locus-tag	class	description
G4Z02_00010	ENOG4108SGK	Tetr family transcriptional regulator
G4Z02_00015	ENOG4105DW3	Response regulator receiver modulated metal dependent phosphohydrolase
G4Z02_00030	ENOG4105CKM	Branched-chain carboxylic acid kinase
G4Z02_00040	ENOG4105DJ1	Phosphoenolpyruvate Carboxylase
G4Z02_00055	ENOG4105CM2	brancheD-chain amino acid aminotransferase
G4Z02_00060	ENOG4105D82	Glutamate dehydrogenase
G4Z02_00065	ENOG4108JQ1	Dehydrogenase
G4Z02_00070	ENOG4107STF	Involved in phosphonate degradation (By similarity)
G4Z02_00110	ENOG4105CGH	5'-nucleotidase
G4Z02_00115	ENOG4108K8S	endonuclease I
G4Z02_00125	ENOG4105DBI	uridine monophosphokinase
G4Z02_00150	ENOG4105CGH	5'-nucleotidase
G4Z02_00160	ENOG4105CG3	alpha amylase, catalytic region
G4Z02_00165	ENOG4105DRS	transport system, permease
G4Z02_00185	ENOG4105DRW	binding-protein-dependent transport systems inner membrane Component
G4Z02_00190	ENOG4105DB9	Binding-protein-dependent transport systems inner membrane component
G4Z02_00210	ENOG4108IUM	Glycogen debranching enzyme
G4Z02_00230	ENOG4105CEJ	Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post- translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity)
G4Z02_00245	ENOG4108K8S	endonuclease I
G4Z02_00265	ENOG41082MP	copper ion binding protein
G4Z02_00275	ENOG4105FJH	Di-iron-containing protein involved in the repair of iron-sulfur clusters damaged by oxidative and nitrosative stress conditions (By similarity)
G4Z02_00280	ENOG4105IJJ	transcriptional regulator, crp fnr family
G4Z02_00305	ENOG4107QW8	radical SAM domain protein
G4Z02_00320	ENOG4105PGM	cation diffusion facilitator family transporter
G4Z02_00370	ENOG4108RVA	ribokinase
G4Z02_00390	ENOG4105BZU	Histidine kinase
G4Z02_00440	ENOG4108UH4	Binds specifically to the SsrA RNA (tmRNA) and is required for stable association of SsrA with ribosomes (By similarity)
G4Z02_00445	ENOG4105C40	3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs (By similarity)
G4Z02_00470	ENOG4105CJI	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate (By similarity)
G4Z02_00485	ENOG4105D5S	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine (By similarity)
G4Z02_00490	ENOG4108HRN	Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate (By similarity)
G4Z02_00495	ENOG4108R3D	Electron transport complex
G4Z02_00505	ENOG4105DGN	Electron transport complex
G4Z02_00520	ENOG4105D6A	Electron transport complex
G4Z02_00525	ENOG4107QTR	Required for nitrogen fixation. May be part of a membrane complex functioning as an intermediate in the electron transport to nitrogenase (By similarity)
G4Z02_00535	ENOG4105D3R	alkyl hydroperoxide reductase
G4Z02_00540	ENOG41081BK	membrane protein-like protein
G4Z02_00545	ENOG4108R3D	Electron transport complex
G4Z02_00550	ENOG4105DGN	Electron transport complex
G4Z02_00555	ENOG4105DZB	Electron transport complex
G4Z02_00560	ENOG4106I92	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity)
G4Z02_00565	ENOG4105D6A	Electron transport complex
G4Z02_00575	ENOG4105C4M	(Ubiquinol oxidase) subunit I
G4Z02_00595	ENOG4105CXW	Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity)
G4Z02_00600	ENOG4105CNB	Catalyzes the synthesis of ADP-glucose, a sugar donor used in elongation reactions on alpha-glucans (By similarity)
G4Z02_00610	ENOG410902V	Modulates RecA activity (By similarity)
G4Z02_00615	ENOG4105CN1	protease
G4Z02_00620	ENOG4107AYK	membrAne
G4Z02_00625	ENOG4105CG1	Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA (By similarity)
G4Z02_00645	ENOG4105DE5	Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity)
G4Z02_00655	ENOG4105CKM	Branched-chain carboxylic acid kinase
G4Z02_00695	ENOG4105C8T	Leucyl-tRNA synthetase
G4Z02_00705	ENOG4105N5T	Radical SAM Protein
G4Z02_00710	ENOG4105CPC	Aldo Keto reductase
G4Z02_00715	ENOG4108K6F	triphosphoribosyl-dephospho-CoA synthase
G4Z02_00720	ENOG4105DUA	(citrate (pro-3S)-lyase ligase
G4Z02_00725	ENOG4105CHY	citrate lyase, alpha
G4Z02_00735	ENOG4105XGS	Covalent carrier of the coenzyme of citrate lyase (By similarity)
G4Z02_00755	ENOG4107YT1	Glutamate mutase subunit sigma
G4Z02_00775	ENOG4108W5N	phosphatidylglycerophosphatase a
G4Z02_00780	ENOG4105CAE	Modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by (I) promoting its recognition by IF2 and (II) impairing its binding to EFTu-GTP (By similarity)
G4Z02_00785	ENOG4105C25	Primosomal protein n'
G4Z02_00790	ENOG41080WI	Part of the ABC transporter complex BtuCDF involved in vitamin B12 import. Responsible for energy coupling to the transport system (By similarity)
G4Z02_00795	ENOG4108X4Q	Hydrolase
G4Z02_00800	ENOG4105CN5	Metallo-Beta-Lactamase
G4Z02_00805	ENOG4107CHF	5,6-aminomutase beta subunit
G4Z02_00810	ENOG4105EQ5	D-Lysine 5,6-aminomutase alpha subunit
G4Z02_00825	ENOG4105FRY	Dehydrogenase
G4Z02_00830	ENOG4105DE9	3-keto-5-aminohexanoate cleavage enzyme
G4Z02_00835	ENOG4108UYI	beta-alanyl-CoA ammonia lyase
G4Z02_00845	ENOG4107QP7	CoA-transferase subunit A
G4Z02_00850	ENOG4108Z7G	MaoC domain protein dehydratase
G4Z02_00865	ENOG4105ENN	converts alpha-aldose to the beta-anomer. It is active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose (By similarity)
G4Z02_00870	ENOG4105CKN	UDP-glucose-hexose-1-phosphate uridylyltransferase
G4Z02_00875	ENOG4105CMR	udp-glucose 4-epimerase
G4Z02_00880	ENOG4105CRD	Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P) (By similarity)
G4Z02_00885	ENOG4105CQ4	Transcriptional regulator
G4Z02_00895	ENOG4105CII	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision (By similarity)
G4Z02_00925	ENOG4105KG7	Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Essential for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA (By similarity)
G4Z02_00930	ENOG4107EEM	One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex (By similarity)
G4Z02_00940	ENOG4105VZN	Nucleic-acid-binding protein implicated in transcription termination
G4Z02_00945	ENOG4105CHV	Transcription elongation factor NusA
G4Z02_00950	ENOG4105K7D	Required for maturation of 30S ribosomal subunits (By similarity)
G4Z02_00955	ENOG4108RWN	rrna methyltransferase
G4Z02_00965	ENOG4105D8I	Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS (By similarity)
G4Z02_00980	ENOG4105D98	threonine synthase
G4Z02_00985	ENOG4105D5I	Catalyzes the ATP-dependent phosphorylation of L- homoserine to L-homoserine phosphate (By similarity)
G4Z02_01015	ENOG4105C6Y	Udp-glucose 6-dehydrogenase
G4Z02_01035	ENOG4105VXP	Protein of unknown function DUF86
G4Z02_01050	ENOG4105WD1	Membrane
G4Z02_01065	ENOG4105C6T	cysteine synthase
G4Z02_01085	ENOG4105C20	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity)
G4Z02_01090	ENOG4108ZMX	Domain of unknown function (DU1801)
G4Z02_01095	ENOG4105M2E	Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell (By similarity)
G4Z02_01100	ENOG4105K7Z	Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity)
G4Z02_01105	ENOG4107Y2X	deaminase
G4Z02_01110	ENOG4105DBV	ornithine carbamoyltransferase
G4Z02_01115	ENOG4107S4Y	M20 DapE family protein YgeY
G4Z02_01120	ENOG4105C6T	cysteine synthase
G4Z02_01125	ENOG4108IYI	Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine (By similarity)
G4Z02_01130	ENOG4105CPN	adenine deaminase
G4Z02_01145	ENOG4105C7W	Xanthine dehydrogenase
G4Z02_01150	ENOG4107RY0	Catalyzes the conversion of dihydroorotate to orotate (By similarity)
G4Z02_01155	ENOG4107UUR	Chlorohydrolase aminohydrolase
G4Z02_01180	ENOG4105C7W	Xanthine dehydrogenase
G4Z02_01210	ENOG4105CP7	Triose-phosphate isomerase
G4Z02_01215	ENOG4105KRI	phosphocarrier protein (HPr
G4Z02_01220	ENOG4105BZA	Phosphoglycerate kinase
G4Z02_01240	ENOG4105BZU	Histidine kinase
G4Z02_01245	ENOG4105CV1	Transketolase (EC 2.2.1.1)
G4Z02_01275	ENOG4105EG2	ABC transporter, permease
G4Z02_01295	ENOG4105DRW	binding-protein-dependent transport systems inner membrane Component
G4Z02_01330	ENOG4105ETE	Transcriptional regulator (LacI family
G4Z02_01345	ENOG4105ETE	Transcriptional regulator (LacI family
G4Z02_01350	ENOG4105DIW	FeS assembly protein SUFB
G4Z02_01355	ENOG4108UNV	SUF system FeS assembly protein, NifU family
G4Z02_01365	ENOG4105JRK	feS assembly protein SufD
G4Z02_01370	ENOG4105C3K	feS assembly ATPase SufC
G4Z02_01395	ENOG4108KN0	Choline kinase
G4Z02_01400	ENOG4105Q2H	domain protein
G4Z02_01410	ENOG4105EQI	Metal Dependent Phosphohydrolase
G4Z02_01415	ENOG4108IUM	Glycogen debranching enzyme
G4Z02_01420	ENOG4105D4J	Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate
G4Z02_01425	ENOG4108ZK7	protein family UPF0029, Impact, N-terminal protein
G4Z02_01450	ENOG4105DGN	Electron transport complex
G4Z02_01460	ENOG41080WF	Electron transport complex, RnfABCDGE type, G subunit
G4Z02_01465	ENOG4105D6A	Electron transport complex
G4Z02_01505	ENOG4105EPR	degv family
G4Z02_01520	ENOG41067TZ	transcriptional regulator, MarR family
G4Z02_01525	ENOG4105EPR	degv family
G4Z02_01530	ENOG4105BZ8	glutamate synthase
G4Z02_01535	ENOG4105CDJ	oxidoreductase FAD NAD(P)-binding domain protein
G4Z02_01570	ENOG4105CRN	Aminoglycoside phosphotransferase
G4Z02_01615	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
G4Z02_01620	ENOG4105CQU	Part of the ABC transporter complex LolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone, LolA. Responsible for the formation of the LolA-lipoprotein complex in an ATP-dependent manner (By similarity)
G4Z02_01655	ENOG4105C7S	Dehydrogenase
G4Z02_01660	ENOG4105CPP	Dehydrogenase, E1 component
G4Z02_01665	ENOG4107RUY	(E1 component), alpha subunit
G4Z02_01675	ENOG410841Q	phosphoesterase PA-phosphatase related protein
G4Z02_01680	ENOG4107ZXI	Rhomboid family
G4Z02_01690	ENOG4105DG4	malate L-lactate dehydrogenase
G4Z02_01700	ENOG4105CI6	Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving
G4Z02_01705	ENOG4105CJV	Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase
G4Z02_01710	ENOG4105DG6	mannose-6-phosphate isomerase
G4Z02_01720	ENOG4105CMR	udp-glucose 4-epimerase
G4Z02_01725	ENOG4105CJT	Mannose-1-phosphate guanylyltransferase
G4Z02_01735	ENOG4105C30	Nad-dependent epimerase dehydratase
G4Z02_01740	ENOG4105C0K	Gdp-mannose 4,6-dehydratase
G4Z02_01750	ENOG4105CET	Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria (By similarity)
G4Z02_01770	ENOG4105D2T	synthase
G4Z02_01780	ENOG4105CAJ	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity)
G4Z02_01785	ENOG4105CF4	DegT DnrJ EryC1 StrS aminotransferase
G4Z02_01790	ENOG4108IAJ	Nad-dependent epimerase dehydratase
G4Z02_01800	ENOG4105K64	Glycosyl transferase, family 2
G4Z02_01825	ENOG4108RYC	glycosyltransferase
G4Z02_01835	ENOG4107YJ4	chain length determinant protein
G4Z02_01855	ENOG4107Y70	Heat shock protein
G4Z02_01895	ENOG4105BZU	Histidine kinase
G4Z02_01910	ENOG4108WBT	adenosyltransferase
G4Z02_01935	ENOG4105CJ1	ABC, transporter
G4Z02_01955	ENOG4105CQX	Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol (By similarity)
G4Z02_01970	ENOG4105DFF	Rod shape-determining protein mreb
G4Z02_01975	ENOG4105DFF	Rod shape-determining protein mreb
G4Z02_01980	ENOG4105DFF	Rod shape-determining protein mreb
G4Z02_01990	ENOG4108KN7	Removes 5-oxoproline from various penultimate amino acid residues except L-proline (By similarity)
G4Z02_02005	ENOG4105DB7	PHP domain protein
G4Z02_02010	ENOG4105C3P	Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln) (By similarity)
G4Z02_02015	ENOG4105D7V	transposase
G4Z02_02020	ENOG4108UH6	UPF0754 membrane protein
G4Z02_02025	ENOG4105BZU	Histidine kinase
G4Z02_02040	ENOG4105E09	nadh pyrophosphatase
G4Z02_02050	ENOG4108YZ4	nudix hydrolase
G4Z02_02055	ENOG4108UQV	Membrane
G4Z02_02070	ENOG4105CTQ	phosphohexokinase
G4Z02_02075	ENOG4105F22	Major Facilitator Superfamily
G4Z02_02095	ENOG4105DM4	PTS System
G4Z02_02110	ENOG4105CM3	Catalyzes the NADPH-dependent formation of L-aspartate- semialdehyde (L-ASA) by the reductive dephosphorylation of L- aspartyl-4-phosphate (By similarity)
G4Z02_02115	ENOG4105CH2	amidohydrolase
G4Z02_02120	ENOG4105CHM	Aminotransferase
G4Z02_02125	ENOG4105EMU	Dehydrogenase
G4Z02_02145	ENOG4105CUU	Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP) (By similarity)
G4Z02_02150	ENOG4105KW6	This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance (By similarity)
G4Z02_02155	ENOG4105C4H	Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA (By similarity)
G4Z02_02180	ENOG4105CEN	a g-specific adenine glycosylase
G4Z02_02185	ENOG4105DAA	L-lactate
G4Z02_02215	ENOG4105CDA	abc transporter atp-binding protein
G4Z02_02220	ENOG4105EAD	ABC transporter
G4Z02_02225	ENOG4106PMH	Extracellular solute-binding protein family 3
G4Z02_02240	ENOG4105CK4	Destroys radicals which are normally produced within the cells and which are toxic to biological systems (By similarity)
G4Z02_02250	ENOG4105D5T	phosphonate abc transporter
G4Z02_02255	ENOG4105S7S	phosphonate abc transporter
G4Z02_02260	ENOG4105S7S	phosphonate abc transporter
G4Z02_02270	ENOG4108TKW	Glyoxalase Bleomycin resistance protein (Dioxygenase
G4Z02_02275	ENOG4105KVH	Transcriptional regulator
G4Z02_02340	ENOG41082YX	Transcriptional regulator, arsr family
G4Z02_02380	ENOG4105D8W	glucose-6-phosphate 1-dehydrogenase
G4Z02_02385	ENOG4105DAP	Nicotinate phosphoribosyltransferase
G4Z02_02400	ENOG4107RBJ	symporter
G4Z02_02405	ENOG4105DWR	Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin (By similarity)
G4Z02_02410	ENOG4105CGK	Exodeoxyribonuclease III
G4Z02_02420	ENOG4105BZ8	glutamate synthase
G4Z02_02435	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
G4Z02_02445	ENOG41084X4	Acylphosphatase (EC 3.6.1.7)
G4Z02_02450	ENOG41063V1	Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid (By similarity)
G4Z02_02460	ENOG4105CSX	c4-dicarboxylate anaerobic carrier
G4Z02_02470	ENOG4105W4C	monovalent cation H antiporter subunit F
G4Z02_02485	ENOG4105HC0	Na H antiporter
G4Z02_02490	ENOG4105MKQ	Monovalent cation H antiporter subunit C
G4Z02_02495	ENOG4108JPZ	Monovalent cation H antiporter subunit D
G4Z02_02510	ENOG4108YXI	Secondary thiamine-phosphate synthase enzyme
G4Z02_02545	ENOG4105C3B	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity)
G4Z02_02555	ENOG4105VZ8	Transcriptional regulator
G4Z02_02585	ENOG4105CZN	Potassium uptake protein
G4Z02_02605	ENOG4105CKD	glutathione-regulated potassium-efflux system protein
G4Z02_02625	ENOG4105CPI	Metal Dependent Phosphohydrolase
G4Z02_02630	ENOG4105BZU	Histidine kinase
G4Z02_02640	ENOG4105BZU	Histidine kinase
G4Z02_02655	ENOG4107QJQ	Mate efflux family protein
G4Z02_02660	ENOG4108BDP	Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate (By similarity)
G4Z02_02705	ENOG4105DY9	regulatoR
G4Z02_02720	ENOG4105D6J	arsenicaL-resistance protein
G4Z02_02730	ENOG4105C9K	Endothelin-converting enzyme 1
G4Z02_02745	ENOG4105CV8	reductase
G4Z02_02750	ENOG4105BZU	Histidine kinase
G4Z02_02755	ENOG4105VXP	Protein of unknown function DUF86
G4Z02_02780	ENOG4108UXA	Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA (By similarity)
G4Z02_02790	ENOG4105RKW	reductase (By
G4Z02_02810	ENOG4105C32	Amino acid ABC transporter (Permease)
G4Z02_02815	ENOG4105CF8	branched-chain amino acid ABC transporter, permease
G4Z02_02820	ENOG4105C0Z	ABC transporter
G4Z02_02825	ENOG4108IV0	ABC, transporter
G4Z02_02830	ENOG4105CAQ	asparagine synthetase
G4Z02_02840	ENOG4105C13	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
G4Z02_02850	ENOG4107QXI	Catalyzes the folate-dependent formation of 5-methyl- uridine at position 54 (M-5-U54) in all tRNAs (By similarity)
G4Z02_02860	ENOG4107S9Q	Maltosyltransferase that uses maltose 1-phosphate (M1P) as the sugar donor to elongate linear or branched alpha-(1- 4)- glucans. Is involved in a branched alpha-glucan biosynthetic pathway from trehalose, together with TreS, Mak and GlgB (By similarity)
G4Z02_02865	ENOG4105ETE	Transcriptional regulator (LacI family
G4Z02_02875	ENOG4107Z3H	Transcriptional regulator, TetR family
G4Z02_02885	ENOG4105BZT	Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity)
G4Z02_02895	ENOG4108YXI	Secondary thiamine-phosphate synthase enzyme
G4Z02_02900	ENOG4105BZT	Catalyzes the formation of 5-methyl-uridine at position 1939 (m5U1939) in 23S rRNA (By similarity)
G4Z02_02920	ENOG4105C2Y	STE24 endopeptidase EC 3.4.24.84
G4Z02_02955	ENOG4105CCW	damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage (By similarity)
G4Z02_02980	ENOG4105K7K	Transcriptional regulator
G4Z02_02990	ENOG4105CTQ	phosphohexokinase
G4Z02_02995	ENOG4105C0B	DNA polymerase III (alpha subunit)
G4Z02_03005	ENOG4105C6H	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity)
G4Z02_03015	ENOG4105VAS	Could be involved in insertion of integral membrane proteins into the membrane (By similarity)
G4Z02_03020	ENOG4108YXY	alkyl hydroperoxide reductase Thiol specific antioxidant Mal allergen
G4Z02_03035	ENOG41066DG	(EAL) domain protein
G4Z02_03055	ENOG4105E0M	Sulfatase
G4Z02_03065	ENOG4107V8I	Glycosyl transferases group 1
G4Z02_03075	ENOG4107RB4	Cytidine monophosphate kinase
G4Z02_03085	ENOG4105CG0	The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine (By similarity)
G4Z02_03090	ENOG4108IQ6	Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine (By similarity)
G4Z02_03100	ENOG4105CEK	Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine (By similarity)
G4Z02_03105	ENOG4105CIH	Imidazole acetol-phosphate transaminase
G4Z02_03110	ENOG4105ECC	imidazole-glycerol-phosphate dehydratase
G4Z02_03115	ENOG4108UJE	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of IGP and AICAR (By similarity)
G4Z02_03130	ENOG4105K8F	Phosphoribosyl-amp cyclohydrolase
G4Z02_03140	ENOG4105EPR	degv family
G4Z02_03145	ENOG4105EPR	degv family
G4Z02_03150	ENOG4108UT2	hemolysin iii
G4Z02_03165	ENOG410902H	NADH dehydrogenase (Ubiquinone), 24 kDa subunit
G4Z02_03170	ENOG4107QIZ	NADH dehydrogenase
G4Z02_03175	ENOG4107QHI	-hydrogenase
G4Z02_03180	ENOG4107QW3	Sucrose phosphorylase
G4Z02_03185	ENOG4105ETE	Transcriptional regulator (LacI family
G4Z02_03200	ENOG4107URF	beta-phospho-glucomutase
G4Z02_03220	ENOG4105CI2	imidazolone-5-propionate hydrolase
G4Z02_03225	ENOG4105CCS	Glutamate formiminotransferase
G4Z02_03230	ENOG4105CGP	Urocanate hydratase
G4Z02_03235	ENOG4105C84	Histidine ammonia-lyase
G4Z02_03260	ENOG4105DR1	Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity)
G4Z02_03275	ENOG4105EMN	RNA polymerase sigma factor
G4Z02_03280	ENOG4107ZXU	DSBA oxidoreductase
G4Z02_03290	ENOG4105E8R	UPF0173 metal-dependent hydrolase
G4Z02_03330	ENOG4107TFB	basic membrane
G4Z02_03345	ENOG4105CJH	Alcohol dehydrogenase zinc-binding domain protein
G4Z02_03360	ENOG4105C68	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity)
G4Z02_03400	ENOG4105DZR	Type I site-specific deoxyribonuclease
G4Z02_03405	ENOG4107XZC	Restriction modification system DNA (Specificity
G4Z02_03410	ENOG4105CVR	type I restriction-modification system
G4Z02_03420	ENOG4108C33	Resolvase
G4Z02_03435	ENOG4105C13	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
G4Z02_03450	ENOG4105C59	p-type ATPase
G4Z02_03455	ENOG41082YX	Transcriptional regulator, arsr family
G4Z02_03465	ENOG4107SET	aldo keto reductase
G4Z02_03470	ENOG4108Z5K	methylglyoxal synthase
G4Z02_03495	ENOG4105K8R	UPF0145 protein
G4Z02_03530	ENOG4108NIW	Leucine export protein LeuE
G4Z02_03560	ENOG4105NBF	ammecr1 domain protein
G4Z02_03570	ENOG4105CT4	transporter
G4Z02_03610	ENOG41082V8	Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein (By similarity)
G4Z02_03615	ENOG4105CIE	May be required for sporulation (By similarity)
G4Z02_03620	ENOG4105C3M	thioredoxin reductase
G4Z02_03625	ENOG4105C3B	Transfers the N-acyl diglyceride group on what will become the N-terminal cysteine of membrane lipoproteins (By similarity)
G4Z02_03630	ENOG4105D1C	Catalyzes the ATP- as well as the pyrophosphate- dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P- Ser-HPr). The two antagonistic activities of HprK P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion (By similarity)
G4Z02_03640	ENOG4105C5U	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate (By similarity)
G4Z02_03645	ENOG4105C77	DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA (By similarity)
G4Z02_03650	ENOG4105C4R	Atp-dependent dna helicase
G4Z02_03655	ENOG41080UX	Methyltransferase
G4Z02_03660	ENOG4105VEQ	Cold shock protein
G4Z02_03690	ENOG4105CPM	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
G4Z02_03715	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
G4Z02_03720	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
G4Z02_03725	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
G4Z02_03730	ENOG4105D6C	Part of the ABC transporter complex MacAB involved in macrolide export. Transmembrane domains (TMD) form a pore in the inner membrane and the ATP-binding domain (NBD) is responsible for energy generation (By similarity)
G4Z02_03735	ENOG41072GX	Peptidase M22 Glycoprotease
G4Z02_03740	ENOG4105K8N	protein family UPF0079, ATPase
G4Z02_03745	ENOG4109050	May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG)
G4Z02_03750	ENOG4106CC8	Bacterial inner membrane protein
G4Z02_03755	ENOG4107QYV	phosphohexose isomerase
G4Z02_03765	ENOG41083MR	nifu domain-containing protein
G4Z02_03775	ENOG4108UH8	Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4- diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (By similarity)
G4Z02_03780	ENOG4105CE5	Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) (By similarity)
G4Z02_03795	ENOG4105C8B	TIGR00159 family
G4Z02_03805	ENOG4105C1N	GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis (By similarity)
G4Z02_03810	ENOG4105CEH	Catalyzes the synthesis of dihydrouridine a modified base found in the D-loop of most tRNAs (By similarity)
G4Z02_03815	ENOG4105F4C	Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress (By similarity)
G4Z02_03820	ENOG4105D7K	pfkb domain protein
G4Z02_03825	ENOG4105C5F	glutamine synthetase
G4Z02_03835	ENOG4105C65	Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF- independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity)
G4Z02_03850	ENOG4105C7N	Xanthine uracil vitamin C permease
G4Z02_03860	ENOG4105C83	adenylosuccinate lyase
G4Z02_03865	ENOG4105CN0	Catalyzes the oxidation of 5,10- methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10- formyltetrahydrofolate (By similarity)
G4Z02_03875	ENOG4105CTD	carboxy-peptidase
G4Z02_03900	ENOG4105CMY	5-enolpyruvylshikimate-3-phosphate synthase
G4Z02_03905	ENOG4105D49	3-dehydroquinate synthase
G4Z02_03910	ENOG4105D10	5-enolpyruvylshikimate-3-phosphate phospholyase
G4Z02_03915	ENOG4105EHE	chorismate mutase- prephenate dehydrogenase
G4Z02_03920	ENOG4105E2X	shikimate dehydrogenase
G4Z02_03925	ENOG4108Z38	Catalyzes a trans-dehydration via an enolate intermediate (By similarity)
G4Z02_03930	ENOG4108JPM	phospho-2-dehydro-3-deoxyheptonate aldolase
G4Z02_03935	ENOG4105C91	Plays an important role in the de novo pathway of purine nucleotide biosynthesis
G4Z02_03940	ENOG4108JA2	transcriptioN-repair coupling factor
G4Z02_03945	ENOG4108ZPD	The natural substrate for this enzyme may be peptidyl- tRNAs which drop off the ribosome during protein synthesis (By similarity)
G4Z02_03955	ENOG4105DHW	Required for the insertion and or proper folding and or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins
G4Z02_03960	ENOG4105M7T	RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme (By similarity)
G4Z02_03965	ENOG4105VG0	50S ribosomal protein l34
G4Z02_03970	ENOG4105CI4	it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box) 5'-TTATC CA A CA A-3'. DnaA binds to ATP and to acidic phospholipids (By similarity)
G4Z02_03975	ENOG4105CZ8	DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The beta chain is required for initiation of replication once it is clamped onto DNA, it slides freely (bidirectional and ATP- independent) along duplex DNA (By similarity)
G4Z02_03985	ENOG4105C3X	it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP (By similarity)
G4Z02_03990	ENOG4105C7D	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
G4Z02_03995	ENOG4105C24	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
G4Z02_04000	ENOG4105CGR	Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity)
G4Z02_04005	ENOG4105BZ6	Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity)
G4Z02_04020	ENOG4105K59	histidine triad (HIT) protein
G4Z02_04025	ENOG4107XGZ	Hydrolase
G4Z02_04030	ENOG4108IJ2	phosphate acetyltransferase
G4Z02_04035	ENOG4109050	May catalyze the ATP-dependent phosphorylation of lipids other than diacylglycerol (DAG)
G4Z02_04045	ENOG4105HVR	Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step (By similarity)
G4Z02_04055	ENOG4105CTR	Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol (By similarity)
G4Z02_04060	ENOG4105K4W	Could be involved in septation (By similarity)
G4Z02_04065	ENOG4105C5T	Phosphoribosyl pyrophosphate synthase
G4Z02_04075	ENOG4105C5S	asparaginyl-tRNA synthetase
G4Z02_04100	ENOG4105CB3	Required for the thiolation of cytidine in position 32 of tRNA, to form 2-thiocytidine (s(2)C32) (By similarity)
G4Z02_04115	ENOG4105C6E	dna polymerase iii
G4Z02_04120	ENOG410816I	Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection (By similarity)
G4Z02_04125	ENOG4105F3K	May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO (By similarity)
G4Z02_04145	ENOG4105EG2	ABC transporter, permease
G4Z02_04175	ENOG4105SFS	phosphoesterase RecJ domain protein
G4Z02_04185	ENOG4105DPZ	Two component transcriptional regulator (Winged helix family
G4Z02_04195	ENOG4105C8U	phosphate abc transporter
G4Z02_04200	ENOG4105E2Z	phosphate ABC transporter (Permease
G4Z02_04210	ENOG4108UTW	Plays a role in the regulation of phosphate uptake
G4Z02_04215	ENOG4105BZU	Histidine kinase
G4Z02_04225	ENOG4108Z1Y	Participates in both the initiation and recycling phases of transcription. In the presence of the delta subunit, RNAP displays an increased specificity of transcription, a decreased affinity for nucleic acids, and an increased efficiency of RNA synthesis because of enhanced recycling (By similarity)
G4Z02_04230	ENOG4105C8D	Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen (By similarity)
G4Z02_04235	ENOG4105D1U	peptidase U62 modulator of DNA gyrase
G4Z02_04240	ENOG4105D1U	peptidase U62 modulator of DNA gyrase
G4Z02_04260	ENOG4105D7W	serine acetyltransferase
G4Z02_04265	ENOG4105C6T	cysteine synthase
G4Z02_04270	ENOG4105CRK	lysyL-tRNA synthetase
G4Z02_04280	ENOG41082I2	s4 domain protein
G4Z02_04285	ENOG4105C3H	Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins (By similarity)
G4Z02_04290	ENOG4105D3U	Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine (By similarity)
G4Z02_04305	ENOG4105DEU	major facilitator superfamily
G4Z02_04310	ENOG4108Z03	MAF-like protein
G4Z02_04325	ENOG4105C6K	Malic enzyme
G4Z02_04340	ENOG4105VFB	Binds the 23S rRNA (By similarity)
G4Z02_04350	ENOG4105VMP	Transcriptional regulator
G4Z02_04360	ENOG4107QIZ	NADH dehydrogenase
G4Z02_04395	ENOG410902H	NADH dehydrogenase (Ubiquinone), 24 kDa subunit
G4Z02_04400	ENOG4107104	thymidine kinase
G4Z02_04405	ENOG4108Z6B	deaminase
G4Z02_04420	ENOG4108X4Q	Hydrolase
G4Z02_04425	ENOG4105BZU	Histidine kinase
G4Z02_04430	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
G4Z02_04435	ENOG4107RE5	NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34 (By similarity)
G4Z02_04440	ENOG4105D28	Specifically methylates the N7 position of a guanine in 16S rRNA (By similarity)
G4Z02_04455	ENOG4107QJE	Chromosome Partitioning Protein
G4Z02_04460	ENOG4105FA0	parb-like partition protein
G4Z02_04465	ENOG4105D8X	mechanosensitive ion channel
G4Z02_04470	ENOG4105VDK	protein, conserved in bacteria
G4Z02_04560	ENOG4105CP4	Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth (By similarity)
G4Z02_04565	ENOG4105DC1	bifunctional purine biosynthesis protein purh
G4Z02_04570	ENOG4105CM0	Catalyzes the synthesis of GMP from XMP (By similarity)
G4Z02_04575	ENOG4105CV2	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates (By similarity)
G4Z02_04580	ENOG4105DDT	Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP (By similarity)
G4Z02_04610	ENOG4105E5Q	amino acid AbC transporter
G4Z02_04620	ENOG4108HW3	(ABC) transporter
G4Z02_04630	ENOG4105C4X	radical SAM domain protein
G4Z02_04650	ENOG4107T40	Inherit from COG: Glycosyltransferase 36
G4Z02_04655	ENOG4107QK4	glycoside hydrolase, family 3 domain protein
G4Z02_04665	ENOG4105C50	Binding-protein-dependent transport systems, inner membrane component
G4Z02_04680	ENOG4105DRS	transport system, permease
G4Z02_04720	ENOG4105D9R	oxidoreductase
G4Z02_04725	ENOG4105DRI	Involved in the oxidation of myo-inositol (MI) to 2- keto-myo-inositol (2KMI or 2-inosose) (By similarity)
G4Z02_04740	ENOG4105CT4	transporter
G4Z02_04770	ENOG4108V06	Glutathione peroxidase
G4Z02_04785	ENOG4105FQP	Beta-lactamase
G4Z02_04800	ENOG4105D7K	pfkb domain protein
G4Z02_04805	ENOG4105C7Q	Catalyzes the oxidative decarboxylation of 6- phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH (By similarity)
G4Z02_04815	ENOG4105DMW	Dehydrogenase reductase
G4Z02_04820	ENOG4105D2H	Uronic isomerase
G4Z02_04830	ENOG4105DW3	Response regulator receiver modulated metal dependent phosphohydrolase
G4Z02_04935	ENOG4108UVJ	appr-1-p processing domain protein
G4Z02_04940	ENOG4107SQC	5-methylcytosine-specific restriction enzyme subunit McrC
G4Z02_04945	ENOG4105FBQ	ATPase associated with various cellular activities aaa_5
G4Z02_04980	ENOG4108XBJ	The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane (By similarity)
G4Z02_04990	ENOG4105CZC	PTS system ascorbate-specific transporter subunit IIC
G4Z02_04995	ENOG4105KRI	phosphocarrier protein (HPr
G4Z02_05015	ENOG4105DDZ	Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity)
G4Z02_05040	ENOG4105CM0	Catalyzes the synthesis of GMP from XMP (By similarity)
G4Z02_05055	ENOG4105K7Z	Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity)
G4Z02_05070	ENOG4105CUZ	uba thif-type nad fad binding protein
G4Z02_05080	ENOG4105C1J	atp-dependent rna helicase
G4Z02_05135	ENOG4107VXM	glycerophosphoryl diester phosphodiesterase
G4Z02_05145	ENOG4107RFD	Non-specific O-methyltransferase that catalyzes the 2 O- methylation steps in the ubiquinone biosynthetic pathway (By similarity)
G4Z02_05170	ENOG4108KR4	dihydrodipicolinate reductase
G4Z02_05175	ENOG4105EYW	Ion transport protein
G4Z02_05180	ENOG4105Z5Q	
G4Z02_05185	ENOG4107RH1	pyridoxal-5'-phosphate-dependent protein beta subunit
G4Z02_05190	ENOG4105KIJ	D-ornithine aminomutase S component
G4Z02_05195	ENOG4105EQ5	D-Lysine 5,6-aminomutase alpha subunit
G4Z02_05205	ENOG4106M28	alanine racemase domain protein
G4Z02_05210	ENOG4105CJ4	Catalyzes the interconversion of L-alanine and D- alanine. May also act on other amino acids (By similarity)
G4Z02_05220	ENOG4105DBV	ornithine carbamoyltransferase
G4Z02_05250	ENOG4105C0S	IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit (By similarity)
G4Z02_05260	ENOG4108Z10	Involved in the binding of tRNA to the ribosomes (By similarity)
G4Z02_05265	ENOG4105EEE	One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit (By similarity)
G4Z02_05270	ENOG4106U5A	One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity)
G4Z02_05275	ENOG41080UE	One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome (By similarity)
G4Z02_05280	ENOG4105CFD	One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity
G4Z02_05285	ENOG4105K7S	Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA (By similarity)
G4Z02_05290	ENOG4105KAP	The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome (By similarity)
G4Z02_05295	ENOG4105CKE	Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation (By similarity)
G4Z02_05305	ENOG41082SA	50s ribosomal protein l29
G4Z02_05325	ENOG4105CW6	This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits
G4Z02_05335	ENOG4108UJY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit (By similarity)
G4Z02_05340	ENOG4108R5J	This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7 L12 stalk, and near the tRNA binding site of the peptidyltransferase center (By similarity)
G4Z02_05345	ENOG4105K4C	This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance (By similarity)
G4Z02_05350	ENOG4108RA9	Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body (By similarity)
G4Z02_05360	ENOG4108UZ0	Binds to the 23S rRNA (By similarity)
G4Z02_05365	ENOG4105CGG	The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently (By similarity)
G4Z02_05370	ENOG4105CC8	Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism (By similarity)
G4Z02_05375	ENOG4105CA1	Removes the N-terminal methionine from nascent proteins (By similarity)
G4Z02_05380	ENOG4105K9U	however, it seems to stimulate more or less all the activities of the other two initiation factors, IF-2 and IF-3 (By similarity)
G4Z02_05385	ENOG41067V7	50S ribosomal protein L36
G4Z02_05390	ENOG4108Z04	Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits
G4Z02_05395	ENOG4108UHH	Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome (By similarity)
G4Z02_05400	ENOG4105CTF	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
G4Z02_05405	ENOG4108ZT0	50S ribosomal protein l17
G4Z02_05425	ENOG4105CIG	ABC transporter
G4Z02_05440	ENOG4108JJB	ABC transporter
G4Z02_05445	ENOG4108JJB	ABC transporter
G4Z02_05450	ENOG4105EK6	Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates (By similarity)
G4Z02_05455	ENOG4105DI7	Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs (By similarity)
G4Z02_05475	ENOG4105DC7	peptidase M24
G4Z02_05520	ENOG4105FDK	ABC transporter
G4Z02_05525	ENOG4108ZMD	Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis (By similarity)
G4Z02_05530	ENOG4105FA2	dna polymerase iii
G4Z02_05535	ENOG4105MA4	psp1 domain protein
G4Z02_05540	ENOG41060K3	Methyltransferase
G4Z02_05545	ENOG4105CU0	Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA (By similarity)
G4Z02_05560	ENOG4105DDZ	Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity)
G4Z02_05575	ENOG4105C59	p-type ATPase
G4Z02_05590	ENOG4108WZ2	response regulator
G4Z02_05615	ENOG4105C59	p-type ATPase
G4Z02_05630	ENOG4105E3W	Two component transcriptional regulator (Winged helix family
G4Z02_05710	ENOG4105W5Q	DNA repair protein (RadC
G4Z02_05725	ENOG4105D3A	purine nucleoside phosphorylase DeoD-type
G4Z02_05735	ENOG410801F	ribosomal-protein-alanine acetyltransferase
G4Z02_05740	ENOG4108C33	Resolvase
G4Z02_05785	ENOG4105CI3	gtp-binding protein typa
G4Z02_05810	ENOG4105ED2	Beta-lactamase
G4Z02_05845	ENOG4105DW3	Response regulator receiver modulated metal dependent phosphohydrolase
G4Z02_05870	ENOG4105DW3	Response regulator receiver modulated metal dependent phosphohydrolase
G4Z02_05875	ENOG41064RH	membrane protein YliF
G4Z02_05885	ENOG4105CIG	ABC transporter
G4Z02_05915	ENOG4108UM5	This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly (By similarity)
G4Z02_05920	ENOG4108UJD	30S ribosomal protein S9
G4Z02_05935	ENOG4105C9Y	Catalyzes the hydrolysis of N-succinyl-L,L- diaminopimelic acid (SDAP), forming succinate and LL-2,6- diaminoheptanedioate (DAP), an intermediate involved in the bacterial biosynthesis of lysine and meso-diaminopimelic acid, an essential component of bacterial cell walls (By similarity)
G4Z02_05940	ENOG4105DW3	Response regulator receiver modulated metal dependent phosphohydrolase
G4Z02_05945	ENOG4108K0B	C-di-gmp phosphodiesterase
G4Z02_05975	ENOG4105E2R	ROK family
G4Z02_05985	ENOG4105FE9	pseudouridine synthase
G4Z02_05995	ENOG4105CHR	reductase
G4Z02_06000	ENOG4105CH2	amidohydrolase
G4Z02_06005	ENOG4105C20	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity)
G4Z02_06010	ENOG4105C20	Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu) (By similarity)
G4Z02_06020	ENOG4105C8N	cysteinyl-tRNA synthetase
G4Z02_06025	ENOG4105KEB	Involved in correct processing of both the 5' and 3' ends of 23S rRNA precursor. Processes 30S rRNA precursor transcript even in absence of ribonuclease 3 (Rnc)
G4Z02_06050	ENOG4105BZU	Histidine kinase
G4Z02_06055	ENOG4105CK6	Two component transcriptional regulator (Winged helix family
G4Z02_06065	ENOG4105DPZ	Two component transcriptional regulator (Winged helix family
G4Z02_06085	ENOG4105EAY	pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for
G4Z02_06095	ENOG4105DIB	Oligopeptide-binding protein
G4Z02_06100	ENOG4105CJM	Binding-protein-dependent transport systems, inner membrane component
G4Z02_06105	ENOG4105C2T	Binding-protein-dependent transport systems, inner membrane component
G4Z02_06120	ENOG4108JQ7	(ABC) transporter
G4Z02_06140	ENOG4105CEM	UPF0597 protein
G4Z02_06145	ENOG4105C2N	RNA methyltransferase TrmH family group 3
G4Z02_06155	ENOG4107FGU	50S ribosomal protein L33
G4Z02_06165	ENOG4105E5V	Participates in transcription elongation, termination and antitermination (By similarity)
G4Z02_06170	ENOG4108UIK	This protein binds directly to 23S ribosomal RNA (By similarity)
G4Z02_06180	ENOG4108VZM	50s ribosomal protein L10
G4Z02_06185	ENOG41082SK	Seems to be the binding site for several of the factors involved in protein synthesis and appears to be essential for accurate translation (By similarity)
G4Z02_06190	ENOG4107Y49	methyltransferase
G4Z02_06195	ENOG4108IIJ	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
G4Z02_06200	ENOG4105D27	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates (By similarity)
G4Z02_06225	ENOG4108UKE	Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit (By similarity)
G4Z02_06230	ENOG4108UHY	One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA (By similarity)
G4Z02_06240	ENOG4105CGV	This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis (By similarity)
G4Z02_06290	ENOG4105BZU	Histidine kinase
G4Z02_06310	ENOG4105C53	Part of the ABC transporter complex PotABCD involved in spermidine putrescine import. Responsible for energy coupling to the transport system (By similarity)
G4Z02_06320	ENOG4105F8V	Hydrolase, tatD family
G4Z02_06325	ENOG4105C0H	protease
G4Z02_06330	ENOG4105C3G	gtp-binding protein
G4Z02_06335	ENOG4107ZY0	Phenazine biosynthesis-like protein
G4Z02_06340	ENOG4105CEV	competence damage-inducible protein
G4Z02_06360	ENOG4108UUM	single-stranded DNA-binding protein
G4Z02_06365	ENOG4105VH8	Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit (By similarity)
G4Z02_06370	ENOG4105BZR	domain protein
G4Z02_06375	ENOG4105CDU	Replicative dna helicase
G4Z02_06380	ENOG4107QW8	radical SAM domain protein
G4Z02_06390	ENOG4108IJ0	Aspartate ammonia-lyase
G4Z02_06395	ENOG4105C1H	Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA- cmnm(5)s(2)U34 (By similarity)
G4Z02_06405	ENOG4107QI1	Mate efflux family protein
G4Z02_06410	ENOG4105C8K	Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA (By similarity)
G4Z02_06415	ENOG4105EQY	Methylates the class 1 translation termination release factors RF1 PrfA and RF2 PrfB on the glutamine residue of the universally conserved GGQ motif (By similarity)
G4Z02_06420	ENOG4105C73	Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone (By similarity)
G4Z02_06425	ENOG4105CCP	Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC)
G4Z02_06430	ENOG4105VBN	Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY ffh. May be a regulatory protein (By similarity)
G4Z02_06450	ENOG4105ECK	Fatty Acid Desaturase
G4Z02_06455	ENOG4108KP7	hydrolase
G4Z02_06480	ENOG4105C9W	Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity (By similarity)
G4Z02_06485	ENOG4108UH2	Endonuclease that specifically degrades the RNA of RNA- DNA hybrids (By similarity)
G4Z02_06495	ENOG4105BZ1	(ABC) transporter
G4Z02_06500	ENOG4108YZG	isomerase
G4Z02_06505	ENOG4105CZ5	Catalyzes the conversion of uracil and 5-phospho-alpha- D-ribose 1-diphosphate (PRPP) to UMP and diphosphate (By similarity)
G4Z02_06520	ENOG4105EE4	it plays a direct role in the translocation of protons across the membrane (By similarity)
G4Z02_06525	ENOG4105VH4	F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation (By similarity)
G4Z02_06540	ENOG4105CDG	Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit (By similarity)
G4Z02_06545	ENOG4105J80	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex (By similarity)
G4Z02_06550	ENOG4105C4J	Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits (By similarity)
G4Z02_06555	ENOG4105KNM	Produces ATP from ADP in the presence of a proton gradient across the membrane (By similarity)
G4Z02_06560	ENOG4108EKN	Biotin protein ligase C terminal domain
G4Z02_06565	ENOG4105VKD	bioY protein
G4Z02_06575	ENOG4105KM4	Acetyl-CoA carboxylase, biotin carboxyl carrier protein
G4Z02_06580	ENOG4105CER	acetyl-CoA carboxylase biotin carboxylase
G4Z02_06585	ENOG4107QTG	Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl- CoA (By similarity)
G4Z02_06590	ENOG4107QM9	Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA (By similarity)
G4Z02_06595	ENOG4105CCZ	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity)
G4Z02_06600	ENOG4105CJF	Malonyl coA-acyl carrier protein transacylase
G4Z02_06605	ENOG4105CHR	reductase
G4Z02_06610	ENOG4105C0Q	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP (By similarity)
G4Z02_06615	ENOG4108YXN	Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs (By similarity)
G4Z02_06630	ENOG4107Z0P	This enzyme is involved in nucleotide metabolism it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA (By similarity)
G4Z02_06650	ENOG4105CE9	30S ribosomal protein S2
G4Z02_06655	ENOG4105CU7	Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF- Tu.GTP complex up to the GTP hydrolysis stage on the ribosome (By similarity)
G4Z02_06660	ENOG4105C41	Catalyzes the reversible phosphorylation of UMP to UDP (By similarity)
G4Z02_06675	ENOG4105KNE	Phosphatidate cytidylyltransferase
G4Z02_06680	ENOG4105CEA	Catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP) (By similarity)
G4Z02_06685	ENOG4105DZP	Membrane-associated zinc metalloprotease
G4Z02_06690	ENOG4105C90	Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction proline is first activated by ATP to form Pro- AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys- tRNA(Pro) is not edited by ProRS (By similarity)
G4Z02_06750	ENOG4105F5D	NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na( ) ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol (By similarity)
G4Z02_06760	ENOG4105D6A	Electron transport complex
G4Z02_06765	ENOG4105KME	endoribonuclease L-psp
G4Z02_06770	ENOG4105MAX	Superoxide reductase
G4Z02_06835	ENOG4107R0W	ABC transporter
G4Z02_06840	ENOG4105E5Q	amino acid AbC transporter
G4Z02_06850	ENOG4105EK0	Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (By similarity)
G4Z02_06855	ENOG4105DUN	Mediates zinc uptake. May also transport other divalent cations (By similarity)
G4Z02_06935	ENOG4107QW4	alcohol dehydrogenase
G4Z02_06945	ENOG4105D7N	magnesium and cobalt transport protein CorA
G4Z02_06955	ENOG4105XJC	Two component transcriptional regulator (Winged helix family
G4Z02_06965	ENOG4107QIZ	NADH dehydrogenase
G4Z02_06970	ENOG4107QHI	-hydrogenase
G4Z02_06975	ENOG4108UHA	Essential for recycling GMP and indirectly, cGMP (By similarity)
G4Z02_06980	ENOG4105CI2	imidazolone-5-propionate hydrolase
G4Z02_06990	ENOG4105D43	The glycine cleavage system catalyzes the degradation of glycine (By similarity)
G4Z02_07000	ENOG4108ZNS	ferredoxin-type protein NapF
G4Z02_07010	ENOG41080HI	glycine oxidase
G4Z02_07015	ENOG4105C26	Dehydrogenase
G4Z02_07025	ENOG4105CEQ	signal transduction histidine kinase regulating citrate malate metabolism
G4Z02_07030	ENOG4108MRH	transcriptional regulatory protein
G4Z02_07035	ENOG4105CPQ	Dehydrogenase
G4Z02_07040	ENOG4107EEK	Catalyzes the decarboxylative condensation of pimeloyl- acyl-carrier protein and L-alanine to produce 8-amino-7- oxononanoate (AON), acyl-carrier protein , and carbon dioxide (By similarity)
G4Z02_07065	ENOG4107XGZ	Hydrolase
G4Z02_07080	ENOG4105D6J	arsenicaL-resistance protein
G4Z02_07095	ENOG4105CW3	Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway (By similarity)
G4Z02_07100	ENOG4108RBJ	Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions (By similarity)
G4Z02_07110	ENOG4105WBI	UPF0223 protein
G4Z02_07125	ENOG4107QI6	Cysteine desulfurase
G4Z02_07150	ENOG4105K5M	30s ribosomal protein S16
G4Z02_07155	ENOG4105VB6	UPF0109 protein
G4Z02_07160	ENOG4105KEG	ribosomal-protein-alanine acetyltransferase
G4Z02_07165	ENOG4108IUW	ABC transporter
G4Z02_07170	ENOG4108SDH	ABC, transporter
G4Z02_07175	ENOG4107Z8R	An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes (By similarity)
G4Z02_07180	ENOG4105D6X	Specifically methylates guanosine-37 in various tRNAs (By similarity)
G4Z02_07190	ENOG4108YY1	This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site (By similarity)
G4Z02_07195	ENOG4105ETE	Transcriptional regulator (LacI family
G4Z02_07200	ENOG4105DA0	Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction tyrosine is first activated by ATP to form Tyr- AMP and then transferred to the acceptor end of tRNA(Tyr) (By similarity)
G4Z02_07205	ENOG4107YCR	Transcriptional regulator, ARSR family
G4Z02_07210	ENOG4105C59	p-type ATPase
G4Z02_07220	ENOG4105DW3	Response regulator receiver modulated metal dependent phosphohydrolase
G4Z02_07240	ENOG4105CGM	Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis (By similarity)
G4Z02_07250	ENOG4105C2M	dna polymerase I
G4Z02_07270	ENOG4108ZQD	Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (By similarity)
G4Z02_07290	ENOG4105C22	threonyL-tRNA synthetase
G4Z02_07300	ENOG4108UHA	Essential for recycling GMP and indirectly, cGMP (By similarity)
G4Z02_07310	ENOG4105DE5	Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity (By similarity)
G4Z02_07335	ENOG4105C6A	phenylalanyl-tRNA synthetase (beta subunit)
G4Z02_07350	ENOG4105C1I	TRANSCRIPTIONAl REGULATOR GntR family
G4Z02_07355	ENOG4108UHX	Involved in the hydrolysis of glutamine to glutamate and ammonia. Channels an ammonia molecule to PdxS (By similarity)
G4Z02_07365	ENOG4108RAV	Conserved protein
G4Z02_07375	ENOG4105C55	Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs
G4Z02_07435	ENOG410630P	Transcriptional regulator
G4Z02_07440	ENOG4105E06	May play a role in 30S ribosomal subunit biogenesis. Unusual circulary permuted GTPase that catalyzes rapid hydrolysis of GTP with a slow catalytic turnover (By similarity)
G4Z02_07455	ENOG4105VB9	50S ribosomal protein l28
G4Z02_07460	ENOG4105DDZ	Methyltransferase required for the conversion of demethylmenaquinone (DMKH2) to menaquinone (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) (By similarity)
G4Z02_07465	ENOG4105DP4	dak2 domain fusion protein ylov
G4Z02_07470	ENOG4105CB5	ATP-dependent DNA helicase recG
G4Z02_07475	ENOG4105C6B	Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl- acyl-carrier-protein (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA (By similarity)
G4Z02_07480	ENOG4108ZBM	Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity)
G4Z02_07490	ENOG4105CSM	endonuclease III
G4Z02_07500	ENOG4105D1F	ATP-binding protein
G4Z02_07505	ENOG4105CDE	UPF0348 protein
G4Z02_07515	ENOG41067VY	50S ribosomal protein L32
G4Z02_07550	ENOG4105CJW	magnesium transporter
G4Z02_07555	ENOG41082BV	acetyltransferase
G4Z02_07565	ENOG4105KRI	phosphocarrier protein (HPr
G4Z02_07585	ENOG4105C31	Tryptophanyl-tRNA synthetase
G4Z02_07595	ENOG41090SU	Interferes with activator-stimulated transcription by interaction with the RNA polymerase alpha-CTD. May function to globally reduce transcription of genes involved in growth- and development-promoting processes and to increase transcription of genes involved in thiol homeostasis, during periods of extreme stress (By similarity)
G4Z02_07605	ENOG4105C7H	Helicase, RecD TraA family
G4Z02_07610	ENOG4105CIM	Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction alanine is first activated by ATP to form Ala- AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain (By similarity)
G4Z02_07615	ENOG4108Z08	Could be a nuclease that resolves Holliday junction intermediates in genetic recombination (By similarity)
G4Z02_07630	ENOG4105XYU	peptidase (U32 family)
G4Z02_07635	ENOG4105CFP	Peptidase U32
G4Z02_07640	ENOG4105DBI	uridine monophosphokinase
G4Z02_07645	ENOG4107YHV	Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides (By similarity)
G4Z02_07650	ENOG4105DUF	Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S- adenosylhomocysteine (SAH AdoHcy) to adenine and the corresponding thioribose, 5'-methylthioribose and S-ribosylhomocysteine, respectively (By similarity)
G4Z02_07670	ENOG4105CQW	ribosome biogenesis GTPase YqeH
G4Z02_07675	ENOG4108WF2	Metal Dependent Phosphohydrolase
G4Z02_07685	ENOG4105DXX	methyltransferase
G4Z02_07695	ENOG4105KQC	Competence protein
G4Z02_07700	ENOG4105EGY	DNA internalization-related competence protein ComEC Rec2
G4Z02_07705	ENOG4105TQK	DNA polymerase iii, delta' subunit
G4Z02_07710	ENOG410855X	Binds directly to 16S ribosomal RNA (By similarity)
G4Z02_07725	ENOG4105QNR	S1 RNA binding domain protein
G4Z02_07730	ENOG4105CDY	transcriptional regulatory protein
G4Z02_07740	ENOG4105BZQ	cdp-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase
G4Z02_07745	ENOG4105C68	Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage (By similarity)
G4Z02_07750	ENOG4105CQP	nitrilase cyanide hydratase and apolipoprotein n-acyltransferase
G4Z02_07760	ENOG4105E4Y	Endoribonuclease that initiates mRNA decay (By similarity)
G4Z02_07765	ENOG4108XXK	NUDIX hydrolase
G4Z02_07770	ENOG4105D48	metallophosphoesterase
G4Z02_07775	ENOG4105CIW	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity)
G4Z02_07790	ENOG4105D86	that it carries out the mismatch recognition step. This protein has a weak ATPase activity (By similarity)
G4Z02_07800	ENOG4105D7V	transposase
G4Z02_07815	ENOG4105DC6	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a molecular matchmaker , a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex (By similarity)
G4Z02_07820	ENOG4105DKX	Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A) (By similarity)
G4Z02_07835	ENOG4105CCY	NADH flavin oxidoreductase, NADH oxidase
G4Z02_07855	ENOG4105CIG	ABC transporter
G4Z02_07865	ENOG4105CFB	Gamma-glutamyltranspeptidase (EC 2.3.2.2)
G4Z02_07875	ENOG4105DRH	Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase (By similarity)
G4Z02_07880	ENOG4108JU6	CBS domain protein
G4Z02_07885	ENOG4105FE9	pseudouridine synthase
G4Z02_07890	ENOG4105CAT	Cytidine monophosphate kinase
G4Z02_07895	ENOG4105CAV	thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence (By similarity)
G4Z02_07905	ENOG4105CSF	NADPH-dependent glycerol-3-phosphate dehydrogenase
G4Z02_07910	ENOG4105K70	DNA-binding protein
G4Z02_07930	ENOG4107ZYR	domain protein
G4Z02_07940	ENOG4108RAC	Rubrerythrin
G4Z02_07960	ENOG4105CG3	alpha amylase, catalytic region
G4Z02_07975	ENOG4105F38	ABC transporter, permease
G4Z02_07980	ENOG4105D38	putrescine abc transporter
G4Z02_07990	ENOG4105M7K	Involved in the transcription termination process (By similarity)
G4Z02_07995	ENOG4105DVS	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity)
G4Z02_08000	ENOG41067QG	Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides (By similarity)
G4Z02_08005	ENOG4105C2V	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) (By similarity)
G4Z02_08010	ENOG4105C4F	May be involved in recombinational repair of damaged DNA (By similarity)
G4Z02_08020	ENOG4105CQ3	Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity)
G4Z02_08030	ENOG4105C48	Converts 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP) (By similarity)
G4Z02_08035	ENOG4105C1J	atp-dependent rna helicase
G4Z02_08055	ENOG4105EH2	Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr) (By similarity)
G4Z02_08060	ENOG4108UIQ	Methylates the ribose at the nucleotide 34 wobble position in the two leucyl isoacceptors tRNA(Leu)(CmAA) and tRNA(Leu)(cmnm5UmAA). Catalyzes the methyl transfer from S- adenosyl-L-methionine to the 2'-OH of the wobble nucleotide (By similarity)
G4Z02_08090	ENOG4105DER	m42 family
G4Z02_08095	ENOG4108Z1W	Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD) (By similarity)
G4Z02_08100	ENOG4108DWA	Nad synthetase
G4Z02_08105	ENOG4105CCJ	Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34 (By similarity)
G4Z02_08110	ENOG4107ZE5	PPIases accelerate the folding of proteins
G4Z02_08140	ENOG4105C46	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source (By similarity)
G4Z02_08145	ENOG4107QJF	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate (By similarity)
G4Z02_08150	ENOG4105CAJ	Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP- GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5- monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain (By similarity)
G4Z02_08155	ENOG4108UUX	IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins (By similarity)
G4Z02_08165	ENOG4108YZX	Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit (By similarity)
G4Z02_08185	ENOG41085GJ	domain protein
G4Z02_08190	ENOG4105K56	Transcriptional regulator
G4Z02_08195	ENOG4105CN9	Peptidase m42 family protein
G4Z02_08200	ENOG4106H78	methyltransferase
G4Z02_08205	ENOG4108ZEF	Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate (By similarity)
G4Z02_08235	ENOG4105E0M	Sulfatase
G4Z02_08250	ENOG4105C13	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
G4Z02_08275	ENOG4107R3N	Filamentation induced by cAMP protein fic
G4Z02_08325	ENOG4105ED2	Beta-lactamase
G4Z02_08360	ENOG4105E09	nadh pyrophosphatase
G4Z02_08370	ENOG4105DEA	Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation
G4Z02_08375	ENOG4105CZC	PTS system ascorbate-specific transporter subunit IIC
G4Z02_08380	ENOG4108KP7	hydrolase
G4Z02_08385	ENOG4108X7Y	Mannitol-specific cryptic phosphotransferase enzyme iia
G4Z02_08415	ENOG4105DKT	Transcriptional regulator
G4Z02_08420	ENOG4105BZ3	General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr) (By similarity)
G4Z02_08425	ENOG4105KRI	phosphocarrier protein (HPr
G4Z02_08430	ENOG4105C6P	ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner (By similarity)
G4Z02_08475	ENOG4105FCD	Major Facilitator
G4Z02_08485	ENOG4105WHM	Necessary for normal cell division and for the maintenance of normal septation (By similarity)
G4Z02_08495	ENOG4105CQ4	Transcriptional regulator
G4Z02_08505	ENOG4105CAC	Catalyzes the conversion of L-arabinose to L-ribulose (By similarity)
G4Z02_08510	ENOG4107R0P	L-ribulose-5-phosphate 4-epimerase
G4Z02_08515	ENOG4105DFW	ABC transporter
G4Z02_08525	ENOG4108HWW	ABC transporter
G4Z02_08535	ENOG4105DPM	folylpolyglutamate synthase Dihydrofolate synthase
G4Z02_08540	ENOG4105W5Q	DNA repair protein (RadC
G4Z02_08550	ENOG4105KK9	This protein binds to 23S rRNA in the presence of protein L20 (By similarity)
G4Z02_08570	ENOG4105CAT	Cytidine monophosphate kinase
G4Z02_08575	ENOG4105C9R	An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate (By similarity). It may play a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control
G4Z02_08580	ENOG410852I	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB (By similarity)
G4Z02_08610	ENOG4105HDK	L-asparaginase
G4Z02_08625	ENOG4105D1H	recombination factor protein RarA
G4Z02_08635	ENOG4105VYW	UPF0251 protein
G4Z02_08645	ENOG4105UIB	(ABC) transporter
G4Z02_08650	ENOG4108JQ9	ABC transporter
G4Z02_08655	ENOG41076CZ	activating enzyme
G4Z02_08660	ENOG4105G0K	glycine radical enzyme YjjI family
G4Z02_08665	ENOG4107TFB	basic membrane
G4Z02_08685	ENOG4105CXW	Synthesizes alpha-1,4-glucan chains using ADP-glucose (By similarity)
G4Z02_08715	ENOG4108YYV	Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity)
G4Z02_08720	ENOG4105C0V	Provides the sole de novo source of dTMP for DNA biosynthesis (By similarity)
G4Z02_08730	ENOG4105Z8H	single-stranded DNA-binding protein
G4Z02_08745	ENOG4108HMR	Key enzyme in the regulation of glycerol uptake and metabolism (By similarity)
G4Z02_08765	ENOG4107TH2	purine nucleoside phosphorylase
G4Z02_08770	ENOG4105FCI	Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy- D-ribose 5-phosphate (By similarity)
G4Z02_08785	ENOG4105C07	amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile) (By similarity)
G4Z02_08800	ENOG4105VR5	Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA (By similarity)
G4Z02_08805	ENOG4105DFA	alanine racemase domain protein
G4Z02_08815	ENOG4105CDK	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity (By similarity)
G4Z02_08820	ENOG4105C6U	Exchanges the guanine residue with 7-aminomethyl-7- deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). After this exchange, a cyclopentendiol moiety is attached to the 7-aminomethyl group of 7-deazaguanine, resulting in the hypermodified nucleoside queuosine (Q) (7-(((4,5-cis- dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine) (By similarity)
G4Z02_08830	ENOG4105UEI	Transcriptional Regulator AraC Family
G4Z02_08840	ENOG4105C0F	tryptophanase EC 4.1.99.1
G4Z02_08850	ENOG4105E2N	Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA) (By similarity)
G4Z02_08855	ENOG4105CKJ	The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing (By similarity)
G4Z02_08875	ENOG4105C13	Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids (By similarity)
G4Z02_08880	ENOG4105CSA	Coproporphyrinogen iii oxidase
G4Z02_08885	ENOG4105C4S	Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back- translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner (By similarity)
G4Z02_08890	ENOG4105D1Q	UPF0246 protein
G4Z02_08910	ENOG4107QUF	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3'- to 5'-direction (By similarity)
G4Z02_08920	ENOG4105C02	permease
G4Z02_08925	ENOG4105K77	Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome (By similarity)
G4Z02_08930	ENOG4105DTN	riboflavin biosynthesis protein ribF
G4Z02_08935	ENOG4105D0T	Responsible for synthesis of pseudouridine from uracil- 55 in the psi GC loop of transfer RNAs (By similarity)
G4Z02_08940	ENOG4105K63	Thioredoxin
G4Z02_08945	ENOG4105C98	muts2 protein
G4Z02_08965	ENOG4107QW4	alcohol dehydrogenase
G4Z02_08980	ENOG4105CQ3	Poorly processive error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by polIV. Exhibits no 3-5 exonuclease (proofreading) activity. May be involved in translesional synthesis in conjunction with the beta clamp from polIII (By similarity)
G4Z02_08990	ENOG4105C34	Pseudouridine synthase
G4Z02_08995	ENOG4105M02	This protein specifically catalyzes the removal of signal peptides from prolipoproteins (By similarity)
G4Z02_09005	ENOG41063PX	domain protein
G4Z02_09010	ENOG4107YWA	deoxycytidylate deaminase
G4Z02_09020	ENOG4105DD7	kinase (PfkB family
G4Z02_09030	ENOG4105CUZ	uba thif-type nad fad binding protein
G4Z02_09040	ENOG4105C02	permease
G4Z02_09050	ENOG4105CUT	histidyl-tRNA synthetase
G4Z02_09065	ENOG4108YYA	Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine (By similarity)
G4Z02_09070	ENOG4105CWR	In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance (By similarity)
G4Z02_09075	ENOG4109003	Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis (By similarity)
G4Z02_09080	ENOG4105C2R	Single-stranded-DNA-specific exonuclease (RecJ)
G4Z02_09085	ENOG4105C75	arginyL-tRNA synthetase
G4Z02_09105	ENOG4105C7D	DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings (By similarity)
G4Z02_09110	ENOG4105K7Z	Catalyzes the transfer of an acyl group from acyl- phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP (By similarity)
G4Z02_09120	ENOG4105VXM	UPF0154 protein
G4Z02_09130	ENOG4105EGD	dinuclear metal center protein, YbgI family
G4Z02_09140	ENOG4105DG1	Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released (By similarity)
G4Z02_09145	ENOG4105C9G	DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments on both template strands at replication forks during chromosomal DNA synthesis (By similarity)
G4Z02_09150	ENOG4105D9H	Catalyzes the attachment of glycine to tRNA(Gly) (By similarity)
G4Z02_09155	ENOG4108SAY	Involved in DNA repair and RecF pathway recombination (By similarity)
G4Z02_09160	ENOG4105CWT	An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism (By similarity)
G4Z02_09165	ENOG4105KG3	cytidine deaminase
G4Z02_09170	ENOG41080V7	Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA (By similarity)
G4Z02_09175	ENOG4105C9A	Phoh family
G4Z02_09180	ENOG4105VCC	30S ribosomal protein S21
G4Z02_09190	ENOG4105CIW	Catalyzes the methylthiolation of N6- (dimethylallyl)adenosine (i(6)A), leading to the formation of 2- methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine (By similarity)
G4Z02_09195	ENOG4107TVK	Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit (By similarity)
G4Z02_09200	ENOG4105BZ5	ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins (By similarity)
G4Z02_09205	ENOG4105CFG	Acts as a chaperone (By similarity)
G4Z02_09210	ENOG4105K90	Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ
G4Z02_09215	ENOG4105CI8	Negative regulator of class I heat shock genes (grpE- dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons (By similarity)
G4Z02_09220	ENOG4105C5X	domain protein
G4Z02_09230	ENOG41087P5	50S ribosomal protein L33
G4Z02_09235	ENOG4105C4E	Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (By similarity)
G4Z02_09255	ENOG4106A3R	peptidase
G4Z02_09265	ENOG4105D7Q	type ii secretion system
G4Z02_09270	ENOG4107QHF	type ii secretion system protein e
G4Z02_09295	ENOG4107QN2	dihydrolipoyl dehydrogenase
G4Z02_09300	ENOG4107RGW	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
G4Z02_09305	ENOG4107QK8	The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor
G4Z02_09310	ENOG4105KE9	The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein (By similarity)
G4Z02_09315	ENOG4105D43	The glycine cleavage system catalyzes the degradation of glycine (By similarity)
G4Z02_09320	ENOG4105C0G	Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives (By similarity)
G4Z02_09325	ENOG4108ZUF	This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control (By similarity)
G4Z02_09335	ENOG4105C6H	Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction (By similarity)
G4Z02_09340	ENOG4107TXC	Transcriptional regulator
G4Z02_09350	ENOG4105C8F	Beta-lactamase domain protein
G4Z02_09355	ENOG4105KGF	protein, YerC YecD
G4Z02_09370	ENOG4105BZ8	glutamate synthase
G4Z02_09375	ENOG4105CQV	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
G4Z02_09385	ENOG4105ES3	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity)
G4Z02_09390	ENOG4105CMZ	NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone (By similarity)
G4Z02_09395	ENOG4108JPZ	Monovalent cation H antiporter subunit D
G4Z02_09400	ENOG4108JPZ	Monovalent cation H antiporter subunit D
G4Z02_09410	ENOG4105GND	monovalent cation H antiporter subunit B
G4Z02_09420	ENOG4105KJM	monovalent cation h antiporter subunit g
G4Z02_09430	ENOG4105SC1	monovalent cation H antiporter subunit E
G4Z02_09440	ENOG4105BZ1	(ABC) transporter
G4Z02_09445	ENOG4105BZ1	(ABC) transporter
G4Z02_09450	ENOG4105C5H	ABC transporter
G4Z02_09460	ENOG4105BZ1	(ABC) transporter
G4Z02_09465	ENOG4105BZ1	(ABC) transporter
G4Z02_09475	ENOG4105CE9	30S ribosomal protein S2
G4Z02_09480	ENOG4105C80	Catalyzes the reversible oxidation of malate to oxaloacetate (By similarity)
G4Z02_09500	ENOG4105BZ1	(ABC) transporter
G4Z02_09505	ENOG4105BZ1	(ABC) transporter
G4Z02_09530	ENOG41074FZ	May increase the rate of spontaneous hydrolysis of aminoacrylate to malonic semialdehyde. Required to remove a toxic intermediate produce in the pyrimidine nitrogen degradation (By similarity)
G4Z02_09535	ENOG4107WD4	Releases the N-terminal proline from various substrates (By similarity)
G4Z02_09540	ENOG4105CYC	Transferase
G4Z02_09550	ENOG4108IV0	ABC, transporter
G4Z02_09555	ENOG4105C0Z	ABC transporter
G4Z02_09570	ENOG4105CCZ	Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched- chain and or straight-chain of fatty acids (By similarity)
G4Z02_09575	ENOG4105CHR	reductase