locus-tag class description HV181_00010 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) HV181_00020 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HV181_00025 ENOG4105VP5 Bacterial protein of unknown function (DUF937) HV181_00030 ENOG410667J hydrolase HV181_00035 ENOG410657R replicase EC 2.7 HV181_00040 ENOG4105EMF GntR family transcriptional regulator HV181_00045 ENOG4105EI3 2-dehydro-3-deoxygalactonokinase EC 2.7.1.58 HV181_00050 ENOG4108RTU Aldolase HV181_00060 ENOG4105DJB Major Facilitator Superfamily HV181_00070 ENOG4105D99 atp gtp-binding protein HV181_00075 ENOG4105R2A (LipO)protein HV181_00095 ENOG4105FDP GntR family transcriptional regulator HV181_00100 ENOG4105CI1 PTS System HV181_00115 ENOG4108AHD Transcriptional regulator HV181_00120 ENOG4107RUZ Sss sodium solute transporter superfamily HV181_00125 ENOG4105CBG Sulfatase HV181_00130 ENOG4106DRA Inner membrane protein YidI HV181_00135 ENOG4105VG5 Membrane HV181_00140 ENOG4105JP4 Inner membrane protein yidG HV181_00145 ENOG4105J13 transcriptional regulator HV181_00150 ENOG4105E5M Multidrug resistance protein D HV181_00165 ENOG4105C7K acetolactate synthase HV181_00170 ENOG4105M71 acetolactate synthase 1 regulatory subunit HV181_00175 ENOG4108KX4 response regulator HV181_00180 ENOG4105BZU Histidine kinase HV181_00185 ENOG4105CXY transporter HV181_00190 ENOG4105CXY transporter HV181_00200 ENOG4105C7N Xanthine uracil vitamin C permease HV181_00205 ENOG4108SAJ Protein of unknown function (DUF1198) HV181_00215 ENOG4105T8A Uncharacterized protein YicS HV181_00220 ENOG4105D01 (LipO)protein HV181_00225 ENOG4108UZ3 Transporter HV181_00230 ENOG4105S8Q sugar efflux transporter HV181_00245 ENOG4105CT4 transporter HV181_00250 ENOG4105CJQ hydrolase, family 31 HV181_00255 ENOG4105JV1 AsmA family HV181_00260 ENOG4105C2W permease HV181_00265 ENOG4105D6U Sodium Glutamate Symporter HV181_00275 ENOG4105CB5 ATP-dependent DNA helicase recG HV181_00280 ENOG4105FE8 tRNA (Guanosine-2'-O-)-methyltransferase HV181_00285 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) HV181_00295 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) HV181_00305 ENOG4105EN6 Membrane HV181_00310 ENOG4105F5P DNA-damage-inducible protein d HV181_00315 ENOG4105DSJ YicC domain protein HV181_00330 ENOG4107RRE RNA-directed DNA polymerase HV181_00340 ENOG4108Z1K This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) HV181_00345 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase HV181_00355 ENOG4105KDC 50s ribosomal protein l28 HV181_00375 ENOG4105D8A 3-Deoxy-D-manno-octulosonic-acid transferase HV181_00380 ENOG4105DKP glycosyl transferase, family 9 HV181_00385 ENOG4107RJ7 Glycosyl transferase (Group 1 HV181_00390 ENOG4107543 (lipo)polysaccharide HV181_00395 ENOG4106AH0 Glycosyl Transferase HV181_00400 ENOG4105X1N Glycosyl transferase family 8 HV181_00410 ENOG4105X1N Glycosyl transferase family 8 HV181_00415 ENOG4105K64 Glycosyl transferase, family 2 HV181_00420 ENOG41068PG O-Antigen polymerase HV181_00425 ENOG4105D16 lipopolysaccharide heptosyltransferase i HV181_00430 ENOG4105XA0 heptosyltransferase ii HV181_00440 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) HV181_00450 ENOG4105K64 Glycosyl transferase, family 2 HV181_00455 ENOG4105PXI polysaccharide deacetylase HV181_00460 ENOG41063SB peptidase HV181_00470 ENOG4107YZP Rhodanese domain protein HV181_00475 ENOG4105VW4 glutaredoxin 3 HV181_00490 ENOG4105D7W serine acetyltransferase HV181_00495 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) HV181_00505 ENOG41073TP transcriptional regulator HV181_00510 ENOG4105DAA L-lactate HV181_00515 ENOG4105EUR Domain-Containing protein HV181_00520 ENOG4108WY4 inner membrane lipoprotein HV181_00525 ENOG4108YYI Protein of unknown function (DUF2810) HV181_00535 ENOG4105E61 Mannitol repressor protein HV181_00545 ENOG4105CTS PTS system mannitol-specific HV181_00550 ENOG4105FP6 Protein of unknown function (DUF3302) HV181_00555 ENOG4105EFX secretion protein, HlyD family HV181_00580 ENOG4105NUP lyase containing HEAT-repeat HV181_00585 ENOG4105CNA YD repeat protein HV181_00590 ENOG4108U78 Glutathione S-transferase HV181_00600 ENOG4105EM7 Selenocysteine-specific translation elongation factor HV181_00605 ENOG4105C0A alcohol dehydrogenase HV181_00610 ENOG4105C26 Dehydrogenase HV181_00620 ENOG4105KK7 inner membrane protein YiaW HV181_00625 ENOG4105EFX secretion protein, HlyD family HV181_00630 ENOG4108Q2M Transcriptional regulator HV181_00635 ENOG4105GNX MltA-interacting MipA family protein HV181_00645 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase HV181_00650 ENOG41064BZ L-xylulose 5-phosphate 3-epimerase HV181_00655 ENOG4105H6Q decarboxylase HV181_00660 ENOG4105CMG Carbohydrate kinase HV181_00665 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit HV181_00670 ENOG4105CG6 trap dicarboxylate transporter dctm subunit HV181_00675 ENOG4105XDZ Tripartite ATP-independent periplasmic transporter HV181_00680 ENOG4108R66 Conserved Protein HV181_00690 ENOG4105J4Q Transcriptional regulator HV181_00695 ENOG4108XIB electron transport protein ysaA HV181_00700 ENOG4105JKW Valine--pyruvate aminotransferase HV181_00705 ENOG4107T9C Alpha amylase catalytic region HV181_00710 ENOG4108UR8 BAX protein HV181_00715 ENOG4105T16 Transcriptional regulator (AraC family) HV181_00720 ENOG4108HWW ABC transporter HV181_00730 ENOG4105DFW ABC transporter HV181_00740 ENOG4105CMG Carbohydrate kinase HV181_00745 ENOG410688U Inner membrane protein yiaB HV181_00750 ENOG4108Z12 YiaAB two helix domain-containing protein HV181_00755 ENOG4105MEV Acyl-transferase HV181_00775 ENOG41060TC Hok gef cell toxic protein HV181_00785 ENOG4105MVF Transcriptional regulator HV181_00790 ENOG4106JH6 (LipO)protein HV181_00800 ENOG4108ZG0 Ompa motb domain protein HV181_00805 ENOG4107QY8 reductase HV181_00810 ENOG4105HNP -acetyltransferase HV181_00815 ENOG4108R3E Dna-3-methyladenine glycosylase i HV181_00820 ENOG4105EAX Putative lipase HV181_00825 ENOG4105FCD Major Facilitator HV181_00830 ENOG4105DIJ Phosphoethanolamine transferase HV181_00845 ENOG4105DEF Extracellular solute-binding protein, family 5 HV181_00850 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HV181_00855 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HV181_00860 ENOG4105C3U ABC transporter HV181_00865 ENOG4108JQ7 (ABC) transporter HV181_00870 ENOG4105C44 Serine transporter HV181_00895 ENOG4105D1V cellulose synthase operon protein YhjU HV181_00900 ENOG4105WQA Cellulose biosynthesis protein BcsF HV181_00905 ENOG4105U74 cellulose biosynthesis protein BcsE HV181_00910 ENOG410661M cytoplasmic protein HV181_00920 ENOG4107QZ7 Cellulose synthase catalytic subunit HV181_00925 ENOG4107EEX Cellulose synthase regulator protein HV181_00930 ENOG4105K2Z endo-1,4-d-glucanase (EC 3.2.1.4) HV181_00940 ENOG4105BZU Histidine kinase HV181_00950 ENOG4105CS0 peptidase HV181_00960 ENOG4105CMB EAL domain-containing protein HV181_00965 ENOG41066T0 asmA family HV181_00970 ENOG4105CSH Transporter HV181_00975 ENOG4107H3J ribonuclease HV181_00980 ENOG4105CBN LysR family transcriptional regulator HV181_00985 ENOG4106S2D Transcriptional regulator HV181_00995 ENOG4105CA0 peroxidase HV181_01000 ENOG4105CVK Glutamate decarboxylase HV181_01005 ENOG4108NKV transcriptional regulator HV181_01015 ENOG4105BZS acriflavin resistance protein HV181_01020 ENOG4105C1P efflux transporter, rnd family, mfp subunit HV181_01030 ENOG4106WJ0 Regulates the expression of several genes involved in acid resistance. Required for the expression of gadA and gadBC, among others, regardless of media or growth conditions. Binds directly to the 20 bp GAD box found in the control regions of both loci HV181_01035 ENOG4108YK4 Acid-resistance membrane protein HV181_01040 ENOG41060V2 Acid-resistance protein HV181_01045 ENOG4105XXV Acid-resistance protein HV181_01050 ENOG4105KT7 mgtC SapB transporter HV181_01060 ENOG4105Y4Z Outer Membrane Lipoprotein HV181_01070 ENOG4105K89 arsenate reductase HV181_01075 ENOG4107R5R arsenical pump membrane protein HV181_01080 ENOG4105KBH arsR family transcriptional regulator HV181_01090 ENOG4105DC8 reductase HV181_01095 ENOG4105D6S protein involved in catabolism of external DNA HV181_01100 ENOG4105DGW oligopeptidase A HV181_01110 ENOG4105DUX Transporter HV181_01125 ENOG4105CJ3 phosphate transporter HV181_01130 ENOG4105CBX hi0933 family HV181_01135 ENOG4107UNS conserved inner membrane protein HV181_01150 ENOG4105D0S secretion protein (HlyD HV181_01155 ENOG4105CJ1 ABC, transporter HV181_01160 ENOG4105CMI transporter HV181_01185 ENOG4106665 Part of the ABC transporter complex NikABCDE involved in nickel import. Responsible for energy coupling to the transport system (By similarity) HV181_01190 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HV181_01195 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HV181_01200 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein HV181_01205 ENOG4107YAK holo-(acyl carrier protein) synthase 2 HV181_01210 ENOG4105DSF transport protein HV181_01215 ENOG4105F9N Major Facilitator Superfamily HV181_01220 ENOG4108W1V Lipoprotein HV181_01225 ENOG4105EX9 Membrane HV181_01240 ENOG4107FS9 Membrane HV181_01250 ENOG4105MG3 Membrane HV181_01255 ENOG4106H78 methyltransferase HV181_01260 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) HV181_01265 ENOG4105CAK Cell division ATP-binding protein ftsE HV181_01270 ENOG4105CRP Part of the ABC transporter FtsEX involved in HV181_01275 ENOG4105DEK Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HV181_01280 ENOG4105CP9 extracellular ligand-binding receptor HV181_01295 ENOG4105U59 -acetyltransferase HV181_01300 ENOG4105CP9 extracellular ligand-binding receptor HV181_01305 ENOG4105C32 Amino acid ABC transporter (Permease) HV181_01310 ENOG4105CF8 branched-chain amino acid ABC transporter, permease HV181_01315 ENOG4105C0Z ABC transporter HV181_01320 ENOG4108IV0 ABC, transporter HV181_01325 ENOG4105BZ7 extracellular solute-binding protein family 1 HV181_01330 ENOG4105E4X binding-protein-dependent transport systems inner membrane Component HV181_01335 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component HV181_01340 ENOG4108IJ9 (ABC) transporter HV181_01345 ENOG4107T6V glycerophosphoryl diester phosphodiesterase HV181_01350 ENOG4105WC8 Conserved Protein HV181_01355 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) HV181_01360 ENOG4105WCN acetyltransferase HV181_01365 ENOG4105D9R oxidoreductase HV181_01370 ENOG4105C2I pirin domain protein HV181_01375 ENOG4105DIQ Transcriptional regulator HV181_01380 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family HV181_01385 ENOG4105C6Z Gluconate HV181_01390 ENOG41076UM multiple antibiotic resistance (MarC)-related protein HV181_01395 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) HV181_01420 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) HV181_01445 ENOG4105C6V Glycerol-3-phosphate dehydrogenase HV181_01460 ENOG4105E98 transcriptional regulator DeoR family HV181_01465 ENOG4105CYB regulatoR HV181_01470 ENOG4105E0Y RtcB Protein HV181_01485 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) HV181_01490 ENOG4107RTM 4-alpha-glucanotransferase (EC 2.4.1.25) HV181_01495 ENOG4105C6Z Gluconate HV181_01505 ENOG4105MJ2 Competence protein HV181_01515 ENOG4105DNE Transposase HV181_01525 ENOG4105CE1 Ferrous iron transport protein b HV181_01530 ENOG4105XFK Ferrous iron transport protein A HV181_01535 ENOG4105BZM domain protein HV181_01540 ENOG4108RRZ Transcription elongation factor GreB HV181_01550 ENOG4105E0F Histidine kinase HV181_01560 ENOG4108MAJ Membrane HV181_01570 ENOG4105VEJ Heat shock protein HV181_01575 ENOG4107Y3D HAD-superfamily hydrolase subfamily IA variant 3 HV181_01580 ENOG4105DQY intracellular growth attenuator HV181_01585 ENOG4107RK2 ADP-ribose diphosphatase NudE HV181_01590 ENOG4108JQC penicillin-binding protein 1A HV181_01595 ENOG4108U1Q Pilus assembly protein HV181_01600 ENOG41065NF Fimbrial assembly family protein HV181_01605 ENOG4105XPX DNA utilization protein HofO HV181_01610 ENOG4105ITY Required for the use of extracellular DNA as a nutrient HV181_01615 ENOG4105E4G Type IV pilus HV181_01630 ENOG4105EGB membrane protein DamX HV181_01635 ENOG4105DFE Dna adenine methylase HV181_01640 ENOG4105DJV ribulose-phosphate 3-epimerase HV181_01650 ENOG4105C31 Tryptophanyl-tRNA synthetase HV181_01655 ENOG4108M21 HV181_01660 ENOG4105RMW regulation of transcription, DNA-dependent HV181_01665 ENOG4108626 Racemase HV181_01670 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) HV181_01675 ENOG41080QX K07048 phosphotriesterase-related protein HV181_01680 ENOG4105MUZ Protein of unknown function DUF2620 HV181_01685 ENOG4106M0N transport system permease protein HV181_01690 ENOG4106PKC pyridoxal phosphate binding HV181_01695 ENOG4105FDP GntR family transcriptional regulator HV181_01700 ENOG4108KPW sugar kinase HV181_01705 ENOG4107Y0V Not clear, may be involved in an isomerization step HV181_01710 ENOG4107R1S catalyzes the conversion of fructoselysine 6-phosphate to glucose 6-phosphate and lysine HV181_01715 ENOG4107QHQ amino acid HV181_01720 ENOG4105VYH HV181_01730 ENOG4107V9H nitrite transporter HV181_01735 ENOG4105WZK nitrite reductase NADPH small subunit HV181_01740 ENOG4107QZF nitrite reductase NADPH large subunit HV181_01750 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) HV181_01760 ENOG4105MZU cell filamentation protein HV181_01765 ENOG4105DDQ anthranilate synthase HV181_01770 ENOG4105C8Y Acetylornithine aminotransferase HV181_01775 ENOG410613R integral membrane protein, YccS YhfK family HV181_01785 ENOG4108UKZ OsmC family HV181_01790 ENOG4105CJE phosphoribulokinase (EC 2.7.1.19) HV181_01800 ENOG4105DNZ Alpha Beta Hydrolase HV181_01805 ENOG4105C5H ABC transporter HV181_01820 ENOG4105VKU nucleicacid-binding protein HV181_01825 ENOG4108YZY peptidylprolyl cis-trans isomerase HV181_01835 ENOG4108V1T peptidylprolyl cis-trans isomerase HV181_01840 ENOG4105WWK YheO domain protein HV181_01880 ENOG4108NNZ chitinase HV181_01885 ENOG4105W53 bacterioferritin-associated ferredoxin HV181_01890 ENOG4108UQY Iron-storage protein HV181_01905 ENOG41063JA Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins (By similarity) HV181_01910 ENOG4105R04 type II secretion system protein K HV181_01925 ENOG41069X0 general secretion pathway protein h HV181_01930 ENOG4108VAU general secretion pathway protein G HV181_01935 ENOG4105D7Q type ii secretion system HV181_01940 ENOG4107QHF type ii secretion system protein e HV181_01945 ENOG4105GVR general secretion pathway protein D HV181_01950 ENOG4107KSE General secretion pathway protein C HV181_01955 ENOG410899B May play a regulatory role under conditions of derepressed gsp gene expression HV181_01960 ENOG4107ACA Calcium-binding protein required for initiation of chromosome replication HV181_01980 ENOG41080KG One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) HV181_02025 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) HV181_02070 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) HV181_02075 ENOG41067V7 50S ribosomal protein L36 HV181_02105 ENOG4105VTS DnaJ-like, subfamily C HV181_02110 ENOG4105W1Y Transcriptional regulator HV181_02115 ENOG4105VCN Rescues the ribosomes stalled at the 3' end of non-stop mRNAs. May induce hydrolysis of the ribosome-bound peptidyl-tRNA. This activity is crucial when the stalled ribosome can not be rescued by the SsrA(tmRNA)-SmpB quality control system HV181_02125 ENOG4105C1A potassium transporter peripheral membrane HV181_02145 ENOG4105C79 DNA protecting protein DprA HV181_02155 ENOG4108WI1 Dna topoisomerase HV181_02170 ENOG4105SG3 Protein of unknown function (DUF1488) HV181_02175 ENOG4108Z0R Transferase HV181_02215 ENOG4105CDA abc transporter atp-binding protein HV181_02220 ENOG4105DRP amino acid AbC transporter HV181_02225 ENOG4105EZ7 amino acid ABC transporter HV181_02235 ENOG4105XCM membrane LIPOPROTEIN HV181_02240 ENOG4105BZS acriflavin resistance protein HV181_02245 ENOG4105C1P efflux transporter, rnd family, mfp subunit HV181_02250 ENOG4108XG4 DNA-binding transcriptional regulator HV181_02255 ENOG41061ME transport protein HV181_02260 ENOG4105CEC DNA methylase N-4 N-6 HV181_02270 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) HV181_02280 ENOG4108IA2 Sodium pantothenate symporter HV181_02285 ENOG4105RG0 Membrane HV181_02290 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase HV181_02295 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein HV181_02300 ENOG4105D3Z quinone oxidoreductase, yhdh yhfp family HV181_02305 ENOG41062P1 Diguanylate cyclase phosphodiesterase HV181_02315 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) HV181_02320 ENOG4105VQ7 Rod shape-determining protein MreD HV181_02330 ENOG4105C03 ribonuclease HV181_02335 ENOG4105QD6 exported protein HV181_02340 ENOG4105D1U peptidase U62 modulator of DNA gyrase HV181_02345 ENOG4105CR8 Transcriptional regulator HV181_02350 ENOG4105ZQC membrane protein AaeX HV181_02365 ENOG4105UNR (Barnase) inhibitor HV181_02370 ENOG4105RID UPF0379 protein yhcN HV181_02385 ENOG4105C0H protease HV181_02390 ENOG4105C0H protease HV181_02395 ENOG4108W2Q Cytochrome d ubiquinol oxidase subunit III HV181_02400 ENOG4105D6Z AFG1 family ATPase HV181_02415 ENOG4107MKT Stringent starvation protein a HV181_02420 ENOG4105KB2 stringent starvation protein b HV181_02425 ENOG4105CEE C4-dicarboxylate transporter HV181_02430 ENOG4108QBF Transcriptional regulator HV181_02455 ENOG4108R66 Conserved Protein HV181_02460 ENOG4105DFS Conserved Protein HV181_02465 ENOG4105BZ8 glutamate synthase HV181_02470 ENOG4105CBC glutamate synthase HV181_02475 ENOG4105N5T Radical SAM Protein HV181_02480 ENOG4105BZU Histidine kinase HV181_02485 ENOG4108556 Isoprenoid biosynthesis protein with amidotransferase-like domain HV181_02495 ENOG4108NIH transferase activity, transferring phosphorus-containing groups HV181_02500 ENOG41080Z8 PHOSPHOCARRIER protein HV181_02510 ENOG4107RM2 PTS IIA-like nitrogen-regulatory protein PtsN HV181_02515 ENOG41080QH sigma 54 modulation protein ribosomal protein S30EA HV181_02520 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HV181_02525 ENOG4108IUZ ABC transporter HV181_02530 ENOG4105WI0 lipopolysaccharide transport periplasmic protein lptA HV181_02535 ENOG4108P1K Required for the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane (By similarity) HV181_02545 ENOG4105C2X Arabinose 5-phosphate isomerase HV181_02550 ENOG4105FEU K -dependent Na -Ca exchanger HV181_02555 ENOG4105DHJ ABC, transporter HV181_02560 ENOG4105CY3 ABC transporter, permease HV181_02565 ENOG4107PE3 Mammalian cell entry related domain protein HV181_02570 ENOG4105E3I toluene tolerance HV181_02575 ENOG4105UE2 Part of the ABC transporter complex MlaFEDB that actively prevents phospholipid accumulation at the cell surface. Probably maintains lipid asymmetry in the outer membrane by retrograde trafficking of phospholipids from the outer membrane to the inner membrane HV181_02580 ENOG4105VFK BolA family HV181_02590 ENOG4105HVQ Regulatory factor of maltose metabolism HV181_02595 ENOG4105EAH synthase HV181_02610 ENOG4105QYV Membrane HV181_02620 ENOG4106HRJ d-alanyl-d-alanine carboxypeptidase HV181_02625 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) HV181_02630 ENOG4105HBR Rna-binding protein HV181_02640 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) HV181_02645 ENOG4105EEI dihydropteroate synthase HV181_02655 ENOG4105NTZ Preprotein translocase subunit SecG HV181_02665 ENOG4105DIJ Phosphoethanolamine transferase HV181_02685 ENOG4105CHV Transcription elongation factor NusA HV181_02725 ENOG4105C1J atp-dependent rna helicase HV181_02730 ENOG4105CIC tryptophan-specific transport protein HV181_02735 ENOG4105DEN Luciferase family HV181_02755 ENOG4108YYD acetyltransferase HV181_02770 ENOG4107R7Y intracellular protease Pfpi family HV181_02775 ENOG4105K4T epimerase HV181_02780 ENOG4107S21 permease HV181_02785 ENOG4105W4M Transport-associated protein HV181_02805 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) HV181_02810 ENOG4105I74 Fimbrial protein HV181_02815 ENOG4105CW0 outer membrane usher protein HV181_02820 ENOG4108VCD Chaperone HV181_02825 ENOG4105Q10 Fimbrial-like protein HV181_02830 ENOG4106HBN Galactosamine-6-phosphate isomerase HV181_02835 ENOG4105F3R pts system mannose fructose sorbose family iid HV181_02840 ENOG4105ETZ PTS System HV181_02845 ENOG4108UZY PTS System HV181_02855 ENOG4105E70 isomerase HV181_02860 ENOG4105CE4 GlcNAc 6-P deacetylase HV181_02865 ENOG4108YTN IIa component HV181_02870 ENOG4105F3R pts system mannose fructose sorbose family iid HV181_02880 ENOG4108RG5 PTS system N-acetylgalactosamine-specific transporter subunit IIB HV181_02890 ENOG4105E98 transcriptional regulator DeoR family HV181_02895 ENOG4108R8Z these effects are overcome by concomitant expression of antitoxin SohA (PrlF). Massive overexpression is toxic. Unlike most other characterized TA systems degrades rRNA, and co-folding of the proteins is necessary in vitro for inhibition of the RNase activity. It is not known if it has any sequence-specificity. Acts as a transcription factor. The YhaV PrlF complex binds the prlF-yhaV operon, probably negatively regulating its expression HV181_02900 ENOG4105ZEG Suppressor protein HV181_02905 ENOG4105CTX dehydratase HV181_02910 ENOG4105DJB Major Facilitator Superfamily HV181_02920 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase HV181_02925 ENOG4105BZW Glycerate kinase HV181_02950 ENOG410811B TRANSCRIPTIONal HV181_02955 ENOG4105C7B Threonine dehydratase HV181_02965 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) HV181_02970 ENOG4105C6N Formate acetyltransferase HV181_02975 ENOG4105KME endoribonuclease L-psp HV181_02980 ENOG4105EJQ L-serine dehydratase HV181_02985 ENOG4105C44 Serine transporter HV181_02995 ENOG4106D80 Uncharacterized protein YhaL HV181_03000 ENOG4108CNN domain protein HV181_03005 ENOG4105CWB LysR family transcriptional Regulator HV181_03010 ENOG4105KAF membrAne HV181_03015 ENOG4105KAF membrAne HV181_03020 ENOG4105CHF Glutathione S-transferase HV181_03025 ENOG4108VBZ doxx family HV181_03030 ENOG4105YJD HV181_03035 ENOG41090KG Inner membrane protein YqjE HV181_03040 ENOG4105NE1 Conserved Protein HV181_03045 ENOG4105WAY exported protein HV181_03050 ENOG4105IYR Modulates the activity of the EnvZ OmpR two-component regulatory system, probably by directly modulating EnvZ enzymatic activity and increasing stability of phosphorylated OmpR (By similarity) HV181_03055 ENOG4106W5V Membrane HV181_03060 ENOG4107YCY Transcriptional regulator HV181_03095 ENOG4105CTX dehydratase HV181_03100 ENOG4105P66 Membrane HV181_03105 ENOG4107QV7 Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system) (By similarity) HV181_03110 ENOG4105DU1 integral membrane protein, terc HV181_03115 ENOG4105EE0 oxidoreductase HV181_03120 ENOG4108UB4 uncharacterized protein ygjQ HV181_03125 ENOG4108VKG metal-dependent hydrolase HV181_03140 ENOG4108Z3N Transcriptional regulator HV181_03145 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HV181_03150 ENOG4107WCA isomerase HV181_03155 ENOG4107W6W Conserved Protein HV181_03160 ENOG4105E5D amino acid HV181_03165 ENOG4105FK9 beta-D-galactosidase beta subunit HV181_03170 ENOG4105CNT hydrolase family 2 HV181_03175 ENOG4105CQ4 Transcriptional regulator HV181_03180 ENOG4108Y51 tRNA-binding protein HV181_03190 ENOG4107RHT methyl-accepting chemotaxis sensory transducer with Pas Pac sensor HV181_03195 ENOG4105NTW Transcriptional regulator HV181_03200 ENOG4105Q26 Siderophore-interacting protein HV181_03215 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HV181_03220 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) HV181_03230 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) HV181_03235 ENOG4107QPK )-transporter HV181_03240 ENOG4107GFK fumarate HV181_03245 ENOG4106DSS Tartrate dehydratase subunit alpha HV181_03250 ENOG4105EJC lysr family transcriptional regulator HV181_03260 ENOG4107ZVW dihydroneopterin aldolase HV181_03275 ENOG4106MWK domain protein HV181_03280 ENOG4105I7R Adenylate cyclase HV181_03305 ENOG4107S78 Band 7 protein HV181_03310 ENOG4105PV3 Inner membrane protein yqiJ HV181_03320 ENOG4108MY7 Fimbrial HV181_03325 ENOG4108TTM chaperone HV181_03335 ENOG4105H8W Fimbrial protein HV181_03340 ENOG4105W0Z cytoplasmic protein HV181_03360 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b HV181_03365 ENOG4106032 Glutathionylspermidine synthase HV181_03375 ENOG4105DFG type I secretion outer membrane protein HV181_03380 ENOG41087AY ADP-Ribose pyrophosphatase HV181_03385 ENOG4108SX3 cytoplasmic protein HV181_03390 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) HV181_03395 ENOG4105IPS esterase HV181_03400 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HV181_03420 ENOG4108RVA ribokinase HV181_03440 ENOG4105CT4 transporter HV181_03445 ENOG4105VRH Antibiotic biosynthesis monooxygenase HV181_03450 ENOG4105NF4 modulator of drug activity HV181_03455 ENOG4105DHQ Histidine kinase HV181_03460 ENOG4105XJC Two component transcriptional regulator (Winged helix family HV181_03465 ENOG4105H4F exported protein HV181_03470 ENOG4105F4I Transcriptional regulator HV181_03475 ENOG4105RT5 Toxic component of a toxin-antitoxin (TA) module. An mRNA interferase which has been reported to be translation- independent (PubMed 19690171, PubMed 19943910) and translation- dependent (PubMed 20041169). Cleavage has been reported to occur on either side of G in the sequence GCU (PubMed 19690171) but also after C in GC(A U) sequences (PubMed 19943910). There are only 14 genes in E.coli W3110 (and probably also MG1655) that do not have a GCU sequence and thus are resistant to the mRNA interferase activity. Overexpression causes cessation of cell growth and inhibits cell proliferation via inhibition of translation as well as increasing persister cell formation HV181_03480 ENOG4105WJ3 XRE family Transcriptional regulator HV181_03485 ENOG4108J59 Extracellular solute-binding protein, family 5 HV181_03490 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HV181_03495 ENOG4107S7E 1-acyl-sn-glycerol-3-phosphate acyltransferase HV181_03500 ENOG4107TZ2 Cell division protein that is required for growth during stress conditions. May be involved in protecting or stabilizing the divisomal assembly under conditions of stress (By similarity) HV181_03505 ENOG4105CCT upf0313 protein HV181_03515 ENOG4105ZKC Conserved Protein HV181_03520 ENOG4105CV8 reductase HV181_03525 ENOG4108I6A alcohol dehydrogenase HV181_03530 ENOG4105CF7 AraC family transcriptional regulator HV181_03535 ENOG4108K81 inner membrane protein YghB HV181_03540 ENOG4105C28 cystathionine HV181_03545 ENOG4105CWK Biopolymer transport protein, ExbB HV181_03550 ENOG4108ZZF transport protein (ExbD) HV181_03555 ENOG4105CYX Short-chain dehydrogenase reductase Sdr HV181_03565 ENOG4105CPC Aldo Keto reductase HV181_03575 ENOG410900S Protein of unknown function (DUF2623) HV181_03580 ENOG4105E3S small subunit HV181_03585 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein HV181_03590 ENOG4105CJ5 hydrogenase 2 b cytochrome subunit HV181_03595 ENOG4105DPX Hydrogenase, large subunit HV181_03600 ENOG4108USZ hydrogenase HV181_03605 ENOG4108WGS hydrogenase 2-specific chaperone HV181_03615 ENOG41082MF Hydrogenase assembly chaperone hypC hupF HV181_03620 ENOG4105CYM Glutathione S-transferase HV181_03625 ENOG4106032 Glutathionylspermidine synthase HV181_03630 ENOG4105CJ3 phosphate transporter HV181_03635 ENOG4108GH0 ATP-binding protein yghT HV181_03640 ENOG4108NDC ATP-binding protein yghS HV181_03645 ENOG4106FPV ATP-binding protein YghR HV181_03650 ENOG4108S55 polysaccharide biosynthesis protein HV181_03660 ENOG4108UUE Transcriptional regulator HV181_03665 ENOG4108M8S permease YjgP YjgQ family protein HV181_03675 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) HV181_03680 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) HV181_03690 ENOG4107RCI amp-dependent synthetase and ligase HV181_03700 ENOG4108KWP DNA-binding transcriptional regulator GlcC HV181_03705 ENOG4105CQB FAD linked oxidase domain protein HV181_03710 ENOG4105EU8 FAD linked oxidase domain protein HV181_03715 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) HV181_03720 ENOG4108ZJF Glcg protein HV181_03725 ENOG4107QP3 malate synthase g HV181_03730 ENOG4105DAA L-lactate HV181_03735 ENOG4105F88 accessory colonization factor AcfD HV181_03745 ENOG410765S (LipO)protein HV181_03760 ENOG4107QHF type ii secretion system protein e HV181_03765 ENOG4105D7Q type ii secretion system HV181_03770 ENOG4108VAU general secretion pathway protein G HV181_03780 ENOG4105X5Z General secretion pathway protein I HV181_03800 ENOG4105U1E general secretion pathway protein M HV181_03810 ENOG4108UQV Membrane HV181_03815 ENOG4105CXN decarboxylase HV181_03820 ENOG4105EAA nucleoside HV181_03835 ENOG4105CEN a g-specific adenine glycosylase HV181_03845 ENOG41090ED Protein with unknown function (DUF469) HV181_03850 ENOG4105K33 Periplasmic Protein HV181_03855 ENOG4105HDK L-asparaginase HV181_03860 ENOG4106MH3 alpha helix chain HV181_03865 ENOG4105CSA Coproporphyrinogen iii oxidase HV181_03870 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) HV181_03880 ENOG4108VIA integral membrane protein HV181_03885 ENOG4105DFA alanine racemase domain protein HV181_03890 ENOG4105CZX twitching motility protein HV181_03905 ENOG4105D7Z glutathione synthase HV181_03910 ENOG4105QF0 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) HV181_03915 ENOG4105RWS endonuclease I HV181_03925 ENOG4107QNK )-transporter HV181_03945 ENOG4105DP5 Catalyzes the biosynthesis of agmatine from arginine (By similarity) HV181_03960 ENOG4108K0D peptidase, M48 HV181_03965 ENOG4105CV1 Transketolase (EC 2.2.1.1) HV181_03970 ENOG4108X7Y Mannitol-specific cryptic phosphotransferase enzyme iia HV181_03975 ENOG4105CTS PTS system mannitol-specific HV181_03985 ENOG4108Q8A Fructose-1,6-bisphosphatase HV181_03990 ENOG4108R4K DNA-binding, transcriptional regulator HV181_03995 ENOG4107Z1W Fructose transport system kinase HV181_04000 ENOG4108JJB ABC transporter HV181_04005 ENOG4108JJB ABC transporter HV181_04035 ENOG4105D2N Aldolase HV181_04040 ENOG4105D64 Mechanosensitive ion channel HV181_04045 ENOG4108ZUB Lysine exporter protein (Lyse ygga) HV181_04050 ENOG4105MPN Membrane HV181_04055 ENOG4105DEQ transcriptional regulator HV181_04060 ENOG4105CYC Transferase HV181_04065 ENOG4108M7F enoyl-CoA hydratase isomerase HV181_04070 ENOG4105DJT lAO AO transport system ATPase HV181_04075 ENOG4105D5P Methylmalonyl-coA mutase HV181_04095 ENOG4108JQ1 Dehydrogenase HV181_04110 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase HV181_04130 ENOG4107RAQ aminopeptidase HV181_04135 ENOG4105D0A hydroxylase HV181_04140 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family HV181_04165 ENOG4105CYX Short-chain dehydrogenase reductase Sdr HV181_04170 ENOG4105CS2 ec 3.2.1.21 HV181_04180 ENOG4108UT2 hemolysin iii HV181_04190 ENOG4105Y75 tpr repeat protein HV181_04195 ENOG4108YDB Toxic component of a toxin-antitoxin (TA) module. Overexpression leads to growth arrest after 5 hours, with initial elongation of cells, followed by swelling. The toxic effects are abrogated by coexpression with antitoxin CptB. Interacts with cytoskeletal proteins FtsZ and MreB HV181_04200 ENOG41071R3 Low-potential electron donor to a number of redox enzymes (By similarity) HV181_04205 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HV181_04210 ENOG4105T95 Thiol disulfide interChange protein HV181_04215 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) HV181_04245 ENOG4105C2W permease HV181_04250 ENOG4105BZ8 glutamate synthase HV181_04255 ENOG4108R8B oxidoreductase Fe-S subunit HV181_04260 ENOG4105C7N Xanthine uracil vitamin C permease HV181_04265 ENOG4107QUY Guanine deaminase HV181_04270 ENOG4105C2W permease HV181_04275 ENOG4105C7W Xanthine dehydrogenase HV181_04280 ENOG410873Y FAD binding domain in molybdopterin dehydrogenase HV181_04285 ENOG4107UUR Chlorohydrolase aminohydrolase HV181_04290 ENOG4105BZ8 glutamate synthase HV181_04295 ENOG4105MFX 4-diphosphocytidyl-2c-methyl-d-erythritol synthase HV181_04300 ENOG4105MJ6 selenium-dependent hydroxylase accessory protein YqeC HV181_04305 ENOG4107P0T Selenium-dependent molybdenum hydroxylase system protein, YqeB family HV181_04310 ENOG4105C5B carbamate kinase HV181_04320 ENOG4107S4Y M20 DapE family protein YgeY HV181_04325 ENOG4107RCH Diaminopropionate ammonia-lyase HV181_04330 ENOG4105IW6 Carbamoyltransferase HV181_04335 ENOG4108JUB Transcriptional regulator HV181_04340 ENOG4108UTP (2Fe-2S)-binding domain protein HV181_04345 ENOG4108HR6 Dehydrogenase HV181_04350 ENOG4105C7W Xanthine dehydrogenase HV181_04355 ENOG4108K5P (LipO)protein HV181_04365 ENOG4108T88 HV181_04405 ENOG41075IY surface presentation of antigens protein SpaP HV181_04410 ENOG4105U07 type iii secretion HV181_04415 ENOG4108TN6 type iii secretion HV181_04425 ENOG4108M6W surface presentation of antigens protein SpaS HV181_04440 ENOG4108RC9 Type III secretion system protein HV181_04455 ENOG4108RBT type iii secretion HV181_04485 ENOG4108YAB Invasion protein HV181_04510 ENOG4105FV3 HV181_04515 ENOG4108TC1 Transcriptional regulator HV181_04520 ENOG4105ISV protein with bipartite regulator domain HV181_04525 ENOG4108MHD transport protein HV181_04530 ENOG4105CHU acetyl-coa acetyltransferase HV181_04540 ENOG4105CHR reductase HV181_04545 ENOG4107QNK )-transporter HV181_04555 ENOG4105RQF LysR family Transcriptional regulator HV181_04565 ENOG41060NJ transcriptional regulator HV181_04575 ENOG4107S74 Lysophospholipid transporter LplT HV181_04580 ENOG4105CPC Aldo Keto reductase HV181_04585 ENOG4105SUV lipoprotein YgdR HV181_04590 ENOG4105EE5 Membrane protein terC HV181_04605 ENOG4108HRM phosphoenolpyruvate--protein phosphotransferase HV181_04620 ENOG4105IPU prepilin peptidase dependent protein A HV181_04625 ENOG4105JCS prepilin peptidase dependent protein HV181_04630 ENOG4105SEN Protein of unknown function (DUF2509) HV181_04635 ENOG4105RVB Prepilin peptidase dependent protein c HV181_04640 ENOG4105DSY exodeoxyribonuclease V, gamma HV181_04645 ENOG4107QXK peptidase HV181_04650 ENOG4107QKA exodeoxyribonuclease V beta HV181_04655 ENOG4107QYX exodeoxyribonuclease v alpha HV181_04660 ENOG4108EKC n-acetylglutamate synthase HV181_04665 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase HV181_04685 ENOG4105CA3 membrane-bound lytic murein transglycosylase HV181_04690 ENOG4105CUZ uba thif-type nad fad binding protein HV181_04695 ENOG4105P9C Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity) HV181_04700 ENOG4105C9B Cysteine desulfurase HV181_04705 ENOG4105M5B (LipO)protein HV181_04710 ENOG4105ETT transcriptional Regulator, LysR family HV181_04715 ENOG4105M08 Membrane HV181_04725 ENOG4107EDW L-fucose operon activator HV181_04735 ENOG4105CMG Carbohydrate kinase HV181_04740 ENOG4105EHF Converts the aldose L-fucose into the corresponding ketose L-fuculose (By similarity) HV181_04745 ENOG4105EDR glucose galactose transporter HV181_04750 ENOG4107W7X Aldolase HV181_04755 ENOG4105C0A alcohol dehydrogenase HV181_04765 ENOG4105EJQ L-serine dehydratase HV181_04770 ENOG4105C44 Serine transporter HV181_04775 ENOG4105EWT decarboxylase family HV181_04790 ENOG4105WP7 tRNA pseudouridine synthase C HV181_04795 ENOG4105DR9 pseudouridine synthase HV181_04800 ENOG4105QDK Flavodoxin HV181_04805 ENOG4105DJB Major Facilitator Superfamily HV181_04810 ENOG4105EQX glucarate dehydratase HV181_04815 ENOG4105EQX glucarate dehydratase HV181_04820 ENOG4105BZU Histidine kinase HV181_04825 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) HV181_04830 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) HV181_04835 ENOG4106A2Z transcriptional regulator antitoxin, MazE HV181_04840 ENOG4105MZG transcriptional modulator of maze toxin, mazf HV181_04845 ENOG4105DXN mazG family HV181_04860 ENOG4105HA9 of methanol dehydrogenase type HV181_04870 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) HV181_04875 ENOG4108CWB sugar kinase ygcE HV181_04880 ENOG4108ITV Inner membrane protein yqcE HV181_04885 ENOG4105CHR reductase HV181_04890 ENOG4107R3A FAD linked oxidase domain protein HV181_04895 ENOG4105C54 Major Facilitator superfamily HV181_04900 ENOG4106IKH Electron transfer flavoprotein HV181_04905 ENOG4105YBM electron transfer flavoprotein subunit ygcQ HV181_04910 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator HV181_04915 ENOG4105WQV ferredoxin-like protein HV181_04920 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase HV181_04925 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase HV181_04945 ENOG4107635 Hok Gef family protein HV181_04950 ENOG4105DTT CRISPR-associated helicase, cas3 HV181_04955 ENOG4105CYR Crispr-associated protein, cse1 family HV181_04965 ENOG41060M0 Crispr-associated protein, cse4 family HV181_04970 ENOG4108VWQ crispr-associated protein HV181_04980 ENOG4105TZK CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. May be involved in the integration of spacer DNA into the CRISPR cassette (By similarity) HV181_04985 ENOG4105PWE CRISPR-associated protein cas2 HV181_04990 ENOG4108MXK alkaline phosphatase isozyme conversion HV181_04995 ENOG4105C11 sulfate adenylyltransferase), subunit 2 HV181_05000 ENOG4105C3T may be the GTPase, regulating ATP sulfurylase activity (By similarity) HV181_05010 ENOG4105N0Z inner membrane protein ygbE HV181_05045 ENOG4108K5P (LipO)protein HV181_05055 ENOG4105C6Z Gluconate HV181_05060 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) HV181_05065 ENOG4105FB2 class II Aldolase HV181_05070 ENOG4105G63 Type III effector Hrp-dependent HV181_05075 ENOG4105ZXK Dehydrogenase HV181_05080 ENOG4105MVE transcriptional regulator HV181_05085 ENOG4105MEW serine threonine protein phosphatase HV181_05100 ENOG4105VXR cytoplasmic protein HV181_05105 ENOG4108JUA Transcriptional regulator HV181_05110 ENOG4105C45 hydrogenase expression formation protein (HypE) HV181_05115 ENOG4105CQS hydrogenase expression formation protein HypD HV181_05120 ENOG41083WG hydrogenase assembly chaperone HV181_05125 ENOG4107RSS Hydrogenase accessory protein HypB HV181_05130 ENOG410816D Probably plays a role in a hydrogenase nickel cofactor insertion step (By similarity) HV181_05135 ENOG4108VRC Formate hydrogenlyase regulatory protein hycA HV181_05140 ENOG4108MFN small subunit of hydrogenase-3, iron-sulfur protein (part of formate hydrogenlyase (FHL) complex) HV181_05145 ENOG4107R30 NADH dehydrogenase HV181_05150 ENOG4107TDF Formate hydrogenlyase subunit 4 HV181_05155 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HV181_05160 ENOG4108RG7 formate hydrogenlyase complex iron-sulfur subunit HV181_05165 ENOG4105C47 NADH ubiquinone oxidoreductase 20 kda subunit HV181_05170 ENOG4105I6X formate hydrogenlyase maturation HV181_05175 ENOG4108MG9 hydrogenase 3 maturation protease HV181_05185 ENOG4105RVE Uncharacterized protein conserved in bacteria (DUF2136) HV181_05190 ENOG4108Z3N Transcriptional regulator HV181_05195 ENOG4105CS2 ec 3.2.1.21 HV181_05200 ENOG4105C5Y PTS System HV181_05205 ENOG4105DDV Transcriptional regulator (LacI family HV181_05210 ENOG4108RC0 Electron transport protein HV181_05215 ENOG4105C8H hydrogenase maturation protein Hypf HV181_05235 ENOG4105C2X Arabinose 5-phosphate isomerase HV181_05240 ENOG410804X Transcriptional regulator HV181_05245 ENOG4105J92 DNA-binding transcriptional activator GutM HV181_05250 ENOG4107QMF Sorbitol-6-phosphate dehydrogenase HV181_05255 ENOG4105VI0 Pts system, glucitol sorbitol-specific HV181_05260 ENOG4105DZY Pts system, glucitol sorbitol-specific HV181_05265 ENOG410787A Pts system, glucitol sorbitol-specific HV181_05270 ENOG4105CVE Lytic murein transglycosylase HV181_05275 ENOG4107TH8 cina domain protein HV181_05295 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) HV181_05325 ENOG4107VXZ Hydrolase HV181_05330 ENOG4105W39 Membrane HV181_05345 ENOG4105C0R drug resistance transporter emrb qaca subfamily HV181_05350 ENOG4105CW7 secretion protein, HlyD family HV181_05355 ENOG4105NTK Transcriptional repressor Mpra HV181_05360 ENOG4105ZED uncharacterized protein ygaH HV181_05365 ENOG4108UMN azlc family HV181_05375 ENOG4105GIJ Glycine betaine HV181_05380 ENOG4108HQS Glycine betaine HV181_05385 ENOG4108IJ7 Glycine betaine HV181_05390 ENOG4107R25 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HV181_05395 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HV181_05405 ENOG4105WAZ (Glutaredoxin-like protein) NrdH HV181_05410 ENOG4108ZQZ Bacterial protein of unknown function (DUF883) HV181_05415 ENOG4108WMJ Protein of unknown function (DUF2002) HV181_05420 ENOG4108RNS Exports L-alanine (By similarity) HV181_05425 ENOG4108X73 DNA- binding protein HV181_05430 ENOG4108V62 Rhodanese domain protein HV181_05435 ENOG41080HT Transcriptional regulator, arsr family HV181_05440 ENOG4105VPI YqaE family transport protein HV181_05445 ENOG4109066 lysm domain bon superfamily protein HV181_05450 ENOG4108PVQ transcriptional regulator HV181_05455 ENOG4105C85 amino acid HV181_05460 ENOG4108JPW Aminotransferase HV181_05465 ENOG4105C26 Dehydrogenase HV181_05470 ENOG4105D5U fad dependent oxidoreductase HV181_05475 ENOG4105EK3 May be involved in the control of utilization of gamma- aminobutyric acid (By similarity) HV181_05535 ENOG4105MAW Antitoxin component of a toxin-antitoxin (TA) module. Labile antitoxin that counteracts the effect of the CbtA (YeeV) toxin. It does not bind to the cognate toxin but instead binds to MreB and FtsZ (the toxin targets), enhancing their polymerization by forming higher-order bundles HV181_05540 ENOG4105ZS6 Protein of unknown function (DUF987) HV181_05545 ENOG4108XS9 dna repair protein HV181_05550 ENOG4106549 Antirestriction protein HV181_05555 ENOG4106ZN7 UPF0401 protein YkfF HV181_05560 ENOG4106J9S Prophage HV181_05575 ENOG4108KZE transcriptional regulator HV181_05580 ENOG4106H6R UPF0380 protein HV181_05615 ENOG4108MXD gtp-binding protein HV181_05635 ENOG4105JXR Protein of unknown function (DUF3296) HV181_05650 ENOG410679B prophage CP4-57 regulatory protein alpA HV181_05665 ENOG4105DFP Integrase HV181_05680 ENOG4108Z1B Cyclase dehydrase HV181_05690 ENOG4105YRI Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) HV181_05695 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) HV181_05710 ENOG4108JU6 CBS domain protein HV181_05715 ENOG4106KVJ cytochrome C assembly protein HV181_05720 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY HV181_05745 ENOG41090EK ompa motb domain protein HV181_05750 ENOG4108KHX Diguanylate cyclase HV181_05755 ENOG4108WS1 HV181_05760 ENOG4105QP9 Protein of unknown function (DUF2799) HV181_05765 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) HV181_05770 ENOG4105EHE chorismate mutase- prephenate dehydrogenase HV181_05775 ENOG4105CQC Prephenate dehydratase HV181_05785 ENOG4108WPH sigma 54 modulation protein ribosomal protein S30EA HV181_05790 ENOG4106SNF Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane HV181_05795 ENOG4105C34 Pseudouridine synthase HV181_05800 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase HV181_05805 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit HV181_05830 ENOG4105CSH Transporter HV181_05835 ENOG4105T42 (LipO)protein HV181_05840 ENOG4105JIM Phosphatidylserine synthase HV181_05845 ENOG4105CD5 CoA-binding domain protein HV181_05850 ENOG4106IUH DTW domain containing protein HV181_05855 ENOG4105K63 Thioredoxin HV181_05860 ENOG4105EIB trna rrna methyltransferase HV181_05880 ENOG41090KR LysR family transcriptional Regulator HV181_05885 ENOG4105C1J atp-dependent rna helicase HV181_05895 ENOG4108IYU L-aspartate oxidase HV181_05905 ENOG4105EMN RNA polymerase sigma factor HV181_05910 ENOG41069PW sigma-e factor negative regulatory protein HV181_05915 ENOG4105VQK sigma E regulatory protein, MucB RseB HV181_05920 ENOG4105WMJ Positive regulator of sigma E, RseC MucC HV181_05930 ENOG4105C3F Signal peptidase i HV181_05950 ENOG4105CSZ Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity) HV181_05965 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding HV181_05970 ENOG4106G6Q Transcriptional regulator HV181_05975 ENOG4105HYY HAD superfamily (Subfamily IF) hydrolase, YfhB HV181_05980 ENOG4108Z6B deaminase HV181_05995 ENOG4107WP9 Histidine kinase HV181_06000 ENOG4108SKK alpha helix protein HV181_06005 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family HV181_06015 ENOG4108EGH Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) HV181_06025 ENOG4108NZE NAGC-like transcriptional regulator HV181_06030 ENOG4107HQ7 repeat protein HV181_06035 ENOG4105FCA ABC transporter periplasmic-binding protein YphF HV181_06040 ENOG4108F37 ATP-binding component of a transport system HV181_06045 ENOG4105CNN ABC, transporter HV181_06050 ENOG4105CPQ Dehydrogenase HV181_06055 ENOG4108ZKT aldose 1-epimerase HV181_06060 ENOG4108SB3 DoxX Family HV181_06085 ENOG4105FUY alpha subunit HV181_06090 ENOG4108W5M transcriptional regulator HV181_06095 ENOG4105D8G Major Facilitator superfamily HV181_06100 ENOG4108MN2 Stationary phase inducible protein CsiE HV181_06105 ENOG4107XM9 (LipO)protein HV181_06110 ENOG4105ECY inositol monophosphatase HV181_06130 ENOG4107XTC May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins HV181_06150 ENOG4108ZIT Ferredoxin, 2FE-2S HV181_06155 ENOG4105WVQ Fe-S assembly protein IscX HV181_06165 ENOG4105YYA enhanced serine sensitivity protein SseB HV181_06170 ENOG4105KHC sulfurtransferase HV181_06175 ENOG4105DN3 alpha-2-macroglobulin domain protein HV181_06180 ENOG4108JQB penicillin-binding protein 1C HV181_06210 ENOG4105N21 Membrane HV181_06225 ENOG4105VPD cellular component movement HV181_06235 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) HV181_06245 ENOG41066DY Membrane HV181_06250 ENOG4108ZMA Outer membrane lipoprotein HV181_06255 ENOG41062G3 Protein of unknown function (DUF2633) HV181_06265 ENOG4105BZU Histidine kinase HV181_06270 ENOG4105C9X ppx gppa phosphatase HV181_06275 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) HV181_06280 ENOG4108V3E phosphoribosylglycinamide formyltransferase HV181_06295 ENOG4105C2W permease HV181_06300 ENOG4108KZ1 Mediates the interaction of DNA replication inititator protein DnaA with DNA polymerase subunit beta sliding clamp (dnaN). Stimulates hydrolysis of ATP-DnaA to ADP-DnaA, rendering DnaA inactive for reinititation, a process called regulatory inhibition of DnaA or RIDA (By similarity) HV181_06305 ENOG4105K89 arsenate reductase HV181_06310 ENOG4105ERG peptidase m48, ste24p HV181_06315 ENOG4105C02 permease HV181_06320 ENOG4105TMB Formate nitrite transporter HV181_06325 ENOG4108JUA Transcriptional regulator HV181_06330 ENOG4105I6X formate hydrogenlyase maturation HV181_06345 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HV181_06350 ENOG4108JPZ Monovalent cation H antiporter subunit D HV181_06355 ENOG4107WQX hydrogenase 4 membrane subunit HV181_06365 ENOG4105D65 subunit l HV181_06370 ENOG4107TDF Formate hydrogenlyase subunit 4 HV181_06380 ENOG4108MFN small subunit of hydrogenase-3, iron-sulfur protein (part of formate hydrogenlyase (FHL) complex) HV181_06385 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen HV181_06390 ENOG4105RH4 Glycine cleavage system transcriptional repressor HV181_06400 ENOG4107EG0 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) HV181_06415 ENOG4105M0J Toxic component of a toxin-antitoxin (TA) module. A HV181_06420 ENOG4105CGZ zinc metallopeptidase HV181_06430 ENOG4106KED esterase YpfH HV181_06445 ENOG4105KUZ arsenate reductase HV181_06450 ENOG4107TII Recombinase HV181_06480 ENOG4105W5Q DNA repair protein (RadC HV181_06515 ENOG4105CI6 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving HV181_06525 ENOG4105BZS acriflavin resistance protein HV181_06530 ENOG4105BZU Histidine kinase HV181_06535 ENOG4105BZ8 glutamate synthase HV181_06545 ENOG4108PVD exported protein HV181_06550 ENOG4105CV1 Transketolase (EC 2.2.1.1) HV181_06555 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) HV181_06560 ENOG4105C6K Malic enzyme HV181_06565 ENOG4108VJN May be involved in the formation of a specific microcompartment in the cell in which the metabolism of potentially toxic by-products takes place HV181_06570 ENOG4106S4J ethanolamine utilization protein EutP HV181_06575 ENOG4105NDK ethanolamine utilization protein HV181_06580 ENOG4108PFF ethanolamine utilization cobalamin adenosyltransferase HV181_06585 ENOG4107WUY phosphate acetyltransferase HV181_06590 ENOG4105KNY Microcompartments protein HV181_06595 ENOG4105WVM ethanolamine utilization protein EutN carboxysome structural protein Ccml HV181_06600 ENOG4108EKI Dehydrogenase HV181_06605 ENOG4107RWI ethanolamine utilization protein eutJ HV181_06610 ENOG4105C0A alcohol dehydrogenase HV181_06615 ENOG4105ENY Ethanolamine utilization protein eutH HV181_06620 ENOG4105DYY Reactivating factor for ethanolamine ammonia lyase HV181_06625 ENOG4105CPD ethanolamine ammonia-lyase HV181_06635 ENOG4106D67 ethanolamine utilization protein HV181_06640 ENOG4108X49 Ethanolamine utilization protein EutK HV181_06645 ENOG4108K3Z AraC family transcriptional regulator HV181_06655 ENOG4108KNB n-acetylmuramoyl-l-alanine amidase HV181_06665 ENOG4105QZU Inner membrane protein YfeZ HV181_06670 ENOG4105E7K (LipO)protein HV181_06675 ENOG4105EZR dyp-type peroxidase family protein HV181_06680 ENOG4107S1E Beta-lactamase HV181_06685 ENOG4105C5Y PTS System HV181_06700 ENOG4105I7Z Short-chain dehydrogenase reductase Sdr HV181_06705 ENOG4108J2H Sulfate ABC transporter periplasmic sulfate-binding protein HV181_06710 ENOG4108I5D sulfate abc transporter HV181_06715 ENOG4105ECW sulfate abc transporter HV181_06720 ENOG4108IJ6 ABC transporter HV181_06725 ENOG4105C6T cysteine synthase HV181_06730 ENOG4105M0Y HV181_06740 ENOG4105C5Y PTS System HV181_06745 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) HV181_06755 ENOG4105C6T cysteine synthase HV181_06775 ENOG4105VRT cytoplasmic protein HV181_06780 ENOG4105DHU Bile acid HV181_06785 ENOG4108M0I Transcriptional regulator HV181_06820 ENOG4105GXM Putative transcription regulator (DUF1323) HV181_06825 ENOG4105HZG regulatoR HV181_06840 ENOG4108KMM Diguanylate cyclase HV181_06845 ENOG4105D9N nucleoside HV181_06855 ENOG4109076 Conserved Protein HV181_06870 ENOG4105R6B The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane (By similarity) HV181_06875 ENOG410863U PTS System HV181_06880 ENOG4105DC7 peptidase M24 HV181_06885 ENOG4105CN9 Peptidase m42 family protein HV181_06890 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) HV181_06895 ENOG4108CIP transcriptional regulator HV181_06900 ENOG4105DY9 regulatoR HV181_06905 ENOG4108HRK Histidine kinase HV181_06910 ENOG4105CHM Aminotransferase HV181_06920 ENOG4105D1S lipid A biosynthesis HV181_06925 ENOG4105W9M Membrane HV181_06935 ENOG4108V08 YfdX protein HV181_06945 ENOG4105CFN oxalyl-CoA decarboxylase HV181_06950 ENOG4108N2Y auxin Efflux HV181_06955 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F HV181_06965 ENOG4108WQH regulatoR HV181_06970 ENOG4105CW7 secretion protein, HlyD family HV181_06975 ENOG4105C0R drug resistance transporter emrb qaca subfamily HV181_06990 ENOG4106NDP Transcriptional regulator HV181_06995 ENOG4108HKT sucrose-6-phosphate hydrolase HV181_07000 ENOG4105D7K pfkb domain protein HV181_07005 ENOG4105U0F oligosaccharide H symporter, major facilitator superfamily (MFS) HV181_07110 ENOG4108UUM single-stranded DNA-binding protein HV181_07115 ENOG4105VIZ double-strand break repair protein HV181_07190 ENOG4105NY2 NinB protein HV181_07220 ENOG4105RWQ Protein of unknown function (DUF1364) HV181_07250 ENOG4105SZK Rz endopeptidase from lambdoid prophage DLP12 HV181_07280 ENOG4108N0N Phage Terminase Large Subunit HV181_07395 ENOG4105DFP Integrase HV181_07405 ENOG4105S64 Formate nitrite transporter HV181_07410 ENOG410903C (LipO)protein HV181_07420 ENOG4105CKF membrane protein involved in aromatic hydrocarbon degradation HV181_07425 ENOG4105KZW UPF0381 protein HV181_07440 ENOG4108BY2 phosphohistidine phosphatase HV181_07450 ENOG4106PG1 outer membrane usher protein HV181_07455 ENOG4108FZ9 Chaperone HV181_07460 ENOG4105NEV Fimbrial HV181_07465 ENOG4105UGQ Fimbrial HV181_07470 ENOG4105US4 fimbrial-like protein yfcP HV181_07500 ENOG4105EJ9 Membrane HV181_07505 ENOG4108BPE -transporting atpase HV181_07510 ENOG4105MH2 YfcL protein HV181_07515 ENOG4105CWG Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity) HV181_07520 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) HV181_07525 ENOG4105F9N Major Facilitator Superfamily HV181_07530 ENOG4106WZ1 flagella biosynthesis regulator HV181_07540 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) HV181_07550 ENOG4105DQR SNARE associated Golgi HV181_07560 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase HV181_07565 ENOG4108S3P Sporulation domain protein HV181_07570 ENOG4105E96 Colicin v production protein HV181_07575 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase HV181_07580 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase HV181_07585 ENOG4105E89 ABC transporter HV181_07590 ENOG4105E89 ABC transporter HV181_07595 ENOG4105DSP amino acid AbC transporter HV181_07600 ENOG4106YG3 ABC transporter HV181_07605 ENOG4108JEH abc transporter atp-binding protein HV181_07610 ENOG4105DNE Transposase HV181_07615 ENOG4105ECP epimerase HV181_07620 ENOG4105KKP D-erythro-7,8-dihydroneopterin triphosphate 2'-epimerase HV181_07625 ENOG4105CYM Glutathione S-transferase HV181_07630 ENOG4108SHQ Glutathione S-transferase HV181_07635 ENOG4108RE9 Phosphodiesterase HV181_07640 ENOG4105PTV Nudix Hydrolase HV181_07645 ENOG4105CSX c4-dicarboxylate anaerobic carrier HV181_07650 ENOG4105C6K Malic enzyme HV181_07655 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) HV181_07665 ENOG4105XWI UPF0304 protein HV181_07670 ENOG4105EVE HAD-superfamily hydrolase subfamily IA variant 3 HV181_07675 ENOG4107QWE )-transporter HV181_07685 ENOG4105CHM Aminotransferase HV181_07690 ENOG4107NQ8 LysR family Transcriptional regulator HV181_07710 ENOG4105GKE subunit e HV181_07715 ENOG4107QIZ NADH dehydrogenase HV181_07720 ENOG4108IEH NADH dehydrogenase subunit g HV181_07735 ENOG4107UFS subunit j HV181_07745 ENOG4105D65 subunit l HV181_07750 ENOG4105C8S subunit m HV181_07760 ENOG4105GDX Domain of unknown function (DUF1877) HV181_07765 ENOG4107VAM peptidase, m28 HV181_07770 ENOG4105CP2 von willebrand factor, type a HV181_07795 ENOG4107YB6 acetyltransferase, (GNAT) family HV181_07800 ENOG4105TNS Conserved Protein HV181_07805 ENOG4105E4F Isochorismate synthase HV181_07820 ENOG4108IPT Naphthoate synthase HV181_07830 ENOG4105CEY Amp-dependent synthetase and ligase HV181_07835 ENOG4106GZG polymyxin resistance protein B HV181_07850 ENOG4105SA9 Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity) HV181_07900 ENOG4105DNE Transposase HV181_07905 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) HV181_07915 ENOG4107R5Y anaerobic glycerol-3-phosphate dehydrogenase, subunit A HV181_07920 ENOG4105CXY transporter HV181_07925 ENOG4106MZZ glycerophosphoryl diester phosphodiesterase HV181_07945 ENOG4105FQR PH-inducible protein involved in stress response HV181_07950 ENOG4105XPH Ferredoxin HV181_07955 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HV181_07960 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HV181_07965 ENOG4107GHC outer membrane autotransporter HV181_07970 ENOG4108HWB Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) HV181_07975 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HV181_07980 ENOG4107FKF Uncharacterized protein conserved in bacteria (DUF2138) HV181_07990 ENOG4107S52 alpha-2-macroglobulin domain protein HV181_07995 ENOG41081SK signal peptide protein HV181_08000 ENOG4105EDV vault protein HV181_08005 ENOG4105CHU acetyl-coa acetyltransferase HV181_08010 ENOG4105CRW Short chain fatty acid transporter HV181_08015 ENOG4107QNJ CoA-transferase subunit B HV181_08020 ENOG4107QP7 CoA-transferase subunit A HV181_08025 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family HV181_08030 ENOG4105BZU Histidine kinase HV181_08035 ENOG4105BZU Histidine kinase HV181_08040 ENOG41068CG regulatoR HV181_08045 ENOG4105E3G Phosphotransfer intermediate protein in two-component regulatory system with RcsBC HV181_08050 ENOG4105FCK Membrane HV181_08055 ENOG4105CJ2 (LipO)protein HV181_08060 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) HV181_08065 ENOG4105CF1 Alkylated DNA repair protein HV181_08070 ENOG4105IBP Cyclic peptide transporter HV181_08075 ENOG4105DWT malate dehydrogenase (quinone) HV181_08085 ENOG4108ZNS ferredoxin-type protein NapF HV181_08090 ENOG41061Q0 Assembly protein for periplasmic nitrate reductase HV181_08100 ENOG4108BGM Quinol dehydrogenase periplasmic component HV181_08105 ENOG4105GXZ Ferredoxin-type protein NapH HV181_08110 ENOG4108ZMS Electron transfer subunit of the periplasmic nitrate reductase complex NapAB (By similarity) HV181_08115 ENOG4105CUW cytochrome C-TYPE protein HV181_08120 ENOG4107EV4 once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system (By similarity) HV181_08125 ENOG4105CA5 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes (By similarity) HV181_08130 ENOG41060IM Heme exporter protein HV181_08135 ENOG4105X3C heme exporter protein HV181_08145 ENOG4105DA4 cytochrome c-type biogenesis protein HV181_08150 ENOG4107QX9 Thiol disulfide interChange protein HV181_08155 ENOG4105KWW Biogenesis protein HV181_08160 ENOG4105WH1 Two component transcriptional regulator luxr family HV181_08165 ENOG4108MGN ATP-binding component of a transport system HV181_08170 ENOG4105VNT transposase (IS4 family) protein HV181_08180 ENOG4105E68 Sulfatase HV181_08200 ENOG4105CFI type iii restriction protein res subunit HV181_08205 ENOG4105I08 Pseudouridine synthase HV181_08210 ENOG4105C2C drug resistance transporter, Bcr CflA HV181_08215 ENOG4105HG6 HV181_08220 ENOG4108JQ5 ABC transporter HV181_08225 ENOG4108IYQ Binding-protein-dependent transport systems inner membrane component HV181_08230 ENOG4108I5X binding-protein-dependent transport systems inner membrane Component HV181_08235 ENOG4105E43 Extracellular solute-binding protein, family 5 HV181_08240 ENOG4105CXC rtn protein HV181_08245 ENOG4107TT5 NLP P60 protein HV181_08250 ENOG41076MN Phosphoesterase, PA-phosphatase related HV181_08255 ENOG4105CKI cobalamin synthesis protein HV181_08260 ENOG4105DEI Mannitol dehydrogenase HV181_08270 ENOG4105KRS Proteinase inhibitor HV181_08275 ENOG4105S8Q sugar efflux transporter HV181_08280 ENOG4105DTZ bifunctional PTS system fructose-specific transporter subunit IIA HPr protein HV181_08285 ENOG4105DE4 1-phosphofructokinase HV181_08290 ENOG4105DM4 PTS System HV181_08295 ENOG4105DD7 kinase (PfkB family HV181_08300 ENOG4105D53 Catalyzes the hydrolysis of pseudouridine 5'-phosphate (PsiMP) to ribose 5-phosphate and uracil (By similarity) HV181_08305 ENOG4105D9N nucleoside HV181_08310 ENOG4108Y4K DNA-binding transcriptional activator HV181_08320 ENOG4105D9N nucleoside HV181_08325 ENOG4105DD7 kinase (PfkB family HV181_08335 ENOG4105HMI Membrane HV181_08340 ENOG4105DUM transcriptional regulator, lysR family HV181_08345 ENOG4108IQI permease HV181_08350 ENOG4105D05 Receptor HV181_08355 ENOG4105C4W S-formylglutathione hydrolase HV181_08365 ENOG4105DHF Membrane HV181_08370 ENOG41060NJ transcriptional regulator HV181_08375 ENOG4105EMA Periplasmic binding protein LacI transcriptional regulator HV181_08380 ENOG4105C2J ABC transporter HV181_08385 ENOG4108HWV )-transporter HV181_08390 ENOG4107SJI Dehydrogenase HV181_08395 ENOG4105BZ8 glutamate synthase HV181_08400 ENOG4105Y9N Membrane HV181_08405 ENOG4107GZ4 SanA protein HV181_08415 ENOG41067MG lrgb family HV181_08425 ENOG4105FBT Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity) HV181_08435 ENOG4105ETP RND efflux system, outer membrane lipoprotein HV181_08440 ENOG4105H9W Short-chain dehydrogenase reductase Sdr HV181_08445 ENOG4105KHU inner membrane protein YohD HV181_08450 ENOG41069YE inner membrane protein yohC HV181_08455 ENOG41061WM D-Alanyl-D-Alanine HV181_08460 ENOG4105CXG d-lactate dehydrogenase HV181_08465 ENOG4107QK4 glycoside hydrolase, family 3 domain protein HV181_08470 ENOG4107SI7 Substrate-binding region of abc-type glycine betaine transport system HV181_08475 ENOG4107T5X Binding-protein-dependent transport systems, inner membrane component HV181_08480 ENOG4108IJ8 ABC transporter HV181_08485 ENOG4105WJV Binding-protein-dependent transport systems, inner membrane component HV181_08495 ENOG4108XDN Transcriptional regulator HV181_08500 ENOG4108HRK Histidine kinase HV181_08505 ENOG4108NEV two component transcriptional regulator, LytTR family HV181_08510 ENOG4108W15 Protein of unknown function (DUF1456) HV181_08515 ENOG4108YCW (LipO)protein HV181_08520 ENOG410903U zinc ion binding HV181_08525 ENOG4105DEG Vwa containing coxe family protein HV181_08530 ENOG4105RD5 HV181_08535 ENOG4105KKX ATPase associated with various cellular activities aaa_5 HV181_08550 ENOG4108KDT Molybdate metabolism regulator HV181_08560 ENOG4105D1F ATP-binding protein HV181_08565 ENOG41067AK Protein of unknown function (DUF2574) HV181_08570 ENOG41063W2 Fimbrial protein HV181_08575 ENOG4108MQF Chaperone HV181_08580 ENOG4105CW0 outer membrane usher protein HV181_08585 ENOG410662B Type-1 fimbrial protein HV181_08590 ENOG4108Z1S Influences nickel and cobalt homeostasis. May act by modulating RcnA-mediated export of these ions to avoid excess efflux. Not involved in nickel import and does not bind nickel or cobalt ions directly HV181_08610 ENOG4105DWF phosphomethylpyrimidine kinase HV181_08620 ENOG4105FDP GntR family transcriptional regulator HV181_08625 ENOG4108TFM Kinase, PfkB family HV181_08630 ENOG4108KD5 ADP-ribosylation crystallin J1 HV181_08635 ENOG4105EAA nucleoside HV181_08640 ENOG4105EIE fructose-bisphosphate aldolase HV181_08655 ENOG41082GB PTS system galactitol-specific transporter subunit IIA HV181_08660 ENOG41090UW PTS System HV181_08665 ENOG4105DT3 PTS system, galactitol-specific IIc component HV181_08670 ENOG4107WTH Galactitol-1-phosphate dehydrogenase HV181_08685 ENOG41076Z6 Uncharacterized protein yegR HV181_08690 ENOG4105CFP Peptidase U32 HV181_08695 ENOG4105KWI UPF0339 protein HV181_08700 ENOG4105E3W Two component transcriptional regulator (Winged helix family HV181_08705 ENOG4105EB3 Histidine kinase HV181_08715 ENOG4105BZS acriflavin resistance protein HV181_08720 ENOG4105BZS acriflavin resistance protein HV181_08740 ENOG4108M24 von Willebrand factor, type A HV181_08745 ENOG4105UM3 Inherit from NOG: serine threonine phosphoprotein phosphatase HV181_08750 ENOG4105ZD5 Uncharacterized protein conserved in bacteria (DUF2314) HV181_08755 ENOG4106E1W protein with protein kinase and helix-hairpin-helix DNA-binding HV181_08760 ENOG4105R8A Heat shock protein HV181_08765 ENOG4105D03 DNA-3-methyladenine glycosylase II HV181_08770 ENOG4105BZU Histidine kinase HV181_08775 ENOG4105DBI uridine monophosphokinase HV181_08785 ENOG4108GAE asmA family HV181_08790 ENOG4105EE5 Membrane protein terC HV181_08795 ENOG4105DAY polysaccharide export protein HV181_08800 ENOG4105KJF protein tyrosine phosphatase HV181_08805 ENOG4105D75 Capsular exopolysaccharide family HV181_08810 ENOG41090RK glycosyl transferase HV181_08815 ENOG41068PY Colanic acid biosynthesis acetyltransferase wcaB HV181_08820 ENOG4107RXY Glycosyl transferase HV181_08825 ENOG4108NYJ Colanic acid HV181_08830 ENOG4105ECJ Glycosyl Transferase HV181_08835 ENOG4108Z90 colanic acid biosynthesis acetyltransferase wcaF HV181_08840 ENOG4105C0K Gdp-mannose 4,6-dehydratase HV181_08845 ENOG4105C30 Nad-dependent epimerase dehydratase HV181_08850 ENOG4105FGF GDP-mannose mannosyl hydrolase HV181_08855 ENOG4106CD9 glycosyl transferase group 1 HV181_08860 ENOG4105CJT Mannose-1-phosphate guanylyltransferase HV181_08865 ENOG4107QKV phosphomannomutase HV181_08870 ENOG4105D3Q Sugar transferase HV181_08875 ENOG4105PSV Polysaccharide Biosynthesis Protein HV181_08880 ENOG4105C74 pyruvyl transferase HV181_08885 ENOG4107T8Q Glycosyl transferase (Group 1 HV181_08890 ENOG4105G1A colanic acid biosynthesis protein HV181_08895 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase HV181_08900 ENOG4105CPK Glycosyl transferase (Group 1 HV181_08925 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) HV181_08935 ENOG410600T transposase HV181_08975 ENOG4105EY8 ABC transporter HV181_08980 ENOG4108KQJ Type 11 methyltransferase HV181_08990 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) HV181_09000 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase HV181_09015 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) HV181_09020 ENOG4105ECC imidazole-glycerol-phosphate dehydratase HV181_09025 ENOG4105CIH Imidazole acetol-phosphate transaminase HV181_09030 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) HV181_09045 ENOG4107SRH Nad-dependent epimerase dehydratase HV181_09050 ENOG4105EQ1 Transcriptional regulator HV181_09060 ENOG4105CUB amino acid HV181_09065 ENOG4105CUC YeeE YedE family protein HV181_09075 ENOG4105CJB Exodeoxyribonuclease I HV181_09080 ENOG4105DZ1 carboxypeptidase HV181_09090 ENOG4105DR8 Membrane HV181_09135 ENOG4105MAW Antitoxin component of a toxin-antitoxin (TA) module. Labile antitoxin that counteracts the effect of the CbtA (YeeV) toxin. It does not bind to the cognate toxin but instead binds to MreB and FtsZ (the toxin targets), enhancing their polymerization by forming higher-order bundles HV181_09145 ENOG4108YGG dna repair protein HV181_09150 ENOG4105MFG Antirestriction protein HV181_09155 ENOG4106H6R UPF0380 protein HV181_09165 ENOG4105F4K antigen 43 HV181_09250 ENOG4108YZT Adenosylcobinamide kinase HV181_09265 ENOG4108PXI ErfK YbiS YcfS YnhG HV181_09275 ENOG4106P55 Transcriptional regulator HV181_09280 ENOG4107R11 Transcriptional regulator HV181_09290 ENOG4105UQX Mate efflux family protein HV181_09300 ENOG4105CDY transcriptional regulatory protein HV181_09305 ENOG4105FYV Amp nucleosidase HV181_09310 ENOG4105CSH Transporter HV181_09325 ENOG4105EKQ RNA-directed DNA polymerase HV181_09360 ENOG4108YXQ IS66 Orf2 family protein HV181_09370 ENOG4108VKM cytochrome b561 HV181_09375 ENOG4108MEK Metal-binding protein YodA HV181_09390 ENOG4105VT2 5-hydroxyisourate hydrolase HV181_09395 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HV181_09400 ENOG4107ZY3 Histidine kinase HV181_09415 ENOG4105FCK Membrane HV181_09420 ENOG4105Y0K Inner membrane protein YedR HV181_09425 ENOG4105EST Metal Dependent Phosphohydrolase HV181_09430 ENOG4105DVF Cytosine-specific methyltransferase HV181_09435 ENOG41090BB DNA mismatch endonuclease (vsr) HV181_09440 ENOG4105FDR Membrane HV181_09445 ENOG4105CKW Inner membrane protein yedI HV181_09450 ENOG4105VNZ cytoplasmic protein HV181_09465 ENOG4105YX3 cellular response to acidity HV181_09475 ENOG4107TKS colanic acid capsular biosynthesis activation protein A HV181_09480 ENOG4105D19 Role in flagellar biosynthesis (By similarity) HV181_09490 ENOG4105CN7 Flagellar biosynthetic protein FliP HV181_09495 ENOG4105K0P flagellar biosynthesis protein HV181_09500 ENOG4105DD5 Flagellar motor switch protein HV181_09505 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) HV181_09510 ENOG4107ZI8 flagellar basal body-associated protein flil HV181_09515 ENOG4105WF4 Flagellar hook-length control protein HV181_09520 ENOG4105GSA Flagellar export protein flij HV181_09525 ENOG4108JIR Flagellum-specific ATP synthase HV181_09530 ENOG41090PJ Flagellar assembly protein HV181_09535 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) HV181_09540 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) HV181_09545 ENOG4105VQ0 flagellar hook-basal body complex protein fliE HV181_09550 ENOG410814C multidrug resistance protein HV181_09555 ENOG4108V1U phospholipid-binding protein HV181_09560 ENOG4108UQN AraC family transcriptional regulator HV181_09570 ENOG4105D7V transposase HV181_09575 ENOG4105D7V transposase HV181_09580 ENOG4108RAV Conserved protein HV181_09590 ENOG41066VF YeeE YedE family protein HV181_09595 ENOG4108W9D (LipO)protein HV181_09600 ENOG4105E5K Alpha-amylase HV181_09610 ENOG4105MQ3 flagellar protein FliS HV181_09615 ENOG4105DTS flagellar hook-associated HV181_09620 ENOG4105I03 Flagellin HV181_09625 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HV181_09630 ENOG4108M9K flagella biosynthesis protein FliZ HV181_09635 ENOG4105EAB amino acid AbC transporter HV181_09640 ENOG4105K6H D-cysteine desulfhydrase HV181_09645 ENOG4105E5Q amino acid AbC transporter HV181_09650 ENOG4105CDA abc transporter atp-binding protein HV181_09655 ENOG4105VJY transcriptional regulator HV181_09660 ENOG4105XVG cytoplasmic protein HV181_09670 ENOG4105WH1 Two component transcriptional regulator luxr family HV181_09700 ENOG4106RHG Yeca family HV181_09705 ENOG4105E0U tyrosine-specific transport protein HV181_09710 ENOG4105VVZ metal-binding protein HV181_09715 ENOG41090A1 ferritin HV181_09720 ENOG4105P23 (LipO)protein HV181_09730 ENOG4105N4N Protein of unknown function (DUF2766) HV181_09735 ENOG4108UEC Ferritin-like protein HV181_09740 ENOG4105DMK Periplasmic binding protein LacI transcriptional regulator HV181_09745 ENOG4105C2J ABC transporter HV181_09750 ENOG4105CNN ABC, transporter HV181_09755 ENOG4108K4C ec 3.1.3.12 HV181_09765 ENOG4108VA4 Universal stress protein HV181_09775 ENOG4106CIA Functions in complex with FlhD as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region HV181_09780 ENOG4107RD7 Flagellar Motor Protein, MotA HV181_09785 ENOG4105ER2 Ompa motb domain protein HV181_09790 ENOG4105CBS Chea signal transduction histidine kinase HV181_09795 ENOG4108V3W Chemotaxis protein, CheW HV181_09800 ENOG4105C8Q Methyl-accepting chemotaxis HV181_09805 ENOG4105C8Q Methyl-accepting chemotaxis HV181_09810 ENOG4105BZU Histidine kinase HV181_09815 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) HV181_09820 ENOG4108VYJ response regulator receiver protein HV181_09825 ENOG4108KCC Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P) (By similarity) HV181_09830 ENOG4105D00 flagellar biosynthetic protein flhB HV181_09835 ENOG4105D7B Flagellar biosynthesis protein flha HV181_09840 ENOG4105W13 flagellar protein HV181_09850 ENOG4105C75 arginyL-tRNA synthetase HV181_09855 ENOG4106ZCM YecM protein HV181_09865 ENOG4105CUW cytochrome C-TYPE protein HV181_09870 ENOG4107QY8 reductase HV181_09880 ENOG4105DA6 Catalyzes the conversion of 5-methoxyuridine (mo5U) to uridine-5-oxyacetic acid (cmo5U) at position 34 in tRNA. May also participate in the methylation of uridine-5-oxyacetic acid (cmo5U) to uridine-5-oxyacetic acid methyl ester (mcmo5U) (By similarity) HV181_09885 ENOG4105WJG Glutathione HV181_09890 ENOG41081XQ Conserved Protein HV181_09895 ENOG4105D3W isochorismatase HV181_09905 ENOG4108TIT dATP pyrophosphohydrolase HV181_09910 ENOG4105CDY transcriptional regulatory protein HV181_09920 ENOG4107S01 Repressor protein MetJ HV181_09940 ENOG4105FAV ABC, transporter HV181_09950 ENOG4105NXV High-affinity zinc uptake system protein HV181_09955 ENOG4105DR5 peptidase HV181_09960 ENOG4105NWR lipid A biosynthesis (Kdo)2-(Lauroyl)-lipid IVA acyltransferase HV181_09965 ENOG4105CA9 Pyruvate kinase HV181_09970 ENOG4106KNT transcriptional regulator HV181_09975 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase HV181_09980 ENOG4105C01 Dihydroxy-acid dehydratase HV181_09985 ENOG4108UHU Aldolase HV181_09995 ENOG4105X2V dna damage-inducible protein HV181_10005 ENOG4108Q2J Inner membrane protein YebE HV181_10010 ENOG4105CUG Oligopeptidase b HV181_10015 ENOG4105UMD exodeoxyribonuclease X HV181_10020 ENOG4108YGA nitrilase cyanide hydratase and apolipoprotein n-acyltransferase HV181_10025 ENOG4105MPK DNA polymerase III subunit theta HV181_10030 ENOG4105FXM Copper resistance protein HV181_10035 ENOG4108PNC copper resistance HV181_10040 ENOG4105NKT exported protein HV181_10045 ENOG4108R1E Serine threonine protein phosphatase 1 HV181_10050 ENOG4105UVW uncharacterized protein yebW HV181_10055 ENOG4105WT8 Protein of unknown function (DUF1480) HV181_10065 ENOG4105DY2 Paraquat-inducible protein b HV181_10070 ENOG4105H2K paraquat-inducible protein a HV181_10075 ENOG4108ZGC gaf domain protein HV181_10085 ENOG4105CN1 protease HV181_10095 ENOG4105C0R drug resistance transporter emrb qaca subfamily HV181_10100 ENOG4105J4Q Transcriptional regulator HV181_10105 ENOG4105TIK HV181_10115 ENOG4105Q3Y exported protein HV181_10130 ENOG4105DHI Methyltransferase HV181_10145 ENOG4105F3R pts system mannose fructose sorbose family iid HV181_10150 ENOG4105ETZ PTS System HV181_10155 ENOG4105DAS pts system HV181_10160 ENOG4105EE5 Membrane protein terC HV181_10165 ENOG4107XTP (EAL) domain protein HV181_10170 ENOG4105EJQ L-serine dehydratase HV181_10180 ENOG4105CRQ synthase (Component I) HV181_10190 ENOG4105V2F Uncharacterized protein yoac HV181_10195 ENOG4105M4H endoribonuclease L-psp HV181_10200 ENOG4105DVT helicase HV181_10205 ENOG41072GX Peptidase M22 Glycoprotease HV181_10210 ENOG4105Y4Z Outer Membrane Lipoprotein HV181_10215 ENOG4105CEY Amp-dependent synthetase and ligase HV181_10220 ENOG4105ZIE Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity) HV181_10225 ENOG4105E3J oxidoreductase HV181_10230 ENOG4105DVW rieske (2Fe-2S) HV181_10235 ENOG4105C94 Transporter HV181_10240 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) HV181_10245 ENOG4105EJC lysr family transcriptional regulator HV181_10255 ENOG4108YS1 cytoplasmic protein HV181_10260 ENOG4105YP6 Domain of unknown function (DUF1869) HV181_10265 ENOG4105Y3U Transglycosylase-associated protein HV181_10275 ENOG4106G4W HV181_10280 ENOG410620I Diguanylate cyclase HV181_10285 ENOG4105UCG Domain of unknown function (DUF333) HV181_10290 ENOG4105K78 MarR family Transcriptional regulator HV181_10295 ENOG4105DJ2 Major Facilitator Superfamily HV181_10300 ENOG4105R1U AraC Family Transcriptional Regulator HV181_10315 ENOG4108KXH Ybak prolyl-tRNA synthetase associated HV181_10320 ENOG4108KHP Diguanylate cyclase HV181_10325 ENOG4106KTS Inner membrane protein yeaI HV181_10335 ENOG4105CYN Serine protein kinase HV181_10340 ENOG4105GNX MltA-interacting MipA family protein HV181_10345 ENOG4105CV8 reductase HV181_10350 ENOG4105DSB aldose 1-epimerase HV181_10355 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase HV181_10365 ENOG4105VUT cytoplasmic protein HV181_10370 ENOG4105CPQ Dehydrogenase HV181_10375 ENOG4107TE1 transport protein HV181_10380 ENOG4105CPQ Dehydrogenase HV181_10385 ENOG4105D2N Aldolase HV181_10395 ENOG4105CPC Aldo Keto reductase HV181_10400 ENOG4105E98 transcriptional regulator DeoR family HV181_10405 ENOG4108KUU Inner membrane metabolite transport protein ydjE HV181_10410 ENOG4108RWI nicotinamidase HV181_10415 ENOG4105HDK L-asparaginase HV181_10420 ENOG4105D07 Signal peptide peptidase, SppA HV181_10425 ENOG41069NU Nitroreductase HV181_10435 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) HV181_10440 ENOG41065FB inner membrane protein ynji HV181_10445 ENOG4105D82 Glutamate dehydrogenase HV181_10450 ENOG4105MTM Protein of unknown function (DUF1496) HV181_10455 ENOG4105M6F mutator MutT protein HV181_10460 ENOG4108T9J Cdp-alcohol phosphatidyltransferase HV181_10465 ENOG4107RM6 sulfurtransferase HV181_10470 ENOG4108VGW abc transporter atp-binding protein HV181_10475 ENOG4105CXZ ABC transporter, permease HV181_10480 ENOG4105VNH ABC transporter solute-binding protein HV181_10485 ENOG4107ZN8 Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) HV181_10490 ENOG4108N5C SNARE associated Golgi protein-related protein HV181_10495 ENOG4108KCW iron-sulfur cluster binding HV181_10500 ENOG4108RSN SNARE associated Golgi HV181_10505 ENOG4105CGK Exodeoxyribonuclease III HV181_10535 ENOG4108SPG Periplasmic Protein HV181_10545 ENOG4105DKD Incises the DNA at the 3' side of a lesion during nucleotide excision repair. Incises the DNA farther away from the lesion than UvrC. Not able to incise the 5' site of a lesion. When a lesion remains because UvrC is not able to induce the 3' incision, Cho incises the DNA. Then UvrC makes the 5' incision. The combined action of Cho and UvrC broadens the substrate range of nucleotide excision repair (By similarity) HV181_10555 ENOG4105KKI DNA-binding transcriptional activator OsmE HV181_10560 ENOG4105VZJ PTS System HV181_10565 ENOG4105CK1 PTS System HV181_10570 ENOG4105VCP PTS System HV181_10575 ENOG4105EZV Transcriptional regulator HV181_10580 ENOG4105F8D glycoside hydrolase family 4 HV181_10590 ENOG4105CH6 catalase HV181_10605 ENOG4108ETY sodium dicarboxylate symporter HV181_10610 ENOG4107K5X Membrane-bound metal-dependent hydrolase HV181_10615 ENOG4107UW8 HAD-superfamily hydrolase subfamily IA variant 3 HV181_10620 ENOG4107PN8 YfeABCD locus regulator HV181_10630 ENOG4105P10 Uncharacterized protein ydiZ HV181_10635 ENOG4105DE4 1-phosphofructokinase HV181_10640 ENOG4108NE3 Salt-induced outer membrane protein HV181_10660 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) HV181_10665 ENOG41082NX 50s ribosomal protein l35 HV181_10700 ENOG4108V06 Glutathione peroxidase HV181_10710 ENOG4108QBX (LipO)protein HV181_10715 ENOG4108TC0 Diguanylate phosphodiesterase HV181_10730 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) HV181_10740 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) HV181_10745 ENOG4105CEY Amp-dependent synthetase and ligase HV181_10750 ENOG41090P5 ferredoxin-like protein HV181_10755 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase HV181_10760 ENOG4105C10 Electron transfer flavoprotein HV181_10765 ENOG4105CV7 Electron transfer flavoprotein HV181_10770 ENOG4105W4W Transcriptional regulator HV181_10775 ENOG4105C1G acyl-Coa dehydrogenase HV181_10780 ENOG4108IIG CoA transferase having broad substrate specificity for short-chain acyl-CoA thioesters with the activity decreasing when the length of the carboxylic acid chain exceeds four carbons (By similarity) HV181_10795 ENOG4105EMV Major Facilitator HV181_10800 ENOG4105EMV Major Facilitator HV181_10805 ENOG4105SUA Ydil protein HV181_10815 ENOG4105IPI Membrane HV181_10820 ENOG4105CQB FAD linked oxidase domain protein HV181_10825 ENOG4105KA0 thioesterase Superfamily protein HV181_10830 ENOG410671Z uncharacterized protein ydiH HV181_10835 ENOG4108Z4V iron-sulfur cluster assembly HV181_10840 ENOG4105DIW FeS assembly protein SUFB HV181_10845 ENOG4105C3K feS assembly ATPase SufC HV181_10850 ENOG4105JRK feS assembly protein SufD HV181_10865 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein HV181_10870 ENOG4105KMX major outer membrane lipoprotein HV181_10875 ENOG4105CA9 Pyruvate kinase HV181_10880 ENOG4105RFR Protein of unknown function (DUF2767) HV181_10885 ENOG4108PU5 4fe-4S ferredoxin, iron-sulfur binding domain protein HV181_10890 ENOG4105WE2 aldehyde ferredoxin oxidoreductase HV181_10895 ENOG4105JVW HV181_10900 ENOG4108393 oxidoreductase Fe-S subunit HV181_10905 ENOG4108NWD Cytochrome HV181_10910 ENOG4108Y7C Conserved Protein HV181_10915 ENOG4108KTU conserved protein with FAD NAD(P)-binding domain HV181_10920 ENOG4105N0V mono-oxygenase ydhR HV181_10945 ENOG4108R6K riboflavin synthase, subunit alpha HV181_10950 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase HV181_10955 ENOG4105CZQ inner membrane transport protein YdhC HV181_10960 ENOG4105F52 Transcriptional regulator HV181_10975 ENOG4105F27 Major Facilitator HV181_10980 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) HV181_10985 ENOG4105K4H Nlp p60 protein HV181_10990 ENOG4105M2J Glutaredoxin HV181_10995 ENOG4107QRT dEAD DEAH box helicase HV181_11005 ENOG4108UYE Lactoylglutathione lyase HV181_11010 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HV181_11015 ENOG4108WUH Transcriptional regulator, TetR family HV181_11020 ENOG4105XZD Fe-S protein HV181_11025 ENOG4107RGM aldo keto reductase HV181_11030 ENOG4108Z7T Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) HV181_11035 ENOG4105DSW Fusaric acid resistance protein HV181_11040 ENOG4105Y49 secretion protein, HlyD family HV181_11055 ENOG4108XTF Outer Membrane Lipoprotein HV181_11065 ENOG410642K Lysozyme inhibitor HV181_11080 ENOG4107XGF functions in a salvage pathway. Uses pyridoxamine (By similarity) HV181_11085 ENOG4108K3A Glutathione S-transferase HV181_11090 ENOG4105DUX Transporter HV181_11095 ENOG4105CSM endonuclease III HV181_11105 ENOG4108UQQ Electron transport complex HV181_11130 ENOG4105M9B inner membrane protein ydgK HV181_11135 ENOG4105QZ5 OriC-binding nucleoid-associated protein HV181_11140 ENOG4106C6R beta-lactam resistance protein HV181_11145 ENOG4105D9R oxidoreductase HV181_11155 ENOG4105C87 Aminotransferase class I and II HV181_11160 ENOG4105CI1 PTS System HV181_11165 ENOG4107P2S Transcriptional regulator HV181_11170 ENOG4107ZQV short-chain dehydrogenase reductase HV181_11180 ENOG4105CNT hydrolase family 2 HV181_11185 ENOG4105CT4 transporter HV181_11190 ENOG4108QNI outer membrane porin protein HV181_11195 ENOG4106J39 exported protein HV181_11200 ENOG4105EIP mannose-6-phosphate isomerase HV181_11205 ENOG4107GFK fumarate HV181_11210 ENOG4105C9Q fumarate hydratase class II HV181_11220 ENOG4105JJR Histidine kinase HV181_11225 ENOG4107EXC regulatoR HV181_11230 ENOG4105RA2 Membrane HV181_11240 ENOG4105D5Q Arginine ornithine antiporter HV181_11245 ENOG4105C5D exported protein HV181_11250 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) HV181_11255 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) HV181_11260 ENOG4105DSF transport protein HV181_11275 ENOG4105CVW peptidase s1 and s6 chymotrypsin hap HV181_11290 ENOG4105D94 Major Facilitator Superfamily HV181_11295 ENOG4106NZI LysR family Transcriptional regulator HV181_11300 ENOG4105DAG ROK family HV181_11305 ENOG4105EWW Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) HV181_11315 ENOG4108NEM leader-binding protein dmsD HV181_11320 ENOG4107KGK dmso reductase anchor subunit HV181_11325 ENOG4105QAX Iron-sulfur HV181_11330 ENOG4105C3J Cysteine desulfurase HV181_11335 ENOG4107QY8 reductase HV181_11340 ENOG4105KBG Protein of unknown function (DUF1161) HV181_11345 ENOG4105D69 UPF0257 lipoprotein ynfC HV181_11350 ENOG4108MK9 spermidine N(1)-acetyltransferase HV181_11365 ENOG4105CXK mandelate racemase muconate lactonizing HV181_11370 ENOG4105CPQ Dehydrogenase HV181_11380 ENOG4107R08 Integrase HV181_11395 ENOG4106G8A Qin prophage HV181_11415 ENOG41087BU transcriptional repressor DicA HV181_11480 ENOG4108MXB Protein of unknown function (DUF968) HV181_11485 ENOG4105HGD Antitermination protein HV181_11500 ENOG4105VEQ Cold shock protein HV181_11505 ENOG4105QFS Lysis protein S homolog from lambdoid prophage HV181_11520 ENOG4108YV9 Protein of unknown function (DUF2514) HV181_11525 ENOG4105VEQ Cold shock protein HV181_11540 ENOG4106IAW HV181_11545 ENOG4106H71 Overexpression increases levels of unsaturated fatty acids and suppresses both the temperature-sensitive fabA6 mutation and cold-sensitive secG null mutation HV181_11550 ENOG41064WM Uncharacterized protein YcgX HV181_11555 ENOG4106YSC HV181_11560 ENOG4105FKG DNA packaging protein HV181_11565 ENOG4105UZW Tail fiber assembly protein HV181_11570 ENOG4107DE1 head-to-tail joining protein HV181_11580 ENOG4105F7J membrane-bound serine protease HV181_11590 ENOG4105IM0 capsid protein HV181_11665 ENOG4108X9F tail fiber protein HV181_11670 ENOG4105UZW Tail fiber assembly protein HV181_11675 ENOG4105MN3 Resolvase HV181_11680 ENOG4105W3V DNA-binding, transcriptional regulator HV181_11690 ENOG4107R08 Integrase HV181_11705 ENOG4106G8A Qin prophage HV181_11725 ENOG41087BU transcriptional repressor DicA HV181_11780 ENOG4105K4U addiction module toxin, RelE StbE family HV181_11800 ENOG4108MXB Protein of unknown function (DUF968) HV181_11805 ENOG4105HGD Antitermination protein HV181_11820 ENOG4105VEQ Cold shock protein HV181_11825 ENOG4105QFS Lysis protein S homolog from lambdoid prophage HV181_11840 ENOG4108YV9 Protein of unknown function (DUF2514) HV181_11845 ENOG4105VEQ Cold shock protein HV181_11860 ENOG4106IAW HV181_11865 ENOG4106H71 Overexpression increases levels of unsaturated fatty acids and suppresses both the temperature-sensitive fabA6 mutation and cold-sensitive secG null mutation HV181_11870 ENOG41064WM Uncharacterized protein YcgX HV181_11875 ENOG4106YSC HV181_11880 ENOG4105FKG DNA packaging protein HV181_11885 ENOG4105UZW Tail fiber assembly protein HV181_11890 ENOG4107DE1 head-to-tail joining protein HV181_11900 ENOG4105F7J membrane-bound serine protease HV181_11910 ENOG4105IM0 capsid protein HV181_11985 ENOG4108X9F tail fiber protein HV181_11990 ENOG4105UZW Tail fiber assembly protein HV181_11995 ENOG4105MN3 Resolvase HV181_12000 ENOG4105W3V DNA-binding, transcriptional regulator HV181_12015 ENOG4105DEI Mannitol dehydrogenase HV181_12020 ENOG41061EV selenium-binding protein YdfZ HV181_12025 ENOG4107XBN GntR Family Transcriptional Regulator HV181_12030 ENOG4105EMU Dehydrogenase HV181_12035 ENOG4105DGW oligopeptidase A HV181_12040 ENOG4108WTK competence damage-inducible protein HV181_12045 ENOG4108YDI single-species biofilm formation on inanimate substrate HV181_12050 ENOG4105FSR swimming returnes to normal when residues 206-207 are both mutated to Ala. Overexpression also leads to a reduction in flagellar abundance and a 20-fold increase in c-di- GMP levels in vivo. Required for aminoglycoside-mediated induction of biofilm formation, it also plays a lesser role in biofilm production in response to other classes of translation inhibitors. The c-di-GMP produced by this enzyme up-regulates poly-GlcNAc production as well as the biofilm synthesis protein PgaD, although c-di-GMP is probably not the main inducing principle. Cyclic-di- GMP is a second messenger which controls cell surface-associated traits in bacteria HV181_12060 ENOG4105E5W Transporter HV181_12065 ENOG4108594 Permease of the drug metabolite transporter HV181_12070 ENOG4105FDP GntR family transcriptional regulator HV181_12080 ENOG4105CK1 PTS System HV181_12085 ENOG4105VCP PTS System HV181_12095 ENOG4105CS2 ec 3.2.1.21 HV181_12100 ENOG4106DNR multiple antibiotic resistance protein HV181_12105 ENOG4108XW0 May be a transcriptional activator of genes involved in the multiple antibiotic resistance (Mar) phenotype. It can also activate genes such as sodA, zwf and micF HV181_12110 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes HV181_12130 ENOG4105EGI Transcriptional regulator HV181_12135 ENOG4105C26 Dehydrogenase HV181_12140 ENOG4105CSV Glutaminase HV181_12145 ENOG4105M0C cytoplasmic protein HV181_12150 ENOG4105BZU Histidine kinase HV181_12160 ENOG4105FFC UPF0187 protein HV181_12165 ENOG4107R6G Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate (By similarity) HV181_12170 ENOG4105K34 Involved in the degradation of phospho-AI-2, thereby terminating induction of the lsr operon and closing the AI-2 signaling cycle. Catalyzes the cleavage of phosphorylated 4,5- dihydroxy-2,3-pentanedione (P-DPD) to 2-phosphoglycolic acid (PG) and another three-carbon compound HV181_12195 ENOG4105C2J ABC transporter HV181_12215 ENOG41061P8 Persistence to inhibition of murein or DNA biosynthesis regulatory protein HV181_12220 ENOG4105CAF HipA N-terminal domain protein HV181_12230 ENOG4108RQP Major type 1 subunit fimbrin HV181_12240 ENOG4105CW0 outer membrane usher protein HV181_12245 ENOG4108WDE Fimbrial protein HV181_12250 ENOG4106318 fimbrial-like protein YdeR HV181_12255 ENOG4106PIH fimbrial-like protein ydeQ HV181_12260 ENOG4107QKC Oxidoreductase alpha (molybdopterin) subunit HV181_12275 ENOG4105ENH Sulfatase HV181_12280 ENOG4105C4X radical SAM domain protein HV181_12290 ENOG4105CQ0 ABC transporter HV181_12295 ENOG4105PE1 Receptor HV181_12300 ENOG4107RAN Peptidase, M16 HV181_12305 ENOG4105CVK Glutamate decarboxylase HV181_12310 ENOG4105E5D amino acid HV181_12315 ENOG4105F32 YngK protein HV181_12330 ENOG4105BZU Histidine kinase HV181_12335 ENOG4108UQS dipeptidase HV181_12340 ENOG4105DEF Extracellular solute-binding protein, family 5 HV181_12345 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HV181_12350 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HV181_12355 ENOG4105C3U ABC transporter HV181_12360 ENOG4107H6U ABC transporter HV181_12365 ENOG4108Z9K Osmotically inducible protein HV181_12370 ENOG4105TPS biofilm-dependent modulation protein HV181_12375 ENOG4107AV5 Although this protein associates with the 30S subunit of the ribosome it is not considered to be a bona fide ribosomal protein HV181_12385 ENOG4105DQ4 alcohol dehydrogenase HV181_12390 ENOG41084S7 Plasmid maintenance system antidote protein HV181_12395 ENOG4108MG3 formate dehydrogenase HV181_12400 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein HV181_12410 ENOG4105RPH Inner membrane protein YddG HV181_12425 ENOG4107QND Nitrite extrusion protein HV181_12430 ENOG4105CRU nitrate reductase, alpha subunit HV181_12435 ENOG4108IUE nitrate reductase beta subunit HV181_12440 ENOG4108NZN Respiratory nitrate reductase 2 delta chain HV181_12445 ENOG4105D0D Nitrate reductase 2, gamma subunit HV181_12450 ENOG4105JAB phenazine biosynthesis protein, phzf family HV181_12455 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase HV181_12460 ENOG4108MEJ flavin reductase domain protein HV181_12495 ENOG410600T transposase HV181_12515 ENOG4105CNA YD repeat protein HV181_12520 ENOG4105CS6 Rhs element vgr protein HV181_12530 ENOG4108N27 Glutathione S-transferase HV181_12535 ENOG4105C85 amino acid HV181_12540 ENOG4108NS2 receptor HV181_12545 ENOG4105CHB tonB-dependent Receptor HV181_12550 ENOG4108WYP Transcriptional regulator HV181_12555 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein HV181_12560 ENOG4108Z7F N-acetyltransferase HV181_12565 ENOG4108T9Y Inner membrane protein ydcZ HV181_12570 ENOG4105R71 cytoplasmic protein HV181_12575 ENOG410654E Membrane HV181_12590 ENOG4105NRK Binding-protein-dependent transport systems, inner membrane component HV181_12595 ENOG4105D81 ABC transporter, permease HV181_12600 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HV181_12605 ENOG4107TYH extracellular solute-binding protein family 1 HV181_12610 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HV181_12615 ENOG4105PF0 Antitoxin component of a toxin-antitoxin (TA) module. Functions as an mRNA interferase antitoxin HV181_12625 ENOG4105RR0 Protein of unknown function (DUF2554) HV181_12630 ENOG4105CFP Peptidase U32 HV181_12635 ENOG4108JCI Transcriptional regulator HV181_12640 ENOG4105DKK Benzoate HV181_12645 ENOG4105D7V transposase HV181_12655 ENOG4108KKZ (LipO)protein HV181_12660 ENOG41088CC tellurite resistance protein tehB HV181_12665 ENOG4108NKP c4-dicarboxylate transporter malic acid transport protein HV181_12670 ENOG4107WE3 acetyltransferase YdcK HV181_12675 ENOG4108Z9I -acetyltransferase HV181_12680 ENOG4105Z2P Protein of unknown function (DUF465) HV181_12690 ENOG4105E32 cytoplasmic protein HV181_12695 ENOG4105DDW LysR family Transcriptional regulator HV181_12700 ENOG4105C8Q Methyl-accepting chemotaxis HV181_12705 ENOG4107NK6 Hok/gef family HV181_12710 ENOG4105UPP uncharacterized protein ydcA HV181_12715 ENOG4105CPW cytochrome b561 HV181_12725 ENOG4105C26 Dehydrogenase HV181_12730 ENOG4107DB1 DUF218 domain HV181_12735 ENOG4105CQ7 ATP-dependent helicase HV181_12745 ENOG41077RS Phosphatase HV181_12750 ENOG4105E8V Alpha Beta Hydrolase Fold protein HV181_12755 ENOG4108HPI phosphatidate Cytidylyltransferase HV181_12760 ENOG4108UMZ Cdp-alcohol phosphatidyltransferase HV181_12765 ENOG4107S5I aldo keto reductase HV181_12770 ENOG4108Z0R Transferase HV181_12775 ENOG4105V9J phenylacetic acid degradation operon negative regulatory protein HV181_12780 ENOG4105DZS Phenylacetate-CoA ligase HV181_12785 ENOG4105CHU acetyl-coa acetyltransferase HV181_12790 ENOG4108ZJI phenylacetic acid degradation protein HV181_12795 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase HV181_12800 ENOG4108UKI Enoyl-CoA hydratase HV181_12805 ENOG4105E39 Enoyl-CoA hydratase HV181_12810 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) HV181_12815 ENOG4108ZA2 phenylacetate-CoA oxygenase PaaJ subunit HV181_12820 ENOG4105D9S phenylacetate-CoA oxygenase PaaI subunit HV181_12825 ENOG4105N76 Phenylacetate-CoA oxygenase, subunit HV181_12830 ENOG4105CRS phenylacetate-CoA oxygenase PaaG subunit HV181_12835 ENOG4105DXM phenylacetic acid degradation protein HV181_12840 ENOG4105F11 amine oxidase HV181_12845 ENOG4105C26 Dehydrogenase HV181_12850 ENOG4108WFR AraC Family Transcriptional Regulator HV181_12855 ENOG4105WXT Conserved Protein HV181_12860 ENOG410689M (LipO)protein HV181_12865 ENOG4107H52 Dicarboxylate transport HV181_12870 ENOG4105C5I Dehydrogenase HV181_12875 ENOG41090X5 Heat shock protein hslJ HV181_12880 ENOG4105IKK cytoplasmic protein HV181_12885 ENOG4105D95 Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity) HV181_12890 ENOG4105FCK Membrane HV181_12895 ENOG4108RW8 Universal stress protein F HV181_12905 ENOG4105C1J atp-dependent rna helicase HV181_12915 ENOG4105BZU Histidine kinase HV181_12920 ENOG4108DG9 Smr protein MutS2 HV181_12925 ENOG4106KR7 LysR family Transcriptional regulator HV181_12930 ENOG4105CH2 amidohydrolase HV181_12935 ENOG4107RT5 aminobenzoyl-glutamate utilization protein B HV181_12940 ENOG4105CFC Transporter HV181_12945 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) HV181_12950 ENOG4105DS0 Transcriptional regulator, Crp Fnr family HV181_12955 ENOG4105Q9Y Universal stress protein HV181_12960 ENOG4105S5I Membrane HV181_12965 ENOG4105D64 Mechanosensitive ion channel HV181_12970 ENOG4107QSI ABC, transporter HV181_12975 ENOG4105EQ2 LysR family Transcriptional regulator HV181_12980 ENOG4105ENX hydrolase HV181_12995 ENOG4105KXI murein peptide amidase A HV181_13000 ENOG4107S8C mandelate racemase muconate lactonizing HV181_13005 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) HV181_13010 ENOG4108JU8 Transcriptional regulator HV181_13020 ENOG4105CM6 amino acid regulated cytosolic protein HV181_13025 ENOG4105FKQ transcriptional regulator HV181_13030 ENOG4107EFV Outer membrane protein G HV181_13035 ENOG4108IJ9 (ABC) transporter HV181_13040 ENOG4107URF beta-phospho-glucomutase HV181_13045 ENOG4105C71 hydrolase family 65, central catalytic HV181_13050 ENOG4105CK5 oxidoreductase HV181_13055 ENOG4107TYA transient receptor potential locus HV181_13060 ENOG4107RRD Dehydrogenase HV181_13070 ENOG4105HS6 binding-protein-dependent transport systems inner membrane Component HV181_13075 ENOG4105WEM extracellular solute-binding protein HV181_13080 ENOG4107QW3 Sucrose phosphorylase HV181_13085 ENOG4105K8Z Phage shock protein HV181_13090 ENOG4105NNG Peripheral inner membrane phage-shock protein HV181_13095 ENOG4105FM1 phage shock protein C HV181_13100 ENOG4105YYT phage shock protein B HV181_13105 ENOG41087YS Phage shock protein A HV181_13110 ENOG4105E51 psp operon transcriptional activator HV181_13115 ENOG4108JPW Aminotransferase HV181_13120 ENOG4105CJP fad dependent oxidoreductase HV181_13125 ENOG4105C26 Dehydrogenase HV181_13130 ENOG4107VRI Transcriptional regulator HV181_13135 ENOG4108Z86 Glutamine amidotransferase HV181_13140 ENOG4105CFQ glutamine synthetase HV181_13150 ENOG4105CUB amino acid HV181_13155 ENOG4105N0E Protein of unknown function (DUF2543) HV181_13160 ENOG4108HIY periplasmic HV181_13165 ENOG4108I5W peptide transport system, permease protein HV181_13170 ENOG4108EU3 peptide transport system, permease HV181_13175 ENOG4108JQ3 Peptide ABC transporter ATP-binding protein HV181_13180 ENOG4108JQ2 peptide transport system atp-binding protein HV181_13185 ENOG4105WDY DNA (cytosine-5-)-methyltransferase HV181_13190 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH HV181_13195 ENOG4105Q4T oxidoreductase HV181_13210 ENOG4105BZU Histidine kinase HV181_13215 ENOG410643D UPF0509 protein HV181_13220 ENOG4105N2W Transcriptional regulator HV181_13230 ENOG4108ZJT translation initiation factor, Sui1 HV181_13240 ENOG4105CFV Tetratricopeptide repeat protein HV181_13245 ENOG4105Q4A inner membrane protein yciS HV181_13250 ENOG4105EYK Phosphatidylglycerophosphatase B HV181_13260 ENOG4107QM5 aconitate hydratase HV181_13280 ENOG4107R11 Transcriptional regulator HV181_13285 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) HV181_13290 ENOG4105RKX Protein of unknown function (DUF2498) HV181_13295 ENOG4105ERU peptidase HV181_13300 ENOG4105UBK short-chain dehydrogenase reductase HV181_13305 ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase HV181_13310 ENOG4105FE9 pseudouridine synthase HV181_13315 ENOG4107RTD sua5 ycio yrdc ywlc family protein HV181_13320 ENOG4105DB7 PHP domain protein HV181_13330 ENOG4105CRQ synthase (Component I) HV181_13335 ENOG4108EFP Anthranilate synthase component II HV181_13340 ENOG4105DK0 Indole-3-glycerol phosphate synthase HV181_13360 ENOG4108Z9Z response to DNA damage stimulus HV181_13365 ENOG4108N8X transition metal ion binding HV181_13370 ENOG4105EIF outer membrane protein W HV181_13390 ENOG4105NAU thioesterase Superfamily protein HV181_13395 ENOG410822N TonB family HV181_13400 ENOG4105K9H YciI-like protein HV181_13405 ENOG4107SVH Potassium channel protein HV181_13425 ENOG4108JQ7 (ABC) transporter HV181_13430 ENOG4105C3U ABC transporter HV181_13435 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HV181_13440 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HV181_13445 ENOG4108J59 Extracellular solute-binding protein, family 5 HV181_13455 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein HV181_13460 ENOG4105C0A alcohol dehydrogenase HV181_13465 ENOG4105VNT transposase (IS4 family) protein HV181_13475 ENOG4108SAU DNA-binding protein H-ns HV181_13480 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase HV181_13485 ENOG4105I93 response regulator HV181_13490 ENOG4105D78 K07001 NTE family protein HV181_13495 ENOG4105K5B UPF0225 protein HV181_13500 ENOG4105CIY formyltetrahydrofolate deformylase HV181_13530 ENOG41076YT nitrate reductase, gamma subunit HV181_13535 ENOG4105R3A Nitrate reductase HV181_13540 ENOG4108IUE nitrate reductase beta subunit HV181_13545 ENOG4105CRU nitrate reductase, alpha subunit HV181_13550 ENOG4105DQQ Major facilitator superfamily MFS_1 HV181_13555 ENOG4105BZU Histidine kinase HV181_13560 ENOG4105WH1 Two component transcriptional regulator luxr family HV181_13565 ENOG4105ID0 Putative invasin HV181_13570 ENOG41090EX DsrE family HV181_13575 ENOG4108NH8 Cation transport protein HV181_13580 ENOG4105WS7 Cation transport regulator HV181_13585 ENOG4105EWV Sodium calcium exchanger membrane region HV181_13605 ENOG41063JG Transcriptional regulator HV181_13610 ENOG4108YY7 Invasion gene expression up-regulator SirB HV181_13625 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) HV181_13640 ENOG4105C5T Phosphoribosyl pyrophosphate synthase HV181_13645 ENOG4105CHH sulfate transporter HV181_13650 ENOG4105MGX transcription activated by CRP (cyclic AMP receptor protein), a global transcription factor involved in regulation of metabolism in enteric bacteria HV181_13660 ENOG4105C3G gtp-binding protein HV181_13665 ENOG4105I1J Autotransporter HV181_13670 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family HV181_13675 ENOG4105CMT Dihydroxyacetone kinase HV181_13680 ENOG4108UTZ Dihydroxyacetone kinase HV181_13685 ENOG4105VDH Dihydroxyacetone kinase HV181_13705 ENOG4108T7K Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Increasing levels of c-di-GMP lead to decreased motility (By similarity) HV181_13715 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A HV181_13725 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) HV181_13735 ENOG4105ED1 spovr family HV181_13750 ENOG410635M Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein (By similarity) HV181_13755 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) HV181_13760 ENOG4105KT5 UmuD protein HV181_13765 ENOG4106PXS Toxin, which has some hemolytic activity towards mammalian cells. Acts by forming a pore-like structure upon contact with mammalian cells HV181_13775 ENOG4105FBJ fumarylacetoacetate (faa) hydrolase HV181_13785 ENOG41066UD Inhibits activity of g-type lysozyme, which confers increased lysozyme tolerance to the bacterium HV181_13790 ENOG4105S66 prophage protein HV181_13800 ENOG4107QMS site-determining protein HV181_13830 ENOG410658X HV181_13845 ENOG4105BZU Histidine kinase HV181_13850 ENOG410738I uncharacterized protein ymgC HV181_13860 ENOG41077SS Probably a connector protein for RcsB C regulation of biofilm formation, providing additional signal input into the two- component signaling pathway. May serve to stimulate biofilm maturation, probably via the Rcs phosphorelay. Mild overexpression at 16 degrees Celsius increases the production of colanic acid, an exopolysaccharide and matrix component, and reduces adhesive curli fimbriae expression. Both of these effects require RcsB HV181_13865 ENOG4105WKE Probably a connector protein for RcsB C regulation of biofilm formation, providing additional signal input into the two- component signaling pathway. Partially antagonizes the activities of YmgA and AriR, proteins that, via the Rcs phosphorelay, promote the synthesis of colanic acid, an exopolysaccharide and matrix component HV181_13870 ENOG4105BZU Histidine kinase HV181_13875 ENOG4108XDN Transcriptional regulator HV181_13880 ENOG41064WM Uncharacterized protein YcgX HV181_13900 ENOG4108HMX isocitrate dehydrogenase (NADP) HV181_13905 ENOG4108R99 pseudouridine synthase HV181_13925 ENOG4107QTF adenylosuccinate lyase HV181_13930 ENOG4105XJC Two component transcriptional regulator (Winged helix family HV181_13935 ENOG4105IFJ Histidine kinase HV181_13940 ENOG4105EZE Cupin 4 family protein HV181_13960 ENOG4105D38 putrescine abc transporter HV181_13965 ENOG4107RUE extracellular solute-binding protein family 1 HV181_13980 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) HV181_13990 ENOG4105D60 lipoprotein releasing system transmembrane protein HV181_13995 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) HV181_14000 ENOG4105D60 lipoprotein releasing system transmembrane protein HV181_14005 ENOG4105IQC Inner membrane protein YcfT HV181_14010 ENOG4108JA2 transcriptioN-repair coupling factor HV181_14015 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein HV181_14020 ENOG4105RC8 Reduces the permeability of the outer membrane to copper. Seems to be involved in the regulation of biofilm formation. May decrease biofilm formation by repressing cell-cell interaction and cell surface interaction HV181_14025 ENOG4108IND Tetr family transcriptional regulator HV181_14030 ENOG4107MBR 17 kDa surface antigen HV181_14035 ENOG4105CEP NADH dehydrogenase HV181_14050 ENOG4108RUM thiamine kinase HV181_14055 ENOG4108WEF Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b) (By similarity) HV181_14060 ENOG41090DQ Lipoprotein HV181_14065 ENOG4105K59 histidine triad (HIT) protein HV181_14070 ENOG4105CNM Receptor HV181_14075 ENOG4105CI1 PTS System HV181_14080 ENOG4105F8V Hydrolase, tatD family HV181_14085 ENOG4107QRG dna polymerase iii HV181_14095 ENOG4105HHA aminodeoxychorismate lyase HV181_14100 ENOG4105YAZ 4-amino-4-deoxychorismate lyase HV181_14105 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) HV181_14110 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) HV181_14115 ENOG4105CHR reductase HV181_14120 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase HV181_14140 ENOG4105FCQ metal-binding, possibly nucleic acid-binding protein HV181_14145 ENOG4108UHJ MAF-like protein HV181_14150 ENOG4105EI2 Pseudouridine synthase HV181_14155 ENOG4107QQB Ribonuclease E HV181_14160 ENOG4105DTJ flagellar hook-associated protein HV181_14165 ENOG4105E1Q flagellar hook-associated protein HV181_14170 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj HV181_14185 ENOG4105CGA flagellar basal-body rod protein FlgG HV181_14190 ENOG4108KPB Flagellar basal-body rod protein FlgF HV181_14195 ENOG4105BZE flagellar hook protein, FlgE HV181_14200 ENOG4105W00 Flagellar hook capping protein HV181_14205 ENOG4108ZC9 flagellar basal-body rod protein flgc HV181_14210 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) HV181_14215 ENOG4105CKS Flagella basal body P-ring formation protein flgA HV181_14220 ENOG4105M9M anti-sigma28 factor FlgM HV181_14225 ENOG4105QVD Flagella synthesis protein FlgN HV181_14230 ENOG4105CJR Integral membrane protein (MviN HV181_14235 ENOG4105EP9 oxidoreductase HV181_14245 ENOG4105D9U N-acetyltransferase HV181_14255 ENOG4105E9S glutaredoxin 2 HV181_14260 ENOG4105F3T (LipO)protein HV181_14270 ENOG4105MEA DNA damage-inducible protein i HV181_14275 ENOG4105PVA Biofilm formation regulatory protein BssS HV181_14285 ENOG4106974 biofilm formation HV181_14290 ENOG4105DS1 cytochrome b561 HV181_14295 ENOG4108YYC ycei family HV181_14305 ENOG4105D1S lipid A biosynthesis HV181_14315 ENOG4108W47 Acidic protein msyB HV181_14320 ENOG4105NAC (LipO)protein HV181_14325 ENOG4105C3A Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs) (By similarity) HV181_14340 ENOG4107RZC phospholipase d HV181_14345 ENOG4108UVJ appr-1-p processing domain protein HV181_14360 ENOG4105G76 Curli are coiled surface structures that assemble preferentially at growth temperatures below 37 degrees Celsius. Curli can bind to fibronectin HV181_14365 ENOG4108U0V Curli are coiled surface structures that assemble preferentially at growth temperatures below 37 degrees Celsius. Curli can bind to fibronectin. The minor subunit is the nucleation component of curlin monomers HV181_14370 ENOG41086KC Transcriptional regulator HV181_14375 ENOG4108XDW curli assembly protein CsgE HV181_14380 ENOG4108WYR Curli production assembly transport component, CsgF HV181_14385 ENOG4105P8Q Curli production assembly transport component CsgG HV181_14390 ENOG4108UQ5 membrane protein YcdZ HV181_14395 ENOG4107XHZ cytoplasmic chaperone TorD family protein HV181_14425 ENOG4108T85 Membrane HV181_14440 ENOG4105BZU Histidine kinase HV181_14445 ENOG4108TUY outer membrane protein PgaA HV181_14450 ENOG4107BJW polysaccharide deacetylase HV181_14455 ENOG4105CND Glycosyl transferase, family 2 HV181_14465 ENOG4105D5M phosphate starvation-inducible protein HV181_14475 ENOG410650H (LipO)protein HV181_14485 ENOG4105CK7 Sodium proline symporter HV181_14490 ENOG4105C26 Dehydrogenase HV181_14495 ENOG4108R86 Transcriptional regulator HV181_14530 ENOG4105C2W permease HV181_14535 ENOG4105XF5 Escherichia coli IMT2125 genomic chromosome, IMT2125 HV181_14545 ENOG4105XH3 HV181_14550 ENOG4105D6F Phosphatase HV181_14575 ENOG4108J2R molybdopterin oxidoreductase HV181_14580 ENOG4105CUW cytochrome C-TYPE protein HV181_14585 ENOG4106WF9 DNA-binding transcriptional regulator TorR HV181_14590 ENOG4108SV3 Tmao reductase system periplasmic protein tort HV181_14595 ENOG4105BZU Histidine kinase HV181_14600 ENOG4105HEE Binding Domain protein HV181_14605 ENOG4106H71 Overexpression increases levels of unsaturated fatty acids and suppresses both the temperature-sensitive fabA6 mutation and cold-sensitive secG null mutation HV181_14620 ENOG4105VEQ Cold shock protein HV181_14625 ENOG41060EU Cold shock-like protein HV181_14635 ENOG4108Y9B (LipO)protein HV181_14640 ENOG4108W78 Pfam:DUF1017 HV181_14645 ENOG4105E3R (LipO)protein HV181_14650 ENOG4105DAY polysaccharide export protein HV181_14655 ENOG4107ZF2 Phosphatase HV181_14660 ENOG4108F2G Chain length determinant protein HV181_14665 ENOG4105D6F Phosphatase HV181_14675 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii HV181_14680 ENOG4105C4M (Ubiquinol oxidase) subunit I HV181_14685 ENOG4105MVP hydrogenase-1 operon protein HyaF HV181_14690 ENOG4108VXY Hydrogenase-1 operon protein HyaE HV181_14695 ENOG4108USZ hydrogenase HV181_14700 ENOG4105X7T Ni Fe-hydrogenase, b-type cytochrome subunit HV181_14705 ENOG4105DPX Hydrogenase, large subunit HV181_14710 ENOG4105E3S small subunit HV181_14720 ENOG4108MN8 Membrane HV181_14725 ENOG4108Z0T Part of a sulfur-relay system (By similarity) HV181_14730 ENOG4105VSY K01512 acylphosphatase EC 3.6.1.7 HV181_14745 ENOG4105K4P CoA-binding domain protein HV181_14760 ENOG41088T4 Helicase IV HV181_14765 ENOG410901E Membrane HV181_14770 ENOG4105EM2 membrane HV181_14775 ENOG4108RZ1 DNA transformation protein HV181_14785 ENOG4105UYK outer membrane protein a HV181_14795 ENOG4105DAN ATP-dependent protease HV181_14805 ENOG4105WFT During stationary phase, converts 70S ribosomes to an inactive dimeric form (100S ribosomes) (By similarity) HV181_14810 ENOG4108Q2G (LipO)protein HV181_14815 ENOG4105DY2 Paraquat-inducible protein b HV181_14820 ENOG4105F1S paraquat-inducible protein a HV181_14825 ENOG4105C5H ABC transporter HV181_14835 ENOG4105QVC MOSC domain-containing protein HV181_14840 ENOG4108T7E Contributes to the efficiency of the cell division process by stabilizing the polymeric form of the cell division protein FtsZ. Acts by promoting interactions between FtsZ protofilaments and suppressing the GTPase activity of FtsZ (By similarity) HV181_14850 ENOG4106PH7 chaperone HV181_14855 ENOG4105MX3 Fimbrial HV181_14860 ENOG4105Q7J Fimbrial HV181_14865 ENOG4108MDY Fimbrial HV181_14870 ENOG4105CW0 outer membrane usher protein HV181_14875 ENOG4106JJN Part of the elfADCG-ycbUVF fimbrial operon, which promotes adhesion of bacteria to different abiotic surfaces. Could be required for the biogenesis of the ElfA fimbriae HV181_14880 ENOG41071VI Part of the elfADCG-ycbUVF fimbrial operon, which promotes adhesion of bacteria to different abiotic surfaces. ElfA is the major fimbrial subunit produced by this operon HV181_14885 ENOG4108UZX fmn reductase HV181_14890 ENOG4105GVF (ABC) transporter HV181_14900 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component HV181_14910 ENOG4105CD8 aminopeptidase N HV181_14925 ENOG4105FCK Membrane HV181_14930 ENOG4105CGF Aromatic amino acid aminotransferase HV181_14935 ENOG4105C5X domain protein HV181_14940 ENOG4105EAQ (twin-arginine translocation) pathway signal HV181_14945 ENOG4105DIT ErfK YbiS YcfS YnhG family protein HV181_14955 ENOG4105DAH Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF (By similarity) HV181_14965 ENOG4106371 Methyltransferase HV181_14970 ENOG4107S90 membrAne HV181_14975 ENOG4107VR7 transferase activity, transferring phosphorus-containing groups HV181_14990 ENOG4105T0Z Conserved Protein HV181_15000 ENOG4105BZ1 (ABC) transporter HV181_15005 ENOG4108EQH DNA internalization-related competence protein ComEC Rec2 HV181_15015 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) HV181_15025 ENOG4108K0D peptidase, M48 HV181_15040 ENOG4107VMU Membrane HV181_15045 ENOG4105DDY UPF0142 protein ycaO HV181_15050 ENOG4105TMB Formate nitrite transporter HV181_15055 ENOG4105C6N Formate acetyltransferase HV181_15060 ENOG4105F1A Pyruvate formate-lyase HV181_15065 ENOG4108X0B nad(p)h dehydrogenase (quinone) HV181_15070 ENOG410642W LysR family Transcriptional regulator HV181_15075 ENOG4105E5D amino acid HV181_15085 ENOG4105CHJ isochorismatase hydrolase HV181_15090 ENOG4107KGK dmso reductase anchor subunit HV181_15095 ENOG4105QAX Iron-sulfur HV181_15100 ENOG4107QY8 reductase HV181_15110 ENOG4105D1H recombination factor protein RarA HV181_15120 ENOG4105CNU cell division protein FtsK HV181_15130 ENOG4105C3M thioredoxin reductase HV181_15135 ENOG4108JJ9 ABC, transporter HV181_15140 ENOG4108JJ8 (ABC) transporter HV181_15150 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) HV181_15160 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit HV181_15170 ENOG4105VEQ Cold shock protein HV181_15175 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) HV181_15180 ENOG4105DJY efflux transporter, rnd family, mfp subunit HV181_15185 ENOG4108MJ5 VirK protein HV181_15190 ENOG4105CPB ATP-dependent endonuclease of the OLD family HV181_15195 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) HV181_15200 ENOG4105DWU Membrane HV181_15210 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) HV181_15215 ENOG4105C7K acetolactate synthase HV181_15220 ENOG4105C5W Aldolase HV181_15225 ENOG4105CGD Nad-dependent epimerase dehydratase HV181_15230 ENOG4107VBM 3-beta hydroxysteroid dehydrogenase isomerase HV181_15235 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase HV181_15245 ENOG41064MM (LipO)protein HV181_15250 ENOG4105E5Z arginine transporter ATP-binding subunit HV181_15255 ENOG4106PMH Extracellular solute-binding protein family 3 HV181_15260 ENOG4105GBT ABC transporter HV181_15265 ENOG4105DMR ABC, transporter HV181_15270 ENOG4106TNF Periplasmic binding protein HV181_15280 ENOG4105RBQ inner membrane protein ybjO HV181_15285 ENOG4105D38 putrescine abc transporter HV181_15290 ENOG4105F38 ABC transporter, permease HV181_15295 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HV181_15300 ENOG4107RUE extracellular solute-binding protein family 1 HV181_15305 ENOG4108RMJ sensory transduction regulator HV181_15315 ENOG4108DBC nitroreductase HV181_15320 ENOG4105X20 member of the soxRS regulon which mediates in part the increased levels of superoxide in response to oxidative stress HV181_15325 ENOG41090BQ Glutaredoxin HV181_15330 ENOG4105GWF inner membrane protein YbjM HV181_15340 ENOG4108RFG Tetr family transcriptional regulator HV181_15345 ENOG4106UW1 Major Facilitator superfamily HV181_15350 ENOG4108HCJ Hydrolase HV181_15360 ENOG4107QF7 multi-drug HV181_15365 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase HV181_15370 ENOG4107FB0 transcriptional regulator DeoR family HV181_15375 ENOG4105DZ1 carboxypeptidase HV181_15380 ENOG4108TGY Glutathione S-transferase HV181_15385 ENOG4105D8V Glucose sorbosone dehydrogenase HV181_15390 ENOG4105UFT Represses biofilm formation in M9C glu and LB glu media but not in M9C and LB media. Seems to act as a global regulator of several genes involved in catabolite repression and stress response and regulation of the uptake and export of signaling pathways. Could be involved the regulation of indole as well as uptake and export of AI-2 through a cAMP-dependent pathway HV181_15400 ENOG41064RH membrane protein YliF HV181_15405 ENOG4105BZU Histidine kinase HV181_15430 ENOG4105D44 asparaginase HV181_15435 ENOG4105CVM Molybdenum cofactor synthesis domain protein HV181_15440 ENOG4105D06 uba thif-type nad fad binding protein HV181_15445 ENOG4107T9Z Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) HV181_15450 ENOG4105F1A Pyruvate formate-lyase HV181_15460 ENOG4108HCJ Hydrolase HV181_15465 ENOG41072TH Protein of unknown function (DUF1479) HV181_15470 ENOG4105C5H ABC transporter HV181_15475 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein HV181_15480 ENOG4105F4P )-transporter HV181_15485 ENOG4105KST dependent repressor HV181_15495 ENOG4108I6E Sulfatase HV181_15500 ENOG4108T1M outer membrane protein x HV181_15510 ENOG4107AQZ Membrane HV181_15520 ENOG4107R0W ABC transporter HV181_15525 ENOG4105E5Q amino acid AbC transporter HV181_15530 ENOG4105CDA abc transporter atp-binding protein HV181_15535 ENOG4105D8X mechanosensitive ion channel HV181_15545 ENOG4105ZY9 UPF0379 protein ybiM HV181_15550 ENOG4108IU3 tonb-dependent siderophore receptor HV181_15560 ENOG4105KSC Transcriptional regulator, TraR DksA family HV181_15565 ENOG4105VR4 UPF0379 protein ybiJ HV181_15570 ENOG4105DG4 malate L-lactate dehydrogenase HV181_15575 ENOG4108MTB glycosyl transferase family HV181_15580 ENOG4105DVT helicase HV181_15585 ENOG4108UV1 cellular component movement HV181_15590 ENOG4105C1J atp-dependent rna helicase HV181_15595 ENOG4107MVR Transcriptional regulator HV181_15605 ENOG4105CJ1 ABC, transporter HV181_15610 ENOG4107QWP ABC-2 type transporter HV181_15615 ENOG4107QWP ABC-2 type transporter HV181_15620 ENOG4105I9U inner membrane protein ybhQ HV181_15625 ENOG4105X23 Endonuclease Exonuclease phosphatase HV181_15630 ENOG4105DZQ phospholipase D Transphosphatidylase HV181_15635 ENOG4107UXM Membrane HV181_15640 ENOG410733J conserved inner membrane protein HV181_15645 ENOG4105HFZ Membrane HV181_15650 ENOG4108ZAF Molybdopterin HV181_15655 ENOG4105M00 molybdopterin converting factor, subunit 1 HV181_15665 ENOG4108RIR Molybdenum cofactor biosynthesis protein HV181_15675 ENOG4105CHW UPF0052 protein HV181_15685 ENOG4105E78 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) HV181_15690 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) HV181_15695 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) HV181_15705 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) HV181_15710 ENOG4108V1U phospholipid-binding protein HV181_15715 ENOG4105NBR Pectinesterase HV181_15720 ENOG4107QM5 aconitate hydratase HV181_15725 ENOG4107QPK )-transporter HV181_15730 ENOG4105C7F AcnD-accessory protein PrpF HV181_15735 ENOG4105F04 LysR family Transcriptional regulator HV181_15745 ENOG4108K4B hydrolase HV181_15750 ENOG4105CGB Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system (By similarity) HV181_15755 ENOG4105E0C molybdate abc transporter HV181_15760 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein HV181_15770 ENOG4105F4R Transcriptional regulator mode HV181_15775 ENOG4105DKW ABC transporter HV181_15780 ENOG4105CMR udp-glucose 4-epimerase HV181_15785 ENOG4105F0Z galactose-1-phosphate uridylyltransferase HV181_15795 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) HV181_15805 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) HV181_15810 ENOG4105JND homeobox protein HV181_15815 ENOG4105PGM cation diffusion facilitator family transporter HV181_15820 ENOG4106Z1T Nicotinamide Mononucleotide Transporter HV181_15870 ENOG4105UFD tol-pal system protein YbgF HV181_15875 ENOG4105KCK Peptidoglycan-associated lipoprotein HV181_15885 ENOG4108Z82 Cell envelope integrity inner membrane protein TolA HV181_15895 ENOG4105E02 MotA TolQ exbB proton channel HV181_15900 ENOG4107YD3 Thioesterase HV181_15905 ENOG4105KJB cyd operon protein YbgE HV181_15915 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii HV181_15920 ENOG4105C4M (Ubiquinol oxidase) subunit I HV181_15925 ENOG4105C8I hydrolase, family 38 HV181_15930 ENOG4105DM4 PTS System HV181_15935 ENOG4105FDP GntR family transcriptional regulator HV181_15940 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha HV181_15950 ENOG4105C7S Dehydrogenase HV181_15955 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 HV181_15960 ENOG4105E33 succinate dehydrogenase HV181_15965 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) HV181_15970 ENOG4105N1I succinate dehydrogenase, hydrophobic membrane anchor protein HV181_15975 ENOG4108UTY succinate dehydrogenase, cytochrome b556 subunit HV181_15985 ENOG4105BZN citrate synthase HV181_15990 ENOG4106UBK fimbrial-like adhesin protein HV181_15995 ENOG4106PG1 outer membrane usher protein HV181_16000 ENOG4108TTM chaperone HV181_16005 ENOG4108MY7 Fimbrial HV181_16010 ENOG4108KK1 membrane protein AbrB duplication HV181_16020 ENOG4105E7W lamb ycsf family protein HV181_16025 ENOG4107R7A Allophanate hydrolase subunit 2 HV181_16030 ENOG4105P4J Allophanate hydrolase, subunit 1 HV181_16035 ENOG4107QNR UPF0135 protein HV181_16040 ENOG4105DUX Transporter HV181_16045 ENOG4105CVP deoxyribo-dipyrimidine photolyase HV181_16050 ENOG4107SEY Conserved Protein HV181_16065 ENOG4106R09 HV181_16070 ENOG4105CNA YD repeat protein HV181_16075 ENOG41079JQ Membrane HV181_16080 ENOG4105CNA YD repeat protein HV181_16085 ENOG4105XIQ Protein of unknown function (DUF2517) HV181_16100 ENOG4105C8X One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) HV181_16110 ENOG4105C08 Histidine kinase HV181_16115 ENOG4105EEX Two component transcriptional regulator (Winged helix family HV181_16125 ENOG4105CXN decarboxylase HV181_16130 ENOG4105D5Q Arginine ornithine antiporter HV181_16135 ENOG4107QIX Phosphoglucomutase (EC 5.4.2.2 HV181_16140 ENOG4107CDU Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated (By similarity) HV181_16145 ENOG4105EV9 Alpha Beta Hydrolase HV181_16150 ENOG4105NNH LexA regulated protein HV181_16155 ENOG4105MHQ Low-potential electron donor to a number of redox enzymes (By similarity) HV181_16165 ENOG41090R7 Ferric uptake HV181_16170 ENOG4105GX6 (LipO)protein HV181_16185 ENOG4105CI1 PTS System HV181_16195 ENOG4105CE4 GlcNAc 6-P deacetylase HV181_16200 ENOG4105E2R ROK family HV181_16205 ENOG4105D4U had-superfamily hydrolase, subfamily iia HV181_16210 ENOG4105CAQ asparagine synthetase HV181_16250 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family HV181_16260 ENOG4105C9A Phoh family HV181_16270 ENOG4108JU5 Magnesium and cobalt efflux protein HV181_16275 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) HV181_16285 ENOG4107RP9 extracellular solute-binding protein, family 3 HV181_16290 ENOG4105EAD ABC transporter HV181_16295 ENOG4105DRP amino acid AbC transporter HV181_16300 ENOG4105CDA abc transporter atp-binding protein HV181_16310 ENOG4105F7F Chaperone HV181_16315 ENOG4105QFC Hsc56 co-chaperone of HscC HV181_16320 ENOG41069CF Protein of unknown function (DUF1266) HV181_16325 ENOG4107JFD Sel1 repeat HV181_16330 ENOG4105QFC Hsc56 co-chaperone of HscC HV181_16335 ENOG41069CF Protein of unknown function (DUF1266) HV181_16340 ENOG4105EUU Sel1 domain protein repeat-containing protein HV181_16345 ENOG4107PAI alpha helical protein HV181_16360 ENOG4105DJF DNA polymerase III, delta' subunit HV181_16370 ENOG4108TGR phosphatase HV181_16375 ENOG4105KEM Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) HV181_16385 ENOG4105CJN penicillin-binding protein HV181_16390 ENOG4105CNI cell division protein FtsW HV181_16395 ENOG4105K6T rare lipoprotein A HV181_16400 ENOG4105DZ1 carboxypeptidase HV181_16415 ENOG41064T2 transcriptional regulator, lysR family HV181_16425 ENOG410607N Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatE shares overlapping functions with TatA (By similarity) HV181_16435 ENOG4107Z6W Protein CrcB homolog HV181_16445 ENOG41079UR PagP is required both for biosynthesis of hepta-acylated lipid A species containing palmitate and for resistance to cationic antimicrobial peptides (CAMPs). It catalyzes the transfer of a palmitate chain (16 0) from the sn-1 position of a glycerophospholipid to the free hydroxyl group of the (R)-3- hydroxymyristate chain at position 2 of lipid A (endotoxin) (By similarity) HV181_16450 ENOG4105CEE C4-dicarboxylate transporter HV181_16455 ENOG4106YYS transcriptional regulatory protein HV181_16460 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism HV181_16465 ENOG4105DUA (citrate (pro-3S)-lyase ligase HV181_16475 ENOG4105CI0 Citrate lyase HV181_16480 ENOG4105CHY citrate lyase, alpha HV181_16495 ENOG4107QPK )-transporter HV181_16500 ENOG4105KTS ribonuclease HV181_16505 ENOG4105NXH GreA GreB family elongation factor HV181_16510 ENOG4105E2A Dehydrogenase HV181_16515 ENOG4108U51 Universal stress protein HV181_16520 ENOG4108JU3 Alkyl hydroperoxide reductase HV181_16525 ENOG4105D3R alkyl hydroperoxide reductase HV181_16530 ENOG4108KHN disulfide isomerase, thiol-disulfide oxidase HV181_16535 ENOG4105DQS Transcriptional regulator HV181_16540 ENOG4105BZV Phosphoadenosine phosphosulfate reductase HV181_16545 ENOG4105GTN ParB Domain Protein Nuclease HV181_16550 ENOG4105CHM Aminotransferase HV181_16555 ENOG4107SCQ Iron-containing alcohol dehydrogenase HV181_16560 ENOG4105VCD cytoplasmic protein HV181_16565 ENOG4105D22 carbon starvation protein HV181_16570 ENOG4108TZA Required for optimal enterobactin synthesis. Acts as a proofreading enzyme that prevents EntB misacylation by hydrolyzing the thioester bound existing between EntB and wrongly charged molecules (By similarity) HV181_16575 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase HV181_16580 ENOG4105WQI isochorismatase HV181_16585 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase HV181_16590 ENOG4105E4F Isochorismate synthase HV181_16595 ENOG4105PEC Iron-enterobactin transporter periplasmic binding protein HV181_16605 ENOG4105DQ5 transport system permease protein HV181_16610 ENOG4105TVJ transport system, permease HV181_16615 ENOG4105E0A ABC, transporter HV181_16620 ENOG4108QY5 Ferric enterobactin transport protein HV181_16625 ENOG4105C0W non-ribosomal peptide synthetase HV181_16630 ENOG41085A6 mbth domain-containing protein HV181_16635 ENOG4105E93 esterase HV181_16640 ENOG4107RNH Outer membrane receptor FepA HV181_16645 ENOG4108TSE Transferase HV181_16650 ENOG4107635 Hok Gef family protein HV181_16655 ENOG4106KXD ATP-dependent carboxylate-amine ligase (By similarity) HV181_16660 ENOG4105WQ6 Membrane HV181_16665 ENOG4105MSB protein, conserved in bacteria HV181_16670 ENOG4108RCM Nitroreductase HV181_16675 ENOG4105CUY Mechanosensitive ion channel HV181_16680 ENOG4105C85 amino acid HV181_16685 ENOG4108IJF Heavy metal efflux pump, CzcA HV181_16690 ENOG4105EP1 Efflux transporter rnd family, mfp subunit HV181_16695 ENOG410624V efflux system protein HV181_16700 ENOG4105ENJ RND efflux system, outer membrane lipoprotein HV181_16705 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HV181_16710 ENOG4105GR3 Histidine kinase HV181_16715 ENOG4105CS6 Rhs element vgr protein HV181_16730 ENOG4105CNA YD repeat protein HV181_16745 ENOG4105CNA YD repeat protein HV181_16760 ENOG410600T transposase HV181_16765 ENOG410802X bacteriophage n4 adsorption protein b HV181_16770 ENOG41090FC Bacteriophage N4 receptor, outer membrane subunit HV181_16775 ENOG4105QUW HV181_16790 ENOG4108Q9V regulatoR HV181_16795 ENOG4108ZI2 Fimbrial protein HV181_16800 ENOG4108M66 Involved in regulation of length and mediation of adhesion of SfmA fimbriae (but not necessary for the production of fimbriae). Seems to be mannose binding adhesin (By similarity) HV181_16810 ENOG4108AF8 Chaperone HV181_16815 ENOG4108WDE Fimbrial protein HV181_16820 ENOG4105CN0 Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity) HV181_16825 ENOG4105WQ3 Rna-binding protein HV181_16830 ENOG4105S2T inner membrane protein YbcI HV181_16840 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) HV181_16850 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) HV181_16855 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit HV181_16860 ENOG4105C5B carbamate kinase HV181_16865 ENOG4105G5A Protein of unknown function (DUF2877) HV181_16870 ENOG4107REC cytoplasmic protein HV181_16875 ENOG4107R1Q Membrane protein FdrA HV181_16880 ENOG4105DG4 malate L-lactate dehydrogenase HV181_16885 ENOG4105CE7 Amidase, hydantoinase carbamoylase family HV181_16890 ENOG4105S0E allantoin catabolism protein HV181_16895 ENOG4105BZW Glycerate kinase HV181_16900 ENOG4105DTE Xanthine uracil vitamin C permease HV181_16910 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease HV181_16915 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase HV181_16920 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) HV181_16925 ENOG41060W2 glyoxylate carboligase HV181_16930 ENOG4108N16 Negative regulator of allantoin and glyoxylate utilization operons. Binds to the gcl promoter and to the allS- allA intergenic region HV181_16940 ENOG4107653 Transcriptional regulator HV181_16950 ENOG4105CV6 ABC transporter, permease HV181_16955 ENOG4108I0Y (ABC) transporter HV181_16960 ENOG4108UJV acyl-CoA thioesterase i HV181_16965 ENOG4105E1F short-chain dehydrogenase reductase HV181_16970 ENOG4107QR8 Thioredoxin HV181_16975 ENOG4105C4B ABC transporter, permease HV181_16980 ENOG41083J0 (ABC) transporter HV181_16985 ENOG4107QX8 SPFH domain, Band 7 family protein HV181_16990 ENOG4105G5H Membrane HV181_16995 ENOG4108Z6Z Transcriptional regulator HV181_17000 ENOG4107RY6 amino acid HV181_17005 ENOG4105CSV Glutaminase HV181_17010 ENOG4105C59 p-type ATPase HV181_17015 ENOG41081XE plasmid maintenance system antidote protein, xre family HV181_17020 ENOG4105MBR gumn family HV181_17025 ENOG4108Z66 YbaK ebsC protein HV181_17030 ENOG4105CGH 5'-nucleotidase HV181_17035 ENOG4105EU0 Major facilitator Superfamily HV181_17045 ENOG4107RE1 Inosine-guanosine kinase HV181_17080 ENOG4107QMP dna polymerase iii subunits gamma and tau HV181_17090 ENOG4105WD1 Membrane HV181_17095 ENOG4108URS primosomal replication protein n'' HV181_17100 ENOG4106428 Protein of unknown function (DUF2496) HV181_17105 ENOG4105EGS Mechanosensitive ion channel HV181_17110 ENOG4107XI7 Tetr family transcriptional regulator HV181_17115 ENOG4105C1P efflux transporter, rnd family, mfp subunit HV181_17120 ENOG4105BZS acriflavin resistance protein HV181_17125 ENOG4108UKR Biofilm formation regulator YbaJ HV181_17130 ENOG4105KF5 hemolysin expression-modulating protein HV181_17135 ENOG4108UW5 maltose o-acetyltransferase HV181_17140 ENOG4105GSJ Inner membrane protein ylaC HV181_17145 ENOG41066DG (EAL) domain protein HV181_17150 ENOG4105KCV RNA signal recognition particle 4.5S RNA HV181_17160 ENOG41080UX Methyltransferase HV181_17165 ENOG4108MNP Glycoprotein polysaccharide metabolism HV181_17170 ENOG4105C29 acyl-CoA thioesterase HV181_17175 ENOG4105BZU Histidine kinase HV181_17180 ENOG4108YZA Nitrogen regulatory protein pii HV181_17185 ENOG4105BZ1 (ABC) transporter HV181_17190 ENOG4105BZ1 (ABC) transporter HV181_17195 ENOG4108XM1 transcriptional regulator AsnC family HV181_17205 ENOG4108NFA extracellular solute-binding protein HV181_17215 ENOG4108TGP Thioesterase superfamily protein HV181_17220 ENOG41083P1 competence protein ComEA helix-hairpin-helix repeat protein HV181_17225 ENOG4105EIN peptidylprolyl cis-trans isomerase HV181_17230 ENOG4105K70 DNA-binding protein HV181_17235 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) HV181_17255 ENOG4105M85 Bola protein HV181_17260 ENOG4105IEY (LipO)protein HV181_17265 ENOG4105EYM Major Facilitator superfamily HV181_17270 ENOG4105E2S oxidase) subunit II HV181_17275 ENOG4105BZ9 Cytochrome C oxidase, subunit I HV181_17280 ENOG4105CCU oxidase (Subunit III) HV181_17285 ENOG41090KH cytochrome o ubiquinol oxidase (subunit iv) HV181_17295 ENOG4107RDB Major Facilitator HV181_17305 ENOG4108JZF Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) HV181_17310 ENOG4107S0N DJ-1 family HV181_17325 ENOG4105CTB Polyprenyl synthetase HV181_17335 ENOG4105CPC Aldo Keto reductase HV181_17340 ENOG4108ZAI phosphatidylglycerophosphatase a HV181_17345 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) HV181_17355 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) HV181_17360 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) HV181_17370 ENOG4108KIC (LipO)protein HV181_17375 ENOG4105DRB nucleoside-specific channel-forming protein HV181_17380 ENOG4105N1F Hnh endonuclease HV181_17385 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) HV181_17390 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) HV181_17395 ENOG4105VIE preprotein translocase, subunit YajC HV181_17415 ENOG4107R28 alpha amylase, catalytic region HV181_17420 ENOG4105C85 amino acid HV181_17425 ENOG4105CWM branched-chain amino acid transport system II carrier protein HV181_17430 ENOG4105BZU Histidine kinase HV181_17435 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HV181_17440 ENOG4107RH8 nuclease SbcCD subunit D HV181_17445 ENOG4105EYH Exonuclease HV181_17455 ENOG4105DKQ ROK family HV181_17480 ENOG4105HBA AroM protein HV181_17485 ENOG4105SS3 HV181_17495 ENOG4108UPT UPF0178 protein HV181_17500 ENOG4105II7 pyrroline-5-carboxylate reductase HV181_17505 ENOG4105BZU Histidine kinase HV181_17510 ENOG4105VIF phosphate starvation-inducible protein HV181_17515 ENOG4105G6Z alkaline phosphatase HV181_17530 ENOG4105CPF Cell wall formation (By similarity) HV181_17535 ENOG4105UNH Membrane HV181_17540 ENOG4105FR5 inner membrane protein YaiY HV181_17545 ENOG4107QS8 (LipO)protein HV181_17550 ENOG4108DQG in Escherichia coli SbmA is involved in uptake of microcin J25 HV181_17555 ENOG4107R6D beta-lactam binding protein AmpH HV181_17560 ENOG4108PNB DNA-binding transcriptional regulator HV181_17570 ENOG4105D52 delta-aminolevulinic acid dehydratase HV181_17575 ENOG4105E2B Taurine dioxygenase HV181_17580 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component HV181_17590 ENOG4106FTQ Taurine ABC transporter, periplasmic HV181_17595 ENOG4107W19 lmbE family HV181_17600 ENOG4108PBI Polysaccharide metabolism HV181_17610 ENOG4105SRB Uncharacterized protein yaiO HV181_17630 ENOG4105IUQ nucleoprotein polynucleotide-associated enzyme HV181_17635 ENOG4108SC4 )-transporter HV181_17655 ENOG4106HB6 Alpha beta hydrolase HV181_17670 ENOG4108K2P TRANSCRIPTIONal HV181_17675 ENOG4105ETE Transcriptional regulator (LacI family HV181_17685 ENOG4105U0F oligosaccharide H symporter, major facilitator superfamily (MFS) HV181_17690 ENOG4108UW5 maltose o-acetyltransferase HV181_17695 ENOG4105DJ2 Major Facilitator Superfamily HV181_17705 ENOG4107B2H carbonic anhydrase HV181_17710 ENOG4105DND Transcriptional regulator HV181_17715 ENOG4105DZC cytosine deaminase HV181_17720 ENOG4105DQW permease for cytosine purines, uracil, thiamine, allantoin HV181_17725 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) HV181_17730 ENOG4105DXD 2-methylcitrate dehydratase HV181_17735 ENOG4105BZN citrate synthase HV181_17740 ENOG4105CR4 methylisocitrate lyase HV181_17745 ENOG4108JU7 Transcriptional regulator HV181_17750 ENOG4105TDT uncharacterized protein yahO HV181_17755 ENOG4105E82 cytochrome subunit of dehydrogenase HV181_17770 ENOG4105DQ4 alcohol dehydrogenase HV181_17775 ENOG4105DZC cytosine deaminase HV181_17780 ENOG4105C5B carbamate kinase HV181_17785 ENOG4107REC cytoplasmic protein HV181_17790 ENOG4107R1Q Membrane protein FdrA HV181_17795 ENOG4105N16 Protein of unknown function (DUF2877) HV181_17800 ENOG4107SNB ankyrin repeat protein YahD HV181_17805 ENOG4105SZ2 membrAne HV181_17815 ENOG4105BZU Histidine kinase HV181_17825 ENOG4105C94 Transporter HV181_17835 ENOG4105C26 Dehydrogenase HV181_17840 ENOG4105CZ6 Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine (By similarity) HV181_17850 ENOG4108ZZK Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source (By similarity) HV181_17855 ENOG4107QR9 Iron-sulfur cluster binding protein HV181_17860 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) HV181_17865 ENOG4108K01 transcriptional regulator HV181_17870 ENOG4107QN2 dihydrolipoyl dehydrogenase HV181_17875 ENOG41066GK UPF0379 protein ykgI HV181_17880 ENOG4108KBJ Inner membrane protein YkgB HV181_17935 ENOG4108N3D putative enzyme HV181_17940 ENOG4106PYX Receptor HV181_17945 ENOG4108UD7 cell wall organization HV181_17950 ENOG4105PI0 Ferredoxin HV181_17955 ENOG4105R3P Inner membrane protein yagU HV181_17960 ENOG4107XKX isoquinoline 1-oxidoreductase, alpha subunit HV181_17965 ENOG4105DIP Molybdopterin dehydrogenase FAD-binding HV181_17970 ENOG4105C7W Xanthine dehydrogenase HV181_17975 ENOG4107XAN XdhC and CoxI family HV181_18000 ENOG4105FCK Membrane HV181_18020 ENOG4105CIN aminoacyl-histidine dipeptidase HV181_18025 ENOG4108S2Y peptide Chain Release factor HV181_18035 ENOG4108HYG acetyltransferase HV181_18040 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) HV181_18055 ENOG4108UK5 Transposase HV181_18060 ENOG4108YS0 lipoprotein YafL HV181_18065 ENOG4105F7V ErfK ybiS ycfS ynhG family protein HV181_18070 ENOG4105E7A Glutamine amidotransferase HV181_18080 ENOG4107QPN acyl-Coa dehydrogenase HV181_18085 ENOG4108WN0 inhibitor of vertebrate lysozyme HV181_18090 ENOG4105CZ7 nitrilase cyanide hydratase and apolipoprotein n-acyltransferase HV181_18105 ENOG4105CNA YD repeat protein HV181_18110 ENOG4105CS6 Rhs element vgr protein HV181_18115 ENOG4108WC9 type VI secretion system effector, hcp1 family HV181_18170 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit HV181_18195 ENOG4105GMB type VI secretion system effector, hcp1 family HV181_18210 ENOG410600K aminopeptidase HV181_18220 ENOG4107RZZ dna polymerase iii epsilon subunit HV181_18230 ENOG4105D1A Methyltransferase HV181_18240 ENOG4105E9H Lytic Murein transglycosylase HV181_18245 ENOG4105F2W methyltransferase HV181_18255 ENOG4105HEI LysR family (Transcriptional regulator HV181_18260 ENOG4105CV8 reductase HV181_18295 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase HV181_18300 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) HV181_18305 ENOG4108UMI ABC transporter, permease HV181_18310 ENOG4105D01 (LipO)protein HV181_18315 ENOG4108R8X outer membrane lipoprotein HV181_18320 ENOG4108R96 Methyltransferase, YaeB family HV181_18330 ENOG4108UY0 (LipO)protein HV181_18335 ENOG4107EII Lipoprotein involved with copper homeostasis and adhesion HV181_18340 ENOG4108YZN class I peptide chain release factor HV181_18345 ENOG4108VWS Yaeq family HV181_18355 ENOG4105M1T rho-binding antiterminator HV181_18360 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) HV181_18365 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase HV181_18370 ENOG4105CXN decarboxylase HV181_18380 ENOG4105C0B DNA polymerase III (alpha subunit) HV181_18405 ENOG4105D7M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) HV181_18410 ENOG4108RFI Molecular chaperone that interacts specifically with outer membrane proteins, thus maintaining the solubility of early folding intermediates during passage through the periplasm (By similarity) HV181_18420 ENOG4105DZP Membrane-associated zinc metalloprotease HV181_18425 ENOG4105KNE Phosphatidate cytidylyltransferase HV181_18430 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) HV181_18435 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) HV181_18460 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) HV181_18480 ENOG4108IXP Carbohydrate diacid transcriptional activator CdaR HV181_18485 ENOG4105C0H protease HV181_18500 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) HV181_18505 ENOG4105EN6 Membrane HV181_18530 ENOG4105S6R Iron-hydroxamate transporter permease subunit HV181_18535 ENOG4105J76 Periplasmic binding protein HV181_18540 ENOG4105E0A ABC, transporter HV181_18545 ENOG4105E0K tonB-dependent siderophore receptor HV181_18550 ENOG4105BZ4 penicillin-binding protein HV181_18555 ENOG4105CQ7 ATP-dependent helicase HV181_18560 ENOG4107XID 2'-5' rna ligase HV181_18580 ENOG4105DJ0 Poly(A) Polymerase HV181_18585 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase HV181_18595 ENOG4108VEV chaperone HV181_18600 ENOG4105CW0 outer membrane usher protein HV181_18605 ENOG4108XEY fimbrial-like adhesin protein HV181_18610 ENOG4105SYG Fimbrial protein HV181_18615 ENOG4105SN2 fimbrial-like adhesin protein HV181_18620 ENOG4105P0Q fimbrial-like protein YadC HV181_18635 ENOG4108A32 Transposase HV181_18645 ENOG4107BJW polysaccharide deacetylase HV181_18650 ENOG4108YTN IIa component HV181_18655 ENOG4105E3A (ABC) transporter HV181_18660 ENOG4105DA5 (ABC) transporter HV181_18665 ENOG41077A9 carbonic anhydrase HV181_18670 ENOG4108UGV hypoxanthine phosphoribosyltransferase HV181_18675 ENOG4105DZG Dehydrogenase HV181_18680 ENOG4105E3B Multicopper oxidase HV181_18685 ENOG4108ZRK uncharacterized protein yacC HV181_18705 ENOG4107QIJ Aconitate hydratase 2 HV181_18710 ENOG4108NST exported protein HV181_18715 ENOG4107QN2 dihydrolipoyl dehydrogenase HV181_18720 ENOG4107QSN dihydrolipoamide acetyltransferase HV181_18725 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) HV181_18730 ENOG41073TP transcriptional regulator HV181_18735 ENOG4105C85 amino acid HV181_18740 ENOG4106A72 regulatory protein AmpE HV181_18745 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase HV181_18750 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase HV181_18755 ENOG4108ZUW Major pilin subunit HV181_18760 ENOG4107QHF type ii secretion system protein e HV181_18765 ENOG4105D7Q type ii secretion system HV181_18780 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) HV181_18795 ENOG4105M6F mutator MutT protein HV181_18805 ENOG4108SR7 Regulates secA expression by translational coupling of the secM secA operon. Translational pausing at a specific Pro residue 5 residues before the end of the protein may allow disruption of a mRNA repressor helix that normally suppresses secA translation initiation (By similarity) HV181_18815 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) HV181_18820 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) HV181_18825 ENOG4105K7E Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity) HV181_18830 ENOG4105CPF Cell wall formation (By similarity) HV181_18835 ENOG4105DFU Cell wall formation (By similarity) HV181_18845 ENOG4105CNI cell division protein FtsW HV181_18850 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) HV181_18860 ENOG4108EQQ Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity) HV181_18865 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) HV181_18870 ENOG4105CJN penicillin-binding protein HV181_18875 ENOG41063Y6 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) HV181_18890 ENOG4107B7Y DNA-binding transcriptional regulator FruR HV181_18900 ENOG4108ZP8 Acetolactate synthase small subunit HV181_18905 ENOG4105C7K acetolactate synthase HV181_18915 ENOG41064T2 transcriptional regulator, lysR family HV181_18930 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) HV181_18945 ENOG4105S8Q sugar efflux transporter HV181_18960 ENOG4105DP9 ABC transporter HV181_18965 ENOG4106SMU thiamine transporter membrane protein HV181_18975 ENOG4108KF1 Membrane HV181_18980 ENOG41063TF transcriptional regulator (AraC HV181_18985 ENOG4105EF1 ribulokinase HV181_18995 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase HV181_19000 ENOG4105CQ2 DNA polymerase HV181_19005 ENOG4105BZK Transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA. Does not activate transcription on linear DNA. Probably not involved in DNA repair (By similarity) HV181_19010 ENOG4105D3G Pseudouridine synthase HV181_19015 ENOG41066UG Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host (By similarity) HV181_19020 ENOG4105E7H involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity) HV181_19025 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) HV181_19045 ENOG4105DDT Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity) HV181_19050 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) HV181_19065 ENOG4105C54 Major Facilitator superfamily HV181_19070 ENOG4105IBM Could be part of an electron transfer system required for anaerobic carnitine reduction. Could be a 3Fe-4S cluster- containing protein HV181_19075 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase HV181_19080 ENOG4105C10 Electron transfer flavoprotein HV181_19110 ENOG4106YT9 Enoyl-CoA hydratase HV181_19120 ENOG4108XNW Transcriptional activatory protein CaiF HV181_19125 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain HV181_19130 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain HV181_19150 ENOG41090X3 Peptidyl-prolyl cis-trans isomerase HV181_19160 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) HV181_19165 ENOG4105DTN riboflavin biosynthesis protein ribF HV181_19170 ENOG410647N response to DNA damage stimulus HV181_19185 ENOG4105CW0 outer membrane usher protein HV181_19200 ENOG41063Z6 transcriptional regulator, lysR family HV181_19210 ENOG4105WI6 cell killing protein encoded within cryptic prophage HV181_19230 ENOG4108QUJ UPF0174 protein YaaW HV181_19235 ENOG4106HK8 GPR1 FUN34 yaaH family protein HV181_19240 ENOG4108RIR Molybdenum cofactor biosynthesis protein HV181_19245 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) HV181_19250 ENOG4105BZG amino acid carrier protein HV181_19260 ENOG41062C6 Protein of unknown function (DUF2502) HV181_19265 ENOG4105D98 threonine synthase HV181_19275 ENOG4105CFH Aspartokinase HV181_19285 ENOG4106FVC RNA methyltransferase HV181_19290 ENOG410759A HV181_19295 ENOG41065U4 response regulator HV181_19300 ENOG4105CT7 inner membrane cred family protein HV181_19305 ENOG4105EB3 Histidine kinase HV181_19310 ENOG4105E3W Two component transcriptional regulator (Winged helix family HV181_19315 ENOG4108RH0 Crea protein HV181_19320 ENOG4105UEI Transcriptional Regulator AraC Family HV181_19330 ENOG4108K16 Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) HV181_19340 ENOG4107SC1 transglycosylase HV181_19345 ENOG4105C5H ABC transporter HV181_19355 ENOG4107VZS Nicotinamide-nucleotide adenylyltransferase HV181_19360 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) HV181_19365 ENOG4105EAC phosphoserine phosphatase HV181_19370 ENOG41062Z9 Membrane HV181_19405 ENOG4105G0K glycine radical enzyme YjjI family HV181_19410 ENOG41076CZ activating enzyme HV181_19415 ENOG4105EYA deoxyribonuclease HV181_19420 ENOG4108NRW Phospholipase, patatin family HV181_19430 ENOG4105K3G Periplasmic Protein HV181_19440 ENOG4105PAD Hydrolase HV181_19445 ENOG4105KEG ribosomal-protein-alanine acetyltransferase HV181_19450 ENOG4108WPU DNA polymerase III subunit psi HV181_19455 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) HV181_19475 ENOG4105YBH Protein of unknown function (DUF1435) HV181_19480 ENOG4108819 ferric iron reductase HV181_19485 ENOG4108T94 DNA-binding transcriptional activator BglJ HV181_19490 ENOG4108N8T regulatoR HV181_19495 ENOG4105DWK Membrane HV181_19500 ENOG4107XM3 UPF0442 protein HV181_19510 ENOG4106CVF DNA replication protein HV181_19515 ENOG4105RI1 glycoprotein receptor HV181_19525 ENOG4105CPQ Dehydrogenase HV181_19535 ENOG4108I5G Major Facilitator superfamily HV181_19540 ENOG4105C8Q Methyl-accepting chemotaxis HV181_19545 ENOG4108V8F Transcriptional regulator, MarR family HV181_19550 ENOG4105ERH Fumarylacetoacetate hydrolase HV181_19555 ENOG4105C26 Dehydrogenase HV181_19560 ENOG4107THI 3,4-dihydroxyphenylacetate 2,3-dioxygenase HV181_19590 ENOG4105EFA 4-hydroxyphenylacetate HV181_19595 ENOG4107UWN reductase HV181_19600 ENOG4105D22 carbon starvation protein HV181_19605 ENOG4105VCD cytoplasmic protein HV181_19610 ENOG4105CKI cobalamin synthesis protein HV181_19615 ENOG4106H3A restriction HV181_19620 ENOG4107SCJ type I restriction enzyme EcoKI subunit R HV181_19625 ENOG4105CVR type I restriction-modification system HV181_19640 ENOG4105FBQ ATPase associated with various cellular activities aaa_5 HV181_19645 ENOG4107SQC 5-methylcytosine-specific restriction enzyme subunit McrC HV181_19655 ENOG4108YUH HV181_19665 ENOG4108YUH HV181_19670 ENOG4106DIZ Domain of unknown function (DUF1127) HV181_19675 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HV181_19685 ENOG41083G8 Multidrug resistance protein MdtM HV181_19690 ENOG4106BRA Membrane HV181_19695 ENOG4105DCU 2-hydroxyglutaryl-CoA dehydratase HV181_19700 ENOG4105CIZ coA-substrate-specific enzyme activase HV181_19710 ENOG4108ZK4 sdia-regulated domain-containing protein HV181_19715 ENOG4105CBP Major Facilitator HV181_19725 ENOG41074DU domain protein HV181_19730 ENOG4108P2H Inner membrane protein YjiG HV181_19735 ENOG4105DYB Isoaspartyl dipeptidase HV181_19740 ENOG4107YNJ LysR family Transcriptional regulator HV181_19760 ENOG4105C6F GntR Family Transcriptional Regulator HV181_19765 ENOG4105DEI Mannitol dehydrogenase HV181_19775 ENOG4107EFN gluconate transport system permease 3 HV181_19780 ENOG410643X FIMH SUBUNIT MANNOSE-sensitive type 1 fimbrial adhesin HV181_19785 ENOG4108T65 Fimbrial HV181_19790 ENOG4108SQA Fimbrial HV181_19795 ENOG4105CW0 outer membrane usher protein HV181_19800 ENOG4108NAE Fimbrial chaperone protein HV181_19805 ENOG4108S54 Fimbrial protein HV181_19810 ENOG4108RQP Major type 1 subunit fimbrin HV181_19815 ENOG4105E71 FimE is one of the 2 regulatory proteins which control the phase variation of type 1 fimbriae in E.coli. These proteins mediate the periodic inversion of a 300bp DNA segment that harbors the promoter for the fimbrial structural gene, fimA. FimE switches fimA off HV181_19820 ENOG4108W9T type 1 fimbriae regulatory protein HV181_19825 ENOG41069FU Outer membrane channel protein allowing the entry of N- acetylneuraminic acid (Neu5Ac, the most abundant sialic acid on host cell surfaces) into the bacteria HV181_19830 ENOG4108MX5 Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses (By similarity) HV181_19850 ENOG4105YCT UPF0386 protein HV181_19855 ENOG41080VW acetyltransferase HV181_19860 ENOG4105DTA methyltransferase HV181_19870 ENOG4105CN9 Peptidase m42 family protein HV181_19875 ENOG4105K18 The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane (By similarity) HV181_19880 ENOG4105DT3 PTS system, galactitol-specific IIc component HV181_19885 ENOG4106P19 photosystem i assembly btpa HV181_19890 ENOG4108XBJ The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane (By similarity) HV181_19895 ENOG4108RK0 3-epimerase HV181_19900 ENOG4108PQ7 sgc region transcriptional regulator HV181_19905 ENOG4106P37 HTH-type transcriptional regulator YjhI HV181_19910 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) HV181_19915 ENOG4105C01 Dihydroxy-acid dehydratase HV181_19920 ENOG4105C6Z Gluconate HV181_19925 ENOG4105DKT Transcriptional regulator HV181_19935 ENOG4107W7X Aldolase HV181_19945 ENOG4105CT5 Catalyzes the phosphorylation of methylthioribose into methylthioribose-1-phosphate (By similarity) HV181_19955 ENOG4105MAW Antitoxin component of a toxin-antitoxin (TA) module. Labile antitoxin that counteracts the effect of the CbtA (YeeV) toxin. It does not bind to the cognate toxin but instead binds to MreB and FtsZ (the toxin targets), enhancing their polymerization by forming higher-order bundles HV181_19965 ENOG4108YGG dna repair protein HV181_19970 ENOG4105MFG Antirestriction protein HV181_19975 ENOG4106H6R UPF0380 protein HV181_19985 ENOG4105F4K antigen 43 HV181_19995 ENOG4108P8R HV181_20035 ENOG4108YXQ IS66 Orf2 family protein HV181_20040 ENOG4105E5H Transposase HV181_20075 ENOG4108SF5 RNA Polymerase HV181_20080 ENOG4108S3W Anti-feci sigma factor, fecr HV181_20085 ENOG4105GAV receptor HV181_20090 ENOG4108HUF Transporter HV181_20095 ENOG4105DQ5 transport system permease protein HV181_20100 ENOG4108IHU transport system permease protein HV181_20105 ENOG4105E0A ABC, transporter HV181_20120 ENOG4105EKQ RNA-directed DNA polymerase HV181_20145 ENOG4107RJ5 oxidoreductase HV181_20150 ENOG4105JHE Major Facilitator Superfamily HV181_20155 ENOG4105VNT transposase (IS4 family) protein HV181_20185 ENOG4105DQ4 alcohol dehydrogenase HV181_20190 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family HV181_20195 ENOG4105CPQ Dehydrogenase HV181_20200 ENOG4105CHR reductase HV181_20205 ENOG4105C6Z Gluconate HV181_20210 ENOG4105K2J Transcriptional regulator HV181_20215 ENOG4105D7A ATP-binding protein HV181_20220 ENOG4108K5H permease YjgP YjgQ family protein HV181_20225 ENOG4108M8S permease YjgP YjgQ family protein HV181_20235 ENOG4105MYG DNA polymerase iii, chi subunit HV181_20240 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) HV181_20245 ENOG4108M3P Membrane HV181_20250 ENOG4108MJ3 acetyltransferase HV181_20255 ENOG4105KQT Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome (By similarity) HV181_20260 ENOG4105DBV ornithine carbamoyltransferase HV181_20270 ENOG4105XEP YhcH YjgK YiaL family protein HV181_20275 ENOG4108XFH Transcriptional regulator HV181_20280 ENOG4105F6U Short-chain dehydrogenase reductase Sdr HV181_20285 ENOG4108UQ8 endoribonuclease L-psp HV181_20290 ENOG4107C93 pyrBI operon leader peptide HV181_20305 ENOG4105KME endoribonuclease L-psp HV181_20310 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic HV181_20320 ENOG4105D4X repressor HV181_20325 ENOG4105C5Y PTS System HV181_20330 ENOG4105CG3 alpha amylase, catalytic region HV181_20335 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase HV181_20340 ENOG4108RDD Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine (By similarity) HV181_20350 ENOG4105CMS peptidase U62, modulator of DNA gyrase HV181_20360 ENOG4105DFU Cell wall formation (By similarity) HV181_20370 ENOG41062B0 ABC transporter, permease HV181_20375 ENOG4107R9N ABC transporter HV181_20380 ENOG4105C2J ABC transporter HV181_20385 ENOG4107R5U Periplasmic binding protein LacI transcriptional regulator HV181_20390 ENOG4105F0N pyrophosphate phospho-hydrolase HV181_20395 ENOG4105MZG transcriptional modulator of maze toxin, mazf HV181_20400 ENOG41087RY SpoVT_AbrB HV181_20405 ENOG4108ZHD aig2 family HV181_20410 ENOG4105MA0 exported protein HV181_20415 ENOG4105CFU surface antigen HV181_20425 ENOG4105C37 (CBS) domain HV181_20430 ENOG41061GZ Protein of unknown function (DUF1107) HV181_20435 ENOG4108UUE Transcriptional regulator HV181_20440 ENOG4108RNI 3'(2')5'-bisphosphate nucleotidase HV181_20445 ENOG4107RNS bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase 3'-nucleotidase periplasmic HV181_20450 ENOG4105KVH Transcriptional regulator HV181_20455 ENOG4105ECR NmrA family HV181_20460 ENOG4105DXC membrane HV181_20480 ENOG4105C85 amino acid HV181_20485 ENOG4108V1T peptidylprolyl cis-trans isomerase HV181_20490 ENOG4105FHY Opacity-associated protein A HV181_20500 ENOG4105CHR reductase HV181_20510 ENOG4105E39 Enoyl-CoA hydratase HV181_20515 ENOG4107R0K CoA transferase having broad substrate specificity for short-chain acyl-CoA thioesters with the activity decreasing when the length of the carboxylic acid chain exceeds four carbons (By similarity) HV181_20520 ENOG4107S3R L-aspartate oxidase HV181_20525 ENOG41069H7 transport system small permease component HV181_20530 ENOG4105CG6 trap dicarboxylate transporter dctm subunit HV181_20535 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit HV181_20545 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) HV181_20560 ENOG4105KIT UPF0379 protein yjfY HV181_20585 ENOG410907W The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in ascorbate transport HV181_20590 ENOG4105CZC PTS system ascorbate-specific transporter subunit IIC HV181_20605 ENOG4108MXZ Esterase HV181_20610 ENOG4105WSB biofilm stress and motility protein A HV181_20615 ENOG4105S17 UPF0379 protein yjfN HV181_20620 ENOG4105CSU acyl-Coa dehydrogenase HV181_20625 ENOG4106032 Glutathionylspermidine synthase HV181_20630 ENOG4108KXT Conserved Protein HV181_20635 ENOG4105Z6B inner membrane protein yjfl HV181_20640 ENOG4107VNS Protein of unknown function (DUF2491) HV181_20645 ENOG4108P9J Phage shock protein A HV181_20650 ENOG4105FUX Conserved Protein HV181_20655 ENOG4105C2N RNA methyltransferase TrmH family group 3 HV181_20660 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) HV181_20680 ENOG4105EPW hflc protein HV181_20685 ENOG4107QJR hflk protein HV181_20690 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) HV181_20705 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) HV181_20710 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase HV181_20715 ENOG4105K8N protein family UPF0079, ATPase HV181_20720 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) HV181_20725 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) HV181_20765 ENOG4105EGS Mechanosensitive ion channel HV181_20770 ENOG4107SC7 Inner membrane transporter yjeM HV181_20775 ENOG4105CAP With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P (By similarity) HV181_20780 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) HV181_20785 ENOG4105E33 succinate dehydrogenase HV181_20800 ENOG41066YJ Beta-lactamase HV181_20805 ENOG4105QNF Outer membrane lipoprotein HV181_20810 ENOG4105KPY Small multidrug resistance protein HV181_20815 ENOG4106BSU Entericidin B HV181_20820 ENOG4107PEH Entericidin EcnA/B family HV181_20830 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein HV181_20835 ENOG4105MTB Uncharacterized protein YjeJ HV181_20840 ENOG4108ZVF (LipO)protein HV181_20855 ENOG4105DVH amino acid HV181_20860 ENOG4108YH1 overproduction of this protein in Escherichia coli inhibits the F plasmid-mediated exclusion of bacteriophage T7 HV181_20865 ENOG4108IJ0 Aspartate ammonia-lyase HV181_20870 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter HV181_20885 ENOG4108SIC Transcriptional regulator HV181_20895 ENOG4108M3R transcriptional activator CadC HV181_20900 ENOG4105D5Q Arginine ornithine antiporter HV181_20905 ENOG4105CXN decarboxylase HV181_20910 ENOG4105DUX Transporter HV181_20915 ENOG4105CRK lysyL-tRNA synthetase HV181_20930 ENOG410830R acetyltransferase HV181_20935 ENOG4105VR1 Pfam:DUF1271 HV181_20940 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism HV181_20945 ENOG4108MRH transcriptional regulatory protein HV181_20950 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter HV181_20955 ENOG4107GFK fumarate HV181_20960 ENOG4108R5S membrane HV181_20965 ENOG4105CT4 transporter HV181_20970 ENOG4105F8D glycoside hydrolase family 4 HV181_20975 ENOG4108K2B transcriptional regulator HV181_20980 ENOG4105CXN decarboxylase HV181_20985 ENOG4106ZGR Transcriptional regulator HV181_20990 ENOG4105D5Q Arginine ornithine antiporter HV181_20995 ENOG4105DIJ Phosphoethanolamine transferase HV181_21000 ENOG4105XJC Two component transcriptional regulator (Winged helix family HV181_21005 ENOG4105ECM Sensor protein basS pmrB HV181_21015 ENOG4105CSH Transporter HV181_21020 ENOG4108YIV HV181_21025 ENOG4108F5E vimentin HV181_21030 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA HV181_21035 ENOG4108SQ4 Glyoxalase Bleomycin resistance protein (Dioxygenase HV181_21040 ENOG4105D5T phosphonate abc transporter HV181_21045 ENOG4105EHI Phosphonate ABC transporter, periplasmic HV181_21055 ENOG4107RJJ Transcriptional regulator HV181_21060 ENOG4105KQZ Phosphonate C-P lyase system protein PhnG HV181_21065 ENOG4105KZ6 phosphonate C-P lyase system protein PhnH HV181_21070 ENOG4105EKV Phosphonate metabolism protein HV181_21075 ENOG4105FT8 Phosphonate metabolism HV181_21080 ENOG4105ENV phosphonate C-P lyase system protein PhnK HV181_21085 ENOG4105HRV phosphonate c-p lyase system protein phnl HV181_21090 ENOG4105FD8 phosphonate metabolism protein PhnM HV181_21095 ENOG4105MFQ Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP) (By similarity) HV181_21100 ENOG410849A acetyltransferase, (GNAT) family HV181_21105 ENOG4107SA6 carbon-phosphorus lyase complex accessory protein HV181_21115 ENOG4108YZG isomerase HV181_21120 ENOG4105NYY transcriptional regulator, RpiR HV181_21125 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator HV181_21130 ENOG4105C2J ABC transporter HV181_21135 ENOG4105CNN ABC, transporter HV181_21140 ENOG4105UP7 3-epimerase HV181_21145 ENOG4107TFG D-allose kinase HV181_21150 ENOG4105EUZ Beta-lactamase domain protein HV181_21160 ENOG4105J12 Multidrug resistance protein mdtN HV181_21165 ENOG4108MI0 Resistance protein HV181_21170 ENOG4105ETP RND efflux system, outer membrane lipoprotein HV181_21180 ENOG41082ND Uncharacterized protein yjcO HV181_21185 ENOG4105CK2 sodium dicarboxylate symporter HV181_21190 ENOG4108W0S formate-dependent nitrite reductase complex HV181_21200 ENOG4108QKW cytochrome c-type biogenesis protein HV181_21205 ENOG4105DVI reductase, NrfD HV181_21210 ENOG4105D3S 4Fe-4S Ferredoxin, iron-sulfur binding domain protein HV181_21215 ENOG4105JJ8 Cytochrome c nitrite reductase, pentaheme subunit HV181_21225 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) HV181_21230 ENOG41062QD Membrane HV181_21245 ENOG4105EEQ Na H antiporter HV181_21250 ENOG4105C7N Xanthine uracil vitamin C permease HV181_21255 ENOG4108Z4X TRANSCRIPTIONal HV181_21260 ENOG4108W3Q Transcriptional regulator HV181_21265 ENOG4108M8H domain protein HV181_21270 ENOG4105PMV Membrane HV181_21275 ENOG4108UUM single-stranded DNA-binding protein HV181_21280 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) HV181_21285 ENOG4105MSB protein, conserved in bacteria HV181_21290 ENOG4108YXI Secondary thiamine-phosphate synthase enzyme HV181_21295 ENOG4105F0S class B acid phosphatase HV181_21305 ENOG4105CGF Aromatic amino acid aminotransferase HV181_21310 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) HV181_21315 ENOG4105CDU Replicative dna helicase HV181_21320 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein HV181_21325 ENOG4105P4Z Phage shock protein G HV181_21330 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) HV181_21340 ENOG4105MYN Zinc uptake regulation protein HV181_21345 ENOG4105VDW Csbd family HV181_21350 ENOG4107R73 Mate efflux family protein HV181_21360 ENOG41080IJ Diacylglycerol kinase HV181_21385 ENOG4107W52 maltose operon periplasmic protein HV181_21395 ENOG4108IJ9 (ABC) transporter HV181_21400 ENOG4107FKK extracellular solute-binding protein family 1 HV181_21405 ENOG4105D56 permease protein HV181_21410 ENOG4105EG2 ABC transporter, permease HV181_21415 ENOG4107QNK )-transporter HV181_21435 ENOG4105E3R (LipO)protein HV181_21440 ENOG4108Q9C Periplasmic Protein HV181_21445 ENOG4108MDC (LipO)protein HV181_21455 ENOG4107QP8 phosphohexose isomerase HV181_21460 ENOG4105CFH Aspartokinase HV181_21465 ENOG4108WZA zeta toxin HV181_21470 ENOG410756H nucleotidyltransferase HV181_21480 ENOG4108ZR5 Conserved Protein HV181_21485 ENOG4105FE9 pseudouridine synthase HV181_21490 ENOG4105DKT Transcriptional regulator HV181_21495 ENOG4105CHR reductase HV181_21500 ENOG4108XCU pts system HV181_21505 ENOG4105KPI PTS system sorbose subfamily IIB component HV181_21510 ENOG4105ETZ PTS System HV181_21515 ENOG4105F3R pts system mannose fructose sorbose family iid HV181_21520 ENOG4105DXH Alcohol dehydrogenase zinc-binding domain protein HV181_21530 ENOG4105EAM Na Pi-cotransporter HV181_21535 ENOG4105C3R Methionine synthase HV181_21540 ENOG41069M3 Transcriptional regulator HV181_21555 ENOG4108I9X Isocitrate lyase HV181_21560 ENOG4107QP3 malate synthase g HV181_21570 ENOG4105K5X acetyltransferase HV181_21575 ENOG41062WK cellular response to acidity HV181_21600 ENOG4105DC1 bifunctional purine biosynthesis protein purh HV181_21605 ENOG4105C12 Phosphoribosylglycinamide synthetase HV181_21610 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family HV181_21615 ENOG4105BZU Histidine kinase HV181_21620 ENOG4105JBU Binds zinc. Could be an important component of the zinc- balancing mechanism HV181_21625 ENOG4108T8B Protein of unknown function (DUF1481) HV181_21635 ENOG4105R2J Conserved Protein HV181_21670 ENOG4105D06 uba thif-type nad fad binding protein HV181_21675 ENOG4105WHD thiamine biosynthesis protein ThiS HV181_21685 ENOG4105D41 biosynthesis protein thiH HV181_21690 ENOG410645W Thiamin biosynthesis protein ThiH HV181_21725 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) HV181_21730 ENOG4105PM1 preprotein translocase subunit SecE HV181_21765 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase HV181_21810 ENOG4108Y73 Membrane HV181_21815 ENOG4105EJ2 Transcriptional regulator HV181_21825 ENOG4105C5Q Transcriptional regulator HV181_21830 ENOG4108I5G Major Facilitator superfamily HV181_21835 ENOG4105CXK mandelate racemase muconate lactonizing HV181_21850 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase HV181_21865 ENOG4105DIJ Phosphoethanolamine transferase HV181_21870 ENOG4106R3P AraC family transcriptional regulator HV181_21875 ENOG4108XCZ PTS System HV181_21880 ENOG4108AHH pyruvate formate lyase II activase HV181_21890 ENOG4108YRF PTS System HV181_21895 ENOG4105DM4 PTS System HV181_21900 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) HV181_21905 ENOG4107T9Z Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) HV181_21910 ENOG4105DCT glycerol dehydrogenase HV181_21915 ENOG4108XC3 NADH ubiquinone oxidoreductase HV181_21920 ENOG4108Q5Y Membrane HV181_21930 ENOG4105SYT Methylenetetrahydrofolate reductase HV181_21935 ENOG4105CFH Aspartokinase HV181_21940 ENOG4105C28 cystathionine HV181_21950 ENOG4107S01 Repressor protein MetJ HV181_21965 ENOG4105CNA YD repeat protein HV181_21975 ENOG4105C25 Primosomal protein n' HV181_21980 ENOG4105ETE Transcriptional regulator (LacI family HV181_21985 ENOG41063M6 Cell Division Protein HV181_22000 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase HV181_22015 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) HV181_22025 ENOG4105CBT Fructose-1,6-bisphosphatase HV181_22030 ENOG4105DP0 ferredoxin-NADP reductase HV181_22040 ENOG41065TG regulatoR HV181_22045 ENOG4108VTS Membrane HV181_22050 ENOG4105EBK exported protein HV181_22065 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein HV181_22080 ENOG4105FMW periplasmic HV181_22085 ENOG4105E3W Two component transcriptional regulator (Winged helix family HV181_22090 ENOG4105E0F Histidine kinase HV181_22095 ENOG4108RPX mosc domain containing protein HV181_22105 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) HV181_22135 ENOG4105C9J Catalyzes the reversible cleavage of L-rhamnulose-1- phosphate to dihydroxyacetone phosphate (DHAP) and L-lactaldehyde (By similarity) HV181_22145 ENOG41064BA PTS system, fructose-specific, IIA component HV181_22150 ENOG4105DM4 PTS System HV181_22155 ENOG4105CN9 Peptidase m42 family protein HV181_22160 ENOG4106C3V frv operon regulatory protein HV181_22165 ENOG4108V87 frv operon regulatory protein HV181_22170 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) HV181_22180 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein HV181_22185 ENOG4108MG3 formate dehydrogenase HV181_22195 ENOG41068KX affects formate dehydrogenase-N HV181_22205 ENOG4105SUU thioesterase domain HV181_22220 ENOG4105EJU HAD-superfamily hydrolase subfamily IA variant 3 HV181_22225 ENOG4105E98 transcriptional regulator DeoR family HV181_22230 ENOG4108MGF sugar kinase HV181_22235 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase HV181_22240 ENOG4105D2M Aldolase HV181_22245 ENOG4107QKS N-acylglucosamine 2-epimerase HV181_22250 ENOG4107WI4 Aldose-1-epimerase HV181_22255 ENOG4105CJQ hydrolase, family 31 HV181_22260 ENOG4105CT4 transporter HV181_22265 ENOG4105CT4 transporter HV181_22270 ENOG4108KUC Outer membrane channel protein that allows an efficient diffusion of low-molecular-weight solutes such as small sugars and tetraglycine. However, the specific substrate recognized by the OmpL channel is HV181_22275 ENOG4105R9B Major Facilitator HV181_22280 ENOG4108KHF Resistance protein HV181_22285 ENOG4108K85 Transcriptional regulator HV181_22290 ENOG4105CI3 gtp-binding protein typa HV181_22295 ENOG4105C5F glutamine synthetase HV181_22300 ENOG4105CUX Signal transduction histidine kinase HV181_22305 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family HV181_22310 ENOG4106FIY HV181_22315 ENOG4105D4P Coproporphyrinogen iii oxidase HV181_22330 ENOG4105C2M dna polymerase I HV181_22335 ENOG4106HNH Acyl-transferase HV181_22345 ENOG4108Z33 Thiol disulfide Interchange Protein HV181_22350 ENOG4105E27 serine threonine protein kinase HV181_22355 ENOG4105PC1 Conserved Protein HV181_22360 ENOG4105C6R Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) HV181_22365 ENOG4105FNP Molybdopterin-guanine dinucleotide biosynthesis protein b HV181_22395 ENOG4108RR8 protoporphyrinogen oxidase HV181_22400 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) HV181_22405 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein HV181_22415 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase HV181_22425 ENOG4108EX3 reductase HV181_22430 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) HV181_22435 ENOG4105MDZ Transcriptional activator rfaH HV181_22440 ENOG4105F8V Hydrolase, tatD family HV181_22445 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) HV181_22450 ENOG4105X8U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity) HV181_22455 ENOG4105WKS Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) HV181_22465 ENOG4105JC1 sterol-binding domain protein HV181_22475 ENOG4105CGY Dna recombination protein HV181_22480 ENOG4108I5U Uridine phosphorylase HV181_22485 ENOG4105CDZ Carboxymethylenebutenolidase (EC 3.1.1.45) HV181_22495 ENOG4105DZ2 Transcriptional regulator HV181_22500 ENOG4105EMK carboxylate amino acid amine transporter HV181_22505 ENOG4105DQF Hydrolase HV181_22510 ENOG4108EUD Lysophospholipase HV181_22515 ENOG410829K Lysine exporter protein (Lyse ygga) HV181_22520 ENOG4105CCF Lysine exporter protein (Lyse ygga) HV181_22525 ENOG4105C9U ATP-dependent DNA helicase RecQ HV181_22530 ENOG4105HDD phospholipase HV181_22535 ENOG4108VUY thioesterase Superfamily protein HV181_22540 ENOG4105FR1 rard protein HV181_22545 ENOG4106WR8 Inner membrane protein YigG HV181_22550 ENOG4105NRM Membrane HV181_22555 ENOG4107QUT magnesium and cobalt transport protein CorA HV181_22560 ENOG4108T58 Mg2 transport protein CorA HV181_22565 ENOG4105C4R Atp-dependent dna helicase HV181_22570 ENOG4105DFC had-superfamily hydrolase, subfamily ia, variant HV181_22580 ENOG4105CT0 Protein of unknown function, DUF484 HV181_22590 ENOG4105S7Z (LipO)protein HV181_22600 ENOG4107T0K Adenylate cyclase HV181_22605 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) HV181_22610 ENOG41076E6 Uroporphyrinogen-III Synthase HV181_22615 ENOG4105ECF c-methyltransferase HV181_22620 ENOG410601J HemY protein HV181_22625 ENOG4105ENH Sulfatase HV181_22630 ENOG4105C4X radical SAM domain protein HV181_22655 ENOG4105C85 amino acid HV181_22670 ENOG4105F18 Catalyzes the synthesis of Und-PP-GlcNAc-ManNAcA-Fuc4NAc (Lipid III), the third lipid-linked intermediate involved in ECA synthesis (By similarity) HV181_22675 ENOG4105EGZ biosynthesis protein HV181_22680 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase HV181_22685 ENOG4108WJ1 acetyltransferase HV181_22690 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) HV181_22695 ENOG4105C1B dTDP-glucose 4-6-dehydratase HV181_22700 ENOG4107QQG Dehydrogenase HV181_22705 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase HV181_22710 ENOG4105SFE lipopolysaccharide biosynthesis protein HV181_22715 ENOG4105ESV Glycosyl transferase, family 4 HV181_22720 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) HV181_22745 ENOG4105C4R Atp-dependent dna helicase HV181_22755 ENOG4105KQ5 peptidylprolyl cis-trans isomerase HV181_22765 ENOG4105EMY transcriptional regulator HV181_22770 ENOG4105C7B Threonine dehydratase HV181_22780 ENOG4105CM2 brancheD-chain amino acid aminotransferase HV181_22785 ENOG4105P3Y Acetolactate synthase 2 regulatory subunit HV181_22805 ENOG4105C0P Mg chelatase subunit ChlI HV181_22810 ENOG4108WFC UPF0438 protein yifE HV181_22850 ENOG4107EJG GntR family transcriptional regulator HV181_22855 ENOG4105C0R drug resistance transporter emrb qaca subfamily HV181_22860 ENOG4105ETE Transcriptional regulator (LacI family HV181_22865 ENOG4108RVA ribokinase HV181_22870 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator HV181_22875 ENOG4105CNN ABC, transporter HV181_22900 ENOG4105EV2 VWA domain protein interacting with AAA ATPase HV181_22910 ENOG4108VVK transcriptional Regulator, AsnC HV181_22915 ENOG4105QTB Flavodoxin HV181_22930 ENOG4105GXX Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit I associates with the membrane and may be involved with cation translocation HV181_22980 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) HV181_22985 ENOG4108RQP Major type 1 subunit fimbrin HV181_22995 ENOG4105CW0 outer membrane usher protein HV181_23005 ENOG4107QMV Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity) HV181_23010 ENOG4105C8U phosphate abc transporter HV181_23015 ENOG4105E2Z phosphate ABC transporter (Permease HV181_23020 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) HV181_23025 ENOG4108UTW Plays a role in the regulation of phosphate uptake HV181_23030 ENOG4105CID antiterminator HV181_23035 ENOG4105C5Y PTS System HV181_23040 ENOG4105CS2 ec 3.2.1.21 HV181_23050 ENOG4105DYC esterase HV181_23055 ENOG4107VKM 6-phosphogluconolactonase HV181_23060 ENOG4106611 bacteriocin immunity HV181_23070 ENOG4107UB3 HAD-superfamily hydrolase subfamily IA variant 3 HV181_23075 ENOG4105C7N Xanthine uracil vitamin C permease HV181_23080 ENOG4108YYH Nadph-dependent fmn reductase HV181_23085 ENOG4105E8Q phosphopantetheinyl transferase HV181_23095 ENOG4105CNH Multidrug resistance protein MdtL HV181_23100 ENOG4108P6C Tryptophan transporter of low affinity HV181_23115 ENOG4105C1H Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity) HV181_23135 ENOG4105VG0 50S ribosomal protein l34 HV181_23160 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HV181_23165 ENOG4107QK5 Homocysteine s-methyltransferase HV181_23170 ENOG4108IQI permease HV181_23185 ENOG4108ZZK Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source (By similarity) HV181_23190 ENOG4107QR9 Iron-sulfur cluster binding protein HV181_23195 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) HV181_23200 ENOG4105CXG d-lactate dehydrogenase