ABC-type metal ion transport system permease component
HVX74_19140	COG1464	Belongs to the NlpA lipoprotein family
HVX74_19150	COG1720	tRNA m6t6A37 methyltransferase activity
HVX74_19160	COG0791	NLP P60 protein
HVX74_19165	COG3015	lipoprotein NlpE involved in copper resistance
HVX74_19170	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
HVX74_19175	COG4681	YaeQ
HVX74_19185	COG4568	rho-dependent transcription termination
HVX74_19190	COG0037	tRNA processing
HVX74_19195	COG0346	lactoylglutathione lyase activity
HVX74_19210	COG0587	DNA-directed DNA polymerase activity
HVX74_19235	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HVX74_19240	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
HVX74_19250	COG0750	zinc metalloprotease
HVX74_19255	COG0575	Belongs to the CDS family
HVX74_19260	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HVX74_19265	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HVX74_19290	COG0024	Methionine aminopeptidase
HVX74_19310	COG3835	regulator
HVX74_19315	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HVX74_19330	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HVX74_19335	COG2860	membrane
HVX74_19360	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HVX74_19365	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HVX74_19370	COG1120	ATPase activity
HVX74_19375	COG4774	siderophore transport
HVX74_19380	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HVX74_19385	COG1643	Atp-dependent helicase
HVX74_19390	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
HVX74_19400	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HVX74_19410	COG0617	tRNA 3'-terminal CCA addition
HVX74_19415	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HVX74_19425	COG3121	Chaperone
HVX74_19430	COG3188	usher protein
HVX74_19435	COG3539	Fimbrial protein
HVX74_19440	COG3539	Fimbrial protein
HVX74_19445	COG3539	Fimbrial protein
HVX74_19460	COG0414	Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate
HVX74_19465	COG5464	transposase or invertase
HVX74_19475	COG0726	polysaccharide deacetylase
HVX74_19480	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HVX74_19485	COG0842	Transport permease protein
HVX74_19490	COG1131	(ABC) transporter
HVX74_19495	COG0288	reversible hydration of carbon dioxide
HVX74_19500	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
HVX74_19505	COG4993	Dehydrogenase
HVX74_19510	COG2132	Multicopper oxidase
HVX74_19535	COG1049	propionate catabolic process, 2-methylcitrate cycle
HVX74_19540	COG3064	Membrane
HVX74_19545	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HVX74_19550	COG0508	dehydrogenase complex catalyzes the overall conversion of
HVX74_19555	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
HVX74_19560	COG2186	Transcriptional regulator
HVX74_19570	COG3725	Membrane protein required for beta-lactamase induction
HVX74_19575	COG3023	N-Acetylmuramoyl-L-alanine amidase
HVX74_19580	COG0157	Belongs to the NadC ModD family
HVX74_19585	COG4969	Belongs to the N-Me-Phe pilin family
HVX74_19590	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HVX74_19595	COG1459	type II secretion system
HVX74_19610	COG0237	dephospho-CoA kinase activity
HVX74_19625	COG0494	nUDIX hydrolase
HVX74_19645	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HVX74_19650	COG0849	cell division
HVX74_19655	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
HVX74_19660	COG1181	Belongs to the D-alanine--D-alanine ligase family
HVX74_19675	COG0772	Belongs to the SEDS family
HVX74_19690	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HVX74_19695	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HVX74_19700	COG0768	penicillin binding
HVX74_19705	COG3116	cell division
HVX74_19720	COG1609	Transcriptional regulator
HVX74_19730	COG0440	acetolactate synthase activity
HVX74_19735	COG0028	Belongs to the TPP enzyme family
HVX74_19745	COG0583	DNA-binding transcription factor activity
HVX74_19785	COG4143	(ABC) transporter
HVX74_19790	COG1178	ABC-type Fe3 transport system permease component
HVX74_19800	COG0586	Pfam SNARE associated Golgi protein
HVX74_19805	COG4977	sequence-specific DNA binding
HVX74_19820	COG0235	Class ii aldolase
HVX74_19825	COG0417	DNA replication proofreading
HVX74_19835	COG0564	pseudouridine synthase activity
HVX74_19840	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
HVX74_19845	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
HVX74_19850	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HVX74_19885	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HVX74_19900	COG2271	Major facilitator Superfamily
HVX74_19905	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
HVX74_19910	COG0644	oxidoreductase
HVX74_19960	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HVX74_19965	COG0505	Belongs to the CarA family
HVX74_19985	COG1047	Peptidyl-prolyl cis-trans
HVX74_20000	COG0196	riboflavin kinase activity
HVX74_20015	COG0583	DNA-binding transcription factor activity
HVX74_20030	COG3119	arylsulfatase activity
HVX74_20060	COG4735	regulation of single-species biofilm formation
HVX74_20065	COG1584	GPR1 FUN34 yaaH family protein
HVX74_20070	COG0521	Mo-molybdopterin cofactor biosynthetic process
HVX74_20080	COG1115	amino acid carrier protein
HVX74_20095	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HVX74_20105	COG0527	aspartate kinase activity
HVX74_20105	COG0460	homoserine dehydrogenase
HVX74_20115	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
HVX74_20125	COG0745	RESPONSE REGULATOR receiver
HVX74_20130	COG4452	Inner membrane protein CreD
HVX74_20135	COG2205	protein histidine kinase activity
HVX74_20140	COG0745	RESPONSE REGULATOR receiver
HVX74_20145	COG3045	CreA protein
HVX74_20150	COG2207	Transcriptional regulator
HVX74_20150	COG3708	Transcriptional regulator
HVX74_20170	COG0741	lytic transglycosylase activity
HVX74_20175	COG0488	(ABC) transporter
HVX74_20180	COG0583	DNA-binding transcription factor activity
HVX74_20190	COG1028	Short-chain dehydrogenase reductase Sdr
HVX74_20205	COG1902	pentaerythritol trinitrate reductase activity
HVX74_20220	COG1056	cytidyltransferase-related domain
HVX74_20220	COG3172	ATPase kinase involved in NAD metabolism
HVX74_20225	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HVX74_20230	COG0560	Phosphoserine phosphatase
HVX74_20235	COG3726	membrane protein affecting hemolysin expression
HVX74_20270	COG1328	CTP reductase activity
HVX74_20275	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HVX74_20280	COG0084	hydrolase, TatD family'
HVX74_20285	COG4667	esterase of the alpha-beta hydrolase superfamily
HVX74_20295	COG2823	Periplasmic or secreted lipoprotein
HVX74_20305	COG1011	Hydrolase
HVX74_20310	COG0456	acetyltransferase
HVX74_20315	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
HVX74_20345	COG4114	ferric iron reductase
HVX74_20350	COG2197	response regulator
HVX74_20355	COG2197	response regulator
HVX74_20360	COG2966	Psort location CytoplasmicMembrane, score
HVX74_20375	COG1484	DNA-dependent DNA replication
HVX74_20390	COG1063	alcohol dehydrogenase
HVX74_20395	COG1802	Transcriptional regulator
HVX74_20400	COG2271	Major facilitator Superfamily
HVX74_20405	COG0840	transmembrane signaling receptor activity
HVX74_20410	COG1966	Carbon starvation protein
HVX74_20415	COG2879	small protein
HVX74_20420	COG0523	cobalamin synthesis protein
HVX74_20425	COG1715	Restriction endonuclease
HVX74_20430	COG4096	Type I site-specific restriction-modification system, R (Restriction) subunit and related
HVX74_20435	COG0286	site-specific DNA-methyltransferase (adenine-specific) activity
HVX74_20450	COG1401	restriction endodeoxyribonuclease activity
HVX74_20455	COG4268	DNA restriction-modification system
HVX74_20465	COG1196	nuclear chromosome segregation
HVX74_20470	COG5457	Domain of unknown function (DUF1127)
HVX74_20475	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HVX74_20485	COG2814	Major facilitator Superfamily
HVX74_20490	COG2733	membrane
HVX74_20495	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
HVX74_20500	COG1924	4 iron, 4 sulfur cluster binding
HVX74_20515	COG3204	pilus organization
HVX74_20520	COG0477	Major facilitator Superfamily
HVX74_20535	COG3366	ferrous iron transmembrane transporter activity
HVX74_20540	COG0700	Nucleoside recognition
HVX74_20545	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HVX74_20550	COG0583	DNA-binding transcription factor activity
HVX74_20565	COG2186	Transcriptional regulator
HVX74_20570	COG0246	Mannitol dehydrogenase
HVX74_20580	COG2610	gluconate transmembrane transporter activity
HVX74_20585	COG3539	Fimbrial protein
HVX74_20590	COG3539	Fimbrial protein
HVX74_20595	COG3539	Fimbrial protein
HVX74_20600	COG3188	usher protein
HVX74_20605	COG3121	Chaperone
HVX74_20610	COG3539	Fimbrial protein
HVX74_20615	COG3539	Fimbrial protein
HVX74_20620	COG4974	Belongs to the 'phage' integrase family
HVX74_20625	COG0582	viral genome integration into host DNA
HVX74_20630	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
HVX74_20670	COG1064	alcohol dehydrogenase
HVX74_20675	COG0433	COG0433 Predicted ATPase
HVX74_20680	COG0795	lipopolysaccharide-transporting ATPase activity
HVX74_20685	COG0795	lipopolysaccharide-transporting ATPase activity
HVX74_20695	COG2927	DNA polymerase III (CHI subunit)
HVX74_20700	COG0525	valine-tRNA ligase activity
HVX74_20710	COG0456	acetyltransferase
HVX74_20715	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
HVX74_20730	COG2731	YhcH YjgK YiaL family protein
HVX74_20735	COG1309	transcriptional regulator
HVX74_20740	COG1028	Short-chain dehydrogenase reductase Sdr
HVX74_20745	COG0251	oxidation-reduction process
HVX74_20765	COG0251	oxidation-reduction process
HVX74_20775	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HVX74_20785	COG1609	Transcriptional regulator
HVX74_20790	COG1263	PTS System
HVX74_20790	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HVX74_20795	COG0366	Alpha amylase catalytic
HVX74_20800	COG1328	CTP reductase activity
HVX74_20805	COG0602	queuosine metabolic process
HVX74_20810	COG3077	Addiction module antitoxin, RelB DinJ family
HVX74_20815	COG3783	Cytochrome b(562)
HVX74_20820	COG0312	modulator of DNA gyrase
HVX74_20830	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HVX74_20840	COG1172	Belongs to the binding-protein-dependent transport system permease family
HVX74_20845	COG1172	Belongs to the binding-protein-dependent transport system permease family
HVX74_20850	COG1129	ABC transporter
HVX74_20855	COG1879	ABC-type sugar transport system periplasmic component
HVX74_20860	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HVX74_20865	COG2337	Toxic component of a toxin-antitoxin (TA) module
HVX74_20870	COG2336	PFAM SpoVT AbrB
HVX74_20875	COG2105	PFAM AIG2 family protein
HVX74_20880	COG2911	Protein conserved in bacteria
HVX74_20885	COG0729	surface antigen
HVX74_20895	COG1253	flavin adenine dinucleotide binding
HVX74_20905	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
HVX74_20910	COG1218	3'(2'),5'-bisphosphate nucleotidase
HVX74_20915	COG0737	Belongs to the 5'-nucleotidase family
HVX74_20920	COG1733	regulation of RNA biosynthetic process
HVX74_20925	COG0702	epimerase
HVX74_20930	COG0697	spore germination
HVX74_20950	COG1113	amino acid transport
HVX74_20955	COG0545	Peptidyl-prolyl cis-trans isomerase
HVX74_20960	COG3061	Opacity-associated protein A
HVX74_20965	COG1309	transcriptional regulator
HVX74_20980	COG1024	Enoyl-CoA hydratase
HVX74_20985	COG4670	ketone body catabolic process
HVX74_20990	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HVX74_20995	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
HVX74_21005	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HVX74_21015	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HVX74_21055	COG3414	Phosphotransferase system galactitol-specific IIB component
HVX74_21060	COG3037	sugar-specific permease SgaT UlaA
HVX74_21075	COG1073	alpha beta
HVX74_21080	COG3650	response to hydrogen peroxide
HVX74_21090	COG1960	acyl-CoA dehydrogenase activity
HVX74_21095	COG0754	glutathionylspermidine amidase activity
HVX74_21100	COG5463	Belongs to the UPF0441 family
HVX74_21105	COG3766	membrane
HVX74_21115	COG1842	Phage shock protein A
HVX74_21120	COG3789	protein conserved in bacteria
HVX74_21125	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HVX74_21130	COG0557	exoribonuclease II activity
HVX74_21145	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
HVX74_21150	COG0330	HflC and HflK could
HVX74_21155	COG0330	HflC and HflK could
HVX74_21160	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HVX74_21180	COG0860	N-Acetylmuramoyl-L-alanine amidase
HVX74_21185	COG0802	atpase or kinase
HVX74_21190	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HVX74_21190	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HVX74_21195	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HVX74_21235	COG3264	Mechanosensitive ion channel
HVX74_21235	COG1511	domain protein
HVX74_21250	COG0531	amino acid
HVX74_21260	COG1053	succinate dehydrogenase
HVX74_21265	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HVX74_21280	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HVX74_21285	COG3040	lipid binding
HVX74_21290	COG2076	Multidrug Resistance protein
HVX74_21295	COG5510	response to toxic substance
HVX74_21300	COG5510	response to toxic substance
HVX74_21310	COG1509	lysine 2,3-aminomutase activity
HVX74_21335	COG0531	amino acid
HVX74_21340	COG3030	protein affecting phage T7 exclusion by the F plasmid
HVX74_21345	COG1027	Aspartate ammonia-lyase
HVX74_21350	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HVX74_21360	COG4232	protein-disulfide reductase activity
HVX74_21365	COG1309	transcriptional regulator
HVX74_21375	COG3710	Transcriptional regulator
HVX74_21380	COG0531	amino acid
HVX74_21385	COG1982	Orn Lys Arg decarboxylase major
HVX74_21390	COG3104	oligopeptide transport
HVX74_21395	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HVX74_21410	COG2388	GCN5-related N-acetyl-transferase
HVX74_21415	COG3592	Divergent 4Fe-4S mono-cluster
HVX74_21420	COG3290	protein histidine kinase activity
HVX74_21425	COG4565	transcriptional regulatory protein
HVX74_21430	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HVX74_21435	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HVX74_21435	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
HVX74_21440	COG3647	Membrane
HVX74_21445	COG2211	Major facilitator Superfamily
HVX74_21450	COG1486	melibiose metabolic process
HVX74_21455	COG2169	Transcriptional regulator
HVX74_21460	COG1982	Orn Lys Arg decarboxylase major
HVX74_21465	COG2207	Transcriptional regulator
HVX74_21470	COG0531	amino acid
HVX74_21475	COG2194	sulfuric ester hydrolase activity
HVX74_21480	COG0745	RESPONSE REGULATOR receiver
HVX74_21485	COG0642	Histidine kinase
HVX74_21495	COG0477	Major facilitator Superfamily
HVX74_21505	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
HVX74_21510	COG2824	Alkylphosphonate utilization operon protein PhnA
HVX74_21515	COG2764	glyoxalase bleomycin resistance protein dioxygenase
HVX74_21525	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
HVX74_21530	COG3639	organic phosphonate transmembrane transporter activity
HVX74_21535	COG2188	Transcriptional regulator
HVX74_21540	COG3624	Phosphonate C-P lyase system protein PhnG
HVX74_21545	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
HVX74_21550	COG3626	phosphonate metabolism
HVX74_21555	COG3627	carbon phosphorus lyase activity
HVX74_21560	COG4107	phosphonate C-P lyase system protein PhnK
HVX74_21565	COG4778	phosphonate C-P lyase system protein PhnL
HVX74_21570	COG3454	Phosphonate metabolism
HVX74_21580	COG0456	acetyltransferase
HVX74_21585	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
HVX74_21595	COG2015	COG2015, Alkyl sulfatase and related hydrolases
HVX74_21605	COG1566	PFAM secretion protein HlyD family protein
HVX74_21610	COG1289	transmembrane transporter activity
HVX74_21625	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
HVX74_21630	COG1301	dicarboxylic acid transport
HVX74_21635	COG4235	cytochrome complex assembly
HVX74_21640	COG3088	subunit of a heme lyase
HVX74_21645	COG1138	Cytochrome C-type biogenesis protein
HVX74_21650	COG3301	Polysulphide reductase, NrfD
HVX74_21655	COG0437	4 iron, 4 sulfur cluster binding
HVX74_21660	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
HVX74_21670	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HVX74_21675	COG3162	membrane
HVX74_21685	COG0025	NhaP-type Na H and K H
HVX74_21690	COG2252	PERMEase
HVX74_21695	COG0789	Transcriptional regulator
HVX74_21700	COG2207	Transcriptional regulator
HVX74_21705	COG4943	cyclic-guanylate-specific phosphodiesterase activity
HVX74_21715	COG0629	single-stranded DNA binding
HVX74_21720	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HVX74_21725	COG2315	Protein conserved in bacteria
HVX74_21730	COG0432	Pfam Uncharacterised protein family UPF0047
HVX74_21735	COG3700	Belongs to the class B bacterial acid phosphatase family
HVX74_21745	COG2204	response regulator
HVX74_21750	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
HVX74_21755	COG0471	metal ion transport
HVX74_21760	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HVX74_21765	COG0045	succinate-CoA ligase (ADP-forming) activity
HVX74_21770	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HVX74_21780	COG0567	Dehydrogenase, E1 component
HVX74_21785	COG1448	Aminotransferase
HVX74_21795	COG3201	nicotinamide mononucleotide transporter
HVX74_21800	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HVX74_21805	COG0305	Participates in initiation and elongation during chromosome replication
HVX74_21810	COG0604	alcohol dehydrogenase
HVX74_21820	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HVX74_21835	COG0582	viral genome integration into host DNA
HVX74_21855	COG3778	Protein conserved in bacteria
HVX74_21860	COG3299	homolog of phage Mu protein gp47
HVX74_21880	COG4228	DNA circulation
HVX74_21900	COG4386	tail sheath protein
HVX74_21945	COG4695	Portal protein
HVX74_21955	COG4626	Terminase
HVX74_21955	COG1802	Transcriptional regulator
HVX74_21990	COG0484	heat shock protein binding
HVX74_21995	COG1403	HNH endonuclease
HVX74_22005	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
HVX74_22015	COG4725	Belongs to the MT-A70-like family
HVX74_22020	COG1846	Transcriptional regulator
HVX74_22050	COG5532	Uncharacterized conserved protein (DUF2303)
HVX74_22055	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
HVX74_22100	COG0735	belongs to the Fur family
HVX74_22105	COG3237	CsbD-like
HVX74_22110	COG0534	Mate efflux family protein
HVX74_22120	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HVX74_22150	COG3842	ATPase activity
HVX74_22155	COG2182	Extracellular solute-binding protein
HVX74_22160	COG1175	transmembrane transport
HVX74_22165	COG3833	ABC-type maltose transport systems, permease component
HVX74_22170	COG2814	Major facilitator Superfamily
HVX74_22170	COG0477	Major facilitator Superfamily
HVX74_22185	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HVX74_22210	COG0527	aspartate kinase activity
HVX74_22220	COG1187	pseudouridine synthase activity
HVX74_22265	COG1283	sodium-dependent phosphate transmembrane transporter activity
HVX74_22270	COG1410	methionine synthase
HVX74_22270	COG0646	methionine synthase
HVX74_22275	COG1414	Transcriptional regulator
HVX74_22285	COG2224	Isocitrate lyase
HVX74_22290	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
HVX74_22300	COG0456	acetyltransferase
HVX74_22335	COG0151	Belongs to the GarS family
HVX74_22340	COG2204	response regulator
HVX74_22345	COG4191	Histidine kinase
HVX74_22350	COG3678	ATP-independent chaperone mediated protein folding
HVX74_22365	COG3068	Protein conserved in bacteria
HVX74_22385	COG3160	Binds RpoD and negatively regulates RpoD-mediated transcription activation by preventing the interaction between the primary sigma factor RpoD with the catalytic core of the RNA polymerase and with promoter DNA. May be involved in replacement of the RNA polymerase sigma subunit from RpoD to RpoS during the transition from exponential growth to the stationary phase
HVX74_22400	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HVX74_22405	COG2104	thiamine diphosphate biosynthetic process
HVX74_22415	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HVX74_22450	COG0250	Participates in transcription elongation, termination and antitermination
HVX74_22455	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HVX74_22490	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
HVX74_22490	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
HVX74_22525	COG4206	TonB-dependent receptor
HVX74_22540	COG1309	transcriptional regulator
HVX74_22545	COG0477	Major facilitator Superfamily
HVX74_22550	COG1473	amidohydrolase
HVX74_22560	COG0583	DNA-binding transcription factor activity
HVX74_22575	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HVX74_22590	COG2194	sulfuric ester hydrolase activity
HVX74_22595	COG2207	Transcriptional regulator
HVX74_22600	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HVX74_22605	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HVX74_22610	COG1882	Formate acetyltransferase
HVX74_22615	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HVX74_22620	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HVX74_22625	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HVX74_22625	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HVX74_22625	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HVX74_22630	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HVX74_22635	COG0371	Dehydrogenase
HVX74_22640	COG3738	Protein conserved in bacteria
HVX74_22645	COG0697	spore germination
HVX74_22655	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HVX74_22660	COG0737	Belongs to the 5'-nucleotidase family
HVX74_22670	COG0527	aspartate kinase activity
HVX74_22670	COG0460	homoserine dehydrogenase
HVX74_22675	COG0626	cystathionine gamma-synthase activity
HVX74_22685	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
HVX74_22695	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HVX74_22700	COG1609	Transcriptional regulator
HVX74_22705	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HVX74_22720	COG1575	Belongs to the MenA family. Type 1 subfamily
HVX74_22735	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HVX74_22745	COG1494	fructose-1,6-bisphosphatase
HVX74_22755	COG0589	response to stress
HVX74_22760	COG3691	Protein conserved in bacteria
HVX74_22765	COG3152	Membrane
HVX74_22780	COG0477	Major facilitator Superfamily
HVX74_22785	COG3829	transcription factor binding
HVX74_22790	COG4948	Mandelate Racemase Muconate Lactonizing
HVX74_22795	COG2223	nitrite transmembrane transporter activity
HVX74_22805	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
HVX74_22820	COG3678	ATP-independent chaperone mediated protein folding
HVX74_22825	COG0745	RESPONSE REGULATOR receiver
HVX74_22830	COG2205	protein histidine kinase activity
HVX74_22835	COG2258	MOSC domain
HVX74_22845	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HVX74_22890	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HVX74_22900	COG1363	Peptidase, m42
HVX74_22905	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HVX74_22905	COG3711	transcriptional antiterminator
HVX74_22920	COG0326	Molecular chaperone. Has ATPase activity
HVX74_22935	COG0437	4 iron, 4 sulfur cluster binding
HVX74_22940	COG2864	formate dehydrogenase
HVX74_22950	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HVX74_22955	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HVX74_22960	COG0456	acetyltransferase
HVX74_22975	COG1011	Hydrolase
HVX74_22985	COG0477	Major facilitator Superfamily
HVX74_22995	COG1063	alcohol dehydrogenase
HVX74_23000	COG3684	Belongs to the aldolase LacD family
HVX74_23005	COG2084	Dehydrogenase
HVX74_23010	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HVX74_23015	COG1349	DNA-binding transcription factor activity
HVX74_23025	COG0174	glutamine synthetase
HVX74_23030	COG3852	Histidine kinase
HVX74_23035	COG2204	response regulator
HVX74_23045	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HVX74_23060	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HVX74_23060	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HVX74_23065	COG0204	Acyl-transferase
HVX74_23070	COG5339	Protein conserved in bacteria
HVX74_23075	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HVX74_23080	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HVX74_23085	COG3084	Protein conserved in bacteria
HVX74_23090	COG0746	molybdenum cofactor guanylyltransferase activity
HVX74_23095	COG1763	Mo-molybdopterin cofactor biosynthetic process
HVX74_23125	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
HVX74_23130	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HVX74_23135	COG1739	Uncharacterized protein family UPF0029
HVX74_23155	COG0543	2 iron, 2 sulfur cluster binding
HVX74_23160	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HVX74_23165	COG0250	Participates in transcription elongation, termination and antitermination
HVX74_23175	COG0805	protein transport
HVX74_23180	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HVX74_23185	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HVX74_23195	COG3165	ubiquinone biosynthetic process from chorismate
HVX74_23205	COG1322	Protein conserved in bacteria
HVX74_23210	COG1414	Transcriptional regulator
HVX74_23215	COG3734	2-keto-3-deoxy-galactonokinase
HVX74_23220	COG0800	Aldolase
HVX74_23240	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
HVX74_23245	COG0412	Dienelactone hydrolase
HVX74_23250	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HVX74_23255	COG0583	DNA-binding transcription factor activity
HVX74_23260	COG0697	spore germination
HVX74_23265	COG0561	phosphatase activity
HVX74_23270	COG2267	carboxylic ester hydrolase activity
HVX74_23275	COG1280	lysine exporter protein (LysE YggA)
HVX74_23280	COG1280	lysine exporter protein (LysE YggA)
HVX74_23285	COG0514	ATP-dependent DNA helicase (RecQ)
HVX74_23290	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
HVX74_23295	COG2050	protein possibly involved in aromatic compounds catabolism
HVX74_23300	COG2962	Rard protein
HVX74_23305	COG0598	Magnesium transport protein CorA
HVX74_23310	COG3698	Phosphodiester glycosidase
HVX74_23315	COG1912	Pfam S-adenosyl-l-methionine hydroxide adenosyltransferase
HVX74_23320	COG0210	DNA helicase
HVX74_23325	COG1011	Hydrolase
HVX74_23335	COG3159	Protein conserved in bacteria
HVX74_23345	COG5567	small periplasmic lipoprotein
HVX74_23365	COG3072	Adenylate cyclase
HVX74_23375	COG1587	Uroporphyrinogen-III synthase
HVX74_23380	COG2959	enzyme of heme biosynthesis
HVX74_23385	COG3071	HemY protein
HVX74_23395	COG3119	arylsulfatase activity
HVX74_23400	COG0641	radical SAM
HVX74_23425	COG1113	amino acid transport
HVX74_23445	COG2244	polysaccharide biosynthetic process
HVX74_23450	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HVX74_23455	COG0456	acetyltransferase
HVX74_23460	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
HVX74_23465	COG1088	dTDP-glucose 4,6-dehydratase activity
HVX74_23470	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
HVX74_23475	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HVX74_23480	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
HVX74_23485	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HVX74_23490	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
HVX74_23500	COG3118	belongs to the thioredoxin family
HVX74_23515	COG0210	DNA helicase
HVX74_23520	COG3692	DNA binding
HVX74_23525	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HVX74_23535	COG0583	DNA-binding transcription factor activity
HVX74_23540	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HVX74_23550	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HVX74_23555	COG3978	acetolactate synthase activity
HVX74_23575	COG0606	chelatase, subunit chli
HVX74_23580	COG3085	chromosome segregation
HVX74_23620	COG2186	Transcriptional regulator
HVX74_23625	COG0477	Major facilitator Superfamily
HVX74_23630	COG1609	Transcriptional regulator
HVX74_23635	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HVX74_23640	COG1879	ABC-type sugar transport system periplasmic component
HVX74_23645	COG1172	Belongs to the binding-protein-dependent transport system permease family
HVX74_23650	COG1129	ABC transporter
HVX74_23680	COG1522	sequence-specific DNA binding
HVX74_23685	COG0716	FMN binding
HVX74_23700	COG3312	ion transport
HVX74_23755	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HVX74_23760	COG0573	inorganic phosphate transmembrane transporter activity
HVX74_23765	COG0581	inorganic phosphate transmembrane transporter activity
HVX74_23770	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HVX74_23775	COG0704	Plays a role in the regulation of phosphate uptake
HVX74_23780	COG3196	Protein conserved in bacteria
HVX74_23785	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HVX74_23790	COG2252	PERMEase
HVX74_23795	COG0431	NADPH-dependent FMN reductase
HVX74_23800	COG2091	lysine biosynthetic process via aminoadipic acid
HVX74_23815	COG0814	amino acid
HVX74_23955	COG4372	Transposase
HVX74_23960	COG3436	PFAM IS66 Orf2 family protein
HVX74_24195	COG1475	DNA binding