locus-tag class description EYD11_00010 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) EYD11_00020 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) EYD11_00025 ENOG4105VP5 Bacterial protein of unknown function (DUF937) EYD11_00030 ENOG410667J hydrolase EYD11_00035 ENOG410657R replicase EC 2.7 EYD11_00040 ENOG4105EMF GntR family transcriptional regulator EYD11_00045 ENOG4105EI3 2-dehydro-3-deoxygalactonokinase EC 2.7.1.58 EYD11_00050 ENOG4108RTU Aldolase EYD11_00060 ENOG4105DJB Major Facilitator Superfamily EYD11_00065 ENOG4107WAP fad NAD(P)-binding domain EYD11_00070 ENOG4105D99 atp gtp-binding protein EYD11_00075 ENOG4105R2A (LipO)protein EYD11_00095 ENOG4105FDP GntR family transcriptional regulator EYD11_00100 ENOG4105CI1 PTS System EYD11_00110 ENOG4108AHD Transcriptional regulator EYD11_00115 ENOG4107RUZ Sss sodium solute transporter superfamily EYD11_00120 ENOG4105CBG Sulfatase EYD11_00125 ENOG4106DRA Inner membrane protein YidI EYD11_00130 ENOG4105VG5 Membrane EYD11_00135 ENOG4105JP4 Inner membrane protein yidG EYD11_00140 ENOG4105J13 transcriptional regulator EYD11_00145 ENOG4105E5M Multidrug resistance protein D EYD11_00165 ENOG4105C7K acetolactate synthase EYD11_00170 ENOG4105M71 acetolactate synthase 1 regulatory subunit EYD11_00175 ENOG4108KX4 response regulator EYD11_00180 ENOG4105BZU Histidine kinase EYD11_00185 ENOG4105CXY transporter EYD11_00190 ENOG4105CXY transporter EYD11_00200 ENOG4105C7N Xanthine uracil vitamin C permease EYD11_00205 ENOG4108SAJ Protein of unknown function (DUF1198) EYD11_00215 ENOG4105T8A Uncharacterized protein YicS EYD11_00220 ENOG4105D01 (LipO)protein EYD11_00225 ENOG4108UZ3 Transporter EYD11_00230 ENOG4105S8Q sugar efflux transporter EYD11_00245 ENOG4105CT4 transporter EYD11_00250 ENOG4105CJQ hydrolase, family 31 EYD11_00255 ENOG4105JV1 AsmA family EYD11_00260 ENOG4105C2W permease EYD11_00265 ENOG4105D6U Sodium Glutamate Symporter EYD11_00270 ENOG4105CB5 ATP-dependent DNA helicase recG EYD11_00275 ENOG4105FE8 tRNA (Guanosine-2'-O-)-methyltransferase EYD11_00280 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) EYD11_00285 ENOG4105VFG Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits (By similarity) EYD11_00290 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) EYD11_00295 ENOG410649J Catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction (By similarity) EYD11_00300 ENOG4105EN6 Membrane EYD11_00305 ENOG4105F5P DNA-damage-inducible protein d EYD11_00315 ENOG4105DSJ YicC domain protein EYD11_00340 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase EYD11_00355 ENOG4105W0E 50S ribosomal protein L33 EYD11_00370 ENOG4105D8A 3-Deoxy-D-manno-octulosonic-acid transferase EYD11_00375 ENOG4105DKP glycosyl transferase, family 9 EYD11_00380 ENOG4107RJ7 Glycosyl transferase (Group 1 EYD11_00385 ENOG4107543 (lipo)polysaccharide EYD11_00390 ENOG4105X1N Glycosyl transferase family 8 EYD11_00395 ENOG4107XU6 Glycosyl transferase (Group 1 EYD11_00400 ENOG4106AH0 Glycosyl Transferase EYD11_00405 ENOG4105X1N Glycosyl transferase family 8 EYD11_00410 ENOG4108PDR lipopolysaccharide core biosynthesis protein EYD11_00415 ENOG4108QD8 lipopolysaccharide core biosynthesis protein EYD11_00420 ENOG4107XB0 Lipopolysaccharide 1,2-N-acetylglucosaminetransferase EYD11_00425 ENOG4108FRV O-antigen ligase EYD11_00430 ENOG4105D16 lipopolysaccharide heptosyltransferase i EYD11_00435 ENOG4105XA0 heptosyltransferase ii EYD11_00445 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) EYD11_00455 ENOG4105K64 Glycosyl transferase, family 2 EYD11_00460 ENOG4105PXI polysaccharide deacetylase EYD11_00465 ENOG41063SB peptidase EYD11_00480 ENOG4107YZP Rhodanese domain protein EYD11_00485 ENOG4105VW4 glutaredoxin 3 EYD11_00500 ENOG4105D7W serine acetyltransferase EYD11_00505 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) EYD11_00515 ENOG41073TP transcriptional regulator EYD11_00520 ENOG4105DAA L-lactate EYD11_00525 ENOG4108YYI Protein of unknown function (DUF2810) EYD11_00535 ENOG4105E61 Mannitol repressor protein EYD11_00545 ENOG4105CTS PTS system mannitol-specific EYD11_00550 ENOG4105FP6 Protein of unknown function (DUF3302) EYD11_00555 ENOG4105EFX secretion protein, HlyD family EYD11_00590 ENOG4105NUP lyase containing HEAT-repeat EYD11_00595 ENOG4105CNA YD repeat protein EYD11_00600 ENOG4108U78 Glutathione S-transferase EYD11_00610 ENOG4105EM7 Selenocysteine-specific translation elongation factor EYD11_00615 ENOG4105C0A alcohol dehydrogenase EYD11_00620 ENOG4105C26 Dehydrogenase EYD11_00630 ENOG4105KK7 inner membrane protein YiaW EYD11_00635 ENOG4105EFX secretion protein, HlyD family EYD11_00640 ENOG4108Q2M Transcriptional regulator EYD11_00645 ENOG4105GNX MltA-interacting MipA family protein EYD11_00655 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase EYD11_00660 ENOG41064BZ L-xylulose 5-phosphate 3-epimerase EYD11_00665 ENOG4105H6Q decarboxylase EYD11_00670 ENOG4105CMG Carbohydrate kinase EYD11_00675 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit EYD11_00680 ENOG4105CG6 trap dicarboxylate transporter dctm subunit EYD11_00685 ENOG4105XDZ Tripartite ATP-independent periplasmic transporter EYD11_00690 ENOG4108R66 Conserved Protein EYD11_00700 ENOG4105J4Q Transcriptional regulator EYD11_00705 ENOG4108XIB electron transport protein ysaA EYD11_00710 ENOG4105JKW Valine--pyruvate aminotransferase EYD11_00715 ENOG4107T9C Alpha amylase catalytic region EYD11_00720 ENOG4108UR8 BAX protein EYD11_00725 ENOG4105T16 Transcriptional regulator (AraC family) EYD11_00730 ENOG4107RNG ABC transporter EYD11_00735 ENOG4105C2J ABC transporter EYD11_00740 ENOG4105DFW ABC transporter EYD11_00750 ENOG4105CMG Carbohydrate kinase EYD11_00755 ENOG410688U Inner membrane protein yiaB EYD11_00760 ENOG4108Z12 YiaAB two helix domain-containing protein EYD11_00765 ENOG4105MEV Acyl-transferase EYD11_00770 ENOG4105RGS lipoprotein ysaB EYD11_00775 ENOG4108HMW glycyl-tRNA synthetase, alpha subunit EYD11_00790 ENOG41060TC Hok gef cell toxic protein EYD11_00795 ENOG4105VEQ Cold shock protein EYD11_00800 ENOG4105MVF Transcriptional regulator EYD11_00805 ENOG4106JH6 (LipO)protein EYD11_00815 ENOG4108ZG0 Ompa motb domain protein EYD11_00820 ENOG4107QY8 reductase EYD11_00825 ENOG4105HNP -acetyltransferase EYD11_00830 ENOG4108R3E Dna-3-methyladenine glycosylase i EYD11_00835 ENOG4105EAX Putative lipase EYD11_00840 ENOG4105FCD Major Facilitator EYD11_00845 ENOG4105DIJ Phosphoethanolamine transferase EYD11_00855 ENOG4105DEF Extracellular solute-binding protein, family 5 EYD11_00865 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component EYD11_00870 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component EYD11_00875 ENOG4105C3U ABC transporter EYD11_00880 ENOG4108JQ7 (ABC) transporter EYD11_00885 ENOG4105C44 Serine transporter EYD11_00895 ENOG4105D1V cellulose synthase operon protein YhjU EYD11_00900 ENOG4105WQA Cellulose biosynthesis protein BcsF EYD11_00905 ENOG4105U74 cellulose biosynthesis protein BcsE EYD11_00910 ENOG410661M cytoplasmic protein EYD11_00920 ENOG4107QZ7 Cellulose synthase catalytic subunit EYD11_00925 ENOG4107EEX Cellulose synthase regulator protein EYD11_00930 ENOG4105K2Z endo-1,4-d-glucanase (EC 3.2.1.4) EYD11_00935 ENOG4105EJG cellulose synthase EYD11_00940 ENOG4105BZU Histidine kinase EYD11_00950 ENOG4105CS0 peptidase EYD11_00955 ENOG4107SS6 2-dehydro-3-deoxygluconokinase EYD11_00960 ENOG4105CMB EAL domain-containing protein EYD11_00965 ENOG41066T0 asmA family EYD11_00970 ENOG4105CSH Transporter EYD11_00975 ENOG4107H3J ribonuclease EYD11_00980 ENOG4105CBN LysR family transcriptional regulator EYD11_00985 ENOG4106S2D Transcriptional regulator EYD11_00990 ENOG4105E53 ec 3.2.1.28 EYD11_00995 ENOG4105CA0 peroxidase EYD11_01000 ENOG4105CVK Glutamate decarboxylase EYD11_01005 ENOG4108NKV transcriptional regulator EYD11_01010 ENOG4105D3F AraC Family Transcriptional Regulator EYD11_01015 ENOG4105BZS acriflavin resistance protein EYD11_01020 ENOG4105C1P efflux transporter, rnd family, mfp subunit EYD11_01030 ENOG4106WJ0 Regulates the expression of several genes involved in acid resistance. Required for the expression of gadA and gadBC, among others, regardless of media or growth conditions. Binds directly to the 20 bp GAD box found in the control regions of both loci EYD11_01035 ENOG4108YK4 Acid-resistance membrane protein EYD11_01040 ENOG41060V2 Acid-resistance protein EYD11_01045 ENOG4105XXV Acid-resistance protein EYD11_01050 ENOG4105KT7 mgtC SapB transporter EYD11_01060 ENOG4105Y4Z Outer Membrane Lipoprotein EYD11_01070 ENOG4105K89 arsenate reductase EYD11_01075 ENOG4107R5R arsenical pump membrane protein EYD11_01080 ENOG4105KBH arsR family transcriptional regulator EYD11_01090 ENOG4105DC8 reductase EYD11_01095 ENOG4105D6S protein involved in catabolism of external DNA EYD11_01100 ENOG4105DGW oligopeptidase A EYD11_01105 ENOG4105FFN Specifically methylates the guanosine in position 1516 of 16S rRNA (By similarity) EYD11_01110 ENOG4105DUX Transporter EYD11_01115 ENOG4108M6U Universal stress protein A EYD11_01125 ENOG4105CJ3 phosphate transporter EYD11_01130 ENOG4105CBX hi0933 family EYD11_01135 ENOG4107UNS conserved inner membrane protein EYD11_01150 ENOG4105D0S secretion protein (HlyD EYD11_01155 ENOG4105CJ1 ABC, transporter EYD11_01160 ENOG4105CMI transporter EYD11_01165 ENOG410600T transposase EYD11_01170 ENOG4105NUP lyase containing HEAT-repeat EYD11_01180 ENOG4105CNA YD repeat protein EYD11_01190 ENOG4105EFJ Part of the ABC transporter complex NikABCDE involved in nickel import. Responsible for energy coupling to the transport system (By similarity) EYD11_01195 ENOG4106665 Part of the ABC transporter complex NikABCDE involved in nickel import. Responsible for energy coupling to the transport system (By similarity) EYD11_01200 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component EYD11_01205 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component EYD11_01210 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein EYD11_01215 ENOG4107YAK holo-(acyl carrier protein) synthase 2 EYD11_01220 ENOG4105DSF transport protein EYD11_01225 ENOG4105F9N Major Facilitator Superfamily EYD11_01230 ENOG4108W1V Lipoprotein EYD11_01235 ENOG4105EX9 Membrane EYD11_01245 ENOG4105C59 p-type ATPase EYD11_01250 ENOG4107FS9 Membrane EYD11_01260 ENOG4105MG3 Membrane EYD11_01265 ENOG4106H78 methyltransferase EYD11_01270 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) EYD11_01275 ENOG4105CAK Cell division ATP-binding protein ftsE EYD11_01280 ENOG4105CRP Part of the ABC transporter FtsEX involved in EYD11_01285 ENOG4105DEK Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) EYD11_01290 ENOG4105CP9 extracellular ligand-binding receptor EYD11_01295 ENOG4105U59 -acetyltransferase EYD11_01300 ENOG4105CP9 extracellular ligand-binding receptor EYD11_01305 ENOG4105C32 Amino acid ABC transporter (Permease) EYD11_01310 ENOG4105CF8 branched-chain amino acid ABC transporter, permease EYD11_01315 ENOG4105C0Z ABC transporter EYD11_01320 ENOG4108IV0 ABC, transporter EYD11_01325 ENOG4105BZ7 extracellular solute-binding protein family 1 EYD11_01330 ENOG4105E4X binding-protein-dependent transport systems inner membrane Component EYD11_01335 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component EYD11_01340 ENOG4108IJ9 (ABC) transporter EYD11_01345 ENOG4107T6V glycerophosphoryl diester phosphodiesterase EYD11_01355 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) EYD11_01360 ENOG4106FA4 EYD11_01380 ENOG4105GMB type VI secretion system effector, hcp1 family EYD11_01385 ENOG4105WCN acetyltransferase EYD11_01390 ENOG4105D9R oxidoreductase EYD11_01395 ENOG4105C2I pirin domain protein EYD11_01400 ENOG4105DIQ Transcriptional regulator EYD11_01405 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family EYD11_01410 ENOG4105C6Z Gluconate EYD11_01415 ENOG41076UM multiple antibiotic resistance (MarC)-related protein EYD11_01420 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) EYD11_01445 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) EYD11_01455 ENOG4105C6V Glycerol-3-phosphate dehydrogenase EYD11_01470 ENOG4105E98 transcriptional regulator DeoR family EYD11_01475 ENOG4105CYB regulatoR EYD11_01480 ENOG4105E0Y RtcB Protein EYD11_01495 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) EYD11_01500 ENOG4107RTM 4-alpha-glucanotransferase (EC 2.4.1.25) EYD11_01505 ENOG4105C6Z Gluconate EYD11_01515 ENOG4105MJ2 Competence protein EYD11_01525 ENOG4105DNE Transposase EYD11_01535 ENOG4105CE1 Ferrous iron transport protein b EYD11_01540 ENOG4105XFK Ferrous iron transport protein A EYD11_01545 ENOG4105BZM domain protein EYD11_01550 ENOG4108RRZ Transcription elongation factor GreB EYD11_01555 ENOG4105DPZ Two component transcriptional regulator (Winged helix family EYD11_01560 ENOG4105E0F Histidine kinase EYD11_01570 ENOG4108MAJ Membrane EYD11_01580 ENOG4105VEJ Heat shock protein EYD11_01585 ENOG4107Y3D HAD-superfamily hydrolase subfamily IA variant 3 EYD11_01590 ENOG4105DQY intracellular growth attenuator EYD11_01595 ENOG4107RK2 ADP-ribose diphosphatase NudE EYD11_01600 ENOG4108JQC penicillin-binding protein 1A EYD11_01605 ENOG4108U1Q Pilus assembly protein EYD11_01610 ENOG41065NF Fimbrial assembly family protein EYD11_01615 ENOG4105XPX DNA utilization protein HofO EYD11_01620 ENOG4105ITY Required for the use of extracellular DNA as a nutrient EYD11_01625 ENOG4105E4G Type IV pilus EYD11_01640 ENOG4105EGB membrane protein DamX EYD11_01645 ENOG4105DFE Dna adenine methylase EYD11_01650 ENOG4105DJV ribulose-phosphate 3-epimerase EYD11_01655 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) EYD11_01660 ENOG4105C31 Tryptophanyl-tRNA synthetase EYD11_01670 ENOG4108M21 EYD11_01675 ENOG4105RMW regulation of transcription, DNA-dependent EYD11_01680 ENOG4108626 Racemase EYD11_01685 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) EYD11_01690 ENOG41080QX K07048 phosphotriesterase-related protein EYD11_01695 ENOG4105MUZ Protein of unknown function DUF2620 EYD11_01700 ENOG4106M0N transport system permease protein EYD11_01705 ENOG4106PKC pyridoxal phosphate binding EYD11_01710 ENOG4105FDP GntR family transcriptional regulator EYD11_01715 ENOG4108KPW sugar kinase EYD11_01720 ENOG4107Y0V Not clear, may be involved in an isomerization step EYD11_01725 ENOG4107R1S catalyzes the conversion of fructoselysine 6-phosphate to glucose 6-phosphate and lysine EYD11_01730 ENOG4107QHQ amino acid EYD11_01735 ENOG4105VYH EYD11_01745 ENOG4107V9H nitrite transporter EYD11_01750 ENOG4105WZK nitrite reductase NADPH small subunit EYD11_01755 ENOG4107QZF nitrite reductase NADPH large subunit EYD11_01765 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) EYD11_01770 ENOG4106195 uncharacterized protein yhfG EYD11_01775 ENOG4105MZU cell filamentation protein EYD11_01780 ENOG4105DDQ anthranilate synthase EYD11_01785 ENOG4105C8Y Acetylornithine aminotransferase EYD11_01790 ENOG410613R integral membrane protein, YccS YhfK family EYD11_01795 ENOG4107RYR Transcriptional regulator, Crp Fnr family EYD11_01800 ENOG4108UKZ OsmC family EYD11_01805 ENOG4105CJE phosphoribulokinase (EC 2.7.1.19) EYD11_01815 ENOG4105DNZ Alpha Beta Hydrolase EYD11_01820 ENOG4105C5H ABC transporter EYD11_01835 ENOG4105VKU nucleicacid-binding protein EYD11_01840 ENOG4108YZY peptidylprolyl cis-trans isomerase EYD11_01850 ENOG4108V1T peptidylprolyl cis-trans isomerase EYD11_01855 ENOG4105WWK YheO domain protein EYD11_01895 ENOG4108NNZ chitinase EYD11_01900 ENOG4105W53 bacterioferritin-associated ferredoxin EYD11_01905 ENOG4108UQY Iron-storage protein EYD11_01910 ENOG4105EHH Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue (By similarity) EYD11_01920 ENOG41063JA Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins (By similarity) EYD11_01925 ENOG4105R04 type II secretion system protein K EYD11_01940 ENOG41069X0 general secretion pathway protein h EYD11_01945 ENOG4108VAU general secretion pathway protein G EYD11_01950 ENOG4105D7Q type ii secretion system EYD11_01955 ENOG4107QHF type ii secretion system protein e EYD11_01960 ENOG4105GVR general secretion pathway protein D EYD11_01965 ENOG4107KSE General secretion pathway protein C EYD11_01970 ENOG410899B May play a regulatory role under conditions of derepressed gsp gene expression EYD11_01975 ENOG4107ACA Calcium-binding protein required for initiation of chromosome replication EYD11_01990 ENOG4106U5A One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity) EYD11_01995 ENOG41080KG One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) EYD11_02005 ENOG4105K7S Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity) EYD11_02010 ENOG4105KAP The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity) EYD11_02015 ENOG4105CKE Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity) EYD11_02020 ENOG4108R70 Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs (By similarity) EYD11_02030 ENOG4105K87 One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal EYD11_02040 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) EYD11_02055 ENOG4108UJY One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity) EYD11_02065 ENOG4105K4C This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity) EYD11_02070 ENOG4108RA9 Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity) EYD11_02085 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) EYD11_02090 ENOG41067V7 50S ribosomal protein L36 EYD11_02095 ENOG4108Z04 Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits EYD11_02105 ENOG4105G6W One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit (By similarity) EYD11_02110 ENOG4105CTF DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity) EYD11_02120 ENOG4105VTS DnaJ-like, subfamily C EYD11_02125 ENOG4105W1Y Transcriptional regulator EYD11_02130 ENOG4105VCN Rescues the ribosomes stalled at the 3' end of non-stop mRNAs. May induce hydrolysis of the ribosome-bound peptidyl-tRNA. This activity is crucial when the stalled ribosome can not be rescued by the SsrA(tmRNA)-SmpB quality control system EYD11_02140 ENOG4105C1A potassium transporter peripheral membrane EYD11_02160 ENOG4105C79 DNA protecting protein DprA EYD11_02170 ENOG4108WI1 Dna topoisomerase EYD11_02175 ENOG4105EK0 Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) EYD11_02185 ENOG4105SG3 Protein of unknown function (DUF1488) EYD11_02190 ENOG4108Z0R Transferase EYD11_02230 ENOG4105CDA abc transporter atp-binding protein EYD11_02235 ENOG4105DRP amino acid AbC transporter EYD11_02240 ENOG4105EZ7 amino acid ABC transporter EYD11_02250 ENOG4105XCM membrane LIPOPROTEIN EYD11_02255 ENOG4105BZS acriflavin resistance protein EYD11_02275 ENOG4105CEC DNA methylase N-4 N-6 EYD11_02280 ENOG4105VY0 Activates ribosomal RNA transcription. Plays a direct role in upstream activation of rRNA promoters (By similarity) EYD11_02285 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) EYD11_02295 ENOG4108IA2 Sodium pantothenate symporter EYD11_02300 ENOG4105RG0 Membrane EYD11_02305 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase EYD11_02310 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein EYD11_02315 ENOG4105D3Z quinone oxidoreductase, yhdh yhfp family EYD11_02320 ENOG41062P1 Diguanylate cyclase phosphodiesterase EYD11_02330 ENOG4105DFF Rod shape-determining protein mreb EYD11_02335 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) EYD11_02340 ENOG4105VQ7 Rod shape-determining protein MreD EYD11_02345 ENOG4108Z03 MAF-like protein EYD11_02350 ENOG4105C03 ribonuclease EYD11_02355 ENOG4105QD6 exported protein EYD11_02360 ENOG4105D1U peptidase U62 modulator of DNA gyrase EYD11_02365 ENOG4105CR8 Transcriptional regulator EYD11_02385 ENOG4105UNR (Barnase) inhibitor EYD11_02390 ENOG4105RID UPF0379 protein yhcN EYD11_02405 ENOG4105C0H protease EYD11_02410 ENOG4105C0H protease EYD11_02415 ENOG4108W2Q Cytochrome d ubiquinol oxidase subunit III EYD11_02420 ENOG4105D6Z AFG1 family ATPase EYD11_02430 ENOG4108UJD 30S ribosomal protein S9 EYD11_02435 ENOG4107MKT Stringent starvation protein a EYD11_02440 ENOG4105KB2 stringent starvation protein b EYD11_02445 ENOG4105CEE C4-dicarboxylate transporter EYD11_02475 ENOG4108R66 Conserved Protein EYD11_02480 ENOG4105DFS Conserved Protein EYD11_02495 ENOG4105EKQ RNA-directed DNA polymerase EYD11_02510 ENOG4105UMR response to DNA damage stimulus EYD11_02520 ENOG4105E6S usher protein( EYD11_02525 ENOG4108S1B Periplasmic chaperone protein EYD11_02530 ENOG4106AJS Involved in induction of the so-called NTR enzymes in response to nitrogen deprivation, as well as in glutamate biosynthesis. May mediate the glutamate-dependent repression of the GLT operon EYD11_02535 ENOG4105BZ8 glutamate synthase EYD11_02540 ENOG4105CBC glutamate synthase EYD11_02545 ENOG4105N5T Radical SAM Protein EYD11_02550 ENOG4105BZU Histidine kinase EYD11_02555 ENOG4108556 Isoprenoid biosynthesis protein with amidotransferase-like domain EYD11_02565 ENOG4108NIH transferase activity, transferring phosphorus-containing groups EYD11_02570 ENOG41080Z8 PHOSPHOCARRIER protein EYD11_02580 ENOG4107RM2 PTS IIA-like nitrogen-regulatory protein PtsN EYD11_02585 ENOG41080QH sigma 54 modulation protein ribosomal protein S30EA EYD11_02590 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) EYD11_02595 ENOG4108IUZ ABC transporter EYD11_02600 ENOG4105WI0 lipopolysaccharide transport periplasmic protein lptA EYD11_02605 ENOG4108P1K Required for the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane (By similarity) EYD11_02610 ENOG4108Z4R 3-deoxy-d-manno-octulosonate 8-phosphate phosphatase EYD11_02615 ENOG4105C2X Arabinose 5-phosphate isomerase EYD11_02620 ENOG4105FEU K -dependent Na -Ca exchanger EYD11_02625 ENOG4105DHJ ABC, transporter EYD11_02630 ENOG4105CY3 ABC transporter, permease EYD11_02635 ENOG4107PE3 Mammalian cell entry related domain protein EYD11_02640 ENOG4105E3I toluene tolerance EYD11_02645 ENOG4105UE2 Part of the ABC transporter complex MlaFEDB that actively prevents phospholipid accumulation at the cell surface. Probably maintains lipid asymmetry in the outer membrane by retrograde trafficking of phospholipids from the outer membrane to the inner membrane EYD11_02650 ENOG4105VFK BolA family EYD11_02660 ENOG4105HVQ Regulatory factor of maltose metabolism EYD11_02665 ENOG4105EAH synthase EYD11_02680 ENOG4105QYV Membrane EYD11_02685 ENOG4105C9R An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control EYD11_02690 ENOG4106HRJ d-alanyl-d-alanine carboxypeptidase EYD11_02695 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) EYD11_02700 ENOG4105HBR Rna-binding protein EYD11_02705 ENOG4105F7M Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit (By similarity) EYD11_02710 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) EYD11_02715 ENOG4105EEI dihydropteroate synthase EYD11_02735 ENOG4105DIJ Phosphoethanolamine transferase EYD11_02755 ENOG4105CHV Transcription elongation factor NusA EYD11_02770 ENOG4105D0T Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity) EYD11_02785 ENOG4105RT1 May be involved in cell division (By similarity) EYD11_02795 ENOG4105C1J atp-dependent rna helicase EYD11_02800 ENOG4105CIC tryptophan-specific transport protein EYD11_02805 ENOG4105DEN Luciferase family EYD11_02810 ENOG4106RZ4 Peptidase U32 EYD11_02815 ENOG4105CFP Peptidase U32 EYD11_02820 ENOG4105XPQ lipid carrier protein EYD11_02825 ENOG4108YYD acetyltransferase EYD11_02840 ENOG4107R7Y intracellular protease Pfpi family EYD11_02845 ENOG4105K4T epimerase EYD11_02850 ENOG4107S21 permease EYD11_02855 ENOG4105W4M Transport-associated protein EYD11_02860 ENOG4105F55 Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate (By similarity) EYD11_02870 ENOG4105E1C Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1A (PBP1a) (By similarity) EYD11_02875 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) EYD11_02880 ENOG4105I74 Fimbrial protein EYD11_02885 ENOG4105CW0 outer membrane usher protein EYD11_02890 ENOG4108VCD Chaperone EYD11_02895 ENOG4105Q10 Fimbrial-like protein EYD11_02900 ENOG4106HBN Galactosamine-6-phosphate isomerase EYD11_02905 ENOG4105F3R pts system mannose fructose sorbose family iid EYD11_02910 ENOG4105ETZ PTS System EYD11_02920 ENOG4108UZY PTS System EYD11_02930 ENOG4105E70 isomerase EYD11_02935 ENOG4105CE4 GlcNAc 6-P deacetylase EYD11_02940 ENOG4108YTN IIa component EYD11_02945 ENOG4105F3R pts system mannose fructose sorbose family iid EYD11_02955 ENOG4108RG5 PTS system N-acetylgalactosamine-specific transporter subunit IIB EYD11_02965 ENOG4105E98 transcriptional regulator DeoR family EYD11_02970 ENOG4108R8Z these effects are overcome by concomitant expression of antitoxin SohA (PrlF). Massive overexpression is toxic. Unlike most other characterized TA systems degrades rRNA, and co-folding of the proteins is necessary in vitro for inhibition of the RNase activity. It is not known if it has any sequence-specificity. Acts as a transcription factor. The YhaV PrlF complex binds the prlF-yhaV operon, probably negatively regulating its expression EYD11_02975 ENOG4105ZEG Suppressor protein EYD11_02980 ENOG4105CTX dehydratase EYD11_02985 ENOG4105DJB Major Facilitator Superfamily EYD11_02995 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase EYD11_03000 ENOG4105BZW Glycerate kinase EYD11_03025 ENOG410811B TRANSCRIPTIONal EYD11_03040 ENOG4105KAF membrAne EYD11_03045 ENOG4105CHF Glutathione S-transferase EYD11_03050 ENOG4108VBZ doxx family EYD11_03055 ENOG4105YJD EYD11_03060 ENOG41090KG Inner membrane protein YqjE EYD11_03065 ENOG4105NE1 Conserved Protein EYD11_03070 ENOG4105WAY exported protein EYD11_03075 ENOG4105IYR Modulates the activity of the EnvZ OmpR two-component regulatory system, probably by directly modulating EnvZ enzymatic activity and increasing stability of phosphorylated OmpR (By similarity) EYD11_03080 ENOG4106W5V Membrane EYD11_03085 ENOG4107YCY Transcriptional regulator EYD11_03090 ENOG4105DPW Major facilitator superfamily MFS_1 EYD11_03100 ENOG4105CTX dehydratase EYD11_03105 ENOG4105P66 Membrane EYD11_03110 ENOG4107QV7 Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system) (By similarity) EYD11_03115 ENOG4105DU1 integral membrane protein, terc EYD11_03120 ENOG4105EE0 oxidoreductase EYD11_03125 ENOG4108UB4 uncharacterized protein ygjQ EYD11_03130 ENOG4108VKG metal-dependent hydrolase EYD11_03135 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) EYD11_03140 ENOG4105R48 this blockage is overcome by subsequent expression of antitoxin HigA. Overexpression causes cleavage of a number of mRNAs in a translation-dependent fashion, suggesting this is an mRNA interferase EYD11_03145 ENOG4108Z3N Transcriptional regulator EYD11_03150 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase EYD11_03155 ENOG4107WCA isomerase EYD11_03160 ENOG4107W6W Conserved Protein EYD11_03165 ENOG4105E5D amino acid EYD11_03170 ENOG4105FK9 beta-D-galactosidase beta subunit EYD11_03175 ENOG4105CNT hydrolase family 2 EYD11_03180 ENOG4105CQ4 Transcriptional regulator EYD11_03185 ENOG4108Y51 tRNA-binding protein EYD11_03195 ENOG4107RHT methyl-accepting chemotaxis sensory transducer with Pas Pac sensor EYD11_03200 ENOG4105NTW Transcriptional regulator EYD11_03205 ENOG4105Q26 Siderophore-interacting protein EYD11_03220 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) EYD11_03225 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) EYD11_03230 ENOG4105VCC 30S ribosomal protein S21 EYD11_03240 ENOG4107QPK )-transporter EYD11_03245 ENOG4107GFK fumarate EYD11_03250 ENOG4106DSS Tartrate dehydratase subunit alpha EYD11_03255 ENOG4105EJC lysr family transcriptional regulator EYD11_03265 ENOG4107ZVW dihydroneopterin aldolase EYD11_03270 ENOG4105DWR Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity) EYD11_03280 ENOG4106MWK domain protein EYD11_03285 ENOG4105I7R Adenylate cyclase EYD11_03310 ENOG4107S78 Band 7 protein EYD11_03315 ENOG4105PV3 Inner membrane protein yqiJ EYD11_03325 ENOG4108MY7 Fimbrial EYD11_03330 ENOG4108TTM chaperone EYD11_03350 ENOG4105H8W Fimbrial protein EYD11_03355 ENOG4105W0Z cytoplasmic protein EYD11_03370 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b EYD11_03375 ENOG4106032 Glutathionylspermidine synthase EYD11_03385 ENOG4105DFG type I secretion outer membrane protein EYD11_03390 ENOG41087AY ADP-Ribose pyrophosphatase EYD11_03395 ENOG4108SX3 cytoplasmic protein EYD11_03400 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) EYD11_03405 ENOG4105IPS esterase EYD11_03410 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) EYD11_03415 ENOG4105VRH Antibiotic biosynthesis monooxygenase EYD11_03420 ENOG4105NF4 modulator of drug activity EYD11_03425 ENOG4107DEU Inner membrane protein YgiZ EYD11_03430 ENOG4105DHQ Histidine kinase EYD11_03435 ENOG4105XJC Two component transcriptional regulator (Winged helix family EYD11_03440 ENOG4105H4F exported protein EYD11_03445 ENOG4105F4I Transcriptional regulator EYD11_03450 ENOG4105RT5 Toxic component of a toxin-antitoxin (TA) module. An mRNA interferase which has been reported to be translation- independent (PubMed 19690171, PubMed 19943910) and translation- dependent (PubMed 20041169). Cleavage has been reported to occur on either side of G in the sequence GCU (PubMed 19690171) but also after C in GC(A U) sequences (PubMed 19943910). There are only 14 genes in E.coli W3110 (and probably also MG1655) that do not have a GCU sequence and thus are resistant to the mRNA interferase activity. Overexpression causes cessation of cell growth and inhibits cell proliferation via inhibition of translation as well as increasing persister cell formation EYD11_03455 ENOG4105WJ3 XRE family Transcriptional regulator EYD11_03460 ENOG4108J59 Extracellular solute-binding protein, family 5 EYD11_03465 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) EYD11_03470 ENOG4107S7E 1-acyl-sn-glycerol-3-phosphate acyltransferase EYD11_03475 ENOG4107TZ2 Cell division protein that is required for growth during stress conditions. May be involved in protecting or stabilizing the divisomal assembly under conditions of stress (By similarity) EYD11_03480 ENOG4105CCT upf0313 protein EYD11_03490 ENOG4105ZKC Conserved Protein EYD11_03495 ENOG4105CV8 reductase EYD11_03500 ENOG4108I6A alcohol dehydrogenase EYD11_03505 ENOG4105CF7 AraC family transcriptional regulator EYD11_03510 ENOG4108K81 inner membrane protein YghB EYD11_03515 ENOG4105C28 cystathionine EYD11_03520 ENOG4105CWK Biopolymer transport protein, ExbB EYD11_03525 ENOG4108ZZF transport protein (ExbD) EYD11_03530 ENOG4105CYX Short-chain dehydrogenase reductase Sdr EYD11_03540 ENOG4105CPC Aldo Keto reductase EYD11_03550 ENOG410900S Protein of unknown function (DUF2623) EYD11_03555 ENOG4105E3S small subunit EYD11_03560 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein EYD11_03565 ENOG4105CJ5 hydrogenase 2 b cytochrome subunit EYD11_03570 ENOG4105DPX Hydrogenase, large subunit EYD11_03575 ENOG4108USZ hydrogenase EYD11_03580 ENOG4108WGS hydrogenase 2-specific chaperone EYD11_03585 ENOG4105WMM Probably plays a role in a hydrogenase nickel cofactor insertion step (By similarity) EYD11_03590 ENOG41082MF Hydrogenase assembly chaperone hypC hupF EYD11_03595 ENOG4105CYM Glutathione S-transferase EYD11_03600 ENOG4106032 Glutathionylspermidine synthase EYD11_03605 ENOG4105CJ3 phosphate transporter EYD11_03610 ENOG4108GH0 ATP-binding protein yghT EYD11_03615 ENOG4108NDC ATP-binding protein yghS EYD11_03620 ENOG4106FPV ATP-binding protein YghR EYD11_03625 ENOG4108S55 polysaccharide biosynthesis protein EYD11_03635 ENOG4108UUE Transcriptional regulator EYD11_03640 ENOG4108M8S permease YjgP YjgQ family protein EYD11_03650 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) EYD11_03655 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) EYD11_03665 ENOG4107RCI amp-dependent synthetase and ligase EYD11_03675 ENOG4108KWP DNA-binding transcriptional regulator GlcC EYD11_03680 ENOG4105CQB FAD linked oxidase domain protein EYD11_03685 ENOG4105EU8 FAD linked oxidase domain protein EYD11_03690 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) EYD11_03695 ENOG4108ZJF Glcg protein EYD11_03700 ENOG4107QP3 malate synthase g EYD11_03705 ENOG4105DAA L-lactate EYD11_03710 ENOG4105F88 accessory colonization factor AcfD EYD11_03715 ENOG4105EHH Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue (By similarity) EYD11_03720 ENOG410765S (LipO)protein EYD11_03725 ENOG4108XKW General secretion pathway protein C EYD11_03740 ENOG4105D7Q type ii secretion system EYD11_03745 ENOG4108VAU general secretion pathway protein G EYD11_03755 ENOG4105X5Z General secretion pathway protein I EYD11_03775 ENOG4105U1E general secretion pathway protein M EYD11_03800 ENOG4105MAW Antitoxin component of a toxin-antitoxin (TA) module. Labile antitoxin that counteracts the effect of the CbtA (YeeV) toxin. It does not bind to the cognate toxin but instead binds to MreB and FtsZ (the toxin targets), enhancing their polymerization by forming higher-order bundles EYD11_03805 ENOG4106WJE Protein of unknown function (DUF987) EYD11_03810 ENOG4108YGG dna repair protein EYD11_03815 ENOG4106549 Antirestriction protein EYD11_03820 ENOG4106H6R UPF0380 protein EYD11_03835 ENOG4108KZE transcriptional regulator EYD11_03840 ENOG4105TS0 gtp-binding protein EYD11_03875 ENOG4105CAJ Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity) EYD11_03880 ENOG4105DD7 kinase (PfkB family EYD11_03885 ENOG4105D53 Catalyzes the hydrolysis of pseudouridine 5'-phosphate (PsiMP) to ribose 5-phosphate and uracil (By similarity) EYD11_03890 ENOG4105D9N nucleoside EYD11_03895 ENOG4105DD7 kinase (PfkB family EYD11_03940 ENOG4105KNY Microcompartments protein EYD11_03945 ENOG4105CPH Catalyzes the formation of S-adenosylmethionine from methionine and ATP EYD11_03950 ENOG4106R3P AraC family transcriptional regulator EYD11_03955 ENOG4105C2F Histidine kinase EYD11_03965 ENOG4105EKQ RNA-directed DNA polymerase EYD11_03985 ENOG4105F1A Pyruvate formate-lyase EYD11_03990 ENOG4105C6N Formate acetyltransferase EYD11_03995 ENOG4107R7Y intracellular protease Pfpi family EYD11_04005 ENOG4108EKI Dehydrogenase EYD11_04010 ENOG4105EHR propanediol utilization protein pduB EYD11_04015 ENOG4105KNY Microcompartments protein EYD11_04030 ENOG4105WVM ethanolamine utilization protein EutN carboxysome structural protein Ccml EYD11_04040 ENOG4107RWI ethanolamine utilization protein eutJ EYD11_04045 ENOG4108VPX Involved in 1,2-propanediol (1,2-PD) degradation by catalyzing the conversion of propanoyl-CoA to propanoyl-phosphate (By similarity) EYD11_04100 ENOG4105BZV Phosphoadenosine phosphosulfate reductase EYD11_04105 ENOG4105GTN ParB Domain Protein Nuclease EYD11_04125 ENOG4107QRT dEAD DEAH box helicase EYD11_04145 ENOG4105T40 surface antigen msp4 family protein EYD11_04150 ENOG4108I6E Sulfatase EYD11_04165 ENOG4108UQV Membrane EYD11_04170 ENOG4105CXN decarboxylase EYD11_04175 ENOG4105EAA nucleoside EYD11_04190 ENOG4105CEN a g-specific adenine glycosylase EYD11_04200 ENOG41090ED Protein with unknown function (DUF469) EYD11_04205 ENOG4105K33 Periplasmic Protein EYD11_04210 ENOG4105HDK L-asparaginase EYD11_04215 ENOG4106MH3 alpha helix chain EYD11_04220 ENOG4105CSA Coproporphyrinogen iii oxidase EYD11_04225 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) EYD11_04235 ENOG4108VIA integral membrane protein EYD11_04240 ENOG4105DFA alanine racemase domain protein EYD11_04245 ENOG4105CZX twitching motility protein EYD11_04260 ENOG4105D7Z glutathione synthase EYD11_04265 ENOG4105QF0 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) EYD11_04270 ENOG4105RWS endonuclease I EYD11_04280 ENOG4107QNK )-transporter EYD11_04305 ENOG4105DP5 Catalyzes the biosynthesis of agmatine from arginine (By similarity) EYD11_04315 ENOG4108K0D peptidase, M48 EYD11_04320 ENOG4105CV1 Transketolase (EC 2.2.1.1) EYD11_04325 ENOG4108X7Y Mannitol-specific cryptic phosphotransferase enzyme iia EYD11_04330 ENOG4105CTS PTS system mannitol-specific EYD11_04335 ENOG4105DXH Alcohol dehydrogenase zinc-binding domain protein EYD11_04340 ENOG4108Q8A Fructose-1,6-bisphosphatase EYD11_04345 ENOG4108R4K DNA-binding, transcriptional regulator EYD11_04350 ENOG4107Z1W Fructose transport system kinase EYD11_04365 ENOG4105D2N Aldolase EYD11_04370 ENOG4105D64 Mechanosensitive ion channel EYD11_04375 ENOG4108ZUB Lysine exporter protein (Lyse ygga) EYD11_04380 ENOG4105MPN Membrane EYD11_04385 ENOG4105DEQ transcriptional regulator EYD11_04390 ENOG4105CYC Transferase EYD11_04395 ENOG4108M7F enoyl-CoA hydratase isomerase EYD11_04400 ENOG4105DJT lAO AO transport system ATPase EYD11_04405 ENOG4105D5P Methylmalonyl-coA mutase EYD11_04425 ENOG4108JQ1 Dehydrogenase EYD11_04435 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase EYD11_04455 ENOG4107RAQ aminopeptidase EYD11_04460 ENOG4105D0A hydroxylase EYD11_04465 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family EYD11_04490 ENOG4105CYX Short-chain dehydrogenase reductase Sdr EYD11_04495 ENOG4105CS2 ec 3.2.1.21 EYD11_04500 ENOG4105N5Z UPF0267 protein EYD11_04505 ENOG4108UT2 hemolysin iii EYD11_04515 ENOG4105Y75 tpr repeat protein EYD11_04520 ENOG4108YDB Toxic component of a toxin-antitoxin (TA) module. Overexpression leads to growth arrest after 5 hours, with initial elongation of cells, followed by swelling. The toxic effects are abrogated by coexpression with antitoxin CptB. Interacts with cytoskeletal proteins FtsZ and MreB EYD11_04525 ENOG41071R3 Low-potential electron donor to a number of redox enzymes (By similarity) EYD11_04530 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) EYD11_04535 ENOG4105T95 Thiol disulfide interChange protein EYD11_04540 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) EYD11_04550 ENOG4105CRK lysyL-tRNA synthetase EYD11_04570 ENOG4105C2W permease EYD11_04575 ENOG4105BZ8 glutamate synthase EYD11_04580 ENOG4108R8B oxidoreductase Fe-S subunit EYD11_04585 ENOG4105C7N Xanthine uracil vitamin C permease EYD11_04590 ENOG4107QUY Guanine deaminase EYD11_04595 ENOG4105C2W permease EYD11_04600 ENOG4105C7W Xanthine dehydrogenase EYD11_04605 ENOG410873Y FAD binding domain in molybdopterin dehydrogenase EYD11_04610 ENOG4107UUR Chlorohydrolase aminohydrolase EYD11_04615 ENOG4105BZ8 glutamate synthase EYD11_04620 ENOG4105MFX 4-diphosphocytidyl-2c-methyl-d-erythritol synthase EYD11_04625 ENOG4105MJ6 selenium-dependent hydroxylase accessory protein YqeC EYD11_04630 ENOG4107P0T Selenium-dependent molybdenum hydroxylase system protein, YqeB family EYD11_04635 ENOG4105C5B carbamate kinase EYD11_04645 ENOG4107S4Y M20 DapE family protein YgeY EYD11_04650 ENOG4107RCH Diaminopropionate ammonia-lyase EYD11_04655 ENOG4105IW6 Carbamoyltransferase EYD11_04660 ENOG4108JUB Transcriptional regulator EYD11_04665 ENOG4108UTP (2Fe-2S)-binding domain protein EYD11_04670 ENOG4108HR6 Dehydrogenase EYD11_04675 ENOG4105C7W Xanthine dehydrogenase EYD11_04680 ENOG4108K5P (LipO)protein EYD11_04690 ENOG4108IYT Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) EYD11_04715 ENOG4105D70 Integrase catalytic subunit EYD11_04720 ENOG4105F5W AtP-binding protein EYD11_04735 ENOG4108SER Transposase EYD11_04750 ENOG41075IY surface presentation of antigens protein SpaP EYD11_04760 ENOG4108TN6 type iii secretion EYD11_04765 ENOG4108M6W surface presentation of antigens protein SpaS EYD11_04770 ENOG4108M6W surface presentation of antigens protein SpaS EYD11_04785 ENOG4108RC9 Type III secretion system protein EYD11_04790 ENOG4108RC9 Type III secretion system protein EYD11_04795 ENOG4105Y7Q type iii secretion EYD11_04800 ENOG4106BTR EYD11_04805 ENOG4108RBT type iii secretion EYD11_04835 ENOG4108YAB Invasion protein EYD11_04860 ENOG4105FV3 EYD11_04865 ENOG4108TC1 Transcriptional regulator EYD11_04870 ENOG4105ISV protein with bipartite regulator domain EYD11_04875 ENOG4108MHD transport protein EYD11_04880 ENOG4105CHU acetyl-coa acetyltransferase EYD11_04890 ENOG4105CHR reductase EYD11_04895 ENOG4107QNK )-transporter EYD11_04905 ENOG4105RQF LysR family Transcriptional regulator EYD11_04910 ENOG4105CU5 Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine (By similarity) EYD11_04915 ENOG41060NJ transcriptional regulator EYD11_04930 ENOG4105CPC Aldo Keto reductase EYD11_04935 ENOG4105SUV lipoprotein YgdR EYD11_04940 ENOG4105EE5 Membrane protein terC EYD11_04960 ENOG4108HRM phosphoenolpyruvate--protein phosphotransferase EYD11_04975 ENOG4105IPU prepilin peptidase dependent protein A EYD11_04980 ENOG4105JCS prepilin peptidase dependent protein EYD11_04985 ENOG4105SEN Protein of unknown function (DUF2509) EYD11_04990 ENOG4105RVB Prepilin peptidase dependent protein c EYD11_04995 ENOG4105DSY exodeoxyribonuclease V, gamma EYD11_05000 ENOG4107QXK peptidase EYD11_05005 ENOG4107QKA exodeoxyribonuclease V beta EYD11_05010 ENOG4107QYX exodeoxyribonuclease v alpha EYD11_05015 ENOG4107QZM n-acetylglutamate synthase EYD11_05020 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase EYD11_05040 ENOG4105CA3 membrane-bound lytic murein transglycosylase EYD11_05045 ENOG4105CUZ uba thif-type nad fad binding protein EYD11_05050 ENOG4105P9C Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity) EYD11_05055 ENOG4105C9B Cysteine desulfurase EYD11_05060 ENOG4105M5B (LipO)protein EYD11_05065 ENOG4105ETT transcriptional Regulator, LysR family EYD11_05070 ENOG4105M08 Membrane EYD11_05080 ENOG4107EDW L-fucose operon activator EYD11_05090 ENOG4105CMG Carbohydrate kinase EYD11_05100 ENOG4105EDR glucose galactose transporter EYD11_05105 ENOG4107W7X Aldolase EYD11_05110 ENOG4105C0A alcohol dehydrogenase EYD11_05120 ENOG4105EJQ L-serine dehydratase EYD11_05125 ENOG4105C44 Serine transporter EYD11_05130 ENOG4105EWT decarboxylase family EYD11_05145 ENOG4105WP7 tRNA pseudouridine synthase C EYD11_05150 ENOG4105DR9 pseudouridine synthase EYD11_05155 ENOG4105QDK Flavodoxin EYD11_05160 ENOG4105DJB Major Facilitator Superfamily EYD11_05165 ENOG4105EQX glucarate dehydratase EYD11_05170 ENOG4105EQX glucarate dehydratase EYD11_05175 ENOG4105BZU Histidine kinase EYD11_05180 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) EYD11_05185 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) EYD11_05190 ENOG4106A2Z transcriptional regulator antitoxin, MazE EYD11_05195 ENOG4105MZG transcriptional modulator of maze toxin, mazf EYD11_05200 ENOG4105DXN mazG family EYD11_05215 ENOG4105HA9 of methanol dehydrogenase type EYD11_05225 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) EYD11_05230 ENOG4108CWB sugar kinase ygcE EYD11_05235 ENOG4108ITV Inner membrane protein yqcE EYD11_05240 ENOG4105CHR reductase EYD11_05245 ENOG4107R3A FAD linked oxidase domain protein EYD11_05250 ENOG4105C54 Major Facilitator superfamily EYD11_05255 ENOG4106IKH Electron transfer flavoprotein EYD11_05260 ENOG4105YBM electron transfer flavoprotein subunit ygcQ EYD11_05265 ENOG4108ZIA glycerol-3-phosphate responsive antiterminator EYD11_05270 ENOG4105WQV ferredoxin-like protein EYD11_05275 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase EYD11_05280 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase EYD11_05305 ENOG4105DTT CRISPR-associated helicase, cas3 EYD11_05310 ENOG4105CYR Crispr-associated protein, cse1 family EYD11_05315 ENOG41061HK CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA) EYD11_05320 ENOG41060M0 Crispr-associated protein, cse4 family EYD11_05325 ENOG4108VWQ crispr-associated protein EYD11_05330 ENOG4108Y7V CRISPR-associated protein, Cse3 family EYD11_05335 ENOG4105TZK CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. May be involved in the integration of spacer DNA into the CRISPR cassette (By similarity) EYD11_05340 ENOG4105PWE CRISPR-associated protein cas2 EYD11_05345 ENOG4108MXK alkaline phosphatase isozyme conversion EYD11_05365 ENOG4105N0Z inner membrane protein ygbE EYD11_05400 ENOG4108K5P (LipO)protein EYD11_05405 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) EYD11_05410 ENOG4105C6Z Gluconate EYD11_05415 ENOG4105QG4 Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde) (By similarity) EYD11_05420 ENOG4105FB2 class II Aldolase EYD11_05425 ENOG4105G63 Type III effector Hrp-dependent EYD11_05430 ENOG4105ZXK Dehydrogenase EYD11_05435 ENOG4105MVE transcriptional regulator EYD11_05440 ENOG4105MEW serine threonine protein phosphatase EYD11_05450 ENOG4105VXR cytoplasmic protein EYD11_05455 ENOG4108JUA Transcriptional regulator EYD11_05460 ENOG4105C45 hydrogenase expression formation protein (HypE) EYD11_05465 ENOG4105CQS hydrogenase expression formation protein HypD EYD11_05470 ENOG41083WG hydrogenase assembly chaperone EYD11_05475 ENOG4107RSS Hydrogenase accessory protein HypB EYD11_05480 ENOG410816D Probably plays a role in a hydrogenase nickel cofactor insertion step (By similarity) EYD11_05490 ENOG4108VRC Formate hydrogenlyase regulatory protein hycA EYD11_05495 ENOG4108MFN small subunit of hydrogenase-3, iron-sulfur protein (part of formate hydrogenlyase (FHL) complex) EYD11_05500 ENOG4107R30 NADH dehydrogenase EYD11_05505 ENOG4107TDF Formate hydrogenlyase subunit 4 EYD11_05510 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) EYD11_05515 ENOG4108RG7 formate hydrogenlyase complex iron-sulfur subunit EYD11_05520 ENOG4105C47 NADH ubiquinone oxidoreductase 20 kda subunit EYD11_05525 ENOG4105I6X formate hydrogenlyase maturation EYD11_05530 ENOG4108MG9 hydrogenase 3 maturation protease EYD11_05535 ENOG4105CS2 ec 3.2.1.21 EYD11_05540 ENOG4105C5Y PTS System EYD11_05545 ENOG4105DDV Transcriptional regulator (LacI family EYD11_05550 ENOG4108RC0 Electron transport protein EYD11_05555 ENOG4105C8H hydrogenase maturation protein Hypf EYD11_05565 ENOG4108ESE uses NADH to detoxify nitric oxide (NO), protecting several 4Fe-4S NO-sensitive enzymes. Has at least 2 reductase partners, only one of which (NorW, flavorubredoxin reductase) has been identified. NO probably binds to the di-iron center EYD11_05575 ENOG4105C2X Arabinose 5-phosphate isomerase EYD11_05580 ENOG410804X Transcriptional regulator EYD11_05585 ENOG4105J92 DNA-binding transcriptional activator GutM EYD11_05590 ENOG4107QMF Sorbitol-6-phosphate dehydrogenase EYD11_05595 ENOG4105VI0 Pts system, glucitol sorbitol-specific EYD11_05600 ENOG4105DZY Pts system, glucitol sorbitol-specific EYD11_05605 ENOG410787A Pts system, glucitol sorbitol-specific EYD11_05610 ENOG4105CVE Lytic murein transglycosylase EYD11_05615 ENOG4107TH8 cina domain protein EYD11_05630 ENOG4105CIM Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity) EYD11_05635 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) EYD11_05665 ENOG4107VXZ Hydrolase EYD11_05670 ENOG4105W39 Membrane EYD11_05685 ENOG4105C0R drug resistance transporter emrb qaca subfamily EYD11_05690 ENOG4105CW7 secretion protein, HlyD family EYD11_05695 ENOG4105NTK Transcriptional repressor Mpra EYD11_05700 ENOG4105ZED uncharacterized protein ygaH EYD11_05705 ENOG4108UMN azlc family EYD11_05715 ENOG4105GIJ Glycine betaine EYD11_05720 ENOG4108HQS Glycine betaine EYD11_05725 ENOG4108IJ7 Glycine betaine EYD11_05735 ENOG4107R25 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) EYD11_05740 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) EYD11_05745 ENOG4105G3E Probably involved in ribonucleotide reductase function (By similarity) EYD11_05750 ENOG4105WAZ (Glutaredoxin-like protein) NrdH EYD11_05755 ENOG4108ZQZ Bacterial protein of unknown function (DUF883) EYD11_05760 ENOG4108WMJ Protein of unknown function (DUF2002) EYD11_05765 ENOG4108RNS Exports L-alanine (By similarity) EYD11_05770 ENOG4108X73 DNA- binding protein EYD11_05775 ENOG4108V62 Rhodanese domain protein EYD11_05780 ENOG41080HT Transcriptional regulator, arsr family EYD11_05785 ENOG4105VPI YqaE family transport protein EYD11_05790 ENOG4109066 lysm domain bon superfamily protein EYD11_05795 ENOG4108PVQ transcriptional regulator EYD11_05800 ENOG4105C85 amino acid EYD11_05805 ENOG4108JPW Aminotransferase EYD11_05810 ENOG4105C26 Dehydrogenase EYD11_05815 ENOG4105D5U fad dependent oxidoreductase EYD11_05830 ENOG4105E54 alpha-amylase EYD11_05855 ENOG4108MGN ATP-binding component of a transport system EYD11_05870 ENOG4108Z1B Cyclase dehydrase EYD11_05875 ENOG4105VDB UPF0125 protein EYD11_05880 ENOG4105YRI Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) EYD11_05885 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) EYD11_05905 ENOG4108JU6 CBS domain protein EYD11_05910 ENOG4106KVJ cytochrome C assembly protein EYD11_05915 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY EYD11_05940 ENOG41090EK ompa motb domain protein EYD11_05945 ENOG4108KHX Diguanylate cyclase EYD11_05950 ENOG4108WS1 EYD11_05955 ENOG4105QP9 Protein of unknown function (DUF2799) EYD11_05960 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) EYD11_05965 ENOG4105EHE chorismate mutase- prephenate dehydrogenase EYD11_05970 ENOG4105CQC Prephenate dehydratase EYD11_05980 ENOG4108WPH sigma 54 modulation protein ribosomal protein S30EA EYD11_05985 ENOG4106SNF Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane EYD11_05990 ENOG4105C34 Pseudouridine synthase EYD11_05995 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase EYD11_06000 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit EYD11_06025 ENOG4105CSH Transporter EYD11_06030 ENOG4105T42 (LipO)protein EYD11_06035 ENOG4105JIM Phosphatidylserine synthase EYD11_06040 ENOG4105CD5 CoA-binding domain protein EYD11_06045 ENOG4106IUH DTW domain containing protein EYD11_06050 ENOG4105K63 Thioredoxin EYD11_06055 ENOG4105EIB trna rrna methyltransferase EYD11_06075 ENOG41090KR LysR family transcriptional Regulator EYD11_06080 ENOG4105C1J atp-dependent rna helicase EYD11_06085 ENOG4107S47 Specifically methylates the adenine in position 37 of tRNA(1)(Val) (anticodon cmo5UAC) (By similarity) EYD11_06090 ENOG4108IYU L-aspartate oxidase EYD11_06100 ENOG4105EMN RNA polymerase sigma factor EYD11_06105 ENOG41069PW sigma-e factor negative regulatory protein EYD11_06110 ENOG4105VQK sigma E regulatory protein, MucB RseB EYD11_06115 ENOG4105WMJ Positive regulator of sigma E, RseC MucC EYD11_06125 ENOG4105C3F Signal peptidase i EYD11_06145 ENOG4105CSZ Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity) EYD11_06160 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding EYD11_06165 ENOG4106G6Q Transcriptional regulator EYD11_06170 ENOG4105HYY HAD superfamily (Subfamily IF) hydrolase, YfhB EYD11_06175 ENOG4108Z6B deaminase EYD11_06185 ENOG4107QIK phosphoribosylformylglycinamidine synthase EYD11_06190 ENOG4107WP9 Histidine kinase EYD11_06195 ENOG4108SKK alpha helix protein EYD11_06200 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family EYD11_06205 ENOG4108YZA Nitrogen regulatory protein pii EYD11_06210 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) EYD11_06220 ENOG4108NZE NAGC-like transcriptional regulator EYD11_06225 ENOG4107HQ7 repeat protein EYD11_06230 ENOG4105FCA ABC transporter periplasmic-binding protein YphF EYD11_06235 ENOG4108F37 ATP-binding component of a transport system EYD11_06240 ENOG4105CNN ABC, transporter EYD11_06245 ENOG4105CPQ Dehydrogenase EYD11_06250 ENOG4108ZKT aldose 1-epimerase EYD11_06255 ENOG4108SB3 DoxX Family EYD11_06280 ENOG4105FUY alpha subunit EYD11_06285 ENOG4108W5M transcriptional regulator EYD11_06290 ENOG4105D8G Major Facilitator superfamily EYD11_06295 ENOG4108MN2 Stationary phase inducible protein CsiE EYD11_06300 ENOG4107XM9 (LipO)protein EYD11_06325 ENOG4107XTC May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins EYD11_06345 ENOG4108ZIT Ferredoxin, 2FE-2S EYD11_06350 ENOG4105WVQ Fe-S assembly protein IscX EYD11_06360 ENOG4105YYA enhanced serine sensitivity protein SseB EYD11_06365 ENOG4105KHC sulfurtransferase EYD11_06370 ENOG4105DN3 alpha-2-macroglobulin domain protein EYD11_06375 ENOG4108JQB penicillin-binding protein 1C EYD11_06405 ENOG4105N21 Membrane EYD11_06420 ENOG4105VPD cellular component movement EYD11_06430 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) EYD11_06440 ENOG41066DY Membrane EYD11_06445 ENOG4108ZMA Outer membrane lipoprotein EYD11_06450 ENOG41062G3 Protein of unknown function (DUF2633) EYD11_06455 ENOG4105BZU Histidine kinase EYD11_06460 ENOG4105C9X ppx gppa phosphatase EYD11_06465 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) EYD11_06470 ENOG4108V3E phosphoribosylglycinamide formyltransferase EYD11_06485 ENOG4105C2W permease EYD11_06495 ENOG4105K89 arsenate reductase EYD11_06500 ENOG4105ERG peptidase m48, ste24p EYD11_06505 ENOG4105C02 permease EYD11_06510 ENOG4105TMB Formate nitrite transporter EYD11_06515 ENOG4108JUA Transcriptional regulator EYD11_06520 ENOG4105I6X formate hydrogenlyase maturation EYD11_06525 ENOG4105C47 NADH ubiquinone oxidoreductase 20 kda subunit EYD11_06535 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) EYD11_06540 ENOG4108JPZ Monovalent cation H antiporter subunit D EYD11_06545 ENOG4107WQX hydrogenase 4 membrane subunit EYD11_06550 ENOG4105D65 subunit l EYD11_06555 ENOG4107TDF Formate hydrogenlyase subunit 4 EYD11_06560 ENOG4108JPZ Monovalent cation H antiporter subunit D EYD11_06565 ENOG4108MFN small subunit of hydrogenase-3, iron-sulfur protein (part of formate hydrogenlyase (FHL) complex) EYD11_06570 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen EYD11_06575 ENOG4105RH4 Glycine cleavage system transcriptional repressor EYD11_06585 ENOG4107EG0 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) EYD11_06595 ENOG4105CGZ zinc metallopeptidase EYD11_06600 ENOG4105E0I Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP) (By similarity) EYD11_06605 ENOG4106KED esterase YpfH EYD11_06620 ENOG4105KUZ arsenate reductase EYD11_06630 ENOG4105BZS acriflavin resistance protein EYD11_06635 ENOG4105BZU Histidine kinase EYD11_06640 ENOG4105BZ8 glutamate synthase EYD11_06645 ENOG4107VIJ nudix hydrolase EYD11_06650 ENOG4108PVD exported protein EYD11_06655 ENOG4105CV1 Transketolase (EC 2.2.1.1) EYD11_06660 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) EYD11_06665 ENOG4105C6K Malic enzyme EYD11_06670 ENOG4108VJN May be involved in the formation of a specific microcompartment in the cell in which the metabolism of potentially toxic by-products takes place EYD11_06675 ENOG4106S4J ethanolamine utilization protein EutP EYD11_06680 ENOG4105NDK ethanolamine utilization protein EYD11_06685 ENOG4108PFF ethanolamine utilization cobalamin adenosyltransferase EYD11_06690 ENOG4107WUY phosphate acetyltransferase EYD11_06695 ENOG4105KNY Microcompartments protein EYD11_06700 ENOG4105WVM ethanolamine utilization protein EutN carboxysome structural protein Ccml EYD11_06705 ENOG4108EKI Dehydrogenase EYD11_06710 ENOG4107RWI ethanolamine utilization protein eutJ EYD11_06715 ENOG4105C0A alcohol dehydrogenase EYD11_06720 ENOG4105ENY Ethanolamine utilization protein eutH EYD11_06725 ENOG4105DYY Reactivating factor for ethanolamine ammonia lyase EYD11_06730 ENOG4105CPD ethanolamine ammonia-lyase EYD11_06740 ENOG4106D67 ethanolamine utilization protein EYD11_06745 ENOG4108X49 Ethanolamine utilization protein EutK EYD11_06750 ENOG4108K3Z AraC family transcriptional regulator EYD11_06760 ENOG4108KNB n-acetylmuramoyl-l-alanine amidase EYD11_06765 ENOG4108R6G acetyltransferase EYD11_06770 ENOG4105QZU Inner membrane protein YfeZ EYD11_06775 ENOG4105E7K (LipO)protein EYD11_06780 ENOG4105EZR dyp-type peroxidase family protein EYD11_06785 ENOG4107S1E Beta-lactamase EYD11_06790 ENOG4105C5Y PTS System EYD11_06805 ENOG4105I7Z Short-chain dehydrogenase reductase Sdr EYD11_06810 ENOG4108J2H Sulfate ABC transporter periplasmic sulfate-binding protein EYD11_06815 ENOG4108I5D sulfate abc transporter EYD11_06820 ENOG4105ECW sulfate abc transporter EYD11_06825 ENOG4108IJ6 ABC transporter EYD11_06830 ENOG4105C6T cysteine synthase EYD11_06835 ENOG4105WEC Molybdate metabolism regulator EYD11_06840 ENOG4105M0Y EYD11_06850 ENOG4105C5Y PTS System EYD11_06855 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) EYD11_06860 ENOG4105KZ7 phosphocarrier protein hpr EYD11_06865 ENOG4105C6T cysteine synthase EYD11_06880 ENOG4105C77 DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity) EYD11_06885 ENOG4105VRT cytoplasmic protein EYD11_06890 ENOG4105DHU Bile acid EYD11_06895 ENOG4108M0I Transcriptional regulator EYD11_06900 ENOG4108NFH Sugar hydrolase EYD11_06905 ENOG4107U5R The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity) EYD11_06910 ENOG4105EAA nucleoside EYD11_06920 ENOG4105CN8 Transcriptional regulator EYD11_06950 ENOG4105GXM Putative transcription regulator (DUF1323) EYD11_06955 ENOG4105HZG regulatoR EYD11_06970 ENOG4108KMM Diguanylate cyclase EYD11_06975 ENOG4108SER Transposase EYD11_06980 ENOG4105D9N nucleoside EYD11_06990 ENOG4109076 Conserved Protein EYD11_06995 ENOG4105VCT ion-transport protein YfeO EYD11_07005 ENOG4105R6B The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane (By similarity) EYD11_07010 ENOG410863U PTS System EYD11_07015 ENOG4105DC7 peptidase M24 EYD11_07020 ENOG4105CN9 Peptidase m42 family protein EYD11_07025 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) EYD11_07035 ENOG4105DY9 regulatoR EYD11_07040 ENOG4108HRK Histidine kinase EYD11_07045 ENOG4105CHM Aminotransferase EYD11_07055 ENOG4105D1S lipid A biosynthesis EYD11_07060 ENOG4105W9M Membrane EYD11_07070 ENOG4108V08 YfdX protein EYD11_07080 ENOG4105CFN oxalyl-CoA decarboxylase EYD11_07085 ENOG4108N2Y auxin Efflux EYD11_07090 ENOG4105C04 l-carnitine dehydratase bile acid-inducible protein F EYD11_07095 ENOG4105BZU Histidine kinase EYD11_07100 ENOG4108WQH regulatoR EYD11_07105 ENOG4105CW7 secretion protein, HlyD family EYD11_07110 ENOG4105C0R drug resistance transporter emrb qaca subfamily EYD11_07125 ENOG4106NDP Transcriptional regulator EYD11_07130 ENOG4108HKT sucrose-6-phosphate hydrolase EYD11_07135 ENOG4105D7K pfkb domain protein EYD11_07140 ENOG4105U0F oligosaccharide H symporter, major facilitator superfamily (MFS) EYD11_07150 ENOG4105S64 Formate nitrite transporter EYD11_07155 ENOG410903C (LipO)protein EYD11_07165 ENOG410836F Transposase EYD11_07170 ENOG4105CKF membrane protein involved in aromatic hydrocarbon degradation EYD11_07175 ENOG4105KZW UPF0381 protein EYD11_07190 ENOG4108BY2 phosphohistidine phosphatase EYD11_07200 ENOG4106PG1 outer membrane usher protein EYD11_07205 ENOG4108FZ9 Chaperone EYD11_07210 ENOG4105NEV Fimbrial EYD11_07215 ENOG4105UGQ Fimbrial EYD11_07220 ENOG4105US4 fimbrial-like protein yfcP EYD11_07235 ENOG4105C76 Specifically methylates the 50S ribosomal protein L3 on a specific glutamine residue (By similarity) EYD11_07250 ENOG4105EJ9 Membrane EYD11_07255 ENOG4108BPE -transporting atpase EYD11_07260 ENOG4105MH2 YfcL protein EYD11_07265 ENOG4105CWG Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity) EYD11_07270 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) EYD11_07275 ENOG4105F9N Major Facilitator Superfamily EYD11_07280 ENOG4106WZ1 flagella biosynthesis regulator EYD11_07285 ENOG4105CJ0 Catalyzes the oxidation of erythronate-4-phosphate to 3- hydroxy-2-oxo-4-phosphonooxybutanoate (By similarity) EYD11_07290 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) EYD11_07300 ENOG4105DQR SNARE associated Golgi EYD11_07310 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase EYD11_07315 ENOG4108S3P Sporulation domain protein EYD11_07320 ENOG4105E96 Colicin v production protein EYD11_07325 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase EYD11_07330 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase EYD11_07335 ENOG4105E89 ABC transporter EYD11_07340 ENOG4105E89 ABC transporter EYD11_07345 ENOG4105DSP amino acid AbC transporter EYD11_07350 ENOG4106YG3 ABC transporter EYD11_07355 ENOG4108JEH abc transporter atp-binding protein EYD11_07360 ENOG4105DNE Transposase EYD11_07365 ENOG4105ECP epimerase EYD11_07370 ENOG4105KKP D-erythro-7,8-dihydroneopterin triphosphate 2'-epimerase EYD11_07375 ENOG4105CYM Glutathione S-transferase EYD11_07380 ENOG4108SHQ Glutathione S-transferase EYD11_07385 ENOG4108RE9 Phosphodiesterase EYD11_07390 ENOG4105PTV Nudix Hydrolase EYD11_07395 ENOG4105CSX c4-dicarboxylate anaerobic carrier EYD11_07400 ENOG4105C6K Malic enzyme EYD11_07405 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) EYD11_07420 ENOG4105EVE HAD-superfamily hydrolase subfamily IA variant 3 EYD11_07425 ENOG4107QWE )-transporter EYD11_07435 ENOG4105CHM Aminotransferase EYD11_07440 ENOG4107NQ8 LysR family Transcriptional regulator EYD11_07455 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) EYD11_07460 ENOG4105GKE subunit e EYD11_07465 ENOG4107QIZ NADH dehydrogenase EYD11_07470 ENOG4107R0R NADH dehydrogenase subunit g EYD11_07480 ENOG4105P3U NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) EYD11_07485 ENOG4107UFS subunit j EYD11_07490 ENOG41080EA NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) EYD11_07495 ENOG4105D65 subunit l EYD11_07500 ENOG4105C8S subunit m EYD11_07510 ENOG4106HDC EYD11_07515 ENOG4106EES EYD11_07520 ENOG4105ZD8 EYD11_07525 ENOG4105GDX Domain of unknown function (DUF1877) EYD11_07530 ENOG4107VAM peptidase, m28 EYD11_07535 ENOG4105CP2 von willebrand factor, type a EYD11_07540 ENOG4105Z6G Protease that can act as an efficient and specific deubiquitinating enzyme in vitro. Does not possess desumoylating and deneddylating activities. The physiological substrate is EYD11_07550 ENOG4107YB6 acetyltransferase, (GNAT) family EYD11_07555 ENOG4105TNS Conserved Protein EYD11_07560 ENOG4105E4F Isochorismate synthase EYD11_07575 ENOG4108IPT Naphthoate synthase EYD11_07585 ENOG4105CEY Amp-dependent synthetase and ligase EYD11_07590 ENOG4106GZG polymyxin resistance protein B EYD11_07595 ENOG4105U65 Translocates 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol (alpha-L-Ara4N-phosphoundecaprenol) from the cytoplasmic to the periplasmic side of the inner membrane (By similarity) EYD11_07605 ENOG4105SA9 Catalyzes the transfer of the L-Ara4N moiety of the glycolipid undecaprenyl phosphate-alpha-L-Ara4N to lipid A. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity) EYD11_07610 ENOG4105F73 Catalyzes the deformylation of 4-deoxy-4-formamido-L- arabinose-phosphoundecaprenol to 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (By similarity) EYD11_07640 ENOG4108UII YfaZ family EYD11_07660 ENOG4105CSP Major Facilitator Superfamily EYD11_07675 ENOG4105DNE Transposase EYD11_07680 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) EYD11_07690 ENOG4107R5Y anaerobic glycerol-3-phosphate dehydrogenase, subunit A EYD11_07695 ENOG4105CXY transporter EYD11_07700 ENOG4106MZZ glycerophosphoryl diester phosphodiesterase EYD11_07710 ENOG4105FQR PH-inducible protein involved in stress response EYD11_07715 ENOG4105XPH Ferredoxin EYD11_07720 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) EYD11_07725 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) EYD11_07730 ENOG4107GHC outer membrane autotransporter EYD11_07740 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) EYD11_07745 ENOG4107FKF Uncharacterized protein conserved in bacteria (DUF2138) EYD11_07750 ENOG4108QJJ Protein of unknown function (DUF1175) EYD11_07755 ENOG4107S52 alpha-2-macroglobulin domain protein EYD11_07760 ENOG41081SK signal peptide protein EYD11_07765 ENOG4105EDV vault protein EYD11_07770 ENOG4105CHU acetyl-coa acetyltransferase EYD11_07775 ENOG4105CRW Short chain fatty acid transporter EYD11_07780 ENOG4107QNJ CoA-transferase subunit B EYD11_07785 ENOG4107QP7 CoA-transferase subunit A EYD11_07790 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family EYD11_07795 ENOG4105BZU Histidine kinase EYD11_07800 ENOG4105BZU Histidine kinase EYD11_07805 ENOG41068CG regulatoR EYD11_07810 ENOG4105E3G Phosphotransfer intermediate protein in two-component regulatory system with RcsBC EYD11_07815 ENOG4105FCK Membrane EYD11_07820 ENOG4105CJ2 (LipO)protein EYD11_07825 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) EYD11_07830 ENOG4105CF1 Alkylated DNA repair protein EYD11_07835 ENOG4105IBP Cyclic peptide transporter EYD11_07850 ENOG4108ZNS ferredoxin-type protein NapF EYD11_07855 ENOG41061Q0 Assembly protein for periplasmic nitrate reductase EYD11_07865 ENOG4108BGM Quinol dehydrogenase periplasmic component EYD11_07870 ENOG4105GXZ Ferredoxin-type protein NapH EYD11_07875 ENOG4108ZMS Electron transfer subunit of the periplasmic nitrate reductase complex NapAB (By similarity) EYD11_07880 ENOG4105CUW cytochrome C-TYPE protein EYD11_07885 ENOG4107EV4 once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system (By similarity) EYD11_07890 ENOG4105CA5 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes (By similarity) EYD11_07895 ENOG41060IM Heme exporter protein EYD11_07900 ENOG4105X3C heme exporter protein EYD11_07910 ENOG4105DA4 cytochrome c-type biogenesis protein EYD11_07915 ENOG4107QX9 Thiol disulfide interChange protein EYD11_07920 ENOG4105KWW Biogenesis protein EYD11_07925 ENOG4105WH1 Two component transcriptional regulator luxr family EYD11_07930 ENOG4108MGN ATP-binding component of a transport system EYD11_07940 ENOG4105E68 Sulfatase EYD11_07960 ENOG4105CFI type iii restriction protein res subunit EYD11_07965 ENOG4105I08 Pseudouridine synthase EYD11_07970 ENOG4105C2C drug resistance transporter, Bcr CflA EYD11_07975 ENOG4105HG6 EYD11_07980 ENOG4108JQ5 ABC transporter EYD11_07985 ENOG4108IYQ Binding-protein-dependent transport systems inner membrane component EYD11_07990 ENOG4108I5X binding-protein-dependent transport systems inner membrane Component EYD11_07995 ENOG4105E43 Extracellular solute-binding protein, family 5 EYD11_08000 ENOG4105CXC rtn protein EYD11_08005 ENOG4107TT5 NLP P60 protein EYD11_08010 ENOG41076MN Phosphoesterase, PA-phosphatase related EYD11_08015 ENOG4105CKI cobalamin synthesis protein EYD11_08020 ENOG4105DEI Mannitol dehydrogenase EYD11_08030 ENOG4105KRS Proteinase inhibitor EYD11_08035 ENOG4105S8Q sugar efflux transporter EYD11_08040 ENOG4105DTZ bifunctional PTS system fructose-specific transporter subunit IIA HPr protein EYD11_08045 ENOG4105DE4 1-phosphofructokinase EYD11_08050 ENOG4105DM4 PTS System EYD11_08055 ENOG4105DD7 kinase (PfkB family EYD11_08060 ENOG4105D53 Catalyzes the hydrolysis of pseudouridine 5'-phosphate (PsiMP) to ribose 5-phosphate and uracil (By similarity) EYD11_08065 ENOG4105D9N nucleoside EYD11_08070 ENOG4108Y4K DNA-binding transcriptional activator EYD11_08080 ENOG4105D9N nucleoside EYD11_08085 ENOG4105DD7 kinase (PfkB family EYD11_08095 ENOG4105HMI Membrane EYD11_08100 ENOG4105DUM transcriptional regulator, lysR family EYD11_08105 ENOG4108IQI permease EYD11_08130 ENOG4105DHF Membrane EYD11_08135 ENOG41060NJ transcriptional regulator EYD11_08140 ENOG4105EMA Periplasmic binding protein LacI transcriptional regulator EYD11_08145 ENOG4105C2J ABC transporter EYD11_08150 ENOG4108HWV )-transporter EYD11_08155 ENOG4107SJI Dehydrogenase EYD11_08160 ENOG4105BZ8 glutamate synthase EYD11_08165 ENOG4105Y9N Membrane EYD11_08170 ENOG4107GZ4 SanA protein EYD11_08180 ENOG41067MG lrgb family EYD11_08190 ENOG4105FBT Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity) EYD11_08200 ENOG4105ETP RND efflux system, outer membrane lipoprotein EYD11_08205 ENOG4105H9W Short-chain dehydrogenase reductase Sdr EYD11_08210 ENOG4105KHU inner membrane protein YohD EYD11_08215 ENOG41069YE inner membrane protein yohC EYD11_08220 ENOG41061WM D-Alanyl-D-Alanine EYD11_08225 ENOG4105CXG d-lactate dehydrogenase EYD11_08230 ENOG4107QK4 glycoside hydrolase, family 3 domain protein EYD11_08235 ENOG4107SI7 Substrate-binding region of abc-type glycine betaine transport system EYD11_08240 ENOG4107T5X Binding-protein-dependent transport systems, inner membrane component EYD11_08245 ENOG4108IJ8 ABC transporter EYD11_08250 ENOG4105WJV Binding-protein-dependent transport systems, inner membrane component EYD11_08260 ENOG4108XDN Transcriptional regulator EYD11_08265 ENOG4108HRK Histidine kinase EYD11_08270 ENOG4108NEV two component transcriptional regulator, LytTR family EYD11_08275 ENOG4108W15 Protein of unknown function (DUF1456) EYD11_08280 ENOG4108YCW (LipO)protein EYD11_08285 ENOG410903U zinc ion binding EYD11_08290 ENOG4105DEG Vwa containing coxe family protein EYD11_08310 ENOG4108KDT Molybdate metabolism regulator EYD11_08315 ENOG4108KDT Molybdate metabolism regulator EYD11_08320 ENOG4108KDT Molybdate metabolism regulator EYD11_08330 ENOG4105D1F ATP-binding protein EYD11_08335 ENOG41067AK Protein of unknown function (DUF2574) EYD11_08340 ENOG41063W2 Fimbrial protein EYD11_08345 ENOG4108MQF Chaperone EYD11_08350 ENOG4105CW0 outer membrane usher protein EYD11_08355 ENOG410662B Type-1 fimbrial protein EYD11_08360 ENOG4108Z1S Influences nickel and cobalt homeostasis. May act by modulating RcnA-mediated export of these ions to avoid excess efflux. Not involved in nickel import and does not bind nickel or cobalt ions directly EYD11_08365 ENOG41061MD high-affinity nickel-transporter EYD11_08375 ENOG4105C4U 4-methyl-5-beta-hydroxyethylthiazole kinase EYD11_08380 ENOG4105DWF phosphomethylpyrimidine kinase EYD11_08385 ENOG4108UQ1 hydrolase, family 25 EYD11_08390 ENOG4105FDP GntR family transcriptional regulator EYD11_08395 ENOG4108TFM Kinase, PfkB family EYD11_08400 ENOG4108KD5 ADP-ribosylation crystallin J1 EYD11_08405 ENOG4105EAA nucleoside EYD11_08410 ENOG4105EIE fructose-bisphosphate aldolase EYD11_08425 ENOG41082GB PTS system galactitol-specific transporter subunit IIA EYD11_08430 ENOG41090UW PTS System EYD11_08435 ENOG4105DT3 PTS system, galactitol-specific IIc component EYD11_08440 ENOG4107WTH Galactitol-1-phosphate dehydrogenase EYD11_08455 ENOG41076Z6 Uncharacterized protein yegR EYD11_08460 ENOG4105CFP Peptidase U32 EYD11_08465 ENOG4105KWI UPF0339 protein EYD11_08470 ENOG4105E3W Two component transcriptional regulator (Winged helix family EYD11_08475 ENOG4105EB3 Histidine kinase EYD11_08515 ENOG4108M24 von Willebrand factor, type A EYD11_08525 ENOG4106E1W protein with protein kinase and helix-hairpin-helix DNA-binding EYD11_08530 ENOG4105R8A Heat shock protein EYD11_08535 ENOG4105D03 DNA-3-methyladenine glycosylase II EYD11_08545 ENOG410836F Transposase EYD11_08555 ENOG4105DBI uridine monophosphokinase EYD11_08565 ENOG4108GAE asmA family EYD11_08570 ENOG4105EE5 Membrane protein terC EYD11_08580 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase EYD11_08590 ENOG4105F9F transposase EYD11_08605 ENOG4108MRJ EYD11_08610 ENOG4105DAY polysaccharide export protein EYD11_08630 ENOG4108ZPC Polysaccharide pyruvyl transferase EYD11_08665 ENOG4105DDI hemolysin-type calcium-binding region EYD11_08680 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) EYD11_08710 ENOG4105K8F Phosphoribosyl-amp cyclohydrolase EYD11_08725 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) EYD11_08730 ENOG4105ECC imidazole-glycerol-phosphate dehydratase EYD11_08755 ENOG4105VTW prevent-host-death family EYD11_08760 ENOG4105KRQ Addiction module toxin, Txe YoeB family EYD11_08765 ENOG4108535 NAD dependent epimerase/dehydratase family EYD11_08770 ENOG4105EQ1 Transcriptional regulator EYD11_08780 ENOG4105CUB amino acid EYD11_08785 ENOG4105CUC YeeE YedE family protein EYD11_08795 ENOG4105CJB Exodeoxyribonuclease I EYD11_08800 ENOG4105DZ1 carboxypeptidase EYD11_08810 ENOG4108S5C Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell (By similarity) EYD11_08815 ENOG4105DR8 Membrane EYD11_08835 ENOG4105EQR Transposase IS116 IS110 IS902 EYD11_08845 ENOG4108YXQ IS66 Orf2 family protein EYD11_08850 ENOG4105E5H Transposase EYD11_08870 ENOG4105MAW Antitoxin component of a toxin-antitoxin (TA) module. Labile antitoxin that counteracts the effect of the CbtA (YeeV) toxin. It does not bind to the cognate toxin but instead binds to MreB and FtsZ (the toxin targets), enhancing their polymerization by forming higher-order bundles EYD11_08875 ENOG4106WJE Protein of unknown function (DUF987) EYD11_08880 ENOG4108YGG dna repair protein EYD11_08885 ENOG4105MFG Antirestriction protein EYD11_08895 ENOG4106H6R UPF0380 protein EYD11_08910 ENOG4105F4K antigen 43 EYD11_08915 ENOG4105D70 Integrase catalytic subunit EYD11_08920 ENOG4105F5W AtP-binding protein EYD11_08975 ENOG4105KF5 hemolysin expression-modulating protein EYD11_09015 ENOG4105F9F transposase EYD11_09035 ENOG4108YZT Adenosylcobinamide kinase EYD11_09050 ENOG4108PXI ErfK YbiS YcfS YnhG EYD11_09060 ENOG4106P55 Transcriptional regulator EYD11_09065 ENOG4107R11 Transcriptional regulator EYD11_09090 ENOG4105CDY transcriptional regulatory protein EYD11_09095 ENOG4105FYV Amp nucleosidase EYD11_09100 ENOG4105CSH Transporter EYD11_09110 ENOG4105TNG K13735 adhesin invasin EYD11_09130 ENOG4108VKM cytochrome b561 EYD11_09135 ENOG4108MEK Metal-binding protein YodA EYD11_09150 ENOG4105VT2 5-hydroxyisourate hydrolase EYD11_09155 ENOG4105CK6 Two component transcriptional regulator (Winged helix family EYD11_09160 ENOG4107ZY3 Histidine kinase EYD11_09175 ENOG4105ZIT Porin Gram-negative type EYD11_09180 ENOG4105Y0K Inner membrane protein YedR EYD11_09185 ENOG4105EST Metal Dependent Phosphohydrolase EYD11_09190 ENOG4105DVF Cytosine-specific methyltransferase EYD11_09195 ENOG41090BB DNA mismatch endonuclease (vsr) EYD11_09200 ENOG4105FDR Membrane EYD11_09205 ENOG4105CKW Inner membrane protein yedI EYD11_09210 ENOG4105VNZ cytoplasmic protein EYD11_09225 ENOG4105YX3 cellular response to acidity EYD11_09240 ENOG4107TKS colanic acid capsular biosynthesis activation protein A EYD11_09245 ENOG4105D19 Role in flagellar biosynthesis (By similarity) EYD11_09250 ENOG4105VS8 Flagellar biosynthetic protein fliq EYD11_09255 ENOG4105CN7 Flagellar biosynthetic protein FliP EYD11_09260 ENOG4105K0P flagellar biosynthesis protein EYD11_09265 ENOG4105DD5 Flagellar motor switch protein EYD11_09270 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) EYD11_09275 ENOG4107ZI8 flagellar basal body-associated protein flil EYD11_09280 ENOG4105WF4 Flagellar hook-length control protein EYD11_09285 ENOG4105GSA Flagellar export protein flij EYD11_09295 ENOG41090PJ Flagellar assembly protein EYD11_09300 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) EYD11_09305 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) EYD11_09330 ENOG4108RAV Conserved protein EYD11_09335 ENOG4105KSU Redox protein EYD11_09340 ENOG41066VF YeeE YedE family protein EYD11_09345 ENOG4108W9D (LipO)protein EYD11_09350 ENOG4105E5K Alpha-amylase EYD11_09355 ENOG4105YXP it directly binds FlhC, thus inhibiting the binding of the FlhC FlhD complex to class 2 promoters, resulting in decreased expression of class 2 flagellar operons. As a chaperone, effects FliD transition to the membrane by preventing its premature polymerization, and by directing it to the export apparatus (By similarity) EYD11_09360 ENOG4105MQ3 flagellar protein FliS EYD11_09365 ENOG4105DTS flagellar hook-associated EYD11_09370 ENOG4105I03 Flagellin EYD11_09375 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) EYD11_09380 ENOG4108M9K flagella biosynthesis protein FliZ EYD11_09385 ENOG4105EAB amino acid AbC transporter EYD11_09395 ENOG4105E5Q amino acid AbC transporter EYD11_09400 ENOG4105CDA abc transporter atp-binding protein EYD11_09405 ENOG4105VJY transcriptional regulator EYD11_09410 ENOG4105XVG cytoplasmic protein EYD11_09425 ENOG4105WH1 Two component transcriptional regulator luxr family EYD11_09435 ENOG4105BZQ cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase EYD11_09455 ENOG4106RHG Yeca family EYD11_09460 ENOG4105E0U tyrosine-specific transport protein EYD11_09465 ENOG4105VVZ metal-binding protein EYD11_09470 ENOG41090A1 ferritin EYD11_09475 ENOG4105P23 (LipO)protein EYD11_09485 ENOG4105N4N Protein of unknown function (DUF2766) EYD11_09490 ENOG4108UEC Ferritin-like protein EYD11_09495 ENOG4105DMK Periplasmic binding protein LacI transcriptional regulator EYD11_09500 ENOG4105C2J ABC transporter EYD11_09505 ENOG4105CNN ABC, transporter EYD11_09510 ENOG4108K4C ec 3.1.3.12 EYD11_09520 ENOG4108VA4 Universal stress protein EYD11_09530 ENOG4106CIA Functions in complex with FlhD as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region EYD11_09535 ENOG4107RD7 Flagellar Motor Protein, MotA EYD11_09540 ENOG4105ER2 Ompa motb domain protein EYD11_09545 ENOG4105CBS Chea signal transduction histidine kinase EYD11_09550 ENOG4108V3W Chemotaxis protein, CheW EYD11_09555 ENOG4105C8Q Methyl-accepting chemotaxis EYD11_09560 ENOG4105C8Q Methyl-accepting chemotaxis EYD11_09565 ENOG4105BZU Histidine kinase EYD11_09570 ENOG4105CMP catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR (By similarity) EYD11_09575 ENOG4108VYJ response regulator receiver protein EYD11_09580 ENOG4108KCC Plays an important role in bacterial chemotaxis signal transduction pathway by accelerating the dephosphorylation of phosphorylated CheY (CheY-P) (By similarity) EYD11_09585 ENOG4105D00 flagellar biosynthetic protein flhB EYD11_09590 ENOG4105D7B Flagellar biosynthesis protein flha EYD11_09595 ENOG4105W13 flagellar protein EYD11_09610 ENOG4106ZCM YecM protein EYD11_09620 ENOG4105CUW cytochrome C-TYPE protein EYD11_09625 ENOG4107QY8 reductase EYD11_09640 ENOG4105WJG Glutathione EYD11_09645 ENOG41081XQ Conserved Protein EYD11_09650 ENOG4105D3W isochorismatase EYD11_09660 ENOG4108TIT dATP pyrophosphohydrolase EYD11_09665 ENOG4105CDY transcriptional regulatory protein EYD11_09675 ENOG4107S01 Repressor protein MetJ EYD11_09695 ENOG4105FAV ABC, transporter EYD11_09700 ENOG4105FDK ABC transporter EYD11_09705 ENOG4105NXV High-affinity zinc uptake system protein EYD11_09710 ENOG4105DR5 peptidase EYD11_09715 ENOG4105NWR lipid A biosynthesis (Kdo)2-(Lauroyl)-lipid IVA acyltransferase EYD11_09720 ENOG4105CA9 Pyruvate kinase EYD11_09725 ENOG4106KNT transcriptional regulator EYD11_09730 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase EYD11_09735 ENOG4105C01 Dihydroxy-acid dehydratase EYD11_09740 ENOG4108UHU Aldolase EYD11_09750 ENOG4105X2V dna damage-inducible protein EYD11_09755 ENOG4105RSZ secreted protein EYD11_09760 ENOG4108Q2J Inner membrane protein YebE EYD11_09765 ENOG4105CUG Oligopeptidase b EYD11_09770 ENOG4105UMD exodeoxyribonuclease X EYD11_09775 ENOG4108YGA nitrilase cyanide hydratase and apolipoprotein n-acyltransferase EYD11_09780 ENOG4105MPK DNA polymerase III subunit theta EYD11_09785 ENOG4105FXM Copper resistance protein EYD11_09790 ENOG4108PNC copper resistance EYD11_09795 ENOG4105NKT exported protein EYD11_09800 ENOG4108R1E Serine threonine protein phosphatase 1 EYD11_09805 ENOG4105UVW uncharacterized protein yebW EYD11_09810 ENOG4105WT8 Protein of unknown function (DUF1480) EYD11_09820 ENOG4105DY2 Paraquat-inducible protein b EYD11_09825 ENOG4105H2K paraquat-inducible protein a EYD11_09830 ENOG4108ZGC gaf domain protein EYD11_09840 ENOG4105CN1 protease EYD11_09850 ENOG4105C0R drug resistance transporter emrb qaca subfamily EYD11_09855 ENOG4105J4Q Transcriptional regulator EYD11_09860 ENOG4105TIK EYD11_09870 ENOG4105Q3Y exported protein EYD11_09875 ENOG410610J Protein of unknown function (DUF2627) EYD11_09880 ENOG4105VEQ Cold shock protein EYD11_09885 ENOG4105DHI Methyltransferase EYD11_09900 ENOG4105F3R pts system mannose fructose sorbose family iid EYD11_09905 ENOG4105ETZ PTS System EYD11_09910 ENOG4108EQA pts system EYD11_09915 ENOG4105EE5 Membrane protein terC EYD11_09920 ENOG4107XTP (EAL) domain protein EYD11_09925 ENOG4105EJQ L-serine dehydratase EYD11_09935 ENOG4105CRQ synthase (Component I) EYD11_09945 ENOG4105V2F Uncharacterized protein yoac EYD11_09950 ENOG4105M4H endoribonuclease L-psp EYD11_09955 ENOG4105DVT helicase EYD11_09960 ENOG41072GX Peptidase M22 Glycoprotease EYD11_09965 ENOG4105Y4Z Outer Membrane Lipoprotein EYD11_09970 ENOG4105CEY Amp-dependent synthetase and ligase EYD11_09975 ENOG4105ZIE Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity) EYD11_09980 ENOG4105E3J oxidoreductase EYD11_09985 ENOG4105DVW rieske (2Fe-2S) EYD11_09990 ENOG4105C94 Transporter EYD11_09995 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) EYD11_10000 ENOG4105EJC lysr family transcriptional regulator EYD11_10010 ENOG4108YS1 cytoplasmic protein EYD11_10015 ENOG4105YP6 Domain of unknown function (DUF1869) EYD11_10020 ENOG4105Y3U Transglycosylase-associated protein EYD11_10030 ENOG4106G4W EYD11_10035 ENOG410620I Diguanylate cyclase EYD11_10040 ENOG4105UCG Domain of unknown function (DUF333) EYD11_10045 ENOG4105K78 MarR family Transcriptional regulator EYD11_10050 ENOG4105DJ2 Major Facilitator Superfamily EYD11_10055 ENOG4105R1U AraC Family Transcriptional Regulator EYD11_10070 ENOG4108KXH Ybak prolyl-tRNA synthetase associated EYD11_10075 ENOG4108KHP Diguanylate cyclase EYD11_10080 ENOG4106KTS Inner membrane protein yeaI EYD11_10090 ENOG4105CYN Serine protein kinase EYD11_10095 ENOG4105GNX MltA-interacting MipA family protein EYD11_10100 ENOG4105CV8 reductase EYD11_10105 ENOG4105DSB aldose 1-epimerase EYD11_10110 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase EYD11_10120 ENOG4105VUT cytoplasmic protein EYD11_10125 ENOG4105CPQ Dehydrogenase EYD11_10130 ENOG4107TE1 transport protein EYD11_10135 ENOG4105CPQ Dehydrogenase EYD11_10140 ENOG4105D2N Aldolase EYD11_10145 ENOG4107UH8 sugar kinase EYD11_10150 ENOG4105CPC Aldo Keto reductase EYD11_10155 ENOG4105E98 transcriptional regulator DeoR family EYD11_10160 ENOG4108KUU Inner membrane metabolite transport protein ydjE EYD11_10165 ENOG4108RWI nicotinamidase EYD11_10170 ENOG4105HDK L-asparaginase EYD11_10175 ENOG4105D07 Signal peptide peptidase, SppA EYD11_10180 ENOG41069NU Nitroreductase EYD11_10190 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) EYD11_10195 ENOG41065FB inner membrane protein ynji EYD11_10200 ENOG4105D82 Glutamate dehydrogenase EYD11_10205 ENOG4105MTM Protein of unknown function (DUF1496) EYD11_10210 ENOG4105M6F mutator MutT protein EYD11_10215 ENOG4108T9J Cdp-alcohol phosphatidyltransferase EYD11_10220 ENOG4107RM6 sulfurtransferase EYD11_10225 ENOG4108VGW abc transporter atp-binding protein EYD11_10230 ENOG4105CXZ ABC transporter, permease EYD11_10235 ENOG4105VNH ABC transporter solute-binding protein EYD11_10240 ENOG4107ZN8 Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) EYD11_10245 ENOG4108N5C SNARE associated Golgi protein-related protein EYD11_10250 ENOG4108KCW iron-sulfur cluster binding EYD11_10255 ENOG4108RSN SNARE associated Golgi EYD11_10260 ENOG4105CGK Exodeoxyribonuclease III EYD11_10270 ENOG4105F4X arginine EYD11_10290 ENOG4108SPG Periplasmic Protein EYD11_10300 ENOG4105DKD Incises the DNA at the 3' side of a lesion during nucleotide excision repair. Incises the DNA farther away from the lesion than UvrC. Not able to incise the 5' site of a lesion. When a lesion remains because UvrC is not able to induce the 3' incision, Cho incises the DNA. Then UvrC makes the 5' incision. The combined action of Cho and UvrC broadens the substrate range of nucleotide excision repair (By similarity) EYD11_10310 ENOG4105KKI DNA-binding transcriptional activator OsmE EYD11_10320 ENOG4105VZJ PTS System EYD11_10325 ENOG4105CK1 PTS System EYD11_10330 ENOG4105VCP PTS System EYD11_10335 ENOG4105EZV Transcriptional regulator EYD11_10340 ENOG4105F8D glycoside hydrolase family 4 EYD11_10350 ENOG4105CH6 catalase EYD11_10365 ENOG4108ETY sodium dicarboxylate symporter EYD11_10370 ENOG4107K5X Membrane-bound metal-dependent hydrolase EYD11_10375 ENOG4107UW8 HAD-superfamily hydrolase subfamily IA variant 3 EYD11_10380 ENOG4107PN8 YfeABCD locus regulator EYD11_10385 ENOG4105FGM Fructosamine kinase EYD11_10390 ENOG4105P10 Uncharacterized protein ydiZ EYD11_10395 ENOG4105DE4 1-phosphofructokinase EYD11_10400 ENOG4108NE3 Salt-induced outer membrane protein EYD11_10425 ENOG41082NX 50s ribosomal protein l35 EYD11_10430 ENOG4108YZX Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity) EYD11_10445 ENOG4105C6A phenylalanyl-tRNA synthetase (beta subunit) EYD11_10460 ENOG4108V06 Glutathione peroxidase EYD11_10470 ENOG4108QBX (LipO)protein EYD11_10475 ENOG4108TC0 Diguanylate phosphodiesterase EYD11_10485 ENOG4106EDX Hemin uptake protein EYD11_10490 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) EYD11_10500 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) EYD11_10505 ENOG4105CEY Amp-dependent synthetase and ligase EYD11_10510 ENOG41090P5 ferredoxin-like protein EYD11_10515 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase EYD11_10520 ENOG4105C10 Electron transfer flavoprotein EYD11_10525 ENOG4105CV7 Electron transfer flavoprotein EYD11_10530 ENOG4105W4W Transcriptional regulator EYD11_10535 ENOG4105C1G acyl-Coa dehydrogenase EYD11_10540 ENOG4107R0K CoA transferase having broad substrate specificity for short-chain acyl-CoA thioesters with the activity decreasing when the length of the carboxylic acid chain exceeds four carbons (By similarity) EYD11_10555 ENOG4105EMV Major Facilitator EYD11_10560 ENOG4105EMV Major Facilitator EYD11_10565 ENOG4105SUA Ydil protein EYD11_10575 ENOG4105IPI Membrane EYD11_10580 ENOG4105CQB FAD linked oxidase domain protein EYD11_10585 ENOG4105KA0 thioesterase Superfamily protein EYD11_10590 ENOG410671Z uncharacterized protein ydiH EYD11_10595 ENOG4108Z4V iron-sulfur cluster assembly EYD11_10600 ENOG4105DIW FeS assembly protein SUFB EYD11_10605 ENOG4105C3K feS assembly ATPase SufC EYD11_10610 ENOG4105JRK feS assembly protein SufD EYD11_10625 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein EYD11_10630 ENOG4105KMX major outer membrane lipoprotein EYD11_10635 ENOG4105CA9 Pyruvate kinase EYD11_10640 ENOG4105RFR Protein of unknown function (DUF2767) EYD11_10645 ENOG4108PU5 4fe-4S ferredoxin, iron-sulfur binding domain protein EYD11_10650 ENOG4105WE2 aldehyde ferredoxin oxidoreductase EYD11_10655 ENOG4105JVW EYD11_10660 ENOG4108393 oxidoreductase Fe-S subunit EYD11_10665 ENOG4108NWD Cytochrome EYD11_10670 ENOG4108Y7C Conserved Protein EYD11_10675 ENOG4108KTU conserved protein with FAD NAD(P)-binding domain EYD11_10680 ENOG4105N0V mono-oxygenase ydhR EYD11_10705 ENOG4108R6K riboflavin synthase, subunit alpha EYD11_10710 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase EYD11_10715 ENOG4105CZQ inner membrane transport protein YdhC EYD11_10720 ENOG4105F52 Transcriptional regulator EYD11_10735 ENOG4105F27 Major Facilitator EYD11_10740 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) EYD11_10745 ENOG4105K4H Nlp p60 protein EYD11_10750 ENOG4105M2J Glutaredoxin EYD11_10755 ENOG4107QRT dEAD DEAH box helicase EYD11_10760 ENOG4105DH5 Responsible for the end-turnover of tRNA specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis (By similarity) EYD11_10765 ENOG4108UYE Lactoylglutathione lyase EYD11_10770 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase EYD11_10775 ENOG4108WUH Transcriptional regulator, TetR family EYD11_10780 ENOG4105XZD Fe-S protein EYD11_10785 ENOG4107RGM aldo keto reductase EYD11_10790 ENOG4108Z7T Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) EYD11_10795 ENOG4105DSW Fusaric acid resistance protein EYD11_10800 ENOG4105Y49 secretion protein, HlyD family EYD11_10815 ENOG4108XTF Outer Membrane Lipoprotein EYD11_10825 ENOG410642K Lysozyme inhibitor EYD11_10840 ENOG4107XGF functions in a salvage pathway. Uses pyridoxamine (By similarity) EYD11_10845 ENOG4108K3A Glutathione S-transferase EYD11_10850 ENOG4105DUX Transporter EYD11_10855 ENOG4105CSM endonuclease III EYD11_10865 ENOG4108UQQ Electron transport complex EYD11_10890 ENOG4105M9B inner membrane protein ydgK EYD11_10895 ENOG4105QZ5 OriC-binding nucleoid-associated protein EYD11_10900 ENOG4106C6R beta-lactam resistance protein EYD11_10905 ENOG4105D9R oxidoreductase EYD11_10915 ENOG4105C87 Aminotransferase class I and II EYD11_10920 ENOG4105CI1 PTS System EYD11_10925 ENOG4107P2S Transcriptional regulator EYD11_10930 ENOG4107ZQV short-chain dehydrogenase reductase EYD11_10935 ENOG4105XEA Tetr family transcriptional regulator EYD11_10940 ENOG4105CNT hydrolase family 2 EYD11_10945 ENOG4105CT4 transporter EYD11_10950 ENOG4108QNI outer membrane porin protein EYD11_10955 ENOG4106J39 exported protein EYD11_10960 ENOG4105EIP mannose-6-phosphate isomerase EYD11_10965 ENOG4107GFK fumarate EYD11_10970 ENOG4105C9Q fumarate hydratase class II EYD11_10980 ENOG4105JJR Histidine kinase EYD11_10985 ENOG4107EXC regulatoR EYD11_10990 ENOG4105RA2 Membrane EYD11_10995 ENOG410642E Short chain dehydrogenase EYD11_11000 ENOG4105D5Q Arginine ornithine antiporter EYD11_11005 ENOG4105C5D exported protein EYD11_11010 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) EYD11_11015 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) EYD11_11020 ENOG4105DSF transport protein EYD11_11040 ENOG4105CVW peptidase s1 and s6 chymotrypsin hap EYD11_11055 ENOG4105D94 Major Facilitator Superfamily EYD11_11060 ENOG4106NZI LysR family Transcriptional regulator EYD11_11065 ENOG4105DAG ROK family EYD11_11070 ENOG4105EWW Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) EYD11_11080 ENOG4108NEM leader-binding protein dmsD EYD11_11085 ENOG4107KGK dmso reductase anchor subunit EYD11_11090 ENOG4105QAX Iron-sulfur EYD11_11095 ENOG4105C3J Cysteine desulfurase EYD11_11100 ENOG4107QY8 reductase EYD11_11105 ENOG4105KBG Protein of unknown function (DUF1161) EYD11_11115 ENOG4108MK9 spermidine N(1)-acetyltransferase EYD11_11130 ENOG4105CXK mandelate racemase muconate lactonizing EYD11_11135 ENOG4105CPQ Dehydrogenase EYD11_11145 ENOG4105DEI Mannitol dehydrogenase EYD11_11150 ENOG41061EV selenium-binding protein YdfZ EYD11_11155 ENOG4107XBN GntR Family Transcriptional Regulator EYD11_11160 ENOG4105EMU Dehydrogenase EYD11_11165 ENOG4105DGW oligopeptidase A EYD11_11170 ENOG4108WTK competence damage-inducible protein EYD11_11175 ENOG4108YDI single-species biofilm formation on inanimate substrate EYD11_11180 ENOG4105FSR swimming returnes to normal when residues 206-207 are both mutated to Ala. Overexpression also leads to a reduction in flagellar abundance and a 20-fold increase in c-di- GMP levels in vivo. Required for aminoglycoside-mediated induction of biofilm formation, it also plays a lesser role in biofilm production in response to other classes of translation inhibitors. The c-di-GMP produced by this enzyme up-regulates poly-GlcNAc production as well as the biofilm synthesis protein PgaD, although c-di-GMP is probably not the main inducing principle. Cyclic-di- GMP is a second messenger which controls cell surface-associated traits in bacteria EYD11_11190 ENOG4105E5W Transporter EYD11_11195 ENOG4108594 Permease of the drug metabolite transporter EYD11_11200 ENOG4106DNR multiple antibiotic resistance protein EYD11_11205 ENOG4108XW0 May be a transcriptional activator of genes involved in the multiple antibiotic resistance (Mar) phenotype. It can also activate genes such as sodA, zwf and micF EYD11_11210 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes EYD11_11230 ENOG4105EGI Transcriptional regulator EYD11_11235 ENOG4105C26 Dehydrogenase EYD11_11240 ENOG4105CSV Glutaminase EYD11_11245 ENOG4105M0C cytoplasmic protein EYD11_11250 ENOG4105BZU Histidine kinase EYD11_11255 ENOG4107QZW Altronate oxidoreductase EYD11_11260 ENOG4105FFC UPF0187 protein EYD11_11270 ENOG4105K34 Involved in the degradation of phospho-AI-2, thereby terminating induction of the lsr operon and closing the AI-2 signaling cycle. Catalyzes the cleavage of phosphorylated 4,5- dihydroxy-2,3-pentanedione (P-DPD) to 2-phosphoglycolic acid (PG) and another three-carbon compound EYD11_11275 ENOG41061GT Aldolase EYD11_11280 ENOG4105D4B ABC, transporter EYD11_11285 ENOG4105F5R ABC transporter EYD11_11290 ENOG41071MT Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Probably responsible for the translocation of the substrate across the membrane EYD11_11295 ENOG4105C2J ABC transporter EYD11_11300 ENOG4105DKT Transcriptional regulator EYD11_11305 ENOG4108EMV Catalyzes the phosphorylation of autoinducer 2 (AI-2) to phospho-AI-2, which subsequently inactivates the transcriptional regulator LsrR and leads to the transcription of the lsr operon. Phosphorylates the ring-open form of 4,5-dihydroxy-2,3- pentanedione (DPD), which is the precursor to all AI-2 signaling molecules, at the C5 position (By similarity) EYD11_11315 ENOG41061P8 Persistence to inhibition of murein or DNA biosynthesis regulatory protein EYD11_11320 ENOG4105CAF HipA N-terminal domain protein EYD11_11335 ENOG4108WDE Fimbrial protein EYD11_11340 ENOG4106318 fimbrial-like protein YdeR EYD11_11345 ENOG4106PIH fimbrial-like protein ydeQ EYD11_11350 ENOG4107QKC Oxidoreductase alpha (molybdopterin) subunit EYD11_11360 ENOG4105Z68 AraC Family Transcriptional Regulator EYD11_11365 ENOG4105ENH Sulfatase EYD11_11370 ENOG4105C4X radical SAM domain protein EYD11_11380 ENOG4105CQ0 ABC transporter EYD11_11385 ENOG4105PE1 Receptor EYD11_11390 ENOG4107RAN Peptidase, M16 EYD11_11395 ENOG4105CVK Glutamate decarboxylase EYD11_11400 ENOG4105E5D amino acid EYD11_11405 ENOG4105F32 YngK protein EYD11_11410 ENOG4105BZU Histidine kinase EYD11_11415 ENOG4105BZU Histidine kinase EYD11_11420 ENOG4108UQS dipeptidase EYD11_11425 ENOG4105DEF Extracellular solute-binding protein, family 5 EYD11_11430 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component EYD11_11435 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component EYD11_11440 ENOG4105C3U ABC transporter EYD11_11445 ENOG4107H6U ABC transporter EYD11_11450 ENOG4108Z9K Osmotically inducible protein EYD11_11455 ENOG4105TPS biofilm-dependent modulation protein EYD11_11460 ENOG4107AV5 Although this protein associates with the 30S subunit of the ribosome it is not considered to be a bona fide ribosomal protein EYD11_11470 ENOG4105DQ4 alcohol dehydrogenase EYD11_11475 ENOG41084S7 Plasmid maintenance system antidote protein EYD11_11480 ENOG4108MG3 formate dehydrogenase EYD11_11485 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein EYD11_11495 ENOG4105RPH Inner membrane protein YddG EYD11_11515 ENOG4107QND Nitrite extrusion protein EYD11_11525 ENOG4108IUE nitrate reductase beta subunit EYD11_11530 ENOG4108NZN Respiratory nitrate reductase 2 delta chain EYD11_11535 ENOG4105D0D Nitrate reductase 2, gamma subunit EYD11_11540 ENOG4105JAB phenazine biosynthesis protein, phzf family EYD11_11545 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase EYD11_11550 ENOG4108MEJ flavin reductase domain protein EYD11_11560 ENOG410600T transposase EYD11_11580 ENOG4105CNA YD repeat protein EYD11_11585 ENOG4105CS6 Rhs element vgr protein EYD11_11595 ENOG4108N27 Glutathione S-transferase EYD11_11600 ENOG4105C85 amino acid EYD11_11605 ENOG4108NS2 receptor EYD11_11610 ENOG4105CHB tonB-dependent Receptor EYD11_11615 ENOG4108WYP Transcriptional regulator EYD11_11620 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein EYD11_11625 ENOG4108Z7F N-acetyltransferase EYD11_11630 ENOG4108T9Y Inner membrane protein ydcZ EYD11_11635 ENOG4105R71 cytoplasmic protein EYD11_11640 ENOG410654E Membrane EYD11_11655 ENOG4105NRK Binding-protein-dependent transport systems, inner membrane component EYD11_11660 ENOG4105D81 ABC transporter, permease EYD11_11665 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) EYD11_11670 ENOG4107TYH extracellular solute-binding protein family 1 EYD11_11675 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family EYD11_11680 ENOG4105PF0 Antitoxin component of a toxin-antitoxin (TA) module. Functions as an mRNA interferase antitoxin EYD11_11690 ENOG4105RR0 Protein of unknown function (DUF2554) EYD11_11695 ENOG4105CFP Peptidase U32 EYD11_11700 ENOG4108JCI Transcriptional regulator EYD11_11705 ENOG4105DKK Benzoate EYD11_11710 ENOG4105D7V transposase EYD11_11720 ENOG4108KKZ (LipO)protein EYD11_11725 ENOG41088CC tellurite resistance protein tehB EYD11_11730 ENOG4108NKP c4-dicarboxylate transporter malic acid transport protein EYD11_11735 ENOG4107WE3 acetyltransferase YdcK EYD11_11740 ENOG4108Z9I -acetyltransferase EYD11_11745 ENOG4105Z2P Protein of unknown function (DUF465) EYD11_11755 ENOG4105E32 cytoplasmic protein EYD11_11760 ENOG4105DDW LysR family Transcriptional regulator EYD11_11765 ENOG4105C8Q Methyl-accepting chemotaxis EYD11_11775 ENOG4107NK6 Hok/gef family EYD11_11780 ENOG4105UPP uncharacterized protein ydcA EYD11_11785 ENOG4105CPW cytochrome b561 EYD11_11795 ENOG4105C26 Dehydrogenase EYD11_11800 ENOG4107DB1 DUF218 domain EYD11_11805 ENOG4105CQ7 ATP-dependent helicase EYD11_11815 ENOG41077RS Phosphatase EYD11_11820 ENOG4105E8V Alpha Beta Hydrolase Fold protein EYD11_11825 ENOG4108HPI phosphatidate Cytidylyltransferase EYD11_11830 ENOG4108UMZ Cdp-alcohol phosphatidyltransferase EYD11_11840 ENOG4107S5I aldo keto reductase EYD11_11845 ENOG4107EF2 surface-exposed virulence protein EYD11_11865 ENOG4108Z0R Transferase EYD11_11870 ENOG4105V9J phenylacetic acid degradation operon negative regulatory protein EYD11_11875 ENOG4105DZS Phenylacetate-CoA ligase EYD11_11880 ENOG4105CHU acetyl-coa acetyltransferase EYD11_11885 ENOG4108ZJI phenylacetic acid degradation protein EYD11_11890 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase EYD11_11895 ENOG4108UKI Enoyl-CoA hydratase EYD11_11900 ENOG4105E39 Enoyl-CoA hydratase EYD11_11905 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) EYD11_11910 ENOG4108ZA2 phenylacetate-CoA oxygenase PaaJ subunit EYD11_11915 ENOG4105D9S phenylacetate-CoA oxygenase PaaI subunit EYD11_11920 ENOG4105N76 Phenylacetate-CoA oxygenase, subunit EYD11_11925 ENOG4105CRS phenylacetate-CoA oxygenase PaaG subunit EYD11_11930 ENOG4105DXM phenylacetic acid degradation protein EYD11_11935 ENOG4105F11 amine oxidase EYD11_11940 ENOG4105C26 Dehydrogenase EYD11_11945 ENOG4108WFR AraC Family Transcriptional Regulator EYD11_11950 ENOG4105WXT Conserved Protein EYD11_11955 ENOG410689M (LipO)protein EYD11_11960 ENOG4107H52 Dicarboxylate transport EYD11_11965 ENOG4105C5I Dehydrogenase EYD11_11970 ENOG41090X5 Heat shock protein hslJ EYD11_11980 ENOG4105D95 Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity) EYD11_11985 ENOG4105FCK Membrane EYD11_11990 ENOG4108RW8 Universal stress protein F EYD11_12000 ENOG4105C1J atp-dependent rna helicase EYD11_12165 ENOG4105KUS lysozyme EYD11_12345 ENOG4108UUM single-stranded DNA-binding protein EYD11_12390 ENOG4105CDU Replicative dna helicase EYD11_12410 ENOG4105NY2 NinB protein EYD11_12435 ENOG4108DG9 Smr protein MutS2 EYD11_12440 ENOG4106KR7 LysR family Transcriptional regulator EYD11_12445 ENOG4105CH2 amidohydrolase EYD11_12450 ENOG4107RT5 aminobenzoyl-glutamate utilization protein B EYD11_12455 ENOG4105CFC Transporter EYD11_12460 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) EYD11_12465 ENOG4105DS0 Transcriptional regulator, Crp Fnr family EYD11_12470 ENOG4105Q9Y Universal stress protein EYD11_12475 ENOG4105S5I Membrane EYD11_12480 ENOG4105D64 Mechanosensitive ion channel EYD11_12485 ENOG4107QSI ABC, transporter EYD11_12490 ENOG4105EQ2 LysR family Transcriptional regulator EYD11_12495 ENOG4105ENX hydrolase EYD11_12510 ENOG4105KXI murein peptide amidase A EYD11_12515 ENOG4107S8C mandelate racemase muconate lactonizing EYD11_12520 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) EYD11_12525 ENOG4108JU8 Transcriptional regulator EYD11_12535 ENOG4105CM6 amino acid regulated cytosolic protein EYD11_12540 ENOG4105FKQ transcriptional regulator EYD11_12545 ENOG4107EFV Outer membrane protein G EYD11_12550 ENOG4108IJ9 (ABC) transporter EYD11_12555 ENOG4107URF beta-phospho-glucomutase EYD11_12560 ENOG4105C71 hydrolase family 65, central catalytic EYD11_12565 ENOG4105CK5 oxidoreductase EYD11_12570 ENOG4107TYA transient receptor potential locus EYD11_12575 ENOG4107RRD Dehydrogenase EYD11_12580 ENOG4105DRW binding-protein-dependent transport systems inner membrane Component EYD11_12585 ENOG4105HS6 binding-protein-dependent transport systems inner membrane Component EYD11_12595 ENOG4107QW3 Sucrose phosphorylase EYD11_12600 ENOG4105K8Z Phage shock protein EYD11_12605 ENOG4105NNG Peripheral inner membrane phage-shock protein EYD11_12610 ENOG4105FM1 phage shock protein C EYD11_12615 ENOG4105YYT phage shock protein B EYD11_12620 ENOG41087YS Phage shock protein A EYD11_12625 ENOG4105E51 psp operon transcriptional activator EYD11_12630 ENOG4108JPW Aminotransferase EYD11_12635 ENOG4105CJP fad dependent oxidoreductase EYD11_12640 ENOG4105C26 Dehydrogenase EYD11_12645 ENOG4107VRI Transcriptional regulator EYD11_12650 ENOG4108Z86 Glutamine amidotransferase EYD11_12655 ENOG4105CFQ glutamine synthetase EYD11_12665 ENOG4105CUB amino acid EYD11_12670 ENOG4105N0E Protein of unknown function (DUF2543) EYD11_12675 ENOG4108HIY periplasmic EYD11_12680 ENOG4108I5W peptide transport system, permease protein EYD11_12685 ENOG4108EU3 peptide transport system, permease EYD11_12690 ENOG4108JQ3 Peptide ABC transporter ATP-binding protein EYD11_12695 ENOG4108JQ2 peptide transport system atp-binding protein EYD11_12700 ENOG4105WDY DNA (cytosine-5-)-methyltransferase EYD11_12705 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH EYD11_12710 ENOG4105Q4T oxidoreductase EYD11_12725 ENOG4105BZU Histidine kinase EYD11_12735 ENOG4105N2W Transcriptional regulator EYD11_12740 ENOG41061RM osmotically inducible lipoprotein EYD11_12745 ENOG4108ZJT translation initiation factor, Sui1 EYD11_12755 ENOG4105CFV Tetratricopeptide repeat protein EYD11_12760 ENOG4105Q4A inner membrane protein yciS EYD11_12765 ENOG4105EYK Phosphatidylglycerophosphatase B EYD11_12775 ENOG4107QM5 aconitate hydratase EYD11_12800 ENOG4107R11 Transcriptional regulator EYD11_12805 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) EYD11_12810 ENOG4105RKX Protein of unknown function (DUF2498) EYD11_12815 ENOG4105ERU peptidase EYD11_12820 ENOG4105UBK short-chain dehydrogenase reductase EYD11_12825 ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase EYD11_12830 ENOG4105FE9 pseudouridine synthase EYD11_12835 ENOG4105EG3 transmembrane signal peptide protein EYD11_12840 ENOG4107RTD sua5 ycio yrdc ywlc family protein EYD11_12845 ENOG4105DB7 PHP domain protein EYD11_12855 ENOG4105CRQ synthase (Component I) EYD11_12860 ENOG4108EFP Anthranilate synthase component II EYD11_12865 ENOG4105DK0 Indole-3-glycerol phosphate synthase EYD11_12885 ENOG4108Z9Z response to DNA damage stimulus EYD11_12890 ENOG4108N8X transition metal ion binding EYD11_12895 ENOG4105EIF outer membrane protein W EYD11_12915 ENOG4105NAU thioesterase Superfamily protein EYD11_12920 ENOG410822N TonB family EYD11_12925 ENOG4105K9H YciI-like protein EYD11_12930 ENOG4107SVH Potassium channel protein EYD11_12950 ENOG4108JQ7 (ABC) transporter EYD11_12955 ENOG4105C3U ABC transporter EYD11_12960 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component EYD11_12970 ENOG4108J59 Extracellular solute-binding protein, family 5 EYD11_12975 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein EYD11_12980 ENOG4108EKI Dehydrogenase EYD11_12990 ENOG4107104 thymidine kinase EYD11_12995 ENOG4108SAU DNA-binding protein H-ns EYD11_13000 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase EYD11_13005 ENOG4105I93 response regulator EYD11_13010 ENOG4105D78 K07001 NTE family protein EYD11_13020 ENOG4105CIY formyltetrahydrofolate deformylase EYD11_13055 ENOG41076YT nitrate reductase, gamma subunit EYD11_13060 ENOG4105R3A Nitrate reductase EYD11_13065 ENOG4108IUE nitrate reductase beta subunit EYD11_13070 ENOG4105CRU nitrate reductase, alpha subunit EYD11_13075 ENOG4105DQQ Major facilitator superfamily MFS_1 EYD11_13080 ENOG4105BZU Histidine kinase EYD11_13085 ENOG4105WH1 Two component transcriptional regulator luxr family EYD11_13090 ENOG4105ID0 Putative invasin EYD11_13095 ENOG41090EX DsrE family EYD11_13100 ENOG4108NH8 Cation transport protein EYD11_13105 ENOG4105WS7 Cation transport regulator EYD11_13110 ENOG4105EWV Sodium calcium exchanger membrane region EYD11_13140 ENOG41063JG Transcriptional regulator EYD11_13145 ENOG4108YY7 Invasion gene expression up-regulator SirB EYD11_13150 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) EYD11_13160 ENOG4105C7E Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA) (By similarity) EYD11_13170 ENOG4105CTR Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity) EYD11_13175 ENOG4105C5T Phosphoribosyl pyrophosphate synthase EYD11_13180 ENOG4105CHH sulfate transporter EYD11_13185 ENOG4105MGX transcription activated by CRP (cyclic AMP receptor protein), a global transcription factor involved in regulation of metabolism in enteric bacteria EYD11_13195 ENOG4105C3G gtp-binding protein EYD11_13200 ENOG4105I1J Autotransporter EYD11_13205 ENOG4108JU9 GAF modulated sigma54 specific transcriptional regulator Fis family EYD11_13210 ENOG4105CMT Dihydroxyacetone kinase EYD11_13215 ENOG4108UTZ Dihydroxyacetone kinase EYD11_13220 ENOG4105VDH Dihydroxyacetone kinase EYD11_13235 ENOG4105Y3U Transglycosylase-associated protein EYD11_13240 ENOG4108T7K Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Increasing levels of c-di-GMP lead to decreased motility (By similarity) EYD11_13250 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A EYD11_13260 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) EYD11_13270 ENOG4105ED1 spovr family EYD11_13285 ENOG410635M Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein (By similarity) EYD11_13290 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) EYD11_13295 ENOG4105KT5 UmuD protein EYD11_13300 ENOG4106PXS Toxin, which has some hemolytic activity towards mammalian cells. Acts by forming a pore-like structure upon contact with mammalian cells EYD11_13310 ENOG4105FBJ fumarylacetoacetate (faa) hydrolase EYD11_13320 ENOG41066UD Inhibits activity of g-type lysozyme, which confers increased lysozyme tolerance to the bacterium EYD11_13325 ENOG4105S66 prophage protein EYD11_13335 ENOG4107QMS site-determining protein EYD11_13380 ENOG4105BZU Histidine kinase EYD11_13385 ENOG410738I uncharacterized protein ymgC EYD11_13395 ENOG41077SS Probably a connector protein for RcsB C regulation of biofilm formation, providing additional signal input into the two- component signaling pathway. May serve to stimulate biofilm maturation, probably via the Rcs phosphorelay. Mild overexpression at 16 degrees Celsius increases the production of colanic acid, an exopolysaccharide and matrix component, and reduces adhesive curli fimbriae expression. Both of these effects require RcsB EYD11_13400 ENOG4105WKE Probably a connector protein for RcsB C regulation of biofilm formation, providing additional signal input into the two- component signaling pathway. Partially antagonizes the activities of YmgA and AriR, proteins that, via the Rcs phosphorelay, promote the synthesis of colanic acid, an exopolysaccharide and matrix component EYD11_13405 ENOG4105BZU Histidine kinase EYD11_13410 ENOG4108XDN Transcriptional regulator EYD11_13415 ENOG41064WM Uncharacterized protein YcgX EYD11_13430 ENOG4108HMX isocitrate dehydrogenase (NADP) EYD11_13435 ENOG4108R99 pseudouridine synthase EYD11_13455 ENOG4107QTF adenylosuccinate lyase EYD11_13460 ENOG4105XJC Two component transcriptional regulator (Winged helix family EYD11_13465 ENOG4105IFJ Histidine kinase EYD11_13470 ENOG4105EZE Cupin 4 family protein EYD11_13480 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) EYD11_13485 ENOG4105F38 ABC transporter, permease EYD11_13495 ENOG4108WF3 methyltransferase EYD11_13525 ENOG4105EKQ RNA-directed DNA polymerase EYD11_13650 ENOG4105QYK bacteriophage lambda Bor protein homolog EYD11_13670 ENOG4105QFS Lysis protein S homolog from lambdoid prophage EYD11_13700 ENOG4105HGD Antitermination protein EYD11_13705 ENOG4105KSK (crossover) junction endodeoxyribonuclease EYD11_13710 ENOG4108MXB Protein of unknown function (DUF968) EYD11_13720 ENOG4105WI6 cell killing protein encoded within cryptic prophage EYD11_13795 ENOG4106G8A Qin prophage EYD11_13800 ENOG41076J9 exonuclease VIII EYD11_13810 ENOG4108I1J Integrase EYD11_13815 ENOG4105D38 putrescine abc transporter EYD11_13820 ENOG4107RUE extracellular solute-binding protein family 1 EYD11_13835 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) EYD11_13845 ENOG4105D60 lipoprotein releasing system transmembrane protein EYD11_13850 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) EYD11_13855 ENOG4105D60 lipoprotein releasing system transmembrane protein EYD11_13860 ENOG4105IQC Inner membrane protein YcfT EYD11_13865 ENOG4108JA2 transcriptioN-repair coupling factor EYD11_13870 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein EYD11_13875 ENOG4105RC8 Reduces the permeability of the outer membrane to copper. Seems to be involved in the regulation of biofilm formation. May decrease biofilm formation by repressing cell-cell interaction and cell surface interaction EYD11_13880 ENOG4108IND Tetr family transcriptional regulator EYD11_13885 ENOG4107MBR 17 kDa surface antigen EYD11_13890 ENOG4105CEP NADH dehydrogenase EYD11_13910 ENOG4108WEF Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b) (By similarity) EYD11_13915 ENOG41090DQ Lipoprotein EYD11_13920 ENOG4105K59 histidine triad (HIT) protein EYD11_13925 ENOG4105CNM Receptor EYD11_13930 ENOG4105CI1 PTS System EYD11_13935 ENOG4105F8V Hydrolase, tatD family EYD11_13940 ENOG4107QRG dna polymerase iii EYD11_13950 ENOG4105HHA aminodeoxychorismate lyase EYD11_13955 ENOG4105YAZ 4-amino-4-deoxychorismate lyase EYD11_13960 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) EYD11_13965 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) EYD11_13970 ENOG4105CHR reductase EYD11_13975 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase EYD11_13995 ENOG4105FCQ metal-binding, possibly nucleic acid-binding protein EYD11_14000 ENOG4108UHJ MAF-like protein EYD11_14005 ENOG4105EI2 Pseudouridine synthase EYD11_14015 ENOG41071G1 Uncharacterized protein YceQ EYD11_14020 ENOG4107QQB Ribonuclease E EYD11_14025 ENOG4105DTJ flagellar hook-associated protein EYD11_14030 ENOG4105E1Q flagellar hook-associated protein EYD11_14035 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj EYD11_14050 ENOG4105CGA flagellar basal-body rod protein FlgG EYD11_14055 ENOG4108KPB Flagellar basal-body rod protein FlgF EYD11_14060 ENOG4105BZE flagellar hook protein, FlgE EYD11_14065 ENOG4105W00 Flagellar hook capping protein EYD11_14070 ENOG4108ZC9 flagellar basal-body rod protein flgc EYD11_14075 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) EYD11_14080 ENOG4105CKS Flagella basal body P-ring formation protein flgA EYD11_14085 ENOG4105M9M anti-sigma28 factor FlgM EYD11_14090 ENOG4105QVD Flagella synthesis protein FlgN EYD11_14095 ENOG4105CJR Integral membrane protein (MviN EYD11_14100 ENOG4105EP9 oxidoreductase EYD11_14110 ENOG4105D9U N-acetyltransferase EYD11_14120 ENOG4105E9S glutaredoxin 2 EYD11_14125 ENOG4105F3T (LipO)protein EYD11_14135 ENOG4105MEA DNA damage-inducible protein i EYD11_14140 ENOG4105PVA Biofilm formation regulatory protein BssS EYD11_14150 ENOG4106974 biofilm formation EYD11_14155 ENOG4105DS1 cytochrome b561 EYD11_14160 ENOG4108YYC ycei family EYD11_14170 ENOG4105D1S lipid A biosynthesis EYD11_14180 ENOG4108W47 Acidic protein msyB EYD11_14185 ENOG4105NAC (LipO)protein EYD11_14190 ENOG4105C3A Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs) (By similarity) EYD11_14205 ENOG4107RZC phospholipase d EYD11_14210 ENOG4108UVJ appr-1-p processing domain protein EYD11_14220 ENOG4105RK8 Plays a role in the extracellular assembly of CsgA into thin aggregative fimbriae (Tafi) fibers. Assembly may also require CsgE. Tafi are thought to be assembled via an extracellular nucleation-precipitation (ENP) pathway, and possibly also via an intracellular non-CsgC-dependent pathway (By similarity) EYD11_14225 ENOG4105G76 Curli are coiled surface structures that assemble preferentially at growth temperatures below 37 degrees Celsius. Curli can bind to fibronectin EYD11_14230 ENOG4108U0V Curli are coiled surface structures that assemble preferentially at growth temperatures below 37 degrees Celsius. Curli can bind to fibronectin. The minor subunit is the nucleation component of curlin monomers EYD11_14235 ENOG41086KC Transcriptional regulator EYD11_14240 ENOG4108XDW curli assembly protein CsgE EYD11_14245 ENOG4108WYR Curli production assembly transport component, CsgF EYD11_14250 ENOG4105P8Q Curli production assembly transport component CsgG EYD11_14255 ENOG4108UQ5 membrane protein YcdZ EYD11_14260 ENOG4107XHZ cytoplasmic chaperone TorD family protein EYD11_14285 ENOG4108T85 Membrane EYD11_14300 ENOG4105BZU Histidine kinase EYD11_14305 ENOG4108TUY outer membrane protein PgaA EYD11_14310 ENOG4107BJW polysaccharide deacetylase EYD11_14315 ENOG4105CND Glycosyl transferase, family 2 EYD11_14320 ENOG4106FQ9 Biofilm PGA synthesis protein PgaD EYD11_14325 ENOG4105D5M phosphate starvation-inducible protein EYD11_14330 ENOG4105DBE peroxidase EYD11_14335 ENOG410650H (LipO)protein EYD11_14340 ENOG4105EKT )-iron permease EYD11_14345 ENOG4105CK7 Sodium proline symporter EYD11_14355 ENOG4105C26 Dehydrogenase EYD11_14360 ENOG4108R86 Transcriptional regulator EYD11_14385 ENOG41074FZ May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity) EYD11_14400 ENOG4105C2W permease EYD11_14405 ENOG4105XF5 Escherichia coli IMT2125 genomic chromosome, IMT2125 EYD11_14415 ENOG4105XH3 EYD11_14420 ENOG4105D6F Phosphatase EYD11_14440 ENOG4108SBI Involved in the biogenesis of TorA. Acts on TorA before the insertion of the molybdenum cofactor and, as a result, probably favors a conformation of the apoenzyme that is competent for acquiring the cofactor (By similarity) EYD11_14445 ENOG4107QY8 reductase EYD11_14450 ENOG4105CUW cytochrome C-TYPE protein EYD11_14455 ENOG4106WF9 DNA-binding transcriptional regulator TorR EYD11_14460 ENOG4108SV3 Tmao reductase system periplasmic protein tort EYD11_14465 ENOG4105BZU Histidine kinase EYD11_14470 ENOG4105HEE Binding Domain protein EYD11_14475 ENOG4106H71 Overexpression increases levels of unsaturated fatty acids and suppresses both the temperature-sensitive fabA6 mutation and cold-sensitive secG null mutation EYD11_14490 ENOG4105VEQ Cold shock protein EYD11_14495 ENOG41060EU Cold shock-like protein EYD11_14505 ENOG4108Y9B (LipO)protein EYD11_14510 ENOG4108W78 Pfam:DUF1017 EYD11_14515 ENOG4105E3R (LipO)protein EYD11_14520 ENOG4105DAY polysaccharide export protein EYD11_14525 ENOG4107ZF2 Phosphatase EYD11_14530 ENOG4105D75 Capsular exopolysaccharide family EYD11_14535 ENOG4105D6F Phosphatase EYD11_14545 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii EYD11_14550 ENOG4105C4M (Ubiquinol oxidase) subunit I EYD11_14555 ENOG4105MVP hydrogenase-1 operon protein HyaF EYD11_14560 ENOG4108VXY Hydrogenase-1 operon protein HyaE EYD11_14565 ENOG4108USZ hydrogenase EYD11_14570 ENOG4105X7T Ni Fe-hydrogenase, b-type cytochrome subunit EYD11_14575 ENOG4105DPX Hydrogenase, large subunit EYD11_14580 ENOG4105E3S small subunit EYD11_14590 ENOG4108MN8 Membrane EYD11_14595 ENOG4108Z0T Part of a sulfur-relay system (By similarity) EYD11_14600 ENOG4105VSY K01512 acylphosphatase EC 3.6.1.7 EYD11_14615 ENOG4105K4P CoA-binding domain protein EYD11_14630 ENOG41088T4 Helicase IV EYD11_14635 ENOG410901E Membrane EYD11_14640 ENOG4105EM2 membrane EYD11_14645 ENOG4108RZ1 DNA transformation protein EYD11_14655 ENOG4105UYK outer membrane protein a EYD11_14665 ENOG4105DAN ATP-dependent protease EYD11_14675 ENOG4105WFT During stationary phase, converts 70S ribosomes to an inactive dimeric form (100S ribosomes) (By similarity) EYD11_14680 ENOG4108Q2G (LipO)protein EYD11_14685 ENOG4105DY2 Paraquat-inducible protein b EYD11_14690 ENOG4105F1S paraquat-inducible protein a EYD11_14695 ENOG4105C5H ABC transporter EYD11_14700 ENOG4105C4H Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity) EYD11_14705 ENOG4105QVC MOSC domain-containing protein EYD11_14710 ENOG4108T7E Contributes to the efficiency of the cell division process by stabilizing the polymeric form of the cell division protein FtsZ. Acts by promoting interactions between FtsZ protofilaments and suppressing the GTPase activity of FtsZ (By similarity) EYD11_14720 ENOG4106PH7 chaperone EYD11_14725 ENOG4105MX3 Fimbrial EYD11_14730 ENOG4105Q7J Fimbrial EYD11_14735 ENOG4108MDY Fimbrial EYD11_14740 ENOG4105CW0 outer membrane usher protein EYD11_14745 ENOG4106JJN Part of the elfADCG-ycbUVF fimbrial operon, which promotes adhesion of bacteria to different abiotic surfaces. Could be required for the biogenesis of the ElfA fimbriae EYD11_14750 ENOG41071VI Part of the elfADCG-ycbUVF fimbrial operon, which promotes adhesion of bacteria to different abiotic surfaces. ElfA is the major fimbrial subunit produced by this operon EYD11_14755 ENOG4108UZX fmn reductase EYD11_14760 ENOG4105GVF (ABC) transporter EYD11_14770 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component EYD11_14775 ENOG4105E2Y ABC, transporter EYD11_14780 ENOG4105CD8 aminopeptidase N EYD11_14795 ENOG4105FCK Membrane EYD11_14800 ENOG4105CGF Aromatic amino acid aminotransferase EYD11_14805 ENOG4105C5X domain protein EYD11_14810 ENOG4105EAQ (twin-arginine translocation) pathway signal EYD11_14815 ENOG4105DIT ErfK YbiS YcfS YnhG family protein EYD11_14825 ENOG4105DAH Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF (By similarity) EYD11_14835 ENOG4106371 Methyltransferase EYD11_14840 ENOG4107S90 membrAne EYD11_14845 ENOG4107VR7 transferase activity, transferring phosphorus-containing groups EYD11_14860 ENOG4105T0Z Conserved Protein EYD11_14865 ENOG4105CHD Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1- P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA) (By similarity) EYD11_14870 ENOG4105BZ1 (ABC) transporter EYD11_14875 ENOG4108EQH DNA internalization-related competence protein ComEC Rec2 EYD11_14885 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) EYD11_14895 ENOG4108K0D peptidase, M48 EYD11_14910 ENOG4107VMU Membrane EYD11_14915 ENOG4105DDY UPF0142 protein ycaO EYD11_14920 ENOG4105TMB Formate nitrite transporter EYD11_14925 ENOG4105C6N Formate acetyltransferase EYD11_14930 ENOG4105F1A Pyruvate formate-lyase EYD11_14935 ENOG4108X0B nad(p)h dehydrogenase (quinone) EYD11_14940 ENOG410642W LysR family Transcriptional regulator EYD11_14945 ENOG4105E5D amino acid EYD11_14955 ENOG4105CHJ isochorismatase hydrolase EYD11_14960 ENOG4107KGK dmso reductase anchor subunit EYD11_14965 ENOG4105QAX Iron-sulfur EYD11_14970 ENOG4107QY8 reductase EYD11_14980 ENOG4105D1H recombination factor protein RarA EYD11_14990 ENOG4105CNU cell division protein FtsK EYD11_14995 ENOG4105EW9 transcriptional regulator AsnC family EYD11_15000 ENOG4105C3M thioredoxin reductase EYD11_15005 ENOG4108JJ9 ABC, transporter EYD11_15010 ENOG4108JJ8 (ABC) transporter EYD11_15020 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) EYD11_15035 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit EYD11_15045 ENOG4105VEQ Cold shock protein EYD11_15050 ENOG4105D6C Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity) EYD11_15055 ENOG4105DJY efflux transporter, rnd family, mfp subunit EYD11_15060 ENOG4108MJ5 VirK protein EYD11_15065 ENOG4105CPB ATP-dependent endonuclease of the OLD family EYD11_15070 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) EYD11_15075 ENOG4105DWU Membrane EYD11_15085 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) EYD11_15090 ENOG4105C7K acetolactate synthase EYD11_15095 ENOG4105C5W Aldolase EYD11_15100 ENOG4105CGD Nad-dependent epimerase dehydratase EYD11_15105 ENOG4107VBM 3-beta hydroxysteroid dehydrogenase isomerase EYD11_15110 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase EYD11_15120 ENOG41064MM (LipO)protein EYD11_15125 ENOG4105E5Z arginine transporter ATP-binding subunit EYD11_15130 ENOG4106PMH Extracellular solute-binding protein family 3 EYD11_15135 ENOG4105GBT ABC transporter EYD11_15140 ENOG4105DMR ABC, transporter EYD11_15145 ENOG4106TNF Periplasmic binding protein EYD11_15155 ENOG4105RBQ inner membrane protein ybjO EYD11_15160 ENOG4105D38 putrescine abc transporter EYD11_15165 ENOG4105F38 ABC transporter, permease EYD11_15170 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) EYD11_15175 ENOG4107RUE extracellular solute-binding protein family 1 EYD11_15180 ENOG4108RMJ sensory transduction regulator EYD11_15190 ENOG4108DBC nitroreductase EYD11_15195 ENOG4105X20 member of the soxRS regulon which mediates in part the increased levels of superoxide in response to oxidative stress EYD11_15200 ENOG41090BQ Glutaredoxin EYD11_15205 ENOG4105GWF inner membrane protein YbjM EYD11_15215 ENOG4108RFG Tetr family transcriptional regulator EYD11_15220 ENOG4106UW1 Major Facilitator superfamily EYD11_15225 ENOG4108HCJ Hydrolase EYD11_15235 ENOG4107QF7 multi-drug EYD11_15240 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase EYD11_15245 ENOG4107FB0 transcriptional regulator DeoR family EYD11_15250 ENOG4105DZ1 carboxypeptidase EYD11_15255 ENOG4108TGY Glutathione S-transferase EYD11_15260 ENOG4105D8V Glucose sorbosone dehydrogenase EYD11_15265 ENOG4105UFT Represses biofilm formation in M9C glu and LB glu media but not in M9C and LB media. Seems to act as a global regulator of several genes involved in catabolite repression and stress response and regulation of the uptake and export of signaling pathways. Could be involved the regulation of indole as well as uptake and export of AI-2 through a cAMP-dependent pathway EYD11_15275 ENOG41064RH membrane protein YliF EYD11_15285 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component EYD11_15295 ENOG4105DEF Extracellular solute-binding protein, family 5 EYD11_15300 ENOG4108JQ6 ABC transporter EYD11_15305 ENOG4105D44 asparaginase EYD11_15310 ENOG4105CVM Molybdenum cofactor synthesis domain protein EYD11_15315 ENOG4105D06 uba thif-type nad fad binding protein EYD11_15320 ENOG4107T9Z Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) EYD11_15325 ENOG4105F1A Pyruvate formate-lyase EYD11_15330 ENOG4105C6N Formate acetyltransferase EYD11_15335 ENOG4108HCJ Hydrolase EYD11_15340 ENOG41072TH Protein of unknown function (DUF1479) EYD11_15345 ENOG4105C5H ABC transporter EYD11_15350 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein EYD11_15355 ENOG4105F4P )-transporter EYD11_15360 ENOG4105KST dependent repressor EYD11_15370 ENOG4108I6E Sulfatase EYD11_15375 ENOG4108T1M outer membrane protein x EYD11_15385 ENOG4107AQZ Membrane EYD11_15395 ENOG4107R0W ABC transporter EYD11_15400 ENOG4105E5Q amino acid AbC transporter EYD11_15405 ENOG4105CDA abc transporter atp-binding protein EYD11_15410 ENOG4105D8X mechanosensitive ion channel EYD11_15420 ENOG4105ZY9 UPF0379 protein ybiM EYD11_15425 ENOG4108IU3 tonb-dependent siderophore receptor EYD11_15435 ENOG4105KSC Transcriptional regulator, TraR DksA family EYD11_15440 ENOG4105VR4 UPF0379 protein ybiJ EYD11_15445 ENOG4105DG4 malate L-lactate dehydrogenase EYD11_15450 ENOG4108MTB glycosyl transferase family EYD11_15455 ENOG4105DVT helicase EYD11_15460 ENOG4108UV1 cellular component movement EYD11_15465 ENOG4105C1J atp-dependent rna helicase EYD11_15470 ENOG4107MVR Transcriptional regulator EYD11_15480 ENOG4105CJ1 ABC, transporter EYD11_15485 ENOG4107QWP ABC-2 type transporter EYD11_15490 ENOG4107QWP ABC-2 type transporter EYD11_15495 ENOG4105I9U inner membrane protein ybhQ EYD11_15500 ENOG4105X23 Endonuclease Exonuclease phosphatase EYD11_15505 ENOG4105DZQ phospholipase D Transphosphatidylase EYD11_15510 ENOG4107UXM Membrane EYD11_15515 ENOG410733J conserved inner membrane protein EYD11_15520 ENOG4105HFZ Membrane EYD11_15525 ENOG4108ZAF Molybdopterin EYD11_15530 ENOG4105M00 molybdopterin converting factor, subunit 1 EYD11_15540 ENOG4108RIR Molybdenum cofactor biosynthesis protein EYD11_15550 ENOG4105CHW UPF0052 protein EYD11_15560 ENOG4105E78 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) EYD11_15565 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) EYD11_15570 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) EYD11_15580 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) EYD11_15585 ENOG4108V1U phospholipid-binding protein EYD11_15590 ENOG4105NBR Pectinesterase EYD11_15595 ENOG4107QM5 aconitate hydratase EYD11_15600 ENOG4107QPK )-transporter EYD11_15605 ENOG4105C7F AcnD-accessory protein PrpF EYD11_15610 ENOG4105F04 LysR family Transcriptional regulator EYD11_15620 ENOG4108K4B hydrolase EYD11_15625 ENOG4105CGB Part of the ABC transporter complex ModABC involved in molybdenum import. Responsible for energy coupling to the transport system (By similarity) EYD11_15630 ENOG4105E0C molybdate abc transporter EYD11_15635 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein EYD11_15640 ENOG410680R Protein of unknown function (DUF2592) EYD11_15645 ENOG4105F4R Transcriptional regulator mode EYD11_15650 ENOG4105DKW ABC transporter EYD11_15655 ENOG4105CMR udp-glucose 4-epimerase EYD11_15660 ENOG4105F0Z galactose-1-phosphate uridylyltransferase EYD11_15670 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) EYD11_15680 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) EYD11_15685 ENOG4105JND homeobox protein EYD11_15690 ENOG4105PGM cation diffusion facilitator family transporter EYD11_15695 ENOG4106Z1T Nicotinamide Mononucleotide Transporter EYD11_15745 ENOG4105UFD tol-pal system protein YbgF EYD11_15750 ENOG4105KCK Peptidoglycan-associated lipoprotein EYD11_15760 ENOG4108Z82 Cell envelope integrity inner membrane protein TolA EYD11_15765 ENOG4105M8F Biopolymer transport protein exbD tolR EYD11_15770 ENOG4105E02 MotA TolQ exbB proton channel EYD11_15775 ENOG4107YD3 Thioesterase EYD11_15780 ENOG4105KJB cyd operon protein YbgE EYD11_15790 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii EYD11_15795 ENOG4105C4M (Ubiquinol oxidase) subunit I EYD11_15805 ENOG4105C8I hydrolase, family 38 EYD11_15810 ENOG4105DM4 PTS System EYD11_15815 ENOG4105FDP GntR family transcriptional regulator EYD11_15820 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha EYD11_15830 ENOG4105C7S Dehydrogenase EYD11_15835 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 EYD11_15840 ENOG4105E33 succinate dehydrogenase EYD11_15845 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) EYD11_15850 ENOG4105N1I succinate dehydrogenase, hydrophobic membrane anchor protein EYD11_15855 ENOG4108UTY succinate dehydrogenase, cytochrome b556 subunit EYD11_15865 ENOG4105BZN citrate synthase EYD11_15870 ENOG4106UBK fimbrial-like adhesin protein EYD11_15875 ENOG4106PG1 outer membrane usher protein EYD11_15880 ENOG4108TTM chaperone EYD11_15885 ENOG4108MY7 Fimbrial EYD11_15890 ENOG4108KK1 membrane protein AbrB duplication EYD11_15905 ENOG4107R7A Allophanate hydrolase subunit 2 EYD11_15910 ENOG4105P4J Allophanate hydrolase, subunit 1 EYD11_15915 ENOG4107QNR UPF0135 protein EYD11_15920 ENOG4105DUX Transporter EYD11_15925 ENOG4105CVP deoxyribo-dipyrimidine photolyase EYD11_15930 ENOG4107SEY Conserved Protein EYD11_15950 ENOG4106R09 EYD11_15960 ENOG41079JQ Membrane EYD11_15965 ENOG4105CNA YD repeat protein EYD11_15970 ENOG4105XIQ Protein of unknown function (DUF2517) EYD11_15995 ENOG4105C08 Histidine kinase EYD11_16000 ENOG4105EEX Two component transcriptional regulator (Winged helix family EYD11_16015 ENOG4105D5Q Arginine ornithine antiporter EYD11_16035 ENOG4107QIX Phosphoglucomutase (EC 5.4.2.2 EYD11_16040 ENOG4107CDU Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated (By similarity) EYD11_16045 ENOG4105EV9 Alpha Beta Hydrolase EYD11_16050 ENOG4105NNH LexA regulated protein EYD11_16055 ENOG4105MHQ Low-potential electron donor to a number of redox enzymes (By similarity) EYD11_16065 ENOG41090R7 Ferric uptake EYD11_16070 ENOG4105GX6 (LipO)protein EYD11_16085 ENOG4105CI1 PTS System EYD11_16095 ENOG4105CE4 GlcNAc 6-P deacetylase EYD11_16100 ENOG4105E2R ROK family EYD11_16105 ENOG4105D4U had-superfamily hydrolase, subfamily iia EYD11_16110 ENOG4105CAQ asparagine synthetase EYD11_16150 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family EYD11_16160 ENOG4105C9A Phoh family EYD11_16170 ENOG4108JU5 Magnesium and cobalt efflux protein EYD11_16175 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) EYD11_16180 ENOG4107RP9 extracellular solute-binding protein, family 3 EYD11_16185 ENOG4105EAD ABC transporter EYD11_16190 ENOG4105DRP amino acid AbC transporter EYD11_16195 ENOG4105CDA abc transporter atp-binding protein EYD11_16205 ENOG4105F7F Chaperone EYD11_16210 ENOG4105QFC Hsc56 co-chaperone of HscC EYD11_16215 ENOG41069CF Protein of unknown function (DUF1266) EYD11_16220 ENOG4107JFD Sel1 repeat EYD11_16225 ENOG4105QFC Hsc56 co-chaperone of HscC EYD11_16230 ENOG41069CF Protein of unknown function (DUF1266) EYD11_16235 ENOG4105EUU Sel1 domain protein repeat-containing protein EYD11_16240 ENOG4107PAI alpha helical protein EYD11_16255 ENOG4105DJF DNA polymerase III, delta' subunit EYD11_16265 ENOG4108TGR phosphatase EYD11_16270 ENOG4105KEM Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) EYD11_16280 ENOG4105CJN penicillin-binding protein EYD11_16285 ENOG4105CNI cell division protein FtsW EYD11_16290 ENOG4105K6T rare lipoprotein A EYD11_16295 ENOG4105DZ1 carboxypeptidase EYD11_16310 ENOG41064T2 transcriptional regulator, lysR family EYD11_16320 ENOG410607N Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatE shares overlapping functions with TatA (By similarity) EYD11_16335 ENOG4105VEQ Cold shock protein EYD11_16340 ENOG41079UR PagP is required both for biosynthesis of hepta-acylated lipid A species containing palmitate and for resistance to cationic antimicrobial peptides (CAMPs). It catalyzes the transfer of a palmitate chain (16 0) from the sn-1 position of a glycerophospholipid to the free hydroxyl group of the (R)-3- hydroxymyristate chain at position 2 of lipid A (endotoxin) (By similarity) EYD11_16345 ENOG4105CEE C4-dicarboxylate transporter EYD11_16350 ENOG4106YYS transcriptional regulatory protein EYD11_16355 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism EYD11_16360 ENOG4105DUA (citrate (pro-3S)-lyase ligase EYD11_16370 ENOG4105CI0 Citrate lyase EYD11_16375 ENOG4105CHY citrate lyase, alpha EYD11_16390 ENOG4107QPK )-transporter EYD11_16395 ENOG4105KTS ribonuclease EYD11_16400 ENOG4105NXH GreA GreB family elongation factor EYD11_16405 ENOG4105E2A Dehydrogenase EYD11_16410 ENOG4108U51 Universal stress protein EYD11_16415 ENOG4108JU3 Alkyl hydroperoxide reductase EYD11_16420 ENOG4105D3R alkyl hydroperoxide reductase EYD11_16425 ENOG4108KHN disulfide isomerase, thiol-disulfide oxidase EYD11_16430 ENOG4105DQS Transcriptional regulator EYD11_16435 ENOG4105BZV Phosphoadenosine phosphosulfate reductase EYD11_16440 ENOG4105GTN ParB Domain Protein Nuclease EYD11_16445 ENOG4105CHM Aminotransferase EYD11_16450 ENOG4107SCQ Iron-containing alcohol dehydrogenase EYD11_16455 ENOG4105VCD cytoplasmic protein EYD11_16460 ENOG4105D22 carbon starvation protein EYD11_16465 ENOG4108TZA Required for optimal enterobactin synthesis. Acts as a proofreading enzyme that prevents EntB misacylation by hydrolyzing the thioester bound existing between EntB and wrongly charged molecules (By similarity) EYD11_16470 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase EYD11_16475 ENOG4105WQI isochorismatase EYD11_16480 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase EYD11_16485 ENOG4105E4F Isochorismate synthase EYD11_16490 ENOG4105PEC Iron-enterobactin transporter periplasmic binding protein EYD11_16500 ENOG4105DQ5 transport system permease protein EYD11_16505 ENOG4105TVJ transport system, permease EYD11_16510 ENOG4105E0A ABC, transporter EYD11_16515 ENOG4108QY5 Ferric enterobactin transport protein EYD11_16520 ENOG4105C0W non-ribosomal peptide synthetase EYD11_16525 ENOG41085A6 mbth domain-containing protein EYD11_16530 ENOG4105E93 esterase EYD11_16535 ENOG4107RNH Outer membrane receptor FepA EYD11_16540 ENOG4108TSE Transferase EYD11_16545 ENOG4108SER Transposase EYD11_16550 ENOG4105WI6 cell killing protein encoded within cryptic prophage EYD11_16590 ENOG4105HVQ Regulatory factor of maltose metabolism EYD11_16605 ENOG4107T8Q Glycosyl transferase (Group 1 EYD11_16610 ENOG4105PFA Catalyzes the conversion of 5-hydroxyuridine (ho5U) to 5-methoxyuridine (mo5U) at position 34 in tRNA (By similarity) EYD11_16615 ENOG4105CGN Glycosyl transferase (Group 1 EYD11_16620 ENOG4105CPK Glycosyl transferase (Group 1 EYD11_16640 ENOG4105CMR udp-glucose 4-epimerase EYD11_16645 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase EYD11_16665 ENOG4108RCM Nitroreductase EYD11_16670 ENOG4105CUY Mechanosensitive ion channel EYD11_16675 ENOG4105C85 amino acid EYD11_16680 ENOG4108IJF Heavy metal efflux pump, CzcA EYD11_16685 ENOG4105EP1 Efflux transporter rnd family, mfp subunit EYD11_16690 ENOG410624V efflux system protein EYD11_16695 ENOG4105ENJ RND efflux system, outer membrane lipoprotein EYD11_16700 ENOG4105CK6 Two component transcriptional regulator (Winged helix family EYD11_16705 ENOG4105GR3 Histidine kinase EYD11_16710 ENOG410802X bacteriophage n4 adsorption protein b EYD11_16715 ENOG41090FC Bacteriophage N4 receptor, outer membrane subunit EYD11_16720 ENOG4105QUW EYD11_16735 ENOG4108Q9V regulatoR EYD11_16740 ENOG4108ZI2 Fimbrial protein EYD11_16745 ENOG4108M66 Involved in regulation of length and mediation of adhesion of SfmA fimbriae (but not necessary for the production of fimbriae). Seems to be mannose binding adhesin (By similarity) EYD11_16750 ENOG4105CW0 outer membrane usher protein EYD11_16755 ENOG4108AF8 Chaperone EYD11_16760 ENOG4108WDE Fimbrial protein EYD11_16770 ENOG4105WQ3 Rna-binding protein EYD11_16775 ENOG4105S2T inner membrane protein YbcI EYD11_16785 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) EYD11_16795 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) EYD11_16800 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit EYD11_16805 ENOG4105C5B carbamate kinase EYD11_16810 ENOG4105G5A Protein of unknown function (DUF2877) EYD11_16815 ENOG4107REC cytoplasmic protein EYD11_16820 ENOG4107R1Q Membrane protein FdrA EYD11_16825 ENOG4105DG4 malate L-lactate dehydrogenase EYD11_16830 ENOG4105CE7 Amidase, hydantoinase carbamoylase family EYD11_16835 ENOG4105S0E allantoin catabolism protein EYD11_16840 ENOG4105BZW Glycerate kinase EYD11_16845 ENOG4105DTE Xanthine uracil vitamin C permease EYD11_16855 ENOG4105EW8 cytosine purines, uracil, thiamine, allantoin permease EYD11_16860 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase EYD11_16870 ENOG41060W2 glyoxylate carboligase EYD11_16875 ENOG4108N16 Negative regulator of allantoin and glyoxylate utilization operons. Binds to the gcl promoter and to the allS- allA intergenic region EYD11_16880 ENOG4108Z2U ureidoglycolate hydrolase EYD11_16885 ENOG4107653 Transcriptional regulator EYD11_16915 ENOG4105CNA YD repeat protein EYD11_16920 ENOG4105CV6 ABC transporter, permease EYD11_16925 ENOG4108I0Y (ABC) transporter EYD11_16930 ENOG4108UJV acyl-CoA thioesterase i EYD11_16935 ENOG4105E1F short-chain dehydrogenase reductase EYD11_16940 ENOG4107QR8 Thioredoxin EYD11_16945 ENOG4105C4B ABC transporter, permease EYD11_16950 ENOG41083J0 (ABC) transporter EYD11_16955 ENOG4107QX8 SPFH domain, Band 7 family protein EYD11_16960 ENOG4105G5H Membrane EYD11_16965 ENOG4108Z6Z Transcriptional regulator EYD11_16970 ENOG4107RY6 amino acid EYD11_16975 ENOG4105CSV Glutaminase EYD11_16980 ENOG4105C59 p-type ATPase EYD11_16985 ENOG41081XE plasmid maintenance system antidote protein, xre family EYD11_16995 ENOG4105MBR gumn family EYD11_17000 ENOG4108Z66 YbaK ebsC protein EYD11_17005 ENOG4105CGH 5'-nucleotidase EYD11_17010 ENOG4105EU0 Major facilitator Superfamily EYD11_17015 ENOG4105CKD glutathione-regulated potassium-efflux system protein EYD11_17020 ENOG4107RE1 Inosine-guanosine kinase EYD11_17040 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) EYD11_17055 ENOG4107QMP dna polymerase iii subunits gamma and tau EYD11_17065 ENOG4105WD1 Membrane EYD11_17070 ENOG4108URS primosomal replication protein n'' EYD11_17075 ENOG4106428 Protein of unknown function (DUF2496) EYD11_17080 ENOG4105EGS Mechanosensitive ion channel EYD11_17090 ENOG4105C1P efflux transporter, rnd family, mfp subunit EYD11_17095 ENOG4105BZS acriflavin resistance protein EYD11_17100 ENOG4108UKR Biofilm formation regulator YbaJ EYD11_17105 ENOG4105KF5 hemolysin expression-modulating protein EYD11_17110 ENOG4108UW5 maltose o-acetyltransferase EYD11_17115 ENOG4105GSJ Inner membrane protein ylaC EYD11_17120 ENOG41066DG (EAL) domain protein EYD11_17125 ENOG4105KCV RNA signal recognition particle 4.5S RNA EYD11_17135 ENOG41080UX Methyltransferase EYD11_17140 ENOG4108MNP Glycoprotein polysaccharide metabolism EYD11_17145 ENOG4105C29 acyl-CoA thioesterase EYD11_17150 ENOG4105BZU Histidine kinase EYD11_17155 ENOG4108YZA Nitrogen regulatory protein pii EYD11_17160 ENOG4105BZ1 (ABC) transporter EYD11_17165 ENOG4105BZ1 (ABC) transporter EYD11_17170 ENOG4108XM1 transcriptional regulator AsnC family EYD11_17180 ENOG4108NFA extracellular solute-binding protein EYD11_17190 ENOG4108TGP Thioesterase superfamily protein EYD11_17195 ENOG41083P1 competence protein ComEA helix-hairpin-helix repeat protein EYD11_17200 ENOG4105EIN peptidylprolyl cis-trans isomerase EYD11_17205 ENOG4105K70 DNA-binding protein EYD11_17210 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) EYD11_17230 ENOG4105M85 Bola protein EYD11_17235 ENOG4105IEY (LipO)protein EYD11_17240 ENOG4105EYM Major Facilitator superfamily EYD11_17245 ENOG4105E2S oxidase) subunit II EYD11_17250 ENOG4105BZ9 Cytochrome C oxidase, subunit I EYD11_17255 ENOG4105CCU oxidase (Subunit III) EYD11_17260 ENOG41090KH cytochrome o ubiquinol oxidase (subunit iv) EYD11_17270 ENOG4107RDB Major Facilitator EYD11_17280 ENOG4108JZF Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) EYD11_17285 ENOG4107S0N DJ-1 family EYD11_17300 ENOG4105CTB Polyprenyl synthetase EYD11_17310 ENOG4105CPC Aldo Keto reductase EYD11_17315 ENOG4108ZAI phosphatidylglycerophosphatase a EYD11_17320 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) EYD11_17330 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) EYD11_17335 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) EYD11_17345 ENOG4108KIC (LipO)protein EYD11_17350 ENOG4105DRB nucleoside-specific channel-forming protein EYD11_17355 ENOG4105N1F Hnh endonuclease EYD11_17360 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) EYD11_17365 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) EYD11_17370 ENOG4105VIE preprotein translocase, subunit YajC EYD11_17390 ENOG4107R28 alpha amylase, catalytic region EYD11_17395 ENOG4105C85 amino acid EYD11_17400 ENOG4105CWM branched-chain amino acid transport system II carrier protein EYD11_17405 ENOG4105BZU Histidine kinase EYD11_17410 ENOG4105CK6 Two component transcriptional regulator (Winged helix family EYD11_17415 ENOG4107RH8 nuclease SbcCD subunit D EYD11_17420 ENOG4105EYH Exonuclease EYD11_17425 ENOG4105F27 Major Facilitator EYD11_17430 ENOG4105DKQ ROK family EYD11_17455 ENOG4105HBA AroM protein EYD11_17460 ENOG4105SS3 EYD11_17475 ENOG4105II7 pyrroline-5-carboxylate reductase EYD11_17480 ENOG4105BZU Histidine kinase EYD11_17485 ENOG4105VIF phosphate starvation-inducible protein EYD11_17490 ENOG4105G6Z alkaline phosphatase EYD11_17500 ENOG4105CPF Cell wall formation (By similarity) EYD11_17505 ENOG4105UNH Membrane EYD11_17510 ENOG4105FR5 inner membrane protein YaiY EYD11_17515 ENOG4107QS8 (LipO)protein EYD11_17520 ENOG4108DQG in Escherichia coli SbmA is involved in uptake of microcin J25 EYD11_17525 ENOG4107R6D beta-lactam binding protein AmpH EYD11_17530 ENOG4108PNB DNA-binding transcriptional regulator EYD11_17540 ENOG4105D52 delta-aminolevulinic acid dehydratase EYD11_17545 ENOG4105E2B Taurine dioxygenase EYD11_17550 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component EYD11_17555 ENOG4108IY8 ABC, transporter EYD11_17560 ENOG4106FTQ Taurine ABC transporter, periplasmic EYD11_17570 ENOG4107W19 lmbE family EYD11_17575 ENOG4108PBI Polysaccharide metabolism EYD11_17585 ENOG4105SRB Uncharacterized protein yaiO EYD11_17590 ENOG410836F Transposase EYD11_17605 ENOG4105C4W S-formylglutathione hydrolase EYD11_17610 ENOG4105IUQ nucleoprotein polynucleotide-associated enzyme EYD11_17615 ENOG4108SC4 )-transporter EYD11_17630 ENOG4105IKQ hydratase EYD11_17635 ENOG4106HB6 Alpha beta hydrolase EYD11_17640 ENOG4105MI0 Catalyzes the non-heme iron(II)-dependent oxidative cleavage of 2,3-dihydroxyphenylpropionic acid and 2,3- dihydroxicinnamic acid into 2-hydroxy-6-ketononadienedioate and 2- hydroxy-6-ketononatrienedioate, respectively (By similarity) EYD11_17645 ENOG4105E2Q 3-(3-hydroxy-phenyl)propionate hydroxylase EYD11_17650 ENOG4108K2P TRANSCRIPTIONal EYD11_17655 ENOG4105ETE Transcriptional regulator (LacI family EYD11_17660 ENOG4105CNT hydrolase family 2 EYD11_17665 ENOG4105U0F oligosaccharide H symporter, major facilitator superfamily (MFS) EYD11_17670 ENOG4108UW5 maltose o-acetyltransferase EYD11_17675 ENOG4105DJ2 Major Facilitator Superfamily EYD11_17680 ENOG4108V7B Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide (By similarity) EYD11_17685 ENOG4107B2H carbonic anhydrase EYD11_17690 ENOG4105DND Transcriptional regulator EYD11_17695 ENOG4105DZC cytosine deaminase EYD11_17700 ENOG4105DQW permease for cytosine purines, uracil, thiamine, allantoin EYD11_17705 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) EYD11_17710 ENOG4105DXD 2-methylcitrate dehydratase EYD11_17715 ENOG4105BZN citrate synthase EYD11_17720 ENOG4105CR4 methylisocitrate lyase EYD11_17725 ENOG4108JU7 Transcriptional regulator EYD11_17730 ENOG4105TDT uncharacterized protein yahO EYD11_17735 ENOG4105E82 cytochrome subunit of dehydrogenase EYD11_17750 ENOG4105DQ4 alcohol dehydrogenase EYD11_17755 ENOG4105DZC cytosine deaminase EYD11_17760 ENOG4105C5B carbamate kinase EYD11_17770 ENOG4107REC cytoplasmic protein EYD11_17775 ENOG4107R1Q Membrane protein FdrA EYD11_17780 ENOG4105N16 Protein of unknown function (DUF2877) EYD11_17785 ENOG4107SNB ankyrin repeat protein YahD EYD11_17790 ENOG4105SZ2 membrAne EYD11_17795 ENOG4108NUU Transcriptional regulator EYD11_17800 ENOG4105BZU Histidine kinase EYD11_17810 ENOG4105C94 Transporter EYD11_17815 ENOG4108MHR Repressor involved in choline regulation of the bet genes (By similarity) EYD11_17820 ENOG4105C26 Dehydrogenase EYD11_17825 ENOG4105CZ6 Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine (By similarity) EYD11_17835 ENOG4108ZZK Is involved in L-lactate degradation and allows cells to grow with lactate as the sole carbon source (By similarity) EYD11_17840 ENOG4107QR9 Iron-sulfur cluster binding protein EYD11_17845 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) EYD11_17850 ENOG4108K01 transcriptional regulator EYD11_17855 ENOG4107QN2 dihydrolipoyl dehydrogenase EYD11_17860 ENOG41066GK UPF0379 protein ykgI EYD11_17865 ENOG4108KBJ Inner membrane protein YkgB EYD11_17895 ENOG4105NRA 50s ribosomal protein l31 type b EYD11_17910 ENOG4106JB4 Represses expression of the flagellar master operon flhDC, and consequently prevents flagellum biosynthesis and motility. Acts by binding to the regulatory region of the flhDC operon EYD11_17915 ENOG4108GWT fimbrillin MatB EYD11_17925 ENOG4108N3D putative enzyme EYD11_17930 ENOG4106PYX Receptor EYD11_17935 ENOG4108UD7 cell wall organization EYD11_17940 ENOG4105PI0 Ferredoxin EYD11_17945 ENOG4105R3P Inner membrane protein yagU EYD11_17950 ENOG4107XKX isoquinoline 1-oxidoreductase, alpha subunit EYD11_17955 ENOG4105DIP Molybdopterin dehydrogenase FAD-binding EYD11_17960 ENOG4105C7W Xanthine dehydrogenase EYD11_17965 ENOG4107XAN XdhC and CoxI family EYD11_18045 ENOG4105DFP Integrase EYD11_18065 ENOG4105FCK Membrane EYD11_18085 ENOG4105CIN aminoacyl-histidine dipeptidase EYD11_18090 ENOG4108S2Y peptide Chain Release factor EYD11_18100 ENOG4108HYG acetyltransferase EYD11_18105 ENOG41065DM this blockage is overcome by subsequent expression of antitoxin YafN. Overexpression causes cleavage of a number of mRNAs in a ribosome-dependent fashion. YafO binding to the 50S ribosomal subunit in the translation complex induces mRNA cleavage 3' to the region protected by the ribosome EYD11_18110 ENOG4105UG9 Antitoxin of the YafO-YafN toxin-antitoxin system EYD11_18115 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) EYD11_18130 ENOG4108UK5 Transposase EYD11_18135 ENOG4108YS0 lipoprotein YafL EYD11_18140 ENOG4105QHH Antitoxin component of a toxin-antitoxin (TA) module. A labile antitoxin that counteracts the effect of the YafQ toxin. YafQ and DinJ together bind their own promoter, and by analogy to other TA modules probably repress its expression EYD11_18145 ENOG4105VXN addiction module toxin, RelE StbE family EYD11_18150 ENOG4105F7V ErfK ybiS ycfS ynhG family protein EYD11_18155 ENOG4105E7A Glutamine amidotransferase EYD11_18165 ENOG4107QPN acyl-Coa dehydrogenase EYD11_18170 ENOG4108WN0 inhibitor of vertebrate lysozyme EYD11_18175 ENOG4105CZ7 nitrilase cyanide hydratase and apolipoprotein n-acyltransferase EYD11_18180 ENOG410600T transposase EYD11_18190 ENOG4105CNA YD repeat protein EYD11_18195 ENOG4105CS6 Rhs element vgr protein EYD11_18200 ENOG4108WC9 type VI secretion system effector, hcp1 family EYD11_18255 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit EYD11_18280 ENOG4105GMB type VI secretion system effector, hcp1 family EYD11_18295 ENOG410600K aminopeptidase EYD11_18305 ENOG4107RZZ dna polymerase iii epsilon subunit EYD11_18315 ENOG4105D1A Methyltransferase EYD11_18320 ENOG4108RW0 Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid (By similarity) EYD11_18325 ENOG4105E9H Lytic Murein transglycosylase EYD11_18330 ENOG4105F2W methyltransferase EYD11_18340 ENOG4105HEI LysR family (Transcriptional regulator EYD11_18345 ENOG4105CV8 reductase EYD11_18380 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase EYD11_18385 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) EYD11_18390 ENOG4108UMI ABC transporter, permease EYD11_18395 ENOG4105D01 (LipO)protein EYD11_18400 ENOG4108R8X outer membrane lipoprotein EYD11_18405 ENOG4108R96 Methyltransferase, YaeB family EYD11_18415 ENOG4108UY0 (LipO)protein EYD11_18420 ENOG4107EII Lipoprotein involved with copper homeostasis and adhesion EYD11_18425 ENOG4108YZN class I peptide chain release factor EYD11_18430 ENOG4108VWS Yaeq family EYD11_18440 ENOG4105M1T rho-binding antiterminator EYD11_18445 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) EYD11_18450 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase EYD11_18455 ENOG4105CXN decarboxylase EYD11_18465 ENOG4105C0B DNA polymerase III (alpha subunit) EYD11_18490 ENOG4105D7M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) EYD11_18495 ENOG4108RFI Molecular chaperone that interacts specifically with outer membrane proteins, thus maintaining the solubility of early folding intermediates during passage through the periplasm (By similarity) EYD11_18505 ENOG4105DZP Membrane-associated zinc metalloprotease EYD11_18510 ENOG4105KNE Phosphatidate cytidylyltransferase EYD11_18515 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) EYD11_18520 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) EYD11_18545 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) EYD11_18560 ENOG4105DIN metallophosphoesterase EYD11_18575 ENOG4108IXP Carbohydrate diacid transcriptional activator CdaR EYD11_18580 ENOG4105C0H protease EYD11_18595 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) EYD11_18600 ENOG4105EN6 Membrane EYD11_18625 ENOG4105S6R Iron-hydroxamate transporter permease subunit EYD11_18630 ENOG4105J76 Periplasmic binding protein EYD11_18635 ENOG4105E0A ABC, transporter EYD11_18640 ENOG4105E0K tonB-dependent siderophore receptor EYD11_18645 ENOG4105BZ4 penicillin-binding protein EYD11_18650 ENOG4105CQ7 ATP-dependent helicase EYD11_18655 ENOG4107XID 2'-5' rna ligase EYD11_18665 ENOG4108V7X Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters EYD11_18675 ENOG4105DJ0 Poly(A) Polymerase EYD11_18680 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase EYD11_18690 ENOG4108VEV chaperone EYD11_18695 ENOG4105CW0 outer membrane usher protein EYD11_18700 ENOG4108XEY fimbrial-like adhesin protein EYD11_18705 ENOG4105SYG Fimbrial protein EYD11_18710 ENOG4105SN2 fimbrial-like adhesin protein EYD11_18715 ENOG4105P0Q fimbrial-like protein YadC EYD11_18730 ENOG4108A32 Transposase EYD11_18740 ENOG4107BJW polysaccharide deacetylase EYD11_18745 ENOG4108YTN IIa component EYD11_18750 ENOG4105E3A (ABC) transporter EYD11_18755 ENOG4105DA5 (ABC) transporter EYD11_18760 ENOG41077A9 carbonic anhydrase EYD11_18765 ENOG4108UGV hypoxanthine phosphoribosyltransferase EYD11_18770 ENOG4105DZG Dehydrogenase EYD11_18775 ENOG4105E3B Multicopper oxidase EYD11_18780 ENOG4108ZRK uncharacterized protein yacC EYD11_18800 ENOG4107QIJ Aconitate hydratase 2 EYD11_18805 ENOG4108NST exported protein EYD11_18810 ENOG4107QN2 dihydrolipoyl dehydrogenase EYD11_18815 ENOG4107QSN dihydrolipoamide acetyltransferase EYD11_18820 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) EYD11_18825 ENOG41073TP transcriptional regulator EYD11_18830 ENOG4105C85 amino acid EYD11_18835 ENOG4106A72 regulatory protein AmpE EYD11_18840 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase EYD11_18845 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase EYD11_18850 ENOG4108ZUW Major pilin subunit EYD11_18855 ENOG4107QHF type ii secretion system protein e EYD11_18860 ENOG4105D7Q type ii secretion system EYD11_18870 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) EYD11_18885 ENOG4105M6F mutator MutT protein EYD11_18905 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) EYD11_18910 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) EYD11_18915 ENOG4105K7E Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity) EYD11_18920 ENOG4105CPF Cell wall formation (By similarity) EYD11_18935 ENOG4105CNI cell division protein FtsW EYD11_18950 ENOG4108EQQ Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity) EYD11_18955 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) EYD11_18960 ENOG4105CJN penicillin-binding protein EYD11_18965 ENOG41063Y6 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) EYD11_18975 ENOG4108V6E Cell division protein mraZ EYD11_18980 ENOG4107B7Y DNA-binding transcriptional regulator FruR EYD11_18990 ENOG4108ZP8 Acetolactate synthase small subunit EYD11_18995 ENOG4105C7K acetolactate synthase EYD11_19005 ENOG41064T2 transcriptional regulator, lysR family EYD11_19020 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) EYD11_19035 ENOG4105S8Q sugar efflux transporter EYD11_19045 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) EYD11_19050 ENOG4105DP9 ABC transporter EYD11_19055 ENOG4106SMU thiamine transporter membrane protein EYD11_19060 ENOG4107T0D ABC, transporter EYD11_19065 ENOG4108KF1 Membrane EYD11_19070 ENOG41063TF transcriptional regulator (AraC EYD11_19075 ENOG4105EF1 ribulokinase EYD11_19080 ENOG4105CAC Catalyzes the conversion of L-arabinose to L-ribulose (By similarity) EYD11_19085 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase EYD11_19090 ENOG4105CQ2 DNA polymerase EYD11_19100 ENOG4105D3G Pseudouridine synthase EYD11_19120 ENOG41066UG Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host (By similarity) EYD11_19125 ENOG4105E7H involved in the assembly of LPS in the outer leaflet of the outer membrane. Determines N-hexane tolerance and is involved in outer membrane permeability. Essential for envelope biogenesis (By similarity) EYD11_19130 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) EYD11_19155 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) EYD11_19170 ENOG4105C54 Major Facilitator superfamily EYD11_19175 ENOG4105IBM Could be part of an electron transfer system required for anaerobic carnitine reduction. Could be a 3Fe-4S cluster- containing protein EYD11_19180 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase EYD11_19215 ENOG4106YT9 Enoyl-CoA hydratase EYD11_19225 ENOG4108XNW Transcriptional activatory protein CaiF EYD11_19230 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain EYD11_19235 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain EYD11_19255 ENOG41090X3 Peptidyl-prolyl cis-trans isomerase EYD11_19265 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) EYD11_19270 ENOG4105DTN riboflavin biosynthesis protein ribF EYD11_19275 ENOG410647N response to DNA damage stimulus EYD11_19300 ENOG41063Z6 transcriptional regulator, lysR family EYD11_19315 ENOG4105WI6 cell killing protein encoded within cryptic prophage EYD11_19320 ENOG4108SER Transposase EYD11_19340 ENOG4108QUJ UPF0174 protein YaaW EYD11_19345 ENOG4106HK8 GPR1 FUN34 yaaH family protein EYD11_19350 ENOG4108RIR Molybdenum cofactor biosynthesis protein EYD11_19360 ENOG4105BZG amino acid carrier protein EYD11_19365 ENOG4105D1Q UPF0246 protein EYD11_19370 ENOG41062C6 Protein of unknown function (DUF2502) EYD11_19375 ENOG4105D98 threonine synthase EYD11_19385 ENOG4105CFH Aspartokinase EYD11_19395 ENOG4106FVC RNA methyltransferase EYD11_19400 ENOG410759A EYD11_19405 ENOG41065U4 response regulator EYD11_19410 ENOG4105CT7 inner membrane cred family protein EYD11_19415 ENOG4105EB3 Histidine kinase EYD11_19420 ENOG4105E3W Two component transcriptional regulator (Winged helix family EYD11_19425 ENOG4108RH0 Crea protein EYD11_19430 ENOG4105UEI Transcriptional Regulator AraC Family EYD11_19450 ENOG4107SC1 transglycosylase EYD11_19455 ENOG4105C5H ABC transporter EYD11_19460 ENOG4107VZS Nicotinamide-nucleotide adenylyltransferase EYD11_19465 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) EYD11_19470 ENOG4105EAC phosphoserine phosphatase EYD11_19475 ENOG4107RMF Catalyzes both the ATP-dependent activation of exogenously supplied lipoate to lipoyl-AMP and the transfer of the activated lipoyl onto the lipoyl domains of lipoate-dependent enzymes (By similarity) EYD11_19505 ENOG4105G0K glycine radical enzyme YjjI family EYD11_19510 ENOG41076CZ activating enzyme EYD11_19515 ENOG4105EYA deoxyribonuclease EYD11_19520 ENOG4108NRW Phospholipase, patatin family EYD11_19530 ENOG4105K3G Periplasmic Protein EYD11_19540 ENOG4105PAD Hydrolase EYD11_19545 ENOG4105KEG ribosomal-protein-alanine acetyltransferase EYD11_19550 ENOG4108WPU DNA polymerase III subunit psi EYD11_19555 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) EYD11_19575 ENOG4105YBH Protein of unknown function (DUF1435) EYD11_19580 ENOG4108819 ferric iron reductase EYD11_19585 ENOG4108T94 DNA-binding transcriptional activator BglJ EYD11_19590 ENOG4108N8T regulatoR EYD11_19595 ENOG4105DWK Membrane EYD11_19610 ENOG4106CVF DNA replication protein EYD11_19615 ENOG4105RI1 glycoprotein receptor EYD11_19625 ENOG4105CPQ Dehydrogenase EYD11_19630 ENOG410617M Transcriptional regulator EYD11_19635 ENOG4108I5G Major Facilitator superfamily EYD11_19640 ENOG4105C8Q Methyl-accepting chemotaxis EYD11_19645 ENOG4105D22 carbon starvation protein EYD11_19650 ENOG4105VCD cytoplasmic protein EYD11_19655 ENOG4105CKI cobalamin synthesis protein EYD11_19675 ENOG41083G8 Multidrug resistance protein MdtM EYD11_19680 ENOG4106BRA Membrane EYD11_19685 ENOG4105DCU 2-hydroxyglutaryl-CoA dehydratase EYD11_19690 ENOG4105CIZ coA-substrate-specific enzyme activase EYD11_19705 ENOG4105CBP Major Facilitator EYD11_19715 ENOG41074DU domain protein EYD11_19720 ENOG4108P2H Inner membrane protein YjiG EYD11_19725 ENOG4105DYB Isoaspartyl dipeptidase EYD11_19730 ENOG4107YNJ LysR family Transcriptional regulator EYD11_19750 ENOG4105C6F GntR Family Transcriptional Regulator EYD11_19755 ENOG4105DEI Mannitol dehydrogenase EYD11_19765 ENOG4107EFN gluconate transport system permease 3 EYD11_19770 ENOG410643X FIMH SUBUNIT MANNOSE-sensitive type 1 fimbrial adhesin EYD11_19785 ENOG41069FU Outer membrane channel protein allowing the entry of N- acetylneuraminic acid (Neu5Ac, the most abundant sialic acid on host cell surfaces) into the bacteria EYD11_19815 ENOG4108YXQ IS66 Orf2 family protein EYD11_19820 ENOG4105E5H Transposase EYD11_19860 ENOG4108SF5 RNA Polymerase EYD11_19865 ENOG4108S3W Anti-feci sigma factor, fecr EYD11_19870 ENOG4105GAV receptor EYD11_19875 ENOG4108HUF Transporter EYD11_19880 ENOG4105DQ5 transport system permease protein EYD11_19885 ENOG4108IHU transport system permease protein EYD11_19890 ENOG4105E0A ABC, transporter EYD11_19905 ENOG4105EKQ RNA-directed DNA polymerase EYD11_19925 ENOG4108WUH Transcriptional regulator, TetR family EYD11_19935 ENOG4105EXU Membrane EYD11_19945 ENOG4105C94 Transporter EYD11_19955 ENOG4105NWR lipid A biosynthesis (Kdo)2-(Lauroyl)-lipid IVA acyltransferase EYD11_19960 ENOG4108MJ5 VirK protein EYD11_19965 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) EYD11_19970 ENOG4107BJW polysaccharide deacetylase EYD11_19985 ENOG4105EKQ RNA-directed DNA polymerase EYD11_20000 ENOG4107RRE RNA-directed DNA polymerase EYD11_20075 ENOG4105DQ4 alcohol dehydrogenase EYD11_20080 ENOG4105D7A ATP-binding protein EYD11_20085 ENOG4108K5H permease YjgP YjgQ family protein EYD11_20090 ENOG4108M8S permease YjgP YjgQ family protein EYD11_20100 ENOG4105MYG DNA polymerase iii, chi subunit EYD11_20105 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) EYD11_20110 ENOG4108M3P Membrane EYD11_20115 ENOG4108MJ3 acetyltransferase EYD11_20120 ENOG4105KQT Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome (By similarity) EYD11_20135 ENOG4105XEP YhcH YjgK YiaL family protein EYD11_20140 ENOG4108XFH Transcriptional regulator EYD11_20145 ENOG4105F6U Short-chain dehydrogenase reductase Sdr EYD11_20150 ENOG4108UQ8 endoribonuclease L-psp EYD11_20155 ENOG41077AM PyrBI operon attenuator EYD11_20170 ENOG4105KME endoribonuclease L-psp EYD11_20175 ENOG4105C52 Atpase, p-type (Transporting), had superfamily, subfamily ic EYD11_20185 ENOG4105D4X repressor EYD11_20190 ENOG4105C5Y PTS System EYD11_20195 ENOG4105CG3 alpha amylase, catalytic region EYD11_20200 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase EYD11_20205 ENOG4108RDD Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine (By similarity) EYD11_20215 ENOG4105CMS peptidase U62, modulator of DNA gyrase EYD11_20225 ENOG4105DFU Cell wall formation (By similarity) EYD11_20235 ENOG41062B0 ABC transporter, permease EYD11_20240 ENOG4107R9N ABC transporter EYD11_20245 ENOG4105C2J ABC transporter EYD11_20250 ENOG4107R5U Periplasmic binding protein LacI transcriptional regulator EYD11_20255 ENOG4105F0N pyrophosphate phospho-hydrolase EYD11_20260 ENOG4105MZG transcriptional modulator of maze toxin, mazf EYD11_20265 ENOG41087RY SpoVT_AbrB EYD11_20270 ENOG4108ZHD aig2 family EYD11_20275 ENOG4105MA0 exported protein EYD11_20280 ENOG4105CFU surface antigen EYD11_20290 ENOG4105C37 (CBS) domain EYD11_20295 ENOG41061GZ Protein of unknown function (DUF1107) EYD11_20300 ENOG4108UUE Transcriptional regulator EYD11_20310 ENOG4108RNI 3'(2')5'-bisphosphate nucleotidase EYD11_20315 ENOG4107RNS bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase 3'-nucleotidase periplasmic EYD11_20320 ENOG4105KVH Transcriptional regulator EYD11_20325 ENOG4105ECR NmrA family EYD11_20330 ENOG4105DXC membrane EYD11_20340 ENOG4105C85 amino acid EYD11_20345 ENOG4108V1T peptidylprolyl cis-trans isomerase EYD11_20355 ENOG4105FHY Opacity-associated protein A EYD11_20365 ENOG4105D7V transposase EYD11_20370 ENOG4108RS6 transposase EYD11_20390 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) EYD11_20405 ENOG4105KIT UPF0379 protein yjfY EYD11_20410 ENOG4105R3P Inner membrane protein yagU EYD11_20415 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase EYD11_20430 ENOG4106ETB IIa component EYD11_20435 ENOG410907W The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in ascorbate transport EYD11_20455 ENOG4108MXZ Esterase EYD11_20460 ENOG4105WSB biofilm stress and motility protein A EYD11_20465 ENOG4105S17 UPF0379 protein yjfN EYD11_20470 ENOG4105CSU acyl-Coa dehydrogenase EYD11_20475 ENOG4106032 Glutathionylspermidine synthase EYD11_20480 ENOG4108KXT Conserved Protein EYD11_20485 ENOG4105Z6B inner membrane protein yjfl EYD11_20490 ENOG4107VNS Protein of unknown function (DUF2491) EYD11_20505 ENOG4105CTX dehydratase EYD11_20510 ENOG4105CSP Major Facilitator Superfamily EYD11_20515 ENOG4105CDP Catalyzes the condensation of (S)-aspartate-beta- semialdehyde (S)-ASA and pyruvate to 4-hydroxy- tetrahydrodipicolinate (HTPA) (By similarity) EYD11_20520 ENOG4107HP6 Transcriptional regulator EYD11_20525 ENOG4105C2N RNA methyltransferase TrmH family group 3 EYD11_20535 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) EYD11_20555 ENOG4105EPW hflc protein EYD11_20560 ENOG4107QJR hflk protein EYD11_20565 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) EYD11_20570 ENOG4105KW8 RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs (By similarity) EYD11_20585 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase EYD11_20590 ENOG4105K8N protein family UPF0079, ATPase EYD11_20595 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) EYD11_20600 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) EYD11_20640 ENOG4105EGS Mechanosensitive ion channel EYD11_20645 ENOG4106CG8 Inner membrane protein YjeO EYD11_20650 ENOG4106V5W EYD11_20655 ENOG4107SC7 Inner membrane transporter yjeM EYD11_20660 ENOG4105CAP With EpmB is involved in the beta-lysylation step of the post-translational modification of translation elongation factor P (EF-P). Catalyzes the ATP-dependent activation of (R)-beta-lysine produced by EpmB, forming a lysyl-adenylate, from which the beta- lysyl moiety is then transferred to the epsilon-amino group of a conserved specific lysine residue in EF-P (By similarity) EYD11_20665 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) EYD11_20670 ENOG4105E33 succinate dehydrogenase EYD11_20685 ENOG41066YJ Beta-lactamase EYD11_20690 ENOG4105QNF Outer membrane lipoprotein EYD11_20695 ENOG4105KPY Small multidrug resistance protein EYD11_20700 ENOG4106BSU Entericidin B EYD11_20705 ENOG4106HKS Entericidin EcnA/B family EYD11_20715 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein EYD11_20720 ENOG4105MTB Uncharacterized protein YjeJ EYD11_20725 ENOG4108ZVF (LipO)protein EYD11_20740 ENOG4105DVH amino acid EYD11_20745 ENOG4108YH1 overproduction of this protein in Escherichia coli inhibits the F plasmid-mediated exclusion of bacteriophage T7 EYD11_20750 ENOG4108IJ0 Aspartate ammonia-lyase EYD11_20755 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter EYD11_20765 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) EYD11_20770 ENOG4108SIC Transcriptional regulator EYD11_20780 ENOG4108M3R transcriptional activator CadC EYD11_20785 ENOG4105D5Q Arginine ornithine antiporter EYD11_20790 ENOG4105CXN decarboxylase EYD11_20795 ENOG4105DUX Transporter EYD11_20800 ENOG4105CRK lysyL-tRNA synthetase EYD11_20815 ENOG410830R acetyltransferase EYD11_20820 ENOG4105VR1 Pfam:DUF1271 EYD11_20825 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism EYD11_20830 ENOG4108MRH transcriptional regulatory protein EYD11_20835 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter EYD11_20840 ENOG4107GFK fumarate EYD11_20845 ENOG4108R5S membrane EYD11_20850 ENOG4105CT4 transporter EYD11_20855 ENOG4105F8D glycoside hydrolase family 4 EYD11_20860 ENOG4108K2B transcriptional regulator EYD11_20865 ENOG4105CXN decarboxylase EYD11_20870 ENOG4106ZGR Transcriptional regulator EYD11_20875 ENOG4105D5Q Arginine ornithine antiporter EYD11_20880 ENOG4105DIJ Phosphoethanolamine transferase EYD11_20885 ENOG4105XJC Two component transcriptional regulator (Winged helix family EYD11_20890 ENOG4105ECM Sensor protein basS pmrB EYD11_20900 ENOG4105CSH Transporter EYD11_20905 ENOG4108YIV EYD11_20915 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA EYD11_20920 ENOG4108SQ4 Glyoxalase Bleomycin resistance protein (Dioxygenase EYD11_20925 ENOG4105D5T phosphonate abc transporter EYD11_20930 ENOG4105EHI Phosphonate ABC transporter, periplasmic EYD11_20940 ENOG4107RJJ Transcriptional regulator EYD11_20945 ENOG4105KQZ Phosphonate C-P lyase system protein PhnG EYD11_20950 ENOG4105KZ6 phosphonate C-P lyase system protein PhnH EYD11_20955 ENOG4105EKV Phosphonate metabolism protein EYD11_20960 ENOG4105FT8 Phosphonate metabolism EYD11_20965 ENOG4105ENV phosphonate C-P lyase system protein PhnK EYD11_20970 ENOG4105HRV phosphonate c-p lyase system protein phnl EYD11_20975 ENOG4105FD8 phosphonate metabolism protein PhnM EYD11_20980 ENOG4105MFQ Catalyzes the phosphorylation of ribose 1,5-bisphosphate to 5-phospho-D-ribosyl alpha-1-diphosphate (PRPP) (By similarity) EYD11_20985 ENOG410849A acetyltransferase, (GNAT) family EYD11_20990 ENOG4107SA6 carbon-phosphorus lyase complex accessory protein EYD11_20995 ENOG4106ZVZ Escherichia coli IMT2125 genomic chromosome, IMT2125 EYD11_21000 ENOG4108YZG isomerase EYD11_21005 ENOG4105NYY transcriptional regulator, RpiR EYD11_21010 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator EYD11_21015 ENOG4105C2J ABC transporter EYD11_21020 ENOG4105CNN ABC, transporter EYD11_21025 ENOG4105UP7 3-epimerase EYD11_21030 ENOG4107TFG D-allose kinase EYD11_21035 ENOG4105EUZ Beta-lactamase domain protein EYD11_21040 ENOG4106833 EYD11_21045 ENOG4105J12 Multidrug resistance protein mdtN EYD11_21050 ENOG4108MI0 Resistance protein EYD11_21055 ENOG4105ETP RND efflux system, outer membrane lipoprotein EYD11_21065 ENOG41082ND Uncharacterized protein yjcO EYD11_21070 ENOG4105CK2 sodium dicarboxylate symporter EYD11_21075 ENOG4108W0S formate-dependent nitrite reductase complex EYD11_21085 ENOG4108QKW cytochrome c-type biogenesis protein EYD11_21090 ENOG4105DVI reductase, NrfD EYD11_21095 ENOG4105D3S 4Fe-4S Ferredoxin, iron-sulfur binding domain protein EYD11_21100 ENOG4105JJ8 Cytochrome c nitrite reductase, pentaheme subunit EYD11_21110 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) EYD11_21115 ENOG41062QD Membrane EYD11_21130 ENOG4105EEQ Na H antiporter EYD11_21135 ENOG4105C7N Xanthine uracil vitamin C permease EYD11_21140 ENOG4108Z4X TRANSCRIPTIONal EYD11_21145 ENOG4108W3Q Transcriptional regulator EYD11_21150 ENOG4108M8H domain protein EYD11_21155 ENOG4105PMV Membrane EYD11_21190 ENOG4108FPN Integrase EYD11_21195 ENOG4108UUM single-stranded DNA-binding protein EYD11_21200 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) EYD11_21205 ENOG4105MSB protein, conserved in bacteria EYD11_21210 ENOG4108YXI Secondary thiamine-phosphate synthase enzyme EYD11_21215 ENOG4105F0S class B acid phosphatase EYD11_21225 ENOG4105CGF Aromatic amino acid aminotransferase EYD11_21230 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) EYD11_21235 ENOG4105CDU Replicative dna helicase EYD11_21240 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein EYD11_21245 ENOG4105P4Z Phage shock protein G EYD11_21250 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) EYD11_21265 ENOG4105MYN Zinc uptake regulation protein EYD11_21270 ENOG4105VDW Csbd family EYD11_21275 ENOG4107R73 Mate efflux family protein EYD11_21285 ENOG41080IJ Diacylglycerol kinase EYD11_21310 ENOG4107W52 maltose operon periplasmic protein EYD11_21320 ENOG4108IJ9 (ABC) transporter EYD11_21325 ENOG4107FKK extracellular solute-binding protein family 1 EYD11_21350 ENOG4105D56 permease protein EYD11_21355 ENOG4105EG2 ABC transporter, permease EYD11_21360 ENOG4107QNK )-transporter EYD11_21375 ENOG4105E3R (LipO)protein EYD11_21380 ENOG4108Q9C Periplasmic Protein EYD11_21385 ENOG4108MDC (LipO)protein EYD11_21405 ENOG4105CFH Aspartokinase EYD11_21410 ENOG4108ZR5 Conserved Protein EYD11_21415 ENOG4105FE9 pseudouridine synthase EYD11_21425 ENOG4105EAM Na Pi-cotransporter EYD11_21430 ENOG4105C3R Methionine synthase EYD11_21435 ENOG41069M3 Transcriptional regulator EYD11_21450 ENOG4108I9X Isocitrate lyase EYD11_21455 ENOG4107QP3 malate synthase g EYD11_21460 ENOG4105CVG Homoserine O-transsuccinylase EYD11_21465 ENOG4105K5X acetyltransferase EYD11_21470 ENOG41062WK cellular response to acidity EYD11_21500 ENOG4105C12 Phosphoribosylglycinamide synthetase EYD11_21505 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family EYD11_21510 ENOG4105BZU Histidine kinase EYD11_21515 ENOG4105JBU Binds zinc. Could be an important component of the zinc- balancing mechanism EYD11_21520 ENOG4108T8B Protein of unknown function (DUF1481) EYD11_21525 ENOG4105K70 DNA-binding protein EYD11_21530 ENOG4105R2J Conserved Protein EYD11_21565 ENOG4105D06 uba thif-type nad fad binding protein EYD11_21570 ENOG4105WHD thiamine biosynthesis protein ThiS EYD11_21580 ENOG4105D41 biosynthesis protein thiH EYD11_21585 ENOG410645W Thiamin biosynthesis protein ThiH EYD11_21620 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) EYD11_21625 ENOG4105PM1 preprotein translocase subunit SecE EYD11_21660 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase EYD11_21665 ENOG4105D4A Cell wall formation (By similarity) EYD11_21695 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) EYD11_21705 ENOG4108Y73 Membrane EYD11_21710 ENOG4105EJ2 Transcriptional regulator EYD11_21720 ENOG4105C5Q Transcriptional regulator EYD11_21730 ENOG4105CAS nag kinase EYD11_21735 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase EYD11_21750 ENOG4105DIJ Phosphoethanolamine transferase EYD11_21755 ENOG4106R3P AraC family transcriptional regulator EYD11_21760 ENOG4108XCZ PTS System EYD11_21765 ENOG4108AHH pyruvate formate lyase II activase EYD11_21770 ENOG4105C6N Formate acetyltransferase EYD11_21775 ENOG4108YRF PTS System EYD11_21780 ENOG4105DM4 PTS System EYD11_21785 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) EYD11_21790 ENOG4107T9Z Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) EYD11_21795 ENOG4105DCT glycerol dehydrogenase EYD11_21800 ENOG4108XC3 NADH ubiquinone oxidoreductase EYD11_21805 ENOG4108Q5Y Membrane EYD11_21810 ENOG4105C1X Bifunctional enzyme with both catalase and broad- spectrum peroxidase activity (By similarity) EYD11_21815 ENOG4105SYT Methylenetetrahydrofolate reductase EYD11_21820 ENOG4105CFH Aspartokinase EYD11_21825 ENOG4105C28 cystathionine EYD11_21835 ENOG4107S01 Repressor protein MetJ EYD11_21845 ENOG4105C25 Primosomal protein n' EYD11_21850 ENOG4105ETE Transcriptional regulator (LacI family EYD11_21855 ENOG41063M6 Cell Division Protein EYD11_21865 ENOG4105C4N this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis (By similarity) EYD11_21870 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase EYD11_21885 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) EYD11_21895 ENOG4105CBT Fructose-1,6-bisphosphatase EYD11_21900 ENOG4105DP0 ferredoxin-NADP reductase EYD11_21910 ENOG41065TG regulatoR EYD11_21915 ENOG4108VTS Membrane EYD11_21920 ENOG4105EBK exported protein EYD11_21935 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein EYD11_21960 ENOG4105ZTC transcriptional activator, Ogr delta EYD11_22000 ENOG4108C33 Resolvase EYD11_22005 ENOG4105E5H Transposase EYD11_22010 ENOG4108YXQ IS66 Orf2 family protein EYD11_22030 ENOG4108US3 tail fiber assembly EYD11_22035 ENOG4105UZW Tail fiber assembly protein EYD11_22130 ENOG4105ED4 portal protein EYD11_22150 ENOG4105F5W AtP-binding protein EYD11_22155 ENOG4105D70 Integrase catalytic subunit EYD11_22200 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) EYD11_22205 ENOG4105FMW periplasmic EYD11_22210 ENOG4105E3W Two component transcriptional regulator (Winged helix family EYD11_22215 ENOG4105E0F Histidine kinase EYD11_22220 ENOG4108RPX mosc domain containing protein EYD11_22230 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) EYD11_22270 ENOG41064BA PTS system, fructose-specific, IIA component EYD11_22275 ENOG4105DM4 PTS System EYD11_22280 ENOG4105CN9 Peptidase m42 family protein EYD11_22285 ENOG4106C3V frv operon regulatory protein EYD11_22290 ENOG4108V87 frv operon regulatory protein EYD11_22300 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) EYD11_22305 ENOG4107QIW Catalytic subunit of the periplasmic nitrate reductase (NAP). Only expressed at high levels during aerobic growth. NapAB complex receives electrons from the membrane-anchored tetraheme protein NapC, thus allowing electron flow between membrane and periplasm. Essential function for nitrate assimilation and may have a role in anaerobic metabolism (By similarity) EYD11_22310 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein EYD11_22315 ENOG4108MG3 formate dehydrogenase EYD11_22325 ENOG41068KX affects formate dehydrogenase-N EYD11_22330 ENOG4106UEE Transcriptional regulator EYD11_22335 ENOG4105SUU thioesterase domain EYD11_22350 ENOG4105EJU HAD-superfamily hydrolase subfamily IA variant 3 EYD11_22355 ENOG4105E98 transcriptional regulator DeoR family EYD11_22360 ENOG4108MGF sugar kinase EYD11_22365 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase EYD11_22370 ENOG4105D2M Aldolase EYD11_22375 ENOG4107QKS N-acylglucosamine 2-epimerase EYD11_22380 ENOG4107WI4 Aldose-1-epimerase EYD11_22385 ENOG4105CJQ hydrolase, family 31 EYD11_22390 ENOG4105CT4 transporter EYD11_22395 ENOG4105CT4 transporter EYD11_22400 ENOG4108KUC Outer membrane channel protein that allows an efficient diffusion of low-molecular-weight solutes such as small sugars and tetraglycine. However, the specific substrate recognized by the OmpL channel is EYD11_22405 ENOG4105R9B Major Facilitator EYD11_22410 ENOG4108KHF Resistance protein EYD11_22415 ENOG4108K85 Transcriptional regulator EYD11_22425 ENOG4105C5F glutamine synthetase EYD11_22430 ENOG4105CUX Signal transduction histidine kinase EYD11_22435 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family EYD11_22440 ENOG4106FIY EYD11_22445 ENOG4105D4P Coproporphyrinogen iii oxidase EYD11_22460 ENOG4105C2M dna polymerase I EYD11_22470 ENOG4106HNH Acyl-transferase EYD11_22480 ENOG4108Z33 Thiol disulfide Interchange Protein EYD11_22485 ENOG4105E27 serine threonine protein kinase EYD11_22490 ENOG4105PC1 Conserved Protein EYD11_22495 ENOG4105C6R Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) EYD11_22500 ENOG4105FNP Molybdopterin-guanine dinucleotide biosynthesis protein b EYD11_22530 ENOG4108RR8 protoporphyrinogen oxidase EYD11_22535 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) EYD11_22540 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein EYD11_22555 ENOG4105CHU acetyl-coa acetyltransferase EYD11_22560 ENOG4107QK7 reductase EYD11_22565 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) EYD11_22570 ENOG4105MDZ Transcriptional activator rfaH EYD11_22575 ENOG4105F8V Hydrolase, tatD family EYD11_22580 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) EYD11_22585 ENOG4105X8U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity) EYD11_22590 ENOG4105WKS Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) EYD11_22600 ENOG4105JC1 sterol-binding domain protein EYD11_22610 ENOG4105CGY Dna recombination protein EYD11_22615 ENOG4108I5U Uridine phosphorylase EYD11_22620 ENOG4105CDZ Carboxymethylenebutenolidase (EC 3.1.1.45) EYD11_22625 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) EYD11_22630 ENOG4105DZ2 Transcriptional regulator EYD11_22635 ENOG4105EMK carboxylate amino acid amine transporter EYD11_22640 ENOG4105DQF Hydrolase EYD11_22645 ENOG4108EUD Lysophospholipase EYD11_22660 ENOG4105C9U ATP-dependent DNA helicase RecQ EYD11_22665 ENOG4105HDD phospholipase EYD11_22670 ENOG4108VUY thioesterase Superfamily protein EYD11_22675 ENOG4105FR1 rard protein EYD11_22680 ENOG4106WR8 Inner membrane protein YigG EYD11_22685 ENOG4105NRM Membrane EYD11_22690 ENOG4107QUT magnesium and cobalt transport protein CorA EYD11_22695 ENOG4108T58 Mg2 transport protein CorA EYD11_22700 ENOG4105C4R Atp-dependent dna helicase EYD11_22705 ENOG4105DFC had-superfamily hydrolase, subfamily ia, variant EYD11_22715 ENOG4105CT0 Protein of unknown function, DUF484 EYD11_22725 ENOG4105S7Z (LipO)protein EYD11_22740 ENOG4107T0K Adenylate cyclase EYD11_22750 ENOG41076E6 Uroporphyrinogen-III Synthase EYD11_22755 ENOG4105ECF c-methyltransferase EYD11_22760 ENOG410601J HemY protein EYD11_22765 ENOG4105ENH Sulfatase EYD11_22770 ENOG4105C4X radical SAM domain protein EYD11_22795 ENOG4105C85 amino acid EYD11_22810 ENOG4105F18 Catalyzes the synthesis of Und-PP-GlcNAc-ManNAcA-Fuc4NAc (Lipid III), the third lipid-linked intermediate involved in ECA synthesis (By similarity) EYD11_22815 ENOG4105EGZ biosynthesis protein EYD11_22820 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase EYD11_22825 ENOG4108WJ1 acetyltransferase EYD11_22830 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) EYD11_22835 ENOG4105C1B dTDP-glucose 4-6-dehydratase EYD11_22840 ENOG4108IJ1 Dehydrogenase EYD11_22845 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase EYD11_22850 ENOG4105SFE lipopolysaccharide biosynthesis protein EYD11_22855 ENOG4105ESV Glycosyl transferase, family 4 EYD11_22870 ENOG4105K63 Thioredoxin EYD11_22880 ENOG4105C9X ppx gppa phosphatase EYD11_22885 ENOG4105C4R Atp-dependent dna helicase EYD11_22895 ENOG4105KQ5 peptidylprolyl cis-trans isomerase EYD11_22905 ENOG4105EMY transcriptional regulator EYD11_22910 ENOG4105C7B Threonine dehydratase EYD11_22920 ENOG4105CM2 brancheD-chain amino acid aminotransferase EYD11_22925 ENOG4105P3Y Acetolactate synthase 2 regulatory subunit EYD11_22945 ENOG4105C0P Mg chelatase subunit ChlI EYD11_22950 ENOG4108WFC UPF0438 protein yifE EYD11_22990 ENOG4107EJG GntR family transcriptional regulator EYD11_22995 ENOG4105C0R drug resistance transporter emrb qaca subfamily EYD11_23000 ENOG4105ETE Transcriptional regulator (LacI family EYD11_23005 ENOG4108RVA ribokinase EYD11_23010 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator EYD11_23015 ENOG4105CNN ABC, transporter EYD11_23020 ENOG4105C2J ABC transporter EYD11_23025 ENOG4105MRB Catalyzes the interconversion of beta-pyran and beta- furan forms of D-ribose (By similarity) EYD11_23040 ENOG4105EV2 VWA domain protein interacting with AAA ATPase EYD11_23050 ENOG4108VVK transcriptional Regulator, AsnC EYD11_23055 ENOG4105QTB Flavodoxin EYD11_23070 ENOG4105GXX Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit I associates with the membrane and may be involved with cation translocation EYD11_23080 ENOG4105KY6 F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity) EYD11_23120 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) EYD11_23125 ENOG4107QMV Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity) EYD11_23130 ENOG4105C8U phosphate abc transporter EYD11_23135 ENOG4105E2Z phosphate ABC transporter (Permease EYD11_23140 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) EYD11_23145 ENOG4108UTW Plays a role in the regulation of phosphate uptake EYD11_23150 ENOG4105CID antiterminator EYD11_23155 ENOG4105C5Y PTS System EYD11_23160 ENOG4105CS2 ec 3.2.1.21 EYD11_23170 ENOG4105DYC esterase EYD11_23175 ENOG4107VKM 6-phosphogluconolactonase EYD11_23180 ENOG4106611 bacteriocin immunity EYD11_23190 ENOG4108YXQ IS66 Orf2 family protein EYD11_23195 ENOG4105E5H Transposase EYD11_23205 ENOG4106HGK Inner membrane protein yieI EYD11_23210 ENOG4107UB3 HAD-superfamily hydrolase subfamily IA variant 3 EYD11_23215 ENOG4105C7N Xanthine uracil vitamin C permease EYD11_23220 ENOG4108YYH Nadph-dependent fmn reductase EYD11_23225 ENOG4105E8Q phosphopantetheinyl transferase EYD11_23240 ENOG4108P6C Tryptophan transporter of low affinity EYD11_23285 ENOG4106JVB Replication Protein EYD11_23300 ENOG4108SER Transposase EYD11_23435 ENOG4105C4R Atp-dependent dna helicase EYD11_23575 ENOG4108M24 von Willebrand factor, type A EYD11_23580 ENOG4108M24 von Willebrand factor, type A EYD11_23610 ENOG4105DAX Pfam:DUF2983 EYD11_23700 ENOG4105CAF HipA N-terminal domain protein EYD11_23820 ENOG4108KTG Membrane protein, drug metabolite transporter EYD11_23865 ENOG4105IGJ Zn-dependent Hydrolase of the beta-lactamase fold protein EYD11_23915 ENOG4105C1P efflux transporter, rnd family, mfp subunit EYD11_23995 ENOG4105VUN Transcriptional regulator EYD11_24095 ENOG4105EKQ RNA-directed DNA polymerase EYD11_24115 ENOG4105DRC Na( ) H( ) antiporter that extrudes sodium in exchange for external protons (By similarity) EYD11_24135 ENOG4105T95 Thiol disulfide interChange protein EYD11_24190 ENOG4105F2I Transposase EYD11_24330 ENOG41074AV Hok/gef family EYD11_24495 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) EYD11_24520 ENOG4106JVB Replication Protein EYD11_24555 ENOG4105DFE Dna adenine methylase EYD11_24585 ENOG4108EHY type IV secretion system EYD11_24595 ENOG4105CMA conjugation trbi family protein EYD11_24695 ENOG4105BZ5 ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity) EYD11_24735 ENOG4107QJE Chromosome Partitioning Protein EYD11_24755 ENOG4105KT5 UmuD protein EYD11_24775 ENOG4105EPC oxidoreductase EYD11_24780 ENOG4108ZGB N-(5'-phosphoribosyl)anthranilate isomerase EYD11_24795 ENOG4105F2I Transposase EYD11_24800 ENOG4105F9F transposase EYD11_24855 ENOG4108X73 DNA- binding protein EYD11_24860 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) EYD11_24865 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) EYD11_24870 ENOG4105KK6 nuclease EYD11_24895 ENOG4106CQM replication EYD11_24950 ENOG410607W Transposase EYD11_25015 ENOG4105M0J Toxic component of a toxin-antitoxin (TA) module. A EYD11_25110 ENOG4105EQR Transposase IS116 IS110 IS902 EYD11_25130 ENOG4108R0M Aminoglycoside EYD11_25295 ENOG41073YN Protein of unknown function (DUF1380) EYD11_25390 ENOG41074AV Hok/gef family EYD11_25610 ENOG4107CBI conjugal transfer fertility inhibition protein EYD11_25640 ENOG4107AVE This protein is involved in the determination of copy number in gene replication. It binds to the repA promoter thus inhibiting the synthesis of the mRNA for the initiator protein repA (By similarity) EYD11_25895 ENOG41073YN Protein of unknown function (DUF1380) EYD11_25945 ENOG4105FEQ ParB domain protein nuclease EYD11_26040 ENOG4108UUM single-stranded DNA-binding protein EYD11_26060 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) EYD11_26155 ENOG4105CZX twitching motility protein EYD11_26220 ENOG4105K5T PilT protein EYD11_26235 ENOG4107QHF type ii secretion system protein e EYD11_26410 ENOG4106PHI plasmid recombination enzyme