locus-tag class description HVX45_00010 ENOG4105VZ1 Replication Protein HVX45_00025 ENOG4105ED4 portal protein HVX45_00115 ENOG410685N tail fiber protein HVX45_00120 ENOG4105UZW Tail fiber assembly protein HVX45_00170 ENOG4105ZTC transcriptional activator, Ogr delta HVX45_00175 ENOG4105C6N Formate acetyltransferase HVX45_00180 ENOG4105TMB Formate nitrite transporter HVX45_00185 ENOG4105DDY UPF0142 protein ycaO HVX45_00190 ENOG4107VMU Membrane HVX45_00210 ENOG4105CAV thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity) HVX45_00220 ENOG4108EQH DNA internalization-related competence protein ComEC Rec2 HVX45_00225 ENOG4105BZ1 (ABC) transporter HVX45_00235 ENOG4105T0Z Conserved Protein HVX45_00250 ENOG4107VR7 transferase activity, transferring phosphorus-containing groups HVX45_00255 ENOG4107S90 membrAne HVX45_00260 ENOG4106371 Methyltransferase HVX45_00270 ENOG4105DAH Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF (By similarity) HVX45_00280 ENOG4105DIT ErfK YbiS YcfS YnhG family protein HVX45_00285 ENOG4105EAQ (twin-arginine translocation) pathway signal HVX45_00290 ENOG4105C5X domain protein HVX45_00295 ENOG4105CGF Aromatic amino acid aminotransferase HVX45_00315 ENOG4105CD8 aminopeptidase N HVX45_00320 ENOG4105E2Y ABC, transporter HVX45_00325 ENOG4105EFS Binding-protein-dependent transport systems, inner membrane component HVX45_00335 ENOG4105GVF (ABC) transporter HVX45_00340 ENOG4108UZX fmn reductase HVX45_00350 ENOG4108T7E Contributes to the efficiency of the cell division process by stabilizing the polymeric form of the cell division protein FtsZ. Acts by promoting interactions between FtsZ protofilaments and suppressing the GTPase activity of FtsZ (By similarity) HVX45_00355 ENOG4105QVC MOSC domain-containing protein HVX45_00365 ENOG4105C5H ABC transporter HVX45_00370 ENOG4105F1S paraquat-inducible protein a HVX45_00375 ENOG4105DY2 Paraquat-inducible protein b HVX45_00380 ENOG4108Q2G (LipO)protein HVX45_00385 ENOG4105WFT During stationary phase, converts 70S ribosomes to an inactive dimeric form (100S ribosomes) (By similarity) HVX45_00395 ENOG4105DAN ATP-dependent protease HVX45_00415 ENOG4108RZ1 DNA transformation protein HVX45_00420 ENOG4105EM2 membrane HVX45_00425 ENOG410901E Membrane HVX45_00430 ENOG41088T4 Helicase IV HVX45_00445 ENOG4105K4P CoA-binding domain protein HVX45_00460 ENOG4105VSY K01512 acylphosphatase EC 3.6.1.7 HVX45_00465 ENOG4108Z0T Part of a sulfur-relay system (By similarity) HVX45_00470 ENOG4108MN8 Membrane HVX45_00485 ENOG4105E3S small subunit HVX45_00490 ENOG4105DPX Hydrogenase, large subunit HVX45_00495 ENOG4105X7T Ni Fe-hydrogenase, b-type cytochrome subunit HVX45_00500 ENOG4108USZ hydrogenase HVX45_00505 ENOG4108VXY Hydrogenase-1 operon protein HyaE HVX45_00510 ENOG4105MVP hydrogenase-1 operon protein HyaF HVX45_00515 ENOG4106RHG Yeca family HVX45_00520 ENOG4105E0U tyrosine-specific transport protein HVX45_00525 ENOG4105VVZ metal-binding protein HVX45_00530 ENOG41090A1 ferritin HVX45_00535 ENOG4105P23 (LipO)protein HVX45_00540 ENOG4108UEC Ferritin-like protein HVX45_00545 ENOG4105DMK Periplasmic binding protein LacI transcriptional regulator HVX45_00550 ENOG4105C2J ABC transporter HVX45_00555 ENOG4105CNN ABC, transporter HVX45_00560 ENOG4108K4C ec 3.1.3.12 HVX45_00570 ENOG4108VA4 Universal stress protein HVX45_00580 ENOG4106CIA Functions in complex with FlhD as a master transcriptional regulator that regulates transcription of several flagellar and non-flagellar operons by binding to their promoter region HVX45_00585 ENOG4107RD7 Flagellar Motor Protein, MotA HVX45_00590 ENOG4105ER2 Ompa motb domain protein HVX45_00595 ENOG4105CBS Chea signal transduction histidine kinase HVX45_00600 ENOG4108V3W Chemotaxis protein, CheW HVX45_00630 ENOG4105C8Q Methyl-accepting chemotaxis HVX45_00635 ENOG4105BZU Histidine kinase HVX45_00645 ENOG4108VYJ response regulator receiver protein HVX45_00670 ENOG4105MWK D-amino acid dehydrogenase, small subunit HVX45_00675 ENOG4105RQF LysR family Transcriptional regulator HVX45_00685 ENOG4105D6F Phosphatase HVX45_00690 ENOG4105XH3 HVX45_00700 ENOG4105XF5 Escherichia coli IMT2125 genomic chromosome, IMT2125 HVX45_00705 ENOG4108R86 Transcriptional regulator HVX45_00710 ENOG4105BZU Histidine kinase HVX45_00715 ENOG41064RH membrane protein YliF HVX45_00720 ENOG4107QZ7 Cellulose synthase catalytic subunit HVX45_00725 ENOG4107EEX Cellulose synthase regulator protein HVX45_00735 ENOG41066VF YeeE YedE family protein HVX45_00740 ENOG4108W9D (LipO)protein HVX45_00745 ENOG4105E5K Alpha-amylase HVX45_00750 ENOG4105YXP it directly binds FlhC, thus inhibiting the binding of the FlhC FlhD complex to class 2 promoters, resulting in decreased expression of class 2 flagellar operons. As a chaperone, effects FliD transition to the membrane by preventing its premature polymerization, and by directing it to the export apparatus (By similarity) HVX45_00755 ENOG4105MQ3 flagellar protein FliS HVX45_00760 ENOG4105DTS flagellar hook-associated HVX45_00770 ENOG4105DN4 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HVX45_00775 ENOG4108M9K flagella biosynthesis protein FliZ HVX45_00780 ENOG4105EAB amino acid AbC transporter HVX45_00790 ENOG4105E5Q amino acid AbC transporter HVX45_00795 ENOG4105CDA abc transporter atp-binding protein HVX45_00800 ENOG4105VJY transcriptional regulator HVX45_00805 ENOG4105XVG cytoplasmic protein HVX45_00810 ENOG4105WH1 Two component transcriptional regulator luxr family HVX45_00840 ENOG4107SVH Potassium channel protein HVX45_00845 ENOG4105C4M (Ubiquinol oxidase) subunit I HVX45_00850 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii HVX45_00865 ENOG4105BZU Histidine kinase HVX45_00870 ENOG4108SV3 Tmao reductase system periplasmic protein tort HVX45_00875 ENOG4106WF9 DNA-binding transcriptional regulator TorR HVX45_00880 ENOG4105CUW cytochrome C-TYPE protein HVX45_00885 ENOG4107QY8 reductase HVX45_00895 ENOG4105D00 flagellar biosynthetic protein flhB HVX45_00900 ENOG4105D7B Flagellar biosynthesis protein flha HVX45_00905 ENOG4105W13 flagellar protein HVX45_00915 ENOG4106ZCM YecM protein HVX45_00935 ENOG4105WJG Glutathione HVX45_00940 ENOG41081XQ Conserved Protein HVX45_00945 ENOG4105D3W isochorismatase HVX45_00955 ENOG4108TIT dATP pyrophosphohydrolase HVX45_00960 ENOG4105CDY transcriptional regulatory protein HVX45_00970 ENOG4107S01 Repressor protein MetJ HVX45_00990 ENOG4105KA4 The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity) HVX45_01000 ENOG4105FAV ABC, transporter HVX45_01010 ENOG4105NXV High-affinity zinc uptake system protein HVX45_01015 ENOG4105DR5 peptidase HVX45_01020 ENOG4105NWR lipid A biosynthesis (Kdo)2-(Lauroyl)-lipid IVA acyltransferase HVX45_01025 ENOG4105CA9 Pyruvate kinase HVX45_01030 ENOG4106KNT transcriptional regulator HVX45_01035 ENOG4105D8W glucose-6-phosphate 1-dehydrogenase HVX45_01040 ENOG4105C01 Dihydroxy-acid dehydratase HVX45_01045 ENOG4108UHU Aldolase HVX45_01050 ENOG4108HH9 Catalyzes two reactions the first one is the production of beta-formyl glycinamide ribonucleotide (GAR) from formate, ATP and beta GAR HVX45_01055 ENOG4105X2V dna damage-inducible protein HVX45_01065 ENOG4108Q2J Inner membrane protein YebE HVX45_01070 ENOG4105CUG Oligopeptidase b HVX45_01075 ENOG4105UMD exodeoxyribonuclease X HVX45_01080 ENOG4108YGA nitrilase cyanide hydratase and apolipoprotein n-acyltransferase HVX45_01085 ENOG4105MPK DNA polymerase III subunit theta HVX45_01090 ENOG4105FXM Copper resistance protein HVX45_01095 ENOG4108PNC copper resistance HVX45_01100 ENOG4105NKT exported protein HVX45_01105 ENOG4108R1E Serine threonine protein phosphatase 1 HVX45_01110 ENOG4105UVW uncharacterized protein yebW HVX45_01115 ENOG4105WT8 Protein of unknown function (DUF1480) HVX45_01125 ENOG4105DY2 Paraquat-inducible protein b HVX45_01130 ENOG4105H2K paraquat-inducible protein a HVX45_01135 ENOG4108ZGC gaf domain protein HVX45_01145 ENOG4105CN1 protease HVX45_01155 ENOG4105C0R drug resistance transporter emrb qaca subfamily HVX45_01160 ENOG4105J4Q Transcriptional regulator HVX45_01165 ENOG4105TIK HVX45_01175 ENOG4105Q3Y exported protein HVX45_01190 ENOG4105DHI Methyltransferase HVX45_01205 ENOG4105F3R pts system mannose fructose sorbose family iid HVX45_01210 ENOG4105ETZ PTS System HVX45_01215 ENOG4105DAS pts system HVX45_01220 ENOG4105EE5 Membrane protein terC HVX45_01225 ENOG4107XTP (EAL) domain protein HVX45_01230 ENOG4105EJQ L-serine dehydratase HVX45_01240 ENOG4105CRQ synthase (Component I) HVX45_01255 ENOG4105V2F Uncharacterized protein yoac HVX45_01260 ENOG4105M4H endoribonuclease L-psp HVX45_01275 ENOG4105DVT helicase HVX45_01280 ENOG41072GX Peptidase M22 Glycoprotease HVX45_01285 ENOG4105Y4Z Outer Membrane Lipoprotein HVX45_01290 ENOG4105CEY Amp-dependent synthetase and ligase HVX45_01295 ENOG4105ZIE Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides (By similarity) HVX45_01300 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein HVX45_01305 ENOG4108JA2 transcriptioN-repair coupling factor HVX45_01310 ENOG4105IQC Inner membrane protein YcfT HVX45_01315 ENOG4105D60 lipoprotein releasing system transmembrane protein HVX45_01320 ENOG4105CQU Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity) HVX45_01325 ENOG4105D60 lipoprotein releasing system transmembrane protein HVX45_01335 ENOG4105NDF NAD-dependent protein deacetylase which modulates the activities of several enzymes which are inactive in their acetylated form. May also have NAD-dependent lysine demalonylase and desuccinylase activity (By similarity) HVX45_01350 ENOG4107RUE extracellular solute-binding protein family 1 HVX45_01355 ENOG4105D38 putrescine abc transporter HVX45_01375 ENOG4105DSB aldose 1-epimerase HVX45_01390 ENOG4105VUT cytoplasmic protein HVX45_01395 ENOG4108RWI nicotinamidase HVX45_01400 ENOG4105HDK L-asparaginase HVX45_01410 ENOG4105D07 Signal peptide peptidase, SppA HVX45_01415 ENOG41069NU Nitroreductase HVX45_01425 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) HVX45_01435 ENOG4105F7F Chaperone HVX45_01445 ENOG4105D82 Glutamate dehydrogenase HVX45_01450 ENOG4105MTM Protein of unknown function (DUF1496) HVX45_01455 ENOG4105M6F mutator MutT protein HVX45_01460 ENOG4108T9J Cdp-alcohol phosphatidyltransferase HVX45_01465 ENOG4107RM6 sulfurtransferase HVX45_01470 ENOG4108VGW abc transporter atp-binding protein HVX45_01475 ENOG4105CXZ ABC transporter, permease HVX45_01480 ENOG4105VNH ABC transporter solute-binding protein HVX45_01485 ENOG4107ZN8 Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) HVX45_01490 ENOG4108N5C SNARE associated Golgi protein-related protein HVX45_01495 ENOG4108RSN SNARE associated Golgi HVX45_01500 ENOG4105CGK Exodeoxyribonuclease III HVX45_01530 ENOG4108SPG Periplasmic Protein HVX45_01540 ENOG4105DKD Incises the DNA at the 3' side of a lesion during nucleotide excision repair. Incises the DNA farther away from the lesion than UvrC. Not able to incise the 5' site of a lesion. When a lesion remains because UvrC is not able to induce the 3' incision, Cho incises the DNA. Then UvrC makes the 5' incision. The combined action of Cho and UvrC broadens the substrate range of nucleotide excision repair (By similarity) HVX45_01550 ENOG4105KKI DNA-binding transcriptional activator OsmE HVX45_01555 ENOG4105VZJ PTS System HVX45_01560 ENOG4105CK1 PTS System HVX45_01565 ENOG4105VCP PTS System HVX45_01570 ENOG4105EZV Transcriptional regulator HVX45_01575 ENOG4105F8D glycoside hydrolase family 4 HVX45_01585 ENOG4105CH6 catalase HVX45_01590 ENOG4105R8J Activates the cell division inhibited by chromosomal DNA over-replication (By similarity) HVX45_01595 ENOG4108ETY sodium dicarboxylate symporter HVX45_01600 ENOG4107K5X Membrane-bound metal-dependent hydrolase HVX45_01605 ENOG4107UW8 HAD-superfamily hydrolase subfamily IA variant 3 HVX45_01610 ENOG4107PN8 YfeABCD locus regulator HVX45_01620 ENOG4105P10 Uncharacterized protein ydiZ HVX45_01625 ENOG4105DE4 1-phosphofructokinase HVX45_01630 ENOG4108NE3 Salt-induced outer membrane protein HVX45_01645 ENOG4108UUX IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity) HVX45_01650 ENOG41082NX 50s ribosomal protein l35 HVX45_01735 ENOG4108C33 Resolvase HVX45_01745 ENOG4105UZW Tail fiber assembly protein HVX45_01750 ENOG4108X9F tail fiber protein HVX45_01830 ENOG4105ED4 portal protein HVX45_01900 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HVX45_01920 ENOG41080WI Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system (By similarity) HVX45_01925 ENOG4108QBX (LipO)protein HVX45_01945 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) HVX45_01955 ENOG4108HRN Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity) HVX45_01960 ENOG4105SUA Ydil protein HVX45_01970 ENOG4105IPI Membrane HVX45_01975 ENOG4105CQB FAD linked oxidase domain protein HVX45_01980 ENOG4105KA0 thioesterase Superfamily protein HVX45_01985 ENOG410671Z uncharacterized protein ydiH HVX45_01990 ENOG4108Z4V iron-sulfur cluster assembly HVX45_01995 ENOG4105DIW FeS assembly protein SUFB HVX45_02000 ENOG4105C3K feS assembly ATPase SufC HVX45_02005 ENOG4105JRK feS assembly protein SufD HVX45_02020 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein HVX45_02025 ENOG4105KMX major outer membrane lipoprotein HVX45_02030 ENOG4105CA9 Pyruvate kinase HVX45_02035 ENOG4105RFR Protein of unknown function (DUF2767) HVX45_02040 ENOG4108KTU conserved protein with FAD NAD(P)-binding domain HVX45_02045 ENOG4105N0V mono-oxygenase ydhR HVX45_02065 ENOG4108R6K riboflavin synthase, subunit alpha HVX45_02070 ENOG4105CV9 cyclopropane-fatty-acyl-phospholipid synthase HVX45_02075 ENOG4105CZQ inner membrane transport protein YdhC HVX45_02080 ENOG4105F52 Transcriptional regulator HVX45_02095 ENOG4105F27 Major Facilitator HVX45_02100 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) HVX45_02105 ENOG4105K4H Nlp p60 protein HVX45_02110 ENOG4105M2J Glutaredoxin HVX45_02115 ENOG4107QRT dEAD DEAH box helicase HVX45_02120 ENOG4105DH5 Responsible for the end-turnover of tRNA specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A). Also appears to be involved in tRNA biosynthesis (By similarity) HVX45_02125 ENOG4108UYE Lactoylglutathione lyase HVX45_02130 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HVX45_02135 ENOG4108WUH Transcriptional regulator, TetR family HVX45_02140 ENOG4105XZD Fe-S protein HVX45_02145 ENOG4107RGM aldo keto reductase HVX45_02150 ENOG4108Z7T Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) HVX45_02155 ENOG4105DSW Fusaric acid resistance protein HVX45_02160 ENOG4105Y49 secretion protein, HlyD family HVX45_02175 ENOG4108XTF Outer Membrane Lipoprotein HVX45_02185 ENOG410642K Lysozyme inhibitor HVX45_02200 ENOG4107XGF functions in a salvage pathway. Uses pyridoxamine (By similarity) HVX45_02205 ENOG4108K3A Glutathione S-transferase HVX45_02210 ENOG4105DUX Transporter HVX45_02215 ENOG4105CSM endonuclease III HVX45_02225 ENOG4108UQQ Electron transport complex HVX45_02250 ENOG4105M9B inner membrane protein ydgK HVX45_02255 ENOG4105QZ5 OriC-binding nucleoid-associated protein HVX45_02260 ENOG4106C6R beta-lactam resistance protein HVX45_02265 ENOG4105D9R oxidoreductase HVX45_02275 ENOG4105C87 Aminotransferase class I and II HVX45_02280 ENOG4106J39 exported protein HVX45_02285 ENOG4105EIP mannose-6-phosphate isomerase HVX45_02290 ENOG4107GFK fumarate HVX45_02295 ENOG4105C9Q fumarate hydratase class II HVX45_02305 ENOG4105JJR Histidine kinase HVX45_02310 ENOG4107EXC regulatoR HVX45_02315 ENOG4105RA2 Membrane HVX45_02325 ENOG4105D5Q Arginine ornithine antiporter HVX45_02330 ENOG4105C5D exported protein HVX45_02335 ENOG4108IIE The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) HVX45_02340 ENOG4105C15 The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane (By similarity) HVX45_02345 ENOG4105BZU Histidine kinase HVX45_02350 ENOG4105CVW peptidase s1 and s6 chymotrypsin hap HVX45_02365 ENOG4105D94 Major Facilitator Superfamily HVX45_02370 ENOG4106NZI LysR family Transcriptional regulator HVX45_02375 ENOG4105DAG ROK family HVX45_02380 ENOG4105EWW Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) HVX45_02385 ENOG4105CMQ Chloride channel HVX45_02390 ENOG4108IJ8 ABC transporter HVX45_02395 ENOG4105E90 ABC transporter HVX45_02400 ENOG4107SI7 Substrate-binding region of abc-type glycine betaine transport system HVX45_02405 ENOG4108U0I binding-protein-dependent transport systems inner membrane Component HVX45_02410 ENOG4105R71 cytoplasmic protein HVX45_02415 ENOG4108T9Y Inner membrane protein ydcZ HVX45_02420 ENOG4108Z7F N-acetyltransferase HVX45_02425 ENOG4105CJH Alcohol dehydrogenase zinc-binding domain protein HVX45_02430 ENOG4108WYP Transcriptional regulator HVX45_02435 ENOG4105CHB tonB-dependent Receptor HVX45_02440 ENOG4108NS2 receptor HVX45_02445 ENOG4105C85 amino acid HVX45_02450 ENOG4108N27 Glutathione S-transferase HVX45_02460 ENOG410600T transposase HVX45_02525 ENOG4105JAB phenazine biosynthesis protein, phzf family HVX45_02530 ENOG4105DIA mandelate racemase muconate lactonizing HVX45_02545 ENOG4108MEJ flavin reductase domain protein HVX45_02550 ENOG4108MUX N-hydroxyarylamine O-acetyltransferase HVX45_02555 ENOG4107HP6 Transcriptional regulator HVX45_02560 ENOG4105DTQ mandelate racemase muconate lactonizing HVX45_02565 ENOG4105NN7 muconolactone delta-isomerase HVX45_02570 ENOG410626B catechol 1,2-dioxygenase HVX45_02605 ENOG4105RPH Inner membrane protein YddG HVX45_02615 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein HVX45_02620 ENOG4108MG3 formate dehydrogenase HVX45_02625 ENOG41084S7 Plasmid maintenance system antidote protein HVX45_02635 ENOG4105DQ4 alcohol dehydrogenase HVX45_02645 ENOG4107AV5 Although this protein associates with the 30S subunit of the ribosome it is not considered to be a bona fide ribosomal protein HVX45_02650 ENOG4105TPS biofilm-dependent modulation protein HVX45_02655 ENOG4108Z9K Osmotically inducible protein HVX45_02665 ENOG4105DDW LysR family Transcriptional regulator HVX45_02670 ENOG4105RM9 Protocatechuate 3,4-dioxygenase alpha HVX45_02675 ENOG4105EU7 Protocatechuate 3,4-dioxygenase, beta HVX45_02680 ENOG4105E32 cytoplasmic protein HVX45_02690 ENOG4105Z2P Protein of unknown function (DUF465) HVX45_02695 ENOG4108Z9I -acetyltransferase HVX45_02700 ENOG4107WE3 acetyltransferase YdcK HVX45_02705 ENOG41088CC tellurite resistance protein tehB HVX45_02710 ENOG4108KKZ (LipO)protein HVX45_02715 ENOG4105CFP Peptidase U32 HVX45_02725 ENOG4105RR0 Protein of unknown function (DUF2554) HVX45_02730 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HVX45_02735 ENOG4107TYH extracellular solute-binding protein family 1 HVX45_02740 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HVX45_02745 ENOG4105D81 ABC transporter, permease HVX45_02750 ENOG4105NRK Binding-protein-dependent transport systems, inner membrane component HVX45_02765 ENOG410654E Membrane HVX45_02770 ENOG4105KBG Protein of unknown function (DUF1161) HVX45_02780 ENOG4108MK9 spermidine N(1)-acetyltransferase HVX45_02795 ENOG4105CXK mandelate racemase muconate lactonizing HVX45_02800 ENOG4105CPQ Dehydrogenase HVX45_02805 ENOG4105GQU Trap dicarboxylate transporter, dctp subunit HVX45_02815 ENOG4105CG6 trap dicarboxylate transporter dctm subunit HVX45_02820 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit HVX45_02825 ENOG4105CG6 trap dicarboxylate transporter dctm subunit HVX45_02835 ENOG4105DEI Mannitol dehydrogenase HVX45_02840 ENOG41061EV selenium-binding protein YdfZ HVX45_02845 ENOG4107XBN GntR Family Transcriptional Regulator HVX45_02850 ENOG4105EMU Dehydrogenase HVX45_02855 ENOG4105DGW oligopeptidase A HVX45_02860 ENOG4108WTK competence damage-inducible protein HVX45_02865 ENOG4108YDI single-species biofilm formation on inanimate substrate HVX45_02870 ENOG4105FSR swimming returnes to normal when residues 206-207 are both mutated to Ala. Overexpression also leads to a reduction in flagellar abundance and a 20-fold increase in c-di- GMP levels in vivo. Required for aminoglycoside-mediated induction of biofilm formation, it also plays a lesser role in biofilm production in response to other classes of translation inhibitors. The c-di-GMP produced by this enzyme up-regulates poly-GlcNAc production as well as the biofilm synthesis protein PgaD, although c-di-GMP is probably not the main inducing principle. Cyclic-di- GMP is a second messenger which controls cell surface-associated traits in bacteria HVX45_02875 ENOG4105E5W Transporter HVX45_02880 ENOG4108594 Permease of the drug metabolite transporter HVX45_02885 ENOG4106DNR multiple antibiotic resistance protein HVX45_02890 ENOG4108XW0 May be a transcriptional activator of genes involved in the multiple antibiotic resistance (Mar) phenotype. It can also activate genes such as sodA, zwf and micF HVX45_02895 ENOG4108T3F Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes HVX45_02910 ENOG4105EGI Transcriptional regulator HVX45_02915 ENOG4105C26 Dehydrogenase HVX45_02920 ENOG4105CSV Glutaminase HVX45_02925 ENOG4105M0C cytoplasmic protein HVX45_02930 ENOG4105BZU Histidine kinase HVX45_02940 ENOG4105FFC UPF0187 protein HVX45_02950 ENOG4105D7V transposase HVX45_02960 ENOG4105K34 Involved in the degradation of phospho-AI-2, thereby terminating induction of the lsr operon and closing the AI-2 signaling cycle. Catalyzes the cleavage of phosphorylated 4,5- dihydroxy-2,3-pentanedione (P-DPD) to 2-phosphoglycolic acid (PG) and another three-carbon compound HVX45_02985 ENOG4105C2J ABC transporter HVX45_02995 ENOG4108EMV Catalyzes the phosphorylation of autoinducer 2 (AI-2) to phospho-AI-2, which subsequently inactivates the transcriptional regulator LsrR and leads to the transcription of the lsr operon. Phosphorylates the ring-open form of 4,5-dihydroxy-2,3- pentanedione (DPD), which is the precursor to all AI-2 signaling molecules, at the C5 position (By similarity) HVX45_03005 ENOG4108R6W Transcriptional regulator, ARAC family HVX45_03010 ENOG4106PHM regulatory protein HVX45_03030 ENOG4105PE1 Receptor HVX45_03035 ENOG4107RAN Peptidase, M16 HVX45_03040 ENOG4105CVK Glutamate decarboxylase HVX45_03045 ENOG4105E5D amino acid HVX45_03050 ENOG4105F32 YngK protein HVX45_03055 ENOG4105BZU Histidine kinase HVX45_03060 ENOG4105BZU Histidine kinase HVX45_03075 ENOG4105CPW cytochrome b561 HVX45_03080 ENOG4105C17 glyceraldehyde-3-phosphate dehydrogenase HVX45_03085 ENOG4107DB1 DUF218 domain HVX45_03095 ENOG4105CQ7 ATP-dependent helicase HVX45_03105 ENOG41077RS Phosphatase HVX45_03110 ENOG4105E8V Alpha Beta Hydrolase Fold protein HVX45_03115 ENOG4108HPI phosphatidate Cytidylyltransferase HVX45_03120 ENOG4108UMZ Cdp-alcohol phosphatidyltransferase HVX45_03130 ENOG4107S5I aldo keto reductase HVX45_03135 ENOG4108Z0R Transferase HVX45_03140 ENOG4105V9J phenylacetic acid degradation operon negative regulatory protein HVX45_03145 ENOG4105DZS Phenylacetate-CoA ligase HVX45_03150 ENOG4105CHU acetyl-coa acetyltransferase HVX45_03155 ENOG4108ZJI phenylacetic acid degradation protein HVX45_03160 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase HVX45_03165 ENOG4108UKI Enoyl-CoA hydratase HVX45_03170 ENOG4105E39 Enoyl-CoA hydratase HVX45_03175 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) HVX45_03180 ENOG4108ZA2 phenylacetate-CoA oxygenase PaaJ subunit HVX45_03185 ENOG4105D9S phenylacetate-CoA oxygenase PaaI subunit HVX45_03190 ENOG4105N76 Phenylacetate-CoA oxygenase, subunit HVX45_03195 ENOG4105CRS phenylacetate-CoA oxygenase PaaG subunit HVX45_03200 ENOG4105DXM phenylacetic acid degradation protein HVX45_03205 ENOG4105F11 amine oxidase HVX45_03210 ENOG4105C26 Dehydrogenase HVX45_03215 ENOG4108WFR AraC Family Transcriptional Regulator HVX45_03225 ENOG4105WXT Conserved Protein HVX45_03230 ENOG410689M (LipO)protein HVX45_03235 ENOG4107H52 Dicarboxylate transport HVX45_03240 ENOG4105C5I Dehydrogenase HVX45_03245 ENOG41090X5 Heat shock protein hslJ HVX45_03250 ENOG4105IKK cytoplasmic protein HVX45_03260 ENOG4105D95 Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin (By similarity) HVX45_03265 ENOG4105FCK Membrane HVX45_03270 ENOG4108RW8 Universal stress protein F HVX45_03280 ENOG4105C1J atp-dependent rna helicase HVX45_03295 ENOG4105BZU Histidine kinase HVX45_03300 ENOG4108UWZ 4-Carboxymuconolactone decarboxylase HVX45_03305 ENOG4105F2Z 3-oxoadipate enol-lactonase HVX45_03310 ENOG4107RAW 3-carboxy-cis-cis-muconate cycloisomerase HVX45_03315 ENOG4105CHU acetyl-coa acetyltransferase HVX45_03320 ENOG4107QNJ CoA-transferase subunit B HVX45_03330 ENOG4107HP6 Transcriptional regulator HVX45_03335 ENOG4108DG9 Smr protein MutS2 HVX45_03340 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) HVX45_03345 ENOG4105DS0 Transcriptional regulator, Crp Fnr family HVX45_03350 ENOG4105Q9Y Universal stress protein HVX45_03355 ENOG4105S5I Membrane HVX45_03360 ENOG4105D64 Mechanosensitive ion channel HVX45_03365 ENOG4107QSI ABC, transporter HVX45_03370 ENOG4105KXI murein peptide amidase A HVX45_03375 ENOG4107S8C mandelate racemase muconate lactonizing HVX45_03380 ENOG4108V1J Has antioxidant activity. Could remove peroxides or H(2)O(2) (By similarity) HVX45_03385 ENOG4108JU8 Transcriptional regulator HVX45_03395 ENOG4105CM6 amino acid regulated cytosolic protein HVX45_03400 ENOG4105K8Z Phage shock protein HVX45_03405 ENOG4105NNG Peripheral inner membrane phage-shock protein HVX45_03410 ENOG4105FM1 phage shock protein C HVX45_03415 ENOG4105YYT phage shock protein B HVX45_03420 ENOG41087YS Phage shock protein A HVX45_03425 ENOG4105E51 psp operon transcriptional activator HVX45_03430 ENOG4108HIY periplasmic HVX45_03435 ENOG4108I5W peptide transport system, permease protein HVX45_03440 ENOG4108EU3 peptide transport system, permease HVX45_03445 ENOG4108JQ3 Peptide ABC transporter ATP-binding protein HVX45_03450 ENOG4108JQ2 peptide transport system atp-binding protein HVX45_03455 ENOG4105CSJ Enoyl- acyl-carrier-protein reductase NADH HVX45_03460 ENOG4105Q4T oxidoreductase HVX45_03470 ENOG4105BZU Histidine kinase HVX45_03480 ENOG4105N2W Transcriptional regulator HVX45_03490 ENOG4108ZJT translation initiation factor, Sui1 HVX45_03500 ENOG4105CFV Tetratricopeptide repeat protein HVX45_03505 ENOG4105Q4A inner membrane protein yciS HVX45_03510 ENOG4105EYK Phosphatidylglycerophosphatase B HVX45_03520 ENOG4107QM5 aconitate hydratase HVX45_03535 ENOG4107R11 Transcriptional regulator HVX45_03540 ENOG4105C73 Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity) HVX45_03545 ENOG4105RKX Protein of unknown function (DUF2498) HVX45_03550 ENOG4105ERU peptidase HVX45_03555 ENOG4105UBK short-chain dehydrogenase reductase HVX45_03560 ENOG41068B1 Cob-I-yrinic acid a,c-diamide adenosyltransferase HVX45_03565 ENOG4105FE9 pseudouridine synthase HVX45_03570 ENOG4105EG3 transmembrane signal peptide protein HVX45_03575 ENOG4107RTD sua5 ycio yrdc ywlc family protein HVX45_03580 ENOG4105DB7 PHP domain protein HVX45_03590 ENOG4105CRQ synthase (Component I) HVX45_03595 ENOG4108EFP Anthranilate synthase component II HVX45_03600 ENOG4105DK0 Indole-3-glycerol phosphate synthase HVX45_03615 ENOG4105EIF outer membrane protein W HVX45_03620 ENOG4105PI0 Ferredoxin HVX45_03635 ENOG4105NAU thioesterase Superfamily protein HVX45_03640 ENOG410822N TonB family HVX45_03645 ENOG4105K9H YciI-like protein HVX45_03655 ENOG4105D7V transposase HVX45_03670 ENOG4105EYW Ion transport protein HVX45_03675 ENOG4108JQ7 (ABC) transporter HVX45_03680 ENOG4105C3U ABC transporter HVX45_03685 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HVX45_03690 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HVX45_03695 ENOG4107QSI ABC, transporter HVX45_03700 ENOG4105EZI multiple antibiotic resistance (MarC)-related protein HVX45_03705 ENOG4105C0A alcohol dehydrogenase HVX45_03715 ENOG4107104 thymidine kinase HVX45_03725 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase HVX45_03730 ENOG4105I93 response regulator HVX45_03735 ENOG4105D78 K07001 NTE family protein HVX45_03745 ENOG4105CIY formyltetrahydrofolate deformylase HVX45_03790 ENOG4107VBM 3-beta hydroxysteroid dehydrogenase isomerase HVX45_03795 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) HVX45_03800 ENOG41076YT nitrate reductase, gamma subunit HVX45_03805 ENOG4105R3A Nitrate reductase HVX45_03810 ENOG4108IUE nitrate reductase beta subunit HVX45_03815 ENOG4105CRU nitrate reductase, alpha subunit HVX45_03820 ENOG4105DQQ Major facilitator superfamily MFS_1 HVX45_03825 ENOG4105BZU Histidine kinase HVX45_03830 ENOG4105WH1 Two component transcriptional regulator luxr family HVX45_03835 ENOG4105ID0 Putative invasin HVX45_03840 ENOG41090EX DsrE family HVX45_03845 ENOG4108NH8 Cation transport protein HVX45_03850 ENOG4105WS7 Cation transport regulator HVX45_03855 ENOG4105EWV Sodium calcium exchanger membrane region HVX45_03870 ENOG41063JG Transcriptional regulator HVX45_03875 ENOG4105EQY Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity) HVX45_03900 ENOG4105C5T Phosphoribosyl pyrophosphate synthase HVX45_03905 ENOG4105CHH sulfate transporter HVX45_03910 ENOG4105MGX transcription activated by CRP (cyclic AMP receptor protein), a global transcription factor involved in regulation of metabolism in enteric bacteria HVX45_03920 ENOG4105C3G gtp-binding protein HVX45_03925 ENOG4105E53 ec 3.2.1.28 HVX45_03935 ENOG4108T7K Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Increasing levels of c-di-GMP lead to decreased motility (By similarity) HVX45_03945 ENOG4105EBE Peptidase U61, LD-carboxypeptidase A HVX45_03955 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) HVX45_03965 ENOG4105ED1 spovr family HVX45_03980 ENOG410635M Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein (By similarity) HVX45_03985 ENOG4105TNG K13735 adhesin invasin HVX45_03995 ENOG4105FBJ fumarylacetoacetate (faa) hydrolase HVX45_04010 ENOG4107QMS site-determining protein HVX45_04020 ENOG4105EFJ Part of the ABC transporter complex NikABCDE involved in nickel import. Responsible for energy coupling to the transport system (By similarity) HVX45_04025 ENOG4106665 Part of the ABC transporter complex NikABCDE involved in nickel import. Responsible for energy coupling to the transport system (By similarity) HVX45_04030 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HVX45_04040 ENOG4107RNA Nickel ABC transporter, periplasmic nickel-binding protein HVX45_04060 ENOG41066UD Inhibits activity of g-type lysozyme, which confers increased lysozyme tolerance to the bacterium HVX45_04075 ENOG4105CDY transcriptional regulatory protein HVX45_04085 ENOG4105TNG K13735 adhesin invasin HVX45_04095 ENOG4105JAB phenazine biosynthesis protein, phzf family HVX45_04100 ENOG4108I1J Integrase HVX45_04105 ENOG4108HMX isocitrate dehydrogenase (NADP) HVX45_04130 ENOG4107QTF adenylosuccinate lyase HVX45_04135 ENOG4105XJC Two component transcriptional regulator (Winged helix family HVX45_04140 ENOG4105IFJ Histidine kinase HVX45_04145 ENOG4105EZE Cupin 4 family protein HVX45_04150 ENOG4105CV8 reductase HVX45_04155 ENOG4105GNX MltA-interacting MipA family protein HVX45_04160 ENOG4105CYN Serine protein kinase HVX45_04170 ENOG4106KTS Inner membrane protein yeaI HVX45_04175 ENOG4108KHP Diguanylate cyclase HVX45_04180 ENOG4108KXH Ybak prolyl-tRNA synthetase associated HVX45_04195 ENOG4105DJ2 Major Facilitator Superfamily HVX45_04200 ENOG4105K78 MarR family Transcriptional regulator HVX45_04205 ENOG4105UCG Domain of unknown function (DUF333) HVX45_04210 ENOG410620I Diguanylate cyclase HVX45_04215 ENOG4106G4W HVX45_04225 ENOG4105Y3U Transglycosylase-associated protein HVX45_04235 ENOG4107MBR 17 kDa surface antigen HVX45_04240 ENOG4105CEP NADH dehydrogenase HVX45_04255 ENOG4108RUM thiamine kinase HVX45_04260 ENOG4108WEF Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b) (By similarity) HVX45_04265 ENOG41090DQ Lipoprotein HVX45_04270 ENOG4105K59 histidine triad (HIT) protein HVX45_04275 ENOG4105CI1 PTS System HVX45_04280 ENOG4105F8V Hydrolase, tatD family HVX45_04285 ENOG4107QRG dna polymerase iii HVX45_04295 ENOG4105HHA aminodeoxychorismate lyase HVX45_04300 ENOG4105YAZ 4-amino-4-deoxychorismate lyase HVX45_04305 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) HVX45_04310 ENOG4105VNB Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity) HVX45_04315 ENOG4105CHR reductase HVX45_04320 ENOG4105CJF Malonyl coA-acyl carrier protein transacylase HVX45_04325 ENOG4105CCZ Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity) HVX45_04335 ENOG4105VGS 50s ribosomal protein l32 HVX45_04340 ENOG4105FCQ metal-binding, possibly nucleic acid-binding protein HVX45_04345 ENOG4108UHJ MAF-like protein HVX45_04350 ENOG4105EI2 Pseudouridine synthase HVX45_04355 ENOG4107QQB Ribonuclease E HVX45_04360 ENOG4105DTJ flagellar hook-associated protein HVX45_04365 ENOG4105E1Q flagellar hook-associated protein HVX45_04370 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj HVX45_04385 ENOG4105CGA flagellar basal-body rod protein FlgG HVX45_04390 ENOG4108KPB Flagellar basal-body rod protein FlgF HVX45_04395 ENOG4105BZE flagellar hook protein, FlgE HVX45_04400 ENOG4105W00 Flagellar hook capping protein HVX45_04405 ENOG4108ZC9 flagellar basal-body rod protein flgc HVX45_04410 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) HVX45_04415 ENOG4105CKS Flagella basal body P-ring formation protein flgA HVX45_04420 ENOG4105M9M anti-sigma28 factor FlgM HVX45_04425 ENOG4105QVD Flagella synthesis protein FlgN HVX45_04430 ENOG4105CJR Integral membrane protein (MviN HVX45_04435 ENOG4105EP9 oxidoreductase HVX45_04445 ENOG4105D9U N-acetyltransferase HVX45_04455 ENOG4105F3T (LipO)protein HVX45_04465 ENOG4105MEA DNA damage-inducible protein i HVX45_04470 ENOG4105PVA Biofilm formation regulatory protein BssS HVX45_04480 ENOG4105DS1 cytochrome b561 HVX45_04485 ENOG4108YYC ycei family HVX45_04495 ENOG4105D1S lipid A biosynthesis HVX45_04505 ENOG4108W47 Acidic protein msyB HVX45_04510 ENOG4105NAC (LipO)protein HVX45_04515 ENOG4105C3A Involved in the biosynthesis of osmoregulated periplasmic glucans (OPGs) (By similarity) HVX45_04525 ENOG4105EIK Necessary for the succinyl substitution of periplasmic glucans. Could catalyze the transfer of succinyl residues from the cytoplasmic side of the membrane to the nascent glucan backbones on the periplasmic side of the membrane (By similarity) HVX45_04530 ENOG4107RZC phospholipase d HVX45_04545 ENOG4105RK8 Plays a role in the extracellular assembly of CsgA into thin aggregative fimbriae (Tafi) fibers. Assembly may also require CsgE. Tafi are thought to be assembled via an extracellular nucleation-precipitation (ENP) pathway, and possibly also via an intracellular non-CsgC-dependent pathway (By similarity) HVX45_04550 ENOG4105G76 Curli are coiled surface structures that assemble preferentially at growth temperatures below 37 degrees Celsius. Curli can bind to fibronectin HVX45_04555 ENOG4108U0V Curli are coiled surface structures that assemble preferentially at growth temperatures below 37 degrees Celsius. Curli can bind to fibronectin. The minor subunit is the nucleation component of curlin monomers HVX45_04560 ENOG41086KC Transcriptional regulator HVX45_04565 ENOG4108XDW curli assembly protein CsgE HVX45_04570 ENOG4108WYR Curli production assembly transport component, CsgF HVX45_04575 ENOG4105P8Q Curli production assembly transport component CsgG HVX45_04580 ENOG4108UQ5 membrane protein YcdZ HVX45_04585 ENOG4107XHZ cytoplasmic chaperone TorD family protein HVX45_04605 ENOG4105CRK lysyL-tRNA synthetase HVX45_04610 ENOG4105DUX Transporter HVX45_04615 ENOG4105CXN decarboxylase HVX45_04620 ENOG4105D5Q Arginine ornithine antiporter HVX45_04625 ENOG4108M3R transcriptional activator CadC HVX45_04630 ENOG4105BZU Histidine kinase HVX45_04635 ENOG4108TUY outer membrane protein PgaA HVX45_04640 ENOG4107BJW polysaccharide deacetylase HVX45_04645 ENOG4105CND Glycosyl transferase, family 2 HVX45_04655 ENOG4105D5M phosphate starvation-inducible protein HVX45_04660 ENOG4105DBE peroxidase HVX45_04665 ENOG410650H (LipO)protein HVX45_04675 ENOG4105CK7 Sodium proline symporter HVX45_04685 ENOG4105C26 Dehydrogenase HVX45_04690 ENOG4105NWR lipid A biosynthesis (Kdo)2-(Lauroyl)-lipid IVA acyltransferase HVX45_04695 ENOG4108MJ5 VirK protein HVX45_04700 ENOG4107R5M Catalyzes the transfer of a N-acetyl-glucosamine moiety to 1D-myo-inositol 3-phosphate to produce 1D-myo-inositol 2- acetamido-2-deoxy-glucopyranoside 3-phosphate in the mycothiol biosynthesis pathway (By similarity) HVX45_04705 ENOG4107BJW polysaccharide deacetylase HVX45_04710 ENOG4105CQ3 Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity) HVX45_04715 ENOG4105KT5 UmuD protein HVX45_04725 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) HVX45_04730 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) HVX45_04735 ENOG41090PJ Flagellar assembly protein HVX45_04740 ENOG4108JIR Flagellum-specific ATP synthase HVX45_04745 ENOG4105GSA Flagellar export protein flij HVX45_04750 ENOG4105WF4 Flagellar hook-length control protein HVX45_04755 ENOG4107ZI8 flagellar basal body-associated protein flil HVX45_04760 ENOG4105D24 FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) HVX45_04765 ENOG4105DD5 Flagellar motor switch protein HVX45_04770 ENOG4105K0P flagellar biosynthesis protein HVX45_04775 ENOG4105CN7 Flagellar biosynthetic protein FliP HVX45_04780 ENOG4105VS8 Flagellar biosynthetic protein fliq HVX45_04785 ENOG4105D19 Role in flagellar biosynthesis (By similarity) HVX45_04790 ENOG4107TKS colanic acid capsular biosynthesis activation protein A HVX45_04800 ENOG4105YX3 cellular response to acidity HVX45_04815 ENOG4105VNZ cytoplasmic protein HVX45_04820 ENOG4105CKW Inner membrane protein yedI HVX45_04825 ENOG4105FDR Membrane HVX45_04830 ENOG41090BB DNA mismatch endonuclease (vsr) HVX45_04835 ENOG4105EST Metal Dependent Phosphohydrolase HVX45_04840 ENOG4105Y0K Inner membrane protein YedR HVX45_04845 ENOG4105ZIT Porin Gram-negative type HVX45_04855 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) HVX45_04880 ENOG4107R11 Transcriptional regulator HVX45_04925 ENOG4105GMB type VI secretion system effector, hcp1 family HVX45_04950 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit HVX45_05000 ENOG4108WC9 type VI secretion system effector, hcp1 family HVX45_05005 ENOG4105CS6 Rhs element vgr protein HVX45_05015 ENOG4107TV1 YD repeat protein HVX45_05025 ENOG410600T transposase HVX45_05045 ENOG4105FYV Amp nucleosidase HVX45_05050 ENOG4105CSH Transporter HVX45_05060 ENOG4105UQX Mate efflux family protein HVX45_05085 ENOG4105KNY Microcompartments protein HVX45_05090 ENOG4105KNY Microcompartments protein HVX45_05095 ENOG4105KNY Microcompartments protein HVX45_05100 ENOG4105C0A alcohol dehydrogenase HVX45_05110 ENOG4105C0A alcohol dehydrogenase HVX45_05115 ENOG4105C6N Formate acetyltransferase HVX45_05120 ENOG4105F1A Pyruvate formate-lyase HVX45_05125 ENOG4105KNY Microcompartments protein HVX45_05130 ENOG4108VPX Involved in 1,2-propanediol (1,2-PD) degradation by catalyzing the conversion of propanoyl-CoA to propanoyl-phosphate (By similarity) HVX45_05150 ENOG4108PXI ErfK YbiS YcfS YnhG HVX45_05155 ENOG4108P62 biosynthesis protein (CbiG) HVX45_05160 ENOG4107XVH Transcriptional regulator HVX45_05165 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) HVX45_05170 ENOG4105KNY Microcompartments protein HVX45_05175 ENOG4105EHR propanediol utilization protein pduB HVX45_05180 ENOG4105DMB glycerol dehydratase HVX45_05185 ENOG4105YCI dehydratase medium subunit HVX45_05190 ENOG4108ZFT Dehydratase small subunit HVX45_05195 ENOG41084PW diol glycerol dehydratase reactivating factor large subunit HVX45_05205 ENOG4105KNY Microcompartments protein HVX45_05225 ENOG4105WVM ethanolamine utilization protein EutN carboxysome structural protein Ccml HVX45_05235 ENOG4108EKI Dehydrogenase HVX45_05245 ENOG4107QTR Required for nitrogen fixation. May be part of a membrane complex functioning as an intermediate in the electron transport to nitrogenase (By similarity) HVX45_05255 ENOG4105M3W utilization protein HVX45_05260 ENOG4105KTW ethanolamine utilization protein HVX45_05275 ENOG4105DR8 Membrane HVX45_05285 ENOG4105CJB Exodeoxyribonuclease I HVX45_05295 ENOG4105CUC YeeE YedE family protein HVX45_05300 ENOG4105CUB amino acid HVX45_05310 ENOG4105EQ1 Transcriptional regulator HVX45_05315 ENOG4107SRH Nad-dependent epimerase dehydratase HVX45_05320 ENOG4105KRQ Addiction module toxin, Txe YoeB family HVX45_05325 ENOG4105VTW prevent-host-death family HVX45_05340 ENOG4105CEK Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity) HVX45_05350 ENOG4105ECC imidazole-glycerol-phosphate dehydratase HVX45_05355 ENOG4108UJE IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity) HVX45_05385 ENOG4105C7Q Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity) HVX45_05400 ENOG4107QPH glycogen) synthase HVX45_05415 ENOG4108MX3 Polysaccharide Biosynthesis Protein HVX45_05420 ENOG4108URP Dtdp-4-dehydrorhamnose 3,5-epimerase HVX45_05425 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) HVX45_05430 ENOG4105DBZ Dtdp-4-dehydrorhamnose reductase HVX45_05435 ENOG4105C1B dTDP-glucose 4-6-dehydratase HVX45_05440 ENOG4105C3Y UTP-glucose-1-phosphate uridylyltransferase HVX45_05445 ENOG4105DMT epimerase dehydratase HVX45_05450 ENOG4105G1A colanic acid biosynthesis protein HVX45_05455 ENOG4107T8Q Glycosyl transferase (Group 1 HVX45_05460 ENOG4105C74 pyruvyl transferase HVX45_05465 ENOG4105PSV Polysaccharide Biosynthesis Protein HVX45_05470 ENOG4105D3Q Sugar transferase HVX45_05475 ENOG4107QKV phosphomannomutase HVX45_05480 ENOG4105CJT Mannose-1-phosphate guanylyltransferase HVX45_05485 ENOG4106CD9 glycosyl transferase group 1 HVX45_05490 ENOG4105FGF GDP-mannose mannosyl hydrolase HVX45_05495 ENOG4105C30 Nad-dependent epimerase dehydratase HVX45_05500 ENOG4105C0K Gdp-mannose 4,6-dehydratase HVX45_05505 ENOG4108Z90 colanic acid biosynthesis acetyltransferase wcaF HVX45_05510 ENOG4105ECJ Glycosyl Transferase HVX45_05515 ENOG4108NYJ Colanic acid HVX45_05520 ENOG4107RXY Glycosyl transferase HVX45_05525 ENOG41068PY Colanic acid biosynthesis acetyltransferase wcaB HVX45_05530 ENOG41090RK glycosyl transferase HVX45_05535 ENOG4105D75 Capsular exopolysaccharide family HVX45_05540 ENOG4105KJF protein tyrosine phosphatase HVX45_05545 ENOG4105DAY polysaccharide export protein HVX45_05555 ENOG4105EE5 Membrane protein terC HVX45_05560 ENOG4105EQR Transposase IS116 IS110 IS902 HVX45_05575 ENOG4108GAE asmA family HVX45_05590 ENOG4105BZU Histidine kinase HVX45_05595 ENOG4105D03 DNA-3-methyladenine glycosylase II HVX45_05600 ENOG4105R8A Heat shock protein HVX45_05605 ENOG4106E1W protein with protein kinase and helix-hairpin-helix DNA-binding HVX45_05610 ENOG4105ZD5 Uncharacterized protein conserved in bacteria (DUF2314) HVX45_05615 ENOG4105UM3 Inherit from NOG: serine threonine phosphoprotein phosphatase HVX45_05620 ENOG4108M24 von Willebrand factor, type A HVX45_05655 ENOG4105EB3 Histidine kinase HVX45_05660 ENOG4105E3W Two component transcriptional regulator (Winged helix family HVX45_05665 ENOG4105KWI UPF0339 protein HVX45_05670 ENOG4105X54 addiction module antidote protein HVX45_05680 ENOG4105CFP Peptidase U32 HVX45_05690 ENOG4107UW8 HAD-superfamily hydrolase subfamily IA variant 3 HVX45_05695 ENOG4105IE8 Alpha-ketoglutarate permease HVX45_05700 ENOG4105CMG Carbohydrate kinase HVX45_05705 ENOG4105DEI Mannitol dehydrogenase HVX45_05725 ENOG4105EF1 ribulokinase HVX45_05730 ENOG4105IE8 Alpha-ketoglutarate permease HVX45_05735 ENOG4105EIE fructose-bisphosphate aldolase HVX45_05740 ENOG4105EAA nucleoside HVX45_05745 ENOG4108KD5 ADP-ribosylation crystallin J1 HVX45_05750 ENOG4108TFM Kinase, PfkB family HVX45_05755 ENOG4105FDP GntR family transcriptional regulator HVX45_05760 ENOG4108UQ1 hydrolase, family 25 HVX45_05765 ENOG4105DWF phosphomethylpyrimidine kinase HVX45_05775 ENOG4108Z1S Influences nickel and cobalt homeostasis. May act by modulating RcnA-mediated export of these ions to avoid excess efflux. Not involved in nickel import and does not bind nickel or cobalt ions directly HVX45_05780 ENOG410662B Type-1 fimbrial protein HVX45_05785 ENOG4105CW0 outer membrane usher protein HVX45_05790 ENOG4108MQF Chaperone HVX45_05800 ENOG41067AK Protein of unknown function (DUF2574) HVX45_05805 ENOG4105D1F ATP-binding protein HVX45_05815 ENOG4108KDT Molybdate metabolism regulator HVX45_05820 ENOG4108KDT Molybdate metabolism regulator HVX45_05825 ENOG4108KDT Molybdate metabolism regulator HVX45_05830 ENOG4108KDT Molybdate metabolism regulator HVX45_05840 ENOG4105KKX ATPase associated with various cellular activities aaa_5 HVX45_05845 ENOG4105RD5 HVX45_05850 ENOG4105DEG Vwa containing coxe family protein HVX45_05855 ENOG410903U zinc ion binding HVX45_05860 ENOG4108YCW (LipO)protein HVX45_05865 ENOG4108W15 Protein of unknown function (DUF1456) HVX45_05870 ENOG4108NEV two component transcriptional regulator, LytTR family HVX45_05875 ENOG4108HRK Histidine kinase HVX45_05880 ENOG4108XDN Transcriptional regulator HVX45_05890 ENOG4105WJV Binding-protein-dependent transport systems, inner membrane component HVX45_05895 ENOG4108IJ8 ABC transporter HVX45_05900 ENOG4107T5X Binding-protein-dependent transport systems, inner membrane component HVX45_05905 ENOG4107SI7 Substrate-binding region of abc-type glycine betaine transport system HVX45_05910 ENOG4107QK4 glycoside hydrolase, family 3 domain protein HVX45_05915 ENOG4105CXG d-lactate dehydrogenase HVX45_05920 ENOG41061WM D-Alanyl-D-Alanine HVX45_05925 ENOG41069YE inner membrane protein yohC HVX45_05930 ENOG4105KHU inner membrane protein YohD HVX45_05935 ENOG4105H9W Short-chain dehydrogenase reductase Sdr HVX45_05945 ENOG4105FBT Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs (By similarity) HVX45_05955 ENOG41067MG lrgb family HVX45_05965 ENOG4107GZ4 SanA protein HVX45_05970 ENOG4105Y9N Membrane HVX45_05975 ENOG4105BZ8 glutamate synthase HVX45_05980 ENOG4107SJI Dehydrogenase HVX45_05985 ENOG4108HWV )-transporter HVX45_05990 ENOG4105C2J ABC transporter HVX45_05995 ENOG4105EMA Periplasmic binding protein LacI transcriptional regulator HVX45_06000 ENOG41060NJ transcriptional regulator HVX45_06005 ENOG4105DHF Membrane HVX45_06020 ENOG4105D05 Receptor HVX45_06025 ENOG4108IQI permease HVX45_06030 ENOG4105DUM transcriptional regulator, lysR family HVX45_06035 ENOG4105HMI Membrane HVX45_06045 ENOG4105DD7 kinase (PfkB family HVX45_06050 ENOG4105D9N nucleoside HVX45_06060 ENOG4108Y4K DNA-binding transcriptional activator HVX45_06065 ENOG4105D9N nucleoside HVX45_06070 ENOG4105D53 Catalyzes the hydrolysis of pseudouridine 5'-phosphate (PsiMP) to ribose 5-phosphate and uracil (By similarity) HVX45_06075 ENOG4105DD7 kinase (PfkB family HVX45_06080 ENOG4105DM4 PTS System HVX45_06085 ENOG4105DE4 1-phosphofructokinase HVX45_06090 ENOG4105DTZ bifunctional PTS system fructose-specific transporter subunit IIA HPr protein HVX45_06095 ENOG4105S8Q sugar efflux transporter HVX45_06100 ENOG4105KRS Proteinase inhibitor HVX45_06110 ENOG4105DEI Mannitol dehydrogenase HVX45_06115 ENOG4105CKI cobalamin synthesis protein HVX45_06120 ENOG41076MN Phosphoesterase, PA-phosphatase related HVX45_06125 ENOG4107TT5 NLP P60 protein HVX45_06130 ENOG4105CXC rtn protein HVX45_06135 ENOG4105E43 Extracellular solute-binding protein, family 5 HVX45_06140 ENOG4108I5X binding-protein-dependent transport systems inner membrane Component HVX45_06145 ENOG4108IYQ Binding-protein-dependent transport systems inner membrane component HVX45_06150 ENOG4108JQ5 ABC transporter HVX45_06155 ENOG4105HG6 HVX45_06160 ENOG4105C2C drug resistance transporter, Bcr CflA HVX45_06165 ENOG4105I08 Pseudouridine synthase HVX45_06170 ENOG4105CFI type iii restriction protein res subunit HVX45_06195 ENOG4105E68 Sulfatase HVX45_06210 ENOG410658X HVX45_06215 ENOG4105WH1 Two component transcriptional regulator luxr family HVX45_06220 ENOG4105KWW Biogenesis protein HVX45_06225 ENOG4107QX9 Thiol disulfide interChange protein HVX45_06230 ENOG4105DA4 cytochrome c-type biogenesis protein HVX45_06240 ENOG4105X3C heme exporter protein HVX45_06245 ENOG41060IM Heme exporter protein HVX45_06250 ENOG4105CA5 Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes (By similarity) HVX45_06255 ENOG4107EV4 once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system (By similarity) HVX45_06260 ENOG4105CUW cytochrome C-TYPE protein HVX45_06265 ENOG4108ZMS Electron transfer subunit of the periplasmic nitrate reductase complex NapAB (By similarity) HVX45_06270 ENOG4105GXZ Ferredoxin-type protein NapH HVX45_06275 ENOG4108BGM Quinol dehydrogenase periplasmic component HVX45_06285 ENOG41061Q0 Assembly protein for periplasmic nitrate reductase HVX45_06290 ENOG4108ZNS ferredoxin-type protein NapF HVX45_06300 ENOG4105D8X mechanosensitive ion channel HVX45_06310 ENOG4105ZY9 UPF0379 protein ybiM HVX45_06315 ENOG4108IU3 tonb-dependent siderophore receptor HVX45_06325 ENOG4105KSC Transcriptional regulator, TraR DksA family HVX45_06330 ENOG4105VR4 UPF0379 protein ybiJ HVX45_06335 ENOG4105DG4 malate L-lactate dehydrogenase HVX45_06340 ENOG4108MTB glycosyl transferase family HVX45_06345 ENOG4105DVT helicase HVX45_06350 ENOG4105C1J atp-dependent rna helicase HVX45_06355 ENOG4107MVR Transcriptional regulator HVX45_06365 ENOG4105CJ1 ABC, transporter HVX45_06370 ENOG4107QWP ABC-2 type transporter HVX45_06375 ENOG4107QWP ABC-2 type transporter HVX45_06380 ENOG4105I9U inner membrane protein ybhQ HVX45_06385 ENOG4105X23 Endonuclease Exonuclease phosphatase HVX45_06390 ENOG4105DZQ phospholipase D Transphosphatidylase HVX45_06395 ENOG4107UXM Membrane HVX45_06400 ENOG410733J conserved inner membrane protein HVX45_06405 ENOG4105DIJ Phosphoethanolamine transferase HVX45_06410 ENOG4105HFZ Membrane HVX45_06415 ENOG4108ZAF Molybdopterin HVX45_06420 ENOG4105M00 molybdopterin converting factor, subunit 1 HVX45_06430 ENOG4108RIR Molybdenum cofactor biosynthesis protein HVX45_06440 ENOG4105CHW UPF0052 protein HVX45_06450 ENOG4105E78 Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring (By similarity) HVX45_06455 ENOG410626R Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl- L-methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway (By similarity) HVX45_06470 ENOG4108JPX Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor (By similarity) HVX45_06475 ENOG4108V1U phospholipid-binding protein HVX45_06480 ENOG4105IHM Involved in O antigen modification. Involved in the translocation of bactoprenol-linked glucose across the cytoplasmic membrane (By similarity) HVX45_06485 ENOG4105CKK Glycosyl transferase, family 2 HVX45_06585 ENOG4108N0N Phage Terminase Large Subunit HVX45_06605 ENOG4106050 phage regulatory protein, rha family HVX45_06610 ENOG4105SZK Rz endopeptidase from lambdoid prophage DLP12 HVX45_06640 ENOG4105RWQ Protein of unknown function (DUF1364) HVX45_06680 ENOG4105CDU Replicative dna helicase HVX45_06775 ENOG41077V0 CPS-53 (KpLE1) prophage HVX45_06805 ENOG4108I1J Integrase HVX45_06810 ENOG4105NBR Pectinesterase HVX45_06820 ENOG4108K4B hydrolase HVX45_06830 ENOG4105E0C molybdate abc transporter HVX45_06835 ENOG4108S6J ABC transporter, periplasmic molybdate-binding protein HVX45_06845 ENOG4105F4R Transcriptional regulator mode HVX45_06850 ENOG4105DKW ABC transporter HVX45_06855 ENOG4105CMR udp-glucose 4-epimerase HVX45_06860 ENOG4105F0Z galactose-1-phosphate uridylyltransferase HVX45_06870 ENOG4105ENN converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity) HVX45_06880 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) HVX45_06885 ENOG4105JND homeobox protein HVX45_06890 ENOG4105PGM cation diffusion facilitator family transporter HVX45_06895 ENOG4106Z1T Nicotinamide Mononucleotide Transporter HVX45_06940 ENOG4105UFD tol-pal system protein YbgF HVX45_06945 ENOG4105KCK Peptidoglycan-associated lipoprotein HVX45_06955 ENOG4108Z82 Cell envelope integrity inner membrane protein TolA HVX45_06965 ENOG4105E02 MotA TolQ exbB proton channel HVX45_06970 ENOG4107YD3 Thioesterase HVX45_06975 ENOG4105KJB cyd operon protein YbgE HVX45_06985 ENOG4105CFY cytochrome d ubiquinol oxidase, subunit ii HVX45_06990 ENOG4105C4M (Ubiquinol oxidase) subunit I HVX45_06995 ENOG4105C8I hydrolase, family 38 HVX45_07000 ENOG4105DM4 PTS System HVX45_07005 ENOG4105FDP GntR family transcriptional regulator HVX45_07010 ENOG4107WFU Glutamate mutase subunit sigma HVX45_07020 ENOG4105DJI Methylaspartate mutase, E subunit HVX45_07045 ENOG4107GFK fumarate HVX45_07050 ENOG4105ETT transcriptional Regulator, LysR family HVX45_07055 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha HVX45_07065 ENOG4105C7S Dehydrogenase HVX45_07070 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 HVX45_07075 ENOG4105E33 succinate dehydrogenase HVX45_07080 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) HVX45_07085 ENOG4105N1I succinate dehydrogenase, hydrophobic membrane anchor protein HVX45_07090 ENOG4108UTY succinate dehydrogenase, cytochrome b556 subunit HVX45_07095 ENOG4105BZN citrate synthase HVX45_07100 ENOG4106UBK fimbrial-like adhesin protein HVX45_07105 ENOG4106PG1 outer membrane usher protein HVX45_07110 ENOG4108TTM chaperone HVX45_07115 ENOG4108MY7 Fimbrial HVX45_07120 ENOG4108KK1 membrane protein AbrB duplication HVX45_07145 ENOG4107R7A Allophanate hydrolase subunit 2 HVX45_07150 ENOG4105P4J Allophanate hydrolase, subunit 1 HVX45_07155 ENOG4107QNR UPF0135 protein HVX45_07160 ENOG4105DUX Transporter HVX45_07165 ENOG4105CVP deoxyribo-dipyrimidine photolyase HVX45_07170 ENOG4107SEY Conserved Protein HVX45_07200 ENOG4105XIQ Protein of unknown function (DUF2517) HVX45_07225 ENOG4105C08 Histidine kinase HVX45_07230 ENOG4105EEX Two component transcriptional regulator (Winged helix family HVX45_07235 ENOG4105CXN decarboxylase HVX45_07240 ENOG4105D5Q Arginine ornithine antiporter HVX45_07245 ENOG4107QIX Phosphoglucomutase (EC 5.4.2.2 HVX45_07250 ENOG4107CDU Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated (By similarity) HVX45_07255 ENOG4105EV9 Alpha Beta Hydrolase HVX45_07260 ENOG4105NNH LexA regulated protein HVX45_07265 ENOG4105MHQ Low-potential electron donor to a number of redox enzymes (By similarity) HVX45_07275 ENOG41090R7 Ferric uptake HVX45_07280 ENOG4105GX6 (LipO)protein HVX45_07295 ENOG4105CI1 PTS System HVX45_07305 ENOG4105CE4 GlcNAc 6-P deacetylase HVX45_07310 ENOG4105E2R ROK family HVX45_07315 ENOG4105D4U had-superfamily hydrolase, subfamily iia HVX45_07320 ENOG4105CAQ asparagine synthetase HVX45_07370 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family HVX45_07380 ENOG4105C9A Phoh family HVX45_07390 ENOG4108JU5 Magnesium and cobalt efflux protein HVX45_07395 ENOG4105CE8 Transfers the fatty acyl group on membrane lipoproteins (By similarity) HVX45_07400 ENOG4107U91 Rhomboid family HVX45_07405 ENOG4107RP9 extracellular solute-binding protein, family 3 HVX45_07410 ENOG4105EAD ABC transporter HVX45_07415 ENOG4105DRP amino acid AbC transporter HVX45_07420 ENOG4105CDA abc transporter atp-binding protein HVX45_07430 ENOG4105F7F Chaperone HVX45_07435 ENOG4105QFC Hsc56 co-chaperone of HscC HVX45_07440 ENOG41069CF Protein of unknown function (DUF1266) HVX45_07445 ENOG4107JFD Sel1 repeat HVX45_07450 ENOG4105QFC Hsc56 co-chaperone of HscC HVX45_07455 ENOG41069CF Protein of unknown function (DUF1266) HVX45_07460 ENOG4105EUU Sel1 domain protein repeat-containing protein HVX45_07465 ENOG4107PAI alpha helical protein HVX45_07480 ENOG4105DJF DNA polymerase III, delta' subunit HVX45_07490 ENOG4105KEM Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation (By similarity) HVX45_07500 ENOG4105CJN penicillin-binding protein HVX45_07505 ENOG4105CNI cell division protein FtsW HVX45_07510 ENOG4105K6T rare lipoprotein A HVX45_07515 ENOG4105DZ1 carboxypeptidase HVX45_07525 ENOG4108BDP Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity) HVX45_07555 ENOG41079UR PagP is required both for biosynthesis of hepta-acylated lipid A species containing palmitate and for resistance to cationic antimicrobial peptides (CAMPs). It catalyzes the transfer of a palmitate chain (16 0) from the sn-1 position of a glycerophospholipid to the free hydroxyl group of the (R)-3- hydroxymyristate chain at position 2 of lipid A (endotoxin) (By similarity) HVX45_07560 ENOG4105CEE C4-dicarboxylate transporter HVX45_07565 ENOG4105KTS ribonuclease HVX45_07570 ENOG4105NXH GreA GreB family elongation factor HVX45_07575 ENOG4108U51 Universal stress protein HVX45_07580 ENOG4108JU3 Alkyl hydroperoxide reductase HVX45_07585 ENOG4105D3R alkyl hydroperoxide reductase HVX45_07590 ENOG4108KHN disulfide isomerase, thiol-disulfide oxidase HVX45_07595 ENOG4105DQS Transcriptional regulator HVX45_07600 ENOG4105BZV Phosphoadenosine phosphosulfate reductase HVX45_07605 ENOG4105GTN ParB Domain Protein Nuclease HVX45_07610 ENOG4105CHM Aminotransferase HVX45_07615 ENOG4107SCQ Iron-containing alcohol dehydrogenase HVX45_07620 ENOG4105VCD cytoplasmic protein HVX45_07625 ENOG4105D22 carbon starvation protein HVX45_07630 ENOG4108TZA Required for optimal enterobactin synthesis. Acts as a proofreading enzyme that prevents EntB misacylation by hydrolyzing the thioester bound existing between EntB and wrongly charged molecules (By similarity) HVX45_07635 ENOG4105X17 23-dihydro-2,3-dihydroxybenzoate dehydrogenase HVX45_07640 ENOG4105WQI isochorismatase HVX45_07645 ENOG4108IQC 2,3-dihydroxybenzoate-AMP ligase HVX45_07650 ENOG4105E4F Isochorismate synthase HVX45_07655 ENOG4105PEC Iron-enterobactin transporter periplasmic binding protein HVX45_07665 ENOG4105DQ5 transport system permease protein HVX45_07670 ENOG4105TVJ transport system, permease HVX45_07675 ENOG4105E0A ABC, transporter HVX45_07680 ENOG4108QY5 Ferric enterobactin transport protein HVX45_07685 ENOG4105C0W non-ribosomal peptide synthetase HVX45_07690 ENOG41085A6 mbth domain-containing protein HVX45_07695 ENOG4105E93 esterase HVX45_07700 ENOG4107RNH Outer membrane receptor FepA HVX45_07705 ENOG4108TSE Transferase HVX45_07710 ENOG4108IUS Transketolase HVX45_07715 ENOG4108HHA Transketolase HVX45_07720 ENOG4105DKT Transcriptional regulator HVX45_07725 ENOG4107QVN Key enzyme in the regulation of glycerol uptake and metabolism (By similarity) HVX45_07730 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator HVX45_07740 ENOG4105C2J ABC transporter HVX45_07745 ENOG4105CNN ABC, transporter HVX45_07770 ENOG4105WQ6 Membrane HVX45_07775 ENOG4105MSB protein, conserved in bacteria HVX45_07780 ENOG4108RCM Nitroreductase HVX45_07785 ENOG4105CUY Mechanosensitive ion channel HVX45_07790 ENOG4105C85 amino acid HVX45_07795 ENOG4108IJF Heavy metal efflux pump, CzcA HVX45_07800 ENOG4105EP1 Efflux transporter rnd family, mfp subunit HVX45_07805 ENOG410624V efflux system protein HVX45_07810 ENOG4105ENJ RND efflux system, outer membrane lipoprotein HVX45_07815 ENOG4105CK6 Two component transcriptional regulator (Winged helix family HVX45_07820 ENOG4105GR3 Histidine kinase HVX45_07855 ENOG4107QMP dna polymerase iii subunits gamma and tau HVX45_07865 ENOG4105WD1 Membrane HVX45_07870 ENOG4108URS primosomal replication protein n'' HVX45_07875 ENOG4106428 Protein of unknown function (DUF2496) HVX45_07880 ENOG4105EGS Mechanosensitive ion channel HVX45_07885 ENOG4107XI7 Tetr family transcriptional regulator HVX45_07890 ENOG4105C1P efflux transporter, rnd family, mfp subunit HVX45_07895 ENOG4105BZS acriflavin resistance protein HVX45_07900 ENOG4108UKR Biofilm formation regulator YbaJ HVX45_07910 ENOG4105GSJ Inner membrane protein ylaC HVX45_07915 ENOG41066DG (EAL) domain protein HVX45_07920 ENOG4105KCV RNA signal recognition particle 4.5S RNA HVX45_07930 ENOG41080UX Methyltransferase HVX45_07935 ENOG4108MNP Glycoprotein polysaccharide metabolism HVX45_07940 ENOG4105C29 acyl-CoA thioesterase HVX45_07945 ENOG4105BZU Histidine kinase HVX45_07950 ENOG4108YZA Nitrogen regulatory protein pii HVX45_07955 ENOG4105BZ1 (ABC) transporter HVX45_07960 ENOG4105BZ1 (ABC) transporter HVX45_07965 ENOG4108XM1 transcriptional regulator AsnC family HVX45_07975 ENOG4108NFA extracellular solute-binding protein HVX45_07985 ENOG4108TGP Thioesterase superfamily protein HVX45_07990 ENOG41083P1 competence protein ComEA helix-hairpin-helix repeat protein HVX45_07995 ENOG4105EIN peptidylprolyl cis-trans isomerase HVX45_08000 ENOG4105K70 DNA-binding protein HVX45_08005 ENOG4105C6P ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity) HVX45_08025 ENOG4105M85 Bola protein HVX45_08030 ENOG4105IEY (LipO)protein HVX45_08035 ENOG4105EYM Major Facilitator superfamily HVX45_08040 ENOG4105E2S oxidase) subunit II HVX45_08045 ENOG4105BZ9 Cytochrome C oxidase, subunit I HVX45_08050 ENOG4105CCU oxidase (Subunit III) HVX45_08055 ENOG41090KH cytochrome o ubiquinol oxidase (subunit iv) HVX45_08075 ENOG4107HP6 Transcriptional regulator HVX45_08080 ENOG4107V59 shikimate HVX45_08085 ENOG4105DAB fumarate reductase succinate dehydrogenase flavoprotein domain protein HVX45_08095 ENOG4105DAB fumarate reductase succinate dehydrogenase flavoprotein domain protein HVX45_08105 ENOG4105D2S major facilitator superfamily HVX45_08110 ENOG4107RDB Major Facilitator HVX45_08120 ENOG4108JZF Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity) HVX45_08125 ENOG4107S0N DJ-1 family HVX45_08130 ENOG4105D8I Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity) HVX45_08140 ENOG4105CTB Polyprenyl synthetase HVX45_08150 ENOG4105CPC Aldo Keto reductase HVX45_08155 ENOG4108ZAI phosphatidylglycerophosphatase a HVX45_08160 ENOG4105CG2 Catalyzes the ATP-dependent phosphorylation of thiamine- monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1 (By similarity) HVX45_08170 ENOG4108UTT Catalyzes the formation of 6,7-dimethyl-8- ribityllumazine by condensation of 5-amino-6-(D- ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin (By similarity) HVX45_08175 ENOG4105D1W Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate (By similarity) HVX45_08185 ENOG4108KIC (LipO)protein HVX45_08190 ENOG4105DRB nucleoside-specific channel-forming protein HVX45_08195 ENOG4105N1F Hnh endonuclease HVX45_08200 ENOG4107RAB Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) HVX45_08205 ENOG4107QN8 Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA (By similarity) HVX45_08210 ENOG4105VIE preprotein translocase, subunit YajC HVX45_08230 ENOG4107R28 alpha amylase, catalytic region HVX45_08235 ENOG4105C85 amino acid HVX45_08240 ENOG4105CWM branched-chain amino acid transport system II carrier protein HVX45_08245 ENOG4105BZU Histidine kinase HVX45_08255 ENOG4107RH8 nuclease SbcCD subunit D HVX45_08260 ENOG4105EYH Exonuclease HVX45_08265 ENOG4105DKQ ROK family HVX45_08280 ENOG4105HBA AroM protein HVX45_08285 ENOG4105SS3 HVX45_08300 ENOG4105II7 pyrroline-5-carboxylate reductase HVX45_08305 ENOG4105BZU Histidine kinase HVX45_08310 ENOG4105VIF phosphate starvation-inducible protein HVX45_08325 ENOG4105CPF Cell wall formation (By similarity) HVX45_08330 ENOG4105UNH Membrane HVX45_08335 ENOG4105FR5 inner membrane protein YaiY HVX45_08340 ENOG4107QS8 (LipO)protein HVX45_08345 ENOG4108DQG in Escherichia coli SbmA is involved in uptake of microcin J25 HVX45_08350 ENOG4107R6D beta-lactam binding protein AmpH HVX45_08355 ENOG4108PNB DNA-binding transcriptional regulator HVX45_08360 ENOG4108NSE outer membrane autotransporter barrel HVX45_08365 ENOG4105D52 delta-aminolevulinic acid dehydratase HVX45_08370 ENOG4105E2B Taurine dioxygenase HVX45_08375 ENOG4105EUS Binding-protein-dependent transport systems, inner membrane component HVX45_08380 ENOG4108IY8 ABC, transporter HVX45_08385 ENOG4106FTQ Taurine ABC transporter, periplasmic HVX45_08390 ENOG4107W19 lmbE family HVX45_08400 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) HVX45_08405 ENOG4105DXD 2-methylcitrate dehydratase HVX45_08410 ENOG4105BZN citrate synthase HVX45_08415 ENOG4105CR4 methylisocitrate lyase HVX45_08420 ENOG4108JU7 Transcriptional regulator HVX45_08425 ENOG4105TDT uncharacterized protein yahO HVX45_08430 ENOG4105E82 cytochrome subunit of dehydrogenase HVX45_08435 ENOG4105BZU Histidine kinase HVX45_08440 ENOG4105C6F GntR Family Transcriptional Regulator HVX45_08445 ENOG4105CPQ Dehydrogenase HVX45_08450 ENOG4108I5G Major Facilitator superfamily HVX45_08455 ENOG4105BZU Histidine kinase HVX45_08465 ENOG4105BZU Histidine kinase HVX45_08470 ENOG4108HF7 Gcn5-related n-acetyltransferase HVX45_08480 ENOG4107SET aldo keto reductase HVX45_08485 ENOG4105EQ2 LysR family Transcriptional regulator HVX45_08505 ENOG4105UZW Tail fiber assembly protein HVX45_08510 ENOG410685N tail fiber protein HVX45_08590 ENOG4105IM0 capsid protein HVX45_08600 ENOG4105F7J membrane-bound serine protease HVX45_08610 ENOG4107DE1 head-to-tail joining protein HVX45_08615 ENOG4105UZW Tail fiber assembly protein HVX45_08620 ENOG4105FKG DNA packaging protein HVX45_08625 ENOG4106YSC HVX45_08630 ENOG41064WM Uncharacterized protein YcgX HVX45_08640 ENOG4105SZK Rz endopeptidase from lambdoid prophage DLP12 HVX45_08645 ENOG4105KUS lysozyme HVX45_08650 ENOG4105QFS Lysis protein S homolog from lambdoid prophage HVX45_08655 ENOG4108MIW Induces the synthesis of acid phosphatase (AppA) and several other polypeptides (such as AppBC) during the deceleration phase of growth. It also acts as a transcriptional repressor for one group of proteins that are synthesized preferentially in exponential growth and for one group synthesized only in the stationary phase. Also involved in the stabilization of the sigma stress factor RpoS during stress conditions HVX45_08660 ENOG4107SEY Conserved Protein HVX45_08670 ENOG4105HRS Antitermination protein HVX45_08680 ENOG4106CZA Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC (By similarity) HVX45_08685 ENOG4105RWQ Protein of unknown function (DUF1364) HVX45_08690 ENOG410757E Protein NinE homolog from lambdoid prophage DLP12 HVX45_08695 ENOG4108V2F protein ybcN in lambdoid DLP12 prophage regi HVX45_08795 ENOG4108KU3 Integrase HVX45_08815 ENOG4105FCK Membrane HVX45_08835 ENOG4105CIN aminoacyl-histidine dipeptidase HVX45_08850 ENOG4108S2Y peptide Chain Release factor HVX45_08860 ENOG4108HYG acetyltransferase HVX45_08875 ENOG4107RD7 Flagellar Motor Protein, MotA HVX45_08905 ENOG410804A Flagellar hook-associated 2 domain-containing protein HVX45_08910 ENOG4105I03 Flagellin HVX45_08925 ENOG4105DTJ flagellar hook-associated protein HVX45_08935 ENOG4108ZW7 flagellar rod assembly protein muramidase flgj HVX45_08950 ENOG4105CGA flagellar basal-body rod protein FlgG HVX45_08955 ENOG4108KPB Flagellar basal-body rod protein FlgF HVX45_08960 ENOG4105BZE flagellar hook protein, FlgE HVX45_08970 ENOG4108ZC9 flagellar basal-body rod protein flgc HVX45_08975 ENOG4105K88 Structural component of flagellum, the bacterial motility apparatus. Part of the rod structure of flagellar basal body (By similarity) HVX45_09015 ENOG4105CNA YD repeat protein HVX45_09035 ENOG410600T transposase HVX45_09050 ENOG4107ZIC Glycerol-3-phosphate cytidylyltransferase HVX45_09060 ENOG4108JIR Flagellum-specific ATP synthase HVX45_09070 ENOG4105CS3 FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation (By similarity) HVX45_09075 ENOG4105C1F The M ring may be actively involved in energy transduction (By similarity) HVX45_09095 ENOG4105DD5 Flagellar motor switch protein HVX45_09100 ENOG4105CN7 Flagellar biosynthetic protein FliP HVX45_09105 ENOG4105VS8 Flagellar biosynthetic protein fliq HVX45_09110 ENOG4105D19 Role in flagellar biosynthesis (By similarity) HVX45_09115 ENOG4105D00 flagellar biosynthetic protein flhB HVX45_09125 ENOG4107QYX exodeoxyribonuclease v alpha HVX45_09130 ENOG4107QKA exodeoxyribonuclease V beta HVX45_09135 ENOG4107QXK peptidase HVX45_09140 ENOG4105DSY exodeoxyribonuclease V, gamma HVX45_09145 ENOG4105RVB Prepilin peptidase dependent protein c HVX45_09150 ENOG4105SEN Protein of unknown function (DUF2509) HVX45_09155 ENOG4105JCS prepilin peptidase dependent protein HVX45_09160 ENOG4105IPU prepilin peptidase dependent protein A HVX45_09175 ENOG4108HRM phosphoenolpyruvate--protein phosphotransferase HVX45_09190 ENOG4105EE5 Membrane protein terC HVX45_09195 ENOG4105SUV lipoprotein YgdR HVX45_09200 ENOG4105CPC Aldo Keto reductase HVX45_09225 ENOG41060NJ transcriptional regulator HVX45_09235 ENOG4105RQF LysR family Transcriptional regulator HVX45_09240 ENOG4105CHU acetyl-coa acetyltransferase HVX45_09245 ENOG4108MHD transport protein HVX45_09250 ENOG4105ISV protein with bipartite regulator domain HVX45_09255 ENOG4108TC1 Transcriptional regulator HVX45_09265 ENOG410802X bacteriophage n4 adsorption protein b HVX45_09270 ENOG41090FC Bacteriophage N4 receptor, outer membrane subunit HVX45_09275 ENOG4105QUW HVX45_09280 ENOG4105DQW permease for cytosine purines, uracil, thiamine, allantoin HVX45_09285 ENOG4105DZC cytosine deaminase HVX45_09305 ENOG4105TNG K13735 adhesin invasin HVX45_09380 ENOG4105DFP Integrase HVX45_09390 ENOG4108K5P (LipO)protein HVX45_09395 ENOG4105MP9 class II Aldolase HVX45_09415 ENOG4105C5Q Transcriptional regulator HVX45_09420 ENOG4105H3G oxidoreductase HVX45_09425 ENOG4105KME endoribonuclease L-psp HVX45_09435 ENOG4105CWC Acetylornithine deacetylase HVX45_09440 ENOG4105CVK Glutamate decarboxylase HVX45_09445 ENOG4105CSV Glutaminase HVX45_09450 ENOG4107XKX isoquinoline 1-oxidoreductase, alpha subunit HVX45_09455 ENOG4105DIP Molybdopterin dehydrogenase FAD-binding HVX45_09460 ENOG4105C7W Xanthine dehydrogenase HVX45_09465 ENOG4107XAN XdhC and CoxI family HVX45_09480 ENOG4105CRK lysyL-tRNA synthetase HVX45_09490 ENOG4105C2R Single-stranded-DNA-specific exonuclease (RecJ) HVX45_09495 ENOG4105T95 Thiol disulfide interChange protein HVX45_09500 ENOG4105C13 Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HVX45_09505 ENOG41071R3 Low-potential electron donor to a number of redox enzymes (By similarity) HVX45_09510 ENOG4108YDB Toxic component of a toxin-antitoxin (TA) module. Overexpression leads to growth arrest after 5 hours, with initial elongation of cells, followed by swelling. The toxic effects are abrogated by coexpression with antitoxin CptB. Interacts with cytoskeletal proteins FtsZ and MreB HVX45_09515 ENOG4105Y75 tpr repeat protein HVX45_09525 ENOG4108UT2 hemolysin iii HVX45_09530 ENOG4105N5Z UPF0267 protein HVX45_09535 ENOG4105CS2 ec 3.2.1.21 HVX45_09565 ENOG4105EAK ubiquinone biosynthesis hydroxylase, ubiH ubiF VisC COQ6 family HVX45_09570 ENOG4105D0A hydroxylase HVX45_09575 ENOG4107RAQ aminopeptidase HVX45_09595 ENOG4105MK2 5-formyltetrahydrofolate cyclo-ligase HVX45_09605 ENOG4108JQ1 Dehydrogenase HVX45_09620 ENOG4105MPN Membrane HVX45_09625 ENOG4108ZUB Lysine exporter protein (Lyse ygga) HVX45_09630 ENOG4105D64 Mechanosensitive ion channel HVX45_09635 ENOG4105D2N Aldolase HVX45_09650 ENOG4107Z1W Fructose transport system kinase HVX45_09655 ENOG4108R4K DNA-binding, transcriptional regulator HVX45_09660 ENOG4108Q8A Fructose-1,6-bisphosphatase HVX45_09665 ENOG4105DXH Alcohol dehydrogenase zinc-binding domain protein HVX45_09670 ENOG4105CTS PTS system mannitol-specific HVX45_09675 ENOG4108X7Y Mannitol-specific cryptic phosphotransferase enzyme iia HVX45_09680 ENOG4105EPW hflc protein HVX45_09685 ENOG4105CV1 Transketolase (EC 2.2.1.1) HVX45_09690 ENOG4108K0D peptidase, M48 HVX45_09705 ENOG4105DP5 Catalyzes the biosynthesis of agmatine from arginine (By similarity) HVX45_09730 ENOG4107QNK )-transporter HVX45_09740 ENOG4105RWS endonuclease I HVX45_09745 ENOG4105QF0 Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity) HVX45_09750 ENOG4105D7Z glutathione synthase HVX45_09765 ENOG4105CZX twitching motility protein HVX45_09770 ENOG4105DFA alanine racemase domain protein HVX45_09775 ENOG4108VIA integral membrane protein HVX45_09785 ENOG4108V82 Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP dITP to their respective monophosphate derivatives. Might exclude non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) HVX45_09790 ENOG4105CSA Coproporphyrinogen iii oxidase HVX45_09795 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit HVX45_09800 ENOG41069H7 transport system small permease component HVX45_09805 ENOG4105CG6 trap dicarboxylate transporter dctm subunit HVX45_09810 ENOG4106MH3 alpha helix chain HVX45_09815 ENOG4105HDK L-asparaginase HVX45_09820 ENOG4105K33 Periplasmic Protein HVX45_09825 ENOG41090ED Protein with unknown function (DUF469) HVX45_09835 ENOG4105CEN a g-specific adenine glycosylase HVX45_09850 ENOG4105EAA nucleoside HVX45_09855 ENOG4105CXN decarboxylase HVX45_09860 ENOG4108UQV Membrane HVX45_09885 ENOG4105EHH Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue (By similarity) HVX45_09905 ENOG4107QHF type ii secretion system protein e HVX45_09910 ENOG4105D7Q type ii secretion system HVX45_09915 ENOG4108VAU general secretion pathway protein G HVX45_09925 ENOG4105X5Z General secretion pathway protein I HVX45_09945 ENOG4105U1E general secretion pathway protein M HVX45_09950 ENOG410600K aminopeptidase HVX45_09970 ENOG4106032 Glutathionylspermidine synthase HVX45_09980 ENOG4105CYM Glutathione S-transferase HVX45_09985 ENOG41082MF Hydrogenase assembly chaperone hypC hupF HVX45_09995 ENOG4108WGS hydrogenase 2-specific chaperone HVX45_10000 ENOG4108USZ hydrogenase HVX45_10005 ENOG4105DPX Hydrogenase, large subunit HVX45_10010 ENOG4105CJ5 hydrogenase 2 b cytochrome subunit HVX45_10015 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein HVX45_10020 ENOG4105E3S small subunit HVX45_10025 ENOG410900S Protein of unknown function (DUF2623) HVX45_10035 ENOG4105CPC Aldo Keto reductase HVX45_10045 ENOG4105CYX Short-chain dehydrogenase reductase Sdr HVX45_10050 ENOG4108ZZF transport protein (ExbD) HVX45_10055 ENOG4105CWK Biopolymer transport protein, ExbB HVX45_10060 ENOG4105C28 cystathionine HVX45_10065 ENOG4108K81 inner membrane protein YghB HVX45_10070 ENOG4105CF7 AraC family transcriptional regulator HVX45_10075 ENOG4108I6A alcohol dehydrogenase HVX45_10080 ENOG4105CV8 reductase HVX45_10085 ENOG4107QPK )-transporter HVX45_10095 ENOG4105CCT upf0313 protein HVX45_10100 ENOG4107YCY Transcriptional regulator HVX45_10105 ENOG4105DEI Mannitol dehydrogenase HVX45_10110 ENOG4105CPQ Dehydrogenase HVX45_10115 ENOG4105DG4 malate L-lactate dehydrogenase HVX45_10120 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit HVX45_10130 ENOG4105CG6 trap dicarboxylate transporter dctm subunit HVX45_10135 ENOG4107TZ2 Cell division protein that is required for growth during stress conditions. May be involved in protecting or stabilizing the divisomal assembly under conditions of stress (By similarity) HVX45_10140 ENOG4107S7E 1-acyl-sn-glycerol-3-phosphate acyltransferase HVX45_10145 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HVX45_10150 ENOG4105H4F exported protein HVX45_10155 ENOG4105XJC Two component transcriptional regulator (Winged helix family HVX45_10160 ENOG4105DHQ Histidine kinase HVX45_10165 ENOG4105NF4 modulator of drug activity HVX45_10170 ENOG4105VRH Antibiotic biosynthesis monooxygenase HVX45_10175 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HVX45_10180 ENOG4105IPS esterase HVX45_10185 ENOG41070EG Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes (By similarity) HVX45_10190 ENOG4108SX3 cytoplasmic protein HVX45_10195 ENOG41087AY ADP-Ribose pyrophosphatase HVX45_10200 ENOG4105DFG type I secretion outer membrane protein HVX45_10210 ENOG4106032 Glutathionylspermidine synthase HVX45_10215 ENOG4108MR7 Arylsulfotransferase HVX45_10220 ENOG4108N92 Thiol disulfide Interchange Protein HVX45_10230 ENOG4105C8E extradiol ring-cleavage dioxygenase class IIi protein subunit b HVX45_10245 ENOG4105H8W Fimbrial protein HVX45_10255 ENOG4108TTM chaperone HVX45_10260 ENOG4108MY7 Fimbrial HVX45_10270 ENOG4105W0Z cytoplasmic protein HVX45_10280 ENOG4105PV3 Inner membrane protein yqiJ HVX45_10285 ENOG4107S78 Band 7 protein HVX45_10315 ENOG4105I7R Adenylate cyclase HVX45_10320 ENOG4106MWK domain protein HVX45_10335 ENOG4107ZVW dihydroneopterin aldolase HVX45_10345 ENOG4105CPM Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity) HVX45_10355 ENOG4105C9G DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity) HVX45_10360 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HVX45_10380 ENOG4105EM7 Selenocysteine-specific translation elongation factor HVX45_10420 ENOG41080XV Thioredoxin HVX45_10430 ENOG4105Q26 Siderophore-interacting protein HVX45_10435 ENOG4105NTW Transcriptional regulator HVX45_10440 ENOG4107RHT methyl-accepting chemotaxis sensory transducer with Pas Pac sensor HVX45_10450 ENOG4105CBP Major Facilitator HVX45_10460 ENOG4105C6F GntR Family Transcriptional Regulator HVX45_10465 ENOG4105DEI Mannitol dehydrogenase HVX45_10475 ENOG4105Y4Z Outer Membrane Lipoprotein HVX45_10485 ENOG4105KT7 mgtC SapB transporter HVX45_10490 ENOG4105XXV Acid-resistance protein HVX45_10495 ENOG41060V2 Acid-resistance protein HVX45_10500 ENOG4108YK4 Acid-resistance membrane protein HVX45_10505 ENOG4106WJ0 Regulates the expression of several genes involved in acid resistance. Required for the expression of gadA and gadBC, among others, regardless of media or growth conditions. Binds directly to the 20 bp GAD box found in the control regions of both loci HVX45_10510 ENOG4105C1P efflux transporter, rnd family, mfp subunit HVX45_10515 ENOG4105BZS acriflavin resistance protein HVX45_10525 ENOG4108NKV transcriptional regulator HVX45_10530 ENOG4105D6F Phosphatase HVX45_10535 ENOG4108V8F Transcriptional regulator, MarR family HVX45_10560 ENOG41061TZ Short-chain dehydrogenase reductase Sdr HVX45_10565 ENOG4105FUY alpha subunit HVX45_10570 ENOG4107Z7P Ferredoxin HVX45_10575 ENOG4105CSP Major Facilitator Superfamily HVX45_10580 ENOG4106D80 Uncharacterized protein YhaL HVX45_10595 ENOG4105C7B Threonine dehydratase HVX45_10600 ENOG4105DCU 2-hydroxyglutaryl-CoA dehydratase HVX45_10605 ENOG4105CIZ coA-substrate-specific enzyme activase HVX45_10615 ENOG4105CCY NADH flavin oxidoreductase, NADH oxidase HVX45_10620 ENOG4105C8Q Methyl-accepting chemotaxis HVX45_10630 ENOG4108IA2 Sodium pantothenate symporter HVX45_10650 ENOG4108V8F Transcriptional regulator, MarR family HVX45_10655 ENOG4105ERH Fumarylacetoacetate hydrolase HVX45_10660 ENOG4105C26 Dehydrogenase HVX45_10665 ENOG4107THI 3,4-dihydroxyphenylacetate 2,3-dioxygenase HVX45_10695 ENOG4105EFA 4-hydroxyphenylacetate HVX45_10700 ENOG4107UWN reductase HVX45_10705 ENOG4105D22 carbon starvation protein HVX45_10710 ENOG4105VCD cytoplasmic protein HVX45_10715 ENOG4105CKI cobalamin synthesis protein HVX45_10730 ENOG4108F3G Type I restriction-modification system, R subunit HVX45_10740 ENOG4107QTH restriction modification system DNA specificity domain HVX45_10755 ENOG4106DIZ Domain of unknown function (DUF1127) HVX45_10760 ENOG4105C1I TRANSCRIPTIONAl REGULATOR GntR family HVX45_10770 ENOG41083G8 Multidrug resistance protein MdtM HVX45_10775 ENOG4106BRA Membrane HVX45_10825 ENOG4105DQ4 alcohol dehydrogenase HVX45_10830 ENOG4105D7A ATP-binding protein HVX45_10835 ENOG4107S21 permease HVX45_10840 ENOG4105K4T epimerase HVX45_10845 ENOG4107R7Y intracellular protease Pfpi family HVX45_10860 ENOG4108YYD acetyltransferase HVX45_10880 ENOG4105DEN Luciferase family HVX45_10885 ENOG4105F7V ErfK ybiS ycfS ynhG family protein HVX45_10930 ENOG4106063 Acetyl-CoA carboxylase biotin carboxyl carrier protein subunit HVX45_10950 ENOG4108K70 Transcriptional regulator HVX45_10955 ENOG4105CIC tryptophan-specific transport protein HVX45_10960 ENOG4105C1J atp-dependent rna helicase HVX45_11000 ENOG4105CHV Transcription elongation factor NusA HVX45_11020 ENOG4105DIJ Phosphoethanolamine transferase HVX45_11030 ENOG4105NTZ Preprotein translocase subunit SecG HVX45_11040 ENOG4105EEI dihydropteroate synthase HVX45_11045 ENOG4105C3H Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity) HVX45_11055 ENOG4105HBR Rna-binding protein HVX45_11060 ENOG4108UKH Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity) HVX45_11065 ENOG4106HRJ d-alanyl-d-alanine carboxypeptidase HVX45_11075 ENOG4105QYV Membrane HVX45_11090 ENOG4105EAH synthase HVX45_11095 ENOG4105HVQ Regulatory factor of maltose metabolism HVX45_11105 ENOG4105VFK BolA family HVX45_11110 ENOG4105UE2 Part of the ABC transporter complex MlaFEDB that actively prevents phospholipid accumulation at the cell surface. Probably maintains lipid asymmetry in the outer membrane by retrograde trafficking of phospholipids from the outer membrane to the inner membrane HVX45_11115 ENOG4105E3I toluene tolerance HVX45_11120 ENOG4107PE3 Mammalian cell entry related domain protein HVX45_11125 ENOG4105CY3 ABC transporter, permease HVX45_11130 ENOG4105DHJ ABC, transporter HVX45_11135 ENOG4105FEU K -dependent Na -Ca exchanger HVX45_11140 ENOG4105C2X Arabinose 5-phosphate isomerase HVX45_11150 ENOG4108P1K Required for the translocation of lipopolysaccharide (LPS) from the inner membrane to the outer membrane (By similarity) HVX45_11155 ENOG4105WI0 lipopolysaccharide transport periplasmic protein lptA HVX45_11160 ENOG4108IUZ ABC transporter HVX45_11165 ENOG4105DTW Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HVX45_11170 ENOG41080QH sigma 54 modulation protein ribosomal protein S30EA HVX45_11175 ENOG4107RM2 PTS IIA-like nitrogen-regulatory protein PtsN HVX45_11185 ENOG41080Z8 PHOSPHOCARRIER protein HVX45_11190 ENOG4108NIH transferase activity, transferring phosphorus-containing groups HVX45_11200 ENOG4108556 Isoprenoid biosynthesis protein with amidotransferase-like domain HVX45_11205 ENOG4105BZU Histidine kinase HVX45_11210 ENOG4105N5T Radical SAM Protein HVX45_11215 ENOG4105CBC glutamate synthase HVX45_11220 ENOG4105BZ8 glutamate synthase HVX45_11225 ENOG4105DFS Conserved Protein HVX45_11230 ENOG4108R66 Conserved Protein HVX45_11260 ENOG4105KB2 stringent starvation protein b HVX45_11265 ENOG4107MKT Stringent starvation protein a HVX45_11280 ENOG4105D6Z AFG1 family ATPase HVX45_11285 ENOG4108W2Q Cytochrome d ubiquinol oxidase subunit III HVX45_11290 ENOG4105C0H protease HVX45_11295 ENOG4105C0H protease HVX45_11305 ENOG4107GFK fumarate HVX45_11310 ENOG4106DSS Tartrate dehydratase subunit alpha HVX45_11315 ENOG4105C8P )-transporter HVX45_11325 ENOG4105G3Z GntR family transcriptional regulator HVX45_11340 ENOG4105RID UPF0379 protein yhcN HVX45_11345 ENOG4105UNR (Barnase) inhibitor HVX45_11360 ENOG4105ZQC membrane protein AaeX HVX45_11365 ENOG4105CR8 Transcriptional regulator HVX45_11370 ENOG4105D1U peptidase U62 modulator of DNA gyrase HVX45_11375 ENOG4105QD6 exported protein HVX45_11380 ENOG4105C03 ribonuclease HVX45_11390 ENOG4105VQ7 Rod shape-determining protein MreD HVX45_11395 ENOG4105N3I Involved in formation and maintenance of cell shape (By similarity) HVX45_11405 ENOG41062P1 Diguanylate cyclase phosphodiesterase HVX45_11410 ENOG4105D3Z quinone oxidoreductase, yhdh yhfp family HVX45_11425 ENOG4105KM4 Acetyl-CoA carboxylase, biotin carboxyl carrier protein HVX45_11430 ENOG4105CER acetyl-CoA carboxylase biotin carboxylase HVX45_11435 ENOG4105RG0 Membrane HVX45_11440 ENOG4108IA2 Sodium pantothenate symporter HVX45_11450 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) HVX45_11460 ENOG4105CEC DNA methylase N-4 N-6 HVX45_11465 ENOG41061ME transport protein HVX45_11470 ENOG4108XG4 DNA-binding transcriptional regulator HVX45_11475 ENOG4105C1P efflux transporter, rnd family, mfp subunit HVX45_11480 ENOG4105BZS acriflavin resistance protein HVX45_11485 ENOG4105XCM membrane LIPOPROTEIN HVX45_11495 ENOG4105EZ7 amino acid ABC transporter HVX45_11500 ENOG4105DRP amino acid AbC transporter HVX45_11505 ENOG4105CDA abc transporter atp-binding protein HVX45_11545 ENOG4108Z0R Transferase HVX45_11550 ENOG4105SG3 Protein of unknown function (DUF1488) HVX45_11565 ENOG4108WI1 Dna topoisomerase HVX45_11575 ENOG4105C79 DNA protecting protein DprA HVX45_11595 ENOG4105C1A potassium transporter peripheral membrane HVX45_11605 ENOG4105VCN Rescues the ribosomes stalled at the 3' end of non-stop mRNAs. May induce hydrolysis of the ribosome-bound peptidyl-tRNA. This activity is crucial when the stalled ribosome can not be rescued by the SsrA(tmRNA)-SmpB quality control system HVX45_11610 ENOG4105W1Y Transcriptional regulator HVX45_11615 ENOG4105VTS DnaJ-like, subfamily C HVX45_11645 ENOG41067V7 50S ribosomal protein L36 HVX45_11650 ENOG4105CGG The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity) HVX45_11695 ENOG4105KAR One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit (By similarity) HVX45_11740 ENOG41080KG One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity) HVX45_11765 ENOG4108UQY Iron-storage protein HVX45_11770 ENOG4105W53 bacterioferritin-associated ferredoxin HVX45_11810 ENOG4105WWK YheO domain protein HVX45_11815 ENOG4108V1T peptidylprolyl cis-trans isomerase HVX45_11825 ENOG4108YZY peptidylprolyl cis-trans isomerase HVX45_11830 ENOG4105VKU nucleicacid-binding protein HVX45_11845 ENOG4105C5H ABC transporter HVX45_11850 ENOG4105DNZ Alpha Beta Hydrolase HVX45_11860 ENOG4105CJE phosphoribulokinase (EC 2.7.1.19) HVX45_11865 ENOG4108UKZ OsmC family HVX45_11875 ENOG410613R integral membrane protein, YccS YhfK family HVX45_11880 ENOG4105C8Y Acetylornithine aminotransferase HVX45_11885 ENOG4105DDQ anthranilate synthase HVX45_11890 ENOG4105MZU cell filamentation protein HVX45_11900 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) HVX45_11905 ENOG4107QZF nitrite reductase NADPH large subunit HVX45_11910 ENOG4105WZK nitrite reductase NADPH small subunit HVX45_11915 ENOG4107V9H nitrite transporter HVX45_11925 ENOG4105VYH HVX45_11930 ENOG4106PKC pyridoxal phosphate binding HVX45_11935 ENOG4106M0N transport system permease protein HVX45_11940 ENOG4105MUZ Protein of unknown function DUF2620 HVX45_11945 ENOG41080QX K07048 phosphotriesterase-related protein HVX45_11950 ENOG4105CZG Phosphotransfer between the C1 and C5 carbon atoms of pentose (By similarity) HVX45_11955 ENOG4108626 Racemase HVX45_11960 ENOG4105RMW regulation of transcription, DNA-dependent HVX45_11965 ENOG4108M21 HVX45_11970 ENOG4105C31 Tryptophanyl-tRNA synthetase HVX45_11975 ENOG4108VXP Specifically catalyzes the dephosphorylation of 2- phosphoglycolate. Is involved in the dissimilation of the intracellular 2-phosphoglycolate formed during the DNA repair of 3'-phosphoglycolate ends, a major class of DNA lesions induced by oxidative stress (By similarity) HVX45_11980 ENOG4105DJV ribulose-phosphate 3-epimerase HVX45_11985 ENOG4105DFE Dna adenine methylase HVX45_11990 ENOG4105EGB membrane protein DamX HVX45_12005 ENOG4105E4G Type IV pilus HVX45_12010 ENOG4105ITY Required for the use of extracellular DNA as a nutrient HVX45_12015 ENOG4105XPX DNA utilization protein HofO HVX45_12020 ENOG41065NF Fimbrial assembly family protein HVX45_12025 ENOG4108U1Q Pilus assembly protein HVX45_12030 ENOG4108JQC penicillin-binding protein 1A HVX45_12035 ENOG4107RK2 ADP-ribose diphosphatase NudE HVX45_12040 ENOG4105DQY intracellular growth attenuator HVX45_12045 ENOG4107Y3D HAD-superfamily hydrolase subfamily IA variant 3 HVX45_12050 ENOG4105VEJ Heat shock protein HVX45_12060 ENOG4108MAJ Membrane HVX45_12085 ENOG4105E0F Histidine kinase HVX45_12095 ENOG4108RRZ Transcription elongation factor GreB HVX45_12100 ENOG4105BZM domain protein HVX45_12105 ENOG4105XFK Ferrous iron transport protein A HVX45_12110 ENOG4105CE1 Ferrous iron transport protein b HVX45_12120 ENOG4105DNE Transposase HVX45_12125 ENOG4105D3C The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters (By similarity) HVX45_12130 ENOG4105MJ2 Competence protein HVX45_12140 ENOG4105C6Z Gluconate HVX45_12150 ENOG4107RTM 4-alpha-glucanotransferase (EC 2.4.1.25) HVX45_12155 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) HVX45_12165 ENOG4105CKX Catalyzes the conversion of 3'-phosphate to a 2',3'- cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps (A) adenylation of the enzyme by ATP HVX45_12170 ENOG4105E0Y RtcB Protein HVX45_12175 ENOG4105CYB regulatoR HVX45_12180 ENOG4105E98 transcriptional regulator DeoR family HVX45_12195 ENOG4105C6V Glycerol-3-phosphate dehydrogenase HVX45_12210 ENOG4105CVA phosphate HVX45_12215 ENOG4105MHR Fimbrial protein HVX45_12220 ENOG4106PH7 chaperone HVX45_12230 ENOG4108WDE Fimbrial protein HVX45_12235 ENOG4105CW0 outer membrane usher protein HVX45_12240 ENOG4108NAE Fimbrial chaperone protein HVX45_12250 ENOG4107QQN Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties (By similarity) HVX45_12275 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) HVX45_12280 ENOG41076UM multiple antibiotic resistance (MarC)-related protein HVX45_12285 ENOG4105C6Z Gluconate HVX45_12290 ENOG4108Z67 carbohydrate kinase, thermoresistant glucokinase family HVX45_12295 ENOG4105DIQ Transcriptional regulator HVX45_12300 ENOG4105C2I pirin domain protein HVX45_12305 ENOG4105D9R oxidoreductase HVX45_12310 ENOG4105WCN acetyltransferase HVX45_12315 ENOG4105CFB Gamma-glutamyltranspeptidase (EC 2.3.2.2) HVX45_12320 ENOG4105WC8 Conserved Protein HVX45_12325 ENOG4107T6V glycerophosphoryl diester phosphodiesterase HVX45_12335 ENOG4105EX2 Binding-protein-dependent transport systems, inner membrane component HVX45_12340 ENOG4105E4X binding-protein-dependent transport systems inner membrane Component HVX45_12345 ENOG4105BZ7 extracellular solute-binding protein family 1 HVX45_12355 ENOG4108IV0 ABC, transporter HVX45_12360 ENOG4105C0Z ABC transporter HVX45_12365 ENOG4105CF8 branched-chain amino acid ABC transporter, permease HVX45_12370 ENOG4105C32 Amino acid ABC transporter (Permease) HVX45_12375 ENOG4105CP9 extracellular ligand-binding receptor HVX45_12380 ENOG4105U59 -acetyltransferase HVX45_12385 ENOG4105CP9 extracellular ligand-binding receptor HVX45_12390 ENOG4105DEK Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HVX45_12395 ENOG4105CRP Part of the ABC transporter FtsEX involved in HVX45_12400 ENOG4105CAK Cell division ATP-binding protein ftsE HVX45_12405 ENOG4105CCP Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC) HVX45_12410 ENOG4106H78 methyltransferase HVX45_12415 ENOG4105MG3 Membrane HVX45_12425 ENOG4107FS9 Membrane HVX45_12440 ENOG4105EX9 Membrane HVX45_12445 ENOG4108W1V Lipoprotein HVX45_12450 ENOG4105F9N Major Facilitator Superfamily HVX45_12455 ENOG4105DSF transport protein HVX45_12475 ENOG4105E9Q Acyl-transferase HVX45_12505 ENOG4106N3V dolichyl-phosphate beta-D-mannosyltransferase (EC 2.4.1.83) HVX45_12530 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) HVX45_12540 ENOG4105C2D reductase HVX45_12545 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) HVX45_12550 ENOG4107YAK holo-(acyl carrier protein) synthase 2 HVX45_12560 ENOG4105CMI transporter HVX45_12565 ENOG4105CJ1 ABC, transporter HVX45_12570 ENOG4105D0S secretion protein (HlyD HVX45_12575 ENOG4107UNS conserved inner membrane protein HVX45_12580 ENOG4105CYP glycoside hydrolase, family HVX45_12600 ENOG4105CBX hi0933 family HVX45_12605 ENOG4105CJ3 phosphate transporter HVX45_12620 ENOG4105DUX Transporter HVX45_12630 ENOG4105DGW oligopeptidase A HVX45_12635 ENOG4105D6S protein involved in catabolism of external DNA HVX45_12640 ENOG4105DC8 reductase HVX45_12650 ENOG4105KBH arsR family transcriptional regulator HVX45_12655 ENOG4107R5R arsenical pump membrane protein HVX45_12660 ENOG4105K89 arsenate reductase HVX45_12680 ENOG4106S2D Transcriptional regulator HVX45_12685 ENOG4107H3J ribonuclease HVX45_12690 ENOG4105CSH Transporter HVX45_12695 ENOG41066T0 asmA family HVX45_12700 ENOG4105CMB EAL domain-containing protein HVX45_12705 ENOG4107SS6 2-dehydro-3-deoxygluconokinase HVX45_12740 ENOG4105CS0 peptidase HVX45_12750 ENOG4105BZU Histidine kinase HVX45_12755 ENOG4105EJG cellulose synthase HVX45_12760 ENOG4105K2Z endo-1,4-d-glucanase (EC 3.2.1.4) HVX45_12765 ENOG4107EEX Cellulose synthase regulator protein HVX45_12780 ENOG410661M cytoplasmic protein HVX45_12785 ENOG4105U74 cellulose biosynthesis protein BcsE HVX45_12790 ENOG4105WQA Cellulose biosynthesis protein BcsF HVX45_12795 ENOG4105D1V cellulose synthase operon protein YhjU HVX45_12820 ENOG4105C28 cystathionine HVX45_12825 ENOG4105C44 Serine transporter HVX45_12835 ENOG4108JQ7 (ABC) transporter HVX45_12840 ENOG4105C3U ABC transporter HVX45_12845 ENOG4105C2T Binding-protein-dependent transport systems, inner membrane component HVX45_12850 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HVX45_12855 ENOG4105DEF Extracellular solute-binding protein, family 5 HVX45_12870 ENOG4105DIJ Phosphoethanolamine transferase HVX45_12875 ENOG4105FCD Major Facilitator HVX45_12880 ENOG4105EAX Putative lipase HVX45_12885 ENOG4108R3E Dna-3-methyladenine glycosylase i HVX45_12890 ENOG4105HNP -acetyltransferase HVX45_12895 ENOG4107QY8 reductase HVX45_12900 ENOG4108ZG0 Ompa motb domain protein HVX45_12905 ENOG4108M60 Transcriptional regulator HVX45_12915 ENOG4105D7K pfkb domain protein HVX45_12930 ENOG4106JH6 (LipO)protein HVX45_12935 ENOG4105D2S major facilitator superfamily HVX45_12940 ENOG4105MVF Transcriptional regulator HVX45_12980 ENOG4105MEV Acyl-transferase HVX45_12985 ENOG410688U Inner membrane protein yiaB HVX45_12990 ENOG4105CMG Carbohydrate kinase HVX45_13000 ENOG4105T16 Transcriptional regulator (AraC family) HVX45_13005 ENOG4108UR8 BAX protein HVX45_13010 ENOG4107T9C Alpha amylase catalytic region HVX45_13015 ENOG4105JKW Valine--pyruvate aminotransferase HVX45_13020 ENOG4108XIB electron transport protein ysaA HVX45_13025 ENOG4105J4Q Transcriptional regulator HVX45_13035 ENOG4108R66 Conserved Protein HVX45_13040 ENOG4105XDZ Tripartite ATP-independent periplasmic transporter HVX45_13045 ENOG4105CG6 trap dicarboxylate transporter dctm subunit HVX45_13050 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit HVX45_13055 ENOG4105CMG Carbohydrate kinase HVX45_13060 ENOG4105H6Q decarboxylase HVX45_13065 ENOG41064BZ L-xylulose 5-phosphate 3-epimerase HVX45_13070 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase HVX45_13075 ENOG4105C26 Dehydrogenase HVX45_13080 ENOG4105C0A alcohol dehydrogenase HVX45_13085 ENOG4105EM7 Selenocysteine-specific translation elongation factor HVX45_13095 ENOG4108U78 Glutathione S-transferase HVX45_13100 ENOG4105EFX secretion protein, HlyD family HVX45_13105 ENOG4105FP6 Protein of unknown function (DUF3302) HVX45_13110 ENOG4105CTS PTS system mannitol-specific HVX45_13120 ENOG4105E61 Mannitol repressor protein HVX45_13130 ENOG4108YYI Protein of unknown function (DUF2810) HVX45_13135 ENOG4108WY4 inner membrane lipoprotein HVX45_13140 ENOG4105EUR Domain-Containing protein HVX45_13145 ENOG4105DAA L-lactate HVX45_13150 ENOG41073TP transcriptional regulator HVX45_13160 ENOG4108UIQ Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity) HVX45_13165 ENOG4105D7W serine acetyltransferase HVX45_13180 ENOG4105VW4 glutaredoxin 3 HVX45_13185 ENOG4107YZP Rhodanese domain protein HVX45_13195 ENOG41063SB peptidase HVX45_13200 ENOG4105PXI polysaccharide deacetylase HVX45_13205 ENOG4105K64 Glycosyl transferase, family 2 HVX45_13210 ENOG4105D4P Coproporphyrinogen iii oxidase HVX45_13215 ENOG4105ZR3 A GTPase-activating protein (GAP) that modifies Der EngA GTPase function. May play a role in ribosome biogenesis (By similarity) HVX45_13230 ENOG4105C2M dna polymerase I HVX45_13235 ENOG4106HNH Acyl-transferase HVX45_13245 ENOG4108Z33 Thiol disulfide Interchange Protein HVX45_13250 ENOG4105E27 serine threonine protein kinase HVX45_13255 ENOG4105PC1 Conserved Protein HVX45_13260 ENOG4105C6R Transfers a GMP moiety from GTP to Mo-molybdopterin (Mo- MPT) cofactor (Moco or molybdenum cofactor) to form Mo- molybdopterin guanine dinucleotide (Mo-MGD) cofactor (By similarity) HVX45_13265 ENOG4105FNP Molybdopterin-guanine dinucleotide biosynthesis protein b HVX45_13295 ENOG4108RR8 protoporphyrinogen oxidase HVX45_13300 ENOG4105D37 Low-affinity potassium transport system. Interacts with Trk system potassium uptake protein TrkA (By similarity) HVX45_13305 ENOG4108ZK7 protein family UPF0029, Impact, N-terminal protein HVX45_13315 ENOG4105DYT 3-hydroxyacyl-CoA dehydrogenase HVX45_13325 ENOG4108MR7 Arylsulfotransferase HVX45_13330 ENOG4108EX3 reductase HVX45_13335 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) HVX45_13340 ENOG4105MDZ Transcriptional activator rfaH HVX45_13350 ENOG4105DCX Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides (By similarity) HVX45_13355 ENOG4105X8U Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation (By similarity) HVX45_13360 ENOG4105WKS Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system (By similarity) HVX45_13370 ENOG4105JC1 sterol-binding domain protein HVX45_13380 ENOG4105CGY Dna recombination protein HVX45_13385 ENOG4107HP6 Transcriptional regulator HVX45_13390 ENOG4105EI3 2-dehydro-3-deoxygalactonokinase EC 2.7.1.58 HVX45_13395 ENOG4108RTU Aldolase HVX45_13400 ENOG4105JN3 extra-cytoplasmic solute receptor family protein HVX45_13415 ENOG4108I5U Uridine phosphorylase HVX45_13420 ENOG4105CDZ Carboxymethylenebutenolidase (EC 3.1.1.45) HVX45_13425 ENOG4106XMA In vivo, quickly hydrolyzes the ureidoacrylate peracid to avoid toxicity, but can also hydrolyzes ureidoacrylate that is formed spontaneously from ureidoacrylate peracid. One of the products of hydrolysis, carbamate, hydrolyzes spontaneously, thereby releasing one of the pyrimidine rings nitrogen atoms as ammonia and one of its carbons as CO2 (By similarity) HVX45_13435 ENOG4107R1Q Membrane protein FdrA HVX45_13440 ENOG4107REC cytoplasmic protein HVX45_13445 ENOG4105C5B carbamate kinase HVX45_13455 ENOG4105DQW permease for cytosine purines, uracil, thiamine, allantoin HVX45_13460 ENOG4105F52 Transcriptional regulator HVX45_13470 ENOG4105DSS Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation (By similarity) HVX45_13475 ENOG4105DZ2 Transcriptional regulator HVX45_13480 ENOG4105EMK carboxylate amino acid amine transporter HVX45_13485 ENOG4105DQF Hydrolase HVX45_13490 ENOG4108EUD Lysophospholipase HVX45_13495 ENOG410829K Lysine exporter protein (Lyse ygga) HVX45_13500 ENOG4105CCF Lysine exporter protein (Lyse ygga) HVX45_13505 ENOG4105C9U ATP-dependent DNA helicase RecQ HVX45_13515 ENOG4105HDD phospholipase HVX45_13520 ENOG4108VUY thioesterase Superfamily protein HVX45_13525 ENOG4105FR1 rard protein HVX45_13535 ENOG4107QUT magnesium and cobalt transport protein CorA HVX45_13540 ENOG4107V4F S-adenosyl-l-methionine hydroxide adenosyltransferase HVX45_13545 ENOG4105C4R Atp-dependent dna helicase HVX45_13550 ENOG4105DFC had-superfamily hydrolase, subfamily ia, variant HVX45_13560 ENOG4105CT0 Protein of unknown function, DUF484 HVX45_13570 ENOG4105S7Z (LipO)protein HVX45_13590 ENOG4107T0K Adenylate cyclase HVX45_13600 ENOG41076E6 Uroporphyrinogen-III Synthase HVX45_13605 ENOG4105ECF c-methyltransferase HVX45_13610 ENOG410601J HemY protein HVX45_13620 ENOG4105ENH Sulfatase HVX45_13625 ENOG4105C4X radical SAM domain protein HVX45_13650 ENOG4105C85 amino acid HVX45_13670 ENOG4105EGZ biosynthesis protein HVX45_13675 ENOG4105CF4 DegT DnrJ EryC1 StrS aminotransferase HVX45_13680 ENOG4108WJ1 acetyltransferase HVX45_13685 ENOG4108I19 Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis (By similarity) HVX45_13690 ENOG4105C1B dTDP-glucose 4-6-dehydratase HVX45_13695 ENOG4107QQG Dehydrogenase HVX45_13700 ENOG4105EAG UDP-N-acetylglucosamine 2-epimerase HVX45_13705 ENOG4105SFE lipopolysaccharide biosynthesis protein HVX45_13710 ENOG4105ESV Glycosyl transferase, family 4 HVX45_13715 ENOG4105C4P Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template (By similarity) HVX45_13740 ENOG4105C4R Atp-dependent dna helicase HVX45_13745 ENOG4105KQ5 peptidylprolyl cis-trans isomerase HVX45_13755 ENOG4105EMY transcriptional regulator HVX45_13760 ENOG4105C7B Threonine dehydratase HVX45_13770 ENOG4105CM2 brancheD-chain amino acid aminotransferase HVX45_13775 ENOG4105P3Y Acetolactate synthase 2 regulatory subunit HVX45_13795 ENOG4105C0P Mg chelatase subunit ChlI HVX45_13800 ENOG4108WFC UPF0438 protein yifE HVX45_13840 ENOG4107EJG GntR family transcriptional regulator HVX45_13845 ENOG4105ETE Transcriptional regulator (LacI family HVX45_13850 ENOG4108RVA ribokinase HVX45_13855 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator HVX45_13860 ENOG4105CNN ABC, transporter HVX45_13865 ENOG4105C2J ABC transporter HVX45_13895 ENOG4108VVK transcriptional Regulator, AsnC HVX45_13900 ENOG4105QTB Flavodoxin HVX45_13915 ENOG4105GXX Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit I associates with the membrane and may be involved with cation translocation HVX45_13970 ENOG4105C46 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity) HVX45_13975 ENOG4107QMV Part of the ABC transporter complex PstSACB involved in phosphate import (By similarity) HVX45_13980 ENOG4105C8U phosphate abc transporter HVX45_13985 ENOG4105E2Z phosphate ABC transporter (Permease HVX45_13990 ENOG4105BZY Part of the ABC transporter complex PstSACB involved in phosphate import. Responsible for energy coupling to the transport system (By similarity) HVX45_13995 ENOG4108UTW Plays a role in the regulation of phosphate uptake HVX45_14000 ENOG4105CID antiterminator HVX45_14005 ENOG4105C5Y PTS System HVX45_14010 ENOG4105CS2 ec 3.2.1.21 HVX45_14020 ENOG4105DYC esterase HVX45_14025 ENOG4107VKM 6-phosphogluconolactonase HVX45_14030 ENOG4106611 bacteriocin immunity HVX45_14040 ENOG4107UB3 HAD-superfamily hydrolase subfamily IA variant 3 HVX45_14045 ENOG4105C7N Xanthine uracil vitamin C permease HVX45_14055 ENOG4108YYH Nadph-dependent fmn reductase HVX45_14060 ENOG4105E8Q phosphopantetheinyl transferase HVX45_14075 ENOG4108P6C Tryptophan transporter of low affinity HVX45_14110 ENOG4105VG0 50S ribosomal protein l34 HVX45_14125 ENOG4105CZ8 DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity) HVX45_14135 ENOG4105C7D DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HVX45_14140 ENOG4105VP5 Bacterial protein of unknown function (DUF937) HVX45_14145 ENOG410667J hydrolase HVX45_14150 ENOG410657R replicase EC 2.7 HVX45_14155 ENOG4105EMF GntR family transcriptional regulator HVX45_14160 ENOG4105EI3 2-dehydro-3-deoxygalactonokinase EC 2.7.1.58 HVX45_14165 ENOG4108RTU Aldolase HVX45_14175 ENOG4105DJB Major Facilitator Superfamily HVX45_14185 ENOG4105D99 atp gtp-binding protein HVX45_14190 ENOG4105R2A (LipO)protein HVX45_14200 ENOG4108SHS Associates with aggregated proteins, together with IbpA, to stabilize and protect them from irreversible denaturation and extensive proteolysis during heat shock and oxidative stress. Aggregated proteins bound to the IbpAB complex are more efficiently refolded and reactivated by the ATP-dependent chaperone systems ClpB and DnaK DnaJ GrpE. Its activity is ATP- independent (By similarity) HVX45_14205 ENOG4105D0C transport protein HVX45_14210 ENOG4105FDP GntR family transcriptional regulator HVX45_14215 ENOG4105CI1 PTS System HVX45_14220 ENOG4105F8D glycoside hydrolase family 4 HVX45_14225 ENOG4108AHD Transcriptional regulator HVX45_14230 ENOG4107RUZ Sss sodium solute transporter superfamily HVX45_14235 ENOG4105CBG Sulfatase HVX45_14240 ENOG4106DRA Inner membrane protein YidI HVX45_14245 ENOG4105VG5 Membrane HVX45_14250 ENOG4105JP4 Inner membrane protein yidG HVX45_14255 ENOG4105J13 transcriptional regulator HVX45_14260 ENOG4105E5M Multidrug resistance protein D HVX45_14275 ENOG4105C7K acetolactate synthase HVX45_14280 ENOG4105M71 acetolactate synthase 1 regulatory subunit HVX45_14285 ENOG4108KX4 response regulator HVX45_14290 ENOG4105BZU Histidine kinase HVX45_14295 ENOG4105CXY transporter HVX45_14300 ENOG4105CXY transporter HVX45_14310 ENOG4108SAJ Protein of unknown function (DUF1198) HVX45_14320 ENOG4105VCP PTS System HVX45_14325 ENOG4105CS2 ec 3.2.1.21 HVX45_14330 ENOG4105CK1 PTS System HVX45_14340 ENOG4105ETE Transcriptional regulator (LacI family HVX45_14345 ENOG4105T8A Uncharacterized protein YicS HVX45_14350 ENOG4108UZ3 Transporter HVX45_14420 ENOG4105DFP Integrase HVX45_14430 ENOG4105CT4 transporter HVX45_14435 ENOG4105CJQ hydrolase, family 31 HVX45_14440 ENOG4105JV1 AsmA family HVX45_14445 ENOG4105C2W permease HVX45_14450 ENOG4105D6U Sodium Glutamate Symporter HVX45_14460 ENOG4105CB5 ATP-dependent DNA helicase recG HVX45_14465 ENOG4105FE8 tRNA (Guanosine-2'-O-)-methyltransferase HVX45_14470 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) HVX45_14480 ENOG4108UHA Essential for recycling GMP and indirectly, cGMP (By similarity) HVX45_14490 ENOG4105EN6 Membrane HVX45_14495 ENOG4105DSJ YicC domain protein HVX45_14510 ENOG4107RRE RNA-directed DNA polymerase HVX45_14520 ENOG4108Z1K This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity) HVX45_14525 ENOG4105CJS Phosphopantothenoylcysteine decarboxylase HVX45_14535 ENOG4105KDC 50s ribosomal protein l28 HVX45_14555 ENOG4105D8A 3-Deoxy-D-manno-octulosonic-acid transferase HVX45_14560 ENOG4105DKP glycosyl transferase, family 9 HVX45_14565 ENOG4107RJ7 Glycosyl transferase (Group 1 HVX45_14570 ENOG4107543 (lipo)polysaccharide HVX45_14575 ENOG410650X lipopolysaccharide core region biosynthetic process HVX45_14580 ENOG4107XU6 Glycosyl transferase (Group 1 HVX45_14585 ENOG4106AH0 Glycosyl Transferase HVX45_14590 ENOG4105X1N Glycosyl transferase family 8 HVX45_14595 ENOG4108PDR lipopolysaccharide core biosynthesis protein HVX45_14600 ENOG4108QD8 lipopolysaccharide core biosynthesis protein HVX45_14605 ENOG4107XB0 Lipopolysaccharide 1,2-N-acetylglucosaminetransferase HVX45_14610 ENOG4108FRV O-antigen ligase HVX45_14615 ENOG4105D16 lipopolysaccharide heptosyltransferase i HVX45_14620 ENOG4105XA0 heptosyltransferase ii HVX45_14630 ENOG4107EEK Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity) HVX45_14640 ENOG4106FIY HVX45_14645 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family HVX45_14650 ENOG4105CUX Signal transduction histidine kinase HVX45_14655 ENOG4105C5F glutamine synthetase HVX45_14660 ENOG4105CI3 gtp-binding protein typa HVX45_14665 ENOG4108KP7 hydrolase HVX45_14675 ENOG4105CSA Coproporphyrinogen iii oxidase HVX45_14695 ENOG4105EJU HAD-superfamily hydrolase subfamily IA variant 3 HVX45_14710 ENOG4105SUU thioesterase domain HVX45_14725 ENOG4108MG3 formate dehydrogenase HVX45_14730 ENOG4105QA4 4Fe-4S Ferredoxin, iron-sulfur binding domain protein HVX45_14745 ENOG4105CJX Molecular chaperone. Has ATPase activity (By similarity) HVX45_14755 ENOG4108V87 frv operon regulatory protein HVX45_14760 ENOG4106C3V frv operon regulatory protein HVX45_14765 ENOG4105CN9 Peptidase m42 family protein HVX45_14770 ENOG4105DM4 PTS System HVX45_14775 ENOG41064BA PTS system, fructose-specific, IIA component HVX45_14785 ENOG4105C0A alcohol dehydrogenase HVX45_14810 ENOG4108BRW Activates expression of the rhaSR operon in response to L-rhamnose (By similarity) HVX45_14820 ENOG4105CK4 Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity) HVX45_14825 ENOG4108RPX mosc domain containing protein HVX45_14830 ENOG4105E0F Histidine kinase HVX45_14835 ENOG4105E3W Two component transcriptional regulator (Winged helix family HVX45_14840 ENOG4105FMW periplasmic HVX45_14855 ENOG4105DE7 Sulfate ABC transporter periplasmic sulfate-binding protein HVX45_14870 ENOG4105EBK exported protein HVX45_14875 ENOG4108VTS Membrane HVX45_14880 ENOG41065TG regulatoR HVX45_14890 ENOG4105DP0 ferredoxin-NADP reductase HVX45_14895 ENOG4105CBT Fructose-1,6-bisphosphatase HVX45_14905 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) HVX45_14920 ENOG4105EIS 1,4-dihydroxy-2-naphthoate octaprenyltransferase HVX45_14935 ENOG41063M6 Cell Division Protein HVX45_14940 ENOG4105ETE Transcriptional regulator (LacI family HVX45_14945 ENOG4105C25 Primosomal protein n' HVX45_14960 ENOG4107S01 Repressor protein MetJ HVX45_14970 ENOG4105C28 cystathionine HVX45_14975 ENOG4105CFH Aspartokinase HVX45_14985 ENOG4105CGH 5'-nucleotidase HVX45_14990 ENOG4105SYT Methylenetetrahydrofolate reductase HVX45_15000 ENOG4108Q5Y Membrane HVX45_15005 ENOG4108XC3 NADH ubiquinone oxidoreductase HVX45_15010 ENOG4105DCT glycerol dehydrogenase HVX45_15015 ENOG4107T9Z Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) HVX45_15020 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) HVX45_15025 ENOG4105DM4 PTS System HVX45_15030 ENOG4108YRF PTS System HVX45_15040 ENOG4108AHH pyruvate formate lyase II activase HVX45_15045 ENOG4108XCZ PTS System HVX45_15050 ENOG4106R3P AraC family transcriptional regulator HVX45_15055 ENOG4105DIJ Phosphoethanolamine transferase HVX45_15070 ENOG4105C0N N-acetylglutamate semialdehyde dehydrogenase HVX45_15085 ENOG4105C5Q Transcriptional regulator HVX45_15095 ENOG4105CH2 amidohydrolase HVX45_15105 ENOG4105EJ2 Transcriptional regulator HVX45_15110 ENOG4108Y73 Membrane HVX45_15120 ENOG4105CHI Involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space. It derives its energy for transport by interacting with the trans-periplasmic membrane protein TonB (By similarity) HVX45_15150 ENOG4105D4A Cell wall formation (By similarity) HVX45_15155 ENOG4105HJX Biotin- acetyl-CoA-carboxylase ligase HVX45_15190 ENOG4105PM1 preprotein translocase subunit SecE HVX45_15195 ENOG4105E5V Participates in transcription elongation, termination and antitermination (By similarity) HVX45_15230 ENOG4105D41 biosynthesis protein thiH HVX45_15240 ENOG4105WHD thiamine biosynthesis protein ThiS HVX45_15245 ENOG4105D06 uba thif-type nad fad binding protein HVX45_15280 ENOG4105R2J Conserved Protein HVX45_15290 ENOG4108T8B Protein of unknown function (DUF1481) HVX45_15295 ENOG4105JBU Binds zinc. Could be an important component of the zinc- balancing mechanism HVX45_15300 ENOG4105BZU Histidine kinase HVX45_15305 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family HVX45_15310 ENOG4105C12 Phosphoribosylglycinamide synthetase HVX45_15340 ENOG4105K5X acetyltransferase HVX45_15350 ENOG4107QP3 malate synthase g HVX45_15355 ENOG4108I9X Isocitrate lyase HVX45_15370 ENOG41069M3 Transcriptional regulator HVX45_15375 ENOG4105C3R Methionine synthase HVX45_15390 ENOG4105EAM Na Pi-cotransporter HVX45_15395 ENOG4105IUQ nucleoprotein polynucleotide-associated enzyme HVX45_15400 ENOG4105DXH Alcohol dehydrogenase zinc-binding domain protein HVX45_15405 ENOG4105F3R pts system mannose fructose sorbose family iid HVX45_15410 ENOG4105ETZ PTS System HVX45_15415 ENOG4105KPI PTS system sorbose subfamily IIB component HVX45_15420 ENOG4108XCU pts system HVX45_15425 ENOG4105CHR reductase HVX45_15430 ENOG4105DKT Transcriptional regulator HVX45_15435 ENOG4105FE9 pseudouridine synthase HVX45_15440 ENOG4108ZR5 Conserved Protein HVX45_15450 ENOG410756H nucleotidyltransferase HVX45_15470 ENOG410685N tail fiber protein HVX45_15550 ENOG4107SC1 transglycosylase HVX45_15570 ENOG4105CFH Aspartokinase HVX45_15575 ENOG4107QP8 phosphohexose isomerase HVX45_15585 ENOG4108MDC (LipO)protein HVX45_15590 ENOG4108Q9C Periplasmic Protein HVX45_15595 ENOG4105E3R (LipO)protein HVX45_15610 ENOG4105EG2 ABC transporter, permease HVX45_15615 ENOG4105D56 permease protein HVX45_15620 ENOG4107FKK extracellular solute-binding protein family 1 HVX45_15625 ENOG4108IJ9 (ABC) transporter HVX45_15635 ENOG4107W52 maltose operon periplasmic protein HVX45_15655 ENOG41080IJ Diacylglycerol kinase HVX45_15665 ENOG4107R73 Mate efflux family protein HVX45_15670 ENOG4105VDW Csbd family HVX45_15675 ENOG4105MYN Zinc uptake regulation protein HVX45_15680 ENOG4105CEH Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity) HVX45_15685 ENOG4105P4Z Phage shock protein G HVX45_15690 ENOG4105EE6 Alcohol dehydrogenase zinc-binding domain protein HVX45_15695 ENOG4105CDU Replicative dna helicase HVX45_15710 ENOG4105CJ4 Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity) HVX45_15715 ENOG4106Z1T Nicotinamide Mononucleotide Transporter HVX45_15720 ENOG4107VZS Nicotinamide-nucleotide adenylyltransferase HVX45_15725 ENOG4105CGF Aromatic amino acid aminotransferase HVX45_15730 ENOG4105C7P 2-oxoglutarate dehydrogenase, E1 HVX45_15735 ENOG4105C7S Dehydrogenase HVX45_15740 ENOG4107QN2 dihydrolipoyl dehydrogenase HVX45_15745 ENOG4105CMV Succinyl-CoA synthetase subunit beta HVX45_15750 ENOG4105CH8 Succinyl-CoA ligase ADP-forming subunit alpha HVX45_15755 ENOG4107QPK )-transporter HVX45_15760 ENOG4105DG4 malate L-lactate dehydrogenase HVX45_15770 ENOG4105CQZ Histidine kinase HVX45_15775 ENOG4105F0S class B acid phosphatase HVX45_15780 ENOG4108YXI Secondary thiamine-phosphate synthase enzyme HVX45_15785 ENOG4105MSB protein, conserved in bacteria HVX45_15790 ENOG4105C5U The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity) HVX45_15795 ENOG4108UUM single-stranded DNA-binding protein HVX45_15800 ENOG4105PMV Membrane HVX45_15805 ENOG4108W3Q Transcriptional regulator HVX45_15810 ENOG4108Z4X TRANSCRIPTIONal HVX45_15815 ENOG4105C7N Xanthine uracil vitamin C permease HVX45_15820 ENOG4105EEQ Na H antiporter HVX45_15825 ENOG4108Z8G Alkylphosphonate utilization operon protein PhnA HVX45_15830 ENOG4108F5E vimentin HVX45_15835 ENOG4108YIV HVX45_15840 ENOG4105CSH Transporter HVX45_15845 ENOG4105ECM Sensor protein basS pmrB HVX45_15850 ENOG4105XJC Two component transcriptional regulator (Winged helix family HVX45_15855 ENOG4105DIJ Phosphoethanolamine transferase HVX45_15860 ENOG4106ZGR Transcriptional regulator HVX45_15865 ENOG4108R5S membrane HVX45_15870 ENOG4107GFK fumarate HVX45_15875 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter HVX45_15880 ENOG4108MRH transcriptional regulatory protein HVX45_15885 ENOG4105CEQ signal transduction histidine kinase regulating citrate malate metabolism HVX45_15890 ENOG4107QY8 reductase HVX45_15895 ENOG4105QAX Iron-sulfur HVX45_15900 ENOG4107KGK dmso reductase anchor subunit HVX45_15905 ENOG4108NEM leader-binding protein dmsD HVX45_15925 ENOG4108SIC Transcriptional regulator HVX45_15930 ENOG4105CSG Required to facilitate the formation of correct disulfide bonds in some periplasmic proteins and for the assembly of the periplasmic c-type cytochromes. Acts by transferring electrons from cytoplasmic thioredoxin to the periplasm. This transfer involves a cascade of disulfide bond formation and reduction steps (By similarity) HVX45_15940 ENOG4105DS2 Anaerobic c4-dicarboxylate transporter HVX45_15945 ENOG4108IJ0 Aspartate ammonia-lyase HVX45_15950 ENOG4108YH1 overproduction of this protein in Escherichia coli inhibits the F plasmid-mediated exclusion of bacteriophage T7 HVX45_15955 ENOG4105DVH amino acid HVX45_15970 ENOG4108ZVF (LipO)protein HVX45_15975 ENOG4105MTB Uncharacterized protein YjeJ HVX45_15980 ENOG4105CK3 Lysine 2,3-aminomutase YodO family protein HVX45_15990 ENOG4107PEH Entericidin EcnA/B family HVX45_15995 ENOG4106BSU Entericidin B HVX45_16000 ENOG4105KPY Small multidrug resistance protein HVX45_16005 ENOG4105QNF Outer membrane lipoprotein HVX45_16010 ENOG41066YJ Beta-lactamase HVX45_16025 ENOG4105E33 succinate dehydrogenase HVX45_16030 ENOG4105C00 Succinate dehydrogenase (Flavoprotein subunit) HVX45_16045 ENOG4106CG8 Inner membrane protein YjeO HVX45_16050 ENOG4105EGS Mechanosensitive ion channel HVX45_16070 ENOG4106TNF Periplasmic binding protein HVX45_16095 ENOG4105EH2 Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity) HVX45_16100 ENOG4105DR1 Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity) HVX45_16105 ENOG4105K8N protein family UPF0079, ATPase HVX45_16110 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase HVX45_16130 ENOG4105C1N GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity) HVX45_16135 ENOG4107QJR hflk protein HVX45_16140 ENOG4105EPW hflc protein HVX45_16160 ENOG4105C40 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity) HVX45_16165 ENOG4105C2N RNA methyltransferase TrmH family group 3 HVX45_16170 ENOG4105FUX Conserved Protein HVX45_16175 ENOG4108P9J Phage shock protein A HVX45_16180 ENOG4107VNS Protein of unknown function (DUF2491) HVX45_16185 ENOG4105Z6B inner membrane protein yjfl HVX45_16190 ENOG4108KXT Conserved Protein HVX45_16195 ENOG4106032 Glutathionylspermidine synthase HVX45_16200 ENOG4105CSU acyl-Coa dehydrogenase HVX45_16205 ENOG4105S17 UPF0379 protein yjfN HVX45_16210 ENOG4105WSB biofilm stress and motility protein A HVX45_16215 ENOG4108MXZ Esterase HVX45_16220 ENOG4105DW5 Transcriptional regulator HVX45_16230 ENOG4105CZC PTS system ascorbate-specific transporter subunit IIC HVX45_16235 ENOG410907W The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is involved in ascorbate transport HVX45_16260 ENOG4105KIT UPF0379 protein yjfY HVX45_16275 ENOG4105VH8 Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity) HVX45_16285 ENOG4105DR6 Trap dicarboxylate transporter, dctp subunit HVX45_16290 ENOG4105CG6 trap dicarboxylate transporter dctm subunit HVX45_16295 ENOG41069H7 transport system small permease component HVX45_16300 ENOG4107S3R L-aspartate oxidase HVX45_16305 ENOG4107R0K CoA transferase having broad substrate specificity for short-chain acyl-CoA thioesters with the activity decreasing when the length of the carboxylic acid chain exceeds four carbons (By similarity) HVX45_16310 ENOG4105E39 Enoyl-CoA hydratase HVX45_16320 ENOG4105CHR reductase HVX45_16330 ENOG4105FHY Opacity-associated protein A HVX45_16335 ENOG4108V1T peptidylprolyl cis-trans isomerase HVX45_16350 ENOG4105DXC membrane HVX45_16355 ENOG4105ECR NmrA family HVX45_16360 ENOG4105KVH Transcriptional regulator HVX45_16365 ENOG4107RNS bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase 3'-nucleotidase periplasmic HVX45_16370 ENOG4108RNI 3'(2')5'-bisphosphate nucleotidase HVX45_16375 ENOG4108UUE Transcriptional regulator HVX45_16380 ENOG41061GZ Protein of unknown function (DUF1107) HVX45_16385 ENOG4105C37 (CBS) domain HVX45_16390 ENOG4108SQ4 Glyoxalase Bleomycin resistance protein (Dioxygenase HVX45_16400 ENOG4108YZG isomerase HVX45_16405 ENOG4105NYY transcriptional regulator, RpiR HVX45_16410 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator HVX45_16415 ENOG4105C2J ABC transporter HVX45_16420 ENOG4105CNN ABC, transporter HVX45_16425 ENOG4105UP7 3-epimerase HVX45_16430 ENOG4107TFG D-allose kinase HVX45_16435 ENOG4105EUZ Beta-lactamase domain protein HVX45_16445 ENOG4105J12 Multidrug resistance protein mdtN HVX45_16450 ENOG4108MI0 Resistance protein HVX45_16455 ENOG4105ETP RND efflux system, outer membrane lipoprotein HVX45_16465 ENOG41082ND Uncharacterized protein yjcO HVX45_16470 ENOG4105CK2 sodium dicarboxylate symporter HVX45_16475 ENOG4108W0S formate-dependent nitrite reductase complex HVX45_16485 ENOG4108QKW cytochrome c-type biogenesis protein HVX45_16490 ENOG4105DVI reductase, NrfD HVX45_16495 ENOG4105D3S 4Fe-4S Ferredoxin, iron-sulfur binding domain protein HVX45_16500 ENOG4105JJ8 Cytochrome c nitrite reductase, pentaheme subunit HVX45_16510 ENOG4108IQF Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA (By similarity) HVX45_16515 ENOG41062QD Membrane HVX45_16530 ENOG4105CFU surface antigen HVX45_16535 ENOG4105MA0 exported protein HVX45_16540 ENOG4108ZHD aig2 family HVX45_16545 ENOG4105F0N pyrophosphate phospho-hydrolase HVX45_16550 ENOG4107R5U Periplasmic binding protein LacI transcriptional regulator HVX45_16555 ENOG4105C2J ABC transporter HVX45_16560 ENOG4107R9N ABC transporter HVX45_16565 ENOG41062B0 ABC transporter, permease HVX45_16575 ENOG4105DFU Cell wall formation (By similarity) HVX45_16585 ENOG4105CMS peptidase U62, modulator of DNA gyrase HVX45_16590 ENOG4108XVM Cytochrome b(562) HVX45_16600 ENOG4105K4U addiction module toxin, RelE StbE family HVX45_16605 ENOG4108RDD Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine (By similarity) HVX45_16610 ENOG4105CJD (Anaerobic) ribonucleoside-triphosphate reductase HVX45_16615 ENOG4105CG3 alpha amylase, catalytic region HVX45_16620 ENOG4105C5Y PTS System HVX45_16625 ENOG4105D4X repressor HVX45_16635 ENOG4105KME endoribonuclease L-psp HVX45_16650 ENOG4107C93 pyrBI operon leader peptide HVX45_16660 ENOG4105CSX c4-dicarboxylate anaerobic carrier HVX45_16665 ENOG4105DBV ornithine carbamoyltransferase HVX45_16680 ENOG4105XEP YhcH YjgK YiaL family protein HVX45_16685 ENOG4105DBV ornithine carbamoyltransferase HVX45_16690 ENOG4105KQT Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome (By similarity) HVX45_16695 ENOG4108MJ3 acetyltransferase HVX45_16700 ENOG4108M3P Membrane HVX45_16705 ENOG4105CA4 amino acids such as threonine, to avoid such errors, it has a posttransfer editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner (By similarity) HVX45_16710 ENOG4105MYG DNA polymerase iii, chi subunit HVX45_16720 ENOG4108M8S permease YjgP YjgQ family protein HVX45_16725 ENOG4108K5H permease YjgP YjgQ family protein HVX45_16730 ENOG4105W4M Transport-associated protein HVX45_16750 ENOG4105CU0 Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity) HVX45_16760 ENOG4107WTH Galactitol-1-phosphate dehydrogenase HVX45_16765 ENOG4105DT3 PTS system, galactitol-specific IIc component HVX45_16770 ENOG41090UW PTS System HVX45_16775 ENOG41082GB PTS system galactitol-specific transporter subunit IIA HVX45_16785 ENOG4105DTZ bifunctional PTS system fructose-specific transporter subunit IIA HPr protein HVX45_16790 ENOG4105DM4 PTS System HVX45_16795 ENOG4106VEM tagatose-6-phosphate kinase HVX45_16800 ENOG4105D2N Aldolase HVX45_16805 ENOG4105MVE transcriptional regulator HVX45_16810 ENOG4107UEK pfkb domain protein HVX45_16815 ENOG4105CTX dehydratase HVX45_16825 ENOG4105CF3 3-Hydroxyisobutyrate dehydrogenase HVX45_16835 ENOG4108CNN domain protein HVX45_16840 ENOG4105CWB LysR family transcriptional Regulator HVX45_16845 ENOG4105KAF membrAne HVX45_16850 ENOG4105CHF Glutathione S-transferase HVX45_16855 ENOG4108VBZ doxx family HVX45_16860 ENOG4105YJD HVX45_16865 ENOG41090KG Inner membrane protein YqjE HVX45_16870 ENOG4105NE1 Conserved Protein HVX45_16875 ENOG4105WAY exported protein HVX45_16885 ENOG4106W5V Membrane HVX45_16890 ENOG4107YCY Transcriptional regulator HVX45_16895 ENOG4105DPW Major facilitator superfamily MFS_1 HVX45_16905 ENOG4105CTX dehydratase HVX45_16910 ENOG4105P66 Membrane HVX45_16915 ENOG4107QV7 Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system) (By similarity) HVX45_16920 ENOG4105DU1 integral membrane protein, terc HVX45_16925 ENOG4105EE0 oxidoreductase HVX45_16930 ENOG4108UB4 uncharacterized protein ygjQ HVX45_16935 ENOG4108VKG metal-dependent hydrolase HVX45_16940 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) HVX45_16955 ENOG4105RI1 glycoprotein receptor HVX45_16960 ENOG4106CVF DNA replication protein HVX45_16965 ENOG4108PM0 it is also involved in inducing stable DNA replication during SOS response. It forms, in concert with DnaB protein and other prepriming proteins DnaC, N, N', N'' a prepriming protein complex on the specific site of the template DNA recognized by protein N' (By similarity) HVX45_16970 ENOG4107XM3 UPF0442 protein HVX45_16975 ENOG4105DWK Membrane HVX45_16980 ENOG41072AC 4-hydroxybenzoate 3-monooxygenase HVX45_16985 ENOG4105EZV Transcriptional regulator HVX45_16990 ENOG4108N8T regulatoR HVX45_16995 ENOG4108T94 DNA-binding transcriptional activator BglJ HVX45_17000 ENOG4108819 ferric iron reductase HVX45_17005 ENOG4105YBH Protein of unknown function (DUF1435) HVX45_17025 ENOG4105D8J Specifically methylates the guanine in position 1207 of 16S rRNA in the 30S particle (By similarity) HVX45_17030 ENOG4108WPU DNA polymerase III subunit psi HVX45_17035 ENOG4105KEG ribosomal-protein-alanine acetyltransferase HVX45_17040 ENOG4105PAD Hydrolase HVX45_17050 ENOG4105K3G Periplasmic Protein HVX45_17060 ENOG4108NRW Phospholipase, patatin family HVX45_17065 ENOG4105EYA deoxyribonuclease HVX45_17070 ENOG41076CZ activating enzyme HVX45_17075 ENOG4105G0K glycine radical enzyme YjjI family HVX45_17110 ENOG41062Z9 Membrane HVX45_17115 ENOG4105EAC phosphoserine phosphatase HVX45_17120 ENOG4105DNJ May play a role in the repair of endogenous alkylation damage (By similarity) HVX45_17125 ENOG4107VZS Nicotinamide-nucleotide adenylyltransferase HVX45_17130 ENOG4105W2W Cytotoxic translational repressor of toxin-antitoxin stability system HVX45_17140 ENOG4105C5H ABC transporter HVX45_17145 ENOG4107SC1 transglycosylase HVX45_17155 ENOG4108K16 Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity) HVX45_17165 ENOG4105UEI Transcriptional Regulator AraC Family HVX45_17170 ENOG4108RH0 Crea protein HVX45_17175 ENOG4105E3W Two component transcriptional regulator (Winged helix family HVX45_17180 ENOG4105EB3 Histidine kinase HVX45_17185 ENOG4105CT7 inner membrane cred family protein HVX45_17190 ENOG41065U4 response regulator HVX45_17195 ENOG410759A HVX45_17200 ENOG4106FVC RNA methyltransferase HVX45_17210 ENOG4105CFH Aspartokinase HVX45_17220 ENOG4105D98 threonine synthase HVX45_17225 ENOG41062C6 Protein of unknown function (DUF2502) HVX45_17235 ENOG4105BZG amino acid carrier protein HVX45_17245 ENOG4108RIR Molybdenum cofactor biosynthesis protein HVX45_17250 ENOG4106HK8 GPR1 FUN34 yaaH family protein HVX45_17265 ENOG4105WI6 cell killing protein encoded within cryptic prophage HVX45_17275 ENOG41063Z6 transcriptional regulator, lysR family HVX45_17285 ENOG410647N response to DNA damage stimulus HVX45_17290 ENOG4105DTN riboflavin biosynthesis protein ribF HVX45_17295 ENOG4105C07 amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity) HVX45_17305 ENOG41090X3 Peptidyl-prolyl cis-trans isomerase HVX45_17325 ENOG4106YYS transcriptional regulatory protein HVX45_17335 ENOG4105D9Q decarboxylase (Beta subunit) HVX45_17340 ENOG4107QSA Oxaloacetate decarboxylase HVX45_17350 ENOG4105D2K citrate carrier protein HVX45_17355 ENOG4105DUA (citrate (pro-3S)-lyase ligase HVX45_17365 ENOG4105CI0 Citrate lyase HVX45_17370 ENOG4105CHY citrate lyase, alpha HVX45_17395 ENOG4105C1M carbamoyl-phosphate synthetase glutamine chain HVX45_17400 ENOG4105CU6 carbamoyl-phosphate synthetase ammonia chain HVX45_17405 ENOG4108XNW Transcriptional activatory protein CaiF HVX45_17415 ENOG4106YT9 Enoyl-CoA hydratase HVX45_17450 ENOG4105DWH electron transfer flavoprotein-ubiquinone oxidoreductase HVX45_17455 ENOG4105IBM Could be part of an electron transfer system required for anaerobic carnitine reduction. Could be a 3Fe-4S cluster- containing protein HVX45_17460 ENOG4105C54 Major Facilitator superfamily HVX45_17475 ENOG4108YYV Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity) HVX45_17510 ENOG4105DBD Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation (By similarity) HVX45_17520 ENOG41066UG Regulatory DnaK co-chaperone. Direct interaction between DnaK and DjlA is needed for the induction of the wcaABCDE operon, involved in the synthesis of a colanic acid polysaccharide capsule, possibly through activation of the RcsB RcsC phosphotransfer signaling pathway. The colanic acid capsule may help the bacterium survive conditions outside the host (By similarity) HVX45_17525 ENOG4105D3G Pseudouridine synthase HVX45_17535 ENOG4105CQ2 DNA polymerase HVX45_17555 ENOG4107R0P L-ribulose-5-phosphate 4-epimerase HVX45_17575 ENOG4108RVA ribokinase HVX45_17600 ENOG4108KF1 Membrane HVX45_17610 ENOG4106SMU thiamine transporter membrane protein HVX45_17615 ENOG4105DP9 ABC transporter HVX45_17620 ENOG4105KNR Activates the small RNA gene sgrS under glucose- phosphate stress conditions as well as yfdZ. Represses its own transcription under both stress and non-stress conditions. Might act as a sensor of the intracellular accumulation of phosphoglucose by binding these molecules in its C-terminal solute-binding domain (By similarity) HVX45_17630 ENOG4105S8Q sugar efflux transporter HVX45_17635 ENOG4105DJB Major Facilitator Superfamily HVX45_17640 ENOG4105DND Transcriptional regulator HVX45_17645 ENOG4105FF2 Type I DHQase HVX45_17650 ENOG4105EMV Major Facilitator HVX45_17665 ENOG4105MQS Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate (By similarity) HVX45_17675 ENOG4105C0C Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate (By similarity) HVX45_17690 ENOG41064T2 transcriptional regulator, lysR family HVX45_17695 ENOG4105C7K acetolactate synthase HVX45_17700 ENOG4108ZP8 Acetolactate synthase small subunit HVX45_17710 ENOG4107B7Y DNA-binding transcriptional regulator FruR HVX45_17725 ENOG41063Y6 Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic (By similarity) HVX45_17730 ENOG4105CJN penicillin-binding protein HVX45_17735 ENOG4107EEN Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan (By similarity) HVX45_17740 ENOG4108EQQ Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein (By similarity) HVX45_17750 ENOG4105DMZ Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA) (By similarity) HVX45_17755 ENOG4105CNI cell division protein FtsW HVX45_17770 ENOG4105CPF Cell wall formation (By similarity) HVX45_17775 ENOG4105K7E Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly (By similarity) HVX45_17780 ENOG4105CIT This protein may be involved in anomalous filament growth. May be a component of the septum (By similarity) HVX45_17785 ENOG4105CDK Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity) HVX45_17805 ENOG4105M6F mutator MutT protein HVX45_17820 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) HVX45_17830 ENOG4105D7Q type ii secretion system HVX45_17835 ENOG4107QHF type ii secretion system protein e HVX45_17840 ENOG4108ZUW Major pilin subunit HVX45_17845 ENOG4105D18 nicotinate-nucleotide pyrophosphorylase HVX45_17850 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase HVX45_17855 ENOG4106A72 regulatory protein AmpE HVX45_17860 ENOG4105C85 amino acid HVX45_17865 ENOG41073TP transcriptional regulator HVX45_17870 ENOG4105DAQ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2) (By similarity) HVX45_17875 ENOG4107QSN dihydrolipoamide acetyltransferase HVX45_17880 ENOG4107QN2 dihydrolipoyl dehydrogenase HVX45_17885 ENOG4108NST exported protein HVX45_17890 ENOG4107QIJ Aconitate hydratase 2 HVX45_17910 ENOG4108ZRK uncharacterized protein yacC HVX45_17915 ENOG4105E3B Multicopper oxidase HVX45_17920 ENOG4105DZG Dehydrogenase HVX45_17925 ENOG4108UGV hypoxanthine phosphoribosyltransferase HVX45_17930 ENOG41077A9 carbonic anhydrase HVX45_17935 ENOG4105DA5 (ABC) transporter HVX45_17940 ENOG4105E3A (ABC) transporter HVX45_17945 ENOG4108YTN IIa component HVX45_17950 ENOG4107BJW polysaccharide deacetylase HVX45_17960 ENOG4108A32 Transposase HVX45_17975 ENOG4105P0Q fimbrial-like protein YadC HVX45_17980 ENOG4105SN2 fimbrial-like adhesin protein HVX45_17985 ENOG4105SYG Fimbrial protein HVX45_17990 ENOG4108XEY fimbrial-like adhesin protein HVX45_17995 ENOG4105CW0 outer membrane usher protein HVX45_18000 ENOG4108VEV chaperone HVX45_18010 ENOG4105K8U 2-Amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase HVX45_18015 ENOG4105DJ0 Poly(A) Polymerase HVX45_18035 ENOG4107XID 2'-5' rna ligase HVX45_18040 ENOG4105CQ7 ATP-dependent helicase HVX45_18045 ENOG4105BZ4 penicillin-binding protein HVX45_18050 ENOG4105E0K tonB-dependent siderophore receptor HVX45_18055 ENOG4105E0A ABC, transporter HVX45_18060 ENOG4105J76 Periplasmic binding protein HVX45_18065 ENOG4105S6R Iron-hydroxamate transporter permease subunit HVX45_18090 ENOG4105EN6 Membrane HVX45_18095 ENOG4105JKQ Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Binds vitamin B12 and delivers it to the periplasmic surface of BtuC (By similarity) HVX45_18110 ENOG4105C0H protease HVX45_18115 ENOG4108IXP Carbohydrate diacid transcriptional activator CdaR HVX45_18125 ENOG4105DIN metallophosphoesterase HVX45_18140 ENOG4105CA1 Removes the N-terminal methionine from nascent proteins (By similarity) HVX45_18165 ENOG4105CEA Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity) HVX45_18170 ENOG4105CR3 Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids (By similarity) HVX45_18175 ENOG4105KNE Phosphatidate cytidylyltransferase HVX45_18180 ENOG4105DZP Membrane-associated zinc metalloprotease HVX45_18190 ENOG4108RFI Molecular chaperone that interacts specifically with outer membrane proteins, thus maintaining the solubility of early folding intermediates during passage through the periplasm (By similarity) HVX45_18195 ENOG4105D7M Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell (By similarity) HVX45_18215 ENOG4108UH2 Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) HVX45_18220 ENOG4105C0B DNA polymerase III (alpha subunit) HVX45_18225 ENOG4107QM9 Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity) HVX45_18230 ENOG4105CXN decarboxylase HVX45_18235 ENOG4108YZK glyoxalase bleomycin resistance protein dioxygenase HVX45_18240 ENOG4105D3U Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity) HVX45_18245 ENOG4105M1T rho-binding antiterminator HVX45_18255 ENOG4108VWS Yaeq family HVX45_18260 ENOG4108YZN class I peptide chain release factor HVX45_18265 ENOG4107EII Lipoprotein involved with copper homeostasis and adhesion HVX45_18270 ENOG4108UY0 (LipO)protein HVX45_18280 ENOG4108R96 Methyltransferase, YaeB family HVX45_18285 ENOG4108R8X outer membrane lipoprotein HVX45_18290 ENOG4105D01 (LipO)protein HVX45_18295 ENOG4108UMI ABC transporter, permease HVX45_18300 ENOG4108JEI Part of the ABC transporter complex MetNIQ involved in methionine import. Responsible for energy coupling to the transport system (By similarity) HVX45_18305 ENOG4108ZI0 d,d-heptose 1,7-bisphosphate phosphatase HVX45_18340 ENOG4105CV8 reductase HVX45_18345 ENOG4105HEI LysR family (Transcriptional regulator HVX45_18355 ENOG4105F2W methyltransferase HVX45_18360 ENOG4105E9H Lytic Murein transglycosylase HVX45_18370 ENOG4105D1A Methyltransferase HVX45_18380 ENOG4107RZZ dna polymerase iii epsilon subunit HVX45_18390 ENOG4105CZ7 nitrilase cyanide hydratase and apolipoprotein n-acyltransferase HVX45_18395 ENOG4108WN0 inhibitor of vertebrate lysozyme HVX45_18400 ENOG4107QPN acyl-Coa dehydrogenase HVX45_18410 ENOG4105E7A Glutamine amidotransferase HVX45_18415 ENOG4105F7V ErfK ybiS ycfS ynhG family protein HVX45_18420 ENOG4108YS0 lipoprotein YafL HVX45_18430 ENOG4105C5C n-acetylmuramoyl-l-alanine amidase HVX45_18450 ENOG4105CA3 membrane-bound lytic murein transglycosylase HVX45_18455 ENOG4105CUZ uba thif-type nad fad binding protein HVX45_18460 ENOG4105P9C Participates in cysteine desulfuration mediated by SufS. Cysteine desulfuration mobilizes sulfur from L-cysteine to yield L-alanine and constitutes an essential step in sulfur metabolism for biosynthesis of a variety of sulfur-containing biomolecules. Functions as a sulfur acceptor for SufS, by mediating the direct transfer of the sulfur atom from the S-sulfanylcysteine of SufS, an intermediate product of cysteine desulfuration process (By similarity) HVX45_18465 ENOG4105C9B Cysteine desulfurase HVX45_18470 ENOG4105M5B (LipO)protein HVX45_18475 ENOG4105ETT transcriptional Regulator, LysR family HVX45_18480 ENOG4105M08 Membrane HVX45_18495 ENOG4105EJQ L-serine dehydratase HVX45_18500 ENOG4105C44 Serine transporter HVX45_18505 ENOG4105EWT decarboxylase family HVX45_18520 ENOG4105WP7 tRNA pseudouridine synthase C HVX45_18525 ENOG4105DR9 pseudouridine synthase HVX45_18530 ENOG4105QDK Flavodoxin HVX45_18535 ENOG4105JN3 extra-cytoplasmic solute receptor family protein HVX45_18550 ENOG4105EQX glucarate dehydratase HVX45_18555 ENOG4105EQX glucarate dehydratase HVX45_18560 ENOG4105BZW Glycerate kinase HVX45_18565 ENOG4105BZU Histidine kinase HVX45_18570 ENOG4105BZT Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity) HVX45_18575 ENOG4105CWR In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity) HVX45_18580 ENOG4105DXN mazG family HVX45_18595 ENOG4105HA9 of methanol dehydrogenase type HVX45_18605 ENOG4105HA9 of methanol dehydrogenase type HVX45_18615 ENOG4105EIZ Catalyzes the conversion of 6-carboxy-5,6,7,8- tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG) (By similarity) HVX45_18625 ENOG4107ZIF 6-carboxy-5,6,7,8-tetrahydropterin synthase HVX45_18645 ENOG4107635 Hok Gef family protein HVX45_18650 ENOG4105DTT CRISPR-associated helicase, cas3 HVX45_18655 ENOG4105CYR Crispr-associated protein, cse1 family HVX45_18665 ENOG41060M0 Crispr-associated protein, cse4 family HVX45_18670 ENOG4108VWQ crispr-associated protein HVX45_18680 ENOG4105TZK CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. May be involved in the integration of spacer DNA into the CRISPR cassette (By similarity) HVX45_18685 ENOG4105PWE CRISPR-associated protein cas2 HVX45_18690 ENOG4108MXK alkaline phosphatase isozyme conversion HVX45_18710 ENOG4105N0Z inner membrane protein ygbE HVX45_18745 ENOG4108K5P (LipO)protein HVX45_18750 ENOG4105DG1 Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity) HVX45_18760 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase HVX45_18765 ENOG4105D3H Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol (By similarity) HVX45_18770 ENOG4105KZM cytoplasmic protein HVX45_18775 ENOG4105MEW serine threonine protein phosphatase HVX45_18795 ENOG4105C6V Glycerol-3-phosphate dehydrogenase HVX45_18810 ENOG4105C2J ABC transporter HVX45_18815 ENOG4105CNN ABC, transporter HVX45_18820 ENOG4105E9V Periplasmic binding protein LacI transcriptional regulator HVX45_18825 ENOG4107EDW L-fucose operon activator HVX45_18830 ENOG4105VXR cytoplasmic protein HVX45_18835 ENOG4105F4R Transcriptional regulator mode HVX45_18840 ENOG4108JUA Transcriptional regulator HVX45_18845 ENOG4105C45 hydrogenase expression formation protein (HypE) HVX45_18850 ENOG4105CQS hydrogenase expression formation protein HypD HVX45_18855 ENOG41083WG hydrogenase assembly chaperone HVX45_18860 ENOG4107RSS Hydrogenase accessory protein HypB HVX45_18865 ENOG410816D Probably plays a role in a hydrogenase nickel cofactor insertion step (By similarity) HVX45_18870 ENOG4108VRC Formate hydrogenlyase regulatory protein hycA HVX45_18875 ENOG4108MFN small subunit of hydrogenase-3, iron-sulfur protein (part of formate hydrogenlyase (FHL) complex) HVX45_18880 ENOG4107R30 NADH dehydrogenase HVX45_18885 ENOG4107TDF Formate hydrogenlyase subunit 4 HVX45_18890 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HVX45_18895 ENOG4108RG7 formate hydrogenlyase complex iron-sulfur subunit HVX45_18900 ENOG4105C47 NADH ubiquinone oxidoreductase 20 kda subunit HVX45_18905 ENOG4105I6X formate hydrogenlyase maturation HVX45_18910 ENOG4108MG9 hydrogenase 3 maturation protease HVX45_18920 ENOG4105RVE Uncharacterized protein conserved in bacteria (DUF2136) HVX45_18925 ENOG4108Z3N Transcriptional regulator HVX45_18930 ENOG4105CS2 ec 3.2.1.21 HVX45_18935 ENOG4105C5Y PTS System HVX45_18940 ENOG4105DDV Transcriptional regulator (LacI family HVX45_18945 ENOG4108RC0 Electron transport protein HVX45_18950 ENOG4105C8H hydrogenase maturation protein Hypf HVX45_18970 ENOG4105C2X Arabinose 5-phosphate isomerase HVX45_18980 ENOG4105CVE Lytic murein transglycosylase HVX45_18990 ENOG4107TH8 cina domain protein HVX45_19010 ENOG4105VM8 Could accelerate the degradation of some genes transcripts potentially through selective RNA binding (By similarity) HVX45_19040 ENOG4107VXZ Hydrolase HVX45_19045 ENOG4105W39 Membrane HVX45_19060 ENOG4105C0R drug resistance transporter emrb qaca subfamily HVX45_19065 ENOG4105CW7 secretion protein, HlyD family HVX45_19070 ENOG4105NTK Transcriptional repressor Mpra HVX45_19075 ENOG4105ZED uncharacterized protein ygaH HVX45_19080 ENOG4108UMN azlc family HVX45_19090 ENOG4105GIJ Glycine betaine HVX45_19095 ENOG4108HQS Glycine betaine HVX45_19100 ENOG4108IJ7 Glycine betaine HVX45_19105 ENOG4107R25 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HVX45_19110 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HVX45_19120 ENOG4105WAZ (Glutaredoxin-like protein) NrdH HVX45_19125 ENOG4105MDH Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity (By similarity) HVX45_19135 ENOG4108ZQZ Bacterial protein of unknown function (DUF883) HVX45_19140 ENOG4108WMJ Protein of unknown function (DUF2002) HVX45_19150 ENOG4108X73 DNA- binding protein HVX45_19155 ENOG4108V62 Rhodanese domain protein HVX45_19160 ENOG41080HT Transcriptional regulator, arsr family HVX45_19165 ENOG4105VPI YqaE family transport protein HVX45_19170 ENOG4109066 lysm domain bon superfamily protein HVX45_19175 ENOG4108PVQ transcriptional regulator HVX45_19180 ENOG4105C85 amino acid HVX45_19185 ENOG4108JPW Aminotransferase HVX45_19190 ENOG4105C26 Dehydrogenase HVX45_19195 ENOG4105D5U fad dependent oxidoreductase HVX45_19205 ENOG4108NUU Transcriptional regulator HVX45_19210 ENOG4105SZ2 membrAne HVX45_19215 ENOG4107SNB ankyrin repeat protein YahD HVX45_19220 ENOG4105N16 Protein of unknown function (DUF2877) HVX45_19225 ENOG4107R1Q Membrane protein FdrA HVX45_19230 ENOG4107REC cytoplasmic protein HVX45_19235 ENOG4105C5B carbamate kinase HVX45_19240 ENOG4105DZC cytosine deaminase HVX45_19245 ENOG4105DTA methyltransferase HVX45_19255 ENOG4105DQ4 alcohol dehydrogenase HVX45_19260 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) HVX45_19265 ENOG4108YZG isomerase HVX45_19275 ENOG4105CMT Dihydroxyacetone kinase HVX45_19280 ENOG4105CP7 Triose-phosphate isomerase HVX45_19285 ENOG4108KFM Xylose Isomerase Domain-Containing protein HVX45_19290 ENOG4106J7G oxidoreductase HVX45_19295 ENOG4105DKT Transcriptional regulator HVX45_19300 ENOG41083A2 UPF0145 protein HVX45_19305 ENOG4105Y50 Virulence Protein HVX45_19315 ENOG4107R08 Integrase HVX45_19330 ENOG41077V0 CPS-53 (KpLE1) prophage HVX45_19335 ENOG4108R7K Metal Dependent Phosphohydrolase HVX45_19360 ENOG4108S1U HVX45_19390 ENOG4106CZA Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC (By similarity) HVX45_19400 ENOG4108MXB Protein of unknown function (DUF968) HVX45_19405 ENOG4105HGD Antitermination protein HVX45_19420 ENOG4105VEQ Cold shock protein HVX45_19425 ENOG4105QFS Lysis protein S homolog from lambdoid prophage HVX45_19445 ENOG4108YV9 Protein of unknown function (DUF2514) HVX45_19450 ENOG4105VEQ Cold shock protein HVX45_19460 ENOG4106IAW HVX45_19465 ENOG4106H71 Overexpression increases levels of unsaturated fatty acids and suppresses both the temperature-sensitive fabA6 mutation and cold-sensitive secG null mutation HVX45_19575 ENOG410685N tail fiber protein HVX45_19580 ENOG4105UZW Tail fiber assembly protein HVX45_19605 ENOG4108Z1B Cyclase dehydrase HVX45_19615 ENOG4105YRI Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) HVX45_19620 ENOG4105C4F May be involved in recombinational repair of damaged DNA (By similarity) HVX45_19635 ENOG4108JU6 CBS domain protein HVX45_19640 ENOG4106KVJ cytochrome C assembly protein HVX45_19645 ENOG4105CB9 Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY HVX45_19670 ENOG4105QP9 Protein of unknown function (DUF2799) HVX45_19675 ENOG4105E99 Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP) (By similarity) HVX45_19680 ENOG4105EHE chorismate mutase- prephenate dehydrogenase HVX45_19685 ENOG4105CQC Prephenate dehydratase HVX45_19695 ENOG4108WPH sigma 54 modulation protein ribosomal protein S30EA HVX45_19700 ENOG4106SNF Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane HVX45_19705 ENOG4105C34 Pseudouridine synthase HVX45_19710 ENOG4105DBW Multi-copper polyphenol oxidoreductase laccase HVX45_19715 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit HVX45_19740 ENOG4105CSH Transporter HVX45_19745 ENOG4105T42 (LipO)protein HVX45_19750 ENOG4105JIM Phosphatidylserine synthase HVX45_19755 ENOG4105CD5 CoA-binding domain protein HVX45_19760 ENOG4106IUH DTW domain containing protein HVX45_19765 ENOG4105K63 Thioredoxin HVX45_19770 ENOG4105EIB trna rrna methyltransferase HVX45_19795 ENOG4105C1J atp-dependent rna helicase HVX45_19805 ENOG4108IYU L-aspartate oxidase HVX45_19815 ENOG4105EMN RNA polymerase sigma factor HVX45_19820 ENOG41069PW sigma-e factor negative regulatory protein HVX45_19825 ENOG4105VQK sigma E regulatory protein, MucB RseB HVX45_19830 ENOG4105WMJ Positive regulator of sigma E, RseC MucC HVX45_19840 ENOG4105C3F Signal peptidase i HVX45_19860 ENOG4105CSZ Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate (By similarity) HVX45_19875 ENOG4105K5D 4fe-4S ferredoxin iroN-sulfur binding HVX45_19880 ENOG4106G6Q Transcriptional regulator HVX45_19885 ENOG4105HYY HAD superfamily (Subfamily IF) hydrolase, YfhB HVX45_19890 ENOG4108Z6B deaminase HVX45_19900 ENOG4108ETH Formylglycinamide ribotide synthetase HVX45_19905 ENOG4107WP9 Histidine kinase HVX45_19910 ENOG4108SKK alpha helix protein HVX45_19915 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family HVX45_19940 ENOG4107RE1 Inosine-guanosine kinase HVX45_19955 ENOG4105CKD glutathione-regulated potassium-efflux system protein HVX45_19960 ENOG4105EU0 Major facilitator Superfamily HVX45_19965 ENOG4105CGH 5'-nucleotidase HVX45_19980 ENOG4108Z66 YbaK ebsC protein HVX45_19985 ENOG4105MBR gumn family HVX45_19990 ENOG41080ET plasmid maintenance system killer protein HVX45_19995 ENOG41081XE plasmid maintenance system antidote protein, xre family HVX45_20000 ENOG4105C59 p-type ATPase HVX45_20005 ENOG4107RY6 amino acid HVX45_20025 ENOG4107QZV Type I secretion membrane fusion protein HVX45_20030 ENOG4108Z6Z Transcriptional regulator HVX45_20035 ENOG4105G5H Membrane HVX45_20040 ENOG4107QX8 SPFH domain, Band 7 family protein HVX45_20045 ENOG41083J0 (ABC) transporter HVX45_20050 ENOG4105C4B ABC transporter, permease HVX45_20055 ENOG4107QR8 Thioredoxin HVX45_20060 ENOG4105E1F short-chain dehydrogenase reductase HVX45_20065 ENOG4108UJV acyl-CoA thioesterase i HVX45_20070 ENOG4108I0Y (ABC) transporter HVX45_20075 ENOG4105CV6 ABC transporter, permease HVX45_20080 ENOG4105GMB type VI secretion system effector, hcp1 family HVX45_20095 ENOG4105G5A Protein of unknown function (DUF2877) HVX45_20100 ENOG4105C5B carbamate kinase HVX45_20105 ENOG4105CY8 phosphoribosylaminoimidazole carboxylase atpase subunit HVX45_20110 ENOG4108UM6 Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR) (By similarity) HVX45_20125 ENOG4108R5K PPIases accelerate the folding of proteins (By similarity) HVX45_20135 ENOG4105S2T inner membrane protein YbcI HVX45_20140 ENOG4105WQ3 Rna-binding protein HVX45_20175 ENOG4105CKK Glycosyl transferase, family 2 HVX45_20180 ENOG4105IHM Involved in O antigen modification. Involved in the translocation of bactoprenol-linked glucose across the cytoplasmic membrane (By similarity) HVX45_20185 ENOG4108EGH Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) HVX45_20195 ENOG4108SB3 DoxX Family HVX45_20200 ENOG4105D8G Major Facilitator superfamily HVX45_20205 ENOG4108MN2 Stationary phase inducible protein CsiE HVX45_20210 ENOG4107XM9 (LipO)protein HVX45_20215 ENOG4105ECY inositol monophosphatase HVX45_20235 ENOG4107XTC May be involved in the formation or repair of Fe-S clusters present in iron-sulfur proteins HVX45_20255 ENOG4108ZIT Ferredoxin, 2FE-2S HVX45_20260 ENOG4105WVQ Fe-S assembly protein IscX HVX45_20270 ENOG4105YYA enhanced serine sensitivity protein SseB HVX45_20275 ENOG4105KHC sulfurtransferase HVX45_20280 ENOG4105DN3 alpha-2-macroglobulin domain protein HVX45_20285 ENOG4108JQB penicillin-binding protein 1C HVX45_20315 ENOG4105N21 Membrane HVX45_20330 ENOG4105VPD cellular component movement HVX45_20355 ENOG4105CP4 Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity) HVX45_20370 ENOG41066DY Membrane HVX45_20375 ENOG4108ZMA Outer membrane lipoprotein HVX45_20380 ENOG41062G3 Protein of unknown function (DUF2633) HVX45_20385 ENOG4105BZU Histidine kinase HVX45_20390 ENOG4105C9X ppx gppa phosphatase HVX45_20395 ENOG4105CUU Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity) HVX45_20400 ENOG4108V3E phosphoribosylglycinamide formyltransferase HVX45_20415 ENOG4105C2W permease HVX45_20420 ENOG4108KZ1 Mediates the interaction of DNA replication inititator protein DnaA with DNA polymerase subunit beta sliding clamp (dnaN). Stimulates hydrolysis of ATP-DnaA to ADP-DnaA, rendering DnaA inactive for reinititation, a process called regulatory inhibition of DnaA or RIDA (By similarity) HVX45_20425 ENOG4105K89 arsenate reductase HVX45_20430 ENOG4105ERG peptidase m48, ste24p HVX45_20435 ENOG4105C02 permease HVX45_20440 ENOG4108JUA Transcriptional regulator HVX45_20445 ENOG4105I6X formate hydrogenlyase maturation HVX45_20450 ENOG4105C47 NADH ubiquinone oxidoreductase 20 kda subunit HVX45_20460 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HVX45_20465 ENOG4108JPZ Monovalent cation H antiporter subunit D HVX45_20470 ENOG4107WQX hydrogenase 4 membrane subunit HVX45_20475 ENOG4105D65 subunit l HVX45_20480 ENOG4107TDF Formate hydrogenlyase subunit 4 HVX45_20485 ENOG4108JPZ Monovalent cation H antiporter subunit D HVX45_20490 ENOG4108MFN small subunit of hydrogenase-3, iron-sulfur protein (part of formate hydrogenlyase (FHL) complex) HVX45_20495 ENOG4108YXY alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen HVX45_20500 ENOG4105RH4 Glycine cleavage system transcriptional repressor HVX45_20510 ENOG4107EG0 Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane (By similarity) HVX45_20520 ENOG4105CGZ zinc metallopeptidase HVX45_20530 ENOG4106KED esterase YpfH HVX45_20545 ENOG4105KUZ arsenate reductase HVX45_20555 ENOG4105BZS acriflavin resistance protein HVX45_20560 ENOG4105BZU Histidine kinase HVX45_20565 ENOG4105BZ8 glutamate synthase HVX45_20575 ENOG4108PVD exported protein HVX45_20580 ENOG4105CV1 Transketolase (EC 2.2.1.1) HVX45_20585 ENOG4105CW3 Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) HVX45_20590 ENOG4105C6K Malic enzyme HVX45_20600 ENOG4107H8F HVX45_20610 ENOG4108KNB n-acetylmuramoyl-l-alanine amidase HVX45_20620 ENOG4105QZU Inner membrane protein YfeZ HVX45_20625 ENOG4105E7K (LipO)protein HVX45_20630 ENOG4105EZR dyp-type peroxidase family protein HVX45_20635 ENOG4107S1E Beta-lactamase HVX45_20640 ENOG4105C5Y PTS System HVX45_20655 ENOG4105I7Z Short-chain dehydrogenase reductase Sdr HVX45_20660 ENOG4108J2H Sulfate ABC transporter periplasmic sulfate-binding protein HVX45_20665 ENOG4108I5D sulfate abc transporter HVX45_20670 ENOG4105ECW sulfate abc transporter HVX45_20675 ENOG4108IJ6 ABC transporter HVX45_20680 ENOG4105C6T cysteine synthase HVX45_20685 ENOG4105WEC Molybdate metabolism regulator HVX45_20690 ENOG4105M0Y HVX45_20700 ENOG4105C5Y PTS System HVX45_20705 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) HVX45_20715 ENOG4105C6T cysteine synthase HVX45_20725 ENOG4107NPY receptor for the septal ring structure, may anchor it to the inner-membrane (By similarity) HVX45_20735 ENOG4105VRT cytoplasmic protein HVX45_20740 ENOG4105DHU Bile acid HVX45_20745 ENOG4108NFH Sugar hydrolase HVX45_20750 ENOG4107U5R The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (By similarity) HVX45_20755 ENOG4105EAA nucleoside HVX45_20765 ENOG4105CN8 Transcriptional regulator HVX45_20795 ENOG4105GXM Putative transcription regulator (DUF1323) HVX45_20800 ENOG4105HZG regulatoR HVX45_20815 ENOG4108KMM Diguanylate cyclase HVX45_20820 ENOG4105D9N nucleoside HVX45_20830 ENOG4109076 Conserved Protein HVX45_20845 ENOG4105R6B The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane (By similarity) HVX45_20850 ENOG410863U PTS System HVX45_20855 ENOG4105DC7 peptidase M24 HVX45_20860 ENOG4105CN9 Peptidase m42 family protein HVX45_20865 ENOG4105BZ3 General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity) HVX45_20870 ENOG4108CIP transcriptional regulator HVX45_20875 ENOG4105DY9 regulatoR HVX45_20880 ENOG4108HRK Histidine kinase HVX45_20885 ENOG4105CHM Aminotransferase HVX45_20895 ENOG4105D1S lipid A biosynthesis HVX45_20900 ENOG4105W9M Membrane HVX45_20915 ENOG4105C3P Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity) HVX45_20935 ENOG4108Q89 anthranilate 1,2-dioxygenase large subunit HVX45_20945 ENOG4105CHR reductase HVX45_20955 ENOG4107YAQ Catalyzes the reduction of FMN to FMNH2 which is used to reduce pyrimidine by RutA via the Rut pathway (By similarity) HVX45_20970 ENOG4105S64 Formate nitrite transporter HVX45_20975 ENOG410903C (LipO)protein HVX45_20980 ENOG4105CKF membrane protein involved in aromatic hydrocarbon degradation HVX45_20985 ENOG4105KZW UPF0381 protein HVX45_21000 ENOG4108BY2 phosphohistidine phosphatase HVX45_21010 ENOG4106PG1 outer membrane usher protein HVX45_21015 ENOG4108FZ9 Chaperone HVX45_21020 ENOG4105NEV Fimbrial HVX45_21025 ENOG4105UGQ Fimbrial HVX45_21030 ENOG4105US4 fimbrial-like protein yfcP HVX45_21060 ENOG4105EJ9 Membrane HVX45_21065 ENOG4108BPE -transporting atpase HVX45_21070 ENOG4105MH2 YfcL protein HVX45_21075 ENOG4105CWG Catalyzes the last two steps in the biosynthesis of 5- methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at the wobble position (U34) in tRNA. Catalyzes the FAD-dependent demodification of cmnm(5)s(2)U34 to nm(5)s(2)U34, followed by the transfer of a methyl group from S-adenosyl-L-methionine to nm(5)s(2)U34, to form mnm(5)s(2)U34 (By similarity) HVX45_21080 ENOG4105C0Q Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity) HVX45_21085 ENOG4105F9N Major Facilitator Superfamily HVX45_21090 ENOG4106WZ1 flagella biosynthesis regulator HVX45_21100 ENOG4105CM3 Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity) HVX45_21110 ENOG4105DQR SNARE associated Golgi HVX45_21120 ENOG4105DPM folylpolyglutamate synthase Dihydrofolate synthase HVX45_21125 ENOG4108S3P Sporulation domain protein HVX45_21130 ENOG4105E96 Colicin v production protein HVX45_21135 ENOG4105CBA glutamine phosphoribosylpyrophosphate amidotransferase HVX45_21140 ENOG4108UMA 3-octaprenyl-4-hydroxybenzoate carboxy-lyase HVX45_21145 ENOG4105E89 ABC transporter HVX45_21150 ENOG4105E89 ABC transporter HVX45_21155 ENOG4105DSP amino acid AbC transporter HVX45_21160 ENOG4106YG3 ABC transporter HVX45_21165 ENOG4108JEH abc transporter atp-binding protein HVX45_21170 ENOG4105DNE Transposase HVX45_21175 ENOG4105ECP epimerase HVX45_21180 ENOG4105KKP D-erythro-7,8-dihydroneopterin triphosphate 2'-epimerase HVX45_21185 ENOG4105CYM Glutathione S-transferase HVX45_21190 ENOG4108SHQ Glutathione S-transferase HVX45_21195 ENOG4108RE9 Phosphodiesterase HVX45_21200 ENOG4105PTV Nudix Hydrolase HVX45_21205 ENOG4105K2J Transcriptional regulator HVX45_21225 ENOG4108HHA Transketolase HVX45_21230 ENOG4105C2V Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity) HVX45_21235 ENOG4105C6K Malic enzyme HVX45_21240 ENOG4105C6H Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity) HVX45_21250 ENOG4105XWI UPF0304 protein HVX45_21255 ENOG4105EVE HAD-superfamily hydrolase subfamily IA variant 3 HVX45_21260 ENOG4107QWE )-transporter HVX45_21265 ENOG4105DK2 UPF0207 protein HVX45_21270 ENOG4105CHM Aminotransferase HVX45_21275 ENOG4107NQ8 LysR family Transcriptional regulator HVX45_21290 ENOG4105CQV NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity) HVX45_21295 ENOG4105GKE subunit e HVX45_21300 ENOG4107QIZ NADH dehydrogenase HVX45_21305 ENOG4108IEH NADH dehydrogenase subunit g HVX45_21320 ENOG4107UFS subunit j HVX45_21330 ENOG4105D65 subunit l HVX45_21335 ENOG4105C8S subunit m HVX45_21345 ENOG4105ZD8 HVX45_21355 ENOG4105GDX Domain of unknown function (DUF1877) HVX45_21360 ENOG4105CP2 von willebrand factor, type a HVX45_21375 ENOG4107YB6 acetyltransferase, (GNAT) family HVX45_21380 ENOG4105TNS Conserved Protein HVX45_21385 ENOG4105E4F Isochorismate synthase HVX45_21400 ENOG4108IPT Naphthoate synthase HVX45_21410 ENOG4105CEY Amp-dependent synthetase and ligase HVX45_21415 ENOG4106GZG polymyxin resistance protein B HVX45_21465 ENOG4108UII YfaZ family HVX45_21470 ENOG4108EWA cinA-like protein HVX45_21485 ENOG4105DNE Transposase HVX45_21490 ENOG4105CHG glycolate oxidase (iron-sulfur subunit) HVX45_21500 ENOG4107R5Y anaerobic glycerol-3-phosphate dehydrogenase, subunit A HVX45_21505 ENOG4105CXY transporter HVX45_21510 ENOG4106MZZ glycerophosphoryl diester phosphodiesterase HVX45_21515 ENOG4105FQR PH-inducible protein involved in stress response HVX45_21520 ENOG4105XPH Ferredoxin HVX45_21525 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HVX45_21530 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HVX45_21535 ENOG4107GHC outer membrane autotransporter HVX45_21545 ENOG4105C24 DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity) HVX45_21550 ENOG4105CHU acetyl-coa acetyltransferase HVX45_21555 ENOG4105CRW Short chain fatty acid transporter HVX45_21560 ENOG4107QNJ CoA-transferase subunit B HVX45_21565 ENOG4107QP7 CoA-transferase subunit A HVX45_21570 ENOG4105C1W two component, sigma54 specific, transcriptional regulator, Fis family HVX45_21575 ENOG4105BZU Histidine kinase HVX45_21580 ENOG4105BZU Histidine kinase HVX45_21585 ENOG41068CG regulatoR HVX45_21590 ENOG4105E3G Phosphotransfer intermediate protein in two-component regulatory system with RcsBC HVX45_21595 ENOG4105FCK Membrane HVX45_21600 ENOG4105CJ2 (LipO)protein HVX45_21605 ENOG4105K85 Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) in DNA. Repairs alkylated guanine in DNA by stoichiometrically transferring the alkyl group at the O-6 position to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated (By similarity) HVX45_21610 ENOG4105CF1 Alkylated DNA repair protein HVX45_21615 ENOG4105IBP Cyclic peptide transporter HVX45_21625 ENOG4105CDA abc transporter atp-binding protein HVX45_21630 ENOG4105E5Q amino acid AbC transporter HVX45_21635 ENOG4107R0W ABC transporter HVX45_21645 ENOG4107AQZ Membrane HVX45_21650 ENOG4108T1M outer membrane protein x HVX45_21655 ENOG4108I6E Sulfatase HVX45_21665 ENOG4105KST dependent repressor HVX45_21670 ENOG4105F4P )-transporter HVX45_21675 ENOG4107N1Q ErfK YbiS YcfS YnhG family protein HVX45_21680 ENOG4105C5H ABC transporter HVX45_21685 ENOG4108HCJ Hydrolase HVX45_21695 ENOG4105F1A Pyruvate formate-lyase HVX45_21700 ENOG4107T9Z Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity) HVX45_21705 ENOG4105D06 uba thif-type nad fad binding protein HVX45_21710 ENOG4105CVM Molybdenum cofactor synthesis domain protein HVX45_21715 ENOG4108JQ6 ABC transporter HVX45_21720 ENOG4105DEF Extracellular solute-binding protein, family 5 HVX45_21725 ENOG4105CJM Binding-protein-dependent transport systems, inner membrane component HVX45_21735 ENOG4105BZU Histidine kinase HVX45_21740 ENOG41064RH membrane protein YliF HVX45_21750 ENOG4105UFT Represses biofilm formation in M9C glu and LB glu media but not in M9C and LB media. Seems to act as a global regulator of several genes involved in catabolite repression and stress response and regulation of the uptake and export of signaling pathways. Could be involved the regulation of indole as well as uptake and export of AI-2 through a cAMP-dependent pathway HVX45_21755 ENOG4105D8V Glucose sorbosone dehydrogenase HVX45_21760 ENOG4108TGY Glutathione S-transferase HVX45_21765 ENOG4105DZ1 carboxypeptidase HVX45_21770 ENOG4107FB0 transcriptional regulator DeoR family HVX45_21775 ENOG4105D1E Undecaprenyl pyrophosphate phosphatase HVX45_21780 ENOG4107QF7 multi-drug HVX45_21790 ENOG4108HCJ Hydrolase HVX45_21795 ENOG4106UW1 Major Facilitator superfamily HVX45_21800 ENOG4108RFG Tetr family transcriptional regulator HVX45_21810 ENOG4105GWF inner membrane protein YbjM HVX45_21815 ENOG4108DBC nitroreductase HVX45_21825 ENOG4108RMJ sensory transduction regulator HVX45_21830 ENOG4107RUE extracellular solute-binding protein family 1 HVX45_21835 ENOG4105C53 Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity) HVX45_21840 ENOG4105F38 ABC transporter, permease HVX45_21845 ENOG4105D38 putrescine abc transporter HVX45_21850 ENOG4105RBQ inner membrane protein ybjO HVX45_21860 ENOG4106TNF Periplasmic binding protein HVX45_21865 ENOG4105DMR ABC, transporter HVX45_21870 ENOG4105GBT ABC transporter HVX45_21875 ENOG4106PMH Extracellular solute-binding protein family 3 HVX45_21880 ENOG4105E5Z arginine transporter ATP-binding subunit HVX45_21885 ENOG41064MM (LipO)protein HVX45_21895 ENOG4108VBV N-Acetylmuramoyl-L-alanine amidase HVX45_21900 ENOG4107VBM 3-beta hydroxysteroid dehydrogenase isomerase HVX45_21905 ENOG4105CGD Nad-dependent epimerase dehydratase HVX45_21910 ENOG4105C5W Aldolase HVX45_21915 ENOG4105C7K acetolactate synthase HVX45_21925 ENOG4105CJJ Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress (By similarity) HVX45_21935 ENOG4105DWU Membrane HVX45_21940 ENOG4105EQR Transposase IS116 IS110 IS902 HVX45_21945 ENOG4105D8C Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity (By similarity) HVX45_21950 ENOG4105CPB ATP-dependent endonuclease of the OLD family HVX45_21955 ENOG4108MJ5 VirK protein HVX45_21960 ENOG4105DJY efflux transporter, rnd family, mfp subunit HVX45_21970 ENOG4105VEQ Cold shock protein HVX45_21980 ENOG4105C2Z ATP-dependent CLP protease ATP-binding subunit HVX45_21990 ENOG4105K9U however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity) HVX45_22000 ENOG4108JJ8 (ABC) transporter HVX45_22005 ENOG4108JJ9 ABC, transporter HVX45_22010 ENOG4105C3M thioredoxin reductase HVX45_22020 ENOG4105CNU cell division protein FtsK HVX45_22030 ENOG4105D1H recombination factor protein RarA HVX45_22040 ENOG4105CHJ isochorismatase hydrolase HVX45_22050 ENOG4105E5D amino acid HVX45_22060 ENOG4105F1A Pyruvate formate-lyase HVX45_22065 ENOG4108IYS Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity) HVX45_22165 ENOG4105VEQ Cold shock protein HVX45_22170 ENOG4106J5W DNA polymerase III (alpha subunit) HVX45_22200 ENOG41090BQ Glutaredoxin HVX45_22340 ENOG410685N tail fiber protein HVX45_22375 ENOG4108NYK Tape measure protein HVX45_22420 ENOG4107VGF ig domain protein group 2 domain protein HVX45_22465 ENOG4105FA0 parb-like partition protein HVX45_22470 ENOG410636K Effects nucleoid occlusion by binding relatively nonspecifically to DNA and preventing the assembly of the division machinery in the vicinity of the nucleoid, especially under conditions that disturb the cell cycle. It helps to coordinate cell division and chromosome segregation by preventing the formation of the Z ring through the nucleoid, which would cause chromosome breakage (By similarity) HVX45_22475 ENOG4105CB5 ATP-dependent DNA helicase recG HVX45_22555 ENOG4105D1F ATP-binding protein HVX45_22560 ENOG4105KT5 UmuD protein HVX45_22645 ENOG4108UMW Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity) HVX45_22675 ENOG4108ZQD Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity) HVX45_22690 ENOG4105C0V Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity) HVX45_22700 ENOG4105E05 Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HVX45_22705 ENOG4105BZH Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity) HVX45_22845 ENOG41073YN Protein of unknown function (DUF1380) HVX45_22850 ENOG4106JQ7 HVX45_22885 ENOG4105FEQ ParB domain protein nuclease HVX45_23090 ENOG4105CZX twitching motility protein HVX45_23150 ENOG4105K5T PilT protein HVX45_23165 ENOG4107QHF type ii secretion system protein e HVX45_23205 ENOG4108YXQ IS66 Orf2 family protein HVX45_23210 ENOG4105E5H Transposase