locus-tag class description HVZ20_00010 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) HVZ20_00020 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HVZ20_00025 ENOG4105VP5 Bacterial protein of unknown function (DUF937) HVZ20_00030 ENOG410667J hydrolase HVZ20_00035 ENOG410657R replicase EC 2.7 HVZ20_00040 ENOG4105EMF GntR family transcriptional regulator HVZ20_00045 ENOG4105EI3 2-dehydro-3-deoxygalactonokinase EC 2.7.1.58 HVZ20_00050 ENOG4108RTU Aldolase HVZ20_00060 ENOG4105DJB Major Facilitator Superfamily HVZ20_00070 ENOG4105D99 atp gtp-binding protein HVZ20_00075 ENOG4105R2A (LipO)protein HVZ20_00095 ENOG4108AHD Transcriptional regulator HVZ20_00100 ENOG4107RUZ Sss sodium solute transporter superfamily HVZ20_00105 ENOG4105CBG Sulfatase HVZ20_00110 ENOG4105VG5 Membrane HVZ20_00115 ENOG4105JP4 Inner membrane protein yidG HVZ20_00120 ENOG4105J13 transcriptional regulator HVZ20_00125 ENOG4105E5M Multidrug resistance protein D HVZ20_00135 ENOG4105C7K acetolactate synthase HVZ20_00140 ENOG4105M71 acetolactate synthase 1 regulatory subunit HVZ20_00145 ENOG4108KX4 response regulator HVZ20_00150 ENOG4105BZU Histidine kinase HVZ20_00155 ENOG4105CXY transporter HVZ20_00160 ENOG4105CXY transporter HVZ20_00170 ENOG4105C7N Xanthine uracil vitamin C permease HVZ20_00175 ENOG4108SAJ Protein of unknown function (DUF1198) HVZ20_00185 ENOG4105T8A Uncharacterized protein YicS HVZ20_00190 ENOG4105D01 (LipO)protein HVZ20_00195 ENOG4108UZ3 Transporter HVZ20_00200 ENOG4105S8Q sugar efflux transporter HVZ20_00245 ENOG4108HHI Type III secretion system protein HVZ20_00250 ENOG41083GP type iii secretion HVZ20_00255 ENOG4108TN6 type iii secretion HVZ20_00260 ENOG4108IUF type iii secretion HVZ20_00320 ENOG4108JIR Flagellum-specific ATP synthase HVZ20_00375 ENOG4105UQF type iii secretion HVZ20_00425 ENOG4105CT4 transporter HVZ20_00430 ENOG4105CJQ hydrolase, family 31 HVZ20_00435 ENOG4105ETD TRANSCRIPTIONal HVZ20_00440 ENOG4105DM4 PTS System HVZ20_00445 ENOG4108YRF PTS System HVZ20_00450 ENOG4105DM4 PTS System HVZ20_00455 ENOG4105D2N Aldolase HVZ20_00465 ENOG4105DKQ ROK family HVZ20_00475 ENOG4105JV1 AsmA family HVZ20_00480 ENOG4105C2W permease HVZ20_00485 ENOG4105D6U Sodium Glutamate Symporter HVZ20_00490 ENOG4105CB5 ATP-dependent DNA helicase recG HVZ20_00495 ENOG4105FE8 tRNA (Guanosine-2'-O-)-methyltransferase HVZ20_00500 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) HVZ20_00510 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) HVZ20_00515 ENOG410649J Catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction (By similarity) HVZ20_00520 ENOG4105EN6 Membrane HVZ20_00530 ENOG4105DSJ YicC domain protein HVZ20_00555 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase HVZ20_00565 ENOG4105KDC 50s ribosomal protein l28 HVZ20_00585 ENOG4105D8A 3-Deoxy-D-manno-octulosonic-acid transferase HVZ20_00590 ENOG4105DKP glycosyl transferase, family 9 HVZ20_00595 ENOG4107RJ7 Glycosyl transferase (Group 1 HVZ20_00600 ENOG4107543 (lipo)polysaccharide HVZ20_00605 ENOG410650X lipopolysaccharide core region biosynthetic process HVZ20_00610 ENOG4107XU6 Glycosyl transferase (Group 1 HVZ20_00615 ENOG4106AH0 Glycosyl Transferase HVZ20_00620 ENOG4105X1N Glycosyl transferase family 8 HVZ20_00625 ENOG4108PDR lipopolysaccharide core biosynthesis protein HVZ20_00630 ENOG4108QD8 lipopolysaccharide core biosynthesis protein HVZ20_00635 ENOG4108XNZ glycosyl transferase HVZ20_00640 ENOG41068PG O-Antigen polymerase HVZ20_00645 ENOG4105D16 lipopolysaccharide heptosyltransferase i HVZ20_00650 ENOG4105XA0 heptosyltransferase ii HVZ20_00660 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) HVZ20_00670 ENOG4105K64 Glycosyl transferase, family 2 HVZ20_00675 ENOG4105PXI polysaccharide deacetylase HVZ20_00680 ENOG41063SB peptidase HVZ20_00690 ENOG4107YZP Rhodanese domain protein HVZ20_00695 ENOG4105VW4 glutaredoxin 3 HVZ20_00710 ENOG4105D7W serine acetyltransferase HVZ20_00715 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) HVZ20_00725 ENOG41073TP transcriptional regulator HVZ20_00730 ENOG4105DAA L-lactate HVZ20_00745 ENOG4108YYI Protein of unknown function (DUF2810) HVZ20_00750 ENOG41060ND LF82 chromosome, complete sequence HVZ20_00755 ENOG4105E61 Mannitol repressor protein HVZ20_00765 ENOG4105CTS PTS system mannitol-specific HVZ20_00770 ENOG4105FP6 Protein of unknown function (DUF3302) HVZ20_00775 ENOG4105EFX secretion protein, HlyD family HVZ20_00780 ENOG4108U78 Glutathione S-transferase HVZ20_00790 ENOG4105EM7 Selenocysteine-specific translation elongation factor HVZ20_00795 ENOG4105C0A alcohol dehydrogenase HVZ20_00805 ENOG4105C26 Dehydrogenase HVZ20_00810 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase HVZ20_00815 ENOG41064BZ L-xylulose 5-phosphate 3-epimerase HVZ20_00820 ENOG4105H6Q decarboxylase HVZ20_00825 ENOG4105CMG Carbohydrate kinase HVZ20_00830 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit HVZ20_00835 ENOG4105CG6 trap dicarboxylate transporter dctm subunit HVZ20_00840 ENOG4105XDZ Tripartite ATP-independent periplasmic transporter HVZ20_00845 ENOG4108M5W HVZ20_00850 ENOG4108R66 Conserved Protein HVZ20_00860 ENOG4105J4Q Transcriptional regulator HVZ20_00865 ENOG4108XIB electron transport protein ysaA HVZ20_00870 ENOG4105JKW Valine--pyruvate aminotransferase HVZ20_00875 ENOG4107T9C Alpha amylase catalytic region HVZ20_00880 ENOG4108UR8 BAX protein HVZ20_00885 ENOG4105T16 Transcriptional regulator (AraC family) HVZ20_00890 ENOG4108HWW ABC transporter HVZ20_00895 ENOG4105C2J ABC transporter HVZ20_00900 ENOG4105DFW ABC transporter HVZ20_00910 ENOG4105CMG Carbohydrate kinase HVZ20_00915 ENOG410688U Inner membrane protein yiaB HVZ20_00920 ENOG4108Z12 YiaAB two helix domain-containing protein HVZ20_00925 ENOG4105MEV Acyl-transferase HVZ20_00955 ENOG4105CH2 amidohydrolase HVZ20_00965 ENOG4105EJ2 Transcriptional regulator HVZ20_00970 ENOG4108Y73 Membrane HVZ20_00980 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) HVZ20_00985 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) HVZ20_01010 ENOG4105D4A Cell wall formation (By similarity) HVZ20_01015 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase HVZ20_01050 ENOG4105PM1 preprotein translocase subunit SecE HVZ20_01055 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) HVZ20_01090 ENOG4105D41 biosynthesis protein thiH HVZ20_01100 ENOG4105WHD thiamine biosynthesis protein ThiS HVZ20_01105 ENOG4105D06 uba thif-type nad fad binding protein HVZ20_01140 ENOG4105R2J Conserved Protein HVZ20_01150 ENOG4108T8B Protein of unknown function (DUF1481) HVZ20_01155 ENOG4105JBU Binds zinc. Could be an important component of the zinc- balancing mechanism HVZ20_01160 ENOG4105BZU Histidine kinase HVZ20_01165 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family HVZ20_01170 ENOG4105C12 Phosphoribosylglycinamide synthetase HVZ20_01205 ENOG41062WK cellular response to acidity HVZ20_01210 ENOG4105K5X acetyltransferase HVZ20_01220 ENOG4107QP3 malate synthase g HVZ20_01225 ENOG4108I9X Isocitrate lyase HVZ20_01235 ENOG41069M3 Transcriptional regulator HVZ20_01240 ENOG4105C3R Methionine synthase HVZ20_01250 ENOG4105EAM Na Pi-cotransporter HVZ20_01260 ENOG4105DXH Alcohol dehydrogenase zinc-binding domain protein HVZ20_01265 ENOG4105F3R pts system mannose fructose sorbose family iid HVZ20_01270 ENOG4105ETZ PTS System HVZ20_01275 ENOG4105KPI PTS system sorbose subfamily IIB component HVZ20_01280 ENOG4108XCU pts system HVZ20_01285 ENOG4105CHR reductase HVZ20_01290 ENOG4105DKT Transcriptional regulator HVZ20_01295 ENOG4105FE9 pseudouridine synthase HVZ20_01300 ENOG4108ZR5 Conserved Protein HVZ20_01305 ENOG4105CFH Aspartokinase HVZ20_01320 ENOG4108MDC (LipO)protein HVZ20_01325 ENOG4108Q9C Periplasmic Protein HVZ20_01330 ENOG4105E3R (LipO)protein HVZ20_01345 ENOG4105EG2 ABC transporter, permease HVZ20_01350 ENOG4105D56 permease protein HVZ20_01355 ENOG4107FKK extracellular solute-binding protein family 1 HVZ20_01360 ENOG4108IJ9 (ABC) transporter HVZ20_01370 ENOG4107W52 maltose operon periplasmic protein HVZ20_01375 ENOG4108RS6 transposase HVZ20_01395 ENOG41080IJ Diacylglycerol kinase HVZ20_01405 ENOG4107R73 Mate efflux family protein HVZ20_01410 ENOG4105VDW Csbd family HVZ20_01415 ENOG4105MYN Zinc uptake regulation protein HVZ20_01420 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) HVZ20_01425 ENOG4105P4Z Phage shock protein G HVZ20_01430 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein HVZ20_01435 ENOG4105CDU Replicative dna helicase HVZ20_01440 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) HVZ20_01445 ENOG4105CGF Aromatic amino acid aminotransferase HVZ20_01450 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 HVZ20_01455 ENOG4105C7S Dehydrogenase HVZ20_01460 ENOG4107QN2 dihydrolipoyl dehydrogenase HVZ20_01465 ENOG4105CMV Succinyl-CoA synthetase subunit beta HVZ20_01470 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha HVZ20_01475 ENOG4107QPK )-transporter HVZ20_01480 ENOG4105DG4 malate L-lactate dehydrogenase HVZ20_01485 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family HVZ20_01490 ENOG4105CQZ Histidine kinase HVZ20_01505 ENOG4105F0S class B acid phosphatase HVZ20_01510 ENOG4108YXI Secondary thiamine-phosphate synthase enzyme HVZ20_01515 ENOG4105MSB protein, conserved in bacteria HVZ20_01520 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) HVZ20_01525 ENOG4108UUM single-stranded DNA-binding protein HVZ20_01530 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter HVZ20_01535 ENOG4105ERH Fumarylacetoacetate hydrolase HVZ20_01540 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) HVZ20_01545 ENOG4105ETE Transcriptional regulator (LacI family HVZ20_01550 ENOG41079KZ Major Facilitator Superfamily HVZ20_01555 ENOG4105TW1 Carbohydrate-selective porin OprB HVZ20_01560 ENOG4105PMV Membrane HVZ20_01565 ENOG4108M8H domain protein HVZ20_01570 ENOG4108W3Q Transcriptional regulator HVZ20_01575 ENOG4108Z4X TRANSCRIPTIONal HVZ20_01580 ENOG4105C7N Xanthine uracil vitamin C permease HVZ20_01585 ENOG4105EEQ Na H antiporter HVZ20_01595 ENOG41062QD Membrane HVZ20_01600 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) HVZ20_01610 ENOG4105JJ8 Cytochrome c nitrite reductase, pentaheme subunit HVZ20_01615 ENOG4105D3S 4Fe-4S Ferredoxin, iron-sulfur binding domain protein HVZ20_01620 ENOG4105DVI reductase, NrfD HVZ20_01625 ENOG4108QKW cytochrome c-type biogenesis protein HVZ20_01635 ENOG4108W0S formate-dependent nitrite reductase complex HVZ20_01640 ENOG4105CK2 sodium dicarboxylate symporter HVZ20_01645 ENOG41082ND Uncharacterized protein yjcO HVZ20_01650 ENOG4108JQ7 (ABC) transporter HVZ20_01655 ENOG4105C3U ABC transporter HVZ20_01660 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HVZ20_01665 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HVZ20_01680 ENOG4105ETP RND efflux system, outer membrane lipoprotein HVZ20_01685 ENOG4108MI0 Resistance protein HVZ20_01690 ENOG4105J12 Multidrug resistance protein mdtN HVZ20_01705 ENOG4105EUZ Beta-lactamase domain protein HVZ20_01710 ENOG4107TFG D-allose kinase HVZ20_01715 ENOG4105UP7 3-epimerase HVZ20_01720 ENOG4105CNN ABC, transporter HVZ20_01725 ENOG4105C2J ABC transporter HVZ20_01730 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator HVZ20_01735 ENOG4105NYY transcriptional regulator, RpiR HVZ20_01740 ENOG4108YZG isomerase HVZ20_01750 ENOG4107SA6 carbon-phosphorus lyase complex accessory protein HVZ20_01755 ENOG410849A acetyltransferase, (GNAT) family HVZ20_01765 ENOG4105FD8 phosphonate metabolism protein PhnM HVZ20_01770 ENOG4105HRV phosphonate c-p lyase system protein phnl HVZ20_01775 ENOG4105ENV phosphonate C-P lyase system protein PhnK HVZ20_01780 ENOG4105FT8 Phosphonate metabolism HVZ20_01785 ENOG4105EKV Phosphonate metabolism protein HVZ20_01790 ENOG4105KZ6 phosphonate C-P lyase system protein PhnH HVZ20_01795 ENOG4105KQZ Phosphonate C-P lyase system protein PhnG HVZ20_01800 ENOG4107RJJ Transcriptional regulator HVZ20_01810 ENOG4105EHI Phosphonate ABC transporter, periplasmic HVZ20_01820 ENOG4108SQ4 Glyoxalase Bleomycin resistance protein (Dioxygenase HVZ20_01825 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA HVZ20_01835 ENOG4108YIV HVZ20_01840 ENOG4105CSH Transporter HVZ20_01850 ENOG4105ECM Sensor protein basS pmrB HVZ20_01855 ENOG4105XJC Two component transcriptional regulator (Winged helix family HVZ20_01860 ENOG4105DIJ Phosphoethanolamine transferase HVZ20_01870 ENOG4105D5Q Arginine ornithine antiporter HVZ20_01875 ENOG4106ZGR Transcriptional regulator HVZ20_01880 ENOG4105CXN decarboxylase HVZ20_01885 ENOG4108K2B transcriptional regulator HVZ20_01890 ENOG4105F8D glycoside hydrolase family 4 HVZ20_01895 ENOG4108R5S membrane HVZ20_01900 ENOG4107GFK fumarate HVZ20_01905 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter HVZ20_01910 ENOG4108MRH transcriptional regulatory protein HVZ20_01915 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism HVZ20_01920 ENOG4105VR1 Pfam:DUF1271 HVZ20_01925 ENOG410830R acetyltransferase HVZ20_01940 ENOG4105CRK lysyL-tRNA synthetase HVZ20_01945 ENOG4105DUX Transporter HVZ20_01950 ENOG4105CXN decarboxylase HVZ20_01965 ENOG4108SIC Transcriptional regulator HVZ20_01970 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) HVZ20_01980 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter HVZ20_01985 ENOG4108IJ0 Aspartate ammonia-lyase HVZ20_01990 ENOG4108YH1 overproduction of this protein in Escherichia coli inhibits the F plasmid-mediated exclusion of bacteriophage T7 HVZ20_01995 ENOG4105DVH amino acid HVZ20_02010 ENOG4108ZVF (LipO)protein HVZ20_02015 ENOG4105MTB Uncharacterized protein YjeJ HVZ20_02020 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein HVZ20_02030 ENOG4107PEH Entericidin EcnA/B family HVZ20_02035 ENOG4106BSU Entericidin B HVZ20_02040 ENOG4105KPY Small multidrug resistance protein HVZ20_02045 ENOG4105QNF Outer membrane lipoprotein HVZ20_02050 ENOG41066YJ Beta-lactamase HVZ20_02065 ENOG4105E33 succinate dehydrogenase HVZ20_02070 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) HVZ20_02080 ENOG4107SC7 Inner membrane transporter yjeM HVZ20_02085 ENOG4105EGS Mechanosensitive ion channel HVZ20_02130 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) HVZ20_02135 ENOG4105K8N protein family UPF0079, ATPase HVZ20_02140 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase HVZ20_02160 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) HVZ20_02165 ENOG4107QJR hflk protein HVZ20_02170 ENOG4105EPW hflc protein HVZ20_02190 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) HVZ20_02195 ENOG4105C2N RNA methyltransferase TrmH family group 3 HVZ20_02200 ENOG4105FUX Conserved Protein HVZ20_02205 ENOG4108P9J Phage shock protein A HVZ20_02210 ENOG4107VNS Protein of unknown function (DUF2491) HVZ20_02215 ENOG4105Z6B inner membrane protein yjfl HVZ20_02220 ENOG4108KXT Conserved Protein HVZ20_02225 ENOG4106032 Glutathionylspermidine synthase HVZ20_02230 ENOG4105CSU acyl-Coa dehydrogenase HVZ20_02235 ENOG4105S17 UPF0379 protein yjfN HVZ20_02240 ENOG4105WSB biofilm stress and motility protein A HVZ20_02245 ENOG4108MXZ Esterase HVZ20_02260 ENOG4105CZC PTS system ascorbate-specific transporter subunit IIC HVZ20_02265 ENOG410907W The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in ascorbate transport HVZ20_02275 ENOG4105H6Q decarboxylase HVZ20_02290 ENOG4105KIT UPF0379 protein yjfY HVZ20_02305 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) HVZ20_02325 ENOG4105DPW Major facilitator superfamily MFS_1 HVZ20_02330 ENOG4107S3R L-aspartate oxidase HVZ20_02335 ENOG4107R0K CoA transferase having broad substrate specificity for short-chain acyl-CoA thioesters with the activity decreasing when the length of the carboxylic acid chain exceeds four carbons (By similarity) HVZ20_02340 ENOG4105E39 Enoyl-CoA hydratase HVZ20_02350 ENOG4105CHR reductase HVZ20_02360 ENOG4105FHY Opacity-associated protein A HVZ20_02365 ENOG4108V1T peptidylprolyl cis-trans isomerase HVZ20_02385 ENOG4105DXC membrane HVZ20_02390 ENOG4105ECR NmrA family HVZ20_02395 ENOG4105KVH Transcriptional regulator HVZ20_02400 ENOG4107RNS bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase 3'-nucleotidase periplasmic HVZ20_02405 ENOG4108RNI 3'(2')5'-bisphosphate nucleotidase HVZ20_02410 ENOG4108UUE Transcriptional regulator HVZ20_02415 ENOG41061GZ Protein of unknown function (DUF1107) HVZ20_02420 ENOG4105C37 (CBS) domain HVZ20_02430 ENOG4105CFU surface antigen HVZ20_02435 ENOG4105MA0 exported protein HVZ20_02440 ENOG4108ZHD aig2 family HVZ20_02445 ENOG4105F0N pyrophosphate phospho-hydrolase HVZ20_02450 ENOG4107R5U Periplasmic binding protein LacI transcriptional regulator HVZ20_02460 ENOG4107R9N ABC transporter HVZ20_02465 ENOG41062B0 ABC transporter, permease HVZ20_02475 ENOG4105DFU Cell wall formation (By similarity) HVZ20_02495 ENOG4105NBR Pectinesterase HVZ20_02500 ENOG4108I1J Integrase HVZ20_02525 ENOG4105CMS peptidase U62, modulator of DNA gyrase HVZ20_02530 ENOG4108XVM Cytochrome b(562) HVZ20_02535 ENOG4108RDD Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine (By similarity) HVZ20_02540 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase HVZ20_02545 ENOG4105CG3 alpha amylase, catalytic region HVZ20_02550 ENOG4105C5Y PTS System HVZ20_02555 ENOG4105D4X repressor HVZ20_02565 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic HVZ20_02570 ENOG4105KME endoribonuclease L-psp HVZ20_02585 ENOG4107C93 pyrBI operon leader peptide HVZ20_02590 ENOG4108UQ8 endoribonuclease L-psp HVZ20_02595 ENOG4105F6U Short-chain dehydrogenase reductase Sdr HVZ20_02600 ENOG4108XFH Transcriptional regulator HVZ20_02605 ENOG4105XEP YhcH YjgK YiaL family protein HVZ20_02625 ENOG4105DBV ornithine carbamoyltransferase HVZ20_02630 ENOG4105KQT Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome (By similarity) HVZ20_02635 ENOG4108MJ3 acetyltransferase HVZ20_02640 ENOG4108M3P Membrane HVZ20_02645 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) HVZ20_02650 ENOG4105MYG DNA polymerase iii, chi subunit HVZ20_02660 ENOG4108M8S permease YjgP YjgQ family protein HVZ20_02665 ENOG4108K5H permease YjgP YjgQ family protein HVZ20_02670 ENOG4105D7A ATP-binding protein HVZ20_02785 ENOG4105FBQ ATPase associated with various cellular activities aaa_5 HVZ20_02815 ENOG4108MX5 Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses (By similarity) HVZ20_02820 ENOG41069FU Outer membrane channel protein allowing the entry of N- acetylneuraminic acid (Neu5Ac, the most abundant sialic acid on host cell surfaces) into the bacteria HVZ20_02825 ENOG4108W9T type 1 fimbriae regulatory protein HVZ20_02845 ENOG4108RQP Major type 1 subunit fimbrin HVZ20_02850 ENOG4108S54 Fimbrial protein HVZ20_02855 ENOG4108NAE Fimbrial chaperone protein HVZ20_02860 ENOG4105CW0 outer membrane usher protein HVZ20_02865 ENOG4108SQA Fimbrial HVZ20_02870 ENOG4108T65 Fimbrial HVZ20_02875 ENOG410643X FIMH SUBUNIT MANNOSE-sensitive type 1 fimbrial adhesin HVZ20_02890 ENOG4105DEI Mannitol dehydrogenase HVZ20_02895 ENOG4105C6F GntR Family Transcriptional Regulator HVZ20_02910 ENOG4107YNJ LysR family Transcriptional regulator HVZ20_02915 ENOG4105DYB Isoaspartyl dipeptidase HVZ20_02920 ENOG4108P2H Inner membrane protein YjiG HVZ20_02925 ENOG41074DU domain protein HVZ20_02935 ENOG4105CBP Major Facilitator HVZ20_02955 ENOG4105DCU 2-hydroxyglutaryl-CoA dehydratase HVZ20_02960 ENOG4106BRA Membrane HVZ20_02970 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HVZ20_02995 ENOG4105C4R Atp-dependent dna helicase HVZ20_03000 ENOG4105CKI cobalamin synthesis protein HVZ20_03005 ENOG4105VCD cytoplasmic protein HVZ20_03010 ENOG4105D22 carbon starvation protein HVZ20_03015 ENOG4105C8Q Methyl-accepting chemotaxis HVZ20_03020 ENOG4105CG6 trap dicarboxylate transporter dctm subunit HVZ20_03030 ENOG4108ERU trap dicarboxylate transporter subunit DctP HVZ20_03035 ENOG4105EEQ Na H antiporter HVZ20_03040 ENOG410617M Transcriptional regulator HVZ20_03045 ENOG4105CPQ Dehydrogenase HVZ20_03050 ENOG4107RES phosphoglycerol transferase I HVZ20_03055 ENOG4105RI1 glycoprotein receptor HVZ20_03060 ENOG4106CVF DNA replication protein HVZ20_03075 ENOG4105DWK Membrane HVZ20_03080 ENOG4108N8T regulatoR HVZ20_03085 ENOG4108T94 DNA-binding transcriptional activator BglJ HVZ20_03090 ENOG4108819 ferric iron reductase HVZ20_03095 ENOG4105YBH Protein of unknown function (DUF1435) HVZ20_03115 ENOG4108WPU DNA polymerase III subunit psi HVZ20_03120 ENOG4105KEG ribosomal-protein-alanine acetyltransferase HVZ20_03125 ENOG4105PAD Hydrolase HVZ20_03135 ENOG4105K3G Periplasmic Protein HVZ20_03145 ENOG4108NRW Phospholipase, patatin family HVZ20_03150 ENOG4105EYA deoxyribonuclease HVZ20_03155 ENOG41076CZ activating enzyme HVZ20_03160 ENOG4105G0K glycine radical enzyme YjjI family HVZ20_03165 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) HVZ20_03180 ENOG4105D3A purine nucleoside phosphorylase DeoD-type HVZ20_03195 ENOG41062Z9 Membrane HVZ20_03200 ENOG4105EAC phosphoserine phosphatase HVZ20_03205 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) HVZ20_03210 ENOG4107VZS Nicotinamide-nucleotide adenylyltransferase HVZ20_03215 ENOG4105W2W Cytotoxic translational repressor of toxin-antitoxin stability system HVZ20_03225 ENOG4105C5H ABC transporter HVZ20_03230 ENOG4107SC1 transglycosylase HVZ20_03250 ENOG4105UEI Transcriptional Regulator AraC Family HVZ20_03255 ENOG4108RH0 Crea protein HVZ20_03260 ENOG4105E3W Two component transcriptional regulator (Winged helix family HVZ20_03265 ENOG4105EB3 Histidine kinase HVZ20_03270 ENOG4105CT7 inner membrane cred family protein HVZ20_03275 ENOG41065U4 response regulator HVZ20_03280 ENOG410759A HVZ20_03285 ENOG4106FVC RNA methyltransferase HVZ20_03295 ENOG4105CFH Aspartokinase HVZ20_03305 ENOG4105D98 threonine synthase HVZ20_03310 ENOG41062C6 Protein of unknown function (DUF2502) HVZ20_03320 ENOG4105BZG amino acid carrier protein HVZ20_03330 ENOG4108RIR Molybdenum cofactor biosynthesis protein HVZ20_03340 ENOG4106HK8 GPR1 FUN34 yaaH family protein HVZ20_03345 ENOG4108QUJ UPF0174 protein YaaW HVZ20_03365 ENOG4108SER Transposase HVZ20_03370 ENOG4105WI6 cell killing protein encoded within cryptic prophage HVZ20_03380 ENOG41061MV Arylsulfatase HVZ20_03395 ENOG41063Z6 transcriptional regulator, lysR family HVZ20_03405 ENOG410647N response to DNA damage stimulus HVZ20_03410 ENOG4105DTN riboflavin biosynthesis protein ribF HVZ20_03425 ENOG41090X3 Peptidyl-prolyl cis-trans isomerase HVZ20_03445 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain HVZ20_03450 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain HVZ20_03455 ENOG4108XNW Transcriptional activatory protein CaiF HVZ20_03465 ENOG4106YT9 Enoyl-CoA hydratase HVZ20_03470 ENOG4105CEY Amp-dependent synthetase and ligase HVZ20_03495 ENOG4105C10 Electron transfer flavoprotein HVZ20_03500 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase HVZ20_03505 ENOG4105IBM Could be part of an electron transfer system required for anaerobic carnitine reduction. Could be a 3Fe-4S cluster- containing protein HVZ20_03510 ENOG4105C54 Major Facilitator superfamily HVZ20_03525 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) HVZ20_03555 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) HVZ20_03560 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) HVZ20_03565 ENOG4105E7H involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity) HVZ20_03570 ENOG41066UG Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host (By similarity) HVZ20_03575 ENOG4105D3G Pseudouridine synthase HVZ20_03585 ENOG4105CQ2 DNA polymerase HVZ20_03590 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase HVZ20_03605 ENOG41063TF transcriptional regulator (AraC HVZ20_03610 ENOG4108KF1 Membrane HVZ20_03620 ENOG4106SMU thiamine transporter membrane protein HVZ20_03625 ENOG4105DP9 ABC transporter HVZ20_03665 ENOG41064T2 transcriptional regulator, lysR family HVZ20_03675 ENOG4105C7K acetolactate synthase HVZ20_03680 ENOG4108ZP8 Acetolactate synthase small subunit HVZ20_03690 ENOG4107B7Y DNA-binding transcriptional regulator FruR HVZ20_03705 ENOG41063Y6 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) HVZ20_03710 ENOG4105CJN penicillin-binding protein HVZ20_03715 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) HVZ20_03720 ENOG4108EQQ Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity) HVZ20_03730 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) HVZ20_03735 ENOG4105CNI cell division protein FtsW HVZ20_03750 ENOG4105CPF Cell wall formation (By similarity) HVZ20_03755 ENOG4105K7E Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity) HVZ20_03760 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) HVZ20_03765 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) HVZ20_03785 ENOG4105M6F mutator MutT protein HVZ20_03800 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) HVZ20_03810 ENOG4105D7Q type ii secretion system HVZ20_03815 ENOG4107QHF type ii secretion system protein e HVZ20_03820 ENOG4108ZUW Major pilin subunit HVZ20_03825 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase HVZ20_03830 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase HVZ20_03835 ENOG4106A72 regulatory protein AmpE HVZ20_03840 ENOG4105C85 amino acid HVZ20_03845 ENOG41073TP transcriptional regulator HVZ20_03850 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) HVZ20_03855 ENOG4107QSN dihydrolipoamide acetyltransferase HVZ20_03860 ENOG4107QN2 dihydrolipoyl dehydrogenase HVZ20_03865 ENOG4108NST exported protein HVZ20_03870 ENOG4107QIJ Aconitate hydratase 2 HVZ20_03890 ENOG4108ZRK uncharacterized protein yacC HVZ20_03895 ENOG4105E3B Multicopper oxidase HVZ20_03900 ENOG4105DZG Dehydrogenase HVZ20_03905 ENOG4108UGV hypoxanthine phosphoribosyltransferase HVZ20_03910 ENOG41077A9 carbonic anhydrase HVZ20_03915 ENOG4105DA5 (ABC) transporter HVZ20_03920 ENOG4105E3A (ABC) transporter HVZ20_03925 ENOG4108YTN IIa component HVZ20_03930 ENOG4107BJW polysaccharide deacetylase HVZ20_03940 ENOG4108A32 Transposase HVZ20_03955 ENOG4105P0Q fimbrial-like protein YadC HVZ20_03960 ENOG4105SN2 fimbrial-like adhesin protein HVZ20_03990 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase HVZ20_03995 ENOG4105DJ0 Poly(A) Polymerase HVZ20_04000 ENOG4106F3G Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity) HVZ20_04015 ENOG4107XID 2'-5' rna ligase HVZ20_04020 ENOG4105CQ7 ATP-dependent helicase HVZ20_04025 ENOG4105BZ4 penicillin-binding protein HVZ20_04035 ENOG4108VCD Chaperone HVZ20_04040 ENOG4105CW0 outer membrane usher protein HVZ20_04050 ENOG4105E0K tonB-dependent siderophore receptor HVZ20_04055 ENOG4105E0A ABC, transporter HVZ20_04060 ENOG4105J76 Periplasmic binding protein HVZ20_04065 ENOG4105S6R Iron-hydroxamate transporter permease subunit HVZ20_04090 ENOG4105EN6 Membrane HVZ20_04095 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) HVZ20_04110 ENOG4105C0H protease HVZ20_04115 ENOG4108IXP Carbohydrate diacid transcriptional activator CdaR HVZ20_04130 ENOG4105E1P Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity) HVZ20_04135 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) HVZ20_04160 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) HVZ20_04165 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) HVZ20_04170 ENOG4105KNE Phosphatidate cytidylyltransferase HVZ20_04175 ENOG4105DZP Membrane-associated zinc metalloprotease HVZ20_04185 ENOG4108RFI Molecular chaperone that interacts specifically with outer membrane proteins, thus maintaining the solubility of early folding intermediates during passage through the periplasm (By similarity) HVZ20_04190 ENOG4105D7M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) HVZ20_04215 ENOG4105C0B DNA polymerase III (alpha subunit) HVZ20_04225 ENOG4105CXN decarboxylase HVZ20_04230 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase HVZ20_04235 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) HVZ20_04240 ENOG4105M1T rho-binding antiterminator HVZ20_04250 ENOG4108VWS Yaeq family HVZ20_04255 ENOG4108YZN class I peptide chain release factor HVZ20_04260 ENOG4107EII Lipoprotein involved with copper homeostasis and adhesion HVZ20_04265 ENOG4108UY0 (LipO)protein HVZ20_04275 ENOG4108R96 Methyltransferase, YaeB family HVZ20_04280 ENOG4108R8X outer membrane lipoprotein HVZ20_04285 ENOG4105D01 (LipO)protein HVZ20_04290 ENOG4108UMI ABC transporter, permease HVZ20_04295 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) HVZ20_04300 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase HVZ20_04340 ENOG4105HEI LysR family (Transcriptional regulator HVZ20_04350 ENOG4105F2W methyltransferase HVZ20_04355 ENOG4105E9H Lytic Murein transglycosylase HVZ20_04365 ENOG4105D1A Methyltransferase HVZ20_04375 ENOG4107RZZ dna polymerase iii epsilon subunit HVZ20_04385 ENOG4105CZ7 nitrilase cyanide hydratase and apolipoprotein n-acyltransferase HVZ20_04390 ENOG4108WN0 inhibitor of vertebrate lysozyme HVZ20_04395 ENOG4108RS6 transposase HVZ20_04400 ENOG4105VNT transposase (IS4 family) protein HVZ20_04405 ENOG4107QPN acyl-Coa dehydrogenase HVZ20_04415 ENOG4105E7A Glutamine amidotransferase HVZ20_04420 ENOG4105F7V ErfK ybiS ycfS ynhG family protein HVZ20_04425 ENOG4108YS0 lipoprotein YafL HVZ20_04450 ENOG4105D19 Role in flagellar biosynthesis (By similarity) HVZ20_04455 ENOG4105VS8 Flagellar biosynthetic protein fliq HVZ20_04460 ENOG4105CN7 Flagellar biosynthetic protein FliP HVZ20_04465 ENOG4105DD5 Flagellar motor switch protein HVZ20_04485 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) HVZ20_04490 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) HVZ20_04510 ENOG4107ZIC Glycerol-3-phosphate cytidylyltransferase HVZ20_04550 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) HVZ20_04555 ENOG4108ZC9 flagellar basal-body rod protein flgc HVZ20_04565 ENOG4105BZE flagellar hook protein, FlgE HVZ20_04570 ENOG4108KPB Flagellar basal-body rod protein FlgF HVZ20_04575 ENOG4105CGA flagellar basal-body rod protein FlgG HVZ20_04590 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj HVZ20_04600 ENOG4105DTJ flagellar hook-associated protein HVZ20_04615 ENOG4105I03 Flagellin HVZ20_04620 ENOG410804A Flagellar hook-associated 2 domain-containing protein HVZ20_04650 ENOG4107RD7 Flagellar Motor Protein, MotA HVZ20_04665 ENOG4108HYG acetyltransferase HVZ20_04675 ENOG4108S2Y peptide Chain Release factor HVZ20_04680 ENOG4105CIN aminoacyl-histidine dipeptidase HVZ20_04690 ENOG4105V1F Fermentation respiration switch protein HVZ20_04700 ENOG4105FCK Membrane HVZ20_04790 ENOG4105DFP Integrase HVZ20_04905 ENOG4105R3P Inner membrane protein yagU HVZ20_04910 ENOG4105PI0 Ferredoxin HVZ20_04925 ENOG4106PYX Receptor HVZ20_04985 ENOG4105EQ2 LysR family Transcriptional regulator HVZ20_04990 ENOG4107SET aldo keto reductase HVZ20_05010 ENOG4105CV8 reductase HVZ20_05015 ENOG4108KBJ Inner membrane protein YkgB HVZ20_05020 ENOG41066GK UPF0379 protein ykgI HVZ20_05040 ENOG4108K01 transcriptional regulator HVZ20_05050 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) HVZ20_05055 ENOG4107QR9 Iron-sulfur cluster binding protein HVZ20_05060 ENOG4108ZZK Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source (By similarity) HVZ20_05085 ENOG4105C94 Transporter HVZ20_05090 ENOG4105BZU Histidine kinase HVZ20_05095 ENOG4108NUU Transcriptional regulator HVZ20_05105 ENOG4105SZ2 membrAne HVZ20_05110 ENOG4107SNB ankyrin repeat protein YahD HVZ20_05125 ENOG4107R1Q Membrane protein FdrA HVZ20_05130 ENOG4107REC cytoplasmic protein HVZ20_05160 ENOG4105C5B carbamate kinase HVZ20_05165 ENOG4105DZC cytosine deaminase HVZ20_05175 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator HVZ20_05180 ENOG4105C2J ABC transporter HVZ20_05185 ENOG4105CNN ABC, transporter HVZ20_05190 ENOG4105CNN ABC, transporter HVZ20_05195 ENOG4105DQ4 alcohol dehydrogenase HVZ20_05205 ENOG4105E82 cytochrome subunit of dehydrogenase HVZ20_05215 ENOG4105TDT uncharacterized protein yahO HVZ20_05220 ENOG4108JU7 Transcriptional regulator HVZ20_05225 ENOG4105CR4 methylisocitrate lyase HVZ20_05230 ENOG4105BZN citrate synthase HVZ20_05235 ENOG4105DXD 2-methylcitrate dehydratase HVZ20_05240 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) HVZ20_05245 ENOG4105DQW permease for cytosine purines, uracil, thiamine, allantoin HVZ20_05250 ENOG4105DZC cytosine deaminase HVZ20_05255 ENOG4108UW5 maltose o-acetyltransferase HVZ20_05260 ENOG4105U0F oligosaccharide H symporter, major facilitator superfamily (MFS) HVZ20_05265 ENOG4105CNT hydrolase family 2 HVZ20_05270 ENOG4105ETE Transcriptional regulator (LacI family HVZ20_05280 ENOG4105IUQ nucleoprotein polynucleotide-associated enzyme HVZ20_05300 ENOG4106FTQ Taurine ABC transporter, periplasmic HVZ20_05305 ENOG4108IY8 ABC, transporter HVZ20_05310 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component HVZ20_05315 ENOG4105E2B Taurine dioxygenase HVZ20_05320 ENOG4105D52 delta-aminolevulinic acid dehydratase HVZ20_05330 ENOG4108PNB DNA-binding transcriptional regulator HVZ20_05335 ENOG4107R6D beta-lactam binding protein AmpH HVZ20_05340 ENOG4108DQG in Escherichia coli SbmA is involved in uptake of microcin J25 HVZ20_05345 ENOG4107QS8 (LipO)protein HVZ20_05350 ENOG4105FR5 inner membrane protein YaiY HVZ20_05355 ENOG4105UNH Membrane HVZ20_05360 ENOG4105CPF Cell wall formation (By similarity) HVZ20_05375 ENOG4105G6Z alkaline phosphatase HVZ20_05380 ENOG4105VIF phosphate starvation-inducible protein HVZ20_05385 ENOG4105BZU Histidine kinase HVZ20_05390 ENOG4105II7 pyrroline-5-carboxylate reductase HVZ20_05405 ENOG4105SS3 HVZ20_05410 ENOG4105HBA AroM protein HVZ20_05435 ENOG4105DKQ ROK family HVZ20_05440 ENOG4105F27 Major Facilitator HVZ20_05445 ENOG4105EYH Exonuclease HVZ20_05450 ENOG4107RH8 nuclease SbcCD subunit D HVZ20_05455 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HVZ20_05460 ENOG4105BZU Histidine kinase HVZ20_05465 ENOG4105CWM branched-chain amino acid transport system II carrier protein HVZ20_05470 ENOG4105C85 amino acid HVZ20_05475 ENOG4107R28 alpha amylase, catalytic region HVZ20_05485 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) HVZ20_05495 ENOG4105VIE preprotein translocase, subunit YajC HVZ20_05500 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) HVZ20_05505 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) HVZ20_05510 ENOG4105X54 addiction module antidote protein HVZ20_05520 ENOG4105N1F Hnh endonuclease HVZ20_05525 ENOG4105DRB nucleoside-specific channel-forming protein HVZ20_05530 ENOG4108KIC (LipO)protein HVZ20_05540 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) HVZ20_05545 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) HVZ20_05555 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) HVZ20_05560 ENOG4108ZAI phosphatidylglycerophosphatase a HVZ20_05565 ENOG4105CPC Aldo Keto reductase HVZ20_05575 ENOG4105CTB Polyprenyl synthetase HVZ20_05590 ENOG4107S0N DJ-1 family HVZ20_05595 ENOG4108JZF Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) HVZ20_05605 ENOG4107RDB Major Facilitator HVZ20_05615 ENOG41090KH cytochrome o ubiquinol oxidase (subunit iv) HVZ20_05620 ENOG4105CCU oxidase (Subunit III) HVZ20_05625 ENOG4105BZ9 Cytochrome C oxidase, subunit I HVZ20_05630 ENOG4105E2S oxidase) subunit II HVZ20_05635 ENOG4105EYM Major Facilitator superfamily HVZ20_05640 ENOG4105IEY (LipO)protein HVZ20_05645 ENOG4105M85 Bola protein HVZ20_05665 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) HVZ20_05670 ENOG4105K70 DNA-binding protein HVZ20_05675 ENOG4105EIN peptidylprolyl cis-trans isomerase HVZ20_05680 ENOG41083P1 competence protein ComEA helix-hairpin-helix repeat protein HVZ20_05685 ENOG4108TGP Thioesterase superfamily protein HVZ20_05695 ENOG4108NFA extracellular solute-binding protein HVZ20_05705 ENOG4108XM1 transcriptional regulator AsnC family HVZ20_05710 ENOG4105BZ1 (ABC) transporter HVZ20_05715 ENOG4105BZ1 (ABC) transporter HVZ20_05720 ENOG4108YZA Nitrogen regulatory protein pii HVZ20_05725 ENOG4105BZU Histidine kinase HVZ20_05730 ENOG4105C29 acyl-CoA thioesterase HVZ20_05735 ENOG4108MNP Glycoprotein polysaccharide metabolism HVZ20_05740 ENOG41080UX Methyltransferase HVZ20_05750 ENOG4105KCV RNA signal recognition particle 4.5S RNA HVZ20_05755 ENOG41066DG (EAL) domain protein HVZ20_05760 ENOG4105GSJ Inner membrane protein ylaC HVZ20_05765 ENOG4108UW5 maltose o-acetyltransferase HVZ20_05770 ENOG4105KF5 hemolysin expression-modulating protein HVZ20_05775 ENOG4108UKR Biofilm formation regulator YbaJ HVZ20_05780 ENOG4105BZS acriflavin resistance protein HVZ20_05785 ENOG4105C1P efflux transporter, rnd family, mfp subunit HVZ20_05790 ENOG4107XI7 Tetr family transcriptional regulator HVZ20_05795 ENOG4105EGS Mechanosensitive ion channel HVZ20_05800 ENOG4106428 Protein of unknown function (DUF2496) HVZ20_05805 ENOG4108URS primosomal replication protein n'' HVZ20_05810 ENOG4105WD1 Membrane HVZ20_05820 ENOG4107QMP dna polymerase iii subunits gamma and tau HVZ20_05850 ENOG4105F2M alpha beta hydrolase fold-3 domain protein HVZ20_05855 ENOG4107RE1 Inosine-guanosine kinase HVZ20_05860 ENOG4105CKD glutathione-regulated potassium-efflux system protein HVZ20_05865 ENOG4105EU0 Major facilitator Superfamily HVZ20_05870 ENOG4105CGH 5'-nucleotidase HVZ20_05875 ENOG4108Z66 YbaK ebsC protein HVZ20_05880 ENOG4105MBR gumn family HVZ20_05885 ENOG4105C59 p-type ATPase HVZ20_05890 ENOG4105CSV Glutaminase HVZ20_05895 ENOG4107RY6 amino acid HVZ20_05925 ENOG4105G5H Membrane HVZ20_05930 ENOG4107QX8 SPFH domain, Band 7 family protein HVZ20_05935 ENOG41083J0 (ABC) transporter HVZ20_05940 ENOG4105C4B ABC transporter, permease HVZ20_05945 ENOG4107QR8 Thioredoxin HVZ20_05950 ENOG4105E1F short-chain dehydrogenase reductase HVZ20_05955 ENOG4108UJV acyl-CoA thioesterase i HVZ20_05960 ENOG4108I0Y (ABC) transporter HVZ20_05965 ENOG4105CV6 ABC transporter, permease HVZ20_05975 ENOG4107653 Transcriptional regulator HVZ20_05980 ENOG4108Z2U ureidoglycolate hydrolase HVZ20_05985 ENOG4108N16 Negative regulator of allantoin and glyoxylate utilization operons. Binds to the gcl promoter and to the allS- allA intergenic region HVZ20_05990 ENOG41060W2 glyoxylate carboligase HVZ20_05995 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) HVZ20_06000 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase HVZ20_06005 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease HVZ20_06015 ENOG4105DTE Xanthine uracil vitamin C permease HVZ20_06020 ENOG4105BZW Glycerate kinase HVZ20_06025 ENOG4105S0E allantoin catabolism protein HVZ20_06030 ENOG4105CE7 Amidase, hydantoinase carbamoylase family HVZ20_06035 ENOG4105DG4 malate L-lactate dehydrogenase HVZ20_06040 ENOG4107R1Q Membrane protein FdrA HVZ20_06045 ENOG4107REC cytoplasmic protein HVZ20_06050 ENOG4105G5A Protein of unknown function (DUF2877) HVZ20_06055 ENOG4105C5B carbamate kinase HVZ20_06060 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit HVZ20_06065 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) HVZ20_06075 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) HVZ20_06085 ENOG4105S2T inner membrane protein YbcI HVZ20_06105 ENOG4105WQ3 Rna-binding protein HVZ20_06125 ENOG4105UZW Tail fiber assembly protein HVZ20_06130 ENOG4108WF3 methyltransferase HVZ20_06135 ENOG4108NC2 Outer membrane protease HVZ20_06140 ENOG4105QUW HVZ20_06145 ENOG41090FC Bacteriophage N4 receptor, outer membrane subunit HVZ20_06150 ENOG410802X bacteriophage n4 adsorption protein b HVZ20_06155 ENOG4105GR3 Histidine kinase HVZ20_06160 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HVZ20_06165 ENOG4105ENJ RND efflux system, outer membrane lipoprotein HVZ20_06170 ENOG410624V efflux system protein HVZ20_06175 ENOG4105EP1 Efflux transporter rnd family, mfp subunit HVZ20_06180 ENOG4108IJF Heavy metal efflux pump, CzcA HVZ20_06185 ENOG4105C85 amino acid HVZ20_06190 ENOG4105CUY Mechanosensitive ion channel HVZ20_06195 ENOG4108RCM Nitroreductase HVZ20_06205 ENOG4105MSB protein, conserved in bacteria HVZ20_06210 ENOG4105WQ6 Membrane HVZ20_06220 ENOG4107635 Hok Gef family protein HVZ20_06225 ENOG4108SER Transposase HVZ20_06230 ENOG4108TSE Transferase HVZ20_06235 ENOG4107RNH Outer membrane receptor FepA HVZ20_06240 ENOG4105E93 esterase HVZ20_06245 ENOG41085A6 mbth domain-containing protein HVZ20_06250 ENOG4105C0W non-ribosomal peptide synthetase HVZ20_06260 ENOG4105E0A ABC, transporter HVZ20_06265 ENOG4105TVJ transport system, permease HVZ20_06270 ENOG4105DQ5 transport system permease protein HVZ20_06280 ENOG4105PEC Iron-enterobactin transporter periplasmic binding protein HVZ20_06285 ENOG4105E4F Isochorismate synthase HVZ20_06290 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase HVZ20_06295 ENOG4105WQI isochorismatase HVZ20_06300 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase HVZ20_06305 ENOG4108TZA Required for optimal enterobactin synthesis. Acts as a proofreading enzyme that prevents EntB misacylation by hydrolyzing the thioester bound existing between EntB and wrongly charged molecules (By similarity) HVZ20_06310 ENOG4105D22 carbon starvation protein HVZ20_06315 ENOG4105VCD cytoplasmic protein HVZ20_06320 ENOG4107SCQ Iron-containing alcohol dehydrogenase HVZ20_06325 ENOG4105CHM Aminotransferase HVZ20_06330 ENOG4105GTN ParB Domain Protein Nuclease HVZ20_06350 ENOG4105DQS Transcriptional regulator HVZ20_06355 ENOG4108KHN disulfide isomerase, thiol-disulfide oxidase HVZ20_06360 ENOG4105D3R alkyl hydroperoxide reductase HVZ20_06365 ENOG4108JU3 Alkyl hydroperoxide reductase HVZ20_06370 ENOG4108U51 Universal stress protein HVZ20_06375 ENOG4105NXH GreA GreB family elongation factor HVZ20_06380 ENOG4105KTS ribonuclease HVZ20_06385 ENOG4107QPK )-transporter HVZ20_06400 ENOG4105CHY citrate lyase, alpha HVZ20_06405 ENOG4105CI0 Citrate lyase HVZ20_06415 ENOG4105DUA (citrate (pro-3S)-lyase ligase HVZ20_06420 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism HVZ20_06425 ENOG4106YYS transcriptional regulatory protein HVZ20_06430 ENOG4105CEE C4-dicarboxylate transporter HVZ20_06435 ENOG41079UR PagP is required both for biosynthesis of hepta-acylated lipid A species containing palmitate and for resistance to cationic antimicrobial peptides (CAMPs). It catalyzes the transfer of a palmitate chain (16 0) from the sn-1 position of a glycerophospholipid to the free hydroxyl group of the (R)-3- hydroxymyristate chain at position 2 of lipid A (endotoxin) (By similarity) HVZ20_06455 ENOG410607N Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatE shares overlapping functions with TatA (By similarity) HVZ20_06480 ENOG4105DZ1 carboxypeptidase HVZ20_06485 ENOG4105K6T rare lipoprotein A HVZ20_06490 ENOG4105CNI cell division protein FtsW HVZ20_06495 ENOG4105CJN penicillin-binding protein HVZ20_06505 ENOG4105KEM Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) HVZ20_06510 ENOG4108TGR phosphatase HVZ20_06520 ENOG4105DJF DNA polymerase III, delta' subunit HVZ20_06535 ENOG4107PAI alpha helical protein HVZ20_06545 ENOG4105CDA abc transporter atp-binding protein HVZ20_06550 ENOG4105DRP amino acid AbC transporter HVZ20_06555 ENOG4105EAD ABC transporter HVZ20_06560 ENOG4107RP9 extracellular solute-binding protein, family 3 HVZ20_06565 ENOG4107U91 Rhomboid family HVZ20_06570 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) HVZ20_06575 ENOG4108JU5 Magnesium and cobalt efflux protein HVZ20_06585 ENOG4105C9A Phoh family HVZ20_06595 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family HVZ20_06635 ENOG4105CAQ asparagine synthetase HVZ20_06640 ENOG4105D4U had-superfamily hydrolase, subfamily iia HVZ20_06645 ENOG4105E2R ROK family HVZ20_06650 ENOG4105CE4 GlcNAc 6-P deacetylase HVZ20_06660 ENOG4105CI1 PTS System HVZ20_06680 ENOG4105EE5 Membrane protein terC HVZ20_06685 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) HVZ20_06695 ENOG4107S2N Type III effector Hrp-dependent HVZ20_06700 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) HVZ20_06705 ENOG4105MVE transcriptional regulator HVZ20_06720 ENOG4105GX6 (LipO)protein HVZ20_06725 ENOG41090R7 Ferric uptake HVZ20_06735 ENOG4105MHQ Low-potential electron donor to a number of redox enzymes (By similarity) HVZ20_06740 ENOG4105NNH LexA regulated protein HVZ20_06745 ENOG4105EV9 Alpha Beta Hydrolase HVZ20_06750 ENOG4107CDU Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated (By similarity) HVZ20_06755 ENOG4107QIX Phosphoglucomutase (EC 5.4.2.2 HVZ20_06760 ENOG4105D5Q Arginine ornithine antiporter HVZ20_06765 ENOG4105CXN decarboxylase HVZ20_06775 ENOG4105EEX Two component transcriptional regulator (Winged helix family HVZ20_06780 ENOG4105C08 Histidine kinase HVZ20_06805 ENOG4105XIQ Protein of unknown function (DUF2517) HVZ20_06810 ENOG4107SEY Conserved Protein HVZ20_06815 ENOG4105CVP deoxyribo-dipyrimidine photolyase HVZ20_06820 ENOG4105DUX Transporter HVZ20_06825 ENOG4107QNR UPF0135 protein HVZ20_06830 ENOG4105P4J Allophanate hydrolase, subunit 1 HVZ20_06835 ENOG4107R7A Allophanate hydrolase subunit 2 HVZ20_06840 ENOG4105E7W lamb ycsf family protein HVZ20_06850 ENOG4108KK1 membrane protein AbrB duplication HVZ20_06855 ENOG41073TP transcriptional regulator HVZ20_06860 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) HVZ20_06865 ENOG4105CPQ Dehydrogenase HVZ20_06870 ENOG4105CHR reductase HVZ20_06880 ENOG4105CTX dehydratase HVZ20_06885 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit HVZ20_06895 ENOG4105CG6 trap dicarboxylate transporter dctm subunit HVZ20_06900 ENOG4105BZN citrate synthase HVZ20_06910 ENOG4108UTY succinate dehydrogenase, cytochrome b556 subunit HVZ20_06915 ENOG4105N1I succinate dehydrogenase, hydrophobic membrane anchor protein HVZ20_06920 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) HVZ20_06925 ENOG4105E33 succinate dehydrogenase HVZ20_06930 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 HVZ20_06935 ENOG4105C7S Dehydrogenase HVZ20_06945 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha HVZ20_06955 ENOG4105C4M (Ubiquinol oxidase) subunit I HVZ20_06960 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii HVZ20_06970 ENOG4105KJB cyd operon protein YbgE HVZ20_06975 ENOG4107YD3 Thioesterase HVZ20_06980 ENOG4105E02 MotA TolQ exbB proton channel HVZ20_06990 ENOG4108Z82 Cell envelope integrity inner membrane protein TolA HVZ20_07000 ENOG4105KCK Peptidoglycan-associated lipoprotein HVZ20_07005 ENOG4105UFD tol-pal system protein YbgF HVZ20_07050 ENOG4106Z1T Nicotinamide Mononucleotide Transporter HVZ20_07055 ENOG4105PGM cation diffusion facilitator family transporter HVZ20_07060 ENOG4105JND homeobox protein HVZ20_07065 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) HVZ20_07075 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) HVZ20_07085 ENOG4105F0Z galactose-1-phosphate uridylyltransferase HVZ20_07090 ENOG4105CMR udp-glucose 4-epimerase HVZ20_07095 ENOG4105DKW ABC transporter HVZ20_07100 ENOG4105F4R Transcriptional regulator mode HVZ20_07110 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein HVZ20_07115 ENOG4105E0C molybdate abc transporter HVZ20_07120 ENOG4105CGB Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system (By similarity) HVZ20_07125 ENOG4108K4B hydrolase HVZ20_07135 ENOG4105F04 LysR family Transcriptional regulator HVZ20_07140 ENOG4105C7F AcnD-accessory protein PrpF HVZ20_07160 ENOG4107QM5 aconitate hydratase HVZ20_07185 ENOG410757E Protein NinE homolog from lambdoid prophage DLP12 HVZ20_07190 ENOG4105RWQ Protein of unknown function (DUF1364) HVZ20_07195 ENOG4106CZA Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC (By similarity) HVZ20_07225 ENOG4105QFS Lysis protein S homolog from lambdoid prophage HVZ20_07230 ENOG4105KUS lysozyme HVZ20_07235 ENOG4105SZK Rz endopeptidase from lambdoid prophage DLP12 HVZ20_07245 ENOG4105FKG DNA packaging protein HVZ20_07250 ENOG4105UZW Tail fiber assembly protein HVZ20_07255 ENOG4107DE1 head-to-tail joining protein HVZ20_07265 ENOG4105F7J membrane-bound serine protease HVZ20_07275 ENOG4105IM0 capsid protein HVZ20_07350 ENOG4108X9F tail fiber protein HVZ20_07355 ENOG4105UZW Tail fiber assembly protein HVZ20_07365 ENOG4108V1U phospholipid-binding protein HVZ20_07370 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) HVZ20_07385 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) HVZ20_07390 ENOG4105E78 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) HVZ20_07400 ENOG4105CHW UPF0052 protein HVZ20_07410 ENOG4108RIR Molybdenum cofactor biosynthesis protein HVZ20_07420 ENOG4105M00 molybdopterin converting factor, subunit 1 HVZ20_07425 ENOG4108ZAF Molybdopterin HVZ20_07430 ENOG4105HFZ Membrane HVZ20_07435 ENOG410733J conserved inner membrane protein HVZ20_07440 ENOG4107UXM Membrane HVZ20_07445 ENOG4105DZQ phospholipase D Transphosphatidylase HVZ20_07450 ENOG4105X23 Endonuclease Exonuclease phosphatase HVZ20_07455 ENOG4105I9U inner membrane protein ybhQ HVZ20_07460 ENOG4107QWP ABC-2 type transporter HVZ20_07465 ENOG4107QWP ABC-2 type transporter HVZ20_07470 ENOG4105CJ1 ABC, transporter HVZ20_07480 ENOG4107MVR Transcriptional regulator HVZ20_07485 ENOG4105C1J atp-dependent rna helicase HVZ20_07495 ENOG4105DVT helicase HVZ20_07500 ENOG4108MTB glycosyl transferase family HVZ20_07505 ENOG4105DG4 malate L-lactate dehydrogenase HVZ20_07510 ENOG4105VR4 UPF0379 protein ybiJ HVZ20_07515 ENOG4105KSC Transcriptional regulator, TraR DksA family HVZ20_07530 ENOG4105ZY9 UPF0379 protein ybiM HVZ20_07540 ENOG4105D8X mechanosensitive ion channel HVZ20_07545 ENOG4105CDA abc transporter atp-binding protein HVZ20_07550 ENOG4105E5Q amino acid AbC transporter HVZ20_07560 ENOG4107R0W ABC transporter HVZ20_07570 ENOG4107AQZ Membrane HVZ20_07580 ENOG4108T1M outer membrane protein x HVZ20_07585 ENOG4108I6E Sulfatase HVZ20_07595 ENOG4105KST dependent repressor HVZ20_07600 ENOG4105F4P )-transporter HVZ20_07605 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein HVZ20_07610 ENOG4105C5H ABC transporter HVZ20_07615 ENOG4108HCJ Hydrolase HVZ20_07625 ENOG4105F1A Pyruvate formate-lyase HVZ20_07630 ENOG4107T9Z Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) HVZ20_07635 ENOG4105D06 uba thif-type nad fad binding protein HVZ20_07640 ENOG4105CVM Molybdenum cofactor synthesis domain protein HVZ20_07645 ENOG4105D44 asparaginase HVZ20_07650 ENOG4108JQ6 ABC transporter HVZ20_07655 ENOG4105DEF Extracellular solute-binding protein, family 5 HVZ20_07690 ENOG41064RH membrane protein YliF HVZ20_07715 ENOG4105UFT Represses biofilm formation in M9C glu and LB glu media but not in M9C and LB media. Seems to act as a global regulator of several genes involved in catabolite repression and stress response and regulation of the uptake and export of signaling pathways. Could be involved the regulation of indole as well as uptake and export of AI-2 through a cAMP-dependent pathway HVZ20_07720 ENOG4105D8V Glucose sorbosone dehydrogenase HVZ20_07725 ENOG4108TGY Glutathione S-transferase HVZ20_07730 ENOG4105DZ1 carboxypeptidase HVZ20_07735 ENOG4107FB0 transcriptional regulator DeoR family HVZ20_07740 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase HVZ20_07745 ENOG4107QF7 multi-drug HVZ20_07755 ENOG4108HCJ Hydrolase HVZ20_07760 ENOG4106UW1 Major Facilitator superfamily HVZ20_07765 ENOG4108RFG Tetr family transcriptional regulator HVZ20_07775 ENOG4105GWF inner membrane protein YbjM HVZ20_07780 ENOG41090BQ Glutaredoxin HVZ20_07785 ENOG4105X20 member of the soxRS regulon which mediates in part the increased levels of superoxide in response to oxidative stress HVZ20_07790 ENOG4108DBC nitroreductase HVZ20_07800 ENOG4108RMJ sensory transduction regulator HVZ20_07805 ENOG4107RUE extracellular solute-binding protein family 1 HVZ20_07810 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HVZ20_07815 ENOG4105F38 ABC transporter, permease HVZ20_07820 ENOG4105D38 putrescine abc transporter HVZ20_07825 ENOG4105RBQ inner membrane protein ybjO HVZ20_07835 ENOG4106TNF Periplasmic binding protein HVZ20_07840 ENOG4105DMR ABC, transporter HVZ20_07845 ENOG4105GBT ABC transporter HVZ20_07850 ENOG4106PMH Extracellular solute-binding protein family 3 HVZ20_07855 ENOG4105E5Z arginine transporter ATP-binding subunit HVZ20_07860 ENOG41064MM (LipO)protein HVZ20_07870 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase HVZ20_07875 ENOG4107VBM 3-beta hydroxysteroid dehydrogenase isomerase HVZ20_07880 ENOG4105CGD Nad-dependent epimerase dehydratase HVZ20_07885 ENOG4105C5W Aldolase HVZ20_07890 ENOG4105C7K acetolactate synthase HVZ20_07895 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) HVZ20_07905 ENOG4105DWU Membrane HVZ20_07910 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) HVZ20_07915 ENOG4105CPB ATP-dependent endonuclease of the OLD family HVZ20_07920 ENOG4108MJ5 VirK protein HVZ20_07925 ENOG4105DJY efflux transporter, rnd family, mfp subunit HVZ20_07935 ENOG4105VEQ Cold shock protein HVZ20_07945 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit HVZ20_07955 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) HVZ20_07965 ENOG4108JJ8 (ABC) transporter HVZ20_07970 ENOG4108JJ9 ABC, transporter HVZ20_07975 ENOG4105C3M thioredoxin reductase HVZ20_07985 ENOG4105CNU cell division protein FtsK HVZ20_07995 ENOG4105D1H recombination factor protein RarA HVZ20_08005 ENOG4107QY8 reductase HVZ20_08010 ENOG4105QAX Iron-sulfur HVZ20_08015 ENOG4107KGK dmso reductase anchor subunit HVZ20_08020 ENOG4105CHJ isochorismatase hydrolase HVZ20_08030 ENOG4105F1A Pyruvate formate-lyase HVZ20_08035 ENOG4105C6N Formate acetyltransferase HVZ20_08040 ENOG4105TMB Formate nitrite transporter HVZ20_08045 ENOG4105DDY UPF0142 protein ycaO HVZ20_08050 ENOG4107VMU Membrane HVZ20_08065 ENOG4108K0D peptidase, M48 HVZ20_08075 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) HVZ20_08085 ENOG4108EQH DNA internalization-related competence protein ComEC Rec2 HVZ20_08090 ENOG4105BZ1 (ABC) transporter HVZ20_08100 ENOG4105T0Z Conserved Protein HVZ20_08115 ENOG4107VR7 transferase activity, transferring phosphorus-containing groups HVZ20_08120 ENOG4107S90 membrAne HVZ20_08125 ENOG4106371 Methyltransferase HVZ20_08135 ENOG4105DAH Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF (By similarity) HVZ20_08145 ENOG4105DIT ErfK YbiS YcfS YnhG family protein HVZ20_08155 ENOG4105EAQ (twin-arginine translocation) pathway signal HVZ20_08160 ENOG4105C5X domain protein HVZ20_08165 ENOG4105CGF Aromatic amino acid aminotransferase HVZ20_08185 ENOG4105CD8 aminopeptidase N HVZ20_08195 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component HVZ20_08205 ENOG4105GVF (ABC) transporter HVZ20_08210 ENOG4108UZX fmn reductase HVZ20_08220 ENOG4108T7E Contributes to the efficiency of the cell division process by stabilizing the polymeric form of the cell division protein FtsZ. Acts by promoting interactions between FtsZ protofilaments and suppressing the GTPase activity of FtsZ (By similarity) HVZ20_08225 ENOG4105QVC MOSC domain-containing protein HVZ20_08235 ENOG4105C5H ABC transporter HVZ20_08240 ENOG4105F1S paraquat-inducible protein a HVZ20_08245 ENOG4105DY2 Paraquat-inducible protein b HVZ20_08250 ENOG4108Q2G (LipO)protein HVZ20_08255 ENOG4105WFT During stationary phase, converts 70S ribosomes to an inactive dimeric form (100S ribosomes) (By similarity) HVZ20_08265 ENOG4105DAN ATP-dependent protease HVZ20_08275 ENOG4105UYK outer membrane protein a HVZ20_08285 ENOG4108RZ1 DNA transformation protein HVZ20_08290 ENOG4105EM2 membrane HVZ20_08295 ENOG410901E Membrane HVZ20_08300 ENOG41088T4 Helicase IV HVZ20_08315 ENOG4105K4P CoA-binding domain protein HVZ20_08330 ENOG4105VSY K01512 acylphosphatase EC 3.6.1.7 HVZ20_08335 ENOG4108Z0T Part of a sulfur-relay system (By similarity) HVZ20_08340 ENOG4108MN8 Membrane HVZ20_08360 ENOG4106G8A Qin prophage HVZ20_08415 ENOG4105JBR DNA replication protein HVZ20_08455 ENOG4108MXB Protein of unknown function (DUF968) HVZ20_08460 ENOG4105KSK (crossover) junction endodeoxyribonuclease HVZ20_08465 ENOG4105HRS Antitermination protein HVZ20_08505 ENOG4105QFS Lysis protein S homolog from lambdoid prophage HVZ20_08525 ENOG4105SZK Rz endopeptidase from lambdoid prophage DLP12 HVZ20_08535 ENOG4105UZW Tail fiber assembly protein HVZ20_08560 ENOG4105IM0 capsid protein HVZ20_08635 ENOG4108X9F tail fiber protein HVZ20_08680 ENOG4105E3S small subunit HVZ20_08685 ENOG4105DPX Hydrogenase, large subunit HVZ20_08690 ENOG4105X7T Ni Fe-hydrogenase, b-type cytochrome subunit HVZ20_08695 ENOG4108USZ hydrogenase HVZ20_08700 ENOG4108VXY Hydrogenase-1 operon protein HyaE HVZ20_08705 ENOG4105MVP hydrogenase-1 operon protein HyaF HVZ20_08710 ENOG4105C4M (Ubiquinol oxidase) subunit I HVZ20_08715 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii HVZ20_08725 ENOG4105D6F Phosphatase HVZ20_08735 ENOG4107ZF2 Phosphatase HVZ20_08740 ENOG4105DAY polysaccharide export protein HVZ20_08745 ENOG4105E3R (LipO)protein HVZ20_08750 ENOG4108W78 Pfam:DUF1017 HVZ20_08755 ENOG4108Y9B (LipO)protein HVZ20_08765 ENOG41060EU Cold shock-like protein HVZ20_08770 ENOG4105VEQ Cold shock protein HVZ20_08785 ENOG4106H71 Overexpression increases levels of unsaturated fatty acids and suppresses both the temperature-sensitive fabA6 mutation and cold-sensitive secG null mutation HVZ20_08790 ENOG4105HEE Binding Domain protein HVZ20_08795 ENOG4105BZU Histidine kinase HVZ20_08800 ENOG4108SV3 Tmao reductase system periplasmic protein tort HVZ20_08805 ENOG4106WF9 DNA-binding transcriptional regulator TorR HVZ20_08810 ENOG4105CUW cytochrome C-TYPE protein HVZ20_08815 ENOG4107QY8 reductase HVZ20_08855 ENOG4105XH3 HVZ20_08865 ENOG4107TII Recombinase HVZ20_08920 ENOG4105XF5 Escherichia coli IMT2125 genomic chromosome, IMT2125 HVZ20_08925 ENOG4105C2W permease HVZ20_08930 ENOG4107YAQ Catalyzes the reduction of FMN to FMNH2 which is used to reduce pyrimidine by RutA via the Rut pathway (By similarity) HVZ20_08940 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) HVZ20_08950 ENOG4106XMA In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2 (By similarity) HVZ20_08955 ENOG4105EQP Catalyzes the pyrimidine ring opening between N-3 and C- 4 by an unusual flavin hydroperoxide-catalyzed mechanism to yield ureidoacrylate peracid. It cleaves pyrmidine rings directly by adding oxygen atoms, making a toxic ureidoacrylate peracid product which can be spontaneously reduced to ureidoacrylate (By similarity) HVZ20_08960 ENOG4108R86 Transcriptional regulator HVZ20_08965 ENOG4105C26 Dehydrogenase HVZ20_08975 ENOG4105CK7 Sodium proline symporter HVZ20_08990 ENOG4105DBE peroxidase HVZ20_08995 ENOG4105D5M phosphate starvation-inducible protein HVZ20_09020 ENOG4107XHZ cytoplasmic chaperone TorD family protein HVZ20_09025 ENOG4108UQ5 membrane protein YcdZ HVZ20_09030 ENOG4105P8Q Curli production assembly transport component CsgG HVZ20_09035 ENOG4108WYR Curli production assembly transport component, CsgF HVZ20_09040 ENOG4108XDW curli assembly protein CsgE HVZ20_09045 ENOG41086KC Transcriptional regulator HVZ20_09060 ENOG4108UVJ appr-1-p processing domain protein HVZ20_09065 ENOG4107RZC phospholipase d HVZ20_09080 ENOG4105C3A Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs) (By similarity) HVZ20_09085 ENOG4105NAC (LipO)protein HVZ20_09090 ENOG4108W47 Acidic protein msyB HVZ20_09100 ENOG4105D1S lipid A biosynthesis HVZ20_09110 ENOG4108YYC ycei family HVZ20_09115 ENOG4105DS1 cytochrome b561 HVZ20_09120 ENOG4106974 biofilm formation HVZ20_09135 ENOG4105PVA Biofilm formation regulatory protein BssS HVZ20_09140 ENOG4105MEA DNA damage-inducible protein i HVZ20_09150 ENOG4105F3T (LipO)protein HVZ20_09155 ENOG4105E9S glutaredoxin 2 HVZ20_09165 ENOG4105D9U N-acetyltransferase HVZ20_09175 ENOG4105EP9 oxidoreductase HVZ20_09180 ENOG4105CJR Integral membrane protein (MviN HVZ20_09185 ENOG4105QVD Flagella synthesis protein FlgN HVZ20_09190 ENOG4105M9M anti-sigma28 factor FlgM HVZ20_09195 ENOG4105CKS Flagella basal body P-ring formation protein flgA HVZ20_09200 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) HVZ20_09205 ENOG4108ZC9 flagellar basal-body rod protein flgc HVZ20_09210 ENOG4105W00 Flagellar hook capping protein HVZ20_09215 ENOG4105BZE flagellar hook protein, FlgE HVZ20_09220 ENOG4108KPB Flagellar basal-body rod protein FlgF HVZ20_09225 ENOG4105CGA flagellar basal-body rod protein FlgG HVZ20_09240 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj HVZ20_09245 ENOG4105E1Q flagellar hook-associated protein HVZ20_09250 ENOG4105DTJ flagellar hook-associated protein HVZ20_09265 ENOG4107QQB Ribonuclease E HVZ20_09270 ENOG4105EI2 Pseudouridine synthase HVZ20_09275 ENOG4108UHJ MAF-like protein HVZ20_09280 ENOG4105FCQ metal-binding, possibly nucleic acid-binding protein HVZ20_09300 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase HVZ20_09305 ENOG4105CHR reductase HVZ20_09310 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) HVZ20_09315 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) HVZ20_09320 ENOG4105YAZ 4-amino-4-deoxychorismate lyase HVZ20_09325 ENOG4105HHA aminodeoxychorismate lyase HVZ20_09335 ENOG4107QRG dna polymerase iii HVZ20_09340 ENOG4105F8V Hydrolase, tatD family HVZ20_09345 ENOG4105CI1 PTS System HVZ20_09350 ENOG4105CNM Receptor HVZ20_09355 ENOG4105K59 histidine triad (HIT) protein HVZ20_09360 ENOG41090DQ Lipoprotein HVZ20_09365 ENOG4108WEF Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b) (By similarity) HVZ20_09385 ENOG4105CEP NADH dehydrogenase HVZ20_09390 ENOG4107MBR 17 kDa surface antigen HVZ20_09395 ENOG4108IND Tetr family transcriptional regulator HVZ20_09400 ENOG4105RC8 Reduces the permeability of the outer membrane to copper. Seems to be involved in the regulation of biofilm formation. May decrease biofilm formation by repressing cell-cell interaction and cell surface interaction HVZ20_09405 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein HVZ20_09410 ENOG4108JA2 transcriptioN-repair coupling factor HVZ20_09415 ENOG4105IQC Inner membrane protein YcfT HVZ20_09420 ENOG4105D60 lipoprotein releasing system transmembrane protein HVZ20_09425 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) HVZ20_09430 ENOG4105D60 lipoprotein releasing system transmembrane protein HVZ20_09440 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) HVZ20_09465 ENOG4107RUE extracellular solute-binding protein family 1 HVZ20_09470 ENOG4105D38 putrescine abc transporter HVZ20_09475 ENOG4108I1J Integrase HVZ20_09490 ENOG4106G8A Qin prophage HVZ20_09505 ENOG4107712 HVZ20_09515 ENOG410649Z repressor HVZ20_09520 ENOG4105W7J DNA binding HVZ20_09535 ENOG4105JBR DNA replication protein HVZ20_09555 ENOG4105WI6 cell killing protein encoded within cryptic prophage HVZ20_09560 ENOG4108SER Transposase HVZ20_09575 ENOG4108MXB Protein of unknown function (DUF968) HVZ20_09580 ENOG4105KSK (crossover) junction endodeoxyribonuclease HVZ20_09585 ENOG4105HGD Antitermination protein HVZ20_09605 ENOG4105QFS Lysis protein S homolog from lambdoid prophage HVZ20_09645 ENOG4106YSC HVZ20_09650 ENOG4105FKG DNA packaging protein HVZ20_09655 ENOG4105UZW Tail fiber assembly protein HVZ20_09660 ENOG4107DE1 head-to-tail joining protein HVZ20_09670 ENOG4105F7J membrane-bound serine protease HVZ20_09680 ENOG4105IM0 capsid protein HVZ20_09755 ENOG4108X9F tail fiber protein HVZ20_09775 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HVZ20_09785 ENOG4105EZE Cupin 4 family protein HVZ20_09790 ENOG4105IFJ Histidine kinase HVZ20_09795 ENOG4105XJC Two component transcriptional regulator (Winged helix family HVZ20_09800 ENOG4107QTF adenylosuccinate lyase HVZ20_09825 ENOG4108HMX isocitrate dehydrogenase (NADP) HVZ20_09835 ENOG41064WM Uncharacterized protein YcgX HVZ20_09840 ENOG4108XDN Transcriptional regulator HVZ20_09855 ENOG4105BZU Histidine kinase HVZ20_09860 ENOG4105WKE Probably a connector protein for RcsB C regulation of biofilm formation, providing additional signal input into the two- component signaling pathway. Partially antagonizes the activities of YmgA and AriR, proteins that, via the Rcs phosphorelay, promote the synthesis of colanic acid, an exopolysaccharide and matrix component HVZ20_09865 ENOG41077SS Probably a connector protein for RcsB C regulation of biofilm formation, providing additional signal input into the two- component signaling pathway. May serve to stimulate biofilm maturation, probably via the Rcs phosphorelay. Mild overexpression at 16 degrees Celsius increases the production of colanic acid, an exopolysaccharide and matrix component, and reduces adhesive curli fimbriae expression. Both of these effects require RcsB HVZ20_09875 ENOG410738I uncharacterized protein ymgC HVZ20_09900 ENOG410658X HVZ20_09935 ENOG4107QMS site-determining protein HVZ20_09940 ENOG4105K7U Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) HVZ20_09945 ENOG4105S66 prophage protein HVZ20_09950 ENOG41066UD Inhibits activity of g-type lysozyme, which confers increased lysozyme tolerance to the bacterium HVZ20_09960 ENOG4105FBJ fumarylacetoacetate (faa) hydrolase HVZ20_09965 ENOG4108ZZ3 UPF0260 protein HVZ20_09970 ENOG4106PXS Toxin, which has some hemolytic activity towards mammalian cells. Acts by forming a pore-like structure upon contact with mammalian cells HVZ20_09975 ENOG4105KT5 UmuD protein HVZ20_09980 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) HVZ20_09985 ENOG410635M Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein (By similarity) HVZ20_10000 ENOG4105ED1 spovr family HVZ20_10010 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) HVZ20_10020 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A HVZ20_10030 ENOG4108T7K Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Increasing levels of c-di-GMP lead to decreased motility (By similarity) HVZ20_10050 ENOG4108BSC Methyltransferase HVZ20_10055 ENOG4105E0A ABC, transporter HVZ20_10060 ENOG4105EHG Permease protein HVZ20_10065 ENOG4105S10 periplasmic binding protein HVZ20_10070 ENOG4105E53 ec 3.2.1.28 HVZ20_10075 ENOG4105VDH Dihydroxyacetone kinase HVZ20_10080 ENOG4108UTZ Dihydroxyacetone kinase HVZ20_10085 ENOG4105CMT Dihydroxyacetone kinase HVZ20_10090 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family HVZ20_10100 ENOG4105C3G gtp-binding protein HVZ20_10110 ENOG4105MGX transcription activated by CRP (cyclic AMP receptor protein), a global transcription factor involved in regulation of metabolism in enteric bacteria HVZ20_10115 ENOG4105CHH sulfate transporter HVZ20_10120 ENOG4105C5T Phosphoribosyl pyrophosphate synthase HVZ20_10130 ENOG4105C1U Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein (By similarity) HVZ20_10145 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) HVZ20_10150 ENOG4108YY7 Invasion gene expression up-regulator SirB HVZ20_10155 ENOG41063JG Transcriptional regulator HVZ20_10175 ENOG4105EWV Sodium calcium exchanger membrane region HVZ20_10180 ENOG4105WS7 Cation transport regulator HVZ20_10185 ENOG4108NH8 Cation transport protein HVZ20_10190 ENOG41090EX DsrE family HVZ20_10195 ENOG4105ID0 Putative invasin HVZ20_10200 ENOG4105WH1 Two component transcriptional regulator luxr family HVZ20_10205 ENOG4105BZU Histidine kinase HVZ20_10210 ENOG4105DQQ Major facilitator superfamily MFS_1 HVZ20_10215 ENOG4105CRU nitrate reductase, alpha subunit HVZ20_10220 ENOG4108IUE nitrate reductase beta subunit HVZ20_10225 ENOG4105R3A Nitrate reductase HVZ20_10230 ENOG41076YT nitrate reductase, gamma subunit HVZ20_10240 ENOG4107VBM 3-beta hydroxysteroid dehydrogenase isomerase HVZ20_10280 ENOG4105CIY formyltetrahydrofolate deformylase HVZ20_10290 ENOG4105D78 K07001 NTE family protein HVZ20_10295 ENOG4105I93 response regulator HVZ20_10300 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase HVZ20_10305 ENOG4108SAU DNA-binding protein H-ns HVZ20_10310 ENOG4107104 thymidine kinase HVZ20_10320 ENOG4105C0A alcohol dehydrogenase HVZ20_10325 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein HVZ20_10335 ENOG4108J59 Extracellular solute-binding protein, family 5 HVZ20_10340 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HVZ20_10345 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HVZ20_10350 ENOG4105C3U ABC transporter HVZ20_10355 ENOG4108JQ7 (ABC) transporter HVZ20_10375 ENOG4107SVH Potassium channel protein HVZ20_10380 ENOG4105K9H YciI-like protein HVZ20_10385 ENOG410822N TonB family HVZ20_10390 ENOG4105NAU thioesterase Superfamily protein HVZ20_10410 ENOG4105EIF outer membrane protein W HVZ20_10425 ENOG4105DK0 Indole-3-glycerol phosphate synthase HVZ20_10430 ENOG4108EFP Anthranilate synthase component II HVZ20_10435 ENOG4105CRQ synthase (Component I) HVZ20_10445 ENOG4105DB7 PHP domain protein HVZ20_10450 ENOG4107RTD sua5 ycio yrdc ywlc family protein HVZ20_10470 ENOG4105FE9 pseudouridine synthase HVZ20_10475 ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase HVZ20_10480 ENOG4105UBK short-chain dehydrogenase reductase HVZ20_10485 ENOG4105ERU peptidase HVZ20_10490 ENOG4105RKX Protein of unknown function (DUF2498) HVZ20_10495 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) HVZ20_10500 ENOG4107R11 Transcriptional regulator HVZ20_10520 ENOG4107QM5 aconitate hydratase HVZ20_10530 ENOG4105EYK Phosphatidylglycerophosphatase B HVZ20_10535 ENOG4105Q4A inner membrane protein yciS HVZ20_10540 ENOG4105CFV Tetratricopeptide repeat protein HVZ20_10550 ENOG4108ZJT translation initiation factor, Sui1 HVZ20_10560 ENOG4105N2W Transcriptional regulator HVZ20_10565 ENOG410643D UPF0509 protein HVZ20_10570 ENOG4105BZU Histidine kinase HVZ20_10580 ENOG4108IEC Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction (By similarity) HVZ20_10585 ENOG4105Q4T oxidoreductase HVZ20_10590 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH HVZ20_10595 ENOG41067SE Tetr family transcriptional regulator HVZ20_10600 ENOG4105C1P efflux transporter, rnd family, mfp subunit HVZ20_10605 ENOG4105BZS acriflavin resistance protein HVZ20_10610 ENOG4105ENJ RND efflux system, outer membrane lipoprotein HVZ20_10615 ENOG4105C2C drug resistance transporter, Bcr CflA HVZ20_10620 ENOG4108JQ2 peptide transport system atp-binding protein HVZ20_10625 ENOG4108JQ3 Peptide ABC transporter ATP-binding protein HVZ20_10630 ENOG4108EU3 peptide transport system, permease HVZ20_10635 ENOG4108I5W peptide transport system, permease protein HVZ20_10640 ENOG4108HIY periplasmic HVZ20_10645 ENOG4105N0E Protein of unknown function (DUF2543) HVZ20_10650 ENOG4105E51 psp operon transcriptional activator HVZ20_10655 ENOG41087YS Phage shock protein A HVZ20_10660 ENOG4105YYT phage shock protein B HVZ20_10665 ENOG4105FM1 phage shock protein C HVZ20_10670 ENOG4105NNG Peripheral inner membrane phage-shock protein HVZ20_10675 ENOG4105K8Z Phage shock protein HVZ20_10680 ENOG4107QW3 Sucrose phosphorylase HVZ20_10685 ENOG4105WEM extracellular solute-binding protein HVZ20_10690 ENOG4105HS6 binding-protein-dependent transport systems inner membrane Component HVZ20_10695 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component HVZ20_10700 ENOG4107RRD Dehydrogenase HVZ20_10705 ENOG4107TYA transient receptor potential locus HVZ20_10710 ENOG4105CK5 oxidoreductase HVZ20_10715 ENOG4105C71 hydrolase family 65, central catalytic HVZ20_10720 ENOG4107URF beta-phospho-glucomutase HVZ20_10725 ENOG4108IJ9 (ABC) transporter HVZ20_10730 ENOG4107EFV Outer membrane protein G HVZ20_10735 ENOG4105FKQ transcriptional regulator HVZ20_10740 ENOG4105CM6 amino acid regulated cytosolic protein HVZ20_10750 ENOG4108JU8 Transcriptional regulator HVZ20_10755 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) HVZ20_10760 ENOG4107S8C mandelate racemase muconate lactonizing HVZ20_10765 ENOG4105KXI murein peptide amidase A HVZ20_10770 ENOG4107QSI ABC, transporter HVZ20_10775 ENOG4105D64 Mechanosensitive ion channel HVZ20_10780 ENOG4105S5I Membrane HVZ20_10785 ENOG4105Q9Y Universal stress protein HVZ20_10790 ENOG4105DS0 Transcriptional regulator, Crp Fnr family HVZ20_10795 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) HVZ20_10800 ENOG4105CFC Transporter HVZ20_10805 ENOG4107RT5 aminobenzoyl-glutamate utilization protein B HVZ20_10810 ENOG4105CH2 amidohydrolase HVZ20_10815 ENOG4106KR7 LysR family Transcriptional regulator HVZ20_10820 ENOG4108DG9 Smr protein MutS2 HVZ20_10825 ENOG4105BZU Histidine kinase HVZ20_10835 ENOG4105C1J atp-dependent rna helicase HVZ20_10880 ENOG4108RW8 Universal stress protein F HVZ20_10885 ENOG4105FCK Membrane HVZ20_10890 ENOG4105D95 Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity) HVZ20_10895 ENOG4105IKK cytoplasmic protein HVZ20_10900 ENOG41090X5 Heat shock protein hslJ HVZ20_10905 ENOG4105C5I Dehydrogenase HVZ20_10910 ENOG4107H52 Dicarboxylate transport HVZ20_10915 ENOG410689M (LipO)protein HVZ20_10920 ENOG4105WXT Conserved Protein HVZ20_10925 ENOG4108WFR AraC Family Transcriptional Regulator HVZ20_10930 ENOG4105V9J phenylacetic acid degradation operon negative regulatory protein HVZ20_10935 ENOG4108Z0R Transferase HVZ20_10940 ENOG4107S5I aldo keto reductase HVZ20_10950 ENOG4105CQ7 ATP-dependent helicase HVZ20_10955 ENOG4108RS6 transposase HVZ20_10960 ENOG4107DB1 DUF218 domain HVZ20_10965 ENOG4105C26 Dehydrogenase HVZ20_10975 ENOG4105CPW cytochrome b561 HVZ20_10980 ENOG4105UPP uncharacterized protein ydcA HVZ20_10985 ENOG4107NK6 Hok/gef family HVZ20_10995 ENOG4105DDW LysR family Transcriptional regulator HVZ20_11000 ENOG4105E32 cytoplasmic protein HVZ20_11010 ENOG4105Z2P Protein of unknown function (DUF465) HVZ20_11015 ENOG4108Z9I -acetyltransferase HVZ20_11020 ENOG4107WE3 acetyltransferase YdcK HVZ20_11025 ENOG4108NKP c4-dicarboxylate transporter malic acid transport protein HVZ20_11030 ENOG41088CC tellurite resistance protein tehB HVZ20_11035 ENOG4108KKZ (LipO)protein HVZ20_11040 ENOG4105DKK Benzoate HVZ20_11045 ENOG4108JCI Transcriptional regulator HVZ20_11050 ENOG4105CFP Peptidase U32 HVZ20_11055 ENOG4105RR0 Protein of unknown function (DUF2554) HVZ20_11065 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HVZ20_11070 ENOG4107TYH extracellular solute-binding protein family 1 HVZ20_11075 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HVZ20_11080 ENOG4105D81 ABC transporter, permease HVZ20_11085 ENOG4105NRK Binding-protein-dependent transport systems, inner membrane component HVZ20_11100 ENOG410654E Membrane HVZ20_11105 ENOG4105R71 cytoplasmic protein HVZ20_11110 ENOG4108T9Y Inner membrane protein ydcZ HVZ20_11115 ENOG4108Z7F N-acetyltransferase HVZ20_11130 ENOG4105CHB tonB-dependent Receptor HVZ20_11135 ENOG4108NS2 receptor HVZ20_11140 ENOG4105C85 amino acid HVZ20_11200 ENOG4108MEJ flavin reductase domain protein HVZ20_11205 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase HVZ20_11210 ENOG4105JAB phenazine biosynthesis protein, phzf family HVZ20_11215 ENOG4105D0D Nitrate reductase 2, gamma subunit HVZ20_11220 ENOG4108NZN Respiratory nitrate reductase 2 delta chain HVZ20_11225 ENOG4108IUE nitrate reductase beta subunit HVZ20_11230 ENOG4105CRU nitrate reductase, alpha subunit HVZ20_11235 ENOG4107QND Nitrite extrusion protein HVZ20_11240 ENOG4105RPH Inner membrane protein YddG HVZ20_11250 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein HVZ20_11255 ENOG4108MG3 formate dehydrogenase HVZ20_11260 ENOG41084S7 Plasmid maintenance system antidote protein HVZ20_11265 ENOG4105DQ4 alcohol dehydrogenase HVZ20_11275 ENOG4107AV5 Although this protein associates with the 30S subunit of the ribosome it is not considered to be a bona fide ribosomal protein HVZ20_11280 ENOG4105TPS biofilm-dependent modulation protein HVZ20_11285 ENOG4108Z9K Osmotically inducible protein HVZ20_11290 ENOG4105BZU Histidine kinase HVZ20_11295 ENOG4105BZU Histidine kinase HVZ20_11295 ENOG4105BZU Histidine kinase HVZ20_11300 ENOG4105F32 YngK protein HVZ20_11305 ENOG4105E5D amino acid HVZ20_11310 ENOG4105CVK Glutamate decarboxylase HVZ20_11315 ENOG4107RAN Peptidase, M16 HVZ20_11320 ENOG4105PE1 Receptor HVZ20_11325 ENOG4105CQ0 ABC transporter HVZ20_11335 ENOG4105C4X radical SAM domain protein HVZ20_11340 ENOG4105ENH Sulfatase HVZ20_11360 ENOG4107QKC Oxidoreductase alpha (molybdopterin) subunit HVZ20_11365 ENOG4106PIH fimbrial-like protein ydeQ HVZ20_11370 ENOG4106318 fimbrial-like protein YdeR HVZ20_11375 ENOG4108WDE Fimbrial protein HVZ20_11380 ENOG4105CW0 outer membrane usher protein HVZ20_11390 ENOG4108RQP Major type 1 subunit fimbrin HVZ20_11395 ENOG4105CGD Nad-dependent epimerase dehydratase HVZ20_11440 ENOG4105CAF HipA N-terminal domain protein HVZ20_11445 ENOG41061P8 Persistence to inhibition of murein or DNA biosynthesis regulatory protein HVZ20_11455 ENOG4105FFC UPF0187 protein HVZ20_11470 ENOG4105M0C cytoplasmic protein HVZ20_11475 ENOG4105CSV Glutaminase HVZ20_11480 ENOG4105C26 Dehydrogenase HVZ20_11485 ENOG4105EGI Transcriptional regulator HVZ20_11505 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes HVZ20_11510 ENOG4108XW0 May be a transcriptional activator of genes involved in the multiple antibiotic resistance (Mar) phenotype. It can also activate genes such as sodA, zwf and micF HVZ20_11515 ENOG4106DNR multiple antibiotic resistance protein HVZ20_11520 ENOG4108594 Permease of the drug metabolite transporter HVZ20_11525 ENOG4105E5W Transporter HVZ20_11535 ENOG4105FSR swimming returnes to normal when residues 206-207 are both mutated to Ala. Overexpression also leads to a reduction in flagellar abundance and a 20-fold increase in c-di- GMP levels in vivo. Required for aminoglycoside-mediated induction of biofilm formation, it also plays a lesser role in biofilm production in response to other classes of translation inhibitors. The c-di-GMP produced by this enzyme up-regulates poly-GlcNAc production as well as the biofilm synthesis protein PgaD, although c-di-GMP is probably not the main inducing principle. Cyclic-di- GMP is a second messenger which controls cell surface-associated traits in bacteria HVZ20_11540 ENOG4108YDI single-species biofilm formation on inanimate substrate HVZ20_11545 ENOG4105DGW oligopeptidase A HVZ20_11550 ENOG4105EMU Dehydrogenase HVZ20_11555 ENOG4107XBN GntR Family Transcriptional Regulator HVZ20_11560 ENOG41061EV selenium-binding protein YdfZ HVZ20_11565 ENOG4105DEI Mannitol dehydrogenase HVZ20_11585 ENOG4105CPQ Dehydrogenase HVZ20_11590 ENOG4105CXK mandelate racemase muconate lactonizing HVZ20_11605 ENOG4108MK9 spermidine N(1)-acetyltransferase HVZ20_11615 ENOG4105KBG Protein of unknown function (DUF1161) HVZ20_11620 ENOG4107QY8 reductase HVZ20_11630 ENOG4105QAX Iron-sulfur HVZ20_11635 ENOG4107KGK dmso reductase anchor subunit HVZ20_11640 ENOG4108NEM leader-binding protein dmsD HVZ20_11650 ENOG4105EWW Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) HVZ20_11655 ENOG4105DAG ROK family HVZ20_11660 ENOG4106NZI LysR family Transcriptional regulator HVZ20_11665 ENOG4105D94 Major Facilitator Superfamily HVZ20_11680 ENOG4105CVW peptidase s1 and s6 chymotrypsin hap HVZ20_11695 ENOG4105DSF transport protein HVZ20_11700 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) HVZ20_11705 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) HVZ20_11710 ENOG4105C5D exported protein HVZ20_11715 ENOG4105D5Q Arginine ornithine antiporter HVZ20_11720 ENOG410642E Short chain dehydrogenase HVZ20_11725 ENOG4105RA2 Membrane HVZ20_11730 ENOG4107EXC regulatoR HVZ20_11735 ENOG4105JJR Histidine kinase HVZ20_11740 ENOG4105KR1 Trans-acting protein required for termination of DNA replication. Binds to DNA replication terminator sequences (terA to terF) to prevent the passage of replication forks. The termination efficiency will be affected by the affinity of this protein for the terminator sequence (By similarity) HVZ20_11745 ENOG4105C9Q fumarate hydratase class II HVZ20_11750 ENOG4107GFK fumarate HVZ20_11755 ENOG4105EIP mannose-6-phosphate isomerase HVZ20_11760 ENOG4106J39 exported protein HVZ20_11765 ENOG4108QNI outer membrane porin protein HVZ20_11770 ENOG4105CT4 transporter HVZ20_11775 ENOG4105CNT hydrolase family 2 HVZ20_11780 ENOG4105XEA Tetr family transcriptional regulator HVZ20_11785 ENOG4107ZQV short-chain dehydrogenase reductase HVZ20_11790 ENOG4107P2S Transcriptional regulator HVZ20_11795 ENOG4105CI1 PTS System HVZ20_11800 ENOG4105C87 Aminotransferase class I and II HVZ20_11810 ENOG4105D9R oxidoreductase HVZ20_11815 ENOG4106C6R beta-lactam resistance protein HVZ20_11820 ENOG4105QZ5 OriC-binding nucleoid-associated protein HVZ20_11825 ENOG4105M9B inner membrane protein ydgK HVZ20_11840 ENOG4107QTR Required for nitrogen fixation. May be part of a membrane complex functioning as an intermediate in the electron transport to nitrogenase (By similarity) HVZ20_11850 ENOG4108UQQ Electron transport complex HVZ20_11860 ENOG4105CSM endonuclease III HVZ20_11865 ENOG4105DUX Transporter HVZ20_11870 ENOG4108K3A Glutathione S-transferase HVZ20_11875 ENOG4107XGF functions in a salvage pathway. Uses pyridoxamine (By similarity) HVZ20_11890 ENOG410642K Lysozyme inhibitor HVZ20_11900 ENOG4108XTF Outer Membrane Lipoprotein HVZ20_11915 ENOG4105Y49 secretion protein, HlyD family HVZ20_11920 ENOG4105DSW Fusaric acid resistance protein HVZ20_11925 ENOG4108Z7T Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) HVZ20_11930 ENOG4107RGM aldo keto reductase HVZ20_11935 ENOG4105XZD Fe-S protein HVZ20_11940 ENOG4108WUH Transcriptional regulator, TetR family HVZ20_11945 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HVZ20_11950 ENOG4108UYE Lactoylglutathione lyase HVZ20_11960 ENOG4105M2J Glutaredoxin HVZ20_11965 ENOG4105K4H Nlp p60 protein HVZ20_11970 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) HVZ20_11975 ENOG4105F27 Major Facilitator HVZ20_11990 ENOG4105F52 Transcriptional regulator HVZ20_11995 ENOG4105CZQ inner membrane transport protein YdhC HVZ20_12000 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase HVZ20_12005 ENOG4108R6K riboflavin synthase, subunit alpha HVZ20_12030 ENOG4105N0V mono-oxygenase ydhR HVZ20_12035 ENOG4108KTU conserved protein with FAD NAD(P)-binding domain HVZ20_12040 ENOG4108Y7C Conserved Protein HVZ20_12045 ENOG4108NWD Cytochrome HVZ20_12050 ENOG4108393 oxidoreductase Fe-S subunit HVZ20_12055 ENOG4105JVW HVZ20_12060 ENOG4105WE2 aldehyde ferredoxin oxidoreductase HVZ20_12065 ENOG4108PU5 4fe-4S ferredoxin, iron-sulfur binding domain protein HVZ20_12080 ENOG4105RFR Protein of unknown function (DUF2767) HVZ20_12085 ENOG4105CA9 Pyruvate kinase HVZ20_12090 ENOG4105KMX major outer membrane lipoprotein HVZ20_12095 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein HVZ20_12110 ENOG4105JRK feS assembly protein SufD HVZ20_12115 ENOG4105C3K feS assembly ATPase SufC HVZ20_12120 ENOG4105DIW FeS assembly protein SUFB HVZ20_12125 ENOG4108Z4V iron-sulfur cluster assembly HVZ20_12130 ENOG410671Z uncharacterized protein ydiH HVZ20_12135 ENOG4105KA0 thioesterase Superfamily protein HVZ20_12140 ENOG4105CQB FAD linked oxidase domain protein HVZ20_12145 ENOG4105IPI Membrane HVZ20_12155 ENOG4105SUA Ydil protein HVZ20_12165 ENOG4105EMV Major Facilitator HVZ20_12170 ENOG4105EMV Major Facilitator HVZ20_12185 ENOG4107R0K CoA transferase having broad substrate specificity for short-chain acyl-CoA thioesters with the activity decreasing when the length of the carboxylic acid chain exceeds four carbons (By similarity) HVZ20_12190 ENOG4105C1G acyl-Coa dehydrogenase HVZ20_12195 ENOG4105W4W Transcriptional regulator HVZ20_12200 ENOG4105CV7 Electron transfer flavoprotein HVZ20_12205 ENOG4105C10 Electron transfer flavoprotein HVZ20_12210 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase HVZ20_12215 ENOG41090P5 ferredoxin-like protein HVZ20_12220 ENOG4105CEY Amp-dependent synthetase and ligase HVZ20_12225 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) HVZ20_12235 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) HVZ20_12250 ENOG4108TC0 Diguanylate phosphodiesterase HVZ20_12255 ENOG4108QBX (LipO)protein HVZ20_12265 ENOG4108V06 Glutathione peroxidase HVZ20_12300 ENOG41082NX 50s ribosomal protein l35 HVZ20_12305 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) HVZ20_12325 ENOG4108NE3 Salt-induced outer membrane protein HVZ20_12330 ENOG4105DE4 1-phosphofructokinase HVZ20_12335 ENOG4105P10 Uncharacterized protein ydiZ HVZ20_12345 ENOG4107PN8 YfeABCD locus regulator HVZ20_12350 ENOG4107UW8 HAD-superfamily hydrolase subfamily IA variant 3 HVZ20_12355 ENOG4107K5X Membrane-bound metal-dependent hydrolase HVZ20_12360 ENOG4108ETY sodium dicarboxylate symporter HVZ20_12370 ENOG4105CH6 catalase HVZ20_12380 ENOG4105F8D glycoside hydrolase family 4 HVZ20_12385 ENOG4105EZV Transcriptional regulator HVZ20_12390 ENOG4105VCP PTS System HVZ20_12395 ENOG4105CK1 PTS System HVZ20_12400 ENOG4105VZJ PTS System HVZ20_12405 ENOG4105KKI DNA-binding transcriptional activator OsmE HVZ20_12410 ENOG4107RA1 nh(3)-dependent nad( ) synthetase HVZ20_12415 ENOG4105DKD Incises the DNA at the 3' side of a lesion during nucleotide excision repair. Incises the DNA farther away from the lesion than UvrC. Not able to incise the 5' site of a lesion. When a lesion remains because UvrC is not able to induce the 3' incision, Cho incises the DNA. Then UvrC makes the 5' incision. The combined action of Cho and UvrC broadens the substrate range of nucleotide excision repair (By similarity) HVZ20_12425 ENOG4108SPG Periplasmic Protein HVZ20_12455 ENOG4105CGK Exodeoxyribonuclease III HVZ20_12460 ENOG4108RSN SNARE associated Golgi HVZ20_12465 ENOG4108KCW iron-sulfur cluster binding HVZ20_12470 ENOG4108N5C SNARE associated Golgi protein-related protein HVZ20_12475 ENOG4107ZN8 Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) HVZ20_12485 ENOG4105CXZ ABC transporter, permease HVZ20_12490 ENOG4108VGW abc transporter atp-binding protein HVZ20_12495 ENOG4107RM6 sulfurtransferase HVZ20_12500 ENOG4108T9J Cdp-alcohol phosphatidyltransferase HVZ20_12505 ENOG4105M6F mutator MutT protein HVZ20_12510 ENOG4105MTM Protein of unknown function (DUF1496) HVZ20_12515 ENOG4105D82 Glutamate dehydrogenase HVZ20_12530 ENOG4105D4F Synthesizes selenophosphate from selenide and ATP (By similarity) HVZ20_12535 ENOG41069NU Nitroreductase HVZ20_12540 ENOG4105D07 Signal peptide peptidase, SppA HVZ20_12545 ENOG4105HDK L-asparaginase HVZ20_12550 ENOG4108RWI nicotinamidase HVZ20_12555 ENOG4108KUU Inner membrane metabolite transport protein ydjE HVZ20_12560 ENOG4105E98 transcriptional regulator DeoR family HVZ20_12565 ENOG4105CPC Aldo Keto reductase HVZ20_12580 ENOG4105VUT cytoplasmic protein HVZ20_12590 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase HVZ20_12595 ENOG4105DSB aldose 1-epimerase HVZ20_12600 ENOG4105CV8 reductase HVZ20_12605 ENOG4105GNX MltA-interacting MipA family protein HVZ20_12610 ENOG4105CYN Serine protein kinase HVZ20_12620 ENOG4106KTS Inner membrane protein yeaI HVZ20_12625 ENOG4108KHP Diguanylate cyclase HVZ20_12630 ENOG4108KXH Ybak prolyl-tRNA synthetase associated HVZ20_12645 ENOG4105R1U AraC Family Transcriptional Regulator HVZ20_12650 ENOG4105DJ2 Major Facilitator Superfamily HVZ20_12655 ENOG4105K78 MarR family Transcriptional regulator HVZ20_12660 ENOG4105UCG Domain of unknown function (DUF333) HVZ20_12665 ENOG410620I Diguanylate cyclase HVZ20_12670 ENOG4106G4W HVZ20_12680 ENOG4105Y3U Transglycosylase-associated protein HVZ20_12685 ENOG4105YP6 Domain of unknown function (DUF1869) HVZ20_12695 ENOG4108SER Transposase HVZ20_12700 ENOG4108YS1 cytoplasmic protein HVZ20_12710 ENOG4105EJC lysr family transcriptional regulator HVZ20_12715 ENOG4105ZIE Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity) HVZ20_12720 ENOG4105CEY Amp-dependent synthetase and ligase HVZ20_12725 ENOG4105Y4Z Outer Membrane Lipoprotein HVZ20_12730 ENOG41072GX Peptidase M22 Glycoprotease HVZ20_12735 ENOG4105DVT helicase HVZ20_12740 ENOG4105M4H endoribonuclease L-psp HVZ20_12745 ENOG4105V2F Uncharacterized protein yoac HVZ20_12755 ENOG4105CRQ synthase (Component I) HVZ20_12765 ENOG4105EJQ L-serine dehydratase HVZ20_12770 ENOG4107XTP (EAL) domain protein HVZ20_12775 ENOG4105EE5 Membrane protein terC HVZ20_12780 ENOG4105DAS pts system HVZ20_12785 ENOG4105ETZ PTS System HVZ20_12790 ENOG4105F3R pts system mannose fructose sorbose family iid HVZ20_12805 ENOG4105DHI Methyltransferase HVZ20_12820 ENOG4105Q3Y exported protein HVZ20_12835 ENOG4105J4Q Transcriptional regulator HVZ20_12840 ENOG4105C0R drug resistance transporter emrb qaca subfamily HVZ20_12845 ENOG4108RS6 transposase HVZ20_12855 ENOG4105CN1 protease HVZ20_12865 ENOG4108ZGC gaf domain protein HVZ20_12870 ENOG4105H2K paraquat-inducible protein a HVZ20_12875 ENOG4105DY2 Paraquat-inducible protein b HVZ20_12885 ENOG4105WT8 Protein of unknown function (DUF1480) HVZ20_12890 ENOG4105UVW uncharacterized protein yebW HVZ20_12895 ENOG4108R1E Serine threonine protein phosphatase 1 HVZ20_12900 ENOG4105NKT exported protein HVZ20_12905 ENOG4108PNC copper resistance HVZ20_12910 ENOG4105FXM Copper resistance protein HVZ20_12915 ENOG4105MPK DNA polymerase III subunit theta HVZ20_12920 ENOG4108YGA nitrilase cyanide hydratase and apolipoprotein n-acyltransferase HVZ20_12925 ENOG4105UMD exodeoxyribonuclease X HVZ20_12930 ENOG4105CUG Oligopeptidase b HVZ20_12935 ENOG4108Q2J Inner membrane protein YebE HVZ20_12945 ENOG4105X2V dna damage-inducible protein HVZ20_12955 ENOG4108UHU Aldolase HVZ20_12960 ENOG4105C01 Dihydroxy-acid dehydratase HVZ20_12965 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase HVZ20_12970 ENOG4106KNT transcriptional regulator HVZ20_12975 ENOG4105CA9 Pyruvate kinase HVZ20_12980 ENOG4105NWR lipid A biosynthesis (Kdo)2-(Lauroyl)-lipid IVA acyltransferase HVZ20_12985 ENOG4105DR5 peptidase HVZ20_12990 ENOG4105NXV High-affinity zinc uptake system protein HVZ20_13000 ENOG4105FAV ABC, transporter HVZ20_13030 ENOG4105CDY transcriptional regulatory protein HVZ20_13035 ENOG4108TIT dATP pyrophosphohydrolase HVZ20_13045 ENOG4105D3W isochorismatase HVZ20_13065 ENOG4108X9F tail fiber protein HVZ20_13185 ENOG4105KUS lysozyme HVZ20_13190 ENOG4105QFS Lysis protein S homolog from lambdoid prophage HVZ20_13230 ENOG4105KSK (crossover) junction endodeoxyribonuclease HVZ20_13240 ENOG4105CDU Replicative dna helicase HVZ20_13245 ENOG4106CVF DNA replication protein HVZ20_13280 ENOG4105DS7 Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair (By similarity) HVZ20_13335 ENOG4107R08 Integrase HVZ20_13340 ENOG41081XQ Conserved Protein HVZ20_13345 ENOG4105WJG Glutathione HVZ20_13360 ENOG4108J2R molybdopterin oxidoreductase HVZ20_13365 ENOG4105CUW cytochrome C-TYPE protein HVZ20_13375 ENOG4106ZCM YecM protein HVZ20_13380 ENOG4105C75 arginyL-tRNA synthetase HVZ20_13385 ENOG4105W13 flagellar protein HVZ20_13395 ENOG4105D00 flagellar biosynthetic protein flhB HVZ20_13400 ENOG4108KCC Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P) (By similarity) HVZ20_13405 ENOG4108VYJ response regulator receiver protein HVZ20_13415 ENOG4105BZU Histidine kinase HVZ20_13425 ENOG4105C8Q Methyl-accepting chemotaxis HVZ20_13430 ENOG4108V3W Chemotaxis protein, CheW HVZ20_13435 ENOG4105CBS Chea signal transduction histidine kinase HVZ20_13440 ENOG4105ER2 Ompa motb domain protein HVZ20_13445 ENOG4107RD7 Flagellar Motor Protein, MotA HVZ20_13450 ENOG4106CIA Functions in complex with FlhD as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region HVZ20_13460 ENOG4108VA4 Universal stress protein HVZ20_13465 ENOG4105C1K alpha-alpha-trehalose-phosphate synthase HVZ20_13470 ENOG4108K4C ec 3.1.3.12 HVZ20_13475 ENOG4105CNN ABC, transporter HVZ20_13485 ENOG4105DMK Periplasmic binding protein LacI transcriptional regulator HVZ20_13490 ENOG4108UEC Ferritin-like protein HVZ20_13495 ENOG4105N4N Protein of unknown function (DUF2766) HVZ20_13505 ENOG4105P23 (LipO)protein HVZ20_13510 ENOG41090A1 ferritin HVZ20_13515 ENOG4105VVZ metal-binding protein HVZ20_13520 ENOG4105E0U tyrosine-specific transport protein HVZ20_13525 ENOG4106RHG Yeca family HVZ20_13555 ENOG4105WH1 Two component transcriptional regulator luxr family HVZ20_13565 ENOG4105XVG cytoplasmic protein HVZ20_13570 ENOG4105VJY transcriptional regulator HVZ20_13575 ENOG4105CDA abc transporter atp-binding protein HVZ20_13580 ENOG4105E5Q amino acid AbC transporter HVZ20_13585 ENOG4105K6H D-cysteine desulfhydrase HVZ20_13590 ENOG4105EAB amino acid AbC transporter HVZ20_13595 ENOG4108M9K flagella biosynthesis protein FliZ HVZ20_13600 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HVZ20_13605 ENOG4105I03 Flagellin HVZ20_13610 ENOG4105DTS flagellar hook-associated HVZ20_13615 ENOG4105MQ3 flagellar protein FliS HVZ20_13625 ENOG4105E5K Alpha-amylase HVZ20_13630 ENOG4108W9D (LipO)protein HVZ20_13635 ENOG41066VF YeeE YedE family protein HVZ20_13645 ENOG4108RAV Conserved protein HVZ20_13650 ENOG4108HF7 Gcn5-related n-acetyltransferase HVZ20_13655 ENOG4105VQ0 flagellar hook-basal body complex protein fliE HVZ20_13660 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) HVZ20_13665 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) HVZ20_13670 ENOG41090PJ Flagellar assembly protein HVZ20_13675 ENOG4108JIR Flagellum-specific ATP synthase HVZ20_13680 ENOG4105GSA Flagellar export protein flij HVZ20_13685 ENOG4105WF4 Flagellar hook-length control protein HVZ20_13690 ENOG4107ZI8 flagellar basal body-associated protein flil HVZ20_13695 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) HVZ20_13700 ENOG4105DD5 Flagellar motor switch protein HVZ20_13705 ENOG4105K0P flagellar biosynthesis protein HVZ20_13710 ENOG4105CN7 Flagellar biosynthetic protein FliP HVZ20_13720 ENOG4105D19 Role in flagellar biosynthesis (By similarity) HVZ20_13745 ENOG4105YX3 cellular response to acidity HVZ20_13750 ENOG4108RS6 transposase HVZ20_13765 ENOG4105BZU Histidine kinase HVZ20_13770 ENOG4105VNZ cytoplasmic protein HVZ20_13775 ENOG4105CKW Inner membrane protein yedI HVZ20_13780 ENOG4105FDR Membrane HVZ20_13785 ENOG41090BB DNA mismatch endonuclease (vsr) HVZ20_13790 ENOG4105DVF Cytosine-specific methyltransferase HVZ20_13795 ENOG4105EST Metal Dependent Phosphohydrolase HVZ20_13800 ENOG4105Y0K Inner membrane protein YedR HVZ20_13805 ENOG4105ZIT Porin Gram-negative type HVZ20_13820 ENOG4107ZY3 Histidine kinase HVZ20_13825 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HVZ20_13830 ENOG4105VT2 5-hydroxyisourate hydrolase HVZ20_13835 ENOG4105CCD The exact function is not known. Can catalyze the reduction of a variety of substrates like dimethyl sulfoxide, trimethylamine N-oxide, phenylmethyl sulfoxide and L-methionine sulfoxide. Cannot reduce cyclic N-oxides. Shows no activity as sulfite oxidase (By similarity) HVZ20_13845 ENOG4108MEK Metal-binding protein YodA HVZ20_13925 ENOG4105CSH Transporter HVZ20_13930 ENOG4105FYV Amp nucleosidase HVZ20_13935 ENOG4105CDY transcriptional regulatory protein HVZ20_13945 ENOG4105UQX Mate efflux family protein HVZ20_13955 ENOG4107R11 Transcriptional regulator HVZ20_13960 ENOG4106P55 Transcriptional regulator HVZ20_13970 ENOG4108PXI ErfK YbiS YcfS YnhG HVZ20_13985 ENOG4108YZT Adenosylcobinamide kinase HVZ20_13990 ENOG4108P62 biosynthesis protein (CbiG) HVZ20_13995 ENOG4107XVH Transcriptional regulator HVZ20_14005 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) HVZ20_14010 ENOG4105KNY Microcompartments protein HVZ20_14015 ENOG4105EHR propanediol utilization protein pduB HVZ20_14020 ENOG4105DMB glycerol dehydratase HVZ20_14025 ENOG4105YCI dehydratase medium subunit HVZ20_14030 ENOG4108ZFT Dehydratase small subunit HVZ20_14035 ENOG41084PW diol glycerol dehydratase reactivating factor large subunit HVZ20_14045 ENOG4105KNY Microcompartments protein HVZ20_14050 ENOG4105KNY Microcompartments protein HVZ20_14055 ENOG4108VPX Involved in 1,2-propanediol (1,2-PD) degradation by catalyzing the conversion of propanoyl-CoA to propanoyl-phosphate (By similarity) HVZ20_14065 ENOG4105WVM ethanolamine utilization protein EutN carboxysome structural protein Ccml HVZ20_14075 ENOG4108EKI Dehydrogenase HVZ20_14080 ENOG4105C0A alcohol dehydrogenase HVZ20_14085 ENOG4107QTR Required for nitrogen fixation. May be part of a membrane complex functioning as an intermediate in the electron transport to nitrogenase (By similarity) HVZ20_14095 ENOG4105M3W utilization protein HVZ20_14100 ENOG4105KTW ethanolamine utilization protein HVZ20_14110 ENOG4105DR8 Membrane HVZ20_14120 ENOG4105DZ1 carboxypeptidase HVZ20_14125 ENOG4105CJB Exodeoxyribonuclease I HVZ20_14130 ENOG4105CUB amino acid HVZ20_14140 ENOG4105EQ1 Transcriptional regulator HVZ20_14145 ENOG4107SRH Nad-dependent epimerase dehydratase HVZ20_14150 ENOG4105KRQ Addiction module toxin, Txe YoeB family HVZ20_14155 ENOG4105VTW prevent-host-death family HVZ20_14170 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) HVZ20_14180 ENOG4105ECC imidazole-glycerol-phosphate dehydratase HVZ20_14185 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) HVZ20_14195 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) HVZ20_14200 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase HVZ20_14205 ENOG4108KPN Confers a modal distribution of chain length on the O- antigen component of lipopolysaccharide (LPS). Gives rise to a reduced number of short chain molecules and increases in numbers of longer molecules, with a modal value of 13 (in strain O111 M92) and of 17 (in strain K12) HVZ20_14210 ENOG4105C6Y Udp-glucose 6-dehydrogenase HVZ20_14215 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) HVZ20_14220 ENOG4107QKV phosphomannomutase HVZ20_14230 ENOG4105CJT Mannose-1-phosphate guanylyltransferase HVZ20_14255 ENOG4105EGZ biosynthesis protein HVZ20_14275 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) HVZ20_14280 ENOG4105C1B dTDP-glucose 4-6-dehydratase HVZ20_14285 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase HVZ20_14290 ENOG4105G1A colanic acid biosynthesis protein HVZ20_14295 ENOG4107T8Q Glycosyl transferase (Group 1 HVZ20_14300 ENOG4105C74 pyruvyl transferase HVZ20_14305 ENOG4105PSV Polysaccharide Biosynthesis Protein HVZ20_14310 ENOG4105D3Q Sugar transferase HVZ20_14315 ENOG4107QKV phosphomannomutase HVZ20_14320 ENOG4105CJT Mannose-1-phosphate guanylyltransferase HVZ20_14325 ENOG4106CD9 glycosyl transferase group 1 HVZ20_14330 ENOG4105FGF GDP-mannose mannosyl hydrolase HVZ20_14335 ENOG4105C30 Nad-dependent epimerase dehydratase HVZ20_14340 ENOG4105C0K Gdp-mannose 4,6-dehydratase HVZ20_14345 ENOG4108Z90 colanic acid biosynthesis acetyltransferase wcaF HVZ20_14360 ENOG4108NYJ Colanic acid HVZ20_14365 ENOG4107RXY Glycosyl transferase HVZ20_14370 ENOG41068PY Colanic acid biosynthesis acetyltransferase wcaB HVZ20_14375 ENOG41090RK glycosyl transferase HVZ20_14380 ENOG4105D75 Capsular exopolysaccharide family HVZ20_14385 ENOG4105KJF protein tyrosine phosphatase HVZ20_14390 ENOG4105DAY polysaccharide export protein HVZ20_14400 ENOG4105EE5 Membrane protein terC HVZ20_14405 ENOG4108GAE asmA family HVZ20_14415 ENOG4105DBI uridine monophosphokinase HVZ20_14455 ENOG4108R1E Serine threonine protein phosphatase 1 HVZ20_14495 ENOG4108I1J Integrase HVZ20_14520 ENOG4105EB3 Histidine kinase HVZ20_14525 ENOG4105E3W Two component transcriptional regulator (Winged helix family HVZ20_14530 ENOG4105KWI UPF0339 protein HVZ20_14535 ENOG4105CFP Peptidase U32 HVZ20_14540 ENOG41076Z6 Uncharacterized protein yegR HVZ20_14555 ENOG4107WTH Galactitol-1-phosphate dehydrogenase HVZ20_14560 ENOG4105DT3 PTS system, galactitol-specific IIc component HVZ20_14565 ENOG41090UW PTS System HVZ20_14570 ENOG41082GB PTS system galactitol-specific transporter subunit IIA HVZ20_14585 ENOG4105EIE fructose-bisphosphate aldolase HVZ20_14590 ENOG4105EAA nucleoside HVZ20_14595 ENOG4108KD5 ADP-ribosylation crystallin J1 HVZ20_14600 ENOG4108TFM Kinase, PfkB family HVZ20_14605 ENOG4105FDP GntR family transcriptional regulator HVZ20_14610 ENOG4108UQ1 hydrolase, family 25 HVZ20_14615 ENOG4105DWF phosphomethylpyrimidine kinase HVZ20_14620 ENOG4105C4U 4-methyl-5-beta-hydroxyethylthiazole kinase HVZ20_14630 ENOG41061MD high-affinity nickel-transporter HVZ20_14635 ENOG4108Z1S Influences nickel and cobalt homeostasis. May act by modulating RcnA-mediated export of these ions to avoid excess efflux. Not involved in nickel import and does not bind nickel or cobalt ions directly HVZ20_14645 ENOG410662B Type-1 fimbrial protein HVZ20_14655 ENOG4108MQF Chaperone HVZ20_14665 ENOG4105D1F ATP-binding protein HVZ20_14675 ENOG4108KDT Molybdate metabolism regulator HVZ20_14680 ENOG4108KDT Molybdate metabolism regulator HVZ20_14695 ENOG4105KKX ATPase associated with various cellular activities aaa_5 HVZ20_14700 ENOG4105RD5 HVZ20_14705 ENOG4105DEG Vwa containing coxe family protein HVZ20_14710 ENOG410903U zinc ion binding HVZ20_14715 ENOG4108YCW (LipO)protein HVZ20_14720 ENOG4108W15 Protein of unknown function (DUF1456) HVZ20_14725 ENOG4108NEV two component transcriptional regulator, LytTR family HVZ20_14730 ENOG4108HRK Histidine kinase HVZ20_14735 ENOG4108XDN Transcriptional regulator HVZ20_14745 ENOG4105WJV Binding-protein-dependent transport systems, inner membrane component HVZ20_14750 ENOG4108IJ8 ABC transporter HVZ20_14755 ENOG4107T5X Binding-protein-dependent transport systems, inner membrane component HVZ20_14760 ENOG4107SI7 Substrate-binding region of abc-type glycine betaine transport system HVZ20_14765 ENOG4107QK4 glycoside hydrolase, family 3 domain protein HVZ20_14770 ENOG4105CXG d-lactate dehydrogenase HVZ20_14775 ENOG41061WM D-Alanyl-D-Alanine HVZ20_14780 ENOG41069YE inner membrane protein yohC HVZ20_14785 ENOG4105KHU inner membrane protein YohD HVZ20_14790 ENOG4105H9W Short-chain dehydrogenase reductase Sdr HVZ20_14795 ENOG4105ETP RND efflux system, outer membrane lipoprotein HVZ20_14805 ENOG4105FBT Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity) HVZ20_14815 ENOG41067MG lrgb family HVZ20_14825 ENOG4107GZ4 SanA protein HVZ20_14830 ENOG4105Y9N Membrane HVZ20_14835 ENOG4105BZ8 glutamate synthase HVZ20_14840 ENOG4107SJI Dehydrogenase HVZ20_14845 ENOG4108HWV )-transporter HVZ20_14850 ENOG4105C2J ABC transporter HVZ20_14855 ENOG4105EMA Periplasmic binding protein LacI transcriptional regulator HVZ20_14860 ENOG41060NJ transcriptional regulator HVZ20_14865 ENOG4105DHF Membrane HVZ20_14875 ENOG4105C4W S-formylglutathione hydrolase HVZ20_14880 ENOG4105D05 Receptor HVZ20_14885 ENOG4108IQI permease HVZ20_14890 ENOG4105DUM transcriptional regulator, lysR family HVZ20_14895 ENOG4105HMI Membrane HVZ20_14905 ENOG4105DD7 kinase (PfkB family HVZ20_14920 ENOG4108Y4K DNA-binding transcriptional activator HVZ20_14925 ENOG4105D9N nucleoside HVZ20_14930 ENOG4105D53 Catalyzes the hydrolysis of pseudouridine 5'-phosphate (PsiMP) to ribose 5-phosphate and uracil (By similarity) HVZ20_14935 ENOG4105DD7 kinase (PfkB family HVZ20_14940 ENOG4105DM4 PTS System HVZ20_14945 ENOG4105DE4 1-phosphofructokinase HVZ20_14950 ENOG4105DTZ bifunctional PTS system fructose-specific transporter subunit IIA HPr protein HVZ20_14955 ENOG4105S8Q sugar efflux transporter HVZ20_14960 ENOG4105KRS Proteinase inhibitor HVZ20_14970 ENOG4105DEI Mannitol dehydrogenase HVZ20_14975 ENOG4105CKI cobalamin synthesis protein HVZ20_14980 ENOG41076MN Phosphoesterase, PA-phosphatase related HVZ20_14985 ENOG4107TT5 NLP P60 protein HVZ20_14990 ENOG4105CXC rtn protein HVZ20_14995 ENOG4105E43 Extracellular solute-binding protein, family 5 HVZ20_15000 ENOG4108I5X binding-protein-dependent transport systems inner membrane Component HVZ20_15005 ENOG4108IYQ Binding-protein-dependent transport systems inner membrane component HVZ20_15010 ENOG4108JQ5 ABC transporter HVZ20_15015 ENOG4105HG6 HVZ20_15020 ENOG4105C2C drug resistance transporter, Bcr CflA HVZ20_15025 ENOG4105I08 Pseudouridine synthase HVZ20_15030 ENOG4105CFI type iii restriction protein res subunit HVZ20_15050 ENOG4105E68 Sulfatase HVZ20_15060 ENOG4108MGN ATP-binding component of a transport system HVZ20_15065 ENOG4108MGN ATP-binding component of a transport system HVZ20_15070 ENOG4105WH1 Two component transcriptional regulator luxr family HVZ20_15075 ENOG4105KWW Biogenesis protein HVZ20_15080 ENOG4107QX9 Thiol disulfide interChange protein HVZ20_15085 ENOG4105DA4 cytochrome c-type biogenesis protein HVZ20_15095 ENOG4105X3C heme exporter protein HVZ20_15100 ENOG41060IM Heme exporter protein HVZ20_15105 ENOG4105CA5 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes (By similarity) HVZ20_15115 ENOG4105CUW cytochrome C-TYPE protein HVZ20_15120 ENOG4108ZMS Electron transfer subunit of the periplasmic nitrate reductase complex NapAB (By similarity) HVZ20_15125 ENOG4105GXZ Ferredoxin-type protein NapH HVZ20_15130 ENOG4108BGM Quinol dehydrogenase periplasmic component HVZ20_15140 ENOG41061Q0 Assembly protein for periplasmic nitrate reductase HVZ20_15145 ENOG4108ZNS ferredoxin-type protein NapF HVZ20_15155 ENOG4105DWT malate dehydrogenase (quinone) HVZ20_15160 ENOG4105IBP Cyclic peptide transporter HVZ20_15170 ENOG4108SER Transposase HVZ20_15180 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) HVZ20_15185 ENOG4105CJ2 (LipO)protein HVZ20_15190 ENOG4105FCK Membrane HVZ20_15195 ENOG4105E3G Phosphotransfer intermediate protein in two-component regulatory system with RcsBC HVZ20_15200 ENOG41068CG regulatoR HVZ20_15205 ENOG4105BZU Histidine kinase HVZ20_15210 ENOG4105BZU Histidine kinase HVZ20_15215 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family HVZ20_15220 ENOG4107QP7 CoA-transferase subunit A HVZ20_15240 ENOG4105CRW Short chain fatty acid transporter HVZ20_15245 ENOG4105CHU acetyl-coa acetyltransferase HVZ20_15250 ENOG4105EDV vault protein HVZ20_15255 ENOG41081SK signal peptide protein HVZ20_15260 ENOG4107S52 alpha-2-macroglobulin domain protein HVZ20_15265 ENOG4108QJJ Protein of unknown function (DUF1175) HVZ20_15270 ENOG4107FKF Uncharacterized protein conserved in bacteria (DUF2138) HVZ20_15275 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HVZ20_15300 ENOG4107GHC outer membrane autotransporter HVZ20_15305 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HVZ20_15310 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HVZ20_15315 ENOG4105XPH Ferredoxin HVZ20_15320 ENOG4105FQR PH-inducible protein involved in stress response HVZ20_15325 ENOG4106MZZ glycerophosphoryl diester phosphodiesterase HVZ20_15330 ENOG4105CXY transporter HVZ20_15335 ENOG4107R5Y anaerobic glycerol-3-phosphate dehydrogenase, subunit A HVZ20_15345 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) HVZ20_15350 ENOG4105DNE Transposase HVZ20_15360 ENOG4105CSP Major Facilitator Superfamily HVZ20_15365 ENOG4105CXK mandelate racemase muconate lactonizing HVZ20_15370 ENOG4107258 Transcriptional regulator HVZ20_15375 ENOG4108EWA cinA-like protein HVZ20_15380 ENOG4108UII YfaZ family HVZ20_15415 ENOG4105SA9 Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity) HVZ20_15430 ENOG4106GZG polymyxin resistance protein B HVZ20_15435 ENOG4105CEY Amp-dependent synthetase and ligase HVZ20_15445 ENOG4108IPT Naphthoate synthase HVZ20_15460 ENOG4105E4F Isochorismate synthase HVZ20_15465 ENOG4105TNS Conserved Protein HVZ20_15470 ENOG4107YB6 acetyltransferase, (GNAT) family HVZ20_15480 ENOG4105Z6G Protease that can act as an efficient and specific deubiquitinating enzyme in vitro. Does not possess desumoylating and deneddylating activities. The physiological substrate is HVZ20_15490 ENOG4105GDX Domain of unknown function (DUF1877) HVZ20_15500 ENOG4105C8S subunit m HVZ20_15505 ENOG4105D65 subunit l HVZ20_15515 ENOG4107UFS subunit j HVZ20_15530 ENOG4108IEH NADH dehydrogenase subunit g HVZ20_15535 ENOG4107QIZ NADH dehydrogenase HVZ20_15540 ENOG4105GKE subunit e HVZ20_15560 ENOG4107NQ8 LysR family Transcriptional regulator HVZ20_15565 ENOG4105CHM Aminotransferase HVZ20_15575 ENOG4107QWE )-transporter HVZ20_15580 ENOG4105EVE HAD-superfamily hydrolase subfamily IA variant 3 HVZ20_15595 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) HVZ20_15600 ENOG4105C6K Malic enzyme HVZ20_15605 ENOG4105CSX c4-dicarboxylate anaerobic carrier HVZ20_15610 ENOG4105PTV Nudix Hydrolase HVZ20_15615 ENOG4108RE9 Phosphodiesterase HVZ20_15620 ENOG4108SHQ Glutathione S-transferase HVZ20_15625 ENOG4105CYM Glutathione S-transferase HVZ20_15630 ENOG4105KKP D-erythro-7,8-dihydroneopterin triphosphate 2'-epimerase HVZ20_15635 ENOG4105ECP epimerase HVZ20_15640 ENOG4105DNE Transposase HVZ20_15645 ENOG4108JEH abc transporter atp-binding protein HVZ20_15650 ENOG4106YG3 ABC transporter HVZ20_15655 ENOG4105DSP amino acid AbC transporter HVZ20_15660 ENOG4105E89 ABC transporter HVZ20_15665 ENOG4105E89 ABC transporter HVZ20_15670 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase HVZ20_15675 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase HVZ20_15680 ENOG4105E96 Colicin v production protein HVZ20_15685 ENOG4108S3P Sporulation domain protein HVZ20_15690 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase HVZ20_15700 ENOG4105DQR SNARE associated Golgi HVZ20_15710 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) HVZ20_15720 ENOG4106WZ1 flagella biosynthesis regulator HVZ20_15725 ENOG4105F9N Major Facilitator Superfamily HVZ20_15730 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) HVZ20_15740 ENOG4105MH2 YfcL protein HVZ20_15745 ENOG4108BPE -transporting atpase HVZ20_15750 ENOG4105EJ9 Membrane HVZ20_15765 ENOG4105C76 Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity) HVZ20_15780 ENOG4105US4 fimbrial-like protein yfcP HVZ20_15785 ENOG4105UGQ Fimbrial HVZ20_15790 ENOG4105NEV Fimbrial HVZ20_15795 ENOG4108FZ9 Chaperone HVZ20_15800 ENOG4106PG1 outer membrane usher protein HVZ20_15810 ENOG4108BY2 phosphohistidine phosphatase HVZ20_15825 ENOG4105KZW UPF0381 protein HVZ20_15830 ENOG4105CKF membrane protein involved in aromatic hydrocarbon degradation HVZ20_15835 ENOG410903C (LipO)protein HVZ20_15840 ENOG4105S64 Formate nitrite transporter HVZ20_15850 ENOG4105DFP Integrase HVZ20_15960 ENOG4105SZK Rz endopeptidase from lambdoid prophage DLP12 HVZ20_15980 ENOG4108R1E Serine threonine protein phosphatase 1 HVZ20_16025 ENOG4105NY2 NinB protein HVZ20_16040 ENOG4105CDU Replicative dna helicase HVZ20_16100 ENOG4105VIZ double-strand break repair protein HVZ20_16105 ENOG4108UUM single-stranded DNA-binding protein HVZ20_16130 ENOG41077V0 CPS-53 (KpLE1) prophage HVZ20_16170 ENOG4105U0F oligosaccharide H symporter, major facilitator superfamily (MFS) HVZ20_16175 ENOG4105D7K pfkb domain protein HVZ20_16180 ENOG4108HKT sucrose-6-phosphate hydrolase HVZ20_16185 ENOG4106NDP Transcriptional regulator HVZ20_16215 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F HVZ20_16220 ENOG4108N2Y auxin Efflux HVZ20_16225 ENOG4105CFN oxalyl-CoA decarboxylase HVZ20_16235 ENOG4108V08 YfdX protein HVZ20_16245 ENOG4105W9M Membrane HVZ20_16250 ENOG4105D1S lipid A biosynthesis HVZ20_16260 ENOG4105CHM Aminotransferase HVZ20_16265 ENOG4108HRK Histidine kinase HVZ20_16270 ENOG4105DY9 regulatoR HVZ20_16275 ENOG4108CIP transcriptional regulator HVZ20_16280 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) HVZ20_16285 ENOG4105CN9 Peptidase m42 family protein HVZ20_16290 ENOG4105DC7 peptidase M24 HVZ20_16295 ENOG410863U PTS System HVZ20_16300 ENOG4105R6B The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane (By similarity) HVZ20_16315 ENOG4109076 Conserved Protein HVZ20_16325 ENOG4105D9N nucleoside HVZ20_16330 ENOG4108SER Transposase HVZ20_16335 ENOG4108KMM Diguanylate cyclase HVZ20_16350 ENOG4105HZG regulatoR HVZ20_16355 ENOG4105GXM Putative transcription regulator (DUF1323) HVZ20_16370 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) HVZ20_16395 ENOG4105CN8 Transcriptional regulator HVZ20_16400 ENOG4105EAA nucleoside HVZ20_16405 ENOG4107U5R The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity) HVZ20_16420 ENOG4105DHU Bile acid HVZ20_16425 ENOG4105VRT cytoplasmic protein HVZ20_16445 ENOG4105C6T cysteine synthase HVZ20_16455 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) HVZ20_16460 ENOG4105C5Y PTS System HVZ20_16470 ENOG4105M0Y HVZ20_16475 ENOG4105C6T cysteine synthase HVZ20_16480 ENOG4108IJ6 ABC transporter HVZ20_16485 ENOG4105ECW sulfate abc transporter HVZ20_16490 ENOG4108I5D sulfate abc transporter HVZ20_16495 ENOG4108J2H Sulfate ABC transporter periplasmic sulfate-binding protein HVZ20_16500 ENOG4105I7Z Short-chain dehydrogenase reductase Sdr HVZ20_16505 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate HVZ20_16510 ENOG4105C5Y PTS System HVZ20_16515 ENOG4105EZR dyp-type peroxidase family protein HVZ20_16520 ENOG4105E7K (LipO)protein HVZ20_16525 ENOG4105QZU Inner membrane protein YfeZ HVZ20_16535 ENOG4108KNB n-acetylmuramoyl-l-alanine amidase HVZ20_16550 ENOG4105C0D helicase HVZ20_16555 ENOG4107H8F HVZ20_16565 ENOG4108K3Z AraC family transcriptional regulator HVZ20_16570 ENOG4108X49 Ethanolamine utilization protein EutK HVZ20_16575 ENOG4106D67 ethanolamine utilization protein HVZ20_16585 ENOG4105CPD ethanolamine ammonia-lyase HVZ20_16590 ENOG4105DYY Reactivating factor for ethanolamine ammonia lyase HVZ20_16610 ENOG4108EKI Dehydrogenase HVZ20_16615 ENOG4105WVM ethanolamine utilization protein EutN carboxysome structural protein Ccml HVZ20_16620 ENOG4105KNY Microcompartments protein HVZ20_16625 ENOG4107WUY phosphate acetyltransferase HVZ20_16630 ENOG4108PFF ethanolamine utilization cobalamin adenosyltransferase HVZ20_16635 ENOG4105NDK ethanolamine utilization protein HVZ20_16640 ENOG4106S4J ethanolamine utilization protein EutP HVZ20_16645 ENOG4108VJN May be involved in the formation of a specific microcompartment in the cell in which the metabolism of potentially toxic by-products takes place HVZ20_16650 ENOG4105C6K Malic enzyme HVZ20_16655 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) HVZ20_16660 ENOG4105CV1 Transketolase (EC 2.2.1.1) HVZ20_16665 ENOG4108PVD exported protein HVZ20_16675 ENOG4105BZ8 glutamate synthase HVZ20_16680 ENOG4105BZU Histidine kinase HVZ20_16695 ENOG4105BZS acriflavin resistance protein HVZ20_16705 ENOG4105KUZ arsenate reductase HVZ20_16720 ENOG4106KED esterase YpfH HVZ20_16730 ENOG4105CGZ zinc metallopeptidase HVZ20_16740 ENOG4107EG0 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) HVZ20_16750 ENOG4105RH4 Glycine cleavage system transcriptional repressor HVZ20_16755 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen HVZ20_16760 ENOG4105C02 permease HVZ20_16765 ENOG4105ERG peptidase m48, ste24p HVZ20_16770 ENOG4105K89 arsenate reductase HVZ20_16775 ENOG4108KZ1 Mediates the interaction of DNA replication inititator protein DnaA with DNA polymerase subunit beta sliding clamp (dnaN). Stimulates hydrolysis of ATP-DnaA to ADP-DnaA, rendering DnaA inactive for reinititation, a process called regulatory inhibition of DnaA or RIDA (By similarity) HVZ20_16780 ENOG4105C2W permease HVZ20_16795 ENOG4108V3E phosphoribosylglycinamide formyltransferase HVZ20_16800 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) HVZ20_16805 ENOG4105C9X ppx gppa phosphatase HVZ20_16820 ENOG41062G3 Protein of unknown function (DUF2633) HVZ20_16825 ENOG4108ZMA Outer membrane lipoprotein HVZ20_16830 ENOG41066DY Membrane HVZ20_16840 ENOG4105NVB glycoside hydrolase, family 19 HVZ20_16980 ENOG4108TFU terminase (Small subunit) HVZ20_17000 ENOG41077V0 CPS-53 (KpLE1) prophage HVZ20_17055 ENOG4108PNI recT protein HVZ20_17075 ENOG4108R1E Serine threonine protein phosphatase 1 HVZ20_17090 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) HVZ20_17100 ENOG4105VPD cellular component movement HVZ20_17140 ENOG4105N21 Membrane HVZ20_17170 ENOG4108JQB penicillin-binding protein 1C HVZ20_17175 ENOG4105DN3 alpha-2-macroglobulin domain protein HVZ20_17180 ENOG4105KHC sulfurtransferase HVZ20_17185 ENOG4105YYA enhanced serine sensitivity protein SseB HVZ20_17195 ENOG4105WVQ Fe-S assembly protein IscX HVZ20_17200 ENOG4108ZIT Ferredoxin, 2FE-2S HVZ20_17220 ENOG4107XTC May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins HVZ20_17240 ENOG4105ECY inositol monophosphatase HVZ20_17245 ENOG4107XM9 (LipO)protein HVZ20_17250 ENOG4108MN2 Stationary phase inducible protein CsiE HVZ20_17255 ENOG4105D8G Major Facilitator superfamily HVZ20_17260 ENOG4108SB3 DoxX Family HVZ20_17265 ENOG4108ZKT aldose 1-epimerase HVZ20_17270 ENOG4105CPQ Dehydrogenase HVZ20_17275 ENOG4105CNN ABC, transporter HVZ20_17280 ENOG4108F37 ATP-binding component of a transport system HVZ20_17285 ENOG4105FCA ABC transporter periplasmic-binding protein YphF HVZ20_17290 ENOG4107HQ7 repeat protein HVZ20_17295 ENOG4108NZE NAGC-like transcriptional regulator HVZ20_17305 ENOG4108EGH Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) HVZ20_17315 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family HVZ20_17320 ENOG4108SKK alpha helix protein HVZ20_17325 ENOG4107WP9 Histidine kinase HVZ20_17330 ENOG4108ETH Formylglycinamide ribotide synthetase HVZ20_17335 ENOG4105CHQ Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella (By similarity) HVZ20_17340 ENOG4108Z6B deaminase HVZ20_17345 ENOG4105HYY HAD superfamily (Subfamily IF) hydrolase, YfhB HVZ20_17350 ENOG4106G6Q Transcriptional regulator HVZ20_17355 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding HVZ20_17370 ENOG4105CSZ Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity) HVZ20_17390 ENOG4105C3F Signal peptidase i HVZ20_17400 ENOG4105WMJ Positive regulator of sigma E, RseC MucC HVZ20_17405 ENOG4105VQK sigma E regulatory protein, MucB RseB HVZ20_17410 ENOG41069PW sigma-e factor negative regulatory protein HVZ20_17415 ENOG4105EMN RNA polymerase sigma factor HVZ20_17425 ENOG4108IYU L-aspartate oxidase HVZ20_17435 ENOG4105C1J atp-dependent rna helicase HVZ20_17440 ENOG41090KR LysR family transcriptional Regulator HVZ20_17460 ENOG4105EIB trna rrna methyltransferase HVZ20_17465 ENOG4105K63 Thioredoxin HVZ20_17470 ENOG4106IUH DTW domain containing protein HVZ20_17475 ENOG4105CD5 CoA-binding domain protein HVZ20_17480 ENOG4105JIM Phosphatidylserine synthase HVZ20_17485 ENOG4105T42 (LipO)protein HVZ20_17490 ENOG4105CSH Transporter HVZ20_17520 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit HVZ20_17525 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase HVZ20_17530 ENOG4105C34 Pseudouridine synthase HVZ20_17535 ENOG4106SNF Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane HVZ20_17550 ENOG4108WPH sigma 54 modulation protein ribosomal protein S30EA HVZ20_17560 ENOG4105CQC Prephenate dehydratase HVZ20_17565 ENOG4105EHE chorismate mutase- prephenate dehydrogenase HVZ20_17570 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) HVZ20_17575 ENOG4105QP9 Protein of unknown function (DUF2799) HVZ20_17580 ENOG4108WS1 HVZ20_17585 ENOG4108KHX Diguanylate cyclase HVZ20_17590 ENOG41090EK ompa motb domain protein HVZ20_17595 ENOG4108RS6 transposase HVZ20_17625 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY HVZ20_17630 ENOG4106KVJ cytochrome C assembly protein HVZ20_17635 ENOG4108JU6 CBS domain protein HVZ20_17650 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) HVZ20_17655 ENOG4105YRI Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) HVZ20_17665 ENOG4108Z1B Cyclase dehydrase HVZ20_17750 ENOG4105E54 alpha-amylase HVZ20_17760 ENOG4105D5U fad dependent oxidoreductase HVZ20_17765 ENOG4105C26 Dehydrogenase HVZ20_17770 ENOG4108JPW Aminotransferase HVZ20_17775 ENOG4105C85 amino acid HVZ20_17780 ENOG4108PVQ transcriptional regulator HVZ20_17785 ENOG4109066 lysm domain bon superfamily protein HVZ20_17790 ENOG4105VPI YqaE family transport protein HVZ20_17795 ENOG41080HT Transcriptional regulator, arsr family HVZ20_17800 ENOG4108V62 Rhodanese domain protein HVZ20_17805 ENOG4108X73 DNA- binding protein HVZ20_17810 ENOG4108RNS Exports L-alanine (By similarity) HVZ20_17815 ENOG4108WMJ Protein of unknown function (DUF2002) HVZ20_17820 ENOG4108ZQZ Bacterial protein of unknown function (DUF883) HVZ20_17830 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) HVZ20_17835 ENOG4105WAZ (Glutaredoxin-like protein) NrdH HVZ20_17845 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HVZ20_17865 ENOG4108IJ7 Glycine betaine HVZ20_17870 ENOG4108HQS Glycine betaine HVZ20_17875 ENOG4105GIJ Glycine betaine HVZ20_17880 ENOG4105EQ0 Major Facilitator superfamily HVZ20_17885 ENOG4108UMN azlc family HVZ20_17890 ENOG4105ZED uncharacterized protein ygaH HVZ20_17895 ENOG4105NTK Transcriptional repressor Mpra HVZ20_17900 ENOG4105CW7 secretion protein, HlyD family HVZ20_17905 ENOG4105C0R drug resistance transporter emrb qaca subfamily HVZ20_17930 ENOG4105W39 Membrane HVZ20_17935 ENOG4107VXZ Hydrolase HVZ20_17960 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) HVZ20_17980 ENOG4107TH8 cina domain protein HVZ20_17985 ENOG4105CVE Lytic murein transglycosylase HVZ20_17990 ENOG4105C2X Arabinose 5-phosphate isomerase HVZ20_17995 ENOG4108JUA Transcriptional regulator HVZ20_18010 ENOG4105C8H hydrogenase maturation protein Hypf HVZ20_18015 ENOG4108RC0 Electron transport protein HVZ20_18020 ENOG4105DDV Transcriptional regulator (LacI family HVZ20_18025 ENOG4105C5Y PTS System HVZ20_18030 ENOG4105CS2 ec 3.2.1.21 HVZ20_18035 ENOG4108Z3N Transcriptional regulator HVZ20_18040 ENOG4105RVE Uncharacterized protein conserved in bacteria (DUF2136) HVZ20_18045 ENOG4108MG9 hydrogenase 3 maturation protease HVZ20_18050 ENOG4105I6X formate hydrogenlyase maturation HVZ20_18055 ENOG4105C47 NADH ubiquinone oxidoreductase 20 kda subunit HVZ20_18060 ENOG4108RG7 formate hydrogenlyase complex iron-sulfur subunit HVZ20_18065 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HVZ20_18070 ENOG4107TDF Formate hydrogenlyase subunit 4 HVZ20_18075 ENOG4107R30 NADH dehydrogenase HVZ20_18080 ENOG4108MFN small subunit of hydrogenase-3, iron-sulfur protein (part of formate hydrogenlyase (FHL) complex) HVZ20_18085 ENOG4108VRC Formate hydrogenlyase regulatory protein hycA HVZ20_18090 ENOG410816D Probably plays a role in a hydrogenase nickel cofactor insertion step (By similarity) HVZ20_18095 ENOG4107RSS Hydrogenase accessory protein HypB HVZ20_18100 ENOG41083WG hydrogenase assembly chaperone HVZ20_18105 ENOG4105CQS hydrogenase expression formation protein HypD HVZ20_18110 ENOG4105C45 hydrogenase expression formation protein (HypE) HVZ20_18115 ENOG4108JUA Transcriptional regulator HVZ20_18125 ENOG4105VXR cytoplasmic protein HVZ20_18130 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) HVZ20_18135 ENOG4105MEW serine threonine protein phosphatase HVZ20_18140 ENOG4105MVE transcriptional regulator HVZ20_18150 ENOG4105G63 Type III effector Hrp-dependent HVZ20_18155 ENOG4105FB2 class II Aldolase HVZ20_18160 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) HVZ20_18165 ENOG4105C6Z Gluconate HVZ20_18170 ENOG4105KZM cytoplasmic protein HVZ20_18175 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) HVZ20_18180 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase HVZ20_18190 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HVZ20_18195 ENOG4108K5P (LipO)protein HVZ20_18230 ENOG4105N0Z inner membrane protein ygbE HVZ20_18250 ENOG4108MXK alkaline phosphatase isozyme conversion HVZ20_18255 ENOG4107635 Hok Gef family protein HVZ20_18280 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase HVZ20_18285 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase HVZ20_18290 ENOG4105WQV ferredoxin-like protein HVZ20_18295 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator HVZ20_18300 ENOG4105YBM electron transfer flavoprotein subunit ygcQ HVZ20_18305 ENOG4106IKH Electron transfer flavoprotein HVZ20_18310 ENOG4105C54 Major Facilitator superfamily HVZ20_18315 ENOG4107R3A FAD linked oxidase domain protein HVZ20_18320 ENOG4105CHR reductase HVZ20_18325 ENOG4108ITV Inner membrane protein yqcE HVZ20_18330 ENOG4108CWB sugar kinase ygcE HVZ20_18355 ENOG4105WBN Transcriptional regulator (LacI family HVZ20_18360 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) HVZ20_18370 ENOG4105HA9 of methanol dehydrogenase type HVZ20_18390 ENOG4105DXN mazG family HVZ20_18395 ENOG4105MZG transcriptional modulator of maze toxin, mazf HVZ20_18400 ENOG4106A2Z transcriptional regulator antitoxin, MazE HVZ20_18405 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) HVZ20_18415 ENOG4105BZU Histidine kinase HVZ20_18420 ENOG4105EQX glucarate dehydratase HVZ20_18425 ENOG4105EQX glucarate dehydratase HVZ20_18430 ENOG4105DJB Major Facilitator Superfamily HVZ20_18435 ENOG4105QDK Flavodoxin HVZ20_18440 ENOG4105DR9 pseudouridine synthase HVZ20_18445 ENOG4105WP7 tRNA pseudouridine synthase C HVZ20_18460 ENOG4105EWT decarboxylase family HVZ20_18465 ENOG4105C44 Serine transporter HVZ20_18470 ENOG4105EJQ L-serine dehydratase HVZ20_18480 ENOG4105C0A alcohol dehydrogenase HVZ20_18485 ENOG4107W7X Aldolase HVZ20_18510 ENOG4105EHF Converts the aldose L-fucose into the corresponding ketose L-fuculose (By similarity) HVZ20_18515 ENOG4105CMG Carbohydrate kinase HVZ20_18525 ENOG4107EDW L-fucose operon activator HVZ20_18535 ENOG4105M08 Membrane HVZ20_18540 ENOG4105ETT transcriptional Regulator, LysR family HVZ20_18545 ENOG4105M5B (LipO)protein HVZ20_18550 ENOG4105C9B Cysteine desulfurase HVZ20_18555 ENOG4105P9C Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity) HVZ20_18560 ENOG4105CUZ uba thif-type nad fad binding protein HVZ20_18565 ENOG4105CA3 membrane-bound lytic murein transglycosylase HVZ20_18590 ENOG4105C2X Arabinose 5-phosphate isomerase HVZ20_18595 ENOG4105C87 Aminotransferase class I and II HVZ20_18600 ENOG4105CI1 PTS System HVZ20_18610 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase HVZ20_18615 ENOG4108EKC n-acetylglutamate synthase HVZ20_18620 ENOG4107QYX exodeoxyribonuclease v alpha HVZ20_18625 ENOG4107QKA exodeoxyribonuclease V beta HVZ20_18630 ENOG4107QXK peptidase HVZ20_18635 ENOG4105DSY exodeoxyribonuclease V, gamma HVZ20_18640 ENOG4105RVB Prepilin peptidase dependent protein c HVZ20_18645 ENOG4105SEN Protein of unknown function (DUF2509) HVZ20_18650 ENOG4105JCS prepilin peptidase dependent protein HVZ20_18655 ENOG4105IPU prepilin peptidase dependent protein A HVZ20_18670 ENOG4108HRM phosphoenolpyruvate--protein phosphotransferase HVZ20_18685 ENOG4105EE5 Membrane protein terC HVZ20_18695 ENOG4105SUV lipoprotein YgdR HVZ20_18700 ENOG4105CPC Aldo Keto reductase HVZ20_18705 ENOG4107S74 Lysophospholipid transporter LplT HVZ20_18715 ENOG41060NJ transcriptional regulator HVZ20_18725 ENOG4105RQF LysR family Transcriptional regulator HVZ20_18735 ENOG4107QNK )-transporter HVZ20_18740 ENOG4105CHR reductase HVZ20_18750 ENOG4105CHU acetyl-coa acetyltransferase HVZ20_18755 ENOG4108MHD transport protein HVZ20_18765 ENOG4108K5P (LipO)protein HVZ20_18770 ENOG4105C7W Xanthine dehydrogenase HVZ20_18775 ENOG4108HR6 Dehydrogenase HVZ20_18780 ENOG4108UTP (2Fe-2S)-binding domain protein HVZ20_18785 ENOG4108JUB Transcriptional regulator HVZ20_18790 ENOG4105IW6 Carbamoyltransferase HVZ20_18795 ENOG4107RCH Diaminopropionate ammonia-lyase HVZ20_18800 ENOG4107S4Y M20 DapE family protein YgeY HVZ20_18810 ENOG4105C5B carbamate kinase HVZ20_18815 ENOG4107P0T Selenium-dependent molybdenum hydroxylase system protein, YqeB family HVZ20_18820 ENOG4105MJ6 selenium-dependent hydroxylase accessory protein YqeC HVZ20_18825 ENOG4105MFX 4-diphosphocytidyl-2c-methyl-d-erythritol synthase HVZ20_18830 ENOG4105BZ8 glutamate synthase HVZ20_18835 ENOG4107UUR Chlorohydrolase aminohydrolase HVZ20_18840 ENOG410873Y FAD binding domain in molybdopterin dehydrogenase HVZ20_18845 ENOG4105C7W Xanthine dehydrogenase HVZ20_18850 ENOG4105C2W permease HVZ20_18860 ENOG4107QUY Guanine deaminase HVZ20_18865 ENOG4105C7N Xanthine uracil vitamin C permease HVZ20_18870 ENOG4108R8B oxidoreductase Fe-S subunit HVZ20_18875 ENOG4105BZ8 glutamate synthase HVZ20_18880 ENOG4105C2W permease HVZ20_18900 ENOG4105CRK lysyL-tRNA synthetase HVZ20_18910 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) HVZ20_18915 ENOG4105T95 Thiol disulfide interChange protein HVZ20_18920 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HVZ20_18925 ENOG41071R3 Low-potential electron donor to a number of redox enzymes (By similarity) HVZ20_18930 ENOG4108YDB Toxic component of a toxin-antitoxin (TA) module. Overexpression leads to growth arrest after 5 hours, with initial elongation of cells, followed by swelling. The toxic effects are abrogated by coexpression with antitoxin CptB. Interacts with cytoskeletal proteins FtsZ and MreB HVZ20_18935 ENOG4105Y75 tpr repeat protein HVZ20_18945 ENOG4108UT2 hemolysin iii HVZ20_18955 ENOG4105CS2 ec 3.2.1.21 HVZ20_18980 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family HVZ20_18985 ENOG4105D0A hydroxylase HVZ20_18990 ENOG4107RAQ aminopeptidase HVZ20_19010 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase HVZ20_19020 ENOG4108JQ1 Dehydrogenase HVZ20_19040 ENOG4105D5P Methylmalonyl-coA mutase HVZ20_19050 ENOG4105MPN Membrane HVZ20_19055 ENOG4108ZUB Lysine exporter protein (Lyse ygga) HVZ20_19060 ENOG4105D64 Mechanosensitive ion channel HVZ20_19065 ENOG4105D2N Aldolase HVZ20_19080 ENOG4107Z1W Fructose transport system kinase HVZ20_19085 ENOG4108R4K DNA-binding, transcriptional regulator HVZ20_19095 ENOG4105DXH Alcohol dehydrogenase zinc-binding domain protein HVZ20_19100 ENOG4105CTS PTS system mannitol-specific HVZ20_19105 ENOG4108X7Y Mannitol-specific cryptic phosphotransferase enzyme iia HVZ20_19110 ENOG4105EPW hflc protein HVZ20_19115 ENOG4105CV1 Transketolase (EC 2.2.1.1) HVZ20_19120 ENOG4108K0D peptidase, M48 HVZ20_19135 ENOG4105DP5 Catalyzes the biosynthesis of agmatine from arginine (By similarity) HVZ20_19155 ENOG4107QNK )-transporter HVZ20_19165 ENOG4105RWS endonuclease I HVZ20_19170 ENOG4105QF0 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) HVZ20_19175 ENOG4105D7Z glutathione synthase HVZ20_19190 ENOG4105CZX twitching motility protein HVZ20_19195 ENOG4105DFA alanine racemase domain protein HVZ20_19200 ENOG4108VIA integral membrane protein HVZ20_19210 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) HVZ20_19215 ENOG4105CSA Coproporphyrinogen iii oxidase HVZ20_19225 ENOG4105HDK L-asparaginase HVZ20_19230 ENOG4105K33 Periplasmic Protein HVZ20_19235 ENOG41090ED Protein with unknown function (DUF469) HVZ20_19245 ENOG4105CEN a g-specific adenine glycosylase HVZ20_19260 ENOG4105EAA nucleoside HVZ20_19265 ENOG4105CXN decarboxylase HVZ20_19270 ENOG4108UQV Membrane HVZ20_19280 ENOG4105U1E general secretion pathway protein M HVZ20_19300 ENOG4105X5Z General secretion pathway protein I HVZ20_19310 ENOG4108VAU general secretion pathway protein G HVZ20_19315 ENOG4105D7Q type ii secretion system HVZ20_19320 ENOG4107QHF type ii secretion system protein e HVZ20_19330 ENOG4108XKW General secretion pathway protein C HVZ20_19335 ENOG410765S (LipO)protein HVZ20_19340 ENOG4105EHH Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue (By similarity) HVZ20_19345 ENOG4105F88 accessory colonization factor AcfD HVZ20_19350 ENOG4105DAA L-lactate HVZ20_19355 ENOG4107QP3 malate synthase g HVZ20_19360 ENOG4108ZJF Glcg protein HVZ20_19365 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) HVZ20_19370 ENOG4105EU8 FAD linked oxidase domain protein HVZ20_19375 ENOG4105CQB FAD linked oxidase domain protein HVZ20_19380 ENOG4108KWP DNA-binding transcriptional regulator GlcC HVZ20_19390 ENOG4107RCI amp-dependent synthetase and ligase HVZ20_19400 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) HVZ20_19405 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) HVZ20_19415 ENOG4108M8S permease YjgP YjgQ family protein HVZ20_19420 ENOG4108UUE Transcriptional regulator HVZ20_19430 ENOG4108S55 polysaccharide biosynthesis protein HVZ20_19435 ENOG4106FPV ATP-binding protein YghR HVZ20_19440 ENOG4108NDC ATP-binding protein yghS HVZ20_19445 ENOG4108GH0 ATP-binding protein yghT HVZ20_19450 ENOG4105CJ3 phosphate transporter HVZ20_19455 ENOG4106032 Glutathionylspermidine synthase HVZ20_19460 ENOG4105CYM Glutathione S-transferase HVZ20_19465 ENOG41082MF Hydrogenase assembly chaperone hypC hupF HVZ20_19470 ENOG4105WMM Probably plays a role in a hydrogenase nickel cofactor insertion step (By similarity) HVZ20_19475 ENOG4108WGS hydrogenase 2-specific chaperone HVZ20_19480 ENOG4108USZ hydrogenase HVZ20_19485 ENOG4105DPX Hydrogenase, large subunit HVZ20_19490 ENOG4105CJ5 hydrogenase 2 b cytochrome subunit HVZ20_19495 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein HVZ20_19500 ENOG4105E3S small subunit HVZ20_19505 ENOG410900S Protein of unknown function (DUF2623) HVZ20_19545 ENOG4105CYX Short-chain dehydrogenase reductase Sdr HVZ20_19550 ENOG4108ZZF transport protein (ExbD) HVZ20_19555 ENOG4105CWK Biopolymer transport protein, ExbB HVZ20_19560 ENOG4105C28 cystathionine HVZ20_19565 ENOG4108K81 inner membrane protein YghB HVZ20_19570 ENOG4105CF7 AraC family transcriptional regulator HVZ20_19575 ENOG4108I6A alcohol dehydrogenase HVZ20_19580 ENOG4105CV8 reductase HVZ20_19585 ENOG4105ZKC Conserved Protein HVZ20_19595 ENOG4105CCT upf0313 protein HVZ20_19600 ENOG4107TZ2 Cell division protein that is required for growth during stress conditions. May be involved in protecting or stabilizing the divisomal assembly under conditions of stress (By similarity) HVZ20_19605 ENOG4107S7E 1-acyl-sn-glycerol-3-phosphate acyltransferase HVZ20_19610 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HVZ20_19615 ENOG4108J59 Extracellular solute-binding protein, family 5 HVZ20_19620 ENOG4105F4I Transcriptional regulator HVZ20_19625 ENOG4105H4F exported protein HVZ20_19630 ENOG4105XJC Two component transcriptional regulator (Winged helix family HVZ20_19635 ENOG4105DHQ Histidine kinase HVZ20_19640 ENOG4105NF4 modulator of drug activity HVZ20_19645 ENOG4105VRH Antibiotic biosynthesis monooxygenase HVZ20_19650 ENOG4106KNT transcriptional regulator HVZ20_19660 ENOG4105EHG Permease protein HVZ20_19665 ENOG4105DQ5 transport system permease protein HVZ20_19670 ENOG4105E0A ABC, transporter HVZ20_19680 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HVZ20_19685 ENOG4105IPS esterase HVZ20_19690 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) HVZ20_19695 ENOG4108SX3 cytoplasmic protein HVZ20_19700 ENOG41087AY ADP-Ribose pyrophosphatase HVZ20_19705 ENOG4105DFG type I secretion outer membrane protein HVZ20_19715 ENOG4106032 Glutathionylspermidine synthase HVZ20_19720 ENOG4108MR7 Arylsulfotransferase HVZ20_19735 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b HVZ20_19750 ENOG4105H8W Fimbrial protein HVZ20_19770 ENOG4108TTM chaperone HVZ20_19775 ENOG4108MY7 Fimbrial HVZ20_19785 ENOG4105W0Z cytoplasmic protein HVZ20_19795 ENOG4105PV3 Inner membrane protein yqiJ HVZ20_19800 ENOG4107S78 Band 7 protein HVZ20_19820 ENOG4105I7R Adenylate cyclase HVZ20_19825 ENOG4106MWK domain protein HVZ20_19840 ENOG4107ZVW dihydroneopterin aldolase HVZ20_19850 ENOG4105EJC lysr family transcriptional regulator HVZ20_19855 ENOG4106DSS Tartrate dehydratase subunit alpha HVZ20_19860 ENOG4107GFK fumarate HVZ20_19865 ENOG4107QPK )-transporter HVZ20_19880 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) HVZ20_19885 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HVZ20_19925 ENOG4105MAW Antitoxin component of a toxin-antitoxin (TA) module. Labile antitoxin that counteracts the effect of the CbtA (YeeV) toxin. It does not bind to the cognate toxin but instead binds to MreB and FtsZ (the toxin targets), enhancing their polymerization by forming higher-order bundles HVZ20_19935 ENOG4108YGG dna repair protein HVZ20_19940 ENOG4105MFG Antirestriction protein HVZ20_19945 ENOG4106H6R UPF0380 protein HVZ20_19950 ENOG4105F4K antigen 43 HVZ20_19975 ENOG4105F2I Transposase HVZ20_19985 ENOG4108ZZK Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source (By similarity) HVZ20_19990 ENOG4107QR9 Iron-sulfur cluster binding protein HVZ20_19995 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) HVZ20_20000 ENOG4105CXG d-lactate dehydrogenase HVZ20_20015 ENOG4105EKQ RNA-directed DNA polymerase HVZ20_20035 ENOG4105D7K pfkb domain protein HVZ20_20050 ENOG4105C5Y PTS System HVZ20_20090 ENOG4105JXR Protein of unknown function (DUF3296) HVZ20_20095 ENOG410693A DNA-binding protein HVZ20_20125 ENOG4105Q26 Siderophore-interacting protein HVZ20_20130 ENOG4105NTW Transcriptional regulator HVZ20_20135 ENOG4107RHT methyl-accepting chemotaxis sensory transducer with Pas Pac sensor HVZ20_20145 ENOG4108Y51 tRNA-binding protein HVZ20_20150 ENOG4105CQ4 Transcriptional regulator HVZ20_20155 ENOG4105CNT hydrolase family 2 HVZ20_20160 ENOG4105FK9 beta-D-galactosidase beta subunit HVZ20_20165 ENOG4105E5D amino acid HVZ20_20170 ENOG4107W6W Conserved Protein HVZ20_20175 ENOG4107WCA isomerase HVZ20_20180 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HVZ20_20185 ENOG4108Z3N Transcriptional regulator HVZ20_20200 ENOG4108VKG metal-dependent hydrolase HVZ20_20205 ENOG4108UB4 uncharacterized protein ygjQ HVZ20_20210 ENOG4105EE0 oxidoreductase HVZ20_20215 ENOG4105DU1 integral membrane protein, terc HVZ20_20220 ENOG4107QV7 Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system) (By similarity) HVZ20_20225 ENOG4105P66 Membrane HVZ20_20230 ENOG4105CTX dehydratase HVZ20_20240 ENOG4105DPW Major facilitator superfamily MFS_1 HVZ20_20245 ENOG4107YCY Transcriptional regulator HVZ20_20250 ENOG4106W5V Membrane HVZ20_20255 ENOG4105IYR Modulates the activity of the EnvZ OmpR two-component regulatory system, probably by directly modulating EnvZ enzymatic activity and increasing stability of phosphorylated OmpR (By similarity) HVZ20_20260 ENOG4105WAY exported protein HVZ20_20265 ENOG4105NE1 Conserved Protein HVZ20_20270 ENOG41090KG Inner membrane protein YqjE HVZ20_20275 ENOG4105YJD HVZ20_20280 ENOG4108VBZ doxx family HVZ20_20285 ENOG4105CHF Glutathione S-transferase HVZ20_20290 ENOG4105KAF membrAne HVZ20_20295 ENOG4105CWB LysR family transcriptional Regulator HVZ20_20300 ENOG4108CNN domain protein HVZ20_20305 ENOG4106D80 Uncharacterized protein YhaL HVZ20_20315 ENOG4105C44 Serine transporter HVZ20_20320 ENOG4105EJQ L-serine dehydratase HVZ20_20325 ENOG4105KME endoribonuclease L-psp HVZ20_20330 ENOG4105C6N Formate acetyltransferase HVZ20_20345 ENOG4105C7B Threonine dehydratase HVZ20_20350 ENOG410811B TRANSCRIPTIONal HVZ20_20365 ENOG4105BZW Glycerate kinase HVZ20_20370 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase HVZ20_20380 ENOG4105DJB Major Facilitator Superfamily HVZ20_20385 ENOG4105CTX dehydratase HVZ20_20390 ENOG4105E98 transcriptional regulator DeoR family HVZ20_20400 ENOG4108RG5 PTS system N-acetylgalactosamine-specific transporter subunit IIB HVZ20_20410 ENOG4105F3R pts system mannose fructose sorbose family iid HVZ20_20415 ENOG4108YTN IIa component HVZ20_20420 ENOG4105CE4 GlcNAc 6-P deacetylase HVZ20_20425 ENOG4105E70 isomerase HVZ20_20435 ENOG4108UZY PTS System HVZ20_20445 ENOG4105ETZ PTS System HVZ20_20450 ENOG4105F3R pts system mannose fructose sorbose family iid HVZ20_20455 ENOG4106HBN Galactosamine-6-phosphate isomerase HVZ20_20460 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) HVZ20_20480 ENOG4105W4M Transport-associated protein HVZ20_20485 ENOG4107S21 permease HVZ20_20490 ENOG4105K4T epimerase HVZ20_20505 ENOG4108YYD acetyltransferase HVZ20_20525 ENOG4105DEN Luciferase family HVZ20_20530 ENOG4105CIC tryptophan-specific transport protein HVZ20_20535 ENOG4105C1J atp-dependent rna helicase HVZ20_20575 ENOG4105CHV Transcription elongation factor NusA HVZ20_20595 ENOG4105DIJ Phosphoethanolamine transferase HVZ20_20605 ENOG4105NTZ Preprotein translocase subunit SecG HVZ20_20615 ENOG4105EEI dihydropteroate synthase HVZ20_20620 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) HVZ20_20630 ENOG4105HBR Rna-binding protein HVZ20_20635 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) HVZ20_20640 ENOG4106HRJ d-alanyl-d-alanine carboxypeptidase HVZ20_20650 ENOG4105QYV Membrane HVZ20_20665 ENOG4105EAH synthase HVZ20_20670 ENOG4105HVQ Regulatory factor of maltose metabolism HVZ20_20680 ENOG4105VFK BolA family HVZ20_20685 ENOG4105UE2 Part of the ABC transporter complex MlaFEDB that actively prevents phospholipid accumulation at the cell surface. Probably maintains lipid asymmetry in the outer membrane by retrograde trafficking of phospholipids from the outer membrane to the inner membrane HVZ20_20690 ENOG4105E3I toluene tolerance HVZ20_20695 ENOG4107PE3 Mammalian cell entry related domain protein HVZ20_20700 ENOG4105CY3 ABC transporter, permease HVZ20_20705 ENOG4105DHJ ABC, transporter HVZ20_20710 ENOG4105FEU K -dependent Na -Ca exchanger HVZ20_20715 ENOG4105C2X Arabinose 5-phosphate isomerase HVZ20_20720 ENOG4108Z4R 3-deoxy-d-manno-octulosonate 8-phosphate phosphatase HVZ20_20725 ENOG4108P1K Required for the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane (By similarity) HVZ20_20730 ENOG4105WI0 lipopolysaccharide transport periplasmic protein lptA HVZ20_20735 ENOG4108IUZ ABC transporter HVZ20_20740 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HVZ20_20745 ENOG41080QH sigma 54 modulation protein ribosomal protein S30EA HVZ20_20750 ENOG4107RM2 PTS IIA-like nitrogen-regulatory protein PtsN HVZ20_20760 ENOG41080Z8 PHOSPHOCARRIER protein HVZ20_20765 ENOG4108NIH transferase activity, transferring phosphorus-containing groups HVZ20_20775 ENOG4108556 Isoprenoid biosynthesis protein with amidotransferase-like domain HVZ20_20780 ENOG4105BZU Histidine kinase HVZ20_20785 ENOG4105N5T Radical SAM Protein HVZ20_20790 ENOG4105CBC glutamate synthase HVZ20_20795 ENOG4105BZ8 glutamate synthase HVZ20_20800 ENOG4108R66 Conserved Protein HVZ20_20830 ENOG4105CEE C4-dicarboxylate transporter HVZ20_20835 ENOG4105KB2 stringent starvation protein b HVZ20_20840 ENOG4107MKT Stringent starvation protein a HVZ20_20855 ENOG4105D6Z AFG1 family ATPase HVZ20_20860 ENOG4108W2Q Cytochrome d ubiquinol oxidase subunit III HVZ20_20865 ENOG4105C0H protease HVZ20_20870 ENOG4105C0H protease HVZ20_20875 ENOG4105VNT transposase (IS4 family) protein HVZ20_20890 ENOG4105RID UPF0379 protein yhcN HVZ20_20895 ENOG4105UNR (Barnase) inhibitor HVZ20_20910 ENOG4105ZQC membrane protein AaeX HVZ20_20915 ENOG4105CR8 Transcriptional regulator HVZ20_20925 ENOG4105D1U peptidase U62 modulator of DNA gyrase HVZ20_20930 ENOG4105QD6 exported protein HVZ20_20935 ENOG4105C03 ribonuclease HVZ20_20940 ENOG4108Z03 MAF-like protein HVZ20_20945 ENOG4105VQ7 Rod shape-determining protein MreD HVZ20_20950 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) HVZ20_20960 ENOG41062P1 Diguanylate cyclase phosphodiesterase HVZ20_20965 ENOG4105D3Z quinone oxidoreductase, yhdh yhfp family HVZ20_20980 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein HVZ20_20985 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase HVZ20_20990 ENOG4105RG0 Membrane HVZ20_20995 ENOG4108IA2 Sodium pantothenate symporter HVZ20_21005 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) HVZ20_21015 ENOG4105CEC DNA methylase N-4 N-6 HVZ20_21020 ENOG41061ME transport protein HVZ20_21025 ENOG4108XG4 DNA-binding transcriptional regulator HVZ20_21030 ENOG4105C1P efflux transporter, rnd family, mfp subunit HVZ20_21035 ENOG4105BZS acriflavin resistance protein HVZ20_21040 ENOG4105XCM membrane LIPOPROTEIN HVZ20_21050 ENOG4105EZ7 amino acid ABC transporter HVZ20_21055 ENOG4105DRP amino acid AbC transporter HVZ20_21060 ENOG4105CDA abc transporter atp-binding protein HVZ20_21095 ENOG4108Z0R Transferase HVZ20_21100 ENOG4105SG3 Protein of unknown function (DUF1488) HVZ20_21115 ENOG4108WI1 Dna topoisomerase HVZ20_21125 ENOG4105C79 DNA protecting protein DprA HVZ20_21145 ENOG4105C1A potassium transporter peripheral membrane HVZ20_21155 ENOG4105VCN Rescues the ribosomes stalled at the 3' end of non-stop mRNAs. May induce hydrolysis of the ribosome-bound peptidyl-tRNA. This activity is crucial when the stalled ribosome can not be rescued by the SsrA(tmRNA)-SmpB quality control system HVZ20_21160 ENOG4105W1Y Transcriptional regulator HVZ20_21165 ENOG4105VTS DnaJ-like, subfamily C HVZ20_21195 ENOG41067V7 50S ribosomal protein L36 HVZ20_21200 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) HVZ20_21245 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) HVZ20_21290 ENOG41080KG One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) HVZ20_21315 ENOG4108UQY Iron-storage protein HVZ20_21320 ENOG4105W53 bacterioferritin-associated ferredoxin HVZ20_21360 ENOG4105WWK YheO domain protein HVZ20_21365 ENOG4108V1T peptidylprolyl cis-trans isomerase HVZ20_21375 ENOG4108YZY peptidylprolyl cis-trans isomerase HVZ20_21380 ENOG4105VKU nucleicacid-binding protein HVZ20_21395 ENOG4105C5H ABC transporter HVZ20_21400 ENOG4105DNZ Alpha Beta Hydrolase HVZ20_21410 ENOG4105CJE phosphoribulokinase (EC 2.7.1.19) HVZ20_21415 ENOG4108UKZ OsmC family HVZ20_21425 ENOG410613R integral membrane protein, YccS YhfK family HVZ20_21430 ENOG4105C8Y Acetylornithine aminotransferase HVZ20_21435 ENOG4105DDQ anthranilate synthase HVZ20_21440 ENOG4105MZU cell filamentation protein HVZ20_21450 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) HVZ20_21460 ENOG4107QZF nitrite reductase NADPH large subunit HVZ20_21465 ENOG4105WZK nitrite reductase NADPH small subunit HVZ20_21470 ENOG4107V9H nitrite transporter HVZ20_21480 ENOG4105VYH HVZ20_21490 ENOG4106M0N transport system permease protein HVZ20_21495 ENOG4105MUZ Protein of unknown function DUF2620 HVZ20_21500 ENOG41080QX K07048 phosphotriesterase-related protein HVZ20_21505 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) HVZ20_21510 ENOG4108626 Racemase HVZ20_21515 ENOG4105RMW regulation of transcription, DNA-dependent HVZ20_21520 ENOG4108M21 HVZ20_21525 ENOG4105C31 Tryptophanyl-tRNA synthetase HVZ20_21530 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) HVZ20_21535 ENOG4105DJV ribulose-phosphate 3-epimerase HVZ20_21540 ENOG4105DFE Dna adenine methylase HVZ20_21545 ENOG4105EGB membrane protein DamX HVZ20_21560 ENOG4105E4G Type IV pilus HVZ20_21565 ENOG4105ITY Required for the use of extracellular DNA as a nutrient HVZ20_21570 ENOG4105XPX DNA utilization protein HofO HVZ20_21575 ENOG41065NF Fimbrial assembly family protein HVZ20_21580 ENOG4108U1Q Pilus assembly protein HVZ20_21585 ENOG4108JQC penicillin-binding protein 1A HVZ20_21590 ENOG4107RK2 ADP-ribose diphosphatase NudE HVZ20_21595 ENOG4105DQY intracellular growth attenuator HVZ20_21600 ENOG4107Y3D HAD-superfamily hydrolase subfamily IA variant 3 HVZ20_21605 ENOG4105VEJ Heat shock protein HVZ20_21615 ENOG4108MAJ Membrane HVZ20_21635 ENOG4105E0F Histidine kinase HVZ20_21645 ENOG4108RRZ Transcription elongation factor GreB HVZ20_21650 ENOG4105BZM domain protein HVZ20_21655 ENOG4105XFK Ferrous iron transport protein A HVZ20_21660 ENOG4105CE1 Ferrous iron transport protein b HVZ20_21670 ENOG4105DNE Transposase HVZ20_21675 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) HVZ20_21680 ENOG4105MJ2 Competence protein HVZ20_21690 ENOG4105C6Z Gluconate HVZ20_21695 ENOG4107RTM 4-alpha-glucanotransferase (EC 2.4.1.25) HVZ20_21700 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) HVZ20_21715 ENOG4105E0Y RtcB Protein HVZ20_21720 ENOG4105CYB regulatoR HVZ20_21725 ENOG4105E98 transcriptional regulator DeoR family HVZ20_21740 ENOG4105C6V Glycerol-3-phosphate dehydrogenase HVZ20_21755 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) HVZ20_21780 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) HVZ20_21785 ENOG41076UM multiple antibiotic resistance (MarC)-related protein HVZ20_21790 ENOG4105C6Z Gluconate HVZ20_21795 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family HVZ20_21800 ENOG4105DIQ Transcriptional regulator HVZ20_21805 ENOG4105C2I pirin domain protein HVZ20_21810 ENOG4105D9R oxidoreductase HVZ20_21815 ENOG4105WCN acetyltransferase HVZ20_21825 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) HVZ20_21830 ENOG4105WC8 Conserved Protein HVZ20_21835 ENOG4107T6V glycerophosphoryl diester phosphodiesterase HVZ20_21855 ENOG4105BZ7 extracellular solute-binding protein family 1 HVZ20_21860 ENOG4108IV0 ABC, transporter HVZ20_21865 ENOG4105C0Z ABC transporter HVZ20_21870 ENOG4105CF8 branched-chain amino acid ABC transporter, permease HVZ20_21875 ENOG4105C32 Amino acid ABC transporter (Permease) HVZ20_21880 ENOG4105CP9 extracellular ligand-binding receptor HVZ20_21885 ENOG4105U59 -acetyltransferase HVZ20_21890 ENOG4105CP9 extracellular ligand-binding receptor HVZ20_21895 ENOG4105DEK Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HVZ20_21900 ENOG4105CRP Part of the ABC transporter FtsEX involved in HVZ20_21905 ENOG4105CAK Cell division ATP-binding protein ftsE HVZ20_21910 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) HVZ20_21915 ENOG4106H78 methyltransferase HVZ20_21920 ENOG4105MG3 Membrane HVZ20_21930 ENOG4107FS9 Membrane HVZ20_21945 ENOG4105EX9 Membrane HVZ20_21950 ENOG4108W1V Lipoprotein HVZ20_21955 ENOG4105F9N Major Facilitator Superfamily HVZ20_21960 ENOG4105DSF transport protein HVZ20_21965 ENOG4107YAK holo-(acyl carrier protein) synthase 2 HVZ20_21970 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein HVZ20_21975 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HVZ20_21980 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HVZ20_21985 ENOG4106665 Part of the ABC transporter complex NikABCDE involved in nickel import. Responsible for energy coupling to the transport system (By similarity) HVZ20_21990 ENOG4105EFJ Part of the ABC transporter complex NikABCDE involved in nickel import. Responsible for energy coupling to the transport system (By similarity) HVZ20_22010 ENOG4105CMI transporter HVZ20_22015 ENOG4105CJ1 ABC, transporter HVZ20_22020 ENOG4105D0S secretion protein (HlyD HVZ20_22025 ENOG4107UNS conserved inner membrane protein HVZ20_22030 ENOG4105CBX hi0933 family HVZ20_22035 ENOG4105CJ3 phosphate transporter HVZ20_22050 ENOG4105DUX Transporter HVZ20_22060 ENOG4105DGW oligopeptidase A HVZ20_22065 ENOG4105D6S protein involved in catabolism of external DNA HVZ20_22070 ENOG4105DC8 reductase HVZ20_22080 ENOG4105K89 arsenate reductase HVZ20_22090 ENOG4105Y4Z Outer Membrane Lipoprotein HVZ20_22100 ENOG4106QJH hemin transport protein HVZ20_22105 ENOG4107ENK receptor HVZ20_22115 ENOG4105D4P Coproporphyrinogen iii oxidase HVZ20_22120 ENOG41090JE Utilization Protein HVZ20_22130 ENOG4105EHG Permease protein HVZ20_22135 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) HVZ20_22140 ENOG4105KT7 mgtC SapB transporter HVZ20_22145 ENOG4105XXV Acid-resistance protein HVZ20_22150 ENOG41060V2 Acid-resistance protein HVZ20_22155 ENOG4108YK4 Acid-resistance membrane protein HVZ20_22160 ENOG4106WJ0 Regulates the expression of several genes involved in acid resistance. Required for the expression of gadA and gadBC, among others, regardless of media or growth conditions. Binds directly to the 20 bp GAD box found in the control regions of both loci HVZ20_22170 ENOG4105C1P efflux transporter, rnd family, mfp subunit HVZ20_22175 ENOG4105BZS acriflavin resistance protein HVZ20_22180 ENOG4105D3F AraC Family Transcriptional Regulator HVZ20_22190 ENOG4105CVK Glutamate decarboxylase HVZ20_22195 ENOG4105CA0 peroxidase HVZ20_22205 ENOG4106S2D Transcriptional regulator HVZ20_22210 ENOG4105CBN LysR family transcriptional regulator HVZ20_22215 ENOG4107H3J ribonuclease HVZ20_22220 ENOG4105CSH Transporter HVZ20_22225 ENOG41066T0 asmA family HVZ20_22230 ENOG4105CMB EAL domain-containing protein HVZ20_22235 ENOG4107SS6 2-dehydro-3-deoxygluconokinase HVZ20_22240 ENOG4105CS0 peptidase HVZ20_22250 ENOG4105BZU Histidine kinase HVZ20_22255 ENOG4105EJG cellulose synthase HVZ20_22260 ENOG4105K2Z endo-1,4-d-glucanase (EC 3.2.1.4) HVZ20_22265 ENOG4107EEX Cellulose synthase regulator protein HVZ20_22270 ENOG4107QZ7 Cellulose synthase catalytic subunit HVZ20_22280 ENOG410661M cytoplasmic protein HVZ20_22285 ENOG4105U74 cellulose biosynthesis protein BcsE HVZ20_22290 ENOG4105WQA Cellulose biosynthesis protein BcsF HVZ20_22295 ENOG4105D1V cellulose synthase operon protein YhjU HVZ20_22310 ENOG4105C44 Serine transporter HVZ20_22315 ENOG4108KSB HipA-like N-terminal domain HVZ20_22320 ENOG4105MHH HipA N-terminal domain protein HVZ20_22325 ENOG4107A4G HTH_XRE HVZ20_22330 ENOG4108JQ7 (ABC) transporter HVZ20_22335 ENOG4105C3U ABC transporter HVZ20_22340 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HVZ20_22345 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HVZ20_22350 ENOG4105DEF Extracellular solute-binding protein, family 5 HVZ20_22360 ENOG4105DIJ Phosphoethanolamine transferase HVZ20_22365 ENOG4106UCC Fimbrial protein HVZ20_22370 ENOG4105MHR Fimbrial protein HVZ20_22375 ENOG4105CW0 outer membrane usher protein HVZ20_22380 ENOG4108VCD Chaperone HVZ20_22385 ENOG4106EAR Fimbrial protein HVZ20_22390 ENOG4108SER Transposase HVZ20_22395 ENOG4105FCD Major Facilitator HVZ20_22400 ENOG4105EAX Putative lipase HVZ20_22405 ENOG4108R3E Dna-3-methyladenine glycosylase i HVZ20_22410 ENOG4105HNP -acetyltransferase HVZ20_22415 ENOG4107QY8 reductase HVZ20_22420 ENOG4108ZG0 Ompa motb domain protein HVZ20_22430 ENOG4106JH6 (LipO)protein HVZ20_22435 ENOG4105MVF Transcriptional regulator HVZ20_22445 ENOG41060TC Hok gef cell toxic protein HVZ20_22460 ENOG4105C5Q Transcriptional regulator HVZ20_22465 ENOG4108I5G Major Facilitator superfamily HVZ20_22470 ENOG4105CXK mandelate racemase muconate lactonizing HVZ20_22485 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase HVZ20_22495 ENOG4105CCA Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity) HVZ20_22500 ENOG4105DIJ Phosphoethanolamine transferase HVZ20_22505 ENOG4106R3P AraC family transcriptional regulator HVZ20_22510 ENOG4108XCZ PTS System HVZ20_22515 ENOG4108AHH pyruvate formate lyase II activase HVZ20_22525 ENOG4108YRF PTS System HVZ20_22530 ENOG4105DM4 PTS System HVZ20_22535 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) HVZ20_22540 ENOG4107T9Z Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) HVZ20_22545 ENOG4105DCT glycerol dehydrogenase HVZ20_22550 ENOG4108XC3 NADH ubiquinone oxidoreductase HVZ20_22555 ENOG4108Q5Y Membrane HVZ20_22565 ENOG4105SYT Methylenetetrahydrofolate reductase HVZ20_22605 ENOG4105DRB nucleoside-specific channel-forming protein HVZ20_22610 ENOG4105CFH Aspartokinase HVZ20_22615 ENOG4105C28 cystathionine HVZ20_22625 ENOG4107S01 Repressor protein MetJ HVZ20_22635 ENOG4105C25 Primosomal protein n' HVZ20_22640 ENOG4105ETE Transcriptional regulator (LacI family HVZ20_22645 ENOG41063M6 Cell Division Protein HVZ20_22660 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase HVZ20_22670 ENOG4105VNT transposase (IS4 family) protein HVZ20_22680 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) HVZ20_22690 ENOG4105CBT Fructose-1,6-bisphosphatase HVZ20_22695 ENOG4105DP0 ferredoxin-NADP reductase HVZ20_22705 ENOG41065TG regulatoR HVZ20_22710 ENOG4108VTS Membrane HVZ20_22715 ENOG4105EBK exported protein HVZ20_22755 ENOG4105FMW periplasmic HVZ20_22760 ENOG4105E3W Two component transcriptional regulator (Winged helix family HVZ20_22765 ENOG4105E0F Histidine kinase HVZ20_22770 ENOG4108RPX mosc domain containing protein HVZ20_22780 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) HVZ20_22830 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) HVZ20_22840 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein HVZ20_22845 ENOG4108MG3 formate dehydrogenase HVZ20_22865 ENOG4105W2W Cytotoxic translational repressor of toxin-antitoxin stability system HVZ20_22875 ENOG4105SUU thioesterase domain HVZ20_22890 ENOG4105EJU HAD-superfamily hydrolase subfamily IA variant 3 HVZ20_22900 ENOG4105CSH Transporter HVZ20_22910 ENOG4105CPQ Dehydrogenase HVZ20_22915 ENOG4105D2M Aldolase HVZ20_22920 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase HVZ20_22925 ENOG4108MGF sugar kinase HVZ20_22930 ENOG4105E98 transcriptional regulator DeoR family HVZ20_22935 ENOG4105CI3 gtp-binding protein typa HVZ20_22940 ENOG4105C5F glutamine synthetase HVZ20_22945 ENOG4105CUX Signal transduction histidine kinase HVZ20_22950 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family HVZ20_22955 ENOG4106FIY HVZ20_22960 ENOG4105D4P Coproporphyrinogen iii oxidase HVZ20_22975 ENOG4108RS6 transposase HVZ20_22980 ENOG4105C2M dna polymerase I HVZ20_22985 ENOG4106HNH Acyl-transferase HVZ20_22995 ENOG4108Z33 Thiol disulfide Interchange Protein HVZ20_23000 ENOG4105E27 serine threonine protein kinase HVZ20_23005 ENOG4105PC1 Conserved Protein HVZ20_23010 ENOG4105C6R Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) HVZ20_23015 ENOG4105FNP Molybdopterin-guanine dinucleotide biosynthesis protein b HVZ20_23045 ENOG4108RR8 protoporphyrinogen oxidase HVZ20_23050 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) HVZ20_23055 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein HVZ20_23075 ENOG4108EX3 reductase HVZ20_23080 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) HVZ20_23085 ENOG4105MDZ Transcriptional activator rfaH HVZ20_23095 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) HVZ20_23100 ENOG4105X8U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity) HVZ20_23105 ENOG4105WKS Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) HVZ20_23115 ENOG4105JC1 sterol-binding domain protein HVZ20_23125 ENOG4105CGY Dna recombination protein HVZ20_23130 ENOG4108I5U Uridine phosphorylase HVZ20_23135 ENOG4105CDZ Carboxymethylenebutenolidase (EC 3.1.1.45) HVZ20_23140 ENOG4106XMA In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2 (By similarity) HVZ20_23150 ENOG4107R1Q Membrane protein FdrA HVZ20_23165 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) HVZ20_23170 ENOG4105DZ2 Transcriptional regulator HVZ20_23175 ENOG4105EMK carboxylate amino acid amine transporter HVZ20_23180 ENOG4105DQF Hydrolase HVZ20_23185 ENOG4108EUD Lysophospholipase HVZ20_23190 ENOG410829K Lysine exporter protein (Lyse ygga) HVZ20_23195 ENOG4105CCF Lysine exporter protein (Lyse ygga) HVZ20_23200 ENOG4105C9U ATP-dependent DNA helicase RecQ HVZ20_23205 ENOG4105HDD phospholipase HVZ20_23210 ENOG4108VUY thioesterase Superfamily protein HVZ20_23215 ENOG4105FR1 rard protein HVZ20_23220 ENOG4107QUT magnesium and cobalt transport protein CorA HVZ20_23225 ENOG4107V4F S-adenosyl-l-methionine hydroxide adenosyltransferase HVZ20_23230 ENOG4105C4R Atp-dependent dna helicase HVZ20_23235 ENOG4105DFC had-superfamily hydrolase, subfamily ia, variant HVZ20_23245 ENOG4105CT0 Protein of unknown function, DUF484 HVZ20_23255 ENOG4105S7Z (LipO)protein HVZ20_23275 ENOG4107T0K Adenylate cyclase HVZ20_23285 ENOG41076E6 Uroporphyrinogen-III Synthase HVZ20_23290 ENOG4105ECF c-methyltransferase HVZ20_23295 ENOG410601J HemY protein HVZ20_23300 ENOG4105ENH Sulfatase HVZ20_23305 ENOG4105C4X radical SAM domain protein HVZ20_23330 ENOG4105C85 amino acid HVZ20_23350 ENOG4105EGZ biosynthesis protein HVZ20_23355 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase HVZ20_23360 ENOG4108WJ1 acetyltransferase HVZ20_23365 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) HVZ20_23370 ENOG4105C1B dTDP-glucose 4-6-dehydratase HVZ20_23375 ENOG4107QQG Dehydrogenase HVZ20_23380 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase HVZ20_23385 ENOG4105SFE lipopolysaccharide biosynthesis protein HVZ20_23390 ENOG4105ESV Glycosyl transferase, family 4 HVZ20_23395 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) HVZ20_23420 ENOG4105C4R Atp-dependent dna helicase HVZ20_23425 ENOG4105KQ5 peptidylprolyl cis-trans isomerase HVZ20_23435 ENOG4105EMY transcriptional regulator HVZ20_23440 ENOG4105C7B Threonine dehydratase HVZ20_23450 ENOG4105CM2 brancheD-chain amino acid aminotransferase HVZ20_23455 ENOG4105P3Y Acetolactate synthase 2 regulatory subunit HVZ20_23475 ENOG4105C0P Mg chelatase subunit ChlI HVZ20_23480 ENOG4108WFC UPF0438 protein yifE HVZ20_23520 ENOG4107EJG GntR family transcriptional regulator HVZ20_23525 ENOG4105C0R drug resistance transporter emrb qaca subfamily HVZ20_23530 ENOG4105ETE Transcriptional regulator (LacI family HVZ20_23535 ENOG4108RVA ribokinase HVZ20_23540 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator HVZ20_23545 ENOG4105CNN ABC, transporter HVZ20_23550 ENOG4105C2J ABC transporter HVZ20_23555 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) HVZ20_23580 ENOG4108VVK transcriptional Regulator, AsnC HVZ20_23585 ENOG4105QTB Flavodoxin HVZ20_23600 ENOG4105GXX Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit I associates with the membrane and may be involved with cation translocation HVZ20_23645 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) HVZ20_23650 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) HVZ20_23655 ENOG4107QMV Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity) HVZ20_23660 ENOG4105C8U phosphate abc transporter HVZ20_23665 ENOG4105E2Z phosphate ABC transporter (Permease HVZ20_23670 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) HVZ20_23675 ENOG4108UTW Plays a role in the regulation of phosphate uptake HVZ20_23685 ENOG4105C5Y PTS System HVZ20_23690 ENOG4105CS2 ec 3.2.1.21 HVZ20_23695 ENOG4108P68 Outer membrane porin HVZ20_23700 ENOG4105DYC esterase HVZ20_23705 ENOG4107VKM 6-phosphogluconolactonase HVZ20_23725 ENOG4107UB3 HAD-superfamily hydrolase subfamily IA variant 3 HVZ20_23730 ENOG4105C7N Xanthine uracil vitamin C permease HVZ20_23735 ENOG4108YYH Nadph-dependent fmn reductase HVZ20_23740 ENOG4105E8Q phosphopantetheinyl transferase HVZ20_23745 ENOG4105G2Y Transcriptional regulator HVZ20_23755 ENOG4108P6C Tryptophan transporter of low affinity HVZ20_23795 ENOG4105VG0 50S ribosomal protein l34 HVZ20_24000 ENOG41074AV Hok/gef family HVZ20_24020 ENOG4105FEQ ParB domain protein nuclease HVZ20_24070 ENOG4108SER Transposase HVZ20_24080 ENOG4106JQ7 HVZ20_24085 ENOG41073YN Protein of unknown function (DUF1380) HVZ20_24175 ENOG4105BZU Histidine kinase HVZ20_24195 ENOG4108SER Transposase HVZ20_24265 ENOG4105D13 transposase HVZ20_24270 ENOG4108C33 Resolvase HVZ20_24275 ENOG4108MIB HVZ20_24325 ENOG4105ESI atpase involved in dna repair HVZ20_24365 ENOG41073YN Protein of unknown function (DUF1380) HVZ20_24375 ENOG4108SER Transposase HVZ20_24430 ENOG4105FEQ ParB domain protein nuclease HVZ20_24455 ENOG4108YXQ IS66 Orf2 family protein HVZ20_24460 ENOG4105E5H Transposase