locus-tag class description HVX99_00035 ENOG4105ED4 portal protein HVX99_00130 ENOG4108X9F tail fiber protein HVX99_00130 ENOG4108X9F tail fiber protein HVX99_00135 ENOG4105UZW Tail fiber assembly protein HVX99_00180 ENOG4105ZTC transcriptional activator, Ogr delta HVX99_00185 ENOG4105CFP Peptidase U32 HVX99_00195 ENOG4105X54 addiction module antidote protein HVX99_00200 ENOG4105KWI UPF0339 protein HVX99_00205 ENOG4105E3W Two component transcriptional regulator (Winged helix family HVX99_00210 ENOG4105EB3 Histidine kinase HVX99_00245 ENOG4108M24 von Willebrand factor, type A HVX99_00250 ENOG4105UM3 Inherit from NOG: serine threonine phosphoprotein phosphatase HVX99_00255 ENOG4105ZD5 Uncharacterized protein conserved in bacteria (DUF2314) HVX99_00275 ENOG4105R8A Heat shock protein HVX99_00280 ENOG4105D03 DNA-3-methyladenine glycosylase II HVX99_00285 ENOG4105BZU Histidine kinase HVX99_00290 ENOG4105DBI uridine monophosphokinase HVX99_00300 ENOG4108GAE asmA family HVX99_00305 ENOG4105EE5 Membrane protein terC HVX99_00315 ENOG4105DAY polysaccharide export protein HVX99_00320 ENOG4105KJF protein tyrosine phosphatase HVX99_00325 ENOG4105D75 Capsular exopolysaccharide family HVX99_00330 ENOG41090RK glycosyl transferase HVX99_00335 ENOG41068PY Colanic acid biosynthesis acetyltransferase wcaB HVX99_00340 ENOG4107RXY Glycosyl transferase HVX99_00345 ENOG4108NYJ Colanic acid HVX99_00350 ENOG4105ECJ Glycosyl Transferase HVX99_00355 ENOG4108Z90 colanic acid biosynthesis acetyltransferase wcaF HVX99_00360 ENOG4105C0K Gdp-mannose 4,6-dehydratase HVX99_00365 ENOG4105C30 Nad-dependent epimerase dehydratase HVX99_00370 ENOG4105FGF GDP-mannose mannosyl hydrolase HVX99_00375 ENOG4106CD9 glycosyl transferase group 1 HVX99_00380 ENOG4105CJT Mannose-1-phosphate guanylyltransferase HVX99_00385 ENOG4107QKV phosphomannomutase HVX99_00390 ENOG4105D3Q Sugar transferase HVX99_00395 ENOG4105PSV Polysaccharide Biosynthesis Protein HVX99_00400 ENOG4105C74 pyruvyl transferase HVX99_00405 ENOG4107T8Q Glycosyl transferase (Group 1 HVX99_00410 ENOG4105G1A colanic acid biosynthesis protein HVX99_00415 ENOG4105DMT epimerase dehydratase HVX99_00420 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase HVX99_00440 ENOG4105BZF Glycosyl transferase (Group 1 HVX99_00445 ENOG4105CJT Mannose-1-phosphate guanylyltransferase HVX99_00450 ENOG4107QKV phosphomannomutase HVX99_00465 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) HVX99_00475 ENOG4108KPN Confers a modal distribution of chain length on the O- antigen component of lipopolysaccharide (LPS). Gives rise to a reduced number of short chain molecules and increases in numbers of longer molecules, with a modal value of 13 (in strain O111 M92) and of 17 (in strain K12) HVX99_00495 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) HVX99_00500 ENOG4105ECC imidazole-glycerol-phosphate dehydratase HVX99_00525 ENOG4105VTW prevent-host-death family HVX99_00530 ENOG4105KRQ Addiction module toxin, Txe YoeB family HVX99_00535 ENOG4107SRH Nad-dependent epimerase dehydratase HVX99_00540 ENOG4105EQ1 Transcriptional regulator HVX99_00550 ENOG4105CUB amino acid HVX99_00555 ENOG4105CUC YeeE YedE family protein HVX99_00565 ENOG4105CJB Exodeoxyribonuclease I HVX99_00570 ENOG4105DZ1 carboxypeptidase HVX99_00580 ENOG4105DR8 Membrane HVX99_00590 ENOG4105KTW ethanolamine utilization protein HVX99_00595 ENOG4105M3W utilization protein HVX99_00605 ENOG4107QTR Required for nitrogen fixation. May be part of a membrane complex functioning as an intermediate in the electron transport to nitrogenase (By similarity) HVX99_00610 ENOG4105C0A alcohol dehydrogenase HVX99_00615 ENOG4108EKI Dehydrogenase HVX99_00625 ENOG4105WVM ethanolamine utilization protein EutN carboxysome structural protein Ccml HVX99_00635 ENOG4108VPX Involved in 1,2-propanediol (1,2-PD) degradation by catalyzing the conversion of propanoyl-CoA to propanoyl-phosphate (By similarity) HVX99_00640 ENOG4105KNY Microcompartments protein HVX99_00645 ENOG4105KNY Microcompartments protein HVX99_00655 ENOG41084PW diol glycerol dehydratase reactivating factor large subunit HVX99_00660 ENOG4108ZFT Dehydratase small subunit HVX99_00665 ENOG4105YCI dehydratase medium subunit HVX99_00670 ENOG4105DMB glycerol dehydratase HVX99_00675 ENOG4105EHR propanediol utilization protein pduB HVX99_00680 ENOG4105KNY Microcompartments protein HVX99_00685 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) HVX99_00690 ENOG4107XVH Transcriptional regulator HVX99_00695 ENOG4108P62 biosynthesis protein (CbiG) HVX99_00700 ENOG4108YZT Adenosylcobinamide kinase HVX99_00715 ENOG4108PXI ErfK YbiS YcfS YnhG HVX99_00725 ENOG4106P55 Transcriptional regulator HVX99_00730 ENOG4107R11 Transcriptional regulator HVX99_00740 ENOG4105UQX Mate efflux family protein HVX99_00750 ENOG4105CDY transcriptional regulatory protein HVX99_00755 ENOG4105FYV Amp nucleosidase HVX99_00760 ENOG4105CSH Transporter HVX99_00790 ENOG4108VKM cytochrome b561 HVX99_00795 ENOG4108MEK Metal-binding protein YodA HVX99_00800 ENOG4105DQ2 Is probably involved in the electron transfer between its heme and the molybdenum cofactor of the reductase catalytic subunit YedY (By similarity) HVX99_00805 ENOG4105CCD The exact function is not known. Can catalyze the reduction of a variety of substrates like dimethyl sulfoxide, trimethylamine N-oxide, phenylmethyl sulfoxide and L-methionine sulfoxide. Cannot reduce cyclic N-oxides. Shows no activity as sulfite oxidase (By similarity) HVX99_00810 ENOG4105VT2 5-hydroxyisourate hydrolase HVX99_00815 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HVX99_00820 ENOG4107ZY3 Histidine kinase HVX99_00830 ENOG4105ZIT Porin Gram-negative type HVX99_00835 ENOG4105Y0K Inner membrane protein YedR HVX99_00840 ENOG4105EST Metal Dependent Phosphohydrolase HVX99_00845 ENOG4105DVF Cytosine-specific methyltransferase HVX99_00850 ENOG41090BB DNA mismatch endonuclease (vsr) HVX99_00855 ENOG4105FDR Membrane HVX99_00860 ENOG4105CKW Inner membrane protein yedI HVX99_00865 ENOG4105VNZ cytoplasmic protein HVX99_00880 ENOG4105YX3 cellular response to acidity HVX99_00890 ENOG4107TKS colanic acid capsular biosynthesis activation protein A HVX99_00895 ENOG4105D19 Role in flagellar biosynthesis (By similarity) HVX99_00905 ENOG4105CN7 Flagellar biosynthetic protein FliP HVX99_00910 ENOG4105K0P flagellar biosynthesis protein HVX99_00915 ENOG4105DD5 Flagellar motor switch protein HVX99_00920 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) HVX99_00925 ENOG4107ZI8 flagellar basal body-associated protein flil HVX99_00930 ENOG4105WF4 Flagellar hook-length control protein HVX99_00935 ENOG4105GSA Flagellar export protein flij HVX99_00940 ENOG4108JIR Flagellum-specific ATP synthase HVX99_00945 ENOG41090PJ Flagellar assembly protein HVX99_00950 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) HVX99_00955 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) HVX99_00965 ENOG4108RAV Conserved protein HVX99_00975 ENOG41066VF YeeE YedE family protein HVX99_00980 ENOG4108W9D (LipO)protein HVX99_00985 ENOG4105E5K Alpha-amylase HVX99_00995 ENOG4105MQ3 flagellar protein FliS HVX99_01000 ENOG4105DTS flagellar hook-associated HVX99_01010 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HVX99_01015 ENOG4108M9K flagella biosynthesis protein FliZ HVX99_01020 ENOG4105EAB amino acid AbC transporter HVX99_01030 ENOG4105E5Q amino acid AbC transporter HVX99_01035 ENOG4105CDA abc transporter atp-binding protein HVX99_01040 ENOG4105VJY transcriptional regulator HVX99_01045 ENOG4105XVG cytoplasmic protein HVX99_01055 ENOG4105WH1 Two component transcriptional regulator luxr family HVX99_01085 ENOG4106RHG Yeca family HVX99_01090 ENOG4105E0U tyrosine-specific transport protein HVX99_01095 ENOG4105VVZ metal-binding protein HVX99_01100 ENOG41090A1 ferritin HVX99_01105 ENOG4105P23 (LipO)protein HVX99_01115 ENOG4105N4N Protein of unknown function (DUF2766) HVX99_01120 ENOG4108UEC Ferritin-like protein HVX99_01125 ENOG4105DMK Periplasmic binding protein LacI transcriptional regulator HVX99_01130 ENOG4105C2J ABC transporter HVX99_01135 ENOG4105CNN ABC, transporter HVX99_01140 ENOG4108K4C ec 3.1.3.12 HVX99_01150 ENOG4108VA4 Universal stress protein HVX99_01160 ENOG4106CIA Functions in complex with FlhD as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region HVX99_01165 ENOG4107RD7 Flagellar Motor Protein, MotA HVX99_01170 ENOG4105ER2 Ompa motb domain protein HVX99_01175 ENOG4105CBS Chea signal transduction histidine kinase HVX99_01180 ENOG4108V3W Chemotaxis protein, CheW HVX99_01185 ENOG4105C8Q Methyl-accepting chemotaxis HVX99_01190 ENOG4105C8Q Methyl-accepting chemotaxis HVX99_01195 ENOG4105BZU Histidine kinase HVX99_01200 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) HVX99_01205 ENOG4108VYJ response regulator receiver protein HVX99_01210 ENOG4108KCC Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P) (By similarity) HVX99_01215 ENOG4105D00 flagellar biosynthetic protein flhB HVX99_01220 ENOG4105D7B Flagellar biosynthesis protein flha HVX99_01225 ENOG4105W13 flagellar protein HVX99_01240 ENOG4106ZCM YecM protein HVX99_01250 ENOG4105CUW cytochrome C-TYPE protein HVX99_01255 ENOG4107QY8 reductase HVX99_01275 ENOG4105WJG Glutathione HVX99_01280 ENOG41081XQ Conserved Protein HVX99_01285 ENOG4105D3W isochorismatase HVX99_01295 ENOG4108TIT dATP pyrophosphohydrolase HVX99_01300 ENOG4105CDY transcriptional regulatory protein HVX99_01310 ENOG4107S01 Repressor protein MetJ HVX99_01330 ENOG4105FAV ABC, transporter HVX99_01340 ENOG4105NXV High-affinity zinc uptake system protein HVX99_01345 ENOG4105DR5 peptidase HVX99_01350 ENOG4105NWR lipid A biosynthesis (Kdo)2-(Lauroyl)-lipid IVA acyltransferase HVX99_01355 ENOG4105CA9 Pyruvate kinase HVX99_01360 ENOG4106KNT transcriptional regulator HVX99_01365 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase HVX99_01370 ENOG4105C01 Dihydroxy-acid dehydratase HVX99_01375 ENOG4108UHU Aldolase HVX99_01385 ENOG4105X2V dna damage-inducible protein HVX99_01395 ENOG4108Q2J Inner membrane protein YebE HVX99_01400 ENOG4105CUG Oligopeptidase b HVX99_01405 ENOG4105UMD exodeoxyribonuclease X HVX99_01410 ENOG4108YGA nitrilase cyanide hydratase and apolipoprotein n-acyltransferase HVX99_01415 ENOG4105MPK DNA polymerase III subunit theta HVX99_01420 ENOG4105FXM Copper resistance protein HVX99_01425 ENOG4108PNC copper resistance HVX99_01430 ENOG4105NKT exported protein HVX99_01435 ENOG4108R1E Serine threonine protein phosphatase 1 HVX99_01440 ENOG4105UVW uncharacterized protein yebW HVX99_01445 ENOG4105WT8 Protein of unknown function (DUF1480) HVX99_01455 ENOG4105DY2 Paraquat-inducible protein b HVX99_01460 ENOG4105H2K paraquat-inducible protein a HVX99_01465 ENOG4108ZGC gaf domain protein HVX99_01475 ENOG4105CN1 protease HVX99_01485 ENOG4105C0R drug resistance transporter emrb qaca subfamily HVX99_01490 ENOG4105J4Q Transcriptional regulator HVX99_01495 ENOG4105TIK HVX99_01505 ENOG4105Q3Y exported protein HVX99_01520 ENOG4105DHI Methyltransferase HVX99_01535 ENOG4105F3R pts system mannose fructose sorbose family iid HVX99_01540 ENOG4105ETZ PTS System HVX99_01545 ENOG4105DAS pts system HVX99_01550 ENOG4105EE5 Membrane protein terC HVX99_01555 ENOG4107XTP (EAL) domain protein HVX99_01560 ENOG4105EJQ L-serine dehydratase HVX99_01570 ENOG4105CRQ synthase (Component I) HVX99_01580 ENOG4105V2F Uncharacterized protein yoac HVX99_01585 ENOG4105M4H endoribonuclease L-psp HVX99_01590 ENOG4105DVT helicase HVX99_01595 ENOG41072GX Peptidase M22 Glycoprotease HVX99_01600 ENOG4105Y4Z Outer Membrane Lipoprotein HVX99_01605 ENOG4105CEY Amp-dependent synthetase and ligase HVX99_01610 ENOG4105ZIE Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity) HVX99_01615 ENOG4105E3J oxidoreductase HVX99_01620 ENOG4105DVW rieske (2Fe-2S) HVX99_01625 ENOG4105C94 Transporter HVX99_01630 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) HVX99_01635 ENOG4105EJC lysr family transcriptional regulator HVX99_01645 ENOG4108YS1 cytoplasmic protein HVX99_01650 ENOG4105YP6 Domain of unknown function (DUF1869) HVX99_01660 ENOG4105D7V transposase HVX99_01665 ENOG4105Y3U Transglycosylase-associated protein HVX99_01675 ENOG4106G4W HVX99_01680 ENOG410620I Diguanylate cyclase HVX99_01685 ENOG4105UCG Domain of unknown function (DUF333) HVX99_01690 ENOG4105K78 MarR family Transcriptional regulator HVX99_01695 ENOG4105DJ2 Major Facilitator Superfamily HVX99_01700 ENOG4105R1U AraC Family Transcriptional Regulator HVX99_01715 ENOG4108KXH Ybak prolyl-tRNA synthetase associated HVX99_01720 ENOG4108KHP Diguanylate cyclase HVX99_01725 ENOG4106KTS Inner membrane protein yeaI HVX99_01735 ENOG4105CYN Serine protein kinase HVX99_01740 ENOG4105GNX MltA-interacting MipA family protein HVX99_01745 ENOG4105CV8 reductase HVX99_01750 ENOG4105DSB aldose 1-epimerase HVX99_01755 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase HVX99_01765 ENOG4105VUT cytoplasmic protein HVX99_01770 ENOG4105CPQ Dehydrogenase HVX99_01775 ENOG4107TE1 transport protein HVX99_01780 ENOG4105CPQ Dehydrogenase HVX99_01785 ENOG4105D2N Aldolase HVX99_01790 ENOG4107UH8 sugar kinase HVX99_01795 ENOG4105CPC Aldo Keto reductase HVX99_01800 ENOG4105E98 transcriptional regulator DeoR family HVX99_01805 ENOG4108KUU Inner membrane metabolite transport protein ydjE HVX99_01810 ENOG4108RWI nicotinamidase HVX99_01815 ENOG4105HDK L-asparaginase HVX99_01820 ENOG4105D07 Signal peptide peptidase, SppA HVX99_01825 ENOG41069NU Nitroreductase HVX99_01835 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) HVX99_01840 ENOG41065FB inner membrane protein ynji HVX99_01845 ENOG4105D82 Glutamate dehydrogenase HVX99_01850 ENOG4105MTM Protein of unknown function (DUF1496) HVX99_01855 ENOG4105M6F mutator MutT protein HVX99_01860 ENOG4108T9J Cdp-alcohol phosphatidyltransferase HVX99_01865 ENOG4107RM6 sulfurtransferase HVX99_01870 ENOG4108VGW abc transporter atp-binding protein HVX99_01875 ENOG4105CXZ ABC transporter, permease HVX99_01880 ENOG4105VNH ABC transporter solute-binding protein HVX99_01885 ENOG4107ZN8 Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) HVX99_01890 ENOG4108N5C SNARE associated Golgi protein-related protein HVX99_01895 ENOG4108KCW iron-sulfur cluster binding HVX99_01900 ENOG4108RSN SNARE associated Golgi HVX99_01905 ENOG4105CGK Exodeoxyribonuclease III HVX99_01935 ENOG4108SPG Periplasmic Protein HVX99_01945 ENOG4105DKD Incises the DNA at the 3' side of a lesion during nucleotide excision repair. Incises the DNA farther away from the lesion than UvrC. Not able to incise the 5' site of a lesion. When a lesion remains because UvrC is not able to induce the 3' incision, Cho incises the DNA. Then UvrC makes the 5' incision. The combined action of Cho and UvrC broadens the substrate range of nucleotide excision repair (By similarity) HVX99_01955 ENOG4105KKI DNA-binding transcriptional activator OsmE HVX99_01960 ENOG4105VZJ PTS System HVX99_01965 ENOG4105CK1 PTS System HVX99_01970 ENOG4105VCP PTS System HVX99_01975 ENOG4105EZV Transcriptional regulator HVX99_01980 ENOG4105F8D glycoside hydrolase family 4 HVX99_01990 ENOG4105CH6 catalase HVX99_02010 ENOG4108ETY sodium dicarboxylate symporter HVX99_02015 ENOG4107K5X Membrane-bound metal-dependent hydrolase HVX99_02020 ENOG4107UW8 HAD-superfamily hydrolase subfamily IA variant 3 HVX99_02025 ENOG4107PN8 YfeABCD locus regulator HVX99_02035 ENOG4105P10 Uncharacterized protein ydiZ HVX99_02040 ENOG4105DE4 1-phosphofructokinase HVX99_02045 ENOG4108NE3 Salt-induced outer membrane protein HVX99_02065 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) HVX99_02070 ENOG41082NX 50s ribosomal protein l35 HVX99_02155 ENOG4105UZW Tail fiber assembly protein HVX99_02160 ENOG410685N tail fiber protein HVX99_02240 ENOG4105ED4 portal protein HVX99_02315 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HVX99_02335 ENOG4108V06 Glutathione peroxidase HVX99_02345 ENOG4108QBX (LipO)protein HVX99_02350 ENOG4108TC0 Diguanylate phosphodiesterase HVX99_02365 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) HVX99_02375 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) HVX99_02380 ENOG4105CEY Amp-dependent synthetase and ligase HVX99_02385 ENOG41090P5 ferredoxin-like protein HVX99_02390 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase HVX99_02395 ENOG4105C10 Electron transfer flavoprotein HVX99_02400 ENOG4105CV7 Electron transfer flavoprotein HVX99_02405 ENOG4105W4W Transcriptional regulator HVX99_02410 ENOG4105C1G acyl-Coa dehydrogenase HVX99_02415 ENOG4108IIG CoA transferase having broad substrate specificity for short-chain acyl-CoA thioesters with the activity decreasing when the length of the carboxylic acid chain exceeds four carbons (By similarity) HVX99_02430 ENOG4105EMV Major Facilitator HVX99_02435 ENOG4105EMV Major Facilitator HVX99_02440 ENOG4105SUA Ydil protein HVX99_02450 ENOG4105IPI Membrane HVX99_02455 ENOG4105CQB FAD linked oxidase domain protein HVX99_02460 ENOG4105KA0 thioesterase Superfamily protein HVX99_02465 ENOG410671Z uncharacterized protein ydiH HVX99_02470 ENOG4108Z4V iron-sulfur cluster assembly HVX99_02475 ENOG4105DIW FeS assembly protein SUFB HVX99_02480 ENOG4105C3K feS assembly ATPase SufC HVX99_02485 ENOG4105JRK feS assembly protein SufD HVX99_02500 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein HVX99_02505 ENOG4105KMX major outer membrane lipoprotein HVX99_02510 ENOG4105CA9 Pyruvate kinase HVX99_02515 ENOG4105RFR Protein of unknown function (DUF2767) HVX99_02520 ENOG4108PU5 4fe-4S ferredoxin, iron-sulfur binding domain protein HVX99_02525 ENOG4105WE2 aldehyde ferredoxin oxidoreductase HVX99_02530 ENOG4105JVW HVX99_02535 ENOG4108393 oxidoreductase Fe-S subunit HVX99_02540 ENOG4108NWD Cytochrome HVX99_02545 ENOG4108Y7C Conserved Protein HVX99_02550 ENOG4108KTU conserved protein with FAD NAD(P)-binding domain HVX99_02555 ENOG4105N0V mono-oxygenase ydhR HVX99_02580 ENOG4108R6K riboflavin synthase, subunit alpha HVX99_02585 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase HVX99_02590 ENOG4105CZQ inner membrane transport protein YdhC HVX99_02595 ENOG4105F52 Transcriptional regulator HVX99_02610 ENOG4105F27 Major Facilitator HVX99_02615 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) HVX99_02620 ENOG4105K4H Nlp p60 protein HVX99_02625 ENOG4105M2J Glutaredoxin HVX99_02630 ENOG4107QRT dEAD DEAH box helicase HVX99_02640 ENOG4108UYE Lactoylglutathione lyase HVX99_02645 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HVX99_02650 ENOG4108WUH Transcriptional regulator, TetR family HVX99_02655 ENOG4105XZD Fe-S protein HVX99_02660 ENOG4107RGM aldo keto reductase HVX99_02665 ENOG4108Z7T Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) HVX99_02670 ENOG4105DSW Fusaric acid resistance protein HVX99_02675 ENOG4105Y49 secretion protein, HlyD family HVX99_02690 ENOG4108XTF Outer Membrane Lipoprotein HVX99_02700 ENOG410642K Lysozyme inhibitor HVX99_02715 ENOG4107XGF functions in a salvage pathway. Uses pyridoxamine (By similarity) HVX99_02720 ENOG4108K3A Glutathione S-transferase HVX99_02725 ENOG4105DUX Transporter HVX99_02730 ENOG4105CSM endonuclease III HVX99_02740 ENOG4108UQQ Electron transport complex HVX99_02765 ENOG4105M9B inner membrane protein ydgK HVX99_02770 ENOG4105QZ5 OriC-binding nucleoid-associated protein HVX99_02775 ENOG4106C6R beta-lactam resistance protein HVX99_02780 ENOG4105D9R oxidoreductase HVX99_02790 ENOG4105C87 Aminotransferase class I and II HVX99_02795 ENOG4105CI1 PTS System HVX99_02800 ENOG4107P2S Transcriptional regulator HVX99_02805 ENOG4107ZQV short-chain dehydrogenase reductase HVX99_02810 ENOG4105XEA Tetr family transcriptional regulator HVX99_02815 ENOG4105CNT hydrolase family 2 HVX99_02820 ENOG4105CT4 transporter HVX99_02825 ENOG4108QNI outer membrane porin protein HVX99_02830 ENOG4106J39 exported protein HVX99_02835 ENOG4105EIP mannose-6-phosphate isomerase HVX99_02840 ENOG4107GFK fumarate HVX99_02845 ENOG4105C9Q fumarate hydratase class II HVX99_02855 ENOG4105JJR Histidine kinase HVX99_02860 ENOG4107EXC regulatoR HVX99_02865 ENOG4105RA2 Membrane HVX99_02875 ENOG4105D5Q Arginine ornithine antiporter HVX99_02880 ENOG4105C5D exported protein HVX99_02885 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) HVX99_02890 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) HVX99_02895 ENOG4105DSF transport protein HVX99_02910 ENOG4105CVW peptidase s1 and s6 chymotrypsin hap HVX99_02925 ENOG4105D94 Major Facilitator Superfamily HVX99_02930 ENOG4106NZI LysR family Transcriptional regulator HVX99_02935 ENOG4105DAG ROK family HVX99_02940 ENOG4105EWW Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) HVX99_02950 ENOG4108NEM leader-binding protein dmsD HVX99_02955 ENOG4107KGK dmso reductase anchor subunit HVX99_02960 ENOG4105QAX Iron-sulfur HVX99_02965 ENOG4105C3J Cysteine desulfurase HVX99_02970 ENOG4107QY8 reductase HVX99_02975 ENOG4105KBG Protein of unknown function (DUF1161) HVX99_02980 ENOG4105D69 UPF0257 lipoprotein ynfC HVX99_02985 ENOG4108MK9 spermidine N(1)-acetyltransferase HVX99_03000 ENOG4105CXK mandelate racemase muconate lactonizing HVX99_03005 ENOG4105CPQ Dehydrogenase HVX99_03015 ENOG4107R08 Integrase HVX99_03030 ENOG4106G8A Qin prophage HVX99_03050 ENOG41087BU transcriptional repressor DicA HVX99_03095 ENOG4105K4U addiction module toxin, RelE StbE family HVX99_03115 ENOG4108MXB Protein of unknown function (DUF968) HVX99_03120 ENOG4105HGD Antitermination protein HVX99_03135 ENOG4105VEQ Cold shock protein HVX99_03140 ENOG4105QFS Lysis protein S homolog from lambdoid prophage HVX99_03155 ENOG4108YV9 Protein of unknown function (DUF2514) HVX99_03160 ENOG4105VEQ Cold shock protein HVX99_03175 ENOG4106IAW HVX99_03180 ENOG4106H71 Overexpression increases levels of unsaturated fatty acids and suppresses both the temperature-sensitive fabA6 mutation and cold-sensitive secG null mutation HVX99_03215 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) HVX99_03290 ENOG410685N tail fiber protein HVX99_03295 ENOG4105UZW Tail fiber assembly protein HVX99_03300 ENOG4105MN3 Resolvase HVX99_03305 ENOG4105W3V DNA-binding, transcriptional regulator HVX99_03320 ENOG4105DEI Mannitol dehydrogenase HVX99_03325 ENOG41061EV selenium-binding protein YdfZ HVX99_03330 ENOG4107XBN GntR Family Transcriptional Regulator HVX99_03335 ENOG4105EMU Dehydrogenase HVX99_03340 ENOG4105DGW oligopeptidase A HVX99_03345 ENOG4108WTK competence damage-inducible protein HVX99_03350 ENOG4108YDI single-species biofilm formation on inanimate substrate HVX99_03355 ENOG4105FSR swimming returnes to normal when residues 206-207 are both mutated to Ala. Overexpression also leads to a reduction in flagellar abundance and a 20-fold increase in c-di- GMP levels in vivo. Required for aminoglycoside-mediated induction of biofilm formation, it also plays a lesser role in biofilm production in response to other classes of translation inhibitors. The c-di-GMP produced by this enzyme up-regulates poly-GlcNAc production as well as the biofilm synthesis protein PgaD, although c-di-GMP is probably not the main inducing principle. Cyclic-di- GMP is a second messenger which controls cell surface-associated traits in bacteria HVX99_03365 ENOG4105E5W Transporter HVX99_03370 ENOG4108594 Permease of the drug metabolite transporter HVX99_03375 ENOG4105FDP GntR family transcriptional regulator HVX99_03385 ENOG4105CK1 PTS System HVX99_03390 ENOG4105VCP PTS System HVX99_03400 ENOG4105CS2 ec 3.2.1.21 HVX99_03405 ENOG4106DNR multiple antibiotic resistance protein HVX99_03410 ENOG4108XW0 May be a transcriptional activator of genes involved in the multiple antibiotic resistance (Mar) phenotype. It can also activate genes such as sodA, zwf and micF HVX99_03415 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes HVX99_03435 ENOG4105EGI Transcriptional regulator HVX99_03440 ENOG4105C26 Dehydrogenase HVX99_03445 ENOG4105CSV Glutaminase HVX99_03450 ENOG4105M0C cytoplasmic protein HVX99_03455 ENOG4105BZU Histidine kinase HVX99_03465 ENOG4105FFC UPF0187 protein HVX99_03475 ENOG4105K34 Involved in the degradation of phospho-AI-2, thereby terminating induction of the lsr operon and closing the AI-2 signaling cycle. Catalyzes the cleavage of phosphorylated 4,5- dihydroxy-2,3-pentanedione (P-DPD) to 2-phosphoglycolic acid (PG) and another three-carbon compound HVX99_03500 ENOG4105C2J ABC transporter HVX99_03520 ENOG41061P8 Persistence to inhibition of murein or DNA biosynthesis regulatory protein HVX99_03525 ENOG4105CAF HipA N-terminal domain protein HVX99_03535 ENOG4108RQP Major type 1 subunit fimbrin HVX99_03545 ENOG4105CW0 outer membrane usher protein HVX99_03550 ENOG4108WDE Fimbrial protein HVX99_03555 ENOG4106318 fimbrial-like protein YdeR HVX99_03560 ENOG4106PIH fimbrial-like protein ydeQ HVX99_03565 ENOG4107QKC Oxidoreductase alpha (molybdopterin) subunit HVX99_03580 ENOG4105ENH Sulfatase HVX99_03585 ENOG4105C4X radical SAM domain protein HVX99_03595 ENOG4105CQ0 ABC transporter HVX99_03600 ENOG4105PE1 Receptor HVX99_03605 ENOG4107RAN Peptidase, M16 HVX99_03610 ENOG4105CVK Glutamate decarboxylase HVX99_03615 ENOG4105E5D amino acid HVX99_03620 ENOG4105F32 YngK protein HVX99_03635 ENOG4105BZU Histidine kinase HVX99_03640 ENOG4108UQS dipeptidase HVX99_03645 ENOG4105DEF Extracellular solute-binding protein, family 5 HVX99_03650 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HVX99_03655 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HVX99_03660 ENOG4105C3U ABC transporter HVX99_03665 ENOG4107H6U ABC transporter HVX99_03670 ENOG4108Z9K Osmotically inducible protein HVX99_03675 ENOG4105TPS biofilm-dependent modulation protein HVX99_03680 ENOG4107AV5 Although this protein associates with the 30S subunit of the ribosome it is not considered to be a bona fide ribosomal protein HVX99_03690 ENOG4105DQ4 alcohol dehydrogenase HVX99_03695 ENOG41084S7 Plasmid maintenance system antidote protein HVX99_03700 ENOG4108MG3 formate dehydrogenase HVX99_03705 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein HVX99_03715 ENOG4105RPH Inner membrane protein YddG HVX99_03725 ENOG4108UI3 Leucine Rich repeat HVX99_03730 ENOG4107QND Nitrite extrusion protein HVX99_03735 ENOG4105CRU nitrate reductase, alpha subunit HVX99_03740 ENOG4108IUE nitrate reductase beta subunit HVX99_03745 ENOG4108NZN Respiratory nitrate reductase 2 delta chain HVX99_03750 ENOG4105D0D Nitrate reductase 2, gamma subunit HVX99_03755 ENOG4105JAB phenazine biosynthesis protein, phzf family HVX99_03760 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase HVX99_03765 ENOG4108MEJ flavin reductase domain protein HVX99_03795 ENOG4105CNA YD repeat protein HVX99_03800 ENOG4105CS6 Rhs element vgr protein HVX99_03810 ENOG4108N27 Glutathione S-transferase HVX99_03815 ENOG4105C85 amino acid HVX99_03820 ENOG4108NS2 receptor HVX99_03825 ENOG4105CHB tonB-dependent Receptor HVX99_03830 ENOG4108WYP Transcriptional regulator HVX99_03835 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein HVX99_03840 ENOG4108Z7F N-acetyltransferase HVX99_03845 ENOG4108T9Y Inner membrane protein ydcZ HVX99_03850 ENOG4105R71 cytoplasmic protein HVX99_03855 ENOG410654E Membrane HVX99_03875 ENOG4105NRK Binding-protein-dependent transport systems, inner membrane component HVX99_03880 ENOG4105D81 ABC transporter, permease HVX99_03885 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HVX99_03890 ENOG4107TYH extracellular solute-binding protein family 1 HVX99_03895 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HVX99_03900 ENOG4105PF0 Antitoxin component of a toxin-antitoxin (TA) module. Functions as an mRNA interferase antitoxin HVX99_03910 ENOG4105RR0 Protein of unknown function (DUF2554) HVX99_03915 ENOG4105CFP Peptidase U32 HVX99_03920 ENOG4108JCI Transcriptional regulator HVX99_03925 ENOG4105DKK Benzoate HVX99_03930 ENOG4105D7V transposase HVX99_03940 ENOG4108KKZ (LipO)protein HVX99_03945 ENOG41088CC tellurite resistance protein tehB HVX99_03950 ENOG4108NKP c4-dicarboxylate transporter malic acid transport protein HVX99_03955 ENOG4107WE3 acetyltransferase YdcK HVX99_03960 ENOG4108Z9I -acetyltransferase HVX99_03965 ENOG4105Z2P Protein of unknown function (DUF465) HVX99_03975 ENOG4105E32 cytoplasmic protein HVX99_03980 ENOG4105DDW LysR family Transcriptional regulator HVX99_03985 ENOG4105C8Q Methyl-accepting chemotaxis HVX99_03990 ENOG4107NK6 Hok/gef family HVX99_03995 ENOG4105UPP uncharacterized protein ydcA HVX99_04000 ENOG4105CPW cytochrome b561 HVX99_04005 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase HVX99_04010 ENOG4105C26 Dehydrogenase HVX99_04015 ENOG4107DB1 DUF218 domain HVX99_04020 ENOG4105CQ7 ATP-dependent helicase HVX99_04030 ENOG41077RS Phosphatase HVX99_04035 ENOG4105E8V Alpha Beta Hydrolase Fold protein HVX99_04040 ENOG4108HPI phosphatidate Cytidylyltransferase HVX99_04045 ENOG4108UMZ Cdp-alcohol phosphatidyltransferase HVX99_04055 ENOG4107S5I aldo keto reductase HVX99_04060 ENOG4108Z0R Transferase HVX99_04065 ENOG4105V9J phenylacetic acid degradation operon negative regulatory protein HVX99_04070 ENOG4105DZS Phenylacetate-CoA ligase HVX99_04075 ENOG4105CHU acetyl-coa acetyltransferase HVX99_04080 ENOG4108ZJI phenylacetic acid degradation protein HVX99_04085 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase HVX99_04090 ENOG4108UKI Enoyl-CoA hydratase HVX99_04095 ENOG4105E39 Enoyl-CoA hydratase HVX99_04100 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) HVX99_04105 ENOG4108ZA2 phenylacetate-CoA oxygenase PaaJ subunit HVX99_04110 ENOG4105D9S phenylacetate-CoA oxygenase PaaI subunit HVX99_04115 ENOG4105N76 Phenylacetate-CoA oxygenase, subunit HVX99_04120 ENOG4105CRS phenylacetate-CoA oxygenase PaaG subunit HVX99_04125 ENOG4105DXM phenylacetic acid degradation protein HVX99_04130 ENOG4105F11 amine oxidase HVX99_04135 ENOG4105C26 Dehydrogenase HVX99_04140 ENOG4108WFR AraC Family Transcriptional Regulator HVX99_04145 ENOG4105WXT Conserved Protein HVX99_04150 ENOG410689M (LipO)protein HVX99_04155 ENOG4107H52 Dicarboxylate transport HVX99_04160 ENOG4105C5I Dehydrogenase HVX99_04165 ENOG41090X5 Heat shock protein hslJ HVX99_04170 ENOG4105IKK cytoplasmic protein HVX99_04175 ENOG4105D95 Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity) HVX99_04180 ENOG4105FCK Membrane HVX99_04185 ENOG4108RW8 Universal stress protein F HVX99_04195 ENOG4105DIK (ABC) transporter HVX99_04200 ENOG4105CC5 ABC transporter HVX99_04205 ENOG4105CC5 ABC transporter HVX99_04210 ENOG4105UZW Tail fiber assembly protein HVX99_04215 ENOG410685N tail fiber protein HVX99_04330 ENOG4108ES9 ParB domain protein nuclease HVX99_04335 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) HVX99_04345 ENOG4105KUS lysozyme HVX99_04350 ENOG4105QFS Lysis protein S homolog from lambdoid prophage HVX99_04360 ENOG4108Z82 Cell envelope integrity inner membrane protein TolA HVX99_04370 ENOG4105RWQ Protein of unknown function (DUF1364) HVX99_04405 ENOG4105JBR DNA replication protein HVX99_04410 ENOG4105ZTP Protein of unknown function (DUF1376) HVX99_04445 ENOG4107C82 Rac prophage HVX99_04455 ENOG41076J9 exonuclease VIII HVX99_04460 ENOG4108PNI recT protein HVX99_04465 ENOG4106YAH restriction alleviation and modification enhancement HVX99_04470 ENOG41070YT Rac prophage HVX99_04475 ENOG4107160 Rac prophage HVX99_04480 ENOG4107R08 Integrase HVX99_04490 ENOG4105C1J atp-dependent rna helicase HVX99_04500 ENOG4105BZU Histidine kinase HVX99_04505 ENOG4108DG9 Smr protein MutS2 HVX99_04510 ENOG4106KR7 LysR family Transcriptional regulator HVX99_04515 ENOG4105CH2 amidohydrolase HVX99_04520 ENOG4107RT5 aminobenzoyl-glutamate utilization protein B HVX99_04525 ENOG4105CFC Transporter HVX99_04530 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) HVX99_04535 ENOG4105DS0 Transcriptional regulator, Crp Fnr family HVX99_04540 ENOG4105Q9Y Universal stress protein HVX99_04545 ENOG4105S5I Membrane HVX99_04550 ENOG4105D64 Mechanosensitive ion channel HVX99_04555 ENOG4107QSI ABC, transporter HVX99_04560 ENOG4105EQ2 LysR family Transcriptional regulator HVX99_04565 ENOG4105ENX hydrolase HVX99_04570 ENOG4105ENX hydrolase HVX99_04580 ENOG4105KXI murein peptide amidase A HVX99_04585 ENOG4107S8C mandelate racemase muconate lactonizing HVX99_04590 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) HVX99_04595 ENOG4108JU8 Transcriptional regulator HVX99_04605 ENOG4105CM6 amino acid regulated cytosolic protein HVX99_04610 ENOG4105FKQ transcriptional regulator HVX99_04615 ENOG4107EFV Outer membrane protein G HVX99_04620 ENOG4108IJ9 (ABC) transporter HVX99_04625 ENOG4107URF beta-phospho-glucomutase HVX99_04630 ENOG4105C71 hydrolase family 65, central catalytic HVX99_04640 ENOG4107TYA transient receptor potential locus HVX99_04645 ENOG4107RRD Dehydrogenase HVX99_04650 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component HVX99_04655 ENOG4105HS6 binding-protein-dependent transport systems inner membrane Component HVX99_04660 ENOG4105WEM extracellular solute-binding protein HVX99_04665 ENOG4107QW3 Sucrose phosphorylase HVX99_04670 ENOG4105K8Z Phage shock protein HVX99_04675 ENOG4105NNG Peripheral inner membrane phage-shock protein HVX99_04680 ENOG4105FM1 phage shock protein C HVX99_04685 ENOG4105YYT phage shock protein B HVX99_04690 ENOG41087YS Phage shock protein A HVX99_04695 ENOG4105E51 psp operon transcriptional activator HVX99_04700 ENOG4108JPW Aminotransferase HVX99_04705 ENOG4105CJP fad dependent oxidoreductase HVX99_04710 ENOG4105C26 Dehydrogenase HVX99_04715 ENOG4107VRI Transcriptional regulator HVX99_04720 ENOG4108Z86 Glutamine amidotransferase HVX99_04725 ENOG4105CFQ glutamine synthetase HVX99_04735 ENOG4105CUB amino acid HVX99_04740 ENOG4105N0E Protein of unknown function (DUF2543) HVX99_04745 ENOG4108HIY periplasmic HVX99_04750 ENOG4108I5W peptide transport system, permease protein HVX99_04755 ENOG4108EU3 peptide transport system, permease HVX99_04760 ENOG4108JQ3 Peptide ABC transporter ATP-binding protein HVX99_04765 ENOG4108JQ2 peptide transport system atp-binding protein HVX99_04770 ENOG4105WDY DNA (cytosine-5-)-methyltransferase HVX99_04775 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH HVX99_04780 ENOG4105Q4T oxidoreductase HVX99_04795 ENOG4105BZU Histidine kinase HVX99_04800 ENOG410643D UPF0509 protein HVX99_04805 ENOG4105N2W Transcriptional regulator HVX99_04815 ENOG4108ZJT translation initiation factor, Sui1 HVX99_04825 ENOG4105CFV Tetratricopeptide repeat protein HVX99_04830 ENOG4105Q4A inner membrane protein yciS HVX99_04835 ENOG4105EYK Phosphatidylglycerophosphatase B HVX99_04845 ENOG4107QM5 aconitate hydratase HVX99_04865 ENOG4107R11 Transcriptional regulator HVX99_04870 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) HVX99_04875 ENOG4105RKX Protein of unknown function (DUF2498) HVX99_04880 ENOG4105ERU peptidase HVX99_04885 ENOG4105UBK short-chain dehydrogenase reductase HVX99_04890 ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase HVX99_04895 ENOG4105FE9 pseudouridine synthase HVX99_04900 ENOG4107RTD sua5 ycio yrdc ywlc family protein HVX99_04905 ENOG4105DB7 PHP domain protein HVX99_04915 ENOG4105CRQ synthase (Component I) HVX99_04920 ENOG4108EFP Anthranilate synthase component II HVX99_04925 ENOG4105DK0 Indole-3-glycerol phosphate synthase HVX99_04945 ENOG4108Z9Z response to DNA damage stimulus HVX99_04950 ENOG4108N8X transition metal ion binding HVX99_04955 ENOG4105EIF outer membrane protein W HVX99_04975 ENOG4105NAU thioesterase Superfamily protein HVX99_04980 ENOG410822N TonB family HVX99_04985 ENOG4105K9H YciI-like protein HVX99_04990 ENOG4107SVH Potassium channel protein HVX99_05010 ENOG4108JQ7 (ABC) transporter HVX99_05015 ENOG4105C3U ABC transporter HVX99_05020 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HVX99_05025 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HVX99_05030 ENOG4108J59 Extracellular solute-binding protein, family 5 HVX99_05040 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein HVX99_05045 ENOG4105C0A alcohol dehydrogenase HVX99_05050 ENOG4107104 thymidine kinase HVX99_05055 ENOG4108SAU DNA-binding protein H-ns HVX99_05060 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase HVX99_05065 ENOG4105I93 response regulator HVX99_05070 ENOG4105D78 K07001 NTE family protein HVX99_05075 ENOG4105K5B UPF0225 protein HVX99_05080 ENOG4105CIY formyltetrahydrofolate deformylase HVX99_05110 ENOG41076YT nitrate reductase, gamma subunit HVX99_05115 ENOG4105R3A Nitrate reductase HVX99_05120 ENOG4108IUE nitrate reductase beta subunit HVX99_05125 ENOG4105CRU nitrate reductase, alpha subunit HVX99_05130 ENOG4105DQQ Major facilitator superfamily MFS_1 HVX99_05135 ENOG4105BZU Histidine kinase HVX99_05140 ENOG4105WH1 Two component transcriptional regulator luxr family HVX99_05145 ENOG4105ID0 Putative invasin HVX99_05150 ENOG41090EX DsrE family HVX99_05155 ENOG4108NH8 Cation transport protein HVX99_05160 ENOG4105WS7 Cation transport regulator HVX99_05165 ENOG4105EWV Sodium calcium exchanger membrane region HVX99_05190 ENOG41063JG Transcriptional regulator HVX99_05195 ENOG4108YY7 Invasion gene expression up-regulator SirB HVX99_05200 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) HVX99_05225 ENOG4105C5T Phosphoribosyl pyrophosphate synthase HVX99_05230 ENOG4105CHH sulfate transporter HVX99_05235 ENOG4105MGX transcription activated by CRP (cyclic AMP receptor protein), a global transcription factor involved in regulation of metabolism in enteric bacteria HVX99_05245 ENOG4105C3G gtp-binding protein HVX99_05250 ENOG4105I1J Autotransporter HVX99_05255 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family HVX99_05260 ENOG4105CMT Dihydroxyacetone kinase HVX99_05265 ENOG4108UTZ Dihydroxyacetone kinase HVX99_05270 ENOG4105VDH Dihydroxyacetone kinase HVX99_05290 ENOG4108T7K Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Increasing levels of c-di-GMP lead to decreased motility (By similarity) HVX99_05300 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A HVX99_05310 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) HVX99_05320 ENOG4105ED1 spovr family HVX99_05335 ENOG410635M Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein (By similarity) HVX99_05340 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) HVX99_05345 ENOG4105KT5 UmuD protein HVX99_05360 ENOG4105FBJ fumarylacetoacetate (faa) hydrolase HVX99_05370 ENOG41066UD Inhibits activity of g-type lysozyme, which confers increased lysozyme tolerance to the bacterium HVX99_05375 ENOG4105S66 prophage protein HVX99_05385 ENOG4107QMS site-determining protein HVX99_05420 ENOG410658X HVX99_05440 ENOG4105BZU Histidine kinase HVX99_05445 ENOG410738I uncharacterized protein ymgC HVX99_05455 ENOG41077SS Probably a connector protein for RcsB C regulation of biofilm formation, providing additional signal input into the two- component signaling pathway. May serve to stimulate biofilm maturation, probably via the Rcs phosphorelay. Mild overexpression at 16 degrees Celsius increases the production of colanic acid, an exopolysaccharide and matrix component, and reduces adhesive curli fimbriae expression. Both of these effects require RcsB HVX99_05460 ENOG4105WKE Probably a connector protein for RcsB C regulation of biofilm formation, providing additional signal input into the two- component signaling pathway. Partially antagonizes the activities of YmgA and AriR, proteins that, via the Rcs phosphorelay, promote the synthesis of colanic acid, an exopolysaccharide and matrix component HVX99_05465 ENOG4105BZU Histidine kinase HVX99_05470 ENOG4108XDN Transcriptional regulator HVX99_05475 ENOG41064WM Uncharacterized protein YcgX HVX99_05495 ENOG4108HMX isocitrate dehydrogenase (NADP) HVX99_05500 ENOG4108R4U Hnh endonuclease HVX99_05505 ENOG4108C33 Resolvase HVX99_05515 ENOG4108US3 tail fiber assembly HVX99_05520 ENOG4105PTU response to oxidative stress HVX99_05525 ENOG4105Y9F tail fiber protein HVX99_05530 ENOG4105Y0G tail protein HVX99_05535 ENOG4108T86 baseplate J family protein HVX99_05555 ENOG4108NKR DNA circulation protein HVX99_05580 ENOG4105TKZ Tail Sheath HVX99_05625 ENOG4105EFC phage portal protein HK97 family HVX99_05635 ENOG4105CAR Terminase, large subunit HVX99_05690 ENOG4108MXB Protein of unknown function (DUF968) HVX99_05700 ENOG4106CZA Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC (By similarity) HVX99_05730 ENOG4108S1U HVX99_05760 ENOG4105H40 HVX99_05765 ENOG4108HJ1 Uncharacterized conserved protein (DUF2303) HVX99_05770 ENOG4108R7K Metal Dependent Phosphohydrolase HVX99_05775 ENOG4105QYW Excisionase-like protein from lambdoid prophage 14 HVX99_05780 ENOG4108I1J Integrase HVX99_05790 ENOG4108HMX isocitrate dehydrogenase (NADP) HVX99_05795 ENOG4108R99 pseudouridine synthase HVX99_05815 ENOG4107QTF adenylosuccinate lyase HVX99_05820 ENOG4105XJC Two component transcriptional regulator (Winged helix family HVX99_05825 ENOG4105IFJ Histidine kinase HVX99_05830 ENOG4105EZE Cupin 4 family protein HVX99_05850 ENOG4105D38 putrescine abc transporter HVX99_05855 ENOG4107RUE extracellular solute-binding protein family 1 HVX99_05870 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) HVX99_05880 ENOG4105D60 lipoprotein releasing system transmembrane protein HVX99_05885 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) HVX99_05890 ENOG4105D60 lipoprotein releasing system transmembrane protein HVX99_05895 ENOG4105IQC Inner membrane protein YcfT HVX99_05900 ENOG4108JA2 transcriptioN-repair coupling factor HVX99_05905 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein HVX99_05910 ENOG4105RC8 Reduces the permeability of the outer membrane to copper. Seems to be involved in the regulation of biofilm formation. May decrease biofilm formation by repressing cell-cell interaction and cell surface interaction HVX99_05915 ENOG4108IND Tetr family transcriptional regulator HVX99_05920 ENOG4107MBR 17 kDa surface antigen HVX99_05925 ENOG4105CEP NADH dehydrogenase HVX99_05945 ENOG4108WEF Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b) (By similarity) HVX99_05950 ENOG41090DQ Lipoprotein HVX99_05955 ENOG4105K59 histidine triad (HIT) protein HVX99_05960 ENOG4105CNM Receptor HVX99_05965 ENOG4105CI1 PTS System HVX99_05970 ENOG4105F8V Hydrolase, tatD family HVX99_05975 ENOG4107QRG dna polymerase iii HVX99_05985 ENOG4105HHA aminodeoxychorismate lyase HVX99_05990 ENOG4105YAZ 4-amino-4-deoxychorismate lyase HVX99_05995 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) HVX99_06000 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) HVX99_06005 ENOG4105CHR reductase HVX99_06010 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase HVX99_06030 ENOG4105FCQ metal-binding, possibly nucleic acid-binding protein HVX99_06035 ENOG4108UHJ MAF-like protein HVX99_06040 ENOG4105EI2 Pseudouridine synthase HVX99_06045 ENOG4107QQB Ribonuclease E HVX99_06050 ENOG4105DTJ flagellar hook-associated protein HVX99_06055 ENOG4105E1Q flagellar hook-associated protein HVX99_06060 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj HVX99_06075 ENOG4105CGA flagellar basal-body rod protein FlgG HVX99_06080 ENOG4108KPB Flagellar basal-body rod protein FlgF HVX99_06085 ENOG4105BZE flagellar hook protein, FlgE HVX99_06090 ENOG4105W00 Flagellar hook capping protein HVX99_06095 ENOG4108ZC9 flagellar basal-body rod protein flgc HVX99_06100 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) HVX99_06105 ENOG4105CKS Flagella basal body P-ring formation protein flgA HVX99_06110 ENOG4105M9M anti-sigma28 factor FlgM HVX99_06115 ENOG4105QVD Flagella synthesis protein FlgN HVX99_06120 ENOG4105CJR Integral membrane protein (MviN HVX99_06125 ENOG4105EP9 oxidoreductase HVX99_06135 ENOG4105D9U N-acetyltransferase HVX99_06145 ENOG4105E9S glutaredoxin 2 HVX99_06150 ENOG4105F3T (LipO)protein HVX99_06160 ENOG4105MEA DNA damage-inducible protein i HVX99_06165 ENOG4105PVA Biofilm formation regulatory protein BssS HVX99_06175 ENOG4106974 biofilm formation HVX99_06180 ENOG4105DS1 cytochrome b561 HVX99_06185 ENOG4108YYC ycei family HVX99_06195 ENOG4105D1S lipid A biosynthesis HVX99_06205 ENOG4108W47 Acidic protein msyB HVX99_06210 ENOG4105NAC (LipO)protein HVX99_06215 ENOG4105C3A Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs) (By similarity) HVX99_06220 ENOG4105DJ9 glucan biosynthesis protein HVX99_06230 ENOG4107RZC phospholipase d HVX99_06235 ENOG4108UVJ appr-1-p processing domain protein HVX99_06250 ENOG4105G76 Curli are coiled surface structures that assemble preferentially at growth temperatures below 37 degrees Celsius. Curli can bind to fibronectin HVX99_06255 ENOG4108U0V Curli are coiled surface structures that assemble preferentially at growth temperatures below 37 degrees Celsius. Curli can bind to fibronectin. The minor subunit is the nucleation component of curlin monomers HVX99_06260 ENOG41086KC Transcriptional regulator HVX99_06265 ENOG4108XDW curli assembly protein CsgE HVX99_06270 ENOG4108WYR Curli production assembly transport component, CsgF HVX99_06275 ENOG4105P8Q Curli production assembly transport component CsgG HVX99_06280 ENOG4108UQ5 membrane protein YcdZ HVX99_06285 ENOG4107XHZ cytoplasmic chaperone TorD family protein HVX99_06295 ENOG4105JPG D-isomer specific 2-hydroxyacid dehydrogenase HVX99_06305 ENOG4108T85 Membrane HVX99_06320 ENOG4105BZU Histidine kinase HVX99_06325 ENOG4108TUY outer membrane protein PgaA HVX99_06330 ENOG4107BJW polysaccharide deacetylase HVX99_06335 ENOG4105CND Glycosyl transferase, family 2 HVX99_06345 ENOG4105D5M phosphate starvation-inducible protein HVX99_06350 ENOG4105DBE peroxidase HVX99_06355 ENOG410650H (LipO)protein HVX99_06365 ENOG4105CK7 Sodium proline symporter HVX99_06375 ENOG4105C26 Dehydrogenase HVX99_06380 ENOG4108R86 Transcriptional regulator HVX99_06415 ENOG4105C2W permease HVX99_06420 ENOG4105XF5 Escherichia coli IMT2125 genomic chromosome, IMT2125 HVX99_06430 ENOG4105XH3 HVX99_06435 ENOG4105D6F Phosphatase HVX99_06460 ENOG4107QY8 reductase HVX99_06465 ENOG4105CUW cytochrome C-TYPE protein HVX99_06470 ENOG4106WF9 DNA-binding transcriptional regulator TorR HVX99_06475 ENOG4108SV3 Tmao reductase system periplasmic protein tort HVX99_06480 ENOG4105BZU Histidine kinase HVX99_06485 ENOG4105HEE Binding Domain protein HVX99_06490 ENOG4106H71 Overexpression increases levels of unsaturated fatty acids and suppresses both the temperature-sensitive fabA6 mutation and cold-sensitive secG null mutation HVX99_06505 ENOG4105VEQ Cold shock protein HVX99_06510 ENOG41060EU Cold shock-like protein HVX99_06520 ENOG4108Y9B (LipO)protein HVX99_06525 ENOG4108W78 Pfam:DUF1017 HVX99_06530 ENOG4105E3R (LipO)protein HVX99_06535 ENOG4105DAY polysaccharide export protein HVX99_06540 ENOG4107ZF2 Phosphatase HVX99_06550 ENOG4105D6F Phosphatase HVX99_06560 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii HVX99_06565 ENOG4105C4M (Ubiquinol oxidase) subunit I HVX99_06570 ENOG4105MVP hydrogenase-1 operon protein HyaF HVX99_06575 ENOG4108VXY Hydrogenase-1 operon protein HyaE HVX99_06580 ENOG4108USZ hydrogenase HVX99_06585 ENOG4105X7T Ni Fe-hydrogenase, b-type cytochrome subunit HVX99_06590 ENOG4105DPX Hydrogenase, large subunit HVX99_06595 ENOG4105E3S small subunit HVX99_06605 ENOG4105UZW Tail fiber assembly protein HVX99_06610 ENOG4108X9F tail fiber protein HVX99_06610 ENOG4108X9F tail fiber protein HVX99_06680 ENOG4105CCQ Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins (By similarity) HVX99_06770 ENOG4105KSK (crossover) junction endodeoxyribonuclease HVX99_06775 ENOG4108MXB Protein of unknown function (DUF968) HVX99_06840 ENOG4105W7J DNA binding HVX99_06845 ENOG410649Z repressor HVX99_06870 ENOG4106G8A Qin prophage HVX99_06890 ENOG4108MN8 Membrane HVX99_06895 ENOG4108Z0T Part of a sulfur-relay system (By similarity) HVX99_06900 ENOG4105VSY K01512 acylphosphatase EC 3.6.1.7 HVX99_06915 ENOG4105K4P CoA-binding domain protein HVX99_06930 ENOG41088T4 Helicase IV HVX99_06935 ENOG410901E Membrane HVX99_06940 ENOG4105EM2 membrane HVX99_06945 ENOG4108RZ1 DNA transformation protein HVX99_06955 ENOG4105UYK outer membrane protein a HVX99_06965 ENOG4105DAN ATP-dependent protease HVX99_06975 ENOG4105WFT During stationary phase, converts 70S ribosomes to an inactive dimeric form (100S ribosomes) (By similarity) HVX99_06980 ENOG4108Q2G (LipO)protein HVX99_06985 ENOG4105DY2 Paraquat-inducible protein b HVX99_06990 ENOG4105F1S paraquat-inducible protein a HVX99_06995 ENOG4105C5H ABC transporter HVX99_07005 ENOG4105QVC MOSC domain-containing protein HVX99_07010 ENOG4108T7E Contributes to the efficiency of the cell division process by stabilizing the polymeric form of the cell division protein FtsZ. Acts by promoting interactions between FtsZ protofilaments and suppressing the GTPase activity of FtsZ (By similarity) HVX99_07020 ENOG4106PH7 chaperone HVX99_07025 ENOG4105MX3 Fimbrial HVX99_07030 ENOG4105Q7J Fimbrial HVX99_07035 ENOG4108MDY Fimbrial HVX99_07040 ENOG4105CW0 outer membrane usher protein HVX99_07045 ENOG4106JJN Part of the elfADCG-ycbUVF fimbrial operon, which promotes adhesion of bacteria to different abiotic surfaces. Could be required for the biogenesis of the ElfA fimbriae HVX99_07050 ENOG41071VI Part of the elfADCG-ycbUVF fimbrial operon, which promotes adhesion of bacteria to different abiotic surfaces. ElfA is the major fimbrial subunit produced by this operon HVX99_07055 ENOG4108UZX fmn reductase HVX99_07060 ENOG4105GVF (ABC) transporter HVX99_07070 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component HVX99_07080 ENOG4105CD8 aminopeptidase N HVX99_07095 ENOG4105FCK Membrane HVX99_07100 ENOG4105CGF Aromatic amino acid aminotransferase HVX99_07110 ENOG4105C5X domain protein HVX99_07115 ENOG4105EAQ (twin-arginine translocation) pathway signal HVX99_07120 ENOG4105DIT ErfK YbiS YcfS YnhG family protein HVX99_07130 ENOG4105DAH Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF (By similarity) HVX99_07140 ENOG4106371 Methyltransferase HVX99_07145 ENOG4107S90 membrAne HVX99_07150 ENOG4107VR7 transferase activity, transferring phosphorus-containing groups HVX99_07165 ENOG4105T0Z Conserved Protein HVX99_07175 ENOG4105BZ1 (ABC) transporter HVX99_07180 ENOG4108EQH DNA internalization-related competence protein ComEC Rec2 HVX99_07190 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) HVX99_07200 ENOG4108K0D peptidase, M48 HVX99_07215 ENOG4107VMU Membrane HVX99_07220 ENOG4105DDY UPF0142 protein ycaO HVX99_07225 ENOG4105TMB Formate nitrite transporter HVX99_07230 ENOG4105C6N Formate acetyltransferase HVX99_07235 ENOG4105F1A Pyruvate formate-lyase HVX99_07240 ENOG4108X0B nad(p)h dehydrogenase (quinone) HVX99_07245 ENOG410642W LysR family Transcriptional regulator HVX99_07250 ENOG4105E5D amino acid HVX99_07260 ENOG4105CHJ isochorismatase hydrolase HVX99_07265 ENOG4107KGK dmso reductase anchor subunit HVX99_07270 ENOG4105QAX Iron-sulfur HVX99_07275 ENOG4107QY8 reductase HVX99_07285 ENOG4105D1H recombination factor protein RarA HVX99_07295 ENOG4105CNU cell division protein FtsK HVX99_07305 ENOG4105C3M thioredoxin reductase HVX99_07310 ENOG4108JJ9 ABC, transporter HVX99_07315 ENOG4108JJ8 (ABC) transporter HVX99_07325 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) HVX99_07335 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit HVX99_07345 ENOG4105VEQ Cold shock protein HVX99_07350 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) HVX99_07355 ENOG4105DJY efflux transporter, rnd family, mfp subunit HVX99_07360 ENOG4108MJ5 VirK protein HVX99_07365 ENOG4105CPB ATP-dependent endonuclease of the OLD family HVX99_07370 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) HVX99_07375 ENOG4105DWU Membrane HVX99_07385 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) HVX99_07390 ENOG4105C7K acetolactate synthase HVX99_07395 ENOG4105C5W Aldolase HVX99_07400 ENOG4105CGD Nad-dependent epimerase dehydratase HVX99_07405 ENOG4107VBM 3-beta hydroxysteroid dehydrogenase isomerase HVX99_07410 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase HVX99_07420 ENOG41064MM (LipO)protein HVX99_07425 ENOG4105E5Z arginine transporter ATP-binding subunit HVX99_07430 ENOG4106PMH Extracellular solute-binding protein family 3 HVX99_07435 ENOG4105GBT ABC transporter HVX99_07440 ENOG4105DMR ABC, transporter HVX99_07445 ENOG4106TNF Periplasmic binding protein HVX99_07455 ENOG4105RBQ inner membrane protein ybjO HVX99_07460 ENOG4105D38 putrescine abc transporter HVX99_07465 ENOG4105F38 ABC transporter, permease HVX99_07470 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HVX99_07475 ENOG4107RUE extracellular solute-binding protein family 1 HVX99_07480 ENOG4108RMJ sensory transduction regulator HVX99_07490 ENOG4108DBC nitroreductase HVX99_07495 ENOG4105X20 member of the soxRS regulon which mediates in part the increased levels of superoxide in response to oxidative stress HVX99_07500 ENOG41090BQ Glutaredoxin HVX99_07505 ENOG4105GWF inner membrane protein YbjM HVX99_07515 ENOG4105ZTC transcriptional activator, Ogr delta HVX99_07555 ENOG4108C33 Resolvase HVX99_07570 ENOG4105PTU response to oxidative stress HVX99_07575 ENOG4108US3 tail fiber assembly HVX99_07665 ENOG4105ED4 portal protein HVX99_07685 ENOG4105VZ1 Replication Protein HVX99_07690 ENOG4105DFE Dna adenine methylase HVX99_07695 ENOG4105KSC Transcriptional regulator, TraR DksA family HVX99_07720 ENOG4105MEH HVX99_07750 ENOG4108RFG Tetr family transcriptional regulator HVX99_07755 ENOG4106UW1 Major Facilitator superfamily HVX99_07760 ENOG4108HCJ Hydrolase HVX99_07770 ENOG4107QF7 multi-drug HVX99_07775 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase HVX99_07780 ENOG4107FB0 transcriptional regulator DeoR family HVX99_07785 ENOG4105DZ1 carboxypeptidase HVX99_07790 ENOG4108TGY Glutathione S-transferase HVX99_07795 ENOG4105D8V Glucose sorbosone dehydrogenase HVX99_07800 ENOG4105UFT Represses biofilm formation in M9C glu and LB glu media but not in M9C and LB media. Seems to act as a global regulator of several genes involved in catabolite repression and stress response and regulation of the uptake and export of signaling pathways. Could be involved the regulation of indole as well as uptake and export of AI-2 through a cAMP-dependent pathway HVX99_07810 ENOG41064RH membrane protein YliF HVX99_07815 ENOG4105BZU Histidine kinase HVX99_07840 ENOG4105D44 asparaginase HVX99_07845 ENOG4105CVM Molybdenum cofactor synthesis domain protein HVX99_07850 ENOG4105D06 uba thif-type nad fad binding protein HVX99_07855 ENOG4107T9Z Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) HVX99_07860 ENOG4105F1A Pyruvate formate-lyase HVX99_07870 ENOG4108HCJ Hydrolase HVX99_07875 ENOG41072TH Protein of unknown function (DUF1479) HVX99_07880 ENOG4105C5H ABC transporter HVX99_07885 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein HVX99_07890 ENOG4105F4P )-transporter HVX99_07895 ENOG4105KST dependent repressor HVX99_07905 ENOG4108I6E Sulfatase HVX99_07910 ENOG4108T1M outer membrane protein x HVX99_07920 ENOG4107AQZ Membrane HVX99_07930 ENOG4107R0W ABC transporter HVX99_07935 ENOG4105E5Q amino acid AbC transporter HVX99_07940 ENOG4105CDA abc transporter atp-binding protein HVX99_07945 ENOG4105D8X mechanosensitive ion channel HVX99_07955 ENOG4105ZY9 UPF0379 protein ybiM HVX99_07960 ENOG4108IU3 tonb-dependent siderophore receptor HVX99_07970 ENOG4105KSC Transcriptional regulator, TraR DksA family HVX99_07975 ENOG4105VR4 UPF0379 protein ybiJ HVX99_07980 ENOG4105DG4 malate L-lactate dehydrogenase HVX99_07985 ENOG4108MTB glycosyl transferase family HVX99_07990 ENOG4105DVT helicase HVX99_07995 ENOG4108UV1 cellular component movement HVX99_08000 ENOG4105C1J atp-dependent rna helicase HVX99_08005 ENOG4107MVR Transcriptional regulator HVX99_08015 ENOG4105CJ1 ABC, transporter HVX99_08020 ENOG4107QWP ABC-2 type transporter HVX99_08025 ENOG4107QWP ABC-2 type transporter HVX99_08030 ENOG4105I9U inner membrane protein ybhQ HVX99_08035 ENOG4105X23 Endonuclease Exonuclease phosphatase HVX99_08040 ENOG4105DZQ phospholipase D Transphosphatidylase HVX99_08045 ENOG4107UXM Membrane HVX99_08050 ENOG410733J conserved inner membrane protein HVX99_08055 ENOG4105HFZ Membrane HVX99_08060 ENOG4108ZAF Molybdopterin HVX99_08065 ENOG4105M00 molybdopterin converting factor, subunit 1 HVX99_08075 ENOG4108RIR Molybdenum cofactor biosynthesis protein HVX99_08085 ENOG4105CHW UPF0052 protein HVX99_08095 ENOG4105E78 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) HVX99_08100 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) HVX99_08115 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) HVX99_08120 ENOG4108V1U phospholipid-binding protein HVX99_08125 ENOG4105NBR Pectinesterase HVX99_08130 ENOG4107QM5 aconitate hydratase HVX99_08135 ENOG4107QPK )-transporter HVX99_08140 ENOG4105C7F AcnD-accessory protein PrpF HVX99_08145 ENOG4105F04 LysR family Transcriptional regulator HVX99_08155 ENOG4108K4B hydrolase HVX99_08165 ENOG4105E0C molybdate abc transporter HVX99_08170 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein HVX99_08180 ENOG4105F4R Transcriptional regulator mode HVX99_08185 ENOG4105DKW ABC transporter HVX99_08190 ENOG4105CMR udp-glucose 4-epimerase HVX99_08195 ENOG4105F0Z galactose-1-phosphate uridylyltransferase HVX99_08205 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) HVX99_08215 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) HVX99_08220 ENOG4105JND homeobox protein HVX99_08225 ENOG4105PGM cation diffusion facilitator family transporter HVX99_08230 ENOG4106Z1T Nicotinamide Mononucleotide Transporter HVX99_08275 ENOG4105UFD tol-pal system protein YbgF HVX99_08280 ENOG4105KCK Peptidoglycan-associated lipoprotein HVX99_08290 ENOG4108Z82 Cell envelope integrity inner membrane protein TolA HVX99_08300 ENOG4105E02 MotA TolQ exbB proton channel HVX99_08305 ENOG4107YD3 Thioesterase HVX99_08310 ENOG4105KJB cyd operon protein YbgE HVX99_08320 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii HVX99_08325 ENOG4105C4M (Ubiquinol oxidase) subunit I HVX99_08330 ENOG4105C8I hydrolase, family 38 HVX99_08335 ENOG4105DM4 PTS System HVX99_08340 ENOG4105FDP GntR family transcriptional regulator HVX99_08345 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha HVX99_08355 ENOG4105C7S Dehydrogenase HVX99_08360 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 HVX99_08365 ENOG4105E33 succinate dehydrogenase HVX99_08370 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) HVX99_08375 ENOG4105N1I succinate dehydrogenase, hydrophobic membrane anchor protein HVX99_08380 ENOG4108UTY succinate dehydrogenase, cytochrome b556 subunit HVX99_08390 ENOG4105BZN citrate synthase HVX99_08395 ENOG4106UBK fimbrial-like adhesin protein HVX99_08400 ENOG4106PG1 outer membrane usher protein HVX99_08405 ENOG4108TTM chaperone HVX99_08410 ENOG4108MY7 Fimbrial HVX99_08415 ENOG4108KK1 membrane protein AbrB duplication HVX99_08430 ENOG4107R7A Allophanate hydrolase subunit 2 HVX99_08435 ENOG4105P4J Allophanate hydrolase, subunit 1 HVX99_08440 ENOG4107QNR UPF0135 protein HVX99_08445 ENOG4105DUX Transporter HVX99_08450 ENOG4105CVP deoxyribo-dipyrimidine photolyase HVX99_08455 ENOG4107SEY Conserved Protein HVX99_08470 ENOG4106R09 HVX99_08475 ENOG4105CNA YD repeat protein HVX99_08480 ENOG41079JQ Membrane HVX99_08485 ENOG4105CNA YD repeat protein HVX99_08490 ENOG4105XIQ Protein of unknown function (DUF2517) HVX99_08515 ENOG4105C08 Histidine kinase HVX99_08520 ENOG4105EEX Two component transcriptional regulator (Winged helix family HVX99_08530 ENOG4105CXN decarboxylase HVX99_08535 ENOG4105D5Q Arginine ornithine antiporter HVX99_08540 ENOG4107QIX Phosphoglucomutase (EC 5.4.2.2 HVX99_08545 ENOG4107CDU Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated (By similarity) HVX99_08550 ENOG4105EV9 Alpha Beta Hydrolase HVX99_08555 ENOG4105NNH LexA regulated protein HVX99_08560 ENOG4105MHQ Low-potential electron donor to a number of redox enzymes (By similarity) HVX99_08570 ENOG41090R7 Ferric uptake HVX99_08575 ENOG4105GX6 (LipO)protein HVX99_08590 ENOG4105CI1 PTS System HVX99_08600 ENOG4105CE4 GlcNAc 6-P deacetylase HVX99_08605 ENOG4105E2R ROK family HVX99_08610 ENOG4105D4U had-superfamily hydrolase, subfamily iia HVX99_08615 ENOG4105CAQ asparagine synthetase HVX99_08655 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family HVX99_08665 ENOG4105C9A Phoh family HVX99_08675 ENOG4108JU5 Magnesium and cobalt efflux protein HVX99_08680 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) HVX99_08690 ENOG4107RP9 extracellular solute-binding protein, family 3 HVX99_08695 ENOG4105EAD ABC transporter HVX99_08700 ENOG4105DRP amino acid AbC transporter HVX99_08705 ENOG4105CDA abc transporter atp-binding protein HVX99_08715 ENOG4105F7F Chaperone HVX99_08720 ENOG4105QFC Hsc56 co-chaperone of HscC HVX99_08725 ENOG41069CF Protein of unknown function (DUF1266) HVX99_08730 ENOG4107JFD Sel1 repeat HVX99_08735 ENOG4105QFC Hsc56 co-chaperone of HscC HVX99_08740 ENOG41069CF Protein of unknown function (DUF1266) HVX99_08745 ENOG4105EUU Sel1 domain protein repeat-containing protein HVX99_08750 ENOG4107PAI alpha helical protein HVX99_08765 ENOG4105DJF DNA polymerase III, delta' subunit HVX99_08775 ENOG4108TGR phosphatase HVX99_08780 ENOG4105KEM Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) HVX99_08790 ENOG4105CJN penicillin-binding protein HVX99_08795 ENOG4105CNI cell division protein FtsW HVX99_08800 ENOG4105K6T rare lipoprotein A HVX99_08805 ENOG4105DZ1 carboxypeptidase HVX99_08820 ENOG41064T2 transcriptional regulator, lysR family HVX99_08830 ENOG410607N Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatE shares overlapping functions with TatA (By similarity) HVX99_08850 ENOG41079UR PagP is required both for biosynthesis of hepta-acylated lipid A species containing palmitate and for resistance to cationic antimicrobial peptides (CAMPs). It catalyzes the transfer of a palmitate chain (16 0) from the sn-1 position of a glycerophospholipid to the free hydroxyl group of the (R)-3- hydroxymyristate chain at position 2 of lipid A (endotoxin) (By similarity) HVX99_08855 ENOG4105CEE C4-dicarboxylate transporter HVX99_08860 ENOG4106YYS transcriptional regulatory protein HVX99_08865 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism HVX99_08870 ENOG4105DUA (citrate (pro-3S)-lyase ligase HVX99_08880 ENOG4105CI0 Citrate lyase HVX99_08885 ENOG4105CHY citrate lyase, alpha HVX99_08900 ENOG4107QPK )-transporter HVX99_08905 ENOG4105KTS ribonuclease HVX99_08910 ENOG4105NXH GreA GreB family elongation factor HVX99_08915 ENOG4105E2A Dehydrogenase HVX99_08920 ENOG4108U51 Universal stress protein HVX99_08925 ENOG4108JU3 Alkyl hydroperoxide reductase HVX99_08930 ENOG4105D3R alkyl hydroperoxide reductase HVX99_08935 ENOG4108KHN disulfide isomerase, thiol-disulfide oxidase HVX99_08940 ENOG4105DQS Transcriptional regulator HVX99_08945 ENOG4105BZV Phosphoadenosine phosphosulfate reductase HVX99_08950 ENOG4105GTN ParB Domain Protein Nuclease HVX99_08955 ENOG4105CHM Aminotransferase HVX99_08960 ENOG4107SCQ Iron-containing alcohol dehydrogenase HVX99_08965 ENOG4105VCD cytoplasmic protein HVX99_08970 ENOG4105D22 carbon starvation protein HVX99_08975 ENOG4108TZA Required for optimal enterobactin synthesis. Acts as a proofreading enzyme that prevents EntB misacylation by hydrolyzing the thioester bound existing between EntB and wrongly charged molecules (By similarity) HVX99_08980 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase HVX99_08985 ENOG4105WQI isochorismatase HVX99_08990 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase HVX99_08995 ENOG4105E4F Isochorismate synthase HVX99_09000 ENOG4105PEC Iron-enterobactin transporter periplasmic binding protein HVX99_09010 ENOG4105DQ5 transport system permease protein HVX99_09015 ENOG4105TVJ transport system, permease HVX99_09020 ENOG4105E0A ABC, transporter HVX99_09025 ENOG4108QY5 Ferric enterobactin transport protein HVX99_09030 ENOG4105C0W non-ribosomal peptide synthetase HVX99_09035 ENOG41085A6 mbth domain-containing protein HVX99_09040 ENOG4105E93 esterase HVX99_09045 ENOG4107RNH Outer membrane receptor FepA HVX99_09050 ENOG4108TSE Transferase HVX99_09060 ENOG4107635 Hok Gef family protein HVX99_09070 ENOG4105WQ6 Membrane HVX99_09075 ENOG4105MSB protein, conserved in bacteria HVX99_09080 ENOG4108RCM Nitroreductase HVX99_09085 ENOG4105CUY Mechanosensitive ion channel HVX99_09090 ENOG4105C85 amino acid HVX99_09095 ENOG4108IJF Heavy metal efflux pump, CzcA HVX99_09100 ENOG4105EP1 Efflux transporter rnd family, mfp subunit HVX99_09105 ENOG410624V efflux system protein HVX99_09110 ENOG4105ENJ RND efflux system, outer membrane lipoprotein HVX99_09115 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HVX99_09120 ENOG4105GR3 Histidine kinase HVX99_09125 ENOG4105CS6 Rhs element vgr protein HVX99_09150 ENOG410600T transposase HVX99_09155 ENOG410802X bacteriophage n4 adsorption protein b HVX99_09160 ENOG41090FC Bacteriophage N4 receptor, outer membrane subunit HVX99_09165 ENOG4105QUW HVX99_09175 ENOG4108NC2 Outer membrane protease HVX99_09190 ENOG4108WF3 methyltransferase HVX99_09195 ENOG4105UZW Tail fiber assembly protein HVX99_09200 ENOG410685N tail fiber protein HVX99_09295 ENOG4105IM0 capsid protein HVX99_09355 ENOG4105DFP Integrase HVX99_09370 ENOG4105F7J membrane-bound serine protease HVX99_09380 ENOG4107DE1 head-to-tail joining protein HVX99_09385 ENOG4105UZW Tail fiber assembly protein HVX99_09390 ENOG4105FKG DNA packaging protein HVX99_09395 ENOG4106YSC HVX99_09400 ENOG4105QYK bacteriophage lambda Bor protein homolog HVX99_09410 ENOG4105KUS lysozyme HVX99_09415 ENOG4105QFS Lysis protein S homolog from lambdoid prophage HVX99_09425 ENOG4105HRS Antitermination protein HVX99_09440 ENOG4105RWQ Protein of unknown function (DUF1364) HVX99_09445 ENOG410757E Protein NinE homolog from lambdoid prophage DLP12 HVX99_09450 ENOG4108V2F protein ybcN in lambdoid DLP12 prophage regi HVX99_09560 ENOG4108KU3 Integrase HVX99_09570 ENOG4108Q9V regulatoR HVX99_09575 ENOG4108ZI2 Fimbrial protein HVX99_09580 ENOG4108M66 Involved in regulation of length and mediation of adhesion of SfmA fimbriae (but not necessary for the production of fimbriae). Seems to be mannose binding adhesin (By similarity) HVX99_09590 ENOG4108AF8 Chaperone HVX99_09595 ENOG4108WDE Fimbrial protein HVX99_09605 ENOG4105WQ3 Rna-binding protein HVX99_09610 ENOG4105S2T inner membrane protein YbcI HVX99_09620 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) HVX99_09630 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) HVX99_09635 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit HVX99_09640 ENOG4105C5B carbamate kinase HVX99_09645 ENOG4105G5A Protein of unknown function (DUF2877) HVX99_09650 ENOG4107REC cytoplasmic protein HVX99_09655 ENOG4107R1Q Membrane protein FdrA HVX99_09660 ENOG4105DG4 malate L-lactate dehydrogenase HVX99_09665 ENOG4105CE7 Amidase, hydantoinase carbamoylase family HVX99_09670 ENOG4105S0E allantoin catabolism protein HVX99_09675 ENOG4105BZW Glycerate kinase HVX99_09680 ENOG4105DTE Xanthine uracil vitamin C permease HVX99_09690 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease HVX99_09695 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase HVX99_09700 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) HVX99_09705 ENOG41060W2 glyoxylate carboligase HVX99_09710 ENOG4108N16 Negative regulator of allantoin and glyoxylate utilization operons. Binds to the gcl promoter and to the allS- allA intergenic region HVX99_09720 ENOG4107653 Transcriptional regulator HVX99_09740 ENOG4105CNA YD repeat protein HVX99_09745 ENOG4105CV6 ABC transporter, permease HVX99_09750 ENOG4108I0Y (ABC) transporter HVX99_09755 ENOG4108UJV acyl-CoA thioesterase i HVX99_09760 ENOG4105E1F short-chain dehydrogenase reductase HVX99_09765 ENOG4107QR8 Thioredoxin HVX99_09770 ENOG4105C4B ABC transporter, permease HVX99_09775 ENOG41083J0 (ABC) transporter HVX99_09780 ENOG4107QX8 SPFH domain, Band 7 family protein HVX99_09785 ENOG4105G5H Membrane HVX99_09790 ENOG4108Z6Z Transcriptional regulator HVX99_09795 ENOG4107RY6 amino acid HVX99_09800 ENOG4105CSV Glutaminase HVX99_09805 ENOG4105C59 p-type ATPase HVX99_09810 ENOG41081XE plasmid maintenance system antidote protein, xre family HVX99_09815 ENOG4105MBR gumn family HVX99_09820 ENOG4108Z66 YbaK ebsC protein HVX99_09825 ENOG4105CGH 5'-nucleotidase HVX99_09830 ENOG4105EU0 Major facilitator Superfamily HVX99_09835 ENOG4105CKD glutathione-regulated potassium-efflux system protein HVX99_09840 ENOG4107RE1 Inosine-guanosine kinase HVX99_09875 ENOG4107QMP dna polymerase iii subunits gamma and tau HVX99_09885 ENOG4105WD1 Membrane HVX99_09890 ENOG4108URS primosomal replication protein n'' HVX99_09895 ENOG4106428 Protein of unknown function (DUF2496) HVX99_09900 ENOG4105EGS Mechanosensitive ion channel HVX99_09905 ENOG4107XI7 Tetr family transcriptional regulator HVX99_09910 ENOG4105C1P efflux transporter, rnd family, mfp subunit HVX99_09915 ENOG4105BZS acriflavin resistance protein HVX99_09920 ENOG4108UKR Biofilm formation regulator YbaJ HVX99_09925 ENOG4105KF5 hemolysin expression-modulating protein HVX99_09930 ENOG4108UW5 maltose o-acetyltransferase HVX99_09935 ENOG4105GSJ Inner membrane protein ylaC HVX99_09940 ENOG41066DG (EAL) domain protein HVX99_09945 ENOG4105KCV RNA signal recognition particle 4.5S RNA HVX99_09955 ENOG41080UX Methyltransferase HVX99_09960 ENOG4108MNP Glycoprotein polysaccharide metabolism HVX99_09965 ENOG4105C29 acyl-CoA thioesterase HVX99_09970 ENOG4105BZU Histidine kinase HVX99_09975 ENOG4108YZA Nitrogen regulatory protein pii HVX99_09980 ENOG4105BZ1 (ABC) transporter HVX99_09985 ENOG4105BZ1 (ABC) transporter HVX99_09990 ENOG4108XM1 transcriptional regulator AsnC family HVX99_10000 ENOG4108NFA extracellular solute-binding protein HVX99_10010 ENOG4108TGP Thioesterase superfamily protein HVX99_10015 ENOG41083P1 competence protein ComEA helix-hairpin-helix repeat protein HVX99_10020 ENOG4105EIN peptidylprolyl cis-trans isomerase HVX99_10025 ENOG4105K70 DNA-binding protein HVX99_10030 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) HVX99_10050 ENOG4105M85 Bola protein HVX99_10055 ENOG4105IEY (LipO)protein HVX99_10060 ENOG4105EYM Major Facilitator superfamily HVX99_10065 ENOG4105E2S oxidase) subunit II HVX99_10070 ENOG4105BZ9 Cytochrome C oxidase, subunit I HVX99_10075 ENOG4105CCU oxidase (Subunit III) HVX99_10080 ENOG41090KH cytochrome o ubiquinol oxidase (subunit iv) HVX99_10105 ENOG4107RDB Major Facilitator HVX99_10115 ENOG4108JZF Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) HVX99_10120 ENOG4107S0N DJ-1 family HVX99_10135 ENOG4105CTB Polyprenyl synthetase HVX99_10145 ENOG4105CPC Aldo Keto reductase HVX99_10150 ENOG4108ZAI phosphatidylglycerophosphatase a HVX99_10155 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) HVX99_10165 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) HVX99_10170 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) HVX99_10180 ENOG4108KIC (LipO)protein HVX99_10185 ENOG4105DRB nucleoside-specific channel-forming protein HVX99_10190 ENOG4105N1F Hnh endonuclease HVX99_10195 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) HVX99_10200 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) HVX99_10205 ENOG4105VIE preprotein translocase, subunit YajC HVX99_10225 ENOG4107R28 alpha amylase, catalytic region HVX99_10230 ENOG4105C85 amino acid HVX99_10235 ENOG4105CWM branched-chain amino acid transport system II carrier protein HVX99_10240 ENOG4105BZU Histidine kinase HVX99_10245 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HVX99_10250 ENOG4107RH8 nuclease SbcCD subunit D HVX99_10255 ENOG4105EYH Exonuclease HVX99_10260 ENOG4105F27 Major Facilitator HVX99_10265 ENOG4105DKQ ROK family HVX99_10290 ENOG4105HBA AroM protein HVX99_10295 ENOG4105SS3 HVX99_10310 ENOG4105II7 pyrroline-5-carboxylate reductase HVX99_10315 ENOG4105BZU Histidine kinase HVX99_10320 ENOG4105VIF phosphate starvation-inducible protein HVX99_10325 ENOG4105G6Z alkaline phosphatase HVX99_10340 ENOG4105CPF Cell wall formation (By similarity) HVX99_10345 ENOG4105UNH Membrane HVX99_10350 ENOG4105FR5 inner membrane protein YaiY HVX99_10355 ENOG4107QS8 (LipO)protein HVX99_10360 ENOG4108DQG in Escherichia coli SbmA is involved in uptake of microcin J25 HVX99_10365 ENOG4107R6D beta-lactam binding protein AmpH HVX99_10370 ENOG4108PNB DNA-binding transcriptional regulator HVX99_10380 ENOG4105D52 delta-aminolevulinic acid dehydratase HVX99_10385 ENOG4105E2B Taurine dioxygenase HVX99_10390 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component HVX99_10400 ENOG4106FTQ Taurine ABC transporter, periplasmic HVX99_10405 ENOG4107W19 lmbE family HVX99_10410 ENOG4108PBI Polysaccharide metabolism HVX99_10420 ENOG4105SRB Uncharacterized protein yaiO HVX99_10440 ENOG4105IUQ nucleoprotein polynucleotide-associated enzyme HVX99_10445 ENOG4108SC4 )-transporter HVX99_10480 ENOG4108K2P TRANSCRIPTIONal HVX99_10485 ENOG4105ETE Transcriptional regulator (LacI family HVX99_10495 ENOG4105U0F oligosaccharide H symporter, major facilitator superfamily (MFS) HVX99_10500 ENOG4105DJ2 Major Facilitator Superfamily HVX99_10510 ENOG4107B2H carbonic anhydrase HVX99_10515 ENOG4105DND Transcriptional regulator HVX99_10520 ENOG4105DZC cytosine deaminase HVX99_10525 ENOG4105DQW permease for cytosine purines, uracil, thiamine, allantoin HVX99_10530 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) HVX99_10535 ENOG4105DXD 2-methylcitrate dehydratase HVX99_10540 ENOG4105BZN citrate synthase HVX99_10545 ENOG4105CR4 methylisocitrate lyase HVX99_10550 ENOG4108JU7 Transcriptional regulator HVX99_10555 ENOG4105TDT uncharacterized protein yahO HVX99_10560 ENOG4105E82 cytochrome subunit of dehydrogenase HVX99_10575 ENOG4105DQ4 alcohol dehydrogenase HVX99_10580 ENOG4105CNN ABC, transporter HVX99_10585 ENOG4105CNN ABC, transporter HVX99_10590 ENOG4105C2J ABC transporter HVX99_10595 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator HVX99_10605 ENOG4105DZC cytosine deaminase HVX99_10610 ENOG4105C5B carbamate kinase HVX99_10620 ENOG4107REC cytoplasmic protein HVX99_10625 ENOG4107R1Q Membrane protein FdrA HVX99_10630 ENOG4105N16 Protein of unknown function (DUF2877) HVX99_10635 ENOG4107SNB ankyrin repeat protein YahD HVX99_10640 ENOG4105SZ2 membrAne HVX99_10645 ENOG4108NUU Transcriptional regulator HVX99_10650 ENOG4105BZU Histidine kinase HVX99_10660 ENOG4105C94 Transporter HVX99_10675 ENOG4105CZ6 Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine (By similarity) HVX99_10685 ENOG4108ZZK Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source (By similarity) HVX99_10690 ENOG4107QR9 Iron-sulfur cluster binding protein HVX99_10695 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) HVX99_10700 ENOG4108K01 transcriptional regulator HVX99_10705 ENOG4107QN2 dihydrolipoyl dehydrogenase HVX99_10710 ENOG41066GK UPF0379 protein ykgI HVX99_10715 ENOG4108KBJ Inner membrane protein YkgB HVX99_10720 ENOG4105CV8 reductase HVX99_10760 ENOG4108GWT fimbrillin MatB HVX99_10770 ENOG4108N3D putative enzyme HVX99_10775 ENOG4106PYX Receptor HVX99_10780 ENOG4108UD7 cell wall organization HVX99_10785 ENOG4105PI0 Ferredoxin HVX99_10790 ENOG4105R3P Inner membrane protein yagU HVX99_10795 ENOG4107XKX isoquinoline 1-oxidoreductase, alpha subunit HVX99_10800 ENOG4105DIP Molybdopterin dehydrogenase FAD-binding HVX99_10805 ENOG4105C7W Xanthine dehydrogenase HVX99_10810 ENOG4107XAN XdhC and CoxI family HVX99_10835 ENOG4105FCK Membrane HVX99_10855 ENOG4105CIN aminoacyl-histidine dipeptidase HVX99_10860 ENOG4108S2Y peptide Chain Release factor HVX99_10870 ENOG4108HYG acetyltransferase HVX99_10875 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) HVX99_10900 ENOG4108YS0 lipoprotein YafL HVX99_10910 ENOG4105VXN addiction module toxin, RelE StbE family HVX99_10915 ENOG4105F7V ErfK ybiS ycfS ynhG family protein HVX99_10920 ENOG4105E7A Glutamine amidotransferase HVX99_10930 ENOG4107QPN acyl-Coa dehydrogenase HVX99_10935 ENOG4108WN0 inhibitor of vertebrate lysozyme HVX99_10940 ENOG4105CZ7 nitrilase cyanide hydratase and apolipoprotein n-acyltransferase HVX99_10965 ENOG4105CNA YD repeat protein HVX99_10970 ENOG4105CS6 Rhs element vgr protein HVX99_10975 ENOG4108WC9 type VI secretion system effector, hcp1 family HVX99_11030 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit HVX99_11055 ENOG4105GMB type VI secretion system effector, hcp1 family HVX99_11070 ENOG410600K aminopeptidase HVX99_11080 ENOG4107RZZ dna polymerase iii epsilon subunit HVX99_11090 ENOG4105D1A Methyltransferase HVX99_11100 ENOG4105E9H Lytic Murein transglycosylase HVX99_11105 ENOG4105F2W methyltransferase HVX99_11115 ENOG4105HEI LysR family (Transcriptional regulator HVX99_11120 ENOG4105CV8 reductase HVX99_11155 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase HVX99_11160 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) HVX99_11165 ENOG4108UMI ABC transporter, permease HVX99_11170 ENOG4105D01 (LipO)protein HVX99_11175 ENOG4108R8X outer membrane lipoprotein HVX99_11180 ENOG4108R96 Methyltransferase, YaeB family HVX99_11190 ENOG4108UY0 (LipO)protein HVX99_11200 ENOG4107EII Lipoprotein involved with copper homeostasis and adhesion HVX99_11205 ENOG4108YZN class I peptide chain release factor HVX99_11210 ENOG4108VWS Yaeq family HVX99_11220 ENOG4105M1T rho-binding antiterminator HVX99_11225 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) HVX99_11230 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase HVX99_11235 ENOG4105CXN decarboxylase HVX99_11245 ENOG4105C0B DNA polymerase III (alpha subunit) HVX99_11270 ENOG4105D7M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) HVX99_11275 ENOG4108RFI Molecular chaperone that interacts specifically with outer membrane proteins, thus maintaining the solubility of early folding intermediates during passage through the periplasm (By similarity) HVX99_11285 ENOG4105DZP Membrane-associated zinc metalloprotease HVX99_11290 ENOG4105KNE Phosphatidate cytidylyltransferase HVX99_11295 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) HVX99_11300 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) HVX99_11325 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) HVX99_11345 ENOG4108IXP Carbohydrate diacid transcriptional activator CdaR HVX99_11350 ENOG4105C0H protease HVX99_11365 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) HVX99_11370 ENOG4105EN6 Membrane HVX99_11395 ENOG4105S6R Iron-hydroxamate transporter permease subunit HVX99_11400 ENOG4105J76 Periplasmic binding protein HVX99_11405 ENOG4105E0A ABC, transporter HVX99_11410 ENOG4105E0K tonB-dependent siderophore receptor HVX99_11415 ENOG4105BZ4 penicillin-binding protein HVX99_11420 ENOG4105CQ7 ATP-dependent helicase HVX99_11425 ENOG4107XID 2'-5' rna ligase HVX99_11445 ENOG4105DJ0 Poly(A) Polymerase HVX99_11450 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase HVX99_11460 ENOG4108VEV chaperone HVX99_11465 ENOG4105CW0 outer membrane usher protein HVX99_11470 ENOG4108XEY fimbrial-like adhesin protein HVX99_11475 ENOG4105SYG Fimbrial protein HVX99_11480 ENOG4105SN2 fimbrial-like adhesin protein HVX99_11485 ENOG4105P0Q fimbrial-like protein YadC HVX99_11510 ENOG4107BJW polysaccharide deacetylase HVX99_11515 ENOG4108YTN IIa component HVX99_11520 ENOG4105E3A (ABC) transporter HVX99_11525 ENOG4105DA5 (ABC) transporter HVX99_11530 ENOG41077A9 carbonic anhydrase HVX99_11535 ENOG4108UGV hypoxanthine phosphoribosyltransferase HVX99_11540 ENOG4105DZG Dehydrogenase HVX99_11545 ENOG4105E3B Multicopper oxidase HVX99_11550 ENOG4108ZRK uncharacterized protein yacC HVX99_11570 ENOG4107QIJ Aconitate hydratase 2 HVX99_11575 ENOG4108NST exported protein HVX99_11580 ENOG4107QN2 dihydrolipoyl dehydrogenase HVX99_11585 ENOG4107QSN dihydrolipoamide acetyltransferase HVX99_11590 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) HVX99_11595 ENOG41073TP transcriptional regulator HVX99_11600 ENOG4105C85 amino acid HVX99_11605 ENOG4106A72 regulatory protein AmpE HVX99_11610 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase HVX99_11615 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase HVX99_11620 ENOG4108ZUW Major pilin subunit HVX99_11625 ENOG4107QHF type ii secretion system protein e HVX99_11630 ENOG4105D7Q type ii secretion system HVX99_11645 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) HVX99_11665 ENOG4105M6F mutator MutT protein HVX99_11675 ENOG4108SR7 Regulates secA expression by translational coupling of the secM secA operon. Translational pausing at a specific Pro residue 5 residues before the end of the protein may allow disruption of a mRNA repressor helix that normally suppresses secA translation initiation (By similarity) HVX99_11685 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) HVX99_11690 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) HVX99_11695 ENOG4105K7E Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity) HVX99_11700 ENOG4105CPF Cell wall formation (By similarity) HVX99_11715 ENOG4105CNI cell division protein FtsW HVX99_11730 ENOG4108EQQ Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity) HVX99_11735 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) HVX99_11740 ENOG4105CJN penicillin-binding protein HVX99_11745 ENOG41063Y6 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) HVX99_11760 ENOG4107B7Y DNA-binding transcriptional regulator FruR HVX99_11770 ENOG4108ZP8 Acetolactate synthase small subunit HVX99_11775 ENOG4105C7K acetolactate synthase HVX99_11785 ENOG41064T2 transcriptional regulator, lysR family HVX99_11800 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) HVX99_11815 ENOG4105S8Q sugar efflux transporter HVX99_11830 ENOG4105DP9 ABC transporter HVX99_11835 ENOG4106SMU thiamine transporter membrane protein HVX99_11845 ENOG4108KF1 Membrane HVX99_11850 ENOG41063TF transcriptional regulator (AraC HVX99_11865 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase HVX99_11870 ENOG4105CQ2 DNA polymerase HVX99_11880 ENOG4105D3G Pseudouridine synthase HVX99_11885 ENOG41066UG Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host (By similarity) HVX99_11890 ENOG4105E7H involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity) HVX99_11895 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) HVX99_11920 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) HVX99_11935 ENOG4105C54 Major Facilitator superfamily HVX99_11940 ENOG4105IBM Could be part of an electron transfer system required for anaerobic carnitine reduction. Could be a 3Fe-4S cluster- containing protein HVX99_11945 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase HVX99_11980 ENOG4106YT9 Enoyl-CoA hydratase HVX99_11990 ENOG4108XNW Transcriptional activatory protein CaiF HVX99_11995 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain HVX99_12000 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain HVX99_12020 ENOG41090X3 Peptidyl-prolyl cis-trans isomerase HVX99_12030 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) HVX99_12035 ENOG4105DTN riboflavin biosynthesis protein ribF HVX99_12040 ENOG410647N response to DNA damage stimulus HVX99_12055 ENOG4105CW0 outer membrane usher protein HVX99_12070 ENOG41063Z6 transcriptional regulator, lysR family HVX99_12080 ENOG4105WI6 cell killing protein encoded within cryptic prophage HVX99_12100 ENOG4108QUJ UPF0174 protein YaaW HVX99_12105 ENOG4106HK8 GPR1 FUN34 yaaH family protein HVX99_12110 ENOG4108RIR Molybdenum cofactor biosynthesis protein HVX99_12120 ENOG4105BZG amino acid carrier protein HVX99_12135 ENOG41062C6 Protein of unknown function (DUF2502) HVX99_12140 ENOG4105D98 threonine synthase HVX99_12150 ENOG4105CFH Aspartokinase HVX99_12160 ENOG4106FVC RNA methyltransferase HVX99_12165 ENOG410759A HVX99_12170 ENOG41065U4 response regulator HVX99_12175 ENOG4105CT7 inner membrane cred family protein HVX99_12180 ENOG4105EB3 Histidine kinase HVX99_12185 ENOG4105E3W Two component transcriptional regulator (Winged helix family HVX99_12190 ENOG4108RH0 Crea protein HVX99_12195 ENOG4105UEI Transcriptional Regulator AraC Family HVX99_12215 ENOG4107SC1 transglycosylase HVX99_12220 ENOG4105C5H ABC transporter HVX99_12225 ENOG4107VZS Nicotinamide-nucleotide adenylyltransferase HVX99_12230 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) HVX99_12235 ENOG4105EAC phosphoserine phosphatase HVX99_12240 ENOG41062Z9 Membrane HVX99_12275 ENOG4105G0K glycine radical enzyme YjjI family HVX99_12280 ENOG41076CZ activating enzyme HVX99_12285 ENOG4105EYA deoxyribonuclease HVX99_12290 ENOG4108NRW Phospholipase, patatin family HVX99_12300 ENOG4105K3G Periplasmic Protein HVX99_12310 ENOG4105PAD Hydrolase HVX99_12315 ENOG4105KEG ribosomal-protein-alanine acetyltransferase HVX99_12320 ENOG4108WPU DNA polymerase III subunit psi HVX99_12345 ENOG4105YBH Protein of unknown function (DUF1435) HVX99_12350 ENOG4108819 ferric iron reductase HVX99_12355 ENOG4108T94 DNA-binding transcriptional activator BglJ HVX99_12360 ENOG4108N8T regulatoR HVX99_12365 ENOG4105DWK Membrane HVX99_12380 ENOG4106CVF DNA replication protein HVX99_12385 ENOG4105RI1 glycoprotein receptor HVX99_12395 ENOG4105CPQ Dehydrogenase HVX99_12400 ENOG410617M Transcriptional regulator HVX99_12405 ENOG4108I5G Major Facilitator superfamily HVX99_12410 ENOG4105C8Q Methyl-accepting chemotaxis HVX99_12415 ENOG4108V8F Transcriptional regulator, MarR family HVX99_12420 ENOG4105ERH Fumarylacetoacetate hydrolase HVX99_12425 ENOG4105C26 Dehydrogenase HVX99_12430 ENOG4107THI 3,4-dihydroxyphenylacetate 2,3-dioxygenase HVX99_12445 ENOG4105CNV Aldolase HVX99_12460 ENOG4105EFA 4-hydroxyphenylacetate HVX99_12465 ENOG4107UWN reductase HVX99_12470 ENOG4105D22 carbon starvation protein HVX99_12475 ENOG4105VCD cytoplasmic protein HVX99_12480 ENOG4105CKI cobalamin synthesis protein HVX99_12490 ENOG4106DIZ Domain of unknown function (DUF1127) HVX99_12495 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HVX99_12505 ENOG41083G8 Multidrug resistance protein MdtM HVX99_12515 ENOG4105DCU 2-hydroxyglutaryl-CoA dehydratase HVX99_12520 ENOG4105CIZ coA-substrate-specific enzyme activase HVX99_12535 ENOG4105CBP Major Facilitator HVX99_12545 ENOG41074DU domain protein HVX99_12550 ENOG4108P2H Inner membrane protein YjiG HVX99_12555 ENOG4105DYB Isoaspartyl dipeptidase HVX99_12560 ENOG4107YNJ LysR family Transcriptional regulator HVX99_12580 ENOG4105C6F GntR Family Transcriptional Regulator HVX99_12585 ENOG4105DEI Mannitol dehydrogenase HVX99_12595 ENOG4107EFN gluconate transport system permease 3 HVX99_12600 ENOG410643X FIMH SUBUNIT MANNOSE-sensitive type 1 fimbrial adhesin HVX99_12605 ENOG4108T65 Fimbrial HVX99_12610 ENOG4108SQA Fimbrial HVX99_12615 ENOG4105CW0 outer membrane usher protein HVX99_12620 ENOG4108NAE Fimbrial chaperone protein HVX99_12625 ENOG4108S54 Fimbrial protein HVX99_12635 ENOG4105E71 FimE is one of the 2 regulatory proteins which control the phase variation of type 1 fimbriae in E.coli. These proteins mediate the periodic inversion of a 300bp DNA segment that harbors the promoter for the fimbrial structural gene, fimA. FimE switches fimA off HVX99_12640 ENOG4108W9T type 1 fimbriae regulatory protein HVX99_12645 ENOG41069FU Outer membrane channel protein allowing the entry of N- acetylneuraminic acid (Neu5Ac, the most abundant sialic acid on host cell surfaces) into the bacteria HVX99_12670 ENOG4105FBQ ATPase associated with various cellular activities aaa_5 HVX99_12725 ENOG4105D9P serine threonine protein kinase HVX99_12810 ENOG4105DQ4 alcohol dehydrogenase HVX99_12815 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family HVX99_12820 ENOG4105CPQ Dehydrogenase HVX99_12825 ENOG4105CHR reductase HVX99_12830 ENOG4105C6Z Gluconate HVX99_12835 ENOG4105K2J Transcriptional regulator HVX99_12840 ENOG4105D7A ATP-binding protein HVX99_12845 ENOG4108K5H permease YjgP YjgQ family protein HVX99_12850 ENOG4108M8S permease YjgP YjgQ family protein HVX99_12860 ENOG4105MYG DNA polymerase iii, chi subunit HVX99_12865 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) HVX99_12870 ENOG4108M3P Membrane HVX99_12875 ENOG4108MJ3 acetyltransferase HVX99_12880 ENOG4105KQT Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome (By similarity) HVX99_12905 ENOG4105XEP YhcH YjgK YiaL family protein HVX99_12910 ENOG4108XFH Transcriptional regulator HVX99_12915 ENOG4105F6U Short-chain dehydrogenase reductase Sdr HVX99_12920 ENOG4108UQ8 endoribonuclease L-psp HVX99_12925 ENOG4107C93 pyrBI operon leader peptide HVX99_12940 ENOG4105KME endoribonuclease L-psp HVX99_12950 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic HVX99_12960 ENOG4105D4X repressor HVX99_12965 ENOG4105C5Y PTS System HVX99_12970 ENOG4105CG3 alpha amylase, catalytic region HVX99_12975 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase HVX99_12980 ENOG4108RDD Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine (By similarity) HVX99_12990 ENOG4105CMS peptidase U62, modulator of DNA gyrase HVX99_13000 ENOG4105DFU Cell wall formation (By similarity) HVX99_13010 ENOG41062B0 ABC transporter, permease HVX99_13015 ENOG4107R9N ABC transporter HVX99_13020 ENOG4105C2J ABC transporter HVX99_13025 ENOG4107R5U Periplasmic binding protein LacI transcriptional regulator HVX99_13030 ENOG4105F0N pyrophosphate phospho-hydrolase HVX99_13035 ENOG4105MZG transcriptional modulator of maze toxin, mazf HVX99_13040 ENOG41087RY SpoVT_AbrB HVX99_13045 ENOG4108ZHD aig2 family HVX99_13050 ENOG4105MA0 exported protein HVX99_13055 ENOG4105CFU surface antigen HVX99_13065 ENOG4105C37 (CBS) domain HVX99_13070 ENOG41061GZ Protein of unknown function (DUF1107) HVX99_13075 ENOG4108UUE Transcriptional regulator HVX99_13080 ENOG4108RNI 3'(2')5'-bisphosphate nucleotidase HVX99_13085 ENOG4107RNS bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase 3'-nucleotidase periplasmic HVX99_13090 ENOG4105KVH Transcriptional regulator HVX99_13095 ENOG4105ECR NmrA family HVX99_13100 ENOG4105DXC membrane HVX99_13120 ENOG4105C85 amino acid HVX99_13125 ENOG4108V1T peptidylprolyl cis-trans isomerase HVX99_13130 ENOG4105FHY Opacity-associated protein A HVX99_13140 ENOG4105CHR reductase HVX99_13150 ENOG4105E39 Enoyl-CoA hydratase HVX99_13155 ENOG4107R0K CoA transferase having broad substrate specificity for short-chain acyl-CoA thioesters with the activity decreasing when the length of the carboxylic acid chain exceeds four carbons (By similarity) HVX99_13160 ENOG4107S3R L-aspartate oxidase HVX99_13165 ENOG41069H7 transport system small permease component HVX99_13170 ENOG4105CG6 trap dicarboxylate transporter dctm subunit HVX99_13175 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit HVX99_13185 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) HVX99_13200 ENOG4105KIT UPF0379 protein yjfY HVX99_13230 ENOG4105CZC PTS system ascorbate-specific transporter subunit IIC HVX99_13245 ENOG4108MXZ Esterase HVX99_13250 ENOG4105WSB biofilm stress and motility protein A HVX99_13255 ENOG4105S17 UPF0379 protein yjfN HVX99_13260 ENOG4105CSU acyl-Coa dehydrogenase HVX99_13265 ENOG4106032 Glutathionylspermidine synthase HVX99_13270 ENOG4108KXT Conserved Protein HVX99_13275 ENOG4105Z6B inner membrane protein yjfl HVX99_13280 ENOG4107VNS Protein of unknown function (DUF2491) HVX99_13285 ENOG4108P9J Phage shock protein A HVX99_13290 ENOG4105FUX Conserved Protein HVX99_13295 ENOG4105C2N RNA methyltransferase TrmH family group 3 HVX99_13300 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) HVX99_13320 ENOG4105EPW hflc protein HVX99_13325 ENOG4107QJR hflk protein HVX99_13330 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) HVX99_13350 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase HVX99_13355 ENOG4105K8N protein family UPF0079, ATPase HVX99_13360 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) HVX99_13365 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) HVX99_13405 ENOG4105EGS Mechanosensitive ion channel HVX99_13410 ENOG4107SC7 Inner membrane transporter yjeM HVX99_13420 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) HVX99_13425 ENOG4105E33 succinate dehydrogenase HVX99_13440 ENOG41066YJ Beta-lactamase HVX99_13445 ENOG4105QNF Outer membrane lipoprotein HVX99_13450 ENOG4105KPY Small multidrug resistance protein HVX99_13455 ENOG4106BSU Entericidin B HVX99_13460 ENOG4107PEH Entericidin EcnA/B family HVX99_13470 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein HVX99_13475 ENOG4105MTB Uncharacterized protein YjeJ HVX99_13480 ENOG4108ZVF (LipO)protein HVX99_13495 ENOG4105DVH amino acid HVX99_13500 ENOG4108YH1 overproduction of this protein in Escherichia coli inhibits the F plasmid-mediated exclusion of bacteriophage T7 HVX99_13505 ENOG4108IJ0 Aspartate ammonia-lyase HVX99_13510 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter HVX99_13525 ENOG4108SIC Transcriptional regulator HVX99_13535 ENOG4108M3R transcriptional activator CadC HVX99_13540 ENOG4105D5Q Arginine ornithine antiporter HVX99_13545 ENOG4105CXN decarboxylase HVX99_13550 ENOG4105DUX Transporter HVX99_13555 ENOG4105CRK lysyL-tRNA synthetase HVX99_13570 ENOG410830R acetyltransferase HVX99_13575 ENOG4105VR1 Pfam:DUF1271 HVX99_13580 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism HVX99_13585 ENOG4108MRH transcriptional regulatory protein HVX99_13590 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter HVX99_13595 ENOG4107GFK fumarate HVX99_13600 ENOG4108R5S membrane HVX99_13605 ENOG4105CT4 transporter HVX99_13610 ENOG4105F8D glycoside hydrolase family 4 HVX99_13615 ENOG4108K2B transcriptional regulator HVX99_13620 ENOG4105CXN decarboxylase HVX99_13625 ENOG4106ZGR Transcriptional regulator HVX99_13630 ENOG4105D5Q Arginine ornithine antiporter HVX99_13635 ENOG4105DIJ Phosphoethanolamine transferase HVX99_13640 ENOG4105XJC Two component transcriptional regulator (Winged helix family HVX99_13645 ENOG4105ECM Sensor protein basS pmrB HVX99_13655 ENOG4105CSH Transporter HVX99_13660 ENOG4108YIV HVX99_13665 ENOG4108F5E vimentin HVX99_13670 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA HVX99_13675 ENOG4108SQ4 Glyoxalase Bleomycin resistance protein (Dioxygenase HVX99_13680 ENOG4105D5T phosphonate abc transporter HVX99_13685 ENOG4105EHI Phosphonate ABC transporter, periplasmic HVX99_13695 ENOG4107RJJ Transcriptional regulator HVX99_13700 ENOG4105KQZ Phosphonate C-P lyase system protein PhnG HVX99_13705 ENOG4105KZ6 phosphonate C-P lyase system protein PhnH HVX99_13710 ENOG4105EKV Phosphonate metabolism protein HVX99_13715 ENOG4105FT8 Phosphonate metabolism HVX99_13720 ENOG4105ENV phosphonate C-P lyase system protein PhnK HVX99_13725 ENOG4105HRV phosphonate c-p lyase system protein phnl HVX99_13730 ENOG4105FD8 phosphonate metabolism protein PhnM HVX99_13735 ENOG4105MFQ Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP) (By similarity) HVX99_13740 ENOG410849A acetyltransferase, (GNAT) family HVX99_13745 ENOG4107SA6 carbon-phosphorus lyase complex accessory protein HVX99_13755 ENOG4108YZG isomerase HVX99_13760 ENOG4105EUZ Beta-lactamase domain protein HVX99_13765 ENOG4106833 HVX99_13770 ENOG4105J12 Multidrug resistance protein mdtN HVX99_13775 ENOG4108MI0 Resistance protein HVX99_13780 ENOG4105ETP RND efflux system, outer membrane lipoprotein HVX99_13790 ENOG41082ND Uncharacterized protein yjcO HVX99_13795 ENOG4105CK2 sodium dicarboxylate symporter HVX99_13800 ENOG4108W0S formate-dependent nitrite reductase complex HVX99_13810 ENOG4108QKW cytochrome c-type biogenesis protein HVX99_13815 ENOG4105DVI reductase, NrfD HVX99_13820 ENOG4105D3S 4Fe-4S Ferredoxin, iron-sulfur binding domain protein HVX99_13825 ENOG4105JJ8 Cytochrome c nitrite reductase, pentaheme subunit HVX99_13835 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) HVX99_13840 ENOG41062QD Membrane HVX99_13855 ENOG4105EEQ Na H antiporter HVX99_13860 ENOG4105C7N Xanthine uracil vitamin C permease HVX99_13865 ENOG4108Z4X TRANSCRIPTIONal HVX99_13870 ENOG4108W3Q Transcriptional regulator HVX99_13880 ENOG4105PMV Membrane HVX99_13885 ENOG4108UUM single-stranded DNA-binding protein HVX99_13890 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) HVX99_13895 ENOG4105MSB protein, conserved in bacteria HVX99_13900 ENOG4108YXI Secondary thiamine-phosphate synthase enzyme HVX99_13905 ENOG4105F0S class B acid phosphatase HVX99_13915 ENOG4105CGF Aromatic amino acid aminotransferase HVX99_13920 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) HVX99_13925 ENOG4105CDU Replicative dna helicase HVX99_13930 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein HVX99_13935 ENOG4105P4Z Phage shock protein G HVX99_13940 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) HVX99_13950 ENOG4105MYN Zinc uptake regulation protein HVX99_13955 ENOG4105VDW Csbd family HVX99_13960 ENOG4107R73 Mate efflux family protein HVX99_13970 ENOG41080IJ Diacylglycerol kinase HVX99_13995 ENOG4107W52 maltose operon periplasmic protein HVX99_14005 ENOG4108IJ9 (ABC) transporter HVX99_14010 ENOG4107FKK extracellular solute-binding protein family 1 HVX99_14015 ENOG4105D56 permease protein HVX99_14020 ENOG4105EG2 ABC transporter, permease HVX99_14025 ENOG4107QNK )-transporter HVX99_14040 ENOG4105E3R (LipO)protein HVX99_14045 ENOG4108Q9C Periplasmic Protein HVX99_14050 ENOG4108MDC (LipO)protein HVX99_14065 ENOG4105CFH Aspartokinase HVX99_14070 ENOG4108WZA zeta toxin HVX99_14075 ENOG410756H nucleotidyltransferase HVX99_14085 ENOG4108ZR5 Conserved Protein HVX99_14090 ENOG4105FE9 pseudouridine synthase HVX99_14100 ENOG4105EAM Na Pi-cotransporter HVX99_14105 ENOG4105C3R Methionine synthase HVX99_14110 ENOG41069M3 Transcriptional regulator HVX99_14125 ENOG4108I9X Isocitrate lyase HVX99_14130 ENOG4107QP3 malate synthase g HVX99_14140 ENOG4105K5X acetyltransferase HVX99_14170 ENOG4105C12 Phosphoribosylglycinamide synthetase HVX99_14175 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family HVX99_14180 ENOG4105BZU Histidine kinase HVX99_14185 ENOG4105JBU Binds zinc. Could be an important component of the zinc- balancing mechanism HVX99_14190 ENOG4108T8B Protein of unknown function (DUF1481) HVX99_14200 ENOG4105R2J Conserved Protein HVX99_14235 ENOG4105D06 uba thif-type nad fad binding protein HVX99_14240 ENOG4105WHD thiamine biosynthesis protein ThiS HVX99_14250 ENOG4105D41 biosynthesis protein thiH HVX99_14255 ENOG410645W Thiamin biosynthesis protein ThiH HVX99_14290 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) HVX99_14295 ENOG4105PM1 preprotein translocase subunit SecE HVX99_14330 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase HVX99_14365 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) HVX99_14375 ENOG4108Y73 Membrane HVX99_14380 ENOG4105EJ2 Transcriptional regulator HVX99_14390 ENOG4105C5Q Transcriptional regulator HVX99_14405 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase HVX99_14420 ENOG4105DIJ Phosphoethanolamine transferase HVX99_14425 ENOG4106R3P AraC family transcriptional regulator HVX99_14430 ENOG4108XCZ PTS System HVX99_14435 ENOG4108AHH pyruvate formate lyase II activase HVX99_14445 ENOG4108YRF PTS System HVX99_14450 ENOG4105DM4 PTS System HVX99_14455 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) HVX99_14460 ENOG4107T9Z Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) HVX99_14465 ENOG4105DCT glycerol dehydrogenase HVX99_14470 ENOG4108XC3 NADH ubiquinone oxidoreductase HVX99_14475 ENOG4108Q5Y Membrane HVX99_14485 ENOG4105SYT Methylenetetrahydrofolate reductase HVX99_14490 ENOG4105CFH Aspartokinase HVX99_14495 ENOG4105C28 cystathionine HVX99_14505 ENOG4107S01 Repressor protein MetJ HVX99_14520 ENOG4105CNA YD repeat protein HVX99_14530 ENOG4105C25 Primosomal protein n' HVX99_14535 ENOG4105ETE Transcriptional regulator (LacI family HVX99_14540 ENOG41063M6 Cell Division Protein HVX99_14555 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase HVX99_14570 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) HVX99_14580 ENOG4105CBT Fructose-1,6-bisphosphatase HVX99_14585 ENOG4105DP0 ferredoxin-NADP reductase HVX99_14595 ENOG41065TG regulatoR HVX99_14600 ENOG4108VTS Membrane HVX99_14605 ENOG4105EBK exported protein HVX99_14620 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein HVX99_14635 ENOG4105FMW periplasmic HVX99_14640 ENOG4105E3W Two component transcriptional regulator (Winged helix family HVX99_14645 ENOG4105E0F Histidine kinase HVX99_14650 ENOG4108RPX mosc domain containing protein HVX99_14660 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) HVX99_14680 ENOG4105DET Rhamnulokinase HVX99_14700 ENOG41064BA PTS system, fructose-specific, IIA component HVX99_14705 ENOG4105DM4 PTS System HVX99_14710 ENOG4105CN9 Peptidase m42 family protein HVX99_14715 ENOG4106C3V frv operon regulatory protein HVX99_14720 ENOG4108V87 frv operon regulatory protein HVX99_14725 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) HVX99_14735 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein HVX99_14740 ENOG4108MG3 formate dehydrogenase HVX99_14755 ENOG41068KX affects formate dehydrogenase-N HVX99_14770 ENOG4105W2W Cytotoxic translational repressor of toxin-antitoxin stability system HVX99_14780 ENOG4105SUU thioesterase domain HVX99_14795 ENOG4105EJU HAD-superfamily hydrolase subfamily IA variant 3 HVX99_14805 ENOG4105CSH Transporter HVX99_14815 ENOG4105CPQ Dehydrogenase HVX99_14820 ENOG4105D2M Aldolase HVX99_14825 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase HVX99_14830 ENOG4108MGF sugar kinase HVX99_14835 ENOG4105E98 transcriptional regulator DeoR family HVX99_14840 ENOG4105R9B Major Facilitator HVX99_14845 ENOG4108KHF Resistance protein HVX99_14850 ENOG4108K85 Transcriptional regulator HVX99_14855 ENOG4105CI3 gtp-binding protein typa HVX99_14860 ENOG4105C5F glutamine synthetase HVX99_14865 ENOG4105CUX Signal transduction histidine kinase HVX99_14870 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family HVX99_14875 ENOG4106FIY HVX99_14880 ENOG4105D4P Coproporphyrinogen iii oxidase HVX99_14895 ENOG4105C2M dna polymerase I HVX99_14900 ENOG4106HNH Acyl-transferase HVX99_14910 ENOG4108Z33 Thiol disulfide Interchange Protein HVX99_14915 ENOG4105E27 serine threonine protein kinase HVX99_14920 ENOG4105PC1 Conserved Protein HVX99_14925 ENOG4105C6R Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) HVX99_14930 ENOG4105FNP Molybdopterin-guanine dinucleotide biosynthesis protein b HVX99_14960 ENOG4108RR8 protoporphyrinogen oxidase HVX99_14965 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) HVX99_14970 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein HVX99_14980 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase HVX99_14990 ENOG4108EX3 reductase HVX99_14995 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) HVX99_15000 ENOG4105MDZ Transcriptional activator rfaH HVX99_15010 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) HVX99_15015 ENOG4105X8U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity) HVX99_15020 ENOG4105WKS Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) HVX99_15030 ENOG4105JC1 sterol-binding domain protein HVX99_15040 ENOG4105CGY Dna recombination protein HVX99_15045 ENOG4108I5U Uridine phosphorylase HVX99_15050 ENOG4105CDZ Carboxymethylenebutenolidase (EC 3.1.1.45) HVX99_15060 ENOG4105DZ2 Transcriptional regulator HVX99_15065 ENOG4105EMK carboxylate amino acid amine transporter HVX99_15070 ENOG4105DQF Hydrolase HVX99_15075 ENOG4108EUD Lysophospholipase HVX99_15080 ENOG410829K Lysine exporter protein (Lyse ygga) HVX99_15085 ENOG4105CCF Lysine exporter protein (Lyse ygga) HVX99_15090 ENOG4105C9U ATP-dependent DNA helicase RecQ HVX99_15095 ENOG4105HDD phospholipase HVX99_15100 ENOG4108VUY thioesterase Superfamily protein HVX99_15105 ENOG4105FR1 rard protein HVX99_15115 ENOG4107QUT magnesium and cobalt transport protein CorA HVX99_15130 ENOG4107QUT magnesium and cobalt transport protein CorA HVX99_15135 ENOG4108T58 Mg2 transport protein CorA HVX99_15140 ENOG4105C4R Atp-dependent dna helicase HVX99_15145 ENOG4105DFC had-superfamily hydrolase, subfamily ia, variant HVX99_15155 ENOG4105CT0 Protein of unknown function, DUF484 HVX99_15165 ENOG4105S7Z (LipO)protein HVX99_15190 ENOG4107T0K Adenylate cyclase HVX99_15200 ENOG41076E6 Uroporphyrinogen-III Synthase HVX99_15205 ENOG4105ECF c-methyltransferase HVX99_15210 ENOG410601J HemY protein HVX99_15215 ENOG4105ENH Sulfatase HVX99_15220 ENOG4105C4X radical SAM domain protein HVX99_15245 ENOG4105C85 amino acid HVX99_15265 ENOG4105EGZ biosynthesis protein HVX99_15270 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase HVX99_15275 ENOG4108WJ1 acetyltransferase HVX99_15280 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) HVX99_15285 ENOG4105C1B dTDP-glucose 4-6-dehydratase HVX99_15290 ENOG4107QQG Dehydrogenase HVX99_15295 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase HVX99_15300 ENOG4105SFE lipopolysaccharide biosynthesis protein HVX99_15305 ENOG4105ESV Glycosyl transferase, family 4 HVX99_15310 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) HVX99_15335 ENOG4105C4R Atp-dependent dna helicase HVX99_15345 ENOG4105KQ5 peptidylprolyl cis-trans isomerase HVX99_15355 ENOG4105EMY transcriptional regulator HVX99_15360 ENOG4105C7B Threonine dehydratase HVX99_15370 ENOG4105CM2 brancheD-chain amino acid aminotransferase HVX99_15375 ENOG4105P3Y Acetolactate synthase 2 regulatory subunit HVX99_15395 ENOG4105C0P Mg chelatase subunit ChlI HVX99_15400 ENOG4108WFC UPF0438 protein yifE HVX99_15440 ENOG4107EJG GntR family transcriptional regulator HVX99_15445 ENOG4105C0R drug resistance transporter emrb qaca subfamily HVX99_15450 ENOG4105ETE Transcriptional regulator (LacI family HVX99_15455 ENOG4108RVA ribokinase HVX99_15460 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator HVX99_15465 ENOG4105CNN ABC, transporter HVX99_15470 ENOG4105C2J ABC transporter HVX99_15490 ENOG4105EV2 VWA domain protein interacting with AAA ATPase HVX99_15500 ENOG4108VVK transcriptional Regulator, AsnC HVX99_15505 ENOG4105QTB Flavodoxin HVX99_15520 ENOG4105GXX Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit I associates with the membrane and may be involved with cation translocation HVX99_15570 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) HVX99_15585 ENOG4105CW0 outer membrane usher protein HVX99_15595 ENOG4107QMV Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity) HVX99_15600 ENOG4105C8U phosphate abc transporter HVX99_15605 ENOG4105E2Z phosphate ABC transporter (Permease HVX99_15610 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) HVX99_15615 ENOG4108UTW Plays a role in the regulation of phosphate uptake HVX99_15620 ENOG4105CID antiterminator HVX99_15625 ENOG4105C5Y PTS System HVX99_15630 ENOG4105CS2 ec 3.2.1.21 HVX99_15640 ENOG4105DYC esterase HVX99_15645 ENOG4107VKM 6-phosphogluconolactonase HVX99_15650 ENOG4106611 bacteriocin immunity HVX99_15660 ENOG4107UB3 HAD-superfamily hydrolase subfamily IA variant 3 HVX99_15665 ENOG4105C7N Xanthine uracil vitamin C permease HVX99_15670 ENOG4108YYH Nadph-dependent fmn reductase HVX99_15675 ENOG4105E8Q phosphopantetheinyl transferase HVX99_15690 ENOG4108P6C Tryptophan transporter of low affinity HVX99_15705 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) HVX99_15725 ENOG4105VG0 50S ribosomal protein l34 HVX99_15740 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) HVX99_15750 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HVX99_15755 ENOG4105VP5 Bacterial protein of unknown function (DUF937) HVX99_15760 ENOG410667J hydrolase HVX99_15765 ENOG410657R replicase EC 2.7 HVX99_15770 ENOG4105EMF GntR family transcriptional regulator HVX99_15775 ENOG4105EI3 2-dehydro-3-deoxygalactonokinase EC 2.7.1.58 HVX99_15780 ENOG4108RTU Aldolase HVX99_15790 ENOG4105DJB Major Facilitator Superfamily HVX99_15800 ENOG4105D99 atp gtp-binding protein HVX99_15805 ENOG4105R2A (LipO)protein HVX99_15825 ENOG4105FDP GntR family transcriptional regulator HVX99_15830 ENOG4105CI1 PTS System HVX99_15840 ENOG4108AHD Transcriptional regulator HVX99_15845 ENOG4107RUZ Sss sodium solute transporter superfamily HVX99_15850 ENOG4105CBG Sulfatase HVX99_15855 ENOG4106DRA Inner membrane protein YidI HVX99_15860 ENOG4105VG5 Membrane HVX99_15865 ENOG4105JP4 Inner membrane protein yidG HVX99_15870 ENOG4105J13 transcriptional regulator HVX99_15875 ENOG4105E5M Multidrug resistance protein D HVX99_15890 ENOG4105C7K acetolactate synthase HVX99_15895 ENOG4105M71 acetolactate synthase 1 regulatory subunit HVX99_15900 ENOG4108KX4 response regulator HVX99_15905 ENOG4105BZU Histidine kinase HVX99_15910 ENOG4105CXY transporter HVX99_15915 ENOG4105CXY transporter HVX99_15925 ENOG4105C7N Xanthine uracil vitamin C permease HVX99_15930 ENOG4108SAJ Protein of unknown function (DUF1198) HVX99_15940 ENOG4105T8A Uncharacterized protein YicS HVX99_15945 ENOG4105D01 (LipO)protein HVX99_15950 ENOG4108UZ3 Transporter HVX99_15955 ENOG4105S8Q sugar efflux transporter HVX99_16015 ENOG4105DFP Integrase HVX99_16025 ENOG4105CT4 transporter HVX99_16030 ENOG4105CJQ hydrolase, family 31 HVX99_16035 ENOG4105JV1 AsmA family HVX99_16040 ENOG4105C2W permease HVX99_16045 ENOG4105D6U Sodium Glutamate Symporter HVX99_16055 ENOG4105CB5 ATP-dependent DNA helicase recG HVX99_16060 ENOG4105FE8 tRNA (Guanosine-2'-O-)-methyltransferase HVX99_16065 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) HVX99_16075 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) HVX99_16085 ENOG4105EN6 Membrane HVX99_16090 ENOG4105F5P DNA-damage-inducible protein d HVX99_16095 ENOG4105DSJ YicC domain protein HVX99_16115 ENOG4108Z1K This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) HVX99_16120 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase HVX99_16130 ENOG4105KDC 50s ribosomal protein l28 HVX99_16150 ENOG4105D8A 3-Deoxy-D-manno-octulosonic-acid transferase HVX99_16155 ENOG4105DKP glycosyl transferase, family 9 HVX99_16160 ENOG4107RJ7 Glycosyl transferase (Group 1 HVX99_16165 ENOG4107543 (lipo)polysaccharide HVX99_16170 ENOG4106AH0 Glycosyl Transferase HVX99_16175 ENOG4108PDR lipopolysaccharide core biosynthesis protein HVX99_16180 ENOG4105X1N Glycosyl transferase family 8 HVX99_16185 ENOG4107XB0 Lipopolysaccharide 1,2-N-acetylglucosaminetransferase HVX99_16190 ENOG4108FRV O-antigen ligase HVX99_16195 ENOG4105D16 lipopolysaccharide heptosyltransferase i HVX99_16200 ENOG4105XA0 heptosyltransferase ii HVX99_16210 ENOG4108SEH involved in lipopolysaccharide biosynthesis HVX99_16215 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) HVX99_16225 ENOG4105K64 Glycosyl transferase, family 2 HVX99_16230 ENOG4105PXI polysaccharide deacetylase HVX99_16235 ENOG41063SB peptidase HVX99_16245 ENOG4107YZP Rhodanese domain protein HVX99_16250 ENOG4105VW4 glutaredoxin 3 HVX99_16265 ENOG4105D7W serine acetyltransferase HVX99_16270 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) HVX99_16280 ENOG41073TP transcriptional regulator HVX99_16285 ENOG4105DAA L-lactate HVX99_16290 ENOG4105EUR Domain-Containing protein HVX99_16295 ENOG4108WY4 inner membrane lipoprotein HVX99_16300 ENOG4108YYI Protein of unknown function (DUF2810) HVX99_16310 ENOG4105E61 Mannitol repressor protein HVX99_16320 ENOG4105CTS PTS system mannitol-specific HVX99_16325 ENOG4105FP6 Protein of unknown function (DUF3302) HVX99_16330 ENOG4105EFX secretion protein, HlyD family HVX99_16355 ENOG4105NUP lyase containing HEAT-repeat HVX99_16365 ENOG4105CNA YD repeat protein HVX99_16370 ENOG4108U78 Glutathione S-transferase HVX99_16380 ENOG4105EM7 Selenocysteine-specific translation elongation factor HVX99_16385 ENOG4105C0A alcohol dehydrogenase HVX99_16390 ENOG4105C26 Dehydrogenase HVX99_16400 ENOG4105KK7 inner membrane protein YiaW HVX99_16405 ENOG4105EFX secretion protein, HlyD family HVX99_16410 ENOG4108Q2M Transcriptional regulator HVX99_16415 ENOG4105GNX MltA-interacting MipA family protein HVX99_16425 ENOG4105CT4 transporter HVX99_16435 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase HVX99_16440 ENOG41064BZ L-xylulose 5-phosphate 3-epimerase HVX99_16445 ENOG4105H6Q decarboxylase HVX99_16450 ENOG4105CMG Carbohydrate kinase HVX99_16455 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit HVX99_16460 ENOG4105CG6 trap dicarboxylate transporter dctm subunit HVX99_16465 ENOG4105XDZ Tripartite ATP-independent periplasmic transporter HVX99_16470 ENOG4108R66 Conserved Protein HVX99_16480 ENOG4105J4Q Transcriptional regulator HVX99_16485 ENOG4108XIB electron transport protein ysaA HVX99_16495 ENOG4105JKW Valine--pyruvate aminotransferase HVX99_16500 ENOG4107T9C Alpha amylase catalytic region HVX99_16505 ENOG4108UR8 BAX protein HVX99_16510 ENOG4105T16 Transcriptional regulator (AraC family) HVX99_16515 ENOG4108HWW ABC transporter HVX99_16520 ENOG4105C2J ABC transporter HVX99_16525 ENOG4105DFW ABC transporter HVX99_16535 ENOG4105CMG Carbohydrate kinase HVX99_16540 ENOG410688U Inner membrane protein yiaB HVX99_16545 ENOG4108Z12 YiaAB two helix domain-containing protein HVX99_16550 ENOG4105MEV Acyl-transferase HVX99_16570 ENOG41060TC Hok gef cell toxic protein HVX99_16580 ENOG4105MVF Transcriptional regulator HVX99_16585 ENOG4106JH6 (LipO)protein HVX99_16595 ENOG4108ZG0 Ompa motb domain protein HVX99_16600 ENOG4107QY8 reductase HVX99_16605 ENOG4105HNP -acetyltransferase HVX99_16610 ENOG4108R3E Dna-3-methyladenine glycosylase i HVX99_16615 ENOG4105EAX Putative lipase HVX99_16620 ENOG4105FCD Major Facilitator HVX99_16625 ENOG4105DIJ Phosphoethanolamine transferase HVX99_16640 ENOG4105DEF Extracellular solute-binding protein, family 5 HVX99_16645 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HVX99_16650 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HVX99_16655 ENOG4105C3U ABC transporter HVX99_16660 ENOG4108JQ7 (ABC) transporter HVX99_16665 ENOG4105C44 Serine transporter HVX99_16685 ENOG4105D1V cellulose synthase operon protein YhjU HVX99_16690 ENOG4105WQA Cellulose biosynthesis protein BcsF HVX99_16695 ENOG4105U74 cellulose biosynthesis protein BcsE HVX99_16700 ENOG410661M cytoplasmic protein HVX99_16710 ENOG4107QZ7 Cellulose synthase catalytic subunit HVX99_16715 ENOG4107EEX Cellulose synthase regulator protein HVX99_16720 ENOG4105K2Z endo-1,4-d-glucanase (EC 3.2.1.4) HVX99_16725 ENOG4105EJG cellulose synthase HVX99_16730 ENOG4105BZU Histidine kinase HVX99_16740 ENOG4105CS0 peptidase HVX99_16750 ENOG4105CMB EAL domain-containing protein HVX99_16755 ENOG41066T0 asmA family HVX99_16760 ENOG4105CSH Transporter HVX99_16765 ENOG4107H3J ribonuclease HVX99_16770 ENOG4105CBN LysR family transcriptional regulator HVX99_16775 ENOG4106S2D Transcriptional regulator HVX99_16785 ENOG4105CA0 peroxidase HVX99_16790 ENOG4105CVK Glutamate decarboxylase HVX99_16795 ENOG4108NKV transcriptional regulator HVX99_16805 ENOG4105BZS acriflavin resistance protein HVX99_16810 ENOG4105C1P efflux transporter, rnd family, mfp subunit HVX99_16820 ENOG4106WJ0 Regulates the expression of several genes involved in acid resistance. Required for the expression of gadA and gadBC, among others, regardless of media or growth conditions. Binds directly to the 20 bp GAD box found in the control regions of both loci HVX99_16825 ENOG4108YK4 Acid-resistance membrane protein HVX99_16830 ENOG41060V2 Acid-resistance protein HVX99_16835 ENOG4105XXV Acid-resistance protein HVX99_16840 ENOG4105KT7 mgtC SapB transporter HVX99_16850 ENOG4105Y4Z Outer Membrane Lipoprotein HVX99_16870 ENOG4105K89 arsenate reductase HVX99_16875 ENOG4107R5R arsenical pump membrane protein HVX99_16880 ENOG4105KBH arsR family transcriptional regulator HVX99_16895 ENOG4105DC8 reductase HVX99_16900 ENOG4105D6S protein involved in catabolism of external DNA HVX99_16905 ENOG4105DGW oligopeptidase A HVX99_16915 ENOG4105DUX Transporter HVX99_16930 ENOG4105CJ3 phosphate transporter HVX99_16935 ENOG4105CBX hi0933 family HVX99_16940 ENOG4107UNS conserved inner membrane protein HVX99_16955 ENOG4105D0S secretion protein (HlyD HVX99_16960 ENOG4105CJ1 ABC, transporter HVX99_16965 ENOG4105CMI transporter HVX99_16990 ENOG4106665 Part of the ABC transporter complex NikABCDE involved in nickel import. Responsible for energy coupling to the transport system (By similarity) HVX99_16995 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HVX99_17000 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HVX99_17005 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein HVX99_17010 ENOG4107YAK holo-(acyl carrier protein) synthase 2 HVX99_17015 ENOG4105DSF transport protein HVX99_17020 ENOG4105F9N Major Facilitator Superfamily HVX99_17025 ENOG4108W1V Lipoprotein HVX99_17030 ENOG4105EX9 Membrane HVX99_17045 ENOG4107FS9 Membrane HVX99_17055 ENOG4105MG3 Membrane HVX99_17060 ENOG4106H78 methyltransferase HVX99_17065 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) HVX99_17070 ENOG4105CAK Cell division ATP-binding protein ftsE HVX99_17075 ENOG4105CRP Part of the ABC transporter FtsEX involved in HVX99_17080 ENOG4105DEK Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HVX99_17085 ENOG4105CP9 extracellular ligand-binding receptor HVX99_17090 ENOG4105U59 -acetyltransferase HVX99_17095 ENOG4105CP9 extracellular ligand-binding receptor HVX99_17100 ENOG4105C32 Amino acid ABC transporter (Permease) HVX99_17105 ENOG4105CF8 branched-chain amino acid ABC transporter, permease HVX99_17110 ENOG4105C0Z ABC transporter HVX99_17115 ENOG4108IV0 ABC, transporter HVX99_17120 ENOG4105BZ7 extracellular solute-binding protein family 1 HVX99_17125 ENOG4105E4X binding-protein-dependent transport systems inner membrane Component HVX99_17130 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component HVX99_17135 ENOG4108IJ9 (ABC) transporter HVX99_17140 ENOG4107T6V glycerophosphoryl diester phosphodiesterase HVX99_17145 ENOG4105WC8 Conserved Protein HVX99_17150 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) HVX99_17155 ENOG4106FA4 HVX99_17170 ENOG4105GMB type VI secretion system effector, hcp1 family HVX99_17175 ENOG4105WCN acetyltransferase HVX99_17180 ENOG4105D9R oxidoreductase HVX99_17185 ENOG4105C2I pirin domain protein HVX99_17190 ENOG4105DIQ Transcriptional regulator HVX99_17195 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family HVX99_17200 ENOG4105C6Z Gluconate HVX99_17215 ENOG41076UM multiple antibiotic resistance (MarC)-related protein HVX99_17220 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) HVX99_17230 ENOG4108IUM Glycogen debranching enzyme HVX99_17245 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) HVX99_17270 ENOG4105C6V Glycerol-3-phosphate dehydrogenase HVX99_17285 ENOG4105E98 transcriptional regulator DeoR family HVX99_17290 ENOG4105CYB regulatoR HVX99_17295 ENOG4105E0Y RtcB Protein HVX99_17310 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) HVX99_17315 ENOG4107RTM 4-alpha-glucanotransferase (EC 2.4.1.25) HVX99_17320 ENOG4105C6Z Gluconate HVX99_17330 ENOG4105MJ2 Competence protein HVX99_17350 ENOG4105CE1 Ferrous iron transport protein b HVX99_17355 ENOG4105XFK Ferrous iron transport protein A HVX99_17360 ENOG4105BZM domain protein HVX99_17365 ENOG4108RRZ Transcription elongation factor GreB HVX99_17375 ENOG4105E0F Histidine kinase HVX99_17385 ENOG4108MAJ Membrane HVX99_17395 ENOG4105VEJ Heat shock protein HVX99_17400 ENOG4107Y3D HAD-superfamily hydrolase subfamily IA variant 3 HVX99_17405 ENOG4105DQY intracellular growth attenuator HVX99_17410 ENOG4107RK2 ADP-ribose diphosphatase NudE HVX99_17415 ENOG4108JQC penicillin-binding protein 1A HVX99_17420 ENOG4108U1Q Pilus assembly protein HVX99_17425 ENOG41065NF Fimbrial assembly family protein HVX99_17430 ENOG4105XPX DNA utilization protein HofO HVX99_17435 ENOG4105ITY Required for the use of extracellular DNA as a nutrient HVX99_17440 ENOG4105E4G Type IV pilus HVX99_17455 ENOG4105EGB membrane protein DamX HVX99_17460 ENOG4105DFE Dna adenine methylase HVX99_17465 ENOG4105DJV ribulose-phosphate 3-epimerase HVX99_17470 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) HVX99_17475 ENOG4105C31 Tryptophanyl-tRNA synthetase HVX99_17480 ENOG4108M21 HVX99_17485 ENOG4105RMW regulation of transcription, DNA-dependent HVX99_17490 ENOG4108626 Racemase HVX99_17495 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) HVX99_17500 ENOG41080QX K07048 phosphotriesterase-related protein HVX99_17505 ENOG4105MUZ Protein of unknown function DUF2620 HVX99_17510 ENOG4106M0N transport system permease protein HVX99_17515 ENOG4106PKC pyridoxal phosphate binding HVX99_17520 ENOG4105FDP GntR family transcriptional regulator HVX99_17525 ENOG4108KPW sugar kinase HVX99_17530 ENOG4107Y0V Not clear, may be involved in an isomerization step HVX99_17535 ENOG4107R1S catalyzes the conversion of fructoselysine 6-phosphate to glucose 6-phosphate and lysine HVX99_17540 ENOG4107QHQ amino acid HVX99_17545 ENOG4105VYH HVX99_17555 ENOG4107V9H nitrite transporter HVX99_17560 ENOG4105WZK nitrite reductase NADPH small subunit HVX99_17565 ENOG4107QZF nitrite reductase NADPH large subunit HVX99_17575 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) HVX99_17585 ENOG4105MZU cell filamentation protein HVX99_17590 ENOG4105DDQ anthranilate synthase HVX99_17595 ENOG4105C8Y Acetylornithine aminotransferase HVX99_17600 ENOG410613R integral membrane protein, YccS YhfK family HVX99_17610 ENOG4108UKZ OsmC family HVX99_17615 ENOG4105CJE phosphoribulokinase (EC 2.7.1.19) HVX99_17625 ENOG4105DNZ Alpha Beta Hydrolase HVX99_17630 ENOG4105C5H ABC transporter HVX99_17645 ENOG4105VKU nucleicacid-binding protein HVX99_17650 ENOG4108YZY peptidylprolyl cis-trans isomerase HVX99_17660 ENOG4108V1T peptidylprolyl cis-trans isomerase HVX99_17665 ENOG4105WWK YheO domain protein HVX99_17705 ENOG4105W53 bacterioferritin-associated ferredoxin HVX99_17710 ENOG4108UQY Iron-storage protein HVX99_17735 ENOG41080KG One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) HVX99_17780 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) HVX99_17825 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) HVX99_17830 ENOG41067V7 50S ribosomal protein L36 HVX99_17860 ENOG4105VTS DnaJ-like, subfamily C HVX99_17865 ENOG4105W1Y Transcriptional regulator HVX99_17870 ENOG4105VCN Rescues the ribosomes stalled at the 3' end of non-stop mRNAs. May induce hydrolysis of the ribosome-bound peptidyl-tRNA. This activity is crucial when the stalled ribosome can not be rescued by the SsrA(tmRNA)-SmpB quality control system HVX99_17880 ENOG4105C1A potassium transporter peripheral membrane HVX99_17900 ENOG4105C79 DNA protecting protein DprA HVX99_17910 ENOG4108WI1 Dna topoisomerase HVX99_17925 ENOG4105SG3 Protein of unknown function (DUF1488) HVX99_17930 ENOG4108Z0R Transferase HVX99_17970 ENOG4105CDA abc transporter atp-binding protein HVX99_17975 ENOG4105DRP amino acid AbC transporter HVX99_17980 ENOG4105EZ7 amino acid ABC transporter HVX99_17990 ENOG4105XCM membrane LIPOPROTEIN HVX99_17995 ENOG4105BZS acriflavin resistance protein HVX99_18000 ENOG4105C1P efflux transporter, rnd family, mfp subunit HVX99_18005 ENOG4108XG4 DNA-binding transcriptional regulator HVX99_18010 ENOG41061ME transport protein HVX99_18015 ENOG4105CEC DNA methylase N-4 N-6 HVX99_18025 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) HVX99_18035 ENOG4108IA2 Sodium pantothenate symporter HVX99_18040 ENOG4105RG0 Membrane HVX99_18045 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase HVX99_18050 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein HVX99_18060 ENOG4105D3Z quinone oxidoreductase, yhdh yhfp family HVX99_18065 ENOG41062P1 Diguanylate cyclase phosphodiesterase HVX99_18075 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) HVX99_18080 ENOG4105VQ7 Rod shape-determining protein MreD HVX99_18090 ENOG4105C03 ribonuclease HVX99_18095 ENOG4105QD6 exported protein HVX99_18100 ENOG4105D1U peptidase U62 modulator of DNA gyrase HVX99_18105 ENOG4105CR8 Transcriptional regulator HVX99_18110 ENOG4105ZQC membrane protein AaeX HVX99_18125 ENOG4105UNR (Barnase) inhibitor HVX99_18130 ENOG4105RID UPF0379 protein yhcN HVX99_18145 ENOG4105C0H protease HVX99_18150 ENOG4105C0H protease HVX99_18155 ENOG4108W2Q Cytochrome d ubiquinol oxidase subunit III HVX99_18160 ENOG4105D6Z AFG1 family ATPase HVX99_18175 ENOG4107MKT Stringent starvation protein a HVX99_18180 ENOG4105KB2 stringent starvation protein b HVX99_18185 ENOG4105CEE C4-dicarboxylate transporter HVX99_18190 ENOG4108QBF Transcriptional regulator HVX99_18200 ENOG4105JHE Major Facilitator Superfamily HVX99_18215 ENOG4108R66 Conserved Protein HVX99_18220 ENOG4105DFS Conserved Protein HVX99_18225 ENOG4105BZ8 glutamate synthase HVX99_18230 ENOG4105CBC glutamate synthase HVX99_18235 ENOG4105N5T Radical SAM Protein HVX99_18240 ENOG4105BZU Histidine kinase HVX99_18245 ENOG4108556 Isoprenoid biosynthesis protein with amidotransferase-like domain HVX99_18255 ENOG4108NIH transferase activity, transferring phosphorus-containing groups HVX99_18260 ENOG41080Z8 PHOSPHOCARRIER protein HVX99_18270 ENOG4107RM2 PTS IIA-like nitrogen-regulatory protein PtsN HVX99_18275 ENOG41080QH sigma 54 modulation protein ribosomal protein S30EA HVX99_18280 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HVX99_18285 ENOG4108IUZ ABC transporter HVX99_18290 ENOG4105WI0 lipopolysaccharide transport periplasmic protein lptA HVX99_18295 ENOG4108P1K Required for the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane (By similarity) HVX99_18300 ENOG4108Z4R 3-deoxy-d-manno-octulosonate 8-phosphate phosphatase HVX99_18305 ENOG4105C2X Arabinose 5-phosphate isomerase HVX99_18310 ENOG4105FEU K -dependent Na -Ca exchanger HVX99_18315 ENOG4105DHJ ABC, transporter HVX99_18320 ENOG4105CY3 ABC transporter, permease HVX99_18325 ENOG4107PE3 Mammalian cell entry related domain protein HVX99_18330 ENOG4105E3I toluene tolerance HVX99_18335 ENOG4105UE2 Part of the ABC transporter complex MlaFEDB that actively prevents phospholipid accumulation at the cell surface. Probably maintains lipid asymmetry in the outer membrane by retrograde trafficking of phospholipids from the outer membrane to the inner membrane HVX99_18340 ENOG4105VFK BolA family HVX99_18350 ENOG4105HVQ Regulatory factor of maltose metabolism HVX99_18355 ENOG4105EAH synthase HVX99_18370 ENOG4105QYV Membrane HVX99_18380 ENOG4106HRJ d-alanyl-d-alanine carboxypeptidase HVX99_18385 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) HVX99_18390 ENOG4105HBR Rna-binding protein HVX99_18400 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) HVX99_18405 ENOG4105EEI dihydropteroate synthase HVX99_18415 ENOG4105NTZ Preprotein translocase subunit SecG HVX99_18425 ENOG4105DIJ Phosphoethanolamine transferase HVX99_18445 ENOG4105CHV Transcription elongation factor NusA HVX99_18485 ENOG4105C1J atp-dependent rna helicase HVX99_18490 ENOG4105CIC tryptophan-specific transport protein HVX99_18495 ENOG4105DEN Luciferase family HVX99_18515 ENOG4108YYD acetyltransferase HVX99_18530 ENOG4107R7Y intracellular protease Pfpi family HVX99_18535 ENOG4105K4T epimerase HVX99_18540 ENOG4107S21 permease HVX99_18545 ENOG4105W4M Transport-associated protein HVX99_18555 ENOG41082RQ UPF0102 protein HVX99_18560 ENOG4105E1C Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1A (PBP1a) (By similarity) HVX99_18565 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) HVX99_18570 ENOG4105I74 Fimbrial protein HVX99_18575 ENOG4105CW0 outer membrane usher protein HVX99_18580 ENOG4108VCD Chaperone HVX99_18585 ENOG4105Q10 Fimbrial-like protein HVX99_18590 ENOG4106HBN Galactosamine-6-phosphate isomerase HVX99_18595 ENOG4105F3R pts system mannose fructose sorbose family iid HVX99_18600 ENOG4105ETZ PTS System HVX99_18605 ENOG4108UZY PTS System HVX99_18615 ENOG4105E70 isomerase HVX99_18620 ENOG4105CE4 GlcNAc 6-P deacetylase HVX99_18625 ENOG4108YTN IIa component HVX99_18630 ENOG4105F3R pts system mannose fructose sorbose family iid HVX99_18640 ENOG4108RG5 PTS system N-acetylgalactosamine-specific transporter subunit IIB HVX99_18650 ENOG4105E98 transcriptional regulator DeoR family HVX99_18655 ENOG4108R8Z these effects are overcome by concomitant expression of antitoxin SohA (PrlF). Massive overexpression is toxic. Unlike most other characterized TA systems degrades rRNA, and co-folding of the proteins is necessary in vitro for inhibition of the RNase activity. It is not known if it has any sequence-specificity. Acts as a transcription factor. The YhaV PrlF complex binds the prlF-yhaV operon, probably negatively regulating its expression HVX99_18660 ENOG4105ZEG Suppressor protein HVX99_18665 ENOG4105CTX dehydratase HVX99_18670 ENOG4105DJB Major Facilitator Superfamily HVX99_18680 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase HVX99_18685 ENOG4105BZW Glycerate kinase HVX99_18710 ENOG410811B TRANSCRIPTIONal HVX99_18715 ENOG4105C7B Threonine dehydratase HVX99_18725 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) HVX99_18730 ENOG4105C6N Formate acetyltransferase HVX99_18735 ENOG4105KME endoribonuclease L-psp HVX99_18740 ENOG4105EJQ L-serine dehydratase HVX99_18745 ENOG4105C44 Serine transporter HVX99_18755 ENOG4106D80 Uncharacterized protein YhaL HVX99_18760 ENOG4108CNN domain protein HVX99_18765 ENOG4105CWB LysR family transcriptional Regulator HVX99_18770 ENOG4105KAF membrAne HVX99_18775 ENOG4105KAF membrAne HVX99_18780 ENOG4105CHF Glutathione S-transferase HVX99_18785 ENOG4108VBZ doxx family HVX99_18790 ENOG4105YJD HVX99_18795 ENOG41090KG Inner membrane protein YqjE HVX99_18800 ENOG4105NE1 Conserved Protein HVX99_18805 ENOG4105WAY exported protein HVX99_18810 ENOG4105IYR Modulates the activity of the EnvZ OmpR two-component regulatory system, probably by directly modulating EnvZ enzymatic activity and increasing stability of phosphorylated OmpR (By similarity) HVX99_18815 ENOG4106W5V Membrane HVX99_18820 ENOG4107YCY Transcriptional regulator HVX99_18845 ENOG4105DPW Major facilitator superfamily MFS_1 HVX99_18855 ENOG4105CTX dehydratase HVX99_18860 ENOG4105P66 Membrane HVX99_18865 ENOG4107QV7 Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system) (By similarity) HVX99_18870 ENOG4105DU1 integral membrane protein, terc HVX99_18875 ENOG4105EE0 oxidoreductase HVX99_18880 ENOG4108UB4 uncharacterized protein ygjQ HVX99_18885 ENOG4108VKG metal-dependent hydrolase HVX99_18900 ENOG4108Z3N Transcriptional regulator HVX99_18905 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HVX99_18910 ENOG4107WCA isomerase HVX99_18915 ENOG4107W6W Conserved Protein HVX99_18920 ENOG4105E5D amino acid HVX99_18925 ENOG4105FK9 beta-D-galactosidase beta subunit HVX99_18930 ENOG4105CNT hydrolase family 2 HVX99_18935 ENOG4105CQ4 Transcriptional regulator HVX99_18940 ENOG4108Y51 tRNA-binding protein HVX99_18950 ENOG4107RHT methyl-accepting chemotaxis sensory transducer with Pas Pac sensor HVX99_18955 ENOG4105NTW Transcriptional regulator HVX99_18960 ENOG4105Q26 Siderophore-interacting protein HVX99_18975 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HVX99_18980 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) HVX99_18995 ENOG4107QPK )-transporter HVX99_19000 ENOG4107GFK fumarate HVX99_19005 ENOG4106DSS Tartrate dehydratase subunit alpha HVX99_19010 ENOG4105EJC lysr family transcriptional regulator HVX99_19020 ENOG4107ZVW dihydroneopterin aldolase HVX99_19035 ENOG4106MWK domain protein HVX99_19040 ENOG4105I7R Adenylate cyclase HVX99_19065 ENOG4107S78 Band 7 protein HVX99_19070 ENOG4105PV3 Inner membrane protein yqiJ HVX99_19080 ENOG4108MY7 Fimbrial HVX99_19085 ENOG4108TTM chaperone HVX99_19095 ENOG4105H8W Fimbrial protein HVX99_19100 ENOG4105W0Z cytoplasmic protein HVX99_19120 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b HVX99_19125 ENOG4106032 Glutathionylspermidine synthase HVX99_19135 ENOG4105DFG type I secretion outer membrane protein HVX99_19140 ENOG41087AY ADP-Ribose pyrophosphatase HVX99_19145 ENOG4108SX3 cytoplasmic protein HVX99_19150 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) HVX99_19155 ENOG4105IPS esterase HVX99_19160 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HVX99_19165 ENOG4105VRH Antibiotic biosynthesis monooxygenase HVX99_19170 ENOG4105NF4 modulator of drug activity HVX99_19175 ENOG4107DEU Inner membrane protein YgiZ HVX99_19180 ENOG4105DHQ Histidine kinase HVX99_19185 ENOG4105XJC Two component transcriptional regulator (Winged helix family HVX99_19190 ENOG4105H4F exported protein HVX99_19195 ENOG4105F4I Transcriptional regulator HVX99_19200 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HVX99_19205 ENOG4107S7E 1-acyl-sn-glycerol-3-phosphate acyltransferase HVX99_19210 ENOG4107TZ2 Cell division protein that is required for growth during stress conditions. May be involved in protecting or stabilizing the divisomal assembly under conditions of stress (By similarity) HVX99_19215 ENOG4105CCT upf0313 protein HVX99_19225 ENOG4105ZKC Conserved Protein HVX99_19230 ENOG4105CV8 reductase HVX99_19235 ENOG4108I6A alcohol dehydrogenase HVX99_19240 ENOG4105CF7 AraC family transcriptional regulator HVX99_19245 ENOG4108K81 inner membrane protein YghB HVX99_19250 ENOG4105C28 cystathionine HVX99_19255 ENOG4105CWK Biopolymer transport protein, ExbB HVX99_19260 ENOG4108ZZF transport protein (ExbD) HVX99_19265 ENOG4105CYX Short-chain dehydrogenase reductase Sdr HVX99_19275 ENOG4105CPC Aldo Keto reductase HVX99_19285 ENOG410900S Protein of unknown function (DUF2623) HVX99_19290 ENOG4105E3S small subunit HVX99_19295 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein HVX99_19300 ENOG4105CJ5 hydrogenase 2 b cytochrome subunit HVX99_19305 ENOG4105DPX Hydrogenase, large subunit HVX99_19310 ENOG4108USZ hydrogenase HVX99_19315 ENOG4108WGS hydrogenase 2-specific chaperone HVX99_19320 ENOG4105WMM Probably plays a role in a hydrogenase nickel cofactor insertion step (By similarity) HVX99_19325 ENOG41082MF Hydrogenase assembly chaperone hypC hupF HVX99_19335 ENOG4105CYM Glutathione S-transferase HVX99_19340 ENOG4106032 Glutathionylspermidine synthase HVX99_19345 ENOG4105CJ3 phosphate transporter HVX99_19350 ENOG4108GH0 ATP-binding protein yghT HVX99_19355 ENOG4108NDC ATP-binding protein yghS HVX99_19360 ENOG4106FPV ATP-binding protein YghR HVX99_19365 ENOG4108S55 polysaccharide biosynthesis protein HVX99_19375 ENOG4108UUE Transcriptional regulator HVX99_19380 ENOG4108M8S permease YjgP YjgQ family protein HVX99_19390 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) HVX99_19395 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) HVX99_19405 ENOG4107RCI amp-dependent synthetase and ligase HVX99_19415 ENOG4108KWP DNA-binding transcriptional regulator GlcC HVX99_19420 ENOG4105CQB FAD linked oxidase domain protein HVX99_19425 ENOG4105EU8 FAD linked oxidase domain protein HVX99_19430 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) HVX99_19435 ENOG4108ZJF Glcg protein HVX99_19440 ENOG4107QP3 malate synthase g HVX99_19445 ENOG4105DAA L-lactate HVX99_19475 ENOG4107QHF type ii secretion system protein e HVX99_19480 ENOG4105D7Q type ii secretion system HVX99_19485 ENOG4108VAU general secretion pathway protein G HVX99_19495 ENOG4105X5Z General secretion pathway protein I HVX99_19515 ENOG4105U1E general secretion pathway protein M HVX99_19525 ENOG4108UQV Membrane HVX99_19530 ENOG4105CXN decarboxylase HVX99_19535 ENOG4105EAA nucleoside HVX99_19550 ENOG4105CEN a g-specific adenine glycosylase HVX99_19560 ENOG41090ED Protein with unknown function (DUF469) HVX99_19565 ENOG4105K33 Periplasmic Protein HVX99_19570 ENOG4105HDK L-asparaginase HVX99_19575 ENOG4106MH3 alpha helix chain HVX99_19580 ENOG4105CSA Coproporphyrinogen iii oxidase HVX99_19585 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) HVX99_19595 ENOG4108VIA integral membrane protein HVX99_19600 ENOG4105DFA alanine racemase domain protein HVX99_19605 ENOG4105CZX twitching motility protein HVX99_19620 ENOG4105D7Z glutathione synthase HVX99_19625 ENOG4105QF0 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) HVX99_19630 ENOG4105RWS endonuclease I HVX99_19640 ENOG4107QNK )-transporter HVX99_19660 ENOG4105DP5 Catalyzes the biosynthesis of agmatine from arginine (By similarity) HVX99_19675 ENOG4108K0D peptidase, M48 HVX99_19680 ENOG4105CV1 Transketolase (EC 2.2.1.1) HVX99_19685 ENOG4108X7Y Mannitol-specific cryptic phosphotransferase enzyme iia HVX99_19690 ENOG4105CTS PTS system mannitol-specific HVX99_19695 ENOG4105DXH Alcohol dehydrogenase zinc-binding domain protein HVX99_19700 ENOG4108Q8A Fructose-1,6-bisphosphatase HVX99_19705 ENOG4108R4K DNA-binding, transcriptional regulator HVX99_19710 ENOG4107Z1W Fructose transport system kinase HVX99_19715 ENOG4108JJB ABC transporter HVX99_19720 ENOG4108JJB ABC transporter HVX99_19750 ENOG4105D2N Aldolase HVX99_19755 ENOG4105D64 Mechanosensitive ion channel HVX99_19760 ENOG4108ZUB Lysine exporter protein (Lyse ygga) HVX99_19765 ENOG4105MPN Membrane HVX99_19770 ENOG4105DEQ transcriptional regulator HVX99_19775 ENOG4105CYC Transferase HVX99_19780 ENOG4108M7F enoyl-CoA hydratase isomerase HVX99_19785 ENOG4105DJT lAO AO transport system ATPase HVX99_19790 ENOG4105D5P Methylmalonyl-coA mutase HVX99_19810 ENOG4108JQ1 Dehydrogenase HVX99_19825 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase HVX99_19845 ENOG4107RAQ aminopeptidase HVX99_19850 ENOG4105D0A hydroxylase HVX99_19855 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family HVX99_19880 ENOG4105CYX Short-chain dehydrogenase reductase Sdr HVX99_19885 ENOG4105CS2 ec 3.2.1.21 HVX99_19895 ENOG4108UT2 hemolysin iii HVX99_19905 ENOG4105Y75 tpr repeat protein HVX99_19910 ENOG4108YDB Toxic component of a toxin-antitoxin (TA) module. Overexpression leads to growth arrest after 5 hours, with initial elongation of cells, followed by swelling. The toxic effects are abrogated by coexpression with antitoxin CptB. Interacts with cytoskeletal proteins FtsZ and MreB HVX99_19915 ENOG41071R3 Low-potential electron donor to a number of redox enzymes (By similarity) HVX99_19920 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HVX99_19925 ENOG4105T95 Thiol disulfide interChange protein HVX99_19930 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) HVX99_19960 ENOG4105C2W permease HVX99_19965 ENOG4105BZ8 glutamate synthase HVX99_19970 ENOG4108R8B oxidoreductase Fe-S subunit HVX99_19975 ENOG4105C7N Xanthine uracil vitamin C permease HVX99_19980 ENOG4107QUY Guanine deaminase HVX99_19985 ENOG4105C2W permease HVX99_19990 ENOG4105C7W Xanthine dehydrogenase HVX99_19995 ENOG410873Y FAD binding domain in molybdopterin dehydrogenase HVX99_20000 ENOG4107UUR Chlorohydrolase aminohydrolase HVX99_20005 ENOG4105BZ8 glutamate synthase HVX99_20010 ENOG4105MFX 4-diphosphocytidyl-2c-methyl-d-erythritol synthase HVX99_20015 ENOG4105MJ6 selenium-dependent hydroxylase accessory protein YqeC HVX99_20020 ENOG4107P0T Selenium-dependent molybdenum hydroxylase system protein, YqeB family HVX99_20025 ENOG4105C5B carbamate kinase HVX99_20035 ENOG4107S4Y M20 DapE family protein YgeY HVX99_20040 ENOG4107RCH Diaminopropionate ammonia-lyase HVX99_20045 ENOG4105IW6 Carbamoyltransferase HVX99_20050 ENOG4108JUB Transcriptional regulator HVX99_20055 ENOG4108UTP (2Fe-2S)-binding domain protein HVX99_20060 ENOG4108HR6 Dehydrogenase HVX99_20065 ENOG4105C7W Xanthine dehydrogenase HVX99_20070 ENOG4108K5P (LipO)protein HVX99_20080 ENOG4108T88 HVX99_20090 ENOG41075IY surface presentation of antigens protein SpaP HVX99_20095 ENOG4105U07 type iii secretion HVX99_20100 ENOG4108TN6 type iii secretion HVX99_20105 ENOG4108M6W surface presentation of antigens protein SpaS HVX99_20110 ENOG4108M6W surface presentation of antigens protein SpaS HVX99_20170 ENOG4108YAB Invasion protein HVX99_20195 ENOG4105FV3 HVX99_20200 ENOG4108TC1 Transcriptional regulator HVX99_20205 ENOG4105ISV protein with bipartite regulator domain HVX99_20210 ENOG4108MHD transport protein HVX99_20215 ENOG4105CHU acetyl-coa acetyltransferase HVX99_20225 ENOG4105CHR reductase HVX99_20230 ENOG4107QNK )-transporter HVX99_20240 ENOG4105RQF LysR family Transcriptional regulator HVX99_20250 ENOG41060NJ transcriptional regulator HVX99_20260 ENOG4107S74 Lysophospholipid transporter LplT HVX99_20265 ENOG4105CPC Aldo Keto reductase HVX99_20270 ENOG4105SUV lipoprotein YgdR HVX99_20275 ENOG4105EE5 Membrane protein terC HVX99_20290 ENOG4108HRM phosphoenolpyruvate--protein phosphotransferase HVX99_20305 ENOG4105IPU prepilin peptidase dependent protein A HVX99_20310 ENOG4105JCS prepilin peptidase dependent protein HVX99_20315 ENOG4105SEN Protein of unknown function (DUF2509) HVX99_20320 ENOG4105RVB Prepilin peptidase dependent protein c HVX99_20325 ENOG4105DSY exodeoxyribonuclease V, gamma HVX99_20330 ENOG4107QXK peptidase HVX99_20335 ENOG4107QKA exodeoxyribonuclease V beta HVX99_20340 ENOG4107QYX exodeoxyribonuclease v alpha HVX99_20345 ENOG4108EKC n-acetylglutamate synthase HVX99_20350 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase HVX99_20355 ENOG4105CID antiterminator HVX99_20360 ENOG4105CI1 PTS System HVX99_20365 ENOG4105C87 Aminotransferase class I and II HVX99_20370 ENOG4105C2X Arabinose 5-phosphate isomerase HVX99_20395 ENOG4105CA3 membrane-bound lytic murein transglycosylase HVX99_20400 ENOG4105CUZ uba thif-type nad fad binding protein HVX99_20405 ENOG4105P9C Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity) HVX99_20410 ENOG4105C9B Cysteine desulfurase HVX99_20415 ENOG4105M5B (LipO)protein HVX99_20420 ENOG4105ETT transcriptional Regulator, LysR family HVX99_20425 ENOG4105M08 Membrane HVX99_20435 ENOG4107EDW L-fucose operon activator HVX99_20445 ENOG4105CMG Carbohydrate kinase HVX99_20455 ENOG4105EDR glucose galactose transporter HVX99_20460 ENOG4107W7X Aldolase HVX99_20465 ENOG4105C0A alcohol dehydrogenase HVX99_20475 ENOG4105EJQ L-serine dehydratase HVX99_20480 ENOG4105C44 Serine transporter HVX99_20485 ENOG4105EWT decarboxylase family HVX99_20500 ENOG4105WP7 tRNA pseudouridine synthase C HVX99_20505 ENOG4105DR9 pseudouridine synthase HVX99_20510 ENOG4105QDK Flavodoxin HVX99_20515 ENOG4105DJB Major Facilitator Superfamily HVX99_20520 ENOG4105EQX glucarate dehydratase HVX99_20525 ENOG4105EQX glucarate dehydratase HVX99_20530 ENOG4105BZU Histidine kinase HVX99_20535 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) HVX99_20540 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) HVX99_20545 ENOG4106A2Z transcriptional regulator antitoxin, MazE HVX99_20550 ENOG4105MZG transcriptional modulator of maze toxin, mazf HVX99_20555 ENOG4105DXN mazG family HVX99_20570 ENOG4105HA9 of methanol dehydrogenase type HVX99_20580 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) HVX99_20585 ENOG4108CWB sugar kinase ygcE HVX99_20590 ENOG4108ITV Inner membrane protein yqcE HVX99_20595 ENOG4105CHR reductase HVX99_20600 ENOG4107R3A FAD linked oxidase domain protein HVX99_20605 ENOG4105C54 Major Facilitator superfamily HVX99_20610 ENOG4106IKH Electron transfer flavoprotein HVX99_20615 ENOG4105YBM electron transfer flavoprotein subunit ygcQ HVX99_20620 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator HVX99_20625 ENOG4105WQV ferredoxin-like protein HVX99_20630 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase HVX99_20635 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase HVX99_20655 ENOG4107635 Hok Gef family protein HVX99_20660 ENOG4105DTT CRISPR-associated helicase, cas3 HVX99_20665 ENOG4105CYR Crispr-associated protein, cse1 family HVX99_20675 ENOG41060M0 Crispr-associated protein, cse4 family HVX99_20680 ENOG4108VWQ crispr-associated protein HVX99_20690 ENOG4105TZK CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. May be involved in the integration of spacer DNA into the CRISPR cassette (By similarity) HVX99_20695 ENOG4105PWE CRISPR-associated protein cas2 HVX99_20700 ENOG4108MXK alkaline phosphatase isozyme conversion HVX99_20720 ENOG4105N0Z inner membrane protein ygbE HVX99_20755 ENOG4108K5P (LipO)protein HVX99_20760 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HVX99_20770 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase HVX99_20775 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) HVX99_20780 ENOG4105KZM cytoplasmic protein HVX99_20785 ENOG4105C6Z Gluconate HVX99_20790 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) HVX99_20795 ENOG4105FB2 class II Aldolase HVX99_20800 ENOG4105G63 Type III effector Hrp-dependent HVX99_20805 ENOG4105ZXK Dehydrogenase HVX99_20810 ENOG4105MVE transcriptional regulator HVX99_20815 ENOG4105MEW serine threonine protein phosphatase HVX99_20830 ENOG4105VXR cytoplasmic protein HVX99_20835 ENOG4108JUA Transcriptional regulator HVX99_20840 ENOG4105C45 hydrogenase expression formation protein (HypE) HVX99_20845 ENOG4105CQS hydrogenase expression formation protein HypD HVX99_20850 ENOG41083WG hydrogenase assembly chaperone HVX99_20855 ENOG4107RSS Hydrogenase accessory protein HypB HVX99_20860 ENOG410816D Probably plays a role in a hydrogenase nickel cofactor insertion step (By similarity) HVX99_20865 ENOG4108VRC Formate hydrogenlyase regulatory protein hycA HVX99_20870 ENOG4108MFN small subunit of hydrogenase-3, iron-sulfur protein (part of formate hydrogenlyase (FHL) complex) HVX99_20875 ENOG4107R30 NADH dehydrogenase HVX99_20880 ENOG4107TDF Formate hydrogenlyase subunit 4 HVX99_20885 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HVX99_20890 ENOG4108RG7 formate hydrogenlyase complex iron-sulfur subunit HVX99_20895 ENOG4105C47 NADH ubiquinone oxidoreductase 20 kda subunit HVX99_20900 ENOG4105I6X formate hydrogenlyase maturation HVX99_20905 ENOG4108MG9 hydrogenase 3 maturation protease HVX99_20915 ENOG4108Z3N Transcriptional regulator HVX99_20920 ENOG4105CS2 ec 3.2.1.21 HVX99_20925 ENOG4105C5Y PTS System HVX99_20930 ENOG4105DDV Transcriptional regulator (LacI family HVX99_20935 ENOG4108RC0 Electron transport protein HVX99_20940 ENOG4105C8H hydrogenase maturation protein Hypf HVX99_20965 ENOG410804X Transcriptional regulator HVX99_20970 ENOG4105J92 DNA-binding transcriptional activator GutM HVX99_20975 ENOG4107QMF Sorbitol-6-phosphate dehydrogenase HVX99_20980 ENOG4105VI0 Pts system, glucitol sorbitol-specific HVX99_20985 ENOG4105DZY Pts system, glucitol sorbitol-specific HVX99_20990 ENOG410787A Pts system, glucitol sorbitol-specific HVX99_20995 ENOG4105CVE Lytic murein transglycosylase HVX99_21000 ENOG4107TH8 cina domain protein HVX99_21020 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) HVX99_21050 ENOG4107VXZ Hydrolase HVX99_21055 ENOG4105W39 Membrane HVX99_21070 ENOG4105C0R drug resistance transporter emrb qaca subfamily HVX99_21075 ENOG4105CW7 secretion protein, HlyD family HVX99_21080 ENOG4105NTK Transcriptional repressor Mpra HVX99_21085 ENOG4105ZED uncharacterized protein ygaH HVX99_21090 ENOG4108UMN azlc family HVX99_21100 ENOG4105GIJ Glycine betaine HVX99_21105 ENOG4108HQS Glycine betaine HVX99_21110 ENOG4108IJ7 Glycine betaine HVX99_21115 ENOG4107R25 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HVX99_21120 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HVX99_21130 ENOG4105WAZ (Glutaredoxin-like protein) NrdH HVX99_21135 ENOG4108ZQZ Bacterial protein of unknown function (DUF883) HVX99_21140 ENOG4108WMJ Protein of unknown function (DUF2002) HVX99_21145 ENOG4108RNS Exports L-alanine (By similarity) HVX99_21150 ENOG4108X73 DNA- binding protein HVX99_21155 ENOG4108V62 Rhodanese domain protein HVX99_21160 ENOG41080HT Transcriptional regulator, arsr family HVX99_21165 ENOG4105VPI YqaE family transport protein HVX99_21170 ENOG4109066 lysm domain bon superfamily protein HVX99_21175 ENOG4108PVQ transcriptional regulator HVX99_21180 ENOG4105C85 amino acid HVX99_21185 ENOG4108JPW Aminotransferase HVX99_21190 ENOG4105C26 Dehydrogenase HVX99_21195 ENOG4105D5U fad dependent oxidoreductase HVX99_21200 ENOG4105EK3 May be involved in the control of utilization of gamma- aminobutyric acid (By similarity) HVX99_21230 ENOG4105DFP Integrase HVX99_21290 ENOG4105DFP Integrase HVX99_21305 ENOG4108Z1B Cyclase dehydrase HVX99_21315 ENOG4105YRI Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) HVX99_21320 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) HVX99_21335 ENOG4108JU6 CBS domain protein HVX99_21340 ENOG4106KVJ cytochrome C assembly protein HVX99_21345 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY HVX99_21370 ENOG41090EK ompa motb domain protein HVX99_21375 ENOG4108KHX Diguanylate cyclase HVX99_21380 ENOG4108WS1 HVX99_21385 ENOG4105QP9 Protein of unknown function (DUF2799) HVX99_21390 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) HVX99_21395 ENOG4105EHE chorismate mutase- prephenate dehydrogenase HVX99_21400 ENOG4105CQC Prephenate dehydratase HVX99_21410 ENOG4108WPH sigma 54 modulation protein ribosomal protein S30EA HVX99_21415 ENOG4106SNF Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane HVX99_21420 ENOG4105C34 Pseudouridine synthase HVX99_21425 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase HVX99_21430 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit HVX99_21455 ENOG4105CSH Transporter HVX99_21460 ENOG4105T42 (LipO)protein HVX99_21465 ENOG4105JIM Phosphatidylserine synthase HVX99_21470 ENOG4105CD5 CoA-binding domain protein HVX99_21475 ENOG4106IUH DTW domain containing protein HVX99_21480 ENOG4105K63 Thioredoxin HVX99_21485 ENOG4105EIB trna rrna methyltransferase HVX99_21505 ENOG41090KR LysR family transcriptional Regulator HVX99_21510 ENOG4105C1J atp-dependent rna helicase HVX99_21520 ENOG4108IYU L-aspartate oxidase HVX99_21530 ENOG4105EMN RNA polymerase sigma factor HVX99_21535 ENOG41069PW sigma-e factor negative regulatory protein HVX99_21540 ENOG4105VQK sigma E regulatory protein, MucB RseB HVX99_21545 ENOG4105WMJ Positive regulator of sigma E, RseC MucC HVX99_21555 ENOG4105C3F Signal peptidase i HVX99_21575 ENOG4105CSZ Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity) HVX99_21590 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding HVX99_21595 ENOG4106G6Q Transcriptional regulator HVX99_21600 ENOG4105HYY HAD superfamily (Subfamily IF) hydrolase, YfhB HVX99_21605 ENOG4108Z6B deaminase HVX99_21615 ENOG4108ETH Formylglycinamide ribotide synthetase HVX99_21620 ENOG4107WP9 Histidine kinase HVX99_21625 ENOG4108SKK alpha helix protein HVX99_21630 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family HVX99_21640 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) HVX99_21650 ENOG4108NZE NAGC-like transcriptional regulator HVX99_21655 ENOG4107HQ7 repeat protein HVX99_21660 ENOG4105FCA ABC transporter periplasmic-binding protein YphF HVX99_21665 ENOG4108F37 ATP-binding component of a transport system HVX99_21670 ENOG4105CNN ABC, transporter HVX99_21675 ENOG4105CPQ Dehydrogenase HVX99_21680 ENOG4108ZKT aldose 1-epimerase HVX99_21685 ENOG4108SB3 DoxX Family HVX99_21710 ENOG4105FUY alpha subunit HVX99_21715 ENOG4108W5M transcriptional regulator HVX99_21720 ENOG4105D8G Major Facilitator superfamily HVX99_21725 ENOG4108MN2 Stationary phase inducible protein CsiE HVX99_21730 ENOG4107XM9 (LipO)protein HVX99_21735 ENOG4105ECY inositol monophosphatase HVX99_21755 ENOG4107XTC May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins HVX99_21775 ENOG4108ZIT Ferredoxin, 2FE-2S HVX99_21780 ENOG4105WVQ Fe-S assembly protein IscX HVX99_21790 ENOG4105YYA enhanced serine sensitivity protein SseB HVX99_21795 ENOG4105KHC sulfurtransferase HVX99_21800 ENOG4105DN3 alpha-2-macroglobulin domain protein HVX99_21805 ENOG4108JQB penicillin-binding protein 1C HVX99_21835 ENOG4105N21 Membrane HVX99_21850 ENOG4105VPD cellular component movement HVX99_21860 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) HVX99_21870 ENOG41066DY Membrane HVX99_21875 ENOG4108ZMA Outer membrane lipoprotein HVX99_21880 ENOG41062G3 Protein of unknown function (DUF2633) HVX99_21890 ENOG4105BZU Histidine kinase HVX99_21895 ENOG4105C9X ppx gppa phosphatase HVX99_21900 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) HVX99_21905 ENOG4108V3E phosphoribosylglycinamide formyltransferase HVX99_21920 ENOG4105C2W permease HVX99_21925 ENOG4108KZ1 Mediates the interaction of DNA replication inititator protein DnaA with DNA polymerase subunit beta sliding clamp (dnaN). Stimulates hydrolysis of ATP-DnaA to ADP-DnaA, rendering DnaA inactive for reinititation, a process called regulatory inhibition of DnaA or RIDA (By similarity) HVX99_21930 ENOG4105K89 arsenate reductase HVX99_21935 ENOG4105ERG peptidase m48, ste24p HVX99_21940 ENOG4105C02 permease HVX99_21945 ENOG4105TMB Formate nitrite transporter HVX99_21950 ENOG4108JUA Transcriptional regulator HVX99_21955 ENOG4105I6X formate hydrogenlyase maturation HVX99_21960 ENOG4105C47 NADH ubiquinone oxidoreductase 20 kda subunit HVX99_21970 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HVX99_21975 ENOG4108JPZ Monovalent cation H antiporter subunit D HVX99_21980 ENOG4107WQX hydrogenase 4 membrane subunit HVX99_21990 ENOG4107TDF Formate hydrogenlyase subunit 4 HVX99_22000 ENOG4108MFN small subunit of hydrogenase-3, iron-sulfur protein (part of formate hydrogenlyase (FHL) complex) HVX99_22005 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen HVX99_22010 ENOG4105RH4 Glycine cleavage system transcriptional repressor HVX99_22020 ENOG4107EG0 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) HVX99_22035 ENOG4105M0J Toxic component of a toxin-antitoxin (TA) module. A HVX99_22040 ENOG4105CGZ zinc metallopeptidase HVX99_22050 ENOG4106KED esterase YpfH HVX99_22065 ENOG4105KUZ arsenate reductase HVX99_22075 ENOG4105BZS acriflavin resistance protein HVX99_22080 ENOG4105BZU Histidine kinase HVX99_22085 ENOG4105BZ8 glutamate synthase HVX99_22095 ENOG4108PVD exported protein HVX99_22100 ENOG4105CV1 Transketolase (EC 2.2.1.1) HVX99_22105 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) HVX99_22110 ENOG4105C6K Malic enzyme HVX99_22115 ENOG4108VJN May be involved in the formation of a specific microcompartment in the cell in which the metabolism of potentially toxic by-products takes place HVX99_22120 ENOG4106S4J ethanolamine utilization protein EutP HVX99_22125 ENOG4105NDK ethanolamine utilization protein HVX99_22130 ENOG4108PFF ethanolamine utilization cobalamin adenosyltransferase HVX99_22135 ENOG4107WUY phosphate acetyltransferase HVX99_22140 ENOG4105KNY Microcompartments protein HVX99_22145 ENOG4105WVM ethanolamine utilization protein EutN carboxysome structural protein Ccml HVX99_22150 ENOG4108EKI Dehydrogenase HVX99_22155 ENOG4107RWI ethanolamine utilization protein eutJ HVX99_22160 ENOG4105C0A alcohol dehydrogenase HVX99_22165 ENOG4105ENY Ethanolamine utilization protein eutH HVX99_22170 ENOG4105DYY Reactivating factor for ethanolamine ammonia lyase HVX99_22175 ENOG4105CPD ethanolamine ammonia-lyase HVX99_22185 ENOG4106D67 ethanolamine utilization protein HVX99_22190 ENOG4108X49 Ethanolamine utilization protein EutK HVX99_22195 ENOG4108K3Z AraC family transcriptional regulator HVX99_22205 ENOG4108KNB n-acetylmuramoyl-l-alanine amidase HVX99_22215 ENOG4105QZU Inner membrane protein YfeZ HVX99_22220 ENOG4105E7K (LipO)protein HVX99_22225 ENOG4105EZR dyp-type peroxidase family protein HVX99_22230 ENOG4107S1E Beta-lactamase HVX99_22235 ENOG4105C5Y PTS System HVX99_22250 ENOG4105I7Z Short-chain dehydrogenase reductase Sdr HVX99_22255 ENOG4108J2H Sulfate ABC transporter periplasmic sulfate-binding protein HVX99_22260 ENOG4108I5D sulfate abc transporter HVX99_22265 ENOG4105ECW sulfate abc transporter HVX99_22270 ENOG4108IJ6 ABC transporter HVX99_22275 ENOG4105C6T cysteine synthase HVX99_22280 ENOG4105M0Y HVX99_22290 ENOG4105C5Y PTS System HVX99_22295 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) HVX99_22305 ENOG4105C6T cysteine synthase HVX99_22315 ENOG4107NPY receptor for the septal ring structure, may anchor it to the inner-membrane (By similarity) HVX99_22325 ENOG4105VRT cytoplasmic protein HVX99_22330 ENOG4105DHU Bile acid HVX99_22335 ENOG4108M0I Transcriptional regulator HVX99_22340 ENOG4108NFH Sugar hydrolase HVX99_22345 ENOG4107U5R The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity) HVX99_22350 ENOG4105EAA nucleoside HVX99_22360 ENOG4105CN8 Transcriptional regulator HVX99_22390 ENOG4105GXM Putative transcription regulator (DUF1323) HVX99_22395 ENOG4105HZG regulatoR HVX99_22410 ENOG4108KMM Diguanylate cyclase HVX99_22415 ENOG4105D9N nucleoside HVX99_22425 ENOG4109076 Conserved Protein HVX99_22440 ENOG4105R6B The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane (By similarity) HVX99_22445 ENOG410863U PTS System HVX99_22450 ENOG4105DC7 peptidase M24 HVX99_22455 ENOG4105CN9 Peptidase m42 family protein HVX99_22460 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) HVX99_22465 ENOG4108CIP transcriptional regulator HVX99_22470 ENOG4105DY9 regulatoR HVX99_22475 ENOG4108HRK Histidine kinase HVX99_22480 ENOG4105CHM Aminotransferase HVX99_22490 ENOG4105D1S lipid A biosynthesis HVX99_22495 ENOG4105W9M Membrane HVX99_22505 ENOG4108V08 YfdX protein HVX99_22515 ENOG4105CFN oxalyl-CoA decarboxylase HVX99_22520 ENOG4108N2Y auxin Efflux HVX99_22525 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F HVX99_22530 ENOG4105BZU Histidine kinase HVX99_22535 ENOG4108WQH regulatoR HVX99_22540 ENOG4105CW7 secretion protein, HlyD family HVX99_22545 ENOG4105C0R drug resistance transporter emrb qaca subfamily HVX99_22560 ENOG4106NDP Transcriptional regulator HVX99_22565 ENOG4108HKT sucrose-6-phosphate hydrolase HVX99_22570 ENOG4105D7K pfkb domain protein HVX99_22575 ENOG4105U0F oligosaccharide H symporter, major facilitator superfamily (MFS) HVX99_22585 ENOG4105S64 Formate nitrite transporter HVX99_22590 ENOG410903C (LipO)protein HVX99_22600 ENOG4105CKF membrane protein involved in aromatic hydrocarbon degradation HVX99_22605 ENOG4105KZW UPF0381 protein HVX99_22620 ENOG4108BY2 phosphohistidine phosphatase HVX99_22630 ENOG4106PG1 outer membrane usher protein HVX99_22635 ENOG4108FZ9 Chaperone HVX99_22640 ENOG4105NEV Fimbrial HVX99_22645 ENOG4105UGQ Fimbrial HVX99_22650 ENOG4105US4 fimbrial-like protein yfcP HVX99_22680 ENOG4105EJ9 Membrane HVX99_22685 ENOG4108BPE -transporting atpase HVX99_22690 ENOG4105MH2 YfcL protein HVX99_22695 ENOG4105CWG Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity) HVX99_22700 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) HVX99_22705 ENOG4105F9N Major Facilitator Superfamily HVX99_22710 ENOG4106WZ1 flagella biosynthesis regulator HVX99_22720 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) HVX99_22730 ENOG4105DQR SNARE associated Golgi HVX99_22740 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase HVX99_22745 ENOG4108S3P Sporulation domain protein HVX99_22750 ENOG4105E96 Colicin v production protein HVX99_22755 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase HVX99_22760 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase HVX99_22765 ENOG4105E89 ABC transporter HVX99_22770 ENOG4105E89 ABC transporter HVX99_22775 ENOG4105DSP amino acid AbC transporter HVX99_22780 ENOG4106YG3 ABC transporter HVX99_22785 ENOG4108JEH abc transporter atp-binding protein HVX99_22790 ENOG4105DNE Transposase HVX99_22795 ENOG4105ECP epimerase HVX99_22800 ENOG4105KKP D-erythro-7,8-dihydroneopterin triphosphate 2'-epimerase HVX99_22805 ENOG4105CYM Glutathione S-transferase HVX99_22810 ENOG4108SHQ Glutathione S-transferase HVX99_22815 ENOG4108RE9 Phosphodiesterase HVX99_22820 ENOG4105PTV Nudix Hydrolase HVX99_22825 ENOG4105CSX c4-dicarboxylate anaerobic carrier HVX99_22830 ENOG4105C6K Malic enzyme HVX99_22835 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) HVX99_22845 ENOG4105XWI UPF0304 protein HVX99_22850 ENOG4105EVE HAD-superfamily hydrolase subfamily IA variant 3 HVX99_22855 ENOG4107QWE )-transporter HVX99_22865 ENOG4105CHM Aminotransferase HVX99_22870 ENOG4107NQ8 LysR family Transcriptional regulator HVX99_22890 ENOG4105GKE subunit e HVX99_22895 ENOG4107QIZ NADH dehydrogenase HVX99_22900 ENOG4108IEH NADH dehydrogenase subunit g HVX99_22915 ENOG4107UFS subunit j HVX99_22925 ENOG4105D65 subunit l HVX99_22930 ENOG4105C8S subunit m HVX99_22940 ENOG4105GDX Domain of unknown function (DUF1877) HVX99_22960 ENOG4107YB6 acetyltransferase, (GNAT) family HVX99_22965 ENOG4105TNS Conserved Protein HVX99_22970 ENOG4105E4F Isochorismate synthase HVX99_22985 ENOG4108IPT Naphthoate synthase HVX99_22995 ENOG4105CEY Amp-dependent synthetase and ligase HVX99_23000 ENOG4106GZG polymyxin resistance protein B HVX99_23050 ENOG4108UII YfaZ family HVX99_23065 ENOG4105DNE Transposase HVX99_23070 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) HVX99_23080 ENOG4107R5Y anaerobic glycerol-3-phosphate dehydrogenase, subunit A HVX99_23085 ENOG4105CXY transporter HVX99_23090 ENOG4106MZZ glycerophosphoryl diester phosphodiesterase HVX99_23100 ENOG4105FQR PH-inducible protein involved in stress response HVX99_23105 ENOG4105XPH Ferredoxin HVX99_23110 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HVX99_23115 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HVX99_23120 ENOG4107GHC outer membrane autotransporter HVX99_23130 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HVX99_23135 ENOG4107FKF Uncharacterized protein conserved in bacteria (DUF2138) HVX99_23140 ENOG4108QJJ Protein of unknown function (DUF1175) HVX99_23145 ENOG4107S52 alpha-2-macroglobulin domain protein HVX99_23155 ENOG4105EDV vault protein HVX99_23160 ENOG4105BZU Histidine kinase HVX99_23165 ENOG41068CG regulatoR HVX99_23170 ENOG4105E3G Phosphotransfer intermediate protein in two-component regulatory system with RcsBC HVX99_23175 ENOG4105FCK Membrane HVX99_23180 ENOG4105CJ2 (LipO)protein HVX99_23185 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) HVX99_23190 ENOG4105CF1 Alkylated DNA repair protein HVX99_23195 ENOG4105IBP Cyclic peptide transporter HVX99_23210 ENOG4108ZNS ferredoxin-type protein NapF HVX99_23215 ENOG41061Q0 Assembly protein for periplasmic nitrate reductase HVX99_23225 ENOG4108BGM Quinol dehydrogenase periplasmic component HVX99_23230 ENOG4105GXZ Ferredoxin-type protein NapH HVX99_23235 ENOG4108ZMS Electron transfer subunit of the periplasmic nitrate reductase complex NapAB (By similarity) HVX99_23240 ENOG4105CUW cytochrome C-TYPE protein HVX99_23250 ENOG4105CA5 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes (By similarity) HVX99_23255 ENOG41060IM Heme exporter protein HVX99_23260 ENOG4105X3C heme exporter protein HVX99_23270 ENOG4105DA4 cytochrome c-type biogenesis protein HVX99_23275 ENOG4107QX9 Thiol disulfide interChange protein HVX99_23280 ENOG4105KWW Biogenesis protein HVX99_23285 ENOG4105WH1 Two component transcriptional regulator luxr family HVX99_23300 ENOG4105E68 Sulfatase HVX99_23320 ENOG4105CFI type iii restriction protein res subunit HVX99_23325 ENOG4105I08 Pseudouridine synthase HVX99_23330 ENOG4105C2C drug resistance transporter, Bcr CflA HVX99_23335 ENOG4105HG6 HVX99_23340 ENOG4108JQ5 ABC transporter HVX99_23345 ENOG4108IYQ Binding-protein-dependent transport systems inner membrane component HVX99_23350 ENOG4108I5X binding-protein-dependent transport systems inner membrane Component HVX99_23355 ENOG4105E43 Extracellular solute-binding protein, family 5 HVX99_23360 ENOG4105CXC rtn protein HVX99_23365 ENOG4107TT5 NLP P60 protein HVX99_23370 ENOG41076MN Phosphoesterase, PA-phosphatase related HVX99_23375 ENOG4105CKI cobalamin synthesis protein HVX99_23380 ENOG4105DEI Mannitol dehydrogenase HVX99_23390 ENOG4105KRS Proteinase inhibitor HVX99_23395 ENOG4105S8Q sugar efflux transporter HVX99_23400 ENOG4105DTZ bifunctional PTS system fructose-specific transporter subunit IIA HPr protein HVX99_23405 ENOG4105DE4 1-phosphofructokinase HVX99_23410 ENOG4105DM4 PTS System HVX99_23415 ENOG4105DD7 kinase (PfkB family HVX99_23420 ENOG4105D53 Catalyzes the hydrolysis of pseudouridine 5'-phosphate (PsiMP) to ribose 5-phosphate and uracil (By similarity) HVX99_23425 ENOG4105D9N nucleoside HVX99_23430 ENOG4108Y4K DNA-binding transcriptional activator HVX99_23440 ENOG4105D9N nucleoside HVX99_23445 ENOG4105DD7 kinase (PfkB family HVX99_23455 ENOG4105HMI Membrane HVX99_23460 ENOG4105DUM transcriptional regulator, lysR family HVX99_23465 ENOG4108IQI permease HVX99_23470 ENOG4105D05 Receptor HVX99_23485 ENOG4105DHF Membrane HVX99_23490 ENOG41060NJ transcriptional regulator HVX99_23495 ENOG4105EMA Periplasmic binding protein LacI transcriptional regulator HVX99_23500 ENOG4105C2J ABC transporter HVX99_23505 ENOG4108HWV )-transporter HVX99_23510 ENOG4107SJI Dehydrogenase HVX99_23515 ENOG4105BZ8 glutamate synthase HVX99_23520 ENOG4105Y9N Membrane HVX99_23525 ENOG4107GZ4 SanA protein HVX99_23535 ENOG41067MG lrgb family HVX99_23545 ENOG4105FBT Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity) HVX99_23555 ENOG4105ETP RND efflux system, outer membrane lipoprotein HVX99_23565 ENOG4105KHU inner membrane protein YohD HVX99_23570 ENOG41069YE inner membrane protein yohC HVX99_23575 ENOG41061WM D-Alanyl-D-Alanine HVX99_23580 ENOG4105CXG d-lactate dehydrogenase HVX99_23585 ENOG4107QK4 glycoside hydrolase, family 3 domain protein HVX99_23590 ENOG4107SI7 Substrate-binding region of abc-type glycine betaine transport system HVX99_23595 ENOG4107T5X Binding-protein-dependent transport systems, inner membrane component HVX99_23600 ENOG4108IJ8 ABC transporter HVX99_23605 ENOG4105WJV Binding-protein-dependent transport systems, inner membrane component HVX99_23615 ENOG4108XDN Transcriptional regulator HVX99_23620 ENOG4108HRK Histidine kinase HVX99_23625 ENOG4108NEV two component transcriptional regulator, LytTR family HVX99_23630 ENOG4108W15 Protein of unknown function (DUF1456) HVX99_23635 ENOG4108YCW (LipO)protein HVX99_23640 ENOG410903U zinc ion binding HVX99_23645 ENOG4105DEG Vwa containing coxe family protein HVX99_23650 ENOG4105RD5 HVX99_23655 ENOG4105KKX ATPase associated with various cellular activities aaa_5 HVX99_23665 ENOG4108KDT Molybdate metabolism regulator HVX99_23670 ENOG4108KDT Molybdate metabolism regulator HVX99_23680 ENOG4105D1F ATP-binding protein HVX99_23685 ENOG41067AK Protein of unknown function (DUF2574) HVX99_23690 ENOG41063W2 Fimbrial protein HVX99_23695 ENOG4108MQF Chaperone HVX99_23700 ENOG4105CW0 outer membrane usher protein HVX99_23705 ENOG410662B Type-1 fimbrial protein HVX99_23710 ENOG4108Z1S Influences nickel and cobalt homeostasis. May act by modulating RcnA-mediated export of these ions to avoid excess efflux. Not involved in nickel import and does not bind nickel or cobalt ions directly HVX99_23730 ENOG4105DWF phosphomethylpyrimidine kinase HVX99_23735 ENOG4108UQ1 hydrolase, family 25 HVX99_23740 ENOG4105FDP GntR family transcriptional regulator HVX99_23745 ENOG4108TFM Kinase, PfkB family HVX99_23750 ENOG4108KD5 ADP-ribosylation crystallin J1 HVX99_23755 ENOG4105EAA nucleoside HVX99_23760 ENOG4105EIE fructose-bisphosphate aldolase HVX99_23775 ENOG41082GB PTS system galactitol-specific transporter subunit IIA HVX99_23780 ENOG41090UW PTS System HVX99_23785 ENOG4105DT3 PTS system, galactitol-specific IIc component HVX99_23790 ENOG4107WTH Galactitol-1-phosphate dehydrogenase HVX99_23805 ENOG41076Z6 Uncharacterized protein yegR HVX99_23810 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HVX99_23890 ENOG4106PHM regulatory protein HVX99_23905 ENOG4105DWP Membrane HVX99_23925 ENOG4106CQM replication HVX99_23945 ENOG4107CBI conjugal transfer fertility inhibition protein HVX99_23950 ENOG4107U2T alpha beta HVX99_23970 ENOG4105M0J Toxic component of a toxin-antitoxin (TA) module. A HVX99_24200 ENOG4106JQ7 HVX99_24205 ENOG41073YN Protein of unknown function (DUF1380)