locus-tag	class	description
HVX45_00025	COG4695	Portal protein
HVX45_00115	COG5301	cellulose 1,4-beta-cellobiosidase activity
HVX45_00120	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
HVX45_00175	COG1882	Formate acetyltransferase
HVX45_00180	COG2116	formate transmembrane transporter activity
HVX45_00185	COG1944	ATP diphosphatase activity
HVX45_00190	COG2323	membrane
HVX45_00210	COG0539	negative regulation of cytoplasmic translation
HVX45_00220	COG0658	competence protein
HVX45_00220	COG2333	competence protein COMEC
HVX45_00235	COG3214	Protein conserved in bacteria
HVX45_00250	COG3173	Aminoglycoside phosphotransferase
HVX45_00255	COG1434	Gram-negative-bacterium-type cell wall biogenesis
HVX45_00260	COG2227	3-demethylubiquinone-9 3-O-methyltransferase activity
HVX45_00270	COG3095	Involved in chromosome condensation, segregation and cell cycle progression. May participate in facilitating chromosome segregation by condensation DNA from both sides of a centrally located replisome during cell division. Probably acts via its interaction with MukB and MukF
HVX45_00280	COG2989	Protein conserved in bacteria
HVX45_00285	COG3108	Peptidase M15
HVX45_00290	COG0491	Thiolesterase that catalyzes the hydrolysis of S-D- lactoyl-glutathione to form glutathione and D-lactic acid
HVX45_00295	COG1448	Aminotransferase
HVX45_00315	COG0308	aminopeptidase N
HVX45_00320	COG1116	anion transmembrane transporter activity
HVX45_00325	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HVX45_00335	COG0715	COG0715 ABC-type nitrate sulfonate bicarbonate transport systems periplasmic components
HVX45_00340	COG0431	NADPH-dependent FMN reductase
HVX45_00355	COG3217	Mosc domain protein beta barrel domain protein
HVX45_00355	COG0633	Ferredoxin
HVX45_00365	COG0488	(ABC) transporter
HVX45_00370	COG2995	paraquat-inducible protein a
HVX45_00375	COG3008	intermembrane lipid transfer
HVX45_00375	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HVX45_00380	COG3009	Protein conserved in bacteria
HVX45_00385	COG3130	regulation of translation
HVX45_00395	COG1067	ATP-dependent peptidase activity
HVX45_00415	COG3070	regulator of competence-specific genes
HVX45_00420	COG1289	transmembrane transporter activity
HVX45_00425	COG3304	Inner membrane component domain
HVX45_00430	COG0210	DNA helicase
HVX45_00445	COG1832	CoA-binding protein
HVX45_00460	COG1254	Belongs to the acylphosphatase family
HVX45_00465	COG2920	part of a sulfur-relay system
HVX45_00470	COG0670	Belongs to the BI1 family
HVX45_00485	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
HVX45_00490	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
HVX45_00495	COG1969	Ni Fe-hydrogenase, b-type cytochrome subunit
HVX45_00500	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
HVX45_00505	COG1999	signal sequence binding
HVX45_00510	COG1773	rubredoxin
HVX45_00515	COG3318	Belongs to the UPF0149 family
HVX45_00515	COG3012	SEC-C Motif Domain Protein
HVX45_00520	COG0814	amino acid
HVX45_00530	COG1528	Iron-storage protein
HVX45_00540	COG1528	Iron-storage protein
HVX45_00545	COG1879	ABC-type sugar transport system periplasmic component
HVX45_00550	COG1129	ABC transporter
HVX45_00555	COG1172	Belongs to the binding-protein-dependent transport system permease family
HVX45_00560	COG1877	trehalose-phosphatase activity
HVX45_00570	COG0589	response to stress
HVX45_00585	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
HVX45_00595	COG0643	Histidine kinase
HVX45_00595	COG2198	Histidine kinase
HVX45_00600	COG0835	chemotaxis
HVX45_00630	COG0840	transmembrane signaling receptor activity
HVX45_00645	COG0745	RESPONSE REGULATOR receiver
HVX45_00675	COG0583	DNA-binding transcription factor activity
HVX45_00700	COG3729	General stress protein
HVX45_00705	COG1309	transcriptional regulator
HVX45_00710	COG2200	EAL domain
HVX45_00715	COG2199	diguanylate cyclase activity
HVX45_00725	COG1215	transferase activity, transferring glycosyl groups
HVX45_00730	COG0425	Belongs to the sulfur carrier protein TusA family
HVX45_00735	COG2391	methyltransferase activity
HVX45_00745	COG0366	Alpha amylase catalytic
HVX45_00800	COG2197	response regulator
HVX45_00810	COG2197	response regulator
HVX45_00840	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HVX45_00845	COG1271	oxidase subunit
HVX45_00850	COG1294	oxidase, subunit
HVX45_00865	COG2205	protein histidine kinase activity
HVX45_00865	COG2198	Histidine kinase
HVX45_00865	COG0784	Response regulator, receiver
HVX45_00870	COG1879	ABC-type sugar transport system periplasmic component
HVX45_00875	COG0745	RESPONSE REGULATOR receiver
HVX45_00880	COG3005	denitrification pathway
HVX45_00885	COG0243	molybdopterin cofactor binding
HVX45_00900	COG1298	Required for formation of the rod structure of the flagellar apparatus. Together with FliI and FliH, may constitute the export apparatus of flagellin
HVX45_00915	COG3102	Protein conserved in bacteria
HVX45_00935	COG3788	relative of glutathione S-transferase, MAPEG superfamily
HVX45_00940	COG1801	Protein of unknown function DUF72
HVX45_00945	COG1335	isochorismatase
HVX45_00955	COG0494	nUDIX hydrolase
HVX45_00960	COG0217	transcriptional regulatory protein
HVX45_01000	COG1108	ABC-type Mn2 Zn2 transport systems permease components
HVX45_01010	COG4531	ABC-type Zn2 transport system, periplasmic component surface adhesin
HVX45_01015	COG0739	heme binding
HVX45_01020	COG1560	Kdo2-lipid A biosynthetic process
HVX45_01025	COG0469	pyruvate kinase activity
HVX45_01030	COG1737	Transcriptional regulator
HVX45_01035	COG0364	Catalyzes the oxidation of glucose 6-phosphate to 6- phosphogluconolactone
HVX45_01040	COG0129	dihydroxy-acid dehydratase activity
HVX45_01045	COG0800	Aldolase
HVX45_01055	COG3141	response to X-ray
HVX45_01065	COG2979	Protein of unknown function (DUF533)
HVX45_01070	COG1770	oligopeptidase
HVX45_01075	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HVX45_01080	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HVX45_01090	COG2372	response to copper ion
HVX45_01095	COG1276	copper resistance
HVX45_01105	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HVX45_01125	COG3008	intermembrane lipid transfer
HVX45_01130	COG2995	paraquat-inducible protein a
HVX45_01135	COG1956	GAF domain-containing protein
HVX45_01155	COG2814	Major facilitator Superfamily
HVX45_01160	COG1414	Transcriptional regulator
HVX45_01190	COG2226	methyltransferase
HVX45_01205	COG3716	PTS system mannose fructose sorbose family IID component
HVX45_01210	COG3715	PTS system
HVX45_01215	COG3444	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HVX45_01215	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HVX45_01220	COG1253	flavin adenine dinucleotide binding
HVX45_01225	COG2200	EAL domain
HVX45_01230	COG1760	l-serine dehydratase
HVX45_01240	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HVX45_01260	COG0251	oxidation-reduction process
HVX45_01275	COG1199	ATP-dependent helicase activity
HVX45_01280	COG1214	PFAM Peptidase M22, glycoprotease
HVX45_01285	COG3065	identical protein binding
HVX45_01290	COG0318	PFAM AMP-dependent synthetase and ligase
HVX45_01295	COG0349	Exonuclease involved in the 3' processing of various precursor tRNAs. Initiates hydrolysis at the 3'-terminus of an RNA molecule and releases 5'-mononucleotides
HVX45_01300	COG1376	ErfK ybiS ycfS ynhG family protein
HVX45_01300	COG1388	LysM domain
HVX45_01305	COG1197	Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site
HVX45_01310	COG4763	Acyl-transferase
HVX45_01315	COG4591	ABC-type transport system involved in lipoprotein release permease component
HVX45_01325	COG4591	ABC-type transport system involved in lipoprotein release permease component
HVX45_01335	COG0846	NAD-dependent lysine deacetylase and desuccinylase that specifically removes acetyl and succinyl groups on target proteins. Modulates the activities of several proteins which are inactive in their acylated form
HVX45_01340	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
HVX45_01350	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HVX45_01355	COG1177	transmembrane transport
HVX45_01390	COG3139	Protein of unknown function (DUF1315)
HVX45_01395	COG1335	isochorismatase
HVX45_01400	COG0252	asparaginase activity
HVX45_01410	COG0616	signal peptide processing
HVX45_01415	COG0778	Nitroreductase
HVX45_01425	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HVX45_01435	COG0443	Heat shock 70 kDa protein
HVX45_01455	COG0494	nUDIX hydrolase
HVX45_01460	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HVX45_01465	COG2897	thiosulfate sulfurtransferase activity
HVX45_01470	COG4136	ATPase activity
HVX45_01475	COG4135	transport system, permease component
HVX45_01480	COG4134	Bacterial extracellular solute-binding protein
HVX45_01485	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HVX45_01490	COG0398	Pfam SNARE associated Golgi protein
HVX45_01495	COG0398	Pfam SNARE associated Golgi protein
HVX45_01500	COG0708	Exodeoxyribonuclease III
HVX45_01530	COG3678	ATP-independent chaperone mediated protein folding
HVX45_01540	COG0322	excinuclease ABC activity
HVX45_01550	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HVX45_01555	COG1440	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HVX45_01560	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HVX45_01565	COG1447	Phosphotransferase system cellobiose-specific component IIA
HVX45_01570	COG2169	Transcriptional regulator
HVX45_01570	COG1917	Cupin 2, conserved barrel domain protein
HVX45_01575	COG1486	melibiose metabolic process
HVX45_01585	COG0753	catalase activity
HVX45_01600	COG1988	membrane-bound metal-dependent
HVX45_01605	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HVX45_01615	COG3001	Fructosamine kinase
HVX45_01625	COG1105	Belongs to the carbohydrate kinase PfkB family
HVX45_01630	COG3137	Salt-induced outer membrane protein
HVX45_01735	COG1961	COG1961 Site-specific recombinases, DNA invertase Pin homologs
HVX45_01750	COG5301	cellulose 1,4-beta-cellobiosidase activity
HVX45_01830	COG4695	Portal protein
HVX45_01900	COG4974	Belongs to the 'phage' integrase family
HVX45_01925	COG0791	NLP P60 protein
HVX45_01940	COG4256	Hemin uptake protein
HVX45_01945	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HVX45_01955	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HVX45_01955	COG0574	Belongs to the PEP-utilizing enzyme family
HVX45_01970	COG0628	permease
HVX45_01975	COG0277	FAD linked oxidase domain protein
HVX45_01975	COG0247	lactate metabolic process
HVX45_01980	COG2050	protein possibly involved in aromatic compounds catabolism
HVX45_01990	COG0316	Belongs to the HesB IscA family
HVX45_01995	COG0719	Fe-S assembly protein
HVX45_02000	COG0396	ATPase activity
HVX45_02005	COG0719	Fe-S assembly protein
HVX45_02020	COG1376	ErfK ybiS ycfS ynhG family protein
HVX45_02025	COG4238	major outer membrane lipoprotein
HVX45_02030	COG0469	pyruvate kinase activity
HVX45_02040	COG4529	Protein conserved in bacteria
HVX45_02065	COG0307	riboflavin synthase, alpha
HVX45_02070	COG2230	cyclopropane-fatty-acyl-phospholipid synthase
HVX45_02075	COG2814	Major facilitator Superfamily
HVX45_02080	COG0583	DNA-binding transcription factor activity
HVX45_02095	COG2814	Major facilitator Superfamily
HVX45_02100	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HVX45_02105	COG0791	NLP P60 protein
HVX45_02110	COG0278	Belongs to the glutaredoxin family. Monothiol subfamily
HVX45_02115	COG1201	RNA secondary structure unwinding
HVX45_02125	COG0346	lactoylglutathione lyase activity
HVX45_02130	COG1902	pentaerythritol trinitrate reductase activity
HVX45_02135	COG1309	transcriptional regulator
HVX45_02140	COG3313	Fe-S protein
HVX45_02145	COG4989	oxidoreductase activity
HVX45_02150	COG2032	superoxide dismutase activity
HVX45_02155	COG1289	transmembrane transporter activity
HVX45_02160	COG1566	PFAM secretion protein HlyD family protein
HVX45_02175	COG3133	Outer membrane lipoprotein
HVX45_02185	COG3895	Periplasmic Protein
HVX45_02205	COG0625	glutathione transferase activity
HVX45_02210	COG3104	oligopeptide transport
HVX45_02215	COG0177	DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N- glycosidic bond, leaving an AP (apurinic apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate
HVX45_02225	COG4659	FMN binding
HVX45_02265	COG0673	inositol 2-dehydrogenase activity
HVX45_02275	COG1168	Bifunctional PLP-dependent enzyme with beta-cystaTHIonase and maltose regulon repressor activities
HVX45_02280	COG5339	Protein conserved in bacteria
HVX45_02285	COG1482	cell wall glycoprotein biosynthetic process
HVX45_02290	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HVX45_02290	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
HVX45_02295	COG0114	fumarate hydratase activity
HVX45_02305	COG2205	protein histidine kinase activity
HVX45_02310	COG0745	RESPONSE REGULATOR receiver
HVX45_02315	COG3136	membrane protein required for alginate biosynthesis
HVX45_02325	COG0531	amino acid
HVX45_02335	COG3288	NAD(P)+ transhydrogenase (AB-specific) activity
HVX45_02340	COG1282	The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane
HVX45_02350	COG3591	Belongs to the peptidase S1B family
HVX45_02365	COG2814	Major facilitator Superfamily
HVX45_02370	COG0583	DNA-binding transcription factor activity
HVX45_02375	COG1940	carbohydrate kinase activity
HVX45_02380	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HVX45_02415	COG3238	Protein conserved in bacteria
HVX45_02420	COG1247	-acetyltransferase
HVX45_02425	COG2130	NADP-dependent
HVX45_02430	COG1802	Transcriptional regulator
HVX45_02435	COG4772	TonB-dependent receptor
HVX45_02440	COG3391	amine dehydrogenase activity
HVX45_02445	COG1113	amino acid transport
HVX45_02450	COG0625	glutathione transferase activity
HVX45_02460	COG5433	transposase activity
HVX45_02525	COG0384	phenazine biosynthesis protein PhzF
HVX45_02535	COG1609	Transcriptional regulator
HVX45_02545	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HVX45_02550	COG2162	N-hydroxyarylamine O-acetyltransferase activity
HVX45_02555	COG1414	Transcriptional regulator
HVX45_02560	COG4948	Mandelate Racemase Muconate Lactonizing
HVX45_02565	COG4829	muconolactone delta-isomerase
HVX45_02570	COG3485	protocatechuate 3,4-dioxygenase
HVX45_02605	COG0697	spore germination
HVX45_02615	COG0437	4 iron, 4 sulfur cluster binding
HVX45_02620	COG2864	formate dehydrogenase
HVX45_02625	COG3093	addiction module antidote protein HigA
HVX45_02635	COG1064	alcohol dehydrogenase
HVX45_02655	COG1764	response to oxidative stress
HVX45_02665	COG0583	DNA-binding transcription factor activity
HVX45_02670	COG3485	protocatechuate 3,4-dioxygenase
HVX45_02675	COG3485	protocatechuate 3,4-dioxygenase
HVX45_02680	COG5383	Protein conserved in bacteria
HVX45_02690	COG2841	Protein conserved in bacteria
HVX45_02695	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HVX45_02700	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HVX45_02705	COG0500	methyltransferase
HVX45_02715	COG0826	peptidase U32
HVX45_02730	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HVX45_02735	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HVX45_02740	COG3842	ATPase activity
HVX45_02745	COG1176	ABC-type spermidine putrescine transport system, permease component I
HVX45_02750	COG1177	transmembrane transport
HVX45_02780	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HVX45_02795	COG4948	Mandelate Racemase Muconate Lactonizing
HVX45_02800	COG1063	alcohol dehydrogenase
HVX45_02805	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HVX45_02815	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HVX45_02820	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HVX45_02825	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HVX45_02825	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
HVX45_02835	COG0246	Mannitol dehydrogenase
HVX45_02845	COG1802	Transcriptional regulator
HVX45_02850	COG4221	oxidoreductase activity
HVX45_02855	COG0339	signal peptide processing
HVX45_02860	COG1546	Belongs to the CinA family
HVX45_02865	COG3111	PFAM Bacterial OB fold (BOF) protein
HVX45_02870	COG3706	GGDEF domain
HVX45_02875	COG2814	Major facilitator Superfamily
HVX45_02880	COG0697	spore germination
HVX45_02890	COG4977	sequence-specific DNA binding
HVX45_02895	COG1846	Transcriptional regulator
HVX45_02910	COG0583	DNA-binding transcription factor activity
HVX45_02915	COG1012	belongs to the aldehyde dehydrogenase family
HVX45_02920	COG2066	Belongs to the glutaminase family
HVX45_02930	COG2199	diguanylate cyclase activity
HVX45_02940	COG3781	membrane
HVX45_02950	COG0675	Transposase, IS605 OrfB family
HVX45_03005	COG2207	Transcriptional regulator
HVX45_03030	COG4771	TonB-dependent receptor
HVX45_03035	COG0612	Peptidase, M16
HVX45_03040	COG0076	glutamate decarboxylase activity
HVX45_03045	COG0531	amino acid
HVX45_03055	COG3706	GGDEF domain
HVX45_03060	COG2199	diguanylate cyclase activity
HVX45_03060	COG2202	Pas domain
HVX45_03060	COG2200	EAL domain
HVX45_03075	COG3038	cytochrome b561
HVX45_03080	COG0057	glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
HVX45_03085	COG1434	Gram-negative-bacterium-type cell wall biogenesis
HVX45_03095	COG1643	Atp-dependent helicase
HVX45_03105	COG0671	phosphoesterase, PA-phosphatase related
HVX45_03105	COG2453	phosphatase
HVX45_03110	COG2267	carboxylic ester hydrolase activity
HVX45_03115	COG4589	Belongs to the CDS family
HVX45_03120	COG0558	Belongs to the CDP-alcohol phosphatidyltransferase class-I family
HVX45_03130	COG0667	Aldo Keto reductase
HVX45_03135	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HVX45_03140	COG3327	negative regulation of DNA-templated transcription, initiation
HVX45_03145	COG1541	Catalyzes the activation of phenylacetic acid (PA) to phenylacetyl-CoA (PA-CoA)
HVX45_03150	COG0183	Belongs to the thiolase family
HVX45_03155	COG2050	protein possibly involved in aromatic compounds catabolism
HVX45_03160	COG1250	3-hydroxyacyl-CoA dehydrogenase
HVX45_03165	COG1024	Enoyl-CoA hydratase
HVX45_03170	COG1024	Enoyl-CoA hydratase
HVX45_03175	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HVX45_03180	COG2151	metal-sulfur cluster biosynthetic enzyme
HVX45_03185	COG3396	Phenylacetate-CoA oxygenase
HVX45_03190	COG3460	Phenylacetate-CoA oxygenase
HVX45_03195	COG3396	Phenylacetate-CoA oxygenase
HVX45_03200	COG1012	belongs to the aldehyde dehydrogenase family
HVX45_03200	COG2030	dehydratase
HVX45_03205	COG3733	amine oxidase
HVX45_03210	COG1012	belongs to the aldehyde dehydrogenase family
HVX45_03215	COG2207	Transcriptional regulator
HVX45_03225	COG3784	Protein of unknown function (DUF1318)
HVX45_03235	COG2911	Protein conserved in bacteria
HVX45_03240	COG1052	Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family
HVX45_03245	COG3187	Heat shock protein
HVX45_03250	COG3042	response to heat
HVX45_03260	COG0674	pyruvate-flavodoxin oxidoreductase activity
HVX45_03260	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HVX45_03260	COG1013	pyruvate-flavodoxin oxidoreductase activity
HVX45_03260	COG1014	Oxidoreductase required for the transfer of electrons from pyruvate to flavodoxin
HVX45_03265	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HVX45_03270	COG0589	response to stress
HVX45_03280	COG0513	Belongs to the DEAD box helicase family
HVX45_03295	COG3706	GGDEF domain
HVX45_03300	COG0599	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HVX45_03305	COG0596	Alpha beta hydrolase
HVX45_03315	COG0183	Belongs to the thiolase family
HVX45_03320	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HVX45_03330	COG1414	Transcriptional regulator
HVX45_03335	COG2840	Smr protein MutS2
HVX45_03340	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HVX45_03345	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HVX45_03350	COG0589	response to stress
HVX45_03355	COG3182	Iron-regulated membrane protein
HVX45_03360	COG0668	transmembrane transport
HVX45_03365	COG4166	transmembrane transport
HVX45_03370	COG2866	Carboxypeptidase
HVX45_03375	COG4948	Mandelate Racemase Muconate Lactonizing
HVX45_03380	COG2077	Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides
HVX45_03385	COG3283	Transcriptional regulator of aromatic amino acids metabolism
HVX45_03395	COG3106	COG3106 Predicted ATPase
HVX45_03400	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HVX45_03410	COG1983	PspC domain protein
HVX45_03420	COG1842	Phage shock protein A
HVX45_03425	COG1221	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain
HVX45_03430	COG4166	transmembrane transport
HVX45_03435	COG4168	peptide transport system, permease
HVX45_03440	COG4171	peptide transport system, permease
HVX45_03445	COG4172	Belongs to the ABC transporter superfamily
HVX45_03450	COG4172	Belongs to the ABC transporter superfamily
HVX45_03455	COG0623	enoyl-[acyl-carrier-protein] reductase (NADH) activity
HVX45_03460	COG4950	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HVX45_03460	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HVX45_03470	COG5001	Diguanylate cyclase
HVX45_03480	COG1349	DNA-binding transcription factor activity
HVX45_03490	COG0023	Translation Initiation Factor
HVX45_03500	COG2956	Modulates cellular lipopolysaccharide (LPS) levels by regulating LpxC, which is involved in lipid A biosynthesis. May act by modulating the proteolytic activity of FtsH towards LpxC. May also coordinate assembly of proteins involved in LPS synthesis at the plasma membrane
HVX45_03505	COG3771	Involved in the assembly of lipopolysaccharide (LPS)
HVX45_03510	COG0671	phosphoesterase, PA-phosphatase related
HVX45_03540	COG0550	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone
HVX45_03550	COG0616	signal peptide processing
HVX45_03555	COG1028	Short-chain dehydrogenase reductase Sdr
HVX45_03560	COG2109	Required for both de novo synthesis of the corrin ring for the assimilation of exogenous corrinoids. Participates in the adenosylation of a variety of incomplete and complete corrinoids
HVX45_03565	COG1187	pseudouridine synthase activity
HVX45_03570	COG4907	membrane protein (DUF2207)
HVX45_03575	COG0009	L-threonylcarbamoyladenylate synthase
HVX45_03580	COG0613	PHP domain protein
HVX45_03590	COG0147	Part of a heterotetrameric complex that catalyzes the two-step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine- binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentrations of ammonia
HVX45_03595	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HVX45_03595	COG0512	Glutamine amidotransferase of anthranilate synthase
HVX45_03600	COG0134	indole-3-glycerol-phosphate synthase activity
HVX45_03600	COG0135	phosphoribosylanthranilate isomerase activity
HVX45_03615	COG3047	cAMP biosynthetic process
HVX45_03620	COG0727	PFAM Uncharacterised protein family (UPF0153)
HVX45_03635	COG1607	acyl-coa hydrolase
HVX45_03645	COG2350	Protein conserved in bacteria
HVX45_03670	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HVX45_03675	COG4608	Belongs to the ABC transporter superfamily
HVX45_03680	COG0444	Belongs to the ABC transporter superfamily
HVX45_03700	COG2095	MarC family integral membrane protein
HVX45_03705	COG1012	belongs to the aldehyde dehydrogenase family
HVX45_03705	COG1454	alcohol dehydrogenase
HVX45_03715	COG1435	thymidine kinase activity
HVX45_03725	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HVX45_03730	COG0745	RESPONSE REGULATOR receiver
HVX45_03735	COG1752	Esterase of the alpha-beta hydrolase superfamily
HVX45_03745	COG0788	formyltetrahydrofolate deformylase activity
HVX45_03790	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HVX45_03795	COG0332	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids
HVX45_03800	COG2181	nitrate reductase activity
HVX45_03805	COG2180	nitrate reductase molybdenum cofactor assembly chaperone
HVX45_03810	COG1140	nitrate reductase beta subunit
HVX45_03815	COG5013	Belongs to the prokaryotic molybdopterin-containing oxidoreductase family
HVX45_03820	COG2223	nitrite transmembrane transporter activity
HVX45_03825	COG3850	Histidine kinase
HVX45_03830	COG2197	response regulator
HVX45_03835	COG4932	domain protein
HVX45_03840	COG1553	Part of a sulfur-relay system required for 2-thiolation of 5-methylaminomethyl-2-thiouridine (mnm(5)s(2)U) at tRNA wobble positions. Accepts sulfur from TusA and transfers it in turn to TusE
HVX45_03845	COG3703	Catalyzes the cleavage of glutathione into 5-oxo-L- proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides
HVX45_03850	COG4572	Cation transport regulator
HVX45_03855	COG0387	Pfam Sodium calcium exchanger
HVX45_03875	COG2890	protein-(glutamine-N5) methyltransferase activity
HVX45_03900	COG0462	Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P)
HVX45_03905	COG0659	secondary active sulfate transmembrane transporter activity
HVX45_03920	COG0012	GTP binding
HVX45_03935	COG5581	Acts as a flagellar brake, regulating swimming and swarming in a bis-(3'-5') cyclic diguanylic acid (c-di-GMP)- dependent manner. Binds 1 c-di-GMP dimer per subunit. Increasing levels of c-di-GMP lead to decreased motility
HVX45_03945	COG1619	proteins homologs of microcin C7 resistance protein MccF
HVX45_03955	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HVX45_03965	COG2719	SpoVR family
HVX45_03980	COG1495	Required for disulfide bond formation in some periplasmic proteins. Acts by oxidizing the DsbA protein
HVX45_03985	COG1388	LysM domain
HVX45_03985	COG1470	cell adhesion involved in biofilm formation
HVX45_03995	COG0179	Fumarylacetoacetate (FAA) hydrolase
HVX45_04010	COG2894	cell division
HVX45_04020	COG1124	(ABC) transporter
HVX45_04030	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HVX45_04035	COG0601	transmembrane transport
HVX45_04040	COG0747	negative chemotaxis
HVX45_04055	COG1473	amidohydrolase
HVX45_04075	COG0217	transcriptional regulatory protein
HVX45_04085	COG4932	domain protein
HVX45_04085	COG1388	LysM domain
HVX45_04085	COG2373	Large extracellular alpha-helical protein
HVX45_04100	COG0582	viral genome integration into host DNA
HVX45_04105	COG0538	isocitrate dehydrogenase activity
HVX45_04110	COG1187	pseudouridine synthase activity
HVX45_04130	COG0015	Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily
HVX45_04135	COG0745	RESPONSE REGULATOR receiver
HVX45_04140	COG2205	protein histidine kinase activity
HVX45_04145	COG2850	peptidyl-arginine hydroxylation
HVX45_04150	COG0656	L-ascorbic acid biosynthetic process
HVX45_04155	COG3713	MltA-interacting MipA family protein
HVX45_04160	COG2766	serine protein kinase
HVX45_04170	COG2199	diguanylate cyclase activity
HVX45_04175	COG2199	diguanylate cyclase activity
HVX45_04180	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HVX45_04195	COG2807	transmembrane transport
HVX45_04200	COG3189	MarR family transcriptional regulator
HVX45_04205	COG3042	response to heat
HVX45_04210	COG2203	Gaf domain
HVX45_04210	COG2199	diguanylate cyclase activity
HVX45_04225	COG2261	transglycosylase associated protein
HVX45_04235	COG3134	Outer membrane lipoprotein
HVX45_04240	COG1252	NADH dehydrogenase
HVX45_04255	COG0510	thiamine kinase activity
HVX45_04260	COG3417	Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b)
HVX45_04265	COG5633	Lipoprotein
HVX45_04270	COG0537	adenosine 5'-monophosphoramidase activity
HVX45_04280	COG0084	hydrolase, TatD family'
HVX45_04285	COG0470	DNA polymerase III
HVX45_04295	COG1559	Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation
HVX45_04300	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HVX45_04305	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HVX45_04315	COG1028	Short-chain dehydrogenase reductase Sdr
HVX45_04320	COG0331	[acyl-carrier-protein] S-malonyltransferase activity
HVX45_04340	COG1399	metal-binding, possibly nucleic acid-binding protein
HVX45_04345	COG0424	maF-like protein
HVX45_04350	COG0564	pseudouridine synthase activity
HVX45_04355	COG1530	ribonuclease E activity
HVX45_04360	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HVX45_04365	COG1256	bacterial-type flagellum assembly
HVX45_04370	COG1705	Flagellar rod assembly protein muramidase FlgJ
HVX45_04370	COG3951	Flagellar rod assembly protein muramidase FlgJ
HVX45_04390	COG4787	bacterial-type flagellum-dependent cell motility
HVX45_04395	COG1749	Flagellar hook protein flgE
HVX45_04400	COG1843	Required for flagellar hook formation. May act as a scaffolding protein
HVX45_04405	COG1558	bacterial-type flagellum-dependent cell motility
HVX45_04420	COG2747	anti-sigma28 factor FlgM
HVX45_04430	COG0728	peptidoglycan biosynthetic process
HVX45_04435	COG0673	inositol 2-dehydrogenase activity
HVX45_04445	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HVX45_04480	COG3038	cytochrome b561
HVX45_04485	COG2353	YceI-like domain
HVX45_04495	COG1560	Kdo2-lipid A biosynthetic process
HVX45_04510	COG5645	(Lipo)protein
HVX45_04515	COG2943	transferase activity, transferring hexosyl groups
HVX45_04530	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HVX45_04575	COG1462	curli production assembly transport component CsgG
HVX45_04585	COG3381	protein complex oligomerization
HVX45_04605	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HVX45_04610	COG3104	oligopeptide transport
HVX45_04615	COG1982	Orn Lys Arg decarboxylase major
HVX45_04620	COG0531	amino acid
HVX45_04625	COG3710	Transcriptional regulator
HVX45_04630	COG3706	GGDEF domain
HVX45_04635	COG0457	Tetratricopeptide repeat
HVX45_04640	COG1649	PFAM Uncharacterised BCR, COG1649
HVX45_04640	COG0726	polysaccharide deacetylase
HVX45_04645	COG1215	transferase activity, transferring glycosyl groups
HVX45_04650	COG3658	cytochrome
HVX45_04655	COG1702	phosphate starvation-inducible protein PhoH
HVX45_04665	COG2822	iron ion transport
HVX45_04675	COG0591	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HVX45_04685	COG0506	proline dehydrogenase activity
HVX45_04685	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HVX45_04685	COG4230	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HVX45_04690	COG1560	Kdo2-lipid A biosynthetic process
HVX45_04695	COG2990	Protein conserved in bacteria
HVX45_04700	COG0438	transferase activity, transferring glycosyl groups
HVX45_04705	COG0726	polysaccharide deacetylase
HVX45_04710	COG0389	Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII
HVX45_04715	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HVX45_04725	COG1766	The M ring may be actively involved in energy transduction
HVX45_04730	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HVX45_04735	COG1317	bacterial-type flagellum organization
HVX45_04740	COG1157	protein secretion by the type III secretion system
HVX45_04745	COG2882	bacterial-type flagellum organization
HVX45_04750	COG3144	bacterial-type flagellum assembly
HVX45_04755	COG1580	Controls the rotational direction of flagella during chemotaxis
HVX45_04760	COG1868	FliM is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HVX45_04765	COG1886	FliN is one of three proteins (FliG, FliN, FliM) that form the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HVX45_04770	COG3190	flagellar
HVX45_04775	COG1338	Plays a role in the flagellum-specific transport system
HVX45_04790	COG2197	response regulator
HVX45_04815	COG5475	Uncharacterized small protein (DUF2158)
HVX45_04820	COG2354	Protein conserved in bacteria
HVX45_04825	COG0697	spore germination
HVX45_04830	COG3727	T/G mismatch-specific endonuclease activity
HVX45_04835	COG1418	mRNA catabolic process
HVX45_04845	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HVX45_04855	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HVX45_04880	COG0583	DNA-binding transcription factor activity
HVX45_04925	COG3157	Type VI secretion system effector, Hcp
HVX45_05005	COG3501	Rhs element vgr protein
HVX45_05015	COG3209	COG3209 Rhs family protein
HVX45_05025	COG5433	transposase activity
HVX45_05045	COG0775	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively
HVX45_05050	COG0477	Major facilitator Superfamily
HVX45_05060	COG0534	Mate efflux family protein
HVX45_05100	COG1012	belongs to the aldehyde dehydrogenase family
HVX45_05100	COG1454	alcohol dehydrogenase
HVX45_05110	COG1012	belongs to the aldehyde dehydrogenase family
HVX45_05110	COG1454	alcohol dehydrogenase
HVX45_05115	COG1882	Formate acetyltransferase
HVX45_05120	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HVX45_05130	COG4869	propanediol catabolic process
HVX45_05150	COG1376	ErfK ybiS ycfS ynhG family protein
HVX45_05245	COG4656	Part of a membrane complex involved in electron transport
HVX45_05275	COG1289	transmembrane transporter activity
HVX45_05285	COG2925	Exonuclease
HVX45_05290	COG0425	Belongs to the sulfur carrier protein TusA family
HVX45_05295	COG2391	methyltransferase activity
HVX45_05300	COG0531	amino acid
HVX45_05310	COG0583	DNA-binding transcription factor activity
HVX45_05315	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HVX45_05320	COG4115	mRNA cleavage
HVX45_05325	COG2161	toxin-antitoxin pair type II binding
HVX45_05340	COG0141	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine
HVX45_05350	COG0131	Imidazoleglycerol-phosphate dehydratase
HVX45_05350	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HVX45_05355	COG0118	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR
HVX45_05385	COG0362	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH
HVX45_05400	COG0297	glycogen (starch) synthase activity
HVX45_05425	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
HVX45_05440	COG1210	Utp--glucose-1-phosphate uridylyltransferase
HVX45_05445	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HVX45_05455	COG0438	transferase activity, transferring glycosyl groups
HVX45_05460	COG2327	Polysaccharide pyruvyl transferase
HVX45_05465	COG2244	polysaccharide biosynthetic process
HVX45_05470	COG2148	undecaprenyl-phosphate glucose phosphotransferase activity
HVX45_05475	COG1109	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
HVX45_05480	COG0836	Belongs to the mannose-6-phosphate isomerase type 2 family
HVX45_05480	COG0662	Cupin 2, conserved barrel domain protein
HVX45_05485	COG0297	glycogen (starch) synthase activity
HVX45_05490	COG1051	belongs to the nudix hydrolase family
HVX45_05495	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HVX45_05500	COG1089	Catalyzes the conversion of GDP-D-mannose to GDP-4- dehydro-6-deoxy-D-mannose
HVX45_05505	COG0110	maltose O-acetyltransferase activity
HVX45_05510	COG1216	Glycosyl transferase, family 2
HVX45_05520	COG0438	transferase activity, transferring glycosyl groups
HVX45_05525	COG1045	serine acetyltransferase
HVX45_05530	COG0463	Glycosyl transferase, family 2
HVX45_05535	COG0489	protein tyrosine kinase activity
HVX45_05535	COG3206	protein involved in exopolysaccharide biosynthesis
HVX45_05540	COG0394	Belongs to the low molecular weight phosphotyrosine protein phosphatase family
HVX45_05545	COG1596	polysaccharide export
HVX45_05555	COG1253	flavin adenine dinucleotide binding
HVX45_05575	COG2982	Protein involved in outer membrane biogenesis
HVX45_05590	COG3447	MASE1 domain protein
HVX45_05590	COG5001	Diguanylate cyclase
HVX45_05590	COG5002	protein histidine kinase activity
HVX45_05595	COG0122	3-methyladenine DNA glycosylase 8-oxoguanine DNA glycosylase
HVX45_05600	COG0443	Heat shock 70 kDa protein
HVX45_05605	COG4248	protein with protein kinase and helix-hairpin-helix DNA-binding domains
HVX45_05610	COG3779	Protein conserved in bacteria
HVX45_05615	COG0631	protein serine/threonine phosphatase activity
HVX45_05620	COG4245	von Willebrand factor, type A
HVX45_05655	COG2205	protein histidine kinase activity
HVX45_05660	COG0745	RESPONSE REGULATOR receiver
HVX45_05670	COG3609	addiction module antidote protein, CC2985 family
HVX45_05690	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HVX45_05700	COG1070	Carbohydrate kinase
HVX45_05725	COG1069	ribulokinase activity
HVX45_05735	COG1830	Aldolase
HVX45_05740	COG2211	Major facilitator Superfamily
HVX45_05745	COG1397	ADP-ribosylglycohydrolase
HVX45_05750	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HVX45_05755	COG2188	Transcriptional regulator
HVX45_05760	COG3757	hydrolase, family 25
HVX45_05765	COG0351	phosphomethylpyrimidine kinase
HVX45_05775	COG5455	response to cobalt ion
HVX45_05780	COG3539	Fimbrial protein
HVX45_05785	COG3188	usher protein
HVX45_05790	COG3121	Chaperone
HVX45_05805	COG0489	protein tyrosine kinase activity
HVX45_05815	COG3831	ATPase activity
HVX45_05820	COG3831	ATPase activity
HVX45_05825	COG3831	ATPase activity
HVX45_05830	COG3831	ATPase activity
HVX45_05840	COG0714	Associated with various cellular activities
HVX45_05845	COG2425	protein containing a von Willebrand factor type A (vWA) domain
HVX45_05850	COG3552	Protein containing von Willebrand factor type A (VWA) domain
HVX45_05855	COG4715	Zinc finger, swim domain protein
HVX45_05860	COG4808	Protein conserved in bacteria
HVX45_05865	COG4807	Protein conserved in bacteria
HVX45_05875	COG3275	phosphorelay sensor kinase activity
HVX45_05880	COG0789	Transcriptional regulator
HVX45_05890	COG1174	glycine betaine transport
HVX45_05895	COG1125	glycine betaine transport
HVX45_05900	COG1174	glycine betaine transport
HVX45_05905	COG1732	Glycine betaine
HVX45_05910	COG1472	Belongs to the glycosyl hydrolase 3 family
HVX45_05915	COG0277	FAD linked oxidase domain protein
HVX45_05920	COG1686	Belongs to the peptidase S11 family
HVX45_05930	COG0586	Pfam SNARE associated Golgi protein
HVX45_05935	COG1028	Short-chain dehydrogenase reductase Sdr
HVX45_05945	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HVX45_05955	COG1346	cytolysis
HVX45_05965	COG2949	membrane
HVX45_05975	COG0493	'glutamate synthase
HVX45_05980	COG1146	Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions
HVX45_05980	COG0167	dihydroorotate dehydrogenase activity
HVX45_05985	COG4211	Belongs to the binding-protein-dependent transport system permease family
HVX45_05990	COG1129	ABC transporter
HVX45_05995	COG1879	ABC-type sugar transport system periplasmic component
HVX45_06000	COG1609	Transcriptional regulator
HVX45_06005	COG2311	Membrane
HVX45_06020	COG4771	TonB-dependent receptor
HVX45_06025	COG0833	amino acid
HVX45_06030	COG0583	DNA-binding transcription factor activity
HVX45_06035	COG2855	membrane
HVX45_06045	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HVX45_06045	COG1522	sequence-specific DNA binding
HVX45_06050	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HVX45_06060	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HVX45_06065	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HVX45_06070	COG2313	pseudouridylate synthase activity
HVX45_06075	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HVX45_06080	COG3925	protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
HVX45_06080	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HVX45_06080	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HVX45_06085	COG1105	Belongs to the carbohydrate kinase PfkB family
HVX45_06090	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HVX45_06090	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HVX45_06110	COG0246	Mannitol dehydrogenase
HVX45_06115	COG0523	cobalamin synthesis protein
HVX45_06120	COG0671	phosphoesterase, PA-phosphatase related
HVX45_06125	COG0791	NLP P60 protein
HVX45_06130	COG2200	EAL domain
HVX45_06135	COG4166	transmembrane transport
HVX45_06140	COG4174	ABC transporter (Permease)
HVX45_06145	COG4239	(ABC) transporter, permease
HVX45_06150	COG4172	Belongs to the ABC transporter superfamily
HVX45_06160	COG2814	Major facilitator Superfamily
HVX45_06165	COG1187	pseudouridine synthase activity
HVX45_06170	COG1061	Type III restriction enzyme res subunit
HVX45_06180	COG0596	Alpha beta hydrolase
HVX45_06195	COG3083	sulfuric ester hydrolase activity
HVX45_06215	COG2197	response regulator
HVX45_06220	COG3088	subunit of a heme lyase
HVX45_06220	COG4235	cytochrome complex assembly
HVX45_06225	COG0526	COG0526, thiol-disulfide isomerase and thioredoxins
HVX45_06230	COG1138	Cytochrome C-type biogenesis protein
HVX45_06240	COG3114	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HVX45_06245	COG0755	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HVX45_06250	COG2386	Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes
HVX45_06255	COG4133	protoheme IX ABC transporter activity
HVX45_06260	COG3005	denitrification pathway
HVX45_06265	COG3043	anaerobic respiration
HVX45_06270	COG0348	domain, Protein
HVX45_06275	COG0437	4 iron, 4 sulfur cluster binding
HVX45_06285	COG3062	negative regulation of establishment of protein localization
HVX45_06290	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HVX45_06290	COG1149	4fe-4S ferredoxin, iron-sulfur binding domain protein
HVX45_06300	COG0668	transmembrane transport
HVX45_06315	COG4774	siderophore transport
HVX45_06325	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HVX45_06335	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
HVX45_06340	COG0547	Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA)
HVX45_06345	COG1199	ATP-dependent helicase activity
HVX45_06350	COG0513	Belongs to the DEAD box helicase family
HVX45_06355	COG1309	transcriptional regulator
HVX45_06365	COG1131	(ABC) transporter
HVX45_06370	COG0842	Transport permease protein
HVX45_06375	COG0842	Transport permease protein
HVX45_06385	COG3568	Endonuclease Exonuclease Phosphatase
HVX45_06390	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HVX45_06395	COG0392	lysyltransferase activity
HVX45_06400	COG0670	Belongs to the BI1 family
HVX45_06405	COG2194	sulfuric ester hydrolase activity
HVX45_06410	COG0670	Belongs to the BI1 family
HVX45_06415	COG0314	molybdopterin synthase activity
HVX45_06420	COG1977	Involved in sulfur transfer in the conversion of molybdopterin precursor Z to molybdopterin
HVX45_06430	COG0521	Mo-molybdopterin cofactor biosynthetic process
HVX45_06440	COG0391	Required for morphogenesis under gluconeogenic growth conditions
HVX45_06450	COG0132	Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8-diaminopelargonic acid (DAPA) to form an ureido ring
HVX45_06455	COG2226	methyltransferase
HVX45_06470	COG0161	adenosylmethionine-8-amino-7-oxononanoate transaminase activity
HVX45_06475	COG1881	PFAM PEBP family protein
HVX45_06480	COG2246	polysaccharide biosynthetic process
HVX45_06485	COG0463	Glycosyl transferase, family 2
HVX45_06585	COG1783	phage Terminase large subunit
HVX45_06605	COG3646	Phage regulatory protein
HVX45_06805	COG0582	viral genome integration into host DNA
HVX45_06810	COG4677	pectinesterase activity
HVX45_06820	COG0561	phosphatase activity
HVX45_06830	COG4149	molybdate abc transporter
HVX45_06835	COG0725	ABC transporter, periplasmic molybdate-binding protein
HVX45_06845	COG3585	molybdate ion transport
HVX45_06845	COG2005	Transcriptional regulator
HVX45_06850	COG1119	ATPase activity
HVX45_06855	COG1087	Belongs to the NAD(P)-dependent epimerase dehydratase family
HVX45_06860	COG1085	galactose-1-phosphate uridylyltransferase
HVX45_06870	COG2017	converts alpha-aldose to the beta-anomer
HVX45_06880	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HVX45_06890	COG1230	cation diffusion facilitator family transporter
HVX45_06895	COG3201	nicotinamide mononucleotide transporter
HVX45_06940	COG1729	Mediates coordination of peptidoglycan synthesis and outer membrane constriction during cell division
HVX45_06945	COG2885	chlorophyll binding
HVX45_06955	COG3064	Membrane
HVX45_06960	COG0848	biopolymer transport protein
HVX45_06965	COG0811	peptide transport
HVX45_06970	COG0824	Thioesterase
HVX45_06975	COG3790	cyd operon protein YbgE
HVX45_06980	COG4890	Cyd operon protein YbgT
HVX45_06985	COG1294	oxidase, subunit
HVX45_06990	COG1271	oxidase subunit
HVX45_06995	COG0383	alpha-mannosidase activity
HVX45_07000	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HVX45_07000	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HVX45_07000	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HVX45_07005	COG2188	Transcriptional regulator
HVX45_07010	COG2185	Catalyzes the reversible interconversion of isobutyryl- CoA and n-butyryl-CoA, using radical chemistry. Also exhibits GTPase activity, associated with its G-protein domain (MeaI) that functions as a chaperone that assists cofactor delivery and proper holo-enzyme assembly
HVX45_07020	COG4865	methylaspartate mutase activity
HVX45_07025	COG3799	methylaspartate ammonia-lyase activity
HVX45_07040	COG1301	dicarboxylic acid transport
HVX45_07045	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
HVX45_07045	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HVX45_07050	COG0583	DNA-binding transcription factor activity
HVX45_07055	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HVX45_07065	COG0508	dehydrogenase complex catalyzes the overall conversion of
HVX45_07070	COG0567	Dehydrogenase, E1 component
HVX45_07075	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HVX45_07080	COG1053	succinate dehydrogenase
HVX45_07085	COG2142	Succinate dehydrogenase hydrophobic membrane anchor
HVX45_07090	COG2009	succinate dehydrogenase
HVX45_07095	COG0372	Belongs to the citrate synthase family
HVX45_07100	COG3539	Fimbrial protein
HVX45_07105	COG3188	usher protein
HVX45_07110	COG3121	Chaperone
HVX45_07115	COG3539	Fimbrial protein
HVX45_07120	COG3180	Ammonia monooxygenase
HVX45_07145	COG1984	allophanate hydrolase subunit 2
HVX45_07150	COG2049	5-oxoprolinase (ATP-hydrolyzing) activity
HVX45_07155	COG0327	Belongs to the GTP cyclohydrolase I type 2 NIF3 family
HVX45_07165	COG0415	Belongs to the DNA photolyase family
HVX45_07170	COG3272	Protein of unknown function (DUF1722)
HVX45_07225	COG2205	protein histidine kinase activity
HVX45_07230	COG0745	RESPONSE REGULATOR receiver
HVX45_07235	COG1982	Orn Lys Arg decarboxylase major
HVX45_07240	COG0531	amino acid
HVX45_07245	COG0033	Phosphoglucomutase
HVX45_07250	COG3057	Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re- initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated
HVX45_07255	COG0596	Alpha beta hydrolase
HVX45_07265	COG0716	FMN binding
HVX45_07275	COG0735	belongs to the Fur family
HVX45_07295	COG2190	(PTS) system
HVX45_07295	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HVX45_07295	COG1263	PTS System
HVX45_07305	COG1820	Belongs to the metallo-dependent hydrolases superfamily. NagA family
HVX45_07310	COG1846	Transcriptional regulator
HVX45_07310	COG1940	carbohydrate kinase activity
HVX45_07315	COG0647	UMP catabolic process
HVX45_07320	COG0367	asparagine synthase
HVX45_07370	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HVX45_07380	COG1702	phosphate starvation-inducible protein PhoH
HVX45_07390	COG4535	Mg2 and Co2 transporter CorC
HVX45_07395	COG0815	Transfers the fatty acyl group on membrane lipoproteins
HVX45_07405	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HVX45_07410	COG0765	amino acid transport
HVX45_07415	COG0765	amino acid transport
HVX45_07420	COG1126	abc transporter atp-binding protein
HVX45_07430	COG0443	Heat shock 70 kDa protein
HVX45_07435	COG2214	Heat shock protein DnaJ domain protein
HVX45_07445	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
HVX45_07450	COG2214	Heat shock protein DnaJ domain protein
HVX45_07460	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
HVX45_07465	COG2888	peptidyl-tyrosine sulfation
HVX45_07480	COG1466	dna polymerase III delta subunit
HVX45_07490	COG0799	negative regulation of ribosome biogenesis
HVX45_07500	COG0768	penicillin binding
HVX45_07505	COG0772	Belongs to the SEDS family
HVX45_07510	COG0797	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HVX45_07515	COG1686	Belongs to the peptidase S11 family
HVX45_07540	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HVX45_07560	COG3069	C4-dicarboxylate transmembrane transporter activity
HVX45_07565	COG3719	Belongs to the RNase T2 family
HVX45_07570	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HVX45_07575	COG0589	response to stress
HVX45_07580	COG3634	alkyl hydroperoxide reductase activity
HVX45_07585	COG0450	alkyl hydroperoxide reductase
HVX45_07590	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HVX45_07595	COG0583	DNA-binding transcription factor activity
HVX45_07600	COG3969	phosphoadenosine phosphosulfate
HVX45_07605	COG1475	DNA binding
HVX45_07610	COG0436	Aminotransferase
HVX45_07615	COG0371	Dehydrogenase
HVX45_07620	COG2879	small protein
HVX45_07625	COG1966	Carbon starvation protein
HVX45_07630	COG2050	protein possibly involved in aromatic compounds catabolism
HVX45_07635	COG1028	Short-chain dehydrogenase reductase Sdr
HVX45_07640	COG3433	isochorismatase activity
HVX45_07640	COG1535	isochorismatase
HVX45_07645	COG1021	2,3-dihydroxybenzoate-AMP ligase
HVX45_07650	COG1169	isochorismate synthase
HVX45_07655	COG4592	Periplasmic binding protein
HVX45_07665	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HVX45_07670	COG4779	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HVX45_07675	COG1120	ATPase activity
HVX45_07680	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
HVX45_07685	COG1020	D-alanine [D-alanyl carrier protein] ligase activity
HVX45_07685	COG3319	amino acid activation for nonribosomal peptide biosynthetic process
HVX45_07690	COG3251	PFAM MbtH domain protein
HVX45_07695	COG2382	esterase
HVX45_07700	COG4771	TonB-dependent receptor
HVX45_07705	COG2977	Belongs to the P-Pant transferase superfamily
HVX45_07710	COG3958	Transketolase
HVX45_07715	COG3959	Transketolase, thiamine diphosphate binding domain
HVX45_07720	COG2390	Transcriptional regulator
HVX45_07725	COG0554	Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn- glycerol 3-phosphate
HVX45_07730	COG1879	ABC-type sugar transport system periplasmic component
HVX45_07740	COG1129	ABC transporter
HVX45_07745	COG1172	Belongs to the binding-protein-dependent transport system permease family
HVX45_07755	COG1028	Short-chain dehydrogenase reductase Sdr
HVX45_07775	COG2315	Protein conserved in bacteria
HVX45_07780	COG0778	Nitroreductase
HVX45_07785	COG0668	transmembrane transport
HVX45_07790	COG1113	amino acid transport
HVX45_07795	COG3696	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HVX45_07800	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HVX45_07805	COG5569	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HVX45_07810	COG1538	Outer membrane efflux protein
HVX45_07815	COG0745	RESPONSE REGULATOR receiver
HVX45_07820	COG5002	protein histidine kinase activity
HVX45_07855	COG2812	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity
HVX45_07865	COG2832	Protein of unknown function (DUF454)
HVX45_07870	COG3923	Primosomal replication protein n
HVX45_07880	COG3264	Mechanosensitive ion channel
HVX45_07880	COG1196	nuclear chromosome segregation
HVX45_07885	COG1309	transcriptional regulator
HVX45_07890	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HVX45_07895	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HVX45_07915	COG4943	cyclic-guanylate-specific phosphodiesterase activity
HVX45_07920	COG5507	3-demethylubiquinone-9 3-methyltransferase
HVX45_07930	COG3695	enzyme binding
HVX45_07935	COG3126	Type III secretion system lipoprotein chaperone (YscW)
HVX45_07940	COG1946	Acyl-CoA thioesterase
HVX45_07945	COG0004	ammonium transporteR
HVX45_07950	COG0347	Belongs to the P(II) protein family
HVX45_07955	COG1132	(ABC) transporter
HVX45_07960	COG1132	(ABC) transporter
HVX45_07965	COG1522	sequence-specific DNA binding
HVX45_07975	COG4533	DNA binding
HVX45_07985	COG0824	Thioesterase
HVX45_07990	COG1555	photosystem II stabilization
HVX45_07995	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HVX45_08000	COG0776	regulation of translation
HVX45_08005	COG0466	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner
HVX45_08025	COG0271	Belongs to the BolA IbaG family
HVX45_08030	COG3056	Lipoprotein
HVX45_08035	COG2223	nitrite transmembrane transporter activity
HVX45_08040	COG1622	oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor
HVX45_08045	COG0843	Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B
HVX45_08050	COG1845	cytochrome c oxidase, subunit III
HVX45_08055	COG3125	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor
HVX45_08075	COG1414	Transcriptional regulator
HVX45_08080	COG0169	Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA)
HVX45_08110	COG2814	Major facilitator Superfamily
HVX45_08120	COG1893	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid
HVX45_08125	COG0693	protein deglycase activity
HVX45_08140	COG0142	geranyltranstransferase activity
HVX45_08150	COG0667	Aldo Keto reductase
HVX45_08155	COG1267	Lipid phosphatase which dephosphorylates phosphatidylglycerophosphate (PGP) to phosphatidylglycerol (PG)
HVX45_08175	COG0117	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HVX45_08175	COG1985	Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)- pyrimidinedione 5'-phosphate
HVX45_08185	COG4238	major outer membrane lipoprotein
HVX45_08190	COG3248	Nucleoside-binding outer membrane protein
HVX45_08200	COG0341	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HVX45_08205	COG0342	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA
HVX45_08210	COG1862	Preprotein translocase
HVX45_08230	COG0366	Alpha amylase catalytic
HVX45_08235	COG1113	amino acid transport
HVX45_08240	COG1114	Component of the transport system for branched-chain amino acids
HVX45_08245	COG5002	protein histidine kinase activity
HVX45_08255	COG0420	3'-5' exonuclease activity
HVX45_08260	COG0419	ATPase involved in DNA repair
HVX45_08265	COG1940	carbohydrate kinase activity
HVX45_08280	COG4126	flavin adenine dinucleotide binding
HVX45_08300	COG0345	Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline
HVX45_08305	COG3706	GGDEF domain
HVX45_08325	COG1181	Belongs to the D-alanine--D-alanine ligase family
HVX45_08345	COG1133	In Escherichia coli SbmA is involved in uptake of microcin J25
HVX45_08350	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HVX45_08355	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HVX45_08365	COG0113	porphobilinogen synthase activity
HVX45_08370	COG2175	clavaminate synthase activity
HVX45_08375	COG0600	ABC-type nitrate sulfonate bicarbonate transport system permease component
HVX45_08385	COG4521	taurine ABC transporter
HVX45_08390	COG2120	A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl- inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics
HVX45_08400	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HVX45_08405	COG2079	MmgE PrpD family protein
HVX45_08410	COG0372	Belongs to the citrate synthase family
HVX45_08415	COG2513	Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate
HVX45_08420	COG3829	transcription factor binding
HVX45_08430	COG1280	lysine exporter protein (LysE YggA)
HVX45_08435	COG3706	GGDEF domain
HVX45_08440	COG2186	Transcriptional regulator
HVX45_08445	COG1063	alcohol dehydrogenase
HVX45_08450	COG2271	Major facilitator Superfamily
HVX45_08455	COG2200	EAL domain
HVX45_08465	COG2200	EAL domain
HVX45_08465	COG2771	luxR family
HVX45_08470	COG0454	-acetyltransferase
HVX45_08475	COG0656	L-ascorbic acid biosynthetic process
HVX45_08480	COG0667	Aldo Keto reductase
HVX45_08505	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
HVX45_08510	COG5301	cellulose 1,4-beta-cellobiosidase activity
HVX45_08550	COG1196	nuclear chromosome segregation
HVX45_08600	COG1030	water channel activity
HVX45_08620	COG4220	transposase activity
HVX45_08630	COG5562	phage envelope protein
HVX45_08645	COG3772	lysozyme
HVX45_08655	COG2207	Transcriptional regulator
HVX45_08660	COG3272	Protein of unknown function (DUF1722)
HVX45_08680	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
HVX45_08795	COG0582	viral genome integration into host DNA
HVX45_08815	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HVX45_08835	COG2195	Cleaves the N-terminal amino acid of tripeptides
HVX45_08850	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
HVX45_08855	COG1690	Belongs to the RtcB family
HVX45_08860	COG0454	-acetyltransferase
HVX45_08875	COG1291	archaeal or bacterial-type flagellum-dependent cell motility
HVX45_08880	COG1191	sigma factor activity
HVX45_08905	COG1345	Required for morphogenesis and for the elongation of the flagellar filament by facilitating polymerization of the flagellin monomers at the tip of growing filament. Forms a capping structure, which prevents flagellin subunits (transported through the central channel of the flagellum) from leaking out without polymerization at the distal end
HVX45_08910	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HVX45_08925	COG1344	Flagellin is the subunit protein which polymerizes to form the filaments of bacterial flagella
HVX45_08950	COG4786	Flagellar basal body rod
HVX45_08955	COG4787	bacterial-type flagellum-dependent cell motility
HVX45_08960	COG1749	Flagellar hook protein flgE
HVX45_08970	COG1558	bacterial-type flagellum-dependent cell motility
HVX45_08975	COG1815	bacterial-type flagellum-dependent cell motility
HVX45_09015	COG3209	COG3209 Rhs family protein
HVX45_09035	COG5433	transposase activity
HVX45_09050	COG0615	ADP-L-glycero-beta-D-manno-heptose biosynthetic process
HVX45_09070	COG1536	FliG is one of three proteins (FliG, FliN, FliM) that forms the rotor-mounted switch complex (C ring), located at the base of the basal body. This complex interacts with the CheY and CheZ chemotaxis proteins, in addition to contacting components of the motor that determine the direction of flagellar rotation
HVX45_09080	COG1677	Flagellar hook-basal body complex protein FliE
HVX45_09105	COG1987	bacterial-type flagellum assembly
HVX45_09125	COG0507	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit has ssDNA-dependent ATPase and 5'-3' helicase activity. When added to pre-assembled RecBC greatly stimulates nuclease activity and augments holoenzyme processivity. Negatively regulates the RecA-loading ability of RecBCD
HVX45_09130	COG1074	ATP-dependent DNA helicase activity
HVX45_09135	COG1025	Belongs to the peptidase M16 family
HVX45_09140	COG1330	A helicase nuclease that prepares dsDNA breaks (DSB) for recombinational DNA repair. Binds to DSBs and unwinds DNA via a highly rapid and processive ATP-dependent bidirectional helicase activity. Unwinds dsDNA until it encounters a Chi (crossover hotspot instigator) sequence from the 3' direction. Cuts ssDNA a few nucleotides 3' to the Chi site. The properties and activities of the enzyme are changed at Chi. The Chi-altered holoenzyme produces a long 3'-ssDNA overhang and facilitates RecA-binding to the ssDNA for homologous DNA recombination and repair. Holoenzyme degrades any linearized DNA that is unable to undergo homologous recombination. In the holoenzyme this subunit recognizes the wild- type Chi sequence, and when added to isolated RecB increases its ATP-dependent helicase processivity
HVX45_09145	COG4967	type IV pilus modification protein PilV
HVX45_09155	COG4795	General secretion pathway protein
HVX45_09160	COG2165	general secretion pathway protein
HVX45_09190	COG0861	Integral membrane protein TerC family
HVX45_09200	COG0667	Aldo Keto reductase
HVX45_09225	COG1609	Transcriptional regulator
HVX45_09235	COG0583	DNA-binding transcription factor activity
HVX45_09240	COG0183	Belongs to the thiolase family
HVX45_09245	COG0814	amino acid
HVX45_09250	COG2771	luxR family
HVX45_09255	COG3710	Transcriptional regulator
HVX45_09265	COG1215	transferase activity, transferring glycosyl groups
HVX45_09270	COG4783	chaperone-mediated protein folding
HVX45_09280	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HVX45_09285	COG0402	S-adenosylhomocysteine deaminase activity
HVX45_09305	COG1388	LysM domain
HVX45_09305	COG1470	cell adhesion involved in biofilm formation
HVX45_09380	COG0582	viral genome integration into host DNA
HVX45_09390	COG4942	peptidase
HVX45_09395	COG0235	Class ii aldolase
HVX45_09410	COG1126	abc transporter atp-binding protein
HVX45_09415	COG0583	DNA-binding transcription factor activity
HVX45_09420	COG2072	flavoprotein involved in K transport
HVX45_09435	COG0624	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls
HVX45_09440	COG0076	glutamate decarboxylase activity
HVX45_09445	COG2066	Belongs to the glutaminase family
HVX45_09450	COG2080	2 iron, 2 sulfur cluster binding
HVX45_09455	COG1319	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM
HVX45_09460	COG1529	Aldehyde oxidase and xanthine dehydrogenase
HVX45_09465	COG1975	Xanthine and CO dehydrogenases maturation factor, XdhC CoxF family
HVX45_09480	COG1190	Belongs to the class-II aminoacyl-tRNA synthetase family
HVX45_09490	COG0608	single-stranded DNA 5'-3' exodeoxyribonuclease activity
HVX45_09495	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HVX45_09500	COG4974	Belongs to the 'phage' integrase family
HVX45_09505	COG0716	FMN binding
HVX45_09515	COG2938	An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH
HVX45_09525	COG1272	protein, Hemolysin III
HVX45_09535	COG2723	6-phospho-beta-galactosidase activity
HVX45_09565	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HVX45_09570	COG0654	COG0654 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases
HVX45_09575	COG0006	proline dipeptidase activity
HVX45_09595	COG0212	Belongs to the 5-formyltetrahydrofolate cyclo-ligase family
HVX45_09605	COG0111	D-isomer specific 2-hydroxyacid dehydrogenase
HVX45_09620	COG2968	Membrane
HVX45_09625	COG1279	arginine transmembrane transporter activity
HVX45_09630	COG0668	transmembrane transport
HVX45_09635	COG0191	fructose-bisphosphate aldolase activity
HVX45_09650	COG1072	(Pantothenic acid kinase))
HVX45_09660	COG1494	fructose-1,6-bisphosphatase
HVX45_09665	COG1063	alcohol dehydrogenase
HVX45_09670	COG2213	PTS system mannitol-specific
HVX45_09675	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HVX45_09680	COG0330	HflC and HflK could
HVX45_09685	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HVX45_09690	COG0501	Belongs to the peptidase M48B family
HVX45_09705	COG1166	arginine decarboxylase activity
HVX45_09730	COG2814	Major facilitator Superfamily
HVX45_09740	COG2356	endonuclease I
HVX45_09745	COG1385	rRNA (uridine-N3-)-methyltransferase activity
HVX45_09750	COG0189	ligase activity
HVX45_09765	COG2805	Type II/IV secretion system protein
HVX45_09770	COG0325	Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis
HVX45_09775	COG0762	integral membrane protein
HVX45_09785	COG0127	Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA RNA and avoiding chromosomal lesions
HVX45_09790	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HVX45_09795	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HVX45_09800	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
HVX45_09815	COG0252	asparaginase activity
HVX45_09825	COG3171	Protein conserved in bacteria
HVX45_09835	COG1194	a g-specific adenine glycosylase
HVX45_09850	COG2211	Major facilitator Superfamily
HVX45_09855	COG1982	Orn Lys Arg decarboxylase major
HVX45_09860	COG1811	Na channel or pump
HVX45_09885	COG1989	Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue
HVX45_09905	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HVX45_09910	COG1459	type II secretion system
HVX45_09915	COG2165	general secretion pathway protein
HVX45_09930	COG4795	General secretion pathway protein
HVX45_09945	COG3149	Involved in a type II secretion system (T2SS, formerly general secretion pathway, GSP) for the export of proteins
HVX45_09970	COG0754	glutathionylspermidine amidase activity
HVX45_09975	COG2207	Transcriptional regulator
HVX45_09980	COG0625	glutathione transferase activity
HVX45_09985	COG0298	carbon dioxide binding
HVX45_09995	COG1773	rubredoxin
HVX45_10000	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
HVX45_10005	COG0374	Belongs to the NiFe NiFeSe hydrogenase large subunit family
HVX45_10010	COG5557	Pfam Polysulphide reductase, NrfD
HVX45_10015	COG0437	4 iron, 4 sulfur cluster binding
HVX45_10020	COG1740	oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor
HVX45_10035	COG0667	Aldo Keto reductase
HVX45_10045	COG1028	Short-chain dehydrogenase reductase Sdr
HVX45_10050	COG0848	biopolymer transport protein
HVX45_10055	COG0811	peptide transport
HVX45_10060	COG0626	cystathionine gamma-synthase activity
HVX45_10065	COG0586	Pfam SNARE associated Golgi protein
HVX45_10070	COG2207	Transcriptional regulator
HVX45_10075	COG1979	alcohol dehydrogenase
HVX45_10080	COG0656	L-ascorbic acid biosynthetic process
HVX45_10085	COG0471	metal ion transport
HVX45_10090	COG4238	major outer membrane lipoprotein
HVX45_10095	COG1032	radical SAM domain protein
HVX45_10100	COG2186	Transcriptional regulator
HVX45_10105	COG0246	Mannitol dehydrogenase
HVX45_10110	COG1063	alcohol dehydrogenase
HVX45_10115	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
HVX45_10140	COG0204	Acyl-transferase
HVX45_10145	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HVX45_10150	COG3111	PFAM Bacterial OB fold (BOF) protein
HVX45_10155	COG0745	RESPONSE REGULATOR receiver
HVX45_10160	COG0642	Histidine kinase
HVX45_10165	COG2249	NAD(P)H dehydrogenase (quinone) activity
HVX45_10170	COG1359	(4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity
HVX45_10175	COG0187	DNA topoisomerase II activity
HVX45_10180	COG3150	esterase
HVX45_10185	COG1409	Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes
HVX45_10190	COG3151	Protein conserved in bacteria
HVX45_10195	COG0494	nUDIX hydrolase
HVX45_10200	COG1538	Outer membrane efflux protein
HVX45_10210	COG0754	glutathionylspermidine amidase activity
HVX45_10220	COG2761	dithiol-disulfide isomerase involved in polyketide biosynthesis
HVX45_10230	COG3384	dioxygenase
HVX45_10245	COG3539	Fimbrial protein
HVX45_10250	COG3188	usher protein
HVX45_10255	COG3121	Chaperone
HVX45_10260	COG3539	Fimbrial protein
HVX45_10280	COG1585	Membrane protein implicated in regulation of membrane protease activity
HVX45_10285	COG2268	Band 7 protein
HVX45_10315	COG3025	triphosphatase activity
HVX45_10320	COG4991	sh3 domain protein
HVX45_10335	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HVX45_10350	COG0828	Belongs to the bacterial ribosomal protein bS21 family
HVX45_10355	COG0358	DNA primase activity
HVX45_10360	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HVX45_10420	COG3118	belongs to the thioredoxin family
HVX45_10430	COG2375	cellular response to nickel ion
HVX45_10435	COG1695	Transcriptional regulator
HVX45_10440	COG0840	transmembrane signaling receptor activity
HVX45_10450	COG0477	Major facilitator Superfamily
HVX45_10455	COG3501	Rhs element vgr protein
HVX45_10460	COG2186	Transcriptional regulator
HVX45_10465	COG0246	Mannitol dehydrogenase
HVX45_10475	COG3065	identical protein binding
HVX45_10480	COG2197	response regulator
HVX45_10485	COG1285	pathogenesis
HVX45_10500	COG3247	response to pH
HVX45_10505	COG2771	luxR family
HVX45_10510	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HVX45_10515	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HVX45_10520	COG2207	Transcriptional regulator
HVX45_10535	COG1846	Transcriptional regulator
HVX45_10560	COG1028	Short-chain dehydrogenase reductase Sdr
HVX45_10565	COG4638	Rieske (2fe-2S)
HVX45_10570	COG0633	Ferredoxin
HVX45_10575	COG2271	Major facilitator Superfamily
HVX45_10595	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HVX45_10600	COG1775	2-hydroxyglutaryl-CoA dehydratase, D-component
HVX45_10605	COG1924	4 iron, 4 sulfur cluster binding
HVX45_10615	COG0446	pyridine nucleotide-disulphide oxidoreductase
HVX45_10615	COG1902	pentaerythritol trinitrate reductase activity
HVX45_10620	COG0840	transmembrane signaling receptor activity
HVX45_10630	COG4145	pantothenate transmembrane transporter activity
HVX45_10640	COG3653	N-Acyl-D-aspartate D-glutamate deacylase
HVX45_10650	COG1846	Transcriptional regulator
HVX45_10655	COG0179	Fumarylacetoacetate (FAA) hydrolase
HVX45_10660	COG1012	belongs to the aldehyde dehydrogenase family
HVX45_10665	COG3384	dioxygenase
HVX45_10675	COG3971	2-oxopent-4-enoate hydratase activity
HVX45_10695	COG2368	4-hydroxyphenylacetate
HVX45_10700	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HVX45_10705	COG1966	Carbon starvation protein
HVX45_10710	COG2879	small protein
HVX45_10715	COG0523	cobalamin synthesis protein
HVX45_10740	COG0732	type I restriction modification DNA specificity domain
HVX45_10755	COG5457	Domain of unknown function (DUF1127)
HVX45_10760	COG1167	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain MocR family and their eukaryotic orthologs
HVX45_10770	COG2814	Major facilitator Superfamily
HVX45_10775	COG2733	membrane
HVX45_10825	COG1064	alcohol dehydrogenase
HVX45_10830	COG0433	COG0433 Predicted ATPase
HVX45_10835	COG0701	Predicted permease
HVX45_10840	COG0702	epimerase
HVX45_10845	COG0693	protein deglycase activity
HVX45_10860	COG3153	acetyltransferase
HVX45_10865	COG3154	lipid carrier protein
HVX45_10870	COG0826	peptidase U32
HVX45_10875	COG0826	peptidase U32
HVX45_10880	COG2141	COG2141 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases
HVX45_10885	COG3034	peptidoglycan biosynthetic process
HVX45_10930	COG0511	ligase activity, forming carbon-carbon bonds
HVX45_10955	COG0814	amino acid
HVX45_10960	COG0513	Belongs to the DEAD box helicase family
HVX45_11000	COG0195	Participates in both transcription termination and antitermination
HVX45_11020	COG2194	sulfuric ester hydrolase activity
HVX45_11030	COG1314	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HVX45_11040	COG0294	Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives
HVX45_11045	COG0465	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins
HVX45_11055	COG1534	Rna-binding protein
HVX45_11060	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HVX45_11065	COG2027	D-alanyl-D-alanine carboxypeptidase
HVX45_11075	COG0697	spore germination
HVX45_11090	COG0142	geranyltranstransferase activity
HVX45_11095	COG3423	Transcriptional regulator
HVX45_11105	COG5007	Belongs to the BolA IbaG family
HVX45_11110	COG3113	response to antibiotic
HVX45_11115	COG2854	intermembrane phospholipid transfer
HVX45_11120	COG1463	ABC-type transport system involved in resistance to organic solvents, periplasmic component
HVX45_11125	COG0767	ABC-type transport system involved in resistance to organic solvents, permease component
HVX45_11130	COG1127	ABC transporter
HVX45_11135	COG0530	calcium, potassium:sodium antiporter activity
HVX45_11140	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HVX45_11140	COG0517	IMP dehydrogenase activity
HVX45_11145	COG1778	Involved in the biosynthesis of lipopolysaccharides (LPSs). Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate (KDO 8-P) to 3-deoxy-D-manno-octulosonate (KDO) and inorganic phosphate
HVX45_11150	COG3117	lipopolysaccharide transmembrane transporter activity
HVX45_11155	COG1934	Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. May form a bridge between the inner membrane and the outer membrane, via interactions with LptC and LptD, thereby facilitating LPS transfer across the periplasm
HVX45_11160	COG1137	ATPase activity
HVX45_11165	COG1508	bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding
HVX45_11170	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HVX45_11185	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HVX45_11190	COG0515	serine threonine protein kinase
HVX45_11200	COG3155	Displays glyoxalase activity, catalyzing the conversion of glyoxal to glycolate
HVX45_11205	COG5002	protein histidine kinase activity
HVX45_11205	COG2198	Histidine kinase
HVX45_11205	COG0784	Response regulator, receiver
HVX45_11210	COG1242	4 iron, 4 sulfur cluster binding
HVX45_11215	COG0069	glutamate synthase activity
HVX45_11215	COG0067	glutamate synthase
HVX45_11215	COG0070	glutamate synthase
HVX45_11220	COG0493	'glutamate synthase
HVX45_11225	COG4804	nuclease activity
HVX45_11230	COG2731	YhcH YjgK YiaL family protein
HVX45_11260	COG2969	positive regulation of protein catabolic process
HVX45_11265	COG0625	glutathione transferase activity
HVX45_11280	COG1485	Reduces the stability of FtsZ polymers in the presence of ATP
HVX45_11285	COG3105	Protein conserved in bacteria
HVX45_11290	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HVX45_11295	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HVX45_11305	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HVX45_11310	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
HVX45_11315	COG0471	metal ion transport
HVX45_11325	COG1802	Transcriptional regulator
HVX45_11345	COG2732	(Barnase) inhibitor
HVX45_11365	COG0583	DNA-binding transcription factor activity
HVX45_11370	COG0312	modulator of DNA gyrase
HVX45_11375	COG3164	Protein of unknown function
HVX45_11380	COG1530	ribonuclease E activity
HVX45_11390	COG2891	Involved in formation of the rod shape of the cell. May also contribute to regulation of formation of penicillin-binding proteins
HVX45_11395	COG1792	Involved in formation and maintenance of cell shape
HVX45_11400	COG1077	Cell shape determining protein MreB Mrl
HVX45_11405	COG2199	diguanylate cyclase activity
HVX45_11405	COG2200	EAL domain
HVX45_11410	COG0604	alcohol dehydrogenase
HVX45_11425	COG0511	ligase activity, forming carbon-carbon bonds
HVX45_11430	COG0439	Biotin carboxylase
HVX45_11435	COG3924	membrane
HVX45_11440	COG4145	pantothenate transmembrane transporter activity
HVX45_11450	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HVX45_11460	COG2189	Belongs to the N(4) N(6)-methyltransferase family
HVX45_11470	COG1309	transcriptional regulator
HVX45_11475	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HVX45_11480	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HVX45_11490	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HVX45_11495	COG4597	amino acid ABC transporter
HVX45_11500	COG0765	amino acid transport
HVX45_11505	COG1126	abc transporter atp-binding protein
HVX45_11545	COG0663	COG0663 Carbonic anhydrases acetyltransferases, isoleucine patch superfamily
HVX45_11565	COG0551	DNA topoisomerase type I activity
HVX45_11575	COG0758	DNA mediated transformation
HVX45_11595	COG0569	domain protein
HVX45_11605	COG3036	rescue of stalled ribosome
HVX45_11610	COG0789	Transcriptional regulator
HVX45_11650	COG0201	protein transport
HVX45_11740	COG0089	rRNA binding
HVX45_11755	COG0051	transcription antitermination factor activity, RNA binding
HVX45_11810	COG2964	Protein conserved in bacteria
HVX45_11815	COG0545	Peptidyl-prolyl cis-trans isomerase
HVX45_11825	COG1047	Peptidyl-prolyl cis-trans
HVX45_11830	COG3529	nucleic-acid-binding protein containing a Zn-ribbon domain
HVX45_11845	COG0488	(ABC) transporter
HVX45_11850	COG0429	hydrolase of the alpha beta-hydrolase fold
HVX45_11860	COG3954	Phosphoribulokinase
HVX45_11865	COG1765	OsmC-like protein
HVX45_11870	COG0664	- Catabolite gene activator and regulatory subunit of cAMP-dependent protein
HVX45_11875	COG1289	transmembrane transporter activity
HVX45_11880	COG4992	N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity
HVX45_11885	COG0512	Glutamine amidotransferase of anthranilate synthase
HVX45_11890	COG2184	nucleotidyltransferase activity
HVX45_11905	COG1251	Belongs to the nitrite and sulfite reductase 4Fe-4S domain family
HVX45_11910	COG2146	nitrite reductase [NAD(P)H] activity
HVX45_11915	COG2116	formate transmembrane transporter activity
HVX45_11930	COG0626	cystathionine gamma-synthase activity
HVX45_11945	COG1735	metal-dependent hydrolase with the TIM-barrel fold
HVX45_11950	COG1015	Phosphotransfer between the C1 and C5 carbon atoms of pentose
HVX45_11955	COG3457	Alanine racemase
HVX45_11965	COG2188	Transcriptional regulator
HVX45_11970	COG0180	Tryptophanyl-tRNA synthetase
HVX45_11980	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HVX45_11985	COG0338	D12 class N6 adenine-specific DNA methyltransferase
HVX45_11990	COG3266	domain, Protein
HVX45_12005	COG4796	Type ii and iii secretion system protein
HVX45_12020	COG3166	PFAM Fimbrial assembly family protein
HVX45_12025	COG4972	Pilus assembly protein
HVX45_12030	COG5009	serine-type D-Ala-D-Ala carboxypeptidase activity
HVX45_12035	COG0494	nUDIX hydrolase
HVX45_12045	COG1011	Hydrolase
HVX45_12050	COG1188	Ribosome-associated heat shock protein implicated in the recycling of the 50S subunit, (S4 paralog))
HVX45_12060	COG3449	Inhibits the supercoiling activity of DNA gyrase. Acts by inhibiting DNA gyrase at an early step, prior to (or at the step of) binding of DNA by the gyrase. It protects cells against toxins that target DNA gyrase, by inhibiting activity of these toxins and reducing the formation of lethal double-strand breaks in the cell
HVX45_12085	COG2205	protein histidine kinase activity
HVX45_12090	COG0745	RESPONSE REGULATOR receiver
HVX45_12095	COG0782	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
HVX45_12100	COG2183	response to ionizing radiation
HVX45_12105	COG1918	ferrous iron import across plasma membrane
HVX45_12110	COG0370	Transporter of a GTP-driven Fe(2 ) uptake system
HVX45_12120	COG5464	transposase or invertase
HVX45_12125	COG0596	Alpha beta hydrolase
HVX45_12140	COG2610	gluconate transmembrane transporter activity
HVX45_12150	COG1640	4-alpha-glucanotransferase
HVX45_12155	COG0058	SHG alpha-glucan phosphorylase activity
HVX45_12170	COG1690	Belongs to the RtcB family
HVX45_12175	COG4650	regulator
HVX45_12180	COG1349	DNA-binding transcription factor activity
HVX45_12195	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HVX45_12210	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HVX45_12220	COG3121	Chaperone
HVX45_12230	COG3539	Fimbrial protein
HVX45_12235	COG3188	usher protein
HVX45_12240	COG3121	Chaperone
HVX45_12250	COG0058	SHG alpha-glucan phosphorylase activity
HVX45_12275	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HVX45_12280	COG2095	MarC family integral membrane protein
HVX45_12285	COG2610	gluconate transmembrane transporter activity
HVX45_12290	COG3265	gluconokinase activity
HVX45_12295	COG1609	Transcriptional regulator
HVX45_12300	COG1741	Belongs to the pirin family
HVX45_12305	COG0673	inositol 2-dehydrogenase activity
HVX45_12310	COG1247	-acetyltransferase
HVX45_12315	COG0405	Gamma-glutamyltransferase
HVX45_12325	COG0584	glycerophosphoryl diester phosphodiesterase
HVX45_12340	COG1175	transmembrane transport
HVX45_12345	COG1653	transport
HVX45_12355	COG0410	ABC transporter
HVX45_12360	COG0411	ABC transporter
HVX45_12365	COG4177	L-phenylalanine transmembrane transporter activity
HVX45_12370	COG0559	Belongs to the binding-protein-dependent transport system permease family
HVX45_12375	COG0683	leucine binding
HVX45_12380	COG0456	acetyltransferase
HVX45_12385	COG0683	leucine binding
HVX45_12390	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HVX45_12395	COG2177	Part of the ABC transporter FtsEX involved in
HVX45_12400	COG2884	Cell division ATP-binding protein ftsE
HVX45_12405	COG0552	protein localization to endoplasmic reticulum
HVX45_12410	COG0742	ribosomal rna small subunit methyltransferase
HVX45_12415	COG3776	membrane
HVX45_12425	COG3714	YhhN family
HVX45_12440	COG1738	Involved in the import of queuosine (Q) precursors, required for Q precursor salvage
HVX45_12455	COG0628	permease
HVX45_12475	COG0204	Acyl-transferase
HVX45_12485	COG0236	Carrier of the growing fatty acid chain in fatty acid biosynthesis
HVX45_12505	COG1216	Glycosyl transferase, family 2
HVX45_12530	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HVX45_12540	COG1028	Short-chain dehydrogenase reductase Sdr
HVX45_12545	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HVX45_12550	COG2091	lysine biosynthetic process via aminoadipic acid
HVX45_12560	COG0842	Transport permease protein
HVX45_12565	COG0842	Transport permease protein
HVX45_12565	COG1129	ABC transporter
HVX45_12570	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HVX45_12580	COG5297	Belongs to the glycosyl hydrolase family 6
HVX45_12580	COG4733	cellulase activity
HVX45_12595	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HVX45_12600	COG2081	HI0933 family
HVX45_12605	COG0306	phosphate transporter
HVX45_12615	COG0589	response to stress
HVX45_12620	COG3104	oligopeptide transport
HVX45_12630	COG0339	signal peptide processing
HVX45_12635	COG2961	Specifically methylates the adenine in position 2030 of 23S rRNA
HVX45_12640	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HVX45_12650	COG0640	Transcriptional regulator
HVX45_12655	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HVX45_12660	COG1393	Belongs to the ArsC family
HVX45_12680	COG2197	response regulator
HVX45_12685	COG1295	ribonuclease BN
HVX45_12690	COG0477	Major facilitator Superfamily
HVX45_12695	COG2982	Protein involved in outer membrane biogenesis
HVX45_12700	COG2200	EAL domain
HVX45_12705	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HVX45_12740	COG0612	Peptidase, M16
HVX45_12750	COG2200	EAL domain
HVX45_12750	COG2199	diguanylate cyclase activity
HVX45_12755	COG3118	belongs to the thioredoxin family
HVX45_12755	COG0457	Tetratricopeptide repeat
HVX45_12760	COG3405	Belongs to the glycosyl hydrolase 8 (cellulase D) family
HVX45_12765	COG1215	transferase activity, transferring glycosyl groups
HVX45_12795	COG2194	sulfuric ester hydrolase activity
HVX45_12825	COG0814	amino acid
HVX45_12835	COG4608	Belongs to the ABC transporter superfamily
HVX45_12840	COG0444	Belongs to the ABC transporter superfamily
HVX45_12845	COG1173	ABC-type dipeptide oligopeptide nickel transport systems, permease components
HVX45_12850	COG0601	transmembrane transport
HVX45_12855	COG0747	negative chemotaxis
HVX45_12870	COG2194	sulfuric ester hydrolase activity
HVX45_12875	COG2223	nitrite transmembrane transporter activity
HVX45_12880	COG5571	outer membrane autotransporter
HVX45_12885	COG2818	Glycosylase
HVX45_12890	COG0456	acetyltransferase
HVX45_12895	COG0243	molybdopterin cofactor binding
HVX45_12900	COG2885	chlorophyll binding
HVX45_12905	COG1609	Transcriptional regulator
HVX45_12915	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HVX45_12935	COG2814	Major facilitator Superfamily
HVX45_12940	COG2944	sequence-specific DNA binding
HVX45_12945	COG1278	Cold shock
HVX45_12980	COG3274	enterobacterial common antigen metabolic process
HVX45_12985	COG4682	membrane
HVX45_12990	COG1070	Carbohydrate kinase
HVX45_13000	COG1609	Transcriptional regulator
HVX45_13000	COG2207	Transcriptional regulator
HVX45_13005	COG2992	FlgJ-related protein
HVX45_13010	COG0366	Alpha amylase catalytic
HVX45_13015	COG3977	Valine--pyruvate aminotransferase
HVX45_13020	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HVX45_13025	COG1414	Transcriptional regulator
HVX45_13035	COG2731	YhcH YjgK YiaL family protein
HVX45_13040	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
HVX45_13045	COG1593	TRAP-type C4-dicarboxylate transport system, large permease component
HVX45_13050	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HVX45_13055	COG1070	Carbohydrate kinase
HVX45_13060	COG0269	3-dehydro-L-gulonate-6-phosphate decarboxylase activity
HVX45_13065	COG3623	hexulose-6-phosphate isomerase
HVX45_13070	COG0235	Class ii aldolase
HVX45_13075	COG1012	belongs to the aldehyde dehydrogenase family
HVX45_13080	COG1454	alcohol dehydrogenase
HVX45_13085	COG3276	selenocysteine insertion sequence binding
HVX45_13095	COG0625	glutathione transferase activity
HVX45_13100	COG1566	PFAM secretion protein HlyD family protein
HVX45_13110	COG4668	phosphoenolpyruvate-dependent sugar phosphotransferase system
HVX45_13110	COG2213	PTS system mannitol-specific
HVX45_13120	COG3722	fumarate hydratase activity
HVX45_13140	COG5295	Hep Hag repeat protein
HVX45_13150	COG2186	Transcriptional regulator
HVX45_13160	COG0219	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide
HVX45_13165	COG1045	serine acetyltransferase
HVX45_13180	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HVX45_13185	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HVX45_13195	COG4942	peptidase
HVX45_13200	COG2861	carbohydrate metabolic process
HVX45_13205	COG1216	Glycosyl transferase, family 2
HVX45_13210	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HVX45_13215	COG3078	GTPase activator activity
HVX45_13230	COG0749	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HVX45_13230	COG0258	In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity
HVX45_13235	COG0204	Acyl-transferase
HVX45_13240	COG5339	Protein conserved in bacteria
HVX45_13245	COG1651	Required for disulfide bond formation in some periplasmic proteins. Acts by transferring its disulfide bond to other proteins and is reduced in the process
HVX45_13250	COG2334	A protein kinase that phosphorylates Ser and Thr residues. Probably acts to suppress the effects of stress linked to accumulation of reactive oxygen species. Probably involved in the extracytoplasmic stress response
HVX45_13255	COG3084	Protein conserved in bacteria
HVX45_13260	COG0746	molybdenum cofactor guanylyltransferase activity
HVX45_13265	COG1763	Mo-molybdopterin cofactor biosynthetic process
HVX45_13295	COG4635	menaquinone-dependent protoporphyrinogen oxidase activity
HVX45_13300	COG0168	Low-affinity potassium transport system. Interacts with trk system potassium uptake protein TrkA
HVX45_13305	COG1739	Uncharacterized protein family UPF0029
HVX45_13330	COG0543	2 iron, 2 sulfur cluster binding
HVX45_13335	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HVX45_13340	COG0250	Participates in transcription elongation, termination and antitermination
HVX45_13350	COG0805	protein transport
HVX45_13355	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HVX45_13360	COG1826	Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes
HVX45_13370	COG3165	ubiquinone biosynthetic process from chorismate
HVX45_13380	COG1322	Protein conserved in bacteria
HVX45_13385	COG1414	Transcriptional regulator
HVX45_13390	COG3734	2-keto-3-deoxy-galactonokinase
HVX45_13395	COG0800	Aldolase
HVX45_13415	COG2820	Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1- phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis
HVX45_13420	COG0412	Dienelactone hydrolase
HVX45_13425	COG1335	isochorismatase
HVX45_13435	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HVX45_13440	COG1304	FMN binding
HVX45_13445	COG0549	Belongs to the carbamate kinase family
HVX45_13455	COG1457	Belongs to the purine-cytosine permease (2.A.39) family
HVX45_13460	COG0583	DNA-binding transcription factor activity
HVX45_13470	COG0620	Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation
HVX45_13475	COG0583	DNA-binding transcription factor activity
HVX45_13480	COG0697	spore germination
HVX45_13485	COG0561	phosphatase activity
HVX45_13490	COG2267	carboxylic ester hydrolase activity
HVX45_13495	COG1280	lysine exporter protein (LysE YggA)
HVX45_13500	COG1280	lysine exporter protein (LysE YggA)
HVX45_13505	COG0514	ATP-dependent DNA helicase (RecQ)
HVX45_13515	COG2829	1-acyl-2-lysophosphatidylserine acylhydrolase activity
HVX45_13520	COG2050	protein possibly involved in aromatic compounds catabolism
HVX45_13525	COG2962	Rard protein
HVX45_13535	COG0598	Magnesium transport protein CorA
HVX45_13540	COG1912	Pfam S-adenosyl-l-methionine hydroxide adenosyltransferase
HVX45_13545	COG0210	DNA helicase
HVX45_13550	COG1011	Hydrolase
HVX45_13560	COG3159	Protein conserved in bacteria
HVX45_13570	COG5567	small periplasmic lipoprotein
HVX45_13590	COG3072	Adenylate cyclase
HVX45_13605	COG2959	enzyme of heme biosynthesis
HVX45_13610	COG3071	HemY protein
HVX45_13620	COG3119	arylsulfatase activity
HVX45_13625	COG0641	radical SAM
HVX45_13650	COG1113	amino acid transport
HVX45_13670	COG2244	polysaccharide biosynthetic process
HVX45_13675	COG0399	UDP-4-amino-4-deoxy-L-arabinose aminotransferase
HVX45_13680	COG0456	acetyltransferase
HVX45_13685	COG1209	Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis
HVX45_13690	COG1088	dTDP-glucose 4,6-dehydratase activity
HVX45_13695	COG0677	UDP-N-acetyl-D-mannosamine dehydrogenase activity
HVX45_13700	COG0381	UDP-N-acetylglucosamine 2-epimerase activity
HVX45_13705	COG3765	Modulates the polysaccharide chain length of enterobacterial common antigen (ECA)
HVX45_13710	COG0472	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
HVX45_13715	COG1158	Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template
HVX45_13725	COG3118	belongs to the thioredoxin family
HVX45_13740	COG0210	DNA helicase
HVX45_13745	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HVX45_13755	COG0583	DNA-binding transcription factor activity
HVX45_13760	COG1171	Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short- lived. The second step is the nonenzymatic hydrolysis of the enamine imine intermediates to form 2-ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA
HVX45_13770	COG0115	Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family
HVX45_13775	COG3978	acetolactate synthase activity
HVX45_13795	COG0606	chelatase, subunit chli
HVX45_13800	COG3085	chromosome segregation
HVX45_13840	COG2186	Transcriptional regulator
HVX45_13845	COG1609	Transcriptional regulator
HVX45_13850	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HVX45_13855	COG1879	ABC-type sugar transport system periplasmic component
HVX45_13860	COG1172	Belongs to the binding-protein-dependent transport system permease family
HVX45_13865	COG1129	ABC transporter
HVX45_13895	COG1522	sequence-specific DNA binding
HVX45_13900	COG0716	FMN binding
HVX45_13915	COG3312	ion transport
HVX45_13975	COG0226	Part of the ABC transporter complex PstSACB involved in phosphate import
HVX45_13980	COG0573	inorganic phosphate transmembrane transporter activity
HVX45_13985	COG0581	inorganic phosphate transmembrane transporter activity
HVX45_13990	COG1117	ATPase-coupled phosphate ion transmembrane transporter activity
HVX45_13995	COG0704	Plays a role in the regulation of phosphate uptake
HVX45_14000	COG3711	transcriptional antiterminator
HVX45_14005	COG1263	PTS System
HVX45_14005	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HVX45_14005	COG2190	(PTS) system
HVX45_14010	COG2723	6-phospho-beta-galactosidase activity
HVX45_14020	COG2382	esterase
HVX45_14025	COG0363	glucosamine-6-phosphate deaminase activity
HVX45_14030	COG3196	Protein conserved in bacteria
HVX45_14040	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HVX45_14045	COG2252	PERMEase
HVX45_14055	COG0431	NADPH-dependent FMN reductase
HVX45_14060	COG2091	lysine biosynthetic process via aminoadipic acid
HVX45_14075	COG0814	amino acid
HVX45_14125	COG0592	DNA-directed DNA polymerase activity
HVX45_14135	COG0187	DNA topoisomerase II activity
HVX45_14140	COG3753	Protein conserved in bacteria
HVX45_14145	COG0561	phosphatase activity
HVX45_14155	COG2186	Transcriptional regulator
HVX45_14160	COG3734	2-keto-3-deoxy-galactonokinase
HVX45_14165	COG0800	Aldolase
HVX45_14175	COG2271	Major facilitator Superfamily
HVX45_14185	COG0823	Involved in the tonB-independent uptake of proteins
HVX45_14190	COG5645	(Lipo)protein
HVX45_14210	COG2188	Transcriptional regulator
HVX45_14225	COG2207	Transcriptional regulator
HVX45_14230	COG4146	Belongs to the sodium solute symporter (SSF) (TC 2.A.21) family
HVX45_14235	COG3119	arylsulfatase activity
HVX45_14245	COG2149	membrane
HVX45_14255	COG0641	radical SAM
HVX45_14260	COG2814	Major facilitator Superfamily
HVX45_14275	COG0028	Belongs to the TPP enzyme family
HVX45_14280	COG0440	acetolactate synthase activity
HVX45_14285	COG2197	response regulator
HVX45_14290	COG3851	Histidine kinase
HVX45_14295	COG2271	Major facilitator Superfamily
HVX45_14300	COG2271	Major facilitator Superfamily
HVX45_14320	COG1447	Phosphotransferase system cellobiose-specific component IIA
HVX45_14325	COG2723	6-phospho-beta-galactosidase activity
HVX45_14330	COG1455	protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity
HVX45_14340	COG1609	Transcriptional regulator
HVX45_14350	COG0697	spore germination
HVX45_14420	COG0582	viral genome integration into host DNA
HVX45_14430	COG2211	Major facilitator Superfamily
HVX45_14435	COG1501	Belongs to the glycosyl hydrolase 31 family
HVX45_14440	COG2982	Protein involved in outer membrane biogenesis
HVX45_14445	COG2233	PERMEase
HVX45_14450	COG0786	glutamate:sodium symporter activity
HVX45_14460	COG1200	Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA)
HVX45_14465	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HVX45_14470	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HVX45_14480	COG0194	GDP metabolic process
HVX45_14490	COG2860	membrane
HVX45_14495	COG1561	YicC-like family, N-terminal region
HVX45_14525	COG0452	Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine
HVX45_14555	COG1519	Transferase
HVX45_14560	COG0859	PFAM glycosyl transferase family 9
HVX45_14565	COG0438	transferase activity, transferring glycosyl groups
HVX45_14570	COG0515	serine threonine protein kinase
HVX45_14575	COG0438	transferase activity, transferring glycosyl groups
HVX45_14575	COG4641	Protein conserved in bacteria
HVX45_14580	COG0438	transferase activity, transferring glycosyl groups
HVX45_14585	COG1442	glycosyl transferase family 8
HVX45_14590	COG1442	glycosyl transferase family 8
HVX45_14595	COG3642	lipopolysaccharide core region biosynthetic process
HVX45_14615	COG0859	PFAM glycosyl transferase family 9
HVX45_14620	COG0859	PFAM glycosyl transferase family 9
HVX45_14630	COG0156	8-amino-7-oxononanoate synthase activity
HVX45_14645	COG2204	response regulator
HVX45_14650	COG3852	Histidine kinase
HVX45_14655	COG0174	glutamine synthetase
HVX45_14665	COG0561	phosphatase activity
HVX45_14675	COG0635	Involved in the biosynthesis of porphyrin-containing compound
HVX45_14695	COG1011	Hydrolase
HVX45_14710	COG0456	acetyltransferase
HVX45_14715	COG3905	.,Oxidizes proline to glutamate for use as a carbon and nitrogen source
HVX45_14725	COG2864	formate dehydrogenase
HVX45_14730	COG0437	4 iron, 4 sulfur cluster binding
HVX45_14745	COG0326	Molecular chaperone. Has ATPase activity
HVX45_14760	COG3711	transcriptional antiterminator
HVX45_14760	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HVX45_14765	COG1363	Peptidase, m42
HVX45_14770	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HVX45_14770	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HVX45_14775	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HVX45_14785	COG1454	alcohol dehydrogenase
HVX45_14810	COG1917	Cupin 2, conserved barrel domain protein
HVX45_14810	COG4977	sequence-specific DNA binding
HVX45_14820	COG0605	Destroys radicals which are normally produced within the cells and which are toxic to biological systems
HVX45_14825	COG2258	MOSC domain
HVX45_14830	COG2205	protein histidine kinase activity
HVX45_14835	COG0745	RESPONSE REGULATOR receiver
HVX45_14840	COG3678	ATP-independent chaperone mediated protein folding
HVX45_14855	COG1613	Sulfate ABC transporter periplasmic sulfate-binding protein
HVX45_14875	COG3152	Membrane
HVX45_14880	COG3691	Protein conserved in bacteria
HVX45_14885	COG0589	response to stress
HVX45_14895	COG1494	fructose-1,6-bisphosphatase
HVX45_14905	COG0580	Belongs to the MIP aquaporin (TC 1.A.8) family
HVX45_14920	COG1575	Belongs to the MenA family. Type 1 subfamily
HVX45_14935	COG3087	Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides
HVX45_14940	COG1609	Transcriptional regulator
HVX45_14945	COG1198	Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA
HVX45_14960	COG3863	Permuted papain-like amidase enzyme, YaeF/YiiX, C92 family
HVX45_14970	COG0626	cystathionine gamma-synthase activity
HVX45_14975	COG0460	homoserine dehydrogenase
HVX45_14975	COG0527	aspartate kinase activity
HVX45_14985	COG0737	Belongs to the 5'-nucleotidase family
HVX45_14990	COG0685	methylenetetrahydrofolate reductase (NAD(P)H) activity
HVX45_15000	COG0697	spore germination
HVX45_15005	COG3738	Protein conserved in bacteria
HVX45_15010	COG0371	Dehydrogenase
HVX45_15015	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HVX45_15020	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HVX45_15020	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HVX45_15020	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HVX45_15025	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HVX45_15030	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HVX45_15035	COG1882	Formate acetyltransferase
HVX45_15040	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HVX45_15045	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HVX45_15050	COG2207	Transcriptional regulator
HVX45_15055	COG2194	sulfuric ester hydrolase activity
HVX45_15070	COG0002	Catalyzes the NADPH-dependent reduction of N-acetyl-5- glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde
HVX45_15085	COG0583	DNA-binding transcription factor activity
HVX45_15095	COG1473	amidohydrolase
HVX45_15100	COG0477	Major facilitator Superfamily
HVX45_15105	COG1309	transcriptional regulator
HVX45_15120	COG4206	TonB-dependent receptor
HVX45_15150	COG0812	UDP-N-acetylmuramate dehydrogenase activity
HVX45_15155	COG1654	Acts both as a biotin-- acetyl-CoA-carboxylase ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio- 5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon
HVX45_15155	COG0340	biotin-[acetyl-CoA-carboxylase] ligase activity
HVX45_15190	COG0690	P-P-bond-hydrolysis-driven protein transmembrane transporter activity
HVX45_15195	COG0250	Participates in transcription elongation, termination and antitermination
HVX45_15230	COG0502	Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical- based mechanism
HVX45_15240	COG2104	thiamine diphosphate biosynthetic process
HVX45_15245	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HVX45_15280	COG3068	Protein conserved in bacteria
HVX45_15295	COG3678	ATP-independent chaperone mediated protein folding
HVX45_15300	COG4191	Histidine kinase
HVX45_15305	COG2204	response regulator
HVX45_15310	COG0151	Belongs to the GarS family
HVX45_15340	COG0456	acetyltransferase
HVX45_15350	COG2225	Involved in the glycolate utilization. Catalyzes the condensation and subsequent hydrolysis of acetyl-coenzyme A (acetyl-CoA) and glyoxylate to form malate and CoA
HVX45_15355	COG2224	Isocitrate lyase
HVX45_15370	COG1414	Transcriptional regulator
HVX45_15375	COG1410	methionine synthase
HVX45_15375	COG0646	methionine synthase
HVX45_15390	COG1283	sodium-dependent phosphate transmembrane transporter activity
HVX45_15395	COG3122	Protein conserved in bacteria
HVX45_15435	COG1187	pseudouridine synthase activity
HVX45_15450	COG3541	Predicted nucleotidyltransferase
HVX45_15470	COG5301	cellulose 1,4-beta-cellobiosidase activity
HVX45_15550	COG0741	lytic transglycosylase activity
HVX45_15570	COG0527	aspartate kinase activity
HVX45_15595	COG4775	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HVX45_15610	COG3833	ABC-type maltose transport systems, permease component
HVX45_15615	COG1175	transmembrane transport
HVX45_15620	COG2182	Extracellular solute-binding protein
HVX45_15625	COG3842	ATPase activity
HVX45_15655	COG0818	Recycling of diacylglycerol produced during the turnover of membrane phospholipid
HVX45_15665	COG0534	Mate efflux family protein
HVX45_15670	COG3237	CsbD-like
HVX45_15675	COG0735	belongs to the Fur family
HVX45_15680	COG0042	Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines
HVX45_15690	COG0604	alcohol dehydrogenase
HVX45_15695	COG0305	Participates in initiation and elongation during chromosome replication
HVX45_15710	COG0787	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids
HVX45_15725	COG1448	Aminotransferase
HVX45_15730	COG0567	Dehydrogenase, E1 component
HVX45_15740	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HVX45_15745	COG0045	succinate-CoA ligase (ADP-forming) activity
HVX45_15750	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HVX45_15755	COG0471	metal ion transport
HVX45_15760	COG2055	Belongs to the LDH2 MDH2 oxidoreductase family
HVX45_15775	COG3700	Belongs to the class B bacterial acid phosphatase family
HVX45_15780	COG0432	Pfam Uncharacterised protein family UPF0047
HVX45_15785	COG2315	Protein conserved in bacteria
HVX45_15790	COG0178	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
HVX45_15795	COG0629	single-stranded DNA binding
HVX45_15810	COG0789	Transcriptional regulator
HVX45_15815	COG2252	PERMEase
HVX45_15820	COG0025	NhaP-type Na H and K H
HVX45_15825	COG2824	Alkylphosphonate utilization operon protein PhnA
HVX45_15830	COG0699	ATPase. Has a role at an early stage in the morphogenesis of the spore coat
HVX45_15845	COG0642	Histidine kinase
HVX45_15850	COG0745	RESPONSE REGULATOR receiver
HVX45_15855	COG2194	sulfuric ester hydrolase activity
HVX45_15860	COG2207	Transcriptional regulator
HVX45_15865	COG3647	Membrane
HVX45_15870	COG1838	Catalyzes the reversible hydration of fumarate to (S)- malate
HVX45_15870	COG1951	Catalyzes the reversible hydration of fumarate to (S)- malate
HVX45_15875	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HVX45_15880	COG4565	transcriptional regulatory protein
HVX45_15885	COG3290	protein histidine kinase activity
HVX45_15890	COG0243	molybdopterin cofactor binding
HVX45_15895	COG0437	4 iron, 4 sulfur cluster binding
HVX45_15900	COG3302	dmso reductase anchor subunit
HVX45_15905	COG3381	protein complex oligomerization
HVX45_15925	COG1309	transcriptional regulator
HVX45_15930	COG4232	protein-disulfide reductase activity
HVX45_15940	COG2704	Responsible for the transport of C4-dicarboxylates from the periplasm across the inner membrane
HVX45_15945	COG1027	Aspartate ammonia-lyase
HVX45_15950	COG3030	protein affecting phage T7 exclusion by the F plasmid
HVX45_15955	COG0531	amino acid
HVX45_15980	COG1509	lysine 2,3-aminomutase activity
HVX45_15990	COG5510	response to toxic substance
HVX45_15995	COG5510	response to toxic substance
HVX45_16000	COG2076	Multidrug Resistance protein
HVX45_16005	COG3040	lipid binding
HVX45_16010	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HVX45_16025	COG0479	Belongs to the succinate dehydrogenase fumarate reductase iron-sulfur protein family
HVX45_16030	COG1053	succinate dehydrogenase
HVX45_16050	COG1511	domain protein
HVX45_16050	COG3264	Mechanosensitive ion channel
HVX45_16070	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HVX45_16095	COG1600	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr)
HVX45_16100	COG0063	ADP-dependent NAD(P)H-hydrate dehydratase activity
HVX45_16100	COG0062	Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration
HVX45_16105	COG0802	atpase or kinase
HVX45_16110	COG0860	N-Acetylmuramoyl-L-alanine amidase
HVX45_16130	COG2262	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis
HVX45_16135	COG0330	HflC and HflK could
HVX45_16140	COG0330	HflC and HflK could
HVX45_16145	COG3242	Uncharacterized protein conserved in bacteria (DUF2065)
HVX45_16160	COG0557	exoribonuclease II activity
HVX45_16165	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HVX45_16170	COG3789	protein conserved in bacteria
HVX45_16175	COG1842	Phage shock protein A
HVX45_16185	COG3766	membrane
HVX45_16190	COG5463	Belongs to the UPF0441 family
HVX45_16195	COG0754	glutathionylspermidine amidase activity
HVX45_16200	COG1960	acyl-CoA dehydrogenase activity
HVX45_16210	COG3650	response to hydrogen peroxide
HVX45_16215	COG1073	alpha beta
HVX45_16230	COG3037	sugar-specific permease SgaT UlaA
HVX45_16235	COG3414	Phosphotransferase system galactitol-specific IIB component
HVX45_16275	COG0238	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit
HVX45_16285	COG1638	TRAP-type C4-dicarboxylate transport system periplasmic component
HVX45_16295	COG3090	Trap-type c4-dicarboxylate transport system, small permease component
HVX45_16300	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HVX45_16305	COG4670	ketone body catabolic process
HVX45_16310	COG1024	Enoyl-CoA hydratase
HVX45_16325	COG1309	transcriptional regulator
HVX45_16330	COG3061	Opacity-associated protein A
HVX45_16335	COG0545	Peptidyl-prolyl cis-trans isomerase
HVX45_16340	COG1113	amino acid transport
HVX45_16350	COG0697	spore germination
HVX45_16355	COG0702	epimerase
HVX45_16360	COG1733	regulation of RNA biosynthetic process
HVX45_16365	COG0737	Belongs to the 5'-nucleotidase family
HVX45_16370	COG1218	3'(2'),5'-bisphosphate nucleotidase
HVX45_16375	COG3054	Bacterial protein of unknown function (YtfJ_HI0045)
HVX45_16385	COG1253	flavin adenine dinucleotide binding
HVX45_16390	COG2764	glyoxalase bleomycin resistance protein dioxygenase
HVX45_16400	COG0698	ribose 5-phosphate isomerase
HVX45_16405	COG1737	Transcriptional regulator
HVX45_16410	COG1879	ABC-type sugar transport system periplasmic component
HVX45_16415	COG1129	ABC transporter
HVX45_16420	COG1172	Belongs to the binding-protein-dependent transport system permease family
HVX45_16425	COG0036	Belongs to the ribulose-phosphate 3-epimerase family
HVX45_16430	COG1940	carbohydrate kinase activity
HVX45_16435	COG2015	COG2015, Alkyl sulfatase and related hydrolases
HVX45_16445	COG1566	PFAM secretion protein HlyD family protein
HVX45_16450	COG1289	transmembrane transporter activity
HVX45_16465	COG0790	COG0790 FOG TPR repeat, SEL1 subfamily
HVX45_16470	COG1301	dicarboxylic acid transport
HVX45_16475	COG4235	cytochrome complex assembly
HVX45_16480	COG3088	subunit of a heme lyase
HVX45_16485	COG1138	Cytochrome C-type biogenesis protein
HVX45_16490	COG3301	Polysulphide reductase, NrfD
HVX45_16495	COG0437	4 iron, 4 sulfur cluster binding
HVX45_16500	COG3303	Catalyzes the reduction of nitrite to ammonia, consuming six electrons in the process
HVX45_16510	COG0365	Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA
HVX45_16515	COG3162	membrane
HVX45_16530	COG0729	surface antigen
HVX45_16535	COG2911	Protein conserved in bacteria
HVX45_16540	COG2105	PFAM AIG2 family protein
HVX45_16545	COG0221	Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions
HVX45_16550	COG1879	ABC-type sugar transport system periplasmic component
HVX45_16555	COG1129	ABC transporter
HVX45_16560	COG1172	Belongs to the binding-protein-dependent transport system permease family
HVX45_16565	COG1172	Belongs to the binding-protein-dependent transport system permease family
HVX45_16575	COG0773	UDP-N-acetylmuramate-L-alanine ligase activity
HVX45_16585	COG0312	modulator of DNA gyrase
HVX45_16590	COG3783	Cytochrome b(562)
HVX45_16595	COG3077	Addiction module antitoxin, RelB DinJ family
HVX45_16600	COG2026	Addiction module toxin, RelE StbE family
HVX45_16605	COG0602	queuosine metabolic process
HVX45_16610	COG1328	CTP reductase activity
HVX45_16615	COG0366	Alpha amylase catalytic
HVX45_16620	COG1263	PTS System
HVX45_16620	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HVX45_16625	COG1609	Transcriptional regulator
HVX45_16635	COG0251	oxidation-reduction process
HVX45_16655	COG1438	arginine binding
HVX45_16660	COG1288	antiporter activity
HVX45_16665	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HVX45_16670	COG0549	Belongs to the carbamate kinase family
HVX45_16680	COG2731	YhcH YjgK YiaL family protein
HVX45_16685	COG0078	Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline
HVX45_16690	COG3076	Globally modulates RNA abundance by binding to RNase E (Rne) and regulating its endonucleolytic activity. Can modulate Rne action in a substrate-dependent manner by altering the composition of the degradosome
HVX45_16695	COG0456	acetyltransferase
HVX45_16705	COG0525	valine-tRNA ligase activity
HVX45_16710	COG2927	DNA polymerase III (CHI subunit)
HVX45_16720	COG0795	lipopolysaccharide-transporting ATPase activity
HVX45_16725	COG0795	lipopolysaccharide-transporting ATPase activity
HVX45_16730	COG2823	Periplasmic or secreted lipoprotein
HVX45_16750	COG0313	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA
HVX45_16760	COG1063	alcohol dehydrogenase
HVX45_16765	COG3775	system Galactitol-specific IIC component
HVX45_16770	COG3414	Phosphotransferase system galactitol-specific IIB component
HVX45_16775	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HVX45_16790	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HVX45_16790	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HVX45_16790	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HVX45_16795	COG1105	Belongs to the carbohydrate kinase PfkB family
HVX45_16805	COG1349	DNA-binding transcription factor activity
HVX45_16810	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HVX45_16815	COG2721	sulfolactate sulfo-lyase activity
HVX45_16825	COG2084	Dehydrogenase
HVX45_16835	COG1741	Belongs to the pirin family
HVX45_16840	COG0583	DNA-binding transcription factor activity
HVX45_16845	COG3152	Membrane
HVX45_16850	COG0435	Glutathione S-transferase
HVX45_16855	COG2259	Doxx family
HVX45_16865	COG5393	Putative Actinobacterial Holin-X, holin superfamily III
HVX45_16870	COG4575	ribosome binding
HVX45_16875	COG1422	Protein of unknown function (DUF1090)
HVX45_16885	COG0586	Pfam SNARE associated Golgi protein
HVX45_16890	COG2186	Transcriptional regulator
HVX45_16895	COG2271	Major facilitator Superfamily
HVX45_16905	COG2721	sulfolactate sulfo-lyase activity
HVX45_16915	COG3633	Involved in the import of serine and threonine into the cell, with the concomitant import of sodium (symport system)
HVX45_16920	COG0861	Integral membrane protein TerC family
HVX45_16925	COG0673	inositol 2-dehydrogenase activity
HVX45_16930	COG2949	membrane
HVX45_16935	COG1451	nucleotide metabolic process
HVX45_16960	COG1484	DNA-dependent DNA replication
HVX45_16975	COG2966	Psort location CytoplasmicMembrane, score
HVX45_16985	COG1917	Cupin 2, conserved barrel domain protein
HVX45_16985	COG2169	Transcriptional regulator
HVX45_16990	COG2197	response regulator
HVX45_16995	COG2197	response regulator
HVX45_17000	COG4114	ferric iron reductase
HVX45_17030	COG3050	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is
HVX45_17035	COG0456	acetyltransferase
HVX45_17040	COG1011	Hydrolase
HVX45_17050	COG2823	Periplasmic or secreted lipoprotein
HVX45_17060	COG4667	esterase of the alpha-beta hydrolase superfamily
HVX45_17065	COG0084	hydrolase, TatD family'
HVX45_17070	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HVX45_17075	COG1328	CTP reductase activity
HVX45_17110	COG3726	membrane protein affecting hemolysin expression
HVX45_17115	COG0560	Phosphoserine phosphatase
HVX45_17120	COG1066	DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function
HVX45_17125	COG1056	cytidyltransferase-related domain
HVX45_17125	COG3172	ATPase kinase involved in NAD metabolism
HVX45_17130	COG4737	Cytotoxic translational repressor of toxin-antitoxin stability system
HVX45_17140	COG0488	(ABC) transporter
HVX45_17145	COG0741	lytic transglycosylase activity
HVX45_17165	COG2207	Transcriptional regulator
HVX45_17165	COG3708	Transcriptional regulator
HVX45_17170	COG3045	CreA protein
HVX45_17175	COG0745	RESPONSE REGULATOR receiver
HVX45_17180	COG2205	protein histidine kinase activity
HVX45_17185	COG4452	Inner membrane protein CreD
HVX45_17190	COG0745	RESPONSE REGULATOR receiver
HVX45_17200	COG0565	Catalyzes the formation of 2'O-methylated cytidine (Cm32) or 2'O-methylated uridine (Um32) at position 32 in tRNA
HVX45_17210	COG0527	aspartate kinase activity
HVX45_17210	COG0460	homoserine dehydrogenase
HVX45_17220	COG0498	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine
HVX45_17235	COG1115	amino acid carrier protein
HVX45_17245	COG0521	Mo-molybdopterin cofactor biosynthetic process
HVX45_17250	COG1584	GPR1 FUN34 yaaH family protein
HVX45_17275	COG0583	DNA-binding transcription factor activity
HVX45_17290	COG0196	riboflavin kinase activity
HVX45_17305	COG1047	Peptidyl-prolyl cis-trans
HVX45_17335	COG1883	Na -transporting methylmalonyl-CoA oxaloacetate decarboxylase, beta subunit
HVX45_17340	COG5016	pyruvate
HVX45_17340	COG0511	ligase activity, forming carbon-carbon bonds
HVX45_17395	COG0505	Belongs to the CarA family
HVX45_17400	COG0458	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
HVX45_17450	COG0644	oxidoreductase
HVX45_17455	COG2440	electron transfer flavoprotein-ubiquinone oxidoreductase
HVX45_17460	COG2271	Major facilitator Superfamily
HVX45_17475	COG0262	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis
HVX45_17510	COG0760	Chaperone involved in the correct folding and assembly of outer membrane proteins. Recognizes specific patterns of aromatic residues and the orientation of their side chains, which are found more frequently in integral outer membrane proteins. May act in both early periplasmic and late outer membrane-associated steps of protein maturation
HVX45_17520	COG1076	Co-chaperone involved in the maturation of iron-sulfur cluster-containing proteins. Seems to help targeting proteins to be folded toward HscA
HVX45_17525	COG0564	pseudouridine synthase activity
HVX45_17535	COG0417	DNA replication proofreading
HVX45_17555	COG0235	Class ii aldolase
HVX45_17575	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HVX45_17585	COG3181	Tripartite tricarboxylate transporter family receptor
HVX45_17600	COG0586	Pfam SNARE associated Golgi protein
HVX45_17610	COG1178	ABC-type Fe3 transport system permease component
HVX45_17615	COG4143	(ABC) transporter
HVX45_17630	COG2814	Major facilitator Superfamily
HVX45_17635	COG2271	Major facilitator Superfamily
HVX45_17640	COG0583	DNA-binding transcription factor activity
HVX45_17650	COG0738	Major facilitator superfamily
HVX45_17675	COG0473	3-isopropylmalate dehydrogenase activity
HVX45_17695	COG0028	Belongs to the TPP enzyme family
HVX45_17700	COG0440	acetolactate synthase activity
HVX45_17710	COG1609	Transcriptional regulator
HVX45_17725	COG3116	cell division
HVX45_17730	COG0768	penicillin binding
HVX45_17735	COG0769	Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan
HVX45_17740	COG0770	UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase activity
HVX45_17755	COG0772	Belongs to the SEDS family
HVX45_17770	COG1181	Belongs to the D-alanine--D-alanine ligase family
HVX45_17775	COG1589	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly
HVX45_17780	COG0849	cell division
HVX45_17785	COG0206	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity
HVX45_17805	COG0494	nUDIX hydrolase
HVX45_17820	COG0237	dephospho-CoA kinase activity
HVX45_17830	COG1459	type II secretion system
HVX45_17835	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HVX45_17840	COG4969	Belongs to the N-Me-Phe pilin family
HVX45_17845	COG0157	Belongs to the NadC ModD family
HVX45_17850	COG3023	N-Acetylmuramoyl-L-alanine amidase
HVX45_17855	COG3725	Membrane protein required for beta-lactamase induction
HVX45_17860	COG1113	amino acid transport
HVX45_17865	COG2186	Transcriptional regulator
HVX45_17870	COG2609	component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2)
HVX45_17875	COG0508	dehydrogenase complex catalyzes the overall conversion of
HVX45_17880	COG1249	Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family
HVX45_17885	COG3064	Membrane
HVX45_17890	COG1049	propionate catabolic process, 2-methylcitrate cycle
HVX45_17915	COG2132	Multicopper oxidase
HVX45_17920	COG4993	Dehydrogenase
HVX45_17925	COG0634	Belongs to the purine pyrimidine phosphoribosyltransferase family
HVX45_17930	COG0288	reversible hydration of carbon dioxide
HVX45_17935	COG1131	(ABC) transporter
HVX45_17940	COG0842	Transport permease protein
HVX45_17945	COG2893	phosphoenolpyruvate-dependent sugar phosphotransferase system
HVX45_17950	COG0726	polysaccharide deacetylase
HVX45_17960	COG5464	transposase or invertase
HVX45_17975	COG3539	Fimbrial protein
HVX45_17980	COG3539	Fimbrial protein
HVX45_17985	COG3539	Fimbrial protein
HVX45_17990	COG3539	Fimbrial protein
HVX45_17995	COG3188	usher protein
HVX45_18000	COG3121	Chaperone
HVX45_18005	COG3539	Fimbrial protein
HVX45_18010	COG0801	2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase
HVX45_18015	COG0617	tRNA 3'-terminal CCA addition
HVX45_18025	COG1734	Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters
HVX45_18035	COG1514	Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester
HVX45_18040	COG1643	Atp-dependent helicase
HVX45_18045	COG0744	Peptidoglycan polymerase that catalyzes glycan chain elongation from lipid-linked precursors
HVX45_18050	COG4774	siderophore transport
HVX45_18055	COG1120	ATPase activity
HVX45_18060	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HVX45_18065	COG0609	Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily
HVX45_18090	COG2860	membrane
HVX45_18095	COG0614	abc-type fe3 -hydroxamate transport system, periplasmic component
HVX45_18110	COG0265	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
HVX45_18115	COG3835	regulator
HVX45_18125	COG1408	metallophosphoesterase
HVX45_18140	COG0024	Methionine aminopeptidase
HVX45_18165	COG0743	1-deoxy-D-xylulose-5-phosphate reductoisomerase activity
HVX45_18170	COG0020	Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids
HVX45_18175	COG0575	Belongs to the CDS family
HVX45_18180	COG0750	zinc metalloprotease
HVX45_18190	COG2825	PFAM Outer membrane chaperone Skp (OmpH)
HVX45_18195	COG1044	Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell
HVX45_18220	COG0587	DNA-directed DNA polymerase activity
HVX45_18235	COG0346	lactoylglutathione lyase activity
HVX45_18245	COG4568	rho-dependent transcription termination
HVX45_18255	COG4681	YaeQ
HVX45_18260	COG1186	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA
HVX45_18265	COG3015	lipoprotein NlpE involved in copper resistance
HVX45_18270	COG0791	NLP P60 protein
HVX45_18280	COG1720	tRNA m6t6A37 methyltransferase activity
HVX45_18290	COG1464	Belongs to the NlpA lipoprotein family
HVX45_18295	COG2011	ABC-type metal ion transport system permease component
HVX45_18305	COG0241	D,D-heptose 1,7-bisphosphate phosphatase
HVX45_18340	COG0656	L-ascorbic acid biosynthetic process
HVX45_18345	COG0583	DNA-binding transcription factor activity
HVX45_18355	COG2226	methyltransferase
HVX45_18360	COG1388	LysM domain
HVX45_18360	COG0741	lytic transglycosylase activity
HVX45_18370	COG2226	methyltransferase
HVX45_18380	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HVX45_18390	COG0388	Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source
HVX45_18400	COG1960	acyl-CoA dehydrogenase activity
HVX45_18410	COG0121	glutamine amidotransferase
HVX45_18415	COG3034	peptidoglycan biosynthetic process
HVX45_18420	COG0791	NLP P60 protein
HVX45_18430	COG0860	N-Acetylmuramoyl-L-alanine amidase
HVX45_18450	COG2821	murein-degrading enzyme. may play a role in recycling of muropeptides during cell elongation and or cell division
HVX45_18455	COG1179	involved in molybdopterin and THIamine biosynthesis family 1
HVX45_18460	COG2166	iron-sulfur cluster assembly
HVX45_18465	COG0520	Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine
HVX45_18475	COG0583	DNA-binding transcription factor activity
HVX45_18480	COG2363	Small membrane protein
HVX45_18495	COG1760	l-serine dehydratase
HVX45_18500	COG0814	amino acid
HVX45_18505	COG1611	Belongs to the LOG family
HVX45_18520	COG3098	single-species biofilm formation
HVX45_18525	COG0564	pseudouridine synthase activity
HVX45_18530	COG0716	FMN binding
HVX45_18550	COG4948	Mandelate Racemase Muconate Lactonizing
HVX45_18555	COG4948	Mandelate Racemase Muconate Lactonizing
HVX45_18560	COG1929	Belongs to the glycerate kinase type-1 family
HVX45_18565	COG2205	protein histidine kinase activity
HVX45_18565	COG4999	Histidine kinase
HVX45_18565	COG3850	Histidine kinase
HVX45_18565	COG3437	response regulator, receiver
HVX45_18570	COG2265	Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family
HVX45_18575	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HVX45_18580	COG3956	TIGRFAM MazG family protein
HVX45_18595	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
HVX45_18605	COG1512	COG1512 Beta-propeller domains of methanol dehydrogenase type
HVX45_18615	COG0602	queuosine metabolic process
HVX45_18625	COG0720	synthase
HVX45_18650	COG1203	CRISPR-associated helicase, Cas3
HVX45_18665	COG1857	crispr-associated protein
HVX45_18680	COG1518	maintenance of DNA repeat elements
HVX45_18685	COG0847	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. The epsilon subunit contain the editing function and is a proofreading 3'-5' exonuclease
HVX45_18690	COG2234	aminopeptidase activity
HVX45_18745	COG1388	LysM domain
HVX45_18745	COG4942	peptidase
HVX45_18750	COG0568	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
HVX45_18760	COG0163	prenyltransferase activity
HVX45_18765	COG0043	3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity
HVX45_18775	COG0639	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP
HVX45_18810	COG1129	ABC transporter
HVX45_18815	COG1172	Belongs to the binding-protein-dependent transport system permease family
HVX45_18820	COG1879	ABC-type sugar transport system periplasmic component
HVX45_18825	COG1349	DNA-binding transcription factor activity
HVX45_18840	COG3604	Transcriptional regulator
HVX45_18845	COG0309	Hydrogenase expression formation protein (HypE)
HVX45_18850	COG0409	Hydrogenase expression formation protein
HVX45_18855	COG0298	carbon dioxide binding
HVX45_18860	COG0378	Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG
HVX45_18865	COG0375	protein maturation
HVX45_18875	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HVX45_18880	COG0651	ATP synthesis coupled electron transport
HVX45_18885	COG0650	Formate hydrogenlyase subunit 4
HVX45_18890	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
HVX45_18890	COG3261	NADH dehydrogenase
HVX45_18895	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HVX45_18900	COG3260	NADH ubiquinone oxidoreductase 20
HVX45_18910	COG0680	Initiates the rapid degradation of small, acid-soluble proteins during spore germination
HVX45_18920	COG4680	protein conserved in bacteria
HVX45_18925	COG5499	transcription regulator containing HTH domain
HVX45_18930	COG2723	6-phospho-beta-galactosidase activity
HVX45_18935	COG1263	PTS System
HVX45_18935	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HVX45_18940	COG1609	Transcriptional regulator
HVX45_18945	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HVX45_18950	COG0068	Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of NiFe -hydrogenases using carbamoylphosphate as a substrate. It functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide
HVX45_18970	COG0794	Belongs to the SIS family. GutQ KpsF subfamily
HVX45_18970	COG0517	IMP dehydrogenase activity
HVX45_18980	COG2951	lytic endotransglycosylase activity
HVX45_18990	COG1546	Belongs to the CinA family
HVX45_19010	COG1551	Could accelerate the degradation of some genes transcripts potentially through selective RNA binding
HVX45_19040	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HVX45_19045	COG1238	metal cluster binding
HVX45_19060	COG2814	Major facilitator Superfamily
HVX45_19065	COG1566	PFAM secretion protein HlyD family protein
HVX45_19070	COG1846	Transcriptional regulator
HVX45_19080	COG1296	Branched-chain amino acid permease (Azaleucine resistance)
HVX45_19085	COG2814	Major facilitator Superfamily
HVX45_19090	COG2113	Glycine betaine
HVX45_19095	COG4176	ABC-type proline glycine betaine transport system permease component
HVX45_19100	COG4175	Glycine betaine
HVX45_19105	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HVX45_19110	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HVX45_19120	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HVX45_19125	COG2128	Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity
HVX45_19135	COG4575	ribosome binding
HVX45_19155	COG0607	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS
HVX45_19160	COG0640	Transcriptional regulator
HVX45_19165	COG0401	homolog of Blt101
HVX45_19170	COG1652	LysM domain
HVX45_19175	COG1802	Transcriptional regulator
HVX45_19180	COG1113	amino acid transport
HVX45_19185	COG0160	Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family
HVX45_19190	COG1012	belongs to the aldehyde dehydrogenase family
HVX45_19195	COG0579	oxidoreductase
HVX45_19205	COG0583	DNA-binding transcription factor activity
HVX45_19215	COG0666	response to abiotic stimulus
HVX45_19225	COG0074	Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit
HVX45_19230	COG1304	FMN binding
HVX45_19235	COG0549	Belongs to the carbamate kinase family
HVX45_19240	COG0402	S-adenosylhomocysteine deaminase activity
HVX45_19245	COG2519	Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA
HVX45_19255	COG1064	alcohol dehydrogenase
HVX45_19260	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HVX45_19265	COG0698	ribose 5-phosphate isomerase
HVX45_19275	COG2376	Dihydroxyacetone kinase
HVX45_19280	COG0149	triose-phosphate isomerase activity
HVX45_19285	COG1082	Xylose isomerase domain protein TIM barrel
HVX45_19290	COG2084	Dehydrogenase
HVX45_19295	COG2390	Transcriptional regulator
HVX45_19300	COG0393	Putative heavy-metal-binding
HVX45_19315	COG0582	viral genome integration into host DNA
HVX45_19335	COG1896	Catalyzes the strictly specific dephosphorylation of 2'- deoxyribonucleoside 5'-monophosphates
HVX45_19370	COG1846	Transcriptional regulator
HVX45_19380	COG4725	Belongs to the MT-A70-like family
HVX45_19390	COG4570	Endonuclease that resolves Holliday junction intermediates made during homologous genetic recombination and DNA repair. Exhibits sequence and structure-selective cleavage of four-way DNA junctions, where it introduces symmetrical nicks in two strands of the same polarity at the 5' side of dinucleotides. Corrects the defects in genetic recombination and DNA repair associated with inactivation of ruvAB or ruvC
HVX45_19400	COG1403	HNH endonuclease
HVX45_19405	COG0484	heat shock protein binding
HVX45_19415	COG1278	Cold shock
HVX45_19420	COG1278	Cold shock
HVX45_19440	COG3772	lysozyme
HVX45_19450	COG1278	Cold shock
HVX45_19470	COG5562	phage envelope protein
HVX45_19575	COG5301	cellulose 1,4-beta-cellobiosidase activity
HVX45_19580	COG2110	phosphatase homologous to the C-terminal domain of histone macroH2A1
HVX45_19605	COG2867	negative regulation of translational initiation
HVX45_19615	COG2913	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HVX45_19620	COG0497	DNA recombination
HVX45_19635	COG4536	flavin adenine dinucleotide binding
HVX45_19640	COG4137	Cytochrome C assembly protein
HVX45_19645	COG0541	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY
HVX45_19675	COG0722	Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D- arabino-heptulosonate-7-phosphate (DAHP)
HVX45_19680	COG0287	Prephenate dehydrogenase
HVX45_19680	COG1605	Chorismate mutase
HVX45_19685	COG1605	Chorismate mutase
HVX45_19685	COG0077	Prephenate dehydratase
HVX45_19695	COG1544	Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase
HVX45_19700	COG4105	Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane
HVX45_19705	COG0564	pseudouridine synthase activity
HVX45_19715	COG0542	response to heat
HVX45_19740	COG0477	Major facilitator Superfamily
HVX45_19745	COG5544	Lipoprotein
HVX45_19750	COG1502	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol
HVX45_19755	COG1670	COG1670 acetyltransferases, including N-acetylases of ribosomal proteins
HVX45_19755	COG1042	CoA-binding domain protein
HVX45_19755	COG0045	succinate-CoA ligase (ADP-forming) activity
HVX45_19765	COG3118	belongs to the thioredoxin family
HVX45_19770	COG0566	Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family
HVX45_19795	COG0513	Belongs to the DEAD box helicase family
HVX45_19805	COG0029	Catalyzes the oxidation of L-aspartate to iminoaspartate
HVX45_19815	COG1595	DNA-templated transcription, initiation
HVX45_19820	COG3073	An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic proteases finish degrading the anti-sigma factor, liberating sigma-E
HVX45_19825	COG3026	antisigma factor binding
HVX45_19830	COG3086	response to oxidative stress
HVX45_19840	COG0681	Belongs to the peptidase S26 family
HVX45_19860	COG0854	Catalyzes the complicated ring closure reaction between the two acyclic compounds 1-deoxy-D-xylulose-5-phosphate (DXP) and 3-amino-2-oxopropyl phosphate (1-amino-acetone-3-phosphate or AAP) to form pyridoxine 5'-phosphate (PNP) and inorganic phosphate
HVX45_19875	COG1145	4fe-4S ferredoxin, iron-sulfur binding domain protein
HVX45_19880	COG1737	Transcriptional regulator
HVX45_19885	COG0560	Phosphoserine phosphatase
HVX45_19900	COG0046	Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL
HVX45_19900	COG0047	phosphoribosylformylglycinamidine synthase activity
HVX45_19905	COG2205	protein histidine kinase activity
HVX45_19910	COG3170	Tfp pilus assembly protein FimV
HVX45_19915	COG2204	response regulator
HVX45_19920	COG0347	Belongs to the P(II) protein family
HVX45_19940	COG0524	Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5- phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway
HVX45_19955	COG1226	(belongs to the monovalent cation proton antiporter 2 (CPA2) transporter (TC 2.A.37) family)
HVX45_19955	COG4651	solute:proton antiporter activity
HVX45_19960	COG2223	nitrite transmembrane transporter activity
HVX45_19965	COG0737	Belongs to the 5'-nucleotidase family
HVX45_19980	COG2606	Belongs to the prolyl-tRNA editing family. YbaK EbsC subfamily
HVX45_19985	COG3735	TraB family
HVX45_19990	COG3549	Plasmid maintenance system killer
HVX45_19995	COG3093	addiction module antidote protein HigA
HVX45_20000	COG2217	Heavy metal translocating P-type atpase
HVX45_20005	COG0531	amino acid
HVX45_20030	COG0789	Transcriptional regulator
HVX45_20035	COG1585	Membrane protein implicated in regulation of membrane protease activity
HVX45_20040	COG0330	HflC and HflK could
HVX45_20045	COG4619	ABC transporter
HVX45_20050	COG0390	transport system, permease component
HVX45_20055	COG3118	belongs to the thioredoxin family
HVX45_20060	COG0300	oxidoreductase activity
HVX45_20065	COG2755	lipolytic protein G-D-S-L family
HVX45_20070	COG4181	ATPase activity
HVX45_20075	COG3127	ABC-type transport system involved in lysophospholipase L1, biosynthesis, permease component
HVX45_20080	COG3157	Type VI secretion system effector, Hcp
HVX45_20100	COG0549	Belongs to the carbamate kinase family
HVX45_20105	COG0026	Catalyzes the ATP-dependent conversion of 5- aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5- carboxyaminoimidazole ribonucleotide (N5-CAIR)
HVX45_20110	COG0041	Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR)
HVX45_20125	COG0652	PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
HVX45_20135	COG1988	membrane-bound metal-dependent
HVX45_20140	COG2501	S4 domain
HVX45_20180	COG2246	polysaccharide biosynthetic process
HVX45_20185	COG1017	nitric oxide dioxygenase activity
HVX45_20185	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HVX45_20195	COG2259	Doxx family
HVX45_20200	COG2814	Major facilitator Superfamily
HVX45_20205	COG3711	transcriptional antiterminator
HVX45_20210	COG1073	alpha beta
HVX45_20215	COG0483	inositol monophosphate 1-phosphatase activity
HVX45_20235	COG0822	iron-sulfur transferase activity
HVX45_20255	COG0633	Ferredoxin
HVX45_20260	COG2975	iron-sulfur cluster assembly
HVX45_20275	COG2897	thiosulfate sulfurtransferase activity
HVX45_20280	COG2373	Large extracellular alpha-helical protein
HVX45_20285	COG4953	penicillin-binding protein 1C
HVX45_20315	COG2976	Protein conserved in bacteria
HVX45_20330	COG1645	bacterial-type flagellum-dependent swarming motility
HVX45_20355	COG0516	GMP reductase activity
HVX45_20355	COG0517	IMP dehydrogenase activity
HVX45_20375	COG3133	Outer membrane lipoprotein
HVX45_20385	COG2200	EAL domain
HVX45_20390	COG0248	Ppx GppA phosphatase
HVX45_20400	COG0299	Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate
HVX45_20415	COG2233	PERMEase
HVX45_20425	COG1393	Belongs to the ArsC family
HVX45_20430	COG4783	chaperone-mediated protein folding
HVX45_20435	COG0628	permease
HVX45_20440	COG3604	Transcriptional regulator
HVX45_20450	COG3260	NADH ubiquinone oxidoreductase 20
HVX45_20455	COG1143	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HVX45_20460	COG3261	NADH dehydrogenase
HVX45_20460	COG3262	NADH dehydrogenase (ubiquinone), 30 kDa subunit
HVX45_20465	COG0651	ATP synthesis coupled electron transport
HVX45_20470	COG4237	Hydrogenase 4 membrane
HVX45_20475	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HVX45_20480	COG0650	Formate hydrogenlyase subunit 4
HVX45_20485	COG0651	ATP synthesis coupled electron transport
HVX45_20490	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HVX45_20495	COG1225	Alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
HVX45_20500	COG2716	regulation of RNA biosynthetic process
HVX45_20510	COG3317	Gram-negative-bacterium-type cell outer membrane assembly
HVX45_20520	COG2321	neutral zinc metallopeptidase
HVX45_20530	COG0400	carboxylic ester hydrolase activity
HVX45_20545	COG1393	Belongs to the ArsC family
HVX45_20555	COG0841	Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family
HVX45_20560	COG3850	Histidine kinase
HVX45_20565	COG1142	4fe-4S ferredoxin, iron-sulfur binding domain protein
HVX45_20565	COG0493	'glutamate synthase
HVX45_20575	COG5342	invasion associated locus B
HVX45_20580	COG0021	Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate
HVX45_20585	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HVX45_20590	COG0280	phosphate acetyltransferase
HVX45_20590	COG0281	malic enzyme
HVX45_20610	COG0860	N-Acetylmuramoyl-L-alanine amidase
HVX45_20630	COG2837	iron assimilation
HVX45_20635	COG1680	COG1680 Beta-lactamase class C and other penicillin binding
HVX45_20640	COG1263	PTS System
HVX45_20640	COG1264	protein-N(PI)-phosphohistidine-sugar phosphotransferase activity
HVX45_20655	COG1028	Short-chain dehydrogenase reductase Sdr
HVX45_20660	COG4150	thiosulfate binding
HVX45_20665	COG0555	PFAM binding-protein-dependent transport systems inner membrane component
HVX45_20670	COG4208	sulfate ABC transporter
HVX45_20675	COG1118	Part of the ABC transporter complex CysAWTP involved in sulfate thiosulfate import. Responsible for energy coupling to the transport system
HVX45_20680	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HVX45_20685	COG4884	unkown
HVX45_20685	COG3831	ATPase activity
HVX45_20700	COG2190	(PTS) system
HVX45_20705	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HVX45_20710	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HVX45_20715	COG0031	Belongs to the cysteine synthase cystathionine beta- synthase family
HVX45_20725	COG3115	cell septum assembly
HVX45_20735	COG3530	Putative quorum-sensing-regulated virulence factor
HVX45_20740	COG0385	Bile acid
HVX45_20750	COG0005	The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta- (deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate
HVX45_20755	COG2211	Major facilitator Superfamily
HVX45_20765	COG0583	DNA-binding transcription factor activity
HVX45_20795	COG3415	Transposase
HVX45_20800	COG3415	Transposase
HVX45_20815	COG2200	EAL domain
HVX45_20815	COG2199	diguanylate cyclase activity
HVX45_20820	COG1972	Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family
HVX45_20845	COG1445	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HVX45_20850	COG1299	protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity
HVX45_20855	COG0006	proline dipeptidase activity
HVX45_20860	COG1363	Peptidase, m42
HVX45_20865	COG1925	phosphoenolpyruvate-dependent sugar phosphotransferase system
HVX45_20865	COG1762	phosphoenolpyruvate-dependent sugar phosphotransferase system
HVX45_20865	COG1080	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr)
HVX45_20870	COG2207	Transcriptional regulator
HVX45_20875	COG3279	Response regulator of the LytR AlgR family
HVX45_20880	COG3275	phosphorelay sensor kinase activity
HVX45_20885	COG0436	Aminotransferase
HVX45_20895	COG1560	Kdo2-lipid A biosynthetic process
HVX45_20915	COG0154	amidase activity
HVX45_20935	COG4638	Rieske (2fe-2S)
HVX45_20945	COG1028	Short-chain dehydrogenase reductase Sdr
HVX45_20955	COG1853	conserved protein domain typically associated with flavoprotein oxygenases, DIM6 NTAB family
HVX45_20970	COG2116	formate transmembrane transporter activity
HVX45_20980	COG2067	long-chain fatty acid transport protein
HVX45_20985	COG3691	Protein conserved in bacteria
HVX45_21000	COG2062	phosphohistidine phosphatase, SixA
HVX45_21005	COG3539	Fimbrial protein
HVX45_21010	COG3188	usher protein
HVX45_21015	COG3121	Chaperone
HVX45_21020	COG3539	Fimbrial protein
HVX45_21025	COG3539	Fimbrial protein
HVX45_21030	COG3539	Fimbrial protein
HVX45_21060	COG0730	response to heat
HVX45_21065	COG3101	peptidyl-lysine hydroxylation
HVX45_21080	COG0304	beta-ketoacyl-acyl-carrier-protein synthase II activity
HVX45_21100	COG0136	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate
HVX45_21110	COG0586	Pfam SNARE associated Golgi protein
HVX45_21120	COG0285	dihydrofolate synthase activity
HVX45_21125	COG3147	Non-essential cell division protein that could be required for efficient cell constriction
HVX45_21130	COG1286	toxin biosynthetic process
HVX45_21135	COG0034	Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine
HVX45_21140	COG0163	prenyltransferase activity
HVX45_21145	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HVX45_21150	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HVX45_21155	COG4215	(ABC) transporter
HVX45_21160	COG4160	amino acid transport
HVX45_21165	COG4598	ABC transporter
HVX45_21170	COG5464	transposase or invertase
HVX45_21175	COG1090	epimerase
HVX45_21180	COG1539	Catalyzes the conversion of 7,8-dihydroneopterin to 6- hydroxymethyl-7,8-dihydropterin
HVX45_21185	COG0625	glutathione transferase activity
HVX45_21190	COG0625	glutathione transferase activity
HVX45_21195	COG0622	Phosphoesterase
HVX45_21205	COG1609	Transcriptional regulator
HVX45_21225	COG3959	Transketolase, thiamine diphosphate binding domain
HVX45_21230	COG1154	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)
HVX45_21240	COG0282	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction
HVX45_21255	COG0637	HAD-superfamily hydrolase subfamily IA, variant 3
HVX45_21260	COG0490	domain, Protein
HVX45_21260	COG0471	metal ion transport
HVX45_21270	COG0436	Aminotransferase
HVX45_21275	COG0583	DNA-binding transcription factor activity
HVX45_21295	COG1905	PFAM NADH dehydrogenase (ubiquinone) 24 kDa subunit
HVX45_21300	COG1894	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain
HVX45_21305	COG1034	ATP synthesis coupled electron transport
HVX45_21320	COG0839	Belongs to the complex I subunit 6 family
HVX45_21330	COG1009	NADH ubiquinone oxidoreductase subunit 5 chain L Multisubunit Na H antiporter, MnhA subunit
HVX45_21335	COG1008	NDH-1 shuttles electrons from NAD(P)H, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient
HVX45_21360	COG2304	oxidoreductase activity
HVX45_21365	COG0784	Response regulator, receiver
HVX45_21365	COG0835	chemotaxis
HVX45_21375	COG2153	protein acetylation
HVX45_21380	COG4575	ribosome binding
HVX45_21385	COG1169	isochorismate synthase
HVX45_21400	COG0447	Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4- dihydroxy-2-naphthoyl-CoA (DHNA-CoA)
HVX45_21410	COG0318	PFAM AMP-dependent synthetase and ligase
HVX45_21485	COG5464	transposase or invertase
HVX45_21490	COG0247	lactate metabolic process
HVX45_21500	COG0578	Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family
HVX45_21505	COG2271	Major facilitator Superfamily
HVX45_21510	COG0584	glycerophosphoryl diester phosphodiesterase
HVX45_21515	COG3642	lipopolysaccharide core region biosynthetic process
HVX45_21520	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HVX45_21525	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HVX45_21530	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HVX45_21535	COG3468	outer membrane autotransporter barrel domain protein
HVX45_21545	COG0188	A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner
HVX45_21550	COG0183	Belongs to the thiolase family
HVX45_21555	COG2031	fatty acid transporter
HVX45_21560	COG2057	Acyl CoA acetate 3-ketoacid CoA transferase beta subunit
HVX45_21565	COG1788	Acyl CoA acetate 3-ketoacid CoA transferase, alpha subunit
HVX45_21570	COG2204	response regulator
HVX45_21575	COG3852	Histidine kinase
HVX45_21580	COG2205	protein histidine kinase activity
HVX45_21580	COG0784	Response regulator, receiver
HVX45_21585	COG2197	response regulator
HVX45_21590	COG0642	Histidine kinase
HVX45_21590	COG2198	Histidine kinase
HVX45_21595	COG3203	Forms passive diffusion pores that allow small molecular weight hydrophilic materials across the outer membrane
HVX45_21600	COG1477	protein flavinylation
HVX45_21605	COG2169	Transcriptional regulator
HVX45_21605	COG0350	Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction the enzyme is irreversibly inactivated
HVX45_21610	COG3145	DNA-N1-methyladenine dioxygenase activity
HVX45_21615	COG4615	Cyclic peptide transporter
HVX45_21625	COG1126	abc transporter atp-binding protein
HVX45_21630	COG0765	amino acid transport
HVX45_21635	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HVX45_21645	COG5006	permease, DMT superfamily
HVX45_21650	COG3637	Has lipid A 3-O-deacylase activity. Hydrolyzes the ester bond at the 3 position of lipid A, a bioactive component of lipopolysaccharide (LPS), thereby releasing the primary fatty acyl moiety
HVX45_21655	COG2194	sulfuric ester hydrolase activity
HVX45_21665	COG1321	iron dependent repressor
HVX45_21670	COG1055	Involved in arsenical resistance. Thought to form the channel of an arsenite pump
HVX45_21675	COG1376	ErfK ybiS ycfS ynhG family protein
HVX45_21680	COG0488	(ABC) transporter
HVX45_21685	COG0561	phosphatase activity
HVX45_21690	COG1882	Formate acetyltransferase
HVX45_21695	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HVX45_21700	COG0176	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway
HVX45_21705	COG0476	Involved in molybdopterin and thiamine biosynthesis, family 2
HVX45_21710	COG0303	'Molybdopterin
HVX45_21735	COG2200	EAL domain
HVX45_21740	COG2199	diguanylate cyclase activity
HVX45_21755	COG2133	pyrroloquinoline quinone binding
HVX45_21760	COG0625	glutathione transferase activity
HVX45_21765	COG1686	Belongs to the peptidase S11 family
HVX45_21770	COG1349	DNA-binding transcription factor activity
HVX45_21775	COG0671	phosphoesterase, PA-phosphatase related
HVX45_21780	COG2814	Major facilitator Superfamily
HVX45_21790	COG0561	phosphatase activity
HVX45_21795	COG0738	Major facilitator superfamily
HVX45_21800	COG3226	Transcriptional regulator
HVX45_21815	COG0778	Nitroreductase
HVX45_21830	COG0687	Required for the activity of the bacterial periplasmic transport system of putrescine
HVX45_21835	COG3842	ATPase activity
HVX45_21840	COG1176	ABC-type spermidine putrescine transport system, permease component I
HVX45_21845	COG1177	transmembrane transport
HVX45_21860	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HVX45_21865	COG4160	amino acid transport
HVX45_21870	COG4215	(ABC) transporter
HVX45_21875	COG0834	ABC-type amino acid transport signal transduction systems periplasmic component domain
HVX45_21880	COG1126	abc transporter atp-binding protein
HVX45_21895	COG3023	N-Acetylmuramoyl-L-alanine amidase
HVX45_21900	COG0451	ADP-glyceromanno-heptose 6-epimerase activity
HVX45_21905	COG0702	epimerase
HVX45_21910	COG2008	Catalyzes the cleavage of L-allo-threonine and L- threonine to glycine and acetaldehyde
HVX45_21915	COG0028	Belongs to the TPP enzyme family
HVX45_21925	COG1018	Is involved in NO detoxification in an aerobic process, termed nitric oxide dioxygenase (NOD) reaction that utilizes O(2) and NAD(P)H to convert NO to nitrate, which protects the bacterium from various noxious nitrogen compounds. Therefore, plays a central role in the inducible response to nitrosative stress
HVX45_21935	COG2431	L-lysine efflux transmembrane transporter activity
HVX45_21950	COG3593	DNA synthesis involved in DNA repair
HVX45_21955	COG2990	Protein conserved in bacteria
HVX45_21960	COG0845	Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family
HVX45_21970	COG1278	Cold shock
HVX45_21980	COG0542	response to heat
HVX45_22000	COG4987	ABC transporter, CydDC cysteine exporter (CydDC-E) family, permease ATP-binding protein CydC
HVX45_22005	COG4988	ABC transporter
HVX45_22010	COG0492	ferredoxin-NADP+ reductase activity
HVX45_22015	COG1522	sequence-specific DNA binding
HVX45_22020	COG1178	ABC-type Fe3 transport system permease component
HVX45_22020	COG1674	ftsk spoiiie
HVX45_22030	COG2256	atpase related to the helicase subunit of the holliday junction resolvase
HVX45_22040	COG1335	isochorismatase
HVX45_22050	COG0531	amino acid
HVX45_22060	COG1180	Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S- adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine
HVX45_22065	COG4974	Belongs to the 'phage' integrase family
HVX45_22165	COG1278	Cold shock
HVX45_22200	COG0695	Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins
HVX45_22340	COG5301	cellulose 1,4-beta-cellobiosidase activity
HVX45_22375	COG3941	tape measure
HVX45_22420	COG5492	domain, Protein
HVX45_22420	COG4932	domain protein
HVX45_22465	COG1475	DNA binding
HVX45_22470	COG1475	DNA binding
HVX45_22560	COG1974	Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair
HVX45_22600	COG0317	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance
HVX45_22645	COG0328	RNA-DNA hybrid ribonuclease activity
HVX45_22675	COG0237	dephospho-CoA kinase activity
HVX45_22690	COG0207	Catalyzes the reductive methylation of 2'-deoxyuridine- 5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis
HVX45_22700	COG0208	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HVX45_22705	COG0209	Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides
HVX45_22885	COG1475	DNA binding
HVX45_23090	COG2805	Type II/IV secretion system protein
HVX45_23150	COG0741	lytic transglycosylase activity
HVX45_23165	COG2804	Type II secretory pathway, ATPase PulE Tfp pilus assembly pathway, ATPase PilB
HVX45_23205	COG3436	PFAM IS66 Orf2 family protein
HVX45_23210	COG4372	Transposase