locus-tag class description G4278_00010 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) G4278_00020 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) G4278_00025 ENOG4105VP5 Bacterial protein of unknown function (DUF937) G4278_00030 ENOG410667J hydrolase G4278_00035 ENOG410657R replicase EC 2.7 G4278_00040 ENOG4105EMF GntR family transcriptional regulator G4278_00045 ENOG4105EI3 2-dehydro-3-deoxygalactonokinase EC 2.7.1.58 G4278_00050 ENOG4108RTU Aldolase G4278_00060 ENOG4105DJB Major Facilitator Superfamily G4278_00065 ENOG4107WAP fad NAD(P)-binding domain G4278_00070 ENOG4105D99 atp gtp-binding protein G4278_00075 ENOG4105R2A (LipO)protein G4278_00095 ENOG4108AHD Transcriptional regulator G4278_00100 ENOG4107RUZ Sss sodium solute transporter superfamily G4278_00105 ENOG4105CBG Sulfatase G4278_00110 ENOG4105VG5 Membrane G4278_00115 ENOG4105JP4 Inner membrane protein yidG G4278_00120 ENOG4105J13 transcriptional regulator G4278_00125 ENOG4105E5M Multidrug resistance protein D G4278_00135 ENOG4105C7K acetolactate synthase G4278_00140 ENOG4105M71 acetolactate synthase 1 regulatory subunit G4278_00150 ENOG4108KX4 response regulator G4278_00155 ENOG4105BZU Histidine kinase G4278_00160 ENOG4105CXY transporter G4278_00165 ENOG4105CXY transporter G4278_00170 ENOG4105CPN adenine deaminase G4278_00175 ENOG4105C7N Xanthine uracil vitamin C permease G4278_00180 ENOG4108SAJ Protein of unknown function (DUF1198) G4278_00185 ENOG4107RTG Major Facilitator superfamily G4278_00190 ENOG4105T8A Uncharacterized protein YicS G4278_00195 ENOG4105D01 (LipO)protein G4278_00200 ENOG4108UZ3 Transporter G4278_00230 ENOG4108X3P Toxic component of a toxin-antitoxin (TA) module. Overexpression results in inhibition of growth in liquid cultures G4278_00235 ENOG4105MAW Antitoxin component of a toxin-antitoxin (TA) module. Labile antitoxin that counteracts the effect of the CbtA (YeeV) toxin. It does not bind to the cognate toxin but instead binds to MreB and FtsZ (the toxin targets), enhancing their polymerization by forming higher-order bundles G4278_00240 ENOG4108XS9 dna repair protein G4278_00270 ENOG4108MXD gtp-binding protein G4278_00275 ENOG4108KZE transcriptional regulator G4278_00305 ENOG4105DFP Integrase G4278_00315 ENOG4105CT4 transporter G4278_00320 ENOG4105CJQ hydrolase, family 31 G4278_00325 ENOG4105ETD TRANSCRIPTIONal G4278_00330 ENOG4105DM4 PTS System G4278_00335 ENOG4108YRF PTS System G4278_00340 ENOG4105DM4 PTS System G4278_00345 ENOG4105D2N Aldolase G4278_00350 ENOG4105D2N Aldolase G4278_00355 ENOG4105DKQ ROK family G4278_00365 ENOG4105JV1 AsmA family G4278_00370 ENOG4105C2W permease G4278_00375 ENOG4105D6U Sodium Glutamate Symporter G4278_00380 ENOG4105CB5 ATP-dependent DNA helicase recG G4278_00385 ENOG4105FE8 tRNA (Guanosine-2'-O-)-methyltransferase G4278_00390 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) G4278_00400 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) G4278_00405 ENOG410649J Catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction (By similarity) G4278_00410 ENOG4105EN6 Membrane G4278_00415 ENOG4105F5P DNA-damage-inducible protein d G4278_00420 ENOG4105DSJ YicC domain protein G4278_00440 ENOG4108Z1K This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) G4278_00445 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase G4278_00455 ENOG4105KDC 50s ribosomal protein l28 G4278_00465 ENOG4105ERD Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates (By similarity) G4278_00475 ENOG4105D8A 3-Deoxy-D-manno-octulosonic-acid transferase G4278_00480 ENOG4105DKP glycosyl transferase, family 9 G4278_00485 ENOG4107RJ7 Glycosyl transferase (Group 1 G4278_00490 ENOG4107543 (lipo)polysaccharide G4278_00495 ENOG4106AH0 Glycosyl Transferase G4278_00500 ENOG4105X1N Glycosyl transferase family 8 G4278_00510 ENOG4105X1N Glycosyl transferase family 8 G4278_00515 ENOG4105K64 Glycosyl transferase, family 2 G4278_00520 ENOG41068PG O-Antigen polymerase G4278_00525 ENOG4105D16 lipopolysaccharide heptosyltransferase i G4278_00530 ENOG4105XA0 heptosyltransferase ii G4278_00540 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) G4278_00550 ENOG4105K64 Glycosyl transferase, family 2 G4278_00555 ENOG4105PXI polysaccharide deacetylase G4278_00560 ENOG41063SB peptidase G4278_00570 ENOG4107YZP Rhodanese domain protein G4278_00575 ENOG4105VW4 glutaredoxin 3 G4278_00590 ENOG4105D7W serine acetyltransferase G4278_00595 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) G4278_00605 ENOG41073TP transcriptional regulator G4278_00610 ENOG4105DAA L-lactate G4278_00620 ENOG4108WY4 inner membrane lipoprotein G4278_00625 ENOG4108YYI Protein of unknown function (DUF2810) G4278_00630 ENOG41060ND LF82 chromosome, complete sequence G4278_00635 ENOG4105E61 Mannitol repressor protein G4278_00645 ENOG4105CTS PTS system mannitol-specific G4278_00650 ENOG4105FP6 Protein of unknown function (DUF3302) G4278_00655 ENOG4105EFX secretion protein, HlyD family G4278_00660 ENOG4108U78 Glutathione S-transferase G4278_00670 ENOG4105EM7 Selenocysteine-specific translation elongation factor G4278_00675 ENOG4105C0A alcohol dehydrogenase G4278_00685 ENOG4105C26 Dehydrogenase G4278_00690 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase G4278_00695 ENOG41064BZ L-xylulose 5-phosphate 3-epimerase G4278_00700 ENOG4105H6Q decarboxylase G4278_00705 ENOG4105CMG Carbohydrate kinase G4278_00710 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit G4278_00715 ENOG4105CG6 trap dicarboxylate transporter dctm subunit G4278_00720 ENOG4105XDZ Tripartite ATP-independent periplasmic transporter G4278_00725 ENOG4108M5W G4278_00730 ENOG4108R66 Conserved Protein G4278_00740 ENOG4105J4Q Transcriptional regulator G4278_00745 ENOG4108XIB electron transport protein ysaA G4278_00750 ENOG4105JKW Valine--pyruvate aminotransferase G4278_00755 ENOG4107T9C Alpha amylase catalytic region G4278_00760 ENOG4108UR8 BAX protein G4278_00765 ENOG4105T16 Transcriptional regulator (AraC family) G4278_00770 ENOG4108HWW ABC transporter G4278_00775 ENOG4105C2J ABC transporter G4278_00780 ENOG4105DFW ABC transporter G4278_00790 ENOG4105CMG Carbohydrate kinase G4278_00795 ENOG410688U Inner membrane protein yiaB G4278_00800 ENOG4108Z12 YiaAB two helix domain-containing protein G4278_00805 ENOG4105MEV Acyl-transferase G4278_00825 ENOG41060TC Hok gef cell toxic protein G4278_00835 ENOG4105MVF Transcriptional regulator G4278_00840 ENOG4106JH6 (LipO)protein G4278_00845 ENOG4105C5I Dehydrogenase G4278_00850 ENOG4108ZG0 Ompa motb domain protein G4278_00855 ENOG4107QY8 reductase G4278_00860 ENOG4105HNP -acetyltransferase G4278_00865 ENOG4108R3E Dna-3-methyladenine glycosylase i G4278_00870 ENOG4105EAX Putative lipase G4278_00875 ENOG4105FCD Major Facilitator G4278_00880 ENOG4105DIJ Phosphoethanolamine transferase G4278_00890 ENOG4105DEF Extracellular solute-binding protein, family 5 G4278_00900 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component G4278_00905 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component G4278_00910 ENOG4105C3U ABC transporter G4278_00915 ENOG4108JQ7 (ABC) transporter G4278_00920 ENOG4105C44 Serine transporter G4278_00935 ENOG4105D1V cellulose synthase operon protein YhjU G4278_00940 ENOG4105WQA Cellulose biosynthesis protein BcsF G4278_00945 ENOG4105U74 cellulose biosynthesis protein BcsE G4278_00950 ENOG410661M cytoplasmic protein G4278_00960 ENOG4107QZ7 Cellulose synthase catalytic subunit G4278_00965 ENOG4107EEX Cellulose synthase regulator protein G4278_00970 ENOG4105K2Z endo-1,4-d-glucanase (EC 3.2.1.4) G4278_00975 ENOG4105EJG cellulose synthase G4278_00980 ENOG4105BZU Histidine kinase G4278_00990 ENOG4105CS0 peptidase G4278_00995 ENOG4107SS6 2-dehydro-3-deoxygluconokinase G4278_01000 ENOG4105CMB EAL domain-containing protein G4278_01005 ENOG41066T0 asmA family G4278_01010 ENOG4105CSH Transporter G4278_01015 ENOG4107H3J ribonuclease G4278_01020 ENOG4105CBN LysR family transcriptional regulator G4278_01025 ENOG4106S2D Transcriptional regulator G4278_01035 ENOG4105CA0 peroxidase G4278_01040 ENOG4105CVK Glutamate decarboxylase G4278_01045 ENOG4108NKV transcriptional regulator G4278_01050 ENOG4105D3F AraC Family Transcriptional Regulator G4278_01055 ENOG4105BZS acriflavin resistance protein G4278_01060 ENOG4105C1P efflux transporter, rnd family, mfp subunit G4278_01070 ENOG4106WJ0 Regulates the expression of several genes involved in acid resistance. Required for the expression of gadA and gadBC, among others, regardless of media or growth conditions. Binds directly to the 20 bp GAD box found in the control regions of both loci G4278_01075 ENOG4108YK4 Acid-resistance membrane protein G4278_01080 ENOG41060V2 Acid-resistance protein G4278_01085 ENOG4105XXV Acid-resistance protein G4278_01090 ENOG4105KT7 mgtC SapB transporter G4278_01095 ENOG4108IPX Part of the ABC transporter complex HmuTUV involved in hemin import. Responsible for energy coupling to the transport system (By similarity) G4278_01100 ENOG4105EHG Permease protein G4278_01110 ENOG41090JE Utilization Protein G4278_01115 ENOG4105D4P Coproporphyrinogen iii oxidase G4278_01125 ENOG4107ENK receptor G4278_01130 ENOG4106QJH hemin transport protein G4278_01140 ENOG4105Y4Z Outer Membrane Lipoprotein G4278_01150 ENOG4105K89 arsenate reductase G4278_01160 ENOG4105DC8 reductase G4278_01165 ENOG4105D6S protein involved in catabolism of external DNA G4278_01170 ENOG4105DGW oligopeptidase A G4278_01180 ENOG4105DUX Transporter G4278_01195 ENOG4105CJ3 phosphate transporter G4278_01200 ENOG4105CBX hi0933 family G4278_01205 ENOG4107UNS conserved inner membrane protein G4278_01210 ENOG4105D0S secretion protein (HlyD G4278_01215 ENOG4105CJ1 ABC, transporter G4278_01220 ENOG4105CMI transporter G4278_01225 ENOG4105D2N Aldolase G4278_01240 ENOG4105DT3 PTS system, galactitol-specific IIc component G4278_01245 ENOG41090UW PTS System G4278_01265 ENOG4105EFJ Part of the ABC transporter complex NikABCDE involved in nickel import. Responsible for energy coupling to the transport system (By similarity) G4278_01270 ENOG4106665 Part of the ABC transporter complex NikABCDE involved in nickel import. Responsible for energy coupling to the transport system (By similarity) G4278_01275 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component G4278_01280 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component G4278_01285 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein G4278_01290 ENOG4107YAK holo-(acyl carrier protein) synthase 2 G4278_01295 ENOG4105DSF transport protein G4278_01300 ENOG4105F9N Major Facilitator Superfamily G4278_01305 ENOG4108W1V Lipoprotein G4278_01310 ENOG4105EX9 Membrane G4278_01325 ENOG4107FS9 Membrane G4278_01335 ENOG4105MG3 Membrane G4278_01340 ENOG4106H78 methyltransferase G4278_01345 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) G4278_01350 ENOG4105CAK Cell division ATP-binding protein ftsE G4278_01355 ENOG4105CRP Part of the ABC transporter FtsEX involved in G4278_01360 ENOG4105DEK Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) G4278_01365 ENOG4105CP9 extracellular ligand-binding receptor G4278_01370 ENOG4105U59 -acetyltransferase G4278_01375 ENOG4105CP9 extracellular ligand-binding receptor G4278_01380 ENOG4105C32 Amino acid ABC transporter (Permease) G4278_01385 ENOG4105CF8 branched-chain amino acid ABC transporter, permease G4278_01390 ENOG4105C0Z ABC transporter G4278_01395 ENOG4108IV0 ABC, transporter G4278_01400 ENOG4105BZ7 extracellular solute-binding protein family 1 G4278_01405 ENOG4105E4X binding-protein-dependent transport systems inner membrane Component G4278_01415 ENOG4108IJ9 (ABC) transporter G4278_01420 ENOG4107T6V glycerophosphoryl diester phosphodiesterase G4278_01425 ENOG4105WC8 Conserved Protein G4278_01430 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) G4278_01435 ENOG4106FA4 G4278_01450 ENOG4105GMB type VI secretion system effector, hcp1 family G4278_01460 ENOG4105D9R oxidoreductase G4278_01465 ENOG4105C2I pirin domain protein G4278_01470 ENOG4105DIQ Transcriptional regulator G4278_01475 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family G4278_01480 ENOG4105C6Z Gluconate G4278_01485 ENOG4105C9U ATP-dependent DNA helicase RecQ G4278_01495 ENOG41076UM multiple antibiotic resistance (MarC)-related protein G4278_01500 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) G4278_01505 ENOG4105C9C Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position (By similarity) G4278_01510 ENOG4108IUM Glycogen debranching enzyme G4278_01525 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) G4278_01535 ENOG4108NAE Fimbrial chaperone protein G4278_01540 ENOG4105CW0 outer membrane usher protein G4278_01550 ENOG4108RQP Major type 1 subunit fimbrin G4278_01555 ENOG4108AF8 Chaperone G4278_01560 ENOG4105MHR Fimbrial protein G4278_01580 ENOG4105C6V Glycerol-3-phosphate dehydrogenase G4278_01595 ENOG4105E98 transcriptional regulator DeoR family G4278_01600 ENOG4105CYB regulatoR G4278_01605 ENOG4105E0Y RtcB Protein G4278_01615 ENOG41061ZR Transcriptional regulator G4278_01620 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) G4278_01625 ENOG4107RTM 4-alpha-glucanotransferase (EC 2.4.1.25) G4278_01630 ENOG4105C6Z Gluconate G4278_01640 ENOG4105MJ2 Competence protein G4278_01645 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) G4278_01660 ENOG4105CE1 Ferrous iron transport protein b G4278_01665 ENOG4105XFK Ferrous iron transport protein A G4278_01670 ENOG4105BZM domain protein G4278_01675 ENOG4108RRZ Transcription elongation factor GreB G4278_01685 ENOG4105E0F Histidine kinase G4278_01700 ENOG4105DJ1 Phosphoenolpyruvate Carboxylase G4278_01705 ENOG4108MAJ Membrane G4278_01715 ENOG4105VEJ Heat shock protein G4278_01720 ENOG4107Y3D HAD-superfamily hydrolase subfamily IA variant 3 G4278_01725 ENOG4105DQY intracellular growth attenuator G4278_01730 ENOG4107RK2 ADP-ribose diphosphatase NudE G4278_01735 ENOG4108JQC penicillin-binding protein 1A G4278_01740 ENOG4108U1Q Pilus assembly protein G4278_01745 ENOG41065NF Fimbrial assembly family protein G4278_01750 ENOG4105XPX DNA utilization protein HofO G4278_01755 ENOG4105ITY Required for the use of extracellular DNA as a nutrient G4278_01760 ENOG4105E4G Type IV pilus G4278_01775 ENOG4105EGB membrane protein DamX G4278_01780 ENOG4105DFE Dna adenine methylase G4278_01785 ENOG4105DJV ribulose-phosphate 3-epimerase G4278_01790 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) G4278_01795 ENOG4105C31 Tryptophanyl-tRNA synthetase G4278_01800 ENOG4108M21 G4278_01805 ENOG4105RMW regulation of transcription, DNA-dependent G4278_01810 ENOG4108626 Racemase G4278_01815 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) G4278_01820 ENOG41080QX K07048 phosphotriesterase-related protein G4278_01825 ENOG4105MUZ Protein of unknown function DUF2620 G4278_01830 ENOG4106M0N transport system permease protein G4278_01835 ENOG4106PKC pyridoxal phosphate binding G4278_01840 ENOG4105VYH G4278_01850 ENOG4107V9H nitrite transporter G4278_01855 ENOG4105WZK nitrite reductase NADPH small subunit G4278_01860 ENOG4107QZF nitrite reductase NADPH large subunit G4278_01870 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) G4278_01880 ENOG4105MZU cell filamentation protein G4278_01885 ENOG4105DDQ anthranilate synthase G4278_01890 ENOG4105C8Y Acetylornithine aminotransferase G4278_01895 ENOG410613R integral membrane protein, YccS YhfK family G4278_01905 ENOG4108UKZ OsmC family G4278_01910 ENOG4105CJE phosphoribulokinase (EC 2.7.1.19) G4278_01920 ENOG4105DNZ Alpha Beta Hydrolase G4278_01925 ENOG4105C5H ABC transporter G4278_01940 ENOG4105VKU nucleicacid-binding protein G4278_01945 ENOG4108YZY peptidylprolyl cis-trans isomerase G4278_01955 ENOG4108V1T peptidylprolyl cis-trans isomerase G4278_01960 ENOG4105WWK YheO domain protein G4278_02000 ENOG4108NNZ chitinase G4278_02005 ENOG4105W53 bacterioferritin-associated ferredoxin G4278_02010 ENOG4108UQY Iron-storage protein G4278_02015 ENOG4105EHH Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue (By similarity) G4278_02025 ENOG41063JA Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins (By similarity) G4278_02045 ENOG41069X0 general secretion pathway protein h G4278_02050 ENOG4108VAU general secretion pathway protein G G4278_02055 ENOG4105D7Q type ii secretion system G4278_02060 ENOG4107QHF type ii secretion system protein e G4278_02065 ENOG4105GVR general secretion pathway protein D G4278_02070 ENOG4107KSE General secretion pathway protein C G4278_02075 ENOG410899B May play a regulatory role under conditions of derepressed gsp gene expression G4278_02080 ENOG4107ACA Calcium-binding protein required for initiation of chromosome replication G4278_02100 ENOG41080KG One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) G4278_02190 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) G4278_02195 ENOG41067V7 50S ribosomal protein L36 G4278_02225 ENOG4105VTS DnaJ-like, subfamily C G4278_02230 ENOG4105W1Y Transcriptional regulator G4278_02235 ENOG4105VCN Rescues the ribosomes stalled at the 3' end of non-stop mRNAs. May induce hydrolysis of the ribosome-bound peptidyl-tRNA. This activity is crucial when the stalled ribosome can not be rescued by the SsrA(tmRNA)-SmpB quality control system G4278_02245 ENOG4105C1A potassium transporter peripheral membrane G4278_02250 ENOG4105CYJ ribosomal RNA small subunit methyltransferase B G4278_02255 ENOG4105CAE Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity) G4278_02265 ENOG4105C79 DNA protecting protein DprA G4278_02275 ENOG4108WI1 Dna topoisomerase G4278_02280 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) G4278_02285 ENOG4105E2X shikimate dehydrogenase G4278_02290 ENOG4105SG3 Protein of unknown function (DUF1488) G4278_02295 ENOG4108Z0R Transferase G4278_02335 ENOG4105CDA abc transporter atp-binding protein G4278_02340 ENOG4105DRP amino acid AbC transporter G4278_02345 ENOG4105EZ7 amino acid ABC transporter G4278_02355 ENOG4105XCM membrane LIPOPROTEIN G4278_02360 ENOG4105BZS acriflavin resistance protein G4278_02365 ENOG4105C1P efflux transporter, rnd family, mfp subunit G4278_02370 ENOG4108XG4 DNA-binding transcriptional regulator G4278_02375 ENOG41061ME transport protein G4278_02380 ENOG4105CEC DNA methylase N-4 N-6 G4278_02390 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) G4278_02400 ENOG4108IA2 Sodium pantothenate symporter G4278_02405 ENOG4105RG0 Membrane G4278_02410 ENOG4107UEK pfkb domain protein G4278_02415 ENOG4105E98 transcriptional regulator DeoR family G4278_02420 ENOG4105D2N Aldolase G4278_02425 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator G4278_02430 ENOG4105C2J ABC transporter G4278_02435 ENOG4105CNN ABC, transporter G4278_02440 ENOG4107UEK pfkb domain protein G4278_02450 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase G4278_02455 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein G4278_02465 ENOG4105D3Z quinone oxidoreductase, yhdh yhfp family G4278_02470 ENOG41062P1 Diguanylate cyclase phosphodiesterase G4278_02480 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) G4278_02485 ENOG4105VQ7 Rod shape-determining protein MreD G4278_02490 ENOG4108Z03 MAF-like protein G4278_02495 ENOG4105C03 ribonuclease G4278_02500 ENOG4105QD6 exported protein G4278_02505 ENOG4105D1U peptidase U62 modulator of DNA gyrase G4278_02510 ENOG4105CR8 Transcriptional regulator G4278_02515 ENOG4105ZQC membrane protein AaeX G4278_02525 ENOG4107Z11 Efflux pump whose substrates are p-hydroxybenzoic acid (pHBA), 6-hydroxy-2-naphthoic and 2-hydroxycinnamate. Could function as a metabolic relief valve, allowing to eliminate certain compounds when they accumulate to high levels in the cell (By similarity) G4278_02530 ENOG4105UNR (Barnase) inhibitor G4278_02535 ENOG4105RID UPF0379 protein yhcN G4278_02550 ENOG4105C0H protease G4278_02555 ENOG4105C0H protease G4278_02560 ENOG4108W2Q Cytochrome d ubiquinol oxidase subunit III G4278_02565 ENOG4105D6Z AFG1 family ATPase G4278_02580 ENOG4107MKT Stringent starvation protein a G4278_02585 ENOG4105KB2 stringent starvation protein b G4278_02600 ENOG4105JHE Major Facilitator Superfamily G4278_02610 ENOG41061DF Catalyzes the phosphorylation of N-acetylmannosamine (ManNAc) to ManNAc-6-P (By similarity) G4278_02615 ENOG4108R66 Conserved Protein G4278_02620 ENOG4105BZ8 glutamate synthase G4278_02625 ENOG4105CBC glutamate synthase G4278_02630 ENOG4105N5T Radical SAM Protein G4278_02635 ENOG4105BZU Histidine kinase G4278_02640 ENOG4108556 Isoprenoid biosynthesis protein with amidotransferase-like domain G4278_02650 ENOG4108NIH transferase activity, transferring phosphorus-containing groups G4278_02655 ENOG41080Z8 PHOSPHOCARRIER protein G4278_02665 ENOG4107RM2 PTS IIA-like nitrogen-regulatory protein PtsN G4278_02670 ENOG41080QH sigma 54 modulation protein ribosomal protein S30EA G4278_02675 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) G4278_02680 ENOG4108IUZ ABC transporter G4278_02685 ENOG4105WI0 lipopolysaccharide transport periplasmic protein lptA G4278_02690 ENOG4108P1K Required for the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane (By similarity) G4278_02700 ENOG4105C2X Arabinose 5-phosphate isomerase G4278_02705 ENOG4105FEU K -dependent Na -Ca exchanger G4278_02710 ENOG4105DHJ ABC, transporter G4278_02715 ENOG4105CY3 ABC transporter, permease G4278_02720 ENOG4107PE3 Mammalian cell entry related domain protein G4278_02725 ENOG4105E3I toluene tolerance G4278_02730 ENOG4105UE2 Part of the ABC transporter complex MlaFEDB that actively prevents phospholipid accumulation at the cell surface. Probably maintains lipid asymmetry in the outer membrane by retrograde trafficking of phospholipids from the outer membrane to the inner membrane G4278_02735 ENOG4105VFK BolA family G4278_02745 ENOG4105HVQ Regulatory factor of maltose metabolism G4278_02750 ENOG4105EAH synthase G4278_02765 ENOG4105QYV Membrane G4278_02775 ENOG4106HRJ d-alanyl-d-alanine carboxypeptidase G4278_02780 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) G4278_02785 ENOG4105HBR Rna-binding protein G4278_02795 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) G4278_02800 ENOG4105EEI dihydropteroate synthase G4278_02810 ENOG4105NTZ Preprotein translocase subunit SecG G4278_02820 ENOG4105DIJ Phosphoethanolamine transferase G4278_02840 ENOG4105CHV Transcription elongation factor NusA G4278_02880 ENOG4105C1J atp-dependent rna helicase G4278_02885 ENOG4105CIC tryptophan-specific transport protein G4278_02890 ENOG4105DEN Luciferase family G4278_02910 ENOG4108YYD acetyltransferase G4278_02925 ENOG4105K4T epimerase G4278_02930 ENOG4107S21 permease G4278_02935 ENOG4105W4M Transport-associated protein G4278_02950 ENOG4105E1C Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1A (PBP1a) (By similarity) G4278_02955 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) G4278_02960 ENOG4106HBN Galactosamine-6-phosphate isomerase G4278_02965 ENOG4105F3R pts system mannose fructose sorbose family iid G4278_02970 ENOG4105ETZ PTS System G4278_02975 ENOG4108UZY PTS System G4278_02985 ENOG4105E70 isomerase G4278_02990 ENOG4105CE4 GlcNAc 6-P deacetylase G4278_02995 ENOG4108YTN IIa component G4278_03000 ENOG4105F3R pts system mannose fructose sorbose family iid G4278_03010 ENOG4108RG5 PTS system N-acetylgalactosamine-specific transporter subunit IIB G4278_03020 ENOG4105E98 transcriptional regulator DeoR family G4278_03025 ENOG4108R8Z these effects are overcome by concomitant expression of antitoxin SohA (PrlF). Massive overexpression is toxic. Unlike most other characterized TA systems degrades rRNA, and co-folding of the proteins is necessary in vitro for inhibition of the RNase activity. It is not known if it has any sequence-specificity. Acts as a transcription factor. The YhaV PrlF complex binds the prlF-yhaV operon, probably negatively regulating its expression G4278_03030 ENOG4105ZEG Suppressor protein G4278_03035 ENOG4105CTX dehydratase G4278_03040 ENOG4105DJB Major Facilitator Superfamily G4278_03045 ENOG4105CNV Aldolase G4278_03050 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase G4278_03055 ENOG4105BZW Glycerate kinase G4278_03070 ENOG410811B TRANSCRIPTIONal G4278_03075 ENOG4105C7B Threonine dehydratase G4278_03090 ENOG4105C6N Formate acetyltransferase G4278_03095 ENOG4105KME endoribonuclease L-psp G4278_03100 ENOG4105EJQ L-serine dehydratase G4278_03105 ENOG4105C44 Serine transporter G4278_03115 ENOG4106D80 Uncharacterized protein YhaL G4278_03120 ENOG4108CNN domain protein G4278_03125 ENOG4105CWB LysR family transcriptional Regulator G4278_03130 ENOG4105KAF membrAne G4278_03135 ENOG4105CHF Glutathione S-transferase G4278_03140 ENOG4108VBZ doxx family G4278_03145 ENOG4105YJD G4278_03150 ENOG41090KG Inner membrane protein YqjE G4278_03155 ENOG4105NE1 Conserved Protein G4278_03160 ENOG4105WAY exported protein G4278_03165 ENOG4105IYR Modulates the activity of the EnvZ OmpR two-component regulatory system, probably by directly modulating EnvZ enzymatic activity and increasing stability of phosphorylated OmpR (By similarity) G4278_03170 ENOG4106W5V Membrane G4278_03175 ENOG4107YCY Transcriptional regulator G4278_03180 ENOG4105DPW Major facilitator superfamily MFS_1 G4278_03190 ENOG4105CTX dehydratase G4278_03195 ENOG4105P66 Membrane G4278_03200 ENOG4107QV7 Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system) (By similarity) G4278_03205 ENOG4105DU1 integral membrane protein, terc G4278_03210 ENOG4105EE0 oxidoreductase G4278_03215 ENOG4108UB4 uncharacterized protein ygjQ G4278_03220 ENOG4108VKG metal-dependent hydrolase G4278_03235 ENOG4108Z3N Transcriptional regulator G4278_03240 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase G4278_03245 ENOG4107WCA isomerase G4278_03250 ENOG4107W6W Conserved Protein G4278_03255 ENOG4105E5D amino acid G4278_03260 ENOG4105FK9 beta-D-galactosidase beta subunit G4278_03265 ENOG4105CNT hydrolase family 2 G4278_03270 ENOG4105CQ4 Transcriptional regulator G4278_03275 ENOG4108Y51 tRNA-binding protein G4278_03280 ENOG4105C8Y Acetylornithine aminotransferase G4278_03285 ENOG4107RHT methyl-accepting chemotaxis sensory transducer with Pas Pac sensor G4278_03290 ENOG4105NTW Transcriptional regulator G4278_03295 ENOG4105Q26 Siderophore-interacting protein G4278_03310 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) G4278_03315 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) G4278_03335 ENOG4107GFK fumarate G4278_03355 ENOG4107ZVW dihydroneopterin aldolase G4278_03365 ENOG4105D4J Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate G4278_03370 ENOG4106MWK domain protein G4278_03375 ENOG4105D7V transposase G4278_03385 ENOG4105I7R Adenylate cyclase G4278_03390 ENOG4105CE6 Adenylation and deadenylation of glutamate--ammonia ligase (By similarity) G4278_03405 ENOG4107S78 Band 7 protein G4278_03410 ENOG4105PV3 Inner membrane protein yqiJ G4278_03420 ENOG4105W0Z cytoplasmic protein G4278_03430 ENOG4108MY7 Fimbrial G4278_03435 ENOG4108TTM chaperone G4278_03445 ENOG4105H8W Fimbrial protein G4278_03460 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b G4278_03470 ENOG4108N92 Thiol disulfide Interchange Protein G4278_03475 ENOG4108MR7 Arylsulfotransferase G4278_03480 ENOG4106032 Glutathionylspermidine synthase G4278_03490 ENOG4105DFG type I secretion outer membrane protein G4278_03495 ENOG41087AY ADP-Ribose pyrophosphatase G4278_03500 ENOG4108SX3 cytoplasmic protein G4278_03505 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) G4278_03510 ENOG4105IPS esterase G4278_03515 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) G4278_03525 ENOG4105E0A ABC, transporter G4278_03530 ENOG4105DQ5 transport system permease protein G4278_03535 ENOG4105EHG Permease protein G4278_03545 ENOG4106KNT transcriptional regulator G4278_03550 ENOG4105VRH Antibiotic biosynthesis monooxygenase G4278_03555 ENOG4105NF4 modulator of drug activity G4278_03565 ENOG4107DEU Inner membrane protein YgiZ G4278_03570 ENOG4105DHQ Histidine kinase G4278_03575 ENOG4105XJC Two component transcriptional regulator (Winged helix family G4278_03580 ENOG4105H4F exported protein G4278_03585 ENOG4105F4I Transcriptional regulator G4278_03590 ENOG4108J59 Extracellular solute-binding protein, family 5 G4278_03595 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) G4278_03600 ENOG4107S7E 1-acyl-sn-glycerol-3-phosphate acyltransferase G4278_03605 ENOG4107TZ2 Cell division protein that is required for growth during stress conditions. May be involved in protecting or stabilizing the divisomal assembly under conditions of stress (By similarity) G4278_03610 ENOG4105CG6 trap dicarboxylate transporter dctm subunit G4278_03620 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit G4278_03625 ENOG4105DG4 malate L-lactate dehydrogenase G4278_03630 ENOG4105CPQ Dehydrogenase G4278_03635 ENOG4105DEI Mannitol dehydrogenase G4278_03640 ENOG4107YCY Transcriptional regulator G4278_03645 ENOG4105CCT upf0313 protein G4278_03655 ENOG4105ZKC Conserved Protein G4278_03660 ENOG4105CV8 reductase G4278_03665 ENOG4108I6A alcohol dehydrogenase G4278_03670 ENOG4105CF7 AraC family transcriptional regulator G4278_03675 ENOG4108K81 inner membrane protein YghB G4278_03680 ENOG4105C28 cystathionine G4278_03685 ENOG4105CWK Biopolymer transport protein, ExbB G4278_03690 ENOG4108ZZF transport protein (ExbD) G4278_03695 ENOG4105CYX Short-chain dehydrogenase reductase Sdr G4278_03705 ENOG4105CPC Aldo Keto reductase G4278_03715 ENOG410900S Protein of unknown function (DUF2623) G4278_03720 ENOG4105E3S small subunit G4278_03725 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein G4278_03730 ENOG4105CJ5 hydrogenase 2 b cytochrome subunit G4278_03735 ENOG4105DPX Hydrogenase, large subunit G4278_03740 ENOG4108USZ hydrogenase G4278_03745 ENOG4108WGS hydrogenase 2-specific chaperone G4278_03750 ENOG4105WMM Probably plays a role in a hydrogenase nickel cofactor insertion step (By similarity) G4278_03755 ENOG41082MF Hydrogenase assembly chaperone hypC hupF G4278_03760 ENOG4105CYM Glutathione S-transferase G4278_03765 ENOG4106032 Glutathionylspermidine synthase G4278_03770 ENOG4105CJ3 phosphate transporter G4278_03775 ENOG4108GH0 ATP-binding protein yghT G4278_03780 ENOG4108NDC ATP-binding protein yghS G4278_03785 ENOG4106FPV ATP-binding protein YghR G4278_03790 ENOG4108S55 polysaccharide biosynthesis protein G4278_03800 ENOG4108UUE Transcriptional regulator G4278_03805 ENOG4108M8S permease YjgP YjgQ family protein G4278_03815 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) G4278_03820 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) G4278_03830 ENOG4107RCI amp-dependent synthetase and ligase G4278_03840 ENOG4108KWP DNA-binding transcriptional regulator GlcC G4278_03845 ENOG4105CQB FAD linked oxidase domain protein G4278_03850 ENOG4105EU8 FAD linked oxidase domain protein G4278_03855 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) G4278_03860 ENOG4108ZJF Glcg protein G4278_03865 ENOG4107QP3 malate synthase g G4278_03870 ENOG4105DAA L-lactate G4278_03875 ENOG4105F88 accessory colonization factor AcfD G4278_03885 ENOG410765S (LipO)protein G4278_03900 ENOG4107QHF type ii secretion system protein e G4278_03905 ENOG4105D7Q type ii secretion system G4278_03910 ENOG4108VAU general secretion pathway protein G G4278_03920 ENOG4105X5Z General secretion pathway protein I G4278_03940 ENOG4105U1E general secretion pathway protein M G4278_03945 ENOG41090SZ ABC-2 type transporter G4278_03975 ENOG4105K64 Glycosyl transferase, family 2 G4278_03985 ENOG41084CK capsule polysaccharide G4278_03990 ENOG4105E12 capsule polysaccharide G4278_03995 ENOG4105CET Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity) G4278_04000 ENOG4107V1M polysaccharide export protein G4278_04005 ENOG4105ECX polysaccharide export G4278_04010 ENOG4105C2X Arabinose 5-phosphate isomerase G4278_04050 ENOG4105MAW Antitoxin component of a toxin-antitoxin (TA) module. Labile antitoxin that counteracts the effect of the CbtA (YeeV) toxin. It does not bind to the cognate toxin but instead binds to MreB and FtsZ (the toxin targets), enhancing their polymerization by forming higher-order bundles G4278_04065 ENOG4108YGG dna repair protein G4278_04070 ENOG4105MFG Antirestriction protein G4278_04075 ENOG4106H6R UPF0380 protein G4278_04090 ENOG4108PZQ Inner membrane protein YeeR G4278_04095 ENOG4105F4K antigen 43 G4278_04105 ENOG4108P8R G4278_04140 ENOG4105E5H Transposase G4278_04150 ENOG4108YXQ IS66 Orf2 family protein G4278_04160 ENOG4105VNT transposase (IS4 family) protein G4278_04165 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) G4278_04170 ENOG4108REK sugar kinase G4278_04175 ENOG4107RGD Major Facilitator superfamily G4278_04185 ENOG41069FU Outer membrane channel protein allowing the entry of N- acetylneuraminic acid (Neu5Ac, the most abundant sialic acid on host cell surfaces) into the bacteria G4278_04190 ENOG4108MX5 Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses (By similarity) G4278_04215 ENOG4105D05 Receptor G4278_04265 ENOG4105F9F transposase G4278_04275 ENOG4105I1J Autotransporter G4278_04285 ENOG4105F1Y L-lysine 6-monooxygenase (NADPH) G4278_04290 ENOG4105DUU IucA IucC family protein G4278_04340 ENOG4105SZK Rz endopeptidase from lambdoid prophage DLP12 G4278_04400 ENOG4108UQV Membrane G4278_04405 ENOG4105CXN decarboxylase G4278_04410 ENOG4105EAA nucleoside G4278_04420 ENOG4105KMG Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and or repair of Fe-S clusters in biosynthetic enzymes (By similarity) G4278_04425 ENOG4105CEN a g-specific adenine glycosylase G4278_04435 ENOG41090ED Protein with unknown function (DUF469) G4278_04440 ENOG4105K33 Periplasmic Protein G4278_04445 ENOG4105HDK L-asparaginase G4278_04450 ENOG4106MH3 alpha helix chain G4278_04455 ENOG4105CSA Coproporphyrinogen iii oxidase G4278_04460 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) G4278_04470 ENOG4108VIA integral membrane protein G4278_04475 ENOG4105DFA alanine racemase domain protein G4278_04480 ENOG4105CZX twitching motility protein G4278_04495 ENOG4105D7Z glutathione synthase G4278_04500 ENOG4105QF0 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) G4278_04505 ENOG4105RWS endonuclease I G4278_04515 ENOG4107QNK )-transporter G4278_04535 ENOG4105DP5 Catalyzes the biosynthesis of agmatine from arginine (By similarity) G4278_04550 ENOG4108K0D peptidase, M48 G4278_04555 ENOG4105CV1 Transketolase (EC 2.2.1.1) G4278_04560 ENOG4105EPW hflc protein G4278_04565 ENOG4108X7Y Mannitol-specific cryptic phosphotransferase enzyme iia G4278_04570 ENOG4105CTS PTS system mannitol-specific G4278_04575 ENOG4105DXH Alcohol dehydrogenase zinc-binding domain protein G4278_04585 ENOG4108R4K DNA-binding, transcriptional regulator G4278_04590 ENOG4107Z1W Fructose transport system kinase G4278_04595 ENOG4108JJB ABC transporter G4278_04630 ENOG4105D2N Aldolase G4278_04635 ENOG4105D64 Mechanosensitive ion channel G4278_04640 ENOG4108ZUB Lysine exporter protein (Lyse ygga) G4278_04645 ENOG4105MPN Membrane G4278_04650 ENOG4105DEQ transcriptional regulator G4278_04655 ENOG4105D5P Methylmalonyl-coA mutase G4278_04675 ENOG4108JQ1 Dehydrogenase G4278_04685 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase G4278_04705 ENOG4107RAQ aminopeptidase G4278_04710 ENOG4105D0A hydroxylase G4278_04715 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family G4278_04725 ENOG4105D43 The glycine cleavage system catalyzes the degradation of glycine (By similarity) G4278_04735 ENOG4105CBI The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor G4278_04740 ENOG4105CS2 ec 3.2.1.21 G4278_04750 ENOG4108UT2 hemolysin iii G4278_04755 ENOG4106XY2 Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication (By similarity) G4278_04760 ENOG4105Y75 tpr repeat protein G4278_04765 ENOG4108YDB Toxic component of a toxin-antitoxin (TA) module. Overexpression leads to growth arrest after 5 hours, with initial elongation of cells, followed by swelling. The toxic effects are abrogated by coexpression with antitoxin CptB. Interacts with cytoskeletal proteins FtsZ and MreB G4278_04770 ENOG41071R3 Low-potential electron donor to a number of redox enzymes (By similarity) G4278_04775 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) G4278_04780 ENOG4105T95 Thiol disulfide interChange protein G4278_04785 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) G4278_04795 ENOG4105CRK lysyL-tRNA synthetase G4278_04800 ENOG4108ZEY Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity) G4278_04815 ENOG4105C2W permease G4278_04820 ENOG4105BZ8 glutamate synthase G4278_04825 ENOG4108R8B oxidoreductase Fe-S subunit G4278_04830 ENOG4105C7N Xanthine uracil vitamin C permease G4278_04835 ENOG4107QUY Guanine deaminase G4278_04840 ENOG4105C2W permease G4278_04845 ENOG4105C7W Xanthine dehydrogenase G4278_04850 ENOG410873Y FAD binding domain in molybdopterin dehydrogenase G4278_04855 ENOG4107UUR Chlorohydrolase aminohydrolase G4278_04860 ENOG4105BZ8 glutamate synthase G4278_04865 ENOG4105MFX 4-diphosphocytidyl-2c-methyl-d-erythritol synthase G4278_04870 ENOG4105MJ6 selenium-dependent hydroxylase accessory protein YqeC G4278_04875 ENOG4107P0T Selenium-dependent molybdenum hydroxylase system protein, YqeB family G4278_04880 ENOG4105C5B carbamate kinase G4278_04885 ENOG4105CD3 dihydroorotase G4278_04890 ENOG4107S4Y M20 DapE family protein YgeY G4278_04895 ENOG4107RCH Diaminopropionate ammonia-lyase G4278_04900 ENOG4105IW6 Carbamoyltransferase G4278_04905 ENOG4108JUB Transcriptional regulator G4278_04910 ENOG4108UTP (2Fe-2S)-binding domain protein G4278_04915 ENOG4108HR6 Dehydrogenase G4278_04920 ENOG4105C7W Xanthine dehydrogenase G4278_04925 ENOG4108K5P (LipO)protein G4278_04935 ENOG4108MHD transport protein G4278_04940 ENOG4105CHU acetyl-coa acetyltransferase G4278_04950 ENOG4105CHR reductase G4278_04955 ENOG4107QNK )-transporter G4278_04965 ENOG4105RQF LysR family Transcriptional regulator G4278_04975 ENOG41060NJ transcriptional regulator G4278_04985 ENOG4107S74 Lysophospholipid transporter LplT G4278_04990 ENOG4105CPC Aldo Keto reductase G4278_04995 ENOG4105SUV lipoprotein YgdR G4278_05000 ENOG4105EE5 Membrane protein terC G4278_05015 ENOG4108HRM phosphoenolpyruvate--protein phosphotransferase G4278_05030 ENOG4105IPU prepilin peptidase dependent protein A G4278_05035 ENOG4105JCS prepilin peptidase dependent protein G4278_05040 ENOG4105SEN Protein of unknown function (DUF2509) G4278_05045 ENOG4105RVB Prepilin peptidase dependent protein c G4278_05050 ENOG4105DSY exodeoxyribonuclease V, gamma G4278_05055 ENOG4107QXK peptidase G4278_05060 ENOG4107QKA exodeoxyribonuclease V beta G4278_05065 ENOG4107QYX exodeoxyribonuclease v alpha G4278_05070 ENOG4108EKC n-acetylglutamate synthase G4278_05075 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase G4278_05085 ENOG4105CI1 PTS System G4278_05090 ENOG4105C87 Aminotransferase class I and II G4278_05095 ENOG4105C2X Arabinose 5-phosphate isomerase G4278_05165 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit G4278_05175 ENOG4108ZG0 Ompa motb domain protein G4278_05215 ENOG4105CA3 membrane-bound lytic murein transglycosylase G4278_05220 ENOG4105CUZ uba thif-type nad fad binding protein G4278_05225 ENOG4105P9C Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity) G4278_05230 ENOG4105C9B Cysteine desulfurase G4278_05235 ENOG4105M5B (LipO)protein G4278_05240 ENOG4105ETT transcriptional Regulator, LysR family G4278_05245 ENOG4105M08 Membrane G4278_05255 ENOG4107EDW L-fucose operon activator G4278_05265 ENOG4105CMG Carbohydrate kinase G4278_05270 ENOG4105EHF Converts the aldose L-fucose into the corresponding ketose L-fuculose (By similarity) G4278_05275 ENOG4105EDR glucose galactose transporter G4278_05280 ENOG4107W7X Aldolase G4278_05285 ENOG4105C0A alcohol dehydrogenase G4278_05295 ENOG4105EJQ L-serine dehydratase G4278_05300 ENOG4105C44 Serine transporter G4278_05305 ENOG4105EWT decarboxylase family G4278_05320 ENOG4105WP7 tRNA pseudouridine synthase C G4278_05325 ENOG4105DR9 pseudouridine synthase G4278_05330 ENOG4105QDK Flavodoxin G4278_05335 ENOG4105DJB Major Facilitator Superfamily G4278_05340 ENOG4105EQX glucarate dehydratase G4278_05345 ENOG4105EQX glucarate dehydratase G4278_05350 ENOG4105BZU Histidine kinase G4278_05355 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) G4278_05360 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) G4278_05365 ENOG4105DXN mazG family G4278_05380 ENOG4105HA9 of methanol dehydrogenase type G4278_05390 ENOG4105HA9 of methanol dehydrogenase type G4278_05400 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) G4278_05405 ENOG4108CWB sugar kinase ygcE G4278_05410 ENOG4108ITV Inner membrane protein yqcE G4278_05415 ENOG4105CHR reductase G4278_05420 ENOG4107R3A FAD linked oxidase domain protein G4278_05430 ENOG4106IKH Electron transfer flavoprotein G4278_05435 ENOG4105YBM electron transfer flavoprotein subunit ygcQ G4278_05440 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator G4278_05445 ENOG4105WQV ferredoxin-like protein G4278_05450 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase G4278_05455 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase G4278_05460 ENOG4107EER Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate. The flavoprotein component catalyzes the electron flow from NADPH - FAD - FMN to the hemoprotein component (By similarity) G4278_05465 ENOG4105ET1 Component of the sulfite reductase complex that catalyzes the 6-electron reduction of sulfite to sulfide. This is one of several activities required for the biosynthesis of L- cysteine from sulfate (By similarity) G4278_05475 ENOG4107635 Hok Gef family protein G4278_05480 ENOG4108MXK alkaline phosphatase isozyme conversion G4278_05500 ENOG4105N0Z inner membrane protein ygbE G4278_05520 ENOG4106NZV Responsible for synthesis of pseudouridine from uracil- 13 in transfer RNAs (By similarity) G4278_05535 ENOG4108K5P (LipO)protein G4278_05540 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) G4278_05555 ENOG4105C6Z Gluconate G4278_05560 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) G4278_05570 ENOG4105G63 Type III effector Hrp-dependent G4278_05580 ENOG4105MVE transcriptional regulator G4278_05585 ENOG4105MEW serine threonine protein phosphatase G4278_05590 ENOG4105D86 that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity) G4278_05595 ENOG4105VXR cytoplasmic protein G4278_05605 ENOG4108JUA Transcriptional regulator G4278_05610 ENOG4105C45 hydrogenase expression formation protein (HypE) G4278_05615 ENOG4105CQS hydrogenase expression formation protein HypD G4278_05620 ENOG41083WG hydrogenase assembly chaperone G4278_05625 ENOG4107RSS Hydrogenase accessory protein HypB G4278_05630 ENOG410816D Probably plays a role in a hydrogenase nickel cofactor insertion step (By similarity) G4278_05635 ENOG4108VRC Formate hydrogenlyase regulatory protein hycA G4278_05640 ENOG4108MFN small subunit of hydrogenase-3, iron-sulfur protein (part of formate hydrogenlyase (FHL) complex) G4278_05645 ENOG4107R30 NADH dehydrogenase G4278_05650 ENOG4107TDF Formate hydrogenlyase subunit 4 G4278_05655 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) G4278_05660 ENOG4108RG7 formate hydrogenlyase complex iron-sulfur subunit G4278_05665 ENOG4105C47 NADH ubiquinone oxidoreductase 20 kda subunit G4278_05670 ENOG4105I6X formate hydrogenlyase maturation G4278_05675 ENOG4108MG9 hydrogenase 3 maturation protease G4278_05685 ENOG4105RVE Uncharacterized protein conserved in bacteria (DUF2136) G4278_05690 ENOG4108Z3N Transcriptional regulator G4278_05700 ENOG4108RC0 Electron transport protein G4278_05705 ENOG4105C8H hydrogenase maturation protein Hypf G4278_05710 ENOG4107QZF nitrite reductase NADPH large subunit G4278_05720 ENOG4108F2C Transcriptional regulator G4278_05725 ENOG4105C2X Arabinose 5-phosphate isomerase G4278_05730 ENOG410804X Transcriptional regulator G4278_05735 ENOG4105J92 DNA-binding transcriptional activator GutM G4278_05740 ENOG4107QMF Sorbitol-6-phosphate dehydrogenase G4278_05745 ENOG4105VI0 Pts system, glucitol sorbitol-specific G4278_05750 ENOG4105DZY Pts system, glucitol sorbitol-specific G4278_05755 ENOG410787A Pts system, glucitol sorbitol-specific G4278_05760 ENOG4105CVE Lytic murein transglycosylase G4278_05765 ENOG4107TH8 cina domain protein G4278_05785 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) G4278_05820 ENOG4107VXZ Hydrolase G4278_05825 ENOG4105W39 Membrane G4278_05850 ENOG4105C0R drug resistance transporter emrb qaca subfamily G4278_05855 ENOG4105CW7 secretion protein, HlyD family G4278_05860 ENOG4105NTK Transcriptional repressor Mpra G4278_05870 ENOG4105ZED uncharacterized protein ygaH G4278_05875 ENOG4108UMN azlc family G4278_05880 ENOG4105EQ0 Major Facilitator superfamily G4278_05885 ENOG4105GIJ Glycine betaine G4278_05890 ENOG4108HQS Glycine betaine G4278_05895 ENOG4108IJ7 Glycine betaine G4278_05900 ENOG4107R25 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) G4278_05905 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) G4278_05915 ENOG4105WAZ (Glutaredoxin-like protein) NrdH G4278_05920 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) G4278_05925 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family G4278_05930 ENOG4108ZQZ Bacterial protein of unknown function (DUF883) G4278_05935 ENOG4108WMJ Protein of unknown function (DUF2002) G4278_05940 ENOG4108RNS Exports L-alanine (By similarity) G4278_05945 ENOG4108X73 DNA- binding protein G4278_05950 ENOG4108V62 Rhodanese domain protein G4278_05955 ENOG41080HT Transcriptional regulator, arsr family G4278_05960 ENOG4105VPI YqaE family transport protein G4278_05965 ENOG4109066 lysm domain bon superfamily protein G4278_05970 ENOG4108PVQ transcriptional regulator G4278_05975 ENOG4105C85 amino acid G4278_05980 ENOG4108JPW Aminotransferase G4278_05985 ENOG4105C26 Dehydrogenase G4278_05990 ENOG4105D5U fad dependent oxidoreductase G4278_05995 ENOG4105EK3 May be involved in the control of utilization of gamma- aminobutyric acid (By similarity) G4278_06010 ENOG4108Z1B Cyclase dehydrase G4278_06020 ENOG4105YRI Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) G4278_06025 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) G4278_06040 ENOG4108JU6 CBS domain protein G4278_06045 ENOG4106KVJ cytochrome C assembly protein G4278_06050 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY G4278_06075 ENOG41090EK ompa motb domain protein G4278_06080 ENOG4108KHX Diguanylate cyclase G4278_06085 ENOG4108WS1 G4278_06090 ENOG4105QP9 Protein of unknown function (DUF2799) G4278_06095 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) G4278_06100 ENOG4105EHE chorismate mutase- prephenate dehydrogenase G4278_06105 ENOG4105CQC Prephenate dehydratase G4278_06115 ENOG4108WPH sigma 54 modulation protein ribosomal protein S30EA G4278_06120 ENOG4106SNF Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane G4278_06125 ENOG4105C34 Pseudouridine synthase G4278_06130 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase G4278_06135 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit G4278_06160 ENOG4105CSH Transporter G4278_06165 ENOG4105T42 (LipO)protein G4278_06170 ENOG4105JIM Phosphatidylserine synthase G4278_06175 ENOG4105CD5 CoA-binding domain protein G4278_06180 ENOG4106IUH DTW domain containing protein G4278_06185 ENOG4105K63 Thioredoxin G4278_06190 ENOG4105EIB trna rrna methyltransferase G4278_06210 ENOG41090KR LysR family transcriptional Regulator G4278_06215 ENOG4105C1J atp-dependent rna helicase G4278_06225 ENOG4108IYU L-aspartate oxidase G4278_06235 ENOG4105EMN RNA polymerase sigma factor G4278_06240 ENOG41069PW sigma-e factor negative regulatory protein G4278_06245 ENOG4105VQK sigma E regulatory protein, MucB RseB G4278_06250 ENOG4105WMJ Positive regulator of sigma E, RseC MucC G4278_06260 ENOG4105C3F Signal peptidase i G4278_06280 ENOG4105CSZ Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity) G4278_06295 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding G4278_06300 ENOG4106G6Q Transcriptional regulator G4278_06305 ENOG4105HYY HAD superfamily (Subfamily IF) hydrolase, YfhB G4278_06310 ENOG4108Z6B deaminase G4278_06315 ENOG4105CHQ Murein-degrading enzyme that degrades murein glycan strands and insoluble, high-molecular weight murein sacculi, with the concomitant formation of a 1,6-anhydromuramoyl product. Lytic transglycosylases (LTs) play an integral role in the metabolism of the peptidoglycan (PG) sacculus. Their lytic action creates space within the PG sacculus to allow for its expansion as well as for the insertion of various structures such as secretion systems and flagella (By similarity) G4278_06320 ENOG4108ETH Formylglycinamide ribotide synthetase G4278_06325 ENOG4107WP9 Histidine kinase G4278_06330 ENOG4108SKK alpha helix protein G4278_06335 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family G4278_06345 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) G4278_06355 ENOG4108NZE NAGC-like transcriptional regulator G4278_06360 ENOG4107HQ7 repeat protein G4278_06365 ENOG4105FCA ABC transporter periplasmic-binding protein YphF G4278_06370 ENOG4108F37 ATP-binding component of a transport system G4278_06375 ENOG4105CNN ABC, transporter G4278_06380 ENOG4105CPQ Dehydrogenase G4278_06385 ENOG4108ZKT aldose 1-epimerase G4278_06390 ENOG4108SB3 DoxX Family G4278_06395 ENOG4105D8G Major Facilitator superfamily G4278_06400 ENOG4108MN2 Stationary phase inducible protein CsiE G4278_06405 ENOG4107XM9 (LipO)protein G4278_06410 ENOG4105ECY inositol monophosphatase G4278_06430 ENOG4107XTC May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins G4278_06450 ENOG4108ZIT Ferredoxin, 2FE-2S G4278_06455 ENOG4105WVQ Fe-S assembly protein IscX G4278_06465 ENOG4105YYA enhanced serine sensitivity protein SseB G4278_06470 ENOG4105KHC sulfurtransferase G4278_06475 ENOG4105DN3 alpha-2-macroglobulin domain protein G4278_06480 ENOG4108JQB penicillin-binding protein 1C G4278_06490 ENOG4105C55 Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs G4278_06510 ENOG4105N21 Membrane G4278_06525 ENOG4105VPD cellular component movement G4278_06545 ENOG4105DVS Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity) G4278_06550 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) G4278_06560 ENOG41066DY Membrane G4278_06565 ENOG4108ZMA Outer membrane lipoprotein G4278_06570 ENOG41062G3 Protein of unknown function (DUF2633) G4278_06580 ENOG4105BZU Histidine kinase G4278_06585 ENOG4105C9X ppx gppa phosphatase G4278_06590 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) G4278_06595 ENOG4108V3E phosphoribosylglycinamide formyltransferase G4278_06610 ENOG4105C2W permease G4278_06615 ENOG4108KZ1 Mediates the interaction of DNA replication inititator protein DnaA with DNA polymerase subunit beta sliding clamp (dnaN). Stimulates hydrolysis of ATP-DnaA to ADP-DnaA, rendering DnaA inactive for reinititation, a process called regulatory inhibition of DnaA or RIDA (By similarity) G4278_06620 ENOG4105K89 arsenate reductase G4278_06625 ENOG4105ERG peptidase m48, ste24p G4278_06630 ENOG4105C02 permease G4278_06635 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen G4278_06640 ENOG4105RH4 Glycine cleavage system transcriptional repressor G4278_06650 ENOG4107EG0 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) G4278_06660 ENOG4105CGZ zinc metallopeptidase G4278_06670 ENOG4106KED esterase YpfH G4278_06685 ENOG4105KUZ arsenate reductase G4278_06695 ENOG4105BZS acriflavin resistance protein G4278_06700 ENOG4105BZU Histidine kinase G4278_06705 ENOG4105BZ8 glutamate synthase G4278_06715 ENOG4108PVD exported protein G4278_06720 ENOG4105CV1 Transketolase (EC 2.2.1.1) G4278_06725 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) G4278_06730 ENOG4105C6K Malic enzyme G4278_06735 ENOG4108VJN May be involved in the formation of a specific microcompartment in the cell in which the metabolism of potentially toxic by-products takes place G4278_06740 ENOG4106S4J ethanolamine utilization protein EutP G4278_06745 ENOG4105NDK ethanolamine utilization protein G4278_06750 ENOG4108PFF ethanolamine utilization cobalamin adenosyltransferase G4278_06755 ENOG4107WUY phosphate acetyltransferase G4278_06760 ENOG4105KNY Microcompartments protein G4278_06765 ENOG4105WVM ethanolamine utilization protein EutN carboxysome structural protein Ccml G4278_06770 ENOG4108EKI Dehydrogenase G4278_06775 ENOG4107RWI ethanolamine utilization protein eutJ G4278_06780 ENOG4105C0A alcohol dehydrogenase G4278_06785 ENOG4105ENY Ethanolamine utilization protein eutH G4278_06790 ENOG4105DYY Reactivating factor for ethanolamine ammonia lyase G4278_06795 ENOG4105CPD ethanolamine ammonia-lyase G4278_06805 ENOG4106D67 ethanolamine utilization protein G4278_06810 ENOG4108X49 Ethanolamine utilization protein EutK G4278_06815 ENOG4108K3Z AraC family transcriptional regulator G4278_06825 ENOG4108KNB n-acetylmuramoyl-l-alanine amidase G4278_06835 ENOG4105QZU Inner membrane protein YfeZ G4278_06840 ENOG4105E7K (LipO)protein G4278_06845 ENOG4105EZR dyp-type peroxidase family protein G4278_06850 ENOG4105C5Y PTS System G4278_06855 ENOG4105E15 Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6- phosphate and D-lactate G4278_06860 ENOG4105I7Z Short-chain dehydrogenase reductase Sdr G4278_06865 ENOG4108J2H Sulfate ABC transporter periplasmic sulfate-binding protein G4278_06870 ENOG4108I5D sulfate abc transporter G4278_06875 ENOG4105ECW sulfate abc transporter G4278_06880 ENOG4108IJ6 ABC transporter G4278_06885 ENOG4105C6T cysteine synthase G4278_06890 ENOG4105M0Y G4278_06900 ENOG4105C5Y PTS System G4278_06905 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) G4278_06915 ENOG4105C6T cysteine synthase G4278_06925 ENOG4107NPY receptor for the septal ring structure, may anchor it to the inner-membrane (By similarity) G4278_06935 ENOG4105VRT cytoplasmic protein G4278_06940 ENOG4105DHU Bile acid G4278_06945 ENOG4108M0I Transcriptional regulator G4278_06950 ENOG4108NFH Sugar hydrolase G4278_06955 ENOG4107U5R The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity) G4278_06960 ENOG4105EAA nucleoside G4278_06970 ENOG4105CN8 Transcriptional regulator G4278_06995 ENOG4105C20 Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity) G4278_07000 ENOG4105GXM Putative transcription regulator (DUF1323) G4278_07005 ENOG4105HZG regulatoR G4278_07020 ENOG4108KMM Diguanylate cyclase G4278_07025 ENOG4105D9N nucleoside G4278_07035 ENOG4109076 Conserved Protein G4278_07040 ENOG4105VCT ion-transport protein YfeO G4278_07050 ENOG4105R6B The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane (By similarity) G4278_07055 ENOG410863U PTS System G4278_07060 ENOG4105DC7 peptidase M24 G4278_07065 ENOG4105CN9 Peptidase m42 family protein G4278_07070 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) G4278_07075 ENOG4108CIP transcriptional regulator G4278_07080 ENOG4105DY9 regulatoR G4278_07085 ENOG4108HRK Histidine kinase G4278_07090 ENOG4105CHM Aminotransferase G4278_07100 ENOG4105D1S lipid A biosynthesis G4278_07105 ENOG4105W9M Membrane G4278_07115 ENOG4108V08 YfdX protein G4278_07120 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F G4278_07125 ENOG4105CFN oxalyl-CoA decarboxylase G4278_07130 ENOG4108N2Y auxin Efflux G4278_07135 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F G4278_07140 ENOG4105BZU Histidine kinase G4278_07145 ENOG4108WQH regulatoR G4278_07150 ENOG4105CW7 secretion protein, HlyD family G4278_07155 ENOG4105C0R drug resistance transporter emrb qaca subfamily G4278_07160 ENOG4105BZC d-serine deaminase G4278_07170 ENOG4105W8I Transcriptional regulator G4278_07175 ENOG4108W9T type 1 fimbriae regulatory protein G4278_07180 ENOG4108W9T type 1 fimbriae regulatory protein G4278_07205 ENOG4105S64 Formate nitrite transporter G4278_07210 ENOG410903C (LipO)protein G4278_07215 ENOG4105CKF membrane protein involved in aromatic hydrocarbon degradation G4278_07220 ENOG4105KZW UPF0381 protein G4278_07225 ENOG4105CHU acetyl-coa acetyltransferase G4278_07230 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase G4278_07235 ENOG4108BY2 phosphohistidine phosphatase G4278_07245 ENOG4106PG1 outer membrane usher protein G4278_07250 ENOG4108FZ9 Chaperone G4278_07255 ENOG4105NEV Fimbrial G4278_07260 ENOG4105UGQ Fimbrial G4278_07265 ENOG4105US4 fimbrial-like protein yfcP G4278_07285 ENOG4105D10 5-enolpyruvylshikimate-3-phosphate phospholyase G4278_07295 ENOG4105EJ9 Membrane G4278_07300 ENOG4108BPE -transporting atpase G4278_07305 ENOG4105MH2 YfcL protein G4278_07310 ENOG4105CWG Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity) G4278_07315 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) G4278_07320 ENOG4105F9N Major Facilitator Superfamily G4278_07325 ENOG4106WZ1 flagella biosynthesis regulator G4278_07335 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) G4278_07345 ENOG4105DQR SNARE associated Golgi G4278_07355 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase G4278_07360 ENOG4108S3P Sporulation domain protein G4278_07365 ENOG4105E96 Colicin v production protein G4278_07370 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase G4278_07375 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase G4278_07385 ENOG4105E89 ABC transporter G4278_07390 ENOG4105DSP amino acid AbC transporter G4278_07395 ENOG4106YG3 ABC transporter G4278_07400 ENOG4108JEH abc transporter atp-binding protein G4278_07405 ENOG4105ECP epimerase G4278_07410 ENOG4105KKP D-erythro-7,8-dihydroneopterin triphosphate 2'-epimerase G4278_07415 ENOG4105CYM Glutathione S-transferase G4278_07420 ENOG4108SHQ Glutathione S-transferase G4278_07425 ENOG4108RE9 Phosphodiesterase G4278_07430 ENOG4105PTV Nudix Hydrolase G4278_07435 ENOG4105CSX c4-dicarboxylate anaerobic carrier G4278_07440 ENOG4105C6K Malic enzyme G4278_07445 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) G4278_07450 ENOG4105PQ6 UPF0208 membrane protein G4278_07455 ENOG4105XWI UPF0304 protein G4278_07460 ENOG4105EVE HAD-superfamily hydrolase subfamily IA variant 3 G4278_07465 ENOG4107QWE )-transporter G4278_07475 ENOG4105CHM Aminotransferase G4278_07480 ENOG4107NQ8 LysR family Transcriptional regulator G4278_07500 ENOG4105GKE subunit e G4278_07505 ENOG4107QIZ NADH dehydrogenase G4278_07510 ENOG4108IEH NADH dehydrogenase subunit g G4278_07525 ENOG4107UFS subunit j G4278_07535 ENOG4105D65 subunit l G4278_07540 ENOG4105C8S subunit m G4278_07550 ENOG4105GDX Domain of unknown function (DUF1877) G4278_07555 ENOG4107VAM peptidase, m28 G4278_07560 ENOG4105CP2 von willebrand factor, type a G4278_07570 ENOG4107YB6 acetyltransferase, (GNAT) family G4278_07575 ENOG4105TNS Conserved Protein G4278_07580 ENOG4105E4F Isochorismate synthase G4278_07595 ENOG4108IPT Naphthoate synthase G4278_07600 ENOG4105DNI Converts SHCHC to OSB (By similarity) G4278_07605 ENOG4105CEY Amp-dependent synthetase and ligase G4278_07610 ENOG4106GZG polymyxin resistance protein B G4278_07625 ENOG4105SA9 Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity) G4278_07635 ENOG4105C3I Nad-dependent epimerase dehydratase G4278_07660 ENOG4108UII YfaZ family G4278_07665 ENOG4108EWA cinA-like protein G4278_07670 ENOG4107258 Transcriptional regulator G4278_07675 ENOG4105CXK mandelate racemase muconate lactonizing G4278_07680 ENOG4105CSP Major Facilitator Superfamily G4278_07690 ENOG4105DNE Transposase G4278_07695 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) G4278_07700 ENOG4108KJ0 anaerobic glycerol-3-phosphate dehydrogenase, subunit B G4278_07705 ENOG4107R5Y anaerobic glycerol-3-phosphate dehydrogenase, subunit A G4278_07710 ENOG4105CXY transporter G4278_07715 ENOG4106MZZ glycerophosphoryl diester phosphodiesterase G4278_07720 ENOG4105FQR PH-inducible protein involved in stress response G4278_07725 ENOG4105XPH Ferredoxin G4278_07730 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) G4278_07735 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) G4278_07740 ENOG4107GHC outer membrane autotransporter G4278_07745 ENOG4108HWB Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity) G4278_07750 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) G4278_07755 ENOG4107FKF Uncharacterized protein conserved in bacteria (DUF2138) G4278_07760 ENOG4108QJJ Protein of unknown function (DUF1175) G4278_07765 ENOG4107S52 alpha-2-macroglobulin domain protein G4278_07770 ENOG41081SK signal peptide protein G4278_07775 ENOG4105EDV vault protein G4278_07780 ENOG4105CHU acetyl-coa acetyltransferase G4278_07785 ENOG4105CRW Short chain fatty acid transporter G4278_07790 ENOG4107QNJ CoA-transferase subunit B G4278_07795 ENOG4107QP7 CoA-transferase subunit A G4278_07800 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family G4278_07805 ENOG4105BZU Histidine kinase G4278_07810 ENOG4105BZU Histidine kinase G4278_07815 ENOG41068CG regulatoR G4278_07820 ENOG4105E3G Phosphotransfer intermediate protein in two-component regulatory system with RcsBC G4278_07825 ENOG4105FCK Membrane G4278_07830 ENOG4105CJ2 (LipO)protein G4278_07835 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) G4278_07840 ENOG4105CF1 Alkylated DNA repair protein G4278_07845 ENOG4105IBP Cyclic peptide transporter G4278_07850 ENOG4105DWT malate dehydrogenase (quinone) G4278_07860 ENOG4108ZNS ferredoxin-type protein NapF G4278_07865 ENOG41061Q0 Assembly protein for periplasmic nitrate reductase G4278_07875 ENOG4108BGM Quinol dehydrogenase periplasmic component G4278_07880 ENOG4105GXZ Ferredoxin-type protein NapH G4278_07885 ENOG4108ZMS Electron transfer subunit of the periplasmic nitrate reductase complex NapAB (By similarity) G4278_07890 ENOG4105CUW cytochrome C-TYPE protein G4278_07895 ENOG4107EV4 once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system (By similarity) G4278_07900 ENOG4105CA5 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes (By similarity) G4278_07905 ENOG41060IM Heme exporter protein G4278_07910 ENOG4105X3C heme exporter protein G4278_07920 ENOG4105DA4 cytochrome c-type biogenesis protein G4278_07925 ENOG4107QX9 Thiol disulfide interChange protein G4278_07930 ENOG4105KWW Biogenesis protein G4278_07935 ENOG4105WH1 Two component transcriptional regulator luxr family G4278_07945 ENOG4108MGN ATP-binding component of a transport system G4278_07955 ENOG4105E68 Sulfatase G4278_07975 ENOG4105CFI type iii restriction protein res subunit G4278_07980 ENOG4105I08 Pseudouridine synthase G4278_07985 ENOG4105C2C drug resistance transporter, Bcr CflA G4278_07990 ENOG4105HG6 G4278_07995 ENOG4108JQ5 ABC transporter G4278_08000 ENOG4108IYQ Binding-protein-dependent transport systems inner membrane component G4278_08005 ENOG4108I5X binding-protein-dependent transport systems inner membrane Component G4278_08010 ENOG4105E43 Extracellular solute-binding protein, family 5 G4278_08015 ENOG4105CXC rtn protein G4278_08020 ENOG4107TT5 NLP P60 protein G4278_08025 ENOG41076MN Phosphoesterase, PA-phosphatase related G4278_08030 ENOG4105CKI cobalamin synthesis protein G4278_08035 ENOG4105DEI Mannitol dehydrogenase G4278_08045 ENOG4105KRS Proteinase inhibitor G4278_08055 ENOG4105DTZ bifunctional PTS system fructose-specific transporter subunit IIA HPr protein G4278_08060 ENOG4105DE4 1-phosphofructokinase G4278_08065 ENOG4105DM4 PTS System G4278_08070 ENOG4105DD7 kinase (PfkB family G4278_08075 ENOG4105D53 Catalyzes the hydrolysis of pseudouridine 5'-phosphate (PsiMP) to ribose 5-phosphate and uracil (By similarity) G4278_08080 ENOG4105D9N nucleoside G4278_08085 ENOG4108Y4K DNA-binding transcriptional activator G4278_08095 ENOG4105DD7 kinase (PfkB family G4278_08105 ENOG4105HMI Membrane G4278_08110 ENOG4105DUM transcriptional regulator, lysR family G4278_08115 ENOG4108IQI permease G4278_08120 ENOG4105D05 Receptor G4278_08125 ENOG4105C4W S-formylglutathione hydrolase G4278_08135 ENOG4105DHF Membrane G4278_08140 ENOG41060NJ transcriptional regulator G4278_08145 ENOG4105EMA Periplasmic binding protein LacI transcriptional regulator G4278_08150 ENOG4105C2J ABC transporter G4278_08155 ENOG4108HWV )-transporter G4278_08160 ENOG4107SJI Dehydrogenase G4278_08165 ENOG4105BZ8 glutamate synthase G4278_08170 ENOG4105Y9N Membrane G4278_08175 ENOG4107GZ4 SanA protein G4278_08185 ENOG41067MG lrgb family G4278_08195 ENOG4105FBT Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity) G4278_08205 ENOG4105ETP RND efflux system, outer membrane lipoprotein G4278_08215 ENOG4105KHU inner membrane protein YohD G4278_08220 ENOG41069YE inner membrane protein yohC G4278_08225 ENOG41061WM D-Alanyl-D-Alanine G4278_08230 ENOG4105CXG d-lactate dehydrogenase G4278_08235 ENOG4107QK4 glycoside hydrolase, family 3 domain protein G4278_08240 ENOG4107SI7 Substrate-binding region of abc-type glycine betaine transport system G4278_08245 ENOG4107T5X Binding-protein-dependent transport systems, inner membrane component G4278_08250 ENOG4108IJ8 ABC transporter G4278_08255 ENOG4105WJV Binding-protein-dependent transport systems, inner membrane component G4278_08265 ENOG4108XDN Transcriptional regulator G4278_08270 ENOG4108HRK Histidine kinase G4278_08275 ENOG4108NEV two component transcriptional regulator, LytTR family G4278_08280 ENOG4108W15 Protein of unknown function (DUF1456) G4278_08285 ENOG4108YCW (LipO)protein G4278_08290 ENOG410903U zinc ion binding G4278_08295 ENOG4105DEG Vwa containing coxe family protein G4278_08300 ENOG4105RD5 G4278_08305 ENOG4105KKX ATPase associated with various cellular activities aaa_5 G4278_08315 ENOG4108KDT Molybdate metabolism regulator G4278_08320 ENOG4108KDT Molybdate metabolism regulator G4278_08330 ENOG4105D1F ATP-binding protein G4278_08335 ENOG41067AK Protein of unknown function (DUF2574) G4278_08340 ENOG41063W2 Fimbrial protein G4278_08345 ENOG4108MQF Chaperone G4278_08350 ENOG4105CW0 outer membrane usher protein G4278_08355 ENOG410662B Type-1 fimbrial protein G4278_08360 ENOG4108Z1S Influences nickel and cobalt homeostasis. May act by modulating RcnA-mediated export of these ions to avoid excess efflux. Not involved in nickel import and does not bind nickel or cobalt ions directly G4278_08375 ENOG4105C4U 4-methyl-5-beta-hydroxyethylthiazole kinase G4278_08380 ENOG4105DWF phosphomethylpyrimidine kinase G4278_08385 ENOG4108UQ1 hydrolase, family 25 G4278_08390 ENOG4105FDP GntR family transcriptional regulator G4278_08395 ENOG4108TFM Kinase, PfkB family G4278_08400 ENOG4108KD5 ADP-ribosylation crystallin J1 G4278_08405 ENOG4105EAA nucleoside G4278_08410 ENOG4105EIE fructose-bisphosphate aldolase G4278_08415 ENOG4105D2N Aldolase G4278_08420 ENOG4105C6Q that is required for full activity and stability of the Y subunit. Could have a chaperone-like function for the proper and stable folding of G4278_08425 ENOG41082GB PTS system galactitol-specific transporter subunit IIA G4278_08430 ENOG41090UW PTS System G4278_08435 ENOG4105DT3 PTS system, galactitol-specific IIc component G4278_08440 ENOG4107WTH Galactitol-1-phosphate dehydrogenase G4278_08450 ENOG4107TE5 Lipid kinase G4278_08455 ENOG41076Z6 Uncharacterized protein yegR G4278_08460 ENOG4105CFP Peptidase U32 G4278_08485 ENOG4105KWI UPF0339 protein G4278_08490 ENOG4105E3W Two component transcriptional regulator (Winged helix family G4278_08495 ENOG4105EB3 Histidine kinase G4278_08500 ENOG4105C0R drug resistance transporter emrb qaca subfamily G4278_08505 ENOG4105BZS acriflavin resistance protein G4278_08515 ENOG4105ENT Efflux transporter rnd family, mfp subunit G4278_08530 ENOG4108M24 von Willebrand factor, type A G4278_08535 ENOG4105UM3 Inherit from NOG: serine threonine phosphoprotein phosphatase G4278_08540 ENOG4106E1W protein with protein kinase and helix-hairpin-helix DNA-binding G4278_08545 ENOG4105R8A Heat shock protein G4278_08550 ENOG4105D03 DNA-3-methyladenine glycosylase II G4278_08555 ENOG4105BZU Histidine kinase G4278_08560 ENOG4105DBI uridine monophosphokinase G4278_08570 ENOG4108GAE asmA family G4278_08575 ENOG4105EE5 Membrane protein terC G4278_08580 ENOG4105DAY polysaccharide export protein G4278_08585 ENOG4105KJF protein tyrosine phosphatase G4278_08590 ENOG4105D75 Capsular exopolysaccharide family G4278_08595 ENOG41090RK glycosyl transferase G4278_08600 ENOG41068PY Colanic acid biosynthesis acetyltransferase wcaB G4278_08605 ENOG4107RXY Glycosyl transferase G4278_08610 ENOG4108NYJ Colanic acid G4278_08615 ENOG4105ECJ Glycosyl Transferase G4278_08620 ENOG4108Z90 colanic acid biosynthesis acetyltransferase wcaF G4278_08625 ENOG4105C0K Gdp-mannose 4,6-dehydratase G4278_08630 ENOG4105C30 Nad-dependent epimerase dehydratase G4278_08635 ENOG4105FGF GDP-mannose mannosyl hydrolase G4278_08640 ENOG4106CD9 glycosyl transferase group 1 G4278_08645 ENOG4105CJT Mannose-1-phosphate guanylyltransferase G4278_08650 ENOG4107QKV phosphomannomutase G4278_08655 ENOG4105D3Q Sugar transferase G4278_08660 ENOG4105PSV Polysaccharide Biosynthesis Protein G4278_08665 ENOG4105C74 pyruvyl transferase G4278_08670 ENOG4107T8Q Glycosyl transferase (Group 1 G4278_08675 ENOG4105G1A colanic acid biosynthesis protein G4278_08680 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase G4278_08695 ENOG4105K64 Glycosyl transferase, family 2 G4278_08710 ENOG4105CMR udp-glucose 4-epimerase G4278_08720 ENOG4105CJT Mannose-1-phosphate guanylyltransferase G4278_08725 ENOG4107QKV phosphomannomutase G4278_08730 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) G4278_08735 ENOG4105C6Y Udp-glucose 6-dehydrogenase G4278_08740 ENOG4108KPN Confers a modal distribution of chain length on the O- antigen component of lipopolysaccharide (LPS). Gives rise to a reduced number of short chain molecules and increases in numbers of longer molecules, with a modal value of 13 (in strain O111 M92) and of 17 (in strain K12) G4278_08745 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase G4278_08750 ENOG4105C0S IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity) G4278_08755 ENOG4105CJV Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase G4278_08760 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) G4278_08765 ENOG4105ECC imidazole-glycerol-phosphate dehydratase G4278_08770 ENOG4105CIH Imidazole acetol-phosphate transaminase G4278_08775 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) G4278_08790 ENOG4105VTW prevent-host-death family G4278_08795 ENOG4105KRQ Addiction module toxin, Txe YoeB family G4278_08800 ENOG4107SRH Nad-dependent epimerase dehydratase G4278_08805 ENOG4105EQ1 Transcriptional regulator G4278_08815 ENOG4105CUB amino acid G4278_08820 ENOG4105CJB Exodeoxyribonuclease I G4278_08825 ENOG4105DZ1 carboxypeptidase G4278_08835 ENOG4105DR8 Membrane G4278_08870 ENOG4105MAW Antitoxin component of a toxin-antitoxin (TA) module. Labile antitoxin that counteracts the effect of the CbtA (YeeV) toxin. It does not bind to the cognate toxin but instead binds to MreB and FtsZ (the toxin targets), enhancing their polymerization by forming higher-order bundles G4278_08880 ENOG4108YGG dna repair protein G4278_08885 ENOG4106549 Antirestriction protein G4278_08890 ENOG4106H6R UPF0380 protein G4278_08910 ENOG4108YIV G4278_08915 ENOG4108F5E vimentin G4278_08935 ENOG4105EHG Permease protein G4278_08940 ENOG4108F1U ABC transporter G4278_08990 ENOG410836F Transposase G4278_09025 ENOG41080QX K07048 phosphotriesterase-related protein G4278_09040 ENOG4108RVA ribokinase G4278_09050 ENOG4105SRB Uncharacterized protein yaiO G4278_09055 ENOG4107RMY Bacterial transferase hexapeptide repeat protein G4278_09060 ENOG4108PBI Polysaccharide metabolism G4278_09065 ENOG4107W19 lmbE family G4278_09070 ENOG4105BZV Phosphoadenosine phosphosulfate reductase G4278_09075 ENOG4105GTN ParB Domain Protein Nuclease G4278_09085 ENOG4108YZT Adenosylcobinamide kinase G4278_09100 ENOG4108PXI ErfK YbiS YcfS YnhG G4278_09130 ENOG4105WH1 Two component transcriptional regulator luxr family G4278_09145 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase G4278_09150 ENOG4105X96 Involved in the biosynthesis of D-alanyl-lipoteichoic acid (LTA). Activated D-alanyl-Dcp donates its D-alanyl substituent to membrane-associated LTA (By similarity) G4278_09155 ENOG4105C1G acyl-Coa dehydrogenase G4278_09180 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) G4278_09205 ENOG4108VTW Thioesterase G4278_09225 ENOG4105UQX Mate efflux family protein G4278_09235 ENOG4107R11 Transcriptional regulator G4278_09240 ENOG4106P55 Transcriptional regulator G4278_09250 ENOG4105CDY transcriptional regulatory protein G4278_09255 ENOG4105FYV Amp nucleosidase G4278_09260 ENOG4105CSH Transporter G4278_09270 ENOG4105TNG K13735 adhesin invasin G4278_09275 ENOG4105TNG K13735 adhesin invasin G4278_09280 ENOG4105TNG K13735 adhesin invasin G4278_09285 ENOG4107ZSV Receptor G4278_09290 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase G4278_09310 ENOG4105C0W non-ribosomal peptide synthetase G4278_09325 ENOG4105BZ1 (ABC) transporter G4278_09330 ENOG4105EYM Major Facilitator superfamily G4278_09390 ENOG4108YX2 DNA-binding protein G4278_09485 ENOG4105DFP Integrase G4278_09490 ENOG4108MEK Metal-binding protein YodA G4278_09495 ENOG4105DQ2 Is probably involved in the electron transfer between its heme and the molybdenum cofactor of the reductase catalytic subunit YedY (By similarity) G4278_09500 ENOG4105CCD The exact function is not known. Can catalyze the reduction of a variety of substrates like dimethyl sulfoxide, trimethylamine N-oxide, phenylmethyl sulfoxide and L-methionine sulfoxide. Cannot reduce cyclic N-oxides. Shows no activity as sulfite oxidase (By similarity) G4278_09505 ENOG4105VT2 5-hydroxyisourate hydrolase G4278_09510 ENOG4105CK6 Two component transcriptional regulator (Winged helix family G4278_09515 ENOG4107ZY3 Histidine kinase G4278_09525 ENOG4105ZIT Porin Gram-negative type G4278_09530 ENOG4105Y0K Inner membrane protein YedR G4278_09535 ENOG4105EST Metal Dependent Phosphohydrolase G4278_09540 ENOG4105DVF Cytosine-specific methyltransferase G4278_09545 ENOG41090BB DNA mismatch endonuclease (vsr) G4278_09550 ENOG4105FDR Membrane G4278_09555 ENOG4105CKW Inner membrane protein yedI G4278_09560 ENOG4105VNZ cytoplasmic protein G4278_09565 ENOG4105BZU Histidine kinase G4278_09570 ENOG4108ZFX Mannosyl-3-phosphoglycerate phosphatase G4278_09575 ENOG4105YX3 cellular response to acidity G4278_09585 ENOG4107TKS colanic acid capsular biosynthesis activation protein A G4278_09590 ENOG4105D19 Role in flagellar biosynthesis (By similarity) G4278_09600 ENOG4105CN7 Flagellar biosynthetic protein FliP G4278_09605 ENOG4105K0P flagellar biosynthesis protein G4278_09610 ENOG4105DD5 Flagellar motor switch protein G4278_09615 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) G4278_09620 ENOG4107ZI8 flagellar basal body-associated protein flil G4278_09625 ENOG4105WF4 Flagellar hook-length control protein G4278_09630 ENOG4105GSA Flagellar export protein flij G4278_09635 ENOG4108JIR Flagellum-specific ATP synthase G4278_09640 ENOG41090PJ Flagellar assembly protein G4278_09645 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) G4278_09650 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) G4278_09660 ENOG410814C multidrug resistance protein G4278_09665 ENOG4108V1U phospholipid-binding protein G4278_09670 ENOG4108UQN AraC family transcriptional regulator G4278_09685 ENOG4108RAV Conserved protein G4278_09695 ENOG41066VF YeeE YedE family protein G4278_09700 ENOG4108W9D (LipO)protein G4278_09705 ENOG4105E5K Alpha-amylase G4278_09715 ENOG4105MQ3 flagellar protein FliS G4278_09720 ENOG4105DTS flagellar hook-associated G4278_09725 ENOG4105I03 Flagellin G4278_09730 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) G4278_09735 ENOG4108M9K flagella biosynthesis protein FliZ G4278_09740 ENOG4105EAB amino acid AbC transporter G4278_09745 ENOG4105K6H D-cysteine desulfhydrase G4278_09750 ENOG4105E5Q amino acid AbC transporter G4278_09755 ENOG4105CDA abc transporter atp-binding protein G4278_09760 ENOG4105VJY transcriptional regulator G4278_09765 ENOG4105XVG cytoplasmic protein G4278_09775 ENOG4105WH1 Two component transcriptional regulator luxr family G4278_09805 ENOG4106RHG Yeca family G4278_09810 ENOG4105E0U tyrosine-specific transport protein G4278_09815 ENOG4105VVZ metal-binding protein G4278_09820 ENOG41090A1 ferritin G4278_09825 ENOG4105P23 (LipO)protein G4278_09835 ENOG4105N4N Protein of unknown function (DUF2766) G4278_09840 ENOG4108UEC Ferritin-like protein G4278_09845 ENOG4105DMK Periplasmic binding protein LacI transcriptional regulator G4278_09850 ENOG4105C2J ABC transporter G4278_09855 ENOG4105CNN ABC, transporter G4278_09860 ENOG4108K4C ec 3.1.3.12 G4278_09865 ENOG4105C1K alpha-alpha-trehalose-phosphate synthase G4278_09870 ENOG4108VA4 Universal stress protein G4278_09880 ENOG4106CIA Functions in complex with FlhD as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region G4278_09885 ENOG4107RD7 Flagellar Motor Protein, MotA G4278_09890 ENOG4105ER2 Ompa motb domain protein G4278_09895 ENOG4105CBS Chea signal transduction histidine kinase G4278_09900 ENOG4108V3W Chemotaxis protein, CheW G4278_09905 ENOG4105C8Q Methyl-accepting chemotaxis G4278_09915 ENOG4105BZU Histidine kinase G4278_09925 ENOG4108VYJ response regulator receiver protein G4278_09930 ENOG4108KCC Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P) (By similarity) G4278_09935 ENOG4105D00 flagellar biosynthetic protein flhB G4278_09945 ENOG4105W13 flagellar protein G4278_09950 ENOG4105C75 arginyL-tRNA synthetase G4278_09955 ENOG4106ZCM YecM protein G4278_09965 ENOG4105CUW cytochrome C-TYPE protein G4278_09970 ENOG4108J2R molybdopterin oxidoreductase G4278_09975 ENOG4105PFA Catalyzes the conversion of 5-hydroxyuridine (ho5U) to 5-methoxyuridine (mo5U) at position 34 in tRNA (By similarity) G4278_09985 ENOG4105WJG Glutathione G4278_09990 ENOG41081XQ Conserved Protein G4278_09995 ENOG4105D3W isochorismatase G4278_10005 ENOG4108TIT dATP pyrophosphohydrolase G4278_10010 ENOG4105CDY transcriptional regulatory protein G4278_10020 ENOG4107S01 Repressor protein MetJ G4278_10040 ENOG4105FAV ABC, transporter G4278_10050 ENOG4105NXV High-affinity zinc uptake system protein G4278_10055 ENOG4105DR5 peptidase G4278_10060 ENOG4105NWR lipid A biosynthesis (Kdo)2-(Lauroyl)-lipid IVA acyltransferase G4278_10065 ENOG4105CA9 Pyruvate kinase G4278_10070 ENOG4106KNT transcriptional regulator G4278_10075 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase G4278_10080 ENOG4105C01 Dihydroxy-acid dehydratase G4278_10085 ENOG4108UHU Aldolase G4278_10095 ENOG4105X2V dna damage-inducible protein G4278_10105 ENOG4108Q2J Inner membrane protein YebE G4278_10115 ENOG4105UMD exodeoxyribonuclease X G4278_10120 ENOG4108YGA nitrilase cyanide hydratase and apolipoprotein n-acyltransferase G4278_10125 ENOG4105MPK DNA polymerase III subunit theta G4278_10130 ENOG4105FXM Copper resistance protein G4278_10135 ENOG4108PNC copper resistance G4278_10140 ENOG4105NKT exported protein G4278_10145 ENOG4108R1E Serine threonine protein phosphatase 1 G4278_10150 ENOG4105UVW uncharacterized protein yebW G4278_10155 ENOG4105WT8 Protein of unknown function (DUF1480) G4278_10165 ENOG4105DY2 Paraquat-inducible protein b G4278_10170 ENOG4105H2K paraquat-inducible protein a G4278_10175 ENOG4108ZGC gaf domain protein G4278_10185 ENOG4105CN1 protease G4278_10195 ENOG4105C0R drug resistance transporter emrb qaca subfamily G4278_10200 ENOG4105J4Q Transcriptional regulator G4278_10205 ENOG4105TIK G4278_10215 ENOG4105Q3Y exported protein G4278_10230 ENOG4105DHI Methyltransferase G4278_10245 ENOG4105F3R pts system mannose fructose sorbose family iid G4278_10250 ENOG4105ETZ PTS System G4278_10255 ENOG4105DAS pts system G4278_10260 ENOG4105EE5 Membrane protein terC G4278_10265 ENOG4107XTP (EAL) domain protein G4278_10270 ENOG4105EJQ L-serine dehydratase G4278_10275 ENOG4105P8F nudix hydrolase G4278_10280 ENOG4105CRQ synthase (Component I) G4278_10290 ENOG4105V2F Uncharacterized protein yoac G4278_10295 ENOG4105M4H endoribonuclease L-psp G4278_10300 ENOG4105DVT helicase G4278_10305 ENOG41072GX Peptidase M22 Glycoprotease G4278_10310 ENOG4105Y4Z Outer Membrane Lipoprotein G4278_10315 ENOG4105CEY Amp-dependent synthetase and ligase G4278_10320 ENOG4105ZIE Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity) G4278_10325 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) G4278_10340 ENOG4108YS1 cytoplasmic protein G4278_10345 ENOG4105YP6 Domain of unknown function (DUF1869) G4278_10350 ENOG4105Y3U Transglycosylase-associated protein G4278_10360 ENOG4106G4W G4278_10365 ENOG410620I Diguanylate cyclase G4278_10370 ENOG4105UCG Domain of unknown function (DUF333) G4278_10375 ENOG4105K78 MarR family Transcriptional regulator G4278_10380 ENOG4105DJ2 Major Facilitator Superfamily G4278_10385 ENOG4105R1U AraC Family Transcriptional Regulator G4278_10400 ENOG4108KXH Ybak prolyl-tRNA synthetase associated G4278_10405 ENOG4108KHP Diguanylate cyclase G4278_10410 ENOG4106KTS Inner membrane protein yeaI G4278_10420 ENOG4105CYN Serine protein kinase G4278_10425 ENOG4105GNX MltA-interacting MipA family protein G4278_10430 ENOG4105CV8 reductase G4278_10435 ENOG4105DSB aldose 1-epimerase G4278_10440 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase G4278_10450 ENOG4105VUT cytoplasmic protein G4278_10455 ENOG4105CPQ Dehydrogenase G4278_10460 ENOG4107TE1 transport protein G4278_10465 ENOG4105CPQ Dehydrogenase G4278_10470 ENOG4105D2N Aldolase G4278_10475 ENOG4107UH8 sugar kinase G4278_10480 ENOG4105CPC Aldo Keto reductase G4278_10485 ENOG4105E98 transcriptional regulator DeoR family G4278_10490 ENOG4108KUU Inner membrane metabolite transport protein ydjE G4278_10495 ENOG4108RWI nicotinamidase G4278_10500 ENOG4105HDK L-asparaginase G4278_10505 ENOG4105D07 Signal peptide peptidase, SppA G4278_10510 ENOG41069NU Nitroreductase G4278_10515 ENOG4105D4F Synthesizes selenophosphate from selenide and ATP (By similarity) G4278_10520 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) G4278_10530 ENOG4105F7F Chaperone G4278_10540 ENOG4105D82 Glutamate dehydrogenase G4278_10545 ENOG4105MTM Protein of unknown function (DUF1496) G4278_10550 ENOG4105M6F mutator MutT protein G4278_10555 ENOG4108T9J Cdp-alcohol phosphatidyltransferase G4278_10560 ENOG4107RM6 sulfurtransferase G4278_10565 ENOG4108VGW abc transporter atp-binding protein G4278_10570 ENOG4105CXZ ABC transporter, permease G4278_10575 ENOG4105VNH ABC transporter solute-binding protein G4278_10580 ENOG4107ZN8 Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) G4278_10585 ENOG4108N5C SNARE associated Golgi protein-related protein G4278_10590 ENOG4108KCW iron-sulfur cluster binding G4278_10595 ENOG4108RSN SNARE associated Golgi G4278_10600 ENOG4105CGK Exodeoxyribonuclease III G4278_10615 ENOG4105C26 Dehydrogenase G4278_10620 ENOG4105EY2 Catalyzes the hydrolysis of N(2)-succinylarginine into N(2)-succinylornithine, ammonia and CO(2) (By similarity) G4278_10630 ENOG4108SPG Periplasmic Protein G4278_10640 ENOG4105DKD Incises the DNA at the 3' side of a lesion during nucleotide excision repair. Incises the DNA farther away from the lesion than UvrC. Not able to incise the 5' site of a lesion. When a lesion remains because UvrC is not able to induce the 3' incision, Cho incises the DNA. Then UvrC makes the 5' incision. The combined action of Cho and UvrC broadens the substrate range of nucleotide excision repair (By similarity) G4278_10645 ENOG4107RA1 nh(3)-dependent nad( ) synthetase G4278_10650 ENOG4105KKI DNA-binding transcriptional activator OsmE G4278_10655 ENOG4105VZJ PTS System G4278_10660 ENOG4105CK1 PTS System G4278_10665 ENOG4105VCP PTS System G4278_10670 ENOG4105EZV Transcriptional regulator G4278_10675 ENOG4105F8D glycoside hydrolase family 4 G4278_10680 ENOG410901P UPF0249 protein G4278_10685 ENOG4105CH6 catalase G4278_10695 ENOG4108ETY sodium dicarboxylate symporter G4278_10700 ENOG4107K5X Membrane-bound metal-dependent hydrolase G4278_10705 ENOG4107UW8 HAD-superfamily hydrolase subfamily IA variant 3 G4278_10710 ENOG4107PN8 YfeABCD locus regulator G4278_10720 ENOG4105P10 Uncharacterized protein ydiZ G4278_10725 ENOG4105DE4 1-phosphofructokinase G4278_10730 ENOG4108NE3 Salt-induced outer membrane protein G4278_10750 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) G4278_10755 ENOG41082NX 50s ribosomal protein l35 G4278_10785 ENOG4108ESU Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Involved in the translocation of the substrate across the membrane (By similarity) G4278_10790 ENOG4108V06 Glutathione peroxidase G4278_10800 ENOG4108QBX (LipO)protein G4278_10805 ENOG4108TC0 Diguanylate phosphodiesterase G4278_10820 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) G4278_10830 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) G4278_10835 ENOG4105CEY Amp-dependent synthetase and ligase G4278_10840 ENOG41090P5 ferredoxin-like protein G4278_10845 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase G4278_10850 ENOG4105C10 Electron transfer flavoprotein G4278_10855 ENOG4105CV7 Electron transfer flavoprotein G4278_10860 ENOG4105W4W Transcriptional regulator G4278_10865 ENOG4105C1G acyl-Coa dehydrogenase G4278_10870 ENOG4107R0K CoA transferase having broad substrate specificity for short-chain acyl-CoA thioesters with the activity decreasing when the length of the carboxylic acid chain exceeds four carbons (By similarity) G4278_10885 ENOG4105EMV Major Facilitator G4278_10890 ENOG4105EMV Major Facilitator G4278_10895 ENOG4105SUA Ydil protein G4278_10905 ENOG4105IPI Membrane G4278_10910 ENOG4105CQB FAD linked oxidase domain protein G4278_10915 ENOG4105KA0 thioesterase Superfamily protein G4278_10920 ENOG410671Z uncharacterized protein ydiH G4278_10925 ENOG4108Z4V iron-sulfur cluster assembly G4278_10930 ENOG4105DIW FeS assembly protein SUFB G4278_10935 ENOG4105C3K feS assembly ATPase SufC G4278_10940 ENOG4105JRK feS assembly protein SufD G4278_10955 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein G4278_10960 ENOG4105KMX major outer membrane lipoprotein G4278_10965 ENOG4105CA9 Pyruvate kinase G4278_10970 ENOG4105RFR Protein of unknown function (DUF2767) G4278_10975 ENOG4108PU5 4fe-4S ferredoxin, iron-sulfur binding domain protein G4278_10980 ENOG4105WE2 aldehyde ferredoxin oxidoreductase G4278_10985 ENOG4105JVW G4278_10990 ENOG4108393 oxidoreductase Fe-S subunit G4278_10995 ENOG4108NWD Cytochrome G4278_11000 ENOG4108Y7C Conserved Protein G4278_11005 ENOG4108KTU conserved protein with FAD NAD(P)-binding domain G4278_11010 ENOG4105N0V mono-oxygenase ydhR G4278_11035 ENOG4108R6K riboflavin synthase, subunit alpha G4278_11040 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase G4278_11045 ENOG4105CZQ inner membrane transport protein YdhC G4278_11050 ENOG4105F52 Transcriptional regulator G4278_11055 ENOG4105ETE Transcriptional regulator (LacI family G4278_11065 ENOG4105F27 Major Facilitator G4278_11070 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) G4278_11075 ENOG4105K4H Nlp p60 protein G4278_11080 ENOG4105M2J Glutaredoxin G4278_11085 ENOG4107QRT dEAD DEAH box helicase G4278_11095 ENOG4108UYE Lactoylglutathione lyase G4278_11100 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase G4278_11105 ENOG4108WUH Transcriptional regulator, TetR family G4278_11110 ENOG4105XZD Fe-S protein G4278_11115 ENOG4107RGM aldo keto reductase G4278_11120 ENOG4108Z7T Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) G4278_11125 ENOG4105DSW Fusaric acid resistance protein G4278_11130 ENOG4105Y49 secretion protein, HlyD family G4278_11145 ENOG4108XTF Outer Membrane Lipoprotein G4278_11155 ENOG410642K Lysozyme inhibitor G4278_11170 ENOG4107XGF functions in a salvage pathway. Uses pyridoxamine (By similarity) G4278_11175 ENOG4108K3A Glutathione S-transferase G4278_11180 ENOG4105DUX Transporter G4278_11185 ENOG4105CSM endonuclease III G4278_11190 ENOG4105DZB Electron transport complex G4278_11195 ENOG4108UQQ Electron transport complex G4278_11200 ENOG4105D6A Electron transport complex G4278_11210 ENOG4108R3D Electron transport complex G4278_11220 ENOG4105M9B inner membrane protein ydgK G4278_11225 ENOG4105QZ5 OriC-binding nucleoid-associated protein G4278_11230 ENOG4106C6R beta-lactam resistance protein G4278_11235 ENOG4105D9R oxidoreductase G4278_11245 ENOG4105C87 Aminotransferase class I and II G4278_11250 ENOG4105CI1 PTS System G4278_11255 ENOG4107P2S Transcriptional regulator G4278_11260 ENOG4107ZQV short-chain dehydrogenase reductase G4278_11265 ENOG4105XEA Tetr family transcriptional regulator G4278_11270 ENOG4105CNT hydrolase family 2 G4278_11275 ENOG4105CT4 transporter G4278_11280 ENOG4108QNI outer membrane porin protein G4278_11285 ENOG4106J39 exported protein G4278_11290 ENOG4105EIP mannose-6-phosphate isomerase G4278_11295 ENOG4107GFK fumarate G4278_11300 ENOG4105C9Q fumarate hydratase class II G4278_11305 ENOG4105KR1 Trans-acting protein required for termination of DNA replication. Binds to DNA replication terminator sequences (terA to terF) to prevent the passage of replication forks. The termination efficiency will be affected by the affinity of this protein for the terminator sequence (By similarity) G4278_11310 ENOG4105JJR Histidine kinase G4278_11315 ENOG4107EXC regulatoR G4278_11320 ENOG4105RA2 Membrane G4278_11325 ENOG410642E Short chain dehydrogenase G4278_11330 ENOG4105D5Q Arginine ornithine antiporter G4278_11335 ENOG4105C5D exported protein G4278_11340 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) G4278_11345 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) G4278_11350 ENOG4105DSF transport protein G4278_11355 ENOG41090TI Catalyzes the excretion of spermidine (By similarity) G4278_11360 ENOG4108ZBZ Catalyzes the excretion of spermidine (By similarity) G4278_11365 ENOG4105CVW peptidase s1 and s6 chymotrypsin hap G4278_11380 ENOG4105D94 Major Facilitator Superfamily G4278_11385 ENOG4106NZI LysR family Transcriptional regulator G4278_11390 ENOG4105DAG ROK family G4278_11395 ENOG4105EWW Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) G4278_11405 ENOG4108NEM leader-binding protein dmsD G4278_11410 ENOG4107KGK dmso reductase anchor subunit G4278_11415 ENOG4105QAX Iron-sulfur G4278_11420 ENOG4105C3J Cysteine desulfurase G4278_11425 ENOG4107QY8 reductase G4278_11430 ENOG4105KBG Protein of unknown function (DUF1161) G4278_11440 ENOG4108MK9 spermidine N(1)-acetyltransferase G4278_11455 ENOG4105CXK mandelate racemase muconate lactonizing G4278_11460 ENOG4105CPQ Dehydrogenase G4278_11470 ENOG4105DEI Mannitol dehydrogenase G4278_11475 ENOG41061EV selenium-binding protein YdfZ G4278_11480 ENOG4107XBN GntR Family Transcriptional Regulator G4278_11485 ENOG4105EMU Dehydrogenase G4278_11490 ENOG4105DGW oligopeptidase A G4278_11495 ENOG4108YDI single-species biofilm formation on inanimate substrate G4278_11500 ENOG4105FSR swimming returnes to normal when residues 206-207 are both mutated to Ala. Overexpression also leads to a reduction in flagellar abundance and a 20-fold increase in c-di- GMP levels in vivo. Required for aminoglycoside-mediated induction of biofilm formation, it also plays a lesser role in biofilm production in response to other classes of translation inhibitors. The c-di-GMP produced by this enzyme up-regulates poly-GlcNAc production as well as the biofilm synthesis protein PgaD, although c-di-GMP is probably not the main inducing principle. Cyclic-di- GMP is a second messenger which controls cell surface-associated traits in bacteria G4278_11510 ENOG4105E5W Transporter G4278_11515 ENOG4108594 Permease of the drug metabolite transporter G4278_11520 ENOG4105FDP GntR family transcriptional regulator G4278_11530 ENOG4105CK1 PTS System G4278_11535 ENOG4105VCP PTS System G4278_11550 ENOG4106DNR multiple antibiotic resistance protein G4278_11555 ENOG4108XW0 May be a transcriptional activator of genes involved in the multiple antibiotic resistance (Mar) phenotype. It can also activate genes such as sodA, zwf and micF G4278_11560 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes G4278_11580 ENOG4105EGI Transcriptional regulator G4278_11585 ENOG4105C26 Dehydrogenase G4278_11590 ENOG4105CSV Glutaminase G4278_11595 ENOG4105M0C cytoplasmic protein G4278_11600 ENOG4105BZU Histidine kinase G4278_11610 ENOG4105FFC UPF0187 protein G4278_11615 ENOG4107R6G Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate (By similarity) G4278_11620 ENOG41061P8 Persistence to inhibition of murein or DNA biosynthesis regulatory protein G4278_11625 ENOG4105CAF HipA N-terminal domain protein G4278_11645 ENOG4108RQP Major type 1 subunit fimbrin G4278_11655 ENOG4105CW0 outer membrane usher protein G4278_11660 ENOG4108WDE Fimbrial protein G4278_11665 ENOG4106318 fimbrial-like protein YdeR G4278_11670 ENOG4106PIH fimbrial-like protein ydeQ G4278_11675 ENOG4107QKC Oxidoreductase alpha (molybdopterin) subunit G4278_11685 ENOG4108NKV transcriptional regulator G4278_11690 ENOG4105ENH Sulfatase G4278_11695 ENOG4105C4X radical SAM domain protein G4278_11705 ENOG4105CQ0 ABC transporter G4278_11710 ENOG4105PE1 Receptor G4278_11715 ENOG4107RAN Peptidase, M16 G4278_11720 ENOG4105CVK Glutamate decarboxylase G4278_11725 ENOG4105E5D amino acid G4278_11730 ENOG4105F32 YngK protein G4278_11735 ENOG4105BZU Histidine kinase G4278_11735 ENOG4105BZU Histidine kinase G4278_11740 ENOG4105BZU Histidine kinase G4278_11745 ENOG4108Z9K Osmotically inducible protein G4278_11750 ENOG4105TPS biofilm-dependent modulation protein G4278_11755 ENOG4107AV5 Although this protein associates with the 30S subunit of the ribosome it is not considered to be a bona fide ribosomal protein G4278_11760 ENOG4107R1I NAD-dependent malic enzyme G4278_11765 ENOG4105DQ4 alcohol dehydrogenase G4278_11775 ENOG41084S7 Plasmid maintenance system antidote protein G4278_11780 ENOG4108MG3 formate dehydrogenase G4278_11785 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein G4278_11795 ENOG4105RPH Inner membrane protein YddG G4278_11800 ENOG4107QND Nitrite extrusion protein G4278_11805 ENOG4105CRU nitrate reductase, alpha subunit G4278_11810 ENOG4108IUE nitrate reductase beta subunit G4278_11815 ENOG4108NZN Respiratory nitrate reductase 2 delta chain G4278_11820 ENOG4105D0D Nitrate reductase 2, gamma subunit G4278_11825 ENOG4105JAB phenazine biosynthesis protein, phzf family G4278_11830 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase G4278_11835 ENOG4108MEJ flavin reductase domain protein G4278_11865 ENOG4105CS6 Rhs element vgr protein G4278_11890 ENOG4105CS6 Rhs element vgr protein G4278_11905 ENOG4105C85 amino acid G4278_11910 ENOG4108NS2 receptor G4278_11915 ENOG4105CHB tonB-dependent Receptor G4278_11920 ENOG4108WYP Transcriptional regulator G4278_11930 ENOG4108Z7F N-acetyltransferase G4278_11935 ENOG4108T9Y Inner membrane protein ydcZ G4278_11940 ENOG4105R71 cytoplasmic protein G4278_11945 ENOG410654E Membrane G4278_11960 ENOG4105NRK Binding-protein-dependent transport systems, inner membrane component G4278_11965 ENOG4105D81 ABC transporter, permease G4278_11970 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) G4278_11975 ENOG4107TYH extracellular solute-binding protein family 1 G4278_11980 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family G4278_11990 ENOG4105RR0 Protein of unknown function (DUF2554) G4278_11995 ENOG4105CFP Peptidase U32 G4278_12000 ENOG4108JCI Transcriptional regulator G4278_12005 ENOG4105DKK Benzoate G4278_12010 ENOG4108KKZ (LipO)protein G4278_12015 ENOG41088CC tellurite resistance protein tehB G4278_12020 ENOG4108NKP c4-dicarboxylate transporter malic acid transport protein G4278_12025 ENOG4107WE3 acetyltransferase YdcK G4278_12030 ENOG4108Z9I -acetyltransferase G4278_12035 ENOG4105Z2P Protein of unknown function (DUF465) G4278_12045 ENOG4105E32 cytoplasmic protein G4278_12050 ENOG4105DDW LysR family Transcriptional regulator G4278_12060 ENOG4107NK6 Hok/gef family G4278_12065 ENOG4105UPP uncharacterized protein ydcA G4278_12070 ENOG4105CPW cytochrome b561 G4278_12075 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase G4278_12080 ENOG4105C26 Dehydrogenase G4278_12085 ENOG4107DB1 DUF218 domain G4278_12105 ENOG4105ZIA Phage protein gp16 G4278_12135 ENOG4105IKI host-nuclease inhibitor protein G4278_12225 ENOG4105CF2 Mu-like prophage FluMu protein GP28 G4278_12235 ENOG4108QUU Morphogenesis Protein G4278_12360 ENOG4108C33 Resolvase G4278_12370 ENOG4108V3G Catalyzes the reductive cleavage of azo bond in aromatic azo compounds to the corresponding amines. Requires NADH, but not NADPH, as an electron donor for its activity (By similarity) G4278_12375 ENOG41077RS Phosphatase G4278_12380 ENOG4105E8V Alpha Beta Hydrolase Fold protein G4278_12385 ENOG4108HPI phosphatidate Cytidylyltransferase G4278_12390 ENOG4108UMZ Cdp-alcohol phosphatidyltransferase G4278_12395 ENOG4107S5I aldo keto reductase G4278_12405 ENOG4105WXT Conserved Protein G4278_12410 ENOG410689M (LipO)protein G4278_12415 ENOG4107H52 Dicarboxylate transport G4278_12420 ENOG4105C5I Dehydrogenase G4278_12425 ENOG41090X5 Heat shock protein hslJ G4278_12430 ENOG4105IKK cytoplasmic protein G4278_12435 ENOG4105D95 Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity) G4278_12440 ENOG4105FCK Membrane G4278_12445 ENOG4108RW8 Universal stress protein F G4278_12470 ENOG4105C1J atp-dependent rna helicase G4278_12480 ENOG4105BZU Histidine kinase G4278_12485 ENOG4108DG9 Smr protein MutS2 G4278_12490 ENOG4105C0R drug resistance transporter emrb qaca subfamily G4278_12495 ENOG4105J12 Multidrug resistance protein mdtN G4278_12500 ENOG4105R1U AraC Family Transcriptional Regulator G4278_12510 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) G4278_12515 ENOG4105DS0 Transcriptional regulator, Crp Fnr family G4278_12520 ENOG4105Q9Y Universal stress protein G4278_12525 ENOG4105S5I Membrane G4278_12530 ENOG4105D64 Mechanosensitive ion channel G4278_12535 ENOG4107QSI ABC, transporter G4278_12540 ENOG4105EQ2 LysR family Transcriptional regulator G4278_12545 ENOG4105ENX hydrolase G4278_12565 ENOG4107S8C mandelate racemase muconate lactonizing G4278_12570 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) G4278_12575 ENOG4108JU8 Transcriptional regulator G4278_12585 ENOG4105CM6 amino acid regulated cytosolic protein G4278_12590 ENOG4105FKQ transcriptional regulator G4278_12595 ENOG4107EFV Outer membrane protein G G4278_12600 ENOG4108IJ9 (ABC) transporter G4278_12605 ENOG4107URF beta-phospho-glucomutase G4278_12610 ENOG4105C71 hydrolase family 65, central catalytic G4278_12615 ENOG4105CK5 oxidoreductase G4278_12620 ENOG4107TYA transient receptor potential locus G4278_12625 ENOG4107RRD Dehydrogenase G4278_12630 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component G4278_12635 ENOG4105HS6 binding-protein-dependent transport systems inner membrane Component G4278_12640 ENOG4105WEM extracellular solute-binding protein G4278_12645 ENOG4107QW3 Sucrose phosphorylase G4278_12650 ENOG4105K8Z Phage shock protein G4278_12655 ENOG4105NNG Peripheral inner membrane phage-shock protein G4278_12660 ENOG4105FM1 phage shock protein C G4278_12665 ENOG4105YYT phage shock protein B G4278_12670 ENOG41087YS Phage shock protein A G4278_12675 ENOG4105E51 psp operon transcriptional activator G4278_12685 ENOG4105N0E Protein of unknown function (DUF2543) G4278_12690 ENOG4108HIY periplasmic G4278_12695 ENOG4108I5W peptide transport system, permease protein G4278_12700 ENOG4108EU3 peptide transport system, permease G4278_12705 ENOG4108JQ3 Peptide ABC transporter ATP-binding protein G4278_12710 ENOG4108JQ2 peptide transport system atp-binding protein G4278_12715 ENOG4105C2C drug resistance transporter, Bcr CflA G4278_12720 ENOG4105ENJ RND efflux system, outer membrane lipoprotein G4278_12730 ENOG4105C1P efflux transporter, rnd family, mfp subunit G4278_12735 ENOG41067SE Tetr family transcriptional regulator G4278_12740 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH G4278_12745 ENOG4105Q4T oxidoreductase G4278_12750 ENOG4108IEC Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction (By similarity) G4278_12760 ENOG4105BZU Histidine kinase G4278_12765 ENOG410643D UPF0509 protein G4278_12770 ENOG4105N2W Transcriptional regulator G4278_12780 ENOG4108ZJT translation initiation factor, Sui1 G4278_12790 ENOG4105CFV Tetratricopeptide repeat protein G4278_12795 ENOG4105Q4A inner membrane protein yciS G4278_12800 ENOG4105EYK Phosphatidylglycerophosphatase B G4278_12810 ENOG4107QM5 aconitate hydratase G4278_12830 ENOG4107R11 Transcriptional regulator G4278_12835 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) G4278_12840 ENOG4105RKX Protein of unknown function (DUF2498) G4278_12845 ENOG4105ERU peptidase G4278_12850 ENOG4105UBK short-chain dehydrogenase reductase G4278_12855 ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase G4278_12860 ENOG4105FE9 pseudouridine synthase G4278_12865 ENOG4105EG3 transmembrane signal peptide protein G4278_12870 ENOG4107RTD sua5 ycio yrdc ywlc family protein G4278_12875 ENOG4105DB7 PHP domain protein G4278_12885 ENOG4105CRQ synthase (Component I) G4278_12890 ENOG4108EFP Anthranilate synthase component II G4278_12895 ENOG4105DK0 Indole-3-glycerol phosphate synthase G4278_12905 ENOG4105F6H The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate (By similarity) G4278_12910 ENOG4108Z9Z response to DNA damage stimulus G4278_12915 ENOG4108N8X transition metal ion binding G4278_12920 ENOG4105EIF outer membrane protein W G4278_12930 ENOG4108S3I UPF0259 membrane protein G4278_12940 ENOG4105NAU thioesterase Superfamily protein G4278_12945 ENOG410822N TonB family G4278_12950 ENOG4105K9H YciI-like protein G4278_12955 ENOG4107SVH Potassium channel protein G4278_12975 ENOG4108JQ7 (ABC) transporter G4278_12980 ENOG4105C3U ABC transporter G4278_12985 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component G4278_12990 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component G4278_12995 ENOG4108J59 Extracellular solute-binding protein, family 5 G4278_13005 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein G4278_13010 ENOG4105C0A alcohol dehydrogenase G4278_13020 ENOG4107104 thymidine kinase G4278_13025 ENOG4108SAU DNA-binding protein H-ns G4278_13030 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase G4278_13035 ENOG4105I93 response regulator G4278_13040 ENOG4105D78 K07001 NTE family protein G4278_13050 ENOG4105CIY formyltetrahydrofolate deformylase G4278_13095 ENOG4107VBM 3-beta hydroxysteroid dehydrogenase isomerase G4278_13100 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) G4278_13105 ENOG41076YT nitrate reductase, gamma subunit G4278_13110 ENOG4105R3A Nitrate reductase G4278_13115 ENOG4108IUE nitrate reductase beta subunit G4278_13120 ENOG4105CRU nitrate reductase, alpha subunit G4278_13125 ENOG4105DQQ Major facilitator superfamily MFS_1 G4278_13130 ENOG4105BZU Histidine kinase G4278_13135 ENOG4105WH1 Two component transcriptional regulator luxr family G4278_13140 ENOG4105ID0 Putative invasin G4278_13145 ENOG41090EX DsrE family G4278_13150 ENOG4108NH8 Cation transport protein G4278_13155 ENOG4105WS7 Cation transport regulator G4278_13160 ENOG4105EWV Sodium calcium exchanger membrane region G4278_13175 ENOG41063JG Transcriptional regulator G4278_13180 ENOG4108YY7 Invasion gene expression up-regulator SirB G4278_13185 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) G4278_13200 ENOG4105C1U Plays a critical role in the incorporation of lipoproteins in the outer membrane after they are released by the LolA protein (By similarity) G4278_13205 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) G4278_13210 ENOG4105C5T Phosphoribosyl pyrophosphate synthase G4278_13215 ENOG4105CHH sulfate transporter G4278_13220 ENOG4105MGX transcription activated by CRP (cyclic AMP receptor protein), a global transcription factor involved in regulation of metabolism in enteric bacteria G4278_13230 ENOG4105C3G gtp-binding protein G4278_13240 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family G4278_13245 ENOG4105CMT Dihydroxyacetone kinase G4278_13250 ENOG4108UTZ Dihydroxyacetone kinase G4278_13255 ENOG4105VDH Dihydroxyacetone kinase G4278_13260 ENOG4105E53 ec 3.2.1.28 G4278_13270 ENOG4105S10 periplasmic binding protein G4278_13275 ENOG4105EHG Permease protein G4278_13280 ENOG4105E0A ABC, transporter G4278_13285 ENOG4108BSC Methyltransferase G4278_13290 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase G4278_13305 ENOG4108T7K Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Increasing levels of c-di-GMP lead to decreased motility (By similarity) G4278_13315 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A G4278_13325 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) G4278_13335 ENOG4105ED1 spovr family G4278_13345 ENOG4105DKR Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) G4278_13355 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) G4278_13360 ENOG4105KT5 UmuD protein G4278_13365 ENOG4106PXS Toxin, which has some hemolytic activity towards mammalian cells. Acts by forming a pore-like structure upon contact with mammalian cells G4278_13370 ENOG4108ZZ3 UPF0260 protein G4278_13375 ENOG4105FBJ fumarylacetoacetate (faa) hydrolase G4278_13385 ENOG41066UD Inhibits activity of g-type lysozyme, which confers increased lysozyme tolerance to the bacterium G4278_13390 ENOG4105S66 prophage protein G4278_13395 ENOG4105K7U Cell division inhibitor that blocks the formation of polar Z ring septums. Rapidly oscillates between the poles of the cell to destabilize FtsZ filaments that have formed before they mature into polar Z rings. Prevents FtsZ polymerization (By similarity) G4278_13400 ENOG4107QMS site-determining protein G4278_13435 ENOG410658X G4278_13455 ENOG4105BZU Histidine kinase G4278_13475 ENOG4105DIK (ABC) transporter G4278_13480 ENOG4105CC5 ABC transporter G4278_13485 ENOG4105CC5 ABC transporter G4278_13500 ENOG4108X9F tail fiber protein G4278_13570 ENOG4105IM0 capsid protein G4278_13595 ENOG4105UZW Tail fiber assembly protein G4278_13615 ENOG4105QYK bacteriophage lambda Bor protein homolog G4278_13625 ENOG4105KUS lysozyme G4278_13630 ENOG4105QFS Lysis protein S homolog from lambdoid prophage G4278_13640 ENOG4105HRS Antitermination protein G4278_13680 ENOG4105NY2 NinB protein G4278_13835 ENOG4108I1J Integrase G4278_13840 ENOG4108HMX isocitrate dehydrogenase (NADP) G4278_13865 ENOG4107QTF adenylosuccinate lyase G4278_13870 ENOG4105XJC Two component transcriptional regulator (Winged helix family G4278_13875 ENOG4105IFJ Histidine kinase G4278_13880 ENOG4105EZE Cupin 4 family protein G4278_13890 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) G4278_13905 ENOG4108WF3 methyltransferase G4278_13910 ENOG4105UZW Tail fiber assembly protein G4278_13925 ENOG4108X9F tail fiber protein G4278_14000 ENOG4105IM0 capsid protein G4278_14025 ENOG4105UZW Tail fiber assembly protein G4278_14035 ENOG4106YSC G4278_14040 ENOG41064WM Uncharacterized protein YcgX G4278_14045 ENOG4106050 phage regulatory protein, rha family G4278_14075 ENOG4105QFS Lysis protein S homolog from lambdoid prophage G4278_14115 ENOG4105HGD Antitermination protein G4278_14120 ENOG4105KSK (crossover) junction endodeoxyribonuclease G4278_14125 ENOG4108MXB Protein of unknown function (DUF968) G4278_14160 ENOG4108PM0 it is also involved in inducing stable DNA replication during SOS response. It forms, in concert with DnaB protein and other prepriming proteins DnaC, N, N', N'' a prepriming protein complex on the specific site of the template DNA recognized by protein N' (By similarity) G4278_14200 ENOG4106G8A Qin prophage G4278_14205 ENOG41076J9 exonuclease VIII G4278_14215 ENOG4108I1J Integrase G4278_14220 ENOG4105D38 putrescine abc transporter G4278_14225 ENOG4107RUE extracellular solute-binding protein family 1 G4278_14240 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) G4278_14245 ENOG4105EZX Catalyzes the phosphorylation of N-acetyl-D-glucosamine (GlcNAc) derived from cell-wall degradation, yielding GlcNAc-6-P (By similarity) G4278_14250 ENOG4105D60 lipoprotein releasing system transmembrane protein G4278_14255 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) G4278_14260 ENOG4105D60 lipoprotein releasing system transmembrane protein G4278_14265 ENOG4105IQC Inner membrane protein YcfT G4278_14270 ENOG4108JA2 transcriptioN-repair coupling factor G4278_14275 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein G4278_14280 ENOG4105RC8 Reduces the permeability of the outer membrane to copper. Seems to be involved in the regulation of biofilm formation. May decrease biofilm formation by repressing cell-cell interaction and cell surface interaction G4278_14285 ENOG4108IND Tetr family transcriptional regulator G4278_14290 ENOG4107MBR 17 kDa surface antigen G4278_14295 ENOG4105CEP NADH dehydrogenase G4278_14305 ENOG4107QPA Cleaves GlcNAc linked beta-1,4 to MurNAc tripeptides (By similarity) G4278_14310 ENOG4108RUM thiamine kinase G4278_14315 ENOG4108WEF Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b) (By similarity) G4278_14320 ENOG41090DQ Lipoprotein G4278_14325 ENOG4105K59 histidine triad (HIT) protein G4278_14335 ENOG4105CI1 PTS System G4278_14340 ENOG4105F8V Hydrolase, tatD family G4278_14345 ENOG4107QRG dna polymerase iii G4278_14350 ENOG4108ZMD Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity) G4278_14355 ENOG4105HHA aminodeoxychorismate lyase G4278_14360 ENOG4105YAZ 4-amino-4-deoxychorismate lyase G4278_14365 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) G4278_14370 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) G4278_14375 ENOG4105CHR reductase G4278_14380 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase G4278_14400 ENOG4105FCQ metal-binding, possibly nucleic acid-binding protein G4278_14405 ENOG4108UHJ MAF-like protein G4278_14410 ENOG4105EI2 Pseudouridine synthase G4278_14415 ENOG4107QQB Ribonuclease E G4278_14420 ENOG4105DTJ flagellar hook-associated protein G4278_14425 ENOG4105E1Q flagellar hook-associated protein G4278_14430 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj G4278_14435 ENOG4105D92 Assembles around the rod to form the L-ring and probably protects the motor basal body from shearing forces during rotation (By similarity) G4278_14445 ENOG4105CGA flagellar basal-body rod protein FlgG G4278_14450 ENOG4108KPB Flagellar basal-body rod protein FlgF G4278_14460 ENOG4108ZC9 flagellar basal-body rod protein flgc G4278_14465 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) G4278_14470 ENOG4105CKS Flagella basal body P-ring formation protein flgA G4278_14475 ENOG4105M9M anti-sigma28 factor FlgM G4278_14480 ENOG4105QVD Flagella synthesis protein FlgN G4278_14485 ENOG4105CJR Integral membrane protein (MviN G4278_14490 ENOG4105EP9 oxidoreductase G4278_14500 ENOG4105D9U N-acetyltransferase G4278_14510 ENOG4105E9S glutaredoxin 2 G4278_14515 ENOG4105F3T (LipO)protein G4278_14520 ENOG4105EKE dihydroorotase G4278_14525 ENOG4105MEA DNA damage-inducible protein i G4278_14530 ENOG4105PVA Biofilm formation regulatory protein BssS G4278_14535 ENOG4105F76 Sarcosine oxidase G4278_14540 ENOG4106974 biofilm formation G4278_14545 ENOG4105DS1 cytochrome b561 G4278_14550 ENOG4108YYC ycei family G4278_14555 ENOG4105C72 UPF0176 protein G4278_14560 ENOG4105D1S lipid A biosynthesis G4278_14565 ENOG4105C6X Major Facilitator G4278_14570 ENOG4108W47 Acidic protein msyB G4278_14575 ENOG4105NAC (LipO)protein G4278_14580 ENOG4105C3A Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs) (By similarity) G4278_14595 ENOG4107RZC phospholipase d G4278_14600 ENOG4108UVJ appr-1-p processing domain protein G4278_14615 ENOG41090QH cryptic curlin major subunit G4278_14620 ENOG4108U0V Curli are coiled surface structures that assemble preferentially at growth temperatures below 37 degrees Celsius. Curli can bind to fibronectin. The minor subunit is the nucleation component of curlin monomers G4278_14625 ENOG41086KC Transcriptional regulator G4278_14630 ENOG4108XDW curli assembly protein CsgE G4278_14635 ENOG4108WYR Curli production assembly transport component, CsgF G4278_14640 ENOG4105P8Q Curli production assembly transport component CsgG G4278_14645 ENOG4108UQ5 membrane protein YcdZ G4278_14650 ENOG4107XHZ cytoplasmic chaperone TorD family protein G4278_14660 ENOG4105JPG D-isomer specific 2-hydroxyacid dehydrogenase G4278_14670 ENOG4105BZU Histidine kinase G4278_14675 ENOG4108TUY outer membrane protein PgaA G4278_14680 ENOG4107BJW polysaccharide deacetylase G4278_14685 ENOG4105CND Glycosyl transferase, family 2 G4278_14695 ENOG4105D5M phosphate starvation-inducible protein G4278_14705 ENOG410650H (LipO)protein G4278_14715 ENOG4105CK7 Sodium proline symporter G4278_14725 ENOG4105C26 Dehydrogenase G4278_14730 ENOG4108R86 Transcriptional regulator G4278_14735 ENOG4105EQP Catalyzes the pyrimidine ring opening between N-3 and C- 4 by an unusual flavin hydroperoxide-catalyzed mechanism to yield ureidoacrylate peracid. It cleaves pyrmidine rings directly by adding oxygen atoms, making a toxic ureidoacrylate peracid product which can be spontaneously reduced to ureidoacrylate (By similarity) G4278_14740 ENOG4106XMA In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2 (By similarity) G4278_14750 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) G4278_14755 ENOG4108RDT NADH dehydrogenase NAD(P)H nitroreductase) G4278_14760 ENOG4107YAQ Catalyzes the reduction of FMN to FMNH2 which is used to reduce pyrimidine by RutA via the Rut pathway (By similarity) G4278_14765 ENOG4105C2W permease G4278_14770 ENOG4105XF5 Escherichia coli IMT2125 genomic chromosome, IMT2125 G4278_14780 ENOG4105XH3 G4278_14785 ENOG4105D6F Phosphatase G4278_14800 ENOG4108SBI Involved in the biogenesis of TorA. Acts on TorA before the insertion of the molybdenum cofactor and, as a result, probably favors a conformation of the apoenzyme that is competent for acquiring the cofactor (By similarity) G4278_14805 ENOG4108EM1 reductase G4278_14810 ENOG4105CUW cytochrome C-TYPE protein G4278_14815 ENOG4106WF9 DNA-binding transcriptional regulator TorR G4278_14820 ENOG4108SV3 Tmao reductase system periplasmic protein tort G4278_14825 ENOG4105BZU Histidine kinase G4278_14830 ENOG4105HEE Binding Domain protein G4278_14835 ENOG4106H71 Overexpression increases levels of unsaturated fatty acids and suppresses both the temperature-sensitive fabA6 mutation and cold-sensitive secG null mutation G4278_14850 ENOG4105VEQ Cold shock protein G4278_14855 ENOG41060EU Cold shock-like protein G4278_14860 ENOG4105D6F Phosphatase G4278_14870 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii G4278_14875 ENOG4105C4M (Ubiquinol oxidase) subunit I G4278_14880 ENOG4105MVP hydrogenase-1 operon protein HyaF G4278_14885 ENOG4108VXY Hydrogenase-1 operon protein HyaE G4278_14890 ENOG4108USZ hydrogenase G4278_14895 ENOG4105X7T Ni Fe-hydrogenase, b-type cytochrome subunit G4278_14900 ENOG4105DPX Hydrogenase, large subunit G4278_14905 ENOG4105E3S small subunit G4278_14915 ENOG4108MN8 Membrane G4278_14920 ENOG4108Z0T Part of a sulfur-relay system (By similarity) G4278_14925 ENOG4105VSY K01512 acylphosphatase EC 3.6.1.7 G4278_14940 ENOG4105K4P CoA-binding domain protein G4278_14955 ENOG41088T4 Helicase IV G4278_14960 ENOG410901E Membrane G4278_14965 ENOG4105EM2 membrane G4278_14970 ENOG4108RZ1 DNA transformation protein G4278_14980 ENOG4105UYK outer membrane protein a G4278_14990 ENOG4105DAN ATP-dependent protease G4278_15000 ENOG4105WFT During stationary phase, converts 70S ribosomes to an inactive dimeric form (100S ribosomes) (By similarity) G4278_15005 ENOG4108Q2G (LipO)protein G4278_15010 ENOG4105DY2 Paraquat-inducible protein b G4278_15015 ENOG4105F1S paraquat-inducible protein a G4278_15020 ENOG4105C5H ABC transporter G4278_15025 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) G4278_15030 ENOG4105QVC MOSC domain-containing protein G4278_15035 ENOG4108T7E Contributes to the efficiency of the cell division process by stabilizing the polymeric form of the cell division protein FtsZ. Acts by promoting interactions between FtsZ protofilaments and suppressing the GTPase activity of FtsZ (By similarity) G4278_15045 ENOG4108UZX fmn reductase G4278_15050 ENOG4105GVF (ABC) transporter G4278_15060 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component G4278_15065 ENOG4105E2Y ABC, transporter G4278_15070 ENOG4105CD8 aminopeptidase N G4278_15090 ENOG4105CGF Aromatic amino acid aminotransferase G4278_15095 ENOG4105C5X domain protein G4278_15100 ENOG4105EAQ (twin-arginine translocation) pathway signal G4278_15105 ENOG4105DIT ErfK YbiS YcfS YnhG family protein G4278_15110 ENOG4105DUC Plays a central role in chromosome condensation, segregation and cell cycle progression. Functions as a homodimer, which is essential for chromosome partition. Involved in negative DNA supercoiling in vivo, and by this means organize and compact chromosomes. May achieve or facilitate chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division (By similarity) G4278_15115 ENOG4105DAH Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF (By similarity) G4278_15125 ENOG4106371 Methyltransferase G4278_15130 ENOG4107S90 membrAne G4278_15135 ENOG4107VR7 transferase activity, transferring phosphorus-containing groups G4278_15140 ENOG4105CET Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity) G4278_15150 ENOG4105T0Z Conserved Protein G4278_15160 ENOG4105BZ1 (ABC) transporter G4278_15165 ENOG4108EQH DNA internalization-related competence protein ComEC Rec2 G4278_15175 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) G4278_15185 ENOG4108K0D peptidase, M48 G4278_15190 ENOG4105CMY 5-enolpyruvylshikimate-3-phosphate synthase G4278_15200 ENOG4107VMU Membrane G4278_15205 ENOG4105DDY UPF0142 protein ycaO G4278_15210 ENOG4105TMB Formate nitrite transporter G4278_15215 ENOG4105C6N Formate acetyltransferase G4278_15220 ENOG4105F1A Pyruvate formate-lyase G4278_15230 ENOG4105CHJ isochorismatase hydrolase G4278_15235 ENOG4107KGK dmso reductase anchor subunit G4278_15240 ENOG4105QAX Iron-sulfur G4278_15245 ENOG4107QY8 reductase G4278_15255 ENOG4105D1H recombination factor protein RarA G4278_15265 ENOG4105CNU cell division protein FtsK G4278_15275 ENOG4105C3M thioredoxin reductase G4278_15280 ENOG4108JJ9 ABC, transporter G4278_15285 ENOG4108JJ8 (ABC) transporter G4278_15295 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) G4278_15305 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit G4278_15315 ENOG4105VEQ Cold shock protein G4278_15325 ENOG4105DJY efflux transporter, rnd family, mfp subunit G4278_15330 ENOG4108MJ5 VirK protein G4278_15335 ENOG4105CPB ATP-dependent endonuclease of the OLD family G4278_15340 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) G4278_15345 ENOG4105DWU Membrane G4278_15350 ENOG4105EJ7 Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O (By similarity) G4278_15355 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) G4278_15360 ENOG4105C7K acetolactate synthase G4278_15365 ENOG4105C5W Aldolase G4278_15370 ENOG4105CGD Nad-dependent epimerase dehydratase G4278_15375 ENOG4107VBM 3-beta hydroxysteroid dehydrogenase isomerase G4278_15380 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase G4278_15390 ENOG41064MM (LipO)protein G4278_15395 ENOG4105E5Z arginine transporter ATP-binding subunit G4278_15400 ENOG4106PMH Extracellular solute-binding protein family 3 G4278_15405 ENOG4105GBT ABC transporter G4278_15410 ENOG4105DMR ABC, transporter G4278_15415 ENOG4106TNF Periplasmic binding protein G4278_15420 ENOG4107SFS Catalyzes the formation of 5-methyl-uridine at position 747 (m5U747) in 23S rRNA (By similarity) G4278_15425 ENOG4105RBQ inner membrane protein ybjO G4278_15430 ENOG4105D38 putrescine abc transporter G4278_15435 ENOG4105F38 ABC transporter, permease G4278_15440 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) G4278_15445 ENOG4107RUE extracellular solute-binding protein family 1 G4278_15450 ENOG4108RMJ sensory transduction regulator G4278_15460 ENOG4108DBC nitroreductase G4278_15465 ENOG4105X20 member of the soxRS regulon which mediates in part the increased levels of superoxide in response to oxidative stress G4278_15470 ENOG41090BQ Glutaredoxin G4278_15475 ENOG4105GWF inner membrane protein YbjM G4278_15485 ENOG4108RFG Tetr family transcriptional regulator G4278_15490 ENOG4106UW1 Major Facilitator superfamily G4278_15495 ENOG4108HCJ Hydrolase G4278_15505 ENOG4107QF7 multi-drug G4278_15510 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase G4278_15515 ENOG4107FB0 transcriptional regulator DeoR family G4278_15520 ENOG4105DZ1 carboxypeptidase G4278_15525 ENOG4108TGY Glutathione S-transferase G4278_15530 ENOG4105D8V Glucose sorbosone dehydrogenase G4278_15535 ENOG4105UFT Represses biofilm formation in M9C glu and LB glu media but not in M9C and LB media. Seems to act as a global regulator of several genes involved in catabolite repression and stress response and regulation of the uptake and export of signaling pathways. Could be involved the regulation of indole as well as uptake and export of AI-2 through a cAMP-dependent pathway G4278_15545 ENOG41064RH membrane protein YliF G4278_15550 ENOG4105BZU Histidine kinase G4278_15555 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component G4278_15570 ENOG4108JQ6 ABC transporter G4278_15575 ENOG4105D44 asparaginase G4278_15580 ENOG4105CVM Molybdenum cofactor synthesis domain protein G4278_15585 ENOG4105D06 uba thif-type nad fad binding protein G4278_15590 ENOG4107T9Z Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) G4278_15595 ENOG4105F1A Pyruvate formate-lyase G4278_15605 ENOG4108HCJ Hydrolase G4278_15610 ENOG4105C5H ABC transporter G4278_15615 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein G4278_15620 ENOG4105F4P )-transporter G4278_15625 ENOG4105KST dependent repressor G4278_15635 ENOG4108I6E Sulfatase G4278_15640 ENOG4108T1M outer membrane protein x G4278_15650 ENOG4107AQZ Membrane G4278_15655 ENOG4105DPV During stationary phase, binds the chromosome non- specifically, forming a highly ordered and stable dps-DNA co- crystal within which chromosomal DNA is condensed and protected from diverse damages. It protects DNA from oxidative damage by sequestering intracellular Fe(2 ) ion and storing it in the form of Fe(3 ) oxyhydroxide mineral, which can be released after reduction. One hydrogen peroxide oxidizes two Fe(2 ) ions, which prevents hydroxyl radical production by the Fenton reaction G4278_15660 ENOG4107R0W ABC transporter G4278_15665 ENOG4105E5Q amino acid AbC transporter G4278_15670 ENOG4105CDA abc transporter atp-binding protein G4278_15675 ENOG4105D8X mechanosensitive ion channel G4278_15680 ENOG4105EBA Specifically methylates the adenine in position 1618 of 23S rRNA (By similarity) G4278_15685 ENOG4105ZY9 UPF0379 protein ybiM G4278_15695 ENOG4107E2E PKHD-type hydroxylase G4278_15700 ENOG4105KSC Transcriptional regulator, TraR DksA family G4278_15705 ENOG4105VR4 UPF0379 protein ybiJ G4278_15710 ENOG4105DG4 malate L-lactate dehydrogenase G4278_15715 ENOG4108MTB glycosyl transferase family G4278_15720 ENOG4105DVT helicase G4278_15730 ENOG4105C1J atp-dependent rna helicase G4278_15735 ENOG4107MVR Transcriptional regulator G4278_15740 ENOG4105D0S secretion protein (HlyD G4278_15745 ENOG4105CJ1 ABC, transporter G4278_15750 ENOG4107QWP ABC-2 type transporter G4278_15755 ENOG4107QWP ABC-2 type transporter G4278_15760 ENOG4105I9U inner membrane protein ybhQ G4278_15765 ENOG4105X23 Endonuclease Exonuclease phosphatase G4278_15770 ENOG4105DZQ phospholipase D Transphosphatidylase G4278_15775 ENOG4107UXM Membrane G4278_15780 ENOG410733J conserved inner membrane protein G4278_15785 ENOG4105HFZ Membrane G4278_15790 ENOG4108ZAF Molybdopterin G4278_15795 ENOG4105M00 molybdopterin converting factor, subunit 1 G4278_15805 ENOG4108RIR Molybdenum cofactor biosynthesis protein G4278_15815 ENOG4105CHW UPF0052 protein G4278_15825 ENOG4105E78 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) G4278_15830 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) G4278_15835 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) G4278_15845 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) G4278_15850 ENOG4105D7V transposase G4278_15855 ENOG4108V1U phospholipid-binding protein G4278_15860 ENOG4105NBR Pectinesterase G4278_15865 ENOG4107QM5 aconitate hydratase G4278_15870 ENOG4107QPK )-transporter G4278_15875 ENOG4105C7F AcnD-accessory protein PrpF G4278_15880 ENOG4105F04 LysR family Transcriptional regulator G4278_15885 ENOG4105HHQ 6-phosphogluconolactonase (EC 3.1.1.31) G4278_15890 ENOG4108K4B hydrolase G4278_15895 ENOG4105CGB Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system (By similarity) G4278_15900 ENOG4105E0C molybdate abc transporter G4278_15905 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein G4278_15915 ENOG4105F4R Transcriptional regulator mode G4278_15920 ENOG4105DKW ABC transporter G4278_15925 ENOG4105CMR udp-glucose 4-epimerase G4278_15930 ENOG4105F0Z galactose-1-phosphate uridylyltransferase G4278_15940 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) G4278_15950 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) G4278_15955 ENOG4105JND homeobox protein G4278_15965 ENOG4106Z1T Nicotinamide Mononucleotide Transporter G4278_15970 ENOG4105D0I Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate (By similarity) G4278_16005 ENOG4105UFD tol-pal system protein YbgF G4278_16010 ENOG4105KCK Peptidoglycan-associated lipoprotein G4278_16020 ENOG4108Z82 Cell envelope integrity inner membrane protein TolA G4278_16030 ENOG4105E02 MotA TolQ exbB proton channel G4278_16035 ENOG4107YD3 Thioesterase G4278_16040 ENOG4105KJB cyd operon protein YbgE G4278_16050 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii G4278_16055 ENOG4105C4M (Ubiquinol oxidase) subunit I G4278_16065 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha G4278_16075 ENOG4105C7S Dehydrogenase G4278_16080 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 G4278_16085 ENOG4105E33 succinate dehydrogenase G4278_16090 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) G4278_16095 ENOG4105N1I succinate dehydrogenase, hydrophobic membrane anchor protein G4278_16100 ENOG4108UTY succinate dehydrogenase, cytochrome b556 subunit G4278_16110 ENOG4105BZN citrate synthase G4278_16120 ENOG4108KK1 membrane protein AbrB duplication G4278_16125 ENOG4108S0J Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized pyrimidines, such as thymine glycol, 5,6-dihydrouracil and 5,6-dihydrothymine. Has AP (apurinic apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'- phosphates (By similarity) G4278_16130 ENOG4105E7W lamb ycsf family protein G4278_16135 ENOG4107R7A Allophanate hydrolase subunit 2 G4278_16140 ENOG4105P4J Allophanate hydrolase, subunit 1 G4278_16145 ENOG4107QNR UPF0135 protein G4278_16150 ENOG4105DUX Transporter G4278_16155 ENOG4105CVP deoxyribo-dipyrimidine photolyase G4278_16160 ENOG4107SEY Conserved Protein G4278_16165 ENOG4105XIQ Protein of unknown function (DUF2517) G4278_16175 ENOG4105D9K One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions (By similarity) G4278_16185 ENOG4108R80 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex (By similarity) G4278_16190 ENOG4105C08 Histidine kinase G4278_16195 ENOG4105EEX Two component transcriptional regulator (Winged helix family G4278_16205 ENOG4105CXN decarboxylase G4278_16210 ENOG4105D5Q Arginine ornithine antiporter G4278_16215 ENOG4107QIX Phosphoglucomutase (EC 5.4.2.2 G4278_16220 ENOG4107CDU Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated (By similarity) G4278_16225 ENOG4105EV9 Alpha Beta Hydrolase G4278_16230 ENOG4105NNH LexA regulated protein G4278_16235 ENOG4105MHQ Low-potential electron donor to a number of redox enzymes (By similarity) G4278_16245 ENOG41090R7 Ferric uptake G4278_16250 ENOG4105GX6 (LipO)protein G4278_16265 ENOG4105MVE transcriptional regulator G4278_16270 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) G4278_16275 ENOG4107S2N Type III effector Hrp-dependent G4278_16280 ENOG4108JB8 alcohol dehydrogenase G4278_16285 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) G4278_16290 ENOG4105EE5 Membrane protein terC G4278_16310 ENOG4105CI1 PTS System G4278_16315 ENOG4105CKA Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion (By similarity) G4278_16320 ENOG4105CE4 GlcNAc 6-P deacetylase G4278_16325 ENOG4105E2R ROK family G4278_16330 ENOG4105D4U had-superfamily hydrolase, subfamily iia G4278_16335 ENOG4105CAQ asparagine synthetase G4278_16375 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family G4278_16385 ENOG4105C9A Phoh family G4278_16395 ENOG4108JU5 Magnesium and cobalt efflux protein G4278_16400 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) G4278_16405 ENOG4107U91 Rhomboid family G4278_16410 ENOG4107RP9 extracellular solute-binding protein, family 3 G4278_16415 ENOG4105EAD ABC transporter G4278_16420 ENOG4105DRP amino acid AbC transporter G4278_16425 ENOG4105CDA abc transporter atp-binding protein G4278_16435 ENOG4107PAI alpha helical protein G4278_16450 ENOG4105DJF DNA polymerase III, delta' subunit G4278_16460 ENOG4108TGR phosphatase G4278_16465 ENOG4105KEM Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) G4278_16475 ENOG4105CJN penicillin-binding protein G4278_16480 ENOG4105CNI cell division protein FtsW G4278_16485 ENOG4105K6T rare lipoprotein A G4278_16490 ENOG4105DZ1 carboxypeptidase G4278_16510 ENOG410607N Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatE shares overlapping functions with TatA (By similarity) G4278_16530 ENOG41079UR PagP is required both for biosynthesis of hepta-acylated lipid A species containing palmitate and for resistance to cationic antimicrobial peptides (CAMPs). It catalyzes the transfer of a palmitate chain (16 0) from the sn-1 position of a glycerophospholipid to the free hydroxyl group of the (R)-3- hydroxymyristate chain at position 2 of lipid A (endotoxin) (By similarity) G4278_16535 ENOG4105CEE C4-dicarboxylate transporter G4278_16540 ENOG4106YYS transcriptional regulatory protein G4278_16545 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism G4278_16550 ENOG4105DUA (citrate (pro-3S)-lyase ligase G4278_16560 ENOG4105CI0 Citrate lyase G4278_16565 ENOG4105CHY citrate lyase, alpha G4278_16580 ENOG4107QPK )-transporter G4278_16585 ENOG4105KTS ribonuclease G4278_16590 ENOG4105NXH GreA GreB family elongation factor G4278_16595 ENOG4108U51 Universal stress protein G4278_16600 ENOG4108JU3 Alkyl hydroperoxide reductase G4278_16605 ENOG4105D3R alkyl hydroperoxide reductase G4278_16610 ENOG4108KHN disulfide isomerase, thiol-disulfide oxidase G4278_16615 ENOG4105DQS Transcriptional regulator G4278_16620 ENOG4105BZV Phosphoadenosine phosphosulfate reductase G4278_16625 ENOG4105GTN ParB Domain Protein Nuclease G4278_16630 ENOG4105CHM Aminotransferase G4278_16635 ENOG4107SCQ Iron-containing alcohol dehydrogenase G4278_16640 ENOG4105VCD cytoplasmic protein G4278_16645 ENOG4105D22 carbon starvation protein G4278_16650 ENOG4108TZA Required for optimal enterobactin synthesis. Acts as a proofreading enzyme that prevents EntB misacylation by hydrolyzing the thioester bound existing between EntB and wrongly charged molecules (By similarity) G4278_16655 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase G4278_16660 ENOG4105WQI isochorismatase G4278_16665 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase G4278_16670 ENOG4105E4F Isochorismate synthase G4278_16675 ENOG4105PEC Iron-enterobactin transporter periplasmic binding protein G4278_16685 ENOG4105DQ5 transport system permease protein G4278_16690 ENOG4105TVJ transport system, permease G4278_16695 ENOG4105E0A ABC, transporter G4278_16700 ENOG4108QY5 Ferric enterobactin transport protein G4278_16705 ENOG4105C0W non-ribosomal peptide synthetase G4278_16710 ENOG41085A6 mbth domain-containing protein G4278_16715 ENOG4105E93 esterase G4278_16720 ENOG4107RNH Outer membrane receptor FepA G4278_16725 ENOG4108TSE Transferase G4278_16735 ENOG4106KXD ATP-dependent carboxylate-amine ligase (By similarity) G4278_16740 ENOG4105WQ6 Membrane G4278_16745 ENOG4105MSB protein, conserved in bacteria G4278_16750 ENOG4108RCM Nitroreductase G4278_16755 ENOG4105CUY Mechanosensitive ion channel G4278_16760 ENOG4105C85 amino acid G4278_16765 ENOG4108IJF Heavy metal efflux pump, CzcA G4278_16770 ENOG4105EP1 Efflux transporter rnd family, mfp subunit G4278_16775 ENOG410624V efflux system protein G4278_16780 ENOG4105ENJ RND efflux system, outer membrane lipoprotein G4278_16785 ENOG4105CK6 Two component transcriptional regulator (Winged helix family G4278_16790 ENOG4105GR3 Histidine kinase G4278_16800 ENOG41090FC Bacteriophage N4 receptor, outer membrane subunit G4278_16805 ENOG4105QUW G4278_16810 ENOG4108NC2 Outer membrane protease G4278_16815 ENOG4108WF3 methyltransferase G4278_16820 ENOG4105UZW Tail fiber assembly protein G4278_16825 ENOG4108KU3 Integrase G4278_16830 ENOG4108KU3 Integrase G4278_16850 ENOG4105WQ3 Rna-binding protein G4278_16865 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) G4278_16870 ENOG4105F10 Catalyzes the hydrolysis of the pyrophosphate bond of UDP-2,3-diacylglucosamine to yield 2,3-diacylglucosamine 1- phosphate (lipid X) and UMP (By similarity) G4278_16880 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) G4278_16885 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit G4278_16890 ENOG4105C5B carbamate kinase G4278_16895 ENOG4105G5A Protein of unknown function (DUF2877) G4278_16900 ENOG4107REC cytoplasmic protein G4278_16905 ENOG4107R1Q Membrane protein FdrA G4278_16910 ENOG4105DG4 malate L-lactate dehydrogenase G4278_16915 ENOG4105CE7 Amidase, hydantoinase carbamoylase family G4278_16920 ENOG4105S0E allantoin catabolism protein G4278_16925 ENOG4105BZW Glycerate kinase G4278_16930 ENOG4105DTE Xanthine uracil vitamin C permease G4278_16940 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease G4278_16945 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase G4278_16950 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) G4278_16955 ENOG41060W2 glyoxylate carboligase G4278_16960 ENOG4108N16 Negative regulator of allantoin and glyoxylate utilization operons. Binds to the gcl promoter and to the allS- allA intergenic region G4278_16965 ENOG4108Z2U ureidoglycolate hydrolase G4278_16970 ENOG4107653 Transcriptional regulator G4278_16980 ENOG4105CV6 ABC transporter, permease G4278_16985 ENOG4108I0Y (ABC) transporter G4278_16990 ENOG4108UJV acyl-CoA thioesterase i G4278_16995 ENOG4105E1F short-chain dehydrogenase reductase G4278_17000 ENOG4107QR8 Thioredoxin G4278_17005 ENOG4105C4B ABC transporter, permease G4278_17010 ENOG41083J0 (ABC) transporter G4278_17015 ENOG4107QX8 SPFH domain, Band 7 family protein G4278_17020 ENOG4105G5H Membrane G4278_17030 ENOG4108Z6Z Transcriptional regulator G4278_17035 ENOG4107RY6 amino acid G4278_17040 ENOG4105CSV Glutaminase G4278_17045 ENOG4105C59 p-type ATPase G4278_17050 ENOG41081XE plasmid maintenance system antidote protein, xre family G4278_17060 ENOG4105MBR gumn family G4278_17065 ENOG4108Z66 YbaK ebsC protein G4278_17070 ENOG4105CGH 5'-nucleotidase G4278_17075 ENOG4105EU0 Major facilitator Superfamily G4278_17080 ENOG4105CKD glutathione-regulated potassium-efflux system protein G4278_17085 ENOG4107RE1 Inosine-guanosine kinase G4278_17090 ENOG4105F2M alpha beta hydrolase fold-3 domain protein G4278_17120 ENOG4107QMP dna polymerase iii subunits gamma and tau G4278_17130 ENOG4105WD1 Membrane G4278_17135 ENOG4108URS primosomal replication protein n'' G4278_17140 ENOG4106428 Protein of unknown function (DUF2496) G4278_17145 ENOG4105EGS Mechanosensitive ion channel G4278_17150 ENOG4107XI7 Tetr family transcriptional regulator G4278_17155 ENOG4105C1P efflux transporter, rnd family, mfp subunit G4278_17160 ENOG4105BZS acriflavin resistance protein G4278_17165 ENOG4108UKR Biofilm formation regulator YbaJ G4278_17170 ENOG4105KF5 hemolysin expression-modulating protein G4278_17175 ENOG4108UW5 maltose o-acetyltransferase G4278_17180 ENOG4105GSJ Inner membrane protein ylaC G4278_17185 ENOG41066DG (EAL) domain protein G4278_17190 ENOG4105KCV RNA signal recognition particle 4.5S RNA G4278_17200 ENOG41080UX Methyltransferase G4278_17205 ENOG4108MNP Glycoprotein polysaccharide metabolism G4278_17210 ENOG4105C29 acyl-CoA thioesterase G4278_17215 ENOG4105BZU Histidine kinase G4278_17220 ENOG4108YZA Nitrogen regulatory protein pii G4278_17225 ENOG4105BZ1 (ABC) transporter G4278_17230 ENOG4105BZ1 (ABC) transporter G4278_17235 ENOG4108XM1 transcriptional regulator AsnC family G4278_17240 ENOG4108AZI Catalyzes the hydrolysis of 4-amino-2-methyl-5- hydroxymethylpyrimidine pyrophosphate (HMP-PP) to 4-amino-2- methyl-5-hydroxymethylpyrimidine phosphate (HMP-P) (By similarity) G4278_17245 ENOG4108NFA extracellular solute-binding protein G4278_17255 ENOG4108TGP Thioesterase superfamily protein G4278_17260 ENOG41083P1 competence protein ComEA helix-hairpin-helix repeat protein G4278_17265 ENOG4105EIN peptidylprolyl cis-trans isomerase G4278_17270 ENOG4105K70 DNA-binding protein G4278_17275 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) G4278_17290 ENOG4105DEA Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation G4278_17295 ENOG4105M85 Bola protein G4278_17300 ENOG4105IEY (LipO)protein G4278_17305 ENOG4105EYM Major Facilitator superfamily G4278_17310 ENOG4105E2S oxidase) subunit II G4278_17315 ENOG4105BZ9 Cytochrome C oxidase, subunit I G4278_17320 ENOG4105CCU oxidase (Subunit III) G4278_17325 ENOG41090KH cytochrome o ubiquinol oxidase (subunit iv) G4278_17335 ENOG4107RDB Major Facilitator G4278_17345 ENOG4108JZF Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) G4278_17350 ENOG4107S0N DJ-1 family G4278_17365 ENOG4105CTB Polyprenyl synthetase G4278_17375 ENOG4105CPC Aldo Keto reductase G4278_17380 ENOG4108ZAI phosphatidylglycerophosphatase a G4278_17385 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) G4278_17395 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) G4278_17400 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) G4278_17410 ENOG4108KIC (LipO)protein G4278_17415 ENOG4105DRB nucleoside-specific channel-forming protein G4278_17420 ENOG4105N1F Hnh endonuclease G4278_17425 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) G4278_17430 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) G4278_17435 ENOG4105VIE preprotein translocase, subunit YajC G4278_17445 ENOG4105E2N Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity) G4278_17450 ENOG4108ZYK Acyl carrier protein phosphodiesterase G4278_17455 ENOG4107R28 alpha amylase, catalytic region G4278_17460 ENOG4105C85 amino acid G4278_17465 ENOG4105CWM branched-chain amino acid transport system II carrier protein G4278_17470 ENOG4105BZU Histidine kinase G4278_17475 ENOG4105CK6 Two component transcriptional regulator (Winged helix family G4278_17480 ENOG4107RH8 nuclease SbcCD subunit D G4278_17485 ENOG4105EYH Exonuclease G4278_17490 ENOG4105F27 Major Facilitator G4278_17495 ENOG4105DKQ ROK family G4278_17520 ENOG4105HBA AroM protein G4278_17525 ENOG4105SS3 G4278_17540 ENOG4105II7 pyrroline-5-carboxylate reductase G4278_17545 ENOG4105BZU Histidine kinase G4278_17550 ENOG4105VIF phosphate starvation-inducible protein G4278_17555 ENOG4105G6Z alkaline phosphatase G4278_17570 ENOG4105CPF Cell wall formation (By similarity) G4278_17575 ENOG4105UNH Membrane G4278_17580 ENOG4105FR5 inner membrane protein YaiY G4278_17585 ENOG4107QS8 (LipO)protein G4278_17590 ENOG4108DQG in Escherichia coli SbmA is involved in uptake of microcin J25 G4278_17595 ENOG4107R6D beta-lactam binding protein AmpH G4278_17600 ENOG4108PNB DNA-binding transcriptional regulator G4278_17610 ENOG4105D52 delta-aminolevulinic acid dehydratase G4278_17615 ENOG4105E2B Taurine dioxygenase G4278_17620 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component G4278_17625 ENOG4108IY8 ABC, transporter G4278_17630 ENOG4106FTQ Taurine ABC transporter, periplasmic G4278_17635 ENOG4107W19 lmbE family G4278_17640 ENOG4108PBI Polysaccharide metabolism G4278_17650 ENOG4105SRB Uncharacterized protein yaiO G4278_17665 ENOG4105C4W S-formylglutathione hydrolase G4278_17670 ENOG4105IUQ nucleoprotein polynucleotide-associated enzyme G4278_17680 ENOG4105ETE Transcriptional regulator (LacI family G4278_17685 ENOG4105CNT hydrolase family 2 G4278_17690 ENOG4105U0F oligosaccharide H symporter, major facilitator superfamily (MFS) G4278_17695 ENOG4108UW5 maltose o-acetyltransferase G4278_17700 ENOG4105DZC cytosine deaminase G4278_17705 ENOG4105DQW permease for cytosine purines, uracil, thiamine, allantoin G4278_17710 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) G4278_17715 ENOG4105DXD 2-methylcitrate dehydratase G4278_17720 ENOG4105BZN citrate synthase G4278_17725 ENOG4105CR4 methylisocitrate lyase G4278_17730 ENOG4108JU7 Transcriptional regulator G4278_17735 ENOG4105TDT uncharacterized protein yahO G4278_17740 ENOG4105E82 cytochrome subunit of dehydrogenase G4278_17750 ENOG4105DQ4 alcohol dehydrogenase G4278_17755 ENOG4105DZC cytosine deaminase G4278_17760 ENOG4105C5B carbamate kinase G4278_17770 ENOG4107REC cytoplasmic protein G4278_17775 ENOG4107R1Q Membrane protein FdrA G4278_17780 ENOG4105N16 Protein of unknown function (DUF2877) G4278_17785 ENOG4107SNB ankyrin repeat protein YahD G4278_17790 ENOG4105SZ2 membrAne G4278_17795 ENOG4108NUU Transcriptional regulator G4278_17800 ENOG4105BZU Histidine kinase G4278_17805 ENOG4105C94 Transporter G4278_17815 ENOG4105C26 Dehydrogenase G4278_17820 ENOG4105CZ6 Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine (By similarity) G4278_17825 ENOG4108W9T type 1 fimbriae regulatory protein G4278_17830 ENOG4105BZU Histidine kinase G4278_17855 ENOG4108ZZK Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source (By similarity) G4278_17860 ENOG4107QR9 Iron-sulfur cluster binding protein G4278_17865 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) G4278_17870 ENOG4108K01 transcriptional regulator G4278_17875 ENOG4107QN2 dihydrolipoyl dehydrogenase G4278_17880 ENOG41066GK UPF0379 protein ykgI G4278_17885 ENOG4108KBJ Inner membrane protein YkgB G4278_17890 ENOG4105CV8 reductase G4278_17910 ENOG4107SET aldo keto reductase G4278_17915 ENOG4105EQ2 LysR family Transcriptional regulator G4278_17920 ENOG410642W LysR family Transcriptional regulator G4278_17925 ENOG4105ENX hydrolase G4278_17930 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase G4278_17970 ENOG4108N3D putative enzyme G4278_17975 ENOG4106PYX Receptor G4278_17985 ENOG4105PI0 Ferredoxin G4278_17995 ENOG4105R3P Inner membrane protein yagU G4278_18030 ENOG4105C2S Catalyzes the NADPH dependent reduction of L-gamma- glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate (By similarity) G4278_18040 ENOG4105FCK Membrane G4278_18045 ENOG4108UVK Binds to the sigma-S subunit of RNA polymerase, activating expression of sigma-S-regulated genes. Stimulates RNA polymerase holoenzyme formation and may bind to several other sigma factors, such as sigma-70 and sigma-32 (By similarity) G4278_18050 ENOG4105V1F Fermentation respiration switch protein G4278_18060 ENOG4105CIN aminoacyl-histidine dipeptidase G4278_18065 ENOG4108S2Y peptide Chain Release factor G4278_18075 ENOG4108HYG acetyltransferase G4278_18080 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) G4278_18095 ENOG4108YS0 lipoprotein YafL G4278_18100 ENOG4105F7V ErfK ybiS ycfS ynhG family protein G4278_18105 ENOG4105E7A Glutamine amidotransferase G4278_18115 ENOG4107QPN acyl-Coa dehydrogenase G4278_18120 ENOG4108WN0 inhibitor of vertebrate lysozyme G4278_18125 ENOG4105CZ7 nitrilase cyanide hydratase and apolipoprotein n-acyltransferase G4278_18145 ENOG4108KX4 response regulator G4278_18190 ENOG4108BMY protease G4278_18210 ENOG4105CKT filamentous hemagglutinin G4278_18215 ENOG4105CKT filamentous hemagglutinin G4278_18230 ENOG4105D5K Hemolysin activator protein G4278_18245 ENOG4108X7Y Mannitol-specific cryptic phosphotransferase enzyme iia G4278_18255 ENOG4105CZC PTS system ascorbate-specific transporter subunit IIC G4278_18270 ENOG4105EDR glucose galactose transporter G4278_18280 ENOG4107FB0 transcriptional regulator DeoR family G4278_18285 ENOG4105M71 acetolactate synthase 1 regulatory subunit G4278_18315 ENOG4105M5J Cupin 2, conserved barrel domain protein G4278_18325 ENOG4105CAZ oligogalacturonide lyase G4278_18390 ENOG4108F1U ABC transporter G4278_18395 ENOG4105EHG Permease protein G4278_18420 ENOG4108EU4 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) G4278_18435 ENOG4108F5E vimentin G4278_18440 ENOG4108YIV G4278_18470 ENOG4106H6R UPF0380 protein G4278_18480 ENOG4105MFG Antirestriction protein G4278_18485 ENOG4108YGG dna repair protein G4278_18500 ENOG4105MAW Antitoxin component of a toxin-antitoxin (TA) module. Labile antitoxin that counteracts the effect of the CbtA (YeeV) toxin. It does not bind to the cognate toxin but instead binds to MreB and FtsZ (the toxin targets), enhancing their polymerization by forming higher-order bundles G4278_18535 ENOG4105FKG DNA packaging protein G4278_18550 ENOG4105IM0 capsid protein G4278_18625 ENOG4108YXQ IS66 Orf2 family protein G4278_18650 ENOG4107RZZ dna polymerase iii epsilon subunit G4278_18660 ENOG4105D1A Methyltransferase G4278_18665 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) G4278_18670 ENOG4105E9H Lytic Murein transglycosylase G4278_18675 ENOG4105F2W methyltransferase G4278_18685 ENOG4105HEI LysR family (Transcriptional regulator G4278_18690 ENOG4105CV8 reductase G4278_18725 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase G4278_18730 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) G4278_18735 ENOG4108UMI ABC transporter, permease G4278_18740 ENOG4105D01 (LipO)protein G4278_18745 ENOG4108R8X outer membrane lipoprotein G4278_18750 ENOG4108R96 Methyltransferase, YaeB family G4278_18760 ENOG4108UY0 (LipO)protein G4278_18770 ENOG4107EII Lipoprotein involved with copper homeostasis and adhesion G4278_18775 ENOG4108YZN class I peptide chain release factor G4278_18780 ENOG4108VWS Yaeq family G4278_18785 ENOG4105W1I UPF0253 protein G4278_18790 ENOG4105M1T rho-binding antiterminator G4278_18795 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) G4278_18800 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase G4278_18805 ENOG4105CXN decarboxylase G4278_18810 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) G4278_18815 ENOG4105C0B DNA polymerase III (alpha subunit) G4278_18820 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) G4278_18840 ENOG4105D7M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) G4278_18845 ENOG4108RFI Molecular chaperone that interacts specifically with outer membrane proteins, thus maintaining the solubility of early folding intermediates during passage through the periplasm (By similarity) G4278_18855 ENOG4105DZP Membrane-associated zinc metalloprotease G4278_18860 ENOG4105KNE Phosphatidate cytidylyltransferase G4278_18865 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) G4278_18870 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) G4278_18895 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) G4278_18900 ENOG4105E1P Modifies, by uridylylation or deuridylylation the PII (GlnB) regulatory protein (By similarity) G4278_18905 ENOG4105DMJ Catalyzes the transfer of an acetyl group from acetyl- CoA to tetrahydrodipicolinate (By similarity) G4278_18915 ENOG4108IXP Carbohydrate diacid transcriptional activator CdaR G4278_18920 ENOG4105C0H protease G4278_18935 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) G4278_18940 ENOG4105EN6 Membrane G4278_18965 ENOG4105S6R Iron-hydroxamate transporter permease subunit G4278_18970 ENOG4105J76 Periplasmic binding protein G4278_18975 ENOG4105E0A ABC, transporter G4278_18980 ENOG4105E0K tonB-dependent siderophore receptor G4278_18985 ENOG4105BZ4 penicillin-binding protein G4278_18990 ENOG4105CQ7 ATP-dependent helicase G4278_18995 ENOG4107XID 2'-5' rna ligase G4278_19010 ENOG4106F3G Catalyzes the tRNA-independent activation of glutamate in presence of ATP and the subsequent transfer of glutamate onto a tRNA(Asp). Glutamate is transferred on the 2-amino-5-(4,5- dihydroxy-2-cyclopenten-1-yl) moiety of the queuosine in the wobble position of the QUC anticodon (By similarity) G4278_19015 ENOG4105DJ0 Poly(A) Polymerase G4278_19020 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase G4278_19030 ENOG4108VEV chaperone G4278_19035 ENOG4105CW0 outer membrane usher protein G4278_19040 ENOG4108XEY fimbrial-like adhesin protein G4278_19045 ENOG4105SYG Fimbrial protein G4278_19050 ENOG4105SN2 fimbrial-like adhesin protein G4278_19055 ENOG4105P0Q fimbrial-like protein YadC G4278_19065 ENOG4108IAA Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate (By similarity) G4278_19070 ENOG4108A32 Transposase G4278_19080 ENOG4107BJW polysaccharide deacetylase G4278_19085 ENOG4108YTN IIa component G4278_19090 ENOG4105E3A (ABC) transporter G4278_19095 ENOG4105DA5 (ABC) transporter G4278_19100 ENOG41077A9 carbonic anhydrase G4278_19105 ENOG4108UGV hypoxanthine phosphoribosyltransferase G4278_19110 ENOG4105DZG Dehydrogenase G4278_19115 ENOG4105E3B Multicopper oxidase G4278_19120 ENOG4108ZRK uncharacterized protein yacC G4278_19140 ENOG4107QIJ Aconitate hydratase 2 G4278_19145 ENOG4108NST exported protein G4278_19150 ENOG4107QN2 dihydrolipoyl dehydrogenase G4278_19155 ENOG4107QSN dihydrolipoamide acetyltransferase G4278_19160 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) G4278_19165 ENOG41073TP transcriptional regulator G4278_19170 ENOG41060S4 immunity protein G4278_19180 ENOG41060S4 immunity protein G4278_19195 ENOG4105GMB type VI secretion system effector, hcp1 family G4278_19200 ENOG4105C85 amino acid G4278_19205 ENOG4106A72 regulatory protein AmpE G4278_19210 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase G4278_19215 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase G4278_19220 ENOG4108ZUW Major pilin subunit G4278_19225 ENOG4107QHF type ii secretion system protein e G4278_19230 ENOG4105D7Q type ii secretion system G4278_19240 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) G4278_19250 ENOG41067SF Inhibits all the catalytic activities of DNA gyrase by preventing its interaction with DNA. Acts by binding directly to the C-terminal domain of GyrB, which probably disrupts DNA binding by the gyrase (By similarity) G4278_19260 ENOG4105M6F mutator MutT protein G4278_19280 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) G4278_19285 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) G4278_19290 ENOG4105K7E Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity) G4278_19295 ENOG4105CPF Cell wall formation (By similarity) G4278_19310 ENOG4105CNI cell division protein FtsW G4278_19315 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) G4278_19325 ENOG4108EQQ Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity) G4278_19330 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) G4278_19335 ENOG4105CJN penicillin-binding protein G4278_19340 ENOG41063Y6 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) G4278_19345 ENOG4105CGJ Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA (By similarity) G4278_19355 ENOG4107B7Y DNA-binding transcriptional regulator FruR G4278_19365 ENOG4108ZP8 Acetolactate synthase small subunit G4278_19370 ENOG4105C7K acetolactate synthase G4278_19375 ENOG41064T2 transcriptional regulator, lysR family G4278_19390 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) G4278_19415 ENOG4105DP9 ABC transporter G4278_19420 ENOG4106SMU thiamine transporter membrane protein G4278_19425 ENOG4107T0D ABC, transporter G4278_19430 ENOG4108KF1 Membrane G4278_19445 ENOG41063TF transcriptional regulator (AraC G4278_19450 ENOG4105EF1 ribulokinase G4278_19455 ENOG4105CAC Catalyzes the conversion of L-arabinose to L-ribulose (By similarity) G4278_19460 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase G4278_19465 ENOG4105CQ2 DNA polymerase G4278_19475 ENOG4105D3G Pseudouridine synthase G4278_19480 ENOG41066UG Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host (By similarity) G4278_19490 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) G4278_19495 ENOG4105CEZ Catalyzes the NAD(P)-dependent oxidation of 4- (phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4- (phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP) (By similarity) G4278_19525 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) G4278_19530 ENOG4105CKD glutathione-regulated potassium-efflux system protein G4278_19540 ENOG4105C54 Major Facilitator superfamily G4278_19545 ENOG4105IBM Could be part of an electron transfer system required for anaerobic carnitine reduction. Could be a 3Fe-4S cluster- containing protein G4278_19550 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase G4278_19580 ENOG4105CEY Amp-dependent synthetase and ligase G4278_19585 ENOG4106YT9 Enoyl-CoA hydratase G4278_19595 ENOG4108XNW Transcriptional activatory protein CaiF G4278_19600 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain G4278_19605 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain G4278_19630 ENOG41090X3 Peptidyl-prolyl cis-trans isomerase G4278_19645 ENOG4105DTN riboflavin biosynthesis protein ribF G4278_19650 ENOG410647N response to DNA damage stimulus G4278_19660 ENOG41063Z6 transcriptional regulator, lysR family G4278_19675 ENOG41061MV Arylsulfatase G4278_19685 ENOG4105WI6 cell killing protein encoded within cryptic prophage G4278_19705 ENOG4108QUJ UPF0174 protein YaaW G4278_19710 ENOG4106HK8 GPR1 FUN34 yaaH family protein G4278_19715 ENOG4108RIR Molybdenum cofactor biosynthesis protein G4278_19725 ENOG4105BZG amino acid carrier protein G4278_19735 ENOG41062C6 Protein of unknown function (DUF2502) G4278_19740 ENOG4105D98 threonine synthase G4278_19745 ENOG4105D5I Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity) G4278_19750 ENOG4105CFH Aspartokinase G4278_19760 ENOG4106FVC RNA methyltransferase G4278_19765 ENOG410759A G4278_19770 ENOG41065U4 response regulator G4278_19775 ENOG4105CT7 inner membrane cred family protein G4278_19780 ENOG4105EB3 Histidine kinase G4278_19785 ENOG4105E3W Two component transcriptional regulator (Winged helix family G4278_19790 ENOG4108RH0 Crea protein G4278_19795 ENOG4105UEI Transcriptional Regulator AraC Family G4278_19815 ENOG4107SC1 transglycosylase G4278_19820 ENOG4105C5H ABC transporter G4278_19830 ENOG4105W2W Cytotoxic translational repressor of toxin-antitoxin stability system G4278_19835 ENOG4107VZS Nicotinamide-nucleotide adenylyltransferase G4278_19840 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) G4278_19845 ENOG4105EAC phosphoserine phosphatase G4278_19850 ENOG41062Z9 Membrane G4278_19855 ENOG4107RMF Catalyzes both the ATP-dependent activation of exogenously supplied lipoate to lipoyl-AMP and the transfer of the activated lipoyl onto the lipoyl domains of lipoate-dependent enzymes (By similarity) G4278_19860 ENOG4105EUP HipA domain protein G4278_19865 ENOG4105D3A purine nucleoside phosphorylase DeoD-type G4278_19880 ENOG4105FCI Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity) G4278_19885 ENOG4105G0K glycine radical enzyme YjjI family G4278_19890 ENOG41076CZ activating enzyme G4278_19895 ENOG4105EYA deoxyribonuclease G4278_19900 ENOG4108NRW Phospholipase, patatin family G4278_19910 ENOG4105K3G Periplasmic Protein G4278_19920 ENOG4105PAD Hydrolase G4278_19925 ENOG4105KEG ribosomal-protein-alanine acetyltransferase G4278_19930 ENOG4108WPU DNA polymerase III subunit psi G4278_19935 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) G4278_19955 ENOG4105YBH Protein of unknown function (DUF1435) G4278_19960 ENOG4108819 ferric iron reductase G4278_19965 ENOG4108T94 DNA-binding transcriptional activator BglJ G4278_19970 ENOG4108N8T regulatoR G4278_19975 ENOG4105DWK Membrane G4278_19990 ENOG4106CVF DNA replication protein G4278_19995 ENOG4105RI1 glycoprotein receptor G4278_20000 ENOG4107RES phosphoglycerol transferase I G4278_20005 ENOG4105CPQ Dehydrogenase G4278_20010 ENOG410617M Transcriptional regulator G4278_20015 ENOG4105EEQ Na H antiporter G4278_20020 ENOG4108ERU trap dicarboxylate transporter subunit DctP G4278_20030 ENOG4105CG6 trap dicarboxylate transporter dctm subunit G4278_20035 ENOG4105C8Q Methyl-accepting chemotaxis G4278_20040 ENOG4105D22 carbon starvation protein G4278_20045 ENOG4105VCD cytoplasmic protein G4278_20050 ENOG4105CKI cobalamin synthesis protein G4278_20060 ENOG4108F3G Type I restriction-modification system, R subunit G4278_20070 ENOG4107QTH restriction modification system DNA specificity domain G4278_20085 ENOG4106DIZ Domain of unknown function (DUF1127) G4278_20095 ENOG4106BRA Membrane G4278_20100 ENOG4105DCU 2-hydroxyglutaryl-CoA dehydratase G4278_20105 ENOG4105CIZ coA-substrate-specific enzyme activase G4278_20120 ENOG4105CBP Major Facilitator G4278_20130 ENOG41074DU domain protein G4278_20135 ENOG4108P2H Inner membrane protein YjiG G4278_20140 ENOG4105DYB Isoaspartyl dipeptidase G4278_20145 ENOG4107YNJ LysR family Transcriptional regulator G4278_20155 ENOG4106PZD Inhibits RpoS proteolysis by regulating RssB activity, thereby increasing the stability of the sigma stress factor RpoS during oxidative stress. Its effect on RpoS stability is due to its interaction with RssB, which probably blocks the interaction of RssB with RpoS, and the consequent delivery of the RssB-RpoS complex to the ClpXP protein degradation pathway G4278_20160 ENOG4105C6F GntR Family Transcriptional Regulator G4278_20165 ENOG4105DEI Mannitol dehydrogenase G4278_20175 ENOG4107EFN gluconate transport system permease 3 G4278_20180 ENOG410643X FIMH SUBUNIT MANNOSE-sensitive type 1 fimbrial adhesin G4278_20185 ENOG4108T65 Fimbrial G4278_20190 ENOG4108SQA Fimbrial G4278_20195 ENOG4105CW0 outer membrane usher protein G4278_20200 ENOG4108NAE Fimbrial chaperone protein G4278_20205 ENOG4108S54 Fimbrial protein G4278_20210 ENOG4108RQP Major type 1 subunit fimbrin G4278_20215 ENOG4105E71 FimE is one of the 2 regulatory proteins which control the phase variation of type 1 fimbriae in E.coli. These proteins mediate the periodic inversion of a 300bp DNA segment that harbors the promoter for the fimbrial structural gene, fimA. FimE switches fimA off G4278_20220 ENOG4108W9T type 1 fimbriae regulatory protein G4278_20225 ENOG41069FU Outer membrane channel protein allowing the entry of N- acetylneuraminic acid (Neu5Ac, the most abundant sialic acid on host cell surfaces) into the bacteria G4278_20230 ENOG4108MX5 Converts alpha-N-acetylneuranimic acid (Neu5Ac) to the beta-anomer, accelerating the equilibrium between the alpha- and beta-anomers. Probably facilitates sialidase-negative bacteria to compete sucessfully for limited amounts of extracellular Neu5Ac, which is likely taken up in the beta-anomer. In addition, the rapid removal of sialic acid from solution might be advantageous to the bacterium to damp down host responses (By similarity) G4278_20295 ENOG4105D8D Type III G4278_20320 ENOG4105MAW Antitoxin component of a toxin-antitoxin (TA) module. Labile antitoxin that counteracts the effect of the CbtA (YeeV) toxin. It does not bind to the cognate toxin but instead binds to MreB and FtsZ (the toxin targets), enhancing their polymerization by forming higher-order bundles G4278_20330 ENOG4108YGG dna repair protein G4278_20335 ENOG4106549 Antirestriction protein G4278_20340 ENOG4106H6R UPF0380 protein G4278_20350 ENOG4108YIV G4278_20355 ENOG4108F5E vimentin G4278_20360 ENOG4105F4K antigen 43 G4278_20380 ENOG4105EKQ RNA-directed DNA polymerase G4278_20470 ENOG4105DQ4 alcohol dehydrogenase G4278_20475 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family G4278_20480 ENOG4105CPQ Dehydrogenase G4278_20485 ENOG4105CHR reductase G4278_20490 ENOG4105C6Z Gluconate G4278_20495 ENOG4105K2J Transcriptional regulator G4278_20500 ENOG4105D7A ATP-binding protein G4278_20505 ENOG4108K5H permease YjgP YjgQ family protein G4278_20510 ENOG4108M8S permease YjgP YjgQ family protein G4278_20520 ENOG4105MYG DNA polymerase iii, chi subunit G4278_20525 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) G4278_20530 ENOG4108M3P Membrane G4278_20535 ENOG4108MJ3 acetyltransferase G4278_20540 ENOG4105KQT Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome (By similarity) G4278_20545 ENOG4105DBV ornithine carbamoyltransferase G4278_20550 ENOG4105XEP YhcH YjgK YiaL family protein G4278_20565 ENOG4105DBV ornithine carbamoyltransferase G4278_20570 ENOG4105CSX c4-dicarboxylate anaerobic carrier G4278_20580 ENOG4107C93 pyrBI operon leader peptide G4278_20595 ENOG4105KME endoribonuclease L-psp G4278_20600 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic G4278_20610 ENOG4105D4X repressor G4278_20615 ENOG4105C5Y PTS System G4278_20620 ENOG4105CG3 alpha amylase, catalytic region G4278_20625 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase G4278_20630 ENOG4108RDD Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine (By similarity) G4278_20635 ENOG4108XVM Cytochrome b(562) G4278_20640 ENOG4105CMS peptidase U62, modulator of DNA gyrase G4278_20645 ENOG4105N42 UPF0307 protein G4278_20650 ENOG4105DFU Cell wall formation (By similarity) G4278_20660 ENOG41062B0 ABC transporter, permease G4278_20665 ENOG4107R9N ABC transporter G4278_20670 ENOG4105C2J ABC transporter G4278_20675 ENOG4107R5U Periplasmic binding protein LacI transcriptional regulator G4278_20680 ENOG4105F0N pyrophosphate phospho-hydrolase G4278_20690 ENOG4108ZHD aig2 family G4278_20695 ENOG4105MA0 exported protein G4278_20700 ENOG4105CFU surface antigen G4278_20705 ENOG4108HW8 Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine (By similarity) G4278_20710 ENOG4105C37 (CBS) domain G4278_20715 ENOG41061GZ Protein of unknown function (DUF1107) G4278_20720 ENOG4108UUE Transcriptional regulator G4278_20725 ENOG4108RNI 3'(2')5'-bisphosphate nucleotidase G4278_20730 ENOG4107RNS bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase 3'-nucleotidase periplasmic G4278_20735 ENOG4105KVH Transcriptional regulator G4278_20740 ENOG4105ECR NmrA family G4278_20745 ENOG4105DXC membrane G4278_20760 ENOG4108V1T peptidylprolyl cis-trans isomerase G4278_20765 ENOG4105FHY Opacity-associated protein A G4278_20775 ENOG4105CHR reductase G4278_20785 ENOG4105E39 Enoyl-CoA hydratase G4278_20790 ENOG4107R0K CoA transferase having broad substrate specificity for short-chain acyl-CoA thioesters with the activity decreasing when the length of the carboxylic acid chain exceeds four carbons (By similarity) G4278_20795 ENOG4107S3R L-aspartate oxidase G4278_20800 ENOG4105DPW Major facilitator superfamily MFS_1 G4278_20820 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) G4278_20835 ENOG4105KIT UPF0379 protein yjfY G4278_20840 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase G4278_20855 ENOG4106ETB IIa component G4278_20865 ENOG4105CZC PTS system ascorbate-specific transporter subunit IIC G4278_20880 ENOG4108MXZ Esterase G4278_20885 ENOG4105WSB biofilm stress and motility protein A G4278_20890 ENOG4105S17 UPF0379 protein yjfN G4278_20895 ENOG4105CSU acyl-Coa dehydrogenase G4278_20900 ENOG4106032 Glutathionylspermidine synthase G4278_20905 ENOG4108KXT Conserved Protein G4278_20910 ENOG4105Z6B inner membrane protein yjfl G4278_20915 ENOG4107VNS Protein of unknown function (DUF2491) G4278_20920 ENOG4108P9J Phage shock protein A G4278_20925 ENOG4105FUX Conserved Protein G4278_20930 ENOG4105C2N RNA methyltransferase TrmH family group 3 G4278_20935 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) G4278_20955 ENOG4105EPW hflc protein G4278_20960 ENOG4107QJR hflk protein G4278_20965 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) G4278_20980 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) G4278_20985 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase G4278_20990 ENOG4105K8N protein family UPF0079, ATPase G4278_20995 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) G4278_21000 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) G4278_21040 ENOG4105EGS Mechanosensitive ion channel G4278_21045 ENOG4107SC7 Inner membrane transporter yjeM G4278_21055 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) G4278_21060 ENOG4105E33 succinate dehydrogenase G4278_21075 ENOG41066YJ Beta-lactamase G4278_21080 ENOG4105QNF Outer membrane lipoprotein G4278_21085 ENOG4105KPY Small multidrug resistance protein G4278_21090 ENOG4106BSU Entericidin B G4278_21095 ENOG4107PEH Entericidin EcnA/B family G4278_21105 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein G4278_21110 ENOG4105MTB Uncharacterized protein YjeJ G4278_21115 ENOG4108ZVF (LipO)protein G4278_21130 ENOG4105DVH amino acid G4278_21135 ENOG4108YH1 overproduction of this protein in Escherichia coli inhibits the F plasmid-mediated exclusion of bacteriophage T7 G4278_21140 ENOG4108IJ0 Aspartate ammonia-lyase G4278_21145 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter G4278_21155 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) G4278_21160 ENOG4108SIC Transcriptional regulator G4278_21180 ENOG4108I6E Sulfatase G4278_21185 ENOG4105T40 surface antigen msp4 family protein G4278_21200 ENOG41067TZ transcriptional regulator, MarR family G4278_21220 ENOG4106CXJ Residues 2 to 179 of 179 are 100.00 pct identical to residues 1 to 178 of 178 from SwissProt.40 sp P42190 PAPK_ECOLI PROTEIN PAPK PRECURSOR G4278_21230 ENOG4106P2F Pfam:Pili_assembly_C G4278_21235 ENOG4106PG1 outer membrane usher protein G4278_21240 ENOG4108ZJG MrfB protein G4278_21305 ENOG4108SB3 DoxX Family G4278_21320 ENOG4108R86 Transcriptional regulator G4278_21325 ENOG4105E5H Transposase G4278_21330 ENOG4108YXQ IS66 Orf2 family protein G4278_21365 ENOG4105C42 Type I secretion membrane fusion protein (HlyD G4278_21370 ENOG4108JJA ABC, transporter G4278_21375 ENOG4107V48 Hemolysin-type calcium-binding G4278_21380 ENOG4108RC6 RTX toxin G4278_21390 ENOG4105EQW The exact function is not known. Can catalyze the reduction of a variety of substrates like dimethyl sulfoxide, trimethylamine N-oxide, phenylmethyl sulfoxide and L-methionine sulfoxide. Cannot reduce cyclic N-oxides. Shows no activity as sulfite oxidase (By similarity) G4278_21400 ENOG4105DPZ Two component transcriptional regulator (Winged helix family G4278_21405 ENOG4105ES5 Histidine kinase G4278_21425 ENOG4105DC6 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity) G4278_21430 ENOG4105NI8 Cytosine-specific methyltransferase G4278_21450 ENOG4106QAN G4278_21455 ENOG4105CKT filamentous hemagglutinin G4278_21460 ENOG4105D5K Hemolysin activator protein G4278_21525 ENOG4105TS0 gtp-binding protein G4278_21530 ENOG4108KZE transcriptional regulator G4278_21545 ENOG4106H6R UPF0380 protein G4278_21550 ENOG4106549 Antirestriction protein G4278_21555 ENOG4108YGG dna repair protein G4278_21565 ENOG4105MAW Antitoxin component of a toxin-antitoxin (TA) module. Labile antitoxin that counteracts the effect of the CbtA (YeeV) toxin. It does not bind to the cognate toxin but instead binds to MreB and FtsZ (the toxin targets), enhancing their polymerization by forming higher-order bundles G4278_21590 ENOG4108M3R transcriptional activator CadC G4278_21595 ENOG4105D5Q Arginine ornithine antiporter G4278_21600 ENOG4105CXN decarboxylase G4278_21605 ENOG4105DUX Transporter G4278_21610 ENOG4105CRK lysyL-tRNA synthetase G4278_21625 ENOG410830R acetyltransferase G4278_21630 ENOG4105VR1 Pfam:DUF1271 G4278_21635 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism G4278_21640 ENOG4108MRH transcriptional regulatory protein G4278_21645 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter G4278_21650 ENOG4107GFK fumarate G4278_21660 ENOG4105F8D glycoside hydrolase family 4 G4278_21665 ENOG4108K2B transcriptional regulator G4278_21670 ENOG4105CXN decarboxylase G4278_21675 ENOG4106ZGR Transcriptional regulator G4278_21680 ENOG4105D5Q Arginine ornithine antiporter G4278_21685 ENOG4105DIJ Phosphoethanolamine transferase G4278_21690 ENOG4105XJC Two component transcriptional regulator (Winged helix family G4278_21695 ENOG4105ECM Sensor protein basS pmrB G4278_21705 ENOG4105CSH Transporter G4278_21710 ENOG4108YIV G4278_21715 ENOG4108F5E vimentin G4278_21720 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA G4278_21725 ENOG4108SQ4 Glyoxalase Bleomycin resistance protein (Dioxygenase G4278_21730 ENOG4105D5T phosphonate abc transporter G4278_21735 ENOG4105EHI Phosphonate ABC transporter, periplasmic G4278_21745 ENOG4107RJJ Transcriptional regulator G4278_21750 ENOG4105KQZ Phosphonate C-P lyase system protein PhnG G4278_21755 ENOG4105KZ6 phosphonate C-P lyase system protein PhnH G4278_21760 ENOG4105EKV Phosphonate metabolism protein G4278_21765 ENOG4105FT8 Phosphonate metabolism G4278_21770 ENOG4105ENV phosphonate C-P lyase system protein PhnK G4278_21775 ENOG4105HRV phosphonate c-p lyase system protein phnl G4278_21780 ENOG4105FD8 phosphonate metabolism protein PhnM G4278_21790 ENOG410849A acetyltransferase, (GNAT) family G4278_21795 ENOG4107SA6 carbon-phosphorus lyase complex accessory protein G4278_21805 ENOG4108YZG isomerase G4278_21810 ENOG4105NYY transcriptional regulator, RpiR G4278_21815 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator G4278_21820 ENOG4105C2J ABC transporter G4278_21825 ENOG4105CNN ABC, transporter G4278_21830 ENOG4105UP7 3-epimerase G4278_21835 ENOG4107TFG D-allose kinase G4278_21840 ENOG4105EUZ Beta-lactamase domain protein G4278_21850 ENOG4105J12 Multidrug resistance protein mdtN G4278_21855 ENOG4108MI0 Resistance protein G4278_21860 ENOG4105ETP RND efflux system, outer membrane lipoprotein G4278_21875 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component G4278_21880 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component G4278_21885 ENOG4105C3U ABC transporter G4278_21890 ENOG4108JQ7 (ABC) transporter G4278_21895 ENOG41082ND Uncharacterized protein yjcO G4278_21900 ENOG4105CK2 sodium dicarboxylate symporter G4278_21905 ENOG4108W0S formate-dependent nitrite reductase complex G4278_21915 ENOG4108QKW cytochrome c-type biogenesis protein G4278_21920 ENOG4105DVI reductase, NrfD G4278_21925 ENOG4105D3S 4Fe-4S Ferredoxin, iron-sulfur binding domain protein G4278_21930 ENOG4105JJ8 Cytochrome c nitrite reductase, pentaheme subunit G4278_21940 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) G4278_21945 ENOG41062QD Membrane G4278_21955 ENOG41067MG lrgb family G4278_21965 ENOG4105CMU LysR family (Transcriptional regulator G4278_21970 ENOG4105EEQ Na H antiporter G4278_21975 ENOG4105C7N Xanthine uracil vitamin C permease G4278_21980 ENOG4108Z4X TRANSCRIPTIONal G4278_21985 ENOG4108W3Q Transcriptional regulator G4278_21990 ENOG4108M8H domain protein G4278_21995 ENOG4105PMV Membrane G4278_22000 ENOG4108UUM single-stranded DNA-binding protein G4278_22005 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) G4278_22010 ENOG4105MSB protein, conserved in bacteria G4278_22015 ENOG4108YXI Secondary thiamine-phosphate synthase enzyme G4278_22020 ENOG4105F0S class B acid phosphatase G4278_22025 ENOG4105CQZ Histidine kinase G4278_22030 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family G4278_22035 ENOG4105DG4 malate L-lactate dehydrogenase G4278_22040 ENOG4107QPK )-transporter G4278_22045 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha G4278_22050 ENOG4105CMV Succinyl-CoA synthetase subunit beta G4278_22055 ENOG4107QN2 dihydrolipoyl dehydrogenase G4278_22060 ENOG4105C7S Dehydrogenase G4278_22065 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 G4278_22070 ENOG4105CGF Aromatic amino acid aminotransferase G4278_22075 ENOG4107VZS Nicotinamide-nucleotide adenylyltransferase G4278_22080 ENOG4106Z1T Nicotinamide Mononucleotide Transporter G4278_22085 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) G4278_22095 ENOG4105CDU Replicative dna helicase G4278_22100 ENOG4105ETE Transcriptional regulator (LacI family G4278_22105 ENOG4108IIG CoA transferase having broad substrate specificity for short-chain acyl-CoA thioesters with the activity decreasing when the length of the carboxylic acid chain exceeds four carbons (By similarity) G4278_22110 ENOG4106YT9 Enoyl-CoA hydratase G4278_22120 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) G4278_22125 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein G4278_22130 ENOG4105P4Z Phage shock protein G G4278_22135 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) G4278_22140 ENOG4105MYN Zinc uptake regulation protein G4278_22145 ENOG4105VDW Csbd family G4278_22150 ENOG4107R73 Mate efflux family protein G4278_22160 ENOG41080IJ Diacylglycerol kinase G4278_22180 ENOG4107W52 maltose operon periplasmic protein G4278_22190 ENOG4108IJ9 (ABC) transporter G4278_22195 ENOG4107FKK extracellular solute-binding protein family 1 G4278_22200 ENOG4105D56 permease protein G4278_22205 ENOG4105EG2 ABC transporter, permease G4278_22220 ENOG4105E3R (LipO)protein G4278_22225 ENOG4108Q9C Periplasmic Protein G4278_22230 ENOG4108MDC (LipO)protein G4278_22245 ENOG4105CFH Aspartokinase G4278_22250 ENOG4108ZR5 Conserved Protein G4278_22255 ENOG4105FE9 pseudouridine synthase G4278_22260 ENOG4105DKT Transcriptional regulator G4278_22265 ENOG4105CHR reductase G4278_22270 ENOG4108XCU pts system G4278_22275 ENOG4105KPI PTS system sorbose subfamily IIB component G4278_22280 ENOG4105ETZ PTS System G4278_22285 ENOG4105F3R pts system mannose fructose sorbose family iid G4278_22290 ENOG4105DXH Alcohol dehydrogenase zinc-binding domain protein G4278_22295 ENOG4105EQ6 Hydrolyzes dipeptides containing N-terminal aspartate residues. May play a role in allowing the cell to use peptide aspartate to spare carbon otherwise required for the synthesis of the aspartate family of amino acids (By similarity) G4278_22300 ENOG4105EAM Na Pi-cotransporter G4278_22315 ENOG4105C3R Methionine synthase G4278_22320 ENOG41069M3 Transcriptional regulator G4278_22330 ENOG4108I9X Isocitrate lyase G4278_22335 ENOG4107QP3 malate synthase g G4278_22345 ENOG4105K5X acetyltransferase G4278_22350 ENOG41062WK cellular response to acidity G4278_22375 ENOG4105DC1 bifunctional purine biosynthesis protein purh G4278_22380 ENOG4105C12 Phosphoribosylglycinamide synthetase G4278_22385 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family G4278_22390 ENOG4105BZU Histidine kinase G4278_22395 ENOG4105JBU Binds zinc. Could be an important component of the zinc- balancing mechanism G4278_22400 ENOG4108T8B Protein of unknown function (DUF1481) G4278_22410 ENOG4105R2J Conserved Protein G4278_22430 ENOG4107MNS Has binding activity to the major sigma subunit of RNA polymerase. May be involved in replacement of the RNA polymerase sigma subunit from sigma-70 to sigma-S during the transition from exponential growth to the stationary phase (By similarity) G4278_22435 ENOG4105CBF Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction (By similarity) G4278_22440 ENOG4108UV6 Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP) (By similarity) G4278_22445 ENOG4105D06 uba thif-type nad fad binding protein G4278_22450 ENOG4105WHD thiamine biosynthesis protein ThiS G4278_22455 ENOG4105CA8 Catalyzes the rearrangement of 1-deoxy-D-xylulose 5- phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S (By similarity) G4278_22460 ENOG4105D41 biosynthesis protein thiH G4278_22495 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) G4278_22500 ENOG4105PM1 preprotein translocase subunit SecE G4278_22535 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase G4278_22540 ENOG4105D4A Cell wall formation (By similarity) G4278_22575 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) G4278_22585 ENOG4108Y73 Membrane G4278_22600 ENOG4105CH2 amidohydrolase G4278_22610 ENOG4105C5Q Transcriptional regulator G4278_22615 ENOG4108I5G Major Facilitator superfamily G4278_22620 ENOG4105CXK mandelate racemase muconate lactonizing G4278_22630 ENOG4105CAS nag kinase G4278_22635 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase G4278_22650 ENOG4105DIJ Phosphoethanolamine transferase G4278_22655 ENOG4106R3P AraC family transcriptional regulator G4278_22660 ENOG4108XCZ PTS System G4278_22665 ENOG4108AHH pyruvate formate lyase II activase G4278_22675 ENOG4108YRF PTS System G4278_22680 ENOG4105DM4 PTS System G4278_22685 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) G4278_22690 ENOG4107T9Z Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) G4278_22695 ENOG4105DCT glycerol dehydrogenase G4278_22700 ENOG4108XC3 NADH ubiquinone oxidoreductase G4278_22705 ENOG4108Q5Y Membrane G4278_22715 ENOG4105SYT Methylenetetrahydrofolate reductase G4278_22720 ENOG4105CGH 5'-nucleotidase G4278_22730 ENOG4105CGH 5'-nucleotidase G4278_22735 ENOG4105CGH 5'-nucleotidase G4278_22740 ENOG4105DRB nucleoside-specific channel-forming protein G4278_22745 ENOG4105CFH Aspartokinase G4278_22750 ENOG4105C28 cystathionine G4278_22760 ENOG4107S01 Repressor protein MetJ G4278_22770 ENOG4105C25 Primosomal protein n' G4278_22775 ENOG4105ETE Transcriptional regulator (LacI family G4278_22780 ENOG41063M6 Cell Division Protein G4278_22795 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase G4278_22810 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) G4278_22815 ENOG4108JQ0 Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) G4278_22820 ENOG4105CBT Fructose-1,6-bisphosphatase G4278_22825 ENOG4105DP0 ferredoxin-NADP reductase G4278_22835 ENOG41065TG regulatoR G4278_22840 ENOG4108VTS Membrane G4278_22845 ENOG4105EBK exported protein G4278_22860 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein G4278_22875 ENOG4105FMW periplasmic G4278_22880 ENOG4105E3W Two component transcriptional regulator (Winged helix family G4278_22885 ENOG4105E0F Histidine kinase G4278_22890 ENOG4108RPX mosc domain containing protein G4278_22900 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) G4278_22915 ENOG4107S4Z Activates expression of the rhaBAD and rhaT operons (By similarity) G4278_22925 ENOG4105DKG l-rhamnose isomerase G4278_22930 ENOG4105C9J Catalyzes the reversible cleavage of L-rhamnulose-1- phosphate to dihydroxyacetone phosphate (DHAP) and L-lactaldehyde (By similarity) G4278_22950 ENOG4107H9G Necessary for formate dehydrogenase activity (By similarity) G4278_22960 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein G4278_22965 ENOG4108MG3 formate dehydrogenase G4278_22990 ENOG4105W2W Cytotoxic translational repressor of toxin-antitoxin stability system G4278_23000 ENOG4105SUU thioesterase domain G4278_23015 ENOG4105EJU HAD-superfamily hydrolase subfamily IA variant 3 G4278_23025 ENOG4105CSH Transporter G4278_23035 ENOG4105CPQ Dehydrogenase G4278_23040 ENOG4105D2M Aldolase G4278_23045 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase G4278_23050 ENOG4108MGF sugar kinase G4278_23055 ENOG4105E98 transcriptional regulator DeoR family G4278_23060 ENOG4105R9B Major Facilitator G4278_23065 ENOG4108KHF Resistance protein G4278_23070 ENOG4108K85 Transcriptional regulator G4278_23075 ENOG4105CI3 gtp-binding protein typa G4278_23080 ENOG4105C5F glutamine synthetase G4278_23085 ENOG4105CUX Signal transduction histidine kinase G4278_23090 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family G4278_23095 ENOG4106FIY G4278_23100 ENOG4105D4P Coproporphyrinogen iii oxidase G4278_23105 ENOG4105ZR3 A GTPase-activating protein (GAP) that modifies Der EngA GTPase function. May play a role in ribosome biogenesis (By similarity) G4278_23115 ENOG4105C2M dna polymerase I G4278_23125 ENOG4106HNH Acyl-transferase G4278_23135 ENOG4108Z33 Thiol disulfide Interchange Protein G4278_23140 ENOG4105E27 serine threonine protein kinase G4278_23145 ENOG4105PC1 Conserved Protein G4278_23150 ENOG4105C6R Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) G4278_23155 ENOG4105FNP Molybdopterin-guanine dinucleotide biosynthesis protein b G4278_23180 ENOG4108RR8 protoporphyrinogen oxidase G4278_23185 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) G4278_23190 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein G4278_23200 ENOG4108EIM Catalyzes the formation of a hydroxyacyl-CoA by addition of water on enoyl-CoA. Also exhibits 3-hydroxyacyl-CoA epimerase and 3-hydroxyacyl-CoA dehydrogenase activities (By similarity) G4278_23205 ENOG4105CHU acetyl-coa acetyltransferase G4278_23210 ENOG4108EX3 reductase G4278_23215 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) G4278_23220 ENOG4105MDZ Transcriptional activator rfaH G4278_23230 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) G4278_23235 ENOG4105X8U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity) G4278_23240 ENOG4105WKS Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) G4278_23250 ENOG4105JC1 sterol-binding domain protein G4278_23260 ENOG4105CGY Dna recombination protein G4278_23265 ENOG4107HP6 Transcriptional regulator G4278_23270 ENOG4105EI3 2-dehydro-3-deoxygalactonokinase EC 2.7.1.58 G4278_23275 ENOG4108RTU Aldolase G4278_23280 ENOG4105JN3 extra-cytoplasmic solute receptor family protein G4278_23295 ENOG4108I5U Uridine phosphorylase G4278_23300 ENOG4105CDZ Carboxymethylenebutenolidase (EC 3.1.1.45) G4278_23305 ENOG4106XMA In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2 (By similarity) G4278_23315 ENOG4107R1Q Membrane protein FdrA G4278_23320 ENOG4107REC cytoplasmic protein G4278_23325 ENOG4105C5B carbamate kinase G4278_23335 ENOG4105DQW permease for cytosine purines, uracil, thiamine, allantoin G4278_23340 ENOG4105F52 Transcriptional regulator G4278_23345 ENOG4106KNT transcriptional regulator G4278_23350 ENOG4105CV1 Transketolase (EC 2.2.1.1) G4278_23365 ENOG4105GMB type VI secretion system effector, hcp1 family G4278_23370 ENOG4105GMB type VI secretion system effector, hcp1 family G4278_23380 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) G4278_23385 ENOG4105DZ2 Transcriptional regulator G4278_23390 ENOG4105EMK carboxylate amino acid amine transporter G4278_23395 ENOG4105DQF Hydrolase G4278_23400 ENOG4108EUD Lysophospholipase G4278_23405 ENOG410829K Lysine exporter protein (Lyse ygga) G4278_23410 ENOG4105CCF Lysine exporter protein (Lyse ygga) G4278_23415 ENOG4105C9U ATP-dependent DNA helicase RecQ G4278_23420 ENOG4105HDD phospholipase G4278_23425 ENOG4108VUY thioesterase Superfamily protein G4278_23430 ENOG4105FR1 rard protein G4278_23445 ENOG4107QUT magnesium and cobalt transport protein CorA G4278_23450 ENOG4108T58 Mg2 transport protein CorA G4278_23455 ENOG4107V4F S-adenosyl-l-methionine hydroxide adenosyltransferase G4278_23460 ENOG4105C4R Atp-dependent dna helicase G4278_23465 ENOG4105DFC had-superfamily hydrolase, subfamily ia, variant G4278_23475 ENOG4105CT0 Protein of unknown function, DUF484 G4278_23480 ENOG4105E4Z Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan (By similarity) G4278_23485 ENOG4105S7Z (LipO)protein G4278_23500 ENOG4105XQ6 frataxin-like protein G4278_23505 ENOG4107T0K Adenylate cyclase G4278_23510 ENOG4105D6W Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps (By similarity) G4278_23515 ENOG41076E6 Uroporphyrinogen-III Synthase G4278_23520 ENOG4105ECF c-methyltransferase G4278_23525 ENOG410601J HemY protein G4278_23530 ENOG4105ENH Sulfatase G4278_23535 ENOG4105C4X radical SAM domain protein G4278_23560 ENOG4105C85 amino acid G4278_23575 ENOG4105F18 Catalyzes the synthesis of Und-PP-GlcNAc-ManNAcA-Fuc4NAc (Lipid III), the third lipid-linked intermediate involved in ECA synthesis (By similarity) G4278_23580 ENOG4105EGZ biosynthesis protein G4278_23585 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase G4278_23590 ENOG4108WJ1 acetyltransferase G4278_23595 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) G4278_23600 ENOG4105C1B dTDP-glucose 4-6-dehydratase G4278_23605 ENOG4107QQG Dehydrogenase G4278_23610 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase G4278_23615 ENOG4105SFE lipopolysaccharide biosynthesis protein G4278_23620 ENOG4105ESV Glycosyl transferase, family 4 G4278_23625 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) G4278_23650 ENOG4105C4R Atp-dependent dna helicase G4278_23655 ENOG4105KQ5 peptidylprolyl cis-trans isomerase G4278_23665 ENOG4105EMY transcriptional regulator G4278_23670 ENOG4105C7B Threonine dehydratase G4278_23675 ENOG4105C01 Dihydroxy-acid dehydratase G4278_23680 ENOG4105CM2 brancheD-chain amino acid aminotransferase G4278_23685 ENOG4105P3Y Acetolactate synthase 2 regulatory subunit G4278_23705 ENOG4105C0P Mg chelatase subunit ChlI G4278_23710 ENOG4108WFC UPF0438 protein yifE G4278_23750 ENOG4107EJG GntR family transcriptional regulator G4278_23755 ENOG4105C0R drug resistance transporter emrb qaca subfamily G4278_23760 ENOG4105ETE Transcriptional regulator (LacI family G4278_23765 ENOG4108RVA ribokinase G4278_23770 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator G4278_23775 ENOG4105CNN ABC, transporter G4278_23780 ENOG4105C2J ABC transporter G4278_23785 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) G4278_23795 ENOG4107R4Q Functions as an ATPase. May play a role in metal insertion (metal-chelatase) or as a chaperone (By similarity) G4278_23810 ENOG4108VVK transcriptional Regulator, AsnC G4278_23815 ENOG4105QTB Flavodoxin G4278_23830 ENOG4105GXX Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit I associates with the membrane and may be involved with cation translocation G4278_23875 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) G4278_23880 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) G4278_23885 ENOG4107QMV Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity) G4278_23890 ENOG4105C8U phosphate abc transporter G4278_23895 ENOG4105E2Z phosphate ABC transporter (Permease G4278_23900 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) G4278_23905 ENOG4108UTW Plays a role in the regulation of phosphate uptake G4278_23910 ENOG4105CID antiterminator G4278_23915 ENOG4105C5Y PTS System G4278_23920 ENOG4105CS2 ec 3.2.1.21 G4278_23925 ENOG4108P68 Outer membrane porin G4278_23930 ENOG4105DYC esterase G4278_23935 ENOG4107VKM 6-phosphogluconolactonase G4278_23940 ENOG4106HGK Inner membrane protein yieI G4278_23945 ENOG4107UB3 HAD-superfamily hydrolase subfamily IA variant 3 G4278_23950 ENOG4105C7N Xanthine uracil vitamin C permease G4278_23955 ENOG4108YYH Nadph-dependent fmn reductase G4278_23960 ENOG4105E8Q phosphopantetheinyl transferase G4278_23965 ENOG4105G2Y Transcriptional regulator G4278_23975 ENOG4108P6C Tryptophan transporter of low affinity G4278_23980 ENOG4105C0F tryptophanase EC 4.1.99.1 G4278_24010 ENOG4105VG0 50S ribosomal protein l34 G4278_24060 ENOG4105EKQ RNA-directed DNA polymerase G4278_24105 ENOG41063SR receptor G4278_24140 ENOG4105EKQ RNA-directed DNA polymerase G4278_24160 ENOG4108YXQ IS66 Orf2 family protein G4278_24165 ENOG4105E5H Transposase G4278_24210 ENOG4105E0A ABC, transporter G4278_24215 ENOG4105EHG Permease protein G4278_24235 ENOG4108NKV transcriptional regulator G4278_24240 ENOG4108ZK4 sdia-regulated domain-containing protein G4278_24290 ENOG4105EKQ RNA-directed DNA polymerase G4278_24300 ENOG4105I1J Autotransporter G4278_24325 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) G4278_24330 ENOG4107R39 (ABC) transporter G4278_24335 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) G4278_24350 ENOG4107SJW iron permease, FTR1 G4278_24355 ENOG4106I92 NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity) G4278_24360 ENOG4108BUD transposase G4278_24410 ENOG4108BUD transposase G4278_24435 ENOG4105BZU Histidine kinase G4278_24455 ENOG4108BUD transposase G4278_24465 ENOG4107CBI conjugal transfer fertility inhibition protein G4278_24695 ENOG41074AV Hok/gef family G4278_24715 ENOG4105FEQ ParB domain protein nuclease G4278_24780 ENOG4106JQ7 G4278_24785 ENOG41073YN Protein of unknown function (DUF1380) G4278_24820 ENOG4106RMF ParB family