locus-tag class description HVY54_00010 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) HVY54_00020 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HVY54_00025 ENOG4105VP5 Bacterial protein of unknown function (DUF937) HVY54_00030 ENOG410667J hydrolase HVY54_00035 ENOG410657R replicase EC 2.7 HVY54_00045 ENOG4105D99 atp gtp-binding protein HVY54_00050 ENOG4105R2A (LipO)protein HVY54_00070 ENOG4105FDP GntR family transcriptional regulator HVY54_00075 ENOG4105CI1 PTS System HVY54_00080 ENOG4105F8D glycoside hydrolase family 4 HVY54_00085 ENOG4108AHD Transcriptional regulator HVY54_00090 ENOG4107RUZ Sss sodium solute transporter superfamily HVY54_00095 ENOG4105CBG Sulfatase HVY54_00100 ENOG4106DRA Inner membrane protein YidI HVY54_00105 ENOG4105VG5 Membrane HVY54_00110 ENOG4105JP4 Inner membrane protein yidG HVY54_00115 ENOG4105J13 transcriptional regulator HVY54_00120 ENOG4105E5M Multidrug resistance protein D HVY54_00135 ENOG4105C7K acetolactate synthase HVY54_00140 ENOG4105M71 acetolactate synthase 1 regulatory subunit HVY54_00155 ENOG4108KX4 response regulator HVY54_00160 ENOG4105BZU Histidine kinase HVY54_00165 ENOG4105CXY transporter HVY54_00170 ENOG4105CXY transporter HVY54_00175 ENOG4108SAJ Protein of unknown function (DUF1198) HVY54_00185 ENOG4105VCP PTS System HVY54_00190 ENOG4105CS2 ec 3.2.1.21 HVY54_00195 ENOG4105CK1 PTS System HVY54_00205 ENOG4105ETE Transcriptional regulator (LacI family HVY54_00220 ENOG4105C7N Xanthine uracil vitamin C permease HVY54_00225 ENOG4108SAJ Protein of unknown function (DUF1198) HVY54_00245 ENOG4108YAB Invasion protein HVY54_00250 ENOG4105IBT Required for translocation of effector proteins via the type III secretion system SPI-1, which is essential for an efficient bacterial internalization. Probably acts by modulating the secretion of SipA, SipB, and SipC HVY54_00275 ENOG4105T8A Uncharacterized protein YicS HVY54_00280 ENOG4105D01 (LipO)protein HVY54_00285 ENOG4108UZ3 Transporter HVY54_00290 ENOG4105S8Q sugar efflux transporter HVY54_00335 ENOG4108UUM single-stranded DNA-binding protein HVY54_00345 ENOG4105DPW Major facilitator superfamily MFS_1 HVY54_00350 ENOG4105CQ4 Transcriptional regulator HVY54_00360 ENOG4105DFP Integrase HVY54_00370 ENOG4105CT4 transporter HVY54_00375 ENOG4105CJQ hydrolase, family 31 HVY54_00385 ENOG4105C2W permease HVY54_00390 ENOG4105D6U Sodium Glutamate Symporter HVY54_00395 ENOG4105CB5 ATP-dependent DNA helicase recG HVY54_00400 ENOG4105FE8 tRNA (Guanosine-2'-O-)-methyltransferase HVY54_00405 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) HVY54_00415 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) HVY54_00425 ENOG4105EN6 Membrane HVY54_00435 ENOG4105DSJ YicC domain protein HVY54_00450 ENOG4107RRE RNA-directed DNA polymerase HVY54_00460 ENOG4108Z1K This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) HVY54_00465 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase HVY54_00475 ENOG4105KDC 50s ribosomal protein l28 HVY54_00495 ENOG4105D8A 3-Deoxy-D-manno-octulosonic-acid transferase HVY54_00500 ENOG4105DKP glycosyl transferase, family 9 HVY54_00505 ENOG4107RJ7 Glycosyl transferase (Group 1 HVY54_00510 ENOG4107543 (lipo)polysaccharide HVY54_00515 ENOG4106AH0 Glycosyl Transferase HVY54_00520 ENOG4105X1N Glycosyl transferase family 8 HVY54_00530 ENOG4105X1N Glycosyl transferase family 8 HVY54_00545 ENOG4105D16 lipopolysaccharide heptosyltransferase i HVY54_00550 ENOG4105XA0 heptosyltransferase ii HVY54_00560 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) HVY54_00570 ENOG4105K64 Glycosyl transferase, family 2 HVY54_00575 ENOG4105PXI polysaccharide deacetylase HVY54_00580 ENOG41063SB peptidase HVY54_00590 ENOG4107YZP Rhodanese domain protein HVY54_00595 ENOG4105VW4 glutaredoxin 3 HVY54_00610 ENOG4105D7W serine acetyltransferase HVY54_00615 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) HVY54_00625 ENOG41073TP transcriptional regulator HVY54_00630 ENOG4105DAA L-lactate HVY54_00635 ENOG4105EUR Domain-Containing protein HVY54_00640 ENOG4108WY4 inner membrane lipoprotein HVY54_00645 ENOG4108YYI Protein of unknown function (DUF2810) HVY54_00655 ENOG4105E61 Mannitol repressor protein HVY54_00665 ENOG4105CTS PTS system mannitol-specific HVY54_00670 ENOG4105FP6 Protein of unknown function (DUF3302) HVY54_00675 ENOG4105EFX secretion protein, HlyD family HVY54_00720 ENOG4108BMY protease HVY54_00725 ENOG4108U78 Glutathione S-transferase HVY54_00735 ENOG4105EM7 Selenocysteine-specific translation elongation factor HVY54_00740 ENOG4105C0A alcohol dehydrogenase HVY54_00745 ENOG4105C26 Dehydrogenase HVY54_00755 ENOG4105KK7 inner membrane protein YiaW HVY54_00760 ENOG4105EFX secretion protein, HlyD family HVY54_00765 ENOG4108Q2M Transcriptional regulator HVY54_00770 ENOG4105GNX MltA-interacting MipA family protein HVY54_00780 ENOG4105CT4 transporter HVY54_00795 ENOG4108XIB electron transport protein ysaA HVY54_00800 ENOG4105JKW Valine--pyruvate aminotransferase HVY54_00805 ENOG4107T9C Alpha amylase catalytic region HVY54_00810 ENOG4108UR8 BAX protein HVY54_00815 ENOG4105T16 Transcriptional regulator (AraC family) HVY54_00820 ENOG4108HWW ABC transporter HVY54_00830 ENOG4105DFW ABC transporter HVY54_00840 ENOG4105CMG Carbohydrate kinase HVY54_00845 ENOG410688U Inner membrane protein yiaB HVY54_00850 ENOG4108Z12 YiaAB two helix domain-containing protein HVY54_00855 ENOG4105MEV Acyl-transferase HVY54_00875 ENOG41060TC Hok gef cell toxic protein HVY54_00885 ENOG4105MVF Transcriptional regulator HVY54_00890 ENOG4106JH6 (LipO)protein HVY54_00900 ENOG4108ZG0 Ompa motb domain protein HVY54_00905 ENOG4107QY8 reductase HVY54_00910 ENOG4105HNP -acetyltransferase HVY54_00915 ENOG4108R3E Dna-3-methyladenine glycosylase i HVY54_00920 ENOG4105EAX Putative lipase HVY54_00925 ENOG4105FCD Major Facilitator HVY54_00930 ENOG4106EAR Fimbrial protein HVY54_00935 ENOG4108VCD Chaperone HVY54_00940 ENOG4105CW0 outer membrane usher protein HVY54_00945 ENOG4105MHR Fimbrial protein HVY54_00950 ENOG4106UCC Fimbrial protein HVY54_00955 ENOG4105DIJ Phosphoethanolamine transferase HVY54_00965 ENOG4105DEF Extracellular solute-binding protein, family 5 HVY54_00975 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HVY54_00980 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HVY54_00985 ENOG4105C3U ABC transporter HVY54_00990 ENOG4108JQ7 (ABC) transporter HVY54_00995 ENOG4105C44 Serine transporter HVY54_01015 ENOG4105D1V cellulose synthase operon protein YhjU HVY54_01020 ENOG4105WQA Cellulose biosynthesis protein BcsF HVY54_01025 ENOG4105U74 cellulose biosynthesis protein BcsE HVY54_01030 ENOG410661M cytoplasmic protein HVY54_01040 ENOG4107QZ7 Cellulose synthase catalytic subunit HVY54_01045 ENOG4107EEX Cellulose synthase regulator protein HVY54_01050 ENOG4105K2Z endo-1,4-d-glucanase (EC 3.2.1.4) HVY54_01055 ENOG4105EJG cellulose synthase HVY54_01060 ENOG4105BZU Histidine kinase HVY54_01070 ENOG4105CS0 peptidase HVY54_01080 ENOG4105CMB EAL domain-containing protein HVY54_01085 ENOG41066T0 asmA family HVY54_01090 ENOG4105CSH Transporter HVY54_01095 ENOG4107H3J ribonuclease HVY54_01100 ENOG4105CBN LysR family transcriptional regulator HVY54_01105 ENOG4106S2D Transcriptional regulator HVY54_01115 ENOG4105CA0 peroxidase HVY54_01120 ENOG4105CVK Glutamate decarboxylase HVY54_01125 ENOG4108NKV transcriptional regulator HVY54_01135 ENOG4105BZS acriflavin resistance protein HVY54_01140 ENOG4105C1P efflux transporter, rnd family, mfp subunit HVY54_01150 ENOG4106WJ0 Regulates the expression of several genes involved in acid resistance. Required for the expression of gadA and gadBC, among others, regardless of media or growth conditions. Binds directly to the 20 bp GAD box found in the control regions of both loci HVY54_01155 ENOG4108YK4 Acid-resistance membrane protein HVY54_01160 ENOG41060V2 Acid-resistance protein HVY54_01165 ENOG4105XXV Acid-resistance protein HVY54_01170 ENOG4105KT7 mgtC SapB transporter HVY54_01175 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) HVY54_01180 ENOG4105EHG Permease protein HVY54_01190 ENOG41090JE Utilization Protein HVY54_01195 ENOG4105D4P Coproporphyrinogen iii oxidase HVY54_01200 ENOG4107R4I Periplasmic binding protein HVY54_01205 ENOG4107ENK receptor HVY54_01210 ENOG4106QJH hemin transport protein HVY54_01220 ENOG4105Y4Z Outer Membrane Lipoprotein HVY54_01230 ENOG4105K89 arsenate reductase HVY54_01245 ENOG4105DC8 reductase HVY54_01250 ENOG4105D6S protein involved in catabolism of external DNA HVY54_01255 ENOG4105DGW oligopeptidase A HVY54_01265 ENOG4105DUX Transporter HVY54_01280 ENOG4105CJ3 phosphate transporter HVY54_01285 ENOG4105CBX hi0933 family HVY54_01290 ENOG4107UNS conserved inner membrane protein HVY54_01305 ENOG4105D0S secretion protein (HlyD HVY54_01310 ENOG4105CJ1 ABC, transporter HVY54_01315 ENOG4105CMI transporter HVY54_01340 ENOG4106665 Part of the ABC transporter complex NikABCDE involved in nickel import. Responsible for energy coupling to the transport system (By similarity) HVY54_01345 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HVY54_01350 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HVY54_01355 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein HVY54_01360 ENOG4107YAK holo-(acyl carrier protein) synthase 2 HVY54_01365 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) HVY54_01370 ENOG4105C2D reductase HVY54_01380 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) HVY54_01405 ENOG4106N3V dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83) HVY54_01435 ENOG4105E9Q Acyl-transferase HVY54_01455 ENOG4105DSF transport protein HVY54_01460 ENOG4105F9N Major Facilitator Superfamily HVY54_01465 ENOG4108W1V Lipoprotein HVY54_01470 ENOG4105EX9 Membrane HVY54_01485 ENOG4107FS9 Membrane HVY54_01495 ENOG4105MG3 Membrane HVY54_01500 ENOG4106H78 methyltransferase HVY54_01505 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) HVY54_01510 ENOG4105CAK Cell division ATP-binding protein ftsE HVY54_01515 ENOG4105CRP Part of the ABC transporter FtsEX involved in HVY54_01520 ENOG4105DEK Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HVY54_01525 ENOG4105CP9 extracellular ligand-binding receptor HVY54_01530 ENOG4105U59 -acetyltransferase HVY54_01535 ENOG4105CP9 extracellular ligand-binding receptor HVY54_01540 ENOG4105C32 Amino acid ABC transporter (Permease) HVY54_01545 ENOG4105CF8 branched-chain amino acid ABC transporter, permease HVY54_01550 ENOG4105C0Z ABC transporter HVY54_01555 ENOG4108IV0 ABC, transporter HVY54_01565 ENOG4105BZ7 extracellular solute-binding protein family 1 HVY54_01570 ENOG4105E4X binding-protein-dependent transport systems inner membrane Component HVY54_01575 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component HVY54_01585 ENOG4107T6V glycerophosphoryl diester phosphodiesterase HVY54_01590 ENOG4105WC8 Conserved Protein HVY54_01595 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) HVY54_01600 ENOG4106FA4 HVY54_01615 ENOG4105GMB type VI secretion system effector, hcp1 family HVY54_01620 ENOG4105WCN acetyltransferase HVY54_01625 ENOG4105D9R oxidoreductase HVY54_01630 ENOG4105C2I pirin domain protein HVY54_01635 ENOG4105DIQ Transcriptional regulator HVY54_01640 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family HVY54_01645 ENOG4105C6Z Gluconate HVY54_01650 ENOG4105C9U ATP-dependent DNA helicase RecQ HVY54_01660 ENOG41076UM multiple antibiotic resistance (MarC)-related protein HVY54_01665 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) HVY54_01670 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) HVY54_01690 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) HVY54_01710 ENOG4105C6V Glycerol-3-phosphate dehydrogenase HVY54_01725 ENOG4105E98 transcriptional regulator DeoR family HVY54_01730 ENOG4105CYB regulatoR HVY54_01735 ENOG4105E0Y RtcB Protein HVY54_01760 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) HVY54_01765 ENOG4107RTM 4-alpha-glucanotransferase (EC 2.4.1.25) HVY54_01770 ENOG4105C6Z Gluconate HVY54_01780 ENOG4105MJ2 Competence protein HVY54_01800 ENOG4105DNE Transposase HVY54_01810 ENOG4105CE1 Ferrous iron transport protein b HVY54_01815 ENOG4105XFK Ferrous iron transport protein A HVY54_01820 ENOG4105BZM domain protein HVY54_01825 ENOG4108RRZ Transcription elongation factor GreB HVY54_01835 ENOG4105E0F Histidine kinase HVY54_01845 ENOG4108MAJ Membrane HVY54_01855 ENOG4105VEJ Heat shock protein HVY54_01860 ENOG4107Y3D HAD-superfamily hydrolase subfamily IA variant 3 HVY54_01865 ENOG4105DQY intracellular growth attenuator HVY54_01870 ENOG4107RK2 ADP-ribose diphosphatase NudE HVY54_01875 ENOG4108JQC penicillin-binding protein 1A HVY54_01880 ENOG4108U1Q Pilus assembly protein HVY54_01885 ENOG41065NF Fimbrial assembly family protein HVY54_01890 ENOG4105XPX DNA utilization protein HofO HVY54_01895 ENOG4105ITY Required for the use of extracellular DNA as a nutrient HVY54_01900 ENOG4105E4G Type IV pilus HVY54_01915 ENOG4105EGB membrane protein DamX HVY54_01920 ENOG4105DFE Dna adenine methylase HVY54_01925 ENOG4105DJV ribulose-phosphate 3-epimerase HVY54_01930 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) HVY54_01935 ENOG4105C31 Tryptophanyl-tRNA synthetase HVY54_01940 ENOG4108M21 HVY54_01945 ENOG4105RMW regulation of transcription, DNA-dependent HVY54_01950 ENOG4108626 Racemase HVY54_01955 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) HVY54_01960 ENOG41080QX K07048 phosphotriesterase-related protein HVY54_01965 ENOG4105MUZ Protein of unknown function DUF2620 HVY54_01970 ENOG4106M0N transport system permease protein HVY54_01975 ENOG4106PKC pyridoxal phosphate binding HVY54_01980 ENOG4105FDP GntR family transcriptional regulator HVY54_01985 ENOG4108KPW sugar kinase HVY54_01990 ENOG4107Y0V Not clear, may be involved in an isomerization step HVY54_01995 ENOG4107R1S catalyzes the conversion of fructoselysine 6-phosphate to glucose 6-phosphate and lysine HVY54_02000 ENOG4107QHQ amino acid HVY54_02005 ENOG4105VYH HVY54_02015 ENOG4107V9H nitrite transporter HVY54_02020 ENOG4105WZK nitrite reductase NADPH small subunit HVY54_02025 ENOG4107QZF nitrite reductase NADPH large subunit HVY54_02035 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) HVY54_02045 ENOG4105MZU cell filamentation protein HVY54_02050 ENOG4105DDQ anthranilate synthase HVY54_02055 ENOG4105C8Y Acetylornithine aminotransferase HVY54_02060 ENOG410613R integral membrane protein, YccS YhfK family HVY54_02070 ENOG4108UKZ OsmC family HVY54_02075 ENOG4105CJE phosphoribulokinase (EC 2.7.1.19) HVY54_02085 ENOG4105DNZ Alpha Beta Hydrolase HVY54_02090 ENOG4105C5H ABC transporter HVY54_02105 ENOG4105VKU nucleicacid-binding protein HVY54_02110 ENOG4108YZY peptidylprolyl cis-trans isomerase HVY54_02120 ENOG4108V1T peptidylprolyl cis-trans isomerase HVY54_02125 ENOG4105WWK YheO domain protein HVY54_02135 ENOG4108ZKU Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions (By similarity) HVY54_02140 ENOG4105YKK Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions (By similarity) HVY54_02165 ENOG4105W53 bacterioferritin-associated ferredoxin HVY54_02170 ENOG4108UQY Iron-storage protein HVY54_02195 ENOG41080KG One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) HVY54_02240 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) HVY54_02285 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) HVY54_02290 ENOG41067V7 50S ribosomal protein L36 HVY54_02320 ENOG4105VTS DnaJ-like, subfamily C HVY54_02325 ENOG4105W1Y Transcriptional regulator HVY54_02330 ENOG4105VCN Rescues the ribosomes stalled at the 3' end of non-stop mRNAs. May induce hydrolysis of the ribosome-bound peptidyl-tRNA. This activity is crucial when the stalled ribosome can not be rescued by the SsrA(tmRNA)-SmpB quality control system HVY54_02340 ENOG4105C1A potassium transporter peripheral membrane HVY54_02360 ENOG4105C79 DNA protecting protein DprA HVY54_02370 ENOG4108WI1 Dna topoisomerase HVY54_02375 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) HVY54_02385 ENOG4105SG3 Protein of unknown function (DUF1488) HVY54_02390 ENOG4108Z0R Transferase HVY54_02430 ENOG4105CDA abc transporter atp-binding protein HVY54_02435 ENOG4105DRP amino acid AbC transporter HVY54_02440 ENOG4105EZ7 amino acid ABC transporter HVY54_02450 ENOG4105XCM membrane LIPOPROTEIN HVY54_02455 ENOG4105BZS acriflavin resistance protein HVY54_02460 ENOG4105C1P efflux transporter, rnd family, mfp subunit HVY54_02465 ENOG4108XG4 DNA-binding transcriptional regulator HVY54_02470 ENOG41061ME transport protein HVY54_02475 ENOG4105CEC DNA methylase N-4 N-6 HVY54_02485 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) HVY54_02495 ENOG4108IA2 Sodium pantothenate symporter HVY54_02500 ENOG4105RG0 Membrane HVY54_02505 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase HVY54_02510 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein HVY54_02520 ENOG4105D3Z quinone oxidoreductase, yhdh yhfp family HVY54_02525 ENOG41062P1 Diguanylate cyclase phosphodiesterase HVY54_02535 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) HVY54_02540 ENOG4105VQ7 Rod shape-determining protein MreD HVY54_02545 ENOG4108Z03 MAF-like protein HVY54_02550 ENOG4105C03 ribonuclease HVY54_02555 ENOG4105QD6 exported protein HVY54_02560 ENOG4105D1U peptidase U62 modulator of DNA gyrase HVY54_02565 ENOG4105CR8 Transcriptional regulator HVY54_02570 ENOG4105ZQC membrane protein AaeX HVY54_02585 ENOG4105UNR (Barnase) inhibitor HVY54_02590 ENOG4105RID UPF0379 protein yhcN HVY54_02605 ENOG4105C0H protease HVY54_02610 ENOG4105C0H protease HVY54_02615 ENOG4108W2Q Cytochrome d ubiquinol oxidase subunit III HVY54_02620 ENOG4105D6Z AFG1 family ATPase HVY54_02635 ENOG4107MKT Stringent starvation protein a HVY54_02640 ENOG4105KB2 stringent starvation protein b HVY54_02645 ENOG4105CEE C4-dicarboxylate transporter HVY54_02650 ENOG4108QBF Transcriptional regulator HVY54_02660 ENOG4105JHE Major Facilitator Superfamily HVY54_02675 ENOG4108R66 Conserved Protein HVY54_02680 ENOG4105DFS Conserved Protein HVY54_02685 ENOG4105BZ8 glutamate synthase HVY54_02690 ENOG4105CBC glutamate synthase HVY54_02695 ENOG4105N5T Radical SAM Protein HVY54_02700 ENOG4105BZU Histidine kinase HVY54_02705 ENOG4108556 Isoprenoid biosynthesis protein with amidotransferase-like domain HVY54_02715 ENOG4108NIH transferase activity, transferring phosphorus-containing groups HVY54_02720 ENOG41080Z8 PHOSPHOCARRIER protein HVY54_02730 ENOG4107RM2 PTS IIA-like nitrogen-regulatory protein PtsN HVY54_02735 ENOG41080QH sigma 54 modulation protein ribosomal protein S30EA HVY54_02740 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HVY54_02745 ENOG4108IUZ ABC transporter HVY54_02750 ENOG4105WI0 lipopolysaccharide transport periplasmic protein lptA HVY54_02755 ENOG4108P1K Required for the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane (By similarity) HVY54_02760 ENOG4108Z4R 3-deoxy-d-manno-octulosonate 8-phosphate phosphatase HVY54_02765 ENOG4105C2X Arabinose 5-phosphate isomerase HVY54_02770 ENOG4105FEU K -dependent Na -Ca exchanger HVY54_02775 ENOG4105DHJ ABC, transporter HVY54_02780 ENOG4105CY3 ABC transporter, permease HVY54_02785 ENOG4107PE3 Mammalian cell entry related domain protein HVY54_02790 ENOG4105E3I toluene tolerance HVY54_02795 ENOG4105UE2 Part of the ABC transporter complex MlaFEDB that actively prevents phospholipid accumulation at the cell surface. Probably maintains lipid asymmetry in the outer membrane by retrograde trafficking of phospholipids from the outer membrane to the inner membrane HVY54_02800 ENOG4105VFK BolA family HVY54_02810 ENOG4105HVQ Regulatory factor of maltose metabolism HVY54_02815 ENOG4105EAH synthase HVY54_02830 ENOG4105QYV Membrane HVY54_02840 ENOG4106HRJ d-alanyl-d-alanine carboxypeptidase HVY54_02845 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) HVY54_02850 ENOG4105HBR Rna-binding protein HVY54_02860 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) HVY54_02865 ENOG4105EEI dihydropteroate synthase HVY54_02875 ENOG4105NTZ Preprotein translocase subunit SecG HVY54_02885 ENOG4105DIJ Phosphoethanolamine transferase HVY54_02905 ENOG4105CHV Transcription elongation factor NusA HVY54_02945 ENOG4105C1J atp-dependent rna helicase HVY54_02950 ENOG4105CIC tryptophan-specific transport protein HVY54_02955 ENOG4105DEN Luciferase family HVY54_02975 ENOG4108YYD acetyltransferase HVY54_02990 ENOG4107R7Y intracellular protease Pfpi family HVY54_02995 ENOG4105K4T epimerase HVY54_03000 ENOG4107S21 permease HVY54_03005 ENOG4105W4M Transport-associated protein HVY54_03020 ENOG4105E1C Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1A (PBP1a) (By similarity) HVY54_03025 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) HVY54_03040 ENOG4106HBN Galactosamine-6-phosphate isomerase HVY54_03045 ENOG4105F3R pts system mannose fructose sorbose family iid HVY54_03050 ENOG4105ETZ PTS System HVY54_03055 ENOG4108UZY PTS System HVY54_03065 ENOG4105E70 isomerase HVY54_03070 ENOG4105CE4 GlcNAc 6-P deacetylase HVY54_03075 ENOG4108YTN IIa component HVY54_03080 ENOG4105F3R pts system mannose fructose sorbose family iid HVY54_03090 ENOG4108RG5 PTS system N-acetylgalactosamine-specific transporter subunit IIB HVY54_03100 ENOG4105E98 transcriptional regulator DeoR family HVY54_03110 ENOG4105ZEG Suppressor protein HVY54_03115 ENOG4105CTX dehydratase HVY54_03120 ENOG4105DJB Major Facilitator Superfamily HVY54_03130 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase HVY54_03135 ENOG4105BZW Glycerate kinase HVY54_03160 ENOG410811B TRANSCRIPTIONal HVY54_03165 ENOG4105C7B Threonine dehydratase HVY54_03170 ENOG4108MST Involved in the import of threonine and serine into the cell, with the concomitant import of a proton (symport system) (By similarity) HVY54_03175 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) HVY54_03180 ENOG4105C6N Formate acetyltransferase HVY54_03185 ENOG4105KME endoribonuclease L-psp HVY54_03190 ENOG4105EJQ L-serine dehydratase HVY54_03195 ENOG4105C44 Serine transporter HVY54_03205 ENOG4106D80 Uncharacterized protein YhaL HVY54_03210 ENOG4108CNN domain protein HVY54_03215 ENOG4105CWB LysR family transcriptional Regulator HVY54_03220 ENOG4105KAF membrAne HVY54_03225 ENOG4105KAF membrAne HVY54_03230 ENOG4105CHF Glutathione S-transferase HVY54_03235 ENOG4108VBZ doxx family HVY54_03240 ENOG4105YJD HVY54_03245 ENOG41090KG Inner membrane protein YqjE HVY54_03250 ENOG4105NE1 Conserved Protein HVY54_03255 ENOG4105WAY exported protein HVY54_03260 ENOG4105IYR Modulates the activity of the EnvZ OmpR two-component regulatory system, probably by directly modulating EnvZ enzymatic activity and increasing stability of phosphorylated OmpR (By similarity) HVY54_03265 ENOG4106W5V Membrane HVY54_03270 ENOG4107YCY Transcriptional regulator HVY54_03275 ENOG4105DPW Major facilitator superfamily MFS_1 HVY54_03285 ENOG4105CTX dehydratase HVY54_03290 ENOG4105P66 Membrane HVY54_03295 ENOG4107QV7 Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system) (By similarity) HVY54_03300 ENOG4105DU1 integral membrane protein, terc HVY54_03305 ENOG4105EE0 oxidoreductase HVY54_03310 ENOG4108UB4 uncharacterized protein ygjQ HVY54_03315 ENOG4108VKG metal-dependent hydrolase HVY54_03325 ENOG4105R48 this blockage is overcome by subsequent expression of antitoxin HigA. Overexpression causes cleavage of a number of mRNAs in a translation-dependent fashion, suggesting this is an mRNA interferase HVY54_03330 ENOG4108Z3N Transcriptional regulator HVY54_03335 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HVY54_03340 ENOG4107WCA isomerase HVY54_03345 ENOG4107W6W Conserved Protein HVY54_03350 ENOG4105E5D amino acid HVY54_03355 ENOG4105FK9 beta-D-galactosidase beta subunit HVY54_03360 ENOG4105CNT hydrolase family 2 HVY54_03365 ENOG4105CQ4 Transcriptional regulator HVY54_03370 ENOG4108Y51 tRNA-binding protein HVY54_03380 ENOG4107RHT methyl-accepting chemotaxis sensory transducer with Pas Pac sensor HVY54_03385 ENOG4105NTW Transcriptional regulator HVY54_03390 ENOG4105Q26 Siderophore-interacting protein HVY54_03405 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HVY54_03410 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) HVY54_03425 ENOG4107QPK )-transporter HVY54_03430 ENOG4107GFK fumarate HVY54_03435 ENOG4106DSS Tartrate dehydratase subunit alpha HVY54_03440 ENOG4105EJC lysr family transcriptional regulator HVY54_03450 ENOG4107ZVW dihydroneopterin aldolase HVY54_03465 ENOG4106MWK domain protein HVY54_03470 ENOG4105I7R Adenylate cyclase HVY54_03495 ENOG4107S78 Band 7 protein HVY54_03500 ENOG4105PV3 Inner membrane protein yqiJ HVY54_03510 ENOG4105W0Z cytoplasmic protein HVY54_03530 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b HVY54_03535 ENOG4106032 Glutathionylspermidine synthase HVY54_03545 ENOG4105DFG type I secretion outer membrane protein HVY54_03550 ENOG41087AY ADP-Ribose pyrophosphatase HVY54_03555 ENOG4108SX3 cytoplasmic protein HVY54_03560 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) HVY54_03565 ENOG4105IPS esterase HVY54_03570 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HVY54_03580 ENOG4105E0A ABC, transporter HVY54_03585 ENOG4105DQ5 transport system permease protein HVY54_03590 ENOG4105EHG Permease protein HVY54_03600 ENOG4106KNT transcriptional regulator HVY54_03605 ENOG4105VRH Antibiotic biosynthesis monooxygenase HVY54_03610 ENOG4105NF4 modulator of drug activity HVY54_03615 ENOG4105DHQ Histidine kinase HVY54_03620 ENOG4105XJC Two component transcriptional regulator (Winged helix family HVY54_03625 ENOG4105H4F exported protein HVY54_03630 ENOG4105F4I Transcriptional regulator HVY54_03635 ENOG4108J59 Extracellular solute-binding protein, family 5 HVY54_03640 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HVY54_03645 ENOG4107S7E 1-acyl-sn-glycerol-3-phosphate acyltransferase HVY54_03650 ENOG4107TZ2 Cell division protein that is required for growth during stress conditions. May be involved in protecting or stabilizing the divisomal assembly under conditions of stress (By similarity) HVY54_03655 ENOG4105CCT upf0313 protein HVY54_03665 ENOG4105ZKC Conserved Protein HVY54_03670 ENOG4105CV8 reductase HVY54_03675 ENOG4108I6A alcohol dehydrogenase HVY54_03680 ENOG4105CF7 AraC family transcriptional regulator HVY54_03685 ENOG4108K81 inner membrane protein YghB HVY54_03690 ENOG4105C28 cystathionine HVY54_03695 ENOG4105CWK Biopolymer transport protein, ExbB HVY54_03700 ENOG4108ZZF transport protein (ExbD) HVY54_03705 ENOG4105CYX Short-chain dehydrogenase reductase Sdr HVY54_03715 ENOG4105CPC Aldo Keto reductase HVY54_03725 ENOG410900S Protein of unknown function (DUF2623) HVY54_03730 ENOG4105E3S small subunit HVY54_03735 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein HVY54_03740 ENOG4105CJ5 hydrogenase 2 b cytochrome subunit HVY54_03745 ENOG4105DPX Hydrogenase, large subunit HVY54_03750 ENOG4108USZ hydrogenase HVY54_03755 ENOG4108WGS hydrogenase 2-specific chaperone HVY54_03765 ENOG41082MF Hydrogenase assembly chaperone hypC hupF HVY54_03770 ENOG4105CYM Glutathione S-transferase HVY54_03775 ENOG4106032 Glutathionylspermidine synthase HVY54_03780 ENOG4105CJ3 phosphate transporter HVY54_03785 ENOG4108GH0 ATP-binding protein yghT HVY54_03790 ENOG4108NDC ATP-binding protein yghS HVY54_03795 ENOG4106FPV ATP-binding protein YghR HVY54_03800 ENOG4108S55 polysaccharide biosynthesis protein HVY54_03810 ENOG4108UUE Transcriptional regulator HVY54_03815 ENOG4108M8S permease YjgP YjgQ family protein HVY54_03825 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) HVY54_03830 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) HVY54_03840 ENOG4107RCI amp-dependent synthetase and ligase HVY54_03850 ENOG4108KWP DNA-binding transcriptional regulator GlcC HVY54_03855 ENOG4105CQB FAD linked oxidase domain protein HVY54_03860 ENOG4105EU8 FAD linked oxidase domain protein HVY54_03865 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) HVY54_03870 ENOG4108ZJF Glcg protein HVY54_03875 ENOG4107QP3 malate synthase g HVY54_03880 ENOG4105DAA L-lactate HVY54_04015 ENOG4108UQV Membrane HVY54_04020 ENOG4105CXN decarboxylase HVY54_04025 ENOG4105EAA nucleoside HVY54_04040 ENOG4105CEN a g-specific adenine glycosylase HVY54_04050 ENOG41090ED Protein with unknown function (DUF469) HVY54_04055 ENOG4105K33 Periplasmic Protein HVY54_04060 ENOG4105HDK L-asparaginase HVY54_04065 ENOG4106MH3 alpha helix chain HVY54_04070 ENOG4105CSA Coproporphyrinogen iii oxidase HVY54_04075 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) HVY54_04085 ENOG4108VIA integral membrane protein HVY54_04090 ENOG4105DFA alanine racemase domain protein HVY54_04095 ENOG4105CZX twitching motility protein HVY54_04110 ENOG4105D7Z glutathione synthase HVY54_04115 ENOG4105QF0 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) HVY54_04120 ENOG4105RWS endonuclease I HVY54_04130 ENOG4107QNK )-transporter HVY54_04150 ENOG4105DP5 Catalyzes the biosynthesis of agmatine from arginine (By similarity) HVY54_04165 ENOG4108K0D peptidase, M48 HVY54_04170 ENOG4105CV1 Transketolase (EC 2.2.1.1) HVY54_04175 ENOG4105EPW hflc protein HVY54_04180 ENOG4108X7Y Mannitol-specific cryptic phosphotransferase enzyme iia HVY54_04185 ENOG4105CTS PTS system mannitol-specific HVY54_04190 ENOG4105DXH Alcohol dehydrogenase zinc-binding domain protein HVY54_04195 ENOG4108Q8A Fructose-1,6-bisphosphatase HVY54_04200 ENOG4108R4K DNA-binding, transcriptional regulator HVY54_04205 ENOG4107Z1W Fructose transport system kinase HVY54_04210 ENOG4108JJB ABC transporter HVY54_04215 ENOG4108JJB ABC transporter HVY54_04245 ENOG4105D2N Aldolase HVY54_04250 ENOG4105D64 Mechanosensitive ion channel HVY54_04265 ENOG4108ZUB Lysine exporter protein (Lyse ygga) HVY54_04270 ENOG4105MPN Membrane HVY54_04275 ENOG4105DEQ transcriptional regulator HVY54_04280 ENOG4105CYC Transferase HVY54_04285 ENOG4108M7F enoyl-CoA hydratase isomerase HVY54_04290 ENOG4105DJT lAO AO transport system ATPase HVY54_04295 ENOG4105D5P Methylmalonyl-coA mutase HVY54_04315 ENOG4108JQ1 Dehydrogenase HVY54_04325 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase HVY54_04345 ENOG4107RAQ aminopeptidase HVY54_04350 ENOG4105D0A hydroxylase HVY54_04355 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family HVY54_04380 ENOG4105CS2 ec 3.2.1.21 HVY54_04385 ENOG4105N5Z UPF0267 protein HVY54_04390 ENOG4108UT2 hemolysin iii HVY54_04400 ENOG4105Y75 tpr repeat protein HVY54_04405 ENOG4108YDB Toxic component of a toxin-antitoxin (TA) module. Overexpression leads to growth arrest after 5 hours, with initial elongation of cells, followed by swelling. The toxic effects are abrogated by coexpression with antitoxin CptB. Interacts with cytoskeletal proteins FtsZ and MreB HVY54_04410 ENOG41071R3 Low-potential electron donor to a number of redox enzymes (By similarity) HVY54_04415 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HVY54_04420 ENOG4105T95 Thiol disulfide interChange protein HVY54_04425 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) HVY54_04435 ENOG4105CRK lysyL-tRNA synthetase HVY54_04455 ENOG4105C2W permease HVY54_04460 ENOG4105BZ8 glutamate synthase HVY54_04465 ENOG4108R8B oxidoreductase Fe-S subunit HVY54_04470 ENOG4105C7N Xanthine uracil vitamin C permease HVY54_04475 ENOG4107QUY Guanine deaminase HVY54_04480 ENOG4105C2W permease HVY54_04485 ENOG4105C7W Xanthine dehydrogenase HVY54_04490 ENOG410873Y FAD binding domain in molybdopterin dehydrogenase HVY54_04495 ENOG4107UUR Chlorohydrolase aminohydrolase HVY54_04500 ENOG4105BZ8 glutamate synthase HVY54_04505 ENOG4105MFX 4-diphosphocytidyl-2c-methyl-d-erythritol synthase HVY54_04510 ENOG4105MJ6 selenium-dependent hydroxylase accessory protein YqeC HVY54_04515 ENOG4107P0T Selenium-dependent molybdenum hydroxylase system protein, YqeB family HVY54_04520 ENOG4105C5B carbamate kinase HVY54_04530 ENOG4107S4Y M20 DapE family protein YgeY HVY54_04535 ENOG4107RCH Diaminopropionate ammonia-lyase HVY54_04540 ENOG4105IW6 Carbamoyltransferase HVY54_04545 ENOG4108JUB Transcriptional regulator HVY54_04550 ENOG4108UTP (2Fe-2S)-binding domain protein HVY54_04555 ENOG4108HR6 Dehydrogenase HVY54_04560 ENOG4105C7W Xanthine dehydrogenase HVY54_04565 ENOG4108K5P (LipO)protein HVY54_04575 ENOG4108T88 HVY54_04585 ENOG41090HZ type iii secretion HVY54_04595 ENOG4108N8R Invasion protein HVY54_04600 ENOG4108HR8 type iii secretion HVY54_04605 ENOG4108JIR Flagellum-specific ATP synthase HVY54_04625 ENOG41075IY surface presentation of antigens protein SpaP HVY54_04630 ENOG4105U07 type iii secretion HVY54_04635 ENOG4108TN6 type iii secretion HVY54_04640 ENOG4108M6W surface presentation of antigens protein SpaS HVY54_04645 ENOG4108M6W surface presentation of antigens protein SpaS HVY54_04660 ENOG4108RC9 Type III secretion system protein HVY54_04665 ENOG4105Y7Q type iii secretion HVY54_04670 ENOG4106BTR HVY54_04675 ENOG4108RBT type iii secretion HVY54_04695 ENOG4105K5T PilT protein HVY54_04705 ENOG4108YAB Invasion protein HVY54_04730 ENOG4105FV3 HVY54_04735 ENOG4108TC1 Transcriptional regulator HVY54_04740 ENOG4105ISV protein with bipartite regulator domain HVY54_04745 ENOG4108MHD transport protein HVY54_04750 ENOG4105CHU acetyl-coa acetyltransferase HVY54_04760 ENOG4105CHR reductase HVY54_04765 ENOG4107QNK )-transporter HVY54_04775 ENOG4105RQF LysR family Transcriptional regulator HVY54_04785 ENOG41060NJ transcriptional regulator HVY54_04800 ENOG4105CPC Aldo Keto reductase HVY54_04805 ENOG4105SUV lipoprotein YgdR HVY54_04810 ENOG4105EE5 Membrane protein terC HVY54_04825 ENOG4108HRM phosphoenolpyruvate--protein phosphotransferase HVY54_04840 ENOG4105IPU prepilin peptidase dependent protein A HVY54_04845 ENOG4105JCS prepilin peptidase dependent protein HVY54_04850 ENOG4105SEN Protein of unknown function (DUF2509) HVY54_04855 ENOG4105RVB Prepilin peptidase dependent protein c HVY54_04860 ENOG4105DSY exodeoxyribonuclease V, gamma HVY54_04865 ENOG4107QXK peptidase HVY54_04870 ENOG4107QKA exodeoxyribonuclease V beta HVY54_04875 ENOG4107QYX exodeoxyribonuclease v alpha HVY54_04880 ENOG4108EKC n-acetylglutamate synthase HVY54_04885 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase HVY54_04905 ENOG4105CA3 membrane-bound lytic murein transglycosylase HVY54_04910 ENOG4105CUZ uba thif-type nad fad binding protein HVY54_04915 ENOG4105P9C Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity) HVY54_04920 ENOG4105C9B Cysteine desulfurase HVY54_04925 ENOG4105M5B (LipO)protein HVY54_04930 ENOG4105ETT transcriptional Regulator, LysR family HVY54_04935 ENOG4105M08 Membrane HVY54_04945 ENOG4107EDW L-fucose operon activator HVY54_04955 ENOG4105CMG Carbohydrate kinase HVY54_04960 ENOG4105EHF Converts the aldose L-fucose into the corresponding ketose L-fuculose (By similarity) HVY54_04965 ENOG4105EDR glucose galactose transporter HVY54_04970 ENOG4107W7X Aldolase HVY54_04975 ENOG4105C0A alcohol dehydrogenase HVY54_04985 ENOG4105EJQ L-serine dehydratase HVY54_04990 ENOG4105C44 Serine transporter HVY54_04995 ENOG4105EWT decarboxylase family HVY54_05010 ENOG4105WP7 tRNA pseudouridine synthase C HVY54_05015 ENOG4105DR9 pseudouridine synthase HVY54_05020 ENOG4105QDK Flavodoxin HVY54_05025 ENOG4105DJB Major Facilitator Superfamily HVY54_05030 ENOG4105EQX glucarate dehydratase HVY54_05035 ENOG4105EQX glucarate dehydratase HVY54_05040 ENOG4105BZU Histidine kinase HVY54_05045 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) HVY54_05050 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) HVY54_05055 ENOG4106A2Z transcriptional regulator antitoxin, MazE HVY54_05060 ENOG4105MZG transcriptional modulator of maze toxin, mazf HVY54_05065 ENOG4105DXN mazG family HVY54_05080 ENOG4105HA9 of methanol dehydrogenase type HVY54_05090 ENOG4105HA9 of methanol dehydrogenase type HVY54_05100 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) HVY54_05105 ENOG4108CWB sugar kinase ygcE HVY54_05110 ENOG4108ITV Inner membrane protein yqcE HVY54_05115 ENOG4105CHR reductase HVY54_05120 ENOG4107R3A FAD linked oxidase domain protein HVY54_05125 ENOG4105C54 Major Facilitator superfamily HVY54_05130 ENOG4106IKH Electron transfer flavoprotein HVY54_05135 ENOG4105YBM electron transfer flavoprotein subunit ygcQ HVY54_05140 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator HVY54_05145 ENOG4105WQV ferredoxin-like protein HVY54_05150 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase HVY54_05155 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase HVY54_05170 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) HVY54_05175 ENOG4107635 Hok Gef family protein HVY54_05190 ENOG4105PWE CRISPR-associated protein cas2 HVY54_05195 ENOG4108MXK alkaline phosphatase isozyme conversion HVY54_05200 ENOG4105C11 sulfate adenylyltransferase), subunit 2 HVY54_05215 ENOG4105N0Z inner membrane protein ygbE HVY54_05250 ENOG4108K5P (LipO)protein HVY54_05255 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HVY54_05265 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase HVY54_05270 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) HVY54_05275 ENOG4105KZM cytoplasmic protein HVY54_05280 ENOG4105MEW serine threonine protein phosphatase HVY54_05295 ENOG4105VXR cytoplasmic protein HVY54_05300 ENOG4108JUA Transcriptional regulator HVY54_05305 ENOG4105C45 hydrogenase expression formation protein (HypE) HVY54_05310 ENOG4105CQS hydrogenase expression formation protein HypD HVY54_05315 ENOG41083WG hydrogenase assembly chaperone HVY54_05320 ENOG4107RSS Hydrogenase accessory protein HypB HVY54_05325 ENOG410816D Probably plays a role in a hydrogenase nickel cofactor insertion step (By similarity) HVY54_05330 ENOG4108VRC Formate hydrogenlyase regulatory protein hycA HVY54_05335 ENOG4108MFN small subunit of hydrogenase-3, iron-sulfur protein (part of formate hydrogenlyase (FHL) complex) HVY54_05340 ENOG4107R30 NADH dehydrogenase HVY54_05345 ENOG4107TDF Formate hydrogenlyase subunit 4 HVY54_05350 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HVY54_05355 ENOG4108RG7 formate hydrogenlyase complex iron-sulfur subunit HVY54_05360 ENOG4105C47 NADH ubiquinone oxidoreductase 20 kda subunit HVY54_05365 ENOG4105I6X formate hydrogenlyase maturation HVY54_05370 ENOG4108MG9 hydrogenase 3 maturation protease HVY54_05380 ENOG4108Z3N Transcriptional regulator HVY54_05385 ENOG4105CS2 ec 3.2.1.21 HVY54_05390 ENOG4105C5Y PTS System HVY54_05395 ENOG4105DDV Transcriptional regulator (LacI family HVY54_05400 ENOG4108RC0 Electron transport protein HVY54_05405 ENOG4105C8H hydrogenase maturation protein Hypf HVY54_05410 ENOG4108EQM faD-dependent pyridine nucleotide-disulfide oxidoreductase HVY54_05425 ENOG4105C2X Arabinose 5-phosphate isomerase HVY54_05430 ENOG410804X Transcriptional regulator HVY54_05435 ENOG4105J92 DNA-binding transcriptional activator GutM HVY54_05440 ENOG4107QMF Sorbitol-6-phosphate dehydrogenase HVY54_05445 ENOG4105VI0 Pts system, glucitol sorbitol-specific HVY54_05455 ENOG410787A Pts system, glucitol sorbitol-specific HVY54_05460 ENOG4105CVE Lytic murein transglycosylase HVY54_05465 ENOG4107TH8 cina domain protein HVY54_05485 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) HVY54_05515 ENOG4107VXZ Hydrolase HVY54_05520 ENOG4105W39 Membrane HVY54_05545 ENOG4105C0R drug resistance transporter emrb qaca subfamily HVY54_05550 ENOG4105CW7 secretion protein, HlyD family HVY54_05555 ENOG4105NTK Transcriptional repressor Mpra HVY54_05560 ENOG4105ZED uncharacterized protein ygaH HVY54_05565 ENOG4108UMN azlc family HVY54_05570 ENOG4105EQ0 Major Facilitator superfamily HVY54_05575 ENOG4105GIJ Glycine betaine HVY54_05580 ENOG4108HQS Glycine betaine HVY54_05585 ENOG4108IJ7 Glycine betaine HVY54_05590 ENOG4107R25 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HVY54_05595 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HVY54_05605 ENOG4105WAZ (Glutaredoxin-like protein) NrdH HVY54_05610 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) HVY54_05620 ENOG4108ZQZ Bacterial protein of unknown function (DUF883) HVY54_05625 ENOG4108WMJ Protein of unknown function (DUF2002) HVY54_05630 ENOG4108RNS Exports L-alanine (By similarity) HVY54_05635 ENOG4108X73 DNA- binding protein HVY54_05640 ENOG4108V62 Rhodanese domain protein HVY54_05645 ENOG41080HT Transcriptional regulator, arsr family HVY54_05650 ENOG4105VPI YqaE family transport protein HVY54_05655 ENOG4109066 lysm domain bon superfamily protein HVY54_05660 ENOG4108PVQ transcriptional regulator HVY54_05665 ENOG4105C85 amino acid HVY54_05670 ENOG4108JPW Aminotransferase HVY54_05675 ENOG4105C26 Dehydrogenase HVY54_05680 ENOG4105D5U fad dependent oxidoreductase HVY54_05690 ENOG4105E54 alpha-amylase HVY54_05715 ENOG4108MGN ATP-binding component of a transport system HVY54_05810 ENOG4105FA0 parb-like partition protein HVY54_05820 ENOG4105DFP Integrase HVY54_05835 ENOG4108Z1B Cyclase dehydrase HVY54_05845 ENOG4105YRI Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) HVY54_05850 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) HVY54_05865 ENOG4108JU6 CBS domain protein HVY54_05870 ENOG4106KVJ cytochrome C assembly protein HVY54_05875 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY HVY54_05900 ENOG41090EK ompa motb domain protein HVY54_05905 ENOG4108KHX Diguanylate cyclase HVY54_05910 ENOG4108WS1 HVY54_05915 ENOG4105QP9 Protein of unknown function (DUF2799) HVY54_05920 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) HVY54_05925 ENOG4105EHE chorismate mutase- prephenate dehydrogenase HVY54_05930 ENOG4105CQC Prephenate dehydratase HVY54_05940 ENOG4108WPH sigma 54 modulation protein ribosomal protein S30EA HVY54_05945 ENOG4105VNT transposase (IS4 family) protein HVY54_05950 ENOG4106SNF Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane HVY54_05955 ENOG4105C34 Pseudouridine synthase HVY54_05960 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase HVY54_05965 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit HVY54_05990 ENOG4105CSH Transporter HVY54_05995 ENOG4105T42 (LipO)protein HVY54_06000 ENOG4105JIM Phosphatidylserine synthase HVY54_06005 ENOG4105CD5 CoA-binding domain protein HVY54_06010 ENOG4106IUH DTW domain containing protein HVY54_06015 ENOG4105K63 Thioredoxin HVY54_06020 ENOG4105EIB trna rrna methyltransferase HVY54_06040 ENOG41090KR LysR family transcriptional Regulator HVY54_06045 ENOG4105C1J atp-dependent rna helicase HVY54_06055 ENOG4108IYU L-aspartate oxidase HVY54_06065 ENOG4105EMN RNA polymerase sigma factor HVY54_06070 ENOG41069PW sigma-e factor negative regulatory protein HVY54_06075 ENOG4105VQK sigma E regulatory protein, MucB RseB HVY54_06080 ENOG4105WMJ Positive regulator of sigma E, RseC MucC HVY54_06090 ENOG4105C3F Signal peptidase i HVY54_06110 ENOG4105CSZ Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity) HVY54_06125 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding HVY54_06130 ENOG4106G6Q Transcriptional regulator HVY54_06135 ENOG4105HYY HAD superfamily (Subfamily IF) hydrolase, YfhB HVY54_06140 ENOG4108Z6B deaminase HVY54_06150 ENOG4108ETH Formylglycinamide ribotide synthetase HVY54_06155 ENOG4107WP9 Histidine kinase HVY54_06160 ENOG4108SKK alpha helix protein HVY54_06165 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family HVY54_06175 ENOG4108EGH Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) HVY54_06185 ENOG4108NZE NAGC-like transcriptional regulator HVY54_06190 ENOG4107HQ7 repeat protein HVY54_06195 ENOG4105FCA ABC transporter periplasmic-binding protein YphF HVY54_06200 ENOG4108F37 ATP-binding component of a transport system HVY54_06205 ENOG4105CNN ABC, transporter HVY54_06210 ENOG4105CPQ Dehydrogenase HVY54_06215 ENOG4108ZKT aldose 1-epimerase HVY54_06220 ENOG4108SB3 DoxX Family HVY54_06245 ENOG4105FUY alpha subunit HVY54_06250 ENOG4108W5M transcriptional regulator HVY54_06255 ENOG4105D8G Major Facilitator superfamily HVY54_06260 ENOG4108MN2 Stationary phase inducible protein CsiE HVY54_06265 ENOG4107XM9 (LipO)protein HVY54_06270 ENOG4105ECY inositol monophosphatase HVY54_06290 ENOG4107XTC May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins HVY54_06310 ENOG4108ZIT Ferredoxin, 2FE-2S HVY54_06315 ENOG4105WVQ Fe-S assembly protein IscX HVY54_06325 ENOG4105YYA enhanced serine sensitivity protein SseB HVY54_06335 ENOG4105KHC sulfurtransferase HVY54_06340 ENOG4105DN3 alpha-2-macroglobulin domain protein HVY54_06345 ENOG4108JQB penicillin-binding protein 1C HVY54_06375 ENOG4105N21 Membrane HVY54_06390 ENOG4105VPD cellular component movement HVY54_06410 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) HVY54_06415 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) HVY54_06450 ENOG41076J9 exonuclease VIII HVY54_06525 ENOG4108TFU terminase (Small subunit) HVY54_06665 ENOG4105NVB glycoside hydrolase, family 19 HVY54_06675 ENOG41066DY Membrane HVY54_06680 ENOG4108ZMA Outer membrane lipoprotein HVY54_06685 ENOG41062G3 Protein of unknown function (DUF2633) HVY54_06695 ENOG4105BZU Histidine kinase HVY54_06700 ENOG4105C9X ppx gppa phosphatase HVY54_06705 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) HVY54_06710 ENOG4108V3E phosphoribosylglycinamide formyltransferase HVY54_06725 ENOG4105C2W permease HVY54_06730 ENOG4108KZ1 Mediates the interaction of DNA replication inititator protein DnaA with DNA polymerase subunit beta sliding clamp (dnaN). Stimulates hydrolysis of ATP-DnaA to ADP-DnaA, rendering DnaA inactive for reinititation, a process called regulatory inhibition of DnaA or RIDA (By similarity) HVY54_06735 ENOG4105K89 arsenate reductase HVY54_06740 ENOG4105ERG peptidase m48, ste24p HVY54_06745 ENOG4105C02 permease HVY54_06750 ENOG4105TMB Formate nitrite transporter HVY54_06755 ENOG4108JUA Transcriptional regulator HVY54_06760 ENOG4105I6X formate hydrogenlyase maturation HVY54_06765 ENOG4105C47 NADH ubiquinone oxidoreductase 20 kda subunit HVY54_06775 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HVY54_06780 ENOG4108JPZ Monovalent cation H antiporter subunit D HVY54_06785 ENOG4107WQX hydrogenase 4 membrane subunit HVY54_06790 ENOG4105D65 subunit l HVY54_06795 ENOG4107TDF Formate hydrogenlyase subunit 4 HVY54_06800 ENOG4108JPZ Monovalent cation H antiporter subunit D HVY54_06805 ENOG4108MFN small subunit of hydrogenase-3, iron-sulfur protein (part of formate hydrogenlyase (FHL) complex) HVY54_06810 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen HVY54_06815 ENOG4105RH4 Glycine cleavage system transcriptional repressor HVY54_06825 ENOG4107EG0 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) HVY54_06835 ENOG4105CGZ zinc metallopeptidase HVY54_06845 ENOG4106KED esterase YpfH HVY54_06860 ENOG4105KUZ arsenate reductase HVY54_06870 ENOG4105BZS acriflavin resistance protein HVY54_06875 ENOG4105BZU Histidine kinase HVY54_06880 ENOG4105BZ8 glutamate synthase HVY54_06890 ENOG4108PVD exported protein HVY54_06895 ENOG4105CV1 Transketolase (EC 2.2.1.1) HVY54_06900 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) HVY54_06905 ENOG4105C6K Malic enzyme HVY54_06910 ENOG4108VJN May be involved in the formation of a specific microcompartment in the cell in which the metabolism of potentially toxic by-products takes place HVY54_06915 ENOG4106S4J ethanolamine utilization protein EutP HVY54_06920 ENOG4105NDK ethanolamine utilization protein HVY54_06925 ENOG4108PFF ethanolamine utilization cobalamin adenosyltransferase HVY54_06930 ENOG4107WUY phosphate acetyltransferase HVY54_06935 ENOG4105KNY Microcompartments protein HVY54_06940 ENOG4105WVM ethanolamine utilization protein EutN carboxysome structural protein Ccml HVY54_06945 ENOG4108EKI Dehydrogenase HVY54_06950 ENOG4107RWI ethanolamine utilization protein eutJ HVY54_06955 ENOG4105C0A alcohol dehydrogenase HVY54_06960 ENOG4105ENY Ethanolamine utilization protein eutH HVY54_06965 ENOG4105DYY Reactivating factor for ethanolamine ammonia lyase HVY54_06970 ENOG4105CPD ethanolamine ammonia-lyase HVY54_06980 ENOG4106D67 ethanolamine utilization protein HVY54_06985 ENOG4108X49 Ethanolamine utilization protein EutK HVY54_06990 ENOG4108K3Z AraC family transcriptional regulator HVY54_07000 ENOG4108KNB n-acetylmuramoyl-l-alanine amidase HVY54_07010 ENOG4105QZU Inner membrane protein YfeZ HVY54_07015 ENOG4105E7K (LipO)protein HVY54_07020 ENOG4105EZR dyp-type peroxidase family protein HVY54_07025 ENOG4107QK9 Beta-lactamase HVY54_07030 ENOG4105C5Y PTS System HVY54_07045 ENOG4105I7Z Short-chain dehydrogenase reductase Sdr HVY54_07050 ENOG4108J2H Sulfate ABC transporter periplasmic sulfate-binding protein HVY54_07055 ENOG4108I5D sulfate abc transporter HVY54_07060 ENOG4105ECW sulfate abc transporter HVY54_07065 ENOG4108IJ6 ABC transporter HVY54_07070 ENOG4105C6T cysteine synthase HVY54_07075 ENOG4105M0Y HVY54_07085 ENOG4105VNT transposase (IS4 family) protein HVY54_07090 ENOG4105C5Y PTS System HVY54_07095 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) HVY54_07105 ENOG4105C6T cysteine synthase HVY54_07125 ENOG4105VRT cytoplasmic protein HVY54_07130 ENOG4105DHU Bile acid HVY54_07135 ENOG4108M0I Transcriptional regulator HVY54_07170 ENOG4105GXM Putative transcription regulator (DUF1323) HVY54_07175 ENOG4105HZG regulatoR HVY54_07190 ENOG4108KMM Diguanylate cyclase HVY54_07195 ENOG4105D9N nucleoside HVY54_07205 ENOG4109076 Conserved Protein HVY54_07210 ENOG4105VCT ion-transport protein YfeO HVY54_07220 ENOG4105R6B The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane (By similarity) HVY54_07225 ENOG410863U PTS System HVY54_07230 ENOG4105DC7 peptidase M24 HVY54_07235 ENOG4105CN9 Peptidase m42 family protein HVY54_07240 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) HVY54_07245 ENOG4108CIP transcriptional regulator HVY54_07250 ENOG4105DY9 regulatoR HVY54_07255 ENOG4108HRK Histidine kinase HVY54_07260 ENOG4105CHM Aminotransferase HVY54_07270 ENOG4105D1S lipid A biosynthesis HVY54_07275 ENOG4105W9M Membrane HVY54_07285 ENOG4108V08 YfdX protein HVY54_07295 ENOG4105CFN oxalyl-CoA decarboxylase HVY54_07300 ENOG4108N2Y auxin Efflux HVY54_07305 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F HVY54_07310 ENOG4105BZU Histidine kinase HVY54_07315 ENOG4108WQH regulatoR HVY54_07320 ENOG4105CW7 secretion protein, HlyD family HVY54_07325 ENOG4105C0R drug resistance transporter emrb qaca subfamily HVY54_07340 ENOG4106NDP Transcriptional regulator HVY54_07345 ENOG4108HKT sucrose-6-phosphate hydrolase HVY54_07350 ENOG4105D7K pfkb domain protein HVY54_07355 ENOG4105U0F oligosaccharide H symporter, major facilitator superfamily (MFS) HVY54_07370 ENOG4105S64 Formate nitrite transporter HVY54_07375 ENOG410903C (LipO)protein HVY54_07385 ENOG4105CKF membrane protein involved in aromatic hydrocarbon degradation HVY54_07390 ENOG4105KZW UPF0381 protein HVY54_07405 ENOG4108BY2 phosphohistidine phosphatase HVY54_07415 ENOG4106PG1 outer membrane usher protein HVY54_07420 ENOG4108FZ9 Chaperone HVY54_07425 ENOG4105NEV Fimbrial HVY54_07430 ENOG4105UGQ Fimbrial HVY54_07435 ENOG4105US4 fimbrial-like protein yfcP HVY54_07450 ENOG4105C76 Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity) HVY54_07455 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase HVY54_07465 ENOG4105EJ9 Membrane HVY54_07470 ENOG4108BPE -transporting atpase HVY54_07475 ENOG4105MH2 YfcL protein HVY54_07480 ENOG4105CWG Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity) HVY54_07485 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) HVY54_07490 ENOG4105F9N Major Facilitator Superfamily HVY54_07495 ENOG4106WZ1 flagella biosynthesis regulator HVY54_07500 ENOG4105YB8 TM2 domain containing protein HVY54_07555 ENOG4108C33 Resolvase HVY54_07590 ENOG4105ED4 portal protein HVY54_07605 ENOG4105VZ1 Replication Protein HVY54_07675 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HVY54_07685 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) HVY54_07695 ENOG4105DQR SNARE associated Golgi HVY54_07705 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase HVY54_07710 ENOG4108S3P Sporulation domain protein HVY54_07715 ENOG4105E96 Colicin v production protein HVY54_07720 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase HVY54_07725 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase HVY54_07730 ENOG4105E89 ABC transporter HVY54_07735 ENOG4105E89 ABC transporter HVY54_07740 ENOG4105DSP amino acid AbC transporter HVY54_07745 ENOG4106YG3 ABC transporter HVY54_07750 ENOG4108JEH abc transporter atp-binding protein HVY54_07755 ENOG4105DNE Transposase HVY54_07760 ENOG4105ECP epimerase HVY54_07765 ENOG4105KKP D-erythro-7,8-dihydroneopterin triphosphate 2'-epimerase HVY54_07770 ENOG4105CYM Glutathione S-transferase HVY54_07775 ENOG4108SHQ Glutathione S-transferase HVY54_07780 ENOG4108RE9 Phosphodiesterase HVY54_07785 ENOG4105PTV Nudix Hydrolase HVY54_07790 ENOG4105CSX c4-dicarboxylate anaerobic carrier HVY54_07795 ENOG4105C6K Malic enzyme HVY54_07800 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) HVY54_07810 ENOG4105XWI UPF0304 protein HVY54_07815 ENOG4105EVE HAD-superfamily hydrolase subfamily IA variant 3 HVY54_07820 ENOG4107QWE )-transporter HVY54_07830 ENOG4105CHM Aminotransferase HVY54_07835 ENOG4107NQ8 LysR family Transcriptional regulator HVY54_07855 ENOG4105GKE subunit e HVY54_07860 ENOG4107QIZ NADH dehydrogenase HVY54_07865 ENOG4108IEH NADH dehydrogenase subunit g HVY54_07880 ENOG4107UFS subunit j HVY54_07890 ENOG4105D65 subunit l HVY54_07895 ENOG4105C8S subunit m HVY54_07905 ENOG4105GDX Domain of unknown function (DUF1877) HVY54_07925 ENOG4107YB6 acetyltransferase, (GNAT) family HVY54_07930 ENOG4105TNS Conserved Protein HVY54_07935 ENOG4105E4F Isochorismate synthase HVY54_07950 ENOG4108IPT Naphthoate synthase HVY54_07960 ENOG4105CEY Amp-dependent synthetase and ligase HVY54_07965 ENOG4106GZG polymyxin resistance protein B HVY54_07970 ENOG4105U65 Translocates 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol (alpha-L-Ara4N-phosphoundecaprenol) from the cytoplasmic to the periplasmic side of the inner membrane (By similarity) HVY54_08015 ENOG4108UII YfaZ family HVY54_08020 ENOG4108EWA cinA-like protein HVY54_08025 ENOG4107258 Transcriptional regulator HVY54_08035 ENOG4105CSP Major Facilitator Superfamily HVY54_08040 ENOG4105CNV Aldolase HVY54_08050 ENOG4105DNE Transposase HVY54_08055 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) HVY54_08065 ENOG4107R5Y anaerobic glycerol-3-phosphate dehydrogenase, subunit A HVY54_08070 ENOG4105CXY transporter HVY54_08075 ENOG4106MZZ glycerophosphoryl diester phosphodiesterase HVY54_08080 ENOG4105GZI Transcriptional regulator HVY54_08085 ENOG4105CZM Major Facilitator HVY54_08090 ENOG4105FQR PH-inducible protein involved in stress response HVY54_08095 ENOG4105XPH Ferredoxin HVY54_08100 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HVY54_08105 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HVY54_08110 ENOG4107GHC outer membrane autotransporter HVY54_08120 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HVY54_08125 ENOG4107FKF Uncharacterized protein conserved in bacteria (DUF2138) HVY54_08130 ENOG4108QJJ Protein of unknown function (DUF1175) HVY54_08135 ENOG4107S52 alpha-2-macroglobulin domain protein HVY54_08140 ENOG41081SK signal peptide protein HVY54_08145 ENOG4105EDV vault protein HVY54_08150 ENOG4105CHU acetyl-coa acetyltransferase HVY54_08155 ENOG4105CRW Short chain fatty acid transporter HVY54_08160 ENOG4107QNJ CoA-transferase subunit B HVY54_08165 ENOG4107QP7 CoA-transferase subunit A HVY54_08170 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family HVY54_08175 ENOG4105BZU Histidine kinase HVY54_08180 ENOG4105BZU Histidine kinase HVY54_08185 ENOG41068CG regulatoR HVY54_08190 ENOG4105E3G Phosphotransfer intermediate protein in two-component regulatory system with RcsBC HVY54_08195 ENOG4105FCK Membrane HVY54_08200 ENOG4105CJ2 (LipO)protein HVY54_08205 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) HVY54_08210 ENOG4105CF1 Alkylated DNA repair protein HVY54_08215 ENOG4105IBP Cyclic peptide transporter HVY54_08235 ENOG4108ZNS ferredoxin-type protein NapF HVY54_08240 ENOG41061Q0 Assembly protein for periplasmic nitrate reductase HVY54_08250 ENOG4108BGM Quinol dehydrogenase periplasmic component HVY54_08255 ENOG4105GXZ Ferredoxin-type protein NapH HVY54_08260 ENOG4108ZMS Electron transfer subunit of the periplasmic nitrate reductase complex NapAB (By similarity) HVY54_08265 ENOG4105CUW cytochrome C-TYPE protein HVY54_08270 ENOG4107EV4 once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system (By similarity) HVY54_08275 ENOG4105CA5 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes (By similarity) HVY54_08280 ENOG41060IM Heme exporter protein HVY54_08285 ENOG4105X3C heme exporter protein HVY54_08295 ENOG4105DA4 cytochrome c-type biogenesis protein HVY54_08300 ENOG4107QX9 Thiol disulfide interChange protein HVY54_08305 ENOG4105KWW Biogenesis protein HVY54_08310 ENOG4105WH1 Two component transcriptional regulator luxr family HVY54_08315 ENOG4108MGN ATP-binding component of a transport system HVY54_08325 ENOG4105E68 Sulfatase HVY54_08345 ENOG4105CFI type iii restriction protein res subunit HVY54_08350 ENOG4105I08 Pseudouridine synthase HVY54_08355 ENOG4105C2C drug resistance transporter, Bcr CflA HVY54_08360 ENOG4105HG6 HVY54_08365 ENOG4108JQ5 ABC transporter HVY54_08370 ENOG4108IYQ Binding-protein-dependent transport systems inner membrane component HVY54_08375 ENOG4108I5X binding-protein-dependent transport systems inner membrane Component HVY54_08380 ENOG4105E43 Extracellular solute-binding protein, family 5 HVY54_08385 ENOG4105CXC rtn protein HVY54_08390 ENOG4107TT5 NLP P60 protein HVY54_08395 ENOG41076MN Phosphoesterase, PA-phosphatase related HVY54_08400 ENOG4105CKI cobalamin synthesis protein HVY54_08405 ENOG4105DEI Mannitol dehydrogenase HVY54_08415 ENOG4105KRS Proteinase inhibitor HVY54_08420 ENOG4105S8Q sugar efflux transporter HVY54_08425 ENOG4105DTZ bifunctional PTS system fructose-specific transporter subunit IIA HPr protein HVY54_08430 ENOG4105DE4 1-phosphofructokinase HVY54_08435 ENOG4105DM4 PTS System HVY54_08440 ENOG4105DD7 kinase (PfkB family HVY54_08445 ENOG4105D53 Catalyzes the hydrolysis of pseudouridine 5'-phosphate (PsiMP) to ribose 5-phosphate and uracil (By similarity) HVY54_08450 ENOG4105D9N nucleoside HVY54_08455 ENOG4108Y4K DNA-binding transcriptional activator HVY54_08465 ENOG4105D9N nucleoside HVY54_08470 ENOG4105DD7 kinase (PfkB family HVY54_08480 ENOG4105HMI Membrane HVY54_08485 ENOG4105DUM transcriptional regulator, lysR family HVY54_08490 ENOG4108IQI permease HVY54_08495 ENOG4105D05 Receptor HVY54_08500 ENOG4105C4W S-formylglutathione hydrolase HVY54_08510 ENOG4105DHF Membrane HVY54_08515 ENOG41060NJ transcriptional regulator HVY54_08520 ENOG4105EMA Periplasmic binding protein LacI transcriptional regulator HVY54_08525 ENOG4105C2J ABC transporter HVY54_08530 ENOG4108HWV )-transporter HVY54_08535 ENOG4107SJI Dehydrogenase HVY54_08540 ENOG4105BZ8 glutamate synthase HVY54_08545 ENOG4105Y9N Membrane HVY54_08550 ENOG4107GZ4 SanA protein HVY54_08560 ENOG41067MG lrgb family HVY54_08590 ENOG4108RXX maleylacetoacetate isomerase HVY54_08595 ENOG4105MSY salicylate hydroxylase HVY54_08600 ENOG4105FBT Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity) HVY54_08610 ENOG4105ETP RND efflux system, outer membrane lipoprotein HVY54_08615 ENOG4105H9W Short-chain dehydrogenase reductase Sdr HVY54_08620 ENOG4105KHU inner membrane protein YohD HVY54_08625 ENOG41069YE inner membrane protein yohC HVY54_08630 ENOG41061WM D-Alanyl-D-Alanine HVY54_08635 ENOG4105CXG d-lactate dehydrogenase HVY54_08640 ENOG4107QK4 glycoside hydrolase, family 3 domain protein HVY54_08645 ENOG4107SI7 Substrate-binding region of abc-type glycine betaine transport system HVY54_08650 ENOG4107T5X Binding-protein-dependent transport systems, inner membrane component HVY54_08655 ENOG4108IJ8 ABC transporter HVY54_08660 ENOG4105WJV Binding-protein-dependent transport systems, inner membrane component HVY54_08670 ENOG4108XDN Transcriptional regulator HVY54_08675 ENOG4108HRK Histidine kinase HVY54_08680 ENOG4108NEV two component transcriptional regulator, LytTR family HVY54_08685 ENOG4108W15 Protein of unknown function (DUF1456) HVY54_08690 ENOG4108YCW (LipO)protein HVY54_08695 ENOG410903U zinc ion binding HVY54_08700 ENOG4105DEG Vwa containing coxe family protein HVY54_08705 ENOG4105RD5 HVY54_08710 ENOG4105KKX ATPase associated with various cellular activities aaa_5 HVY54_08730 ENOG4108KDT Molybdate metabolism regulator HVY54_08740 ENOG4105D1F ATP-binding protein HVY54_08745 ENOG41067AK Protein of unknown function (DUF2574) HVY54_08750 ENOG41063W2 Fimbrial protein HVY54_08755 ENOG4108MQF Chaperone HVY54_08765 ENOG410662B Type-1 fimbrial protein HVY54_08770 ENOG4108Z1S Influences nickel and cobalt homeostasis. May act by modulating RcnA-mediated export of these ions to avoid excess efflux. Not involved in nickel import and does not bind nickel or cobalt ions directly HVY54_08790 ENOG4105DWF phosphomethylpyrimidine kinase HVY54_08795 ENOG4108UQ1 hydrolase, family 25 HVY54_08800 ENOG4105FDP GntR family transcriptional regulator HVY54_08805 ENOG4108TFM Kinase, PfkB family HVY54_08810 ENOG4108KD5 ADP-ribosylation crystallin J1 HVY54_08815 ENOG4105EAA nucleoside HVY54_08820 ENOG4105EIE fructose-bisphosphate aldolase HVY54_08835 ENOG41082GB PTS system galactitol-specific transporter subunit IIA HVY54_08840 ENOG41090UW PTS System HVY54_08845 ENOG4105DT3 PTS system, galactitol-specific IIc component HVY54_08850 ENOG4107WTH Galactitol-1-phosphate dehydrogenase HVY54_08865 ENOG41076Z6 Uncharacterized protein yegR HVY54_08870 ENOG4105CFP Peptidase U32 HVY54_08875 ENOG4105KWI UPF0339 protein HVY54_08880 ENOG4105E3W Two component transcriptional regulator (Winged helix family HVY54_08885 ENOG4105EB3 Histidine kinase HVY54_08895 ENOG4105BZS acriflavin resistance protein HVY54_08925 ENOG4108M24 von Willebrand factor, type A HVY54_08930 ENOG4105UM3 Inherit from NOG: serine threonine phosphoprotein phosphatase HVY54_08935 ENOG4106E1W protein with protein kinase and helix-hairpin-helix DNA-binding HVY54_08940 ENOG4105R8A Heat shock protein HVY54_08945 ENOG4105D03 DNA-3-methyladenine glycosylase II HVY54_08950 ENOG4105BZU Histidine kinase HVY54_08955 ENOG4105DBI uridine monophosphokinase HVY54_08965 ENOG4108GAE asmA family HVY54_08970 ENOG4105EE5 Membrane protein terC HVY54_08975 ENOG4105DAY polysaccharide export protein HVY54_08980 ENOG4105KJF protein tyrosine phosphatase HVY54_08985 ENOG4105D75 Capsular exopolysaccharide family HVY54_08990 ENOG41090RK glycosyl transferase HVY54_08995 ENOG41068PY Colanic acid biosynthesis acetyltransferase wcaB HVY54_09000 ENOG4107RXY Glycosyl transferase HVY54_09005 ENOG4108NYJ Colanic acid HVY54_09010 ENOG4105ECJ Glycosyl Transferase HVY54_09015 ENOG4108Z90 colanic acid biosynthesis acetyltransferase wcaF HVY54_09020 ENOG4105C0K Gdp-mannose 4,6-dehydratase HVY54_09025 ENOG4105C30 Nad-dependent epimerase dehydratase HVY54_09030 ENOG4105FGF GDP-mannose mannosyl hydrolase HVY54_09035 ENOG4106CD9 glycosyl transferase group 1 HVY54_09040 ENOG4105CJT Mannose-1-phosphate guanylyltransferase HVY54_09045 ENOG4107QKV phosphomannomutase HVY54_09050 ENOG4105D3Q Sugar transferase HVY54_09055 ENOG4105PSV Polysaccharide Biosynthesis Protein HVY54_09060 ENOG4105C74 pyruvyl transferase HVY54_09065 ENOG4107T8Q Glycosyl transferase (Group 1 HVY54_09070 ENOG4105G1A colanic acid biosynthesis protein HVY54_09075 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase HVY54_09080 ENOG4105C1B dTDP-glucose 4-6-dehydratase HVY54_09085 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase HVY54_09090 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) HVY54_09095 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase HVY54_09115 ENOG4105K64 Glycosyl transferase, family 2 HVY54_09125 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) HVY54_09130 ENOG4105C6Y Udp-glucose 6-dehydrogenase HVY54_09155 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) HVY54_09160 ENOG4105ECC imidazole-glycerol-phosphate dehydratase HVY54_09165 ENOG4105CIH Imidazole acetol-phosphate transaminase HVY54_09170 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) HVY54_09185 ENOG4105VTW prevent-host-death family HVY54_09190 ENOG4105KRQ Addiction module toxin, Txe YoeB family HVY54_09195 ENOG4107SRH Nad-dependent epimerase dehydratase HVY54_09200 ENOG4105EQ1 Transcriptional regulator HVY54_09210 ENOG4105CUB amino acid HVY54_09215 ENOG4105CUC YeeE YedE family protein HVY54_09225 ENOG4105CJB Exodeoxyribonuclease I HVY54_09230 ENOG4105DZ1 carboxypeptidase HVY54_09240 ENOG4105DR8 Membrane HVY54_09275 ENOG4105MAW Antitoxin component of a toxin-antitoxin (TA) module. Labile antitoxin that counteracts the effect of the CbtA (YeeV) toxin. It does not bind to the cognate toxin but instead binds to MreB and FtsZ (the toxin targets), enhancing their polymerization by forming higher-order bundles HVY54_09285 ENOG4108YGG dna repair protein HVY54_09290 ENOG4105MFG Antirestriction protein HVY54_09330 ENOG41080QX K07048 phosphotriesterase-related protein HVY54_09360 ENOG4108YZT Adenosylcobinamide kinase HVY54_09365 ENOG4108UHF Joins Ado-cobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin) (By similarity) HVY54_09375 ENOG4108PXI ErfK YbiS YcfS YnhG HVY54_09385 ENOG4106P55 Transcriptional regulator HVY54_09390 ENOG4107R11 Transcriptional regulator HVY54_09400 ENOG4105UQX Mate efflux family protein HVY54_09410 ENOG4105CDY transcriptional regulatory protein HVY54_09415 ENOG4105FYV Amp nucleosidase HVY54_09420 ENOG4105CSH Transporter HVY54_09430 ENOG4105TNG K13735 adhesin invasin HVY54_09440 ENOG4105EXZ Involved in the regulation of ptsG expression by binding and inactivating Mlc (By similarity) HVY54_09450 ENOG4108VKM cytochrome b561 HVY54_09455 ENOG4108MEK Metal-binding protein YodA HVY54_09460 ENOG4105DQ2 Is probably involved in the electron transfer between its heme and the molybdenum cofactor of the reductase catalytic subunit YedY (By similarity) HVY54_09470 ENOG4105VT2 5-hydroxyisourate hydrolase HVY54_09475 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HVY54_09480 ENOG4107ZY3 Histidine kinase HVY54_09485 ENOG4105TMR Functions as a holding molecular chaperone (holdase) which stabilizes unfolding intermediates and rapidly releases them in an active form once stress has abated. Plays an important role in protecting cells from severe heat shock and starvation, as well as in acid resistance of stationary-phase cells. It catalyzes the conversion of methylglyoxal (MG) to D-lactate in a single glutathione (GSH)-independent step (By similarity) HVY54_09490 ENOG4105FCK Membrane HVY54_09495 ENOG4105Y0K Inner membrane protein YedR HVY54_09500 ENOG4105EST Metal Dependent Phosphohydrolase HVY54_09505 ENOG4105DVF Cytosine-specific methyltransferase HVY54_09510 ENOG41090BB DNA mismatch endonuclease (vsr) HVY54_09515 ENOG4105FDR Membrane HVY54_09520 ENOG4105CKW Inner membrane protein yedI HVY54_09525 ENOG4105VNZ cytoplasmic protein HVY54_09530 ENOG4105BZU Histidine kinase HVY54_09540 ENOG4105YX3 cellular response to acidity HVY54_09550 ENOG4107TKS colanic acid capsular biosynthesis activation protein A HVY54_09555 ENOG4105D19 Role in flagellar biosynthesis (By similarity) HVY54_09565 ENOG4105CN7 Flagellar biosynthetic protein FliP HVY54_09570 ENOG4105K0P flagellar biosynthesis protein HVY54_09575 ENOG4105DD5 Flagellar motor switch protein HVY54_09580 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) HVY54_09585 ENOG4107ZI8 flagellar basal body-associated protein flil HVY54_09590 ENOG4105WF4 Flagellar hook-length control protein HVY54_09595 ENOG4105GSA Flagellar export protein flij HVY54_09600 ENOG4108JIR Flagellum-specific ATP synthase HVY54_09605 ENOG41090PJ Flagellar assembly protein HVY54_09610 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) HVY54_09615 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) HVY54_09630 ENOG4108RAV Conserved protein HVY54_09640 ENOG41066VF YeeE YedE family protein HVY54_09645 ENOG4108W9D (LipO)protein HVY54_09650 ENOG4105E5K Alpha-amylase HVY54_09660 ENOG4105MQ3 flagellar protein FliS HVY54_09665 ENOG4105DTS flagellar hook-associated HVY54_09670 ENOG4105I03 Flagellin HVY54_09675 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HVY54_09680 ENOG4108M9K flagella biosynthesis protein FliZ HVY54_09685 ENOG4105EAB amino acid AbC transporter HVY54_09690 ENOG4105K6H D-cysteine desulfhydrase HVY54_09695 ENOG4105E5Q amino acid AbC transporter HVY54_09700 ENOG4105CDA abc transporter atp-binding protein HVY54_09705 ENOG4105VJY transcriptional regulator HVY54_09710 ENOG4105XVG cytoplasmic protein HVY54_09720 ENOG4105WH1 Two component transcriptional regulator luxr family HVY54_09750 ENOG4106RHG Yeca family HVY54_09755 ENOG4105E0U tyrosine-specific transport protein HVY54_09760 ENOG4105VVZ metal-binding protein HVY54_09765 ENOG41090A1 ferritin HVY54_09770 ENOG4105P23 (LipO)protein HVY54_09780 ENOG4105N4N Protein of unknown function (DUF2766) HVY54_09785 ENOG4108UEC Ferritin-like protein HVY54_09790 ENOG4105DMK Periplasmic binding protein LacI transcriptional regulator HVY54_09795 ENOG4105C2J ABC transporter HVY54_09800 ENOG4105CNN ABC, transporter HVY54_09805 ENOG4108K4C ec 3.1.3.12 HVY54_09815 ENOG4108VA4 Universal stress protein HVY54_09825 ENOG4106CIA Functions in complex with FlhD as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region HVY54_09830 ENOG4107RD7 Flagellar Motor Protein, MotA HVY54_09835 ENOG4105ER2 Ompa motb domain protein HVY54_09840 ENOG4105CBS Chea signal transduction histidine kinase HVY54_09845 ENOG4108V3W Chemotaxis protein, CheW HVY54_09850 ENOG4105C8Q Methyl-accepting chemotaxis HVY54_09855 ENOG4105C8Q Methyl-accepting chemotaxis HVY54_09860 ENOG4105BZU Histidine kinase HVY54_09870 ENOG4108VYJ response regulator receiver protein HVY54_09875 ENOG4108KCC Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P) (By similarity) HVY54_09880 ENOG4105D00 flagellar biosynthetic protein flhB HVY54_09885 ENOG4105D7B Flagellar biosynthesis protein flha HVY54_09890 ENOG4105W13 flagellar protein HVY54_09900 ENOG4105C75 arginyL-tRNA synthetase HVY54_09905 ENOG4106ZCM YecM protein HVY54_09915 ENOG4105CUW cytochrome C-TYPE protein HVY54_09920 ENOG4108J2R molybdopterin oxidoreductase HVY54_09935 ENOG4105WJG Glutathione HVY54_09940 ENOG41081XQ Conserved Protein HVY54_09945 ENOG4105D3W isochorismatase HVY54_09955 ENOG4108TIT dATP pyrophosphohydrolase HVY54_09960 ENOG4105CDY transcriptional regulatory protein HVY54_09970 ENOG4107S01 Repressor protein MetJ HVY54_09990 ENOG4105FAV ABC, transporter HVY54_10000 ENOG4105NXV High-affinity zinc uptake system protein HVY54_10005 ENOG4105DR5 peptidase HVY54_10010 ENOG4105NWR lipid A biosynthesis (Kdo)2-(Lauroyl)-lipid IVA acyltransferase HVY54_10015 ENOG4105CA9 Pyruvate kinase HVY54_10020 ENOG4106KNT transcriptional regulator HVY54_10025 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase HVY54_10030 ENOG4105C01 Dihydroxy-acid dehydratase HVY54_10035 ENOG4108UHU Aldolase HVY54_10045 ENOG4105X2V dna damage-inducible protein HVY54_10055 ENOG4108Q2J Inner membrane protein YebE HVY54_10060 ENOG4105CUG Oligopeptidase b HVY54_10065 ENOG4105UMD exodeoxyribonuclease X HVY54_10070 ENOG4108YGA nitrilase cyanide hydratase and apolipoprotein n-acyltransferase HVY54_10075 ENOG4105MPK DNA polymerase III subunit theta HVY54_10080 ENOG4105FXM Copper resistance protein HVY54_10085 ENOG4108PNC copper resistance HVY54_10090 ENOG4105NKT exported protein HVY54_10095 ENOG4108R1E Serine threonine protein phosphatase 1 HVY54_10100 ENOG4105UVW uncharacterized protein yebW HVY54_10105 ENOG4105WT8 Protein of unknown function (DUF1480) HVY54_10115 ENOG4105DY2 Paraquat-inducible protein b HVY54_10120 ENOG4105H2K paraquat-inducible protein a HVY54_10125 ENOG4108ZGC gaf domain protein HVY54_10135 ENOG4105CN1 protease HVY54_10145 ENOG4105C0R drug resistance transporter emrb qaca subfamily HVY54_10150 ENOG4105J4Q Transcriptional regulator HVY54_10155 ENOG4105TIK HVY54_10165 ENOG4105Q3Y exported protein HVY54_10180 ENOG4105DHI Methyltransferase HVY54_10195 ENOG4105F3R pts system mannose fructose sorbose family iid HVY54_10200 ENOG4105ETZ PTS System HVY54_10205 ENOG4105DAS pts system HVY54_10210 ENOG4105EE5 Membrane protein terC HVY54_10215 ENOG4107XTP (EAL) domain protein HVY54_10220 ENOG4105EJQ L-serine dehydratase HVY54_10230 ENOG4105CRQ synthase (Component I) HVY54_10240 ENOG4105V2F Uncharacterized protein yoac HVY54_10245 ENOG4105M4H endoribonuclease L-psp HVY54_10250 ENOG4105DVT helicase HVY54_10255 ENOG41072GX Peptidase M22 Glycoprotease HVY54_10260 ENOG4105Y4Z Outer Membrane Lipoprotein HVY54_10265 ENOG4105CEY Amp-dependent synthetase and ligase HVY54_10270 ENOG4105ZIE Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity) HVY54_10275 ENOG4105E3J oxidoreductase HVY54_10280 ENOG4105DVW rieske (2Fe-2S) HVY54_10285 ENOG4105C94 Transporter HVY54_10295 ENOG4105EJC lysr family transcriptional regulator HVY54_10305 ENOG4108YS1 cytoplasmic protein HVY54_10310 ENOG4105YP6 Domain of unknown function (DUF1869) HVY54_10315 ENOG4105Y3U Transglycosylase-associated protein HVY54_10325 ENOG4106G4W HVY54_10330 ENOG410620I Diguanylate cyclase HVY54_10335 ENOG4105UCG Domain of unknown function (DUF333) HVY54_10340 ENOG4105K78 MarR family Transcriptional regulator HVY54_10345 ENOG4105DJ2 Major Facilitator Superfamily HVY54_10350 ENOG4105R1U AraC Family Transcriptional Regulator HVY54_10365 ENOG4108KXH Ybak prolyl-tRNA synthetase associated HVY54_10370 ENOG4108KHP Diguanylate cyclase HVY54_10375 ENOG4106KTS Inner membrane protein yeaI HVY54_10385 ENOG4105CYN Serine protein kinase HVY54_10390 ENOG4105GNX MltA-interacting MipA family protein HVY54_10395 ENOG4105CV8 reductase HVY54_10400 ENOG4105DSB aldose 1-epimerase HVY54_10405 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase HVY54_10415 ENOG4105VUT cytoplasmic protein HVY54_10420 ENOG4105CPQ Dehydrogenase HVY54_10425 ENOG4107TE1 transport protein HVY54_10430 ENOG4105CPQ Dehydrogenase HVY54_10435 ENOG4105D2N Aldolase HVY54_10440 ENOG4107UH8 sugar kinase HVY54_10445 ENOG4105CPC Aldo Keto reductase HVY54_10450 ENOG4105E98 transcriptional regulator DeoR family HVY54_10455 ENOG4108KUU Inner membrane metabolite transport protein ydjE HVY54_10460 ENOG4108RWI nicotinamidase HVY54_10465 ENOG4105HDK L-asparaginase HVY54_10470 ENOG4105D07 Signal peptide peptidase, SppA HVY54_10475 ENOG41069NU Nitroreductase HVY54_10480 ENOG4105D4F Synthesizes selenophosphate from selenide and ATP (By similarity) HVY54_10485 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) HVY54_10490 ENOG41065FB inner membrane protein ynji HVY54_10495 ENOG4105D82 Glutamate dehydrogenase HVY54_10500 ENOG4105MTM Protein of unknown function (DUF1496) HVY54_10505 ENOG4105M6F mutator MutT protein HVY54_10510 ENOG4108T9J Cdp-alcohol phosphatidyltransferase HVY54_10515 ENOG4107RM6 sulfurtransferase HVY54_10520 ENOG4108VGW abc transporter atp-binding protein HVY54_10525 ENOG4105CXZ ABC transporter, permease HVY54_10530 ENOG4105VNH ABC transporter solute-binding protein HVY54_10535 ENOG4107ZN8 Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) HVY54_10540 ENOG4108N5C SNARE associated Golgi protein-related protein HVY54_10545 ENOG4108KCW iron-sulfur cluster binding HVY54_10550 ENOG4108RSN SNARE associated Golgi HVY54_10555 ENOG4105CGK Exodeoxyribonuclease III HVY54_10570 ENOG4105C26 Dehydrogenase HVY54_10585 ENOG4108SPG Periplasmic Protein HVY54_10595 ENOG4105DKD Incises the DNA at the 3' side of a lesion during nucleotide excision repair. Incises the DNA farther away from the lesion than UvrC. Not able to incise the 5' site of a lesion. When a lesion remains because UvrC is not able to induce the 3' incision, Cho incises the DNA. Then UvrC makes the 5' incision. The combined action of Cho and UvrC broadens the substrate range of nucleotide excision repair (By similarity) HVY54_10605 ENOG4105KKI DNA-binding transcriptional activator OsmE HVY54_10610 ENOG4105VZJ PTS System HVY54_10615 ENOG4105CK1 PTS System HVY54_10620 ENOG4105VCP PTS System HVY54_10625 ENOG4105EZV Transcriptional regulator HVY54_10630 ENOG4105F8D glycoside hydrolase family 4 HVY54_10640 ENOG4105CH6 catalase HVY54_10655 ENOG4108ETY sodium dicarboxylate symporter HVY54_10660 ENOG4107K5X Membrane-bound metal-dependent hydrolase HVY54_10665 ENOG4107UW8 HAD-superfamily hydrolase subfamily IA variant 3 HVY54_10670 ENOG4107PN8 YfeABCD locus regulator HVY54_10680 ENOG4105P10 Uncharacterized protein ydiZ HVY54_10685 ENOG4105DE4 1-phosphofructokinase HVY54_10690 ENOG4108NE3 Salt-induced outer membrane protein HVY54_10710 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) HVY54_10715 ENOG41082NX 50s ribosomal protein l35 HVY54_10830 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HVY54_10850 ENOG4108V06 Glutathione peroxidase HVY54_10860 ENOG4108QBX (LipO)protein HVY54_10865 ENOG4108TC0 Diguanylate phosphodiesterase HVY54_10880 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) HVY54_10890 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) HVY54_10895 ENOG4105CEY Amp-dependent synthetase and ligase HVY54_10900 ENOG41090P5 ferredoxin-like protein HVY54_10905 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase HVY54_10910 ENOG4105C10 Electron transfer flavoprotein HVY54_10915 ENOG4105CV7 Electron transfer flavoprotein HVY54_10925 ENOG4105C1G acyl-Coa dehydrogenase HVY54_10930 ENOG4108IIG CoA transferase having broad substrate specificity for short-chain acyl-CoA thioesters with the activity decreasing when the length of the carboxylic acid chain exceeds four carbons (By similarity) HVY54_10945 ENOG4105EMV Major Facilitator HVY54_10950 ENOG4105EMV Major Facilitator HVY54_10955 ENOG4105SUA Ydil protein HVY54_10965 ENOG4105IPI Membrane HVY54_10970 ENOG4105CQB FAD linked oxidase domain protein HVY54_10975 ENOG4105KA0 thioesterase Superfamily protein HVY54_10980 ENOG410671Z uncharacterized protein ydiH HVY54_10985 ENOG4108Z4V iron-sulfur cluster assembly HVY54_10990 ENOG4105DIW FeS assembly protein SUFB HVY54_10995 ENOG4105C3K feS assembly ATPase SufC HVY54_11000 ENOG4105JRK feS assembly protein SufD HVY54_11015 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein HVY54_11020 ENOG4105KMX major outer membrane lipoprotein HVY54_11025 ENOG4105CA9 Pyruvate kinase HVY54_11030 ENOG4105RFR Protein of unknown function (DUF2767) HVY54_11035 ENOG4108PU5 4fe-4S ferredoxin, iron-sulfur binding domain protein HVY54_11040 ENOG4105WE2 aldehyde ferredoxin oxidoreductase HVY54_11045 ENOG4105JVW HVY54_11050 ENOG4108393 oxidoreductase Fe-S subunit HVY54_11055 ENOG4108NWD Cytochrome HVY54_11060 ENOG4108Y7C Conserved Protein HVY54_11065 ENOG4108KTU conserved protein with FAD NAD(P)-binding domain HVY54_11070 ENOG4105N0V mono-oxygenase ydhR HVY54_11090 ENOG4107QI1 Mate efflux family protein HVY54_11095 ENOG4108R6K riboflavin synthase, subunit alpha HVY54_11100 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase HVY54_11105 ENOG4105CZQ inner membrane transport protein YdhC HVY54_11110 ENOG4105F52 Transcriptional regulator HVY54_11125 ENOG4105F27 Major Facilitator HVY54_11130 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) HVY54_11135 ENOG4105K4H Nlp p60 protein HVY54_11140 ENOG4105M2J Glutaredoxin HVY54_11145 ENOG4107QRT dEAD DEAH box helicase HVY54_11155 ENOG4108UYE Lactoylglutathione lyase HVY54_11160 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HVY54_11165 ENOG4108WUH Transcriptional regulator, TetR family HVY54_11170 ENOG4105XZD Fe-S protein HVY54_11175 ENOG4107RGM aldo keto reductase HVY54_11180 ENOG4108Z7T Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) HVY54_11185 ENOG4105DSW Fusaric acid resistance protein HVY54_11190 ENOG4105Y49 secretion protein, HlyD family HVY54_11205 ENOG4108XTF Outer Membrane Lipoprotein HVY54_11215 ENOG410642K Lysozyme inhibitor HVY54_11230 ENOG4107XGF functions in a salvage pathway. Uses pyridoxamine (By similarity) HVY54_11235 ENOG4108K3A Glutathione S-transferase HVY54_11240 ENOG4105DUX Transporter HVY54_11245 ENOG4105CSM endonuclease III HVY54_11255 ENOG4108UQQ Electron transport complex HVY54_11280 ENOG4105M9B inner membrane protein ydgK HVY54_11285 ENOG4105QZ5 OriC-binding nucleoid-associated protein HVY54_11290 ENOG4106C6R beta-lactam resistance protein HVY54_11295 ENOG4105D9R oxidoreductase HVY54_11305 ENOG4105C87 Aminotransferase class I and II HVY54_11310 ENOG4105CI1 PTS System HVY54_11315 ENOG4107P2S Transcriptional regulator HVY54_11320 ENOG4107ZQV short-chain dehydrogenase reductase HVY54_11325 ENOG4105XEA Tetr family transcriptional regulator HVY54_11330 ENOG4105CNT hydrolase family 2 HVY54_11335 ENOG4105CT4 transporter HVY54_11340 ENOG4108QNI outer membrane porin protein HVY54_11345 ENOG4106J39 exported protein HVY54_11350 ENOG4105EIP mannose-6-phosphate isomerase HVY54_11355 ENOG4107GFK fumarate HVY54_11360 ENOG4105C9Q fumarate hydratase class II HVY54_11370 ENOG4105JJR Histidine kinase HVY54_11375 ENOG4108ETY sodium dicarboxylate symporter HVY54_11380 ENOG4107EXC regulatoR HVY54_11385 ENOG4105RA2 Membrane HVY54_11395 ENOG4105D5Q Arginine ornithine antiporter HVY54_11400 ENOG4105C5D exported protein HVY54_11405 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) HVY54_11410 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) HVY54_11415 ENOG4105DSF transport protein HVY54_11430 ENOG4105CVW peptidase s1 and s6 chymotrypsin hap HVY54_11445 ENOG4105D94 Major Facilitator Superfamily HVY54_11450 ENOG4106NZI LysR family Transcriptional regulator HVY54_11455 ENOG4105DAG ROK family HVY54_11460 ENOG4105EWW Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) HVY54_11470 ENOG4108NEM leader-binding protein dmsD HVY54_11475 ENOG4107KGK dmso reductase anchor subunit HVY54_11480 ENOG4105QAX Iron-sulfur HVY54_11485 ENOG4105C3J Cysteine desulfurase HVY54_11490 ENOG4107QY8 reductase HVY54_11495 ENOG4105KBG Protein of unknown function (DUF1161) HVY54_11505 ENOG4108MK9 spermidine N(1)-acetyltransferase HVY54_11520 ENOG4105CXK mandelate racemase muconate lactonizing HVY54_11525 ENOG4105CPQ Dehydrogenase HVY54_11570 ENOG4105K4U addiction module toxin, RelE StbE family HVY54_11590 ENOG4108MXB Protein of unknown function (DUF968) HVY54_11595 ENOG4105HGD Antitermination protein HVY54_11610 ENOG4105VEQ Cold shock protein HVY54_11615 ENOG4105QFS Lysis protein S homolog from lambdoid prophage HVY54_11630 ENOG4108YV9 Protein of unknown function (DUF2514) HVY54_11635 ENOG4105VEQ Cold shock protein HVY54_11650 ENOG4106IAW HVY54_11655 ENOG4106H71 Overexpression increases levels of unsaturated fatty acids and suppresses both the temperature-sensitive fabA6 mutation and cold-sensitive secG null mutation HVY54_11660 ENOG41064WM Uncharacterized protein YcgX HVY54_11665 ENOG4106YSC HVY54_11675 ENOG4105UZW Tail fiber assembly protein HVY54_11680 ENOG4105MN3 Resolvase HVY54_11685 ENOG4105W3V DNA-binding, transcriptional regulator HVY54_11700 ENOG4105DEI Mannitol dehydrogenase HVY54_11705 ENOG41061EV selenium-binding protein YdfZ HVY54_11710 ENOG4107XBN GntR Family Transcriptional Regulator HVY54_11715 ENOG4105EMU Dehydrogenase HVY54_11720 ENOG4105DGW oligopeptidase A HVY54_11725 ENOG4108WTK competence damage-inducible protein HVY54_11730 ENOG4108YDI single-species biofilm formation on inanimate substrate HVY54_11735 ENOG4105FSR swimming returnes to normal when residues 206-207 are both mutated to Ala. Overexpression also leads to a reduction in flagellar abundance and a 20-fold increase in c-di- GMP levels in vivo. Required for aminoglycoside-mediated induction of biofilm formation, it also plays a lesser role in biofilm production in response to other classes of translation inhibitors. The c-di-GMP produced by this enzyme up-regulates poly-GlcNAc production as well as the biofilm synthesis protein PgaD, although c-di-GMP is probably not the main inducing principle. Cyclic-di- GMP is a second messenger which controls cell surface-associated traits in bacteria HVY54_11745 ENOG4105E5W Transporter HVY54_11750 ENOG4108594 Permease of the drug metabolite transporter HVY54_11755 ENOG4106DNR multiple antibiotic resistance protein HVY54_11760 ENOG4108XW0 May be a transcriptional activator of genes involved in the multiple antibiotic resistance (Mar) phenotype. It can also activate genes such as sodA, zwf and micF HVY54_11765 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes HVY54_11785 ENOG4105EGI Transcriptional regulator HVY54_11790 ENOG4105C26 Dehydrogenase HVY54_11795 ENOG4105CSV Glutaminase HVY54_11800 ENOG4105M0C cytoplasmic protein HVY54_11815 ENOG4105FFC UPF0187 protein HVY54_11820 ENOG4107R6G Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate (By similarity) HVY54_11825 ENOG4105K34 Involved in the degradation of phospho-AI-2, thereby terminating induction of the lsr operon and closing the AI-2 signaling cycle. Catalyzes the cleavage of phosphorylated 4,5- dihydroxy-2,3-pentanedione (P-DPD) to 2-phosphoglycolic acid (PG) and another three-carbon compound HVY54_11830 ENOG41061GT Aldolase HVY54_11850 ENOG4105C2J ABC transporter HVY54_11870 ENOG41061P8 Persistence to inhibition of murein or DNA biosynthesis regulatory protein HVY54_11875 ENOG4105CAF HipA N-terminal domain protein HVY54_11930 ENOG4105GVR general secretion pathway protein D HVY54_11930 ENOG4105GVR general secretion pathway protein D HVY54_11985 ENOG4105GVR general secretion pathway protein D HVY54_11985 ENOG4105GVR general secretion pathway protein D HVY54_12005 ENOG4108RQP Major type 1 subunit fimbrin HVY54_12015 ENOG4105CW0 outer membrane usher protein HVY54_12020 ENOG4108WDE Fimbrial protein HVY54_12025 ENOG4106318 fimbrial-like protein YdeR HVY54_12030 ENOG4106PIH fimbrial-like protein ydeQ HVY54_12035 ENOG4107QKC Oxidoreductase alpha (molybdopterin) subunit HVY54_12050 ENOG4105ENH Sulfatase HVY54_12055 ENOG4105C4X radical SAM domain protein HVY54_12065 ENOG4105CQ0 ABC transporter HVY54_12070 ENOG4105PE1 Receptor HVY54_12075 ENOG4107RAN Peptidase, M16 HVY54_12080 ENOG4105CVK Glutamate decarboxylase HVY54_12085 ENOG4105E5D amino acid HVY54_12090 ENOG4105F32 YngK protein HVY54_12100 ENOG4105BZU Histidine kinase HVY54_12105 ENOG4105BZU Histidine kinase HVY54_12110 ENOG4108UQS dipeptidase HVY54_12115 ENOG4105DEF Extracellular solute-binding protein, family 5 HVY54_12125 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HVY54_12130 ENOG4105C3U ABC transporter HVY54_12135 ENOG4107H6U ABC transporter HVY54_12140 ENOG4105DUM transcriptional regulator, lysR family HVY54_12145 ENOG4107QP7 CoA-transferase subunit A HVY54_12150 ENOG4107QNJ CoA-transferase subunit B HVY54_12155 ENOG4105CHU acetyl-coa acetyltransferase HVY54_12160 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase HVY54_12165 ENOG4105CY2 Citrate transporter HVY54_12170 ENOG4105DTD Dehydrogenase HVY54_12175 ENOG4108Z9K Osmotically inducible protein HVY54_12180 ENOG4105TPS biofilm-dependent modulation protein HVY54_12185 ENOG4107AV5 Although this protein associates with the 30S subunit of the ribosome it is not considered to be a bona fide ribosomal protein HVY54_12195 ENOG4105DQ4 alcohol dehydrogenase HVY54_12200 ENOG41084S7 Plasmid maintenance system antidote protein HVY54_12205 ENOG4108MG3 formate dehydrogenase HVY54_12210 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein HVY54_12220 ENOG4105RPH Inner membrane protein YddG HVY54_12230 ENOG4108UI3 Leucine Rich repeat HVY54_12235 ENOG4108UI3 Leucine Rich repeat HVY54_12240 ENOG4107QND Nitrite extrusion protein HVY54_12245 ENOG4105CRU nitrate reductase, alpha subunit HVY54_12250 ENOG4108IUE nitrate reductase beta subunit HVY54_12255 ENOG4108NZN Respiratory nitrate reductase 2 delta chain HVY54_12260 ENOG4105D0D Nitrate reductase 2, gamma subunit HVY54_12265 ENOG4105JAB phenazine biosynthesis protein, phzf family HVY54_12270 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase HVY54_12275 ENOG4108MEJ flavin reductase domain protein HVY54_12285 ENOG410600T transposase HVY54_12320 ENOG4105CS6 Rhs element vgr protein HVY54_12330 ENOG4108N27 Glutathione S-transferase HVY54_12335 ENOG4105C85 amino acid HVY54_12340 ENOG4108NS2 receptor HVY54_12345 ENOG4105CHB tonB-dependent Receptor HVY54_12350 ENOG4108WYP Transcriptional regulator HVY54_12355 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein HVY54_12360 ENOG4108Z7F N-acetyltransferase HVY54_12365 ENOG4108T9Y Inner membrane protein ydcZ HVY54_12370 ENOG4105R71 cytoplasmic protein HVY54_12375 ENOG410654E Membrane HVY54_12395 ENOG4105NRK Binding-protein-dependent transport systems, inner membrane component HVY54_12400 ENOG4105D81 ABC transporter, permease HVY54_12405 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HVY54_12410 ENOG4107TYH extracellular solute-binding protein family 1 HVY54_12415 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HVY54_12420 ENOG4105PF0 Antitoxin component of a toxin-antitoxin (TA) module. Functions as an mRNA interferase antitoxin HVY54_12430 ENOG4105RR0 Protein of unknown function (DUF2554) HVY54_12435 ENOG4105CFP Peptidase U32 HVY54_12440 ENOG4108JCI Transcriptional regulator HVY54_12445 ENOG4105DKK Benzoate HVY54_12450 ENOG4105D7V transposase HVY54_12460 ENOG4108KKZ (LipO)protein HVY54_12465 ENOG41088CC tellurite resistance protein tehB HVY54_12470 ENOG4108NKP c4-dicarboxylate transporter malic acid transport protein HVY54_12475 ENOG4107WE3 acetyltransferase YdcK HVY54_12480 ENOG4108Z9I -acetyltransferase HVY54_12485 ENOG4105Z2P Protein of unknown function (DUF465) HVY54_12495 ENOG4105E32 cytoplasmic protein HVY54_12500 ENOG4105DDW LysR family Transcriptional regulator HVY54_12505 ENOG4105C8Q Methyl-accepting chemotaxis HVY54_12510 ENOG4107NK6 Hok/gef family HVY54_12515 ENOG4105UPP uncharacterized protein ydcA HVY54_12520 ENOG4105CPW cytochrome b561 HVY54_12525 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase HVY54_12530 ENOG4105C26 Dehydrogenase HVY54_12535 ENOG4107DB1 DUF218 domain HVY54_12540 ENOG4105CQ7 ATP-dependent helicase HVY54_12550 ENOG41077RS Phosphatase HVY54_12555 ENOG4105E8V Alpha Beta Hydrolase Fold protein HVY54_12560 ENOG4108HPI phosphatidate Cytidylyltransferase HVY54_12565 ENOG4108UMZ Cdp-alcohol phosphatidyltransferase HVY54_12575 ENOG4107S5I aldo keto reductase HVY54_12580 ENOG4107EF2 surface-exposed virulence protein HVY54_12590 ENOG4105WXT Conserved Protein HVY54_12595 ENOG410689M (LipO)protein HVY54_12600 ENOG4107H52 Dicarboxylate transport HVY54_12605 ENOG4105C5I Dehydrogenase HVY54_12610 ENOG41090X5 Heat shock protein hslJ HVY54_12615 ENOG4105IKK cytoplasmic protein HVY54_12620 ENOG4105D95 Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity) HVY54_12625 ENOG4105FCK Membrane HVY54_12630 ENOG4108RW8 Universal stress protein F HVY54_12640 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) HVY54_12650 ENOG4105KUS lysozyme HVY54_12655 ENOG4105QFS Lysis protein S homolog from lambdoid prophage HVY54_12665 ENOG4108Z82 Cell envelope integrity inner membrane protein TolA HVY54_12675 ENOG4105RWQ Protein of unknown function (DUF1364) HVY54_12725 ENOG4107C82 Rac prophage HVY54_12735 ENOG41076J9 exonuclease VIII HVY54_12740 ENOG4108PNI recT protein HVY54_12745 ENOG4106YAH restriction alleviation and modification enhancement HVY54_12750 ENOG41070YT Rac prophage HVY54_12755 ENOG4107160 Rac prophage HVY54_12760 ENOG4107R08 Integrase HVY54_12770 ENOG4105C1J atp-dependent rna helicase HVY54_12785 ENOG4105BZU Histidine kinase HVY54_12790 ENOG4108DG9 Smr protein MutS2 HVY54_12795 ENOG4106KR7 LysR family Transcriptional regulator HVY54_12800 ENOG4105CH2 amidohydrolase HVY54_12810 ENOG4105CFC Transporter HVY54_12815 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) HVY54_12820 ENOG4105DS0 Transcriptional regulator, Crp Fnr family HVY54_12825 ENOG4105Q9Y Universal stress protein HVY54_12830 ENOG4105S5I Membrane HVY54_12835 ENOG4105D64 Mechanosensitive ion channel HVY54_12840 ENOG4107QSI ABC, transporter HVY54_12845 ENOG4105EQ2 LysR family Transcriptional regulator HVY54_12850 ENOG4105ENX hydrolase HVY54_12855 ENOG4105ENX hydrolase HVY54_12865 ENOG4105KXI murein peptide amidase A HVY54_12870 ENOG4107S8C mandelate racemase muconate lactonizing HVY54_12875 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) HVY54_12880 ENOG4108JU8 Transcriptional regulator HVY54_12890 ENOG4105CM6 amino acid regulated cytosolic protein HVY54_12895 ENOG4105K8Z Phage shock protein HVY54_12900 ENOG4105NNG Peripheral inner membrane phage-shock protein HVY54_12905 ENOG4105FM1 phage shock protein C HVY54_12910 ENOG4105YYT phage shock protein B HVY54_12915 ENOG41087YS Phage shock protein A HVY54_12920 ENOG4105E51 psp operon transcriptional activator HVY54_12925 ENOG4108JPW Aminotransferase HVY54_12930 ENOG4105CJP fad dependent oxidoreductase HVY54_12935 ENOG4105C26 Dehydrogenase HVY54_12940 ENOG4107VRI Transcriptional regulator HVY54_12945 ENOG4108Z86 Glutamine amidotransferase HVY54_12950 ENOG4105CFQ glutamine synthetase HVY54_12960 ENOG4105CUB amino acid HVY54_12965 ENOG4105N0E Protein of unknown function (DUF2543) HVY54_12970 ENOG4108HIY periplasmic HVY54_12975 ENOG4108I5W peptide transport system, permease protein HVY54_12980 ENOG4108EU3 peptide transport system, permease HVY54_12985 ENOG4108JQ3 Peptide ABC transporter ATP-binding protein HVY54_12990 ENOG4108JQ2 peptide transport system atp-binding protein HVY54_12995 ENOG4105C2C drug resistance transporter, Bcr CflA HVY54_13000 ENOG4105ENJ RND efflux system, outer membrane lipoprotein HVY54_13010 ENOG4105C1P efflux transporter, rnd family, mfp subunit HVY54_13015 ENOG41067SE Tetr family transcriptional regulator HVY54_13020 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH HVY54_13025 ENOG4105Q4T oxidoreductase HVY54_13040 ENOG4105BZU Histidine kinase HVY54_13045 ENOG410643D UPF0509 protein HVY54_13050 ENOG4105N2W Transcriptional regulator HVY54_13060 ENOG4108ZJT translation initiation factor, Sui1 HVY54_13070 ENOG4105CFV Tetratricopeptide repeat protein HVY54_13075 ENOG4105Q4A inner membrane protein yciS HVY54_13080 ENOG4105EYK Phosphatidylglycerophosphatase B HVY54_13090 ENOG4107QM5 aconitate hydratase HVY54_13110 ENOG4107R11 Transcriptional regulator HVY54_13115 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) HVY54_13120 ENOG4105RKX Protein of unknown function (DUF2498) HVY54_13125 ENOG4105ERU peptidase HVY54_13130 ENOG4105UBK short-chain dehydrogenase reductase HVY54_13135 ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase HVY54_13140 ENOG4105FE9 pseudouridine synthase HVY54_13145 ENOG4105EG3 transmembrane signal peptide protein HVY54_13150 ENOG4107RTD sua5 ycio yrdc ywlc family protein HVY54_13155 ENOG4105DB7 PHP domain protein HVY54_13165 ENOG4105CRQ synthase (Component I) HVY54_13170 ENOG4108EFP Anthranilate synthase component II HVY54_13175 ENOG4105DK0 Indole-3-glycerol phosphate synthase HVY54_13195 ENOG4108Z9Z response to DNA damage stimulus HVY54_13200 ENOG4108N8X transition metal ion binding HVY54_13205 ENOG4105EIF outer membrane protein W HVY54_13225 ENOG4105NAU thioesterase Superfamily protein HVY54_13230 ENOG410822N TonB family HVY54_13235 ENOG4105K9H YciI-like protein HVY54_13240 ENOG4107SVH Potassium channel protein HVY54_13260 ENOG4108JQ7 (ABC) transporter HVY54_13265 ENOG4105C3U ABC transporter HVY54_13270 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HVY54_13275 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HVY54_13280 ENOG4108J59 Extracellular solute-binding protein, family 5 HVY54_13285 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein HVY54_13290 ENOG4105C0A alcohol dehydrogenase HVY54_13295 ENOG4105VNT transposase (IS4 family) protein HVY54_13300 ENOG4107104 thymidine kinase HVY54_13305 ENOG4108SAU DNA-binding protein H-ns HVY54_13310 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase HVY54_13315 ENOG4105I93 response regulator HVY54_13320 ENOG4105D78 K07001 NTE family protein HVY54_13330 ENOG4105CIY formyltetrahydrofolate deformylase HVY54_13350 ENOG41076YT nitrate reductase, gamma subunit HVY54_13355 ENOG4105R3A Nitrate reductase HVY54_13360 ENOG4108IUE nitrate reductase beta subunit HVY54_13365 ENOG4105CRU nitrate reductase, alpha subunit HVY54_13370 ENOG4105DQQ Major facilitator superfamily MFS_1 HVY54_13375 ENOG4105BZU Histidine kinase HVY54_13380 ENOG4105WH1 Two component transcriptional regulator luxr family HVY54_13385 ENOG4105ID0 Putative invasin HVY54_13390 ENOG41090EX DsrE family HVY54_13395 ENOG4108NH8 Cation transport protein HVY54_13400 ENOG4105WS7 Cation transport regulator HVY54_13405 ENOG4105EWV Sodium calcium exchanger membrane region HVY54_13425 ENOG41063JG Transcriptional regulator HVY54_13430 ENOG4108YY7 Invasion gene expression up-regulator SirB HVY54_13435 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) HVY54_13445 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) HVY54_13455 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) HVY54_13460 ENOG4105C5T Phosphoribosyl pyrophosphate synthase HVY54_13465 ENOG4105CHH sulfate transporter HVY54_13470 ENOG4105MGX transcription activated by CRP (cyclic AMP receptor protein), a global transcription factor involved in regulation of metabolism in enteric bacteria HVY54_13480 ENOG4105C3G gtp-binding protein HVY54_13490 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family HVY54_13495 ENOG4105CMT Dihydroxyacetone kinase HVY54_13500 ENOG4108UTZ Dihydroxyacetone kinase HVY54_13505 ENOG4105VDH Dihydroxyacetone kinase HVY54_13520 ENOG4105EHG Permease protein HVY54_13525 ENOG4105E0A ABC, transporter HVY54_13530 ENOG4108BSC Methyltransferase HVY54_13535 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase HVY54_13550 ENOG4108T7K Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Increasing levels of c-di-GMP lead to decreased motility (By similarity) HVY54_13560 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A HVY54_13580 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) HVY54_13590 ENOG4105ED1 spovr family HVY54_13605 ENOG410635M Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein (By similarity) HVY54_13610 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) HVY54_13615 ENOG4105KT5 UmuD protein HVY54_13620 ENOG4106PXS Toxin, which has some hemolytic activity towards mammalian cells. Acts by forming a pore-like structure upon contact with mammalian cells HVY54_13630 ENOG4105FBJ fumarylacetoacetate (faa) hydrolase HVY54_13640 ENOG41066UD Inhibits activity of g-type lysozyme, which confers increased lysozyme tolerance to the bacterium HVY54_13645 ENOG4105S66 prophage protein HVY54_13655 ENOG4107QMS site-determining protein HVY54_13690 ENOG410658X HVY54_13710 ENOG4105BZU Histidine kinase HVY54_13715 ENOG410738I uncharacterized protein ymgC HVY54_13725 ENOG41077SS Probably a connector protein for RcsB C regulation of biofilm formation, providing additional signal input into the two- component signaling pathway. May serve to stimulate biofilm maturation, probably via the Rcs phosphorelay. Mild overexpression at 16 degrees Celsius increases the production of colanic acid, an exopolysaccharide and matrix component, and reduces adhesive curli fimbriae expression. Both of these effects require RcsB HVY54_13730 ENOG4105WKE Probably a connector protein for RcsB C regulation of biofilm formation, providing additional signal input into the two- component signaling pathway. Partially antagonizes the activities of YmgA and AriR, proteins that, via the Rcs phosphorelay, promote the synthesis of colanic acid, an exopolysaccharide and matrix component HVY54_13735 ENOG4105BZU Histidine kinase HVY54_13740 ENOG4108XDN Transcriptional regulator HVY54_13745 ENOG41064WM Uncharacterized protein YcgX HVY54_13765 ENOG4108HMX isocitrate dehydrogenase (NADP) HVY54_13770 ENOG4108R99 pseudouridine synthase HVY54_13790 ENOG4107QTF adenylosuccinate lyase HVY54_13795 ENOG4105XJC Two component transcriptional regulator (Winged helix family HVY54_13800 ENOG4105IFJ Histidine kinase HVY54_13805 ENOG4105EZE Cupin 4 family protein HVY54_13815 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HVY54_13825 ENOG4105D38 putrescine abc transporter HVY54_13830 ENOG4107RUE extracellular solute-binding protein family 1 HVY54_13835 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) HVY54_13845 ENOG4105D60 lipoprotein releasing system transmembrane protein HVY54_13850 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) HVY54_13855 ENOG4105D60 lipoprotein releasing system transmembrane protein HVY54_13860 ENOG4105IQC Inner membrane protein YcfT HVY54_13865 ENOG4108JA2 transcriptioN-repair coupling factor HVY54_13870 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein HVY54_13875 ENOG4105RC8 Reduces the permeability of the outer membrane to copper. Seems to be involved in the regulation of biofilm formation. May decrease biofilm formation by repressing cell-cell interaction and cell surface interaction HVY54_13880 ENOG4108IND Tetr family transcriptional regulator HVY54_13885 ENOG4107MBR 17 kDa surface antigen HVY54_13890 ENOG4105CEP NADH dehydrogenase HVY54_13905 ENOG4108RUM thiamine kinase HVY54_13910 ENOG4108WEF Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b) (By similarity) HVY54_13915 ENOG41090DQ Lipoprotein HVY54_13920 ENOG4105K59 histidine triad (HIT) protein HVY54_13925 ENOG4105CNM Receptor HVY54_13930 ENOG4105CI1 PTS System HVY54_13935 ENOG4105F8V Hydrolase, tatD family HVY54_13940 ENOG4107QRG dna polymerase iii HVY54_13950 ENOG4105HHA aminodeoxychorismate lyase HVY54_13955 ENOG4105YAZ 4-amino-4-deoxychorismate lyase HVY54_13960 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) HVY54_13965 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) HVY54_13970 ENOG4105CHR reductase HVY54_13975 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase HVY54_13995 ENOG4105FCQ metal-binding, possibly nucleic acid-binding protein HVY54_14000 ENOG4108UHJ MAF-like protein HVY54_14005 ENOG4105EI2 Pseudouridine synthase HVY54_14010 ENOG4107QQB Ribonuclease E HVY54_14015 ENOG4105DTJ flagellar hook-associated protein HVY54_14020 ENOG4105E1Q flagellar hook-associated protein HVY54_14025 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj HVY54_14040 ENOG4105CGA flagellar basal-body rod protein FlgG HVY54_14045 ENOG4108KPB Flagellar basal-body rod protein FlgF HVY54_14050 ENOG4105BZE flagellar hook protein, FlgE HVY54_14055 ENOG4105W00 Flagellar hook capping protein HVY54_14060 ENOG4108ZC9 flagellar basal-body rod protein flgc HVY54_14065 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) HVY54_14070 ENOG4105CKS Flagella basal body P-ring formation protein flgA HVY54_14075 ENOG4105M9M anti-sigma28 factor FlgM HVY54_14080 ENOG4105QVD Flagella synthesis protein FlgN HVY54_14085 ENOG4105CJR Integral membrane protein (MviN HVY54_14090 ENOG4105EP9 oxidoreductase HVY54_14100 ENOG4105D9U N-acetyltransferase HVY54_14110 ENOG4105E9S glutaredoxin 2 HVY54_14115 ENOG4105F3T (LipO)protein HVY54_14120 ENOG4105EKE dihydroorotase HVY54_14135 ENOG4105PVA Biofilm formation regulatory protein BssS HVY54_14145 ENOG4106974 biofilm formation HVY54_14150 ENOG4105DS1 cytochrome b561 HVY54_14155 ENOG4108YYC ycei family HVY54_14165 ENOG4105D1S lipid A biosynthesis HVY54_14175 ENOG4108W47 Acidic protein msyB HVY54_14180 ENOG4105NAC (LipO)protein HVY54_14185 ENOG4105VNT transposase (IS4 family) protein HVY54_14190 ENOG4105C3A Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs) (By similarity) HVY54_14205 ENOG4107RZC phospholipase d HVY54_14210 ENOG4108UVJ appr-1-p processing domain protein HVY54_14225 ENOG41090QH cryptic curlin major subunit HVY54_14230 ENOG4108U0V Curli are coiled surface structures that assemble preferentially at growth temperatures below 37 degrees Celsius. Curli can bind to fibronectin. The minor subunit is the nucleation component of curlin monomers HVY54_14235 ENOG41086KC Transcriptional regulator HVY54_14240 ENOG4108XDW curli assembly protein CsgE HVY54_14245 ENOG4108WYR Curli production assembly transport component, CsgF HVY54_14250 ENOG4105P8Q Curli production assembly transport component CsgG HVY54_14255 ENOG4108UQ5 membrane protein YcdZ HVY54_14260 ENOG4107XHZ cytoplasmic chaperone TorD family protein HVY54_14270 ENOG4105JPG D-isomer specific 2-hydroxyacid dehydrogenase HVY54_14280 ENOG4108T85 Membrane HVY54_14325 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) HVY54_14330 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) HVY54_14340 ENOG4108YXN Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity) HVY54_14350 ENOG41081XD Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity) HVY54_14355 ENOG4105D5K Hemolysin activator protein HVY54_14360 ENOG4105CKT filamentous hemagglutinin HVY54_14370 ENOG4105X0I Fimbrial HVY54_14375 ENOG4108AF8 Chaperone HVY54_14380 ENOG4105CW0 outer membrane usher protein HVY54_14390 ENOG4108MQF Chaperone HVY54_14395 ENOG4105CHR reductase HVY54_14410 ENOG4105CXC rtn protein HVY54_14415 ENOG4105BZU Histidine kinase HVY54_14420 ENOG4108TUY outer membrane protein PgaA HVY54_14425 ENOG4107BJW polysaccharide deacetylase HVY54_14430 ENOG4105CND Glycosyl transferase, family 2 HVY54_14440 ENOG4105D5M phosphate starvation-inducible protein HVY54_14450 ENOG410650H (LipO)protein HVY54_14465 ENOG4105CK7 Sodium proline symporter HVY54_14475 ENOG4105C26 Dehydrogenase HVY54_14480 ENOG4108R86 Transcriptional regulator HVY54_14515 ENOG4105C2W permease HVY54_14520 ENOG4105XF5 Escherichia coli IMT2125 genomic chromosome, IMT2125 HVY54_14530 ENOG4105XH3 HVY54_14535 ENOG4105D6F Phosphatase HVY54_14560 ENOG4108J2R molybdopterin oxidoreductase HVY54_14565 ENOG4105CUW cytochrome C-TYPE protein HVY54_14570 ENOG4106WF9 DNA-binding transcriptional regulator TorR HVY54_14575 ENOG4108SV3 Tmao reductase system periplasmic protein tort HVY54_14580 ENOG4105BZU Histidine kinase HVY54_14585 ENOG4105HEE Binding Domain protein HVY54_14590 ENOG4106H71 Overexpression increases levels of unsaturated fatty acids and suppresses both the temperature-sensitive fabA6 mutation and cold-sensitive secG null mutation HVY54_14605 ENOG4105VEQ Cold shock protein HVY54_14610 ENOG41060EU Cold shock-like protein HVY54_14620 ENOG4108Y9B (LipO)protein HVY54_14625 ENOG4108W78 Pfam:DUF1017 HVY54_14630 ENOG4105E3R (LipO)protein HVY54_14635 ENOG4105DAY polysaccharide export protein HVY54_14640 ENOG4107ZF2 Phosphatase HVY54_14645 ENOG4108F2G Chain length determinant protein HVY54_14650 ENOG4105D6F Phosphatase HVY54_14660 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii HVY54_14665 ENOG4105C4M (Ubiquinol oxidase) subunit I HVY54_14670 ENOG4105MVP hydrogenase-1 operon protein HyaF HVY54_14675 ENOG4108VXY Hydrogenase-1 operon protein HyaE HVY54_14680 ENOG4108USZ hydrogenase HVY54_14685 ENOG4105X7T Ni Fe-hydrogenase, b-type cytochrome subunit HVY54_14690 ENOG4105DPX Hydrogenase, large subunit HVY54_14695 ENOG4105E3S small subunit HVY54_14705 ENOG4108MN8 Membrane HVY54_14710 ENOG4108Z0T Part of a sulfur-relay system (By similarity) HVY54_14715 ENOG4105VSY K01512 acylphosphatase EC 3.6.1.7 HVY54_14730 ENOG4105K4P CoA-binding domain protein HVY54_14745 ENOG41088T4 Helicase IV HVY54_14750 ENOG410901E Membrane HVY54_14755 ENOG4105EM2 membrane HVY54_14760 ENOG4108RZ1 DNA transformation protein HVY54_14770 ENOG4105UYK outer membrane protein a HVY54_14780 ENOG4105DAN ATP-dependent protease HVY54_14790 ENOG4105WFT During stationary phase, converts 70S ribosomes to an inactive dimeric form (100S ribosomes) (By similarity) HVY54_14795 ENOG4108Q2G (LipO)protein HVY54_14800 ENOG4105DY2 Paraquat-inducible protein b HVY54_14805 ENOG4105F1S paraquat-inducible protein a HVY54_14810 ENOG4105C5H ABC transporter HVY54_14820 ENOG4105QVC MOSC domain-containing protein HVY54_14825 ENOG4108T7E Contributes to the efficiency of the cell division process by stabilizing the polymeric form of the cell division protein FtsZ. Acts by promoting interactions between FtsZ protofilaments and suppressing the GTPase activity of FtsZ (By similarity) HVY54_14835 ENOG4106PH7 chaperone HVY54_14840 ENOG4105MX3 Fimbrial HVY54_14845 ENOG4105Q7J Fimbrial HVY54_14850 ENOG4108MDY Fimbrial HVY54_14855 ENOG4105CW0 outer membrane usher protein HVY54_14860 ENOG4106JJN Part of the elfADCG-ycbUVF fimbrial operon, which promotes adhesion of bacteria to different abiotic surfaces. Could be required for the biogenesis of the ElfA fimbriae HVY54_14865 ENOG41071VI Part of the elfADCG-ycbUVF fimbrial operon, which promotes adhesion of bacteria to different abiotic surfaces. ElfA is the major fimbrial subunit produced by this operon HVY54_14870 ENOG4108UZX fmn reductase HVY54_14875 ENOG4105GVF (ABC) transporter HVY54_14885 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component HVY54_14890 ENOG4105E2Y ABC, transporter HVY54_14895 ENOG4105CD8 aminopeptidase N HVY54_14900 ENOG4107RH7 Nicotinate phosphoribosyltransferase HVY54_14910 ENOG4105FCK Membrane HVY54_14915 ENOG4105CGF Aromatic amino acid aminotransferase HVY54_14920 ENOG4105C5X domain protein HVY54_14925 ENOG4105EAQ (twin-arginine translocation) pathway signal HVY54_14930 ENOG4105DIT ErfK YbiS YcfS YnhG family protein HVY54_14940 ENOG4105DAH Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF (By similarity) HVY54_14950 ENOG4106371 Methyltransferase HVY54_14955 ENOG4107S90 membrAne HVY54_14960 ENOG4107VR7 transferase activity, transferring phosphorus-containing groups HVY54_14975 ENOG4105T0Z Conserved Protein HVY54_14985 ENOG4105BZ1 (ABC) transporter HVY54_15000 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) HVY54_15010 ENOG4108K0D peptidase, M48 HVY54_15025 ENOG4107VMU Membrane HVY54_15030 ENOG4105DDY UPF0142 protein ycaO HVY54_15035 ENOG4105TMB Formate nitrite transporter HVY54_15040 ENOG4105C6N Formate acetyltransferase HVY54_15045 ENOG4105ZTC transcriptional activator, Ogr delta HVY54_15180 ENOG4105ED4 portal protein HVY54_15205 ENOG4105VZ1 Replication Protein HVY54_15245 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HVY54_15250 ENOG4105F1A Pyruvate formate-lyase HVY54_15260 ENOG4105E5D amino acid HVY54_15270 ENOG4105CHJ isochorismatase hydrolase HVY54_15275 ENOG4107KGK dmso reductase anchor subunit HVY54_15280 ENOG4105QAX Iron-sulfur HVY54_15285 ENOG4107QY8 reductase HVY54_15295 ENOG4105D1H recombination factor protein RarA HVY54_15305 ENOG4105CNU cell division protein FtsK HVY54_15315 ENOG4105C3M thioredoxin reductase HVY54_15320 ENOG4108JJ9 ABC, transporter HVY54_15325 ENOG4108JJ8 (ABC) transporter HVY54_15335 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) HVY54_15345 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit HVY54_15355 ENOG4105VEQ Cold shock protein HVY54_15360 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) HVY54_15365 ENOG4105DJY efflux transporter, rnd family, mfp subunit HVY54_15370 ENOG4108MJ5 VirK protein HVY54_15375 ENOG4105CPB ATP-dependent endonuclease of the OLD family HVY54_15380 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) HVY54_15385 ENOG4105DWU Membrane HVY54_15395 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) HVY54_15400 ENOG4105C7K acetolactate synthase HVY54_15405 ENOG4105C5W Aldolase HVY54_15410 ENOG4105CGD Nad-dependent epimerase dehydratase HVY54_15415 ENOG4107VBM 3-beta hydroxysteroid dehydrogenase isomerase HVY54_15420 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase HVY54_15435 ENOG41064MM (LipO)protein HVY54_15440 ENOG4105E5Z arginine transporter ATP-binding subunit HVY54_15445 ENOG4106PMH Extracellular solute-binding protein family 3 HVY54_15450 ENOG4105GBT ABC transporter HVY54_15455 ENOG4105DMR ABC, transporter HVY54_15460 ENOG4106TNF Periplasmic binding protein HVY54_15485 ENOG4105RBQ inner membrane protein ybjO HVY54_15490 ENOG4105D38 putrescine abc transporter HVY54_15495 ENOG4105F38 ABC transporter, permease HVY54_15500 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HVY54_15505 ENOG4107RUE extracellular solute-binding protein family 1 HVY54_15510 ENOG4108RMJ sensory transduction regulator HVY54_15520 ENOG4108DBC nitroreductase HVY54_15525 ENOG4105X20 member of the soxRS regulon which mediates in part the increased levels of superoxide in response to oxidative stress HVY54_15530 ENOG41090BQ Glutaredoxin HVY54_15535 ENOG4105GWF inner membrane protein YbjM HVY54_15545 ENOG4108RFG Tetr family transcriptional regulator HVY54_15550 ENOG4106UW1 Major Facilitator superfamily HVY54_15555 ENOG4108HCJ Hydrolase HVY54_15565 ENOG4107QF7 multi-drug HVY54_15570 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase HVY54_15575 ENOG4107FB0 transcriptional regulator DeoR family HVY54_15580 ENOG4105DZ1 carboxypeptidase HVY54_15585 ENOG4108TGY Glutathione S-transferase HVY54_15590 ENOG4105D8V Glucose sorbosone dehydrogenase HVY54_15595 ENOG4105UFT Represses biofilm formation in M9C glu and LB glu media but not in M9C and LB media. Seems to act as a global regulator of several genes involved in catabolite repression and stress response and regulation of the uptake and export of signaling pathways. Could be involved the regulation of indole as well as uptake and export of AI-2 through a cAMP-dependent pathway HVY54_15615 ENOG41064RH membrane protein YliF HVY54_15620 ENOG4105BZU Histidine kinase HVY54_15625 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HVY54_15635 ENOG4105DEF Extracellular solute-binding protein, family 5 HVY54_15645 ENOG4105D44 asparaginase HVY54_15650 ENOG4105CVM Molybdenum cofactor synthesis domain protein HVY54_15655 ENOG4105D06 uba thif-type nad fad binding protein HVY54_15660 ENOG4107T9Z Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) HVY54_15665 ENOG4105F1A Pyruvate formate-lyase HVY54_15675 ENOG4108HCJ Hydrolase HVY54_15680 ENOG41072TH Protein of unknown function (DUF1479) HVY54_15685 ENOG4105C5H ABC transporter HVY54_15690 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein HVY54_15695 ENOG4105F4P )-transporter HVY54_15700 ENOG4105KST dependent repressor HVY54_15710 ENOG4108I6E Sulfatase HVY54_15715 ENOG4108T1M outer membrane protein x HVY54_15725 ENOG4107AQZ Membrane HVY54_15735 ENOG4107R0W ABC transporter HVY54_15740 ENOG4105E5Q amino acid AbC transporter HVY54_15745 ENOG4105CDA abc transporter atp-binding protein HVY54_15750 ENOG4105D8X mechanosensitive ion channel HVY54_15760 ENOG4105ZY9 UPF0379 protein ybiM HVY54_15765 ENOG4108ESX Receptor HVY54_15775 ENOG4105KSC Transcriptional regulator, TraR DksA family HVY54_15780 ENOG4105VR4 UPF0379 protein ybiJ HVY54_15785 ENOG4105DG4 malate L-lactate dehydrogenase HVY54_15790 ENOG4108MTB glycosyl transferase family HVY54_15795 ENOG4105DVT helicase HVY54_15805 ENOG4105C1J atp-dependent rna helicase HVY54_15810 ENOG4107MVR Transcriptional regulator HVY54_15820 ENOG4105CJ1 ABC, transporter HVY54_15825 ENOG4107QWP ABC-2 type transporter HVY54_15830 ENOG4107QWP ABC-2 type transporter HVY54_15835 ENOG4105I9U inner membrane protein ybhQ HVY54_15840 ENOG4105X23 Endonuclease Exonuclease phosphatase HVY54_15845 ENOG4105DZQ phospholipase D Transphosphatidylase HVY54_15850 ENOG4107UXM Membrane HVY54_15855 ENOG410733J conserved inner membrane protein HVY54_15860 ENOG4105HFZ Membrane HVY54_15865 ENOG4108ZAF Molybdopterin HVY54_15870 ENOG4105M00 molybdopterin converting factor, subunit 1 HVY54_15880 ENOG4108RIR Molybdenum cofactor biosynthesis protein HVY54_15890 ENOG4105CHW UPF0052 protein HVY54_15900 ENOG4105E78 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) HVY54_15905 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) HVY54_15920 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) HVY54_15925 ENOG4108V1U phospholipid-binding protein HVY54_15930 ENOG4106KTS Inner membrane protein yeaI HVY54_15935 ENOG4105UZW Tail fiber assembly protein HVY54_15940 ENOG410685N tail fiber protein HVY54_16015 ENOG4105IM0 capsid protein HVY54_16025 ENOG4105F7J membrane-bound serine protease HVY54_16040 ENOG4105FKG DNA packaging protein HVY54_16055 ENOG4105IM0 capsid protein HVY54_16125 ENOG4107DE1 head-to-tail joining protein HVY54_16130 ENOG4105UZW Tail fiber assembly protein HVY54_16135 ENOG4105FKG DNA packaging protein HVY54_16140 ENOG4106YSC HVY54_16145 ENOG41064WM Uncharacterized protein YcgX HVY54_16150 ENOG4106050 phage regulatory protein, rha family HVY54_16160 ENOG4105SZK Rz endopeptidase from lambdoid prophage DLP12 HVY54_16165 ENOG4105KUS lysozyme HVY54_16170 ENOG4105QFS Lysis protein S homolog from lambdoid prophage HVY54_16180 ENOG4105HRS Antitermination protein HVY54_16215 ENOG4105NY2 NinB protein HVY54_16325 ENOG4108I1J Integrase HVY54_16330 ENOG4105NBR Pectinesterase HVY54_16335 ENOG4107QM5 aconitate hydratase HVY54_16340 ENOG4107QPK )-transporter HVY54_16345 ENOG4105C7F AcnD-accessory protein PrpF HVY54_16350 ENOG4105F04 LysR family Transcriptional regulator HVY54_16360 ENOG4108K4B hydrolase HVY54_16370 ENOG4105E0C molybdate abc transporter HVY54_16375 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein HVY54_16385 ENOG4105F4R Transcriptional regulator mode HVY54_16390 ENOG4105DKW ABC transporter HVY54_16395 ENOG4105CMR udp-glucose 4-epimerase HVY54_16400 ENOG4105F0Z galactose-1-phosphate uridylyltransferase HVY54_16410 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) HVY54_16420 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) HVY54_16425 ENOG4105JND homeobox protein HVY54_16430 ENOG4105PGM cation diffusion facilitator family transporter HVY54_16435 ENOG4106Z1T Nicotinamide Mononucleotide Transporter HVY54_16440 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) HVY54_16485 ENOG4105UFD tol-pal system protein YbgF HVY54_16490 ENOG4105KCK Peptidoglycan-associated lipoprotein HVY54_16500 ENOG4108Z82 Cell envelope integrity inner membrane protein TolA HVY54_16510 ENOG4105E02 MotA TolQ exbB proton channel HVY54_16515 ENOG4107YD3 Thioesterase HVY54_16520 ENOG4105KJB cyd operon protein YbgE HVY54_16530 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii HVY54_16535 ENOG4105C4M (Ubiquinol oxidase) subunit I HVY54_16550 ENOG4107WFU Glutamate mutase subunit sigma HVY54_16560 ENOG4105DJI Methylaspartate mutase, E subunit HVY54_16585 ENOG4107GFK fumarate HVY54_16590 ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase HVY54_16595 ENOG4105ETT transcriptional Regulator, LysR family HVY54_16600 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha HVY54_16610 ENOG4105C7S Dehydrogenase HVY54_16615 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 HVY54_16620 ENOG4105E33 succinate dehydrogenase HVY54_16625 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) HVY54_16630 ENOG4105N1I succinate dehydrogenase, hydrophobic membrane anchor protein HVY54_16635 ENOG4108UTY succinate dehydrogenase, cytochrome b556 subunit HVY54_16645 ENOG4105BZN citrate synthase HVY54_16650 ENOG4106UBK fimbrial-like adhesin protein HVY54_16655 ENOG4106PG1 outer membrane usher protein HVY54_16660 ENOG4108TTM chaperone HVY54_16665 ENOG4108MY7 Fimbrial HVY54_16670 ENOG4108KK1 membrane protein AbrB duplication HVY54_16685 ENOG4107R7A Allophanate hydrolase subunit 2 HVY54_16690 ENOG4105P4J Allophanate hydrolase, subunit 1 HVY54_16695 ENOG4107QNR UPF0135 protein HVY54_16700 ENOG4105DUX Transporter HVY54_16705 ENOG4105CVP deoxyribo-dipyrimidine photolyase HVY54_16710 ENOG4107SEY Conserved Protein HVY54_16715 ENOG4105XIQ Protein of unknown function (DUF2517) HVY54_16735 ENOG4108R80 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity) HVY54_16740 ENOG4105C08 Histidine kinase HVY54_16745 ENOG4105EEX Two component transcriptional regulator (Winged helix family HVY54_16755 ENOG4105CXN decarboxylase HVY54_16760 ENOG4105D5Q Arginine ornithine antiporter HVY54_16765 ENOG4107QIX Phosphoglucomutase (EC 5.4.2.2 HVY54_16770 ENOG4107CDU Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated (By similarity) HVY54_16775 ENOG4105EV9 Alpha Beta Hydrolase HVY54_16780 ENOG4105NNH LexA regulated protein HVY54_16785 ENOG4105MHQ Low-potential electron donor to a number of redox enzymes (By similarity) HVY54_16795 ENOG41090R7 Ferric uptake HVY54_16800 ENOG4105GX6 (LipO)protein HVY54_16815 ENOG4105CI1 PTS System HVY54_16825 ENOG4105CE4 GlcNAc 6-P deacetylase HVY54_16830 ENOG4105E2R ROK family HVY54_16835 ENOG4105D4U had-superfamily hydrolase, subfamily iia HVY54_16840 ENOG4105CAQ asparagine synthetase HVY54_16880 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family HVY54_16890 ENOG4105C9A Phoh family HVY54_16900 ENOG4108JU5 Magnesium and cobalt efflux protein HVY54_16905 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) HVY54_16910 ENOG4107RP9 extracellular solute-binding protein, family 3 HVY54_16915 ENOG4105EAD ABC transporter HVY54_16920 ENOG4105DRP amino acid AbC transporter HVY54_16925 ENOG4105CDA abc transporter atp-binding protein HVY54_16935 ENOG4105F7F Chaperone HVY54_16945 ENOG41069CF Protein of unknown function (DUF1266) HVY54_16950 ENOG4107JFD Sel1 repeat HVY54_16955 ENOG4105QFC Hsc56 co-chaperone of HscC HVY54_16960 ENOG41069CF Protein of unknown function (DUF1266) HVY54_16965 ENOG4105EUU Sel1 domain protein repeat-containing protein HVY54_16970 ENOG4107PAI alpha helical protein HVY54_16985 ENOG4105DJF DNA polymerase III, delta' subunit HVY54_16995 ENOG4108TGR phosphatase HVY54_17000 ENOG4105KEM Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) HVY54_17010 ENOG4105CJN penicillin-binding protein HVY54_17015 ENOG4105CNI cell division protein FtsW HVY54_17020 ENOG4105K6T rare lipoprotein A HVY54_17025 ENOG4105DZ1 carboxypeptidase HVY54_17040 ENOG41064T2 transcriptional regulator, lysR family HVY54_17050 ENOG410607N Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatE shares overlapping functions with TatA (By similarity) HVY54_17070 ENOG41079UR PagP is required both for biosynthesis of hepta-acylated lipid A species containing palmitate and for resistance to cationic antimicrobial peptides (CAMPs). It catalyzes the transfer of a palmitate chain (16 0) from the sn-1 position of a glycerophospholipid to the free hydroxyl group of the (R)-3- hydroxymyristate chain at position 2 of lipid A (endotoxin) (By similarity) HVY54_17075 ENOG4105CEE C4-dicarboxylate transporter HVY54_17080 ENOG4106YYS transcriptional regulatory protein HVY54_17085 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism HVY54_17090 ENOG4105DUA (citrate (pro-3S)-lyase ligase HVY54_17100 ENOG4105CI0 Citrate lyase HVY54_17105 ENOG4105CHY citrate lyase, alpha HVY54_17120 ENOG4107QPK )-transporter HVY54_17125 ENOG4105KTS ribonuclease HVY54_17130 ENOG4105NXH GreA GreB family elongation factor HVY54_17135 ENOG4105E2A Dehydrogenase HVY54_17140 ENOG4108U51 Universal stress protein HVY54_17145 ENOG4108JU3 Alkyl hydroperoxide reductase HVY54_17150 ENOG4105D3R alkyl hydroperoxide reductase HVY54_17155 ENOG4108KHN disulfide isomerase, thiol-disulfide oxidase HVY54_17160 ENOG4105DQS Transcriptional regulator HVY54_17165 ENOG4105BZV Phosphoadenosine phosphosulfate reductase HVY54_17170 ENOG4105GTN ParB Domain Protein Nuclease HVY54_17175 ENOG4105CHM Aminotransferase HVY54_17180 ENOG4107SCQ Iron-containing alcohol dehydrogenase HVY54_17185 ENOG4105VCD cytoplasmic protein HVY54_17190 ENOG4105D22 carbon starvation protein HVY54_17195 ENOG4108TZA Required for optimal enterobactin synthesis. Acts as a proofreading enzyme that prevents EntB misacylation by hydrolyzing the thioester bound existing between EntB and wrongly charged molecules (By similarity) HVY54_17200 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase HVY54_17205 ENOG4105WQI isochorismatase HVY54_17210 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase HVY54_17215 ENOG4105E4F Isochorismate synthase HVY54_17220 ENOG4105PEC Iron-enterobactin transporter periplasmic binding protein HVY54_17230 ENOG4105DQ5 transport system permease protein HVY54_17235 ENOG4105TVJ transport system, permease HVY54_17240 ENOG4105E0A ABC, transporter HVY54_17245 ENOG4108QY5 Ferric enterobactin transport protein HVY54_17250 ENOG4105C0W non-ribosomal peptide synthetase HVY54_17255 ENOG41085A6 mbth domain-containing protein HVY54_17260 ENOG4105E93 esterase HVY54_17265 ENOG4107RNH Outer membrane receptor FepA HVY54_17270 ENOG4108TSE Transferase HVY54_17285 ENOG4106KXD ATP-dependent carboxylate-amine ligase (By similarity) HVY54_17290 ENOG4105WQ6 Membrane HVY54_17295 ENOG4105MSB protein, conserved in bacteria HVY54_17300 ENOG4108RCM Nitroreductase HVY54_17305 ENOG4105CUY Mechanosensitive ion channel HVY54_17310 ENOG4105C85 amino acid HVY54_17315 ENOG4108IJF Heavy metal efflux pump, CzcA HVY54_17320 ENOG4105EP1 Efflux transporter rnd family, mfp subunit HVY54_17325 ENOG410624V efflux system protein HVY54_17330 ENOG4105ENJ RND efflux system, outer membrane lipoprotein HVY54_17335 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HVY54_17340 ENOG4105GR3 Histidine kinase HVY54_17350 ENOG41090FC Bacteriophage N4 receptor, outer membrane subunit HVY54_17355 ENOG4105QUW HVY54_17385 ENOG4108ZI2 Fimbrial protein HVY54_17390 ENOG4108M66 Involved in regulation of length and mediation of adhesion of SfmA fimbriae (but not necessary for the production of fimbriae). Seems to be mannose binding adhesin (By similarity) HVY54_17395 ENOG4105CW0 outer membrane usher protein HVY54_17400 ENOG4108AF8 Chaperone HVY54_17405 ENOG4108WDE Fimbrial protein HVY54_17415 ENOG4105WQ3 Rna-binding protein HVY54_17420 ENOG4105S2T inner membrane protein YbcI HVY54_17430 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) HVY54_17440 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) HVY54_17445 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit HVY54_17450 ENOG4105C5B carbamate kinase HVY54_17455 ENOG4105G5A Protein of unknown function (DUF2877) HVY54_17460 ENOG4107REC cytoplasmic protein HVY54_17465 ENOG4107R1Q Membrane protein FdrA HVY54_17470 ENOG4105DG4 malate L-lactate dehydrogenase HVY54_17475 ENOG4105CE7 Amidase, hydantoinase carbamoylase family HVY54_17480 ENOG4105S0E allantoin catabolism protein HVY54_17485 ENOG4105BZW Glycerate kinase HVY54_17490 ENOG4105DTE Xanthine uracil vitamin C permease HVY54_17500 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease HVY54_17505 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase HVY54_17510 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) HVY54_17515 ENOG41060W2 glyoxylate carboligase HVY54_17520 ENOG4108N16 Negative regulator of allantoin and glyoxylate utilization operons. Binds to the gcl promoter and to the allS- allA intergenic region HVY54_17530 ENOG4107653 Transcriptional regulator HVY54_17550 ENOG4105CNA YD repeat protein HVY54_17555 ENOG4105CV6 ABC transporter, permease HVY54_17560 ENOG4108I0Y (ABC) transporter HVY54_17565 ENOG4108UJV acyl-CoA thioesterase i HVY54_17570 ENOG4105E1F short-chain dehydrogenase reductase HVY54_17575 ENOG4107QR8 Thioredoxin HVY54_17580 ENOG4105C4B ABC transporter, permease HVY54_17585 ENOG41083J0 (ABC) transporter HVY54_17590 ENOG4107QX8 SPFH domain, Band 7 family protein HVY54_17595 ENOG4105G5H Membrane HVY54_17625 ENOG4107QZV Type I secretion membrane fusion protein HVY54_17630 ENOG4105BZ1 (ABC) transporter HVY54_17650 ENOG4107RY6 amino acid HVY54_17655 ENOG4105CSV Glutaminase HVY54_17660 ENOG4105C59 p-type ATPase HVY54_17665 ENOG41081XE plasmid maintenance system antidote protein, xre family HVY54_17670 ENOG4105MBR gumn family HVY54_17675 ENOG4108Z66 YbaK ebsC protein HVY54_17680 ENOG4105CGH 5'-nucleotidase HVY54_17685 ENOG4105EU0 Major facilitator Superfamily HVY54_17690 ENOG4105CKD glutathione-regulated potassium-efflux system protein HVY54_17695 ENOG4107RE1 Inosine-guanosine kinase HVY54_17730 ENOG4107QMP dna polymerase iii subunits gamma and tau HVY54_17740 ENOG4105WD1 Membrane HVY54_17745 ENOG4108URS primosomal replication protein n'' HVY54_17750 ENOG4106428 Protein of unknown function (DUF2496) HVY54_17755 ENOG4105EGS Mechanosensitive ion channel HVY54_17760 ENOG4107XI7 Tetr family transcriptional regulator HVY54_17765 ENOG4105C1P efflux transporter, rnd family, mfp subunit HVY54_17770 ENOG4105BZS acriflavin resistance protein HVY54_17775 ENOG4108UKR Biofilm formation regulator YbaJ HVY54_17780 ENOG4105KF5 hemolysin expression-modulating protein HVY54_17785 ENOG4108UW5 maltose o-acetyltransferase HVY54_17790 ENOG4105GSJ Inner membrane protein ylaC HVY54_17795 ENOG41066DG (EAL) domain protein HVY54_17800 ENOG4105KCV RNA signal recognition particle 4.5S RNA HVY54_17810 ENOG41080UX Methyltransferase HVY54_17815 ENOG4108MNP Glycoprotein polysaccharide metabolism HVY54_17820 ENOG4105C29 acyl-CoA thioesterase HVY54_17825 ENOG4105BZU Histidine kinase HVY54_17830 ENOG4108YZA Nitrogen regulatory protein pii HVY54_17835 ENOG4105BZ1 (ABC) transporter HVY54_17840 ENOG4105BZ1 (ABC) transporter HVY54_17845 ENOG4108XM1 transcriptional regulator AsnC family HVY54_17855 ENOG4108NFA extracellular solute-binding protein HVY54_17865 ENOG4108TGP Thioesterase superfamily protein HVY54_17870 ENOG41083P1 competence protein ComEA helix-hairpin-helix repeat protein HVY54_17875 ENOG4105EIN peptidylprolyl cis-trans isomerase HVY54_17880 ENOG4105K70 DNA-binding protein HVY54_17885 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) HVY54_17905 ENOG4105M85 Bola protein HVY54_17910 ENOG4105IEY (LipO)protein HVY54_17915 ENOG4105EYM Major Facilitator superfamily HVY54_17920 ENOG4105E2S oxidase) subunit II HVY54_17925 ENOG4105BZ9 Cytochrome C oxidase, subunit I HVY54_17930 ENOG4105CCU oxidase (Subunit III) HVY54_17935 ENOG41090KH cytochrome o ubiquinol oxidase (subunit iv) HVY54_17945 ENOG4107RDB Major Facilitator HVY54_17955 ENOG4108JZF Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) HVY54_17960 ENOG4107S0N DJ-1 family HVY54_17975 ENOG4105CTB Polyprenyl synthetase HVY54_17985 ENOG4105CPC Aldo Keto reductase HVY54_17995 ENOG4108ZAI phosphatidylglycerophosphatase a HVY54_18000 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) HVY54_18010 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) HVY54_18015 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) HVY54_18025 ENOG4108KIC (LipO)protein HVY54_18030 ENOG4105DRB nucleoside-specific channel-forming protein HVY54_18035 ENOG4105N1F Hnh endonuclease HVY54_18040 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) HVY54_18045 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) HVY54_18050 ENOG4105VIE preprotein translocase, subunit YajC HVY54_18075 ENOG4107R28 alpha amylase, catalytic region HVY54_18080 ENOG4105C85 amino acid HVY54_18085 ENOG4105CWM branched-chain amino acid transport system II carrier protein HVY54_18090 ENOG4105BZU Histidine kinase HVY54_18095 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HVY54_18100 ENOG4107RH8 nuclease SbcCD subunit D HVY54_18105 ENOG4105EYH Exonuclease HVY54_18110 ENOG4105F27 Major Facilitator HVY54_18115 ENOG4105DKQ ROK family HVY54_18140 ENOG4105HBA AroM protein HVY54_18145 ENOG4105SS3 HVY54_18160 ENOG4105II7 pyrroline-5-carboxylate reductase HVY54_18165 ENOG4105BZU Histidine kinase HVY54_18170 ENOG4105VIF phosphate starvation-inducible protein HVY54_18175 ENOG4105G6Z alkaline phosphatase HVY54_18190 ENOG4105CPF Cell wall formation (By similarity) HVY54_18195 ENOG4105UNH Membrane HVY54_18200 ENOG4105FR5 inner membrane protein YaiY HVY54_18205 ENOG4107QS8 (LipO)protein HVY54_18210 ENOG4108DQG in Escherichia coli SbmA is involved in uptake of microcin J25 HVY54_18215 ENOG4107R6D beta-lactam binding protein AmpH HVY54_18220 ENOG4108PNB DNA-binding transcriptional regulator HVY54_18230 ENOG4105D52 delta-aminolevulinic acid dehydratase HVY54_18235 ENOG4105E2B Taurine dioxygenase HVY54_18240 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component HVY54_18250 ENOG4106FTQ Taurine ABC transporter, periplasmic HVY54_18255 ENOG4108KX4 response regulator HVY54_18260 ENOG4105BZU Histidine kinase HVY54_18265 ENOG4105CXY transporter HVY54_18270 ENOG4105C4Y ABC transporter HVY54_18275 ENOG4107RCV ABC transporter, permease HVY54_18280 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HVY54_18295 ENOG4105C4W S-formylglutathione hydrolase HVY54_18300 ENOG4105IUQ nucleoprotein polynucleotide-associated enzyme HVY54_18305 ENOG4108SC4 )-transporter HVY54_18310 ENOG4105DF3 Catalyzes the retro-aldol cleavage of 4-hydroxy-2- oxopentanoate to pyruvate and acetaldehyde. Is involved in the meta-cleavage pathway for the degradation of aromatic compounds (By similarity) HVY54_18325 ENOG4106HB6 Alpha beta hydrolase HVY54_18340 ENOG4108K2P TRANSCRIPTIONal HVY54_18345 ENOG4105IGJ Zn-dependent Hydrolase of the beta-lactamase fold protein HVY54_18355 ENOG4105ETE Transcriptional regulator (LacI family HVY54_18360 ENOG4105CNT hydrolase family 2 HVY54_18365 ENOG4105U0F oligosaccharide H symporter, major facilitator superfamily (MFS) HVY54_18370 ENOG4108UW5 maltose o-acetyltransferase HVY54_18375 ENOG4105DJ2 Major Facilitator Superfamily HVY54_18385 ENOG4107B2H carbonic anhydrase HVY54_18390 ENOG4105DND Transcriptional regulator HVY54_18395 ENOG4105DZC cytosine deaminase HVY54_18400 ENOG4105DQW permease for cytosine purines, uracil, thiamine, allantoin HVY54_18405 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) HVY54_18410 ENOG4105DXD 2-methylcitrate dehydratase HVY54_18415 ENOG4105BZN citrate synthase HVY54_18420 ENOG4105CR4 methylisocitrate lyase HVY54_18425 ENOG4108JU7 Transcriptional regulator HVY54_18430 ENOG4105TDT uncharacterized protein yahO HVY54_18435 ENOG4105E82 cytochrome subunit of dehydrogenase HVY54_18450 ENOG4105DQ4 alcohol dehydrogenase HVY54_18455 ENOG4105CNN ABC, transporter HVY54_18460 ENOG4105CNN ABC, transporter HVY54_18465 ENOG4105C2J ABC transporter HVY54_18470 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator HVY54_18480 ENOG4105DZC cytosine deaminase HVY54_18485 ENOG4105C5B carbamate kinase HVY54_18495 ENOG4107REC cytoplasmic protein HVY54_18500 ENOG4107R1Q Membrane protein FdrA HVY54_18505 ENOG4105N16 Protein of unknown function (DUF2877) HVY54_18510 ENOG4107SNB ankyrin repeat protein YahD HVY54_18515 ENOG4105SZ2 membrAne HVY54_18520 ENOG4108NUU Transcriptional regulator HVY54_18525 ENOG4105BZU Histidine kinase HVY54_18535 ENOG4105C94 Transporter HVY54_18560 ENOG4105BZU Histidine kinase HVY54_18580 ENOG4108ZZK Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source (By similarity) HVY54_18585 ENOG4107QR9 Iron-sulfur cluster binding protein HVY54_18590 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) HVY54_18595 ENOG4108K01 transcriptional regulator HVY54_18600 ENOG4107QN2 dihydrolipoyl dehydrogenase HVY54_18605 ENOG41066GK UPF0379 protein ykgI HVY54_18610 ENOG4108KBJ Inner membrane protein YkgB HVY54_18650 ENOG4108GWT fimbrillin MatB HVY54_18660 ENOG4108N3D putative enzyme HVY54_18680 ENOG4105D7V transposase HVY54_18685 ENOG4105PI0 Ferredoxin HVY54_18690 ENOG4105R3P Inner membrane protein yagU HVY54_18695 ENOG4107XKX isoquinoline 1-oxidoreductase, alpha subunit HVY54_18700 ENOG4105DIP Molybdopterin dehydrogenase FAD-binding HVY54_18705 ENOG4105C7W Xanthine dehydrogenase HVY54_18710 ENOG4107XAN XdhC and CoxI family HVY54_18715 ENOG4107RTG Major Facilitator superfamily HVY54_18720 ENOG4105ENX hydrolase HVY54_18725 ENOG4105EQ2 LysR family Transcriptional regulator HVY54_18735 ENOG4105EMU Dehydrogenase HVY54_18750 ENOG4105CBN LysR family transcriptional regulator HVY54_18760 ENOG4108C33 Resolvase HVY54_18770 ENOG4105PTU response to oxidative stress HVY54_18775 ENOG4108US3 tail fiber assembly HVY54_18800 ENOG4108NKR DNA circulation protein HVY54_18820 ENOG4105H40 HVY54_18825 ENOG4108HJ1 Uncharacterized conserved protein (DUF2303) HVY54_18830 ENOG4108R7K Metal Dependent Phosphohydrolase HVY54_18835 ENOG41077V0 CPS-53 (KpLE1) prophage HVY54_18845 ENOG4108KU3 Integrase HVY54_18865 ENOG4105FCK Membrane HVY54_18875 ENOG4105V1F Fermentation respiration switch protein HVY54_18885 ENOG4105CIN aminoacyl-histidine dipeptidase HVY54_18890 ENOG4108S2Y peptide Chain Release factor HVY54_18900 ENOG4108HYG acetyltransferase HVY54_18905 ENOG4105UG9 Antitoxin of the YafO-YafN toxin-antitoxin system HVY54_18925 ENOG4108UK5 Transposase HVY54_18930 ENOG4108YS0 lipoprotein YafL HVY54_18940 ENOG4105VXN addiction module toxin, RelE StbE family HVY54_18945 ENOG4105F7V ErfK ybiS ycfS ynhG family protein HVY54_18950 ENOG4105E7A Glutamine amidotransferase HVY54_18960 ENOG4107QPN acyl-Coa dehydrogenase HVY54_18965 ENOG4108WN0 inhibitor of vertebrate lysozyme HVY54_18970 ENOG4105CZ7 nitrilase cyanide hydratase and apolipoprotein n-acyltransferase HVY54_19010 ENOG410600K aminopeptidase HVY54_19020 ENOG4107RZZ dna polymerase iii epsilon subunit HVY54_19030 ENOG4105D1A Methyltransferase HVY54_19035 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) HVY54_19040 ENOG4105E9H Lytic Murein transglycosylase HVY54_19045 ENOG4105F2W methyltransferase HVY54_19055 ENOG4105HEI LysR family (Transcriptional regulator HVY54_19060 ENOG4105CV8 reductase HVY54_19095 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase HVY54_19100 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) HVY54_19105 ENOG4108UMI ABC transporter, permease HVY54_19110 ENOG4105D01 (LipO)protein HVY54_19115 ENOG4108R8X outer membrane lipoprotein HVY54_19120 ENOG4108R96 Methyltransferase, YaeB family HVY54_19130 ENOG4108UY0 (LipO)protein HVY54_19135 ENOG4107EII Lipoprotein involved with copper homeostasis and adhesion HVY54_19140 ENOG4108YZN class I peptide chain release factor HVY54_19145 ENOG4108VWS Yaeq family HVY54_19155 ENOG4105M1T rho-binding antiterminator HVY54_19160 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) HVY54_19165 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase HVY54_19170 ENOG4105CXN decarboxylase HVY54_19180 ENOG4105C0B DNA polymerase III (alpha subunit) HVY54_19205 ENOG4105D7M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) HVY54_19210 ENOG4108RFI Molecular chaperone that interacts specifically with outer membrane proteins, thus maintaining the solubility of early folding intermediates during passage through the periplasm (By similarity) HVY54_19220 ENOG4105DZP Membrane-associated zinc metalloprotease HVY54_19225 ENOG4105KNE Phosphatidate cytidylyltransferase HVY54_19230 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) HVY54_19235 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) HVY54_19260 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) HVY54_19280 ENOG4108IXP Carbohydrate diacid transcriptional activator CdaR HVY54_19285 ENOG4105C0H protease HVY54_19300 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) HVY54_19305 ENOG4105EN6 Membrane HVY54_19330 ENOG4105S6R Iron-hydroxamate transporter permease subunit HVY54_19335 ENOG4105J76 Periplasmic binding protein HVY54_19340 ENOG4105E0A ABC, transporter HVY54_19345 ENOG4105E0K tonB-dependent siderophore receptor HVY54_19350 ENOG4105BZ4 penicillin-binding protein HVY54_19355 ENOG4105CQ7 ATP-dependent helicase HVY54_19360 ENOG4107XID 2'-5' rna ligase HVY54_19375 ENOG4106F3G Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity) HVY54_19380 ENOG4105DJ0 Poly(A) Polymerase HVY54_19385 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase HVY54_19395 ENOG4108VEV chaperone HVY54_19400 ENOG4105CW0 outer membrane usher protein HVY54_19405 ENOG4108XEY fimbrial-like adhesin protein HVY54_19410 ENOG4105SYG Fimbrial protein HVY54_19435 ENOG4108A32 Transposase HVY54_19445 ENOG4107BJW polysaccharide deacetylase HVY54_19450 ENOG4108YTN IIa component HVY54_19455 ENOG4105E3A (ABC) transporter HVY54_19460 ENOG4105DA5 (ABC) transporter HVY54_19465 ENOG41077A9 carbonic anhydrase HVY54_19470 ENOG4108UGV hypoxanthine phosphoribosyltransferase HVY54_19475 ENOG4105DZG Dehydrogenase HVY54_19480 ENOG4105E3B Multicopper oxidase HVY54_19485 ENOG4108ZRK uncharacterized protein yacC HVY54_19505 ENOG4107QIJ Aconitate hydratase 2 HVY54_19510 ENOG4108NST exported protein HVY54_19515 ENOG4107QN2 dihydrolipoyl dehydrogenase HVY54_19520 ENOG4107QSN dihydrolipoamide acetyltransferase HVY54_19525 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) HVY54_19530 ENOG41073TP transcriptional regulator HVY54_19535 ENOG4105C85 amino acid HVY54_19540 ENOG4106A72 regulatory protein AmpE HVY54_19545 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase HVY54_19550 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase HVY54_19555 ENOG4108ZUW Major pilin subunit HVY54_19560 ENOG4107QHF type ii secretion system protein e HVY54_19565 ENOG4105D7Q type ii secretion system HVY54_19580 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) HVY54_19595 ENOG4105M6F mutator MutT protein HVY54_19615 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) HVY54_19620 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) HVY54_19625 ENOG4105K7E Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity) HVY54_19630 ENOG4105CPF Cell wall formation (By similarity) HVY54_19645 ENOG4105CNI cell division protein FtsW HVY54_19650 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) HVY54_19660 ENOG4108EQQ Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity) HVY54_19665 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) HVY54_19670 ENOG4105CJN penicillin-binding protein HVY54_19675 ENOG41063Y6 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) HVY54_19690 ENOG4107B7Y DNA-binding transcriptional regulator FruR HVY54_19700 ENOG4108ZP8 Acetolactate synthase small subunit HVY54_19705 ENOG4105C7K acetolactate synthase HVY54_19710 ENOG41064T2 transcriptional regulator, lysR family HVY54_19755 ENOG4105DP9 ABC transporter HVY54_19760 ENOG4106SMU thiamine transporter membrane protein HVY54_19770 ENOG4108KF1 Membrane HVY54_19775 ENOG41063TF transcriptional regulator (AraC HVY54_19790 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase HVY54_19795 ENOG4105CQ2 DNA polymerase HVY54_19800 ENOG4105BZK Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair (By similarity) HVY54_19805 ENOG4105D3G Pseudouridine synthase HVY54_19810 ENOG41066UG Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host (By similarity) HVY54_19815 ENOG4105E7H involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity) HVY54_19820 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) HVY54_19855 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) HVY54_19860 ENOG4105CKD glutathione-regulated potassium-efflux system protein HVY54_19870 ENOG4105C54 Major Facilitator superfamily HVY54_19875 ENOG4105IBM Could be part of an electron transfer system required for anaerobic carnitine reduction. Could be a 3Fe-4S cluster- containing protein HVY54_19880 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase HVY54_19895 ENOG4105C94 Transporter HVY54_19915 ENOG4106YT9 Enoyl-CoA hydratase HVY54_19925 ENOG4108XNW Transcriptional activatory protein CaiF HVY54_19930 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain HVY54_19935 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain HVY54_19955 ENOG41090X3 Peptidyl-prolyl cis-trans isomerase HVY54_19965 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) HVY54_19970 ENOG4105DTN riboflavin biosynthesis protein ribF HVY54_19975 ENOG410647N response to DNA damage stimulus HVY54_19995 ENOG4108MQF Chaperone HVY54_20000 ENOG4105CW0 outer membrane usher protein HVY54_20010 ENOG41063Z6 transcriptional regulator, lysR family HVY54_20020 ENOG4105WI6 cell killing protein encoded within cryptic prophage HVY54_20040 ENOG4108QUJ UPF0174 protein YaaW HVY54_20045 ENOG4106HK8 GPR1 FUN34 yaaH family protein HVY54_20050 ENOG4108RIR Molybdenum cofactor biosynthesis protein HVY54_20055 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) HVY54_20060 ENOG4105BZG amino acid carrier protein HVY54_20070 ENOG41062C6 Protein of unknown function (DUF2502) HVY54_20075 ENOG4105D98 threonine synthase HVY54_20085 ENOG4105CFH Aspartokinase HVY54_20095 ENOG4106FVC RNA methyltransferase HVY54_20100 ENOG410759A HVY54_20105 ENOG41065U4 response regulator HVY54_20110 ENOG4105CT7 inner membrane cred family protein HVY54_20115 ENOG4105EB3 Histidine kinase HVY54_20120 ENOG4105E3W Two component transcriptional regulator (Winged helix family HVY54_20125 ENOG4108RH0 Crea protein HVY54_20130 ENOG4105UEI Transcriptional Regulator AraC Family HVY54_20150 ENOG4107SC1 transglycosylase HVY54_20155 ENOG4105C5H ABC transporter HVY54_20160 ENOG4107VZS Nicotinamide-nucleotide adenylyltransferase HVY54_20165 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) HVY54_20170 ENOG4105EAC phosphoserine phosphatase HVY54_20175 ENOG41062Z9 Membrane HVY54_20210 ENOG4105G0K glycine radical enzyme YjjI family HVY54_20215 ENOG41076CZ activating enzyme HVY54_20220 ENOG4105EYA deoxyribonuclease HVY54_20225 ENOG4108NRW Phospholipase, patatin family HVY54_20235 ENOG4105K3G Periplasmic Protein HVY54_20245 ENOG4105PAD Hydrolase HVY54_20250 ENOG4105KEG ribosomal-protein-alanine acetyltransferase HVY54_20255 ENOG4108WPU DNA polymerase III subunit psi HVY54_20260 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) HVY54_20280 ENOG4105YBH Protein of unknown function (DUF1435) HVY54_20285 ENOG4108819 ferric iron reductase HVY54_20290 ENOG4108T94 DNA-binding transcriptional activator BglJ HVY54_20295 ENOG4108N8T regulatoR HVY54_20300 ENOG4105DWK Membrane HVY54_20305 ENOG4107XM3 UPF0442 protein HVY54_20315 ENOG4106CVF DNA replication protein HVY54_20320 ENOG4105RI1 glycoprotein receptor HVY54_20330 ENOG4105CPQ Dehydrogenase HVY54_20335 ENOG410617M Transcriptional regulator HVY54_20340 ENOG4108I5G Major Facilitator superfamily HVY54_20345 ENOG4105C8Q Methyl-accepting chemotaxis HVY54_20355 ENOG4105D22 carbon starvation protein HVY54_20360 ENOG4105VCD cytoplasmic protein HVY54_20365 ENOG4105CKI cobalamin synthesis protein HVY54_20375 ENOG4108F3G Type I restriction-modification system, R subunit HVY54_20385 ENOG4107QTH restriction modification system DNA specificity domain HVY54_20400 ENOG4106DIZ Domain of unknown function (DUF1127) HVY54_20405 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HVY54_20415 ENOG41083G8 Multidrug resistance protein MdtM HVY54_20420 ENOG4106BRA Membrane HVY54_20425 ENOG4105DCU 2-hydroxyglutaryl-CoA dehydratase HVY54_20430 ENOG4105CIZ coA-substrate-specific enzyme activase HVY54_20445 ENOG4108ZK4 sdia-regulated domain-containing protein HVY54_20450 ENOG4105CBP Major Facilitator HVY54_20465 ENOG41074DU domain protein HVY54_20470 ENOG4108P2H Inner membrane protein YjiG HVY54_20475 ENOG4105DYB Isoaspartyl dipeptidase HVY54_20480 ENOG4107YNJ LysR family Transcriptional regulator HVY54_20500 ENOG4105C6F GntR Family Transcriptional Regulator HVY54_20505 ENOG4105DEI Mannitol dehydrogenase HVY54_20520 ENOG410643X FIMH SUBUNIT MANNOSE-sensitive type 1 fimbrial adhesin HVY54_20525 ENOG4108T65 Fimbrial HVY54_20530 ENOG4108SQA Fimbrial HVY54_20535 ENOG4105CW0 outer membrane usher protein HVY54_20540 ENOG4108NAE Fimbrial chaperone protein HVY54_20545 ENOG4108S54 Fimbrial protein HVY54_20550 ENOG4108RQP Major type 1 subunit fimbrin HVY54_20555 ENOG4105E71 FimE is one of the 2 regulatory proteins which control the phase variation of type 1 fimbriae in E.coli. These proteins mediate the periodic inversion of a 300bp DNA segment that harbors the promoter for the fimbrial structural gene, fimA. FimE switches fimA off HVY54_20560 ENOG4108W9T type 1 fimbriae regulatory protein HVY54_20565 ENOG41069FU Outer membrane channel protein allowing the entry of N- acetylneuraminic acid (Neu5Ac, the most abundant sialic acid on host cell surfaces) into the bacteria HVY54_20570 ENOG4108MX5 Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses (By similarity) HVY54_20625 ENOG4105DSG hydrolase family 43 HVY54_20630 ENOG4105CT4 transporter HVY54_20635 ENOG4105C93 Xylose Isomerase HVY54_20640 ENOG4108KDD Involved in the transport of maltose and maltodextrins (By similarity) HVY54_20685 ENOG4105T40 surface antigen msp4 family protein HVY54_20690 ENOG4108I6E Sulfatase HVY54_20705 ENOG4105DQ4 alcohol dehydrogenase HVY54_20710 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family HVY54_20715 ENOG4105CPQ Dehydrogenase HVY54_20720 ENOG4105CHR reductase HVY54_20725 ENOG4105C6Z Gluconate HVY54_20730 ENOG4105K2J Transcriptional regulator HVY54_20735 ENOG4105D7A ATP-binding protein HVY54_20740 ENOG4108K5H permease YjgP YjgQ family protein HVY54_20745 ENOG4108M8S permease YjgP YjgQ family protein HVY54_20755 ENOG4105MYG DNA polymerase iii, chi subunit HVY54_20765 ENOG4108M3P Membrane HVY54_20770 ENOG4108MJ3 acetyltransferase HVY54_20775 ENOG4105KQT Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome (By similarity) HVY54_20790 ENOG4105XEP YhcH YjgK YiaL family protein HVY54_20795 ENOG4108XFH Transcriptional regulator HVY54_20800 ENOG4105F6U Short-chain dehydrogenase reductase Sdr HVY54_20805 ENOG4108UQ8 endoribonuclease L-psp HVY54_20810 ENOG4107C93 pyrBI operon leader peptide HVY54_20825 ENOG4105KME endoribonuclease L-psp HVY54_20830 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic HVY54_20840 ENOG4105D4X repressor HVY54_20845 ENOG4105C5Y PTS System HVY54_20850 ENOG4105CG3 alpha amylase, catalytic region HVY54_20855 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase HVY54_20860 ENOG4108RDD Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine (By similarity) HVY54_20875 ENOG4105CMS peptidase U62, modulator of DNA gyrase HVY54_20885 ENOG4105DFU Cell wall formation (By similarity) HVY54_20895 ENOG41062B0 ABC transporter, permease HVY54_20900 ENOG4107R9N ABC transporter HVY54_20905 ENOG4105C2J ABC transporter HVY54_20910 ENOG4107R5U Periplasmic binding protein LacI transcriptional regulator HVY54_20915 ENOG4105F0N pyrophosphate phospho-hydrolase HVY54_20920 ENOG4105MZG transcriptional modulator of maze toxin, mazf HVY54_20925 ENOG41087RY SpoVT_AbrB HVY54_20930 ENOG4108ZHD aig2 family HVY54_20935 ENOG4105MA0 exported protein HVY54_20940 ENOG4105CFU surface antigen HVY54_20950 ENOG4105C37 (CBS) domain HVY54_20955 ENOG41061GZ Protein of unknown function (DUF1107) HVY54_20960 ENOG4108UUE Transcriptional regulator HVY54_20970 ENOG4108RNI 3'(2')5'-bisphosphate nucleotidase HVY54_20975 ENOG4107RNS bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase 3'-nucleotidase periplasmic HVY54_20980 ENOG4105KVH Transcriptional regulator HVY54_20985 ENOG4105ECR NmrA family HVY54_20990 ENOG4105DXC membrane HVY54_21000 ENOG4105C85 amino acid HVY54_21005 ENOG4108V1T peptidylprolyl cis-trans isomerase HVY54_21010 ENOG4105FHY Opacity-associated protein A HVY54_21020 ENOG4105D7V transposase HVY54_21025 ENOG4108RS6 transposase HVY54_21045 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) HVY54_21060 ENOG4105KIT UPF0379 protein yjfY HVY54_21080 ENOG4106ETB IIa component HVY54_21085 ENOG410907W The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in ascorbate transport HVY54_21090 ENOG4105CZC PTS system ascorbate-specific transporter subunit IIC HVY54_21105 ENOG4108MXZ Esterase HVY54_21110 ENOG4105WSB biofilm stress and motility protein A HVY54_21115 ENOG4105S17 UPF0379 protein yjfN HVY54_21120 ENOG4105CSU acyl-Coa dehydrogenase HVY54_21125 ENOG4106032 Glutathionylspermidine synthase HVY54_21130 ENOG4108KXT Conserved Protein HVY54_21135 ENOG4105Z6B inner membrane protein yjfl HVY54_21140 ENOG4107VNS Protein of unknown function (DUF2491) HVY54_21145 ENOG4108P9J Phage shock protein A HVY54_21150 ENOG4105FUX Conserved Protein HVY54_21155 ENOG4105C2N RNA methyltransferase TrmH family group 3 HVY54_21160 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) HVY54_21180 ENOG4105EPW hflc protein HVY54_21185 ENOG4107QJR hflk protein HVY54_21190 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) HVY54_21210 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase HVY54_21215 ENOG4105K8N protein family UPF0079, ATPase HVY54_21220 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) HVY54_21265 ENOG4105EGS Mechanosensitive ion channel HVY54_21270 ENOG4106CG8 Inner membrane protein YjeO HVY54_21275 ENOG4107SC7 Inner membrane transporter yjeM HVY54_21280 ENOG4105CAP With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P (By similarity) HVY54_21285 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) HVY54_21290 ENOG4105E33 succinate dehydrogenase HVY54_21305 ENOG41066YJ Beta-lactamase HVY54_21310 ENOG4105QNF Outer membrane lipoprotein HVY54_21315 ENOG4105KPY Small multidrug resistance protein HVY54_21320 ENOG4106BSU Entericidin B HVY54_21325 ENOG4107PEH Entericidin EcnA/B family HVY54_21335 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein HVY54_21340 ENOG4105MTB Uncharacterized protein YjeJ HVY54_21345 ENOG4108ZVF (LipO)protein HVY54_21360 ENOG4105DVH amino acid HVY54_21365 ENOG4108YH1 overproduction of this protein in Escherichia coli inhibits the F plasmid-mediated exclusion of bacteriophage T7 HVY54_21370 ENOG4108IJ0 Aspartate ammonia-lyase HVY54_21375 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter HVY54_21385 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) HVY54_21390 ENOG4108SIC Transcriptional regulator HVY54_21410 ENOG4105PV3 Inner membrane protein yqiJ HVY54_21420 ENOG4108MY7 Fimbrial HVY54_21425 ENOG4108TTM chaperone HVY54_21440 ENOG41060ND LF82 chromosome, complete sequence HVY54_21450 ENOG4105C4R Atp-dependent dna helicase HVY54_21455 ENOG4108I5C dEAD DEAH box helicase HVY54_21465 ENOG4105BZK Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair (By similarity) HVY54_21475 ENOG4105F2I Transposase HVY54_21485 ENOG4105T40 surface antigen msp4 family protein HVY54_21530 ENOG4108SAU DNA-binding protein H-ns HVY54_21565 ENOG4105TS0 gtp-binding protein HVY54_21580 ENOG4106H6R UPF0380 protein HVY54_21585 ENOG4105MFG Antirestriction protein HVY54_21590 ENOG4108YGG dna repair protein HVY54_21600 ENOG4105MAW Antitoxin component of a toxin-antitoxin (TA) module. Labile antitoxin that counteracts the effect of the CbtA (YeeV) toxin. It does not bind to the cognate toxin but instead binds to MreB and FtsZ (the toxin targets), enhancing their polymerization by forming higher-order bundles HVY54_21625 ENOG4108M3R transcriptional activator CadC HVY54_21630 ENOG4105D5Q Arginine ornithine antiporter HVY54_21635 ENOG4105CXN decarboxylase HVY54_21640 ENOG4105DUX Transporter HVY54_21645 ENOG4105CRK lysyL-tRNA synthetase HVY54_21660 ENOG410830R acetyltransferase HVY54_21665 ENOG4105VR1 Pfam:DUF1271 HVY54_21670 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism HVY54_21675 ENOG4108MRH transcriptional regulatory protein HVY54_21680 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter HVY54_21685 ENOG4107GFK fumarate HVY54_21690 ENOG4108R5S membrane HVY54_21695 ENOG4105CT4 transporter HVY54_21700 ENOG4105F8D glycoside hydrolase family 4 HVY54_21705 ENOG4108K2B transcriptional regulator HVY54_21710 ENOG4105CXN decarboxylase HVY54_21715 ENOG4106ZGR Transcriptional regulator HVY54_21720 ENOG4105D5Q Arginine ornithine antiporter HVY54_21725 ENOG4105DIJ Phosphoethanolamine transferase HVY54_21730 ENOG4105XJC Two component transcriptional regulator (Winged helix family HVY54_21735 ENOG4105ECM Sensor protein basS pmrB HVY54_21745 ENOG4105CSH Transporter HVY54_21750 ENOG4108YIV HVY54_21755 ENOG4108F5E vimentin HVY54_21760 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA HVY54_21765 ENOG4108SQ4 Glyoxalase Bleomycin resistance protein (Dioxygenase HVY54_21775 ENOG4105EHI Phosphonate ABC transporter, periplasmic HVY54_21785 ENOG4107RJJ Transcriptional regulator HVY54_21790 ENOG4105KQZ Phosphonate C-P lyase system protein PhnG HVY54_21795 ENOG4105KZ6 phosphonate C-P lyase system protein PhnH HVY54_21800 ENOG4105EKV Phosphonate metabolism protein HVY54_21805 ENOG4105FT8 Phosphonate metabolism HVY54_21810 ENOG4105ENV phosphonate C-P lyase system protein PhnK HVY54_21815 ENOG4105HRV phosphonate c-p lyase system protein phnl HVY54_21820 ENOG4105FD8 phosphonate metabolism protein PhnM HVY54_21825 ENOG4105MFQ Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP) (By similarity) HVY54_21830 ENOG410849A acetyltransferase, (GNAT) family HVY54_21835 ENOG4107SA6 carbon-phosphorus lyase complex accessory protein HVY54_21840 ENOG4106ZVZ Escherichia coli IMT2125 genomic chromosome, IMT2125 HVY54_21850 ENOG4105C2J ABC transporter HVY54_21855 ENOG4105CNN ABC, transporter HVY54_21860 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator HVY54_21870 ENOG4105D2N Aldolase HVY54_21885 ENOG4105EUZ Beta-lactamase domain protein HVY54_21895 ENOG4105J12 Multidrug resistance protein mdtN HVY54_21900 ENOG4108MI0 Resistance protein HVY54_21915 ENOG41082ND Uncharacterized protein yjcO HVY54_21920 ENOG4105CK2 sodium dicarboxylate symporter HVY54_21925 ENOG4108W0S formate-dependent nitrite reductase complex HVY54_21935 ENOG4108QKW cytochrome c-type biogenesis protein HVY54_21940 ENOG4105DVI reductase, NrfD HVY54_21945 ENOG4105D3S 4Fe-4S Ferredoxin, iron-sulfur binding domain protein HVY54_21950 ENOG4105JJ8 Cytochrome c nitrite reductase, pentaheme subunit HVY54_21960 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) HVY54_21965 ENOG41062QD Membrane HVY54_21980 ENOG4105EEQ Na H antiporter HVY54_21985 ENOG4105C7N Xanthine uracil vitamin C permease HVY54_21990 ENOG4108Z4X TRANSCRIPTIONal HVY54_21995 ENOG4108W3Q Transcriptional regulator HVY54_22000 ENOG4108M8H domain protein HVY54_22005 ENOG4105PMV Membrane HVY54_22010 ENOG4108UUM single-stranded DNA-binding protein HVY54_22015 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) HVY54_22020 ENOG4105MSB protein, conserved in bacteria HVY54_22025 ENOG4108YXI Secondary thiamine-phosphate synthase enzyme HVY54_22030 ENOG4105F0S class B acid phosphatase HVY54_22040 ENOG4105CGF Aromatic amino acid aminotransferase HVY54_22050 ENOG4106Z1T Nicotinamide Mononucleotide Transporter HVY54_22055 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) HVY54_22060 ENOG4105CDU Replicative dna helicase HVY54_22065 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein HVY54_22070 ENOG4105P4Z Phage shock protein G HVY54_22075 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) HVY54_22085 ENOG4105MYN Zinc uptake regulation protein HVY54_22090 ENOG4105VDW Csbd family HVY54_22095 ENOG4107R73 Mate efflux family protein HVY54_22105 ENOG41080IJ Diacylglycerol kinase HVY54_22130 ENOG4107W52 maltose operon periplasmic protein HVY54_22140 ENOG4108IJ9 (ABC) transporter HVY54_22145 ENOG4107FKK extracellular solute-binding protein family 1 HVY54_22150 ENOG4105D56 permease protein HVY54_22155 ENOG4105EG2 ABC transporter, permease HVY54_22160 ENOG4107QNK )-transporter HVY54_22180 ENOG4105E3R (LipO)protein HVY54_22185 ENOG4108Q9C Periplasmic Protein HVY54_22190 ENOG4108MDC (LipO)protein HVY54_22200 ENOG4107QP8 phosphohexose isomerase HVY54_22205 ENOG4105CFH Aspartokinase HVY54_22210 ENOG4108ZR5 Conserved Protein HVY54_22215 ENOG4105FE9 pseudouridine synthase HVY54_22220 ENOG4105DKT Transcriptional regulator HVY54_22225 ENOG4105CHR reductase HVY54_22230 ENOG4108XCU pts system HVY54_22235 ENOG4105KPI PTS system sorbose subfamily IIB component HVY54_22240 ENOG4105ETZ PTS System HVY54_22245 ENOG4105F3R pts system mannose fructose sorbose family iid HVY54_22250 ENOG4105DXH Alcohol dehydrogenase zinc-binding domain protein HVY54_22260 ENOG4105EAM Na Pi-cotransporter HVY54_22265 ENOG4105C3R Methionine synthase HVY54_22270 ENOG41069M3 Transcriptional regulator HVY54_22285 ENOG4108I9X Isocitrate lyase HVY54_22290 ENOG4107QP3 malate synthase g HVY54_22300 ENOG4105K5X acetyltransferase HVY54_22330 ENOG4105C12 Phosphoribosylglycinamide synthetase HVY54_22335 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family HVY54_22340 ENOG4105BZU Histidine kinase HVY54_22345 ENOG4105JBU Binds zinc. Could be an important component of the zinc- balancing mechanism HVY54_22350 ENOG4108T8B Protein of unknown function (DUF1481) HVY54_22360 ENOG4105R2J Conserved Protein HVY54_22385 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) HVY54_22395 ENOG4105D06 uba thif-type nad fad binding protein HVY54_22400 ENOG4105WHD thiamine biosynthesis protein ThiS HVY54_22405 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) HVY54_22410 ENOG4105D41 biosynthesis protein thiH HVY54_22415 ENOG410645W Thiamin biosynthesis protein ThiH HVY54_22450 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) HVY54_22455 ENOG4105PM1 preprotein translocase subunit SecE HVY54_22490 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase HVY54_22525 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) HVY54_22530 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) HVY54_22535 ENOG4107R9T Catalyzes the formation of 5-methyl-uridine at position 54 (m5U54) in all tRNAs (By similarity) HVY54_22540 ENOG4108Y73 Membrane HVY54_22545 ENOG4105EJ2 Transcriptional regulator HVY54_22555 ENOG4105CH2 amidohydrolase HVY54_22565 ENOG4105C5Q Transcriptional regulator HVY54_22580 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase HVY54_22595 ENOG4105DIJ Phosphoethanolamine transferase HVY54_22600 ENOG4106R3P AraC family transcriptional regulator HVY54_22605 ENOG4108XCZ PTS System HVY54_22610 ENOG4108AHH pyruvate formate lyase II activase HVY54_22620 ENOG4108YRF PTS System HVY54_22625 ENOG4105DM4 PTS System HVY54_22630 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) HVY54_22635 ENOG4107T9Z Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) HVY54_22640 ENOG4105DCT glycerol dehydrogenase HVY54_22645 ENOG4108XC3 NADH ubiquinone oxidoreductase HVY54_22650 ENOG4108Q5Y Membrane HVY54_22660 ENOG4105SYT Methylenetetrahydrofolate reductase HVY54_22670 ENOG4105CFH Aspartokinase HVY54_22675 ENOG4105C28 cystathionine HVY54_22685 ENOG4107S01 Repressor protein MetJ HVY54_22710 ENOG4105C25 Primosomal protein n' HVY54_22715 ENOG4105ETE Transcriptional regulator (LacI family HVY54_22720 ENOG41063M6 Cell Division Protein HVY54_22735 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase HVY54_22760 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) HVY54_22770 ENOG4105CBT Fructose-1,6-bisphosphatase HVY54_22775 ENOG4105DP0 ferredoxin-NADP reductase HVY54_22785 ENOG41065TG regulatoR HVY54_22790 ENOG4108VTS Membrane HVY54_22795 ENOG4105EBK exported protein HVY54_22810 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein HVY54_22825 ENOG4105FMW periplasmic HVY54_22830 ENOG4105E3W Two component transcriptional regulator (Winged helix family HVY54_22835 ENOG4105E0F Histidine kinase HVY54_22840 ENOG4108RPX mosc domain containing protein HVY54_22850 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) HVY54_22860 ENOG4108BRW Activates expression of the rhaSR operon in response to L-rhamnose (By similarity) HVY54_22895 ENOG41064BA PTS system, fructose-specific, IIA component HVY54_22900 ENOG4105DM4 PTS System HVY54_22905 ENOG4105CN9 Peptidase m42 family protein HVY54_22910 ENOG4106C3V frv operon regulatory protein HVY54_22915 ENOG4108V87 frv operon regulatory protein HVY54_22930 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein HVY54_22935 ENOG4108MG3 formate dehydrogenase HVY54_22945 ENOG41068KX affects formate dehydrogenase-N HVY54_22960 ENOG4105SUU thioesterase domain HVY54_22975 ENOG4105EJU HAD-superfamily hydrolase subfamily IA variant 3 HVY54_22980 ENOG4105E98 transcriptional regulator DeoR family HVY54_22985 ENOG4108MGF sugar kinase HVY54_22990 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase HVY54_22995 ENOG4105D2M Aldolase HVY54_23000 ENOG4107QKS N-acylglucosamine 2-epimerase HVY54_23005 ENOG4107WI4 Aldose-1-epimerase HVY54_23015 ENOG4105CJQ hydrolase, family 31 HVY54_23020 ENOG4105CT4 transporter HVY54_23025 ENOG4105CT4 transporter HVY54_23030 ENOG4108KUC Outer membrane channel protein that allows an efficient diffusion of low-molecular-weight solutes such as small sugars and tetraglycine. However, the specific substrate recognized by the OmpL channel is HVY54_23035 ENOG4105R9B Major Facilitator HVY54_23040 ENOG4108KHF Resistance protein HVY54_23045 ENOG4108K85 Transcriptional regulator HVY54_23050 ENOG4105CI3 gtp-binding protein typa HVY54_23055 ENOG4105C5F glutamine synthetase HVY54_23060 ENOG4105CUX Signal transduction histidine kinase HVY54_23065 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family HVY54_23070 ENOG4106FIY HVY54_23075 ENOG4105D4P Coproporphyrinogen iii oxidase HVY54_23080 ENOG4105ZR3 A GTPase-activating protein (GAP) that modifies Der EngA GTPase function. May play a role in ribosome biogenesis (By similarity) HVY54_23090 ENOG4105C2M dna polymerase I HVY54_23095 ENOG4106HNH Acyl-transferase HVY54_23105 ENOG4108Z33 Thiol disulfide Interchange Protein HVY54_23110 ENOG4105E27 serine threonine protein kinase HVY54_23115 ENOG4105PC1 Conserved Protein HVY54_23120 ENOG4105C6R Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) HVY54_23125 ENOG4105FNP Molybdopterin-guanine dinucleotide biosynthesis protein b HVY54_23150 ENOG4108RR8 protoporphyrinogen oxidase HVY54_23155 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) HVY54_23160 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein HVY54_23180 ENOG4108EX3 reductase HVY54_23185 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) HVY54_23190 ENOG4105MDZ Transcriptional activator rfaH HVY54_23195 ENOG4105F8V Hydrolase, tatD family HVY54_23200 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) HVY54_23205 ENOG4105X8U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity) HVY54_23210 ENOG4105WKS Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) HVY54_23220 ENOG4105JC1 sterol-binding domain protein HVY54_23230 ENOG4105CGY Dna recombination protein HVY54_23235 ENOG4108I5U Uridine phosphorylase HVY54_23240 ENOG4105CDZ Carboxymethylenebutenolidase (EC 3.1.1.45) HVY54_23250 ENOG4105DZ2 Transcriptional regulator HVY54_23255 ENOG4105EMK carboxylate amino acid amine transporter HVY54_23260 ENOG4105DQF Hydrolase HVY54_23265 ENOG4108EUD Lysophospholipase HVY54_23270 ENOG410829K Lysine exporter protein (Lyse ygga) HVY54_23275 ENOG4105CCF Lysine exporter protein (Lyse ygga) HVY54_23280 ENOG4105C9U ATP-dependent DNA helicase RecQ HVY54_23285 ENOG4105HDD phospholipase HVY54_23290 ENOG4108VUY thioesterase Superfamily protein HVY54_23295 ENOG4105FR1 rard protein HVY54_23300 ENOG4106WR8 Inner membrane protein YigG HVY54_23305 ENOG4105NRM Membrane HVY54_23310 ENOG4107QUT magnesium and cobalt transport protein CorA HVY54_23315 ENOG4108T58 Mg2 transport protein CorA HVY54_23320 ENOG4107V4F S-adenosyl-l-methionine hydroxide adenosyltransferase HVY54_23325 ENOG4105C4R Atp-dependent dna helicase HVY54_23330 ENOG4105DFC had-superfamily hydrolase, subfamily ia, variant HVY54_23340 ENOG4105CT0 Protein of unknown function, DUF484 HVY54_23350 ENOG4105S7Z (LipO)protein HVY54_23360 ENOG4107T0K Adenylate cyclase HVY54_23370 ENOG41076E6 Uroporphyrinogen-III Synthase HVY54_23375 ENOG4105ECF c-methyltransferase HVY54_23380 ENOG410601J HemY protein HVY54_23385 ENOG4105ENH Sulfatase HVY54_23390 ENOG4105C4X radical SAM domain protein HVY54_23415 ENOG4105C85 amino acid HVY54_23435 ENOG4105EGZ biosynthesis protein HVY54_23440 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase HVY54_23445 ENOG4108WJ1 acetyltransferase HVY54_23450 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) HVY54_23455 ENOG4105C1B dTDP-glucose 4-6-dehydratase HVY54_23460 ENOG4107QQG Dehydrogenase HVY54_23465 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase HVY54_23470 ENOG4105SFE lipopolysaccharide biosynthesis protein HVY54_23475 ENOG4105ESV Glycosyl transferase, family 4 HVY54_23480 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) HVY54_23505 ENOG4105C4R Atp-dependent dna helicase HVY54_23515 ENOG4105KQ5 peptidylprolyl cis-trans isomerase HVY54_23525 ENOG4105EMY transcriptional regulator HVY54_23530 ENOG4105C7B Threonine dehydratase HVY54_23540 ENOG4105CM2 brancheD-chain amino acid aminotransferase HVY54_23545 ENOG4105P3Y Acetolactate synthase 2 regulatory subunit HVY54_23565 ENOG4105C0P Mg chelatase subunit ChlI HVY54_23570 ENOG4108WFC UPF0438 protein yifE HVY54_23610 ENOG4107EJG GntR family transcriptional regulator HVY54_23615 ENOG4105C0R drug resistance transporter emrb qaca subfamily HVY54_23620 ENOG4105ETE Transcriptional regulator (LacI family HVY54_23625 ENOG4108RVA ribokinase HVY54_23630 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator HVY54_23635 ENOG4105CNN ABC, transporter HVY54_23640 ENOG4105C2J ABC transporter HVY54_23645 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) HVY54_23660 ENOG4105EV2 VWA domain protein interacting with AAA ATPase HVY54_23670 ENOG4108VVK transcriptional Regulator, AsnC HVY54_23675 ENOG4105QTB Flavodoxin HVY54_23690 ENOG4105GXX Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit I associates with the membrane and may be involved with cation translocation HVY54_23740 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) HVY54_23750 ENOG4108NAE Fimbrial chaperone protein HVY54_23755 ENOG4105CW0 outer membrane usher protein HVY54_23765 ENOG4107QMV Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity) HVY54_23770 ENOG4105C8U phosphate abc transporter HVY54_23775 ENOG4105E2Z phosphate ABC transporter (Permease HVY54_23780 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) HVY54_23785 ENOG4108UTW Plays a role in the regulation of phosphate uptake HVY54_23810 ENOG4107UB3 HAD-superfamily hydrolase subfamily IA variant 3 HVY54_23815 ENOG4105C7N Xanthine uracil vitamin C permease HVY54_23820 ENOG4108YYH Nadph-dependent fmn reductase HVY54_23825 ENOG4105E8Q phosphopantetheinyl transferase HVY54_23840 ENOG4108P6C Tryptophan transporter of low affinity HVY54_23865 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins HVY54_23880 ENOG4105VG0 50S ribosomal protein l34 HVY54_23970 ENOG4105BZS acriflavin resistance protein HVY54_23985 ENOG4105MN3 Resolvase HVY54_24035 ENOG4107EFR Flavocytochrome c HVY54_24045 ENOG4106CQM replication HVY54_24095 ENOG4105M0J Toxic component of a toxin-antitoxin (TA) module. A HVY54_24235 ENOG4105EJX conjugal transfer ATPase HVY54_24295 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) HVY54_24340 ENOG4108KTG Membrane protein, drug metabolite transporter HVY54_24365 ENOG4108BUD transposase HVY54_24380 ENOG4108BUD transposase HVY54_24390 ENOG4105VFQ Histone family protein nucleoid-structuring protein H-NS HVY54_24395 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) HVY54_24410 ENOG4105KK6 nuclease HVY54_24430 ENOG4108EHY type IV secretion system