locus-tag	class	description
HVY54_00010	COG0592	DNA-directed DNA polymerase activity
HVY54_00020	COG0187	DNA topoisomerase II activity
HVY54_00025	COG3753	Protein conserved in bacteria
HVY54_00030	COG0561	phosphatase activity
HVY54_00045	COG0823	Involved in the tonB-independent uptake of proteins
HVY54_00050	COG5645	(Lipo)protein
HVY54_00070	COG2188	Transcriptional regulator
HVY54_00085	COG2207	Transcriptional regulator
HVY54_00090	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HVY54_00095	COG3119	arylsulfatase activity
HVY54_00105	COG2149	membrane
HVY54_00115	COG0641	radical SAM
HVY54_00120	COG2814	Major facilitator Superfamily
HVY54_00135	COG0028	Belongs to the TPP enzyme family
HVY54_00140	COG0440	acetolactate synthase activity
HVY54_00155	COG2197	response regulator
HVY54_00160	COG3851	Histidine kinase
HVY54_00165	COG2271	Major facilitator Superfamily
HVY54_00170	COG2271	Major facilitator Superfamily
HVY54_00185	COG1447	Phosphotransferase system cellobiose-specific component IIA
HVY54_00190	COG2723	6-phospho-beta-galactosidase activity
HVY54_00195	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HVY54_00205	COG1609	Transcriptional regulator
HVY54_00220	COG2252	PERMEase
HVY54_00270	COG0457	Tetratricopeptide repeat
HVY54_00280	COG1464	Belongs to the NlpA lipoprotein family
HVY54_00285	COG0697	spore germination
HVY54_00290	COG2814	Major facilitator Superfamily
HVY54_00345	COG2271	Major facilitator Superfamily
HVY54_00350	COG1609	Transcriptional regulator
HVY54_00360	COG0582	viral genome integration into host DNA
HVY54_00370	COG2211	Major facilitator Superfamily
HVY54_00375	COG1501	Belongs to the glycosyl hydrolase 31 family
HVY54_00385	COG2233	PERMEase
HVY54_00390	COG0786	glutamate:sodium symporter activity
HVY54_00395	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HVY54_00400	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HVY54_00405	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HVY54_00415	COG0194	GDP metabolic process
HVY54_00425	COG2860	membrane
HVY54_00435	COG1561	YicC-like family, N-terminal region
HVY54_00465	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HVY54_00495	COG1519	Transferase
HVY54_00500	COG0859	PFAM glycosyl transferase family 9
HVY54_00505	COG0438	transferase activity, transferring glycosyl groups
HVY54_00510	COG0515	serine threonine protein kinase
HVY54_00525	COG0661	Is probably a protein kinase regulator of UbiI activity which is involved in aerobic coenzyme Q (ubiquinone) biosynthesis
HVY54_00530	COG1442	glycosyl transferase family 8
HVY54_00545	COG0859	PFAM glycosyl transferase family 9
HVY54_00550	COG0859	PFAM glycosyl transferase family 9
HVY54_00560	COG0156	8-amino-7-oxononanoate synthase activity
HVY54_00570	COG1216	Glycosyl transferase, family 2
HVY54_00575	COG2861	carbohydrate metabolic process
HVY54_00580	COG4942	peptidase
HVY54_00590	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HVY54_00595	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HVY54_00610	COG1045	serine acetyltransferase
HVY54_00615	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HVY54_00625	COG2186	Transcriptional regulator
HVY54_00630	COG1620	l-lactate permease
HVY54_00635	COG5295	Hep Hag repeat protein
HVY54_00655	COG3722	fumarate hydratase activity
HVY54_00665	COG2213	PTS system mannitol-specific
HVY54_00665	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HVY54_00675	COG1566	PFAM secretion protein HlyD family protein
HVY54_00720	COG3210	domain, Protein
HVY54_00720	COG3468	outer membrane autotransporter barrel domain protein
HVY54_00725	COG0625	glutathione transferase activity
HVY54_00735	COG3276	selenocysteine insertion sequence binding
HVY54_00740	COG1454	alcohol dehydrogenase
HVY54_00745	COG1012	belongs to the aldehyde dehydrogenase family
HVY54_00760	COG1566	PFAM secretion protein HlyD family protein
HVY54_00765	COG0583	DNA-binding transcription factor activity
HVY54_00770	COG3713	MltA-interacting MipA family protein
HVY54_00780	COG2211	Major facilitator Superfamily
HVY54_00795	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HVY54_00800	COG3977	Valine--pyruvate aminotransferase
HVY54_00805	COG0366	Alpha amylase catalytic
HVY54_00810	COG2992	FlgJ-related protein
HVY54_00815	COG1609	Transcriptional regulator
HVY54_00815	COG2207	Transcriptional regulator
HVY54_00820	COG4214	carbohydrate transport
HVY54_00830	COG4213	ABC transporter substrate-binding protein
HVY54_00840	COG1070	Carbohydrate kinase
HVY54_00845	COG4682	membrane
HVY54_00850	COG4682	membrane
HVY54_00855	COG3274	enterobacterial common antigen metabolic process
HVY54_00880	COG1278	Cold shock
HVY54_00885	COG2944	sequence-specific DNA binding
HVY54_00900	COG2885	chlorophyll binding
HVY54_00905	COG0243	molybdopterin cofactor binding
HVY54_00910	COG0456	acetyltransferase
HVY54_00915	COG2818	Glycosylase
HVY54_00920	COG5571	outer membrane autotransporter
HVY54_00925	COG2223	nitrite transmembrane transporter activity
HVY54_00930	COG3539	Fimbrial protein
HVY54_00935	COG3121	Chaperone
HVY54_00945	COG3539	Fimbrial protein
HVY54_00950	COG3539	Fimbrial protein
HVY54_00955	COG2194	sulfuric ester hydrolase activity
HVY54_00965	COG0747	negative chemotaxis
HVY54_00975	COG0601	transmembrane transport
HVY54_00980	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HVY54_00985	COG0444	Belongs to the ABC transporter superfamily
HVY54_00990	COG4608	Belongs to the ABC transporter superfamily
HVY54_00995	COG0814	amino acid
HVY54_01015	COG2194	sulfuric ester hydrolase activity
HVY54_01040	COG1215	transferase activity, transferring glycosyl groups
HVY54_01045	COG1215	transferase activity, transferring glycosyl groups
HVY54_01050	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
HVY54_01055	COG3118	belongs to the thioredoxin family
HVY54_01055	COG0457	Tetratricopeptide repeat
HVY54_01060	COG2200	EAL domain
HVY54_01060	COG2199	diguanylate cyclase activity
HVY54_01070	COG0612	Peptidase, M16
HVY54_01080	COG2200	EAL domain
HVY54_01085	COG2982	Protein involved in outer membrane biogenesis
HVY54_01090	COG0477	Major facilitator Superfamily
HVY54_01095	COG1295	ribonuclease BN
HVY54_01100	COG0583	DNA-binding transcription factor activity
HVY54_01105	COG2197	response regulator
HVY54_01115	COG1858	cytochrome C peroxidase
HVY54_01120	COG0076	glutamate decarboxylase activity
HVY54_01130	COG2207	Transcriptional regulator
HVY54_01135	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HVY54_01140	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HVY54_01150	COG2771	luxR family
HVY54_01155	COG3247	response to pH
HVY54_01170	COG1285	pathogenesis
HVY54_01180	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HVY54_01190	COG3721	Heme iron utilization protein
HVY54_01200	COG4558	Periplasmic binding protein
HVY54_01205	COG4771	TonB-dependent receptor
HVY54_01210	COG3720	iron ion transport
HVY54_01215	COG2197	response regulator
HVY54_01220	COG3065	identical protein binding
HVY54_01230	COG1393	Belongs to the ArsC family
HVY54_01245	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HVY54_01250	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
HVY54_01255	COG0339	signal peptide processing
HVY54_01265	COG3104	oligopeptide transport
HVY54_01270	COG0589	response to stress
HVY54_01280	COG0306	phosphate transporter
HVY54_01285	COG2081	HI0933 family
HVY54_01305	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HVY54_01310	COG0842	Transport permease protein
HVY54_01310	COG1129	ABC transporter
HVY54_01315	COG0842	Transport permease protein
HVY54_01345	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HVY54_01350	COG0601	transmembrane transport
HVY54_01355	COG0747	negative chemotaxis
HVY54_01360	COG2091	lysine biosynthetic process via aminoadipic acid
HVY54_01365	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HVY54_01370	COG1028	Short-chain dehydrogenase reductase Sdr
HVY54_01380	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HVY54_01405	COG1216	Glycosyl transferase, family 2
HVY54_01425	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HVY54_01435	COG0204	Acyl-transferase
HVY54_01455	COG0628	permease
HVY54_01470	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
HVY54_01485	COG3714	YhhN family
HVY54_01495	COG3776	membrane
HVY54_01500	COG0742	ribosomal rna small subunit methyltransferase
HVY54_01505	COG0552	protein localization to endoplasmic reticulum
HVY54_01510	COG2884	Cell division ATP-binding protein ftsE
HVY54_01515	COG2177	Part of the ABC transporter FtsEX involved in
HVY54_01520	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HVY54_01525	COG0683	leucine binding
HVY54_01530	COG0456	acetyltransferase
HVY54_01535	COG0683	leucine binding
HVY54_01540	COG0559	Belongs to the binding-protein-dependent transport system permease family
HVY54_01545	COG4177	L-phenylalanine transmembrane transporter activity
HVY54_01550	COG0411	ABC transporter
HVY54_01555	COG0410	ABC transporter
HVY54_01565	COG1653	transport
HVY54_01570	COG1175	transmembrane transport
HVY54_01585	COG0584	glycerophosphoryl diester phosphodiesterase
HVY54_01595	COG0405	Gamma-glutamyltransferase
HVY54_01615	COG3157	Type VI secretion system effector, Hcp
HVY54_01620	COG1247	-acetyltransferase
HVY54_01625	COG0673	inositol 2-dehydrogenase activity
HVY54_01630	COG1741	Belongs to the pirin family
HVY54_01635	COG1609	Transcriptional regulator
HVY54_01640	COG3265	gluconokinase activity
HVY54_01645	COG2610	gluconate transmembrane transporter activity
HVY54_01650	COG0514	ATP-dependent DNA helicase (RecQ)
HVY54_01660	COG2095	MarC family integral membrane protein
HVY54_01665	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HVY54_01670	COG0296	Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position
HVY54_01690	COG0058	SHG alpha-glucan phosphorylase activity
HVY54_01695	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HVY54_01710	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HVY54_01725	COG1349	DNA-binding transcription factor activity
HVY54_01730	COG4650	regulator
HVY54_01735	COG1690	Belongs to the RtcB family
HVY54_01760	COG0058	SHG alpha-glucan phosphorylase activity
HVY54_01765	COG1640	4-alpha-glucanotransferase
HVY54_01770	COG2610	gluconate transmembrane transporter activity
HVY54_01780	COG1040	competence protein
HVY54_01800	COG5464	transposase or invertase
HVY54_01810	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
HVY54_01815	COG1918	ferrous iron import across plasma membrane
HVY54_01820	COG2183	response to ionizing radiation
HVY54_01825	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HVY54_01830	COG0745	RESPONSE REGULATOR receiver
HVY54_01835	COG2205	protein histidine kinase activity
HVY54_01845	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
HVY54_01855	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HVY54_01860	COG1011	Hydrolase
HVY54_01870	COG0494	nUDIX hydrolase
HVY54_01875	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
HVY54_01880	COG4972	Pilus assembly protein
HVY54_01885	COG3166	PFAM Fimbrial assembly family protein
HVY54_01900	COG4796	Type ii and iii secretion system protein
HVY54_01915	COG3266	domain, Protein
HVY54_01920	COG0338	D12 class N6 adenine-specific DNA methyltransferase
HVY54_01925	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HVY54_01935	COG0180	Tryptophanyl-tRNA synthetase
HVY54_01940	COG2188	Transcriptional regulator
HVY54_01950	COG3457	Alanine racemase
HVY54_01955	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
HVY54_01960	COG1735	metal-dependent hydrolase with the TIM-barrel fold
HVY54_01975	COG0626	cystathionine gamma-synthase activity
HVY54_01980	COG2188	Transcriptional regulator
HVY54_01990	COG1082	Xylose isomerase domain protein TIM barrel
HVY54_01995	COG2222	sugar isomerase
HVY54_02000	COG0531	amino acid
HVY54_02015	COG2116	formate transmembrane transporter activity
HVY54_02020	COG2146	nitrite reductase [NAD(P)H] activity
HVY54_02025	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HVY54_02035	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HVY54_02045	COG2184	nucleotidyltransferase activity
HVY54_02050	COG0512	Glutamine amidotransferase of anthranilate synthase
HVY54_02055	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HVY54_02060	COG1289	transmembrane transporter activity
HVY54_02065	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HVY54_02070	COG1765	OsmC-like protein
HVY54_02075	COG3954	Phosphoribulokinase
HVY54_02085	COG0429	hydrolase of the alpha beta-hydrolase fold
HVY54_02090	COG0488	(ABC) transporter
HVY54_02105	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
HVY54_02110	COG1047	Peptidyl-prolyl cis-trans
HVY54_02120	COG0545	Peptidyl-prolyl cis-trans isomerase
HVY54_02125	COG2964	Protein conserved in bacteria
HVY54_02195	COG0089	rRNA binding
HVY54_02285	COG0201	protein transport
HVY54_02325	COG0789	Transcriptional regulator
HVY54_02330	COG3036	rescue of stalled ribosome
HVY54_02340	COG0569	domain protein
HVY54_02360	COG0758	DNA mediated transformation
HVY54_02370	COG0551	DNA topoisomerase type I activity
HVY54_02375	COG0009	L-threonylcarbamoyladenylate synthase
HVY54_02390	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HVY54_02430	COG1126	abc transporter atp-binding protein
HVY54_02435	COG0765	amino acid transport
HVY54_02440	COG4597	amino acid ABC transporter
HVY54_02445	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HVY54_02455	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HVY54_02460	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HVY54_02465	COG1309	transcriptional regulator
HVY54_02475	COG2189	Belongs to the N(4) N(6)-methyltransferase family
HVY54_02485	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HVY54_02495	COG4145	pantothenate transmembrane transporter activity
HVY54_02500	COG3924	membrane
HVY54_02505	COG0439	Biotin carboxylase
HVY54_02510	COG0511	ligase activity, forming carbon-carbon bonds
HVY54_02520	COG0604	alcohol dehydrogenase
HVY54_02525	COG2199	diguanylate cyclase activity
HVY54_02525	COG2200	EAL domain
HVY54_02530	COG1077	Cell shape determining protein MreB Mrl
HVY54_02535	COG1792	Involved in formation and maintenance of cell shape
HVY54_02540	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
HVY54_02545	COG0424	maF-like protein
HVY54_02550	COG1530	ribonuclease E activity
HVY54_02555	COG3164	Protein of unknown function
HVY54_02560	COG0312	modulator of DNA gyrase
HVY54_02565	COG0583	DNA-binding transcription factor activity
HVY54_02585	COG2732	(Barnase) inhibitor
HVY54_02605	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HVY54_02610	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HVY54_02615	COG3105	Protein conserved in bacteria
HVY54_02620	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
HVY54_02635	COG0625	glutathione transferase activity
HVY54_02640	COG2969	positive regulation of protein catabolic process
HVY54_02645	COG3069	C4-dicarboxylate transmembrane transporter activity
HVY54_02675	COG2731	YhcH YjgK YiaL family protein
HVY54_02680	COG4804	nuclease activity
HVY54_02685	COG0493	'glutamate synthase
HVY54_02690	COG0070	glutamate synthase
HVY54_02690	COG0067	glutamate synthase
HVY54_02690	COG0069	glutamate synthase activity
HVY54_02695	COG1242	4 iron, 4 sulfur cluster binding
HVY54_02700	COG2198	Histidine kinase
HVY54_02700	COG0784	Response regulator, receiver
HVY54_02700	COG5002	protein histidine kinase activity
HVY54_02705	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
HVY54_02715	COG0515	serine threonine protein kinase
HVY54_02720	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HVY54_02735	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HVY54_02740	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
HVY54_02745	COG1137	ATPase activity
HVY54_02750	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
HVY54_02755	COG3117	lipopolysaccharide transmembrane transporter activity
HVY54_02760	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
HVY54_02765	COG0517	IMP dehydrogenase activity
HVY54_02765	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HVY54_02770	COG0530	calcium, potassium:sodium antiporter activity
HVY54_02775	COG1127	ABC transporter
HVY54_02780	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HVY54_02785	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HVY54_02790	COG2854	intermembrane phospholipid transfer
HVY54_02795	COG3113	response to antibiotic
HVY54_02800	COG5007	Belongs to the BolA IbaG family
HVY54_02810	COG3423	Transcriptional regulator
HVY54_02815	COG0142	geranyltranstransferase activity
HVY54_02830	COG0697	spore germination
HVY54_02840	COG2027	D-alanyl-D-alanine carboxypeptidase
HVY54_02845	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HVY54_02850	COG1534	Rna-binding protein
HVY54_02860	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HVY54_02865	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HVY54_02875	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HVY54_02885	COG2194	sulfuric ester hydrolase activity
HVY54_02905	COG0195	Participates in both transcription termination and antitermination
HVY54_02945	COG0513	Belongs to the DEAD box helicase family
HVY54_02950	COG0814	amino acid
HVY54_02955	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HVY54_02960	COG0826	peptidase U32
HVY54_02965	COG0826	peptidase U32
HVY54_02970	COG3154	lipid carrier protein
HVY54_02975	COG3153	acetyltransferase
HVY54_02990	COG0693	protein deglycase activity
HVY54_02995	COG0702	epimerase
HVY54_03000	COG0701	Predicted permease
HVY54_03005	COG2823	Periplasmic or secreted lipoprotein
HVY54_03020	COG3107	peptidoglycan biosynthetic process
HVY54_03025	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HVY54_03040	COG0363	glucosamine-6-phosphate deaminase activity
HVY54_03045	COG3716	PTS system mannose fructose sorbose family IID component
HVY54_03050	COG3715	PTS system
HVY54_03055	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HVY54_03065	COG2222	sugar isomerase
HVY54_03070	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HVY54_03075	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HVY54_03080	COG3716	PTS system mannose fructose sorbose family IID component
HVY54_03090	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HVY54_03100	COG1349	DNA-binding transcription factor activity
HVY54_03110	COG2002	toxin-antitoxin pair type II binding
HVY54_03115	COG2721	sulfolactate sulfo-lyase activity
HVY54_03120	COG2271	Major facilitator Superfamily
HVY54_03130	COG2084	Dehydrogenase
HVY54_03135	COG1929	Belongs to the glycerate kinase type-1 family
HVY54_03160	COG0583	DNA-binding transcription factor activity
HVY54_03165	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HVY54_03175	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HVY54_03180	COG1882	Formate acetyltransferase
HVY54_03185	COG0251	oxidation-reduction process
HVY54_03190	COG1760	l-serine dehydratase
HVY54_03195	COG0814	amino acid
HVY54_03210	COG1741	Belongs to the pirin family
HVY54_03215	COG0583	DNA-binding transcription factor activity
HVY54_03220	COG3152	Membrane
HVY54_03225	COG3152	Membrane
HVY54_03230	COG0435	Glutathione S-transferase
HVY54_03235	COG2259	Doxx family
HVY54_03245	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
HVY54_03250	COG4575	ribosome binding
HVY54_03255	COG1422	Protein of unknown function (DUF1090)
HVY54_03265	COG0586	Pfam SNARE associated Golgi protein
HVY54_03270	COG2186	Transcriptional regulator
HVY54_03275	COG2271	Major facilitator Superfamily
HVY54_03285	COG2721	sulfolactate sulfo-lyase activity
HVY54_03295	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
HVY54_03300	COG0861	Integral membrane protein TerC family
HVY54_03305	COG0673	inositol 2-dehydrogenase activity
HVY54_03310	COG2949	membrane
HVY54_03315	COG1451	nucleotide metabolic process
HVY54_03325	COG4680	protein conserved in bacteria
HVY54_03330	COG5499	transcription regulator containing HTH domain
HVY54_03335	COG1902	pentaerythritol trinitrate reductase activity
HVY54_03335	COG0446	pyridine nucleotide-disulphide oxidoreductase
HVY54_03340	COG1626	Provides the cells with the ability to utilize trehalose at high osmolarity by splitting it into glucose molecules that can subsequently be taken up by the phosphotransferase-mediated uptake system
HVY54_03340	COG3408	Glycogen debranching enzyme
HVY54_03350	COG0531	amino acid
HVY54_03355	COG2731	YhcH YjgK YiaL family protein
HVY54_03360	COG3250	beta-galactosidase activity
HVY54_03365	COG1609	Transcriptional regulator
HVY54_03370	COG0073	Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation
HVY54_03380	COG0840	transmembrane signaling receptor activity
HVY54_03385	COG1695	Transcriptional regulator
HVY54_03390	COG2375	cellular response to nickel ion
HVY54_03405	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HVY54_03410	COG0358	DNA primase activity
HVY54_03415	COG0828	Belongs to the bacterial ribosomal protein bS21 family
HVY54_03425	COG0471	metal ion transport
HVY54_03430	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HVY54_03435	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
HVY54_03440	COG0583	DNA-binding transcription factor activity
HVY54_03450	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HVY54_03465	COG4991	sh3 domain protein
HVY54_03470	COG3025	triphosphatase activity
HVY54_03495	COG2268	Band 7 protein
HVY54_03500	COG1585	Membrane protein implicated in regulation of membrane protease activity
HVY54_03530	COG3384	dioxygenase
HVY54_03535	COG0754	glutathionylspermidine amidase activity
HVY54_03545	COG1538	Outer membrane efflux protein
HVY54_03550	COG0494	nUDIX hydrolase
HVY54_03555	COG3151	Protein conserved in bacteria
HVY54_03560	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HVY54_03565	COG3150	esterase
HVY54_03570	COG0187	DNA topoisomerase II activity
HVY54_03575	COG4774	siderophore transport
HVY54_03580	COG1120	ATPase activity
HVY54_03585	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HVY54_03590	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HVY54_03600	COG1737	Transcriptional regulator
HVY54_03605	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
HVY54_03610	COG2249	NAD(P)H dehydrogenase (quinone) activity
HVY54_03615	COG0642	Histidine kinase
HVY54_03620	COG0745	RESPONSE REGULATOR receiver
HVY54_03625	COG3111	PFAM Bacterial OB fold (BOF) protein
HVY54_03630	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
HVY54_03635	COG4166	transmembrane transport
HVY54_03640	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HVY54_03645	COG0204	Acyl-transferase
HVY54_03650	COG2132	Multicopper oxidase
HVY54_03655	COG1032	radical SAM domain protein
HVY54_03660	COG4238	major outer membrane lipoprotein
HVY54_03670	COG0656	L-ascorbic acid biosynthetic process
HVY54_03675	COG1979	alcohol dehydrogenase
HVY54_03680	COG2207	Transcriptional regulator
HVY54_03685	COG0586	Pfam SNARE associated Golgi protein
HVY54_03690	COG0626	cystathionine gamma-synthase activity
HVY54_03695	COG0811	peptide transport
HVY54_03700	COG0848	biopolymer transport protein
HVY54_03705	COG1028	Short-chain dehydrogenase reductase Sdr
HVY54_03715	COG0667	Aldo Keto reductase
HVY54_03730	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
HVY54_03735	COG0437	4 iron, 4 sulfur cluster binding
HVY54_03740	COG5557	Pfam Polysulphide reductase, NrfD
HVY54_03745	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
HVY54_03750	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
HVY54_03755	COG1773	rubredoxin
HVY54_03765	COG0298	carbon dioxide binding
HVY54_03770	COG0625	glutathione transferase activity
HVY54_03775	COG0754	glutathionylspermidine amidase activity
HVY54_03780	COG0306	phosphate transporter
HVY54_03785	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HVY54_03790	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HVY54_03795	COG0125	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis
HVY54_03800	COG2244	polysaccharide biosynthetic process
HVY54_03810	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
HVY54_03815	COG0795	lipopolysaccharide-transporting ATPase activity
HVY54_03825	COG0156	8-amino-7-oxononanoate synthase activity
HVY54_03830	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HVY54_03840	COG0318	PFAM AMP-dependent synthetase and ligase
HVY54_03845	COG0456	acetyltransferase
HVY54_03850	COG2186	Transcriptional regulator
HVY54_03855	COG0277	FAD linked oxidase domain protein
HVY54_03860	COG0277	FAD linked oxidase domain protein
HVY54_03865	COG0247	lactate metabolic process
HVY54_03870	COG3193	protein, possibly involved in utilization of glycolate and propanediol
HVY54_03875	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
HVY54_03880	COG1620	l-lactate permease
HVY54_03905	COG4964	Belongs to the GSP D family
HVY54_04015	COG1811	Na channel or pump
HVY54_04020	COG1982	Orn Lys Arg decarboxylase major
HVY54_04025	COG2211	Major facilitator Superfamily
HVY54_04040	COG1194	a g-specific adenine glycosylase
HVY54_04050	COG3171	Protein conserved in bacteria
HVY54_04060	COG0252	asparaginase activity
HVY54_04070	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HVY54_04085	COG0762	integral membrane protein
HVY54_04090	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HVY54_04095	COG2805	Type II/IV secretion system protein
HVY54_04110	COG0189	ligase activity
HVY54_04115	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HVY54_04120	COG2356	endonuclease I
HVY54_04130	COG2814	Major facilitator Superfamily
HVY54_04150	COG1166	arginine decarboxylase activity
HVY54_04165	COG0501	Belongs to the peptidase M48B family
HVY54_04170	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HVY54_04175	COG0330	HflC and HflK could
HVY54_04180	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HVY54_04185	COG2213	PTS system mannitol-specific
HVY54_04190	COG1063	alcohol dehydrogenase
HVY54_04195	COG1494	fructose-1,6-bisphosphatase
HVY54_04205	COG1072	(Pantothenic acid kinase))
HVY54_04210	COG1122	ATPase activity
HVY54_04215	COG1122	ATPase activity
HVY54_04245	COG0191	fructose-bisphosphate aldolase activity
HVY54_04250	COG0668	transmembrane transport
HVY54_04265	COG1279	arginine transmembrane transporter activity
HVY54_04270	COG2968	Membrane
HVY54_04275	COG0583	DNA-binding transcription factor activity
HVY54_04280	COG0427	acetyl-CoA hydrolase
HVY54_04285	COG1024	Enoyl-CoA hydratase
HVY54_04290	COG1703	isobutyryl-CoA mutase activity
HVY54_04295	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HVY54_04295	COG1884	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HVY54_04315	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HVY54_04325	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HVY54_04345	COG0006	proline dipeptidase activity
HVY54_04350	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HVY54_04355	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HVY54_04380	COG2723	6-phospho-beta-galactosidase activity
HVY54_04390	COG1272	protein, Hemolysin III
HVY54_04400	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
HVY54_04410	COG0716	FMN binding
HVY54_04415	COG4974	Belongs to the 'phage' integrase family
HVY54_04420	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HVY54_04425	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HVY54_04435	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HVY54_04455	COG2233	PERMEase
HVY54_04465	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HVY54_04470	COG2252	PERMEase
HVY54_04475	COG0402	S-adenosylhomocysteine deaminase activity
HVY54_04480	COG2233	PERMEase
HVY54_04485	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HVY54_04485	COG2080	2 iron, 2 sulfur cluster binding
HVY54_04490	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
HVY54_04495	COG0402	S-adenosylhomocysteine deaminase activity
HVY54_04500	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HVY54_04500	COG0493	'glutamate synthase
HVY54_04505	COG2068	MobA-Related Protein
HVY54_04510	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HVY54_04515	COG3608	succinylglutamate desuccinylase aspartoacylase
HVY54_04515	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
HVY54_04520	COG0549	Belongs to the carbamate kinase family
HVY54_04530	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HVY54_04535	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HVY54_04540	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HVY54_04550	COG2080	2 iron, 2 sulfur cluster binding
HVY54_04555	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
HVY54_04560	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HVY54_04565	COG4942	peptidase
HVY54_04575	COG3387	PFAM Glycoside hydrolase 15-related
HVY54_04585	COG2207	Transcriptional regulator
HVY54_04690	COG2197	response regulator
HVY54_04695	COG0741	lytic transglycosylase activity
HVY54_04705	COG0457	Tetratricopeptide repeat
HVY54_04705	COG3710	Transcriptional regulator
HVY54_04710	COG0457	Tetratricopeptide repeat
HVY54_04735	COG3710	Transcriptional regulator
HVY54_04740	COG2771	luxR family
HVY54_04745	COG0814	amino acid
HVY54_04750	COG0183	Belongs to the thiolase family
HVY54_04760	COG1028	Short-chain dehydrogenase reductase Sdr
HVY54_04765	COG2814	Major facilitator Superfamily
HVY54_04770	COG1794	racemase activity, acting on amino acids and derivatives
HVY54_04775	COG0583	DNA-binding transcription factor activity
HVY54_04785	COG1609	Transcriptional regulator
HVY54_04800	COG0667	Aldo Keto reductase
HVY54_04810	COG0861	Integral membrane protein TerC family
HVY54_04825	COG3605	phosphoenolpyruvate-protein phosphotransferase activity
HVY54_04840	COG2165	general secretion pathway protein
HVY54_04845	COG4795	General secretion pathway protein
HVY54_04855	COG4967	type IV pilus modification protein PilV
HVY54_04860	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
HVY54_04865	COG1025	Belongs to the peptidase M16 family
HVY54_04870	COG1074	ATP-dependent DNA helicase activity
HVY54_04875	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HVY54_04880	COG0548	Belongs to the acetylglutamate kinase family. ArgB subfamily
HVY54_04880	COG1246	Belongs to the acetyltransferase family. ArgA subfamily
HVY54_04885	COG0860	N-Acetylmuramoyl-L-alanine amidase
HVY54_04905	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
HVY54_04910	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HVY54_04915	COG2166	iron-sulfur cluster assembly
HVY54_04920	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HVY54_04930	COG0583	DNA-binding transcription factor activity
HVY54_04935	COG2363	Small membrane protein
HVY54_04945	COG1349	DNA-binding transcription factor activity
HVY54_04955	COG1070	Carbohydrate kinase
HVY54_04965	COG0738	Major facilitator superfamily
HVY54_04970	COG0235	Class ii aldolase
HVY54_04975	COG1454	alcohol dehydrogenase
HVY54_04985	COG1760	l-serine dehydratase
HVY54_04990	COG0814	amino acid
HVY54_04995	COG1611	Belongs to the LOG family
HVY54_05010	COG3098	single-species biofilm formation
HVY54_05015	COG0564	pseudouridine synthase activity
HVY54_05020	COG0716	FMN binding
HVY54_05025	COG2271	Major facilitator Superfamily
HVY54_05030	COG4948	Mandelate Racemase Muconate Lactonizing
HVY54_05035	COG4948	Mandelate Racemase Muconate Lactonizing
HVY54_05040	COG3850	Histidine kinase
HVY54_05040	COG4999	Histidine kinase
HVY54_05040	COG3437	response regulator, receiver
HVY54_05040	COG2205	protein histidine kinase activity
HVY54_05050	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HVY54_05055	COG2336	PFAM SpoVT AbrB
HVY54_05060	COG2337	Toxic component of a toxin-antitoxin (TA) module
HVY54_05065	COG3956	TIGRFAM MazG family protein
HVY54_05080	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
HVY54_05090	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
HVY54_05100	COG0602	queuosine metabolic process
HVY54_05105	COG1070	Carbohydrate kinase
HVY54_05110	COG2223	nitrite transmembrane transporter activity
HVY54_05115	COG1028	Short-chain dehydrogenase reductase Sdr
HVY54_05120	COG0277	FAD linked oxidase domain protein
HVY54_05125	COG0477	Major facilitator Superfamily
HVY54_05130	COG2086	electron transfer activity
HVY54_05135	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
HVY54_05140	COG1954	Regulates expression of the glpD operon. In the presence of glycerol 3-phosphate (G3P) causes antitermination of transcription of glpD at the inverted repeat of the leader region to enhance its transcription. Binds and stabilizes glpD leader mRNA
HVY54_05145	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
HVY54_05150	COG0644	oxidoreductase
HVY54_05155	COG0720	synthase
HVY54_05190	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HVY54_05195	COG2234	aminopeptidase activity
HVY54_05250	COG1388	LysM domain
HVY54_05250	COG4942	peptidase
HVY54_05255	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HVY54_05265	COG0163	prenyltransferase activity
HVY54_05270	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HVY54_05280	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HVY54_05300	COG3604	Transcriptional regulator
HVY54_05305	COG0309	Hydrogenase expression formation protein (HypE)
HVY54_05310	COG0409	Hydrogenase expression formation protein
HVY54_05315	COG0298	carbon dioxide binding
HVY54_05320	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
HVY54_05325	COG0375	protein maturation
HVY54_05335	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HVY54_05340	COG0651	ATP synthesis coupled electron transport
HVY54_05345	COG0650	Formate hydrogenlyase subunit 4
HVY54_05350	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
HVY54_05350	COG3261	NADH dehydrogenase
HVY54_05355	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HVY54_05360	COG3260	NADH ubiquinone oxidoreductase 20
HVY54_05370	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
HVY54_05380	COG5499	transcription regulator containing HTH domain
HVY54_05385	COG2723	6-phospho-beta-galactosidase activity
HVY54_05390	COG1263	PTS System
HVY54_05390	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HVY54_05395	COG1609	Transcriptional regulator
HVY54_05400	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HVY54_05405	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
HVY54_05425	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HVY54_05425	COG0517	IMP dehydrogenase activity
HVY54_05430	COG1349	DNA-binding transcription factor activity
HVY54_05435	COG4578	phosphoenolpyruvate-dependent sugar phosphotransferase system
HVY54_05440	COG1028	Short-chain dehydrogenase reductase Sdr
HVY54_05455	COG3730	PTS system glucitol sorbitol-specific
HVY54_05460	COG2951	lytic endotransglycosylase activity
HVY54_05465	COG1546	Belongs to the CinA family
HVY54_05485	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
HVY54_05515	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HVY54_05520	COG1238	metal cluster binding
HVY54_05545	COG2814	Major facilitator Superfamily
HVY54_05550	COG1566	PFAM secretion protein HlyD family protein
HVY54_05555	COG1846	Transcriptional regulator
HVY54_05565	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
HVY54_05570	COG2814	Major facilitator Superfamily
HVY54_05575	COG2113	Glycine betaine
HVY54_05580	COG4176	ABC-type proline glycine betaine transport system permease component
HVY54_05585	COG4175	Glycine betaine
HVY54_05590	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HVY54_05595	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HVY54_05605	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HVY54_05610	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HVY54_05620	COG4575	ribosome binding
HVY54_05635	COG2916	Histone family protein nucleoid-structuring protein H-NS
HVY54_05640	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HVY54_05645	COG0640	Transcriptional regulator
HVY54_05650	COG0401	homolog of Blt101
HVY54_05655	COG1652	LysM domain
HVY54_05660	COG1802	Transcriptional regulator
HVY54_05665	COG1113	amino acid transport
HVY54_05670	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HVY54_05675	COG1012	belongs to the aldehyde dehydrogenase family
HVY54_05680	COG0579	oxidoreductase
HVY54_05690	COG0366	Alpha amylase catalytic
HVY54_05715	COG3468	outer membrane autotransporter barrel domain protein
HVY54_05810	COG1475	DNA binding
HVY54_05820	COG0582	viral genome integration into host DNA
HVY54_05835	COG2867	negative regulation of translational initiation
HVY54_05845	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HVY54_05850	COG0497	DNA recombination
HVY54_05865	COG4536	flavin adenine dinucleotide binding
HVY54_05870	COG4137	Cytochrome C assembly protein
HVY54_05875	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HVY54_05900	COG2885	chlorophyll binding
HVY54_05905	COG2199	diguanylate cyclase activity
HVY54_05920	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HVY54_05925	COG1605	Chorismate mutase
HVY54_05925	COG0287	Prephenate dehydrogenase
HVY54_05930	COG1605	Chorismate mutase
HVY54_05930	COG0077	Prephenate dehydratase
HVY54_05940	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HVY54_05945	COG3385	transposase activity
HVY54_05950	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HVY54_05955	COG0564	pseudouridine synthase activity
HVY54_05965	COG0542	response to heat
HVY54_05990	COG0477	Major facilitator Superfamily
HVY54_05995	COG5544	Lipoprotein
HVY54_06000	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HVY54_06005	COG0045	succinate-CoA ligase (ADP-forming) activity
HVY54_06005	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HVY54_06005	COG1042	CoA-binding domain protein
HVY54_06015	COG3118	belongs to the thioredoxin family
HVY54_06020	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HVY54_06040	COG0583	DNA-binding transcription factor activity
HVY54_06045	COG0513	Belongs to the DEAD box helicase family
HVY54_06055	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HVY54_06065	COG1595	DNA-templated transcription, initiation
HVY54_06070	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
HVY54_06075	COG3026	antisigma factor binding
HVY54_06080	COG3086	response to oxidative stress
HVY54_06090	COG0681	Belongs to the peptidase S26 family
HVY54_06110	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
HVY54_06125	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HVY54_06130	COG1737	Transcriptional regulator
HVY54_06135	COG0560	Phosphoserine phosphatase
HVY54_06140	COG0590	tRNA wobble adenosine to inosine editing
HVY54_06150	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HVY54_06150	COG0047	phosphoribosylformylglycinamidine synthase activity
HVY54_06155	COG2205	protein histidine kinase activity
HVY54_06160	COG3170	Tfp pilus assembly protein FimV
HVY54_06165	COG2204	response regulator
HVY54_06170	COG0347	Belongs to the P(II) protein family
HVY54_06175	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HVY54_06175	COG1017	nitric oxide dioxygenase activity
HVY54_06185	COG1940	carbohydrate kinase activity
HVY54_06190	COG0457	Tetratricopeptide repeat
HVY54_06195	COG1879	ABC-type sugar transport system periplasmic component
HVY54_06200	COG1129	ABC transporter
HVY54_06205	COG1172	Belongs to the binding-protein-dependent transport system permease family
HVY54_06210	COG1063	alcohol dehydrogenase
HVY54_06215	COG2017	converts alpha-aldose to the beta-anomer
HVY54_06220	COG2259	Doxx family
HVY54_06245	COG4638	Rieske (2fe-2S)
HVY54_06250	COG0583	DNA-binding transcription factor activity
HVY54_06255	COG2814	Major facilitator Superfamily
HVY54_06260	COG3711	transcriptional antiterminator
HVY54_06265	COG1073	alpha beta
HVY54_06270	COG0483	inositol monophosphate 1-phosphatase activity
HVY54_06290	COG0822	iron-sulfur transferase activity
HVY54_06310	COG0633	Ferredoxin
HVY54_06315	COG2975	iron-sulfur cluster assembly
HVY54_06335	COG2897	thiosulfate sulfurtransferase activity
HVY54_06340	COG2373	Large extracellular alpha-helical protein
HVY54_06345	COG4953	penicillin-binding protein 1C
HVY54_06375	COG2976	Protein conserved in bacteria
HVY54_06390	COG1645	bacterial-type flagellum-dependent swarming motility
HVY54_06410	COG0517	IMP dehydrogenase activity
HVY54_06410	COG0516	GMP reductase activity
HVY54_06450	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HVY54_06525	COG3728	DNA packaging
HVY54_06525	COG5484	DNA packaging
HVY54_06665	COG3179	chitinase
HVY54_06680	COG3133	Outer membrane lipoprotein
HVY54_06695	COG2200	EAL domain
HVY54_06700	COG0248	Ppx GppA phosphatase
HVY54_06705	COG0855	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP)
HVY54_06710	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HVY54_06725	COG2233	PERMEase
HVY54_06735	COG1393	Belongs to the ArsC family
HVY54_06740	COG4783	chaperone-mediated protein folding
HVY54_06745	COG0628	permease
HVY54_06750	COG2116	formate transmembrane transporter activity
HVY54_06755	COG3604	Transcriptional regulator
HVY54_06765	COG3260	NADH ubiquinone oxidoreductase 20
HVY54_06770	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HVY54_06775	COG3261	NADH dehydrogenase
HVY54_06775	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
HVY54_06780	COG0651	ATP synthesis coupled electron transport
HVY54_06785	COG4237	Hydrogenase 4 membrane
HVY54_06790	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HVY54_06795	COG0650	Formate hydrogenlyase subunit 4
HVY54_06800	COG0651	ATP synthesis coupled electron transport
HVY54_06805	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HVY54_06810	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HVY54_06815	COG2716	regulation of RNA biosynthetic process
HVY54_06825	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
HVY54_06835	COG2321	neutral zinc metallopeptidase
HVY54_06845	COG0400	carboxylic ester hydrolase activity
HVY54_06860	COG1393	Belongs to the ArsC family
HVY54_06870	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HVY54_06875	COG3850	Histidine kinase
HVY54_06880	COG0493	'glutamate synthase
HVY54_06880	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HVY54_06890	COG5342	invasion associated locus B
HVY54_06895	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HVY54_06900	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HVY54_06905	COG0280	phosphate acetyltransferase
HVY54_06905	COG0281	malic enzyme
HVY54_06910	COG4810	utilization protein
HVY54_06915	COG4917	ethanolamine utilization protein
HVY54_06920	COG4766	ethanolamine catabolic process
HVY54_06925	COG4812	Cobalamin adenosyltransferase
HVY54_06930	COG0280	phosphate acetyltransferase
HVY54_06935	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
HVY54_06940	COG4576	ethanolamine utilization protein EutN carboxysome structural protein Ccml
HVY54_06945	COG1012	belongs to the aldehyde dehydrogenase family
HVY54_06950	COG4820	ethanolamine utilization protein (EutJ)
HVY54_06955	COG1454	alcohol dehydrogenase
HVY54_06960	COG3192	ethanolamine utilization protein
HVY54_06965	COG4819	ethanolamine utilization protein
HVY54_06970	COG4303	Ethanolamine ammonia lyase large subunit
HVY54_06980	COG4816	utilization protein
HVY54_06985	COG4577	Carbon dioxide concentrating mechanism carboxysome shell protein
HVY54_06990	COG2207	Transcriptional regulator
HVY54_07000	COG0860	N-Acetylmuramoyl-L-alanine amidase
HVY54_07020	COG2837	iron assimilation
HVY54_07025	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HVY54_07030	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HVY54_07030	COG1263	PTS System
HVY54_07045	COG1028	Short-chain dehydrogenase reductase Sdr
HVY54_07050	COG4150	thiosulfate binding
HVY54_07055	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
HVY54_07060	COG4208	sulfate ABC transporter
HVY54_07065	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
HVY54_07070	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HVY54_07085	COG3385	transposase activity
HVY54_07090	COG2190	(PTS) system
HVY54_07095	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HVY54_07100	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HVY54_07105	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HVY54_07125	COG3530	Putative quorum-sensing-regulated virulence factor
HVY54_07130	COG0385	Bile acid
HVY54_07135	COG0583	DNA-binding transcription factor activity
HVY54_07170	COG3415	Transposase
HVY54_07175	COG3415	Transposase
HVY54_07190	COG2199	diguanylate cyclase activity
HVY54_07190	COG2200	EAL domain
HVY54_07195	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HVY54_07220	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HVY54_07225	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HVY54_07230	COG0006	proline dipeptidase activity
HVY54_07235	COG1363	Peptidase, m42
HVY54_07240	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HVY54_07240	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HVY54_07240	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HVY54_07245	COG2207	Transcriptional regulator
HVY54_07250	COG3279	Response regulator of the LytR AlgR family
HVY54_07255	COG3275	phosphorelay sensor kinase activity
HVY54_07260	COG0436	Aminotransferase
HVY54_07270	COG1560	Kdo2-lipid A biosynthetic process
HVY54_07295	COG0028	Belongs to the TPP enzyme family
HVY54_07300	COG0679	Auxin Efflux Carrier
HVY54_07305	COG1804	L-carnitine dehydratase bile acid-inducible protein F
HVY54_07310	COG0784	Response regulator, receiver
HVY54_07310	COG2198	Histidine kinase
HVY54_07310	COG2205	protein histidine kinase activity
HVY54_07310	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HVY54_07315	COG2197	response regulator
HVY54_07320	COG1566	PFAM secretion protein HlyD family protein
HVY54_07325	COG0477	Major facilitator Superfamily
HVY54_07370	COG2116	formate transmembrane transporter activity
HVY54_07375	COG2853	Lipoprotein
HVY54_07385	COG2067	long-chain fatty acid transport protein
HVY54_07390	COG3691	Protein conserved in bacteria
HVY54_07405	COG2062	phosphohistidine phosphatase, SixA
HVY54_07410	COG3539	Fimbrial protein
HVY54_07415	COG3188	usher protein
HVY54_07420	COG3121	Chaperone
HVY54_07425	COG3539	Fimbrial protein
HVY54_07430	COG3539	Fimbrial protein
HVY54_07435	COG3539	Fimbrial protein
HVY54_07450	COG2890	protein-(glutamine-N5) methyltransferase activity
HVY54_07465	COG0730	response to heat
HVY54_07470	COG3101	peptidyl-lysine hydroxylation
HVY54_07485	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HVY54_07490	COG2814	Major facilitator Superfamily
HVY54_07500	COG2314	TM2 domain
HVY54_07555	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HVY54_07590	COG4695	Portal protein
HVY54_07675	COG4974	Belongs to the 'phage' integrase family
HVY54_07685	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HVY54_07695	COG0586	Pfam SNARE associated Golgi protein
HVY54_07705	COG0285	dihydrofolate synthase activity
HVY54_07710	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
HVY54_07715	COG1286	toxin biosynthetic process
HVY54_07720	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HVY54_07725	COG0163	prenyltransferase activity
HVY54_07730	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HVY54_07735	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HVY54_07740	COG4215	(ABC) transporter
HVY54_07745	COG4160	amino acid transport
HVY54_07750	COG4598	ABC transporter
HVY54_07755	COG5464	transposase or invertase
HVY54_07760	COG1090	epimerase
HVY54_07765	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HVY54_07770	COG0625	glutathione transferase activity
HVY54_07775	COG0625	glutathione transferase activity
HVY54_07780	COG0622	Phosphoesterase
HVY54_07785	COG1443	Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP)
HVY54_07790	COG1288	antiporter activity
HVY54_07795	COG0280	phosphate acetyltransferase
HVY54_07795	COG0857	belongs to the CobB CobQ family
HVY54_07800	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HVY54_07815	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HVY54_07820	COG0471	metal ion transport
HVY54_07820	COG0490	domain, Protein
HVY54_07830	COG0436	Aminotransferase
HVY54_07835	COG0583	DNA-binding transcription factor activity
HVY54_07855	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
HVY54_07860	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
HVY54_07865	COG1034	ATP synthesis coupled electron transport
HVY54_07880	COG0839	Belongs to the complex I subunit 6 family
HVY54_07890	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HVY54_07895	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HVY54_07925	COG2153	protein acetylation
HVY54_07930	COG4575	ribosome binding
HVY54_07935	COG1169	isochorismate synthase
HVY54_07950	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
HVY54_07960	COG0318	PFAM AMP-dependent synthetase and ligase
HVY54_08025	COG1414	Transcriptional regulator
HVY54_08035	COG2271	Major facilitator Superfamily
HVY54_08040	COG3836	Belongs to the HpcH HpaI aldolase family
HVY54_08050	COG5464	transposase or invertase
HVY54_08055	COG0247	lactate metabolic process
HVY54_08065	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HVY54_08070	COG2271	Major facilitator Superfamily
HVY54_08075	COG0584	glycerophosphoryl diester phosphodiesterase
HVY54_08080	COG0583	DNA-binding transcription factor activity
HVY54_08085	COG2814	Major facilitator Superfamily
HVY54_08090	COG3642	lipopolysaccharide core region biosynthetic process
HVY54_08095	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HVY54_08100	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HVY54_08105	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HVY54_08110	COG3468	outer membrane autotransporter barrel domain protein
HVY54_08120	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HVY54_08125	COG4685	Uncharacterized protein conserved in bacteria (DUF2138)
HVY54_08130	COG3234	Protein of unknown function (DUF1175)
HVY54_08135	COG2373	Large extracellular alpha-helical protein
HVY54_08140	COG5445	Predicted secreted protein (DUF2300)
HVY54_08145	COG4676	Protein conserved in bacteria
HVY54_08150	COG0183	Belongs to the thiolase family
HVY54_08155	COG2031	fatty acid transporter
HVY54_08160	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HVY54_08165	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HVY54_08170	COG2204	response regulator
HVY54_08175	COG3852	Histidine kinase
HVY54_08180	COG0784	Response regulator, receiver
HVY54_08180	COG2205	protein histidine kinase activity
HVY54_08185	COG2197	response regulator
HVY54_08190	COG2198	Histidine kinase
HVY54_08190	COG0642	Histidine kinase
HVY54_08195	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HVY54_08200	COG1477	protein flavinylation
HVY54_08205	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HVY54_08205	COG2169	Transcriptional regulator
HVY54_08210	COG3145	DNA-N1-methyladenine dioxygenase activity
HVY54_08215	COG4615	Cyclic peptide transporter
HVY54_08235	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HVY54_08235	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
HVY54_08240	COG3062	negative regulation of establishment of protein localization
HVY54_08250	COG0437	4 iron, 4 sulfur cluster binding
HVY54_08255	COG0348	domain, Protein
HVY54_08260	COG3043	anaerobic respiration
HVY54_08265	COG3005	denitrification pathway
HVY54_08270	COG4133	protoheme IX ABC transporter activity
HVY54_08275	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HVY54_08280	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HVY54_08285	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HVY54_08295	COG1138	Cytochrome C-type biogenesis protein
HVY54_08300	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HVY54_08305	COG4235	cytochrome complex assembly
HVY54_08305	COG3088	subunit of a heme lyase
HVY54_08310	COG2197	response regulator
HVY54_08315	COG3468	outer membrane autotransporter barrel domain protein
HVY54_08325	COG3083	sulfuric ester hydrolase activity
HVY54_08345	COG1061	Type III restriction enzyme res subunit
HVY54_08350	COG1187	pseudouridine synthase activity
HVY54_08355	COG2814	Major facilitator Superfamily
HVY54_08365	COG4172	Belongs to the ABC transporter superfamily
HVY54_08370	COG4239	(ABC) transporter, permease
HVY54_08375	COG4174	ABC transporter (Permease)
HVY54_08380	COG4166	transmembrane transport
HVY54_08385	COG2200	EAL domain
HVY54_08390	COG0791	NLP P60 protein
HVY54_08395	COG0671	phosphoesterase, PA-phosphatase related
HVY54_08400	COG0523	cobalamin synthesis protein
HVY54_08405	COG0246	Mannitol dehydrogenase
HVY54_08420	COG2814	Major facilitator Superfamily
HVY54_08425	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HVY54_08425	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HVY54_08430	COG1105	Belongs to the carbohydrate kinase PfkB family
HVY54_08435	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HVY54_08435	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HVY54_08435	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
HVY54_08440	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HVY54_08445	COG2313	pseudouridylate synthase activity
HVY54_08450	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HVY54_08455	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HVY54_08465	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HVY54_08470	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HVY54_08470	COG1522	sequence-specific DNA binding
HVY54_08480	COG2855	membrane
HVY54_08485	COG0583	DNA-binding transcription factor activity
HVY54_08490	COG0833	amino acid
HVY54_08495	COG4771	TonB-dependent receptor
HVY54_08510	COG2311	Membrane
HVY54_08515	COG1609	Transcriptional regulator
HVY54_08520	COG1879	ABC-type sugar transport system periplasmic component
HVY54_08525	COG1129	ABC transporter
HVY54_08530	COG4211	Belongs to the binding-protein-dependent transport system permease family
HVY54_08535	COG0167	dihydroorotate dehydrogenase activity
HVY54_08535	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
HVY54_08540	COG0493	'glutamate synthase
HVY54_08550	COG2949	membrane
HVY54_08560	COG1346	cytolysis
HVY54_08575	COG2271	Major facilitator Superfamily
HVY54_08590	COG0625	glutathione transferase activity
HVY54_08595	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HVY54_08600	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HVY54_08615	COG1028	Short-chain dehydrogenase reductase Sdr
HVY54_08620	COG0586	Pfam SNARE associated Golgi protein
HVY54_08630	COG1686	Belongs to the peptidase S11 family
HVY54_08635	COG0277	FAD linked oxidase domain protein
HVY54_08640	COG1472	Belongs to the glycosyl hydrolase 3 family
HVY54_08645	COG1732	Glycine betaine
HVY54_08650	COG1174	glycine betaine transport
HVY54_08655	COG1125	glycine betaine transport
HVY54_08660	COG1174	glycine betaine transport
HVY54_08670	COG0789	Transcriptional regulator
HVY54_08675	COG3275	phosphorelay sensor kinase activity
HVY54_08680	COG3279	Response regulator of the LytR AlgR family
HVY54_08685	COG4807	Protein conserved in bacteria
HVY54_08690	COG4808	Protein conserved in bacteria
HVY54_08695	COG4715	Zinc finger, swim domain protein
HVY54_08700	COG3552	Protein containing von Willebrand factor type A (VWA) domain
HVY54_08705	COG2425	protein containing a von Willebrand factor type A (vWA) domain
HVY54_08710	COG0714	Associated with various cellular activities
HVY54_08730	COG3831	ATPase activity
HVY54_08740	COG0489	protein tyrosine kinase activity
HVY54_08750	COG3539	Fimbrial protein
HVY54_08755	COG3121	Chaperone
HVY54_08765	COG3539	Fimbrial protein
HVY54_08770	COG5455	response to cobalt ion
HVY54_08790	COG0351	phosphomethylpyrimidine kinase
HVY54_08795	COG3757	hydrolase, family 25
HVY54_08800	COG2188	Transcriptional regulator
HVY54_08805	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HVY54_08810	COG1397	ADP-ribosylglycohydrolase
HVY54_08815	COG2211	Major facilitator Superfamily
HVY54_08820	COG1830	Aldolase
HVY54_08835	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HVY54_08840	COG3414	Phosphotransferase system galactitol-specific IIB component
HVY54_08845	COG3775	system Galactitol-specific IIC component
HVY54_08850	COG1063	alcohol dehydrogenase
HVY54_08880	COG0745	RESPONSE REGULATOR receiver
HVY54_08885	COG2205	protein histidine kinase activity
HVY54_08925	COG4245	von Willebrand factor, type A
HVY54_08930	COG0631	protein serine/threonine phosphatase activity
HVY54_08935	COG4248	protein with protein kinase and helix-hairpin-helix DNA-binding domains
HVY54_08940	COG0443	Heat shock 70 kDa protein
HVY54_08945	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
HVY54_08950	COG5001	Diguanylate cyclase
HVY54_08950	COG3447	MASE1 domain protein
HVY54_08950	COG5002	protein histidine kinase activity
HVY54_08955	COG0572	uridine kinase
HVY54_08965	COG2982	Protein involved in outer membrane biogenesis
HVY54_08970	COG1253	flavin adenine dinucleotide binding
HVY54_08975	COG1596	polysaccharide export
HVY54_08980	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HVY54_08985	COG0489	protein tyrosine kinase activity
HVY54_08985	COG3206	protein involved in exopolysaccharide biosynthesis
HVY54_08990	COG0463	Glycosyl transferase, family 2
HVY54_08995	COG1045	serine acetyltransferase
HVY54_09000	COG0438	transferase activity, transferring glycosyl groups
HVY54_09010	COG1216	Glycosyl transferase, family 2
HVY54_09015	COG0110	maltose O-acetyltransferase activity
HVY54_09020	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
HVY54_09025	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HVY54_09030	COG1051	belongs to the nudix hydrolase family
HVY54_09035	COG0297	glycogen (starch) synthase activity
HVY54_09040	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
HVY54_09040	COG0662	Cupin 2, conserved barrel domain protein
HVY54_09045	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HVY54_09050	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HVY54_09055	COG2244	polysaccharide biosynthetic process
HVY54_09060	COG2327	Polysaccharide pyruvyl transferase
HVY54_09065	COG0438	transferase activity, transferring glycosyl groups
HVY54_09075	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HVY54_09080	COG1088	dTDP-glucose 4,6-dehydratase activity
HVY54_09085	COG1091	dTDP-4-dehydrorhamnose reductase activity
HVY54_09090	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
HVY54_09115	COG0463	Glycosyl transferase, family 2
HVY54_09115	COG1216	Glycosyl transferase, family 2
HVY54_09125	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
HVY54_09130	COG1004	Belongs to the UDP-glucose GDP-mannose dehydrogenase family
HVY54_09155	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HVY54_09160	COG0131	Imidazoleglycerol-phosphate dehydratase
HVY54_09160	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HVY54_09170	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HVY54_09185	COG2161	toxin-antitoxin pair type II binding
HVY54_09190	COG4115	mRNA cleavage
HVY54_09195	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HVY54_09200	COG0583	DNA-binding transcription factor activity
HVY54_09210	COG0531	amino acid
HVY54_09215	COG2391	methyltransferase activity
HVY54_09220	COG0425	Belongs to the sulfur carrier protein TusA family
HVY54_09225	COG2925	Exonuclease
HVY54_09230	COG1686	Belongs to the peptidase S11 family
HVY54_09240	COG1289	transmembrane transporter activity
HVY54_09285	COG2003	Belongs to the UPF0758 family
HVY54_09330	COG1735	metal-dependent hydrolase with the TIM-barrel fold
HVY54_09360	COG2087	Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate
HVY54_09375	COG1376	ErfK ybiS ycfS ynhG family protein
HVY54_09385	COG0583	DNA-binding transcription factor activity
HVY54_09390	COG0583	DNA-binding transcription factor activity
HVY54_09400	COG0534	Mate efflux family protein
HVY54_09410	COG0217	transcriptional regulatory protein
HVY54_09415	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HVY54_09420	COG0477	Major facilitator Superfamily
HVY54_09430	COG1388	LysM domain
HVY54_09430	COG4932	domain protein
HVY54_09430	COG2373	Large extracellular alpha-helical protein
HVY54_09450	COG3038	cytochrome b561
HVY54_09455	COG3443	Belongs to the bacterial solute-binding protein 9 family
HVY54_09470	COG2351	hydroxyisourate hydrolase activity
HVY54_09475	COG0745	RESPONSE REGULATOR receiver
HVY54_09480	COG2205	protein histidine kinase activity
HVY54_09490	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HVY54_09500	COG1418	mRNA catabolic process
HVY54_09505	COG0270	DNA (cytosine-5-)-methyltransferase activity
HVY54_09510	COG3727	T/G mismatch-specific endonuclease activity
HVY54_09515	COG0697	spore germination
HVY54_09520	COG2354	Protein conserved in bacteria
HVY54_09525	COG5475	Uncharacterized small protein (DUF2158)
HVY54_09530	COG3706	GGDEF domain
HVY54_09550	COG2197	response regulator
HVY54_09555	COG1684	flagellar biosynthetic protein fliR
HVY54_09560	COG1987	bacterial-type flagellum assembly
HVY54_09565	COG1338	Plays a role in the flagellum-specific transport system
HVY54_09570	COG3190	flagellar
HVY54_09575	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HVY54_09580	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HVY54_09585	COG1580	Controls the rotational direction of flagella during chemotaxis
HVY54_09590	COG3144	bacterial-type flagellum assembly
HVY54_09595	COG2882	bacterial-type flagellum organization
HVY54_09600	COG1157	protein secretion by the type III secretion system
HVY54_09605	COG1317	bacterial-type flagellum organization
HVY54_09610	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HVY54_09615	COG1766	The M ring may be actively involved in energy transduction
HVY54_09630	COG2135	peptidase activity
HVY54_09635	COG0425	Belongs to the sulfur carrier protein TusA family
HVY54_09640	COG2391	methyltransferase activity
HVY54_09650	COG0366	Alpha amylase catalytic
HVY54_09660	COG1516	flagellar protein fliS
HVY54_09665	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
HVY54_09670	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HVY54_09675	COG1191	sigma factor activity
HVY54_09705	COG2197	response regulator
HVY54_09720	COG2197	response regulator
HVY54_09750	COG3012	SEC-C Motif Domain Protein
HVY54_09750	COG3318	Belongs to the UPF0149 family
HVY54_09755	COG0814	amino acid
HVY54_09765	COG1528	Iron-storage protein
HVY54_09785	COG1528	Iron-storage protein
HVY54_09790	COG1879	ABC-type sugar transport system periplasmic component
HVY54_09795	COG1129	ABC transporter
HVY54_09800	COG1172	Belongs to the binding-protein-dependent transport system permease family
HVY54_09805	COG1877	trehalose-phosphatase activity
HVY54_09815	COG0589	response to stress
HVY54_09830	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
HVY54_09835	COG1360	Flagellar Motor Protein
HVY54_09840	COG0643	Histidine kinase
HVY54_09840	COG2198	Histidine kinase
HVY54_09845	COG0835	chemotaxis
HVY54_09850	COG0840	transmembrane signaling receptor activity
HVY54_09855	COG0840	transmembrane signaling receptor activity
HVY54_09860	COG1352	Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP
HVY54_09870	COG0745	RESPONSE REGULATOR receiver
HVY54_09875	COG3143	Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P)
HVY54_09880	COG1377	Required for formation of the rod structure in the basal body of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HVY54_09885	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HVY54_09895	COG3755	Protein conserved in bacteria
HVY54_09905	COG3102	Protein conserved in bacteria
HVY54_09915	COG3005	denitrification pathway
HVY54_09920	COG0243	molybdopterin cofactor binding
HVY54_09935	COG3788	relative of glutathione S-transferase, MAPEG superfamily
HVY54_09940	COG1801	Protein of unknown function DUF72
HVY54_09945	COG1335	isochorismatase
HVY54_09955	COG0494	nUDIX hydrolase
HVY54_09960	COG0217	transcriptional regulatory protein
HVY54_09990	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HVY54_10000	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
HVY54_10005	COG0739	heme binding
HVY54_10010	COG1560	Kdo2-lipid A biosynthetic process
HVY54_10015	COG0469	pyruvate kinase activity
HVY54_10020	COG1737	Transcriptional regulator
HVY54_10025	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HVY54_10030	COG0129	dihydroxy-acid dehydratase activity
HVY54_10035	COG0800	Aldolase
HVY54_10045	COG3141	response to X-ray
HVY54_10055	COG2979	Protein of unknown function (DUF533)
HVY54_10060	COG1770	oligopeptidase
HVY54_10065	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HVY54_10070	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HVY54_10080	COG2372	response to copper ion
HVY54_10085	COG1276	copper resistance
HVY54_10095	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HVY54_10115	COG3008	intermembrane lipid transfer
HVY54_10120	COG2995	paraquat-inducible protein a
HVY54_10125	COG1956	GAF domain-containing protein
HVY54_10135	COG0793	Belongs to the peptidase S41A family
HVY54_10145	COG2814	Major facilitator Superfamily
HVY54_10150	COG1414	Transcriptional regulator
HVY54_10180	COG2226	methyltransferase
HVY54_10195	COG3716	PTS system mannose fructose sorbose family IID component
HVY54_10200	COG3715	PTS system
HVY54_10205	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HVY54_10205	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HVY54_10210	COG1253	flavin adenine dinucleotide binding
HVY54_10215	COG2200	EAL domain
HVY54_10220	COG1760	l-serine dehydratase
HVY54_10230	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HVY54_10245	COG0251	oxidation-reduction process
HVY54_10250	COG1199	ATP-dependent helicase activity
HVY54_10255	COG1214	PFAM Peptidase M22, glycoprotease
HVY54_10260	COG3065	identical protein binding
HVY54_10265	COG0318	PFAM AMP-dependent synthetase and ligase
HVY54_10270	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
HVY54_10275	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HVY54_10280	COG4638	Rieske (2fe-2S)
HVY54_10285	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HVY54_10295	COG0583	DNA-binding transcription factor activity
HVY54_10305	COG3615	Tellurite resistance protein tehB
HVY54_10315	COG2261	transglycosylase associated protein
HVY54_10330	COG2199	diguanylate cyclase activity
HVY54_10330	COG2203	Gaf domain
HVY54_10335	COG3042	response to heat
HVY54_10340	COG3189	MarR family transcriptional regulator
HVY54_10345	COG2807	transmembrane transport
HVY54_10350	COG2207	Transcriptional regulator
HVY54_10365	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HVY54_10370	COG2199	diguanylate cyclase activity
HVY54_10375	COG2199	diguanylate cyclase activity
HVY54_10385	COG2766	serine protein kinase
HVY54_10390	COG3713	MltA-interacting MipA family protein
HVY54_10395	COG0656	L-ascorbic acid biosynthetic process
HVY54_10400	COG0676	glucose-6-phosphate 1-epimerase activity
HVY54_10405	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HVY54_10415	COG3139	Protein of unknown function (DUF1315)
HVY54_10420	COG1063	alcohol dehydrogenase
HVY54_10425	COG2271	Major facilitator Superfamily
HVY54_10430	COG1063	alcohol dehydrogenase
HVY54_10435	COG0191	fructose-bisphosphate aldolase activity
HVY54_10440	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HVY54_10445	COG0667	Aldo Keto reductase
HVY54_10450	COG1349	DNA-binding transcription factor activity
HVY54_10455	COG2814	Major facilitator Superfamily
HVY54_10460	COG1335	isochorismatase
HVY54_10465	COG0252	asparaginase activity
HVY54_10470	COG0616	signal peptide processing
HVY54_10475	COG0778	Nitroreductase
HVY54_10480	COG0709	Synthesizes selenophosphate from selenide and ATP
HVY54_10485	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HVY54_10495	COG0334	Belongs to the Glu Leu Phe Val dehydrogenases family
HVY54_10505	COG0494	nUDIX hydrolase
HVY54_10510	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HVY54_10515	COG2897	thiosulfate sulfurtransferase activity
HVY54_10520	COG4136	ATPase activity
HVY54_10525	COG4135	transport system, permease component
HVY54_10530	COG4134	Bacterial extracellular solute-binding protein
HVY54_10535	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HVY54_10540	COG0398	Pfam SNARE associated Golgi protein
HVY54_10550	COG0398	Pfam SNARE associated Golgi protein
HVY54_10555	COG0708	Exodeoxyribonuclease III
HVY54_10585	COG3678	ATP-independent chaperone mediated protein folding
HVY54_10595	COG0322	excinuclease ABC activity
HVY54_10605	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HVY54_10610	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HVY54_10615	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HVY54_10620	COG1447	Phosphotransferase system cellobiose-specific component IIA
HVY54_10625	COG1917	Cupin 2, conserved barrel domain protein
HVY54_10625	COG2169	Transcriptional regulator
HVY54_10630	COG1486	melibiose metabolic process
HVY54_10640	COG0753	catalase activity
HVY54_10660	COG1988	membrane-bound metal-dependent
HVY54_10665	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HVY54_10675	COG3001	Fructosamine kinase
HVY54_10685	COG1105	Belongs to the carbohydrate kinase PfkB family
HVY54_10690	COG3137	Salt-induced outer membrane protein
HVY54_10830	COG4974	Belongs to the 'phage' integrase family
HVY54_10850	COG0386	Belongs to the glutathione peroxidase family
HVY54_10860	COG0791	NLP P60 protein
HVY54_10865	COG2200	EAL domain
HVY54_10875	COG4256	Hemin uptake protein
HVY54_10880	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HVY54_10890	COG0574	Belongs to the PEP-utilizing enzyme family
HVY54_10890	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HVY54_10895	COG0318	PFAM AMP-dependent synthetase and ligase
HVY54_10900	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
HVY54_10905	COG0644	oxidoreductase
HVY54_10910	COG2025	fatty acid beta-oxidation using acyl-CoA dehydrogenase
HVY54_10915	COG2086	electron transfer activity
HVY54_10925	COG1960	acyl-CoA dehydrogenase activity
HVY54_10930	COG4670	ketone body catabolic process
HVY54_10945	COG2271	Major facilitator Superfamily
HVY54_10950	COG0738	Major facilitator superfamily
HVY54_10965	COG0628	permease
HVY54_10970	COG0277	FAD linked oxidase domain protein
HVY54_10970	COG0247	lactate metabolic process
HVY54_10975	COG2050	protein possibly involved in aromatic compounds catabolism
HVY54_10985	COG0316	Belongs to the HesB IscA family
HVY54_10990	COG0719	Fe-S assembly protein
HVY54_10995	COG0396	ATPase activity
HVY54_11000	COG0719	Fe-S assembly protein
HVY54_11015	COG1376	ErfK ybiS ycfS ynhG family protein
HVY54_11020	COG4238	major outer membrane lipoprotein
HVY54_11025	COG0469	pyruvate kinase activity
HVY54_11035	COG0437	4 iron, 4 sulfur cluster binding
HVY54_11040	COG2414	aldehyde ferredoxin oxidoreductase
HVY54_11050	COG0437	4 iron, 4 sulfur cluster binding
HVY54_11055	COG4117	Thiosulfate reductase cytochrome B subunit (Membrane anchoring protein)
HVY54_11065	COG4529	Protein conserved in bacteria
HVY54_11085	COG3468	outer membrane autotransporter barrel domain protein
HVY54_11095	COG0307	riboflavin synthase, alpha
HVY54_11100	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HVY54_11105	COG2814	Major facilitator Superfamily
HVY54_11110	COG0583	DNA-binding transcription factor activity
HVY54_11125	COG2814	Major facilitator Superfamily
HVY54_11130	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HVY54_11135	COG0791	NLP P60 protein
HVY54_11140	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
HVY54_11145	COG1201	RNA secondary structure unwinding
HVY54_11155	COG0346	lactoylglutathione lyase activity
HVY54_11160	COG1902	pentaerythritol trinitrate reductase activity
HVY54_11165	COG1309	transcriptional regulator
HVY54_11170	COG3313	Fe-S protein
HVY54_11175	COG4989	oxidoreductase activity
HVY54_11180	COG2032	superoxide dismutase activity
HVY54_11185	COG1289	transmembrane transporter activity
HVY54_11190	COG1566	PFAM secretion protein HlyD family protein
HVY54_11205	COG3133	Outer membrane lipoprotein
HVY54_11215	COG3895	Periplasmic Protein
HVY54_11230	COG2240	Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP
HVY54_11235	COG0625	glutathione transferase activity
HVY54_11240	COG3104	oligopeptide transport
HVY54_11245	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HVY54_11255	COG4659	FMN binding
HVY54_11295	COG0673	inositol 2-dehydrogenase activity
HVY54_11305	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HVY54_11310	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HVY54_11310	COG1263	PTS System
HVY54_11315	COG1609	Transcriptional regulator
HVY54_11320	COG1028	Short-chain dehydrogenase reductase Sdr
HVY54_11325	COG1309	transcriptional regulator
HVY54_11330	COG3250	beta-galactosidase activity
HVY54_11345	COG5339	Protein conserved in bacteria
HVY54_11350	COG1482	cell wall glycoprotein biosynthetic process
HVY54_11355	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HVY54_11355	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
HVY54_11360	COG0114	fumarate hydratase activity
HVY54_11370	COG2205	protein histidine kinase activity
HVY54_11380	COG0745	RESPONSE REGULATOR receiver
HVY54_11385	COG3136	membrane protein required for alginate biosynthesis
HVY54_11395	COG0531	amino acid
HVY54_11405	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
HVY54_11410	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
HVY54_11415	COG0628	permease
HVY54_11430	COG3591	Belongs to the peptidase S1B family
HVY54_11445	COG2814	Major facilitator Superfamily
HVY54_11450	COG0583	DNA-binding transcription factor activity
HVY54_11455	COG1940	carbohydrate kinase activity
HVY54_11460	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HVY54_11470	COG3381	protein complex oligomerization
HVY54_11475	COG3302	dmso reductase anchor subunit
HVY54_11480	COG0437	4 iron, 4 sulfur cluster binding
HVY54_11485	COG0243	molybdopterin cofactor binding
HVY54_11490	COG0243	molybdopterin cofactor binding
HVY54_11505	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HVY54_11520	COG4948	Mandelate Racemase Muconate Lactonizing
HVY54_11525	COG1063	alcohol dehydrogenase
HVY54_11565	COG3077	Addiction module antitoxin, RelB DinJ family
HVY54_11570	COG2026	Addiction module toxin, RelE StbE family
HVY54_11590	COG1403	HNH endonuclease
HVY54_11595	COG0484	heat shock protein binding
HVY54_11605	COG1278	Cold shock
HVY54_11610	COG1278	Cold shock
HVY54_11625	COG3772	lysozyme
HVY54_11635	COG1278	Cold shock
HVY54_11660	COG5562	phage envelope protein
HVY54_11675	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
HVY54_11680	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HVY54_11700	COG0246	Mannitol dehydrogenase
HVY54_11710	COG1802	Transcriptional regulator
HVY54_11715	COG4221	oxidoreductase activity
HVY54_11720	COG0339	signal peptide processing
HVY54_11725	COG1546	Belongs to the CinA family
HVY54_11730	COG3111	PFAM Bacterial OB fold (BOF) protein
HVY54_11735	COG3706	GGDEF domain
HVY54_11745	COG2814	Major facilitator Superfamily
HVY54_11750	COG0697	spore germination
HVY54_11760	COG4977	sequence-specific DNA binding
HVY54_11765	COG1846	Transcriptional regulator
HVY54_11785	COG0583	DNA-binding transcription factor activity
HVY54_11790	COG1012	belongs to the aldehyde dehydrogenase family
HVY54_11795	COG2066	Belongs to the glutaminase family
HVY54_11815	COG3781	membrane
HVY54_11865	COG3210	domain, Protein
HVY54_11865	COG2911	Protein conserved in bacteria
HVY54_11870	COG1396	sequence-specific DNA binding
HVY54_11875	COG3550	peptidyl-serine autophosphorylation
HVY54_12005	COG3539	Fimbrial protein
HVY54_12015	COG3188	usher protein
HVY54_12020	COG3539	Fimbrial protein
HVY54_12025	COG3539	Fimbrial protein
HVY54_12030	COG3539	Fimbrial protein
HVY54_12035	COG0243	molybdopterin cofactor binding
HVY54_12050	COG3119	arylsulfatase activity
HVY54_12055	COG0641	radical SAM
HVY54_12065	COG4178	(ABC) transporter
HVY54_12070	COG4771	TonB-dependent receptor
HVY54_12075	COG0612	Peptidase, M16
HVY54_12080	COG0076	glutamate decarboxylase activity
HVY54_12085	COG0531	amino acid
HVY54_12100	COG3706	GGDEF domain
HVY54_12105	COG2199	diguanylate cyclase activity
HVY54_12105	COG2202	Pas domain
HVY54_12105	COG2200	EAL domain
HVY54_12110	COG2173	Catalyzes hydrolysis of the D-alanyl-D-alanine dipeptide
HVY54_12115	COG0747	negative chemotaxis
HVY54_12125	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HVY54_12130	COG0444	Belongs to the ABC transporter superfamily
HVY54_12135	COG4608	Belongs to the ABC transporter superfamily
HVY54_12145	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HVY54_12150	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HVY54_12160	COG1250	3-hydroxyacyl-CoA dehydrogenase
HVY54_12165	COG2610	gluconate transmembrane transporter activity
HVY54_12170	COG1028	Short-chain dehydrogenase reductase Sdr
HVY54_12175	COG1764	response to oxidative stress
HVY54_12195	COG1064	alcohol dehydrogenase
HVY54_12200	COG3093	addiction module antidote protein HigA
HVY54_12205	COG2864	formate dehydrogenase
HVY54_12210	COG0437	4 iron, 4 sulfur cluster binding
HVY54_12220	COG0697	spore germination
HVY54_12230	COG4886	Leucine-rich repeat (LRR) protein
HVY54_12235	COG4886	Leucine-rich repeat (LRR) protein
HVY54_12240	COG2223	nitrite transmembrane transporter activity
HVY54_12245	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
HVY54_12250	COG1140	nitrate reductase beta subunit
HVY54_12255	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
HVY54_12260	COG2181	nitrate reductase activity
HVY54_12265	COG0384	phenazine biosynthesis protein PhzF
HVY54_12270	COG2162	N-hydroxyarylamine O-acetyltransferase activity
HVY54_12275	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HVY54_12285	COG5433	transposase activity
HVY54_12320	COG3501	Rhs element vgr protein
HVY54_12330	COG0625	glutathione transferase activity
HVY54_12335	COG1113	amino acid transport
HVY54_12340	COG3391	amine dehydrogenase activity
HVY54_12345	COG4772	TonB-dependent receptor
HVY54_12350	COG1802	Transcriptional regulator
HVY54_12355	COG2130	NADP-dependent
HVY54_12360	COG1247	-acetyltransferase
HVY54_12365	COG3238	Protein conserved in bacteria
HVY54_12395	COG1177	transmembrane transport
HVY54_12400	COG1176	ABC-type spermidine putrescine transport system, permease component I
HVY54_12405	COG3842	ATPase activity
HVY54_12410	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HVY54_12415	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HVY54_12420	COG1598	PFAM Uncharacterised protein family UPF0150
HVY54_12425	COG1724	mRNA binding
HVY54_12435	COG0826	peptidase U32
HVY54_12440	COG1396	sequence-specific DNA binding
HVY54_12445	COG3135	benzoate transporter
HVY54_12450	COG0675	Transposase, IS605 OrfB family
HVY54_12465	COG0500	methyltransferase
HVY54_12470	COG1275	C4-dicarboxylate transporter malic acid transport protein
HVY54_12475	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HVY54_12480	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HVY54_12485	COG2841	Protein conserved in bacteria
HVY54_12495	COG5383	Protein conserved in bacteria
HVY54_12500	COG0583	DNA-binding transcription factor activity
HVY54_12505	COG0840	transmembrane signaling receptor activity
HVY54_12520	COG3038	cytochrome b561
HVY54_12525	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HVY54_12530	COG1012	belongs to the aldehyde dehydrogenase family
HVY54_12535	COG1434	Gram-negative-bacterium-type cell wall biogenesis
HVY54_12540	COG1643	Atp-dependent helicase
HVY54_12550	COG0671	phosphoesterase, PA-phosphatase related
HVY54_12550	COG2453	phosphatase
HVY54_12555	COG2267	carboxylic ester hydrolase activity
HVY54_12560	COG4589	Belongs to the CDS family
HVY54_12565	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HVY54_12575	COG0667	Aldo Keto reductase
HVY54_12590	COG3784	Protein of unknown function (DUF1318)
HVY54_12600	COG2911	Protein conserved in bacteria
HVY54_12605	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HVY54_12610	COG3187	Heat shock protein
HVY54_12615	COG3042	response to heat
HVY54_12620	COG0674	pyruvate-flavodoxin oxidoreductase activity
HVY54_12620	COG1013	pyruvate-flavodoxin oxidoreductase activity
HVY54_12620	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HVY54_12620	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HVY54_12625	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HVY54_12630	COG0589	response to stress
HVY54_12640	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HVY54_12650	COG3772	lysozyme
HVY54_12665	COG3064	Membrane
HVY54_12735	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HVY54_12740	COG3723	Recombinational DNA repair protein, rece pathway
HVY54_12760	COG0582	viral genome integration into host DNA
HVY54_12770	COG0513	Belongs to the DEAD box helicase family
HVY54_12785	COG3706	GGDEF domain
HVY54_12790	COG2840	Smr protein MutS2
HVY54_12795	COG0583	DNA-binding transcription factor activity
HVY54_12800	COG1473	amidohydrolase
HVY54_12810	COG2978	secondary active p-aminobenzoyl-glutamate transmembrane transporter activity
HVY54_12815	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HVY54_12820	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HVY54_12825	COG0589	response to stress
HVY54_12830	COG3182	Iron-regulated membrane protein
HVY54_12835	COG0668	transmembrane transport
HVY54_12840	COG4166	transmembrane transport
HVY54_12845	COG0583	DNA-binding transcription factor activity
HVY54_12850	COG1073	alpha beta
HVY54_12855	COG1073	alpha beta
HVY54_12860	COG0702	epimerase
HVY54_12865	COG2866	Carboxypeptidase
HVY54_12870	COG4948	Mandelate Racemase Muconate Lactonizing
HVY54_12875	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
HVY54_12880	COG3283	Transcriptional regulator of aromatic amino acids metabolism
HVY54_12890	COG3106	COG3106 Predicted ATPase
HVY54_12895	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HVY54_12905	COG1983	PspC domain protein
HVY54_12915	COG1842	Phage shock protein A
HVY54_12920	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
HVY54_12925	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HVY54_12930	COG0665	tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity
HVY54_12935	COG1012	belongs to the aldehyde dehydrogenase family
HVY54_12940	COG1396	sequence-specific DNA binding
HVY54_12940	COG1917	Cupin 2, conserved barrel domain protein
HVY54_12945	COG2071	gamma-glutamyl-gamma-aminobutyrate hydrolase activity
HVY54_12950	COG0174	glutamine synthetase
HVY54_12960	COG0531	amino acid
HVY54_12970	COG4166	transmembrane transport
HVY54_12975	COG4168	peptide transport system, permease
HVY54_12980	COG4171	peptide transport system, permease
HVY54_12985	COG4172	Belongs to the ABC transporter superfamily
HVY54_12990	COG4172	Belongs to the ABC transporter superfamily
HVY54_12995	COG2814	Major facilitator Superfamily
HVY54_13010	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HVY54_13020	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HVY54_13025	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HVY54_13025	COG4950	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HVY54_13040	COG5001	Diguanylate cyclase
HVY54_13050	COG1349	DNA-binding transcription factor activity
HVY54_13060	COG0023	Translation Initiation Factor
HVY54_13070	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
HVY54_13075	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
HVY54_13080	COG0671	phosphoesterase, PA-phosphatase related
HVY54_13090	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HVY54_13110	COG0583	DNA-binding transcription factor activity
HVY54_13115	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HVY54_13125	COG0616	signal peptide processing
HVY54_13130	COG1028	Short-chain dehydrogenase reductase Sdr
HVY54_13135	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
HVY54_13140	COG1187	pseudouridine synthase activity
HVY54_13145	COG4907	membrane protein (DUF2207)
HVY54_13150	COG0009	L-threonylcarbamoyladenylate synthase
HVY54_13155	COG0613	PHP domain protein
HVY54_13165	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HVY54_13170	COG0512	Glutamine amidotransferase of anthranilate synthase
HVY54_13170	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HVY54_13175	COG0135	phosphoribosylanthranilate isomerase activity
HVY54_13175	COG0134	indole-3-glycerol-phosphate synthase activity
HVY54_13190	COG3729	General stress protein
HVY54_13195	COG3685	Protein conserved in bacteria
HVY54_13200	COG3685	Protein conserved in bacteria
HVY54_13205	COG3047	cAMP biosynthetic process
HVY54_13225	COG1607	acyl-coa hydrolase
HVY54_13230	COG0810	Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates. It could act to transduce energy from the cytoplasmic membrane to specific energy- requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins
HVY54_13235	COG2350	Protein conserved in bacteria
HVY54_13240	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HVY54_13260	COG4608	Belongs to the ABC transporter superfamily
HVY54_13265	COG0444	Belongs to the ABC transporter superfamily
HVY54_13270	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HVY54_13275	COG0601	transmembrane transport
HVY54_13280	COG4166	transmembrane transport
HVY54_13285	COG2095	MarC family integral membrane protein
HVY54_13290	COG1012	belongs to the aldehyde dehydrogenase family
HVY54_13290	COG1454	alcohol dehydrogenase
HVY54_13295	COG3385	transposase activity
HVY54_13300	COG1435	thymidine kinase activity
HVY54_13310	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HVY54_13315	COG0745	RESPONSE REGULATOR receiver
HVY54_13320	COG1752	Esterase of the alpha-beta hydrolase superfamily
HVY54_13330	COG0788	formyltetrahydrofolate deformylase activity
HVY54_13350	COG2181	nitrate reductase activity
HVY54_13355	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
HVY54_13360	COG1140	nitrate reductase beta subunit
HVY54_13365	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
HVY54_13370	COG2223	nitrite transmembrane transporter activity
HVY54_13375	COG3850	Histidine kinase
HVY54_13380	COG2197	response regulator
HVY54_13385	COG4932	domain protein
HVY54_13390	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
HVY54_13395	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
HVY54_13400	COG4572	Cation transport regulator
HVY54_13405	COG0387	Pfam Sodium calcium exchanger
HVY54_13425	COG2912	Transglutaminase-like superfamily
HVY54_13430	COG3094	Invasion gene expression up-regulator, SirB
HVY54_13435	COG2890	protein-(glutamine-N5) methyltransferase activity
HVY54_13460	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HVY54_13465	COG0659	secondary active sulfate transmembrane transporter activity
HVY54_13480	COG0012	GTP binding
HVY54_13490	COG3284	Transcriptional regulator
HVY54_13495	COG2376	Dihydroxyacetone kinase
HVY54_13500	COG1461	Dihydroxyacetone kinase
HVY54_13505	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HVY54_13505	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HVY54_13505	COG3412	dihydroxyacetone kinase, phosphotransfer subunit
HVY54_13525	COG1120	ATPase activity
HVY54_13530	COG0500	methyltransferase
HVY54_13535	COG0157	Belongs to the NadC ModD family
HVY54_13550	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
HVY54_13560	COG1619	proteins homologs of microcin C7 resistance protein MccF
HVY54_13580	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HVY54_13590	COG2719	SpoVR family
HVY54_13605	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
HVY54_13610	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HVY54_13615	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HVY54_13630	COG0179	Fumarylacetoacetate (FAA) hydrolase
HVY54_13655	COG2894	cell division
HVY54_13710	COG2200	EAL domain
HVY54_13735	COG2200	EAL domain
HVY54_13740	COG0789	Transcriptional regulator
HVY54_13745	COG5562	phage envelope protein
HVY54_13765	COG0538	isocitrate dehydrogenase activity
HVY54_13770	COG1187	pseudouridine synthase activity
HVY54_13790	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HVY54_13800	COG2205	protein histidine kinase activity
HVY54_13805	COG2850	peptidyl-arginine hydroxylation
HVY54_13815	COG3842	ATPase activity
HVY54_13825	COG1177	transmembrane transport
HVY54_13830	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HVY54_13835	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HVY54_13845	COG4591	ABC-type transport system involved in lipoprotein release permease component
HVY54_13850	COG1136	(ABC) transporter
HVY54_13855	COG4591	ABC-type transport system involved in lipoprotein release permease component
HVY54_13860	COG4763	Acyl-transferase
HVY54_13865	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HVY54_13870	COG1376	ErfK ybiS ycfS ynhG family protein
HVY54_13870	COG1388	LysM domain
HVY54_13880	COG1309	transcriptional regulator
HVY54_13885	COG3134	Outer membrane lipoprotein
HVY54_13890	COG1252	NADH dehydrogenase
HVY54_13905	COG0510	thiamine kinase activity
HVY54_13910	COG3417	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)
HVY54_13915	COG5633	Lipoprotein
HVY54_13920	COG0537	adenosine 5'-monophosphoramidase activity
HVY54_13925	COG4773	Receptor
HVY54_13930	COG1263	PTS System
HVY54_13930	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HVY54_13935	COG0084	hydrolase, TatD family'
HVY54_13940	COG0470	DNA polymerase III
HVY54_13950	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HVY54_13955	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HVY54_13960	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HVY54_13970	COG1028	Short-chain dehydrogenase reductase Sdr
HVY54_13975	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HVY54_13995	COG1399	metal-binding, possibly nucleic acid-binding protein
HVY54_14000	COG0424	maF-like protein
HVY54_14005	COG0564	pseudouridine synthase activity
HVY54_14010	COG1530	ribonuclease E activity
HVY54_14015	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HVY54_14020	COG1256	bacterial-type flagellum assembly
HVY54_14025	COG1705	Flagellar rod assembly protein muramidase FlgJ
HVY54_14025	COG3951	Flagellar rod assembly protein muramidase FlgJ
HVY54_14040	COG4786	Flagellar basal body rod
HVY54_14045	COG4787	bacterial-type flagellum-dependent cell motility
HVY54_14050	COG1749	Flagellar hook protein flgE
HVY54_14055	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
HVY54_14060	COG1558	bacterial-type flagellum-dependent cell motility
HVY54_14065	COG1815	bacterial-type flagellum-dependent cell motility
HVY54_14070	COG1261	Involved in the assembly process of the P-ring formation. It may associate with FlgF on the rod constituting a structure essential for the P-ring assembly or may act as a modulator protein for the P-ring assembly
HVY54_14075	COG2747	anti-sigma28 factor FlgM
HVY54_14080	COG3418	PFAM FlgN family protein
HVY54_14085	COG0728	peptidoglycan biosynthetic process
HVY54_14090	COG0673	inositol 2-dehydrogenase activity
HVY54_14100	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HVY54_14110	COG2999	glutathione oxidoreductase activity
HVY54_14150	COG3038	cytochrome b561
HVY54_14155	COG2353	YceI-like domain
HVY54_14165	COG1560	Kdo2-lipid A biosynthetic process
HVY54_14180	COG5645	(Lipo)protein
HVY54_14185	COG3385	transposase activity
HVY54_14190	COG2943	transferase activity, transferring hexosyl groups
HVY54_14205	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HVY54_14210	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
HVY54_14235	COG2197	response regulator
HVY54_14250	COG1462	curli production assembly transport component CsgG
HVY54_14260	COG3381	protein complex oligomerization
HVY54_14325	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HVY54_14330	COG0404	The glycine cleavage system catalyzes the degradation of glycine
HVY54_14340	COG0764	3-hydroxyoctanoyl-[acyl-carrier-protein] dehydratase activity
HVY54_14350	COG0736	holo-[acyl-carrier-protein] synthase activity
HVY54_14355	COG2831	hemolysin activation secretion protein
HVY54_14360	COG3210	domain, Protein
HVY54_14370	COG3539	Fimbrial protein
HVY54_14380	COG3188	usher protein
HVY54_14390	COG3121	Chaperone
HVY54_14395	COG1028	Short-chain dehydrogenase reductase Sdr
HVY54_14410	COG2200	EAL domain
HVY54_14415	COG3706	GGDEF domain
HVY54_14420	COG0457	Tetratricopeptide repeat
HVY54_14425	COG1649	PFAM Uncharacterised BCR, COG1649
HVY54_14425	COG0726	polysaccharide deacetylase
HVY54_14430	COG1215	transferase activity, transferring glycosyl groups
HVY54_14435	COG3658	cytochrome
HVY54_14440	COG1702	phosphate starvation-inducible protein PhoH
HVY54_14450	COG2822	iron ion transport
HVY54_14465	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HVY54_14475	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HVY54_14475	COG0506	proline dehydrogenase activity
HVY54_14475	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HVY54_14480	COG1309	transcriptional regulator
HVY54_14515	COG2233	PERMEase
HVY54_14520	COG3729	General stress protein
HVY54_14560	COG0243	molybdopterin cofactor binding
HVY54_14565	COG3005	denitrification pathway
HVY54_14570	COG0745	RESPONSE REGULATOR receiver
HVY54_14575	COG1879	ABC-type sugar transport system periplasmic component
HVY54_14580	COG2198	Histidine kinase
HVY54_14580	COG2205	protein histidine kinase activity
HVY54_14580	COG0784	Response regulator, receiver
HVY54_14585	COG0348	domain, Protein
HVY54_14605	COG1278	Cold shock
HVY54_14610	COG1278	Cold shock
HVY54_14630	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HVY54_14635	COG1596	polysaccharide export
HVY54_14640	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HVY54_14645	COG3206	protein involved in exopolysaccharide biosynthesis
HVY54_14645	COG0489	protein tyrosine kinase activity
HVY54_14660	COG1294	oxidase, subunit
HVY54_14665	COG1271	oxidase subunit
HVY54_14670	COG1773	rubredoxin
HVY54_14675	COG1999	signal sequence binding
HVY54_14680	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
HVY54_14685	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
HVY54_14690	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
HVY54_14695	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
HVY54_14705	COG0670	Belongs to the BI1 family
HVY54_14710	COG2920	part of a sulfur-relay system
HVY54_14715	COG1254	Belongs to the acylphosphatase family
HVY54_14730	COG1832	CoA-binding protein
HVY54_14745	COG0210	DNA helicase
HVY54_14750	COG3304	Inner membrane component domain
HVY54_14755	COG1289	transmembrane transporter activity
HVY54_14760	COG3070	regulator of competence-specific genes
HVY54_14780	COG1067	ATP-dependent peptidase activity
HVY54_14790	COG3130	regulation of translation
HVY54_14795	COG3009	Protein conserved in bacteria
HVY54_14800	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HVY54_14800	COG3008	intermembrane lipid transfer
HVY54_14805	COG2995	paraquat-inducible protein a
HVY54_14810	COG0488	(ABC) transporter
HVY54_14820	COG0633	Ferredoxin
HVY54_14820	COG3217	Mosc domain protein beta barrel domain protein
HVY54_14835	COG3121	Chaperone
HVY54_14840	COG3539	Fimbrial protein
HVY54_14845	COG3539	Fimbrial protein
HVY54_14850	COG3539	Fimbrial protein
HVY54_14855	COG3188	usher protein
HVY54_14860	COG3121	Chaperone
HVY54_14865	COG3539	Fimbrial protein
HVY54_14870	COG0431	NADPH-dependent FMN reductase
HVY54_14875	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HVY54_14885	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HVY54_14890	COG1116	anion transmembrane transporter activity
HVY54_14895	COG0308	aminopeptidase N
HVY54_14910	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HVY54_14915	COG1448	Aminotransferase
HVY54_14920	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HVY54_14925	COG3108	Peptidase M15
HVY54_14930	COG2989	Protein conserved in bacteria
HVY54_14940	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
HVY54_14950	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HVY54_14955	COG1434	Gram-negative-bacterium-type cell wall biogenesis
HVY54_14960	COG3173	Aminoglycoside phosphotransferase
HVY54_14975	COG3214	Protein conserved in bacteria
HVY54_14985	COG1132	(ABC) transporter
HVY54_15000	COG0539	negative regulation of cytoplasmic translation
HVY54_15010	COG0501	Belongs to the peptidase M48B family
HVY54_15025	COG2323	membrane
HVY54_15030	COG1944	ATP diphosphatase activity
HVY54_15035	COG2116	formate transmembrane transporter activity
HVY54_15040	COG1882	Formate acetyltransferase
HVY54_15180	COG4695	Portal protein
HVY54_15245	COG4974	Belongs to the 'phage' integrase family
HVY54_15250	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HVY54_15260	COG0531	amino acid
HVY54_15270	COG1335	isochorismatase
HVY54_15275	COG3302	dmso reductase anchor subunit
HVY54_15280	COG0437	4 iron, 4 sulfur cluster binding
HVY54_15285	COG0243	molybdopterin cofactor binding
HVY54_15295	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HVY54_15310	COG1522	sequence-specific DNA binding
HVY54_15315	COG0492	ferredoxin-NADP+ reductase activity
HVY54_15320	COG4988	ABC transporter
HVY54_15325	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
HVY54_15345	COG0542	response to heat
HVY54_15355	COG1278	Cold shock
HVY54_15360	COG0577	efflux transmembrane transporter activity
HVY54_15360	COG1136	(ABC) transporter
HVY54_15365	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HVY54_15370	COG2990	Protein conserved in bacteria
HVY54_15375	COG3593	DNA synthesis involved in DNA repair
HVY54_15380	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HVY54_15385	COG2431	L-lysine efflux transmembrane transporter activity
HVY54_15395	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HVY54_15400	COG0028	Belongs to the TPP enzyme family
HVY54_15405	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
HVY54_15410	COG0702	epimerase
HVY54_15415	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HVY54_15420	COG3023	N-Acetylmuramoyl-L-alanine amidase
HVY54_15440	COG1126	abc transporter atp-binding protein
HVY54_15445	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HVY54_15450	COG4215	(ABC) transporter
HVY54_15455	COG4160	amino acid transport
HVY54_15460	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HVY54_15490	COG1177	transmembrane transport
HVY54_15495	COG1176	ABC-type spermidine putrescine transport system, permease component I
HVY54_15500	COG3842	ATPase activity
HVY54_15505	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HVY54_15520	COG0778	Nitroreductase
HVY54_15530	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HVY54_15545	COG3226	Transcriptional regulator
HVY54_15550	COG0738	Major facilitator superfamily
HVY54_15555	COG0561	phosphatase activity
HVY54_15565	COG2814	Major facilitator Superfamily
HVY54_15570	COG0671	phosphoesterase, PA-phosphatase related
HVY54_15575	COG1349	DNA-binding transcription factor activity
HVY54_15580	COG1686	Belongs to the peptidase S11 family
HVY54_15585	COG0625	glutathione transferase activity
HVY54_15590	COG2133	pyrroloquinoline quinone binding
HVY54_15615	COG2199	diguanylate cyclase activity
HVY54_15620	COG2200	EAL domain
HVY54_15625	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HVY54_15635	COG0747	negative chemotaxis
HVY54_15645	COG1446	asparaginase
HVY54_15650	COG0303	'Molybdopterin
HVY54_15655	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HVY54_15660	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HVY54_15665	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HVY54_15670	COG1882	Formate acetyltransferase
HVY54_15675	COG0561	phosphatase activity
HVY54_15685	COG0488	(ABC) transporter
HVY54_15690	COG1376	ErfK ybiS ycfS ynhG family protein
HVY54_15695	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HVY54_15700	COG1321	iron dependent repressor
HVY54_15710	COG2194	sulfuric ester hydrolase activity
HVY54_15715	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
HVY54_15725	COG5006	permease, DMT superfamily
HVY54_15735	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HVY54_15740	COG0765	amino acid transport
HVY54_15745	COG1126	abc transporter atp-binding protein
HVY54_15750	COG0668	transmembrane transport
HVY54_15765	COG4774	siderophore transport
HVY54_15775	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HVY54_15785	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
HVY54_15790	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HVY54_15795	COG1199	ATP-dependent helicase activity
HVY54_15805	COG0513	Belongs to the DEAD box helicase family
HVY54_15810	COG1309	transcriptional regulator
HVY54_15820	COG1131	(ABC) transporter
HVY54_15825	COG0842	Transport permease protein
HVY54_15830	COG0842	Transport permease protein
HVY54_15840	COG3568	Endonuclease Exonuclease Phosphatase
HVY54_15845	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HVY54_15850	COG0392	lysyltransferase activity
HVY54_15855	COG0670	Belongs to the BI1 family
HVY54_15860	COG0670	Belongs to the BI1 family
HVY54_15865	COG0314	molybdopterin synthase activity
HVY54_15870	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
HVY54_15880	COG0521	Mo-molybdopterin cofactor biosynthetic process
HVY54_15890	COG0391	Required for morphogenesis under gluconeogenic growth conditions
HVY54_15900	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HVY54_15905	COG2226	methyltransferase
HVY54_15920	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HVY54_15925	COG1881	PFAM PEBP family protein
HVY54_15930	COG2199	diguanylate cyclase activity
HVY54_15935	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
HVY54_15940	COG5301	cellulose 1,4-beta-cellobiosidase activity
HVY54_15975	COG1196	nuclear chromosome segregation
HVY54_16025	COG1030	water channel activity
HVY54_16040	COG4220	transposase activity
HVY54_16135	COG4220	transposase activity
HVY54_16145	COG5562	phage envelope protein
HVY54_16150	COG3646	Phage regulatory protein
HVY54_16165	COG3772	lysozyme
HVY54_16325	COG0582	viral genome integration into host DNA
HVY54_16330	COG4677	pectinesterase activity
HVY54_16335	COG1048	Catalyzes the isomerization of citrate to isocitrate via cis-aconitate
HVY54_16340	COG0471	metal ion transport
HVY54_16345	COG2828	Protein conserved in bacteria
HVY54_16350	COG0583	DNA-binding transcription factor activity
HVY54_16360	COG0561	phosphatase activity
HVY54_16370	COG4149	molybdate abc transporter
HVY54_16375	COG0725	ABC transporter, periplasmic molybdate-binding protein
HVY54_16385	COG3585	molybdate ion transport
HVY54_16385	COG2005	Transcriptional regulator
HVY54_16390	COG1119	ATPase activity
HVY54_16395	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HVY54_16400	COG1085	galactose-1-phosphate uridylyltransferase
HVY54_16410	COG2017	converts alpha-aldose to the beta-anomer
HVY54_16420	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HVY54_16430	COG1230	cation diffusion facilitator family transporter
HVY54_16435	COG3201	nicotinamide mononucleotide transporter
HVY54_16485	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
HVY54_16490	COG2885	chlorophyll binding
HVY54_16500	COG3064	Membrane
HVY54_16505	COG0848	biopolymer transport protein
HVY54_16510	COG0811	peptide transport
HVY54_16515	COG0824	Thioesterase
HVY54_16520	COG3790	cyd operon protein YbgE
HVY54_16525	COG4890	Cyd operon protein YbgT
HVY54_16530	COG1294	oxidase, subunit
HVY54_16535	COG1271	oxidase subunit
HVY54_16550	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HVY54_16560	COG4865	methylaspartate mutase activity
HVY54_16565	COG3799	methylaspartate ammonia-lyase activity
HVY54_16580	COG1301	dicarboxylic acid transport
HVY54_16585	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HVY54_16585	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
HVY54_16590	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
HVY54_16595	COG0583	DNA-binding transcription factor activity
HVY54_16600	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HVY54_16610	COG0508	dehydrogenase complex catalyzes the overall conversion of
HVY54_16615	COG0567	Dehydrogenase, E1 component
HVY54_16620	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HVY54_16625	COG1053	succinate dehydrogenase
HVY54_16630	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
HVY54_16635	COG2009	succinate dehydrogenase
HVY54_16645	COG0372	Belongs to the citrate synthase family
HVY54_16650	COG3539	Fimbrial protein
HVY54_16655	COG3188	usher protein
HVY54_16660	COG3121	Chaperone
HVY54_16665	COG3539	Fimbrial protein
HVY54_16670	COG3180	Ammonia monooxygenase
HVY54_16685	COG1984	allophanate hydrolase subunit 2
HVY54_16690	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
HVY54_16695	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HVY54_16705	COG0415	Belongs to the DNA photolyase family
HVY54_16710	COG3272	Protein of unknown function (DUF1722)
HVY54_16740	COG2205	protein histidine kinase activity
HVY54_16745	COG0745	RESPONSE REGULATOR receiver
HVY54_16755	COG1982	Orn Lys Arg decarboxylase major
HVY54_16760	COG0531	amino acid
HVY54_16765	COG0033	Phosphoglucomutase
HVY54_16770	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
HVY54_16775	COG0596	Alpha beta hydrolase
HVY54_16785	COG0716	FMN binding
HVY54_16795	COG0735	belongs to the Fur family
HVY54_16815	COG1263	PTS System
HVY54_16815	COG2190	(PTS) system
HVY54_16815	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HVY54_16825	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HVY54_16830	COG1846	Transcriptional regulator
HVY54_16830	COG1940	carbohydrate kinase activity
HVY54_16835	COG0647	UMP catabolic process
HVY54_16840	COG0367	asparagine synthase
HVY54_16880	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HVY54_16890	COG1702	phosphate starvation-inducible protein PhoH
HVY54_16900	COG4535	Mg2 and Co2 transporter CorC
HVY54_16905	COG0815	Transfers the fatty acyl group on membrane lipoproteins
HVY54_16910	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HVY54_16915	COG0765	amino acid transport
HVY54_16920	COG0765	amino acid transport
HVY54_16925	COG1126	abc transporter atp-binding protein
HVY54_16935	COG0443	Heat shock 70 kDa protein
HVY54_16950	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
HVY54_16955	COG2214	Heat shock protein DnaJ domain protein
HVY54_16965	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
HVY54_16970	COG2888	peptidyl-tyrosine sulfation
HVY54_16985	COG1466	dna polymerase III delta subunit
HVY54_16995	COG0406	alpha-ribazole phosphatase activity
HVY54_17000	COG0799	negative regulation of ribosome biogenesis
HVY54_17010	COG0768	penicillin binding
HVY54_17015	COG0772	Belongs to the SEDS family
HVY54_17020	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HVY54_17025	COG1686	Belongs to the peptidase S11 family
HVY54_17040	COG0583	DNA-binding transcription factor activity
HVY54_17050	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HVY54_17055	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HVY54_17075	COG3069	C4-dicarboxylate transmembrane transporter activity
HVY54_17080	COG4565	transcriptional regulatory protein
HVY54_17085	COG3290	protein histidine kinase activity
HVY54_17090	COG3053	Acetylation of prosthetic group (2-(5''-phosphoribosyl)- 3'-dephosphocoenzyme-A) of the gamma subunit of citrate lyase
HVY54_17100	COG2301	Belongs to the HpcH HpaI aldolase family
HVY54_17105	COG3051	citrate lyase alpha subunit
HVY54_17120	COG0471	metal ion transport
HVY54_17125	COG3719	Belongs to the RNase T2 family
HVY54_17130	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HVY54_17135	COG1063	alcohol dehydrogenase
HVY54_17140	COG0589	response to stress
HVY54_17145	COG3634	alkyl hydroperoxide reductase activity
HVY54_17150	COG0450	alkyl hydroperoxide reductase
HVY54_17155	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HVY54_17160	COG0583	DNA-binding transcription factor activity
HVY54_17165	COG3969	phosphoadenosine phosphosulfate
HVY54_17170	COG1475	DNA binding
HVY54_17175	COG0436	Aminotransferase
HVY54_17180	COG0371	Dehydrogenase
HVY54_17185	COG2879	small protein
HVY54_17190	COG1966	Carbon starvation protein
HVY54_17195	COG2050	protein possibly involved in aromatic compounds catabolism
HVY54_17200	COG1028	Short-chain dehydrogenase reductase Sdr
HVY54_17205	COG1535	isochorismatase
HVY54_17205	COG3433	isochorismatase activity
HVY54_17210	COG1021	2,3-dihydroxybenzoate-AMP ligase
HVY54_17215	COG1169	isochorismate synthase
HVY54_17220	COG4592	Periplasmic binding protein
HVY54_17230	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HVY54_17235	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HVY54_17240	COG1120	ATPase activity
HVY54_17245	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
HVY54_17250	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
HVY54_17250	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HVY54_17255	COG3251	PFAM MbtH domain protein
HVY54_17260	COG2382	esterase
HVY54_17265	COG4771	TonB-dependent receptor
HVY54_17270	COG2977	Belongs to the P-Pant transferase superfamily
HVY54_17295	COG2315	Protein conserved in bacteria
HVY54_17300	COG0778	Nitroreductase
HVY54_17305	COG0668	transmembrane transport
HVY54_17310	COG1113	amino acid transport
HVY54_17315	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HVY54_17320	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HVY54_17325	COG5569	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HVY54_17330	COG1538	Outer membrane efflux protein
HVY54_17335	COG0745	RESPONSE REGULATOR receiver
HVY54_17340	COG5002	protein histidine kinase activity
HVY54_17350	COG4783	chaperone-mediated protein folding
HVY54_17360	COG2207	Transcriptional regulator
HVY54_17385	COG3539	Fimbrial protein
HVY54_17390	COG3539	Fimbrial protein
HVY54_17395	COG3188	usher protein
HVY54_17400	COG3121	Chaperone
HVY54_17405	COG3539	Fimbrial protein
HVY54_17415	COG2501	S4 domain
HVY54_17420	COG1988	membrane-bound metal-dependent
HVY54_17430	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HVY54_17440	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HVY54_17445	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HVY54_17450	COG0549	Belongs to the carbamate kinase family
HVY54_17460	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HVY54_17465	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HVY54_17470	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
HVY54_17475	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HVY54_17480	COG3257	ureidoglycine aminohydrolase activity
HVY54_17485	COG1929	Belongs to the glycerate kinase type-1 family
HVY54_17490	COG2233	PERMEase
HVY54_17500	COG1953	Uracil, thiamine, allantoin
HVY54_17505	COG2084	Dehydrogenase
HVY54_17510	COG3622	Belongs to the hyi family
HVY54_17515	COG3960	tartronate-semialdehyde synthase activity
HVY54_17520	COG1414	Transcriptional regulator
HVY54_17530	COG0583	DNA-binding transcription factor activity
HVY54_17550	COG3209	COG3209 Rhs family protein
HVY54_17555	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
HVY54_17560	COG4181	ATPase activity
HVY54_17565	COG2755	lipolytic protein G-D-S-L family
HVY54_17570	COG0300	oxidoreductase activity
HVY54_17575	COG3118	belongs to the thioredoxin family
HVY54_17580	COG0390	transport system, permease component
HVY54_17585	COG4619	ABC transporter
HVY54_17590	COG0330	HflC and HflK could
HVY54_17595	COG1585	Membrane protein implicated in regulation of membrane protease activity
HVY54_17620	COG0789	Transcriptional regulator
HVY54_17630	COG1132	(ABC) transporter
HVY54_17650	COG0531	amino acid
HVY54_17660	COG2217	Heavy metal translocating P-type atpase
HVY54_17665	COG3093	addiction module antidote protein HigA
HVY54_17670	COG3735	TraB family
HVY54_17675	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HVY54_17680	COG0737	Belongs to the 5'-nucleotidase family
HVY54_17685	COG2223	nitrite transmembrane transporter activity
HVY54_17690	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HVY54_17690	COG4651	solute:proton antiporter activity
HVY54_17695	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HVY54_17730	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HVY54_17740	COG2832	Protein of unknown function (DUF454)
HVY54_17745	COG3923	Primosomal replication protein n
HVY54_17755	COG1196	nuclear chromosome segregation
HVY54_17755	COG3264	Mechanosensitive ion channel
HVY54_17760	COG1309	transcriptional regulator
HVY54_17765	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HVY54_17770	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HVY54_17785	COG0110	maltose O-acetyltransferase activity
HVY54_17795	COG4943	cyclic-guanylate-specific phosphodiesterase activity
HVY54_17800	COG5507	3-demethylubiquinone-9 3-methyltransferase
HVY54_17810	COG3695	enzyme binding
HVY54_17815	COG3126	Type III secretion system lipoprotein chaperone (YscW)
HVY54_17820	COG1946	Acyl-CoA thioesterase
HVY54_17825	COG0004	ammonium transporteR
HVY54_17830	COG0347	Belongs to the P(II) protein family
HVY54_17835	COG1132	(ABC) transporter
HVY54_17840	COG1132	(ABC) transporter
HVY54_17845	COG1522	sequence-specific DNA binding
HVY54_17855	COG4533	DNA binding
HVY54_17865	COG0824	Thioesterase
HVY54_17870	COG1555	photosystem II stabilization
HVY54_17875	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HVY54_17880	COG0776	regulation of translation
HVY54_17885	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HVY54_17905	COG0271	Belongs to the BolA IbaG family
HVY54_17910	COG3056	Lipoprotein
HVY54_17915	COG2223	nitrite transmembrane transporter activity
HVY54_17920	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HVY54_17925	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HVY54_17930	COG1845	cytochrome c oxidase, subunit III
HVY54_17935	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
HVY54_17945	COG2814	Major facilitator Superfamily
HVY54_17955	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HVY54_17960	COG0693	protein deglycase activity
HVY54_17975	COG0142	geranyltranstransferase activity
HVY54_17985	COG0667	Aldo Keto reductase
HVY54_17995	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HVY54_18000	COG0611	Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1
HVY54_18015	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HVY54_18015	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HVY54_18025	COG4238	major outer membrane lipoprotein
HVY54_18030	COG3248	Nucleoside-binding outer membrane protein
HVY54_18035	COG1403	HNH endonuclease
HVY54_18040	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HVY54_18045	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HVY54_18050	COG1862	Preprotein translocase
HVY54_18075	COG0366	Alpha amylase catalytic
HVY54_18080	COG1113	amino acid transport
HVY54_18085	COG1114	Component of the transport system for branched-chain amino acids
HVY54_18090	COG5002	protein histidine kinase activity
HVY54_18095	COG0745	RESPONSE REGULATOR receiver
HVY54_18100	COG0420	3'-5' exonuclease activity
HVY54_18105	COG0419	ATPase involved in DNA repair
HVY54_18110	COG2814	Major facilitator Superfamily
HVY54_18115	COG1940	carbohydrate kinase activity
HVY54_18140	COG4126	flavin adenine dinucleotide binding
HVY54_18160	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HVY54_18165	COG3706	GGDEF domain
HVY54_18175	COG1785	Belongs to the alkaline phosphatase family
HVY54_18190	COG1181	Belongs to the D-alanine--D-alanine ligase family
HVY54_18210	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
HVY54_18215	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HVY54_18220	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HVY54_18225	COG3468	outer membrane autotransporter barrel domain protein
HVY54_18230	COG0113	porphobilinogen synthase activity
HVY54_18235	COG2175	clavaminate synthase activity
HVY54_18240	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HVY54_18250	COG4521	taurine ABC transporter
HVY54_18265	COG2271	Major facilitator Superfamily
HVY54_18270	COG1840	ABC-type Fe3 transport system, periplasmic component
HVY54_18280	COG3842	ATPase activity
HVY54_18295	COG0627	Serine hydrolase involved in the detoxification of formaldehyde
HVY54_18300	COG3122	Protein conserved in bacteria
HVY54_18305	COG2814	Major facilitator Superfamily
HVY54_18310	COG0119	Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate)
HVY54_18325	COG0596	Alpha beta hydrolase
HVY54_18340	COG1414	Transcriptional regulator
HVY54_18345	COG2220	Zn-dependent hydrolases of the beta-lactamase fold
HVY54_18355	COG1609	Transcriptional regulator
HVY54_18360	COG3250	beta-galactosidase activity
HVY54_18365	COG2223	nitrite transmembrane transporter activity
HVY54_18370	COG0110	maltose O-acetyltransferase activity
HVY54_18375	COG2807	transmembrane transport
HVY54_18385	COG0288	reversible hydration of carbon dioxide
HVY54_18390	COG0583	DNA-binding transcription factor activity
HVY54_18395	COG0402	S-adenosylhomocysteine deaminase activity
HVY54_18400	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HVY54_18405	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HVY54_18410	COG2079	MmgE PrpD family protein
HVY54_18415	COG0372	Belongs to the citrate synthase family
HVY54_18420	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
HVY54_18425	COG3829	transcription factor binding
HVY54_18435	COG1280	lysine exporter protein (LysE YggA)
HVY54_18450	COG1064	alcohol dehydrogenase
HVY54_18460	COG1172	Belongs to the binding-protein-dependent transport system permease family
HVY54_18465	COG1129	ABC transporter
HVY54_18470	COG1879	ABC-type sugar transport system periplasmic component
HVY54_18480	COG0402	S-adenosylhomocysteine deaminase activity
HVY54_18485	COG0549	Belongs to the carbamate kinase family
HVY54_18495	COG1304	FMN binding
HVY54_18500	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HVY54_18510	COG0666	response to abiotic stimulus
HVY54_18520	COG0583	DNA-binding transcription factor activity
HVY54_18525	COG2771	luxR family
HVY54_18525	COG2200	EAL domain
HVY54_18535	COG1292	Belongs to the BCCT transporter (TC 2.A.15) family
HVY54_18560	COG2771	luxR family
HVY54_18560	COG2200	EAL domain
HVY54_18580	COG1556	Lactate utilization protein
HVY54_18585	COG1139	Iron-sulfur cluster binding protein
HVY54_18590	COG0247	lactate metabolic process
HVY54_18595	COG2207	Transcriptional regulator
HVY54_18600	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HVY54_18610	COG3059	membrane
HVY54_18660	COG3188	usher protein
HVY54_18680	COG0675	Transposase, IS605 OrfB family
HVY54_18685	COG0727	PFAM Uncharacterised protein family (UPF0153)
HVY54_18690	COG3477	response to acidic pH
HVY54_18695	COG2080	2 iron, 2 sulfur cluster binding
HVY54_18700	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
HVY54_18705	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HVY54_18710	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
HVY54_18725	COG0583	DNA-binding transcription factor activity
HVY54_18735	COG4221	oxidoreductase activity
HVY54_18740	COG0583	DNA-binding transcription factor activity
HVY54_18750	COG0583	DNA-binding transcription factor activity
HVY54_18760	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HVY54_18775	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
HVY54_18800	COG4228	DNA circulation
HVY54_18825	COG5532	Uncharacterized conserved protein (DUF2303)
HVY54_18830	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
HVY54_18845	COG0582	viral genome integration into host DNA
HVY54_18865	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HVY54_18885	COG2195	Cleaves the N-terminal amino acid of tripeptides
HVY54_18890	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
HVY54_18895	COG1690	Belongs to the RtcB family
HVY54_18900	COG0454	-acetyltransferase
HVY54_18905	COG2161	toxin-antitoxin pair type II binding
HVY54_18925	COG1943	Transposase
HVY54_18930	COG0791	NLP P60 protein
HVY54_18935	COG3077	Addiction module antitoxin, RelB DinJ family
HVY54_18940	COG3041	Addiction module toxin RelE StbE family
HVY54_18945	COG3034	peptidoglycan biosynthetic process
HVY54_18950	COG0121	glutamine amidotransferase
HVY54_18960	COG1960	acyl-CoA dehydrogenase activity
HVY54_18970	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HVY54_19020	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HVY54_19030	COG2226	methyltransferase
HVY54_19040	COG0741	lytic transglycosylase activity
HVY54_19040	COG1388	LysM domain
HVY54_19045	COG2226	methyltransferase
HVY54_19055	COG0583	DNA-binding transcription factor activity
HVY54_19060	COG0656	L-ascorbic acid biosynthetic process
HVY54_19095	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HVY54_19100	COG1135	Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system
HVY54_19105	COG2011	ABC-type metal ion transport system permease component
HVY54_19110	COG1464	Belongs to the NlpA lipoprotein family
HVY54_19120	COG1720	tRNA m6t6A37 methyltransferase activity
HVY54_19130	COG0791	NLP P60 protein
HVY54_19135	COG3015	lipoprotein NlpE involved in copper resistance
HVY54_19140	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
HVY54_19145	COG4681	YaeQ
HVY54_19155	COG4568	rho-dependent transcription termination
HVY54_19160	COG0037	tRNA processing
HVY54_19165	COG0346	lactoylglutathione lyase activity
HVY54_19180	COG0587	DNA-directed DNA polymerase activity
HVY54_19205	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HVY54_19210	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
HVY54_19220	COG0750	zinc metalloprotease
HVY54_19225	COG0575	Belongs to the CDS family
HVY54_19230	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HVY54_19235	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HVY54_19260	COG0024	Methionine aminopeptidase
HVY54_19280	COG3835	regulator
HVY54_19285	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HVY54_19300	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HVY54_19305	COG2860	membrane
HVY54_19330	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HVY54_19335	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HVY54_19340	COG1120	ATPase activity
HVY54_19345	COG4774	siderophore transport
HVY54_19350	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HVY54_19355	COG1643	Atp-dependent helicase
HVY54_19360	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
HVY54_19370	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HVY54_19375	COG0008	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu)
HVY54_19380	COG0617	tRNA 3'-terminal CCA addition
HVY54_19385	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HVY54_19395	COG3121	Chaperone
HVY54_19400	COG3188	usher protein
HVY54_19405	COG3539	Fimbrial protein
HVY54_19410	COG3539	Fimbrial protein
HVY54_19435	COG5464	transposase or invertase
HVY54_19445	COG0726	polysaccharide deacetylase
HVY54_19450	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HVY54_19455	COG0842	Transport permease protein
HVY54_19460	COG1131	(ABC) transporter
HVY54_19465	COG0288	reversible hydration of carbon dioxide
HVY54_19470	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
HVY54_19475	COG4993	Dehydrogenase
HVY54_19480	COG2132	Multicopper oxidase
HVY54_19505	COG1049	propionate catabolic process, 2-methylcitrate cycle
HVY54_19510	COG3064	Membrane
HVY54_19515	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HVY54_19520	COG0508	dehydrogenase complex catalyzes the overall conversion of
HVY54_19525	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
HVY54_19530	COG2186	Transcriptional regulator
HVY54_19540	COG3725	Membrane protein required for beta-lactamase induction
HVY54_19545	COG3023	N-Acetylmuramoyl-L-alanine amidase
HVY54_19550	COG0157	Belongs to the NadC ModD family
HVY54_19555	COG4969	Belongs to the N-Me-Phe pilin family
HVY54_19560	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HVY54_19565	COG1459	type II secretion system
HVY54_19580	COG0237	dephospho-CoA kinase activity
HVY54_19595	COG0494	nUDIX hydrolase
HVY54_19615	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HVY54_19620	COG0849	cell division
HVY54_19625	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
HVY54_19630	COG1181	Belongs to the D-alanine--D-alanine ligase family
HVY54_19645	COG0772	Belongs to the SEDS family
HVY54_19650	COG0771	Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA)
HVY54_19660	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HVY54_19665	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HVY54_19670	COG0768	penicillin binding
HVY54_19675	COG3116	cell division
HVY54_19690	COG1609	Transcriptional regulator
HVY54_19700	COG0440	acetolactate synthase activity
HVY54_19705	COG0028	Belongs to the TPP enzyme family
HVY54_19710	COG0583	DNA-binding transcription factor activity
HVY54_19755	COG4143	(ABC) transporter
HVY54_19760	COG1178	ABC-type Fe3 transport system permease component
HVY54_19770	COG0586	Pfam SNARE associated Golgi protein
HVY54_19775	COG4977	sequence-specific DNA binding
HVY54_19790	COG0235	Class ii aldolase
HVY54_19795	COG0417	DNA replication proofreading
HVY54_19805	COG0564	pseudouridine synthase activity
HVY54_19810	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
HVY54_19815	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
HVY54_19820	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HVY54_19855	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HVY54_19870	COG2271	Major facilitator Superfamily
HVY54_19875	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
HVY54_19880	COG0644	oxidoreductase
HVY54_19930	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HVY54_19935	COG0505	Belongs to the CarA family
HVY54_19955	COG1047	Peptidyl-prolyl cis-trans
HVY54_19970	COG0196	riboflavin kinase activity
HVY54_19995	COG3121	Chaperone
HVY54_20000	COG3188	usher protein
HVY54_20010	COG0583	DNA-binding transcription factor activity
HVY54_20040	COG4735	regulation of single-species biofilm formation
HVY54_20045	COG1584	GPR1 FUN34 yaaH family protein
HVY54_20050	COG0521	Mo-molybdopterin cofactor biosynthetic process
HVY54_20055	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HVY54_20060	COG1115	amino acid carrier protein
HVY54_20075	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HVY54_20085	COG0527	aspartate kinase activity
HVY54_20085	COG0460	homoserine dehydrogenase
HVY54_20095	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
HVY54_20105	COG0745	RESPONSE REGULATOR receiver
HVY54_20110	COG4452	Inner membrane protein CreD
HVY54_20115	COG2205	protein histidine kinase activity
HVY54_20120	COG0745	RESPONSE REGULATOR receiver
HVY54_20125	COG3045	CreA protein
HVY54_20130	COG3708	Transcriptional regulator
HVY54_20130	COG2207	Transcriptional regulator
HVY54_20150	COG0741	lytic transglycosylase activity
HVY54_20155	COG0488	(ABC) transporter
HVY54_20160	COG3172	ATPase kinase involved in NAD metabolism
HVY54_20160	COG1056	cytidyltransferase-related domain
HVY54_20165	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HVY54_20170	COG0560	Phosphoserine phosphatase
HVY54_20175	COG3726	membrane protein affecting hemolysin expression
HVY54_20210	COG1328	CTP reductase activity
HVY54_20215	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HVY54_20220	COG0084	hydrolase, TatD family'
HVY54_20225	COG4667	esterase of the alpha-beta hydrolase superfamily
HVY54_20235	COG2823	Periplasmic or secreted lipoprotein
HVY54_20245	COG1011	Hydrolase
HVY54_20250	COG0456	acetyltransferase
HVY54_20255	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
HVY54_20285	COG4114	ferric iron reductase
HVY54_20290	COG2197	response regulator
HVY54_20295	COG2197	response regulator
HVY54_20300	COG2966	Psort location CytoplasmicMembrane, score
HVY54_20315	COG1484	DNA-dependent DNA replication
HVY54_20330	COG1063	alcohol dehydrogenase
HVY54_20335	COG1802	Transcriptional regulator
HVY54_20340	COG2271	Major facilitator Superfamily
HVY54_20345	COG0840	transmembrane signaling receptor activity
HVY54_20355	COG1966	Carbon starvation protein
HVY54_20360	COG2879	small protein
HVY54_20365	COG0523	cobalamin synthesis protein
HVY54_20385	COG0732	type I restriction modification DNA specificity domain
HVY54_20400	COG5457	Domain of unknown function (DUF1127)
HVY54_20405	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HVY54_20415	COG2814	Major facilitator Superfamily
HVY54_20420	COG2733	membrane
HVY54_20425	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
HVY54_20430	COG1924	4 iron, 4 sulfur cluster binding
HVY54_20445	COG3204	pilus organization
HVY54_20450	COG0477	Major facilitator Superfamily
HVY54_20465	COG3366	ferrous iron transmembrane transporter activity
HVY54_20470	COG0700	Nucleoside recognition
HVY54_20475	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HVY54_20480	COG0583	DNA-binding transcription factor activity
HVY54_20500	COG2186	Transcriptional regulator
HVY54_20505	COG0246	Mannitol dehydrogenase
HVY54_20520	COG3539	Fimbrial protein
HVY54_20525	COG3539	Fimbrial protein
HVY54_20530	COG3539	Fimbrial protein
HVY54_20535	COG3188	usher protein
HVY54_20540	COG3121	Chaperone
HVY54_20545	COG3539	Fimbrial protein
HVY54_20550	COG3539	Fimbrial protein
HVY54_20555	COG4974	Belongs to the 'phage' integrase family
HVY54_20560	COG0582	viral genome integration into host DNA
HVY54_20565	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
HVY54_20570	COG3055	Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses
HVY54_20625	COG3507	Belongs to the glycosyl hydrolase 43 family
HVY54_20630	COG2211	Major facilitator Superfamily
HVY54_20640	COG4580	involved in the transport of maltose and maltodextrins
HVY54_20675	COG0582	viral genome integration into host DNA
HVY54_20690	COG2194	sulfuric ester hydrolase activity
HVY54_20695	COG0582	viral genome integration into host DNA
HVY54_20705	COG1064	alcohol dehydrogenase
HVY54_20710	COG3265	gluconokinase activity
HVY54_20715	COG1063	alcohol dehydrogenase
HVY54_20720	COG1028	Short-chain dehydrogenase reductase Sdr
HVY54_20725	COG2610	gluconate transmembrane transporter activity
HVY54_20730	COG1609	Transcriptional regulator
HVY54_20735	COG0433	COG0433 Predicted ATPase
HVY54_20740	COG0795	lipopolysaccharide-transporting ATPase activity
HVY54_20745	COG0795	lipopolysaccharide-transporting ATPase activity
HVY54_20755	COG2927	DNA polymerase III (CHI subunit)
HVY54_20765	COG4269	membrane
HVY54_20770	COG0456	acetyltransferase
HVY54_20775	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
HVY54_20790	COG2731	YhcH YjgK YiaL family protein
HVY54_20795	COG1309	transcriptional regulator
HVY54_20800	COG1028	Short-chain dehydrogenase reductase Sdr
HVY54_20805	COG0251	oxidation-reduction process
HVY54_20825	COG0251	oxidation-reduction process
HVY54_20830	COG0474	ATPase, P-type transporting, HAD superfamily, subfamily IC
HVY54_20840	COG1609	Transcriptional regulator
HVY54_20845	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HVY54_20845	COG1263	PTS System
HVY54_20850	COG0366	Alpha amylase catalytic
HVY54_20855	COG1328	CTP reductase activity
HVY54_20860	COG0602	queuosine metabolic process
HVY54_20865	COG3077	Addiction module antitoxin, RelB DinJ family
HVY54_20870	COG3783	Cytochrome b(562)
HVY54_20875	COG0312	modulator of DNA gyrase
HVY54_20885	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HVY54_20895	COG1172	Belongs to the binding-protein-dependent transport system permease family
HVY54_20900	COG1172	Belongs to the binding-protein-dependent transport system permease family
HVY54_20905	COG1129	ABC transporter
HVY54_20910	COG1879	ABC-type sugar transport system periplasmic component
HVY54_20915	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HVY54_20920	COG2337	Toxic component of a toxin-antitoxin (TA) module
HVY54_20925	COG2336	PFAM SpoVT AbrB
HVY54_20930	COG2105	PFAM AIG2 family protein
HVY54_20935	COG2911	Protein conserved in bacteria
HVY54_20940	COG0729	surface antigen
HVY54_20950	COG1253	flavin adenine dinucleotide binding
HVY54_20960	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
HVY54_20970	COG1218	3'(2'),5'-bisphosphate nucleotidase
HVY54_20975	COG0737	Belongs to the 5'-nucleotidase family
HVY54_20980	COG1733	regulation of RNA biosynthetic process
HVY54_20985	COG0702	epimerase
HVY54_20990	COG0697	spore germination
HVY54_21000	COG1113	amino acid transport
HVY54_21005	COG0545	Peptidyl-prolyl cis-trans isomerase
HVY54_21010	COG3061	Opacity-associated protein A
HVY54_21020	COG0675	Transposase, IS605 OrfB family
HVY54_21045	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HVY54_21080	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HVY54_21085	COG3414	Phosphotransferase system galactitol-specific IIB component
HVY54_21090	COG3037	sugar-specific permease SgaT UlaA
HVY54_21105	COG1073	alpha beta
HVY54_21110	COG3650	response to hydrogen peroxide
HVY54_21120	COG1960	acyl-CoA dehydrogenase activity
HVY54_21125	COG0754	glutathionylspermidine amidase activity
HVY54_21130	COG5463	Belongs to the UPF0441 family
HVY54_21135	COG3766	membrane
HVY54_21145	COG1842	Phage shock protein A
HVY54_21150	COG3789	protein conserved in bacteria
HVY54_21155	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HVY54_21160	COG0557	exoribonuclease II activity
HVY54_21175	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
HVY54_21180	COG0330	HflC and HflK could
HVY54_21185	COG0330	HflC and HflK could
HVY54_21190	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HVY54_21210	COG0860	N-Acetylmuramoyl-L-alanine amidase
HVY54_21215	COG0802	atpase or kinase
HVY54_21220	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HVY54_21220	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HVY54_21265	COG1511	domain protein
HVY54_21265	COG3264	Mechanosensitive ion channel
HVY54_21275	COG0531	amino acid
HVY54_21285	COG1053	succinate dehydrogenase
HVY54_21290	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HVY54_21305	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HVY54_21310	COG3040	lipid binding
HVY54_21315	COG2076	Multidrug Resistance protein
HVY54_21320	COG5510	response to toxic substance
HVY54_21325	COG5510	response to toxic substance
HVY54_21335	COG1509	lysine 2,3-aminomutase activity
HVY54_21360	COG0531	amino acid
HVY54_21365	COG3030	protein affecting phage T7 exclusion by the F plasmid
HVY54_21370	COG1027	Aspartate ammonia-lyase
HVY54_21375	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HVY54_21385	COG4232	protein-disulfide reductase activity
HVY54_21390	COG1309	transcriptional regulator
HVY54_21400	COG0582	viral genome integration into host DNA
HVY54_21410	COG1585	Membrane protein implicated in regulation of membrane protease activity
HVY54_21420	COG3539	Fimbrial protein
HVY54_21425	COG3121	Chaperone
HVY54_21450	COG0210	DNA helicase
HVY54_21455	COG1205	dead DEAH box helicase
HVY54_21455	COG1111	helicase
HVY54_21465	COG0553	Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair
HVY54_21475	COG3039	Transposase
HVY54_21530	COG2916	Histone family protein nucleoid-structuring protein H-NS
HVY54_21565	COG3596	GTP binding
HVY54_21590	COG2003	Belongs to the UPF0758 family
HVY54_21625	COG3710	Transcriptional regulator
HVY54_21630	COG0531	amino acid
HVY54_21635	COG1982	Orn Lys Arg decarboxylase major
HVY54_21640	COG3104	oligopeptide transport
HVY54_21645	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HVY54_21660	COG2388	GCN5-related N-acetyl-transferase
HVY54_21665	COG3592	Divergent 4Fe-4S mono-cluster
HVY54_21670	COG3290	protein histidine kinase activity
HVY54_21675	COG4565	transcriptional regulatory protein
HVY54_21680	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HVY54_21685	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HVY54_21685	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
HVY54_21690	COG3647	Membrane
HVY54_21695	COG2211	Major facilitator Superfamily
HVY54_21700	COG1486	melibiose metabolic process
HVY54_21705	COG2169	Transcriptional regulator
HVY54_21710	COG1982	Orn Lys Arg decarboxylase major
HVY54_21715	COG2207	Transcriptional regulator
HVY54_21720	COG0531	amino acid
HVY54_21725	COG2194	sulfuric ester hydrolase activity
HVY54_21730	COG0745	RESPONSE REGULATOR receiver
HVY54_21735	COG0642	Histidine kinase
HVY54_21745	COG0477	Major facilitator Superfamily
HVY54_21760	COG2824	Alkylphosphonate utilization operon protein PhnA
HVY54_21765	COG2764	glyoxalase bleomycin resistance protein dioxygenase
HVY54_21775	COG3221	ABC-type phosphate phosphonate transport system periplasmic component
HVY54_21780	COG3639	organic phosphonate transmembrane transporter activity
HVY54_21785	COG2188	Transcriptional regulator
HVY54_21790	COG3624	Phosphonate C-P lyase system protein PhnG
HVY54_21795	COG3625	alpha-D-ribose 1-methylphosphonate 5-triphosphate synthase activity
HVY54_21800	COG3626	phosphonate metabolism
HVY54_21805	COG3627	carbon phosphorus lyase activity
HVY54_21810	COG4107	phosphonate C-P lyase system protein PhnK
HVY54_21815	COG4778	phosphonate C-P lyase system protein PhnL
HVY54_21820	COG3454	Phosphonate metabolism
HVY54_21825	COG3709	Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP)
HVY54_21830	COG0456	acetyltransferase
HVY54_21835	COG1235	May be involved in the transport of PQQ or its precursor to the periplasm
HVY54_21850	COG1129	ABC transporter
HVY54_21855	COG1172	Belongs to the binding-protein-dependent transport system permease family
HVY54_21875	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HVY54_21885	COG2015	COG2015, Alkyl sulfatase and related hydrolases
HVY54_21895	COG1566	PFAM secretion protein HlyD family protein
HVY54_21900	COG1289	transmembrane transporter activity
HVY54_21915	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
HVY54_21920	COG1301	dicarboxylic acid transport
HVY54_21925	COG4235	cytochrome complex assembly
HVY54_21930	COG3088	subunit of a heme lyase
HVY54_21935	COG1138	Cytochrome C-type biogenesis protein
HVY54_21940	COG3301	Polysulphide reductase, NrfD
HVY54_21945	COG0437	4 iron, 4 sulfur cluster binding
HVY54_21950	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
HVY54_21960	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HVY54_21965	COG3162	membrane
HVY54_21975	COG1357	PFAM Pentapeptide repeats (8 copies)
HVY54_21980	COG0025	NhaP-type Na H and K H
HVY54_21985	COG2252	PERMEase
HVY54_21990	COG0789	Transcriptional regulator
HVY54_21995	COG2207	Transcriptional regulator
HVY54_22000	COG4943	cyclic-guanylate-specific phosphodiesterase activity
HVY54_22010	COG0629	single-stranded DNA binding
HVY54_22015	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HVY54_22020	COG2315	Protein conserved in bacteria
HVY54_22025	COG0432	Pfam Uncharacterised protein family UPF0047
HVY54_22030	COG3700	Belongs to the class B bacterial acid phosphatase family
HVY54_22040	COG1448	Aminotransferase
HVY54_22050	COG3201	nicotinamide mononucleotide transporter
HVY54_22055	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HVY54_22060	COG0305	Participates in initiation and elongation during chromosome replication
HVY54_22065	COG0604	alcohol dehydrogenase
HVY54_22075	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HVY54_22085	COG0735	belongs to the Fur family
HVY54_22090	COG3237	CsbD-like
HVY54_22095	COG0534	Mate efflux family protein
HVY54_22105	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HVY54_22140	COG3842	ATPase activity
HVY54_22145	COG2182	Extracellular solute-binding protein
HVY54_22150	COG1175	transmembrane transport
HVY54_22155	COG3833	ABC-type maltose transport systems, permease component
HVY54_22160	COG2814	Major facilitator Superfamily
HVY54_22160	COG0477	Major facilitator Superfamily
HVY54_22180	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HVY54_22205	COG0527	aspartate kinase activity
HVY54_22215	COG1187	pseudouridine synthase activity
HVY54_22260	COG1283	sodium-dependent phosphate transmembrane transporter activity
HVY54_22265	COG0646	methionine synthase
HVY54_22265	COG1410	methionine synthase
HVY54_22270	COG1414	Transcriptional regulator
HVY54_22285	COG2224	Isocitrate lyase
HVY54_22290	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
HVY54_22300	COG0456	acetyltransferase
HVY54_22330	COG0151	Belongs to the GarS family
HVY54_22335	COG2204	response regulator
HVY54_22340	COG4191	Histidine kinase
HVY54_22345	COG3678	ATP-independent chaperone mediated protein folding
HVY54_22360	COG3068	Protein conserved in bacteria
HVY54_22395	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HVY54_22400	COG2104	thiamine diphosphate biosynthetic process
HVY54_22410	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HVY54_22450	COG0250	Participates in transcription elongation, termination and antitermination
HVY54_22455	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HVY54_22490	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
HVY54_22490	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
HVY54_22525	COG0796	Provides the (R)-glutamate required for cell wall biosynthesis
HVY54_22530	COG4206	TonB-dependent receptor
HVY54_22535	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HVY54_22545	COG1309	transcriptional regulator
HVY54_22550	COG0477	Major facilitator Superfamily
HVY54_22555	COG1473	amidohydrolase
HVY54_22565	COG0583	DNA-binding transcription factor activity
HVY54_22580	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HVY54_22595	COG2194	sulfuric ester hydrolase activity
HVY54_22600	COG2207	Transcriptional regulator
HVY54_22605	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HVY54_22610	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HVY54_22615	COG1882	Formate acetyltransferase
HVY54_22620	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HVY54_22625	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HVY54_22630	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HVY54_22630	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HVY54_22630	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HVY54_22635	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HVY54_22640	COG0371	Dehydrogenase
HVY54_22645	COG3738	Protein conserved in bacteria
HVY54_22650	COG0697	spore germination
HVY54_22660	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HVY54_22670	COG0460	homoserine dehydrogenase
HVY54_22670	COG0527	aspartate kinase activity
HVY54_22675	COG0626	cystathionine gamma-synthase activity
HVY54_22685	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
HVY54_22710	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HVY54_22715	COG1609	Transcriptional regulator
HVY54_22720	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HVY54_22735	COG1575	Belongs to the MenA family. Type 1 subfamily
HVY54_22760	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HVY54_22770	COG1494	fructose-1,6-bisphosphatase
HVY54_22780	COG0589	response to stress
HVY54_22785	COG3691	Protein conserved in bacteria
HVY54_22790	COG3152	Membrane
HVY54_22810	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
HVY54_22825	COG3678	ATP-independent chaperone mediated protein folding
HVY54_22830	COG0745	RESPONSE REGULATOR receiver
HVY54_22835	COG2205	protein histidine kinase activity
HVY54_22840	COG2258	MOSC domain
HVY54_22850	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HVY54_22860	COG4977	sequence-specific DNA binding
HVY54_22860	COG1917	Cupin 2, conserved barrel domain protein
HVY54_22895	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HVY54_22900	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HVY54_22900	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HVY54_22905	COG1363	Peptidase, m42
HVY54_22910	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HVY54_22910	COG3711	transcriptional antiterminator
HVY54_22930	COG0437	4 iron, 4 sulfur cluster binding
HVY54_22935	COG2864	formate dehydrogenase
HVY54_22945	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HVY54_22950	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HVY54_22960	COG0456	acetyltransferase
HVY54_22975	COG1011	Hydrolase
HVY54_22980	COG1349	DNA-binding transcription factor activity
HVY54_22985	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HVY54_22990	COG2084	Dehydrogenase
HVY54_22995	COG3684	Belongs to the aldolase LacD family
HVY54_23000	COG2942	2-epimerase
HVY54_23005	COG2017	converts alpha-aldose to the beta-anomer
HVY54_23015	COG1501	Belongs to the glycosyl hydrolase 31 family
HVY54_23020	COG2211	Major facilitator Superfamily
HVY54_23025	COG2211	Major facilitator Superfamily
HVY54_23030	COG1452	involved in the assembly of lipopolysaccharide (LPS) at the surface of the outer membrane
HVY54_23035	COG2271	Major facilitator Superfamily
HVY54_23040	COG1082	Xylose isomerase domain protein TIM barrel
HVY54_23045	COG2188	Transcriptional regulator
HVY54_23055	COG0174	glutamine synthetase
HVY54_23060	COG3852	Histidine kinase
HVY54_23065	COG2204	response regulator
HVY54_23075	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HVY54_23080	COG3078	GTPase activator activity
HVY54_23090	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HVY54_23090	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HVY54_23095	COG0204	Acyl-transferase
HVY54_23100	COG5339	Protein conserved in bacteria
HVY54_23105	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HVY54_23110	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HVY54_23115	COG3084	Protein conserved in bacteria
HVY54_23120	COG0746	molybdenum cofactor guanylyltransferase activity
HVY54_23125	COG1763	Mo-molybdopterin cofactor biosynthetic process
HVY54_23150	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
HVY54_23155	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HVY54_23160	COG1739	Uncharacterized protein family UPF0029
HVY54_23180	COG0543	2 iron, 2 sulfur cluster binding
HVY54_23185	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HVY54_23190	COG0250	Participates in transcription elongation, termination and antitermination
HVY54_23195	COG0084	hydrolase, TatD family'
HVY54_23200	COG0805	protein transport
HVY54_23205	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HVY54_23210	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HVY54_23220	COG3165	ubiquinone biosynthetic process from chorismate
HVY54_23230	COG1322	Protein conserved in bacteria
HVY54_23235	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
HVY54_23240	COG0412	Dienelactone hydrolase
HVY54_23250	COG0583	DNA-binding transcription factor activity
HVY54_23255	COG0697	spore germination
HVY54_23260	COG0561	phosphatase activity
HVY54_23265	COG2267	carboxylic ester hydrolase activity
HVY54_23270	COG1280	lysine exporter protein (LysE YggA)
HVY54_23275	COG1280	lysine exporter protein (LysE YggA)
HVY54_23280	COG0514	ATP-dependent DNA helicase (RecQ)
HVY54_23285	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
HVY54_23290	COG2050	protein possibly involved in aromatic compounds catabolism
HVY54_23295	COG2962	Rard protein
HVY54_23310	COG0598	Magnesium transport protein CorA
HVY54_23315	COG3698	Phosphodiester glycosidase
HVY54_23320	COG1912	Pfam S-adenosyl-l-methionine hydroxide adenosyltransferase
HVY54_23325	COG0210	DNA helicase
HVY54_23330	COG1011	Hydrolase
HVY54_23340	COG3159	Protein conserved in bacteria
HVY54_23350	COG5567	small periplasmic lipoprotein
HVY54_23360	COG3072	Adenylate cyclase
HVY54_23370	COG1587	Uroporphyrinogen-III synthase
HVY54_23375	COG2959	enzyme of heme biosynthesis
HVY54_23380	COG3071	HemY protein
HVY54_23385	COG3119	arylsulfatase activity
HVY54_23390	COG0641	radical SAM
HVY54_23415	COG1113	amino acid transport
HVY54_23435	COG2244	polysaccharide biosynthetic process
HVY54_23440	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HVY54_23445	COG0456	acetyltransferase
HVY54_23450	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
HVY54_23455	COG1088	dTDP-glucose 4,6-dehydratase activity
HVY54_23460	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
HVY54_23465	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HVY54_23470	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
HVY54_23475	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HVY54_23480	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
HVY54_23490	COG3118	belongs to the thioredoxin family
HVY54_23505	COG0210	DNA helicase
HVY54_23510	COG3692	DNA binding
HVY54_23515	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HVY54_23525	COG0583	DNA-binding transcription factor activity
HVY54_23530	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HVY54_23540	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HVY54_23545	COG3978	acetolactate synthase activity
HVY54_23565	COG0606	chelatase, subunit chli
HVY54_23570	COG3085	chromosome segregation
HVY54_23610	COG2186	Transcriptional regulator
HVY54_23615	COG0477	Major facilitator Superfamily
HVY54_23620	COG1609	Transcriptional regulator
HVY54_23625	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HVY54_23630	COG1879	ABC-type sugar transport system periplasmic component
HVY54_23635	COG1172	Belongs to the binding-protein-dependent transport system permease family
HVY54_23640	COG1129	ABC transporter
HVY54_23670	COG1522	sequence-specific DNA binding
HVY54_23675	COG0716	FMN binding
HVY54_23690	COG3312	ion transport
HVY54_23740	COG0449	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
HVY54_23750	COG3121	Chaperone
HVY54_23765	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HVY54_23770	COG0573	inorganic phosphate transmembrane transporter activity
HVY54_23775	COG0581	inorganic phosphate transmembrane transporter activity
HVY54_23780	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HVY54_23785	COG0704	Plays a role in the regulation of phosphate uptake
HVY54_23810	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HVY54_23815	COG2252	PERMEase
HVY54_23820	COG0431	NADPH-dependent FMN reductase
HVY54_23825	COG2091	lysine biosynthetic process via aminoadipic acid
HVY54_23840	COG0814	amino acid
HVY54_23970	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HVY54_23985	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HVY54_24035	COG1053	succinate dehydrogenase
HVY54_24235	COG3451	type IV secretory pathway VirB4
HVY54_24295	COG0484	heat shock protein binding
HVY54_24320	COG2894	cell division
HVY54_24340	COG0697	spore germination
HVY54_24395	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HVY54_24425	COG3505	Type IV secretory pathway VirD4
HVY54_24430	COG0630	type IV secretory pathway, VirB11 components, and related ATPases involved in Archaeal flagella biosynthesis