locus-tag class description HVZ24_00010 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) HVZ24_00020 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HVZ24_00025 ENOG4105VP5 Bacterial protein of unknown function (DUF937) HVZ24_00030 ENOG410667J hydrolase HVZ24_00035 ENOG410657R replicase EC 2.7 HVZ24_00040 ENOG4105EMF GntR family transcriptional regulator HVZ24_00045 ENOG4105EI3 2-dehydro-3-deoxygalactonokinase EC 2.7.1.58 HVZ24_00050 ENOG4108RTU Aldolase HVZ24_00060 ENOG4105DJB Major Facilitator Superfamily HVZ24_00065 ENOG4107WAP fad NAD(P)-binding domain HVZ24_00070 ENOG4105D99 atp gtp-binding protein HVZ24_00075 ENOG4105R2A (LipO)protein HVZ24_00095 ENOG4105FDP GntR family transcriptional regulator HVZ24_00100 ENOG4105CI1 PTS System HVZ24_00110 ENOG4108AHD Transcriptional regulator HVZ24_00115 ENOG4107RUZ Sss sodium solute transporter superfamily HVZ24_00120 ENOG4105CBG Sulfatase HVZ24_00125 ENOG4106DRA Inner membrane protein YidI HVZ24_00130 ENOG4105VG5 Membrane HVZ24_00135 ENOG4105JP4 Inner membrane protein yidG HVZ24_00140 ENOG4105J13 transcriptional regulator HVZ24_00145 ENOG4105E5M Multidrug resistance protein D HVZ24_00160 ENOG4105C7K acetolactate synthase HVZ24_00165 ENOG4105M71 acetolactate synthase 1 regulatory subunit HVZ24_00170 ENOG4108KX4 response regulator HVZ24_00175 ENOG4105BZU Histidine kinase HVZ24_00180 ENOG4105CXY transporter HVZ24_00185 ENOG4105CXY transporter HVZ24_00190 ENOG4105CPN adenine deaminase HVZ24_00195 ENOG4105C7N Xanthine uracil vitamin C permease HVZ24_00200 ENOG4108SAJ Protein of unknown function (DUF1198) HVZ24_00210 ENOG4105T8A Uncharacterized protein YicS HVZ24_00215 ENOG4105D01 (LipO)protein HVZ24_00220 ENOG4108UZ3 Transporter HVZ24_00225 ENOG4105S8Q sugar efflux transporter HVZ24_00240 ENOG4105CT4 transporter HVZ24_00245 ENOG4105CJQ hydrolase, family 31 HVZ24_00250 ENOG4105JV1 AsmA family HVZ24_00255 ENOG4105C2W permease HVZ24_00260 ENOG4105D6U Sodium Glutamate Symporter HVZ24_00265 ENOG4105CB5 ATP-dependent DNA helicase recG HVZ24_00270 ENOG4105FE8 tRNA (Guanosine-2'-O-)-methyltransferase HVZ24_00275 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) HVZ24_00285 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) HVZ24_00290 ENOG410649J Catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction (By similarity) HVZ24_00295 ENOG4105EN6 Membrane HVZ24_00300 ENOG4105F5P DNA-damage-inducible protein d HVZ24_00305 ENOG4105DSJ YicC domain protein HVZ24_00325 ENOG4108Z1K This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) HVZ24_00330 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase HVZ24_00335 ENOG4105W5Q DNA repair protein (RadC HVZ24_00340 ENOG4105KDC 50s ribosomal protein l28 HVZ24_00360 ENOG4105D8A 3-Deoxy-D-manno-octulosonic-acid transferase HVZ24_00365 ENOG4105DKP glycosyl transferase, family 9 HVZ24_00370 ENOG4107RJ7 Glycosyl transferase (Group 1 HVZ24_00375 ENOG4107543 (lipo)polysaccharide HVZ24_00380 ENOG410650X lipopolysaccharide core region biosynthetic process HVZ24_00385 ENOG4107XU6 Glycosyl transferase (Group 1 HVZ24_00390 ENOG4106AH0 Glycosyl Transferase HVZ24_00395 ENOG4105X1N Glycosyl transferase family 8 HVZ24_00400 ENOG4108PDR lipopolysaccharide core biosynthesis protein HVZ24_00405 ENOG4108QD8 lipopolysaccharide core biosynthesis protein HVZ24_00410 ENOG4108XNZ glycosyl transferase HVZ24_00415 ENOG41068PG O-Antigen polymerase HVZ24_00420 ENOG4105D16 lipopolysaccharide heptosyltransferase i HVZ24_00425 ENOG4105XA0 heptosyltransferase ii HVZ24_00435 ENOG4108SEH involved in lipopolysaccharide biosynthesis HVZ24_00440 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) HVZ24_00445 ENOG4105CPQ Dehydrogenase HVZ24_00450 ENOG4105K64 Glycosyl transferase, family 2 HVZ24_00455 ENOG4105PXI polysaccharide deacetylase HVZ24_00460 ENOG41063SB peptidase HVZ24_00465 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) HVZ24_00470 ENOG4107YZP Rhodanese domain protein HVZ24_00475 ENOG4105VW4 glutaredoxin 3 HVZ24_00490 ENOG4105D7W serine acetyltransferase HVZ24_00495 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) HVZ24_00505 ENOG41073TP transcriptional regulator HVZ24_00510 ENOG4105DAA L-lactate HVZ24_00515 ENOG4108YYI Protein of unknown function (DUF2810) HVZ24_00525 ENOG4105E61 Mannitol repressor protein HVZ24_00535 ENOG4105CTS PTS system mannitol-specific HVZ24_00540 ENOG4105FP6 Protein of unknown function (DUF3302) HVZ24_00545 ENOG4105EFX secretion protein, HlyD family HVZ24_00565 ENOG4105NUP lyase containing HEAT-repeat HVZ24_00570 ENOG4105CNA YD repeat protein HVZ24_00575 ENOG4108U78 Glutathione S-transferase HVZ24_00585 ENOG4105EM7 Selenocysteine-specific translation elongation factor HVZ24_00590 ENOG4105C0A alcohol dehydrogenase HVZ24_00595 ENOG4105C26 Dehydrogenase HVZ24_00605 ENOG4105KK7 inner membrane protein YiaW HVZ24_00610 ENOG4105EFX secretion protein, HlyD family HVZ24_00615 ENOG4108Q2M Transcriptional regulator HVZ24_00620 ENOG4105GNX MltA-interacting MipA family protein HVZ24_00630 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase HVZ24_00635 ENOG41064BZ L-xylulose 5-phosphate 3-epimerase HVZ24_00640 ENOG4105H6Q decarboxylase HVZ24_00645 ENOG4105CMG Carbohydrate kinase HVZ24_00650 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit HVZ24_00655 ENOG4105CG6 trap dicarboxylate transporter dctm subunit HVZ24_00660 ENOG4105XDZ Tripartite ATP-independent periplasmic transporter HVZ24_00665 ENOG4108R66 Conserved Protein HVZ24_00675 ENOG4105J4Q Transcriptional regulator HVZ24_00680 ENOG4108XIB electron transport protein ysaA HVZ24_00685 ENOG4105JKW Valine--pyruvate aminotransferase HVZ24_00690 ENOG4107T9C Alpha amylase catalytic region HVZ24_00695 ENOG4108UR8 BAX protein HVZ24_00700 ENOG4105T16 Transcriptional regulator (AraC family) HVZ24_00705 ENOG4108HWW ABC transporter HVZ24_00710 ENOG4105C2J ABC transporter HVZ24_00715 ENOG4105DFW ABC transporter HVZ24_00720 ENOG4105C93 Xylose Isomerase HVZ24_00725 ENOG4105CMG Carbohydrate kinase HVZ24_00735 ENOG4108Z12 YiaAB two helix domain-containing protein HVZ24_00740 ENOG4105MEV Acyl-transferase HVZ24_00745 ENOG4105RGS lipoprotein ysaB HVZ24_00765 ENOG41060TC Hok gef cell toxic protein HVZ24_00775 ENOG4105MVF Transcriptional regulator HVZ24_00780 ENOG4106JH6 (LipO)protein HVZ24_00785 ENOG4105C5I Dehydrogenase HVZ24_00790 ENOG4108ZG0 Ompa motb domain protein HVZ24_00795 ENOG4107QY8 reductase HVZ24_00800 ENOG4105HNP -acetyltransferase HVZ24_00805 ENOG4108R3E Dna-3-methyladenine glycosylase i HVZ24_00810 ENOG4105EAX Putative lipase HVZ24_00815 ENOG4105FCD Major Facilitator HVZ24_00820 ENOG4105DIJ Phosphoethanolamine transferase HVZ24_00830 ENOG4105DEF Extracellular solute-binding protein, family 5 HVZ24_00835 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HVZ24_00840 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HVZ24_00845 ENOG4105C3U ABC transporter HVZ24_00850 ENOG4108JQ7 (ABC) transporter HVZ24_00855 ENOG4105C44 Serine transporter HVZ24_00865 ENOG4105D1V cellulose synthase operon protein YhjU HVZ24_00870 ENOG4105WQA Cellulose biosynthesis protein BcsF HVZ24_00875 ENOG4105U74 cellulose biosynthesis protein BcsE HVZ24_00880 ENOG410661M cytoplasmic protein HVZ24_00895 ENOG4107QZ7 Cellulose synthase catalytic subunit HVZ24_00900 ENOG4107EEX Cellulose synthase regulator protein HVZ24_00905 ENOG4105K2Z endo-1,4-d-glucanase (EC 3.2.1.4) HVZ24_00910 ENOG4105EJG cellulose synthase HVZ24_00915 ENOG4105BZU Histidine kinase HVZ24_00925 ENOG4105CS0 peptidase HVZ24_00930 ENOG4107SS6 2-dehydro-3-deoxygluconokinase HVZ24_00935 ENOG4105CMB EAL domain-containing protein HVZ24_00940 ENOG41066T0 asmA family HVZ24_00945 ENOG4105CSH Transporter HVZ24_00950 ENOG4107H3J ribonuclease HVZ24_00955 ENOG4105CBN LysR family transcriptional regulator HVZ24_00960 ENOG4106S2D Transcriptional regulator HVZ24_00970 ENOG4105CA0 peroxidase HVZ24_00975 ENOG4105CVK Glutamate decarboxylase HVZ24_00980 ENOG4108NKV transcriptional regulator HVZ24_00990 ENOG4105BZS acriflavin resistance protein HVZ24_00995 ENOG4105C1P efflux transporter, rnd family, mfp subunit HVZ24_01005 ENOG4106WJ0 Regulates the expression of several genes involved in acid resistance. Required for the expression of gadA and gadBC, among others, regardless of media or growth conditions. Binds directly to the 20 bp GAD box found in the control regions of both loci HVZ24_01010 ENOG4108YK4 Acid-resistance membrane protein HVZ24_01015 ENOG41060V2 Acid-resistance protein HVZ24_01020 ENOG4105XXV Acid-resistance protein HVZ24_01025 ENOG4105KT7 mgtC SapB transporter HVZ24_01035 ENOG4105Y4Z Outer Membrane Lipoprotein HVZ24_01045 ENOG4105K89 arsenate reductase HVZ24_01050 ENOG4107R5R arsenical pump membrane protein HVZ24_01055 ENOG4105KBH arsR family transcriptional regulator HVZ24_01065 ENOG4105DC8 reductase HVZ24_01070 ENOG4105D6S protein involved in catabolism of external DNA HVZ24_01075 ENOG4105DGW oligopeptidase A HVZ24_01085 ENOG4105DUX Transporter HVZ24_01100 ENOG4105CJ3 phosphate transporter HVZ24_01105 ENOG4105CBX hi0933 family HVZ24_01110 ENOG4107UNS conserved inner membrane protein HVZ24_01125 ENOG4105D0S secretion protein (HlyD HVZ24_01130 ENOG4105CJ1 ABC, transporter HVZ24_01135 ENOG4105CMI transporter HVZ24_01140 ENOG410600T transposase HVZ24_01145 ENOG4105NUP lyase containing HEAT-repeat HVZ24_01155 ENOG4105CNA YD repeat protein HVZ24_01165 ENOG4105EFJ Part of the ABC transporter complex NikABCDE involved in nickel import. Responsible for energy coupling to the transport system (By similarity) HVZ24_01170 ENOG4106665 Part of the ABC transporter complex NikABCDE involved in nickel import. Responsible for energy coupling to the transport system (By similarity) HVZ24_01175 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HVZ24_01180 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HVZ24_01185 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein HVZ24_01190 ENOG4107YAK holo-(acyl carrier protein) synthase 2 HVZ24_01195 ENOG4105DSF transport protein HVZ24_01200 ENOG4105F9N Major Facilitator Superfamily HVZ24_01205 ENOG4108W1V Lipoprotein HVZ24_01210 ENOG4105EX9 Membrane HVZ24_01220 ENOG4105C59 p-type ATPase HVZ24_01225 ENOG4107FS9 Membrane HVZ24_01235 ENOG4105MG3 Membrane HVZ24_01240 ENOG4106H78 methyltransferase HVZ24_01245 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) HVZ24_01250 ENOG4105CAK Cell division ATP-binding protein ftsE HVZ24_01255 ENOG4105CRP Part of the ABC transporter FtsEX involved in HVZ24_01260 ENOG4105DEK Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HVZ24_01265 ENOG4105CP9 extracellular ligand-binding receptor HVZ24_01270 ENOG4105U59 -acetyltransferase HVZ24_01275 ENOG4105CP9 extracellular ligand-binding receptor HVZ24_01280 ENOG4105C32 Amino acid ABC transporter (Permease) HVZ24_01285 ENOG4105CF8 branched-chain amino acid ABC transporter, permease HVZ24_01290 ENOG4105C0Z ABC transporter HVZ24_01295 ENOG4108IV0 ABC, transporter HVZ24_01300 ENOG4105BZ7 extracellular solute-binding protein family 1 HVZ24_01305 ENOG4105E4X binding-protein-dependent transport systems inner membrane Component HVZ24_01310 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component HVZ24_01315 ENOG4108IJ9 (ABC) transporter HVZ24_01320 ENOG4107T6V glycerophosphoryl diester phosphodiesterase HVZ24_01325 ENOG4105WC8 Conserved Protein HVZ24_01330 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) HVZ24_01335 ENOG4106FA4 HVZ24_01350 ENOG4105GMB type VI secretion system effector, hcp1 family HVZ24_01355 ENOG4105WCN acetyltransferase HVZ24_01360 ENOG4105D9R oxidoreductase HVZ24_01365 ENOG4105C2I pirin domain protein HVZ24_01370 ENOG4105DIQ Transcriptional regulator HVZ24_01375 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family HVZ24_01380 ENOG4105C6Z Gluconate HVZ24_01385 ENOG41076UM multiple antibiotic resistance (MarC)-related protein HVZ24_01390 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) HVZ24_01400 ENOG4108IUM Glycogen debranching enzyme HVZ24_01415 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) HVZ24_01425 ENOG4105C6V Glycerol-3-phosphate dehydrogenase HVZ24_01440 ENOG4105E98 transcriptional regulator DeoR family HVZ24_01445 ENOG4105CYB regulatoR HVZ24_01450 ENOG4105E0Y RtcB Protein HVZ24_01455 ENOG4105CKX Catalyzes the conversion of 3'-phosphate to a 2',3'- cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps (A) adenylation of the enzyme by ATP HVZ24_01465 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) HVZ24_01470 ENOG4107RTM 4-alpha-glucanotransferase (EC 2.4.1.25) HVZ24_01475 ENOG4105C6Z Gluconate HVZ24_01485 ENOG4105MJ2 Competence protein HVZ24_01490 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) HVZ24_01495 ENOG4105DNE Transposase HVZ24_01505 ENOG4105CE1 Ferrous iron transport protein b HVZ24_01510 ENOG4105XFK Ferrous iron transport protein A HVZ24_01515 ENOG4105BZM domain protein HVZ24_01520 ENOG4108RRZ Transcription elongation factor GreB HVZ24_01530 ENOG4105E0F Histidine kinase HVZ24_01540 ENOG4108MAJ Membrane HVZ24_01550 ENOG4105VEJ Heat shock protein HVZ24_01555 ENOG4107Y3D HAD-superfamily hydrolase subfamily IA variant 3 HVZ24_01560 ENOG4105DQY intracellular growth attenuator HVZ24_01565 ENOG4107RK2 ADP-ribose diphosphatase NudE HVZ24_01570 ENOG4108JQC penicillin-binding protein 1A HVZ24_01575 ENOG4108U1Q Pilus assembly protein HVZ24_01580 ENOG41065NF Fimbrial assembly family protein HVZ24_01585 ENOG4105XPX DNA utilization protein HofO HVZ24_01590 ENOG4105ITY Required for the use of extracellular DNA as a nutrient HVZ24_01595 ENOG4105E4G Type IV pilus HVZ24_01605 ENOG4105D49 3-dehydroquinate synthase HVZ24_01610 ENOG4105EGB membrane protein DamX HVZ24_01615 ENOG4105DFE Dna adenine methylase HVZ24_01620 ENOG4105DJV ribulose-phosphate 3-epimerase HVZ24_01625 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) HVZ24_01630 ENOG4105C31 Tryptophanyl-tRNA synthetase HVZ24_01635 ENOG4108M21 HVZ24_01640 ENOG4105RMW regulation of transcription, DNA-dependent HVZ24_01645 ENOG4108626 Racemase HVZ24_01650 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) HVZ24_01655 ENOG41080QX K07048 phosphotriesterase-related protein HVZ24_01660 ENOG4105MUZ Protein of unknown function DUF2620 HVZ24_01665 ENOG4106M0N transport system permease protein HVZ24_01670 ENOG4106PKC pyridoxal phosphate binding HVZ24_01675 ENOG4105FDP GntR family transcriptional regulator HVZ24_01680 ENOG4108KPW sugar kinase HVZ24_01685 ENOG4107Y0V Not clear, may be involved in an isomerization step HVZ24_01690 ENOG4107R1S catalyzes the conversion of fructoselysine 6-phosphate to glucose 6-phosphate and lysine HVZ24_01695 ENOG4107QHQ amino acid HVZ24_01700 ENOG4105VYH HVZ24_01710 ENOG4107V9H nitrite transporter HVZ24_01715 ENOG4105WZK nitrite reductase NADPH small subunit HVZ24_01720 ENOG4107QZF nitrite reductase NADPH large subunit HVZ24_01730 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) HVZ24_01740 ENOG4105MZU cell filamentation protein HVZ24_01745 ENOG4105DDQ anthranilate synthase HVZ24_01750 ENOG4105C8Y Acetylornithine aminotransferase HVZ24_01755 ENOG410613R integral membrane protein, YccS YhfK family HVZ24_01765 ENOG4108UKZ OsmC family HVZ24_01770 ENOG4105CJE phosphoribulokinase (EC 2.7.1.19) HVZ24_01780 ENOG4105DNZ Alpha Beta Hydrolase HVZ24_01785 ENOG4105C5H ABC transporter HVZ24_01795 ENOG4105CKD glutathione-regulated potassium-efflux system protein HVZ24_01800 ENOG4105VKU nucleicacid-binding protein HVZ24_01805 ENOG4108YZY peptidylprolyl cis-trans isomerase HVZ24_01815 ENOG4108V1T peptidylprolyl cis-trans isomerase HVZ24_01820 ENOG4105WWK YheO domain protein HVZ24_01825 ENOG4108ZAT Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE (By similarity) HVZ24_01830 ENOG4108ZKU Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions (By similarity) HVZ24_01835 ENOG4105YKK Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions (By similarity) HVZ24_01860 ENOG4108NNZ chitinase HVZ24_01865 ENOG4105W53 bacterioferritin-associated ferredoxin HVZ24_01870 ENOG4108UQY Iron-storage protein HVZ24_01875 ENOG4105EHH Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue (By similarity) HVZ24_01885 ENOG41063JA Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins (By similarity) HVZ24_01890 ENOG4105R04 type II secretion system protein K HVZ24_01905 ENOG41069X0 general secretion pathway protein h HVZ24_01910 ENOG4108VAU general secretion pathway protein G HVZ24_01915 ENOG4105D7Q type ii secretion system HVZ24_01920 ENOG4107QHF type ii secretion system protein e HVZ24_01925 ENOG4105GVR general secretion pathway protein D HVZ24_01930 ENOG4107KSE General secretion pathway protein C HVZ24_01935 ENOG410899B May play a regulatory role under conditions of derepressed gsp gene expression HVZ24_01940 ENOG4107ACA Calcium-binding protein required for initiation of chromosome replication HVZ24_01960 ENOG41080KG One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) HVZ24_02005 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) HVZ24_02050 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) HVZ24_02055 ENOG41067V7 50S ribosomal protein L36 HVZ24_02085 ENOG4105VTS DnaJ-like, subfamily C HVZ24_02090 ENOG4105W1Y Transcriptional regulator HVZ24_02095 ENOG4105VCN Rescues the ribosomes stalled at the 3' end of non-stop mRNAs. May induce hydrolysis of the ribosome-bound peptidyl-tRNA. This activity is crucial when the stalled ribosome can not be rescued by the SsrA(tmRNA)-SmpB quality control system HVZ24_02105 ENOG4105C1A potassium transporter peripheral membrane HVZ24_02125 ENOG4105C79 DNA protecting protein DprA HVZ24_02135 ENOG4108WI1 Dna topoisomerase HVZ24_02150 ENOG4105SG3 Protein of unknown function (DUF1488) HVZ24_02155 ENOG4108Z0R Transferase HVZ24_02195 ENOG4105CDA abc transporter atp-binding protein HVZ24_02200 ENOG4105DRP amino acid AbC transporter HVZ24_02205 ENOG4105EZ7 amino acid ABC transporter HVZ24_02215 ENOG4105XCM membrane LIPOPROTEIN HVZ24_02220 ENOG4105BZS acriflavin resistance protein HVZ24_02225 ENOG4105C1P efflux transporter, rnd family, mfp subunit HVZ24_02230 ENOG4108XG4 DNA-binding transcriptional regulator HVZ24_02235 ENOG41061ME transport protein HVZ24_02240 ENOG4105CEC DNA methylase N-4 N-6 HVZ24_02250 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) HVZ24_02260 ENOG4108IA2 Sodium pantothenate symporter HVZ24_02265 ENOG4105RG0 Membrane HVZ24_02270 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase HVZ24_02275 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein HVZ24_02280 ENOG4105D3Z quinone oxidoreductase, yhdh yhfp family HVZ24_02285 ENOG41062P1 Diguanylate cyclase phosphodiesterase HVZ24_02295 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) HVZ24_02300 ENOG4105VQ7 Rod shape-determining protein MreD HVZ24_02305 ENOG4108Z03 MAF-like protein HVZ24_02310 ENOG4105C03 ribonuclease HVZ24_02315 ENOG4105QD6 exported protein HVZ24_02320 ENOG4105D1U peptidase U62 modulator of DNA gyrase HVZ24_02325 ENOG4105CR8 Transcriptional regulator HVZ24_02330 ENOG4105ZQC membrane protein AaeX HVZ24_02345 ENOG4105UNR (Barnase) inhibitor HVZ24_02350 ENOG4105RID UPF0379 protein yhcN HVZ24_02365 ENOG4105C0H protease HVZ24_02370 ENOG4105C0H protease HVZ24_02375 ENOG4108W2Q Cytochrome d ubiquinol oxidase subunit III HVZ24_02380 ENOG4105D6Z AFG1 family ATPase HVZ24_02395 ENOG4107MKT Stringent starvation protein a HVZ24_02400 ENOG4105KB2 stringent starvation protein b HVZ24_02405 ENOG4105CEE C4-dicarboxylate transporter HVZ24_02410 ENOG4108QBF Transcriptional regulator HVZ24_02420 ENOG4105JHE Major Facilitator Superfamily HVZ24_02430 ENOG41061DF Catalyzes the phosphorylation of N-acetylmannosamine (ManNAc) to ManNAc-6-P (By similarity) HVZ24_02435 ENOG4108R66 Conserved Protein HVZ24_02440 ENOG4105DFS Conserved Protein HVZ24_02465 ENOG4105E6S usher protein( HVZ24_02470 ENOG4108S1B Periplasmic chaperone protein HVZ24_02475 ENOG4106AJS Involved in induction of the so-called NTR enzymes in response to nitrogen deprivation, as well as in glutamate biosynthesis. May mediate the glutamate-dependent repression of the GLT operon HVZ24_02480 ENOG4105BZ8 glutamate synthase HVZ24_02485 ENOG4105CBC glutamate synthase HVZ24_02490 ENOG4105N5T Radical SAM Protein HVZ24_02495 ENOG4105BZU Histidine kinase HVZ24_02500 ENOG4108556 Isoprenoid biosynthesis protein with amidotransferase-like domain HVZ24_02510 ENOG4108NIH transferase activity, transferring phosphorus-containing groups HVZ24_02515 ENOG41080Z8 PHOSPHOCARRIER protein HVZ24_02525 ENOG4107RM2 PTS IIA-like nitrogen-regulatory protein PtsN HVZ24_02530 ENOG41080QH sigma 54 modulation protein ribosomal protein S30EA HVZ24_02535 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HVZ24_02540 ENOG4108IUZ ABC transporter HVZ24_02545 ENOG4105WI0 lipopolysaccharide transport periplasmic protein lptA HVZ24_02550 ENOG4108P1K Required for the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane (By similarity) HVZ24_02555 ENOG4108Z4R 3-deoxy-d-manno-octulosonate 8-phosphate phosphatase HVZ24_02560 ENOG4105C2X Arabinose 5-phosphate isomerase HVZ24_02565 ENOG4105FEU K -dependent Na -Ca exchanger HVZ24_02570 ENOG4105DHJ ABC, transporter HVZ24_02575 ENOG4105CY3 ABC transporter, permease HVZ24_02580 ENOG4107PE3 Mammalian cell entry related domain protein HVZ24_02585 ENOG4105E3I toluene tolerance HVZ24_02590 ENOG4105UE2 Part of the ABC transporter complex MlaFEDB that actively prevents phospholipid accumulation at the cell surface. Probably maintains lipid asymmetry in the outer membrane by retrograde trafficking of phospholipids from the outer membrane to the inner membrane HVZ24_02595 ENOG4105VFK BolA family HVZ24_02605 ENOG4105HVQ Regulatory factor of maltose metabolism HVZ24_02610 ENOG4105EAH synthase HVZ24_02625 ENOG4105QYV Membrane HVZ24_02630 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control HVZ24_02635 ENOG4106HRJ d-alanyl-d-alanine carboxypeptidase HVZ24_02640 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) HVZ24_02645 ENOG4105HBR Rna-binding protein HVZ24_02655 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) HVZ24_02660 ENOG4105EEI dihydropteroate synthase HVZ24_02670 ENOG4105NTZ Preprotein translocase subunit SecG HVZ24_02680 ENOG4105DIJ Phosphoethanolamine transferase HVZ24_02700 ENOG4105CHV Transcription elongation factor NusA HVZ24_02740 ENOG4105C1J atp-dependent rna helicase HVZ24_02745 ENOG4105CIC tryptophan-specific transport protein HVZ24_02750 ENOG4105DEN Luciferase family HVZ24_02770 ENOG4108YYD acetyltransferase HVZ24_02775 ENOG41082IR Excinuclease ABC C subunit domain protein HVZ24_02785 ENOG4107R7Y intracellular protease Pfpi family HVZ24_02790 ENOG4105K4T epimerase HVZ24_02795 ENOG4107S21 permease HVZ24_02800 ENOG4105W4M Transport-associated protein HVZ24_02815 ENOG4105E1C Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1A (PBP1a) (By similarity) HVZ24_02820 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) HVZ24_02825 ENOG4105I74 Fimbrial protein HVZ24_02830 ENOG4105CW0 outer membrane usher protein HVZ24_02835 ENOG4108VCD Chaperone HVZ24_02840 ENOG4105Q10 Fimbrial-like protein HVZ24_02845 ENOG4106HBN Galactosamine-6-phosphate isomerase HVZ24_02850 ENOG4105F3R pts system mannose fructose sorbose family iid HVZ24_02855 ENOG4105ETZ PTS System HVZ24_02870 ENOG4105E70 isomerase HVZ24_02875 ENOG4105CE4 GlcNAc 6-P deacetylase HVZ24_02880 ENOG4108YTN IIa component HVZ24_02885 ENOG4105F3R pts system mannose fructose sorbose family iid HVZ24_02895 ENOG4108RG5 PTS system N-acetylgalactosamine-specific transporter subunit IIB HVZ24_02900 ENOG4105C6Q that is required for full activity and stability of the Y subunit. Could have a chaperone-like function for the proper and stable folding of HVZ24_02905 ENOG4105E98 transcriptional regulator DeoR family HVZ24_02910 ENOG4108R8Z these effects are overcome by concomitant expression of antitoxin SohA (PrlF). Massive overexpression is toxic. Unlike most other characterized TA systems degrades rRNA, and co-folding of the proteins is necessary in vitro for inhibition of the RNase activity. It is not known if it has any sequence-specificity. Acts as a transcription factor. The YhaV PrlF complex binds the prlF-yhaV operon, probably negatively regulating its expression HVZ24_02915 ENOG4105ZEG Suppressor protein HVZ24_02920 ENOG4105CTX dehydratase HVZ24_02925 ENOG4105DJB Major Facilitator Superfamily HVZ24_02935 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase HVZ24_02940 ENOG4105BZW Glycerate kinase HVZ24_02965 ENOG410811B TRANSCRIPTIONal HVZ24_02970 ENOG4105C7B Threonine dehydratase HVZ24_02980 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) HVZ24_02985 ENOG4105C6N Formate acetyltransferase HVZ24_02990 ENOG4105KME endoribonuclease L-psp HVZ24_02995 ENOG4105EJQ L-serine dehydratase HVZ24_03000 ENOG4105C44 Serine transporter HVZ24_03005 ENOG4105CEM UPF0597 protein HVZ24_03010 ENOG4106D80 Uncharacterized protein YhaL HVZ24_03015 ENOG4108CNN domain protein HVZ24_03020 ENOG4105CWB LysR family transcriptional Regulator HVZ24_03025 ENOG4105KAF membrAne HVZ24_03030 ENOG4105KAF membrAne HVZ24_03035 ENOG4105CHF Glutathione S-transferase HVZ24_03040 ENOG4108VBZ doxx family HVZ24_03045 ENOG4105YJD HVZ24_03050 ENOG41090KG Inner membrane protein YqjE HVZ24_03055 ENOG4105NE1 Conserved Protein HVZ24_03060 ENOG4105WAY exported protein HVZ24_03065 ENOG4105IYR Modulates the activity of the EnvZ OmpR two-component regulatory system, probably by directly modulating EnvZ enzymatic activity and increasing stability of phosphorylated OmpR (By similarity) HVZ24_03070 ENOG4106W5V Membrane HVZ24_03075 ENOG4107YCY Transcriptional regulator HVZ24_03080 ENOG4105DPW Major facilitator superfamily MFS_1 HVZ24_03090 ENOG4105CTX dehydratase HVZ24_03095 ENOG4105P66 Membrane HVZ24_03100 ENOG4107QV7 Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system) (By similarity) HVZ24_03105 ENOG4105DU1 integral membrane protein, terc HVZ24_03110 ENOG4105EE0 oxidoreductase HVZ24_03115 ENOG4108UB4 uncharacterized protein ygjQ HVZ24_03120 ENOG4108VKG metal-dependent hydrolase HVZ24_03125 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) HVZ24_03130 ENOG4105R48 this blockage is overcome by subsequent expression of antitoxin HigA. Overexpression causes cleavage of a number of mRNAs in a translation-dependent fashion, suggesting this is an mRNA interferase HVZ24_03135 ENOG4108Z3N Transcriptional regulator HVZ24_03140 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HVZ24_03145 ENOG4107WCA isomerase HVZ24_03150 ENOG4107W6W Conserved Protein HVZ24_03155 ENOG4105E5D amino acid HVZ24_03160 ENOG4105FK9 beta-D-galactosidase beta subunit HVZ24_03165 ENOG4105CNT hydrolase family 2 HVZ24_03170 ENOG4105CQ4 Transcriptional regulator HVZ24_03175 ENOG4108Y51 tRNA-binding protein HVZ24_03180 ENOG4105C8Y Acetylornithine aminotransferase HVZ24_03185 ENOG4107RHT methyl-accepting chemotaxis sensory transducer with Pas Pac sensor HVZ24_03190 ENOG4105NTW Transcriptional regulator HVZ24_03195 ENOG4105Q26 Siderophore-interacting protein HVZ24_03210 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HVZ24_03215 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) HVZ24_03225 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) HVZ24_03230 ENOG4107QPK )-transporter HVZ24_03235 ENOG4107GFK fumarate HVZ24_03240 ENOG4106DSS Tartrate dehydratase subunit alpha HVZ24_03245 ENOG4105EJC lysr family transcriptional regulator HVZ24_03255 ENOG4107ZVW dihydroneopterin aldolase HVZ24_03270 ENOG4106MWK domain protein HVZ24_03275 ENOG4105I7R Adenylate cyclase HVZ24_03280 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) HVZ24_03300 ENOG4107S78 Band 7 protein HVZ24_03305 ENOG4105PV3 Inner membrane protein yqiJ HVZ24_03315 ENOG4108MY7 Fimbrial HVZ24_03320 ENOG4108TTM chaperone HVZ24_03330 ENOG4105H8W Fimbrial protein HVZ24_03335 ENOG4105W0Z cytoplasmic protein HVZ24_03355 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b HVZ24_03360 ENOG4106032 Glutathionylspermidine synthase HVZ24_03370 ENOG4105DFG type I secretion outer membrane protein HVZ24_03375 ENOG41087AY ADP-Ribose pyrophosphatase HVZ24_03380 ENOG4108SX3 cytoplasmic protein HVZ24_03385 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) HVZ24_03390 ENOG4105IPS esterase HVZ24_03395 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HVZ24_03400 ENOG4105VRH Antibiotic biosynthesis monooxygenase HVZ24_03405 ENOG4105NF4 modulator of drug activity HVZ24_03410 ENOG4107DEU Inner membrane protein YgiZ HVZ24_03415 ENOG4105DHQ Histidine kinase HVZ24_03420 ENOG4105XJC Two component transcriptional regulator (Winged helix family HVZ24_03425 ENOG4105H4F exported protein HVZ24_03430 ENOG4105F4I Transcriptional regulator HVZ24_03435 ENOG4105RT5 Toxic component of a toxin-antitoxin (TA) module. An mRNA interferase which has been reported to be translation- independent (PubMed 19690171, PubMed 19943910) and translation- dependent (PubMed 20041169). Cleavage has been reported to occur on either side of G in the sequence GCU (PubMed 19690171) but also after C in GC(A U) sequences (PubMed 19943910). There are only 14 genes in E.coli W3110 (and probably also MG1655) that do not have a GCU sequence and thus are resistant to the mRNA interferase activity. Overexpression causes cessation of cell growth and inhibits cell proliferation via inhibition of translation as well as increasing persister cell formation HVZ24_03440 ENOG4105WJ3 XRE family Transcriptional regulator HVZ24_03445 ENOG4108J59 Extracellular solute-binding protein, family 5 HVZ24_03450 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HVZ24_03455 ENOG4107S7E 1-acyl-sn-glycerol-3-phosphate acyltransferase HVZ24_03460 ENOG4107TZ2 Cell division protein that is required for growth during stress conditions. May be involved in protecting or stabilizing the divisomal assembly under conditions of stress (By similarity) HVZ24_03465 ENOG4105CCT upf0313 protein HVZ24_03475 ENOG4105ZKC Conserved Protein HVZ24_03480 ENOG4105CV8 reductase HVZ24_03485 ENOG4108I6A alcohol dehydrogenase HVZ24_03490 ENOG4105CF7 AraC family transcriptional regulator HVZ24_03495 ENOG4108K81 inner membrane protein YghB HVZ24_03500 ENOG4105C28 cystathionine HVZ24_03505 ENOG4105CWK Biopolymer transport protein, ExbB HVZ24_03510 ENOG4108ZZF transport protein (ExbD) HVZ24_03515 ENOG4105CYX Short-chain dehydrogenase reductase Sdr HVZ24_03525 ENOG4105CPC Aldo Keto reductase HVZ24_03540 ENOG4105E3S small subunit HVZ24_03545 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein HVZ24_03550 ENOG4105CJ5 hydrogenase 2 b cytochrome subunit HVZ24_03555 ENOG4105DPX Hydrogenase, large subunit HVZ24_03560 ENOG4108USZ hydrogenase HVZ24_03565 ENOG4108WGS hydrogenase 2-specific chaperone HVZ24_03575 ENOG41082MF Hydrogenase assembly chaperone hypC hupF HVZ24_03580 ENOG4105CYM Glutathione S-transferase HVZ24_03585 ENOG4106032 Glutathionylspermidine synthase HVZ24_03590 ENOG4105CJ3 phosphate transporter HVZ24_03595 ENOG4108GH0 ATP-binding protein yghT HVZ24_03605 ENOG4106FPV ATP-binding protein YghR HVZ24_03610 ENOG4108S55 polysaccharide biosynthesis protein HVZ24_03620 ENOG4108UUE Transcriptional regulator HVZ24_03625 ENOG4108M8S permease YjgP YjgQ family protein HVZ24_03635 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) HVZ24_03640 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) HVZ24_03650 ENOG4107RCI amp-dependent synthetase and ligase HVZ24_03660 ENOG4108KWP DNA-binding transcriptional regulator GlcC HVZ24_03665 ENOG4105CQB FAD linked oxidase domain protein HVZ24_03670 ENOG4105EU8 FAD linked oxidase domain protein HVZ24_03675 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) HVZ24_03680 ENOG4108ZJF Glcg protein HVZ24_03685 ENOG4107QP3 malate synthase g HVZ24_03690 ENOG4105DAA L-lactate HVZ24_03695 ENOG4105F88 accessory colonization factor AcfD HVZ24_03705 ENOG4105EHH Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue (By similarity) HVZ24_03740 ENOG4105ETE Transcriptional regulator (LacI family HVZ24_03755 ENOG4105VZJ PTS System HVZ24_03760 ENOG4105CK1 PTS System HVZ24_03765 ENOG4105CS2 ec 3.2.1.21 HVZ24_03770 ENOG4105VCP PTS System HVZ24_03790 ENOG4108UQV Membrane HVZ24_03795 ENOG4105CXN decarboxylase HVZ24_03800 ENOG4105EAA nucleoside HVZ24_03815 ENOG4105CEN a g-specific adenine glycosylase HVZ24_03825 ENOG41090ED Protein with unknown function (DUF469) HVZ24_03830 ENOG4105K33 Periplasmic Protein HVZ24_03835 ENOG4105HDK L-asparaginase HVZ24_03840 ENOG4106MH3 alpha helix chain HVZ24_03845 ENOG4105CSA Coproporphyrinogen iii oxidase HVZ24_03850 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) HVZ24_03855 ENOG4105VZ9 UPF0235 protein HVZ24_03860 ENOG4108VIA integral membrane protein HVZ24_03865 ENOG4105DFA alanine racemase domain protein HVZ24_03870 ENOG4105CZX twitching motility protein HVZ24_03885 ENOG4105D7Z glutathione synthase HVZ24_03890 ENOG4105QF0 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) HVZ24_03895 ENOG4105RWS endonuclease I HVZ24_03905 ENOG4107QNK )-transporter HVZ24_03925 ENOG4105DP5 Catalyzes the biosynthesis of agmatine from arginine (By similarity) HVZ24_03935 ENOG4108K0D peptidase, M48 HVZ24_03940 ENOG4105CV1 Transketolase (EC 2.2.1.1) HVZ24_03945 ENOG4108X7Y Mannitol-specific cryptic phosphotransferase enzyme iia HVZ24_03950 ENOG4105CTS PTS system mannitol-specific HVZ24_03955 ENOG4105DXH Alcohol dehydrogenase zinc-binding domain protein HVZ24_03960 ENOG4108Q8A Fructose-1,6-bisphosphatase HVZ24_03965 ENOG4108R4K DNA-binding, transcriptional regulator HVZ24_03970 ENOG4107Z1W Fructose transport system kinase HVZ24_03985 ENOG4105D2N Aldolase HVZ24_03990 ENOG4105D64 Mechanosensitive ion channel HVZ24_03995 ENOG4108ZUB Lysine exporter protein (Lyse ygga) HVZ24_04000 ENOG4105MPN Membrane HVZ24_04005 ENOG4105DEQ transcriptional regulator HVZ24_04010 ENOG4105CYC Transferase HVZ24_04015 ENOG4108M7F enoyl-CoA hydratase isomerase HVZ24_04020 ENOG4105DJT lAO AO transport system ATPase HVZ24_04025 ENOG4105D5P Methylmalonyl-coA mutase HVZ24_04045 ENOG4108JQ1 Dehydrogenase HVZ24_04055 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase HVZ24_04075 ENOG4107RAQ aminopeptidase HVZ24_04080 ENOG4105D0A hydroxylase HVZ24_04085 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family HVZ24_04105 ENOG4105CBI The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor HVZ24_04110 ENOG4105CYX Short-chain dehydrogenase reductase Sdr HVZ24_04115 ENOG4105CS2 ec 3.2.1.21 HVZ24_04120 ENOG4105N5Z UPF0267 protein HVZ24_04125 ENOG4108UT2 hemolysin iii HVZ24_04135 ENOG4105Y75 tpr repeat protein HVZ24_04140 ENOG4108YDB Toxic component of a toxin-antitoxin (TA) module. Overexpression leads to growth arrest after 5 hours, with initial elongation of cells, followed by swelling. The toxic effects are abrogated by coexpression with antitoxin CptB. Interacts with cytoskeletal proteins FtsZ and MreB HVZ24_04145 ENOG41071R3 Low-potential electron donor to a number of redox enzymes (By similarity) HVZ24_04150 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HVZ24_04155 ENOG4105T95 Thiol disulfide interChange protein HVZ24_04160 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) HVZ24_04170 ENOG4105CRK lysyL-tRNA synthetase HVZ24_04175 ENOG4108ZEY Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) HVZ24_04190 ENOG4105C2W permease HVZ24_04195 ENOG4105BZ8 glutamate synthase HVZ24_04200 ENOG4108R8B oxidoreductase Fe-S subunit HVZ24_04205 ENOG4105C7N Xanthine uracil vitamin C permease HVZ24_04210 ENOG4107QUY Guanine deaminase HVZ24_04215 ENOG4105C2W permease HVZ24_04220 ENOG4105C7W Xanthine dehydrogenase HVZ24_04225 ENOG410873Y FAD binding domain in molybdopterin dehydrogenase HVZ24_04230 ENOG4107UUR Chlorohydrolase aminohydrolase HVZ24_04235 ENOG4105BZ8 glutamate synthase HVZ24_04240 ENOG4105MFX 4-diphosphocytidyl-2c-methyl-d-erythritol synthase HVZ24_04245 ENOG4105MJ6 selenium-dependent hydroxylase accessory protein YqeC HVZ24_04250 ENOG4107P0T Selenium-dependent molybdenum hydroxylase system protein, YqeB family HVZ24_04255 ENOG4105C5B carbamate kinase HVZ24_04265 ENOG4107S4Y M20 DapE family protein YgeY HVZ24_04270 ENOG4107RCH Diaminopropionate ammonia-lyase HVZ24_04275 ENOG4105IW6 Carbamoyltransferase HVZ24_04280 ENOG4108JUB Transcriptional regulator HVZ24_04285 ENOG4108UTP (2Fe-2S)-binding domain protein HVZ24_04290 ENOG4108HR6 Dehydrogenase HVZ24_04295 ENOG4105C7W Xanthine dehydrogenase HVZ24_04300 ENOG4108K5P (LipO)protein HVZ24_04320 ENOG41075IY surface presentation of antigens protein SpaP HVZ24_04325 ENOG4105U07 type iii secretion HVZ24_04330 ENOG4108TN6 type iii secretion HVZ24_04335 ENOG4108M6W surface presentation of antigens protein SpaS HVZ24_04340 ENOG4108M6W surface presentation of antigens protein SpaS HVZ24_04355 ENOG4108RC9 Type III secretion system protein HVZ24_04360 ENOG4105Y7Q type iii secretion HVZ24_04365 ENOG4106BTR HVZ24_04370 ENOG4108RBT type iii secretion HVZ24_04400 ENOG4108YAB Invasion protein HVZ24_04425 ENOG4105FV3 HVZ24_04430 ENOG4108TC1 Transcriptional regulator HVZ24_04435 ENOG4105ISV protein with bipartite regulator domain HVZ24_04440 ENOG4108MHD transport protein HVZ24_04445 ENOG4105CHU acetyl-coa acetyltransferase HVZ24_04455 ENOG4105CHR reductase HVZ24_04460 ENOG4107QNK )-transporter HVZ24_04470 ENOG4105RQF LysR family Transcriptional regulator HVZ24_04480 ENOG41060NJ transcriptional regulator HVZ24_04485 ENOG4105CEY Amp-dependent synthetase and ligase HVZ24_04490 ENOG4107S74 Lysophospholipid transporter LplT HVZ24_04495 ENOG4105CPC Aldo Keto reductase HVZ24_04500 ENOG4105SUV lipoprotein YgdR HVZ24_04505 ENOG4105EE5 Membrane protein terC HVZ24_04520 ENOG4108HRM phosphoenolpyruvate--protein phosphotransferase HVZ24_04535 ENOG4105IPU prepilin peptidase dependent protein A HVZ24_04540 ENOG4105JCS prepilin peptidase dependent protein HVZ24_04545 ENOG4105SEN Protein of unknown function (DUF2509) HVZ24_04550 ENOG4105RVB Prepilin peptidase dependent protein c HVZ24_04555 ENOG4105DSY exodeoxyribonuclease V, gamma HVZ24_04560 ENOG4107QXK peptidase HVZ24_04565 ENOG4107QKA exodeoxyribonuclease V beta HVZ24_04570 ENOG4107QYX exodeoxyribonuclease v alpha HVZ24_04575 ENOG4108EKC n-acetylglutamate synthase HVZ24_04580 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase HVZ24_04600 ENOG4105CA3 membrane-bound lytic murein transglycosylase HVZ24_04605 ENOG4105CUZ uba thif-type nad fad binding protein HVZ24_04610 ENOG4105P9C Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity) HVZ24_04615 ENOG4105C9B Cysteine desulfurase HVZ24_04620 ENOG4105M5B (LipO)protein HVZ24_04625 ENOG4105ETT transcriptional Regulator, LysR family HVZ24_04630 ENOG4105M08 Membrane HVZ24_04640 ENOG4107EDW L-fucose operon activator HVZ24_04650 ENOG4105CMG Carbohydrate kinase HVZ24_04655 ENOG4105EHF Converts the aldose L-fucose into the corresponding ketose L-fuculose (By similarity) HVZ24_04660 ENOG4105EDR glucose galactose transporter HVZ24_04665 ENOG4107W7X Aldolase HVZ24_04670 ENOG4105C0A alcohol dehydrogenase HVZ24_04680 ENOG4105EJQ L-serine dehydratase HVZ24_04685 ENOG4105C44 Serine transporter HVZ24_04690 ENOG4105EWT decarboxylase family HVZ24_04695 ENOG4107R1K Catalyzes the NADPH-dependent reduction of 7-cyano-7- deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) (By similarity) HVZ24_04705 ENOG4105WP7 tRNA pseudouridine synthase C HVZ24_04710 ENOG4105DR9 pseudouridine synthase HVZ24_04715 ENOG4105QDK Flavodoxin HVZ24_04720 ENOG4105DJB Major Facilitator Superfamily HVZ24_04725 ENOG4105EQX glucarate dehydratase HVZ24_04730 ENOG4105EQX glucarate dehydratase HVZ24_04735 ENOG4105BZU Histidine kinase HVZ24_04740 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) HVZ24_04745 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) HVZ24_04750 ENOG4106A2Z transcriptional regulator antitoxin, MazE HVZ24_04755 ENOG4105MZG transcriptional modulator of maze toxin, mazf HVZ24_04760 ENOG4105DXN mazG family HVZ24_04775 ENOG4105HA9 of methanol dehydrogenase type HVZ24_04785 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) HVZ24_04790 ENOG4108CWB sugar kinase ygcE HVZ24_04795 ENOG4108ITV Inner membrane protein yqcE HVZ24_04805 ENOG4107R3A FAD linked oxidase domain protein HVZ24_04810 ENOG4105C54 Major Facilitator superfamily HVZ24_04815 ENOG4106IKH Electron transfer flavoprotein HVZ24_04820 ENOG4105YBM electron transfer flavoprotein subunit ygcQ HVZ24_04825 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator HVZ24_04830 ENOG4105WQV ferredoxin-like protein HVZ24_04835 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase HVZ24_04840 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase HVZ24_04855 ENOG4105ET3 Reduction of activated sulfate into sulfite (By similarity) HVZ24_04875 ENOG4105CYR Crispr-associated protein, cse1 family HVZ24_04880 ENOG41061HK CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA) HVZ24_04885 ENOG41060M0 Crispr-associated protein, cse4 family HVZ24_04890 ENOG4108VWQ crispr-associated protein HVZ24_04895 ENOG4108Y7V CRISPR-associated protein, Cse3 family HVZ24_04900 ENOG4105TZK CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. May be involved in the integration of spacer DNA into the CRISPR cassette (By similarity) HVZ24_04905 ENOG4105PWE CRISPR-associated protein cas2 HVZ24_04910 ENOG4108MXK alkaline phosphatase isozyme conversion HVZ24_04915 ENOG4105C11 sulfate adenylyltransferase), subunit 2 HVZ24_04930 ENOG4105N0Z inner membrane protein ygbE HVZ24_04965 ENOG4108K5P (LipO)protein HVZ24_04970 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HVZ24_04975 ENOG4105C6Z Gluconate HVZ24_04980 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) HVZ24_04985 ENOG4105FB2 class II Aldolase HVZ24_04990 ENOG4105G63 Type III effector Hrp-dependent HVZ24_04995 ENOG4105ZXK Dehydrogenase HVZ24_05000 ENOG4105MVE transcriptional regulator HVZ24_05005 ENOG4105MEW serine threonine protein phosphatase HVZ24_05020 ENOG4105VXR cytoplasmic protein HVZ24_05025 ENOG4108JUA Transcriptional regulator HVZ24_05030 ENOG4105C45 hydrogenase expression formation protein (HypE) HVZ24_05035 ENOG4105CQS hydrogenase expression formation protein HypD HVZ24_05040 ENOG41083WG hydrogenase assembly chaperone HVZ24_05045 ENOG4107RSS Hydrogenase accessory protein HypB HVZ24_05050 ENOG410816D Probably plays a role in a hydrogenase nickel cofactor insertion step (By similarity) HVZ24_05055 ENOG4108VRC Formate hydrogenlyase regulatory protein hycA HVZ24_05060 ENOG4108MFN small subunit of hydrogenase-3, iron-sulfur protein (part of formate hydrogenlyase (FHL) complex) HVZ24_05065 ENOG4107R30 NADH dehydrogenase HVZ24_05070 ENOG4107TDF Formate hydrogenlyase subunit 4 HVZ24_05075 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HVZ24_05080 ENOG4108RG7 formate hydrogenlyase complex iron-sulfur subunit HVZ24_05085 ENOG4105C47 NADH ubiquinone oxidoreductase 20 kda subunit HVZ24_05090 ENOG4105I6X formate hydrogenlyase maturation HVZ24_05095 ENOG4108MG9 hydrogenase 3 maturation protease HVZ24_05100 ENOG4105CS2 ec 3.2.1.21 HVZ24_05105 ENOG4105C5Y PTS System HVZ24_05110 ENOG4105DDV Transcriptional regulator (LacI family HVZ24_05115 ENOG4108RC0 Electron transport protein HVZ24_05120 ENOG4105C8H hydrogenase maturation protein Hypf HVZ24_05125 ENOG4108EQM faD-dependent pyridine nucleotide-disulfide oxidoreductase HVZ24_05130 ENOG4108ESE uses NADH to detoxify nitric oxide (NO), protecting several 4Fe-4S NO-sensitive enzymes. Has at least 2 reductase partners, only one of which (NorW, flavorubredoxin reductase) has been identified. NO probably binds to the di-iron center HVZ24_05135 ENOG4108JUA Transcriptional regulator HVZ24_05140 ENOG4105C2X Arabinose 5-phosphate isomerase HVZ24_05145 ENOG410804X Transcriptional regulator HVZ24_05150 ENOG4105J92 DNA-binding transcriptional activator GutM HVZ24_05155 ENOG4107QMF Sorbitol-6-phosphate dehydrogenase HVZ24_05160 ENOG4105VI0 Pts system, glucitol sorbitol-specific HVZ24_05165 ENOG4105DZY Pts system, glucitol sorbitol-specific HVZ24_05170 ENOG410787A Pts system, glucitol sorbitol-specific HVZ24_05175 ENOG4105CVE Lytic murein transglycosylase HVZ24_05180 ENOG4107TH8 cina domain protein HVZ24_05195 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) HVZ24_05200 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) HVZ24_05230 ENOG4107VXZ Hydrolase HVZ24_05235 ENOG4105W39 Membrane HVZ24_05250 ENOG4105C0R drug resistance transporter emrb qaca subfamily HVZ24_05255 ENOG4105CW7 secretion protein, HlyD family HVZ24_05260 ENOG4105NTK Transcriptional repressor Mpra HVZ24_05265 ENOG4105ZED uncharacterized protein ygaH HVZ24_05270 ENOG4108UMN azlc family HVZ24_05280 ENOG4105GIJ Glycine betaine HVZ24_05285 ENOG4108HQS Glycine betaine HVZ24_05290 ENOG4108IJ7 Glycine betaine HVZ24_05295 ENOG4107R25 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HVZ24_05300 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HVZ24_05310 ENOG4105WAZ (Glutaredoxin-like protein) NrdH HVZ24_05315 ENOG4108ZQZ Bacterial protein of unknown function (DUF883) HVZ24_05320 ENOG4108WMJ Protein of unknown function (DUF2002) HVZ24_05325 ENOG4108RNS Exports L-alanine (By similarity) HVZ24_05330 ENOG4108X73 DNA- binding protein HVZ24_05335 ENOG4108V62 Rhodanese domain protein HVZ24_05340 ENOG41080HT Transcriptional regulator, arsr family HVZ24_05345 ENOG4105VPI YqaE family transport protein HVZ24_05350 ENOG4109066 lysm domain bon superfamily protein HVZ24_05355 ENOG4108PVQ transcriptional regulator HVZ24_05360 ENOG4105C85 amino acid HVZ24_05365 ENOG4108JPW Aminotransferase HVZ24_05370 ENOG4105C26 Dehydrogenase HVZ24_05375 ENOG4105D5U fad dependent oxidoreductase HVZ24_05380 ENOG4105EK3 May be involved in the control of utilization of gamma- aminobutyric acid (By similarity) HVZ24_05390 ENOG4105E54 alpha-amylase HVZ24_05415 ENOG4108MGN ATP-binding component of a transport system HVZ24_05430 ENOG4105K5B UPF0225 protein HVZ24_05435 ENOG4105DFP Integrase HVZ24_05450 ENOG4108Z1B Cyclase dehydrase HVZ24_05460 ENOG4105YRI Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) HVZ24_05465 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) HVZ24_05480 ENOG4108JU6 CBS domain protein HVZ24_05485 ENOG4106KVJ cytochrome C assembly protein HVZ24_05490 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY HVZ24_05515 ENOG41090EK ompa motb domain protein HVZ24_05520 ENOG4108KHX Diguanylate cyclase HVZ24_05525 ENOG4108WS1 HVZ24_05530 ENOG4105QP9 Protein of unknown function (DUF2799) HVZ24_05535 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) HVZ24_05540 ENOG4105EHE chorismate mutase- prephenate dehydrogenase HVZ24_05545 ENOG4105CQC Prephenate dehydratase HVZ24_05555 ENOG4108WPH sigma 54 modulation protein ribosomal protein S30EA HVZ24_05560 ENOG4106SNF Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane HVZ24_05565 ENOG4105C34 Pseudouridine synthase HVZ24_05570 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase HVZ24_05575 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit HVZ24_05600 ENOG4105CSH Transporter HVZ24_05605 ENOG4105T42 (LipO)protein HVZ24_05610 ENOG4105JIM Phosphatidylserine synthase HVZ24_05615 ENOG4105CD5 CoA-binding domain protein HVZ24_05620 ENOG4106IUH DTW domain containing protein HVZ24_05625 ENOG4105K63 Thioredoxin HVZ24_05630 ENOG4105EIB trna rrna methyltransferase HVZ24_05650 ENOG41090KR LysR family transcriptional Regulator HVZ24_05655 ENOG4105C1J atp-dependent rna helicase HVZ24_05665 ENOG4108IYU L-aspartate oxidase HVZ24_05675 ENOG4105EMN RNA polymerase sigma factor HVZ24_05680 ENOG41069PW sigma-e factor negative regulatory protein HVZ24_05685 ENOG4105VQK sigma E regulatory protein, MucB RseB HVZ24_05690 ENOG4105WMJ Positive regulator of sigma E, RseC MucC HVZ24_05700 ENOG4105C3F Signal peptidase i HVZ24_05720 ENOG4105CSZ Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity) HVZ24_05735 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding HVZ24_05740 ENOG4106G6Q Transcriptional regulator HVZ24_05745 ENOG4105HYY HAD superfamily (Subfamily IF) hydrolase, YfhB HVZ24_05750 ENOG4108Z6B deaminase HVZ24_05760 ENOG4107QIK phosphoribosylformylglycinamidine synthase HVZ24_05765 ENOG4107WP9 Histidine kinase HVZ24_05770 ENOG4108SKK alpha helix protein HVZ24_05775 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family HVZ24_05785 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) HVZ24_05795 ENOG4108NZE NAGC-like transcriptional regulator HVZ24_05800 ENOG4107HQ7 repeat protein HVZ24_05805 ENOG4105FCA ABC transporter periplasmic-binding protein YphF HVZ24_05810 ENOG4108F37 ATP-binding component of a transport system HVZ24_05815 ENOG4105CNN ABC, transporter HVZ24_05820 ENOG4105CPQ Dehydrogenase HVZ24_05825 ENOG4108ZKT aldose 1-epimerase HVZ24_05830 ENOG4108SB3 DoxX Family HVZ24_05840 ENOG4108QJ2 2,3-dihydroxy-2,3-dihydrophenylpropionate dehydrogenase HVZ24_05855 ENOG4105FUY alpha subunit HVZ24_05860 ENOG4108W5M transcriptional regulator HVZ24_05865 ENOG4105D8G Major Facilitator superfamily HVZ24_05870 ENOG4108MN2 Stationary phase inducible protein CsiE HVZ24_05875 ENOG4107XM9 (LipO)protein HVZ24_05880 ENOG4105ECY inositol monophosphatase HVZ24_05900 ENOG4107XTC May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins HVZ24_05920 ENOG4108ZIT Ferredoxin, 2FE-2S HVZ24_05925 ENOG4105WVQ Fe-S assembly protein IscX HVZ24_05930 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) HVZ24_05935 ENOG4105YYA enhanced serine sensitivity protein SseB HVZ24_05940 ENOG4105KHC sulfurtransferase HVZ24_05945 ENOG4105DN3 alpha-2-macroglobulin domain protein HVZ24_05950 ENOG4108JQB penicillin-binding protein 1C HVZ24_05980 ENOG4105N21 Membrane HVZ24_05995 ENOG4105VPD cellular component movement HVZ24_06000 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) HVZ24_06005 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) HVZ24_06010 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) HVZ24_06015 ENOG41066DY Membrane HVZ24_06020 ENOG4108ZMA Outer membrane lipoprotein HVZ24_06025 ENOG41062G3 Protein of unknown function (DUF2633) HVZ24_06035 ENOG4105BZU Histidine kinase HVZ24_06040 ENOG4105C9X ppx gppa phosphatase HVZ24_06045 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) HVZ24_06050 ENOG4108V3E phosphoribosylglycinamide formyltransferase HVZ24_06055 ENOG4105CXB phosphoribosylaminoimidazole synthetase HVZ24_06065 ENOG4105C2W permease HVZ24_06070 ENOG4108KZ1 Mediates the interaction of DNA replication inititator protein DnaA with DNA polymerase subunit beta sliding clamp (dnaN). Stimulates hydrolysis of ATP-DnaA to ADP-DnaA, rendering DnaA inactive for reinititation, a process called regulatory inhibition of DnaA or RIDA (By similarity) HVZ24_06075 ENOG4105K89 arsenate reductase HVZ24_06080 ENOG4105ERG peptidase m48, ste24p HVZ24_06085 ENOG4105C02 permease HVZ24_06090 ENOG4105TMB Formate nitrite transporter HVZ24_06095 ENOG4108JUA Transcriptional regulator HVZ24_06100 ENOG4105I6X formate hydrogenlyase maturation HVZ24_06105 ENOG4105C47 NADH ubiquinone oxidoreductase 20 kda subunit HVZ24_06115 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HVZ24_06120 ENOG4108JPZ Monovalent cation H antiporter subunit D HVZ24_06125 ENOG4107WQX hydrogenase 4 membrane subunit HVZ24_06130 ENOG4105D65 subunit l HVZ24_06135 ENOG4107TDF Formate hydrogenlyase subunit 4 HVZ24_06140 ENOG4108JPZ Monovalent cation H antiporter subunit D HVZ24_06145 ENOG4108MFN small subunit of hydrogenase-3, iron-sulfur protein (part of formate hydrogenlyase (FHL) complex) HVZ24_06150 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen HVZ24_06155 ENOG4105RH4 Glycine cleavage system transcriptional repressor HVZ24_06160 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) HVZ24_06165 ENOG4107EG0 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) HVZ24_06175 ENOG4105CGZ zinc metallopeptidase HVZ24_06180 ENOG4105E0I Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP) (By similarity) HVZ24_06185 ENOG4106KED esterase YpfH HVZ24_06200 ENOG4105KUZ arsenate reductase HVZ24_06210 ENOG4105BZS acriflavin resistance protein HVZ24_06215 ENOG4105BZU Histidine kinase HVZ24_06220 ENOG4105BZ8 glutamate synthase HVZ24_06230 ENOG4108PVD exported protein HVZ24_06235 ENOG4105CV1 Transketolase (EC 2.2.1.1) HVZ24_06240 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) HVZ24_06245 ENOG4105C6K Malic enzyme HVZ24_06250 ENOG4108VJN May be involved in the formation of a specific microcompartment in the cell in which the metabolism of potentially toxic by-products takes place HVZ24_06255 ENOG4106S4J ethanolamine utilization protein EutP HVZ24_06260 ENOG4105NDK ethanolamine utilization protein HVZ24_06265 ENOG4108PFF ethanolamine utilization cobalamin adenosyltransferase HVZ24_06270 ENOG4107WUY phosphate acetyltransferase HVZ24_06275 ENOG4105KNY Microcompartments protein HVZ24_06280 ENOG4105WVM ethanolamine utilization protein EutN carboxysome structural protein Ccml HVZ24_06285 ENOG4108EKI Dehydrogenase HVZ24_06290 ENOG4107RWI ethanolamine utilization protein eutJ HVZ24_06295 ENOG4105C0A alcohol dehydrogenase HVZ24_06300 ENOG4105ENY Ethanolamine utilization protein eutH HVZ24_06305 ENOG4105DYY Reactivating factor for ethanolamine ammonia lyase HVZ24_06310 ENOG4105CPD ethanolamine ammonia-lyase HVZ24_06320 ENOG4106D67 ethanolamine utilization protein HVZ24_06325 ENOG4108X49 Ethanolamine utilization protein EutK HVZ24_06330 ENOG4108K3Z AraC family transcriptional regulator HVZ24_06340 ENOG4108KNB n-acetylmuramoyl-l-alanine amidase HVZ24_06345 ENOG4108R6G acetyltransferase HVZ24_06350 ENOG4105QZU Inner membrane protein YfeZ HVZ24_06355 ENOG4105E7K (LipO)protein HVZ24_06360 ENOG4105EZR dyp-type peroxidase family protein HVZ24_06365 ENOG4107S1E Beta-lactamase HVZ24_06370 ENOG4105C5Y PTS System HVZ24_06380 ENOG4108PSC Represses the expression of the murPQ operon involved in the uptake and degradation of N-acetylmuramic acid (MurNAc). Binds to two adjacent inverted repeats within the operator region. MurNAc 6-phosphate, the substrate of MurQ, is the specific inducer that weakens binding of MurR to the operator (By similarity) HVZ24_06385 ENOG4105I7Z Short-chain dehydrogenase reductase Sdr HVZ24_06390 ENOG4108J2H Sulfate ABC transporter periplasmic sulfate-binding protein HVZ24_06395 ENOG4108I5D sulfate abc transporter HVZ24_06400 ENOG4105ECW sulfate abc transporter HVZ24_06405 ENOG4108IJ6 ABC transporter HVZ24_06410 ENOG4105C6T cysteine synthase HVZ24_06415 ENOG4105WEC Molybdate metabolism regulator HVZ24_06420 ENOG4105M0Y HVZ24_06430 ENOG4105C5Y PTS System HVZ24_06435 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) HVZ24_06445 ENOG4105C6T cysteine synthase HVZ24_06460 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) HVZ24_06465 ENOG4105VRT cytoplasmic protein HVZ24_06470 ENOG4105DHU Bile acid HVZ24_06475 ENOG4108M0I Transcriptional regulator HVZ24_06480 ENOG4108NFH Sugar hydrolase HVZ24_06485 ENOG4107U5R The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity) HVZ24_06490 ENOG4105EAA nucleoside HVZ24_06500 ENOG4105CN8 Transcriptional regulator HVZ24_06535 ENOG4105GXM Putative transcription regulator (DUF1323) HVZ24_06540 ENOG4105HZG regulatoR HVZ24_06555 ENOG4108KMM Diguanylate cyclase HVZ24_06560 ENOG4105D9N nucleoside HVZ24_06570 ENOG4109076 Conserved Protein HVZ24_06575 ENOG4105VCT ion-transport protein YfeO HVZ24_06585 ENOG4105R6B The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane (By similarity) HVZ24_06590 ENOG410863U PTS System HVZ24_06595 ENOG4105DC7 peptidase M24 HVZ24_06600 ENOG4105CN9 Peptidase m42 family protein HVZ24_06605 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) HVZ24_06610 ENOG4108CIP transcriptional regulator HVZ24_06615 ENOG4105DY9 regulatoR HVZ24_06620 ENOG4108HRK Histidine kinase HVZ24_06625 ENOG4105CHM Aminotransferase HVZ24_06635 ENOG4105D1S lipid A biosynthesis HVZ24_06640 ENOG4105W9M Membrane HVZ24_06650 ENOG4108V08 YfdX protein HVZ24_06660 ENOG4105CFN oxalyl-CoA decarboxylase HVZ24_06665 ENOG4108N2Y auxin Efflux HVZ24_06670 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F HVZ24_06675 ENOG4105BZU Histidine kinase HVZ24_06680 ENOG4108WQH regulatoR HVZ24_06685 ENOG4105CW7 secretion protein, HlyD family HVZ24_06690 ENOG4105C0R drug resistance transporter emrb qaca subfamily HVZ24_06695 ENOG4105BZC d-serine deaminase HVZ24_06700 ENOG4105C6Z Gluconate HVZ24_06705 ENOG4105W8I Transcriptional regulator HVZ24_06765 ENOG4105S64 Formate nitrite transporter HVZ24_06770 ENOG410903C (LipO)protein HVZ24_06780 ENOG4105CKF membrane protein involved in aromatic hydrocarbon degradation HVZ24_06785 ENOG4105KZW UPF0381 protein HVZ24_06790 ENOG4105CHU acetyl-coa acetyltransferase HVZ24_06795 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase HVZ24_06800 ENOG4108BY2 phosphohistidine phosphatase HVZ24_06810 ENOG4106PG1 outer membrane usher protein HVZ24_06815 ENOG4108FZ9 Chaperone HVZ24_06820 ENOG4105NEV Fimbrial HVZ24_06825 ENOG4105UGQ Fimbrial HVZ24_06830 ENOG4105US4 fimbrial-like protein yfcP HVZ24_06845 ENOG4105C76 Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity) HVZ24_06855 ENOG4105HPZ Involved in the removal of murein from the sacculus. May also facilitate integration of nascent murein strands into the sacculus by cleaving the peptide bonds between neighboring strands in mature murein (By similarity) HVZ24_06860 ENOG4105EJ9 Membrane HVZ24_06865 ENOG4108BPE -transporting atpase HVZ24_06870 ENOG4105MH2 YfcL protein HVZ24_06875 ENOG4105CWG Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity) HVZ24_06880 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) HVZ24_06885 ENOG4105F9N Major Facilitator Superfamily HVZ24_06890 ENOG4106WZ1 flagella biosynthesis regulator HVZ24_06895 ENOG4105CJ0 Catalyzes the oxidation of erythronate-4-phosphate to 3- hydroxy-2-oxo-4-phosphonooxybutanoate (By similarity) HVZ24_06900 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) HVZ24_06910 ENOG4105DQR SNARE associated Golgi HVZ24_06920 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase HVZ24_06925 ENOG4108S3P Sporulation domain protein HVZ24_06930 ENOG4105E96 Colicin v production protein HVZ24_06935 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase HVZ24_06940 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase HVZ24_06945 ENOG4105E89 ABC transporter HVZ24_06950 ENOG4105E89 ABC transporter HVZ24_06955 ENOG4105DSP amino acid AbC transporter HVZ24_06960 ENOG4106YG3 ABC transporter HVZ24_06965 ENOG4108JEH abc transporter atp-binding protein HVZ24_06970 ENOG4105DNE Transposase HVZ24_06975 ENOG4105ECP epimerase HVZ24_06980 ENOG4105KKP D-erythro-7,8-dihydroneopterin triphosphate 2'-epimerase HVZ24_06985 ENOG4105CYM Glutathione S-transferase HVZ24_06990 ENOG4108SHQ Glutathione S-transferase HVZ24_06995 ENOG4108RE9 Phosphodiesterase HVZ24_07000 ENOG4105PTV Nudix Hydrolase HVZ24_07005 ENOG4105CSX c4-dicarboxylate anaerobic carrier HVZ24_07010 ENOG4105C6K Malic enzyme HVZ24_07015 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) HVZ24_07025 ENOG4105XWI UPF0304 protein HVZ24_07030 ENOG4105EVE HAD-superfamily hydrolase subfamily IA variant 3 HVZ24_07035 ENOG4107QWE )-transporter HVZ24_07040 ENOG4105DK2 UPF0207 protein HVZ24_07045 ENOG4105CHM Aminotransferase HVZ24_07050 ENOG4107NQ8 LysR family Transcriptional regulator HVZ24_07065 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HVZ24_07070 ENOG4105GKE subunit e HVZ24_07075 ENOG4107QIZ NADH dehydrogenase HVZ24_07080 ENOG4107R0R NADH dehydrogenase subunit g HVZ24_07095 ENOG4107UFS subunit j HVZ24_07105 ENOG4105D65 subunit l HVZ24_07110 ENOG4105C8S subunit m HVZ24_07120 ENOG4106HDC HVZ24_07125 ENOG4106EES HVZ24_07130 ENOG4105ZD8 HVZ24_07135 ENOG4105GDX Domain of unknown function (DUF1877) HVZ24_07140 ENOG4107VAM peptidase, m28 HVZ24_07145 ENOG4105CP2 von willebrand factor, type a HVZ24_07150 ENOG4105Z6G Protease that can act as an efficient and specific deubiquitinating enzyme in vitro. Does not possess desumoylating and deneddylating activities. The physiological substrate is HVZ24_07160 ENOG4107YB6 acetyltransferase, (GNAT) family HVZ24_07165 ENOG4105TNS Conserved Protein HVZ24_07170 ENOG4105E4F Isochorismate synthase HVZ24_07180 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) HVZ24_07185 ENOG4108IPT Naphthoate synthase HVZ24_07190 ENOG4105DNI Converts SHCHC to OSB (By similarity) HVZ24_07195 ENOG4105CEY Amp-dependent synthetase and ligase HVZ24_07200 ENOG4106GZG polymyxin resistance protein B HVZ24_07205 ENOG4105U65 Translocates 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol (alpha-L-Ara4N-phosphoundecaprenol) from the cytoplasmic to the periplasmic side of the inner membrane (By similarity) HVZ24_07215 ENOG4105SA9 Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity) HVZ24_07225 ENOG4105C3I Nad-dependent epimerase dehydratase HVZ24_07240 ENOG4108WMR Catalyzes the dephosphorylation of heptose(II) of the outer membrane lipopolysaccharide core (By similarity) HVZ24_07245 ENOG4108RJ7 Catalyzes the hydrolysis of nucleoside triphosphates, with a preference for pyrimidine deoxynucleoside triphosphates (dUTP, dTTP and dCTP) (By similarity) HVZ24_07250 ENOG4108UII YfaZ family HVZ24_07255 ENOG4108EWA cinA-like protein HVZ24_07260 ENOG4107258 Transcriptional regulator HVZ24_07265 ENOG4105CXK mandelate racemase muconate lactonizing HVZ24_07270 ENOG4105CSP Major Facilitator Superfamily HVZ24_07285 ENOG4105DNE Transposase HVZ24_07290 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) HVZ24_07295 ENOG4108KJ0 anaerobic glycerol-3-phosphate dehydrogenase, subunit B HVZ24_07300 ENOG4107R5Y anaerobic glycerol-3-phosphate dehydrogenase, subunit A HVZ24_07305 ENOG4105CXY transporter HVZ24_07310 ENOG4106MZZ glycerophosphoryl diester phosphodiesterase HVZ24_07320 ENOG4105FQR PH-inducible protein involved in stress response HVZ24_07325 ENOG4105XPH Ferredoxin HVZ24_07330 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HVZ24_07335 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HVZ24_07340 ENOG4107GHC outer membrane autotransporter HVZ24_07350 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HVZ24_07355 ENOG4107FKF Uncharacterized protein conserved in bacteria (DUF2138) HVZ24_07360 ENOG4108QJJ Protein of unknown function (DUF1175) HVZ24_07365 ENOG4107S52 alpha-2-macroglobulin domain protein HVZ24_07370 ENOG41081SK signal peptide protein HVZ24_07375 ENOG4105EDV vault protein HVZ24_07380 ENOG4105CHU acetyl-coa acetyltransferase HVZ24_07385 ENOG4105CRW Short chain fatty acid transporter HVZ24_07390 ENOG4107QNJ CoA-transferase subunit B HVZ24_07395 ENOG4107QP7 CoA-transferase subunit A HVZ24_07400 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family HVZ24_07405 ENOG4105BZU Histidine kinase HVZ24_07410 ENOG4105BZU Histidine kinase HVZ24_07415 ENOG41068CG regulatoR HVZ24_07420 ENOG4105E3G Phosphotransfer intermediate protein in two-component regulatory system with RcsBC HVZ24_07425 ENOG4105FCK Membrane HVZ24_07430 ENOG4105CJ2 (LipO)protein HVZ24_07435 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) HVZ24_07440 ENOG4105CF1 Alkylated DNA repair protein HVZ24_07445 ENOG4105IBP Cyclic peptide transporter HVZ24_07450 ENOG4105DWT malate dehydrogenase (quinone) HVZ24_07465 ENOG4108ZNS ferredoxin-type protein NapF HVZ24_07470 ENOG41061Q0 Assembly protein for periplasmic nitrate reductase HVZ24_07475 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) HVZ24_07480 ENOG4108BGM Quinol dehydrogenase periplasmic component HVZ24_07485 ENOG4105GXZ Ferredoxin-type protein NapH HVZ24_07490 ENOG4108ZMS Electron transfer subunit of the periplasmic nitrate reductase complex NapAB (By similarity) HVZ24_07495 ENOG4105CUW cytochrome C-TYPE protein HVZ24_07500 ENOG4107EV4 once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system (By similarity) HVZ24_07505 ENOG4105CA5 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes (By similarity) HVZ24_07510 ENOG41060IM Heme exporter protein HVZ24_07515 ENOG4105X3C heme exporter protein HVZ24_07525 ENOG4105DA4 cytochrome c-type biogenesis protein HVZ24_07530 ENOG4107QX9 Thiol disulfide interChange protein HVZ24_07535 ENOG4105KWW Biogenesis protein HVZ24_07540 ENOG4105WH1 Two component transcriptional regulator luxr family HVZ24_07555 ENOG4105E68 Sulfatase HVZ24_07575 ENOG4105CFI type iii restriction protein res subunit HVZ24_07580 ENOG4105I08 Pseudouridine synthase HVZ24_07585 ENOG4105C2C drug resistance transporter, Bcr CflA HVZ24_07590 ENOG4105HG6 HVZ24_07595 ENOG4108JQ5 ABC transporter HVZ24_07600 ENOG4108IYQ Binding-protein-dependent transport systems inner membrane component HVZ24_07605 ENOG4108I5X binding-protein-dependent transport systems inner membrane Component HVZ24_07610 ENOG4105E43 Extracellular solute-binding protein, family 5 HVZ24_07615 ENOG4105CXC rtn protein HVZ24_07620 ENOG4107TT5 NLP P60 protein HVZ24_07625 ENOG41076MN Phosphoesterase, PA-phosphatase related HVZ24_07630 ENOG4105CKI cobalamin synthesis protein HVZ24_07635 ENOG4105DEI Mannitol dehydrogenase HVZ24_07645 ENOG4105KRS Proteinase inhibitor HVZ24_07650 ENOG4105S8Q sugar efflux transporter HVZ24_07655 ENOG4105DTZ bifunctional PTS system fructose-specific transporter subunit IIA HPr protein HVZ24_07660 ENOG4105DE4 1-phosphofructokinase HVZ24_07665 ENOG4105DM4 PTS System HVZ24_07670 ENOG4105DD7 kinase (PfkB family HVZ24_07675 ENOG4105D53 Catalyzes the hydrolysis of pseudouridine 5'-phosphate (PsiMP) to ribose 5-phosphate and uracil (By similarity) HVZ24_07680 ENOG4105D9N nucleoside HVZ24_07685 ENOG4108Y4K DNA-binding transcriptional activator HVZ24_07695 ENOG4105D9N nucleoside HVZ24_07700 ENOG4105DD7 kinase (PfkB family HVZ24_07705 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) HVZ24_07710 ENOG4105HMI Membrane HVZ24_07715 ENOG4105DUM transcriptional regulator, lysR family HVZ24_07720 ENOG4108IQI permease HVZ24_07725 ENOG4105D05 Receptor HVZ24_07740 ENOG4105DHF Membrane HVZ24_07745 ENOG41060NJ transcriptional regulator HVZ24_07750 ENOG4105EMA Periplasmic binding protein LacI transcriptional regulator HVZ24_07755 ENOG4105C2J ABC transporter HVZ24_07760 ENOG4108HWV )-transporter HVZ24_07765 ENOG4107SJI Dehydrogenase HVZ24_07770 ENOG4105BZ8 glutamate synthase HVZ24_07775 ENOG4105Y9N Membrane HVZ24_07780 ENOG4107GZ4 SanA protein HVZ24_07790 ENOG41067MG lrgb family HVZ24_07800 ENOG4105FBT Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity) HVZ24_07810 ENOG4105ETP RND efflux system, outer membrane lipoprotein HVZ24_07815 ENOG4105H9W Short-chain dehydrogenase reductase Sdr HVZ24_07820 ENOG4105KHU inner membrane protein YohD HVZ24_07825 ENOG41069YE inner membrane protein yohC HVZ24_07830 ENOG41061WM D-Alanyl-D-Alanine HVZ24_07835 ENOG4105CXG d-lactate dehydrogenase HVZ24_07840 ENOG4107QK4 glycoside hydrolase, family 3 domain protein HVZ24_07845 ENOG4107SI7 Substrate-binding region of abc-type glycine betaine transport system HVZ24_07850 ENOG4107T5X Binding-protein-dependent transport systems, inner membrane component HVZ24_07855 ENOG4108IJ8 ABC transporter HVZ24_07860 ENOG4105WJV Binding-protein-dependent transport systems, inner membrane component HVZ24_07870 ENOG4108XDN Transcriptional regulator HVZ24_07875 ENOG4108HRK Histidine kinase HVZ24_07880 ENOG4108NEV two component transcriptional regulator, LytTR family HVZ24_07885 ENOG4108W15 Protein of unknown function (DUF1456) HVZ24_07890 ENOG4108YCW (LipO)protein HVZ24_07895 ENOG410903U zinc ion binding HVZ24_07900 ENOG4105DEG Vwa containing coxe family protein HVZ24_07905 ENOG4105RD5 HVZ24_07910 ENOG4105KKX ATPase associated with various cellular activities aaa_5 HVZ24_07920 ENOG4108KDT Molybdate metabolism regulator HVZ24_07925 ENOG4108KDT Molybdate metabolism regulator HVZ24_07930 ENOG4108KDT Molybdate metabolism regulator HVZ24_07940 ENOG4105D1F ATP-binding protein HVZ24_07945 ENOG41067AK Protein of unknown function (DUF2574) HVZ24_07950 ENOG41063W2 Fimbrial protein HVZ24_07955 ENOG4108MQF Chaperone HVZ24_07975 ENOG410662B Type-1 fimbrial protein HVZ24_07980 ENOG4108Z1S Influences nickel and cobalt homeostasis. May act by modulating RcnA-mediated export of these ions to avoid excess efflux. Not involved in nickel import and does not bind nickel or cobalt ions directly HVZ24_08015 ENOG4105DWF phosphomethylpyrimidine kinase HVZ24_08020 ENOG4108UQ1 hydrolase, family 25 HVZ24_08025 ENOG4105FDP GntR family transcriptional regulator HVZ24_08030 ENOG4108TFM Kinase, PfkB family HVZ24_08035 ENOG4108KD5 ADP-ribosylation crystallin J1 HVZ24_08040 ENOG4105EAA nucleoside HVZ24_08045 ENOG4105EIE fructose-bisphosphate aldolase HVZ24_08060 ENOG41082GB PTS system galactitol-specific transporter subunit IIA HVZ24_08065 ENOG41090UW PTS System HVZ24_08070 ENOG4105DT3 PTS system, galactitol-specific IIc component HVZ24_08075 ENOG4107WTH Galactitol-1-phosphate dehydrogenase HVZ24_08090 ENOG41076Z6 Uncharacterized protein yegR HVZ24_08150 ENOG4105ZTC transcriptional activator, Ogr delta HVZ24_08155 ENOG4105CFP Peptidase U32 HVZ24_08165 ENOG4105X54 addiction module antidote protein HVZ24_08170 ENOG4105KWI UPF0339 protein HVZ24_08175 ENOG4105E3W Two component transcriptional regulator (Winged helix family HVZ24_08180 ENOG4105EB3 Histidine kinase HVZ24_08215 ENOG4108M24 von Willebrand factor, type A HVZ24_08220 ENOG4105UM3 Inherit from NOG: serine threonine phosphoprotein phosphatase HVZ24_08225 ENOG4106E1W protein with protein kinase and helix-hairpin-helix DNA-binding HVZ24_08230 ENOG4105R8A Heat shock protein HVZ24_08235 ENOG4105D03 DNA-3-methyladenine glycosylase II HVZ24_08240 ENOG4105BZU Histidine kinase HVZ24_08245 ENOG4105DBI uridine monophosphokinase HVZ24_08255 ENOG4108GAE asmA family HVZ24_08260 ENOG4105EE5 Membrane protein terC HVZ24_08265 ENOG4105DAY polysaccharide export protein HVZ24_08270 ENOG4105KJF protein tyrosine phosphatase HVZ24_08275 ENOG4105D75 Capsular exopolysaccharide family HVZ24_08280 ENOG41090RK glycosyl transferase HVZ24_08285 ENOG41068PY Colanic acid biosynthesis acetyltransferase wcaB HVZ24_08290 ENOG4107RXY Glycosyl transferase HVZ24_08295 ENOG4108NYJ Colanic acid HVZ24_08300 ENOG4105ECJ Glycosyl Transferase HVZ24_08305 ENOG4108Z90 colanic acid biosynthesis acetyltransferase wcaF HVZ24_08310 ENOG4105C0K Gdp-mannose 4,6-dehydratase HVZ24_08315 ENOG4105C30 Nad-dependent epimerase dehydratase HVZ24_08320 ENOG4105FGF GDP-mannose mannosyl hydrolase HVZ24_08325 ENOG4106CD9 glycosyl transferase group 1 HVZ24_08330 ENOG4105CJT Mannose-1-phosphate guanylyltransferase HVZ24_08335 ENOG4107QKV phosphomannomutase HVZ24_08340 ENOG4105D3Q Sugar transferase HVZ24_08345 ENOG4105PSV Polysaccharide Biosynthesis Protein HVZ24_08350 ENOG4105C74 pyruvyl transferase HVZ24_08355 ENOG4107T8Q Glycosyl transferase (Group 1 HVZ24_08360 ENOG4105G1A colanic acid biosynthesis protein HVZ24_08365 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase HVZ24_08370 ENOG4105C1B dTDP-glucose 4-6-dehydratase HVZ24_08375 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase HVZ24_08380 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) HVZ24_08385 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase HVZ24_08415 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase HVZ24_08430 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) HVZ24_08435 ENOG4105C6Y Udp-glucose 6-dehydrogenase HVZ24_08440 ENOG4108KPN Confers a modal distribution of chain length on the O- antigen component of lipopolysaccharide (LPS). Gives rise to a reduced number of short chain molecules and increases in numbers of longer molecules, with a modal value of 13 (in strain O111 M92) and of 17 (in strain K12) HVZ24_08460 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) HVZ24_08465 ENOG4105ECC imidazole-glycerol-phosphate dehydratase HVZ24_08470 ENOG4105CIH Imidazole acetol-phosphate transaminase HVZ24_08475 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) HVZ24_08490 ENOG4105VTW prevent-host-death family HVZ24_08495 ENOG4105KRQ Addiction module toxin, Txe YoeB family HVZ24_08500 ENOG4107SRH Nad-dependent epimerase dehydratase HVZ24_08505 ENOG4105EQ1 Transcriptional regulator HVZ24_08515 ENOG4105CUB amino acid HVZ24_08520 ENOG4105CUC YeeE YedE family protein HVZ24_08530 ENOG4105CJB Exodeoxyribonuclease I HVZ24_08535 ENOG4105DZ1 carboxypeptidase HVZ24_08545 ENOG4105DR8 Membrane HVZ24_08580 ENOG4105MAW Antitoxin component of a toxin-antitoxin (TA) module. Labile antitoxin that counteracts the effect of the CbtA (YeeV) toxin. It does not bind to the cognate toxin but instead binds to MreB and FtsZ (the toxin targets), enhancing their polymerization by forming higher-order bundles HVZ24_08590 ENOG4108YGG dna repair protein HVZ24_08595 ENOG4105MFG Antirestriction protein HVZ24_08640 ENOG4108YXQ IS66 Orf2 family protein HVZ24_08645 ENOG4105E5H Transposase HVZ24_08695 ENOG41080QX K07048 phosphotriesterase-related protein HVZ24_08710 ENOG4108RVA ribokinase HVZ24_08720 ENOG4108YZT Adenosylcobinamide kinase HVZ24_08735 ENOG4108PXI ErfK YbiS YcfS YnhG HVZ24_08745 ENOG4106P55 Transcriptional regulator HVZ24_08750 ENOG4107R11 Transcriptional regulator HVZ24_08760 ENOG4105UQX Mate efflux family protein HVZ24_08770 ENOG4105CDY transcriptional regulatory protein HVZ24_08775 ENOG4105FYV Amp nucleosidase HVZ24_08780 ENOG4105CSH Transporter HVZ24_08800 ENOG4105CNA YD repeat protein HVZ24_08815 ENOG4108SER Transposase HVZ24_08845 ENOG4108VKM cytochrome b561 HVZ24_08850 ENOG4108MEK Metal-binding protein YodA HVZ24_08860 ENOG4105CCD The exact function is not known. Can catalyze the reduction of a variety of substrates like dimethyl sulfoxide, trimethylamine N-oxide, phenylmethyl sulfoxide and L-methionine sulfoxide. Cannot reduce cyclic N-oxides. Shows no activity as sulfite oxidase (By similarity) HVZ24_08865 ENOG4105VT2 5-hydroxyisourate hydrolase HVZ24_08870 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HVZ24_08875 ENOG4107ZY3 Histidine kinase HVZ24_08885 ENOG4105ZIT Porin Gram-negative type HVZ24_08890 ENOG4105Y0K Inner membrane protein YedR HVZ24_08895 ENOG4105EST Metal Dependent Phosphohydrolase HVZ24_08900 ENOG4105DVF Cytosine-specific methyltransferase HVZ24_08905 ENOG41090BB DNA mismatch endonuclease (vsr) HVZ24_08910 ENOG4105FDR Membrane HVZ24_08915 ENOG4105CKW Inner membrane protein yedI HVZ24_08920 ENOG4105VNZ cytoplasmic protein HVZ24_08935 ENOG4105YX3 cellular response to acidity HVZ24_08945 ENOG4107TKS colanic acid capsular biosynthesis activation protein A HVZ24_08950 ENOG4105D19 Role in flagellar biosynthesis (By similarity) HVZ24_08960 ENOG4105CN7 Flagellar biosynthetic protein FliP HVZ24_08965 ENOG4105K0P flagellar biosynthesis protein HVZ24_08970 ENOG4105DD5 Flagellar motor switch protein HVZ24_08975 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) HVZ24_08980 ENOG4107ZI8 flagellar basal body-associated protein flil HVZ24_08985 ENOG4105WF4 Flagellar hook-length control protein HVZ24_08990 ENOG4105GSA Flagellar export protein flij HVZ24_08995 ENOG4108JIR Flagellum-specific ATP synthase HVZ24_09000 ENOG41090PJ Flagellar assembly protein HVZ24_09005 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) HVZ24_09010 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) HVZ24_09015 ENOG4105VQ0 flagellar hook-basal body complex protein fliE HVZ24_09020 ENOG4108RAV Conserved protein HVZ24_09030 ENOG41066VF YeeE YedE family protein HVZ24_09035 ENOG4108W9D (LipO)protein HVZ24_09040 ENOG4105E5K Alpha-amylase HVZ24_09050 ENOG4105MQ3 flagellar protein FliS HVZ24_09055 ENOG4105DTS flagellar hook-associated HVZ24_09060 ENOG4105I03 Flagellin HVZ24_09065 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HVZ24_09070 ENOG4108M9K flagella biosynthesis protein FliZ HVZ24_09075 ENOG4105EAB amino acid AbC transporter HVZ24_09080 ENOG4105K6H D-cysteine desulfhydrase HVZ24_09085 ENOG4105E5Q amino acid AbC transporter HVZ24_09090 ENOG4105CDA abc transporter atp-binding protein HVZ24_09095 ENOG4105VJY transcriptional regulator HVZ24_09100 ENOG4105XVG cytoplasmic protein HVZ24_09110 ENOG4105WH1 Two component transcriptional regulator luxr family HVZ24_09140 ENOG4106RHG Yeca family HVZ24_09145 ENOG4105E0U tyrosine-specific transport protein HVZ24_09150 ENOG4105VVZ metal-binding protein HVZ24_09155 ENOG41090A1 ferritin HVZ24_09160 ENOG4105P23 (LipO)protein HVZ24_09170 ENOG4105N4N Protein of unknown function (DUF2766) HVZ24_09175 ENOG4108UEC Ferritin-like protein HVZ24_09180 ENOG4105DMK Periplasmic binding protein LacI transcriptional regulator HVZ24_09185 ENOG4105C2J ABC transporter HVZ24_09190 ENOG4105CNN ABC, transporter HVZ24_09195 ENOG4108K4C ec 3.1.3.12 HVZ24_09205 ENOG4108VA4 Universal stress protein HVZ24_09215 ENOG4106CIA Functions in complex with FlhD as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region HVZ24_09220 ENOG4107RD7 Flagellar Motor Protein, MotA HVZ24_09225 ENOG4105ER2 Ompa motb domain protein HVZ24_09230 ENOG4105CBS Chea signal transduction histidine kinase HVZ24_09235 ENOG4108V3W Chemotaxis protein, CheW HVZ24_09240 ENOG4105C8Q Methyl-accepting chemotaxis HVZ24_09245 ENOG4105C8Q Methyl-accepting chemotaxis HVZ24_09250 ENOG4105BZU Histidine kinase HVZ24_09255 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) HVZ24_09260 ENOG4108VYJ response regulator receiver protein HVZ24_09265 ENOG4108KCC Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P) (By similarity) HVZ24_09270 ENOG4105D00 flagellar biosynthetic protein flhB HVZ24_09275 ENOG4105D7B Flagellar biosynthesis protein flha HVZ24_09280 ENOG4105W13 flagellar protein HVZ24_09290 ENOG4105C75 arginyL-tRNA synthetase HVZ24_09295 ENOG4106ZCM YecM protein HVZ24_09305 ENOG4105CUW cytochrome C-TYPE protein HVZ24_09310 ENOG4107QY8 reductase HVZ24_09320 ENOG4105DA6 Catalyzes the conversion of 5-methoxyuridine (mo5U) to uridine-5-oxyacetic acid (cmo5U) at position 34 in tRNA. May also participate in the methylation of uridine-5-oxyacetic acid (cmo5U) to uridine-5-oxyacetic acid methyl ester (mcmo5U) (By similarity) HVZ24_09325 ENOG4105WJG Glutathione HVZ24_09330 ENOG41081XQ Conserved Protein HVZ24_09335 ENOG4105D3W isochorismatase HVZ24_09345 ENOG4108TIT dATP pyrophosphohydrolase HVZ24_09350 ENOG4105CDY transcriptional regulatory protein HVZ24_09360 ENOG4107S01 Repressor protein MetJ HVZ24_09380 ENOG4105FAV ABC, transporter HVZ24_09390 ENOG4105NXV High-affinity zinc uptake system protein HVZ24_09395 ENOG4105DR5 peptidase HVZ24_09400 ENOG4105NWR lipid A biosynthesis (Kdo)2-(Lauroyl)-lipid IVA acyltransferase HVZ24_09405 ENOG4105CA9 Pyruvate kinase HVZ24_09410 ENOG4106KNT transcriptional regulator HVZ24_09415 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase HVZ24_09420 ENOG4105C01 Dihydroxy-acid dehydratase HVZ24_09425 ENOG4108UHU Aldolase HVZ24_09430 ENOG4108HH9 Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR HVZ24_09435 ENOG4105X2V dna damage-inducible protein HVZ24_09445 ENOG4108Q2J Inner membrane protein YebE HVZ24_09450 ENOG4105CUG Oligopeptidase b HVZ24_09455 ENOG4105UMD exodeoxyribonuclease X HVZ24_09460 ENOG4108YGA nitrilase cyanide hydratase and apolipoprotein n-acyltransferase HVZ24_09465 ENOG4105MPK DNA polymerase III subunit theta HVZ24_09470 ENOG4105FXM Copper resistance protein HVZ24_09475 ENOG4108PNC copper resistance HVZ24_09480 ENOG4105NKT exported protein HVZ24_09485 ENOG4108R1E Serine threonine protein phosphatase 1 HVZ24_09490 ENOG4105UVW uncharacterized protein yebW HVZ24_09495 ENOG4105WT8 Protein of unknown function (DUF1480) HVZ24_09500 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B HVZ24_09505 ENOG4105DY2 Paraquat-inducible protein b HVZ24_09510 ENOG4105H2K paraquat-inducible protein a HVZ24_09515 ENOG4108ZGC gaf domain protein HVZ24_09520 ENOG41073DY may be a structural element that influences the osmotic activation of ProP at a post-translational level (By similarity) HVZ24_09525 ENOG4105CN1 protease HVZ24_09530 ENOG4105D0M Protease HtpX homolog HVZ24_09535 ENOG4105C0R drug resistance transporter emrb qaca subfamily HVZ24_09540 ENOG4105J4Q Transcriptional regulator HVZ24_09545 ENOG4105TIK HVZ24_09555 ENOG4105Q3Y exported protein HVZ24_09570 ENOG4105DHI Methyltransferase HVZ24_09585 ENOG4105F3R pts system mannose fructose sorbose family iid HVZ24_09590 ENOG4105ETZ PTS System HVZ24_09595 ENOG4105DAS pts system HVZ24_09600 ENOG4105EE5 Membrane protein terC HVZ24_09605 ENOG4107XTP (EAL) domain protein HVZ24_09610 ENOG4105EJQ L-serine dehydratase HVZ24_09615 ENOG4105P8F nudix hydrolase HVZ24_09620 ENOG4105CRQ synthase (Component I) HVZ24_09630 ENOG4105V2F Uncharacterized protein yoac HVZ24_09635 ENOG4105M4H endoribonuclease L-psp HVZ24_09640 ENOG4105DVT helicase HVZ24_09645 ENOG41072GX Peptidase M22 Glycoprotease HVZ24_09650 ENOG4105Y4Z Outer Membrane Lipoprotein HVZ24_09655 ENOG4105CEY Amp-dependent synthetase and ligase HVZ24_09660 ENOG4105ZIE Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity) HVZ24_09665 ENOG4105E3J oxidoreductase HVZ24_09670 ENOG4105DVW rieske (2Fe-2S) HVZ24_09680 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) HVZ24_09685 ENOG4105EJC lysr family transcriptional regulator HVZ24_09695 ENOG4108YS1 cytoplasmic protein HVZ24_09700 ENOG4105YP6 Domain of unknown function (DUF1869) HVZ24_09705 ENOG4105Y3U Transglycosylase-associated protein HVZ24_09715 ENOG4106G4W HVZ24_09720 ENOG410620I Diguanylate cyclase HVZ24_09725 ENOG4105UCG Domain of unknown function (DUF333) HVZ24_09730 ENOG4105K78 MarR family Transcriptional regulator HVZ24_09735 ENOG4105DJ2 Major Facilitator Superfamily HVZ24_09740 ENOG4105R1U AraC Family Transcriptional Regulator HVZ24_09755 ENOG4108KXH Ybak prolyl-tRNA synthetase associated HVZ24_09760 ENOG4108KHP Diguanylate cyclase HVZ24_09765 ENOG4106KTS Inner membrane protein yeaI HVZ24_09770 ENOG4106AKX UPF0229 protein HVZ24_09775 ENOG4105CYN Serine protein kinase HVZ24_09780 ENOG4105GNX MltA-interacting MipA family protein HVZ24_09785 ENOG4105CV8 reductase HVZ24_09790 ENOG4105DSB aldose 1-epimerase HVZ24_09795 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase HVZ24_09805 ENOG4105VUT cytoplasmic protein HVZ24_09810 ENOG4105CPQ Dehydrogenase HVZ24_09815 ENOG4107TE1 transport protein HVZ24_09820 ENOG4105CPQ Dehydrogenase HVZ24_09825 ENOG4105D2N Aldolase HVZ24_09830 ENOG4107UH8 sugar kinase HVZ24_09835 ENOG4105CPC Aldo Keto reductase HVZ24_09840 ENOG4105E98 transcriptional regulator DeoR family HVZ24_09845 ENOG4108KUU Inner membrane metabolite transport protein ydjE HVZ24_09850 ENOG4108RWI nicotinamidase HVZ24_09855 ENOG4105HDK L-asparaginase HVZ24_09860 ENOG4105D07 Signal peptide peptidase, SppA HVZ24_09865 ENOG41069NU Nitroreductase HVZ24_09875 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) HVZ24_09880 ENOG41065FB inner membrane protein ynji HVZ24_09885 ENOG4105D82 Glutamate dehydrogenase HVZ24_09890 ENOG4105MTM Protein of unknown function (DUF1496) HVZ24_09895 ENOG4105M6F mutator MutT protein HVZ24_09900 ENOG4108T9J Cdp-alcohol phosphatidyltransferase HVZ24_09905 ENOG4107RM6 sulfurtransferase HVZ24_09910 ENOG4108VGW abc transporter atp-binding protein HVZ24_09915 ENOG4105CXZ ABC transporter, permease HVZ24_09920 ENOG4105VNH ABC transporter solute-binding protein HVZ24_09925 ENOG4107ZN8 Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) HVZ24_09930 ENOG4108N5C SNARE associated Golgi protein-related protein HVZ24_09935 ENOG4108KCW iron-sulfur cluster binding HVZ24_09940 ENOG4108RSN SNARE associated Golgi HVZ24_09945 ENOG4105CGK Exodeoxyribonuclease III HVZ24_09960 ENOG4105C26 Dehydrogenase HVZ24_09965 ENOG4105EY2 Catalyzes the hydrolysis of N(2)-succinylarginine into N(2)-succinylornithine, ammonia and CO(2) (By similarity) HVZ24_09975 ENOG4108SPG Periplasmic Protein HVZ24_09985 ENOG4105DKD Incises the DNA at the 3' side of a lesion during nucleotide excision repair. Incises the DNA farther away from the lesion than UvrC. Not able to incise the 5' site of a lesion. When a lesion remains because UvrC is not able to induce the 3' incision, Cho incises the DNA. Then UvrC makes the 5' incision. The combined action of Cho and UvrC broadens the substrate range of nucleotide excision repair (By similarity) HVZ24_09995 ENOG4105KKI DNA-binding transcriptional activator OsmE HVZ24_10000 ENOG4105VZJ PTS System HVZ24_10005 ENOG4105CK1 PTS System HVZ24_10010 ENOG4105VCP PTS System HVZ24_10015 ENOG4105EZV Transcriptional regulator HVZ24_10020 ENOG4105F8D glycoside hydrolase family 4 HVZ24_10025 ENOG410901P UPF0249 protein HVZ24_10030 ENOG4105CH6 catalase HVZ24_10045 ENOG4108ETY sodium dicarboxylate symporter HVZ24_10050 ENOG4107K5X Membrane-bound metal-dependent hydrolase HVZ24_10055 ENOG4107UW8 HAD-superfamily hydrolase subfamily IA variant 3 HVZ24_10060 ENOG4107PN8 YfeABCD locus regulator HVZ24_10070 ENOG4105P10 Uncharacterized protein ydiZ HVZ24_10075 ENOG4105DE4 1-phosphofructokinase HVZ24_10080 ENOG4108NE3 Salt-induced outer membrane protein HVZ24_10100 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) HVZ24_10105 ENOG41082NX 50s ribosomal protein l35 HVZ24_10125 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) HVZ24_10140 ENOG4108V06 Glutathione peroxidase HVZ24_10150 ENOG4108QBX (LipO)protein HVZ24_10155 ENOG4108TC0 Diguanylate phosphodiesterase HVZ24_10160 ENOG4105CNG UPF0061 protein HVZ24_10170 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) HVZ24_10180 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) HVZ24_10185 ENOG4105CEY Amp-dependent synthetase and ligase HVZ24_10190 ENOG41090P5 ferredoxin-like protein HVZ24_10195 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase HVZ24_10200 ENOG4105C10 Electron transfer flavoprotein HVZ24_10205 ENOG4105CV7 Electron transfer flavoprotein HVZ24_10210 ENOG4105W4W Transcriptional regulator HVZ24_10215 ENOG4105C1G acyl-Coa dehydrogenase HVZ24_10220 ENOG4107R0K CoA transferase having broad substrate specificity for short-chain acyl-CoA thioesters with the activity decreasing when the length of the carboxylic acid chain exceeds four carbons (By similarity) HVZ24_10235 ENOG4105EMV Major Facilitator HVZ24_10240 ENOG4105EMV Major Facilitator HVZ24_10245 ENOG4105SUA Ydil protein HVZ24_10255 ENOG4105IPI Membrane HVZ24_10260 ENOG4105CQB FAD linked oxidase domain protein HVZ24_10265 ENOG4105KA0 thioesterase Superfamily protein HVZ24_10270 ENOG410671Z uncharacterized protein ydiH HVZ24_10275 ENOG4108Z4V iron-sulfur cluster assembly HVZ24_10280 ENOG4105DIW FeS assembly protein SUFB HVZ24_10285 ENOG4105C3K feS assembly ATPase SufC HVZ24_10290 ENOG4105JRK feS assembly protein SufD HVZ24_10295 ENOG4105C9B Cysteine desulfurase HVZ24_10305 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein HVZ24_10310 ENOG4105KMX major outer membrane lipoprotein HVZ24_10315 ENOG4105CA9 Pyruvate kinase HVZ24_10320 ENOG4105RFR Protein of unknown function (DUF2767) HVZ24_10325 ENOG4108PU5 4fe-4S ferredoxin, iron-sulfur binding domain protein HVZ24_10330 ENOG4105WE2 aldehyde ferredoxin oxidoreductase HVZ24_10335 ENOG4105JVW HVZ24_10340 ENOG4108393 oxidoreductase Fe-S subunit HVZ24_10345 ENOG4108NWD Cytochrome HVZ24_10350 ENOG4108Y7C Conserved Protein HVZ24_10355 ENOG4108KTU conserved protein with FAD NAD(P)-binding domain HVZ24_10360 ENOG4105N0V mono-oxygenase ydhR HVZ24_10380 ENOG4107QI1 Mate efflux family protein HVZ24_10385 ENOG4108R6K riboflavin synthase, subunit alpha HVZ24_10390 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase HVZ24_10395 ENOG4105CZQ inner membrane transport protein YdhC HVZ24_10400 ENOG4105F52 Transcriptional regulator HVZ24_10415 ENOG4105F27 Major Facilitator HVZ24_10420 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) HVZ24_10425 ENOG4105K4H Nlp p60 protein HVZ24_10430 ENOG4105M2J Glutaredoxin HVZ24_10435 ENOG4107QRT dEAD DEAH box helicase HVZ24_10440 ENOG4105DH5 Responsible for the end-turnover of tRNA specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis (By similarity) HVZ24_10445 ENOG4108UYE Lactoylglutathione lyase HVZ24_10450 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HVZ24_10455 ENOG4108WUH Transcriptional regulator, TetR family HVZ24_10460 ENOG4105XZD Fe-S protein HVZ24_10465 ENOG4107RGM aldo keto reductase HVZ24_10470 ENOG4108Z7T Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) HVZ24_10475 ENOG4105DSW Fusaric acid resistance protein HVZ24_10480 ENOG4105Y49 secretion protein, HlyD family HVZ24_10495 ENOG4108XTF Outer Membrane Lipoprotein HVZ24_10500 ENOG4105ED7 Catalyzes the specific phosphorylation of 1,6-anhydro-N- acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling (By similarity) HVZ24_10505 ENOG410642K Lysozyme inhibitor HVZ24_10520 ENOG4107XGF functions in a salvage pathway. Uses pyridoxamine (By similarity) HVZ24_10525 ENOG4108K3A Glutathione S-transferase HVZ24_10530 ENOG4105DUX Transporter HVZ24_10535 ENOG4105CSM endonuclease III HVZ24_10545 ENOG4108UQQ Electron transport complex HVZ24_10570 ENOG4105M9B inner membrane protein ydgK HVZ24_10575 ENOG4105QZ5 OriC-binding nucleoid-associated protein HVZ24_10580 ENOG4106C6R beta-lactam resistance protein HVZ24_10585 ENOG4105D9R oxidoreductase HVZ24_10595 ENOG4105C87 Aminotransferase class I and II HVZ24_10600 ENOG4105CI1 PTS System HVZ24_10605 ENOG4107P2S Transcriptional regulator HVZ24_10610 ENOG4107ZQV short-chain dehydrogenase reductase HVZ24_10615 ENOG4105XEA Tetr family transcriptional regulator HVZ24_10620 ENOG4105CNT hydrolase family 2 HVZ24_10625 ENOG4105CT4 transporter HVZ24_10630 ENOG4108QNI outer membrane porin protein HVZ24_10635 ENOG4106J39 exported protein HVZ24_10640 ENOG4105EIP mannose-6-phosphate isomerase HVZ24_10645 ENOG4107GFK fumarate HVZ24_10650 ENOG4105C9Q fumarate hydratase class II HVZ24_10655 ENOG4105KR1 Trans-acting protein required for termination of DNA replication. Binds to DNA replication terminator sequences (terA to terF) to prevent the passage of replication forks. The termination efficiency will be affected by the affinity of this protein for the terminator sequence (By similarity) HVZ24_10660 ENOG4105JJR Histidine kinase HVZ24_10665 ENOG4107EXC regulatoR HVZ24_10670 ENOG4105RA2 Membrane HVZ24_10680 ENOG4105D5Q Arginine ornithine antiporter HVZ24_10685 ENOG4105C5D exported protein HVZ24_10690 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) HVZ24_10695 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) HVZ24_10700 ENOG4105DSF transport protein HVZ24_10715 ENOG4105CVW peptidase s1 and s6 chymotrypsin hap HVZ24_10730 ENOG4105D94 Major Facilitator Superfamily HVZ24_10735 ENOG4106NZI LysR family Transcriptional regulator HVZ24_10740 ENOG4105DAG ROK family HVZ24_10745 ENOG4105EWW Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) HVZ24_10755 ENOG4108NEM leader-binding protein dmsD HVZ24_10760 ENOG4107KGK dmso reductase anchor subunit HVZ24_10765 ENOG4105QAX Iron-sulfur HVZ24_10770 ENOG4105C3J Cysteine desulfurase HVZ24_10775 ENOG4107QY8 reductase HVZ24_10780 ENOG4105KBG Protein of unknown function (DUF1161) HVZ24_10785 ENOG4105D69 UPF0257 lipoprotein ynfC HVZ24_10790 ENOG4108MK9 spermidine N(1)-acetyltransferase HVZ24_10805 ENOG4105CXK mandelate racemase muconate lactonizing HVZ24_10810 ENOG4105CPQ Dehydrogenase HVZ24_10820 ENOG4107R08 Integrase HVZ24_10835 ENOG4106G8A Qin prophage HVZ24_10855 ENOG41087BU transcriptional repressor DicA HVZ24_10910 ENOG4105K4U addiction module toxin, RelE StbE family HVZ24_10930 ENOG4108MXB Protein of unknown function (DUF968) HVZ24_10935 ENOG4105HGD Antitermination protein HVZ24_10950 ENOG4105VEQ Cold shock protein HVZ24_10955 ENOG4105QFS Lysis protein S homolog from lambdoid prophage HVZ24_10970 ENOG4108YV9 Protein of unknown function (DUF2514) HVZ24_10975 ENOG4105VEQ Cold shock protein HVZ24_10990 ENOG4106IAW HVZ24_10995 ENOG4106H71 Overexpression increases levels of unsaturated fatty acids and suppresses both the temperature-sensitive fabA6 mutation and cold-sensitive secG null mutation HVZ24_11000 ENOG41064WM Uncharacterized protein YcgX HVZ24_11005 ENOG4106YSC HVZ24_11010 ENOG4105FKG DNA packaging protein HVZ24_11015 ENOG4105UZW Tail fiber assembly protein HVZ24_11020 ENOG4107DE1 head-to-tail joining protein HVZ24_11030 ENOG4105F7J membrane-bound serine protease HVZ24_11040 ENOG4105IM0 capsid protein HVZ24_11115 ENOG410685N tail fiber protein HVZ24_11120 ENOG4105UZW Tail fiber assembly protein HVZ24_11125 ENOG4105MN3 Resolvase HVZ24_11130 ENOG4105W3V DNA-binding, transcriptional regulator HVZ24_11145 ENOG4105DEI Mannitol dehydrogenase HVZ24_11150 ENOG41061EV selenium-binding protein YdfZ HVZ24_11155 ENOG4107XBN GntR Family Transcriptional Regulator HVZ24_11160 ENOG4105EMU Dehydrogenase HVZ24_11165 ENOG4105DGW oligopeptidase A HVZ24_11170 ENOG4108WTK competence damage-inducible protein HVZ24_11175 ENOG4108YDI single-species biofilm formation on inanimate substrate HVZ24_11180 ENOG4105FSR swimming returnes to normal when residues 206-207 are both mutated to Ala. Overexpression also leads to a reduction in flagellar abundance and a 20-fold increase in c-di- GMP levels in vivo. Required for aminoglycoside-mediated induction of biofilm formation, it also plays a lesser role in biofilm production in response to other classes of translation inhibitors. The c-di-GMP produced by this enzyme up-regulates poly-GlcNAc production as well as the biofilm synthesis protein PgaD, although c-di-GMP is probably not the main inducing principle. Cyclic-di- GMP is a second messenger which controls cell surface-associated traits in bacteria HVZ24_11190 ENOG4105E5W Transporter HVZ24_11195 ENOG4108594 Permease of the drug metabolite transporter HVZ24_11200 ENOG4106DNR multiple antibiotic resistance protein HVZ24_11205 ENOG4108XW0 May be a transcriptional activator of genes involved in the multiple antibiotic resistance (Mar) phenotype. It can also activate genes such as sodA, zwf and micF HVZ24_11210 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes HVZ24_11230 ENOG4105EGI Transcriptional regulator HVZ24_11235 ENOG4105C26 Dehydrogenase HVZ24_11240 ENOG4105CSV Glutaminase HVZ24_11245 ENOG4105M0C cytoplasmic protein HVZ24_11260 ENOG4105FFC UPF0187 protein HVZ24_11265 ENOG4107R6G Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate (By similarity) HVZ24_11270 ENOG4105K34 Involved in the degradation of phospho-AI-2, thereby terminating induction of the lsr operon and closing the AI-2 signaling cycle. Catalyzes the cleavage of phosphorylated 4,5- dihydroxy-2,3-pentanedione (P-DPD) to 2-phosphoglycolic acid (PG) and another three-carbon compound HVZ24_11275 ENOG41061GT Aldolase HVZ24_11280 ENOG4105D4B ABC, transporter HVZ24_11290 ENOG41071MT Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane HVZ24_11295 ENOG4105C2J ABC transporter HVZ24_11300 ENOG4105DKT Transcriptional regulator HVZ24_11305 ENOG4108EMV Catalyzes the phosphorylation of autoinducer 2 (AI-2) to phospho-AI-2, which subsequently inactivates the transcriptional regulator LsrR and leads to the transcription of the lsr operon. Phosphorylates the ring-open form of 4,5-dihydroxy-2,3- pentanedione (DPD), which is the precursor to all AI-2 signaling molecules, at the C5 position (By similarity) HVZ24_11320 ENOG41061P8 Persistence to inhibition of murein or DNA biosynthesis regulatory protein HVZ24_11325 ENOG4105CAF HipA N-terminal domain protein HVZ24_11350 ENOG4108IMY Transcriptional regulator HVZ24_11365 ENOG4107R2I The heterodimer acts as both an ATP-dependent DNA helicase and an ATP-dependent, dual-direction single-stranded exonuclease. Recognizes the chi site generating a DNA molecule suitable for the initiation of homologous recombination. The AddA nuclease domain is required for chi fragment generation HVZ24_11375 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving HVZ24_11425 ENOG4105DZR Type I site-specific deoxyribonuclease HVZ24_11430 ENOG4106RHG Yeca family HVZ24_11460 ENOG4108WDE Fimbrial protein HVZ24_11465 ENOG4106318 fimbrial-like protein YdeR HVZ24_11470 ENOG4106PIH fimbrial-like protein ydeQ HVZ24_11475 ENOG4107QKC Oxidoreductase alpha (molybdopterin) subunit HVZ24_11485 ENOG4105Z68 AraC Family Transcriptional Regulator HVZ24_11490 ENOG4105ENH Sulfatase HVZ24_11495 ENOG4105C4X radical SAM domain protein HVZ24_11505 ENOG4105CQ0 ABC transporter HVZ24_11510 ENOG4105PE1 Receptor HVZ24_11515 ENOG4107RAN Peptidase, M16 HVZ24_11520 ENOG4105CVK Glutamate decarboxylase HVZ24_11525 ENOG4105E5D amino acid HVZ24_11530 ENOG4105F32 YngK protein HVZ24_11540 ENOG4105BZU Histidine kinase HVZ24_11545 ENOG4105BZU Histidine kinase HVZ24_11550 ENOG4108UQS dipeptidase HVZ24_11560 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HVZ24_11565 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HVZ24_11570 ENOG4105C3U ABC transporter HVZ24_11575 ENOG4107H6U ABC transporter HVZ24_11580 ENOG4108Z9K Osmotically inducible protein HVZ24_11585 ENOG4105TPS biofilm-dependent modulation protein HVZ24_11590 ENOG4107AV5 Although this protein associates with the 30S subunit of the ribosome it is not considered to be a bona fide ribosomal protein HVZ24_11595 ENOG4107R1I NAD-dependent malic enzyme HVZ24_11600 ENOG4105DQ4 alcohol dehydrogenase HVZ24_11605 ENOG41084S7 Plasmid maintenance system antidote protein HVZ24_11610 ENOG4108MG3 formate dehydrogenase HVZ24_11615 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein HVZ24_11625 ENOG4105RPH Inner membrane protein YddG HVZ24_11640 ENOG4107QND Nitrite extrusion protein HVZ24_11645 ENOG4105CRU nitrate reductase, alpha subunit HVZ24_11650 ENOG4108IUE nitrate reductase beta subunit HVZ24_11655 ENOG4108NZN Respiratory nitrate reductase 2 delta chain HVZ24_11660 ENOG4105D0D Nitrate reductase 2, gamma subunit HVZ24_11665 ENOG4105JAB phenazine biosynthesis protein, phzf family HVZ24_11670 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase HVZ24_11675 ENOG4108MEJ flavin reductase domain protein HVZ24_11680 ENOG4105KZK Tautomerase pptA HVZ24_11715 ENOG4108N27 Glutathione S-transferase HVZ24_11720 ENOG4105C85 amino acid HVZ24_11725 ENOG4108NS2 receptor HVZ24_11730 ENOG4105CHB tonB-dependent Receptor HVZ24_11735 ENOG4108WYP Transcriptional regulator HVZ24_11740 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein HVZ24_11745 ENOG4108Z7F N-acetyltransferase HVZ24_11750 ENOG4108T9Y Inner membrane protein ydcZ HVZ24_11755 ENOG4105R71 cytoplasmic protein HVZ24_11760 ENOG410654E Membrane HVZ24_11770 ENOG4105C26 Dehydrogenase HVZ24_11775 ENOG4105NRK Binding-protein-dependent transport systems, inner membrane component HVZ24_11780 ENOG4105D81 ABC transporter, permease HVZ24_11785 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HVZ24_11790 ENOG4107TYH extracellular solute-binding protein family 1 HVZ24_11795 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HVZ24_11800 ENOG4105PF0 Antitoxin component of a toxin-antitoxin (TA) module. Functions as an mRNA interferase antitoxin HVZ24_11810 ENOG4105RR0 Protein of unknown function (DUF2554) HVZ24_11815 ENOG4105CFP Peptidase U32 HVZ24_11820 ENOG4108JCI Transcriptional regulator HVZ24_11825 ENOG4105DKK Benzoate HVZ24_11830 ENOG4105D7V transposase HVZ24_11840 ENOG4108KKZ (LipO)protein HVZ24_11845 ENOG41088CC tellurite resistance protein tehB HVZ24_11850 ENOG4108NKP c4-dicarboxylate transporter malic acid transport protein HVZ24_11855 ENOG4107WE3 acetyltransferase YdcK HVZ24_11860 ENOG4108Z9I -acetyltransferase HVZ24_11865 ENOG4105Z2P Protein of unknown function (DUF465) HVZ24_11870 ENOG4105DJ9 glucan biosynthesis protein HVZ24_11875 ENOG4105E32 cytoplasmic protein HVZ24_11880 ENOG4105DDW LysR family Transcriptional regulator HVZ24_11885 ENOG4105C8Q Methyl-accepting chemotaxis HVZ24_11890 ENOG4107NK6 Hok/gef family HVZ24_11895 ENOG4105UPP uncharacterized protein ydcA HVZ24_11900 ENOG4105CPW cytochrome b561 HVZ24_11910 ENOG4105C26 Dehydrogenase HVZ24_11915 ENOG4107DB1 DUF218 domain HVZ24_11920 ENOG4105CQ7 ATP-dependent helicase HVZ24_11930 ENOG41077RS Phosphatase HVZ24_11935 ENOG4105E8V Alpha Beta Hydrolase Fold protein HVZ24_11940 ENOG4108HPI phosphatidate Cytidylyltransferase HVZ24_11945 ENOG4108UMZ Cdp-alcohol phosphatidyltransferase HVZ24_11955 ENOG4107S5I aldo keto reductase HVZ24_11960 ENOG4107EF2 surface-exposed virulence protein HVZ24_11970 ENOG4108Z0R Transferase HVZ24_11975 ENOG4105V9J phenylacetic acid degradation operon negative regulatory protein HVZ24_11980 ENOG4105DZS Phenylacetate-CoA ligase HVZ24_11985 ENOG4105CHU acetyl-coa acetyltransferase HVZ24_11990 ENOG4108ZJI phenylacetic acid degradation protein HVZ24_11995 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase HVZ24_12000 ENOG4108UKI Enoyl-CoA hydratase HVZ24_12005 ENOG4105E39 Enoyl-CoA hydratase HVZ24_12010 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) HVZ24_12015 ENOG4108ZA2 phenylacetate-CoA oxygenase PaaJ subunit HVZ24_12020 ENOG4105D9S phenylacetate-CoA oxygenase PaaI subunit HVZ24_12025 ENOG4105N76 Phenylacetate-CoA oxygenase, subunit HVZ24_12030 ENOG4105CRS phenylacetate-CoA oxygenase PaaG subunit HVZ24_12035 ENOG4105DXM phenylacetic acid degradation protein HVZ24_12040 ENOG4105F11 amine oxidase HVZ24_12045 ENOG4105C26 Dehydrogenase HVZ24_12050 ENOG4108WFR AraC Family Transcriptional Regulator HVZ24_12055 ENOG4105WXT Conserved Protein HVZ24_12060 ENOG410689M (LipO)protein HVZ24_12065 ENOG4107H52 Dicarboxylate transport HVZ24_12070 ENOG4105C5I Dehydrogenase HVZ24_12075 ENOG41090X5 Heat shock protein hslJ HVZ24_12080 ENOG4105IKK cytoplasmic protein HVZ24_12085 ENOG4105D95 Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity) HVZ24_12090 ENOG4105FCK Membrane HVZ24_12095 ENOG4108RW8 Universal stress protein F HVZ24_12105 ENOG4105W3V DNA-binding, transcriptional regulator HVZ24_12110 ENOG4105MN3 Resolvase HVZ24_12115 ENOG4105UZW Tail fiber assembly protein HVZ24_12135 ENOG4108ES9 ParB domain protein nuclease HVZ24_12140 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) HVZ24_12175 ENOG4105RWQ Protein of unknown function (DUF1364) HVZ24_12195 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) HVZ24_12200 ENOG4105EKD Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism (By similarity) HVZ24_12220 ENOG4105JBR DNA replication protein HVZ24_12225 ENOG4105ZTP Protein of unknown function (DUF1376) HVZ24_12235 ENOG4105W7J DNA binding HVZ24_12240 ENOG410649Z repressor HVZ24_12260 ENOG4107C82 Rac prophage HVZ24_12270 ENOG41076J9 exonuclease VIII HVZ24_12275 ENOG4108PNI recT protein HVZ24_12280 ENOG4106YAH restriction alleviation and modification enhancement HVZ24_12285 ENOG41070YT Rac prophage HVZ24_12290 ENOG4107160 Rac prophage HVZ24_12295 ENOG4107R08 Integrase HVZ24_12300 ENOG4105CB3 Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity) HVZ24_12305 ENOG4105C1J atp-dependent rna helicase HVZ24_12315 ENOG4105BZU Histidine kinase HVZ24_12320 ENOG4108DG9 Smr protein MutS2 HVZ24_12325 ENOG4106KR7 LysR family Transcriptional regulator HVZ24_12330 ENOG4105CH2 amidohydrolase HVZ24_12335 ENOG4107RT5 aminobenzoyl-glutamate utilization protein B HVZ24_12340 ENOG4105CFC Transporter HVZ24_12345 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) HVZ24_12350 ENOG4105DS0 Transcriptional regulator, Crp Fnr family HVZ24_12355 ENOG4105Q9Y Universal stress protein HVZ24_12360 ENOG4105S5I Membrane HVZ24_12365 ENOG4105D64 Mechanosensitive ion channel HVZ24_12370 ENOG4107QSI ABC, transporter HVZ24_12375 ENOG4105EQ2 LysR family Transcriptional regulator HVZ24_12380 ENOG4105ENX hydrolase HVZ24_12395 ENOG4105KXI murein peptide amidase A HVZ24_12400 ENOG4107S8C mandelate racemase muconate lactonizing HVZ24_12405 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) HVZ24_12410 ENOG4108JU8 Transcriptional regulator HVZ24_12420 ENOG4105CM6 amino acid regulated cytosolic protein HVZ24_12425 ENOG4105FKQ transcriptional regulator HVZ24_12430 ENOG4107EFV Outer membrane protein G HVZ24_12435 ENOG4108IJ9 (ABC) transporter HVZ24_12440 ENOG4107URF beta-phospho-glucomutase HVZ24_12445 ENOG4105C71 hydrolase family 65, central catalytic HVZ24_12450 ENOG4105CK5 oxidoreductase HVZ24_12455 ENOG4107TYA transient receptor potential locus HVZ24_12460 ENOG4107RRD Dehydrogenase HVZ24_12465 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component HVZ24_12470 ENOG4105HS6 binding-protein-dependent transport systems inner membrane Component HVZ24_12475 ENOG4105WEM extracellular solute-binding protein HVZ24_12480 ENOG4107QW3 Sucrose phosphorylase HVZ24_12485 ENOG4105K8Z Phage shock protein HVZ24_12490 ENOG4105NNG Peripheral inner membrane phage-shock protein HVZ24_12495 ENOG4105FM1 phage shock protein C HVZ24_12500 ENOG4105YYT phage shock protein B HVZ24_12505 ENOG41087YS Phage shock protein A HVZ24_12510 ENOG4105E51 psp operon transcriptional activator HVZ24_12515 ENOG4108JPW Aminotransferase HVZ24_12520 ENOG4105CJP fad dependent oxidoreductase HVZ24_12525 ENOG4105C26 Dehydrogenase HVZ24_12530 ENOG4107VRI Transcriptional regulator HVZ24_12535 ENOG4108Z86 Glutamine amidotransferase HVZ24_12540 ENOG4105CFQ glutamine synthetase HVZ24_12550 ENOG4105CUB amino acid HVZ24_12555 ENOG4105N0E Protein of unknown function (DUF2543) HVZ24_12560 ENOG4108HIY periplasmic HVZ24_12565 ENOG4108I5W peptide transport system, permease protein HVZ24_12570 ENOG4108EU3 peptide transport system, permease HVZ24_12575 ENOG4108JQ3 Peptide ABC transporter ATP-binding protein HVZ24_12580 ENOG4108JQ2 peptide transport system atp-binding protein HVZ24_12585 ENOG4105WDY DNA (cytosine-5-)-methyltransferase HVZ24_12590 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH HVZ24_12595 ENOG4105Q4T oxidoreductase HVZ24_12610 ENOG4105BZU Histidine kinase HVZ24_12615 ENOG410643D UPF0509 protein HVZ24_12620 ENOG4105N2W Transcriptional regulator HVZ24_12630 ENOG4108ZJT translation initiation factor, Sui1 HVZ24_12635 ENOG4106EG9 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) HVZ24_12640 ENOG4105CFV Tetratricopeptide repeat protein HVZ24_12645 ENOG4105Q4A inner membrane protein yciS HVZ24_12650 ENOG4105EYK Phosphatidylglycerophosphatase B HVZ24_12660 ENOG4107QM5 aconitate hydratase HVZ24_12680 ENOG4107R11 Transcriptional regulator HVZ24_12685 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) HVZ24_12690 ENOG4105RKX Protein of unknown function (DUF2498) HVZ24_12695 ENOG4105ERU peptidase HVZ24_12700 ENOG4105UBK short-chain dehydrogenase reductase HVZ24_12705 ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase HVZ24_12710 ENOG4105FE9 pseudouridine synthase HVZ24_12715 ENOG4105EG3 transmembrane signal peptide protein HVZ24_12720 ENOG4107RTD sua5 ycio yrdc ywlc family protein HVZ24_12725 ENOG4105DB7 PHP domain protein HVZ24_12735 ENOG4105CRQ synthase (Component I) HVZ24_12740 ENOG4108EFP Anthranilate synthase component II HVZ24_12745 ENOG4105DK0 Indole-3-glycerol phosphate synthase HVZ24_12765 ENOG4108Z9Z response to DNA damage stimulus HVZ24_12770 ENOG4108N8X transition metal ion binding HVZ24_12775 ENOG4105EIF outer membrane protein W HVZ24_12785 ENOG4108S3I UPF0259 membrane protein HVZ24_12795 ENOG4105NAU thioesterase Superfamily protein HVZ24_12800 ENOG410822N TonB family HVZ24_12805 ENOG4105K9H YciI-like protein HVZ24_12810 ENOG4107SVH Potassium channel protein HVZ24_12830 ENOG4108JQ7 (ABC) transporter HVZ24_12835 ENOG4105C3U ABC transporter HVZ24_12840 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HVZ24_12845 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HVZ24_12850 ENOG4108J59 Extracellular solute-binding protein, family 5 HVZ24_12860 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein HVZ24_12865 ENOG4105C0A alcohol dehydrogenase HVZ24_12875 ENOG4107104 thymidine kinase HVZ24_12880 ENOG4108SAU DNA-binding protein H-ns HVZ24_12885 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase HVZ24_12890 ENOG4105I93 response regulator HVZ24_12895 ENOG4105D78 K07001 NTE family protein HVZ24_12900 ENOG4105K5B UPF0225 protein HVZ24_12905 ENOG4105CIY formyltetrahydrofolate deformylase HVZ24_12940 ENOG41076YT nitrate reductase, gamma subunit HVZ24_12945 ENOG4105R3A Nitrate reductase HVZ24_12950 ENOG4108IUE nitrate reductase beta subunit HVZ24_12955 ENOG4105CRU nitrate reductase, alpha subunit HVZ24_12960 ENOG4105DQQ Major facilitator superfamily MFS_1 HVZ24_12965 ENOG4105BZU Histidine kinase HVZ24_12970 ENOG4105WH1 Two component transcriptional regulator luxr family HVZ24_12975 ENOG4105ID0 Putative invasin HVZ24_12980 ENOG41090EX DsrE family HVZ24_12985 ENOG4108NH8 Cation transport protein HVZ24_12990 ENOG4105WS7 Cation transport regulator HVZ24_12995 ENOG4105EWV Sodium calcium exchanger membrane region HVZ24_13020 ENOG41063JG Transcriptional regulator HVZ24_13025 ENOG4108YY7 Invasion gene expression up-regulator SirB HVZ24_13030 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) HVZ24_13040 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) HVZ24_13050 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) HVZ24_13055 ENOG4105C5T Phosphoribosyl pyrophosphate synthase HVZ24_13060 ENOG4105CHH sulfate transporter HVZ24_13065 ENOG4105MGX transcription activated by CRP (cyclic AMP receptor protein), a global transcription factor involved in regulation of metabolism in enteric bacteria HVZ24_13075 ENOG4105C3G gtp-binding protein HVZ24_13080 ENOG4105I1J Autotransporter HVZ24_13085 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family HVZ24_13090 ENOG4105CMT Dihydroxyacetone kinase HVZ24_13095 ENOG4108UTZ Dihydroxyacetone kinase HVZ24_13100 ENOG4105VDH Dihydroxyacetone kinase HVZ24_13115 ENOG4105Y3U Transglycosylase-associated protein HVZ24_13120 ENOG4108T7K Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Increasing levels of c-di-GMP lead to decreased motility (By similarity) HVZ24_13125 ENOG4106S48 Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and or cell division HVZ24_13130 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A HVZ24_13140 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) HVZ24_13150 ENOG4105ED1 spovr family HVZ24_13165 ENOG410635M Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein (By similarity) HVZ24_13170 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) HVZ24_13175 ENOG4105KT5 UmuD protein HVZ24_13180 ENOG4106PXS Toxin, which has some hemolytic activity towards mammalian cells. Acts by forming a pore-like structure upon contact with mammalian cells HVZ24_13190 ENOG4105FBJ fumarylacetoacetate (faa) hydrolase HVZ24_13200 ENOG41066UD Inhibits activity of g-type lysozyme, which confers increased lysozyme tolerance to the bacterium HVZ24_13205 ENOG4105S66 prophage protein HVZ24_13210 ENOG4105K7U Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) HVZ24_13215 ENOG4107QMS site-determining protein HVZ24_13250 ENOG410658X HVZ24_13265 ENOG4105BZU Histidine kinase HVZ24_13270 ENOG410738I uncharacterized protein ymgC HVZ24_13280 ENOG41077SS Probably a connector protein for RcsB C regulation of biofilm formation, providing additional signal input into the two- component signaling pathway. May serve to stimulate biofilm maturation, probably via the Rcs phosphorelay. Mild overexpression at 16 degrees Celsius increases the production of colanic acid, an exopolysaccharide and matrix component, and reduces adhesive curli fimbriae expression. Both of these effects require RcsB HVZ24_13285 ENOG4105WKE Probably a connector protein for RcsB C regulation of biofilm formation, providing additional signal input into the two- component signaling pathway. Partially antagonizes the activities of YmgA and AriR, proteins that, via the Rcs phosphorelay, promote the synthesis of colanic acid, an exopolysaccharide and matrix component HVZ24_13290 ENOG4105BZU Histidine kinase HVZ24_13295 ENOG4108XDN Transcriptional regulator HVZ24_13300 ENOG41064WM Uncharacterized protein YcgX HVZ24_13315 ENOG41066T8 Inhibits RpoS proteolysis by regulating RssB activity, thereby increasing the stability of the sigma stress factor RpoS during magnesium starvation (By similarity) HVZ24_13320 ENOG4108HMX isocitrate dehydrogenase (NADP) HVZ24_13325 ENOG4108R99 pseudouridine synthase HVZ24_13345 ENOG4107QTF adenylosuccinate lyase HVZ24_13350 ENOG4105XJC Two component transcriptional regulator (Winged helix family HVZ24_13355 ENOG4105IFJ Histidine kinase HVZ24_13360 ENOG4105EZE Cupin 4 family protein HVZ24_13365 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) HVZ24_13370 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HVZ24_13380 ENOG4105D38 putrescine abc transporter HVZ24_13385 ENOG4107RUE extracellular solute-binding protein family 1 HVZ24_13400 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) HVZ24_13410 ENOG4105D60 lipoprotein releasing system transmembrane protein HVZ24_13415 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) HVZ24_13420 ENOG4105D60 lipoprotein releasing system transmembrane protein HVZ24_13425 ENOG4105IQC Inner membrane protein YcfT HVZ24_13430 ENOG4108JA2 transcriptioN-repair coupling factor HVZ24_13435 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein HVZ24_13440 ENOG4105RC8 Reduces the permeability of the outer membrane to copper. Seems to be involved in the regulation of biofilm formation. May decrease biofilm formation by repressing cell-cell interaction and cell surface interaction HVZ24_13445 ENOG4108IND Tetr family transcriptional regulator HVZ24_13450 ENOG4107MBR 17 kDa surface antigen HVZ24_13455 ENOG4105CEP NADH dehydrogenase HVZ24_13465 ENOG4107QPA Cleaves GlcNAc linked beta-1,4 to MurNAc tripeptides (By similarity) HVZ24_13470 ENOG4108RUM thiamine kinase HVZ24_13475 ENOG4108WEF Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b) (By similarity) HVZ24_13480 ENOG41090DQ Lipoprotein HVZ24_13485 ENOG4105K59 histidine triad (HIT) protein HVZ24_13490 ENOG4105CNM Receptor HVZ24_13495 ENOG4105CI1 PTS System HVZ24_13500 ENOG4105F8V Hydrolase, tatD family HVZ24_13505 ENOG4107QRG dna polymerase iii HVZ24_13515 ENOG4105HHA aminodeoxychorismate lyase HVZ24_13520 ENOG4105YAZ 4-amino-4-deoxychorismate lyase HVZ24_13525 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) HVZ24_13530 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) HVZ24_13535 ENOG4105CHR reductase HVZ24_13540 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase HVZ24_13560 ENOG4105FCQ metal-binding, possibly nucleic acid-binding protein HVZ24_13565 ENOG4108UHJ MAF-like protein HVZ24_13570 ENOG4105EI2 Pseudouridine synthase HVZ24_13575 ENOG4107QQB Ribonuclease E HVZ24_13580 ENOG4105DTJ flagellar hook-associated protein HVZ24_13585 ENOG4105E1Q flagellar hook-associated protein HVZ24_13590 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj HVZ24_13605 ENOG4105CGA flagellar basal-body rod protein FlgG HVZ24_13610 ENOG4108KPB Flagellar basal-body rod protein FlgF HVZ24_13615 ENOG4105BZE flagellar hook protein, FlgE HVZ24_13620 ENOG4105W00 Flagellar hook capping protein HVZ24_13625 ENOG4108ZC9 flagellar basal-body rod protein flgc HVZ24_13630 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) HVZ24_13635 ENOG4105CKS Flagella basal body P-ring formation protein flgA HVZ24_13640 ENOG4105M9M anti-sigma28 factor FlgM HVZ24_13645 ENOG4105QVD Flagella synthesis protein FlgN HVZ24_13650 ENOG4105CJR Integral membrane protein (MviN HVZ24_13655 ENOG4105EP9 oxidoreductase HVZ24_13660 ENOG4108YXG UPF0502 protein HVZ24_13665 ENOG4105D9U N-acetyltransferase HVZ24_13675 ENOG4105E9S glutaredoxin 2 HVZ24_13680 ENOG4105F3T (LipO)protein HVZ24_13685 ENOG4105EKE dihydroorotase HVZ24_13690 ENOG4105MEA DNA damage-inducible protein i HVZ24_13695 ENOG4105PVA Biofilm formation regulatory protein BssS HVZ24_13700 ENOG4105F76 Sarcosine oxidase HVZ24_13705 ENOG4106974 biofilm formation HVZ24_13710 ENOG4105DS1 cytochrome b561 HVZ24_13715 ENOG4108YYC ycei family HVZ24_13720 ENOG4105C72 UPF0176 protein HVZ24_13725 ENOG4105D1S lipid A biosynthesis HVZ24_13735 ENOG4108W47 Acidic protein msyB HVZ24_13740 ENOG4105NAC (LipO)protein HVZ24_13745 ENOG4105C3A Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs) (By similarity) HVZ24_13750 ENOG4105DJ9 glucan biosynthesis protein HVZ24_13755 ENOG4105EIK Necessary for the succinyl substitution of periplasmic glucans. Could catalyze the transfer of succinyl residues from the cytoplasmic side of the membrane to the nascent glucan backbones on the periplasmic side of the membrane (By similarity) HVZ24_13760 ENOG4107RZC phospholipase d HVZ24_13765 ENOG4108UVJ appr-1-p processing domain protein HVZ24_13775 ENOG4105RK8 Plays a role in the extracellular assembly of CsgA into thin aggregative fimbriae (Tafi) fibers. Assembly may also require CsgE. Tafi are thought to be assembled via an extracellular nucleation-precipitation (ENP) pathway, and possibly also via an intracellular non-CsgC-dependent pathway (By similarity) HVZ24_13780 ENOG4105G76 Curli are coiled surface structures that assemble preferentially at growth temperatures below 37 degrees Celsius. Curli can bind to fibronectin HVZ24_13785 ENOG4108U0V Curli are coiled surface structures that assemble preferentially at growth temperatures below 37 degrees Celsius. Curli can bind to fibronectin. The minor subunit is the nucleation component of curlin monomers HVZ24_13790 ENOG41086KC Transcriptional regulator HVZ24_13795 ENOG4108XDW curli assembly protein CsgE HVZ24_13800 ENOG4108WYR Curli production assembly transport component, CsgF HVZ24_13805 ENOG4105P8Q Curli production assembly transport component CsgG HVZ24_13810 ENOG4108UQ5 membrane protein YcdZ HVZ24_13815 ENOG4107XHZ cytoplasmic chaperone TorD family protein HVZ24_13820 ENOG4107SSZ Phosphatase HVZ24_13825 ENOG4105JPG D-isomer specific 2-hydroxyacid dehydrogenase HVZ24_13850 ENOG4108T85 Membrane HVZ24_13865 ENOG4105BZU Histidine kinase HVZ24_13870 ENOG4108TUY outer membrane protein PgaA HVZ24_13875 ENOG4107BJW polysaccharide deacetylase HVZ24_13880 ENOG4105CND Glycosyl transferase, family 2 HVZ24_13890 ENOG4105D5M phosphate starvation-inducible protein HVZ24_13895 ENOG4105DBE peroxidase HVZ24_13900 ENOG410650H (LipO)protein HVZ24_13910 ENOG4105CK7 Sodium proline symporter HVZ24_13920 ENOG4105C26 Dehydrogenase HVZ24_13925 ENOG4108R86 Transcriptional regulator HVZ24_13930 ENOG4105EQP Catalyzes the pyrimidine ring opening between N-3 and C- 4 by an unusual flavin hydroperoxide-catalyzed mechanism to yield ureidoacrylate peracid. It cleaves pyrmidine rings directly by adding oxygen atoms, making a toxic ureidoacrylate peracid product which can be spontaneously reduced to ureidoacrylate (By similarity) HVZ24_13935 ENOG4106XMA In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2 (By similarity) HVZ24_13945 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) HVZ24_13950 ENOG4108RDT NADH dehydrogenase NAD(P)H nitroreductase) HVZ24_13955 ENOG4107YAQ Catalyzes the reduction of FMN to FMNH2 which is used to reduce pyrimidine by RutA via the Rut pathway (By similarity) HVZ24_13960 ENOG4105C2W permease HVZ24_13965 ENOG4105XF5 Escherichia coli IMT2125 genomic chromosome, IMT2125 HVZ24_13975 ENOG4105XH3 HVZ24_13980 ENOG4105D6F Phosphatase HVZ24_14000 ENOG4108SBI Involved in the biogenesis of TorA. Acts on TorA before the insertion of the molybdenum cofactor and, as a result, probably favors a conformation of the apoenzyme that is competent for acquiring the cofactor (By similarity) HVZ24_14005 ENOG4107QY8 reductase HVZ24_14010 ENOG4105CUW cytochrome C-TYPE protein HVZ24_14015 ENOG4106WF9 DNA-binding transcriptional regulator TorR HVZ24_14020 ENOG4108SV3 Tmao reductase system periplasmic protein tort HVZ24_14025 ENOG4105BZU Histidine kinase HVZ24_14030 ENOG4105HEE Binding Domain protein HVZ24_14035 ENOG4106H71 Overexpression increases levels of unsaturated fatty acids and suppresses both the temperature-sensitive fabA6 mutation and cold-sensitive secG null mutation HVZ24_14050 ENOG4105VEQ Cold shock protein HVZ24_14055 ENOG41060EU Cold shock-like protein HVZ24_14070 ENOG4108Y9B (LipO)protein HVZ24_14075 ENOG4108W78 Pfam:DUF1017 HVZ24_14080 ENOG4105E3R (LipO)protein HVZ24_14085 ENOG4105DAY polysaccharide export protein HVZ24_14090 ENOG4107ZF2 Phosphatase HVZ24_14095 ENOG4105D75 Capsular exopolysaccharide family HVZ24_14100 ENOG4105D6F Phosphatase HVZ24_14110 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii HVZ24_14115 ENOG4105C4M (Ubiquinol oxidase) subunit I HVZ24_14120 ENOG4105MVP hydrogenase-1 operon protein HyaF HVZ24_14125 ENOG4108VXY Hydrogenase-1 operon protein HyaE HVZ24_14130 ENOG4108USZ hydrogenase HVZ24_14135 ENOG4105X7T Ni Fe-hydrogenase, b-type cytochrome subunit HVZ24_14140 ENOG4105DPX Hydrogenase, large subunit HVZ24_14145 ENOG4105E3S small subunit HVZ24_14155 ENOG4108MN8 Membrane HVZ24_14160 ENOG4108Z0T Part of a sulfur-relay system (By similarity) HVZ24_14165 ENOG4105VSY K01512 acylphosphatase EC 3.6.1.7 HVZ24_14180 ENOG4105K4P CoA-binding domain protein HVZ24_14195 ENOG41088T4 Helicase IV HVZ24_14200 ENOG410901E Membrane HVZ24_14205 ENOG4105EM2 membrane HVZ24_14210 ENOG4108RZ1 DNA transformation protein HVZ24_14220 ENOG4105UYK outer membrane protein a HVZ24_14230 ENOG4105DAN ATP-dependent protease HVZ24_14240 ENOG4105WFT During stationary phase, converts 70S ribosomes to an inactive dimeric form (100S ribosomes) (By similarity) HVZ24_14245 ENOG4108Q2G (LipO)protein HVZ24_14250 ENOG4105DY2 Paraquat-inducible protein b HVZ24_14255 ENOG4105F1S paraquat-inducible protein a HVZ24_14260 ENOG4105C5H ABC transporter HVZ24_14270 ENOG4105QVC MOSC domain-containing protein HVZ24_14275 ENOG4108T7E Contributes to the efficiency of the cell division process by stabilizing the polymeric form of the cell division protein FtsZ. Acts by promoting interactions between FtsZ protofilaments and suppressing the GTPase activity of FtsZ (By similarity) HVZ24_14285 ENOG4106PH7 chaperone HVZ24_14290 ENOG4105MX3 Fimbrial HVZ24_14295 ENOG4105Q7J Fimbrial HVZ24_14300 ENOG4108MDY Fimbrial HVZ24_14305 ENOG4105CW0 outer membrane usher protein HVZ24_14310 ENOG4106JJN Part of the elfADCG-ycbUVF fimbrial operon, which promotes adhesion of bacteria to different abiotic surfaces. Could be required for the biogenesis of the ElfA fimbriae HVZ24_14315 ENOG41071VI Part of the elfADCG-ycbUVF fimbrial operon, which promotes adhesion of bacteria to different abiotic surfaces. ElfA is the major fimbrial subunit produced by this operon HVZ24_14320 ENOG4108UZX fmn reductase HVZ24_14325 ENOG4105GVF (ABC) transporter HVZ24_14335 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component HVZ24_14340 ENOG4105E2Y ABC, transporter HVZ24_14345 ENOG4105CD8 aminopeptidase N HVZ24_14350 ENOG4107RH7 Nicotinate phosphoribosyltransferase HVZ24_14360 ENOG4105FCK Membrane HVZ24_14365 ENOG4105CGF Aromatic amino acid aminotransferase HVZ24_14370 ENOG4105C5X domain protein HVZ24_14375 ENOG4105EAQ (twin-arginine translocation) pathway signal HVZ24_14380 ENOG4105DIT ErfK YbiS YcfS YnhG family protein HVZ24_14385 ENOG4105DUC Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division (By similarity) HVZ24_14390 ENOG4105DAH Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF (By similarity) HVZ24_14400 ENOG4106371 Methyltransferase HVZ24_14405 ENOG4107S90 membrAne HVZ24_14410 ENOG4107VR7 transferase activity, transferring phosphorus-containing groups HVZ24_14425 ENOG4105T0Z Conserved Protein HVZ24_14430 ENOG4105CHD Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity) HVZ24_14435 ENOG4105BZ1 (ABC) transporter HVZ24_14440 ENOG4108EQH DNA internalization-related competence protein ComEC Rec2 HVZ24_14450 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) HVZ24_14460 ENOG4108K0D peptidase, M48 HVZ24_14470 ENOG4107QM1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) HVZ24_14475 ENOG4107VMU Membrane HVZ24_14480 ENOG4105DDY UPF0142 protein ycaO HVZ24_14485 ENOG4105TMB Formate nitrite transporter HVZ24_14490 ENOG4105C6N Formate acetyltransferase HVZ24_14495 ENOG4105F1A Pyruvate formate-lyase HVZ24_14500 ENOG4108X0B nad(p)h dehydrogenase (quinone) HVZ24_14505 ENOG410642W LysR family Transcriptional regulator HVZ24_14510 ENOG4105E5D amino acid HVZ24_14520 ENOG4105CHJ isochorismatase hydrolase HVZ24_14525 ENOG4107KGK dmso reductase anchor subunit HVZ24_14530 ENOG4105QAX Iron-sulfur HVZ24_14535 ENOG4107QY8 reductase HVZ24_14545 ENOG4105D1H recombination factor protein RarA HVZ24_14555 ENOG4105CNU cell division protein FtsK HVZ24_14565 ENOG4105C3M thioredoxin reductase HVZ24_14570 ENOG4108JJ9 ABC, transporter HVZ24_14575 ENOG4108JJ8 (ABC) transporter HVZ24_14585 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) HVZ24_14595 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit HVZ24_14605 ENOG4105VEQ Cold shock protein HVZ24_14610 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) HVZ24_14615 ENOG4105DJY efflux transporter, rnd family, mfp subunit HVZ24_14620 ENOG4108MJ5 VirK protein HVZ24_14625 ENOG4105CPB ATP-dependent endonuclease of the OLD family HVZ24_14630 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) HVZ24_14635 ENOG4105DWU Membrane HVZ24_14645 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) HVZ24_14650 ENOG4105C7K acetolactate synthase HVZ24_14655 ENOG4105C5W Aldolase HVZ24_14660 ENOG4105CGD Nad-dependent epimerase dehydratase HVZ24_14665 ENOG4107VBM 3-beta hydroxysteroid dehydrogenase isomerase HVZ24_14670 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase HVZ24_14680 ENOG41064MM (LipO)protein HVZ24_14685 ENOG4105E5Z arginine transporter ATP-binding subunit HVZ24_14690 ENOG4106PMH Extracellular solute-binding protein family 3 HVZ24_14695 ENOG4105GBT ABC transporter HVZ24_14700 ENOG4105DMR ABC, transporter HVZ24_14705 ENOG4106TNF Periplasmic binding protein HVZ24_14710 ENOG4107SFS Catalyzes the formation of 5-methyl-uridine at position 747 (m5U747) in 23S rRNA (By similarity) HVZ24_14715 ENOG4105RBQ inner membrane protein ybjO HVZ24_14720 ENOG4105D38 putrescine abc transporter HVZ24_14725 ENOG4105F38 ABC transporter, permease HVZ24_14730 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HVZ24_14735 ENOG4107RUE extracellular solute-binding protein family 1 HVZ24_14740 ENOG4108RMJ sensory transduction regulator HVZ24_14750 ENOG4108DBC nitroreductase HVZ24_14755 ENOG4105X20 member of the soxRS regulon which mediates in part the increased levels of superoxide in response to oxidative stress HVZ24_14760 ENOG41090BQ Glutaredoxin HVZ24_14765 ENOG4105GWF inner membrane protein YbjM HVZ24_14775 ENOG4105ZTC transcriptional activator, Ogr delta HVZ24_14910 ENOG4105ED4 portal protein HVZ24_14930 ENOG4105VZ1 Replication Protein HVZ24_14935 ENOG4105DFE Dna adenine methylase HVZ24_14940 ENOG4105KSC Transcriptional regulator, TraR DksA family HVZ24_14965 ENOG4105MEH HVZ24_14985 ENOG4108IYT Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HVZ24_14990 ENOG4108RFG Tetr family transcriptional regulator HVZ24_14995 ENOG4106UW1 Major Facilitator superfamily HVZ24_15000 ENOG4108HCJ Hydrolase HVZ24_15010 ENOG4107QF7 multi-drug HVZ24_15015 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase HVZ24_15020 ENOG4107FB0 transcriptional regulator DeoR family HVZ24_15025 ENOG4105DZ1 carboxypeptidase HVZ24_15030 ENOG4108TGY Glutathione S-transferase HVZ24_15035 ENOG4105D8V Glucose sorbosone dehydrogenase HVZ24_15040 ENOG4105UFT Represses biofilm formation in M9C glu and LB glu media but not in M9C and LB media. Seems to act as a global regulator of several genes involved in catabolite repression and stress response and regulation of the uptake and export of signaling pathways. Could be involved the regulation of indole as well as uptake and export of AI-2 through a cAMP-dependent pathway HVZ24_15050 ENOG41064RH membrane protein YliF HVZ24_15055 ENOG4105BZU Histidine kinase HVZ24_15060 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HVZ24_15070 ENOG4105DEF Extracellular solute-binding protein, family 5 HVZ24_15075 ENOG4108JQ6 ABC transporter HVZ24_15080 ENOG4105D44 asparaginase HVZ24_15085 ENOG4105CVM Molybdenum cofactor synthesis domain protein HVZ24_15090 ENOG4105D06 uba thif-type nad fad binding protein HVZ24_15095 ENOG4107T9Z Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) HVZ24_15100 ENOG4105F1A Pyruvate formate-lyase HVZ24_15110 ENOG4108HCJ Hydrolase HVZ24_15115 ENOG41072TH Protein of unknown function (DUF1479) HVZ24_15120 ENOG4105C5H ABC transporter HVZ24_15125 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein HVZ24_15130 ENOG4105F4P )-transporter HVZ24_15135 ENOG4105KST dependent repressor HVZ24_15145 ENOG4108I6E Sulfatase HVZ24_15150 ENOG4108T1M outer membrane protein x HVZ24_15160 ENOG4107AQZ Membrane HVZ24_15170 ENOG4107R0W ABC transporter HVZ24_15175 ENOG4105E5Q amino acid AbC transporter HVZ24_15180 ENOG4105CDA abc transporter atp-binding protein HVZ24_15185 ENOG4105D8X mechanosensitive ion channel HVZ24_15195 ENOG4105ZY9 UPF0379 protein ybiM HVZ24_15200 ENOG4108IU3 tonb-dependent siderophore receptor HVZ24_15210 ENOG4105KSC Transcriptional regulator, TraR DksA family HVZ24_15215 ENOG4105VR4 UPF0379 protein ybiJ HVZ24_15220 ENOG4105DG4 malate L-lactate dehydrogenase HVZ24_15225 ENOG4108MTB glycosyl transferase family HVZ24_15230 ENOG4105DVT helicase HVZ24_15235 ENOG4108UV1 cellular component movement HVZ24_15240 ENOG4105C1J atp-dependent rna helicase HVZ24_15245 ENOG4107MVR Transcriptional regulator HVZ24_15255 ENOG4105CJ1 ABC, transporter HVZ24_15260 ENOG4107QWP ABC-2 type transporter HVZ24_15265 ENOG4107QWP ABC-2 type transporter HVZ24_15270 ENOG4105I9U inner membrane protein ybhQ HVZ24_15275 ENOG4105X23 Endonuclease Exonuclease phosphatase HVZ24_15280 ENOG4105DZQ phospholipase D Transphosphatidylase HVZ24_15285 ENOG4107UXM Membrane HVZ24_15290 ENOG410733J conserved inner membrane protein HVZ24_15295 ENOG4105HFZ Membrane HVZ24_15300 ENOG4108ZAF Molybdopterin HVZ24_15305 ENOG4105M00 molybdopterin converting factor, subunit 1 HVZ24_15315 ENOG4108RIR Molybdenum cofactor biosynthesis protein HVZ24_15320 ENOG4105CM1 Catalyzes, together with MoaC, the conversion of 5'-GTP to cyclic pyranopterin monophosphate (cPMP or molybdopterin precursor Z) (By similarity) HVZ24_15325 ENOG4105CHW UPF0052 protein HVZ24_15335 ENOG4105E78 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) HVZ24_15340 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) HVZ24_15345 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) HVZ24_15355 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) HVZ24_15360 ENOG4108V1U phospholipid-binding protein HVZ24_15365 ENOG4105IHM Involved in O antigen modification. Involved in the translocation of bactoprenol-linked glucose across the cytoplasmic membrane (By similarity) HVZ24_15370 ENOG4105CKK Glycosyl transferase, family 2 HVZ24_15440 ENOG41077V0 CPS-53 (KpLE1) prophage HVZ24_15475 ENOG4108I1J Integrase HVZ24_15480 ENOG4105NBR Pectinesterase HVZ24_15490 ENOG4107QPK )-transporter HVZ24_15495 ENOG4105C7F AcnD-accessory protein PrpF HVZ24_15500 ENOG4105F04 LysR family Transcriptional regulator HVZ24_15510 ENOG4108K4B hydrolase HVZ24_15515 ENOG4105CGB Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system (By similarity) HVZ24_15520 ENOG4105E0C molybdate abc transporter HVZ24_15525 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein HVZ24_15535 ENOG4105F4R Transcriptional regulator mode HVZ24_15540 ENOG4105DKW ABC transporter HVZ24_15545 ENOG4105CMR udp-glucose 4-epimerase HVZ24_15550 ENOG4105F0Z galactose-1-phosphate uridylyltransferase HVZ24_15560 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) HVZ24_15570 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) HVZ24_15575 ENOG4105JND homeobox protein HVZ24_15580 ENOG4105PGM cation diffusion facilitator family transporter HVZ24_15585 ENOG4106Z1T Nicotinamide Mononucleotide Transporter HVZ24_15590 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) HVZ24_15635 ENOG4105UFD tol-pal system protein YbgF HVZ24_15640 ENOG4105KCK Peptidoglycan-associated lipoprotein HVZ24_15650 ENOG4108Z82 Cell envelope integrity inner membrane protein TolA HVZ24_15660 ENOG4105E02 MotA TolQ exbB proton channel HVZ24_15665 ENOG4107YD3 Thioesterase HVZ24_15670 ENOG4105KJB cyd operon protein YbgE HVZ24_15680 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii HVZ24_15685 ENOG4105C4M (Ubiquinol oxidase) subunit I HVZ24_15690 ENOG4105C8I hydrolase, family 38 HVZ24_15695 ENOG4105DM4 PTS System HVZ24_15700 ENOG4105FDP GntR family transcriptional regulator HVZ24_15705 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha HVZ24_15715 ENOG4105C7S Dehydrogenase HVZ24_15720 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 HVZ24_15725 ENOG4105E33 succinate dehydrogenase HVZ24_15730 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) HVZ24_15735 ENOG4105N1I succinate dehydrogenase, hydrophobic membrane anchor protein HVZ24_15740 ENOG4108UTY succinate dehydrogenase, cytochrome b556 subunit HVZ24_15750 ENOG4105BZN citrate synthase HVZ24_15755 ENOG4106UBK fimbrial-like adhesin protein HVZ24_15760 ENOG4106PG1 outer membrane usher protein HVZ24_15765 ENOG4108TTM chaperone HVZ24_15770 ENOG4108MY7 Fimbrial HVZ24_15775 ENOG4108KK1 membrane protein AbrB duplication HVZ24_15780 ENOG4108S0J Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized pyrimidines, such as thymine glycol, 5,6-dihydrouracil and 5,6-dihydrothymine. Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'- phosphates (By similarity) HVZ24_15785 ENOG4105E7W lamb ycsf family protein HVZ24_15790 ENOG4107R7A Allophanate hydrolase subunit 2 HVZ24_15795 ENOG4105P4J Allophanate hydrolase, subunit 1 HVZ24_15800 ENOG4107QNR UPF0135 protein HVZ24_15805 ENOG4105DUX Transporter HVZ24_15810 ENOG4105CVP deoxyribo-dipyrimidine photolyase HVZ24_15815 ENOG4107SEY Conserved Protein HVZ24_15835 ENOG4106R09 HVZ24_15840 ENOG4105CNA YD repeat protein HVZ24_15845 ENOG41079JQ Membrane HVZ24_15850 ENOG4105CNA YD repeat protein HVZ24_15855 ENOG4105XIQ Protein of unknown function (DUF2517) HVZ24_15870 ENOG4105C8X One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) HVZ24_15875 ENOG4108R80 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity) HVZ24_15880 ENOG4105C08 Histidine kinase HVZ24_15885 ENOG4105EEX Two component transcriptional regulator (Winged helix family HVZ24_15895 ENOG4105CXN decarboxylase HVZ24_15900 ENOG4105D5Q Arginine ornithine antiporter HVZ24_15920 ENOG4107QIX Phosphoglucomutase (EC 5.4.2.2 HVZ24_15925 ENOG4107CDU Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated (By similarity) HVZ24_15930 ENOG4105EV9 Alpha Beta Hydrolase HVZ24_15935 ENOG4105NNH LexA regulated protein HVZ24_15940 ENOG4105MHQ Low-potential electron donor to a number of redox enzymes (By similarity) HVZ24_15950 ENOG41090R7 Ferric uptake HVZ24_15955 ENOG4105GX6 (LipO)protein HVZ24_15970 ENOG4105CI1 PTS System HVZ24_15980 ENOG4105CE4 GlcNAc 6-P deacetylase HVZ24_15985 ENOG4105E2R ROK family HVZ24_15990 ENOG4105D4U had-superfamily hydrolase, subfamily iia HVZ24_15995 ENOG4105CAQ asparagine synthetase HVZ24_16035 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family HVZ24_16045 ENOG4105C9A Phoh family HVZ24_16055 ENOG4108JU5 Magnesium and cobalt efflux protein HVZ24_16060 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) HVZ24_16065 ENOG4107RP9 extracellular solute-binding protein, family 3 HVZ24_16070 ENOG4105EAD ABC transporter HVZ24_16075 ENOG4105DRP amino acid AbC transporter HVZ24_16080 ENOG4105CDA abc transporter atp-binding protein HVZ24_16090 ENOG4105F7F Chaperone HVZ24_16095 ENOG4105QFC Hsc56 co-chaperone of HscC HVZ24_16100 ENOG41069CF Protein of unknown function (DUF1266) HVZ24_16105 ENOG4107JFD Sel1 repeat HVZ24_16110 ENOG4105QFC Hsc56 co-chaperone of HscC HVZ24_16115 ENOG41069CF Protein of unknown function (DUF1266) HVZ24_16120 ENOG4105EUU Sel1 domain protein repeat-containing protein HVZ24_16125 ENOG4107PAI alpha helical protein HVZ24_16140 ENOG4105DJF DNA polymerase III, delta' subunit HVZ24_16150 ENOG4108TGR phosphatase HVZ24_16155 ENOG4105KEM Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) HVZ24_16165 ENOG4105CJN penicillin-binding protein HVZ24_16170 ENOG4105CNI cell division protein FtsW HVZ24_16175 ENOG4105K6T rare lipoprotein A HVZ24_16180 ENOG4105DZ1 carboxypeptidase HVZ24_16195 ENOG41064T2 transcriptional regulator, lysR family HVZ24_16205 ENOG410607N Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatE shares overlapping functions with TatA (By similarity) HVZ24_16225 ENOG41079UR PagP is required both for biosynthesis of hepta-acylated lipid A species containing palmitate and for resistance to cationic antimicrobial peptides (CAMPs). It catalyzes the transfer of a palmitate chain (16 0) from the sn-1 position of a glycerophospholipid to the free hydroxyl group of the (R)-3- hydroxymyristate chain at position 2 of lipid A (endotoxin) (By similarity) HVZ24_16230 ENOG4105CEE C4-dicarboxylate transporter HVZ24_16235 ENOG4106YYS transcriptional regulatory protein HVZ24_16240 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism HVZ24_16245 ENOG4105DUA (citrate (pro-3S)-lyase ligase HVZ24_16255 ENOG4105CI0 Citrate lyase HVZ24_16260 ENOG4105CHY citrate lyase, alpha HVZ24_16275 ENOG4107QPK )-transporter HVZ24_16280 ENOG4105KTS ribonuclease HVZ24_16285 ENOG4105NXH GreA GreB family elongation factor HVZ24_16290 ENOG4105E2A Dehydrogenase HVZ24_16295 ENOG4108U51 Universal stress protein HVZ24_16300 ENOG4108JU3 Alkyl hydroperoxide reductase HVZ24_16305 ENOG4105D3R alkyl hydroperoxide reductase HVZ24_16310 ENOG4108KHN disulfide isomerase, thiol-disulfide oxidase HVZ24_16315 ENOG4105DQS Transcriptional regulator HVZ24_16320 ENOG4105BZV Phosphoadenosine phosphosulfate reductase HVZ24_16325 ENOG4105GTN ParB Domain Protein Nuclease HVZ24_16330 ENOG4105CHM Aminotransferase HVZ24_16335 ENOG4107SCQ Iron-containing alcohol dehydrogenase HVZ24_16340 ENOG4105VCD cytoplasmic protein HVZ24_16345 ENOG4105D22 carbon starvation protein HVZ24_16350 ENOG4108TZA Required for optimal enterobactin synthesis. Acts as a proofreading enzyme that prevents EntB misacylation by hydrolyzing the thioester bound existing between EntB and wrongly charged molecules (By similarity) HVZ24_16355 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase HVZ24_16360 ENOG4105WQI isochorismatase HVZ24_16365 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase HVZ24_16370 ENOG4105E4F Isochorismate synthase HVZ24_16375 ENOG4105PEC Iron-enterobactin transporter periplasmic binding protein HVZ24_16385 ENOG4105DQ5 transport system permease protein HVZ24_16390 ENOG4105TVJ transport system, permease HVZ24_16395 ENOG4105E0A ABC, transporter HVZ24_16400 ENOG4108QY5 Ferric enterobactin transport protein HVZ24_16405 ENOG4105C0W non-ribosomal peptide synthetase HVZ24_16410 ENOG41085A6 mbth domain-containing protein HVZ24_16415 ENOG4105E93 esterase HVZ24_16420 ENOG4107RNH Outer membrane receptor FepA HVZ24_16425 ENOG4108TSE Transferase HVZ24_16430 ENOG4108SER Transposase HVZ24_16435 ENOG4107635 Hok Gef family protein HVZ24_16440 ENOG4106KXD ATP-dependent carboxylate-amine ligase (By similarity) HVZ24_16445 ENOG4105WQ6 Membrane HVZ24_16450 ENOG4105MSB protein, conserved in bacteria HVZ24_16455 ENOG4108RCM Nitroreductase HVZ24_16460 ENOG4105CUY Mechanosensitive ion channel HVZ24_16465 ENOG4105C85 amino acid HVZ24_16470 ENOG4108IJF Heavy metal efflux pump, CzcA HVZ24_16475 ENOG4105EP1 Efflux transporter rnd family, mfp subunit HVZ24_16480 ENOG410624V efflux system protein HVZ24_16485 ENOG4105ENJ RND efflux system, outer membrane lipoprotein HVZ24_16490 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HVZ24_16495 ENOG4105GR3 Histidine kinase HVZ24_16500 ENOG410802X bacteriophage n4 adsorption protein b HVZ24_16505 ENOG41090FC Bacteriophage N4 receptor, outer membrane subunit HVZ24_16510 ENOG4105QUW HVZ24_16520 ENOG4108NC2 Outer membrane protease HVZ24_16525 ENOG4108MIW Induces the synthesis of acid phosphatase (AppA) and several other polypeptides (such as AppBC) during the deceleration phase of growth. It also acts as a transcriptional repressor for one group of proteins that are synthesized preferentially in exponential growth and for one group synthesized only in the stationary phase. Also involved in the stabilization of the sigma stress factor RpoS during stress conditions HVZ24_16540 ENOG4105FKG DNA packaging protein HVZ24_16545 ENOG4106YSC HVZ24_16560 ENOG4105QYK bacteriophage lambda Bor protein homolog HVZ24_16570 ENOG4105KUS lysozyme HVZ24_16575 ENOG4105QFS Lysis protein S homolog from lambdoid prophage HVZ24_16585 ENOG4105HRS Antitermination protein HVZ24_16600 ENOG4105RWQ Protein of unknown function (DUF1364) HVZ24_16605 ENOG410757E Protein NinE homolog from lambdoid prophage DLP12 HVZ24_16610 ENOG4108V2F protein ybcN in lambdoid DLP12 prophage regi HVZ24_16620 ENOG4108UQN AraC family transcriptional regulator HVZ24_16625 ENOG4108V1U phospholipid-binding protein HVZ24_16630 ENOG4107TII Recombinase HVZ24_16640 ENOG410814C multidrug resistance protein HVZ24_16665 ENOG4108Q9V regulatoR HVZ24_16670 ENOG4108ZI2 Fimbrial protein HVZ24_16675 ENOG4108M66 Involved in regulation of length and mediation of adhesion of SfmA fimbriae (but not necessary for the production of fimbriae). Seems to be mannose binding adhesin (By similarity) HVZ24_16680 ENOG4105CW0 outer membrane usher protein HVZ24_16685 ENOG4108AF8 Chaperone HVZ24_16690 ENOG4108WDE Fimbrial protein HVZ24_16695 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) HVZ24_16700 ENOG4105WQ3 Rna-binding protein HVZ24_16705 ENOG4105S2T inner membrane protein YbcI HVZ24_16710 ENOG4105C8N cysteinyl-tRNA synthetase HVZ24_16715 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) HVZ24_16725 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) HVZ24_16730 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit HVZ24_16735 ENOG4105C5B carbamate kinase HVZ24_16740 ENOG4105G5A Protein of unknown function (DUF2877) HVZ24_16745 ENOG4107REC cytoplasmic protein HVZ24_16750 ENOG4107R1Q Membrane protein FdrA HVZ24_16755 ENOG4105DG4 malate L-lactate dehydrogenase HVZ24_16760 ENOG4105CE7 Amidase, hydantoinase carbamoylase family HVZ24_16765 ENOG4105S0E allantoin catabolism protein HVZ24_16770 ENOG4105BZW Glycerate kinase HVZ24_16775 ENOG4105DTE Xanthine uracil vitamin C permease HVZ24_16780 ENOG4105CD3 dihydroorotase HVZ24_16785 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease HVZ24_16790 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase HVZ24_16795 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) HVZ24_16800 ENOG41060W2 glyoxylate carboligase HVZ24_16805 ENOG4108N16 Negative regulator of allantoin and glyoxylate utilization operons. Binds to the gcl promoter and to the allS- allA intergenic region HVZ24_16815 ENOG4107653 Transcriptional regulator HVZ24_16820 ENOG4105CR7 Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA (By similarity) HVZ24_16850 ENOG4105CNA YD repeat protein HVZ24_16855 ENOG4105CV6 ABC transporter, permease HVZ24_16860 ENOG4108I0Y (ABC) transporter HVZ24_16865 ENOG4108UJV acyl-CoA thioesterase i HVZ24_16870 ENOG4105E1F short-chain dehydrogenase reductase HVZ24_16875 ENOG4107QR8 Thioredoxin HVZ24_16880 ENOG4105C4B ABC transporter, permease HVZ24_16885 ENOG41083J0 (ABC) transporter HVZ24_16890 ENOG4107QX8 SPFH domain, Band 7 family protein HVZ24_16895 ENOG4105G5H Membrane HVZ24_16900 ENOG4108Z6Z Transcriptional regulator HVZ24_16905 ENOG4107RY6 amino acid HVZ24_16910 ENOG4105CSV Glutaminase HVZ24_16915 ENOG4105C59 p-type ATPase HVZ24_16920 ENOG41081XE plasmid maintenance system antidote protein, xre family HVZ24_16925 ENOG4105MBR gumn family HVZ24_16930 ENOG4108Z66 YbaK ebsC protein HVZ24_16935 ENOG4105CGH 5'-nucleotidase HVZ24_16940 ENOG4105EU0 Major facilitator Superfamily HVZ24_16945 ENOG4105CKD glutathione-regulated potassium-efflux system protein HVZ24_16950 ENOG4107RE1 Inosine-guanosine kinase HVZ24_16960 ENOG4105CFX Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) HVZ24_16985 ENOG4107QMP dna polymerase iii subunits gamma and tau HVZ24_16995 ENOG4105WD1 Membrane HVZ24_17000 ENOG4108URS primosomal replication protein n'' HVZ24_17005 ENOG4106428 Protein of unknown function (DUF2496) HVZ24_17010 ENOG4105EGS Mechanosensitive ion channel HVZ24_17015 ENOG4107XI7 Tetr family transcriptional regulator HVZ24_17020 ENOG4105C1P efflux transporter, rnd family, mfp subunit HVZ24_17025 ENOG4105BZS acriflavin resistance protein HVZ24_17030 ENOG4108UKR Biofilm formation regulator YbaJ HVZ24_17035 ENOG4105KF5 hemolysin expression-modulating protein HVZ24_17040 ENOG4108UW5 maltose o-acetyltransferase HVZ24_17045 ENOG4105GSJ Inner membrane protein ylaC HVZ24_17055 ENOG41066DG (EAL) domain protein HVZ24_17060 ENOG4105KCV RNA signal recognition particle 4.5S RNA HVZ24_17070 ENOG41080UX Methyltransferase HVZ24_17075 ENOG4108MNP Glycoprotein polysaccharide metabolism HVZ24_17080 ENOG4105C29 acyl-CoA thioesterase HVZ24_17085 ENOG4105BZU Histidine kinase HVZ24_17090 ENOG4108YZA Nitrogen regulatory protein pii HVZ24_17095 ENOG4105BZ1 (ABC) transporter HVZ24_17100 ENOG4105BZ1 (ABC) transporter HVZ24_17105 ENOG4108XM1 transcriptional regulator AsnC family HVZ24_17110 ENOG4108AZI Catalyzes the hydrolysis of 4-amino-2-methyl-5- hydroxymethylpyrimidine pyrophosphate (HMP-PP) to 4-amino-2- methyl-5-hydroxymethylpyrimidine phosphate (HMP-P) (By similarity) HVZ24_17115 ENOG4108NFA extracellular solute-binding protein HVZ24_17120 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) HVZ24_17125 ENOG4108TGP Thioesterase superfamily protein HVZ24_17130 ENOG41083P1 competence protein ComEA helix-hairpin-helix repeat protein HVZ24_17135 ENOG4105EIN peptidylprolyl cis-trans isomerase HVZ24_17140 ENOG4105K70 DNA-binding protein HVZ24_17145 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) HVZ24_17165 ENOG4105M85 Bola protein HVZ24_17170 ENOG4105IEY (LipO)protein HVZ24_17175 ENOG4105EYM Major Facilitator superfamily HVZ24_17180 ENOG4105E2S oxidase) subunit II HVZ24_17185 ENOG4105BZ9 Cytochrome C oxidase, subunit I HVZ24_17190 ENOG4105CCU oxidase (Subunit III) HVZ24_17195 ENOG41090KH cytochrome o ubiquinol oxidase (subunit iv) HVZ24_17205 ENOG4107RDB Major Facilitator HVZ24_17215 ENOG4108JZF Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) HVZ24_17220 ENOG4107S0N DJ-1 family HVZ24_17225 ENOG4105D8I Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity) HVZ24_17235 ENOG4105CTB Polyprenyl synthetase HVZ24_17240 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) HVZ24_17245 ENOG4105CPC Aldo Keto reductase HVZ24_17250 ENOG4108ZAI phosphatidylglycerophosphatase a HVZ24_17255 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) HVZ24_17265 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) HVZ24_17270 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) HVZ24_17280 ENOG4108KIC (LipO)protein HVZ24_17285 ENOG4105DRB nucleoside-specific channel-forming protein HVZ24_17290 ENOG4105N1F Hnh endonuclease HVZ24_17295 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) HVZ24_17300 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) HVZ24_17305 ENOG4105VIE preprotein translocase, subunit YajC HVZ24_17320 ENOG4108ZYK Acyl carrier protein phosphodiesterase HVZ24_17325 ENOG4107R28 alpha amylase, catalytic region HVZ24_17330 ENOG4105C85 amino acid HVZ24_17335 ENOG4105CWM branched-chain amino acid transport system II carrier protein HVZ24_17340 ENOG4105BZU Histidine kinase HVZ24_17345 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HVZ24_17350 ENOG4107RH8 nuclease SbcCD subunit D HVZ24_17355 ENOG4105EYH Exonuclease HVZ24_17360 ENOG4105F27 Major Facilitator HVZ24_17365 ENOG4105DKQ ROK family HVZ24_17390 ENOG4105HBA AroM protein HVZ24_17395 ENOG4105SS3 HVZ24_17410 ENOG4105II7 pyrroline-5-carboxylate reductase HVZ24_17415 ENOG4105BZU Histidine kinase HVZ24_17420 ENOG4105VIF phosphate starvation-inducible protein HVZ24_17425 ENOG4105G6Z alkaline phosphatase HVZ24_17440 ENOG4105CPF Cell wall formation (By similarity) HVZ24_17445 ENOG4105UNH Membrane HVZ24_17450 ENOG4105FR5 inner membrane protein YaiY HVZ24_17455 ENOG4107QS8 (LipO)protein HVZ24_17460 ENOG4108DQG in Escherichia coli SbmA is involved in uptake of microcin J25 HVZ24_17465 ENOG4107R6D beta-lactam binding protein AmpH HVZ24_17470 ENOG4108PNB DNA-binding transcriptional regulator HVZ24_17480 ENOG4105D52 delta-aminolevulinic acid dehydratase HVZ24_17485 ENOG4105E2B Taurine dioxygenase HVZ24_17490 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component HVZ24_17500 ENOG4106FTQ Taurine ABC transporter, periplasmic HVZ24_17505 ENOG4107W19 lmbE family HVZ24_17510 ENOG4108PBI Polysaccharide metabolism HVZ24_17520 ENOG4105SRB Uncharacterized protein yaiO HVZ24_17535 ENOG4105C4W S-formylglutathione hydrolase HVZ24_17540 ENOG4105IUQ nucleoprotein polynucleotide-associated enzyme HVZ24_17545 ENOG4108SC4 )-transporter HVZ24_17560 ENOG4105IKQ hydratase HVZ24_17565 ENOG4106HB6 Alpha beta hydrolase HVZ24_17575 ENOG4105E2Q 3-(3-hydroxy-phenyl)propionate hydroxylase HVZ24_17580 ENOG4108K2P TRANSCRIPTIONal HVZ24_17585 ENOG4105ETE Transcriptional regulator (LacI family HVZ24_17590 ENOG4105CNT hydrolase family 2 HVZ24_17595 ENOG4105U0F oligosaccharide H symporter, major facilitator superfamily (MFS) HVZ24_17600 ENOG4108UW5 maltose o-acetyltransferase HVZ24_17605 ENOG4105DJ2 Major Facilitator Superfamily HVZ24_17610 ENOG4108V7B Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide (By similarity) HVZ24_17615 ENOG4107B2H carbonic anhydrase HVZ24_17620 ENOG4105DND Transcriptional regulator HVZ24_17625 ENOG4105DZC cytosine deaminase HVZ24_17630 ENOG4105DQW permease for cytosine purines, uracil, thiamine, allantoin HVZ24_17635 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) HVZ24_17640 ENOG4105DXD 2-methylcitrate dehydratase HVZ24_17645 ENOG4105BZN citrate synthase HVZ24_17650 ENOG4105CR4 methylisocitrate lyase HVZ24_17660 ENOG4105TDT uncharacterized protein yahO HVZ24_17665 ENOG4105E82 cytochrome subunit of dehydrogenase HVZ24_17680 ENOG4105DQ4 alcohol dehydrogenase HVZ24_17685 ENOG4105DZC cytosine deaminase HVZ24_17690 ENOG4105C5B carbamate kinase HVZ24_17700 ENOG4107REC cytoplasmic protein HVZ24_17705 ENOG4107R1Q Membrane protein FdrA HVZ24_17710 ENOG4105N16 Protein of unknown function (DUF2877) HVZ24_17715 ENOG4107SNB ankyrin repeat protein YahD HVZ24_17720 ENOG4105SZ2 membrAne HVZ24_17725 ENOG4108NUU Transcriptional regulator HVZ24_17730 ENOG4105BZU Histidine kinase HVZ24_17740 ENOG4105C94 Transporter HVZ24_17745 ENOG4108MHR Repressor involved in choline regulation of the bet genes (By similarity) HVZ24_17750 ENOG4105C26 Dehydrogenase HVZ24_17755 ENOG4105CZ6 Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine (By similarity) HVZ24_17765 ENOG4108ZZK Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source (By similarity) HVZ24_17770 ENOG4107QR9 Iron-sulfur cluster binding protein HVZ24_17775 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) HVZ24_17780 ENOG4108K01 transcriptional regulator HVZ24_17785 ENOG4107QN2 dihydrolipoyl dehydrogenase HVZ24_17790 ENOG41066GK UPF0379 protein ykgI HVZ24_17795 ENOG4108KBJ Inner membrane protein YkgB HVZ24_17835 ENOG4106JB4 Represses expression of the flagellar master operon flhDC, and consequently prevents flagellum biosynthesis and motility. Acts by binding to the regulatory region of the flhDC operon HVZ24_17840 ENOG4108GWT fimbrillin MatB HVZ24_17850 ENOG4108N3D putative enzyme HVZ24_17855 ENOG4106PYX Receptor HVZ24_17860 ENOG4108UD7 cell wall organization HVZ24_17865 ENOG4105PI0 Ferredoxin HVZ24_17870 ENOG4105R3P Inner membrane protein yagU HVZ24_17875 ENOG4107XKX isoquinoline 1-oxidoreductase, alpha subunit HVZ24_17880 ENOG4105DIP Molybdopterin dehydrogenase FAD-binding HVZ24_17885 ENOG4105C7W Xanthine dehydrogenase HVZ24_17890 ENOG4107XAN XdhC and CoxI family HVZ24_17920 ENOG4105D3Q Sugar transferase HVZ24_17955 ENOG41088YS Glycosyl transferase (Group 1 HVZ24_17960 ENOG4107RA4 Glycosyl transferase (Group 1 HVZ24_17975 ENOG4105CMR udp-glucose 4-epimerase HVZ24_18035 ENOG4105VDM plasmid maintenance system antidote protein, xre family HVZ24_18060 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) HVZ24_18070 ENOG4105FCK Membrane HVZ24_18075 ENOG4108UVK Binds to the sigma-S subunit of RNA polymerase, activating expression of sigma-S-regulated genes. Stimulates RNA polymerase holoenzyme formation and may bind to several other sigma factors, such as sigma-70 and sigma-32 (By similarity) HVZ24_18080 ENOG4105V1F Fermentation respiration switch protein HVZ24_18090 ENOG4105CIN aminoacyl-histidine dipeptidase HVZ24_18095 ENOG4108S2Y peptide Chain Release factor HVZ24_18105 ENOG4108HYG acetyltransferase HVZ24_18110 ENOG41065DM this blockage is overcome by subsequent expression of antitoxin YafN. Overexpression causes cleavage of a number of mRNAs in a ribosome-dependent fashion. YafO binding to the 50S ribosomal subunit in the translation complex induces mRNA cleavage 3' to the region protected by the ribosome HVZ24_18115 ENOG4105UG9 Antitoxin of the YafO-YafN toxin-antitoxin system HVZ24_18120 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) HVZ24_18135 ENOG4108UK5 Transposase HVZ24_18140 ENOG4108YS0 lipoprotein YafL HVZ24_18145 ENOG4105QHH Antitoxin component of a toxin-antitoxin (TA) module. A labile antitoxin that counteracts the effect of the YafQ toxin. YafQ and DinJ together bind their own promoter, and by analogy to other TA modules probably repress its expression HVZ24_18150 ENOG4105VXN addiction module toxin, RelE StbE family HVZ24_18155 ENOG4105F7V ErfK ybiS ycfS ynhG family protein HVZ24_18160 ENOG4105E7A Glutamine amidotransferase HVZ24_18170 ENOG4107QPN acyl-Coa dehydrogenase HVZ24_18175 ENOG4108WN0 inhibitor of vertebrate lysozyme HVZ24_18180 ENOG4105CZ7 nitrilase cyanide hydratase and apolipoprotein n-acyltransferase HVZ24_18185 ENOG410600T transposase HVZ24_18195 ENOG4105CNA YD repeat protein HVZ24_18210 ENOG4105GMB type VI secretion system effector, hcp1 family HVZ24_18225 ENOG410600K aminopeptidase HVZ24_18235 ENOG4107RZZ dna polymerase iii epsilon subunit HVZ24_18245 ENOG4105D1A Methyltransferase HVZ24_18250 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) HVZ24_18255 ENOG4105E9H Lytic Murein transglycosylase HVZ24_18270 ENOG4105HEI LysR family (Transcriptional regulator HVZ24_18275 ENOG4105CV8 reductase HVZ24_18310 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase HVZ24_18315 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) HVZ24_18320 ENOG4108UMI ABC transporter, permease HVZ24_18325 ENOG4105D01 (LipO)protein HVZ24_18330 ENOG4108R8X outer membrane lipoprotein HVZ24_18335 ENOG4108R96 Methyltransferase, YaeB family HVZ24_18345 ENOG4108UY0 (LipO)protein HVZ24_18350 ENOG4107EII Lipoprotein involved with copper homeostasis and adhesion HVZ24_18355 ENOG4108YZN class I peptide chain release factor HVZ24_18360 ENOG4108VWS Yaeq family HVZ24_18370 ENOG4105M1T rho-binding antiterminator HVZ24_18375 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) HVZ24_18380 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase HVZ24_18385 ENOG4105CXN decarboxylase HVZ24_18395 ENOG4105C0B DNA polymerase III (alpha subunit) HVZ24_18420 ENOG4105D7M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) HVZ24_18425 ENOG4108RFI Molecular chaperone that interacts specifically with outer membrane proteins, thus maintaining the solubility of early folding intermediates during passage through the periplasm (By similarity) HVZ24_18435 ENOG4105DZP Membrane-associated zinc metalloprotease HVZ24_18440 ENOG4105KNE Phosphatidate cytidylyltransferase HVZ24_18445 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) HVZ24_18450 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) HVZ24_18475 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) HVZ24_18480 ENOG4105E1P Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity) HVZ24_18490 ENOG4105DIN metallophosphoesterase HVZ24_18500 ENOG4108IXP Carbohydrate diacid transcriptional activator CdaR HVZ24_18505 ENOG4105C0H protease HVZ24_18520 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) HVZ24_18525 ENOG4105EN6 Membrane HVZ24_18550 ENOG4105S6R Iron-hydroxamate transporter permease subunit HVZ24_18555 ENOG4105J76 Periplasmic binding protein HVZ24_18560 ENOG4105E0A ABC, transporter HVZ24_18565 ENOG4105E0K tonB-dependent siderophore receptor HVZ24_18570 ENOG4105BZ4 penicillin-binding protein HVZ24_18575 ENOG4105CQ7 ATP-dependent helicase HVZ24_18580 ENOG4107XID 2'-5' rna ligase HVZ24_18600 ENOG4105DJ0 Poly(A) Polymerase HVZ24_18605 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase HVZ24_18615 ENOG4108VEV chaperone HVZ24_18620 ENOG4105CW0 outer membrane usher protein HVZ24_18625 ENOG4108XEY fimbrial-like adhesin protein HVZ24_18630 ENOG4105SYG Fimbrial protein HVZ24_18635 ENOG4105SN2 fimbrial-like adhesin protein HVZ24_18640 ENOG4105P0Q fimbrial-like protein YadC HVZ24_18645 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) HVZ24_18655 ENOG4108A32 Transposase HVZ24_18665 ENOG4107BJW polysaccharide deacetylase HVZ24_18670 ENOG4108YTN IIa component HVZ24_18675 ENOG4105E3A (ABC) transporter HVZ24_18680 ENOG4105DA5 (ABC) transporter HVZ24_18685 ENOG41077A9 carbonic anhydrase HVZ24_18690 ENOG4108UGV hypoxanthine phosphoribosyltransferase HVZ24_18695 ENOG4105DZG Dehydrogenase HVZ24_18700 ENOG4105E3B Multicopper oxidase HVZ24_18705 ENOG4108ZRK uncharacterized protein yacC HVZ24_18725 ENOG4107QIJ Aconitate hydratase 2 HVZ24_18730 ENOG4108NST exported protein HVZ24_18735 ENOG4107QN2 dihydrolipoyl dehydrogenase HVZ24_18740 ENOG4107QSN dihydrolipoamide acetyltransferase HVZ24_18745 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) HVZ24_18750 ENOG41073TP transcriptional regulator HVZ24_18755 ENOG4105C85 amino acid HVZ24_18760 ENOG4106A72 regulatory protein AmpE HVZ24_18765 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase HVZ24_18770 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase HVZ24_18775 ENOG4108ZUW Major pilin subunit HVZ24_18780 ENOG4107QHF type ii secretion system protein e HVZ24_18785 ENOG4105D7Q type ii secretion system HVZ24_18800 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) HVZ24_18815 ENOG4105M6F mutator MutT protein HVZ24_18825 ENOG4108SR7 Regulates secA expression by translational coupling of the secM secA operon. Translational pausing at a specific Pro residue 5 residues before the end of the protein may allow disruption of a mRNA repressor helix that normally suppresses secA translation initiation (By similarity) HVZ24_18835 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) HVZ24_18840 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) HVZ24_18845 ENOG4105K7E Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity) HVZ24_18850 ENOG4105CPF Cell wall formation (By similarity) HVZ24_18855 ENOG4105DFU Cell wall formation (By similarity) HVZ24_18860 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) HVZ24_18865 ENOG4105CNI cell division protein FtsW HVZ24_18870 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) HVZ24_18880 ENOG4108EQQ Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity) HVZ24_18885 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) HVZ24_18890 ENOG4105CJN penicillin-binding protein HVZ24_18895 ENOG41063Y6 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) HVZ24_18905 ENOG4108V6E Cell division protein mraZ HVZ24_18910 ENOG4107B7Y DNA-binding transcriptional regulator FruR HVZ24_18920 ENOG4108ZP8 Acetolactate synthase small subunit HVZ24_18925 ENOG4105C7K acetolactate synthase HVZ24_18935 ENOG41064T2 transcriptional regulator, lysR family HVZ24_18950 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) HVZ24_18965 ENOG4105S8Q sugar efflux transporter HVZ24_18975 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) HVZ24_18980 ENOG4105DP9 ABC transporter HVZ24_18985 ENOG4106SMU thiamine transporter membrane protein HVZ24_18990 ENOG4107T0D ABC, transporter HVZ24_18995 ENOG4108KF1 Membrane HVZ24_19000 ENOG41063TF transcriptional regulator (AraC HVZ24_19005 ENOG4105EF1 ribulokinase HVZ24_19010 ENOG4105CAC Catalyzes the conversion of L-arabinose to L-ribulose (By similarity) HVZ24_19015 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase HVZ24_19020 ENOG4105CQ2 DNA polymerase HVZ24_19025 ENOG4105BZK Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair (By similarity) HVZ24_19030 ENOG4105D3G Pseudouridine synthase HVZ24_19050 ENOG41066UG Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host (By similarity) HVZ24_19055 ENOG4105E7H involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity) HVZ24_19060 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) HVZ24_19065 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) HVZ24_19080 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) HVZ24_19085 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) HVZ24_19090 ENOG4105CKD glutathione-regulated potassium-efflux system protein HVZ24_19100 ENOG4105C54 Major Facilitator superfamily HVZ24_19105 ENOG4105IBM Could be part of an electron transfer system required for anaerobic carnitine reduction. Could be a 3Fe-4S cluster- containing protein HVZ24_19110 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase HVZ24_19115 ENOG4105C10 Electron transfer flavoprotein HVZ24_19135 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F HVZ24_19145 ENOG4106YT9 Enoyl-CoA hydratase HVZ24_19155 ENOG4108XNW Transcriptional activatory protein CaiF HVZ24_19160 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain HVZ24_19165 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain HVZ24_19185 ENOG41090X3 Peptidyl-prolyl cis-trans isomerase HVZ24_19200 ENOG4105DTN riboflavin biosynthesis protein ribF HVZ24_19205 ENOG410647N response to DNA damage stimulus HVZ24_19230 ENOG41063Z6 transcriptional regulator, lysR family HVZ24_19240 ENOG4105WI6 cell killing protein encoded within cryptic prophage HVZ24_19245 ENOG4108SER Transposase HVZ24_19265 ENOG4108QUJ UPF0174 protein YaaW HVZ24_19270 ENOG4106HK8 GPR1 FUN34 yaaH family protein HVZ24_19275 ENOG4108RIR Molybdenum cofactor biosynthesis protein HVZ24_19285 ENOG4105BZG amino acid carrier protein HVZ24_19295 ENOG41062C6 Protein of unknown function (DUF2502) HVZ24_19300 ENOG4105D98 threonine synthase HVZ24_19310 ENOG4105CFH Aspartokinase HVZ24_19320 ENOG4106FVC RNA methyltransferase HVZ24_19325 ENOG410759A HVZ24_19330 ENOG41065U4 response regulator HVZ24_19335 ENOG4105CT7 inner membrane cred family protein HVZ24_19340 ENOG4105EB3 Histidine kinase HVZ24_19345 ENOG4105E3W Two component transcriptional regulator (Winged helix family HVZ24_19350 ENOG4108RH0 Crea protein HVZ24_19355 ENOG4105UEI Transcriptional Regulator AraC Family HVZ24_19365 ENOG4108K16 Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) HVZ24_19375 ENOG4107SC1 transglycosylase HVZ24_19380 ENOG4105C5H ABC transporter HVZ24_19385 ENOG4107VZS Nicotinamide-nucleotide adenylyltransferase HVZ24_19390 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) HVZ24_19395 ENOG4105EAC phosphoserine phosphatase HVZ24_19400 ENOG41062Z9 Membrane HVZ24_19415 ENOG4105D3A purine nucleoside phosphorylase DeoD-type HVZ24_19435 ENOG4105G0K glycine radical enzyme YjjI family HVZ24_19440 ENOG41076CZ activating enzyme HVZ24_19445 ENOG4105EYA deoxyribonuclease HVZ24_19450 ENOG4108NRW Phospholipase, patatin family HVZ24_19460 ENOG4105K3G Periplasmic Protein HVZ24_19470 ENOG4105PAD Hydrolase HVZ24_19475 ENOG4105KEG ribosomal-protein-alanine acetyltransferase HVZ24_19480 ENOG4108WPU DNA polymerase III subunit psi HVZ24_19485 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) HVZ24_19505 ENOG4105YBH Protein of unknown function (DUF1435) HVZ24_19510 ENOG4108819 ferric iron reductase HVZ24_19515 ENOG4108T94 DNA-binding transcriptional activator BglJ HVZ24_19520 ENOG4108N8T regulatoR HVZ24_19525 ENOG4105DWK Membrane HVZ24_19540 ENOG4106CVF DNA replication protein HVZ24_19545 ENOG4105RI1 glycoprotein receptor HVZ24_19555 ENOG4105CPQ Dehydrogenase HVZ24_19560 ENOG410617M Transcriptional regulator HVZ24_19565 ENOG4108I5G Major Facilitator superfamily HVZ24_19570 ENOG4105C8Q Methyl-accepting chemotaxis HVZ24_19575 ENOG4108V8F Transcriptional regulator, MarR family HVZ24_19580 ENOG4105ERH Fumarylacetoacetate hydrolase HVZ24_19585 ENOG4105C26 Dehydrogenase HVZ24_19590 ENOG4107THI 3,4-dihydroxyphenylacetate 2,3-dioxygenase HVZ24_19620 ENOG4105EFA 4-hydroxyphenylacetate HVZ24_19625 ENOG4107UWN reductase HVZ24_19630 ENOG4105D22 carbon starvation protein HVZ24_19635 ENOG4105VCD cytoplasmic protein HVZ24_19640 ENOG4105CKI cobalamin synthesis protein HVZ24_19650 ENOG4106DIZ Domain of unknown function (DUF1127) HVZ24_19655 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HVZ24_19665 ENOG41083G8 Multidrug resistance protein MdtM HVZ24_19670 ENOG4106BRA Membrane HVZ24_19675 ENOG4105DCU 2-hydroxyglutaryl-CoA dehydratase HVZ24_19680 ENOG4105CIZ coA-substrate-specific enzyme activase HVZ24_19695 ENOG4105CBP Major Facilitator HVZ24_19705 ENOG41074DU domain protein HVZ24_19710 ENOG4108P2H Inner membrane protein YjiG HVZ24_19715 ENOG4105DYB Isoaspartyl dipeptidase HVZ24_19720 ENOG4107YNJ LysR family Transcriptional regulator HVZ24_19740 ENOG4105C6F GntR Family Transcriptional Regulator HVZ24_19745 ENOG4105DEI Mannitol dehydrogenase HVZ24_19755 ENOG4107EFN gluconate transport system permease 3 HVZ24_19760 ENOG410643X FIMH SUBUNIT MANNOSE-sensitive type 1 fimbrial adhesin HVZ24_19765 ENOG4108T65 Fimbrial HVZ24_19770 ENOG4108SQA Fimbrial HVZ24_19775 ENOG4105CW0 outer membrane usher protein HVZ24_19780 ENOG4108NAE Fimbrial chaperone protein HVZ24_19785 ENOG4108S54 Fimbrial protein HVZ24_19790 ENOG4108RQP Major type 1 subunit fimbrin HVZ24_19795 ENOG4105E71 FimE is one of the 2 regulatory proteins which control the phase variation of type 1 fimbriae in E.coli. These proteins mediate the periodic inversion of a 300bp DNA segment that harbors the promoter for the fimbrial structural gene, fimA. FimE switches fimA off HVZ24_19800 ENOG4108W9T type 1 fimbriae regulatory protein HVZ24_19805 ENOG41069FU Outer membrane channel protein allowing the entry of N- acetylneuraminic acid (Neu5Ac, the most abundant sialic acid on host cell surfaces) into the bacteria HVZ24_19810 ENOG4108MX5 Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses (By similarity) HVZ24_19830 ENOG4105C4R Atp-dependent dna helicase HVZ24_19835 ENOG4108I5C dEAD DEAH box helicase HVZ24_19875 ENOG4105DQ4 alcohol dehydrogenase HVZ24_19880 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family HVZ24_19885 ENOG4105CPQ Dehydrogenase HVZ24_19890 ENOG4105CHR reductase HVZ24_19895 ENOG4105C6Z Gluconate HVZ24_19900 ENOG4105K2J Transcriptional regulator HVZ24_19905 ENOG4105D7A ATP-binding protein HVZ24_19910 ENOG4108K5H permease YjgP YjgQ family protein HVZ24_19915 ENOG4108M8S permease YjgP YjgQ family protein HVZ24_19925 ENOG4105MYG DNA polymerase iii, chi subunit HVZ24_19940 ENOG4108MJ3 acetyltransferase HVZ24_19945 ENOG4105KQT Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome (By similarity) HVZ24_19960 ENOG4105XEP YhcH YjgK YiaL family protein HVZ24_19965 ENOG4108XFH Transcriptional regulator HVZ24_19970 ENOG4105F6U Short-chain dehydrogenase reductase Sdr HVZ24_19975 ENOG4108UQ8 endoribonuclease L-psp HVZ24_19980 ENOG4107C93 pyrBI operon leader peptide HVZ24_19995 ENOG4105KME endoribonuclease L-psp HVZ24_20000 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic HVZ24_20010 ENOG4105D4X repressor HVZ24_20015 ENOG4105C5Y PTS System HVZ24_20020 ENOG4105CG3 alpha amylase, catalytic region HVZ24_20025 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase HVZ24_20030 ENOG4108RDD Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine (By similarity) HVZ24_20040 ENOG4105CMS peptidase U62, modulator of DNA gyrase HVZ24_20050 ENOG4105DFU Cell wall formation (By similarity) HVZ24_20060 ENOG41062B0 ABC transporter, permease HVZ24_20065 ENOG4107R9N ABC transporter HVZ24_20070 ENOG4105C2J ABC transporter HVZ24_20075 ENOG4107R5U Periplasmic binding protein LacI transcriptional regulator HVZ24_20080 ENOG4105F0N pyrophosphate phospho-hydrolase HVZ24_20085 ENOG4108ZHD aig2 family HVZ24_20090 ENOG4105MA0 exported protein HVZ24_20095 ENOG4105CFU surface antigen HVZ24_20105 ENOG4105C37 (CBS) domain HVZ24_20110 ENOG41061GZ Protein of unknown function (DUF1107) HVZ24_20115 ENOG4108UUE Transcriptional regulator HVZ24_20120 ENOG4108RNI 3'(2')5'-bisphosphate nucleotidase HVZ24_20125 ENOG4107RNS bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase 3'-nucleotidase periplasmic HVZ24_20130 ENOG4105KVH Transcriptional regulator HVZ24_20135 ENOG4105ECR NmrA family HVZ24_20140 ENOG4105DXC membrane HVZ24_20150 ENOG4105C85 amino acid HVZ24_20155 ENOG4108V1T peptidylprolyl cis-trans isomerase HVZ24_20160 ENOG4105FHY Opacity-associated protein A HVZ24_20180 ENOG4105E39 Enoyl-CoA hydratase HVZ24_20185 ENOG4107R0K CoA transferase having broad substrate specificity for short-chain acyl-CoA thioesters with the activity decreasing when the length of the carboxylic acid chain exceeds four carbons (By similarity) HVZ24_20190 ENOG4107S3R L-aspartate oxidase HVZ24_20195 ENOG41069H7 transport system small permease component HVZ24_20200 ENOG4105CG6 trap dicarboxylate transporter dctm subunit HVZ24_20205 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit HVZ24_20215 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) HVZ24_20230 ENOG4105KIT UPF0379 protein yjfY HVZ24_20235 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase HVZ24_20255 ENOG410907W The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in ascorbate transport HVZ24_20260 ENOG4105CZC PTS system ascorbate-specific transporter subunit IIC HVZ24_20275 ENOG4108MXZ Esterase HVZ24_20280 ENOG4105WSB biofilm stress and motility protein A HVZ24_20285 ENOG4105S17 UPF0379 protein yjfN HVZ24_20290 ENOG4105CSU acyl-Coa dehydrogenase HVZ24_20295 ENOG4106032 Glutathionylspermidine synthase HVZ24_20300 ENOG4108KXT Conserved Protein HVZ24_20305 ENOG4105Z6B inner membrane protein yjfl HVZ24_20310 ENOG4107VNS Protein of unknown function (DUF2491) HVZ24_20315 ENOG4108P9J Phage shock protein A HVZ24_20320 ENOG4105FUX Conserved Protein HVZ24_20325 ENOG4105C2N RNA methyltransferase TrmH family group 3 HVZ24_20330 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) HVZ24_20350 ENOG4105EPW hflc protein HVZ24_20355 ENOG4107QJR hflk protein HVZ24_20360 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) HVZ24_20375 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) HVZ24_20380 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase HVZ24_20385 ENOG4105K8N protein family UPF0079, ATPase HVZ24_20390 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) HVZ24_20395 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) HVZ24_20425 ENOG4105E06 May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity) HVZ24_20435 ENOG4105EGS Mechanosensitive ion channel HVZ24_20440 ENOG4106CG8 Inner membrane protein YjeO HVZ24_20445 ENOG4106V5W HVZ24_20450 ENOG4107SC7 Inner membrane transporter yjeM HVZ24_20460 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) HVZ24_20465 ENOG4105E33 succinate dehydrogenase HVZ24_20480 ENOG41066YJ Beta-lactamase HVZ24_20485 ENOG4105QNF Outer membrane lipoprotein HVZ24_20490 ENOG4105KPY Small multidrug resistance protein HVZ24_20495 ENOG4106BSU Entericidin B HVZ24_20500 ENOG4107PEH Entericidin EcnA/B family HVZ24_20510 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein HVZ24_20515 ENOG4105MTB Uncharacterized protein YjeJ HVZ24_20520 ENOG4108ZVF (LipO)protein HVZ24_20535 ENOG4105DVH amino acid HVZ24_20540 ENOG4108YH1 overproduction of this protein in Escherichia coli inhibits the F plasmid-mediated exclusion of bacteriophage T7 HVZ24_20545 ENOG4108IJ0 Aspartate ammonia-lyase HVZ24_20550 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter HVZ24_20560 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) HVZ24_20565 ENOG4108SIC Transcriptional regulator HVZ24_20575 ENOG4108M3R transcriptional activator CadC HVZ24_20580 ENOG4105D5Q Arginine ornithine antiporter HVZ24_20585 ENOG4105CXN decarboxylase HVZ24_20590 ENOG4105DUX Transporter HVZ24_20595 ENOG4105CRK lysyL-tRNA synthetase HVZ24_20610 ENOG410830R acetyltransferase HVZ24_20615 ENOG4105VR1 Pfam:DUF1271 HVZ24_20620 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism HVZ24_20625 ENOG4108MRH transcriptional regulatory protein HVZ24_20630 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter HVZ24_20635 ENOG4107GFK fumarate HVZ24_20640 ENOG4108R5S membrane HVZ24_20645 ENOG4105CT4 transporter HVZ24_20650 ENOG4105F8D glycoside hydrolase family 4 HVZ24_20655 ENOG4108K2B transcriptional regulator HVZ24_20660 ENOG4105CXN decarboxylase HVZ24_20665 ENOG4106ZGR Transcriptional regulator HVZ24_20670 ENOG4105D5Q Arginine ornithine antiporter HVZ24_20675 ENOG4105DIJ Phosphoethanolamine transferase HVZ24_20680 ENOG4105XJC Two component transcriptional regulator (Winged helix family HVZ24_20685 ENOG4105ECM Sensor protein basS pmrB HVZ24_20695 ENOG4105CSH Transporter HVZ24_20700 ENOG4108YIV HVZ24_20705 ENOG4108F5E vimentin HVZ24_20710 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA HVZ24_20715 ENOG4108SQ4 Glyoxalase Bleomycin resistance protein (Dioxygenase HVZ24_20720 ENOG4105D5T phosphonate abc transporter HVZ24_20725 ENOG4105EHI Phosphonate ABC transporter, periplasmic HVZ24_20735 ENOG4107RJJ Transcriptional regulator HVZ24_20740 ENOG4105KQZ Phosphonate C-P lyase system protein PhnG HVZ24_20745 ENOG4105KZ6 phosphonate C-P lyase system protein PhnH HVZ24_20750 ENOG4105EKV Phosphonate metabolism protein HVZ24_20755 ENOG4105FT8 Phosphonate metabolism HVZ24_20760 ENOG4105ENV phosphonate C-P lyase system protein PhnK HVZ24_20765 ENOG4105HRV phosphonate c-p lyase system protein phnl HVZ24_20770 ENOG4105FD8 phosphonate metabolism protein PhnM HVZ24_20775 ENOG4105MFQ Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP) (By similarity) HVZ24_20780 ENOG410849A acetyltransferase, (GNAT) family HVZ24_20785 ENOG4107SA6 carbon-phosphorus lyase complex accessory protein HVZ24_20795 ENOG4108YZG isomerase HVZ24_20800 ENOG4105NYY transcriptional regulator, RpiR HVZ24_20805 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator HVZ24_20810 ENOG4105C2J ABC transporter HVZ24_20815 ENOG4105CNN ABC, transporter HVZ24_20820 ENOG4105UP7 3-epimerase HVZ24_20825 ENOG4107TFG D-allose kinase HVZ24_20830 ENOG4105EUZ Beta-lactamase domain protein HVZ24_20835 ENOG4106833 HVZ24_20840 ENOG4105J12 Multidrug resistance protein mdtN HVZ24_20845 ENOG4108MI0 Resistance protein HVZ24_20850 ENOG4105ETP RND efflux system, outer membrane lipoprotein HVZ24_20860 ENOG41082ND Uncharacterized protein yjcO HVZ24_20865 ENOG4105CK2 sodium dicarboxylate symporter HVZ24_20870 ENOG4108W0S formate-dependent nitrite reductase complex HVZ24_20880 ENOG4108QKW cytochrome c-type biogenesis protein HVZ24_20885 ENOG4105DVI reductase, NrfD HVZ24_20890 ENOG4105D3S 4Fe-4S Ferredoxin, iron-sulfur binding domain protein HVZ24_20895 ENOG4105JJ8 Cytochrome c nitrite reductase, pentaheme subunit HVZ24_20905 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) HVZ24_20910 ENOG41062QD Membrane HVZ24_20925 ENOG4105EEQ Na H antiporter HVZ24_20930 ENOG4105C7N Xanthine uracil vitamin C permease HVZ24_20935 ENOG4108Z4X TRANSCRIPTIONal HVZ24_20940 ENOG4108W3Q Transcriptional regulator HVZ24_20945 ENOG4108M8H domain protein HVZ24_20950 ENOG4105PMV Membrane HVZ24_20955 ENOG4108UUM single-stranded DNA-binding protein HVZ24_20960 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) HVZ24_20965 ENOG4105MSB protein, conserved in bacteria HVZ24_20970 ENOG4108YXI Secondary thiamine-phosphate synthase enzyme HVZ24_20975 ENOG4105F0S class B acid phosphatase HVZ24_20985 ENOG4105CGF Aromatic amino acid aminotransferase HVZ24_20990 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) HVZ24_20995 ENOG4105CDU Replicative dna helicase HVZ24_21000 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein HVZ24_21005 ENOG4105P4Z Phage shock protein G HVZ24_21010 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) HVZ24_21020 ENOG4105MYN Zinc uptake regulation protein HVZ24_21025 ENOG4105VDW Csbd family HVZ24_21030 ENOG4107R73 Mate efflux family protein HVZ24_21040 ENOG41080IJ Diacylglycerol kinase HVZ24_21055 ENOG4105VEI Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4- hydroxybenzoate (4HB) for the ubiquinone pathway (By similarity) HVZ24_21065 ENOG4107W52 maltose operon periplasmic protein HVZ24_21070 ENOG4108KDD Involved in the transport of maltose and maltodextrins (By similarity) HVZ24_21075 ENOG4108IJ9 (ABC) transporter HVZ24_21080 ENOG4107FKK extracellular solute-binding protein family 1 HVZ24_21085 ENOG4105D56 permease protein HVZ24_21090 ENOG4105EG2 ABC transporter, permease HVZ24_21095 ENOG4107QNK )-transporter HVZ24_21115 ENOG4105E3R (LipO)protein HVZ24_21120 ENOG4108Q9C Periplasmic Protein HVZ24_21125 ENOG4108MDC (LipO)protein HVZ24_21135 ENOG4107QP8 phosphohexose isomerase HVZ24_21140 ENOG4105CFH Aspartokinase HVZ24_21145 ENOG4108ZR5 Conserved Protein HVZ24_21150 ENOG4105FE9 pseudouridine synthase HVZ24_21160 ENOG4105EAM Na Pi-cotransporter HVZ24_21165 ENOG4105C3R Methionine synthase HVZ24_21170 ENOG41069M3 Transcriptional regulator HVZ24_21180 ENOG4105VS7 Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation (By similarity) HVZ24_21185 ENOG4108I9X Isocitrate lyase HVZ24_21190 ENOG4107QP3 malate synthase g HVZ24_21195 ENOG4105CVG Homoserine O-transsuccinylase HVZ24_21200 ENOG4105K5X acetyltransferase HVZ24_21205 ENOG41062WK cellular response to acidity HVZ24_21230 ENOG4105DC1 bifunctional purine biosynthesis protein purh HVZ24_21235 ENOG4105C12 Phosphoribosylglycinamide synthetase HVZ24_21240 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family HVZ24_21245 ENOG4105BZU Histidine kinase HVZ24_21250 ENOG4105JBU Binds zinc. Could be an important component of the zinc- balancing mechanism HVZ24_21255 ENOG4108T8B Protein of unknown function (DUF1481) HVZ24_21265 ENOG4105R2J Conserved Protein HVZ24_21300 ENOG4105D06 uba thif-type nad fad binding protein HVZ24_21305 ENOG4105WHD thiamine biosynthesis protein ThiS HVZ24_21310 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) HVZ24_21315 ENOG4105D41 biosynthesis protein thiH HVZ24_21320 ENOG410645W Thiamin biosynthesis protein ThiH HVZ24_21355 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) HVZ24_21360 ENOG4105PM1 preprotein translocase subunit SecE HVZ24_21395 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase HVZ24_21400 ENOG4105D4A Cell wall formation (By similarity) HVZ24_21425 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) HVZ24_21430 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) HVZ24_21440 ENOG4108Y73 Membrane HVZ24_21445 ENOG4105EJ2 Transcriptional regulator HVZ24_21455 ENOG4105C5Q Transcriptional regulator HVZ24_21470 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase HVZ24_21475 ENOG4105CWC Acetylornithine deacetylase HVZ24_21480 ENOG4105CCA Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity) HVZ24_21485 ENOG4105DIJ Phosphoethanolamine transferase HVZ24_21490 ENOG4106R3P AraC family transcriptional regulator HVZ24_21495 ENOG4108XCZ PTS System HVZ24_21500 ENOG4108AHH pyruvate formate lyase II activase HVZ24_21510 ENOG4108YRF PTS System HVZ24_21515 ENOG4105DM4 PTS System HVZ24_21520 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) HVZ24_21525 ENOG4107T9Z Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) HVZ24_21530 ENOG4105DCT glycerol dehydrogenase HVZ24_21535 ENOG4108XC3 NADH ubiquinone oxidoreductase HVZ24_21540 ENOG4108Q5Y Membrane HVZ24_21550 ENOG4105SYT Methylenetetrahydrofolate reductase HVZ24_21555 ENOG4105CFH Aspartokinase HVZ24_21560 ENOG4105C28 cystathionine HVZ24_21570 ENOG4107S01 Repressor protein MetJ HVZ24_21580 ENOG4105C25 Primosomal protein n' HVZ24_21585 ENOG4105ETE Transcriptional regulator (LacI family HVZ24_21590 ENOG41063M6 Cell Division Protein HVZ24_21605 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase HVZ24_21620 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) HVZ24_21630 ENOG4105CBT Fructose-1,6-bisphosphatase HVZ24_21635 ENOG4105DP0 ferredoxin-NADP reductase HVZ24_21645 ENOG41065TG regulatoR HVZ24_21650 ENOG4108VTS Membrane HVZ24_21655 ENOG4105EBK exported protein HVZ24_21665 ENOG4105EAF CDP-diacylglycerol pyrophosphatase (EC 3.6.1.26) HVZ24_21670 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein HVZ24_21685 ENOG4105FMW periplasmic HVZ24_21690 ENOG4105E3W Two component transcriptional regulator (Winged helix family HVZ24_21695 ENOG4105E0F Histidine kinase HVZ24_21700 ENOG4108RPX mosc domain containing protein HVZ24_21710 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) HVZ24_21715 ENOG4107YRA Uptake of L-rhamnose across the boundary membrane with the concomitant transport of protons into the cell (symport system) (By similarity) HVZ24_21730 ENOG4105DET Rhamnulokinase HVZ24_21735 ENOG4105DKG l-rhamnose isomerase HVZ24_21750 ENOG41064BA PTS system, fructose-specific, IIA component HVZ24_21755 ENOG4105DM4 PTS System HVZ24_21760 ENOG4105CN9 Peptidase m42 family protein HVZ24_21765 ENOG4106C3V frv operon regulatory protein HVZ24_21770 ENOG4108V87 frv operon regulatory protein HVZ24_21775 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) HVZ24_21785 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein HVZ24_21790 ENOG4108MG3 formate dehydrogenase HVZ24_21795 ENOG4105F46 Necessary for formate dehydrogenase activity (By similarity) HVZ24_21800 ENOG41068KX affects formate dehydrogenase-N HVZ24_21810 ENOG4105SUU thioesterase domain HVZ24_21825 ENOG4105EJU HAD-superfamily hydrolase subfamily IA variant 3 HVZ24_21830 ENOG4105E98 transcriptional regulator DeoR family HVZ24_21835 ENOG4108MGF sugar kinase HVZ24_21845 ENOG4105D2M Aldolase HVZ24_21850 ENOG4107QKS N-acylglucosamine 2-epimerase HVZ24_21855 ENOG4107WI4 Aldose-1-epimerase HVZ24_21860 ENOG4105CJQ hydrolase, family 31 HVZ24_21865 ENOG4105CT4 transporter HVZ24_21870 ENOG4105CT4 transporter HVZ24_21875 ENOG4108KUC Outer membrane channel protein that allows an efficient diffusion of low-molecular-weight solutes such as small sugars and tetraglycine. However, the specific substrate recognized by the OmpL channel is HVZ24_21880 ENOG4105R9B Major Facilitator HVZ24_21885 ENOG4108KHF Resistance protein HVZ24_21890 ENOG4108K85 Transcriptional regulator HVZ24_21895 ENOG4105CI3 gtp-binding protein typa HVZ24_21900 ENOG4105C5F glutamine synthetase HVZ24_21905 ENOG4105CUX Signal transduction histidine kinase HVZ24_21910 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family HVZ24_21915 ENOG4106FIY HVZ24_21920 ENOG4105D4P Coproporphyrinogen iii oxidase HVZ24_21935 ENOG4105C2M dna polymerase I HVZ24_21940 ENOG4106HNH Acyl-transferase HVZ24_21950 ENOG4108Z33 Thiol disulfide Interchange Protein HVZ24_21955 ENOG4105E27 serine threonine protein kinase HVZ24_21960 ENOG4105PC1 Conserved Protein HVZ24_21965 ENOG4105C6R Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) HVZ24_21970 ENOG4105FNP Molybdopterin-guanine dinucleotide biosynthesis protein b HVZ24_22000 ENOG4108RR8 protoporphyrinogen oxidase HVZ24_22005 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) HVZ24_22010 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein HVZ24_22020 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase HVZ24_22025 ENOG4105CHU acetyl-coa acetyltransferase HVZ24_22030 ENOG4108EX3 reductase HVZ24_22035 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) HVZ24_22040 ENOG4105MDZ Transcriptional activator rfaH HVZ24_22045 ENOG4105F8V Hydrolase, tatD family HVZ24_22050 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) HVZ24_22055 ENOG4105X8U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity) HVZ24_22060 ENOG4105WKS Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) HVZ24_22070 ENOG4105JC1 sterol-binding domain protein HVZ24_22080 ENOG4105CGY Dna recombination protein HVZ24_22085 ENOG4108I5U Uridine phosphorylase HVZ24_22090 ENOG4105CDZ Carboxymethylenebutenolidase (EC 3.1.1.45) HVZ24_22095 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) HVZ24_22100 ENOG4105DZ2 Transcriptional regulator HVZ24_22105 ENOG4105EMK carboxylate amino acid amine transporter HVZ24_22110 ENOG4105DQF Hydrolase HVZ24_22115 ENOG4108EUD Lysophospholipase HVZ24_22120 ENOG410829K Lysine exporter protein (Lyse ygga) HVZ24_22125 ENOG4105CCF Lysine exporter protein (Lyse ygga) HVZ24_22130 ENOG4105C9U ATP-dependent DNA helicase RecQ HVZ24_22135 ENOG4105HDD phospholipase HVZ24_22140 ENOG4108VUY thioesterase Superfamily protein HVZ24_22145 ENOG4105FR1 rard protein HVZ24_22150 ENOG4106WR8 Inner membrane protein YigG HVZ24_22155 ENOG4105NRM Membrane HVZ24_22160 ENOG4107QUT magnesium and cobalt transport protein CorA HVZ24_22165 ENOG4108T58 Mg2 transport protein CorA HVZ24_22170 ENOG4105C4R Atp-dependent dna helicase HVZ24_22175 ENOG4105DFC had-superfamily hydrolase, subfamily ia, variant HVZ24_22185 ENOG4105CT0 Protein of unknown function, DUF484 HVZ24_22195 ENOG4105S7Z (LipO)protein HVZ24_22205 ENOG4107T0K Adenylate cyclase HVZ24_22210 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) HVZ24_22215 ENOG41076E6 Uroporphyrinogen-III Synthase HVZ24_22220 ENOG4105ECF c-methyltransferase HVZ24_22225 ENOG410601J HemY protein HVZ24_22230 ENOG4105ENH Sulfatase HVZ24_22235 ENOG4105C4X radical SAM domain protein HVZ24_22260 ENOG4105C85 amino acid HVZ24_22265 ENOG4108UHC Glycosyl transferase, wecb taga cpsf family HVZ24_22270 ENOG4105DAD Could be involved in ECA polysaccharide chain elongation (By similarity) HVZ24_22275 ENOG4105F18 Catalyzes the synthesis of Und-PP-GlcNAc-ManNAcA-Fuc4NAc (Lipid III), the third lipid-linked intermediate involved in ECA synthesis (By similarity) HVZ24_22280 ENOG4105EGZ biosynthesis protein HVZ24_22285 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase HVZ24_22290 ENOG4108WJ1 acetyltransferase HVZ24_22295 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) HVZ24_22300 ENOG4105C1B dTDP-glucose 4-6-dehydratase HVZ24_22305 ENOG4107QQG Dehydrogenase HVZ24_22310 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase HVZ24_22315 ENOG4105SFE lipopolysaccharide biosynthesis protein HVZ24_22320 ENOG4105ESV Glycosyl transferase, family 4 HVZ24_22325 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) HVZ24_22350 ENOG4105C4R Atp-dependent dna helicase HVZ24_22360 ENOG4105KQ5 peptidylprolyl cis-trans isomerase HVZ24_22370 ENOG4105EMY transcriptional regulator HVZ24_22375 ENOG4105C7B Threonine dehydratase HVZ24_22385 ENOG4105CM2 brancheD-chain amino acid aminotransferase HVZ24_22390 ENOG4105P3Y Acetolactate synthase 2 regulatory subunit HVZ24_22410 ENOG4105C0P Mg chelatase subunit ChlI HVZ24_22415 ENOG4108WFC UPF0438 protein yifE HVZ24_22455 ENOG4107EJG GntR family transcriptional regulator HVZ24_22460 ENOG4105C0R drug resistance transporter emrb qaca subfamily HVZ24_22465 ENOG4105ETE Transcriptional regulator (LacI family HVZ24_22470 ENOG4108RVA ribokinase HVZ24_22475 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator HVZ24_22480 ENOG4105CNN ABC, transporter HVZ24_22485 ENOG4105C2J ABC transporter HVZ24_22490 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) HVZ24_22505 ENOG4105EV2 VWA domain protein interacting with AAA ATPase HVZ24_22515 ENOG4108VVK transcriptional Regulator, AsnC HVZ24_22520 ENOG4105QTB Flavodoxin HVZ24_22535 ENOG4105GXX Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit I associates with the membrane and may be involved with cation translocation HVZ24_22585 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) HVZ24_22590 ENOG4107QMV Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity) HVZ24_22595 ENOG4105C8U phosphate abc transporter HVZ24_22600 ENOG4105E2Z phosphate ABC transporter (Permease HVZ24_22605 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) HVZ24_22610 ENOG4108UTW Plays a role in the regulation of phosphate uptake HVZ24_22615 ENOG4105CID antiterminator HVZ24_22620 ENOG4105C5Y PTS System HVZ24_22625 ENOG4105CS2 ec 3.2.1.21 HVZ24_22635 ENOG4105DYC esterase HVZ24_22640 ENOG4107VKM 6-phosphogluconolactonase HVZ24_22645 ENOG4106611 bacteriocin immunity HVZ24_22650 ENOG4106HGK Inner membrane protein yieI HVZ24_22655 ENOG4107UB3 HAD-superfamily hydrolase subfamily IA variant 3 HVZ24_22660 ENOG4105C7N Xanthine uracil vitamin C permease HVZ24_22665 ENOG4108YYH Nadph-dependent fmn reductase HVZ24_22670 ENOG4105E8Q phosphopantetheinyl transferase HVZ24_22675 ENOG4105G2Y Transcriptional regulator HVZ24_22680 ENOG4105CNH Multidrug resistance protein MdtL HVZ24_22685 ENOG4108P6C Tryptophan transporter of low affinity HVZ24_22700 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) HVZ24_22705 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins HVZ24_22720 ENOG4105VG0 50S ribosomal protein l34