locus-tag class description HVZ88_00025 ENOG4105ED4 portal protein HVZ88_00115 ENOG4108US3 tail fiber assembly HVZ88_00120 ENOG4105PTU response to oxidative stress HVZ88_00130 ENOG4108C33 Resolvase HVZ88_00170 ENOG4105ZTC transcriptional activator, Ogr delta HVZ88_00175 ENOG4105C6N Formate acetyltransferase HVZ88_00180 ENOG4105TMB Formate nitrite transporter HVZ88_00185 ENOG4105DDY UPF0142 protein ycaO HVZ88_00190 ENOG4107VMU Membrane HVZ88_00195 ENOG4107QM1 Catalyzes the reversible conversion of 3- phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4- phosphonooxybutanoate to phosphohydroxythreonine (By similarity) HVZ88_00205 ENOG4108K0D peptidase, M48 HVZ88_00215 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) HVZ88_00225 ENOG4108EQH DNA internalization-related competence protein ComEC Rec2 HVZ88_00230 ENOG4105BZ1 (ABC) transporter HVZ88_00235 ENOG4105CHD Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity) HVZ88_00240 ENOG4105T0Z Conserved Protein HVZ88_00255 ENOG4107VR7 transferase activity, transferring phosphorus-containing groups HVZ88_00260 ENOG4107S90 membrAne HVZ88_00265 ENOG4106371 Methyltransferase HVZ88_00275 ENOG4105DAH Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF (By similarity) HVZ88_00280 ENOG4105DUC Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division (By similarity) HVZ88_00285 ENOG4105DIT ErfK YbiS YcfS YnhG family protein HVZ88_00290 ENOG4105EAQ (twin-arginine translocation) pathway signal HVZ88_00295 ENOG4105C5X domain protein HVZ88_00300 ENOG4105CGF Aromatic amino acid aminotransferase HVZ88_00305 ENOG4105FCK Membrane HVZ88_00315 ENOG4107RH7 Nicotinate phosphoribosyltransferase HVZ88_00320 ENOG4105CD8 aminopeptidase N HVZ88_00325 ENOG4105E2Y ABC, transporter HVZ88_00330 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component HVZ88_00340 ENOG4105GVF (ABC) transporter HVZ88_00345 ENOG4108UZX fmn reductase HVZ88_00350 ENOG41071VI Part of the elfADCG-ycbUVF fimbrial operon, which promotes adhesion of bacteria to different abiotic surfaces. ElfA is the major fimbrial subunit produced by this operon HVZ88_00355 ENOG4106JJN Part of the elfADCG-ycbUVF fimbrial operon, which promotes adhesion of bacteria to different abiotic surfaces. Could be required for the biogenesis of the ElfA fimbriae HVZ88_00360 ENOG4105CW0 outer membrane usher protein HVZ88_00365 ENOG4108MDY Fimbrial HVZ88_00370 ENOG4105Q7J Fimbrial HVZ88_00375 ENOG4105MX3 Fimbrial HVZ88_00380 ENOG4106PH7 chaperone HVZ88_00390 ENOG4108T7E Contributes to the efficiency of the cell division process by stabilizing the polymeric form of the cell division protein FtsZ. Acts by promoting interactions between FtsZ protofilaments and suppressing the GTPase activity of FtsZ (By similarity) HVZ88_00395 ENOG4105QVC MOSC domain-containing protein HVZ88_00405 ENOG4105C5H ABC transporter HVZ88_00410 ENOG4105F1S paraquat-inducible protein a HVZ88_00415 ENOG4105DY2 Paraquat-inducible protein b HVZ88_00420 ENOG4108Q2G (LipO)protein HVZ88_00425 ENOG4105WFT During stationary phase, converts 70S ribosomes to an inactive dimeric form (100S ribosomes) (By similarity) HVZ88_00435 ENOG4105DAN ATP-dependent protease HVZ88_00445 ENOG4105UYK outer membrane protein a HVZ88_00455 ENOG4108RZ1 DNA transformation protein HVZ88_00460 ENOG4105EM2 membrane HVZ88_00465 ENOG410901E Membrane HVZ88_00470 ENOG41088T4 Helicase IV HVZ88_00485 ENOG4105K4P CoA-binding domain protein HVZ88_00500 ENOG4105VSY K01512 acylphosphatase EC 3.6.1.7 HVZ88_00505 ENOG4108Z0T Part of a sulfur-relay system (By similarity) HVZ88_00510 ENOG4108MN8 Membrane HVZ88_00520 ENOG4105E3S small subunit HVZ88_00525 ENOG4105DPX Hydrogenase, large subunit HVZ88_00530 ENOG4105X7T Ni Fe-hydrogenase, b-type cytochrome subunit HVZ88_00535 ENOG4108USZ hydrogenase HVZ88_00540 ENOG4108VXY Hydrogenase-1 operon protein HyaE HVZ88_00545 ENOG4105MVP hydrogenase-1 operon protein HyaF HVZ88_00550 ENOG4105C4M (Ubiquinol oxidase) subunit I HVZ88_00555 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii HVZ88_00565 ENOG4105D6F Phosphatase HVZ88_00575 ENOG4108Y9B (LipO)protein HVZ88_00585 ENOG41060EU Cold shock-like protein HVZ88_00590 ENOG4105VEQ Cold shock protein HVZ88_00605 ENOG4106H71 Overexpression increases levels of unsaturated fatty acids and suppresses both the temperature-sensitive fabA6 mutation and cold-sensitive secG null mutation HVZ88_00610 ENOG4105HEE Binding Domain protein HVZ88_00615 ENOG4105BZU Histidine kinase HVZ88_00620 ENOG4108SV3 Tmao reductase system periplasmic protein tort HVZ88_00625 ENOG4106WF9 DNA-binding transcriptional regulator TorR HVZ88_00630 ENOG4105CUW cytochrome C-TYPE protein HVZ88_00635 ENOG4107QY8 reductase HVZ88_00660 ENOG4105D6F Phosphatase HVZ88_00665 ENOG4105XH3 HVZ88_00675 ENOG4105XF5 Escherichia coli IMT2125 genomic chromosome, IMT2125 HVZ88_00680 ENOG4105C2W permease HVZ88_00685 ENOG4107YAQ Catalyzes the reduction of FMN to FMNH2 which is used to reduce pyrimidine by RutA via the Rut pathway (By similarity) HVZ88_00690 ENOG4108RDT NADH dehydrogenase NAD(P)H nitroreductase) HVZ88_00695 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) HVZ88_00705 ENOG4106XMA In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2 (By similarity) HVZ88_00710 ENOG4105EQP Catalyzes the pyrimidine ring opening between N-3 and C- 4 by an unusual flavin hydroperoxide-catalyzed mechanism to yield ureidoacrylate peracid. It cleaves pyrmidine rings directly by adding oxygen atoms, making a toxic ureidoacrylate peracid product which can be spontaneously reduced to ureidoacrylate (By similarity) HVZ88_00715 ENOG4108R86 Transcriptional regulator HVZ88_00720 ENOG4105C26 Dehydrogenase HVZ88_00730 ENOG4105CK7 Sodium proline symporter HVZ88_00740 ENOG410650H (LipO)protein HVZ88_00745 ENOG4105DBE peroxidase HVZ88_00750 ENOG4105D5M phosphate starvation-inducible protein HVZ88_00760 ENOG4105CND Glycosyl transferase, family 2 HVZ88_00765 ENOG4107BJW polysaccharide deacetylase HVZ88_00770 ENOG4108TUY outer membrane protein PgaA HVZ88_00775 ENOG4105BZU Histidine kinase HVZ88_00790 ENOG4108T85 Membrane HVZ88_00805 ENOG4105JPG D-isomer specific 2-hydroxyacid dehydrogenase HVZ88_00810 ENOG4107SSZ Phosphatase HVZ88_00815 ENOG4107XHZ cytoplasmic chaperone TorD family protein HVZ88_00820 ENOG4108UQ5 membrane protein YcdZ HVZ88_00825 ENOG4105P8Q Curli production assembly transport component CsgG HVZ88_00830 ENOG4108WYR Curli production assembly transport component, CsgF HVZ88_00835 ENOG4108XDW curli assembly protein CsgE HVZ88_00840 ENOG41086KC Transcriptional regulator HVZ88_00845 ENOG4108U0V Curli are coiled surface structures that assemble preferentially at growth temperatures below 37 degrees Celsius. Curli can bind to fibronectin. The minor subunit is the nucleation component of curlin monomers HVZ88_00850 ENOG4105G76 Curli are coiled surface structures that assemble preferentially at growth temperatures below 37 degrees Celsius. Curli can bind to fibronectin HVZ88_00855 ENOG4105RK8 Plays a role in the extracellular assembly of CsgA into thin aggregative fimbriae (Tafi) fibers. Assembly may also require CsgE. Tafi are thought to be assembled via an extracellular nucleation-precipitation (ENP) pathway, and possibly also via an intracellular non-CsgC-dependent pathway (By similarity) HVZ88_00865 ENOG4108UVJ appr-1-p processing domain protein HVZ88_00870 ENOG4107RZC phospholipase d HVZ88_00875 ENOG4105EIK Necessary for the succinyl substitution of periplasmic glucans. Could catalyze the transfer of succinyl residues from the cytoplasmic side of the membrane to the nascent glucan backbones on the periplasmic side of the membrane (By similarity) HVZ88_00880 ENOG4105DJ9 glucan biosynthesis protein HVZ88_00885 ENOG4105C3A Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs) (By similarity) HVZ88_00890 ENOG4105NAC (LipO)protein HVZ88_00895 ENOG4108W47 Acidic protein msyB HVZ88_00905 ENOG4105D1S lipid A biosynthesis HVZ88_00910 ENOG4105C72 UPF0176 protein HVZ88_00915 ENOG4108YYC ycei family HVZ88_00920 ENOG4105DS1 cytochrome b561 HVZ88_00925 ENOG4106974 biofilm formation HVZ88_00930 ENOG4105F76 Sarcosine oxidase HVZ88_00935 ENOG4105PVA Biofilm formation regulatory protein BssS HVZ88_00940 ENOG4105MEA DNA damage-inducible protein i HVZ88_00945 ENOG4105EKE dihydroorotase HVZ88_00950 ENOG4105F3T (LipO)protein HVZ88_00955 ENOG4105E9S glutaredoxin 2 HVZ88_00965 ENOG4105D9U N-acetyltransferase HVZ88_00970 ENOG4108YXG UPF0502 protein HVZ88_00975 ENOG4105EP9 oxidoreductase HVZ88_00980 ENOG4105CJR Integral membrane protein (MviN HVZ88_00985 ENOG4105QVD Flagella synthesis protein FlgN HVZ88_00990 ENOG4105M9M anti-sigma28 factor FlgM HVZ88_00995 ENOG4105CKS Flagella basal body P-ring formation protein flgA HVZ88_01000 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) HVZ88_01005 ENOG4108ZC9 flagellar basal-body rod protein flgc HVZ88_01010 ENOG4105W00 Flagellar hook capping protein HVZ88_01015 ENOG4105BZE flagellar hook protein, FlgE HVZ88_01020 ENOG4108KPB Flagellar basal-body rod protein FlgF HVZ88_01025 ENOG4105CGA flagellar basal-body rod protein FlgG HVZ88_01040 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj HVZ88_01045 ENOG4105E1Q flagellar hook-associated protein HVZ88_01050 ENOG4105DTJ flagellar hook-associated protein HVZ88_01055 ENOG4107QQB Ribonuclease E HVZ88_01060 ENOG4105EI2 Pseudouridine synthase HVZ88_01065 ENOG4108UHJ MAF-like protein HVZ88_01070 ENOG4105FCQ metal-binding, possibly nucleic acid-binding protein HVZ88_01090 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase HVZ88_01095 ENOG4105CHR reductase HVZ88_01100 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) HVZ88_01105 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) HVZ88_01110 ENOG4105YAZ 4-amino-4-deoxychorismate lyase HVZ88_01115 ENOG4105HHA aminodeoxychorismate lyase HVZ88_01125 ENOG4107QRG dna polymerase iii HVZ88_01130 ENOG4105F8V Hydrolase, tatD family HVZ88_01135 ENOG4105CI1 PTS System HVZ88_01140 ENOG4105CNM Receptor HVZ88_01145 ENOG4105K59 histidine triad (HIT) protein HVZ88_01150 ENOG41090DQ Lipoprotein HVZ88_01155 ENOG4108WEF Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b) (By similarity) HVZ88_01160 ENOG4108RUM thiamine kinase HVZ88_01165 ENOG4107QPA Cleaves GlcNAc linked beta-1,4 to MurNAc tripeptides (By similarity) HVZ88_01175 ENOG4105CEP NADH dehydrogenase HVZ88_01180 ENOG4107MBR 17 kDa surface antigen HVZ88_01185 ENOG4108IND Tetr family transcriptional regulator HVZ88_01190 ENOG4105RC8 Reduces the permeability of the outer membrane to copper. Seems to be involved in the regulation of biofilm formation. May decrease biofilm formation by repressing cell-cell interaction and cell surface interaction HVZ88_01195 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein HVZ88_01200 ENOG4108JA2 transcriptioN-repair coupling factor HVZ88_01205 ENOG4105IQC Inner membrane protein YcfT HVZ88_01210 ENOG4105D60 lipoprotein releasing system transmembrane protein HVZ88_01215 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) HVZ88_01220 ENOG4105D60 lipoprotein releasing system transmembrane protein HVZ88_01230 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) HVZ88_01245 ENOG4107RUE extracellular solute-binding protein family 1 HVZ88_01250 ENOG4105D38 putrescine abc transporter HVZ88_01260 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HVZ88_01265 ENOG4105D42 Cleaves the N-terminal amino acid of tripeptides (By similarity) HVZ88_01270 ENOG4105EZE Cupin 4 family protein HVZ88_01275 ENOG4105IFJ Histidine kinase HVZ88_01280 ENOG4105XJC Two component transcriptional regulator (Winged helix family HVZ88_01285 ENOG4107QTF adenylosuccinate lyase HVZ88_01305 ENOG4108R99 pseudouridine synthase HVZ88_01310 ENOG4108HMX isocitrate dehydrogenase (NADP) HVZ88_01315 ENOG41066T8 Inhibits RpoS proteolysis by regulating RssB activity, thereby increasing the stability of the sigma stress factor RpoS during magnesium starvation (By similarity) HVZ88_01330 ENOG41064WM Uncharacterized protein YcgX HVZ88_01335 ENOG4108XDN Transcriptional regulator HVZ88_01345 ENOG4105WKE Probably a connector protein for RcsB C regulation of biofilm formation, providing additional signal input into the two- component signaling pathway. Partially antagonizes the activities of YmgA and AriR, proteins that, via the Rcs phosphorelay, promote the synthesis of colanic acid, an exopolysaccharide and matrix component HVZ88_01350 ENOG41077SS Probably a connector protein for RcsB C regulation of biofilm formation, providing additional signal input into the two- component signaling pathway. May serve to stimulate biofilm maturation, probably via the Rcs phosphorelay. Mild overexpression at 16 degrees Celsius increases the production of colanic acid, an exopolysaccharide and matrix component, and reduces adhesive curli fimbriae expression. Both of these effects require RcsB HVZ88_01360 ENOG410738I uncharacterized protein ymgC HVZ88_01370 ENOG4105BZU Histidine kinase HVZ88_01385 ENOG410658X HVZ88_01420 ENOG4107QMS site-determining protein HVZ88_01425 ENOG4105K7U Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) HVZ88_01430 ENOG4105S66 prophage protein HVZ88_01435 ENOG41066UD Inhibits activity of g-type lysozyme, which confers increased lysozyme tolerance to the bacterium HVZ88_01445 ENOG4105FBJ fumarylacetoacetate (faa) hydrolase HVZ88_01460 ENOG4105KT5 UmuD protein HVZ88_01465 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) HVZ88_01470 ENOG410635M Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein (By similarity) HVZ88_01485 ENOG4105ED1 spovr family HVZ88_01495 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) HVZ88_01505 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A HVZ88_01510 ENOG4106S48 Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and or cell division HVZ88_01515 ENOG4108T7K Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Increasing levels of c-di-GMP lead to decreased motility (By similarity) HVZ88_01535 ENOG4105VDH Dihydroxyacetone kinase HVZ88_01540 ENOG4108UTZ Dihydroxyacetone kinase HVZ88_01545 ENOG4105CMT Dihydroxyacetone kinase HVZ88_01550 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family HVZ88_01555 ENOG4105I1J Autotransporter HVZ88_01560 ENOG4105C3G gtp-binding protein HVZ88_01570 ENOG4105MGX transcription activated by CRP (cyclic AMP receptor protein), a global transcription factor involved in regulation of metabolism in enteric bacteria HVZ88_01575 ENOG4105CHH sulfate transporter HVZ88_01580 ENOG4105C5T Phosphoribosyl pyrophosphate synthase HVZ88_01595 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) HVZ88_01605 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) HVZ88_01610 ENOG4108YY7 Invasion gene expression up-regulator SirB HVZ88_01615 ENOG41063JG Transcriptional regulator HVZ88_01640 ENOG4105EWV Sodium calcium exchanger membrane region HVZ88_01645 ENOG4105WS7 Cation transport regulator HVZ88_01650 ENOG4108NH8 Cation transport protein HVZ88_01655 ENOG41090EX DsrE family HVZ88_01660 ENOG4105ID0 Putative invasin HVZ88_01665 ENOG4105WH1 Two component transcriptional regulator luxr family HVZ88_01670 ENOG4105BZU Histidine kinase HVZ88_01675 ENOG4105DQQ Major facilitator superfamily MFS_1 HVZ88_01680 ENOG4105CRU nitrate reductase, alpha subunit HVZ88_01685 ENOG4108IUE nitrate reductase beta subunit HVZ88_01690 ENOG4105R3A Nitrate reductase HVZ88_01695 ENOG41076YT nitrate reductase, gamma subunit HVZ88_01730 ENOG4105CIY formyltetrahydrofolate deformylase HVZ88_01735 ENOG4105K5B UPF0225 protein HVZ88_01740 ENOG4105D78 K07001 NTE family protein HVZ88_01745 ENOG4105I93 response regulator HVZ88_01750 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase HVZ88_01755 ENOG4108SAU DNA-binding protein H-ns HVZ88_01760 ENOG4107104 thymidine kinase HVZ88_01770 ENOG4105C0A alcohol dehydrogenase HVZ88_01775 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein HVZ88_01780 ENOG4108J59 Extracellular solute-binding protein, family 5 HVZ88_01785 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HVZ88_01790 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HVZ88_01795 ENOG4105C3U ABC transporter HVZ88_01800 ENOG4108JQ7 (ABC) transporter HVZ88_01820 ENOG4107SVH Potassium channel protein HVZ88_01825 ENOG4105K9H YciI-like protein HVZ88_01830 ENOG410822N TonB family HVZ88_01835 ENOG4105NAU thioesterase Superfamily protein HVZ88_01845 ENOG4108S3I UPF0259 membrane protein HVZ88_01855 ENOG4105EIF outer membrane protein W HVZ88_01860 ENOG4108I1J Integrase HVZ88_01875 ENOG4106G8A Qin prophage HVZ88_01915 ENOG4105JBR DNA replication protein HVZ88_01985 ENOG4108MXB Protein of unknown function (DUF968) HVZ88_01990 ENOG4105KSK (crossover) junction endodeoxyribonuclease HVZ88_02065 ENOG4105FKG DNA packaging protein HVZ88_02070 ENOG4105UZW Tail fiber assembly protein HVZ88_02075 ENOG4107DE1 head-to-tail joining protein HVZ88_02085 ENOG4105F7J membrane-bound serine protease HVZ88_02095 ENOG4105IM0 capsid protein HVZ88_02140 ENOG4105R8V Transcriptional regulator HVZ88_02150 ENOG4108WTW DNA transposition protein HVZ88_02270 ENOG4105QIB mu-like prophage Flumu protein gp29 HVZ88_02295 ENOG4105EFV Major head subunit HVZ88_02375 ENOG4108X9F tail fiber protein HVZ88_02375 ENOG4108X9F tail fiber protein HVZ88_02380 ENOG4105UZW Tail fiber assembly protein HVZ88_02385 ENOG4108X9F tail fiber protein HVZ88_02450 ENOG4108N8X transition metal ion binding HVZ88_02455 ENOG4108Z9Z response to DNA damage stimulus HVZ88_02475 ENOG4105DK0 Indole-3-glycerol phosphate synthase HVZ88_02480 ENOG4108EFP Anthranilate synthase component II HVZ88_02485 ENOG4105CRQ synthase (Component I) HVZ88_02495 ENOG4105DB7 PHP domain protein HVZ88_02500 ENOG4107RTD sua5 ycio yrdc ywlc family protein HVZ88_02505 ENOG4105EG3 transmembrane signal peptide protein HVZ88_02510 ENOG4105FE9 pseudouridine synthase HVZ88_02515 ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase HVZ88_02520 ENOG4105UBK short-chain dehydrogenase reductase HVZ88_02525 ENOG4105ERU peptidase HVZ88_02530 ENOG4105RKX Protein of unknown function (DUF2498) HVZ88_02535 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) HVZ88_02540 ENOG4107R11 Transcriptional regulator HVZ88_02560 ENOG4107QM5 aconitate hydratase HVZ88_02570 ENOG4105EYK Phosphatidylglycerophosphatase B HVZ88_02575 ENOG4105Q4A inner membrane protein yciS HVZ88_02580 ENOG4105CFV Tetratricopeptide repeat protein HVZ88_02585 ENOG4106EG9 Catalyzes the decarboxylation of orotidine 5'- monophosphate (OMP) to uridine 5'-monophosphate (UMP) (By similarity) HVZ88_02590 ENOG4108ZJT translation initiation factor, Sui1 HVZ88_02600 ENOG4105N2W Transcriptional regulator HVZ88_02605 ENOG410643D UPF0509 protein HVZ88_02610 ENOG4105BZU Histidine kinase HVZ88_02625 ENOG4105Q4T oxidoreductase HVZ88_02630 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH HVZ88_02635 ENOG4105WDY DNA (cytosine-5-)-methyltransferase HVZ88_02640 ENOG4108JQ2 peptide transport system atp-binding protein HVZ88_02645 ENOG4108JQ3 Peptide ABC transporter ATP-binding protein HVZ88_02650 ENOG4108EU3 peptide transport system, permease HVZ88_02655 ENOG4108I5W peptide transport system, permease protein HVZ88_02660 ENOG4108HIY periplasmic HVZ88_02665 ENOG4105N0E Protein of unknown function (DUF2543) HVZ88_02670 ENOG4105CUB amino acid HVZ88_02680 ENOG4105CFQ glutamine synthetase HVZ88_02685 ENOG4108Z86 Glutamine amidotransferase HVZ88_02690 ENOG4107VRI Transcriptional regulator HVZ88_02695 ENOG4105C26 Dehydrogenase HVZ88_02700 ENOG4105CJP fad dependent oxidoreductase HVZ88_02705 ENOG4108JPW Aminotransferase HVZ88_02710 ENOG4105E51 psp operon transcriptional activator HVZ88_02715 ENOG41087YS Phage shock protein A HVZ88_02720 ENOG4105YYT phage shock protein B HVZ88_02725 ENOG4105FM1 phage shock protein C HVZ88_02730 ENOG4105NNG Peripheral inner membrane phage-shock protein HVZ88_02735 ENOG4105K8Z Phage shock protein HVZ88_02740 ENOG4107QW3 Sucrose phosphorylase HVZ88_02745 ENOG4105WEM extracellular solute-binding protein HVZ88_02750 ENOG4105HS6 binding-protein-dependent transport systems inner membrane Component HVZ88_02755 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component HVZ88_02760 ENOG4107RRD Dehydrogenase HVZ88_02765 ENOG4107TYA transient receptor potential locus HVZ88_02770 ENOG4105CK5 oxidoreductase HVZ88_02775 ENOG4105C71 hydrolase family 65, central catalytic HVZ88_02780 ENOG4107URF beta-phospho-glucomutase HVZ88_02785 ENOG4108IJ9 (ABC) transporter HVZ88_02790 ENOG4107EFV Outer membrane protein G HVZ88_02795 ENOG4105FKQ transcriptional regulator HVZ88_02800 ENOG4105CM6 amino acid regulated cytosolic protein HVZ88_02810 ENOG4108JU8 Transcriptional regulator HVZ88_02815 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) HVZ88_02820 ENOG4107S8C mandelate racemase muconate lactonizing HVZ88_02825 ENOG4105KXI murein peptide amidase A HVZ88_02840 ENOG4105ENX hydrolase HVZ88_02845 ENOG4105EQ2 LysR family Transcriptional regulator HVZ88_02850 ENOG4107QSI ABC, transporter HVZ88_02855 ENOG4105D64 Mechanosensitive ion channel HVZ88_02860 ENOG4105S5I Membrane HVZ88_02865 ENOG4105Q9Y Universal stress protein HVZ88_02870 ENOG4105DS0 Transcriptional regulator, Crp Fnr family HVZ88_02875 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) HVZ88_02880 ENOG4105CFC Transporter HVZ88_02885 ENOG4107RT5 aminobenzoyl-glutamate utilization protein B HVZ88_02890 ENOG4105CH2 amidohydrolase HVZ88_02895 ENOG4106KR7 LysR family Transcriptional regulator HVZ88_02900 ENOG4108DG9 Smr protein MutS2 HVZ88_02905 ENOG4105BZU Histidine kinase HVZ88_02915 ENOG4105C1J atp-dependent rna helicase HVZ88_02925 ENOG4108RW8 Universal stress protein F HVZ88_02930 ENOG4105FCK Membrane HVZ88_02935 ENOG4105D95 Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity) HVZ88_02940 ENOG4105IKK cytoplasmic protein HVZ88_02945 ENOG41090X5 Heat shock protein hslJ HVZ88_02950 ENOG4105C5I Dehydrogenase HVZ88_02955 ENOG4107H52 Dicarboxylate transport HVZ88_02960 ENOG410689M (LipO)protein HVZ88_02965 ENOG4105WXT Conserved Protein HVZ88_02970 ENOG4108WFR AraC Family Transcriptional Regulator HVZ88_02975 ENOG4105C26 Dehydrogenase HVZ88_02985 ENOG4105DXM phenylacetic acid degradation protein HVZ88_02990 ENOG4105CRS phenylacetate-CoA oxygenase PaaG subunit HVZ88_02995 ENOG4105N76 Phenylacetate-CoA oxygenase, subunit HVZ88_03000 ENOG4105D9S phenylacetate-CoA oxygenase PaaI subunit HVZ88_03005 ENOG4108ZA2 phenylacetate-CoA oxygenase PaaJ subunit HVZ88_03010 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) HVZ88_03015 ENOG4105E39 Enoyl-CoA hydratase HVZ88_03020 ENOG4108UKI Enoyl-CoA hydratase HVZ88_03025 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase HVZ88_03030 ENOG4108ZJI phenylacetic acid degradation protein HVZ88_03035 ENOG4105CHU acetyl-coa acetyltransferase HVZ88_03040 ENOG4105DZS Phenylacetate-CoA ligase HVZ88_03045 ENOG4105V9J phenylacetic acid degradation operon negative regulatory protein HVZ88_03050 ENOG4108Z0R Transferase HVZ88_03060 ENOG4107EF2 surface-exposed virulence protein HVZ88_03065 ENOG4107S5I aldo keto reductase HVZ88_03075 ENOG4108UMZ Cdp-alcohol phosphatidyltransferase HVZ88_03080 ENOG4108HPI phosphatidate Cytidylyltransferase HVZ88_03085 ENOG4105E8V Alpha Beta Hydrolase Fold protein HVZ88_03100 ENOG4105CQ7 ATP-dependent helicase HVZ88_03105 ENOG4107DB1 DUF218 domain HVZ88_03110 ENOG4105C26 Dehydrogenase HVZ88_03125 ENOG4105CPW cytochrome b561 HVZ88_03130 ENOG4105UPP uncharacterized protein ydcA HVZ88_03135 ENOG4107NK6 Hok/gef family HVZ88_03140 ENOG4105C8Q Methyl-accepting chemotaxis HVZ88_03145 ENOG4105DDW LysR family Transcriptional regulator HVZ88_03150 ENOG4105E32 cytoplasmic protein HVZ88_03155 ENOG4105DJ9 glucan biosynthesis protein HVZ88_03160 ENOG4105Z2P Protein of unknown function (DUF465) HVZ88_03165 ENOG4108Z9I -acetyltransferase HVZ88_03170 ENOG4107WE3 acetyltransferase YdcK HVZ88_03175 ENOG4108NKP c4-dicarboxylate transporter malic acid transport protein HVZ88_03180 ENOG41088CC tellurite resistance protein tehB HVZ88_03185 ENOG4108KKZ (LipO)protein HVZ88_03195 ENOG4105D7V transposase HVZ88_03200 ENOG4105DKK Benzoate HVZ88_03205 ENOG4108JCI Transcriptional regulator HVZ88_03210 ENOG4105CFP Peptidase U32 HVZ88_03215 ENOG4105RR0 Protein of unknown function (DUF2554) HVZ88_03225 ENOG4105PF0 Antitoxin component of a toxin-antitoxin (TA) module. Functions as an mRNA interferase antitoxin HVZ88_03230 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HVZ88_03235 ENOG4107TYH extracellular solute-binding protein family 1 HVZ88_03240 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HVZ88_03245 ENOG4105D81 ABC transporter, permease HVZ88_03250 ENOG4105NRK Binding-protein-dependent transport systems, inner membrane component HVZ88_03265 ENOG410654E Membrane HVZ88_03270 ENOG4105R71 cytoplasmic protein HVZ88_03275 ENOG4108T9Y Inner membrane protein ydcZ HVZ88_03280 ENOG4108Z7F N-acetyltransferase HVZ88_03285 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein HVZ88_03290 ENOG4108WYP Transcriptional regulator HVZ88_03295 ENOG4105CHB tonB-dependent Receptor HVZ88_03300 ENOG4108NS2 receptor HVZ88_03305 ENOG4105C85 amino acid HVZ88_03310 ENOG4108N27 Glutathione S-transferase HVZ88_03345 ENOG410600T transposase HVZ88_03350 ENOG4105KZK Tautomerase pptA HVZ88_03355 ENOG4108MEJ flavin reductase domain protein HVZ88_03360 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase HVZ88_03365 ENOG4105JAB phenazine biosynthesis protein, phzf family HVZ88_03370 ENOG4105D0D Nitrate reductase 2, gamma subunit HVZ88_03375 ENOG4108NZN Respiratory nitrate reductase 2 delta chain HVZ88_03380 ENOG4108IUE nitrate reductase beta subunit HVZ88_03385 ENOG4105CRU nitrate reductase, alpha subunit HVZ88_03390 ENOG4107QND Nitrite extrusion protein HVZ88_03405 ENOG4105RPH Inner membrane protein YddG HVZ88_03415 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein HVZ88_03420 ENOG4108MG3 formate dehydrogenase HVZ88_03425 ENOG41084S7 Plasmid maintenance system antidote protein HVZ88_03430 ENOG4105DQ4 alcohol dehydrogenase HVZ88_03440 ENOG4107AV5 Although this protein associates with the 30S subunit of the ribosome it is not considered to be a bona fide ribosomal protein HVZ88_03445 ENOG4105TPS biofilm-dependent modulation protein HVZ88_03450 ENOG4108Z9K Osmotically inducible protein HVZ88_03455 ENOG4107H6U ABC transporter HVZ88_03460 ENOG4105C3U ABC transporter HVZ88_03465 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HVZ88_03470 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HVZ88_03475 ENOG4105DEF Extracellular solute-binding protein, family 5 HVZ88_03480 ENOG4108UQS dipeptidase HVZ88_03485 ENOG4105BZU Histidine kinase HVZ88_03490 ENOG4105BZU Histidine kinase HVZ88_03500 ENOG4105F32 YngK protein HVZ88_03505 ENOG4105E5D amino acid HVZ88_03510 ENOG4105CVK Glutamate decarboxylase HVZ88_03515 ENOG4107RAN Peptidase, M16 HVZ88_03520 ENOG4105PE1 Receptor HVZ88_03525 ENOG4105CQ0 ABC transporter HVZ88_03535 ENOG4105C4X radical SAM domain protein HVZ88_03540 ENOG4105ENH Sulfatase HVZ88_03555 ENOG4107QKC Oxidoreductase alpha (molybdopterin) subunit HVZ88_03560 ENOG4106PIH fimbrial-like protein ydeQ HVZ88_03565 ENOG4106318 fimbrial-like protein YdeR HVZ88_03570 ENOG4108WDE Fimbrial protein HVZ88_03600 ENOG4105K4U addiction module toxin, RelE StbE family HVZ88_03620 ENOG4108MXB Protein of unknown function (DUF968) HVZ88_03625 ENOG4105HGD Antitermination protein HVZ88_03640 ENOG4105VEQ Cold shock protein HVZ88_03645 ENOG4105QFS Lysis protein S homolog from lambdoid prophage HVZ88_03660 ENOG4108YV9 Protein of unknown function (DUF2514) HVZ88_03665 ENOG4105VEQ Cold shock protein HVZ88_03680 ENOG4106IAW HVZ88_03685 ENOG4106H71 Overexpression increases levels of unsaturated fatty acids and suppresses both the temperature-sensitive fabA6 mutation and cold-sensitive secG null mutation HVZ88_03690 ENOG41064WM Uncharacterized protein YcgX HVZ88_03695 ENOG4106YSC HVZ88_03700 ENOG4105FKG DNA packaging protein HVZ88_03710 ENOG4105UZW Tail fiber assembly protein HVZ88_03715 ENOG4105MN3 Resolvase HVZ88_03720 ENOG4105W3V DNA-binding, transcriptional regulator HVZ88_03735 ENOG4105DEI Mannitol dehydrogenase HVZ88_03740 ENOG41061EV selenium-binding protein YdfZ HVZ88_03745 ENOG4107XBN GntR Family Transcriptional Regulator HVZ88_03750 ENOG4105EMU Dehydrogenase HVZ88_03755 ENOG4105DGW oligopeptidase A HVZ88_03760 ENOG4108WTK competence damage-inducible protein HVZ88_03765 ENOG4108YDI single-species biofilm formation on inanimate substrate HVZ88_03770 ENOG4105FSR swimming returnes to normal when residues 206-207 are both mutated to Ala. Overexpression also leads to a reduction in flagellar abundance and a 20-fold increase in c-di- GMP levels in vivo. Required for aminoglycoside-mediated induction of biofilm formation, it also plays a lesser role in biofilm production in response to other classes of translation inhibitors. The c-di-GMP produced by this enzyme up-regulates poly-GlcNAc production as well as the biofilm synthesis protein PgaD, although c-di-GMP is probably not the main inducing principle. Cyclic-di- GMP is a second messenger which controls cell surface-associated traits in bacteria HVZ88_03780 ENOG4105E5W Transporter HVZ88_03785 ENOG4108594 Permease of the drug metabolite transporter HVZ88_03790 ENOG4106DNR multiple antibiotic resistance protein HVZ88_03795 ENOG4108XW0 May be a transcriptional activator of genes involved in the multiple antibiotic resistance (Mar) phenotype. It can also activate genes such as sodA, zwf and micF HVZ88_03800 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes HVZ88_03820 ENOG4105EGI Transcriptional regulator HVZ88_03825 ENOG4105C26 Dehydrogenase HVZ88_03830 ENOG4105CSV Glutaminase HVZ88_03835 ENOG4105M0C cytoplasmic protein HVZ88_03840 ENOG4105BZU Histidine kinase HVZ88_03850 ENOG4105FFC UPF0187 protein HVZ88_03855 ENOG4107R6G Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate (By similarity) HVZ88_03860 ENOG4105K34 Involved in the degradation of phospho-AI-2, thereby terminating induction of the lsr operon and closing the AI-2 signaling cycle. Catalyzes the cleavage of phosphorylated 4,5- dihydroxy-2,3-pentanedione (P-DPD) to 2-phosphoglycolic acid (PG) and another three-carbon compound HVZ88_03870 ENOG4105D4B ABC, transporter HVZ88_03880 ENOG41071MT Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane HVZ88_03885 ENOG4105C2J ABC transporter HVZ88_03905 ENOG41061P8 Persistence to inhibition of murein or DNA biosynthesis regulatory protein HVZ88_03910 ENOG4105CAF HipA N-terminal domain protein HVZ88_03960 ENOG4106G8A Qin prophage HVZ88_03975 ENOG4107R08 Integrase HVZ88_03985 ENOG4105CPQ Dehydrogenase HVZ88_03990 ENOG4105CXK mandelate racemase muconate lactonizing HVZ88_04005 ENOG4108MK9 spermidine N(1)-acetyltransferase HVZ88_04010 ENOG4105D69 UPF0257 lipoprotein ynfC HVZ88_04015 ENOG4105KBG Protein of unknown function (DUF1161) HVZ88_04020 ENOG4107QY8 reductase HVZ88_04025 ENOG4105C3J Cysteine desulfurase HVZ88_04030 ENOG4105QAX Iron-sulfur HVZ88_04035 ENOG4107KGK dmso reductase anchor subunit HVZ88_04040 ENOG4108NEM leader-binding protein dmsD HVZ88_04050 ENOG4105EWW Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) HVZ88_04055 ENOG4105DAG ROK family HVZ88_04060 ENOG4106NZI LysR family Transcriptional regulator HVZ88_04065 ENOG4105D94 Major Facilitator Superfamily HVZ88_04080 ENOG4105CVW peptidase s1 and s6 chymotrypsin hap HVZ88_04095 ENOG4105DSF transport protein HVZ88_04100 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) HVZ88_04105 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) HVZ88_04110 ENOG4105C5D exported protein HVZ88_04115 ENOG4105D5Q Arginine ornithine antiporter HVZ88_04125 ENOG4105RA2 Membrane HVZ88_04130 ENOG4107EXC regulatoR HVZ88_04135 ENOG4105JJR Histidine kinase HVZ88_04145 ENOG4105C9Q fumarate hydratase class II HVZ88_04150 ENOG4107GFK fumarate HVZ88_04155 ENOG4105EIP mannose-6-phosphate isomerase HVZ88_04160 ENOG4106J39 exported protein HVZ88_04165 ENOG4108QNI outer membrane porin protein HVZ88_04170 ENOG4105CT4 transporter HVZ88_04175 ENOG4105CNT hydrolase family 2 HVZ88_04180 ENOG4105XEA Tetr family transcriptional regulator HVZ88_04185 ENOG4107ZQV short-chain dehydrogenase reductase HVZ88_04190 ENOG4107P2S Transcriptional regulator HVZ88_04195 ENOG4105CI1 PTS System HVZ88_04200 ENOG4105C87 Aminotransferase class I and II HVZ88_04210 ENOG4105D9R oxidoreductase HVZ88_04215 ENOG4106C6R beta-lactam resistance protein HVZ88_04220 ENOG4105QZ5 OriC-binding nucleoid-associated protein HVZ88_04225 ENOG4105M9B inner membrane protein ydgK HVZ88_04250 ENOG4108UQQ Electron transport complex HVZ88_04260 ENOG4105CSM endonuclease III HVZ88_04265 ENOG4105DUX Transporter HVZ88_04270 ENOG4108K3A Glutathione S-transferase HVZ88_04275 ENOG4107XGF functions in a salvage pathway. Uses pyridoxamine (By similarity) HVZ88_04290 ENOG410642K Lysozyme inhibitor HVZ88_04300 ENOG4108XTF Outer Membrane Lipoprotein HVZ88_04315 ENOG4105Y49 secretion protein, HlyD family HVZ88_04320 ENOG4105DSW Fusaric acid resistance protein HVZ88_04325 ENOG4108Z7T Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) HVZ88_04330 ENOG4107RGM aldo keto reductase HVZ88_04335 ENOG4105XZD Fe-S protein HVZ88_04340 ENOG4108WUH Transcriptional regulator, TetR family HVZ88_04345 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HVZ88_04350 ENOG4108UYE Lactoylglutathione lyase HVZ88_04355 ENOG4105DH5 Responsible for the end-turnover of tRNA specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis (By similarity) HVZ88_04360 ENOG4107QRT dEAD DEAH box helicase HVZ88_04365 ENOG4105M2J Glutaredoxin HVZ88_04370 ENOG4105K4H Nlp p60 protein HVZ88_04375 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) HVZ88_04380 ENOG4105F27 Major Facilitator HVZ88_04395 ENOG4105F52 Transcriptional regulator HVZ88_04400 ENOG4105CZQ inner membrane transport protein YdhC HVZ88_04405 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase HVZ88_04410 ENOG4108R6K riboflavin synthase, subunit alpha HVZ88_04415 ENOG4107QI1 Mate efflux family protein HVZ88_04435 ENOG4105N0V mono-oxygenase ydhR HVZ88_04440 ENOG4108KTU conserved protein with FAD NAD(P)-binding domain HVZ88_04445 ENOG4108Y7C Conserved Protein HVZ88_04450 ENOG4108NWD Cytochrome HVZ88_04455 ENOG4108393 oxidoreductase Fe-S subunit HVZ88_04460 ENOG4105JVW HVZ88_04465 ENOG4105WE2 aldehyde ferredoxin oxidoreductase HVZ88_04470 ENOG4108PU5 4fe-4S ferredoxin, iron-sulfur binding domain protein HVZ88_04475 ENOG4105RFR Protein of unknown function (DUF2767) HVZ88_04480 ENOG4105CA9 Pyruvate kinase HVZ88_04485 ENOG4105KMX major outer membrane lipoprotein HVZ88_04490 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein HVZ88_04500 ENOG4105C9B Cysteine desulfurase HVZ88_04505 ENOG4105JRK feS assembly protein SufD HVZ88_04510 ENOG4105C3K feS assembly ATPase SufC HVZ88_04515 ENOG4105DIW FeS assembly protein SUFB HVZ88_04520 ENOG4108Z4V iron-sulfur cluster assembly HVZ88_04525 ENOG410671Z uncharacterized protein ydiH HVZ88_04530 ENOG4105KA0 thioesterase Superfamily protein HVZ88_04535 ENOG4105CQB FAD linked oxidase domain protein HVZ88_04540 ENOG4105IPI Membrane HVZ88_04550 ENOG4105SUA Ydil protein HVZ88_04555 ENOG4105EMV Major Facilitator HVZ88_04560 ENOG4105EMV Major Facilitator HVZ88_04575 ENOG4107R0K CoA transferase having broad substrate specificity for short-chain acyl-CoA thioesters with the activity decreasing when the length of the carboxylic acid chain exceeds four carbons (By similarity) HVZ88_04580 ENOG4105C1G acyl-Coa dehydrogenase HVZ88_04585 ENOG4105W4W Transcriptional regulator HVZ88_04590 ENOG4105CV7 Electron transfer flavoprotein HVZ88_04595 ENOG4105C10 Electron transfer flavoprotein HVZ88_04600 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase HVZ88_04605 ENOG41090P5 ferredoxin-like protein HVZ88_04610 ENOG4105CEY Amp-dependent synthetase and ligase HVZ88_04615 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) HVZ88_04625 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) HVZ88_04640 ENOG4108TC0 Diguanylate phosphodiesterase HVZ88_04645 ENOG4108QBX (LipO)protein HVZ88_04655 ENOG4108V06 Glutathione peroxidase HVZ88_04675 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HVZ88_04735 ENOG4105ED4 portal protein HVZ88_04830 ENOG4105UZW Tail fiber assembly protein HVZ88_04840 ENOG4108C33 Resolvase HVZ88_04905 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) HVZ88_04925 ENOG41082NX 50s ribosomal protein l35 HVZ88_04930 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) HVZ88_04950 ENOG4108NE3 Salt-induced outer membrane protein HVZ88_04955 ENOG4105DE4 1-phosphofructokinase HVZ88_04960 ENOG4105P10 Uncharacterized protein ydiZ HVZ88_04970 ENOG4107PN8 YfeABCD locus regulator HVZ88_04975 ENOG4107UW8 HAD-superfamily hydrolase subfamily IA variant 3 HVZ88_04980 ENOG4107K5X Membrane-bound metal-dependent hydrolase HVZ88_04985 ENOG4108ETY sodium dicarboxylate symporter HVZ88_05000 ENOG4105CH6 catalase HVZ88_05005 ENOG410901P UPF0249 protein HVZ88_05010 ENOG4105F8D glycoside hydrolase family 4 HVZ88_05015 ENOG4105EZV Transcriptional regulator HVZ88_05020 ENOG4105VCP PTS System HVZ88_05025 ENOG4105CK1 PTS System HVZ88_05030 ENOG4105VZJ PTS System HVZ88_05035 ENOG4105KKI DNA-binding transcriptional activator OsmE HVZ88_05045 ENOG4105DKD Incises the DNA at the 3' side of a lesion during nucleotide excision repair. Incises the DNA farther away from the lesion than UvrC. Not able to incise the 5' site of a lesion. When a lesion remains because UvrC is not able to induce the 3' incision, Cho incises the DNA. Then UvrC makes the 5' incision. The combined action of Cho and UvrC broadens the substrate range of nucleotide excision repair (By similarity) HVZ88_05055 ENOG4108SPG Periplasmic Protein HVZ88_05065 ENOG4105EY2 Catalyzes the hydrolysis of N(2)-succinylarginine into N(2)-succinylornithine, ammonia and CO(2) (By similarity) HVZ88_05085 ENOG4105CGK Exodeoxyribonuclease III HVZ88_05090 ENOG4108RSN SNARE associated Golgi HVZ88_05095 ENOG4108KCW iron-sulfur cluster binding HVZ88_05100 ENOG4108N5C SNARE associated Golgi protein-related protein HVZ88_05105 ENOG4107ZN8 Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) HVZ88_05110 ENOG4105VNH ABC transporter solute-binding protein HVZ88_05115 ENOG4105CXZ ABC transporter, permease HVZ88_05120 ENOG4108VGW abc transporter atp-binding protein HVZ88_05125 ENOG4107RM6 sulfurtransferase HVZ88_05130 ENOG4108T9J Cdp-alcohol phosphatidyltransferase HVZ88_05135 ENOG4105M6F mutator MutT protein HVZ88_05140 ENOG4105MTM Protein of unknown function (DUF1496) HVZ88_05145 ENOG4105D82 Glutamate dehydrogenase HVZ88_05150 ENOG41065FB inner membrane protein ynji HVZ88_05155 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) HVZ88_05165 ENOG41069NU Nitroreductase HVZ88_05170 ENOG4105D07 Signal peptide peptidase, SppA HVZ88_05175 ENOG4105HDK L-asparaginase HVZ88_05180 ENOG4108RWI nicotinamidase HVZ88_05185 ENOG4108KUU Inner membrane metabolite transport protein ydjE HVZ88_05190 ENOG4105E98 transcriptional regulator DeoR family HVZ88_05195 ENOG4105CPC Aldo Keto reductase HVZ88_05200 ENOG4107UH8 sugar kinase HVZ88_05205 ENOG4105D2N Aldolase HVZ88_05210 ENOG4105CPQ Dehydrogenase HVZ88_05215 ENOG4107TE1 transport protein HVZ88_05225 ENOG4105VUT cytoplasmic protein HVZ88_05235 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase HVZ88_05240 ENOG4105DSB aldose 1-epimerase HVZ88_05245 ENOG4105CV8 reductase HVZ88_05250 ENOG4105GNX MltA-interacting MipA family protein HVZ88_05255 ENOG4105CYN Serine protein kinase HVZ88_05260 ENOG4106AKX UPF0229 protein HVZ88_05265 ENOG4106KTS Inner membrane protein yeaI HVZ88_05270 ENOG4108KHP Diguanylate cyclase HVZ88_05275 ENOG4108KXH Ybak prolyl-tRNA synthetase associated HVZ88_05290 ENOG4105R1U AraC Family Transcriptional Regulator HVZ88_05295 ENOG4105DJ2 Major Facilitator Superfamily HVZ88_05300 ENOG4105K78 MarR family Transcriptional regulator HVZ88_05305 ENOG4105UCG Domain of unknown function (DUF333) HVZ88_05310 ENOG410620I Diguanylate cyclase HVZ88_05315 ENOG4106G4W HVZ88_05325 ENOG4105Y3U Transglycosylase-associated protein HVZ88_05330 ENOG4105YP6 Domain of unknown function (DUF1869) HVZ88_05335 ENOG4108YS1 cytoplasmic protein HVZ88_05345 ENOG4105EJC lysr family transcriptional regulator HVZ88_05350 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) HVZ88_05360 ENOG4105DVW rieske (2Fe-2S) HVZ88_05365 ENOG4105E3J oxidoreductase HVZ88_05370 ENOG4105ZIE Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity) HVZ88_05375 ENOG4105CEY Amp-dependent synthetase and ligase HVZ88_05380 ENOG4105Y4Z Outer Membrane Lipoprotein HVZ88_05385 ENOG41072GX Peptidase M22 Glycoprotease HVZ88_05390 ENOG4105DVT helicase HVZ88_05395 ENOG4105M4H endoribonuclease L-psp HVZ88_05400 ENOG4105V2F Uncharacterized protein yoac HVZ88_05410 ENOG4105CRQ synthase (Component I) HVZ88_05415 ENOG4105P8F nudix hydrolase HVZ88_05420 ENOG4105EJQ L-serine dehydratase HVZ88_05425 ENOG4107XTP (EAL) domain protein HVZ88_05430 ENOG4105EE5 Membrane protein terC HVZ88_05435 ENOG4105DAS pts system HVZ88_05440 ENOG4105ETZ PTS System HVZ88_05445 ENOG4105F3R pts system mannose fructose sorbose family iid HVZ88_05460 ENOG4105DHI Methyltransferase HVZ88_05475 ENOG4105Q3Y exported protein HVZ88_05485 ENOG4105TIK HVZ88_05490 ENOG4105J4Q Transcriptional regulator HVZ88_05495 ENOG4105C0R drug resistance transporter emrb qaca subfamily HVZ88_05505 ENOG4105CN1 protease HVZ88_05515 ENOG4108ZGC gaf domain protein HVZ88_05520 ENOG4105H2K paraquat-inducible protein a HVZ88_05525 ENOG4105DY2 Paraquat-inducible protein b HVZ88_05535 ENOG4105WT8 Protein of unknown function (DUF1480) HVZ88_05540 ENOG4105UVW uncharacterized protein yebW HVZ88_05545 ENOG4108R1E Serine threonine protein phosphatase 1 HVZ88_05550 ENOG4105NKT exported protein HVZ88_05555 ENOG4108PNC copper resistance HVZ88_05560 ENOG4105FXM Copper resistance protein HVZ88_05565 ENOG4105MPK DNA polymerase III subunit theta HVZ88_05570 ENOG4108YGA nitrilase cyanide hydratase and apolipoprotein n-acyltransferase HVZ88_05575 ENOG4105UMD exodeoxyribonuclease X HVZ88_05580 ENOG4105CUG Oligopeptidase b HVZ88_05585 ENOG4108Q2J Inner membrane protein YebE HVZ88_05595 ENOG4105X2V dna damage-inducible protein HVZ88_05600 ENOG4108HH9 Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR HVZ88_05605 ENOG4108UHU Aldolase HVZ88_05610 ENOG4105C01 Dihydroxy-acid dehydratase HVZ88_05615 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase HVZ88_05620 ENOG4106KNT transcriptional regulator HVZ88_05625 ENOG4105CA9 Pyruvate kinase HVZ88_05630 ENOG4105NWR lipid A biosynthesis (Kdo)2-(Lauroyl)-lipid IVA acyltransferase HVZ88_05635 ENOG4105DR5 peptidase HVZ88_05640 ENOG4105NXV High-affinity zinc uptake system protein HVZ88_05650 ENOG4105FAV ABC, transporter HVZ88_05670 ENOG4107S01 Repressor protein MetJ HVZ88_05680 ENOG4105CDY transcriptional regulatory protein HVZ88_05685 ENOG4108TIT dATP pyrophosphohydrolase HVZ88_05695 ENOG4105D3W isochorismatase HVZ88_05700 ENOG41081XQ Conserved Protein HVZ88_05705 ENOG4105WJG Glutathione HVZ88_05710 ENOG4105DA6 Catalyzes the conversion of 5-methoxyuridine (mo5U) to uridine-5-oxyacetic acid (cmo5U) at position 34 in tRNA. May also participate in the methylation of uridine-5-oxyacetic acid (cmo5U) to uridine-5-oxyacetic acid methyl ester (mcmo5U) (By similarity) HVZ88_05720 ENOG4107QY8 reductase HVZ88_05725 ENOG4105CUW cytochrome C-TYPE protein HVZ88_05735 ENOG4106ZCM YecM protein HVZ88_05740 ENOG4105C75 arginyL-tRNA synthetase HVZ88_05750 ENOG4105W13 flagellar protein HVZ88_05755 ENOG4105D7B Flagellar biosynthesis protein flha HVZ88_05760 ENOG4105D00 flagellar biosynthetic protein flhB HVZ88_05765 ENOG4108KCC Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P) (By similarity) HVZ88_05770 ENOG4108VYJ response regulator receiver protein HVZ88_05775 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) HVZ88_05780 ENOG4105BZU Histidine kinase HVZ88_05785 ENOG4105C8Q Methyl-accepting chemotaxis HVZ88_05790 ENOG4105C8Q Methyl-accepting chemotaxis HVZ88_05795 ENOG4108V3W Chemotaxis protein, CheW HVZ88_05800 ENOG4105CBS Chea signal transduction histidine kinase HVZ88_05805 ENOG4105ER2 Ompa motb domain protein HVZ88_05810 ENOG4107RD7 Flagellar Motor Protein, MotA HVZ88_05815 ENOG4106CIA Functions in complex with FlhD as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region HVZ88_05825 ENOG4108VA4 Universal stress protein HVZ88_05835 ENOG4108K4C ec 3.1.3.12 HVZ88_05840 ENOG4105CNN ABC, transporter HVZ88_05845 ENOG4105C2J ABC transporter HVZ88_05850 ENOG4105DMK Periplasmic binding protein LacI transcriptional regulator HVZ88_05855 ENOG4108UEC Ferritin-like protein HVZ88_05860 ENOG4105N4N Protein of unknown function (DUF2766) HVZ88_05870 ENOG4105P23 (LipO)protein HVZ88_05875 ENOG41090A1 ferritin HVZ88_05880 ENOG4105VVZ metal-binding protein HVZ88_05885 ENOG4105E0U tyrosine-specific transport protein HVZ88_05890 ENOG4106RHG Yeca family HVZ88_05920 ENOG4105WH1 Two component transcriptional regulator luxr family HVZ88_05930 ENOG4105XVG cytoplasmic protein HVZ88_05935 ENOG4105VJY transcriptional regulator HVZ88_05940 ENOG4105CDA abc transporter atp-binding protein HVZ88_05945 ENOG4105E5Q amino acid AbC transporter HVZ88_05950 ENOG4105K6H D-cysteine desulfhydrase HVZ88_05955 ENOG4105EAB amino acid AbC transporter HVZ88_05960 ENOG4108M9K flagella biosynthesis protein FliZ HVZ88_05965 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HVZ88_05970 ENOG4105I03 Flagellin HVZ88_05975 ENOG4105DTS flagellar hook-associated HVZ88_05980 ENOG4105MQ3 flagellar protein FliS HVZ88_05990 ENOG4105E5K Alpha-amylase HVZ88_05995 ENOG4108W9D (LipO)protein HVZ88_06000 ENOG41066VF YeeE YedE family protein HVZ88_06010 ENOG4108RAV Conserved protein HVZ88_06015 ENOG4105VQ0 flagellar hook-basal body complex protein fliE HVZ88_06020 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) HVZ88_06025 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) HVZ88_06030 ENOG41090PJ Flagellar assembly protein HVZ88_06035 ENOG4108JIR Flagellum-specific ATP synthase HVZ88_06040 ENOG4105GSA Flagellar export protein flij HVZ88_06045 ENOG4105WF4 Flagellar hook-length control protein HVZ88_06050 ENOG4107ZI8 flagellar basal body-associated protein flil HVZ88_06055 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) HVZ88_06060 ENOG4105DD5 Flagellar motor switch protein HVZ88_06065 ENOG4105K0P flagellar biosynthesis protein HVZ88_06070 ENOG4105CN7 Flagellar biosynthetic protein FliP HVZ88_06080 ENOG4105D19 Role in flagellar biosynthesis (By similarity) HVZ88_06085 ENOG4107TKS colanic acid capsular biosynthesis activation protein A HVZ88_06095 ENOG4105YX3 cellular response to acidity HVZ88_06110 ENOG4105VNZ cytoplasmic protein HVZ88_06115 ENOG4105CKW Inner membrane protein yedI HVZ88_06120 ENOG4105FDR Membrane HVZ88_06125 ENOG41090BB DNA mismatch endonuclease (vsr) HVZ88_06130 ENOG4105DVF Cytosine-specific methyltransferase HVZ88_06135 ENOG4105EST Metal Dependent Phosphohydrolase HVZ88_06140 ENOG4105Y0K Inner membrane protein YedR HVZ88_06145 ENOG4105ZIT Porin Gram-negative type HVZ88_06155 ENOG4107ZY3 Histidine kinase HVZ88_06160 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HVZ88_06165 ENOG4105VT2 5-hydroxyisourate hydrolase HVZ88_06170 ENOG4105CCD The exact function is not known. Can catalyze the reduction of a variety of substrates like dimethyl sulfoxide, trimethylamine N-oxide, phenylmethyl sulfoxide and L-methionine sulfoxide. Cannot reduce cyclic N-oxides. Shows no activity as sulfite oxidase (By similarity) HVZ88_06180 ENOG4108MEK Metal-binding protein YodA HVZ88_06185 ENOG4108VKM cytochrome b561 HVZ88_06235 ENOG4105CSH Transporter HVZ88_06240 ENOG4105FYV Amp nucleosidase HVZ88_06245 ENOG4105CDY transcriptional regulatory protein HVZ88_06255 ENOG4105UQX Mate efflux family protein HVZ88_06265 ENOG4107R11 Transcriptional regulator HVZ88_06270 ENOG4106P55 Transcriptional regulator HVZ88_06315 ENOG41080HJ 6-phospho 3-hexuloisomerase HVZ88_06320 ENOG4105CHR reductase HVZ88_06325 ENOG4105DJV ribulose-phosphate 3-epimerase HVZ88_06330 ENOG4105DT3 PTS system, galactitol-specific IIc component HVZ88_06335 ENOG4105K18 The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane (By similarity) HVZ88_06345 ENOG4105E98 transcriptional regulator DeoR family HVZ88_06350 ENOG4108YZG isomerase HVZ88_06355 ENOG4105DT3 PTS system, galactitol-specific IIc component HVZ88_06360 ENOG4105K18 The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane (By similarity) HVZ88_06365 ENOG4108X7Y Mannitol-specific cryptic phosphotransferase enzyme iia HVZ88_06375 ENOG4108PXI ErfK YbiS YcfS YnhG HVZ88_06390 ENOG4108YZT Adenosylcobinamide kinase HVZ88_06410 ENOG4105DR8 Membrane HVZ88_06420 ENOG4105DZ1 carboxypeptidase HVZ88_06425 ENOG4105CJB Exodeoxyribonuclease I HVZ88_06435 ENOG4105CUC YeeE YedE family protein HVZ88_06440 ENOG4105CUB amino acid HVZ88_06450 ENOG4105EQ1 Transcriptional regulator HVZ88_06455 ENOG4107SRH Nad-dependent epimerase dehydratase HVZ88_06470 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) HVZ88_06480 ENOG4105ECC imidazole-glycerol-phosphate dehydratase HVZ88_06485 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) HVZ88_06495 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) HVZ88_06505 ENOG4108KPN Confers a modal distribution of chain length on the O- antigen component of lipopolysaccharide (LPS). Gives rise to a reduced number of short chain molecules and increases in numbers of longer molecules, with a modal value of 13 (in strain O111 M92) and of 17 (in strain K12) HVZ88_06510 ENOG4105C6Y Udp-glucose 6-dehydrogenase HVZ88_06515 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) HVZ88_06520 ENOG4108MKI Glycosyl transferase, family 2 HVZ88_06535 ENOG4105H63 Glycosyl transferase, family 2 HVZ88_06550 ENOG4105D5D udp-galactopyranose mutase HVZ88_06555 ENOG4105ER6 polysaccharide biosynthesis protein HVZ88_06560 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase HVZ88_06565 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) HVZ88_06570 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase HVZ88_06575 ENOG4105C1B dTDP-glucose 4-6-dehydratase HVZ88_06580 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase HVZ88_06585 ENOG4105G1A colanic acid biosynthesis protein HVZ88_06590 ENOG4107T8Q Glycosyl transferase (Group 1 HVZ88_06595 ENOG4105C74 pyruvyl transferase HVZ88_06600 ENOG4105PSV Polysaccharide Biosynthesis Protein HVZ88_06605 ENOG4105D3Q Sugar transferase HVZ88_06610 ENOG4107QKV phosphomannomutase HVZ88_06615 ENOG4105CJT Mannose-1-phosphate guanylyltransferase HVZ88_06620 ENOG4106CD9 glycosyl transferase group 1 HVZ88_06625 ENOG4105FGF GDP-mannose mannosyl hydrolase HVZ88_06630 ENOG4105C30 Nad-dependent epimerase dehydratase HVZ88_06635 ENOG4105C0K Gdp-mannose 4,6-dehydratase HVZ88_06640 ENOG4108Z90 colanic acid biosynthesis acetyltransferase wcaF HVZ88_06645 ENOG4105ECJ Glycosyl Transferase HVZ88_06650 ENOG4108NYJ Colanic acid HVZ88_06655 ENOG4107RXY Glycosyl transferase HVZ88_06660 ENOG41068PY Colanic acid biosynthesis acetyltransferase wcaB HVZ88_06665 ENOG41090RK glycosyl transferase HVZ88_06670 ENOG4105D75 Capsular exopolysaccharide family HVZ88_06675 ENOG4105KJF protein tyrosine phosphatase HVZ88_06680 ENOG4105DAY polysaccharide export protein HVZ88_06690 ENOG4105EE5 Membrane protein terC HVZ88_06695 ENOG4108GAE asmA family HVZ88_06705 ENOG4105DBI uridine monophosphokinase HVZ88_06710 ENOG4105BZU Histidine kinase HVZ88_06715 ENOG4105D03 DNA-3-methyladenine glycosylase II HVZ88_06720 ENOG4105R8A Heat shock protein HVZ88_06725 ENOG4106E1W protein with protein kinase and helix-hairpin-helix DNA-binding HVZ88_06730 ENOG4105ZD5 Uncharacterized protein conserved in bacteria (DUF2314) HVZ88_06735 ENOG4105UM3 Inherit from NOG: serine threonine phosphoprotein phosphatase HVZ88_06740 ENOG4108M24 von Willebrand factor, type A HVZ88_06765 ENOG4105BZS acriflavin resistance protein HVZ88_06775 ENOG4105EB3 Histidine kinase HVZ88_06780 ENOG4105E3W Two component transcriptional regulator (Winged helix family HVZ88_06785 ENOG4105KWI UPF0339 protein HVZ88_06790 ENOG4105CFP Peptidase U32 HVZ88_06795 ENOG41076Z6 Uncharacterized protein yegR HVZ88_06805 ENOG4107UW8 HAD-superfamily hydrolase subfamily IA variant 3 HVZ88_06810 ENOG4105IE8 Alpha-ketoglutarate permease HVZ88_06815 ENOG4105CMG Carbohydrate kinase HVZ88_06820 ENOG4105DEI Mannitol dehydrogenase HVZ88_06840 ENOG4105EF1 ribulokinase HVZ88_06845 ENOG4105IE8 Alpha-ketoglutarate permease HVZ88_06850 ENOG4105EIE fructose-bisphosphate aldolase HVZ88_06855 ENOG4105EAA nucleoside HVZ88_06860 ENOG4108KD5 ADP-ribosylation crystallin J1 HVZ88_06865 ENOG4108TFM Kinase, PfkB family HVZ88_06870 ENOG4105FDP GntR family transcriptional regulator HVZ88_06875 ENOG4108UQ1 hydrolase, family 25 HVZ88_06880 ENOG4105DWF phosphomethylpyrimidine kinase HVZ88_06900 ENOG4108Z1S Influences nickel and cobalt homeostasis. May act by modulating RcnA-mediated export of these ions to avoid excess efflux. Not involved in nickel import and does not bind nickel or cobalt ions directly HVZ88_06905 ENOG410662B Type-1 fimbrial protein HVZ88_06910 ENOG4105CW0 outer membrane usher protein HVZ88_06915 ENOG4108MQF Chaperone HVZ88_06920 ENOG41063W2 Fimbrial protein HVZ88_06925 ENOG41067AK Protein of unknown function (DUF2574) HVZ88_06930 ENOG4105D1F ATP-binding protein HVZ88_06935 ENOG4105CKH Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation (By similarity) HVZ88_06945 ENOG4108KDT Molybdate metabolism regulator HVZ88_06955 ENOG4105KKX ATPase associated with various cellular activities aaa_5 HVZ88_06965 ENOG4105DEG Vwa containing coxe family protein HVZ88_06970 ENOG410903U zinc ion binding HVZ88_06975 ENOG4108YCW (LipO)protein HVZ88_06980 ENOG4108W15 Protein of unknown function (DUF1456) HVZ88_06985 ENOG4108NEV two component transcriptional regulator, LytTR family HVZ88_06990 ENOG4108HRK Histidine kinase HVZ88_06995 ENOG4108XDN Transcriptional regulator HVZ88_07005 ENOG4105WJV Binding-protein-dependent transport systems, inner membrane component HVZ88_07010 ENOG4108IJ8 ABC transporter HVZ88_07015 ENOG4107T5X Binding-protein-dependent transport systems, inner membrane component HVZ88_07020 ENOG4107SI7 Substrate-binding region of abc-type glycine betaine transport system HVZ88_07025 ENOG4107QK4 glycoside hydrolase, family 3 domain protein HVZ88_07030 ENOG4105CXG d-lactate dehydrogenase HVZ88_07035 ENOG41061WM D-Alanyl-D-Alanine HVZ88_07040 ENOG41069YE inner membrane protein yohC HVZ88_07045 ENOG4105KHU inner membrane protein YohD HVZ88_07050 ENOG4105H9W Short-chain dehydrogenase reductase Sdr HVZ88_07055 ENOG4105ETP RND efflux system, outer membrane lipoprotein HVZ88_07065 ENOG4105FBT Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity) HVZ88_07075 ENOG41067MG lrgb family HVZ88_07085 ENOG4107GZ4 SanA protein HVZ88_07090 ENOG4105Y9N Membrane HVZ88_07095 ENOG4105BZ8 glutamate synthase HVZ88_07100 ENOG4107SJI Dehydrogenase HVZ88_07105 ENOG4108HWV )-transporter HVZ88_07110 ENOG4105C2J ABC transporter HVZ88_07115 ENOG4105EMA Periplasmic binding protein LacI transcriptional regulator HVZ88_07120 ENOG41060NJ transcriptional regulator HVZ88_07125 ENOG4105DHF Membrane HVZ88_07140 ENOG4105D05 Receptor HVZ88_07145 ENOG4108IQI permease HVZ88_07150 ENOG4105DUM transcriptional regulator, lysR family HVZ88_07155 ENOG4105HMI Membrane HVZ88_07160 ENOG4105EFU Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic sites (AP sites) to produce new 5'-ends that are base-free deoxyribose 5-phosphate residues. It preferentially attacks modified AP sites created by bleomycin and neocarzinostatin (By similarity) HVZ88_07165 ENOG4105DD7 kinase (PfkB family HVZ88_07170 ENOG4105D9N nucleoside HVZ88_07180 ENOG4108Y4K DNA-binding transcriptional activator HVZ88_07185 ENOG4105D9N nucleoside HVZ88_07190 ENOG4105D53 Catalyzes the hydrolysis of pseudouridine 5'-phosphate (PsiMP) to ribose 5-phosphate and uracil (By similarity) HVZ88_07195 ENOG4105DD7 kinase (PfkB family HVZ88_07200 ENOG4105DM4 PTS System HVZ88_07205 ENOG4105DE4 1-phosphofructokinase HVZ88_07210 ENOG4105DTZ bifunctional PTS system fructose-specific transporter subunit IIA HPr protein HVZ88_07215 ENOG4105S8Q sugar efflux transporter HVZ88_07220 ENOG4105KRS Proteinase inhibitor HVZ88_07230 ENOG4105DEI Mannitol dehydrogenase HVZ88_07235 ENOG4105CKI cobalamin synthesis protein HVZ88_07240 ENOG41076MN Phosphoesterase, PA-phosphatase related HVZ88_07245 ENOG4107TT5 NLP P60 protein HVZ88_07250 ENOG4105CXC rtn protein HVZ88_07255 ENOG4105E43 Extracellular solute-binding protein, family 5 HVZ88_07260 ENOG4108I5X binding-protein-dependent transport systems inner membrane Component HVZ88_07265 ENOG4108IYQ Binding-protein-dependent transport systems inner membrane component HVZ88_07270 ENOG4108JQ5 ABC transporter HVZ88_07275 ENOG4105HG6 HVZ88_07280 ENOG4105C2C drug resistance transporter, Bcr CflA HVZ88_07285 ENOG4105I08 Pseudouridine synthase HVZ88_07290 ENOG4105CFI type iii restriction protein res subunit HVZ88_07310 ENOG4105E68 Sulfatase HVZ88_07335 ENOG4105WH1 Two component transcriptional regulator luxr family HVZ88_07340 ENOG4105KWW Biogenesis protein HVZ88_07345 ENOG4107QX9 Thiol disulfide interChange protein HVZ88_07350 ENOG4105DA4 cytochrome c-type biogenesis protein HVZ88_07360 ENOG4105X3C heme exporter protein HVZ88_07365 ENOG41060IM Heme exporter protein HVZ88_07370 ENOG4105CA5 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes (By similarity) HVZ88_07375 ENOG4107EV4 once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system (By similarity) HVZ88_07380 ENOG4105CUW cytochrome C-TYPE protein HVZ88_07385 ENOG4108ZMS Electron transfer subunit of the periplasmic nitrate reductase complex NapAB (By similarity) HVZ88_07390 ENOG4105GXZ Ferredoxin-type protein NapH HVZ88_07395 ENOG4108BGM Quinol dehydrogenase periplasmic component HVZ88_07400 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) HVZ88_07405 ENOG41061Q0 Assembly protein for periplasmic nitrate reductase HVZ88_07410 ENOG4108ZNS ferredoxin-type protein NapF HVZ88_07425 ENOG4105DWT malate dehydrogenase (quinone) HVZ88_07430 ENOG4105IBP Cyclic peptide transporter HVZ88_07435 ENOG4105CF1 Alkylated DNA repair protein HVZ88_07440 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) HVZ88_07445 ENOG4105CJ2 (LipO)protein HVZ88_07450 ENOG4105FCK Membrane HVZ88_07455 ENOG4105E3G Phosphotransfer intermediate protein in two-component regulatory system with RcsBC HVZ88_07460 ENOG41068CG regulatoR HVZ88_07465 ENOG4105BZU Histidine kinase HVZ88_07470 ENOG4105BZU Histidine kinase HVZ88_07475 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family HVZ88_07480 ENOG4107QP7 CoA-transferase subunit A HVZ88_07485 ENOG4107QNJ CoA-transferase subunit B HVZ88_07490 ENOG4105CRW Short chain fatty acid transporter HVZ88_07495 ENOG4105CHU acetyl-coa acetyltransferase HVZ88_07500 ENOG4105EDV vault protein HVZ88_07505 ENOG41081SK signal peptide protein HVZ88_07515 ENOG4108QJJ Protein of unknown function (DUF1175) HVZ88_07520 ENOG4107FKF Uncharacterized protein conserved in bacteria (DUF2138) HVZ88_07525 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HVZ88_07535 ENOG4107GHC outer membrane autotransporter HVZ88_07540 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HVZ88_07545 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HVZ88_07550 ENOG4105XPH Ferredoxin HVZ88_07555 ENOG4105FQR PH-inducible protein involved in stress response HVZ88_07565 ENOG4106MZZ glycerophosphoryl diester phosphodiesterase HVZ88_07570 ENOG4105CXY transporter HVZ88_07575 ENOG4107R5Y anaerobic glycerol-3-phosphate dehydrogenase, subunit A HVZ88_07580 ENOG4108KJ0 anaerobic glycerol-3-phosphate dehydrogenase, subunit B HVZ88_07585 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) HVZ88_07590 ENOG4105DNE Transposase HVZ88_07605 ENOG4105CSP Major Facilitator Superfamily HVZ88_07610 ENOG4105CXK mandelate racemase muconate lactonizing HVZ88_07615 ENOG4107258 Transcriptional regulator HVZ88_07620 ENOG4108EWA cinA-like protein HVZ88_07625 ENOG4108UII YfaZ family HVZ88_07630 ENOG4108RJ7 Catalyzes the hydrolysis of nucleoside triphosphates, with a preference for pyrimidine deoxynucleoside triphosphates (dUTP, dTTP and dCTP) (By similarity) HVZ88_07635 ENOG4108WMR Catalyzes the dephosphorylation of heptose(II) of the outer membrane lipopolysaccharide core (By similarity) HVZ88_07650 ENOG4105C3I Nad-dependent epimerase dehydratase HVZ88_07660 ENOG4105SA9 Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity) HVZ88_07670 ENOG4105U65 Translocates 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol (alpha-L-Ara4N-phosphoundecaprenol) from the cytoplasmic to the periplasmic side of the inner membrane (By similarity) HVZ88_07675 ENOG4106GZG polymyxin resistance protein B HVZ88_07680 ENOG4105CEY Amp-dependent synthetase and ligase HVZ88_07685 ENOG4105DNI Converts SHCHC to OSB (By similarity) HVZ88_07690 ENOG4108IPT Naphthoate synthase HVZ88_07695 ENOG4107J5P Catalyzes a proton abstraction reaction that results in 2,5-elimination of pyruvate from 2-succinyl-5-enolpyruvyl-6- hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC) and the formation of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC). Is also able to catalyze the hydrolysis of the thioester bond in palmitoyl-CoA in vitro (By similarity) HVZ88_07705 ENOG4105E4F Isochorismate synthase HVZ88_07710 ENOG4105TNS Conserved Protein HVZ88_07715 ENOG4107YB6 acetyltransferase, (GNAT) family HVZ88_07735 ENOG4105GDX Domain of unknown function (DUF1877) HVZ88_07745 ENOG4105C8S subunit m HVZ88_07750 ENOG4105D65 subunit l HVZ88_07760 ENOG4107UFS subunit j HVZ88_07775 ENOG4107R0R NADH dehydrogenase subunit g HVZ88_07780 ENOG4107QIZ NADH dehydrogenase HVZ88_07785 ENOG4105GKE subunit e HVZ88_07805 ENOG4107NQ8 LysR family Transcriptional regulator HVZ88_07810 ENOG4105CHM Aminotransferase HVZ88_07815 ENOG4105DK2 UPF0207 protein HVZ88_07820 ENOG4107QWE )-transporter HVZ88_07825 ENOG4105EVE HAD-superfamily hydrolase subfamily IA variant 3 HVZ88_07830 ENOG4105XWI UPF0304 protein HVZ88_07840 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) HVZ88_07845 ENOG4105C6K Malic enzyme HVZ88_07850 ENOG4105CSX c4-dicarboxylate anaerobic carrier HVZ88_07855 ENOG4105PTV Nudix Hydrolase HVZ88_07860 ENOG4108RE9 Phosphodiesterase HVZ88_07865 ENOG4108SHQ Glutathione S-transferase HVZ88_07870 ENOG4105CYM Glutathione S-transferase HVZ88_07875 ENOG4105KKP D-erythro-7,8-dihydroneopterin triphosphate 2'-epimerase HVZ88_07880 ENOG4105ECP epimerase HVZ88_07885 ENOG4105DNE Transposase HVZ88_07890 ENOG4108JEH abc transporter atp-binding protein HVZ88_07895 ENOG4106YG3 ABC transporter HVZ88_07900 ENOG4105DSP amino acid AbC transporter HVZ88_07905 ENOG4105E89 ABC transporter HVZ88_07910 ENOG4105E89 ABC transporter HVZ88_07915 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase HVZ88_07920 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase HVZ88_07925 ENOG4105E96 Colicin v production protein HVZ88_07930 ENOG4108S3P Sporulation domain protein HVZ88_07935 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase HVZ88_07945 ENOG4105DQR SNARE associated Golgi HVZ88_07955 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) HVZ88_07960 ENOG4105CJ0 Catalyzes the oxidation of erythronate-4-phosphate to 3- hydroxy-2-oxo-4-phosphonooxybutanoate (By similarity) HVZ88_07965 ENOG4106WZ1 flagella biosynthesis regulator HVZ88_07970 ENOG4105F9N Major Facilitator Superfamily HVZ88_07975 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) HVZ88_07980 ENOG4105CWG Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity) HVZ88_07985 ENOG4105MH2 YfcL protein HVZ88_07990 ENOG4108BPE -transporting atpase HVZ88_07995 ENOG4105EJ9 Membrane HVZ88_08000 ENOG4105HPZ Involved in the removal of murein from the sacculus. May also facilitate integration of nascent murein strands into the sacculus by cleaving the peptide bonds between neighboring strands in mature murein (By similarity) HVZ88_08010 ENOG4105C76 Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity) HVZ88_08025 ENOG4105US4 fimbrial-like protein yfcP HVZ88_08030 ENOG4105UGQ Fimbrial HVZ88_08035 ENOG4105NEV Fimbrial HVZ88_08040 ENOG4108FZ9 Chaperone HVZ88_08045 ENOG4106PG1 outer membrane usher protein HVZ88_08055 ENOG4108BY2 phosphohistidine phosphatase HVZ88_08060 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase HVZ88_08065 ENOG4105CHU acetyl-coa acetyltransferase HVZ88_08070 ENOG4105KZW UPF0381 protein HVZ88_08075 ENOG4105CKF membrane protein involved in aromatic hydrocarbon degradation HVZ88_08085 ENOG410903C (LipO)protein HVZ88_08090 ENOG4105S64 Formate nitrite transporter HVZ88_08110 ENOG4105C6Z Gluconate HVZ88_08120 ENOG4105C0R drug resistance transporter emrb qaca subfamily HVZ88_08125 ENOG4105CW7 secretion protein, HlyD family HVZ88_08130 ENOG4108WQH regulatoR HVZ88_08135 ENOG4105BZU Histidine kinase HVZ88_08140 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F HVZ88_08145 ENOG4108N2Y auxin Efflux HVZ88_08150 ENOG4105CFN oxalyl-CoA decarboxylase HVZ88_08160 ENOG4108V08 YfdX protein HVZ88_08170 ENOG4105W9M Membrane HVZ88_08175 ENOG4105D1S lipid A biosynthesis HVZ88_08185 ENOG4105CHM Aminotransferase HVZ88_08190 ENOG4108HRK Histidine kinase HVZ88_08195 ENOG4105DY9 regulatoR HVZ88_08200 ENOG4108CIP transcriptional regulator HVZ88_08205 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) HVZ88_08210 ENOG4105CN9 Peptidase m42 family protein HVZ88_08215 ENOG4105DC7 peptidase M24 HVZ88_08220 ENOG410863U PTS System HVZ88_08225 ENOG4105R6B The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane (By similarity) HVZ88_08235 ENOG4105VCT ion-transport protein YfeO HVZ88_08240 ENOG4109076 Conserved Protein HVZ88_08250 ENOG4105D9N nucleoside HVZ88_08255 ENOG4108KMM Diguanylate cyclase HVZ88_08270 ENOG4105HZG regulatoR HVZ88_08275 ENOG4105GXM Putative transcription regulator (DUF1323) HVZ88_08305 ENOG4105CN8 Transcriptional regulator HVZ88_08315 ENOG4105EAA nucleoside HVZ88_08320 ENOG4107U5R The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity) HVZ88_08325 ENOG4108NFH Sugar hydrolase HVZ88_08330 ENOG4108M0I Transcriptional regulator HVZ88_08335 ENOG4105DHU Bile acid HVZ88_08340 ENOG4105VRT cytoplasmic protein HVZ88_08345 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) HVZ88_08360 ENOG4105C6T cysteine synthase HVZ88_08370 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) HVZ88_08375 ENOG4105C5Y PTS System HVZ88_08385 ENOG4105M0Y HVZ88_08390 ENOG4105WEC Molybdate metabolism regulator HVZ88_08395 ENOG4105C6T cysteine synthase HVZ88_08400 ENOG4108IJ6 ABC transporter HVZ88_08405 ENOG4105ECW sulfate abc transporter HVZ88_08410 ENOG4108I5D sulfate abc transporter HVZ88_08415 ENOG4108J2H Sulfate ABC transporter periplasmic sulfate-binding protein HVZ88_08420 ENOG4105I7Z Short-chain dehydrogenase reductase Sdr HVZ88_08425 ENOG4108PSC Represses the expression of the murPQ operon involved in the uptake and degradation of N-acetylmuramic acid (MurNAc). Binds to two adjacent inverted repeats within the operator region. MurNAc 6-phosphate, the substrate of MurQ, is the specific inducer that weakens binding of MurR to the operator (By similarity) HVZ88_08435 ENOG4105C5Y PTS System HVZ88_08440 ENOG4107S1E Beta-lactamase HVZ88_08445 ENOG4105EZR dyp-type peroxidase family protein HVZ88_08450 ENOG4105E7K (LipO)protein HVZ88_08455 ENOG4105QZU Inner membrane protein YfeZ HVZ88_08460 ENOG4108R6G acetyltransferase HVZ88_08465 ENOG4108KNB n-acetylmuramoyl-l-alanine amidase HVZ88_08475 ENOG4108K3Z AraC family transcriptional regulator HVZ88_08480 ENOG4108X49 Ethanolamine utilization protein EutK HVZ88_08485 ENOG4106D67 ethanolamine utilization protein HVZ88_08495 ENOG4105CPD ethanolamine ammonia-lyase HVZ88_08500 ENOG4105DYY Reactivating factor for ethanolamine ammonia lyase HVZ88_08505 ENOG4105ENY Ethanolamine utilization protein eutH HVZ88_08510 ENOG4105C0A alcohol dehydrogenase HVZ88_08515 ENOG4107RWI ethanolamine utilization protein eutJ HVZ88_08520 ENOG4108EKI Dehydrogenase HVZ88_08525 ENOG4105WVM ethanolamine utilization protein EutN carboxysome structural protein Ccml HVZ88_08530 ENOG4105KNY Microcompartments protein HVZ88_08535 ENOG4107WUY phosphate acetyltransferase HVZ88_08540 ENOG4108PFF ethanolamine utilization cobalamin adenosyltransferase HVZ88_08545 ENOG4105NDK ethanolamine utilization protein HVZ88_08550 ENOG4106S4J ethanolamine utilization protein EutP HVZ88_08555 ENOG4108VJN May be involved in the formation of a specific microcompartment in the cell in which the metabolism of potentially toxic by-products takes place HVZ88_08560 ENOG4105C6K Malic enzyme HVZ88_08565 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) HVZ88_08570 ENOG4105CV1 Transketolase (EC 2.2.1.1) HVZ88_08575 ENOG4108PVD exported protein HVZ88_08585 ENOG4105BZ8 glutamate synthase HVZ88_08590 ENOG4105BZU Histidine kinase HVZ88_08595 ENOG4105BZS acriflavin resistance protein HVZ88_08605 ENOG4105KUZ arsenate reductase HVZ88_08620 ENOG4106KED esterase YpfH HVZ88_08625 ENOG4105E0I Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP) (By similarity) HVZ88_08630 ENOG4105CGZ zinc metallopeptidase HVZ88_08640 ENOG4107EG0 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) HVZ88_08650 ENOG4105RH4 Glycine cleavage system transcriptional repressor HVZ88_08655 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen HVZ88_08660 ENOG4108MFN small subunit of hydrogenase-3, iron-sulfur protein (part of formate hydrogenlyase (FHL) complex) HVZ88_08670 ENOG4107TDF Formate hydrogenlyase subunit 4 HVZ88_08675 ENOG4105D65 subunit l HVZ88_08680 ENOG4107WQX hydrogenase 4 membrane subunit HVZ88_08685 ENOG4108JPZ Monovalent cation H antiporter subunit D HVZ88_08690 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HVZ88_08700 ENOG4105C47 NADH ubiquinone oxidoreductase 20 kda subunit HVZ88_08705 ENOG4105I6X formate hydrogenlyase maturation HVZ88_08710 ENOG4108JUA Transcriptional regulator HVZ88_08715 ENOG4105TMB Formate nitrite transporter HVZ88_08720 ENOG4105C02 permease HVZ88_08725 ENOG4105ERG peptidase m48, ste24p HVZ88_08730 ENOG4105K89 arsenate reductase HVZ88_08735 ENOG4108KZ1 Mediates the interaction of DNA replication inititator protein DnaA with DNA polymerase subunit beta sliding clamp (dnaN). Stimulates hydrolysis of ATP-DnaA to ADP-DnaA, rendering DnaA inactive for reinititation, a process called regulatory inhibition of DnaA or RIDA (By similarity) HVZ88_08740 ENOG4105C2W permease HVZ88_08750 ENOG4105CXB phosphoribosylaminoimidazole synthetase HVZ88_08755 ENOG4108V3E phosphoribosylglycinamide formyltransferase HVZ88_08760 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) HVZ88_08765 ENOG4105C9X ppx gppa phosphatase HVZ88_08770 ENOG4105BZU Histidine kinase HVZ88_08780 ENOG41062G3 Protein of unknown function (DUF2633) HVZ88_08785 ENOG4108ZMA Outer membrane lipoprotein HVZ88_08790 ENOG41066DY Membrane HVZ88_08795 ENOG4105CM0 Catalyzes the synthesis of GMP from XMP (By similarity) HVZ88_08800 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) HVZ88_08805 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) HVZ88_08810 ENOG4105VPD cellular component movement HVZ88_08825 ENOG4105N21 Membrane HVZ88_08855 ENOG4108JQB penicillin-binding protein 1C HVZ88_08860 ENOG4105DN3 alpha-2-macroglobulin domain protein HVZ88_08865 ENOG4105KHC sulfurtransferase HVZ88_08870 ENOG4105YYA enhanced serine sensitivity protein SseB HVZ88_08875 ENOG4105BZ6 Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity) HVZ88_08880 ENOG4105WVQ Fe-S assembly protein IscX HVZ88_08885 ENOG4108ZIT Ferredoxin, 2FE-2S HVZ88_08905 ENOG4107XTC May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins HVZ88_08925 ENOG4105ECY inositol monophosphatase HVZ88_08930 ENOG4107XM9 (LipO)protein HVZ88_08935 ENOG4108SER Transposase HVZ88_08945 ENOG4105D8G Major Facilitator superfamily HVZ88_08950 ENOG4108W5M transcriptional regulator HVZ88_08955 ENOG4105FUY alpha subunit HVZ88_08970 ENOG4108QJ2 2,3-dihydroxy-2,3-dihydrophenylpropionate dehydrogenase HVZ88_08980 ENOG4108SB3 DoxX Family HVZ88_08985 ENOG4108ZKT aldose 1-epimerase HVZ88_08990 ENOG4105CPQ Dehydrogenase HVZ88_08995 ENOG4105CNN ABC, transporter HVZ88_09000 ENOG4108F37 ATP-binding component of a transport system HVZ88_09005 ENOG4108SER Transposase HVZ88_09010 ENOG4108F37 ATP-binding component of a transport system HVZ88_09015 ENOG4105FCA ABC transporter periplasmic-binding protein YphF HVZ88_09020 ENOG4107HQ7 repeat protein HVZ88_09025 ENOG4108NZE NAGC-like transcriptional regulator HVZ88_09035 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) HVZ88_09045 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family HVZ88_09050 ENOG4108SKK alpha helix protein HVZ88_09055 ENOG4107WP9 Histidine kinase HVZ88_09070 ENOG4108Z6B deaminase HVZ88_09075 ENOG4105HYY HAD superfamily (Subfamily IF) hydrolase, YfhB HVZ88_09080 ENOG4106G6Q Transcriptional regulator HVZ88_09085 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding HVZ88_09100 ENOG4105CSZ Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity) HVZ88_09120 ENOG4105C3F Signal peptidase i HVZ88_09130 ENOG4105WMJ Positive regulator of sigma E, RseC MucC HVZ88_09135 ENOG4105VQK sigma E regulatory protein, MucB RseB HVZ88_09140 ENOG41069PW sigma-e factor negative regulatory protein HVZ88_09145 ENOG4105EMN RNA polymerase sigma factor HVZ88_09155 ENOG4108IYU L-aspartate oxidase HVZ88_09165 ENOG4105C1J atp-dependent rna helicase HVZ88_09170 ENOG41090KR LysR family transcriptional Regulator HVZ88_09190 ENOG4105EIB trna rrna methyltransferase HVZ88_09195 ENOG4105K63 Thioredoxin HVZ88_09200 ENOG4106IUH DTW domain containing protein HVZ88_09205 ENOG4105CD5 CoA-binding domain protein HVZ88_09210 ENOG4105JIM Phosphatidylserine synthase HVZ88_09215 ENOG4105T42 (LipO)protein HVZ88_09220 ENOG4105CSH Transporter HVZ88_09245 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit HVZ88_09250 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase HVZ88_09255 ENOG4105C34 Pseudouridine synthase HVZ88_09260 ENOG4106SNF Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane HVZ88_09265 ENOG4108WPH sigma 54 modulation protein ribosomal protein S30EA HVZ88_09275 ENOG4105CQC Prephenate dehydratase HVZ88_09280 ENOG4105EHE chorismate mutase- prephenate dehydrogenase HVZ88_09285 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) HVZ88_09290 ENOG4105QP9 Protein of unknown function (DUF2799) HVZ88_09295 ENOG4108WS1 HVZ88_09300 ENOG4108KHX Diguanylate cyclase HVZ88_09305 ENOG41090EK ompa motb domain protein HVZ88_09330 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY HVZ88_09335 ENOG4106KVJ cytochrome C assembly protein HVZ88_09340 ENOG4108JU6 CBS domain protein HVZ88_09355 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) HVZ88_09360 ENOG4105YRI Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) HVZ88_09370 ENOG4108Z1B Cyclase dehydrase HVZ88_09390 ENOG4105ZTC transcriptional activator, Ogr delta HVZ88_09430 ENOG4108C33 Resolvase HVZ88_09440 ENOG4108US3 tail fiber assembly HVZ88_09445 ENOG4105PTU response to oxidative stress HVZ88_09535 ENOG4105ED4 portal protein HVZ88_09565 ENOG4105DFE Dna adenine methylase HVZ88_09570 ENOG4105KSC Transcriptional regulator, TraR DksA family HVZ88_09605 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HVZ88_09615 ENOG4105DFP Integrase HVZ88_09625 ENOG4105FA0 parb-like partition protein HVZ88_09640 ENOG4105E54 alpha-amylase HVZ88_09650 ENOG4105EK3 May be involved in the control of utilization of gamma- aminobutyric acid (By similarity) HVZ88_09655 ENOG4105D5U fad dependent oxidoreductase HVZ88_09660 ENOG4105C26 Dehydrogenase HVZ88_09665 ENOG4108JPW Aminotransferase HVZ88_09670 ENOG4105C85 amino acid HVZ88_09675 ENOG4108PVQ transcriptional regulator HVZ88_09680 ENOG4109066 lysm domain bon superfamily protein HVZ88_09685 ENOG4105VPI YqaE family transport protein HVZ88_09690 ENOG41080HT Transcriptional regulator, arsr family HVZ88_09695 ENOG4108V62 Rhodanese domain protein HVZ88_09700 ENOG4108X73 DNA- binding protein HVZ88_09705 ENOG4108RNS Exports L-alanine (By similarity) HVZ88_09710 ENOG4108WMJ Protein of unknown function (DUF2002) HVZ88_09715 ENOG4108ZQZ Bacterial protein of unknown function (DUF883) HVZ88_09720 ENOG4105WAZ (Glutaredoxin-like protein) NrdH HVZ88_09730 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HVZ88_09735 ENOG4107R25 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HVZ88_09740 ENOG4108IJ7 Glycine betaine HVZ88_09745 ENOG4108HQS Glycine betaine HVZ88_09750 ENOG4105GIJ Glycine betaine HVZ88_09760 ENOG4108UMN azlc family HVZ88_09765 ENOG4105ZED uncharacterized protein ygaH HVZ88_09770 ENOG4105NTK Transcriptional repressor Mpra HVZ88_09775 ENOG4105CW7 secretion protein, HlyD family HVZ88_09780 ENOG4105C0R drug resistance transporter emrb qaca subfamily HVZ88_09795 ENOG4105W39 Membrane HVZ88_09800 ENOG4107VXZ Hydrolase HVZ88_09830 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) HVZ88_09835 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) HVZ88_09850 ENOG4107TH8 cina domain protein HVZ88_09855 ENOG4105CVE Lytic murein transglycosylase HVZ88_09860 ENOG410787A Pts system, glucitol sorbitol-specific HVZ88_09875 ENOG4107QMF Sorbitol-6-phosphate dehydrogenase HVZ88_09880 ENOG4105J92 DNA-binding transcriptional activator GutM HVZ88_09885 ENOG410804X Transcriptional regulator HVZ88_09890 ENOG4105C2X Arabinose 5-phosphate isomerase HVZ88_09895 ENOG4108JUA Transcriptional regulator HVZ88_09905 ENOG4108EQM faD-dependent pyridine nucleotide-disulfide oxidoreductase HVZ88_09910 ENOG4105C8H hydrogenase maturation protein Hypf HVZ88_09915 ENOG4108RC0 Electron transport protein HVZ88_09920 ENOG4105DDV Transcriptional regulator (LacI family HVZ88_09925 ENOG4105C5Y PTS System HVZ88_09930 ENOG4105CS2 ec 3.2.1.21 HVZ88_09935 ENOG4108MG9 hydrogenase 3 maturation protease HVZ88_09940 ENOG4105I6X formate hydrogenlyase maturation HVZ88_09945 ENOG4105C47 NADH ubiquinone oxidoreductase 20 kda subunit HVZ88_09950 ENOG4108RG7 formate hydrogenlyase complex iron-sulfur subunit HVZ88_09955 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HVZ88_09960 ENOG4107TDF Formate hydrogenlyase subunit 4 HVZ88_09965 ENOG4107R30 NADH dehydrogenase HVZ88_09970 ENOG4108MFN small subunit of hydrogenase-3, iron-sulfur protein (part of formate hydrogenlyase (FHL) complex) HVZ88_09975 ENOG4108VRC Formate hydrogenlyase regulatory protein hycA HVZ88_09980 ENOG410816D Probably plays a role in a hydrogenase nickel cofactor insertion step (By similarity) HVZ88_09985 ENOG4107RSS Hydrogenase accessory protein HypB HVZ88_09990 ENOG41083WG hydrogenase assembly chaperone HVZ88_09995 ENOG4105CQS hydrogenase expression formation protein HypD HVZ88_10000 ENOG4105C45 hydrogenase expression formation protein (HypE) HVZ88_10005 ENOG4108JUA Transcriptional regulator HVZ88_10010 ENOG4105VXR cytoplasmic protein HVZ88_10025 ENOG4105MEW serine threonine protein phosphatase HVZ88_10030 ENOG4105MVE transcriptional regulator HVZ88_10035 ENOG4105ZXK Dehydrogenase HVZ88_10040 ENOG4105G63 Type III effector Hrp-dependent HVZ88_10045 ENOG4105FB2 class II Aldolase HVZ88_10050 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) HVZ88_10055 ENOG4105C6Z Gluconate HVZ88_10060 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HVZ88_10065 ENOG4108K5P (LipO)protein HVZ88_10100 ENOG4105N0Z inner membrane protein ygbE HVZ88_10115 ENOG4105C11 sulfate adenylyltransferase), subunit 2 HVZ88_10120 ENOG4108MXK alkaline phosphatase isozyme conversion HVZ88_10125 ENOG4105PWE CRISPR-associated protein cas2 HVZ88_10135 ENOG4108SER Transposase HVZ88_10140 ENOG4107635 Hok Gef family protein HVZ88_10150 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) HVZ88_10160 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase HVZ88_10165 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase HVZ88_10170 ENOG4105WQV ferredoxin-like protein HVZ88_10175 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator HVZ88_10180 ENOG4105YBM electron transfer flavoprotein subunit ygcQ HVZ88_10185 ENOG4106IKH Electron transfer flavoprotein HVZ88_10190 ENOG4105C54 Major Facilitator superfamily HVZ88_10195 ENOG4107R3A FAD linked oxidase domain protein HVZ88_10200 ENOG4105CHR reductase HVZ88_10205 ENOG4108ITV Inner membrane protein yqcE HVZ88_10210 ENOG4108CWB sugar kinase ygcE HVZ88_10215 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) HVZ88_10225 ENOG4105HA9 of methanol dehydrogenase type HVZ88_10240 ENOG4105DXN mazG family HVZ88_10245 ENOG4105MZG transcriptional modulator of maze toxin, mazf HVZ88_10250 ENOG4106A2Z transcriptional regulator antitoxin, MazE HVZ88_10255 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) HVZ88_10265 ENOG4105BZU Histidine kinase HVZ88_10270 ENOG4105EQX glucarate dehydratase HVZ88_10275 ENOG4105EQX glucarate dehydratase HVZ88_10280 ENOG4105DJB Major Facilitator Superfamily HVZ88_10285 ENOG4105QDK Flavodoxin HVZ88_10290 ENOG4105DR9 pseudouridine synthase HVZ88_10295 ENOG4105WP7 tRNA pseudouridine synthase C HVZ88_10310 ENOG4105EWT decarboxylase family HVZ88_10315 ENOG4105C44 Serine transporter HVZ88_10320 ENOG4105EJQ L-serine dehydratase HVZ88_10330 ENOG4105C0A alcohol dehydrogenase HVZ88_10335 ENOG4107W7X Aldolase HVZ88_10345 ENOG4105EHF Converts the aldose L-fucose into the corresponding ketose L-fuculose (By similarity) HVZ88_10350 ENOG4105CMG Carbohydrate kinase HVZ88_10360 ENOG4107EDW L-fucose operon activator HVZ88_10370 ENOG4105M08 Membrane HVZ88_10375 ENOG4105ETT transcriptional Regulator, LysR family HVZ88_10380 ENOG4105M5B (LipO)protein HVZ88_10385 ENOG4105C9B Cysteine desulfurase HVZ88_10390 ENOG4105P9C Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity) HVZ88_10395 ENOG4105CUZ uba thif-type nad fad binding protein HVZ88_10400 ENOG4105CA3 membrane-bound lytic murein transglycosylase HVZ88_10420 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase HVZ88_10425 ENOG4108EKC n-acetylglutamate synthase HVZ88_10430 ENOG4107QYX exodeoxyribonuclease v alpha HVZ88_10435 ENOG4107QKA exodeoxyribonuclease V beta HVZ88_10440 ENOG4107QXK peptidase HVZ88_10445 ENOG4105DSY exodeoxyribonuclease V, gamma HVZ88_10450 ENOG4105RVB Prepilin peptidase dependent protein c HVZ88_10455 ENOG4105SEN Protein of unknown function (DUF2509) HVZ88_10460 ENOG4105JCS prepilin peptidase dependent protein HVZ88_10465 ENOG4105IPU prepilin peptidase dependent protein A HVZ88_10480 ENOG4108HRM phosphoenolpyruvate--protein phosphotransferase HVZ88_10495 ENOG4105EE5 Membrane protein terC HVZ88_10500 ENOG4105SUV lipoprotein YgdR HVZ88_10505 ENOG4105CPC Aldo Keto reductase HVZ88_10510 ENOG4107S74 Lysophospholipid transporter LplT HVZ88_10515 ENOG4105CEY Amp-dependent synthetase and ligase HVZ88_10520 ENOG41060NJ transcriptional regulator HVZ88_10530 ENOG4105RQF LysR family Transcriptional regulator HVZ88_10540 ENOG4107QNK )-transporter HVZ88_10545 ENOG4105CHR reductase HVZ88_10555 ENOG4105CHU acetyl-coa acetyltransferase HVZ88_10560 ENOG4108MHD transport protein HVZ88_10565 ENOG4105ISV protein with bipartite regulator domain HVZ88_10570 ENOG4108TC1 Transcriptional regulator HVZ88_10575 ENOG4105FV3 HVZ88_10600 ENOG4108YAB Invasion protein HVZ88_10630 ENOG4108RBT type iii secretion HVZ88_10635 ENOG4106BTR HVZ88_10640 ENOG4105Y7Q type iii secretion HVZ88_10645 ENOG4108RC9 Type III secretion system protein HVZ88_10660 ENOG4108M6W surface presentation of antigens protein SpaS HVZ88_10665 ENOG4108M6W surface presentation of antigens protein SpaS HVZ88_10670 ENOG4108TN6 type iii secretion HVZ88_10675 ENOG4105U07 type iii secretion HVZ88_10680 ENOG41075IY surface presentation of antigens protein SpaP HVZ88_10700 ENOG4108K5P (LipO)protein HVZ88_10705 ENOG4105C7W Xanthine dehydrogenase HVZ88_10710 ENOG4108HR6 Dehydrogenase HVZ88_10715 ENOG4108UTP (2Fe-2S)-binding domain protein HVZ88_10720 ENOG4108JUB Transcriptional regulator HVZ88_10725 ENOG4105IW6 Carbamoyltransferase HVZ88_10730 ENOG4107RCH Diaminopropionate ammonia-lyase HVZ88_10735 ENOG4107S4Y M20 DapE family protein YgeY HVZ88_10745 ENOG4105C5B carbamate kinase HVZ88_10750 ENOG4107P0T Selenium-dependent molybdenum hydroxylase system protein, YqeB family HVZ88_10755 ENOG4105MJ6 selenium-dependent hydroxylase accessory protein YqeC HVZ88_10760 ENOG4105MFX 4-diphosphocytidyl-2c-methyl-d-erythritol synthase HVZ88_10765 ENOG4105BZ8 glutamate synthase HVZ88_10770 ENOG4107UUR Chlorohydrolase aminohydrolase HVZ88_10775 ENOG410873Y FAD binding domain in molybdopterin dehydrogenase HVZ88_10780 ENOG4105C7W Xanthine dehydrogenase HVZ88_10785 ENOG4105C2W permease HVZ88_10790 ENOG4107QUY Guanine deaminase HVZ88_10795 ENOG4105C7N Xanthine uracil vitamin C permease HVZ88_10800 ENOG4108R8B oxidoreductase Fe-S subunit HVZ88_10805 ENOG4105C2W permease HVZ88_10825 ENOG4105CRK lysyL-tRNA synthetase HVZ88_10835 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) HVZ88_10840 ENOG4105T95 Thiol disulfide interChange protein HVZ88_10845 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HVZ88_10850 ENOG41071R3 Low-potential electron donor to a number of redox enzymes (By similarity) HVZ88_10855 ENOG4108YDB Toxic component of a toxin-antitoxin (TA) module. Overexpression leads to growth arrest after 5 hours, with initial elongation of cells, followed by swelling. The toxic effects are abrogated by coexpression with antitoxin CptB. Interacts with cytoskeletal proteins FtsZ and MreB HVZ88_10860 ENOG4105Y75 tpr repeat protein HVZ88_10870 ENOG4108UT2 hemolysin iii HVZ88_10875 ENOG4105N5Z UPF0267 protein HVZ88_10880 ENOG4105CS2 ec 3.2.1.21 HVZ88_10905 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family HVZ88_10910 ENOG4105D0A hydroxylase HVZ88_10915 ENOG4107RAQ aminopeptidase HVZ88_10935 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase HVZ88_10945 ENOG4108JQ1 Dehydrogenase HVZ88_10965 ENOG4105D5P Methylmalonyl-coA mutase HVZ88_10970 ENOG4105DJT lAO AO transport system ATPase HVZ88_10975 ENOG4108M7F enoyl-CoA hydratase isomerase HVZ88_10980 ENOG4105CYC Transferase HVZ88_10985 ENOG4105DEQ transcriptional regulator HVZ88_10990 ENOG4105MPN Membrane HVZ88_10995 ENOG4108ZUB Lysine exporter protein (Lyse ygga) HVZ88_11000 ENOG4105D64 Mechanosensitive ion channel HVZ88_11005 ENOG4105D2N Aldolase HVZ88_11020 ENOG4107Z1W Fructose transport system kinase HVZ88_11025 ENOG4108R4K DNA-binding, transcriptional regulator HVZ88_11030 ENOG4108Q8A Fructose-1,6-bisphosphatase HVZ88_11035 ENOG4105DXH Alcohol dehydrogenase zinc-binding domain protein HVZ88_11040 ENOG4105CTS PTS system mannitol-specific HVZ88_11045 ENOG4108X7Y Mannitol-specific cryptic phosphotransferase enzyme iia HVZ88_11050 ENOG4105CV1 Transketolase (EC 2.2.1.1) HVZ88_11055 ENOG4108K0D peptidase, M48 HVZ88_11065 ENOG4105DP5 Catalyzes the biosynthesis of agmatine from arginine (By similarity) HVZ88_11085 ENOG4107QNK )-transporter HVZ88_11095 ENOG4105RWS endonuclease I HVZ88_11100 ENOG4105QF0 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) HVZ88_11105 ENOG4105D7Z glutathione synthase HVZ88_11120 ENOG4105CZX twitching motility protein HVZ88_11125 ENOG4105DFA alanine racemase domain protein HVZ88_11130 ENOG4108VIA integral membrane protein HVZ88_11140 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) HVZ88_11145 ENOG4105CSA Coproporphyrinogen iii oxidase HVZ88_11150 ENOG4106MH3 alpha helix chain HVZ88_11155 ENOG4105HDK L-asparaginase HVZ88_11160 ENOG4105K33 Periplasmic Protein HVZ88_11165 ENOG41090ED Protein with unknown function (DUF469) HVZ88_11175 ENOG4105CEN a g-specific adenine glycosylase HVZ88_11190 ENOG4105EAA nucleoside HVZ88_11195 ENOG4105CXN decarboxylase HVZ88_11200 ENOG4108UQV Membrane HVZ88_11210 ENOG4105DFP Integrase HVZ88_11215 ENOG4105EKQ RNA-directed DNA polymerase HVZ88_11225 ENOG4105Z68 AraC Family Transcriptional Regulator HVZ88_11235 ENOG4105BZU Histidine kinase HVZ88_11250 ENOG4108SER Transposase HVZ88_11255 ENOG4105DPW Major facilitator superfamily MFS_1 HVZ88_11260 ENOG4105DIJ Phosphoethanolamine transferase HVZ88_11290 ENOG4105T40 surface antigen msp4 family protein HVZ88_11335 ENOG4108SAU DNA-binding protein H-ns HVZ88_11355 ENOG4108YXQ IS66 Orf2 family protein HVZ88_11375 ENOG4105NI8 Cytosine-specific methyltransferase HVZ88_11410 ENOG4105UPP uncharacterized protein ydcA HVZ88_11495 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit HVZ88_11505 ENOG4105CDV Ompa motb domain protein HVZ88_11585 ENOG4105TS0 gtp-binding protein HVZ88_11590 ENOG4108KZE transcriptional regulator HVZ88_11605 ENOG4106H6R UPF0380 protein HVZ88_11610 ENOG4105MFG Antirestriction protein HVZ88_11615 ENOG4108YGG dna repair protein HVZ88_11625 ENOG4105MAW Antitoxin component of a toxin-antitoxin (TA) module. Labile antitoxin that counteracts the effect of the CbtA (YeeV) toxin. It does not bind to the cognate toxin but instead binds to MreB and FtsZ (the toxin targets), enhancing their polymerization by forming higher-order bundles HVZ88_11650 ENOG4105X54 addiction module antidote protein HVZ88_11670 ENOG4108SF5 RNA Polymerase HVZ88_11675 ENOG4108S3W Anti-feci sigma factor, fecr HVZ88_11680 ENOG4105GAV receptor HVZ88_11685 ENOG4108HUF Transporter HVZ88_11690 ENOG4105DQ5 transport system permease protein HVZ88_11695 ENOG4108IHU transport system permease protein HVZ88_11700 ENOG4105E0A ABC, transporter HVZ88_11730 ENOG4105C94 Transporter HVZ88_11760 ENOG4105NWR lipid A biosynthesis (Kdo)2-(Lauroyl)-lipid IVA acyltransferase HVZ88_11765 ENOG4108MJ5 VirK protein HVZ88_11770 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) HVZ88_11775 ENOG4107BJW polysaccharide deacetylase HVZ88_11790 ENOG4105D5Q Arginine ornithine antiporter HVZ88_11795 ENOG4105CXN decarboxylase HVZ88_11800 ENOG4105D5Q Arginine ornithine antiporter HVZ88_11850 ENOG4105DAA L-lactate HVZ88_11855 ENOG4107QP3 malate synthase g HVZ88_11860 ENOG4108ZJF Glcg protein HVZ88_11865 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) HVZ88_11870 ENOG4105EU8 FAD linked oxidase domain protein HVZ88_11875 ENOG4105CQB FAD linked oxidase domain protein HVZ88_11880 ENOG4108KWP DNA-binding transcriptional regulator GlcC HVZ88_11890 ENOG4107RCI amp-dependent synthetase and ligase HVZ88_11900 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) HVZ88_11905 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) HVZ88_11915 ENOG4108M8S permease YjgP YjgQ family protein HVZ88_11920 ENOG4108UUE Transcriptional regulator HVZ88_11935 ENOG4106FPV ATP-binding protein YghR HVZ88_11940 ENOG4108NDC ATP-binding protein yghS HVZ88_11945 ENOG4108GH0 ATP-binding protein yghT HVZ88_11955 ENOG4106032 Glutathionylspermidine synthase HVZ88_11960 ENOG4105CYM Glutathione S-transferase HVZ88_11965 ENOG41082MF Hydrogenase assembly chaperone hypC hupF HVZ88_11975 ENOG4108WGS hydrogenase 2-specific chaperone HVZ88_11980 ENOG4108USZ hydrogenase HVZ88_11985 ENOG4105DPX Hydrogenase, large subunit HVZ88_11990 ENOG4105CJ5 hydrogenase 2 b cytochrome subunit HVZ88_11995 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein HVZ88_12000 ENOG4105E3S small subunit HVZ88_12005 ENOG410900S Protein of unknown function (DUF2623) HVZ88_12015 ENOG4105CPC Aldo Keto reductase HVZ88_12025 ENOG4105CYX Short-chain dehydrogenase reductase Sdr HVZ88_12030 ENOG4108ZZF transport protein (ExbD) HVZ88_12035 ENOG4105CWK Biopolymer transport protein, ExbB HVZ88_12040 ENOG4105C28 cystathionine HVZ88_12045 ENOG4108K81 inner membrane protein YghB HVZ88_12050 ENOG4105CF7 AraC family transcriptional regulator HVZ88_12055 ENOG4108I6A alcohol dehydrogenase HVZ88_12060 ENOG4105CV8 reductase HVZ88_12065 ENOG4105ZKC Conserved Protein HVZ88_12075 ENOG4105CCT upf0313 protein HVZ88_12080 ENOG4107TZ2 Cell division protein that is required for growth during stress conditions. May be involved in protecting or stabilizing the divisomal assembly under conditions of stress (By similarity) HVZ88_12085 ENOG4107S7E 1-acyl-sn-glycerol-3-phosphate acyltransferase HVZ88_12090 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HVZ88_12095 ENOG4108J59 Extracellular solute-binding protein, family 5 HVZ88_12100 ENOG4105WJ3 XRE family Transcriptional regulator HVZ88_12105 ENOG4105RT5 Toxic component of a toxin-antitoxin (TA) module. An mRNA interferase which has been reported to be translation- independent (PubMed 19690171, PubMed 19943910) and translation- dependent (PubMed 20041169). Cleavage has been reported to occur on either side of G in the sequence GCU (PubMed 19690171) but also after C in GC(A U) sequences (PubMed 19943910). There are only 14 genes in E.coli W3110 (and probably also MG1655) that do not have a GCU sequence and thus are resistant to the mRNA interferase activity. Overexpression causes cessation of cell growth and inhibits cell proliferation via inhibition of translation as well as increasing persister cell formation HVZ88_12110 ENOG4105F4I Transcriptional regulator HVZ88_12115 ENOG4105H4F exported protein HVZ88_12120 ENOG4105XJC Two component transcriptional regulator (Winged helix family HVZ88_12125 ENOG4105DHQ Histidine kinase HVZ88_12130 ENOG4107DEU Inner membrane protein YgiZ HVZ88_12135 ENOG4105NF4 modulator of drug activity HVZ88_12140 ENOG4105VRH Antibiotic biosynthesis monooxygenase HVZ88_12145 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HVZ88_12150 ENOG4105IPS esterase HVZ88_12155 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) HVZ88_12160 ENOG4108SX3 cytoplasmic protein HVZ88_12165 ENOG41087AY ADP-Ribose pyrophosphatase HVZ88_12170 ENOG4105DFG type I secretion outer membrane protein HVZ88_12180 ENOG4106032 Glutathionylspermidine synthase HVZ88_12185 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b HVZ88_12205 ENOG4105W0Z cytoplasmic protein HVZ88_12210 ENOG4105H8W Fimbrial protein HVZ88_12220 ENOG4108TTM chaperone HVZ88_12225 ENOG4108MY7 Fimbrial HVZ88_12235 ENOG4105PV3 Inner membrane protein yqiJ HVZ88_12240 ENOG4107S78 Band 7 protein HVZ88_12260 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) HVZ88_12265 ENOG4105I7R Adenylate cyclase HVZ88_12270 ENOG4106MWK domain protein HVZ88_12285 ENOG4107ZVW dihydroneopterin aldolase HVZ88_12295 ENOG4105EJC lysr family transcriptional regulator HVZ88_12300 ENOG4106DSS Tartrate dehydratase subunit alpha HVZ88_12305 ENOG4107GFK fumarate HVZ88_12310 ENOG4107QPK )-transporter HVZ88_12315 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) HVZ88_12325 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) HVZ88_12330 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HVZ88_12365 ENOG4105MAW Antitoxin component of a toxin-antitoxin (TA) module. Labile antitoxin that counteracts the effect of the CbtA (YeeV) toxin. It does not bind to the cognate toxin but instead binds to MreB and FtsZ (the toxin targets), enhancing their polymerization by forming higher-order bundles HVZ88_12375 ENOG4108YGG dna repair protein HVZ88_12380 ENOG4105MFG Antirestriction protein HVZ88_12385 ENOG4106H6R UPF0380 protein HVZ88_12430 ENOG4108YIV HVZ88_12435 ENOG4108F5E vimentin HVZ88_12440 ENOG4105F4K antigen 43 HVZ88_12535 ENOG4105CKT filamentous hemagglutinin HVZ88_12545 ENOG4105D5K Hemolysin activator protein HVZ88_12565 ENOG4105C0D helicase HVZ88_12580 ENOG4105JXR Protein of unknown function (DUF3296) HVZ88_12585 ENOG410693A DNA-binding protein HVZ88_12615 ENOG4105Q26 Siderophore-interacting protein HVZ88_12620 ENOG4105NTW Transcriptional regulator HVZ88_12625 ENOG4107RHT methyl-accepting chemotaxis sensory transducer with Pas Pac sensor HVZ88_12630 ENOG4105C8Y Acetylornithine aminotransferase HVZ88_12635 ENOG4108Y51 tRNA-binding protein HVZ88_12640 ENOG4105CQ4 Transcriptional regulator HVZ88_12645 ENOG4105CNT hydrolase family 2 HVZ88_12650 ENOG4105FK9 beta-D-galactosidase beta subunit HVZ88_12655 ENOG4105E5D amino acid HVZ88_12660 ENOG4107W6W Conserved Protein HVZ88_12665 ENOG4107WCA isomerase HVZ88_12670 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HVZ88_12675 ENOG4108Z3N Transcriptional regulator HVZ88_12680 ENOG4105R48 this blockage is overcome by subsequent expression of antitoxin HigA. Overexpression causes cleavage of a number of mRNAs in a translation-dependent fashion, suggesting this is an mRNA interferase HVZ88_12685 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) HVZ88_12690 ENOG4108VKG metal-dependent hydrolase HVZ88_12695 ENOG4108UB4 uncharacterized protein ygjQ HVZ88_12700 ENOG4105EE0 oxidoreductase HVZ88_12705 ENOG4105DU1 integral membrane protein, terc HVZ88_12710 ENOG4107QV7 Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system) (By similarity) HVZ88_12715 ENOG4105P66 Membrane HVZ88_12720 ENOG4105CTX dehydratase HVZ88_12730 ENOG4105DPW Major facilitator superfamily MFS_1 HVZ88_12735 ENOG4107YCY Transcriptional regulator HVZ88_12740 ENOG4106W5V Membrane HVZ88_12745 ENOG4105IYR Modulates the activity of the EnvZ OmpR two-component regulatory system, probably by directly modulating EnvZ enzymatic activity and increasing stability of phosphorylated OmpR (By similarity) HVZ88_12750 ENOG4105WAY exported protein HVZ88_12755 ENOG4105NE1 Conserved Protein HVZ88_12760 ENOG41090KG Inner membrane protein YqjE HVZ88_12765 ENOG4105YJD HVZ88_12770 ENOG4108VBZ doxx family HVZ88_12775 ENOG4105CHF Glutathione S-transferase HVZ88_12795 ENOG4105KAF membrAne HVZ88_12800 ENOG4105CWB LysR family transcriptional Regulator HVZ88_12805 ENOG4108CNN domain protein HVZ88_12810 ENOG4106D80 Uncharacterized protein YhaL HVZ88_12815 ENOG4105CEM UPF0597 protein HVZ88_12820 ENOG4105C44 Serine transporter HVZ88_12825 ENOG4105EJQ L-serine dehydratase HVZ88_12830 ENOG4105KME endoribonuclease L-psp HVZ88_12835 ENOG4105C6N Formate acetyltransferase HVZ88_12840 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) HVZ88_12850 ENOG4105C7B Threonine dehydratase HVZ88_12855 ENOG410811B TRANSCRIPTIONal HVZ88_12880 ENOG4105BZW Glycerate kinase HVZ88_12885 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase HVZ88_12895 ENOG4105DJB Major Facilitator Superfamily HVZ88_12900 ENOG4105CTX dehydratase HVZ88_12905 ENOG4105ZEG Suppressor protein HVZ88_12910 ENOG4108R8Z these effects are overcome by concomitant expression of antitoxin SohA (PrlF). Massive overexpression is toxic. Unlike most other characterized TA systems degrades rRNA, and co-folding of the proteins is necessary in vitro for inhibition of the RNase activity. It is not known if it has any sequence-specificity. Acts as a transcription factor. The YhaV PrlF complex binds the prlF-yhaV operon, probably negatively regulating its expression HVZ88_12915 ENOG4105E98 transcriptional regulator DeoR family HVZ88_12920 ENOG4105C6Q that is required for full activity and stability of the Y subunit. Could have a chaperone-like function for the proper and stable folding of HVZ88_12925 ENOG4108RG5 PTS system N-acetylgalactosamine-specific transporter subunit IIB HVZ88_12935 ENOG4105F3R pts system mannose fructose sorbose family iid HVZ88_12940 ENOG4108YTN IIa component HVZ88_12945 ENOG4105CE4 GlcNAc 6-P deacetylase HVZ88_12950 ENOG4105E70 isomerase HVZ88_12960 ENOG4108UZY PTS System HVZ88_12965 ENOG4105ETZ PTS System HVZ88_12970 ENOG4105F3R pts system mannose fructose sorbose family iid HVZ88_12975 ENOG4106HBN Galactosamine-6-phosphate isomerase HVZ88_12980 ENOG4105Q10 Fimbrial-like protein HVZ88_12985 ENOG4108VCD Chaperone HVZ88_12990 ENOG4105CW0 outer membrane usher protein HVZ88_12995 ENOG4105I74 Fimbrial protein HVZ88_13000 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) HVZ88_13005 ENOG4105E1C Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1A (PBP1a) (By similarity) HVZ88_13010 ENOG41082RQ UPF0102 protein HVZ88_13020 ENOG4105W4M Transport-associated protein HVZ88_13025 ENOG4107S21 permease HVZ88_13030 ENOG4105K4T epimerase HVZ88_13035 ENOG4107R7Y intracellular protease Pfpi family HVZ88_13045 ENOG41082IR Excinuclease ABC C subunit domain protein HVZ88_13050 ENOG4108YYD acetyltransferase HVZ88_13070 ENOG4105DEN Luciferase family HVZ88_13075 ENOG4105CIC tryptophan-specific transport protein HVZ88_13080 ENOG4105C1J atp-dependent rna helicase HVZ88_13120 ENOG4105CHV Transcription elongation factor NusA HVZ88_13140 ENOG4105DIJ Phosphoethanolamine transferase HVZ88_13150 ENOG4105NTZ Preprotein translocase subunit SecG HVZ88_13160 ENOG4105EEI dihydropteroate synthase HVZ88_13165 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) HVZ88_13175 ENOG4105HBR Rna-binding protein HVZ88_13180 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) HVZ88_13185 ENOG4106HRJ d-alanyl-d-alanine carboxypeptidase HVZ88_13190 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control HVZ88_13195 ENOG4105QYV Membrane HVZ88_13210 ENOG4105EAH synthase HVZ88_13215 ENOG4105HVQ Regulatory factor of maltose metabolism HVZ88_13225 ENOG4105VFK BolA family HVZ88_13230 ENOG4105UE2 Part of the ABC transporter complex MlaFEDB that actively prevents phospholipid accumulation at the cell surface. Probably maintains lipid asymmetry in the outer membrane by retrograde trafficking of phospholipids from the outer membrane to the inner membrane HVZ88_13235 ENOG4105E3I toluene tolerance HVZ88_13240 ENOG4107PE3 Mammalian cell entry related domain protein HVZ88_13245 ENOG4105CY3 ABC transporter, permease HVZ88_13250 ENOG4105DHJ ABC, transporter HVZ88_13255 ENOG4105FEU K -dependent Na -Ca exchanger HVZ88_13260 ENOG4105C2X Arabinose 5-phosphate isomerase HVZ88_13265 ENOG4108Z4R 3-deoxy-d-manno-octulosonate 8-phosphate phosphatase HVZ88_13270 ENOG4108P1K Required for the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane (By similarity) HVZ88_13275 ENOG4105WI0 lipopolysaccharide transport periplasmic protein lptA HVZ88_13280 ENOG4108IUZ ABC transporter HVZ88_13285 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HVZ88_13290 ENOG41080QH sigma 54 modulation protein ribosomal protein S30EA HVZ88_13295 ENOG4107RM2 PTS IIA-like nitrogen-regulatory protein PtsN HVZ88_13305 ENOG41080Z8 PHOSPHOCARRIER protein HVZ88_13310 ENOG4108NIH transferase activity, transferring phosphorus-containing groups HVZ88_13320 ENOG4108556 Isoprenoid biosynthesis protein with amidotransferase-like domain HVZ88_13325 ENOG4105BZU Histidine kinase HVZ88_13330 ENOG4105N5T Radical SAM Protein HVZ88_13335 ENOG4105CBC glutamate synthase HVZ88_13340 ENOG4105BZ8 glutamate synthase HVZ88_13345 ENOG4106AJS Involved in induction of the so-called NTR enzymes in response to nitrogen deprivation, as well as in glutamate biosynthesis. May mediate the glutamate-dependent repression of the GLT operon HVZ88_13350 ENOG4108S1B Periplasmic chaperone protein HVZ88_13375 ENOG4105UMR response to DNA damage stimulus HVZ88_13390 ENOG4105DFS Conserved Protein HVZ88_13395 ENOG4108R66 Conserved Protein HVZ88_13400 ENOG41061DF Catalyzes the phosphorylation of N-acetylmannosamine (ManNAc) to ManNAc-6-P (By similarity) HVZ88_13410 ENOG4105JHE Major Facilitator Superfamily HVZ88_13420 ENOG4108QBF Transcriptional regulator HVZ88_13425 ENOG4105CEE C4-dicarboxylate transporter HVZ88_13430 ENOG4105KB2 stringent starvation protein b HVZ88_13435 ENOG4107MKT Stringent starvation protein a HVZ88_13450 ENOG4105D6Z AFG1 family ATPase HVZ88_13455 ENOG4108W2Q Cytochrome d ubiquinol oxidase subunit III HVZ88_13460 ENOG4105C0H protease HVZ88_13465 ENOG4105C0H protease HVZ88_13480 ENOG4105RID UPF0379 protein yhcN HVZ88_13485 ENOG4105UNR (Barnase) inhibitor HVZ88_13500 ENOG4105ZQC membrane protein AaeX HVZ88_13505 ENOG4105CR8 Transcriptional regulator HVZ88_13510 ENOG4105D1U peptidase U62 modulator of DNA gyrase HVZ88_13515 ENOG4105QD6 exported protein HVZ88_13520 ENOG4105C03 ribonuclease HVZ88_13525 ENOG4108Z03 MAF-like protein HVZ88_13530 ENOG4105VQ7 Rod shape-determining protein MreD HVZ88_13535 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) HVZ88_13545 ENOG41062P1 Diguanylate cyclase phosphodiesterase HVZ88_13550 ENOG4105D3Z quinone oxidoreductase, yhdh yhfp family HVZ88_13555 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein HVZ88_13560 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase HVZ88_13565 ENOG4105RG0 Membrane HVZ88_13570 ENOG4108IA2 Sodium pantothenate symporter HVZ88_13580 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) HVZ88_13590 ENOG4105CEC DNA methylase N-4 N-6 HVZ88_13595 ENOG41061ME transport protein HVZ88_13600 ENOG4108XG4 DNA-binding transcriptional regulator HVZ88_13605 ENOG4105C1P efflux transporter, rnd family, mfp subunit HVZ88_13610 ENOG4105BZS acriflavin resistance protein HVZ88_13615 ENOG4105XCM membrane LIPOPROTEIN HVZ88_13625 ENOG4105EZ7 amino acid ABC transporter HVZ88_13630 ENOG4105DRP amino acid AbC transporter HVZ88_13635 ENOG4105CDA abc transporter atp-binding protein HVZ88_13675 ENOG4108Z0R Transferase HVZ88_13680 ENOG4105SG3 Protein of unknown function (DUF1488) HVZ88_13695 ENOG4108WI1 Dna topoisomerase HVZ88_13705 ENOG4105C79 DNA protecting protein DprA HVZ88_13725 ENOG4105C1A potassium transporter peripheral membrane HVZ88_13735 ENOG4105VCN Rescues the ribosomes stalled at the 3' end of non-stop mRNAs. May induce hydrolysis of the ribosome-bound peptidyl-tRNA. This activity is crucial when the stalled ribosome can not be rescued by the SsrA(tmRNA)-SmpB quality control system HVZ88_13740 ENOG4105W1Y Transcriptional regulator HVZ88_13745 ENOG4105VTS DnaJ-like, subfamily C HVZ88_13775 ENOG41067V7 50S ribosomal protein L36 HVZ88_13780 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) HVZ88_13825 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) HVZ88_13870 ENOG41080KG One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) HVZ88_13890 ENOG4107ACA Calcium-binding protein required for initiation of chromosome replication HVZ88_13895 ENOG410899B May play a regulatory role under conditions of derepressed gsp gene expression HVZ88_13900 ENOG4107KSE General secretion pathway protein C HVZ88_13905 ENOG4105GVR general secretion pathway protein D HVZ88_13910 ENOG4107QHF type ii secretion system protein e HVZ88_13915 ENOG4105D7Q type ii secretion system HVZ88_13920 ENOG4108VAU general secretion pathway protein G HVZ88_13925 ENOG41069X0 general secretion pathway protein h HVZ88_13940 ENOG4105R04 type II secretion system protein K HVZ88_13945 ENOG41063JA Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins (By similarity) HVZ88_13955 ENOG4105EHH Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue (By similarity) HVZ88_13960 ENOG4108UQY Iron-storage protein HVZ88_13965 ENOG4105W53 bacterioferritin-associated ferredoxin HVZ88_13970 ENOG4108NNZ chitinase HVZ88_13995 ENOG4105YKK Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions (By similarity) HVZ88_14000 ENOG4108ZKU Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions (By similarity) HVZ88_14005 ENOG4108ZAT Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE (By similarity) HVZ88_14010 ENOG4105WWK YheO domain protein HVZ88_14015 ENOG4108V1T peptidylprolyl cis-trans isomerase HVZ88_14025 ENOG4108YZY peptidylprolyl cis-trans isomerase HVZ88_14030 ENOG4105VKU nucleicacid-binding protein HVZ88_14035 ENOG4105CKD glutathione-regulated potassium-efflux system protein HVZ88_14045 ENOG4105C5H ABC transporter HVZ88_14050 ENOG4105DNZ Alpha Beta Hydrolase HVZ88_14060 ENOG4105CJE phosphoribulokinase (EC 2.7.1.19) HVZ88_14065 ENOG4108UKZ OsmC family HVZ88_14075 ENOG410613R integral membrane protein, YccS YhfK family HVZ88_14080 ENOG4105C8Y Acetylornithine aminotransferase HVZ88_14085 ENOG4105DDQ anthranilate synthase HVZ88_14090 ENOG4105MZU cell filamentation protein HVZ88_14100 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) HVZ88_14110 ENOG4107QZF nitrite reductase NADPH large subunit HVZ88_14115 ENOG4105WZK nitrite reductase NADPH small subunit HVZ88_14120 ENOG4107V9H nitrite transporter HVZ88_14130 ENOG4105VYH HVZ88_14135 ENOG4107QHQ amino acid HVZ88_14140 ENOG4107R1S catalyzes the conversion of fructoselysine 6-phosphate to glucose 6-phosphate and lysine HVZ88_14145 ENOG4107Y0V Not clear, may be involved in an isomerization step HVZ88_14150 ENOG4108KPW sugar kinase HVZ88_14155 ENOG4105FDP GntR family transcriptional regulator HVZ88_14160 ENOG4106PKC pyridoxal phosphate binding HVZ88_14165 ENOG4106M0N transport system permease protein HVZ88_14170 ENOG4105MUZ Protein of unknown function DUF2620 HVZ88_14175 ENOG41080QX K07048 phosphotriesterase-related protein HVZ88_14180 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) HVZ88_14195 ENOG4108M21 HVZ88_14200 ENOG4105C31 Tryptophanyl-tRNA synthetase HVZ88_14205 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) HVZ88_14210 ENOG4105DJV ribulose-phosphate 3-epimerase HVZ88_14215 ENOG4105DFE Dna adenine methylase HVZ88_14220 ENOG4105EGB membrane protein DamX HVZ88_14225 ENOG4105D49 3-dehydroquinate synthase HVZ88_14240 ENOG4105ITY Required for the use of extracellular DNA as a nutrient HVZ88_14245 ENOG4105XPX DNA utilization protein HofO HVZ88_14250 ENOG41065NF Fimbrial assembly family protein HVZ88_14255 ENOG4108U1Q Pilus assembly protein HVZ88_14260 ENOG4108JQC penicillin-binding protein 1A HVZ88_14265 ENOG4107RK2 ADP-ribose diphosphatase NudE HVZ88_14270 ENOG4105DQY intracellular growth attenuator HVZ88_14275 ENOG4107Y3D HAD-superfamily hydrolase subfamily IA variant 3 HVZ88_14280 ENOG4105VEJ Heat shock protein HVZ88_14290 ENOG4108MAJ Membrane HVZ88_14300 ENOG4105E0F Histidine kinase HVZ88_14310 ENOG4108RRZ Transcription elongation factor GreB HVZ88_14315 ENOG4105BZM domain protein HVZ88_14320 ENOG4105XFK Ferrous iron transport protein A HVZ88_14325 ENOG4105CE1 Ferrous iron transport protein b HVZ88_14335 ENOG4105DNE Transposase HVZ88_14340 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) HVZ88_14345 ENOG4105MJ2 Competence protein HVZ88_14355 ENOG4105C6Z Gluconate HVZ88_14360 ENOG4107RTM 4-alpha-glucanotransferase (EC 2.4.1.25) HVZ88_14365 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) HVZ88_14375 ENOG4105CKX Catalyzes the conversion of 3'-phosphate to a 2',3'- cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps (A) adenylation of the enzyme by ATP HVZ88_14380 ENOG4105E0Y RtcB Protein HVZ88_14385 ENOG4105CYB regulatoR HVZ88_14390 ENOG4105E98 transcriptional regulator DeoR family HVZ88_14405 ENOG4105C6V Glycerol-3-phosphate dehydrogenase HVZ88_14415 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) HVZ88_14440 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) HVZ88_14445 ENOG41076UM multiple antibiotic resistance (MarC)-related protein HVZ88_14450 ENOG4105C6Z Gluconate HVZ88_14455 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family HVZ88_14460 ENOG4105DIQ Transcriptional regulator HVZ88_14465 ENOG4105C2I pirin domain protein HVZ88_14470 ENOG4105D9R oxidoreductase HVZ88_14475 ENOG4105WCN acetyltransferase HVZ88_14480 ENOG4105GMB type VI secretion system effector, hcp1 family HVZ88_14495 ENOG4106FA4 HVZ88_14500 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) HVZ88_14505 ENOG4105WC8 Conserved Protein HVZ88_14510 ENOG4107T6V glycerophosphoryl diester phosphodiesterase HVZ88_14515 ENOG4108IJ9 (ABC) transporter HVZ88_14520 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component HVZ88_14525 ENOG4105E4X binding-protein-dependent transport systems inner membrane Component HVZ88_14530 ENOG4105BZ7 extracellular solute-binding protein family 1 HVZ88_14535 ENOG4108IV0 ABC, transporter HVZ88_14540 ENOG4105C0Z ABC transporter HVZ88_14545 ENOG4105CF8 branched-chain amino acid ABC transporter, permease HVZ88_14550 ENOG4105C32 Amino acid ABC transporter (Permease) HVZ88_14555 ENOG4105CP9 extracellular ligand-binding receptor HVZ88_14560 ENOG4105U59 -acetyltransferase HVZ88_14565 ENOG4105CP9 extracellular ligand-binding receptor HVZ88_14570 ENOG4105DEK Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HVZ88_14575 ENOG4105CRP Part of the ABC transporter FtsEX involved in HVZ88_14580 ENOG4105CAK Cell division ATP-binding protein ftsE HVZ88_14585 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) HVZ88_14590 ENOG4106H78 methyltransferase HVZ88_14595 ENOG4105MG3 Membrane HVZ88_14605 ENOG4107FS9 Membrane HVZ88_14610 ENOG4105C59 p-type ATPase HVZ88_14620 ENOG4105EX9 Membrane HVZ88_14625 ENOG4108W1V Lipoprotein HVZ88_14630 ENOG4105F9N Major Facilitator Superfamily HVZ88_14635 ENOG4105DSF transport protein HVZ88_14640 ENOG4107YAK holo-(acyl carrier protein) synthase 2 HVZ88_14645 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein HVZ88_14650 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HVZ88_14655 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HVZ88_14660 ENOG4106665 Part of the ABC transporter complex NikABCDE involved in nickel import. Responsible for energy coupling to the transport system (By similarity) HVZ88_14665 ENOG4105EFJ Part of the ABC transporter complex NikABCDE involved in nickel import. Responsible for energy coupling to the transport system (By similarity) HVZ88_14675 ENOG4105CNA YD repeat protein HVZ88_14685 ENOG4105NUP lyase containing HEAT-repeat HVZ88_14690 ENOG410600T transposase HVZ88_14695 ENOG4105CMI transporter HVZ88_14700 ENOG4105CJ1 ABC, transporter HVZ88_14705 ENOG4105D0S secretion protein (HlyD HVZ88_14720 ENOG4107UNS conserved inner membrane protein HVZ88_14725 ENOG4105CBX hi0933 family HVZ88_14730 ENOG4105CJ3 phosphate transporter HVZ88_14745 ENOG4105DUX Transporter HVZ88_14755 ENOG4105DGW oligopeptidase A HVZ88_14760 ENOG4105D6S protein involved in catabolism of external DNA HVZ88_14765 ENOG4105DC8 reductase HVZ88_14775 ENOG4105KBH arsR family transcriptional regulator HVZ88_14780 ENOG4107R5R arsenical pump membrane protein HVZ88_14785 ENOG4105K89 arsenate reductase HVZ88_14795 ENOG4105Y4Z Outer Membrane Lipoprotein HVZ88_14805 ENOG4105KT7 mgtC SapB transporter HVZ88_14810 ENOG4105XXV Acid-resistance protein HVZ88_14815 ENOG41060V2 Acid-resistance protein HVZ88_14820 ENOG4108YK4 Acid-resistance membrane protein HVZ88_14825 ENOG4106WJ0 Regulates the expression of several genes involved in acid resistance. Required for the expression of gadA and gadBC, among others, regardless of media or growth conditions. Binds directly to the 20 bp GAD box found in the control regions of both loci HVZ88_14835 ENOG4105C1P efflux transporter, rnd family, mfp subunit HVZ88_14840 ENOG4105BZS acriflavin resistance protein HVZ88_14850 ENOG4108NKV transcriptional regulator HVZ88_14855 ENOG4105CVK Glutamate decarboxylase HVZ88_14860 ENOG4105CA0 peroxidase HVZ88_14870 ENOG4106S2D Transcriptional regulator HVZ88_14875 ENOG4105CBN LysR family transcriptional regulator HVZ88_14880 ENOG4107H3J ribonuclease HVZ88_14885 ENOG4105CSH Transporter HVZ88_14890 ENOG41066T0 asmA family HVZ88_14895 ENOG4105CMB EAL domain-containing protein HVZ88_14900 ENOG4107SS6 2-dehydro-3-deoxygluconokinase HVZ88_14905 ENOG4105CS0 peptidase HVZ88_14915 ENOG4105BZU Histidine kinase HVZ88_14920 ENOG4105EJG cellulose synthase HVZ88_14930 ENOG4107EEX Cellulose synthase regulator protein HVZ88_14935 ENOG4107QZ7 Cellulose synthase catalytic subunit HVZ88_14945 ENOG4105WQA Cellulose biosynthesis protein BcsF HVZ88_14950 ENOG4105D1V cellulose synthase operon protein YhjU HVZ88_14960 ENOG4105C44 Serine transporter HVZ88_14965 ENOG4108JQ7 (ABC) transporter HVZ88_14970 ENOG4105C3U ABC transporter HVZ88_14975 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HVZ88_14980 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HVZ88_14985 ENOG4105DEF Extracellular solute-binding protein, family 5 HVZ88_14995 ENOG4105DIJ Phosphoethanolamine transferase HVZ88_15000 ENOG4105FCD Major Facilitator HVZ88_15005 ENOG4105EAX Putative lipase HVZ88_15010 ENOG4108R3E Dna-3-methyladenine glycosylase i HVZ88_15015 ENOG4105HNP -acetyltransferase HVZ88_15020 ENOG4107QY8 reductase HVZ88_15025 ENOG4108ZG0 Ompa motb domain protein HVZ88_15030 ENOG4105C5I Dehydrogenase HVZ88_15035 ENOG4106JH6 (LipO)protein HVZ88_15040 ENOG4105MVF Transcriptional regulator HVZ88_15050 ENOG41060TC Hok gef cell toxic protein HVZ88_15070 ENOG4105RGS lipoprotein ysaB HVZ88_15075 ENOG4105MEV Acyl-transferase HVZ88_15080 ENOG4108Z12 YiaAB two helix domain-containing protein HVZ88_15085 ENOG410688U Inner membrane protein yiaB HVZ88_15090 ENOG4105CMG Carbohydrate kinase HVZ88_15095 ENOG4105C93 Xylose Isomerase HVZ88_15100 ENOG4105DFW ABC transporter HVZ88_15105 ENOG4105C2J ABC transporter HVZ88_15110 ENOG4108HWW ABC transporter HVZ88_15115 ENOG4105T16 Transcriptional regulator (AraC family) HVZ88_15120 ENOG4108UR8 BAX protein HVZ88_15125 ENOG4107T9C Alpha amylase catalytic region HVZ88_15130 ENOG4105JKW Valine--pyruvate aminotransferase HVZ88_15135 ENOG4108XIB electron transport protein ysaA HVZ88_15140 ENOG4105J4Q Transcriptional regulator HVZ88_15150 ENOG4108R66 Conserved Protein HVZ88_15155 ENOG4105XDZ Tripartite ATP-independent periplasmic transporter HVZ88_15160 ENOG4105CG6 trap dicarboxylate transporter dctm subunit HVZ88_15165 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit HVZ88_15170 ENOG4105CMG Carbohydrate kinase HVZ88_15175 ENOG4105H6Q decarboxylase HVZ88_15180 ENOG41064BZ L-xylulose 5-phosphate 3-epimerase HVZ88_15185 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase HVZ88_15195 ENOG4105CT4 transporter HVZ88_15205 ENOG4105GNX MltA-interacting MipA family protein HVZ88_15210 ENOG4108Q2M Transcriptional regulator HVZ88_15215 ENOG4105EFX secretion protein, HlyD family HVZ88_15220 ENOG4105KK7 inner membrane protein YiaW HVZ88_15230 ENOG4105C26 Dehydrogenase HVZ88_15235 ENOG4105C0A alcohol dehydrogenase HVZ88_15240 ENOG4105EM7 Selenocysteine-specific translation elongation factor HVZ88_15250 ENOG4108U78 Glutathione S-transferase HVZ88_15255 ENOG4105CNA YD repeat protein HVZ88_15260 ENOG4105NUP lyase containing HEAT-repeat HVZ88_15285 ENOG4105EFX secretion protein, HlyD family HVZ88_15290 ENOG4105FP6 Protein of unknown function (DUF3302) HVZ88_15295 ENOG4105CTS PTS system mannitol-specific HVZ88_15305 ENOG4105E61 Mannitol repressor protein HVZ88_15315 ENOG4108YYI Protein of unknown function (DUF2810) HVZ88_15320 ENOG4108WY4 inner membrane lipoprotein HVZ88_15325 ENOG4105EUR Domain-Containing protein HVZ88_15330 ENOG4105DAA L-lactate HVZ88_15335 ENOG41073TP transcriptional regulator HVZ88_15345 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) HVZ88_15350 ENOG4105D7W serine acetyltransferase HVZ88_15365 ENOG4105VW4 glutaredoxin 3 HVZ88_15370 ENOG4107YZP Rhodanese domain protein HVZ88_15375 ENOG4105CJI Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity) HVZ88_15380 ENOG41063SB peptidase HVZ88_15385 ENOG4105PXI polysaccharide deacetylase HVZ88_15390 ENOG4105K64 Glycosyl transferase, family 2 HVZ88_15395 ENOG4105CPQ Dehydrogenase HVZ88_15400 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) HVZ88_15405 ENOG4108SEH involved in lipopolysaccharide biosynthesis HVZ88_15415 ENOG4105XA0 heptosyltransferase ii HVZ88_15420 ENOG4105D16 lipopolysaccharide heptosyltransferase i HVZ88_15425 ENOG41068PG O-Antigen polymerase HVZ88_15430 ENOG4108XNZ glycosyl transferase HVZ88_15435 ENOG4108QD8 lipopolysaccharide core biosynthesis protein HVZ88_15440 ENOG4108PDR lipopolysaccharide core biosynthesis protein HVZ88_15445 ENOG4105X1N Glycosyl transferase family 8 HVZ88_15450 ENOG4106AH0 Glycosyl Transferase HVZ88_15455 ENOG4107XU6 Glycosyl transferase (Group 1 HVZ88_15460 ENOG410650X lipopolysaccharide core region biosynthetic process HVZ88_15465 ENOG4107543 (lipo)polysaccharide HVZ88_15470 ENOG4107RJ7 Glycosyl transferase (Group 1 HVZ88_15475 ENOG4105DKP glycosyl transferase, family 9 HVZ88_15480 ENOG4105D8A 3-Deoxy-D-manno-octulosonic-acid transferase HVZ88_15500 ENOG4105KDC 50s ribosomal protein l28 HVZ88_15510 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase HVZ88_15515 ENOG4108Z1K This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) HVZ88_15535 ENOG4105DSJ YicC domain protein HVZ88_15540 ENOG4105F5P DNA-damage-inducible protein d HVZ88_15545 ENOG4105EN6 Membrane HVZ88_15550 ENOG410649J Catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction (By similarity) HVZ88_15555 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) HVZ88_15565 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) HVZ88_15570 ENOG4105FE8 tRNA (Guanosine-2'-O-)-methyltransferase HVZ88_15575 ENOG4105CB5 ATP-dependent DNA helicase recG HVZ88_15580 ENOG4105D6U Sodium Glutamate Symporter HVZ88_15585 ENOG4105C2W permease HVZ88_15590 ENOG4105JV1 AsmA family HVZ88_15595 ENOG4105CJQ hydrolase, family 31 HVZ88_15600 ENOG4105CT4 transporter HVZ88_15610 ENOG4105DFP Integrase HVZ88_15620 ENOG4105DIJ Phosphoethanolamine transferase HVZ88_15645 ENOG4105T40 surface antigen msp4 family protein HVZ88_15665 ENOG4105C3X it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity) HVZ88_15670 ENOG4107XZC Restriction modification system DNA (Specificity HVZ88_15680 ENOG4107SCJ type I restriction enzyme EcoKI subunit R HVZ88_15695 ENOG4105M03 Domain of unknown function (DUF955) HVZ88_15810 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit HVZ88_15820 ENOG4105CDV Ompa motb domain protein HVZ88_15885 ENOG4105DQ6 Transposase HVZ88_15895 ENOG4105DQ6 Transposase HVZ88_15900 ENOG4105IYK transposase HVZ88_15910 ENOG4108ZK4 sdia-regulated domain-containing protein HVZ88_15920 ENOG4105E5H Transposase HVZ88_15925 ENOG4108YXQ IS66 Orf2 family protein HVZ88_15960 ENOG4108V1T peptidylprolyl cis-trans isomerase HVZ88_15965 ENOG4108SER Transposase HVZ88_15980 ENOG4106CXJ Residues 2 to 179 of 179 are 100.00 pct identical to residues 1 to 178 of 178 from SwissProt.40 sp P42190 PAPK_ECOLI PROTEIN PAPK PRECURSOR HVZ88_15990 ENOG4106P2F Pfam:Pili_assembly_C HVZ88_15995 ENOG4106PG1 outer membrane usher protein HVZ88_16000 ENOG4108ZJG MrfB protein HVZ88_16005 ENOG4105HMV Fimbrial protein HVZ88_16085 ENOG4105TS0 gtp-binding protein HVZ88_16100 ENOG4106H6R UPF0380 protein HVZ88_16105 ENOG4106549 Antirestriction protein HVZ88_16110 ENOG4108YGG dna repair protein HVZ88_16120 ENOG4105MAW Antitoxin component of a toxin-antitoxin (TA) module. Labile antitoxin that counteracts the effect of the CbtA (YeeV) toxin. It does not bind to the cognate toxin but instead binds to MreB and FtsZ (the toxin targets), enhancing their polymerization by forming higher-order bundles HVZ88_16150 ENOG4105S8Q sugar efflux transporter HVZ88_16155 ENOG4108UZ3 Transporter HVZ88_16160 ENOG4105D01 (LipO)protein HVZ88_16165 ENOG4105T8A Uncharacterized protein YicS HVZ88_16175 ENOG4108SAJ Protein of unknown function (DUF1198) HVZ88_16180 ENOG4105C7N Xanthine uracil vitamin C permease HVZ88_16185 ENOG4105CPN adenine deaminase HVZ88_16190 ENOG4105CXY transporter HVZ88_16195 ENOG4105CXY transporter HVZ88_16200 ENOG4105BZU Histidine kinase HVZ88_16205 ENOG4108KX4 response regulator HVZ88_16210 ENOG4105M71 acetolactate synthase 1 regulatory subunit HVZ88_16215 ENOG4105C7K acetolactate synthase HVZ88_16230 ENOG4105E5M Multidrug resistance protein D HVZ88_16235 ENOG4105J13 transcriptional regulator HVZ88_16240 ENOG4105JP4 Inner membrane protein yidG HVZ88_16245 ENOG4105VG5 Membrane HVZ88_16250 ENOG4106DRA Inner membrane protein YidI HVZ88_16255 ENOG4105CBG Sulfatase HVZ88_16260 ENOG4107RUZ Sss sodium solute transporter superfamily HVZ88_16265 ENOG4108AHD Transcriptional regulator HVZ88_16275 ENOG4105CI1 PTS System HVZ88_16280 ENOG4105FDP GntR family transcriptional regulator HVZ88_16300 ENOG4105R2A (LipO)protein HVZ88_16305 ENOG4105D99 atp gtp-binding protein HVZ88_16310 ENOG4107WAP fad NAD(P)-binding domain HVZ88_16315 ENOG4105DJB Major Facilitator Superfamily HVZ88_16325 ENOG4108RTU Aldolase HVZ88_16330 ENOG4105EI3 2-dehydro-3-deoxygalactonokinase EC 2.7.1.58 HVZ88_16335 ENOG4105EMF GntR family transcriptional regulator HVZ88_16340 ENOG410657R replicase EC 2.7 HVZ88_16345 ENOG410667J hydrolase HVZ88_16350 ENOG4105VP5 Bacterial protein of unknown function (DUF937) HVZ88_16355 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HVZ88_16365 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) HVZ88_16380 ENOG4105VG0 50S ribosomal protein l34 HVZ88_16395 ENOG4105DHW Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins HVZ88_16400 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) HVZ88_16415 ENOG4108P6C Tryptophan transporter of low affinity HVZ88_16420 ENOG4105CNH Multidrug resistance protein MdtL HVZ88_16430 ENOG4105E8Q phosphopantetheinyl transferase HVZ88_16435 ENOG4108YYH Nadph-dependent fmn reductase HVZ88_16440 ENOG4105C7N Xanthine uracil vitamin C permease HVZ88_16445 ENOG4107UB3 HAD-superfamily hydrolase subfamily IA variant 3 HVZ88_16450 ENOG4106HGK Inner membrane protein yieI HVZ88_16455 ENOG4106611 bacteriocin immunity HVZ88_16460 ENOG4107VKM 6-phosphogluconolactonase HVZ88_16465 ENOG4105DYC esterase HVZ88_16475 ENOG4105CS2 ec 3.2.1.21 HVZ88_16480 ENOG4105C5Y PTS System HVZ88_16485 ENOG4105CID antiterminator HVZ88_16490 ENOG4108UTW Plays a role in the regulation of phosphate uptake HVZ88_16495 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) HVZ88_16500 ENOG4105E2Z phosphate ABC transporter (Permease HVZ88_16505 ENOG4105C8U phosphate abc transporter HVZ88_16510 ENOG4107QMV Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity) HVZ88_16515 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) HVZ88_16565 ENOG4105GXX Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit I associates with the membrane and may be involved with cation translocation HVZ88_16580 ENOG4105QTB Flavodoxin HVZ88_16585 ENOG4108VVK transcriptional Regulator, AsnC HVZ88_16595 ENOG4105EV2 VWA domain protein interacting with AAA ATPase HVZ88_16610 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) HVZ88_16615 ENOG4105C2J ABC transporter HVZ88_16620 ENOG4105CNN ABC, transporter HVZ88_16625 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator HVZ88_16630 ENOG4108RVA ribokinase HVZ88_16635 ENOG4105ETE Transcriptional regulator (LacI family HVZ88_16640 ENOG4105C0R drug resistance transporter emrb qaca subfamily HVZ88_16645 ENOG4107EJG GntR family transcriptional regulator HVZ88_16685 ENOG4108WFC UPF0438 protein yifE HVZ88_16690 ENOG4105C0P Mg chelatase subunit ChlI HVZ88_16710 ENOG4105P3Y Acetolactate synthase 2 regulatory subunit HVZ88_16715 ENOG4105CM2 brancheD-chain amino acid aminotransferase HVZ88_16725 ENOG4105C7B Threonine dehydratase HVZ88_16730 ENOG4105EMY transcriptional regulator HVZ88_16740 ENOG4105KQ5 peptidylprolyl cis-trans isomerase HVZ88_16750 ENOG4105C4R Atp-dependent dna helicase HVZ88_16775 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) HVZ88_16780 ENOG4105ESV Glycosyl transferase, family 4 HVZ88_16785 ENOG4105SFE lipopolysaccharide biosynthesis protein HVZ88_16790 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase HVZ88_16795 ENOG4107QQG Dehydrogenase HVZ88_16800 ENOG4105C1B dTDP-glucose 4-6-dehydratase HVZ88_16805 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) HVZ88_16810 ENOG4108WJ1 acetyltransferase HVZ88_16815 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase HVZ88_16820 ENOG4105EGZ biosynthesis protein HVZ88_16825 ENOG4105F18 Catalyzes the synthesis of Und-PP-GlcNAc-ManNAcA-Fuc4NAc (Lipid III), the third lipid-linked intermediate involved in ECA synthesis (By similarity) HVZ88_16830 ENOG4105DAD Could be involved in ECA polysaccharide chain elongation (By similarity) HVZ88_16835 ENOG4108UHC Glycosyl transferase, wecb taga cpsf family HVZ88_16840 ENOG4105C85 amino acid HVZ88_16865 ENOG4105C4X radical SAM domain protein HVZ88_16870 ENOG4105ENH Sulfatase HVZ88_16875 ENOG410601J HemY protein HVZ88_16880 ENOG4105ECF c-methyltransferase HVZ88_16885 ENOG41076E6 Uroporphyrinogen-III Synthase HVZ88_16890 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) HVZ88_16895 ENOG4107T0K Adenylate cyclase HVZ88_16905 ENOG4105S7Z (LipO)protein HVZ88_16915 ENOG4105CT0 Protein of unknown function, DUF484 HVZ88_16925 ENOG4105DFC had-superfamily hydrolase, subfamily ia, variant HVZ88_16930 ENOG4105C4R Atp-dependent dna helicase HVZ88_16935 ENOG4108T58 Mg2 transport protein CorA HVZ88_16940 ENOG4107QUT magnesium and cobalt transport protein CorA HVZ88_16945 ENOG4105NRM Membrane HVZ88_16950 ENOG4106WR8 Inner membrane protein YigG HVZ88_16955 ENOG4105FR1 rard protein HVZ88_16960 ENOG4108VUY thioesterase Superfamily protein HVZ88_16965 ENOG4105HDD phospholipase HVZ88_16970 ENOG4105C9U ATP-dependent DNA helicase RecQ HVZ88_16975 ENOG4105CCF Lysine exporter protein (Lyse ygga) HVZ88_16980 ENOG410829K Lysine exporter protein (Lyse ygga) HVZ88_16985 ENOG4108EUD Lysophospholipase HVZ88_16990 ENOG4105DQF Hydrolase HVZ88_16995 ENOG4105EMK carboxylate amino acid amine transporter HVZ88_17000 ENOG4105DZ2 Transcriptional regulator HVZ88_17005 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) HVZ88_17010 ENOG4105CDZ Carboxymethylenebutenolidase (EC 3.1.1.45) HVZ88_17015 ENOG4108I5U Uridine phosphorylase HVZ88_17020 ENOG4105CGY Dna recombination protein HVZ88_17030 ENOG4105JC1 sterol-binding domain protein HVZ88_17040 ENOG4105WKS Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) HVZ88_17045 ENOG4105X8U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity) HVZ88_17050 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) HVZ88_17055 ENOG4105F8V Hydrolase, tatD family HVZ88_17060 ENOG4105MDZ Transcriptional activator rfaH HVZ88_17065 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) HVZ88_17070 ENOG4108EX3 reductase HVZ88_17075 ENOG4105CHU acetyl-coa acetyltransferase HVZ88_17090 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein HVZ88_17095 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) HVZ88_17100 ENOG4108RR8 protoporphyrinogen oxidase HVZ88_17130 ENOG4105FNP Molybdopterin-guanine dinucleotide biosynthesis protein b HVZ88_17135 ENOG4105C6R Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) HVZ88_17140 ENOG4105PC1 Conserved Protein HVZ88_17145 ENOG4105E27 serine threonine protein kinase HVZ88_17150 ENOG4108Z33 Thiol disulfide Interchange Protein HVZ88_17160 ENOG4106HNH Acyl-transferase HVZ88_17165 ENOG4105C2M dna polymerase I HVZ88_17175 ENOG4105ZR3 A GTPase-activating protein (GAP) that modifies Der EngA GTPase function. May play a role in ribosome biogenesis (By similarity) HVZ88_17180 ENOG4105D4P Coproporphyrinogen iii oxidase HVZ88_17185 ENOG4106FIY HVZ88_17190 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family HVZ88_17195 ENOG4105CUX Signal transduction histidine kinase HVZ88_17200 ENOG4105C5F glutamine synthetase HVZ88_17205 ENOG4105CI3 gtp-binding protein typa HVZ88_17210 ENOG4108K85 Transcriptional regulator HVZ88_17215 ENOG4108KHF Resistance protein HVZ88_17220 ENOG4105R9B Major Facilitator HVZ88_17225 ENOG4108KUC Outer membrane channel protein that allows an efficient diffusion of low-molecular-weight solutes such as small sugars and tetraglycine. However, the specific substrate recognized by the OmpL channel is HVZ88_17230 ENOG4105CT4 transporter HVZ88_17235 ENOG4105CT4 transporter HVZ88_17240 ENOG4105CJQ hydrolase, family 31 HVZ88_17250 ENOG4107WI4 Aldose-1-epimerase HVZ88_17255 ENOG4107QKS N-acylglucosamine 2-epimerase HVZ88_17260 ENOG4105D2M Aldolase HVZ88_17265 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase HVZ88_17270 ENOG4108MGF sugar kinase HVZ88_17275 ENOG4105E98 transcriptional regulator DeoR family HVZ88_17280 ENOG4105EJU HAD-superfamily hydrolase subfamily IA variant 3 HVZ88_17295 ENOG4105SUU thioesterase domain HVZ88_17305 ENOG41068KX affects formate dehydrogenase-N HVZ88_17315 ENOG4108MG3 formate dehydrogenase HVZ88_17320 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein HVZ88_17330 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) HVZ88_17335 ENOG4108V87 frv operon regulatory protein HVZ88_17340 ENOG4106C3V frv operon regulatory protein HVZ88_17345 ENOG4105CN9 Peptidase m42 family protein HVZ88_17350 ENOG4105DM4 PTS System HVZ88_17355 ENOG41064BA PTS system, fructose-specific, IIA component HVZ88_17370 ENOG4105DKG l-rhamnose isomerase HVZ88_17395 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) HVZ88_17405 ENOG4108RPX mosc domain containing protein HVZ88_17410 ENOG4105E0F Histidine kinase HVZ88_17415 ENOG4105E3W Two component transcriptional regulator (Winged helix family HVZ88_17420 ENOG4105FMW periplasmic HVZ88_17435 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein HVZ88_17450 ENOG4105EBK exported protein HVZ88_17455 ENOG4108VTS Membrane HVZ88_17460 ENOG41065TG regulatoR HVZ88_17470 ENOG4105DP0 ferredoxin-NADP reductase HVZ88_17475 ENOG4105CBT Fructose-1,6-bisphosphatase HVZ88_17485 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) HVZ88_17500 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase HVZ88_17515 ENOG41063M6 Cell Division Protein HVZ88_17520 ENOG4105ETE Transcriptional regulator (LacI family HVZ88_17525 ENOG4105C25 Primosomal protein n' HVZ88_17535 ENOG4107S01 Repressor protein MetJ HVZ88_17545 ENOG4105C28 cystathionine HVZ88_17550 ENOG4105CFH Aspartokinase HVZ88_17555 ENOG4105SYT Methylenetetrahydrofolate reductase HVZ88_17565 ENOG4108Q5Y Membrane HVZ88_17570 ENOG4108XC3 NADH ubiquinone oxidoreductase HVZ88_17575 ENOG4105DCT glycerol dehydrogenase HVZ88_17580 ENOG4107T9Z Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) HVZ88_17585 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) HVZ88_17590 ENOG4105DM4 PTS System HVZ88_17595 ENOG4108YRF PTS System HVZ88_17605 ENOG4108AHH pyruvate formate lyase II activase HVZ88_17610 ENOG4108XCZ PTS System HVZ88_17615 ENOG4106R3P AraC family transcriptional regulator HVZ88_17620 ENOG4105DIJ Phosphoethanolamine transferase HVZ88_17625 ENOG4105CCA Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle (By similarity) HVZ88_17630 ENOG4105CWC Acetylornithine deacetylase HVZ88_17635 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase HVZ88_17650 ENOG4105C5Q Transcriptional regulator HVZ88_17660 ENOG4105EJ2 Transcriptional regulator HVZ88_17665 ENOG4108Y73 Membrane HVZ88_17675 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) HVZ88_17680 ENOG4105F03 Provides the (R)-glutamate required for cell wall biosynthesis (By similarity) HVZ88_17705 ENOG4105D4A Cell wall formation (By similarity) HVZ88_17710 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase HVZ88_17745 ENOG4105PM1 preprotein translocase subunit SecE HVZ88_17750 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) HVZ88_17785 ENOG410645W Thiamin biosynthesis protein ThiH HVZ88_17790 ENOG4105D41 biosynthesis protein thiH HVZ88_17795 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) HVZ88_17800 ENOG4105WHD thiamine biosynthesis protein ThiS HVZ88_17805 ENOG4105D06 uba thif-type nad fad binding protein HVZ88_17815 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) HVZ88_17840 ENOG4105R2J Conserved Protein HVZ88_17850 ENOG4108T8B Protein of unknown function (DUF1481) HVZ88_17855 ENOG4105JBU Binds zinc. Could be an important component of the zinc- balancing mechanism HVZ88_17860 ENOG4105BZU Histidine kinase HVZ88_17865 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family HVZ88_17870 ENOG4105C12 Phosphoribosylglycinamide synthetase HVZ88_17875 ENOG4105DC1 bifunctional purine biosynthesis protein purh HVZ88_17900 ENOG41062WK cellular response to acidity HVZ88_17905 ENOG4105K5X acetyltransferase HVZ88_17910 ENOG4105CVG Homoserine O-transsuccinylase HVZ88_17915 ENOG4107QP3 malate synthase g HVZ88_17920 ENOG4108I9X Isocitrate lyase HVZ88_17925 ENOG4105VS7 Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation (By similarity) HVZ88_17935 ENOG41069M3 Transcriptional regulator HVZ88_17940 ENOG4105C3R Methionine synthase HVZ88_17945 ENOG4105EAM Na Pi-cotransporter HVZ88_17955 ENOG4105FE9 pseudouridine synthase HVZ88_17960 ENOG4108ZR5 Conserved Protein HVZ88_17965 ENOG4105CFH Aspartokinase HVZ88_17970 ENOG4107QP8 phosphohexose isomerase HVZ88_17980 ENOG4108MDC (LipO)protein HVZ88_17985 ENOG4108Q9C Periplasmic Protein HVZ88_17990 ENOG4105E3R (LipO)protein HVZ88_18005 ENOG4107QNK )-transporter HVZ88_18010 ENOG4105EG2 ABC transporter, permease HVZ88_18015 ENOG4105D56 permease protein HVZ88_18020 ENOG4107FKK extracellular solute-binding protein family 1 HVZ88_18025 ENOG4108IJ9 (ABC) transporter HVZ88_18035 ENOG4107W52 maltose operon periplasmic protein HVZ88_18045 ENOG4105VEI Removes the pyruvyl group from chorismate, with concomitant aromatization of the ring, to provide 4- hydroxybenzoate (4HB) for the ubiquinone pathway (By similarity) HVZ88_18060 ENOG41080IJ Diacylglycerol kinase HVZ88_18070 ENOG4107R73 Mate efflux family protein HVZ88_18075 ENOG4105VDW Csbd family HVZ88_18080 ENOG4105MYN Zinc uptake regulation protein HVZ88_18090 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) HVZ88_18095 ENOG4105P4Z Phage shock protein G HVZ88_18100 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein HVZ88_18105 ENOG4105CDU Replicative dna helicase HVZ88_18110 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) HVZ88_18115 ENOG4105CGF Aromatic amino acid aminotransferase HVZ88_18125 ENOG4105F0S class B acid phosphatase HVZ88_18130 ENOG4108YXI Secondary thiamine-phosphate synthase enzyme HVZ88_18135 ENOG4105MSB protein, conserved in bacteria HVZ88_18140 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) HVZ88_18145 ENOG4108UUM single-stranded DNA-binding protein HVZ88_18150 ENOG4105PMV Membrane HVZ88_18155 ENOG4108M8H domain protein HVZ88_18160 ENOG4108W3Q Transcriptional regulator HVZ88_18165 ENOG4108Z4X TRANSCRIPTIONal HVZ88_18170 ENOG4105C7N Xanthine uracil vitamin C permease HVZ88_18175 ENOG4105EEQ Na H antiporter HVZ88_18190 ENOG41062QD Membrane HVZ88_18195 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) HVZ88_18205 ENOG4105JJ8 Cytochrome c nitrite reductase, pentaheme subunit HVZ88_18210 ENOG4105D3S 4Fe-4S Ferredoxin, iron-sulfur binding domain protein HVZ88_18215 ENOG4105DVI reductase, NrfD HVZ88_18220 ENOG4108QKW cytochrome c-type biogenesis protein HVZ88_18230 ENOG4108W0S formate-dependent nitrite reductase complex HVZ88_18235 ENOG4105CK2 sodium dicarboxylate symporter HVZ88_18240 ENOG41082ND Uncharacterized protein yjcO HVZ88_18255 ENOG4108MI0 Resistance protein HVZ88_18260 ENOG4105J12 Multidrug resistance protein mdtN HVZ88_18265 ENOG4106833 HVZ88_18270 ENOG4105EUZ Beta-lactamase domain protein HVZ88_18275 ENOG4107TFG D-allose kinase HVZ88_18280 ENOG4105UP7 3-epimerase HVZ88_18285 ENOG4105CNN ABC, transporter HVZ88_18290 ENOG4105C2J ABC transporter HVZ88_18295 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator HVZ88_18300 ENOG4105NYY transcriptional regulator, RpiR HVZ88_18305 ENOG4108YZG isomerase HVZ88_18315 ENOG4107SA6 carbon-phosphorus lyase complex accessory protein HVZ88_18320 ENOG410849A acetyltransferase, (GNAT) family HVZ88_18325 ENOG4105MFQ Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP) (By similarity) HVZ88_18330 ENOG4105FD8 phosphonate metabolism protein PhnM HVZ88_18335 ENOG4105HRV phosphonate c-p lyase system protein phnl HVZ88_18340 ENOG4105ENV phosphonate C-P lyase system protein PhnK HVZ88_18345 ENOG4105FT8 Phosphonate metabolism HVZ88_18350 ENOG4105EKV Phosphonate metabolism protein HVZ88_18355 ENOG4105KZ6 phosphonate C-P lyase system protein PhnH HVZ88_18360 ENOG4105KQZ Phosphonate C-P lyase system protein PhnG HVZ88_18365 ENOG4107RJJ Transcriptional regulator HVZ88_18380 ENOG4105D5T phosphonate abc transporter HVZ88_18385 ENOG4108SQ4 Glyoxalase Bleomycin resistance protein (Dioxygenase HVZ88_18390 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA HVZ88_18395 ENOG4108F5E vimentin HVZ88_18400 ENOG4108YIV HVZ88_18405 ENOG4105CSH Transporter HVZ88_18415 ENOG4105ECM Sensor protein basS pmrB HVZ88_18420 ENOG4105XJC Two component transcriptional regulator (Winged helix family HVZ88_18425 ENOG4105DIJ Phosphoethanolamine transferase HVZ88_18430 ENOG4105D5Q Arginine ornithine antiporter HVZ88_18435 ENOG4106ZGR Transcriptional regulator HVZ88_18440 ENOG4105CXN decarboxylase HVZ88_18445 ENOG4108K2B transcriptional regulator HVZ88_18450 ENOG4105F8D glycoside hydrolase family 4 HVZ88_18470 ENOG4108R5S membrane HVZ88_18475 ENOG4107GFK fumarate HVZ88_18480 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter HVZ88_18485 ENOG4108MRH transcriptional regulatory protein HVZ88_18490 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism HVZ88_18495 ENOG4105VR1 Pfam:DUF1271 HVZ88_18500 ENOG410830R acetyltransferase HVZ88_18515 ENOG4105CRK lysyL-tRNA synthetase HVZ88_18520 ENOG4105DUX Transporter HVZ88_18525 ENOG4105CXN decarboxylase HVZ88_18530 ENOG4105D5Q Arginine ornithine antiporter HVZ88_18535 ENOG4108M3R transcriptional activator CadC HVZ88_18540 ENOG4105BZU Histidine kinase HVZ88_18575 ENOG4105MAW Antitoxin component of a toxin-antitoxin (TA) module. Labile antitoxin that counteracts the effect of the CbtA (YeeV) toxin. It does not bind to the cognate toxin but instead binds to MreB and FtsZ (the toxin targets), enhancing their polymerization by forming higher-order bundles HVZ88_18585 ENOG4108YGG dna repair protein HVZ88_18590 ENOG4106549 Antirestriction protein HVZ88_18595 ENOG4106H6R UPF0380 protein HVZ88_18600 ENOG4105F4K antigen 43 HVZ88_18610 ENOG4108P8R HVZ88_18655 ENOG4105HMV Fimbrial protein HVZ88_18660 ENOG4108SER Transposase HVZ88_18665 ENOG4108ZJG MrfB protein HVZ88_18670 ENOG4106PG1 outer membrane usher protein HVZ88_18675 ENOG4106P2F Pfam:Pili_assembly_C HVZ88_18685 ENOG4106CXJ Residues 2 to 179 of 179 are 100.00 pct identical to residues 1 to 178 of 178 from SwissProt.40 sp P42190 PAPK_ECOLI PROTEIN PAPK PRECURSOR HVZ88_18710 ENOG4108Z33 Thiol disulfide Interchange Protein HVZ88_18725 ENOG4105D5K Hemolysin activator protein HVZ88_18735 ENOG4105CKT filamentous hemagglutinin HVZ88_18760 ENOG4105CKT filamentous hemagglutinin HVZ88_18765 ENOG4105CKT filamentous hemagglutinin HVZ88_18770 ENOG4105UPP uncharacterized protein ydcA HVZ88_18795 ENOG4105BZV Phosphoadenosine phosphosulfate reductase HVZ88_18800 ENOG4105GTN ParB Domain Protein Nuclease HVZ88_18820 ENOG4107QRT dEAD DEAH box helicase HVZ88_18840 ENOG4105T40 surface antigen msp4 family protein HVZ88_18845 ENOG4108I6E Sulfatase HVZ88_18860 ENOG4108SIC Transcriptional regulator HVZ88_18865 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) HVZ88_18875 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter HVZ88_18880 ENOG4108IJ0 Aspartate ammonia-lyase HVZ88_18885 ENOG4108YH1 overproduction of this protein in Escherichia coli inhibits the F plasmid-mediated exclusion of bacteriophage T7 HVZ88_18890 ENOG4105DVH amino acid HVZ88_18905 ENOG4108ZVF (LipO)protein HVZ88_18910 ENOG4105MTB Uncharacterized protein YjeJ HVZ88_18915 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein HVZ88_18925 ENOG4107PEH Entericidin EcnA/B family HVZ88_18930 ENOG4106BSU Entericidin B HVZ88_18935 ENOG4105KPY Small multidrug resistance protein HVZ88_18940 ENOG4105QNF Outer membrane lipoprotein HVZ88_18945 ENOG41066YJ Beta-lactamase HVZ88_18960 ENOG4105E33 succinate dehydrogenase HVZ88_18965 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) HVZ88_18975 ENOG4107SC7 Inner membrane transporter yjeM HVZ88_18980 ENOG4106V5W HVZ88_18985 ENOG4106CG8 Inner membrane protein YjeO HVZ88_18990 ENOG4105EGS Mechanosensitive ion channel HVZ88_19030 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) HVZ88_19035 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) HVZ88_19040 ENOG4105K8N protein family UPF0079, ATPase HVZ88_19045 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase HVZ88_19050 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) HVZ88_19065 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) HVZ88_19070 ENOG4107QJR hflk protein HVZ88_19075 ENOG4105EPW hflc protein HVZ88_19095 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) HVZ88_19100 ENOG4105C2N RNA methyltransferase TrmH family group 3 HVZ88_19105 ENOG4105FUX Conserved Protein HVZ88_19110 ENOG4108P9J Phage shock protein A HVZ88_19115 ENOG4107VNS Protein of unknown function (DUF2491) HVZ88_19120 ENOG4105Z6B inner membrane protein yjfl HVZ88_19125 ENOG4108KXT Conserved Protein HVZ88_19130 ENOG4106032 Glutathionylspermidine synthase HVZ88_19135 ENOG4105CSU acyl-Coa dehydrogenase HVZ88_19140 ENOG4105S17 UPF0379 protein yjfN HVZ88_19145 ENOG4105WSB biofilm stress and motility protein A HVZ88_19150 ENOG4108MXZ Esterase HVZ88_19165 ENOG4105CZC PTS system ascorbate-specific transporter subunit IIC HVZ88_19170 ENOG410907W The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in ascorbate transport HVZ88_19190 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase HVZ88_19195 ENOG4105KIT UPF0379 protein yjfY HVZ88_19210 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) HVZ88_19220 ENOG4105DPW Major facilitator superfamily MFS_1 HVZ88_19225 ENOG4107S3R L-aspartate oxidase HVZ88_19230 ENOG4107R0K CoA transferase having broad substrate specificity for short-chain acyl-CoA thioesters with the activity decreasing when the length of the carboxylic acid chain exceeds four carbons (By similarity) HVZ88_19235 ENOG4105E39 Enoyl-CoA hydratase HVZ88_19245 ENOG4105CHR reductase HVZ88_19255 ENOG4105FHY Opacity-associated protein A HVZ88_19260 ENOG4108V1T peptidylprolyl cis-trans isomerase HVZ88_19265 ENOG4105C85 amino acid HVZ88_19275 ENOG4105DXC membrane HVZ88_19280 ENOG4105ECR NmrA family HVZ88_19285 ENOG4105KVH Transcriptional regulator HVZ88_19290 ENOG4107RNS bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase 3'-nucleotidase periplasmic HVZ88_19295 ENOG4108RNI 3'(2')5'-bisphosphate nucleotidase HVZ88_19300 ENOG4108UUE Transcriptional regulator HVZ88_19305 ENOG41061GZ Protein of unknown function (DUF1107) HVZ88_19310 ENOG4105C37 (CBS) domain HVZ88_19320 ENOG4105CFU surface antigen HVZ88_19325 ENOG4105MA0 exported protein HVZ88_19330 ENOG4108ZHD aig2 family HVZ88_19335 ENOG4105F0N pyrophosphate phospho-hydrolase HVZ88_19340 ENOG4107R5U Periplasmic binding protein LacI transcriptional regulator HVZ88_19345 ENOG4105C2J ABC transporter HVZ88_19350 ENOG4107R9N ABC transporter HVZ88_19355 ENOG41062B0 ABC transporter, permease HVZ88_19365 ENOG4105DFU Cell wall formation (By similarity) HVZ88_19375 ENOG4105CMS peptidase U62, modulator of DNA gyrase HVZ88_19385 ENOG4108RDD Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine (By similarity) HVZ88_19390 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase HVZ88_19395 ENOG4105CG3 alpha amylase, catalytic region HVZ88_19400 ENOG4105C5Y PTS System HVZ88_19405 ENOG4105D4X repressor HVZ88_19415 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic HVZ88_19420 ENOG4105KME endoribonuclease L-psp HVZ88_19435 ENOG4107C93 pyrBI operon leader peptide HVZ88_19440 ENOG4108UQ8 endoribonuclease L-psp HVZ88_19445 ENOG4105F6U Short-chain dehydrogenase reductase Sdr HVZ88_19450 ENOG4108XFH Transcriptional regulator HVZ88_19455 ENOG4105XEP YhcH YjgK YiaL family protein HVZ88_19470 ENOG4105KQT Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome (By similarity) HVZ88_19475 ENOG4108MJ3 acetyltransferase HVZ88_19480 ENOG4108M3P Membrane HVZ88_19490 ENOG4105MYG DNA polymerase iii, chi subunit HVZ88_19500 ENOG4108M8S permease YjgP YjgQ family protein HVZ88_19505 ENOG4108K5H permease YjgP YjgQ family protein HVZ88_19510 ENOG4105D7A ATP-binding protein HVZ88_19515 ENOG4105DQ4 alcohol dehydrogenase HVZ88_19605 ENOG4108MX5 Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses (By similarity) HVZ88_19610 ENOG41069FU Outer membrane channel protein allowing the entry of N- acetylneuraminic acid (Neu5Ac, the most abundant sialic acid on host cell surfaces) into the bacteria HVZ88_19620 ENOG4108W9T type 1 fimbriae regulatory protein HVZ88_19625 ENOG4105E71 FimE is one of the 2 regulatory proteins which control the phase variation of type 1 fimbriae in E.coli. These proteins mediate the periodic inversion of a 300bp DNA segment that harbors the promoter for the fimbrial structural gene, fimA. FimE switches fimA off HVZ88_19635 ENOG4108S54 Fimbrial protein HVZ88_19640 ENOG4108NAE Fimbrial chaperone protein HVZ88_19645 ENOG4105CW0 outer membrane usher protein HVZ88_19650 ENOG4108SQA Fimbrial HVZ88_19655 ENOG4108T65 Fimbrial HVZ88_19660 ENOG410643X FIMH SUBUNIT MANNOSE-sensitive type 1 fimbrial adhesin HVZ88_19675 ENOG4105DEI Mannitol dehydrogenase HVZ88_19680 ENOG4105C6F GntR Family Transcriptional Regulator HVZ88_19700 ENOG4107YNJ LysR family Transcriptional regulator HVZ88_19705 ENOG4105DYB Isoaspartyl dipeptidase HVZ88_19710 ENOG4108P2H Inner membrane protein YjiG HVZ88_19715 ENOG41074DU domain protein HVZ88_19725 ENOG4105CBP Major Facilitator HVZ88_19740 ENOG4105CIZ coA-substrate-specific enzyme activase HVZ88_19745 ENOG4105DCU 2-hydroxyglutaryl-CoA dehydratase HVZ88_19750 ENOG4106BRA Membrane HVZ88_19755 ENOG41083G8 Multidrug resistance protein MdtM HVZ88_19765 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HVZ88_19770 ENOG4106DIZ Domain of unknown function (DUF1127) HVZ88_19785 ENOG4107QTH restriction modification system DNA specificity domain HVZ88_19810 ENOG4105CKI cobalamin synthesis protein HVZ88_19815 ENOG4105VCD cytoplasmic protein HVZ88_19820 ENOG4105D22 carbon starvation protein HVZ88_19825 ENOG4107UWN reductase HVZ88_19830 ENOG4105EFA 4-hydroxyphenylacetate HVZ88_19860 ENOG4107THI 3,4-dihydroxyphenylacetate 2,3-dioxygenase HVZ88_19865 ENOG4105C26 Dehydrogenase HVZ88_19870 ENOG4105ERH Fumarylacetoacetate hydrolase HVZ88_19875 ENOG4108V8F Transcriptional regulator, MarR family HVZ88_19880 ENOG4105C8Q Methyl-accepting chemotaxis HVZ88_19885 ENOG4105CG6 trap dicarboxylate transporter dctm subunit HVZ88_19895 ENOG4108ERU trap dicarboxylate transporter subunit DctP HVZ88_19900 ENOG4105EEQ Na H antiporter HVZ88_19905 ENOG410617M Transcriptional regulator HVZ88_19910 ENOG4105CPQ Dehydrogenase HVZ88_19920 ENOG4105RI1 glycoprotein receptor HVZ88_19925 ENOG4106CVF DNA replication protein HVZ88_19940 ENOG4105DWK Membrane HVZ88_19945 ENOG4108N8T regulatoR HVZ88_19950 ENOG4108T94 DNA-binding transcriptional activator BglJ HVZ88_19955 ENOG4108819 ferric iron reductase HVZ88_19960 ENOG4105YBH Protein of unknown function (DUF1435) HVZ88_19980 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) HVZ88_19985 ENOG4108WPU DNA polymerase III subunit psi HVZ88_19990 ENOG4105KEG ribosomal-protein-alanine acetyltransferase HVZ88_19995 ENOG4105PAD Hydrolase HVZ88_20005 ENOG4105K3G Periplasmic Protein HVZ88_20015 ENOG4108NRW Phospholipase, patatin family HVZ88_20020 ENOG4105EYA deoxyribonuclease HVZ88_20025 ENOG41076CZ activating enzyme HVZ88_20030 ENOG4105G0K glycine radical enzyme YjjI family HVZ88_20050 ENOG4105D3A purine nucleoside phosphorylase DeoD-type HVZ88_20065 ENOG41062Z9 Membrane HVZ88_20070 ENOG4105EAC phosphoserine phosphatase HVZ88_20075 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) HVZ88_20080 ENOG4107VZS Nicotinamide-nucleotide adenylyltransferase HVZ88_20085 ENOG4105C5H ABC transporter HVZ88_20090 ENOG4107SC1 transglycosylase HVZ88_20100 ENOG4108K16 Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) HVZ88_20110 ENOG4105UEI Transcriptional Regulator AraC Family HVZ88_20115 ENOG4108RH0 Crea protein HVZ88_20120 ENOG4105E3W Two component transcriptional regulator (Winged helix family HVZ88_20125 ENOG4105EB3 Histidine kinase HVZ88_20130 ENOG4105CT7 inner membrane cred family protein HVZ88_20135 ENOG41065U4 response regulator HVZ88_20140 ENOG410759A HVZ88_20145 ENOG4106FVC RNA methyltransferase HVZ88_20155 ENOG4105CFH Aspartokinase HVZ88_20165 ENOG4105D98 threonine synthase HVZ88_20170 ENOG41062C6 Protein of unknown function (DUF2502) HVZ88_20180 ENOG4105BZG amino acid carrier protein HVZ88_20190 ENOG4108RIR Molybdenum cofactor biosynthesis protein HVZ88_20195 ENOG4106HK8 GPR1 FUN34 yaaH family protein HVZ88_20200 ENOG4108QUJ UPF0174 protein YaaW HVZ88_20220 ENOG4108SER Transposase HVZ88_20225 ENOG4105WI6 cell killing protein encoded within cryptic prophage HVZ88_20235 ENOG41063Z6 transcriptional regulator, lysR family HVZ88_20260 ENOG410647N response to DNA damage stimulus HVZ88_20265 ENOG4105DTN riboflavin biosynthesis protein ribF HVZ88_20280 ENOG41090X3 Peptidyl-prolyl cis-trans isomerase HVZ88_20300 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain HVZ88_20305 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain HVZ88_20310 ENOG4108XNW Transcriptional activatory protein CaiF HVZ88_20315 ENOG4108Z0R Transferase HVZ88_20320 ENOG4106YT9 Enoyl-CoA hydratase HVZ88_20325 ENOG4105CEY Amp-dependent synthetase and ligase HVZ88_20330 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F HVZ88_20355 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase HVZ88_20360 ENOG4105IBM Could be part of an electron transfer system required for anaerobic carnitine reduction. Could be a 3Fe-4S cluster- containing protein HVZ88_20365 ENOG4105C54 Major Facilitator superfamily HVZ88_20375 ENOG4105CKD glutathione-regulated potassium-efflux system protein HVZ88_20380 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) HVZ88_20385 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) HVZ88_20400 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) HVZ88_20405 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) HVZ88_20410 ENOG4105E7H involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity) HVZ88_20415 ENOG41066UG Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host (By similarity) HVZ88_20435 ENOG4105D3G Pseudouridine synthase HVZ88_20440 ENOG4105BZK Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair (By similarity) HVZ88_20445 ENOG4105CQ2 DNA polymerase HVZ88_20450 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase HVZ88_20455 ENOG4105CAC Catalyzes the conversion of L-arabinose to L-ribulose (By similarity) HVZ88_20460 ENOG4105EF1 ribulokinase HVZ88_20465 ENOG41063TF transcriptional regulator (AraC HVZ88_20470 ENOG4108KF1 Membrane HVZ88_20475 ENOG4107T0D ABC, transporter HVZ88_20480 ENOG4106SMU thiamine transporter membrane protein HVZ88_20485 ENOG4105DP9 ABC transporter HVZ88_20490 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) HVZ88_20500 ENOG4105S8Q sugar efflux transporter HVZ88_20515 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) HVZ88_20530 ENOG41064T2 transcriptional regulator, lysR family HVZ88_20540 ENOG4105C7K acetolactate synthase HVZ88_20545 ENOG4108ZP8 Acetolactate synthase small subunit HVZ88_20555 ENOG4107B7Y DNA-binding transcriptional regulator FruR HVZ88_20560 ENOG4108V6E Cell division protein mraZ HVZ88_20570 ENOG41063Y6 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) HVZ88_20575 ENOG4105CJN penicillin-binding protein HVZ88_20580 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) HVZ88_20585 ENOG4108EQQ Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity) HVZ88_20595 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) HVZ88_20600 ENOG4105CNI cell division protein FtsW HVZ88_20605 ENOG4105DVQ Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc- (pentapeptide)GlcNAc (lipid intermediate II) (By similarity) HVZ88_20610 ENOG4105DFU Cell wall formation (By similarity) HVZ88_20615 ENOG4105CPF Cell wall formation (By similarity) HVZ88_20620 ENOG4105K7E Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity) HVZ88_20625 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) HVZ88_20630 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) HVZ88_20640 ENOG4108SR7 Regulates secA expression by translational coupling of the secM secA operon. Translational pausing at a specific Pro residue 5 residues before the end of the protein may allow disruption of a mRNA repressor helix that normally suppresses secA translation initiation (By similarity) HVZ88_20650 ENOG4105M6F mutator MutT protein HVZ88_20665 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) HVZ88_20680 ENOG4105D7Q type ii secretion system HVZ88_20685 ENOG4107QHF type ii secretion system protein e HVZ88_20690 ENOG4108ZUW Major pilin subunit HVZ88_20695 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase HVZ88_20700 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase HVZ88_20705 ENOG4106A72 regulatory protein AmpE HVZ88_20710 ENOG4105C85 amino acid HVZ88_20715 ENOG41073TP transcriptional regulator HVZ88_20720 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) HVZ88_20725 ENOG4107QSN dihydrolipoamide acetyltransferase HVZ88_20730 ENOG4107QN2 dihydrolipoyl dehydrogenase HVZ88_20735 ENOG4108NST exported protein HVZ88_20740 ENOG4107QIJ Aconitate hydratase 2 HVZ88_20760 ENOG4108ZRK uncharacterized protein yacC HVZ88_20765 ENOG4105E3B Multicopper oxidase HVZ88_20770 ENOG4105DZG Dehydrogenase HVZ88_20775 ENOG4108UGV hypoxanthine phosphoribosyltransferase HVZ88_20780 ENOG41077A9 carbonic anhydrase HVZ88_20785 ENOG4105DA5 (ABC) transporter HVZ88_20790 ENOG4105E3A (ABC) transporter HVZ88_20795 ENOG4108YTN IIa component HVZ88_20800 ENOG4107BJW polysaccharide deacetylase HVZ88_20810 ENOG4108A32 Transposase HVZ88_20820 ENOG4105CCG Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is tranferred onto alpha-ketoisovalerate to form ketopantoate (By similarity) HVZ88_20825 ENOG4105P0Q fimbrial-like protein YadC HVZ88_20830 ENOG4105SN2 fimbrial-like adhesin protein HVZ88_20835 ENOG4105SYG Fimbrial protein HVZ88_20840 ENOG4108XEY fimbrial-like adhesin protein HVZ88_20845 ENOG4105CW0 outer membrane usher protein HVZ88_20850 ENOG4108VEV chaperone HVZ88_20860 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase HVZ88_20865 ENOG4105DJ0 Poly(A) Polymerase HVZ88_20885 ENOG4107XID 2'-5' rna ligase HVZ88_20890 ENOG4105CQ7 ATP-dependent helicase HVZ88_20895 ENOG4105BZ4 penicillin-binding protein HVZ88_20900 ENOG4105E0K tonB-dependent siderophore receptor HVZ88_20905 ENOG4105E0A ABC, transporter HVZ88_20910 ENOG4105J76 Periplasmic binding protein HVZ88_20915 ENOG4105S6R Iron-hydroxamate transporter permease subunit HVZ88_20940 ENOG4105EN6 Membrane HVZ88_20945 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) HVZ88_20960 ENOG4105C0H protease HVZ88_20965 ENOG4108IXP Carbohydrate diacid transcriptional activator CdaR HVZ88_20975 ENOG4105DIN metallophosphoesterase HVZ88_20985 ENOG4105E1P Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity) HVZ88_20990 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) HVZ88_21015 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) HVZ88_21020 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) HVZ88_21025 ENOG4105KNE Phosphatidate cytidylyltransferase HVZ88_21030 ENOG4105DZP Membrane-associated zinc metalloprotease HVZ88_21040 ENOG4108RFI Molecular chaperone that interacts specifically with outer membrane proteins, thus maintaining the solubility of early folding intermediates during passage through the periplasm (By similarity) HVZ88_21045 ENOG4105D7M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) HVZ88_21070 ENOG4105C0B DNA polymerase III (alpha subunit) HVZ88_21080 ENOG4105CXN decarboxylase HVZ88_21085 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase HVZ88_21090 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) HVZ88_21095 ENOG4105M1T rho-binding antiterminator HVZ88_21105 ENOG4108VWS Yaeq family HVZ88_21110 ENOG4108YZN class I peptide chain release factor HVZ88_21115 ENOG4107EII Lipoprotein involved with copper homeostasis and adhesion HVZ88_21120 ENOG4108UY0 (LipO)protein HVZ88_21130 ENOG4108R96 Methyltransferase, YaeB family HVZ88_21135 ENOG4108R8X outer membrane lipoprotein HVZ88_21140 ENOG4105D01 (LipO)protein HVZ88_21145 ENOG4108UMI ABC transporter, permease HVZ88_21150 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) HVZ88_21155 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase HVZ88_21190 ENOG4105CV8 reductase HVZ88_21195 ENOG4105HEI LysR family (Transcriptional regulator HVZ88_21210 ENOG4105E9H Lytic Murein transglycosylase HVZ88_21215 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) HVZ88_21220 ENOG4105D1A Methyltransferase HVZ88_21230 ENOG4107RZZ dna polymerase iii epsilon subunit HVZ88_21240 ENOG410600K aminopeptidase HVZ88_21255 ENOG4105GMB type VI secretion system effector, hcp1 family HVZ88_21280 ENOG410600T transposase HVZ88_21285 ENOG4105CZ7 nitrilase cyanide hydratase and apolipoprotein n-acyltransferase HVZ88_21290 ENOG4108WN0 inhibitor of vertebrate lysozyme HVZ88_21295 ENOG4107QPN acyl-Coa dehydrogenase HVZ88_21305 ENOG4105E7A Glutamine amidotransferase HVZ88_21310 ENOG4105F7V ErfK ybiS ycfS ynhG family protein HVZ88_21315 ENOG4105VXN addiction module toxin, RelE StbE family HVZ88_21320 ENOG4105QHH Antitoxin component of a toxin-antitoxin (TA) module. A labile antitoxin that counteracts the effect of the YafQ toxin. YafQ and DinJ together bind their own promoter, and by analogy to other TA modules probably repress its expression HVZ88_21325 ENOG4108YS0 lipoprotein YafL HVZ88_21330 ENOG4108UK5 Transposase HVZ88_21340 ENOG4105D00 flagellar biosynthetic protein flhB HVZ88_21345 ENOG4105D19 Role in flagellar biosynthesis (By similarity) HVZ88_21350 ENOG4105VS8 Flagellar biosynthetic protein fliq HVZ88_21355 ENOG4105CN7 Flagellar biosynthetic protein FliP HVZ88_21360 ENOG4105DD5 Flagellar motor switch protein HVZ88_21380 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) HVZ88_21385 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) HVZ88_21395 ENOG4108JIR Flagellum-specific ATP synthase HVZ88_21405 ENOG4107ZIC Glycerol-3-phosphate cytidylyltransferase HVZ88_21435 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) HVZ88_21440 ENOG4108ZC9 flagellar basal-body rod protein flgc HVZ88_21450 ENOG4105BZE flagellar hook protein, FlgE HVZ88_21455 ENOG4108KPB Flagellar basal-body rod protein FlgF HVZ88_21460 ENOG4105CGA flagellar basal-body rod protein FlgG HVZ88_21475 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj HVZ88_21485 ENOG4105DTJ flagellar hook-associated protein HVZ88_21500 ENOG4105I03 Flagellin HVZ88_21505 ENOG410804A Flagellar hook-associated 2 domain-containing protein HVZ88_21535 ENOG4107RD7 Flagellar Motor Protein, MotA HVZ88_21545 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) HVZ88_21550 ENOG4105UG9 Antitoxin of the YafO-YafN toxin-antitoxin system HVZ88_21555 ENOG41065DM this blockage is overcome by subsequent expression of antitoxin YafN. Overexpression causes cleavage of a number of mRNAs in a ribosome-dependent fashion. YafO binding to the 50S ribosomal subunit in the translation complex induces mRNA cleavage 3' to the region protected by the ribosome HVZ88_21560 ENOG4108HYG acetyltransferase HVZ88_21570 ENOG4108S2Y peptide Chain Release factor HVZ88_21575 ENOG4105CIN aminoacyl-histidine dipeptidase HVZ88_21585 ENOG4105V1F Fermentation respiration switch protein HVZ88_21595 ENOG4105FCK Membrane HVZ88_21605 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) HVZ88_21615 ENOG4108KU3 Integrase HVZ88_21670 ENOG4108V2F protein ybcN in lambdoid DLP12 prophage regi HVZ88_21675 ENOG410757E Protein NinE homolog from lambdoid prophage DLP12 HVZ88_21680 ENOG4105RWQ Protein of unknown function (DUF1364) HVZ88_21695 ENOG4105HRS Antitermination protein HVZ88_21705 ENOG4105QFS Lysis protein S homolog from lambdoid prophage HVZ88_21710 ENOG4105KUS lysozyme HVZ88_21720 ENOG4105QYK bacteriophage lambda Bor protein homolog HVZ88_21750 ENOG4105Y9F tail fiber protein HVZ88_21755 ENOG4108US3 tail fiber assembly HVZ88_21760 ENOG4105PTU response to oxidative stress HVZ88_21770 ENOG4108C33 Resolvase HVZ88_21780 ENOG4108SER Transposase HVZ88_21785 ENOG4108NKV transcriptional regulator HVZ88_21800 ENOG4107XAN XdhC and CoxI family HVZ88_21805 ENOG4105C7W Xanthine dehydrogenase HVZ88_21810 ENOG4105DIP Molybdopterin dehydrogenase FAD-binding HVZ88_21815 ENOG4107XKX isoquinoline 1-oxidoreductase, alpha subunit HVZ88_21820 ENOG4105R3P Inner membrane protein yagU HVZ88_21825 ENOG4105PI0 Ferredoxin HVZ88_21830 ENOG4108UD7 cell wall organization HVZ88_21835 ENOG4106PYX Receptor HVZ88_21840 ENOG4108N3D putative enzyme HVZ88_21850 ENOG4108GWT fimbrillin MatB HVZ88_21855 ENOG4106JB4 Represses expression of the flagellar master operon flhDC, and consequently prevents flagellum biosynthesis and motility. Acts by binding to the regulatory region of the flhDC operon HVZ88_21895 ENOG4108KBJ Inner membrane protein YkgB HVZ88_21900 ENOG41066GK UPF0379 protein ykgI HVZ88_21905 ENOG4107QN2 dihydrolipoyl dehydrogenase HVZ88_21910 ENOG4108K01 transcriptional regulator HVZ88_21915 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) HVZ88_21920 ENOG4107QR9 Iron-sulfur cluster binding protein HVZ88_21925 ENOG4108ZZK Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source (By similarity) HVZ88_21935 ENOG4105CZ6 Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine (By similarity) HVZ88_21940 ENOG4105C26 Dehydrogenase HVZ88_21945 ENOG4108MHR Repressor involved in choline regulation of the bet genes (By similarity) HVZ88_21950 ENOG4105C94 Transporter HVZ88_21960 ENOG4105BZU Histidine kinase HVZ88_21965 ENOG4108NUU Transcriptional regulator HVZ88_21970 ENOG4105SZ2 membrAne HVZ88_21975 ENOG4107SNB ankyrin repeat protein YahD HVZ88_21980 ENOG4105N16 Protein of unknown function (DUF2877) HVZ88_21985 ENOG4107R1Q Membrane protein FdrA HVZ88_21990 ENOG4107REC cytoplasmic protein HVZ88_22000 ENOG4105C5B carbamate kinase HVZ88_22005 ENOG4105DZC cytosine deaminase HVZ88_22010 ENOG4105DQ4 alcohol dehydrogenase HVZ88_22025 ENOG4105E82 cytochrome subunit of dehydrogenase HVZ88_22030 ENOG4105TDT uncharacterized protein yahO HVZ88_22035 ENOG4108JU7 Transcriptional regulator HVZ88_22040 ENOG4105CR4 methylisocitrate lyase HVZ88_22045 ENOG4105BZN citrate synthase HVZ88_22050 ENOG4105DXD 2-methylcitrate dehydratase HVZ88_22055 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) HVZ88_22060 ENOG4105DQW permease for cytosine purines, uracil, thiamine, allantoin HVZ88_22065 ENOG4105DZC cytosine deaminase HVZ88_22070 ENOG4105DND Transcriptional regulator HVZ88_22075 ENOG4107B2H carbonic anhydrase HVZ88_22080 ENOG4108V7B Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide (By similarity) HVZ88_22085 ENOG4105DJ2 Major Facilitator Superfamily HVZ88_22090 ENOG4108UW5 maltose o-acetyltransferase HVZ88_22095 ENOG4105U0F oligosaccharide H symporter, major facilitator superfamily (MFS) HVZ88_22100 ENOG4105CNT hydrolase family 2 HVZ88_22105 ENOG4105ETE Transcriptional regulator (LacI family HVZ88_22110 ENOG4108K2P TRANSCRIPTIONal HVZ88_22115 ENOG4105E2Q 3-(3-hydroxy-phenyl)propionate hydroxylase HVZ88_22125 ENOG4106HB6 Alpha beta hydrolase HVZ88_22130 ENOG4105IKQ hydratase HVZ88_22145 ENOG4108SC4 )-transporter HVZ88_22150 ENOG4105IUQ nucleoprotein polynucleotide-associated enzyme HVZ88_22155 ENOG4105C4W S-formylglutathione hydrolase HVZ88_22170 ENOG4105SRB Uncharacterized protein yaiO HVZ88_22180 ENOG4108PBI Polysaccharide metabolism HVZ88_22185 ENOG4107W19 lmbE family HVZ88_22190 ENOG4106FTQ Taurine ABC transporter, periplasmic HVZ88_22195 ENOG4108ETV ABC transporter HVZ88_22200 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component HVZ88_22205 ENOG4105E2B Taurine dioxygenase HVZ88_22210 ENOG4105D52 delta-aminolevulinic acid dehydratase HVZ88_22215 ENOG4108NSE outer membrane autotransporter barrel HVZ88_22230 ENOG4108PNB DNA-binding transcriptional regulator HVZ88_22235 ENOG4107R6D beta-lactam binding protein AmpH HVZ88_22240 ENOG4108DQG in Escherichia coli SbmA is involved in uptake of microcin J25 HVZ88_22245 ENOG4107QS8 (LipO)protein HVZ88_22250 ENOG4105FR5 inner membrane protein YaiY HVZ88_22255 ENOG4105UNH Membrane HVZ88_22260 ENOG4105CPF Cell wall formation (By similarity) HVZ88_22275 ENOG4105G6Z alkaline phosphatase HVZ88_22280 ENOG4105VIF phosphate starvation-inducible protein HVZ88_22285 ENOG4105BZU Histidine kinase HVZ88_22290 ENOG4105II7 pyrroline-5-carboxylate reductase HVZ88_22295 ENOG4108UPT UPF0178 protein HVZ88_22305 ENOG4105SS3 HVZ88_22310 ENOG4105HBA AroM protein HVZ88_22335 ENOG4105DKQ ROK family HVZ88_22340 ENOG4105F27 Major Facilitator HVZ88_22345 ENOG4105EYH Exonuclease HVZ88_22350 ENOG4107RH8 nuclease SbcCD subunit D HVZ88_22355 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HVZ88_22360 ENOG4105BZU Histidine kinase HVZ88_22365 ENOG4105CWM branched-chain amino acid transport system II carrier protein HVZ88_22370 ENOG4105C85 amino acid HVZ88_22375 ENOG4107R28 alpha amylase, catalytic region HVZ88_22380 ENOG4108ZYK Acyl carrier protein phosphodiesterase HVZ88_22395 ENOG4105VIE preprotein translocase, subunit YajC HVZ88_22400 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) HVZ88_22405 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) HVZ88_22410 ENOG4105N1F Hnh endonuclease HVZ88_22415 ENOG4105DRB nucleoside-specific channel-forming protein HVZ88_22420 ENOG4108KIC (LipO)protein HVZ88_22430 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) HVZ88_22435 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) HVZ88_22445 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) HVZ88_22450 ENOG4108ZAI phosphatidylglycerophosphatase a HVZ88_22455 ENOG4105CPC Aldo Keto reductase HVZ88_22460 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) HVZ88_22465 ENOG4105CTB Polyprenyl synthetase HVZ88_22475 ENOG4105D8I Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity) HVZ88_22480 ENOG4107S0N DJ-1 family HVZ88_22485 ENOG4108JZF Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) HVZ88_22495 ENOG4107RDB Major Facilitator HVZ88_22505 ENOG41090KH cytochrome o ubiquinol oxidase (subunit iv) HVZ88_22510 ENOG4105CCU oxidase (Subunit III) HVZ88_22515 ENOG4105BZ9 Cytochrome C oxidase, subunit I HVZ88_22520 ENOG4105E2S oxidase) subunit II HVZ88_22525 ENOG4105EYM Major Facilitator superfamily HVZ88_22530 ENOG4105IEY (LipO)protein HVZ88_22535 ENOG4105M85 Bola protein HVZ88_22555 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) HVZ88_22560 ENOG4105K70 DNA-binding protein HVZ88_22565 ENOG4105EIN peptidylprolyl cis-trans isomerase HVZ88_22570 ENOG41083P1 competence protein ComEA helix-hairpin-helix repeat protein HVZ88_22575 ENOG4108TGP Thioesterase superfamily protein HVZ88_22580 ENOG4105FD2 Catalyzes the ATP-dependent conversion of 7-carboxy-7- deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)) (By similarity) HVZ88_22585 ENOG4108NFA extracellular solute-binding protein HVZ88_22590 ENOG4108AZI Catalyzes the hydrolysis of 4-amino-2-methyl-5- hydroxymethylpyrimidine pyrophosphate (HMP-PP) to 4-amino-2- methyl-5-hydroxymethylpyrimidine phosphate (HMP-P) (By similarity) HVZ88_22595 ENOG4108XM1 transcriptional regulator AsnC family HVZ88_22600 ENOG4105BZ1 (ABC) transporter HVZ88_22605 ENOG4105BZ1 (ABC) transporter HVZ88_22610 ENOG4108YZA Nitrogen regulatory protein pii HVZ88_22615 ENOG4105BZU Histidine kinase HVZ88_22620 ENOG4105C29 acyl-CoA thioesterase HVZ88_22625 ENOG4108MNP Glycoprotein polysaccharide metabolism HVZ88_22630 ENOG41080UX Methyltransferase HVZ88_22640 ENOG4105KCV RNA signal recognition particle 4.5S RNA HVZ88_22645 ENOG41066DG (EAL) domain protein HVZ88_22650 ENOG4105GSJ Inner membrane protein ylaC HVZ88_22655 ENOG4108UW5 maltose o-acetyltransferase HVZ88_22660 ENOG4105KF5 hemolysin expression-modulating protein HVZ88_22665 ENOG4108UKR Biofilm formation regulator YbaJ HVZ88_22670 ENOG4105BZS acriflavin resistance protein HVZ88_22675 ENOG4105C1P efflux transporter, rnd family, mfp subunit HVZ88_22680 ENOG4107XI7 Tetr family transcriptional regulator HVZ88_22685 ENOG4105EGS Mechanosensitive ion channel HVZ88_22690 ENOG4106428 Protein of unknown function (DUF2496) HVZ88_22695 ENOG4108URS primosomal replication protein n'' HVZ88_22700 ENOG4105WD1 Membrane HVZ88_22710 ENOG4107QMP dna polymerase iii subunits gamma and tau HVZ88_22735 ENOG4105CFX Catalyzes the ferrous insertion into protoporphyrin IX (By similarity) HVZ88_22745 ENOG4107RE1 Inosine-guanosine kinase HVZ88_22750 ENOG4105CKD glutathione-regulated potassium-efflux system protein HVZ88_22755 ENOG4105EU0 Major facilitator Superfamily HVZ88_22760 ENOG4105CGH 5'-nucleotidase HVZ88_22765 ENOG4108Z66 YbaK ebsC protein HVZ88_22770 ENOG4105MBR gumn family HVZ88_22775 ENOG41081XE plasmid maintenance system antidote protein, xre family HVZ88_22780 ENOG4105C59 p-type ATPase HVZ88_22785 ENOG4105CSV Glutaminase HVZ88_22790 ENOG4107RY6 amino acid HVZ88_22795 ENOG4108Z6Z Transcriptional regulator HVZ88_22800 ENOG4105G5H Membrane HVZ88_22805 ENOG4107QX8 SPFH domain, Band 7 family protein HVZ88_22810 ENOG41083J0 (ABC) transporter HVZ88_22815 ENOG4105C4B ABC transporter, permease HVZ88_22820 ENOG4107QR8 Thioredoxin HVZ88_22825 ENOG4105E1F short-chain dehydrogenase reductase HVZ88_22830 ENOG4108UJV acyl-CoA thioesterase i HVZ88_22835 ENOG4108I0Y (ABC) transporter HVZ88_22840 ENOG4105CV6 ABC transporter, permease HVZ88_22845 ENOG4105CNA YD repeat protein HVZ88_22875 ENOG4105CR7 Catalyzes the transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA (By similarity) HVZ88_22880 ENOG4107653 Transcriptional regulator HVZ88_22890 ENOG4108N16 Negative regulator of allantoin and glyoxylate utilization operons. Binds to the gcl promoter and to the allS- allA intergenic region HVZ88_22895 ENOG41060W2 glyoxylate carboligase HVZ88_22900 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) HVZ88_22905 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase HVZ88_22910 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease HVZ88_22915 ENOG4105CD3 dihydroorotase HVZ88_22920 ENOG4105DTE Xanthine uracil vitamin C permease HVZ88_22925 ENOG4105BZW Glycerate kinase HVZ88_22930 ENOG4105S0E allantoin catabolism protein HVZ88_22935 ENOG4105CE7 Amidase, hydantoinase carbamoylase family HVZ88_22940 ENOG4105DG4 malate L-lactate dehydrogenase HVZ88_22945 ENOG4107R1Q Membrane protein FdrA HVZ88_22950 ENOG4107REC cytoplasmic protein HVZ88_22955 ENOG4105G5A Protein of unknown function (DUF2877) HVZ88_22960 ENOG4105C5B carbamate kinase HVZ88_22965 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit HVZ88_22970 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) HVZ88_22980 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) HVZ88_22990 ENOG4105S2T inner membrane protein YbcI HVZ88_22995 ENOG4105WQ3 Rna-binding protein HVZ88_23000 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) HVZ88_23005 ENOG4108WDE Fimbrial protein HVZ88_23010 ENOG4108AF8 Chaperone HVZ88_23015 ENOG4105CW0 outer membrane usher protein HVZ88_23020 ENOG4108M66 Involved in regulation of length and mediation of adhesion of SfmA fimbriae (but not necessary for the production of fimbriae). Seems to be mannose binding adhesin (By similarity) HVZ88_23025 ENOG4108ZI2 Fimbrial protein HVZ88_23030 ENOG4108Q9V regulatoR HVZ88_23060 ENOG4105CS6 Rhs element vgr protein HVZ88_23065 ENOG4105GR3 Histidine kinase HVZ88_23070 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HVZ88_23075 ENOG4105ENJ RND efflux system, outer membrane lipoprotein HVZ88_23080 ENOG410624V efflux system protein HVZ88_23085 ENOG4105EP1 Efflux transporter rnd family, mfp subunit HVZ88_23090 ENOG4108IJF Heavy metal efflux pump, CzcA HVZ88_23095 ENOG4105C85 amino acid HVZ88_23100 ENOG4105CUY Mechanosensitive ion channel HVZ88_23105 ENOG4108RCM Nitroreductase HVZ88_23110 ENOG4105MSB protein, conserved in bacteria HVZ88_23115 ENOG4105WQ6 Membrane HVZ88_23120 ENOG4106KXD ATP-dependent carboxylate-amine ligase (By similarity) HVZ88_23130 ENOG4107635 Hok Gef family protein HVZ88_23135 ENOG4108SER Transposase HVZ88_23140 ENOG4108TSE Transferase HVZ88_23145 ENOG4107RNH Outer membrane receptor FepA HVZ88_23150 ENOG4105E93 esterase HVZ88_23155 ENOG41085A6 mbth domain-containing protein HVZ88_23160 ENOG4105C0W non-ribosomal peptide synthetase HVZ88_23165 ENOG4108QY5 Ferric enterobactin transport protein HVZ88_23170 ENOG4105E0A ABC, transporter HVZ88_23175 ENOG4105TVJ transport system, permease HVZ88_23180 ENOG4105DQ5 transport system permease protein HVZ88_23190 ENOG4105PEC Iron-enterobactin transporter periplasmic binding protein HVZ88_23195 ENOG4105E4F Isochorismate synthase HVZ88_23200 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase HVZ88_23205 ENOG4105WQI isochorismatase HVZ88_23210 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase HVZ88_23215 ENOG4108TZA Required for optimal enterobactin synthesis. Acts as a proofreading enzyme that prevents EntB misacylation by hydrolyzing the thioester bound existing between EntB and wrongly charged molecules (By similarity) HVZ88_23220 ENOG4105D22 carbon starvation protein HVZ88_23225 ENOG4105VCD cytoplasmic protein HVZ88_23230 ENOG4107SCQ Iron-containing alcohol dehydrogenase HVZ88_23235 ENOG4105CHM Aminotransferase HVZ88_23240 ENOG4105GTN ParB Domain Protein Nuclease HVZ88_23245 ENOG4105BZV Phosphoadenosine phosphosulfate reductase HVZ88_23250 ENOG4105DQS Transcriptional regulator HVZ88_23255 ENOG4108KHN disulfide isomerase, thiol-disulfide oxidase HVZ88_23260 ENOG4105D3R alkyl hydroperoxide reductase HVZ88_23265 ENOG4108JU3 Alkyl hydroperoxide reductase HVZ88_23270 ENOG4108U51 Universal stress protein HVZ88_23275 ENOG4105E2A Dehydrogenase HVZ88_23280 ENOG4105NXH GreA GreB family elongation factor HVZ88_23285 ENOG4105KTS ribonuclease HVZ88_23290 ENOG4107QPK )-transporter HVZ88_23305 ENOG4105CHY citrate lyase, alpha HVZ88_23310 ENOG4105CI0 Citrate lyase HVZ88_23320 ENOG4105DUA (citrate (pro-3S)-lyase ligase HVZ88_23325 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism HVZ88_23330 ENOG4106YYS transcriptional regulatory protein HVZ88_23335 ENOG4105CEE C4-dicarboxylate transporter HVZ88_23340 ENOG41079UR PagP is required both for biosynthesis of hepta-acylated lipid A species containing palmitate and for resistance to cationic antimicrobial peptides (CAMPs). It catalyzes the transfer of a palmitate chain (16 0) from the sn-1 position of a glycerophospholipid to the free hydroxyl group of the (R)-3- hydroxymyristate chain at position 2 of lipid A (endotoxin) (By similarity) HVZ88_23360 ENOG410607N Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatE shares overlapping functions with TatA (By similarity) HVZ88_23370 ENOG41064T2 transcriptional regulator, lysR family HVZ88_23385 ENOG4105DZ1 carboxypeptidase HVZ88_23390 ENOG4105K6T rare lipoprotein A HVZ88_23395 ENOG4105CNI cell division protein FtsW HVZ88_23400 ENOG4105CJN penicillin-binding protein HVZ88_23410 ENOG4105KEM Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) HVZ88_23415 ENOG4108TGR phosphatase HVZ88_23425 ENOG4105DJF DNA polymerase III, delta' subunit HVZ88_23440 ENOG4107PAI alpha helical protein HVZ88_23445 ENOG4105EUU Sel1 domain protein repeat-containing protein HVZ88_23450 ENOG41069CF Protein of unknown function (DUF1266) HVZ88_23455 ENOG4105QFC Hsc56 co-chaperone of HscC HVZ88_23460 ENOG4107JFD Sel1 repeat HVZ88_23465 ENOG41069CF Protein of unknown function (DUF1266) HVZ88_23470 ENOG4105QFC Hsc56 co-chaperone of HscC HVZ88_23475 ENOG4105F7F Chaperone HVZ88_23485 ENOG4105CDA abc transporter atp-binding protein HVZ88_23490 ENOG4105DRP amino acid AbC transporter HVZ88_23495 ENOG4105EAD ABC transporter HVZ88_23500 ENOG4107RP9 extracellular solute-binding protein, family 3 HVZ88_23505 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) HVZ88_23510 ENOG4108JU5 Magnesium and cobalt efflux protein HVZ88_23520 ENOG4105C9A Phoh family HVZ88_23530 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family HVZ88_23570 ENOG4105CAQ asparagine synthetase HVZ88_23575 ENOG4105D4U had-superfamily hydrolase, subfamily iia HVZ88_23580 ENOG4105E2R ROK family HVZ88_23585 ENOG4105CE4 GlcNAc 6-P deacetylase HVZ88_23595 ENOG4105CI1 PTS System HVZ88_23610 ENOG4105GX6 (LipO)protein HVZ88_23615 ENOG41090R7 Ferric uptake HVZ88_23625 ENOG4105MHQ Low-potential electron donor to a number of redox enzymes (By similarity) HVZ88_23630 ENOG4105NNH LexA regulated protein HVZ88_23635 ENOG4105EV9 Alpha Beta Hydrolase HVZ88_23640 ENOG4107CDU Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated (By similarity) HVZ88_23645 ENOG4107QIX Phosphoglucomutase (EC 5.4.2.2 HVZ88_23665 ENOG4105D5Q Arginine ornithine antiporter HVZ88_23670 ENOG4105CXN decarboxylase HVZ88_23680 ENOG4105EEX Two component transcriptional regulator (Winged helix family HVZ88_23685 ENOG4105C08 Histidine kinase HVZ88_23690 ENOG4108R80 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity) HVZ88_23695 ENOG4105C8X One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) HVZ88_23710 ENOG4105XIQ Protein of unknown function (DUF2517) HVZ88_23715 ENOG4105CNA YD repeat protein HVZ88_23720 ENOG41079JQ Membrane HVZ88_23725 ENOG4105CNA YD repeat protein HVZ88_23730 ENOG4106R09 HVZ88_23750 ENOG4107SEY Conserved Protein HVZ88_23755 ENOG4105CVP deoxyribo-dipyrimidine photolyase HVZ88_23760 ENOG4105DUX Transporter HVZ88_23765 ENOG4107QNR UPF0135 protein HVZ88_23770 ENOG4105P4J Allophanate hydrolase, subunit 1 HVZ88_23775 ENOG4107R7A Allophanate hydrolase subunit 2 HVZ88_23780 ENOG4105E7W lamb ycsf family protein HVZ88_23790 ENOG4108KK1 membrane protein AbrB duplication HVZ88_23795 ENOG4108MY7 Fimbrial HVZ88_23800 ENOG4108TTM chaperone HVZ88_23805 ENOG4106PG1 outer membrane usher protein HVZ88_23810 ENOG4106UBK fimbrial-like adhesin protein HVZ88_23815 ENOG4105BZN citrate synthase HVZ88_23825 ENOG4108UTY succinate dehydrogenase, cytochrome b556 subunit HVZ88_23830 ENOG4105N1I succinate dehydrogenase, hydrophobic membrane anchor protein HVZ88_23835 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) HVZ88_23840 ENOG4105E33 succinate dehydrogenase HVZ88_23845 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 HVZ88_23850 ENOG4105C7S Dehydrogenase HVZ88_23860 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha HVZ88_23865 ENOG4105FDP GntR family transcriptional regulator HVZ88_23870 ENOG4105DM4 PTS System HVZ88_23875 ENOG4105C8I hydrolase, family 38 HVZ88_23880 ENOG4105C4M (Ubiquinol oxidase) subunit I HVZ88_23885 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii HVZ88_23895 ENOG4105KJB cyd operon protein YbgE HVZ88_23900 ENOG4107YD3 Thioesterase HVZ88_23905 ENOG4105E02 MotA TolQ exbB proton channel HVZ88_23915 ENOG4108Z82 Cell envelope integrity inner membrane protein TolA HVZ88_23925 ENOG4105KCK Peptidoglycan-associated lipoprotein HVZ88_23930 ENOG4105UFD tol-pal system protein YbgF HVZ88_23970 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) HVZ88_23975 ENOG4106Z1T Nicotinamide Mononucleotide Transporter HVZ88_23980 ENOG4105PGM cation diffusion facilitator family transporter HVZ88_23985 ENOG4105JND homeobox protein HVZ88_23990 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) HVZ88_24000 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) HVZ88_24010 ENOG4105F0Z galactose-1-phosphate uridylyltransferase HVZ88_24015 ENOG4105CMR udp-glucose 4-epimerase HVZ88_24020 ENOG4105DKW ABC transporter HVZ88_24025 ENOG4105F4R Transcriptional regulator mode HVZ88_24035 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein HVZ88_24040 ENOG4105E0C molybdate abc transporter HVZ88_24045 ENOG4105CGB Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system (By similarity) HVZ88_24050 ENOG4108K4B hydrolase HVZ88_24060 ENOG4105F04 LysR family Transcriptional regulator HVZ88_24065 ENOG4105C7F AcnD-accessory protein PrpF HVZ88_24070 ENOG4107QPK )-transporter HVZ88_24075 ENOG4107QM5 aconitate hydratase HVZ88_24080 ENOG4105NBR Pectinesterase HVZ88_24085 ENOG4108V1U phospholipid-binding protein HVZ88_24090 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) HVZ88_24100 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) HVZ88_24105 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) HVZ88_24110 ENOG4105E78 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) HVZ88_24120 ENOG4105CHW UPF0052 protein HVZ88_24130 ENOG4108RIR Molybdenum cofactor biosynthesis protein HVZ88_24140 ENOG4105M00 molybdopterin converting factor, subunit 1 HVZ88_24145 ENOG4108ZAF Molybdopterin HVZ88_24150 ENOG4105HFZ Membrane HVZ88_24155 ENOG410733J conserved inner membrane protein HVZ88_24160 ENOG4107UXM Membrane HVZ88_24165 ENOG4105DZQ phospholipase D Transphosphatidylase HVZ88_24170 ENOG4105X23 Endonuclease Exonuclease phosphatase HVZ88_24175 ENOG4105I9U inner membrane protein ybhQ HVZ88_24180 ENOG4107QWP ABC-2 type transporter HVZ88_24185 ENOG4107QWP ABC-2 type transporter HVZ88_24190 ENOG4105CJ1 ABC, transporter HVZ88_24200 ENOG4107MVR Transcriptional regulator HVZ88_24205 ENOG4105C1J atp-dependent rna helicase HVZ88_24210 ENOG4108UV1 cellular component movement HVZ88_24215 ENOG4105DVT helicase HVZ88_24220 ENOG4108MTB glycosyl transferase family HVZ88_24225 ENOG4105DG4 malate L-lactate dehydrogenase HVZ88_24230 ENOG4105VR4 UPF0379 protein ybiJ HVZ88_24235 ENOG4105KSC Transcriptional regulator, TraR DksA family HVZ88_24245 ENOG4108IU3 tonb-dependent siderophore receptor HVZ88_24250 ENOG4105ZY9 UPF0379 protein ybiM HVZ88_24260 ENOG4105D8X mechanosensitive ion channel HVZ88_24265 ENOG4105CDA abc transporter atp-binding protein HVZ88_24270 ENOG4105E5Q amino acid AbC transporter HVZ88_24275 ENOG4107R0W ABC transporter HVZ88_24285 ENOG4107AQZ Membrane HVZ88_24295 ENOG4108T1M outer membrane protein x HVZ88_24300 ENOG4108I6E Sulfatase HVZ88_24310 ENOG4105KST dependent repressor HVZ88_24315 ENOG4105F4P )-transporter HVZ88_24320 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein HVZ88_24325 ENOG4105C5H ABC transporter HVZ88_24330 ENOG41072TH Protein of unknown function (DUF1479) HVZ88_24335 ENOG4108HCJ Hydrolase HVZ88_24345 ENOG4105F1A Pyruvate formate-lyase HVZ88_24350 ENOG4107T9Z Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) HVZ88_24355 ENOG4105D06 uba thif-type nad fad binding protein HVZ88_24360 ENOG4105CVM Molybdenum cofactor synthesis domain protein HVZ88_24365 ENOG4105D44 asparaginase HVZ88_24370 ENOG4108JQ6 ABC transporter HVZ88_24375 ENOG4105DEF Extracellular solute-binding protein, family 5 HVZ88_24385 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HVZ88_24390 ENOG4105BZU Histidine kinase HVZ88_24395 ENOG41064RH membrane protein YliF HVZ88_24405 ENOG4105UFT Represses biofilm formation in M9C glu and LB glu media but not in M9C and LB media. Seems to act as a global regulator of several genes involved in catabolite repression and stress response and regulation of the uptake and export of signaling pathways. Could be involved the regulation of indole as well as uptake and export of AI-2 through a cAMP-dependent pathway HVZ88_24410 ENOG4105D8V Glucose sorbosone dehydrogenase HVZ88_24415 ENOG4108TGY Glutathione S-transferase HVZ88_24420 ENOG4105DZ1 carboxypeptidase HVZ88_24425 ENOG4107FB0 transcriptional regulator DeoR family HVZ88_24430 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase HVZ88_24435 ENOG4107QF7 multi-drug HVZ88_24445 ENOG4108HCJ Hydrolase HVZ88_24450 ENOG4106UW1 Major Facilitator superfamily HVZ88_24455 ENOG4108RFG Tetr family transcriptional regulator HVZ88_24465 ENOG4105GWF inner membrane protein YbjM HVZ88_24470 ENOG41090BQ Glutaredoxin HVZ88_24475 ENOG4105X20 member of the soxRS regulon which mediates in part the increased levels of superoxide in response to oxidative stress HVZ88_24480 ENOG4108DBC nitroreductase HVZ88_24490 ENOG4108RMJ sensory transduction regulator HVZ88_24495 ENOG4107RUE extracellular solute-binding protein family 1 HVZ88_24500 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HVZ88_24505 ENOG4105F38 ABC transporter, permease HVZ88_24510 ENOG4105D38 putrescine abc transporter HVZ88_24515 ENOG4105RBQ inner membrane protein ybjO HVZ88_24520 ENOG4107SFS Catalyzes the formation of 5-methyl-uridine at position 747 (m5U747) in 23S rRNA (By similarity) HVZ88_24525 ENOG4106TNF Periplasmic binding protein HVZ88_24530 ENOG4105DMR ABC, transporter HVZ88_24535 ENOG4105GBT ABC transporter HVZ88_24540 ENOG4106PMH Extracellular solute-binding protein family 3 HVZ88_24545 ENOG4105E5Z arginine transporter ATP-binding subunit HVZ88_24550 ENOG41064MM (LipO)protein HVZ88_24560 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase HVZ88_24565 ENOG4107VBM 3-beta hydroxysteroid dehydrogenase isomerase HVZ88_24570 ENOG4105CGD Nad-dependent epimerase dehydratase HVZ88_24575 ENOG4105C5W Aldolase HVZ88_24580 ENOG4105C7K acetolactate synthase HVZ88_24585 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) HVZ88_24595 ENOG4105DWU Membrane HVZ88_24605 ENOG4105CPB ATP-dependent endonuclease of the OLD family HVZ88_24610 ENOG4108MJ5 VirK protein HVZ88_24615 ENOG4105DJY efflux transporter, rnd family, mfp subunit HVZ88_24620 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) HVZ88_24625 ENOG4105VEQ Cold shock protein HVZ88_24635 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit HVZ88_24645 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) HVZ88_24655 ENOG4108JJ8 (ABC) transporter HVZ88_24660 ENOG4108JJ9 ABC, transporter HVZ88_24665 ENOG4105C3M thioredoxin reductase HVZ88_24675 ENOG4105CNU cell division protein FtsK HVZ88_24685 ENOG4105D1H recombination factor protein RarA HVZ88_24695 ENOG4107QY8 reductase HVZ88_24700 ENOG4105QAX Iron-sulfur HVZ88_24705 ENOG4107KGK dmso reductase anchor subunit HVZ88_24710 ENOG4105CHJ isochorismatase hydrolase HVZ88_24720 ENOG4105E5D amino acid HVZ88_24725 ENOG410642W LysR family Transcriptional regulator HVZ88_24730 ENOG4108X0B nad(p)h dehydrogenase (quinone) HVZ88_24735 ENOG4105F1A Pyruvate formate-lyase HVZ88_24740 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HVZ88_24805 ENOG4105D5G Transposase HVZ88_24840 ENOG41073YN Protein of unknown function (DUF1380) HVZ88_24910 ENOG4105T58 Dithiol-disulfide isomerase HVZ88_24925 ENOG4105KDP XRE family HVZ88_24955 ENOG4105K4U addiction module toxin, RelE StbE family HVZ88_25035 ENOG4105CZX twitching motility protein HVZ88_25050 ENOG4105K5T PilT protein HVZ88_25170 ENOG4105VT3 DNA binding domain protein, excisionase family HVZ88_25195 ENOG4105H38 Membrane HVZ88_25235 ENOG4105KDP XRE family HVZ88_25335 ENOG4105CZX twitching motility protein HVZ88_25350 ENOG4105K5T PilT protein